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Sample records for afetivo bipolar carga

  1. Transtorno afetivo bipolar: carga da doença e custos relacionados Bipolar disorder: burden of disease and related costs

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    Anna Maria Niccolai Costa

    2008-01-01

    Full Text Available CONTEXTO: O transtorno afetivo bipolar (TAB é uma doença recorrente, crônica e grave. Comorbidades psiquiátricas e físicas, aumento do risco de suicídio, maior utilização de serviços de saúde e prejuízo na esfera social/profissional aumentam significativamente a carga e custos relacionados à doença. OBJETIVOS: Revisar aspectos clínicos, de carga da doença e conseqüentes desfechos financeiros do TAB. MÉTODOS: Pesquisa de base de dados MEDLINE/PubMed utilizando os termos bipolar disorder, epidemiology, burden of disease, comorbidity, cost of illness, outcomes e financial consequences, publicados entre 1980 e 2006. RESULTADOS: O TAB apresenta alta comorbidade com outros transtornos, o que agrava seu prognóstico e eleva os custos com os serviços de saúde. Os indivíduos com TAB apresentam mais fatores de risco cardiovascular e, conseqüentemente, maior risco de morte por evento cardíaco. O atraso e o erro diagnóstico no TAB elevam consideravelmente a carga e os custos da doença. CONCLUSÕES: As comorbidades, o risco de suicídio, o prejuízo social/profissional e a baixa adesão ao tratamento contribuem para a alta carga e os custos associados à doença. A pesquisa de comorbidades pode ajudar os médicos a ajustarem suas estratégias de tratamento, considerando cuidadosamente todos os fatores de risco e custos associados, fatores estes que devem ser levados em conta também pelos profissionais que trabalham com gestão de saúde, tanto no setor privado quanto público.BACKGROUND: Bipolar disorder (BD is a recurrent, chronic and severe disease. Mental and physical comorbidities, risk of suicide, health services use and impairment of social and professional domains significantly worsen the burden and increase the costs of illness. OBJECTIVES: Review clinical aspects, burden of disease, and consequent financial outcomes of BD. METHODS: MEDLINE/PubMed database search using the terms bipolar disorder, epidemiology, burden of

  2. Transtorno afetivo bipolar: um enfoque transcultural

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    Sanches,Marsal; Jorge,Miguel Roberto

    2004-01-01

    Considerando-se que existem diferenças importantes na maneira como as emoções são vivenciadas e expressas em diferentes culturas, a apresentação e o manejo do transtorno afetivo bipolar sofrem influência de fatores culturais. O presente artigo realiza uma breve revisão da evidência referente aos aspectos transculturais do transtorno bipolar.

  3. Relato de caso: transtorno afetivo bipolar

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    Carlos Von Krakauer Hübner; Edson Vinicius Milanello; Maria Fernanda Moro Barbieri; Marcelo Ricardo de Oliveira Barcelos; Lucas Augusto Ayres Ribas

    2016-01-01

    Introdução: O transtorno afetivo bipolar (TAB) é uma doença crônica e grave, marcada pela variância de episódios depressivos com episódios de mania ou hipomania, podendo haver sintomas psicóticos. É classificado em dois tipos, I e II. Sua etiologia é desconhecida, mas supõe-se que envolva influências genéticas e ambientais, variando a cada indivíduo afetado. As apresentações clínicas do TAB podem variar de episódios leves de depressão ou hipomania até episódios depressivos graves ou mania aco...

  4. Relato de caso: transtorno afetivo bipolar

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    Carlos Von Krakauer Hübner

    2016-10-01

    Full Text Available Introdução: O transtorno afetivo bipolar (TAB é uma doença crônica e grave, marcada pela variância de episódios depressivos com episódios de mania ou hipomania, podendo haver sintomas psicóticos. É classificado em dois tipos, I e II. Sua etiologia é desconhecida, mas supõe-se que envolva influências genéticas e ambientais, variando a cada indivíduo afetado. As apresentações clínicas do TAB podem variar de episódios leves de depressão ou hipomania até episódios depressivos graves ou mania acompanhados ou não de sintomas psicóticos. Objetivos: Relatar o caso de um paciente internado na enfermaria da psiquiatria do Conjunto Hospitalar de Sorocaba que foi diagnosticado com TAB. Metodologia: As informações foram obtidas por meio de revisão do prontuário, entrevista com o paciente e revisão da literatura. Relato de Caso: Homem de 20 anos encaminhado do serviço hospitalar de Itapetininga após alteração de comportamento, heteroagressividade e alucinações auditivas. Conclusões: Transtorno depressivo maior, de ansiedade generalizada, de estresse pós-traumático e esquizofrenia são diagnósticos diferenciais. O episódio maníaco provoca prejuízo no funcionamento social, profissional e até necessidade de hospitalização. O risco de suicídio em pessoas com TAB é estimado em pelo menos 15 vezes o da população em geral. A taxa de não adesão ao tratamento no TAB é de 47%. A conduta terapêutica medicamentosa mais eficaz para a mania é a associação do carbonato de lítio com risperidona, já para a depressão bipolar o carbonato de lítio é a primeira escolha.

  5. Psicoterapia em grupo de pacientes com transtorno afetivo bipolar

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    Gomes,Bernardo Carramão; Lafer,Beny

    2007-01-01

    CONTEXTO: Vem crescendo nos últimos anos o número de estudos com abordagens psicoterápicas no tratamento de pacientes com transtorno afetivo bipolar. Contudo, pouco ainda se sabe sobre o efeito que tem estas abordagens nestes pacientes. OBJETIVO: Avaliar a efetividade da terapia de grupo no tratamento do transtorno afetivo bipolar. MÉTODO: Levantamento bibliográfico no Medline, Lilacs, PubMed e ISI de artigos publicados em língua inglesa no período de 1975 a 2005 e busca manual com base na bi...

  6. Transtorno afetivo bipolar: um enfoque transcultural Transcultural aspects of bipolar disorder

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    Marsal Sanches

    2004-10-01

    Full Text Available Considerando-se que existem diferenças importantes na maneira como as emoções são vivenciadas e expressas em diferentes culturas, a apresentação e o manejo do transtorno afetivo bipolar sofrem influência de fatores culturais. O presente artigo realiza uma breve revisão da evidência referente aos aspectos transculturais do transtorno bipolar.Cultural variations in the expression of emotions have been described. Consequently, there are cross-cultural influences on the diagnosis and management of bipolar disorder. This article provides a review of the evidence regarding the main aspects of transcultural psychiatry and bipolar disorder.

  7. Psicoterapia em grupo de pacientes com transtorno afetivo bipolar Group psychotherapy for bipolar disorder patients

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    Bernardo Carramão Gomes

    2007-01-01

    Full Text Available CONTEXTO: Vem crescendo nos últimos anos o número de estudos com abordagens psicoterápicas no tratamento de pacientes com transtorno afetivo bipolar. Contudo, pouco ainda se sabe sobre o efeito que tem estas abordagens nestes pacientes. OBJETIVO: Avaliar a efetividade da terapia de grupo no tratamento do transtorno afetivo bipolar. MÉTODO: Levantamento bibliográfico no Medline, Lilacs, PubMed e ISI de artigos publicados em língua inglesa no período de 1975 a 2005 e busca manual com base na bibliografia dos artigos selecionados. Foram incluídos apenas os estudos que utilizaram grupo controle, randomizados, com casuística superior a 20 pacientes. RESULTADOS: Foram encontrados somente cinco trabalhos, três deles publicados nos últimos cinco anos. Três utilizaram modelos de psicoeducação, encontrando aumento na adesão ao tratamento farmacológico. Um destes verificou redução no número de hospitalizações e recaídas. Dois estudos combinaram psicoeducação e abordagens psicoterápicas variadas. Destes, um mostrou aumento no período de remissão e redução de sintomas para episódios maníacos. CONCLUSÕES: O interesse por intervenções psicoterápicas baseadas em evidência, no tratamento do TAB, vem aumentando nos últimos anos. Este fato contrasta com o baixo número de estudos dedicados à modalidade de atendimento em grupo, que poderia ser muito útil em instituições onde grande número de pacientes é atendido. A complexidade clínica dessa doença, a presença de diversas comorbidades e os diferentes graus de adesão à farmacoterapia demandam a criação de opções terapêuticas variadas que atendam às necessidades de cada indivíduo. Os estudos indicam que a terapia de grupo pode ser uma opção eficaz de tratamento que merece ser mais bem investigado para permitir sua aplicação na prática clínica.BACKGROUND: In the last years there has been a growing number of studies using psychotherapy approaches in the

  8. Transtorno afetivo bipolar: perfil farmacoterapêutico e adesão ao medicamento

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    Miasso,Adriana Inocenti; Carmo,Bruna Paiva do; Tirapelli,Carlos Renato

    2012-01-01

    Este estudo teve como objetivos verificar a adesão de portadores de transtorno afetivo bipolar (TAB) à terapêutica medicamentosa e identificar possíveis causas de adesão e não adesão ao medicamento de acordo com o perfil farmacoterapêutico. Trata-se de estudo transversal, descritivo, realizado em Núcleo de Saúde Mental de um município do interior paulista. Participaram do estudo 101 pacientes com TAB. Para coleta dos dados, utilizou-se a entrevista estruturada e o teste de Morisky-Green e, pa...

  9. Transtorno afetivo bipolar na infância e na adolescência

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    Fu-I,Lee

    2004-01-01

    Os conhecimentos sobre transtorno afetivo bipolar com início na infância e na adolescência têm avançado muito nos últimos 15 anos. Atualmente, os esforços estão dirigidos para investigar o quadro clínico, para o desenvolvimento de instrumentos que auxiliam diagnóstico precoce e investigações de melhores formas de tratamentos de crianças e adolescentes portadores do transtorno. O presente texto tem objetivo de apresentar as principais características clínicas do transtorno em crianças e adoles...

  10. Transtorno afetivo bipolar: perfil farmacoterapêutico e adesão ao medicamento

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    Adriana Inocenti Miasso

    2012-06-01

    Full Text Available Este estudo teve como objetivos verificar a adesão de portadores de transtorno afetivo bipolar (TAB à terapêutica medicamentosa e identificar possíveis causas de adesão e não adesão ao medicamento de acordo com o perfil farmacoterapêutico. Trata-se de estudo transversal, descritivo, realizado em Núcleo de Saúde Mental de um município do interior paulista. Participaram do estudo 101 pacientes com TAB. Para coleta dos dados, utilizou-se a entrevista estruturada e o teste de Morisky-Green e, para a análise dos mesmos, o programa Statistical Package for the Social Science. Os resultados mostraram que a maioria (63% dos sujeitos investigados não adere ao medicamento. Apesar de não ter ocorrido diferenças significativas entre o grupo de aderentes e não aderentes, para as variáveis investigadas, foi possível verificar a utilização de polifarmacoterapia e regimes terapêuticos complexos no tratamento do TAB. Permanece como desafio a implementação de estratégias que possam melhorar, na prática, a adesão de pacientes ao tratamento medicamentoso.

  11. Transtorno afetivo bipolar na infância e na adolescência Bipolar disorder in childhood and adolescence

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    Lee Fu-I

    2004-10-01

    Full Text Available Os conhecimentos sobre transtorno afetivo bipolar com início na infância e na adolescência têm avançado muito nos últimos 15 anos. Atualmente, os esforços estão dirigidos para investigar o quadro clínico, para o desenvolvimento de instrumentos que auxiliam diagnóstico precoce e investigações de melhores formas de tratamentos de crianças e adolescentes portadores do transtorno. O presente texto tem objetivo de apresentar as principais características clínicas do transtorno em crianças e adolescentes, assim como as denominações, as descrições de tipos clínicos e do padrão de ciclagem mais comum da doença em jovens. Discussões sobre comorbidades, diagnóstico diferencial e avanço em tratamento farmacológico também serão apresentados.Many advances in the knowledge of childhood- and adolescent-onset bipolar disorder have been seen over the last 15 years. Current efforts focus on investigating clinical features, developing more instruments for early diagnosis and improving treatment research. The present study aims to present the main clinical characteristic of the disorder in children and adolescents, as well as the nomenclature, description of clinical phenotypes and the most common cycling pattern in youths. A discussion of comorbidity, differential diagnosis and advances in psychopharmacological treatment will also be presented.

  12. Estratégias adotadas por pessoas com Transtorno Afetivo Bipolar e a necessidade de terapêutica medicamentosa

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    Miasso,Adriana Inocenti; Cassiani,Silvia Helena De Bortoli; Pedrão,Luiz Jorge

    2007-01-01

    Este estudo identificou as estratégias adotadas pela pessoa com Transtorno Afetivo Bipolar (TAB) diante da necessidade de uso contínuo de medicamentos. Foi utilizada a abordagem qualitativa, tendo como referencial metodológico a Teoria Fundamentada nos Dados, à luz do Interacionismo Simbólico. Participaram do estudo 14 pessoas com TAB que estavam em acompanhamento em uma Unidade Ambulatorial de Transtornos do Humor de um hospital universitário e 14 familiares indicados pelas mesmas. A entrevi...

  13. Cognição, afeto e relacionamento interpessoal de mulheres com transtorno afetivo bipolar Cognition, affection and interpersonal relationship of women with bipolar disorder

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    Carla Luciano Codani Hisatugo

    2009-01-01

    Full Text Available O transtorno afetivo bipolar causa incapacitação e isolamento social, podendo levar ao suicídio. Tratou-se de estudo clínico de casos múltipos com uso de: Inventário de Depressão (BDI e Suicídio (BSI de Beck, Escala de Depressão de Hamilton (HAM-D e Rorschach, Sistema Compreensivo. O objetivo foi analisar os aspectos afetivos, cognitivos e interpessoais das pacientes. Quatro pacientes foram estudadas. Foram atendidas em ambulatório público e préviamente diagnosticadas com depressão bipolar, segundo Entrevista Psiquiátrica (SCID-I/CV-DSM-IV. Resultados indicaram sentimentos depreciativos na autoimagem, conteúdos eufóricos e falta de insight sobre a auto-tolerância ao estresse. Aspectos emocionais e cognitivos influenciaram no contexto interpessoal, acentuando o sofrimento. Outros dados qualitativos clínicos foram observados e comentados.The bipolar affective disorder induces incapacitation and social isolation, and might lead to suicide. It was a clinical study of multiple cases using the following instruments: Beck Depression Inventory (BDI, Beck Suicide Inventory (BSI, Hamilton Scale of Depression (HAM-D and the Rorschach, by Exner's Comprehensive System (CS. The objective was to analyze the affective, cognitive and interpersonal aspects of the patients. Four female out-patients who were previously diagnosed as bipolar depressive, by the Psychiatry Interview according to Diagnostic and Statistical Manual of Mental Disorders (SCIDI/CV-DSM-IV criteria were studied. Results had indicated undervalued feelings about themselves, euphoric contents and lack of insight about the self-tolerance related to stress controls. Emotional and cognitive aspects have influenced the interpersonal context leading to increased suffering. Other qualitative and clinic data have been observed and commented.

  14. Genes relacionados ao metabolismo dos fosfolípides como fatores de risco para o transtorno afetivo bipolar

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    Meira-Lima Ivanor V

    2003-01-01

    Full Text Available Os estudos de epidemiologia genética fornecem consistente evidência de que o componente genético tem um papel preponderante no risco para o Transtorno Afetivo Bipolar (TAB, embora genes de vulnerabilidade ainda não tenham sido identificados de forma inequívoca. Nesta atualização os autores apresentam dados demonstrando que os fosfolípides exercem um relevante papel nos processos de sinalização intracelular e que estudos da neuroquímica dos estabilizadores do humor convergem em apontar para uma ação destas drogas nas vias de transdução de sinais reguladas pelas fosfolipases. Concluem que investigações de variantes nos genes que codificam enzimas do metabolismo dos fosfolípides como potenciais genes de susceptibilidade podem ampliar o conhecimento acerca dos fatores de risco e dos mecanismos fisiopatológicos envolvidos no surgimento destes transtornos do humor.

  15. Terapêutica medicamentosa: conhecimento e dificuldades de familiares de pessoas idosas com transtorno afetivo bipolar

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    Monteschi,Maristela; Vedana,Kelly Graziani Giacchero; Miasso,Adriana Inocenti

    2010-01-01

    Este estudio cualitativo y cuantitativo tuvo como objetivo determinar el grado de conocimiento y las dificultades de los familiares de ancianos con Trastorno Afectivo Bipolar relacionados al tratamiento farmacológico prescrito al paciente. Participaron del estudio 17 familiares de ancianos con Trastorno Afectivo Bipolar que reciben atención en un Servicio de Salud Mental. Para la recolección de datos se utilizó la entrevista semi-estructurada y la aplicación de escala. Se identificó bajo nive...

  16. Anormalidades neuropatológicas e neuroquímicas no transtorno afetivo bipolar Neuropathological and neurochemical abnormalities in bipolar disorder

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    Benício Noronha Frey

    2004-09-01

    Full Text Available OBJETIVOS: Estudos pós-mortem, farmacológicos, de neuroimagem e em modelos animais têm demonstrado uma possível associação de mecanismos de sinalização intracelular na fisiopatologia do transtorno afetivo bipolar (TAB. Esse trabalho tem como objetivo revisar os achados em neuropatologia e bioquímica celular. MÉTODOS: Foi realizada uma pesquisa ao MEDLINE, entre 1980 e 2003, tendo sido utilizados os unitermos: bipolar disorder, signaling, second messengers e postmortem, além de referências cruzadas dos artigos selecionados. RESULTADOS: uropatológicos demonstraram uma diminuição do número de células neuronais e gliais, principalmente no córtex pré-frontal de pacientes bipolares. Estudos neuroquímicos demonstraram alterações nas vias do AMPc, fosfatidilinositol, Wnt/GSK-3beta e Ca++ intracelular nesses pacientes. CONCLUSÃO: Os achados de alterações neuropatológicas e neuroquímicas no TAB podem estar relacionados com a fisiopatologia deste transtorno e com os efeitos dos estabilizadores de humor. No entanto, mais estudos são necessários para esclarecer o papel das cascatas de sinalização intracelular na patogênese deste transtorno.OBJECTIVES: Postmortem, pharmacological, neuroimaging, and animal model studies have demonstrated a possible association of intracellular signaling mechanisms in the pathophysiology of bipolar disorder. The objective of this paper is to review the findings in neuropathology and cellular biochemistry. METHODS: We performed a MEDLINE research, between 1980-2003, using bipolar disorder, signaling, second messengers, and postmortem as keywords, and cross-references. RESULTS: Neuropathological studies reported a decrease in neuronal and glial cells, mainly in the prefrontal cortex of bipolar patients. Neurochemical studies reported dysfunction in cAMP, phosphoinositide, Wnt/GSK-3b, and intracellular Ca++ pathways in these patients. CONCLUSION: The neuropathological and neurochemical abnormalities

  17. TERAPÊUTICA MEDICAMENTOSA: CONHECIMENTO E DIFICULDADES DE FAMILIARES DE PESSOAS IDOSAS COM TRANSTORNO AFETIVO BIPOLAR

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    Maristela Monteschi

    2010-01-01

    Full Text Available Este estudio cualitativo y cuantitativo tuvo como objetivo determinar el grado de conocimiento y las dificultades de los familiares de ancianos con Trastorno Afectivo Bipolar relacionados al tratamiento farmacológico prescrito al paciente. Participaron del estudio 17 familiares de ancianos con Trastorno Afectivo Bipolar que reciben atención en un Servicio de Salud Mental. Para la recolección de datos se utilizó la entrevista semi-estructurada y la aplicación de escala. Se identificó bajo nivel de conocimiento de los familiares, especialmente acerca de las dosis y frecuencia de los medicamentos prescritos. Entre las dificultades relacionadas al tratamiento farmacológico, relatadas por los familiares, se destacan la ambigüedad en relación a la evaluación de los beneficios del medicamento, no adherencia de pacientes al medicamento, sobrecarga relacionada con la atención referente a los medicamentos, tratamiento inadecuado, preocupación con el acceso al medicamento y utilización de bebida alcohólica por los pacientes. Son necesarias acciones educativas junto a las familias, como colaboradoras y blanco de las intervenciones, y su inclusión en la atención ofrecida al paciente

  18. Transtorno afetivo bipolar em idosos: características clínicas e sociodemográficas = Bipolar disorder in the elderly: clinical and socio-demographic characteristics

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    Zung, Stevin

    2009-01-01

    Conclusões: o presente estudo, conduzido em pacientes idosos com transtorno afetivo bipolar, confirmou achados clínicos importantes de investigações realizadas em pacientes adultos, acrescentando o fato inédito de consolidar esses achados através da investigação em uma população de pacientes idosos com longo tempo de evolução de seu quadro clínico

  19. Fisiopatologia do transtorno afetivo bipolar: o que mudou nos últimos 10 anos? Physiopathology of bipolar disorders: what has changed in the last 10 years?

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    Flávio Kapczinski

    2004-10-01

    Full Text Available Apesar dos crescentes esforços para o entendimento da neurobiologia do transtorno afetivo bipolar (TAB, sua exata fisiopatologia permanece indeterminada. Inicialmente, a pesquisa estava voltada para o estudo das aminas biogênicas, devido aos efeitos dos diversos agentes psicofarmacológicos. Mais recentemente, evidências apontam que disfunções nos sistemas de sinalização intracelular e de expressão gênica podem estar associadas ao TAB. Estas alterações podem estar associadas a interrupções nos circuitos reguladores do humor, como sistema límbico, estriado e córtex pré-frontal, sendo que os efeitos neuroprotetores do uso crônico dos estabilizadores de humor podem reverter este processo patológico. Este artigo tem como objetivo trazer uma atualização dos achados recentes sobre a neuroquímica do TAB.Despite recent efforts to understand the neurobiology of Bipolar Disorder (BD, the exact pathophysiology remains undetermined. Due to the effects of various psychopharmacological agents, initial research focused on the study of biogenic amines. Recent evidence has shown that dysfunction in intracellular signaling systems and gene expression may be associated with BD. These alterations may cause interruptions in mood regulating circuits such as the limbic system, striatum and prefrontal cortex, and the neuroprotective effects of mood stabilizers may reverse this pathological process. This study aims to update the recent findings relative to the neurochemistry of BD.

  20. Transtorno afetivo bipolar em idosos: características clínicas e sociodemográficas = Bipolar disorder in the elderly: clinical and socio-demographic characteristics

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    Zung, Stevin

    2009-01-01

    Objetivos: descrever as características clínicas, psiquiátricas e sociodemográficas de pacientes idosos com transtorno afetivo bipolar Métodos: foram selecionados pacientes com transtorno bipolar, com idade maior ou igual a 60 anos. Suas características clínicas e sociodemográficas foram obtidas por meio de consulta aos prontuários médicos, bem como através de entrevista com cada paciente e pelo menos com um familiar próximo Resultados: uma amostra de 135 indivíduos foi incluída no estu...

  1. Transtorno afetivo bipolar e a ambivalência em relação à terapia medicamentosa: analisando as condições causais

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    Adriana Inocenti Miasso

    2011-04-01

    Full Text Available Este estudo buscou compreender as condições causais da ambivalência da pessoa com transtorno afetivo bipolar (TAB em relação ao seguimento da terapêutica medicamentosa. Foi utilizada a abordagem qualitativa, tendo como referencial metodológico a Teoria Fundamentada nos Dados, à luz do Interacionismo Simbólico. Participaram do estudo 14 pessoas com TAB que estavam em acompanhamento em um Ambulatório de Transtornos do Humor de um hospital universitário e 14 familiares indicados pelas mesmas. A entrevista e observação foram as principais formas de obtenção de dados. Os resultados revelaram três categorias que descrevem as referidas condições causais: vivendo as crises do transtorno; tendo necessidade do medicamento e convivendo com os efeitos colaterais dos medicamentos. Este estudo aponta para necessidade de mudança de atitude dos profissionais de saúde de culpabilizar o paciente pela interrupção do tratamento para aquela de escuta, de valorização do seu universo simbólico e afetivo bem como de parceria no tratamento.

  2. Implicações de um grupo de Psicoeducação no cotidiano de portadores de Transtorno Afetivo Bipolar

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    Sarita Lopes Menezes

    2012-02-01

    Full Text Available Há evidências crescentes de que o curso Transtorno Afetivo Bipolar (TAB pode ser modificado por abordagens psicoterápicas, tais como a Psicoeducação. Assim, o objetivo deste trabalho foi identificar as implicações do grupo de Psicoeducação no cotidiano dos portadores. Para tanto, optou-se pelo estudo qualitativo, do tipo Estudo de Caso. Foram incluídos doze portadores de TAB que tiveram pelo menos seis participações no Grupo de Psicoeducação desenvolvido na Faculdade de Medicina de São José do Rio Preto (FAMERP. Foram realizadas entrevistas semi-estruturadas, gravadas, transcritas e trabalhadas por meio da Análise Temática. Este estudo demonstrou que tal experiência grupal favoreceu a aquisição de conhecimento; a conscientização da doença e adesão ao tratamento; a realização de mudanças positivas na vida; a possibilidade de ajudar outros portadores a se beneficiarem do aprendizado construído no grupo; a descoberta de outras realidades e estratégias de enfrentamento, obtidas por meio da troca de experiências entre os participantes.

  3. Grupo de psicoeducação no transtorno afetivo bipolar: reflexão sobre o modo asilar e o modo psicossocial

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    Sarita Lopes Menezes

    2011-08-01

    Full Text Available O Transtorno Afetivo Bipolar (TAB, conhecido por sua cronicidade, complexidade e altos índices de morbidade e mortalidade, é uma das principais causas de incapacitação no mundo. Há evidências crescentes de que seu curso pode ser modificado por abordagens psicoterápicas como a psicoeducação, que promove o aumento do funcionamento social e ocupacional, bem como da capacidade de manejarem situações estressantes. Trata-se de um relato de experiência sobre um grupo de psicoeducação para familiares e portadores de TAB, sendo esse pautado pela reflexão dos componentes do paradigma das práticas em saúde mental. A reflexão sobre os modos asilar e psicossocial quanto às concepções de objeto e modo de trabalho, possibilitou situar o grupo no modo psicossocial, pois o conhecimento e a vivência experimentados favorecem a autonomia dos sujeitos, que têm maiores chances de se posicionarem frente às dificuldades que lhes sobrevêm na sua existência-sofrimento.

  4. Relação entre impulsividade e suícidio em pacientes com transtorno afetivo bipolar

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    Paulo Henrique Paiva de Moraes

    2011-01-01

    Diversos estudos investigaram a possível relação entre tentativas de suicídio e a impulsividade em pacientes com transtorno bipolar, mas os resultados sempre foram conflitantes. Esta ausência de resultados uniformes pode estar relacionada à questões conceituais e metodológicas assim como à definição de impulsividade. O objetivo desta pesquisa foi avaliar a relação entre impulsividade e tentativas de suicídio em uma amostra de pacientes com transtorno bipolar. O Iowa Gambling Task e o Conners ...

  5. Cognition, affection and interpersonal relationship of women with bipolar disorder / Cognição, afeto e relacionamento interpessoal de mulheres com transtorno afetivo bipolar

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    Carla Luciano Codani Hisatugo; Latife Yazigi; José Alberto Del Porto

    2009-01-01

    The bipolar affective disorder induces incapacitation and social isolation, and might lead to suicide. It was a clinical study of multiple cases using the following instruments: Beck Depression Inventory (BDI), Beck Suicide Inventory (BSI), Hamilton Scale of Depression (HAM-D) and the Rorschach, by Exner's Comprehensive System (CS). The objective was to analyze the affective, cognitive and interpersonal aspects of the patients. Four female out-patients who were previously diagnosed as bipolar...

  6. Bipolar affective disorder and medication therapy: identifying barriers Trastorno afectivo bipolar y por terapia medicamentoso: identificación de barreras Transtorno afetivo bipolar e terapêutica medicamentosa: identificando barreiras

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    Adriana Inocenti Miasso

    2008-08-01

    barreiras enfrentadas pela pessoa com Transtorno Afetivo Bipolar (TAB frente à necessidade de uso contínuo de medicamentos. Foi utilizada a abordagem qualitativa, tendo como referencial metodológico a Teoria Fundamentada nos Dados, à luz do Interacionismo Simbólico. Participaram do estudo 14 pessoas com TAB que estavam em acompanhamento em um ambulatório de transtornos do humor de um hospital universitário e 14 familiares indicados pelas mesmas. A entrevista e observação foram as principais formas de obtenção de dados. Os resultados revelaram duas categorias que descrevem as barreiras enfrentadas pela pessoa com TAB: ter perdas afetivas e cognitivas e ter várias limitações. Constatou-se que a pessoa com TAB sente-se ambivalente em relação à adesão à terapêutica medicamentosa, pois percebem que, qualquer que seja a direção adotada, ela o conduzirá a um contexto de preconceito, de perdas e limitações nas várias esferas da vida cotidiana.

  7. O RELACIONAMENTO TERAPÊUTICO NO CUIDADO A UMA PORTADORA DE TRANSTORNO AFETIVO BIPOLAR: UMA EXPERIÊNCIA TRANSFORMADORA

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    ANA CLAUDIA SILVA LEMOS

    2007-01-01

    Full Text Available La condensación de las conjeturas de la Reforma Psiquiátrica está – continuamente – transformando la asistencia y enseñanza de la salud mental. El estudio objetiva relatar, durante diez encuentros en un Hospital Día de Fortaleza, una experiencia académica de asistencia de enfermería psiquiátrica, intermediada por el proceso de Relacionamiento Terapéutico preconizado por Stefanelli, en una cliente acometida por Trastorno Afectivo Bipolar (TAB. El instrumento adoptado en la recolección de datos fue la observación participativa, el diario de campo y el histórico de enfermería. Se observó, ante el caso relatado, que el TAB es una sicopatología multifactorial, de carácter multifactorial, exigiendo así del enfermero una visión integrada en la implementación de los cuidados. Dentro de esta perspectiva, la Relación Terapéutica fue el método que promovió un vínculo breve, pero transformador de pensamientos, actitudes y reflexiones en la cliente. La experiencia fue importante, incluso, en la modificación de paradigmas personales sobre el cuidado psiquiátrico y en la comprensión de la enfermedad de la sanidad humana.

  8. Cognition, affection and interpersonal relationship of women with bipolar disorder / Cognição, afeto e relacionamento interpessoal de mulheres com transtorno afetivo bipolar

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    Carla Luciano Codani Hisatugo

    2009-01-01

    Full Text Available The bipolar affective disorder induces incapacitation and social isolation, and might lead to suicide. It was a clinical study of multiple cases using the following instruments: Beck Depression Inventory (BDI, Beck Suicide Inventory (BSI, Hamilton Scale of Depression (HAM-D and the Rorschach, by Exner's Comprehensive System (CS. The objective was to analyze the affective, cognitive and interpersonal aspects of the patients. Four female out-patients who were previously diagnosed as bipolar depressive, by the Psychiatry Interview according to Diagnostic and Statistical Manual of Mental Disorders (SCIDI/CV-DSM-IV criteria were studied. Results had indicated undervalued feelings about themselves, euphoric contents and lack of insight about the self-tolerance related to stress controls. Emotional and cognitive aspects have influenced the interpersonal context leading to increased suffering. Other qualitative and clinic data have been observed and commented.

  9. Ajuste social em pacientes com transtorno afetivo bipolar, unipolar, distimia e depressão dupla Social disability in patients with bipolar and unipolar affective disorders, dysthymia and double depression

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    Adriana M Tucci

    2001-06-01

    Full Text Available OBJETIVOS: Dados internacionais mostram que os transtornos afetivos têm uma prevalência de, aproximadamente, 11,3% da população. Além disso, são uma das doenças que mais geram perdas sociais e nos relacionamentos familiares. O objetivo deste trabalho foi avaliar o ajuste social e familiar de pacientes com transtornos afetivos (bipolar, unipolar, distimia e com depressão dupla, comparando o resultado entre as categorias diagnósticas, além de verificar quais variáveis estão associadas e conduzem ao pior ajuste. MÉTODOS: Foram feitos a caracterização socioeconômica e demográfica e um levantamento dos dados de evolução e de história da doença por meio de um questionário elaborado para essa finalidade. Para a avaliação de ajuste social, utilizou-se a Escala de Avaliação da Incapacitação Psiquiátrica (DAS/OMS, 1998. O relacionamento familiar foi avaliado pelo Global Assessment of Relational Functioning Scale (GARF/APA, 1994. Foram estudados 100 pacientes em tratamento, por pelo menos seis meses, no Ambulatório de Psiquiatria da Faculdade de Medicina Unesp, Botucatu, SP. RESULTADOS/CONCLUSÕES: Com predomínio de mulheres, a maioria dos pacientes tinha no mínimo dois anos de seguimento, idade acima de 50 anos, baixa escolaridade e nível socioeconômico baixo. Não houve diferença estatística significativa quanto aos dados socioeconômicos e demográficos. Na análise de regressão logística, o diagnóstico e o relacionamento familiar tiveram papel significativo no resultado de ajustamento social. Os pacientes unipolares e os distímicos tiveram melhores resultados no ajustamento social e no relacionamento familiar do que os bipolares e aqueles com depressão dupla.OBJECTIVES: International data show that affective disorders have a prevalence of 11.3% in the general population. Besides that, they are responsible for social dysfunctioning and family relationship distress. The aim of this study was to assess social and

  10. Traços de temperamento associados ao transtorno afetivo bipolar: uma revisão integrativa da literatura Temperament traits associated with bipolar affective disorder: an integrative literature review

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    Alina Gomide Vasconcelos

    2011-01-01

    Full Text Available Estudos associam características do temperamento ao mau ajustamento e desenvolvimento de transtornos psiquiátricos, entendendo-os como aspectos de vulnerabilidade à psicopatologia. O objetivo deste estudo é realizar uma revisão integrativa da literatura a respeito dos traços de temperamento que caracterizam o transtorno afetivo bipolar em relação à população geral. Para tanto, foi realizada uma pesquisa sistemática sobre o tema nas bases de dados MEDLINE, PsycINFO e LILACS, utilizando os descritores bipolar disorder, temperament e/ou personality, no período compreendido entre janeiro de 2000 e dezembro de 2010. A consulta às bases de dados foi realizada em janeiro de 2011. A busca resultou em 199 artigos potenciais para compor a revisão. Após aplicação dos critérios de exclusão, 15 artigos foram selecionados para revisão e analisados na íntegra. Dentre os estudos selecionados, notou-se heterogeneidade no perfil das amostras e nos traços específicos de temperamento avaliados e respectivos instrumentos utilizados. Características de temperamento de pacientes bipolares são identificadas com base em diferentes modelos teóricos. De forma congruente, os resultados de cinco estudos apontaram que pacientes bipolares apresentam características relacionadas ao traço de personalidade denominado neuroticismo. Revisões futuras devem utilizar descritores mais específicos e restringir a busca a estudos com delineamento longitudinal.Studies have suggested an association between temperament characteristics and adjustment and psychiatric disorders, describing them as different manifestations of vulnerability to psychopathology. The objective of this study was to conduct an integrative review of the literature on temperament traits typical of bipolar patients in relation to the general population. A systematic search was conducted on the MEDLINE, PsycINFO and LILACS databases, using the headings bipolar disorder, temperament and

  11. Genética dos transtornos afetivos

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    Ivanor Velloso Meira Lima

    2004-01-01

    Full Text Available Os autores revisam neste artigo o conjunto de evidências genético-epidemiológicas que indicam a presença de fatores genéticos na vulnerabilidade para os transtornos afetivos. Apresentam também os dados obtidos até o momento, através de estratégias de genética molecular na busca de genes de susceptibilidade para o transtorno afetivo bipolar e para a depressão.In this article the authors review the body of genetic-epidemiological evidences for the role of genes in mood disorders. Current molecular genetic studies searching for susceptibility genes for bipolar affective disorder and depression are also presented.

  12. Comportamento suicida no transtorno afetivo bipolar e características sociodemográficas, clínicas e neuroanatômicas associadas

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    Fabiana Nery-Fernandes

    2013-01-01

    Full Text Available CONTEXTO: Pacientes com transtorno bipolar possuem risco maior de suicídio, quando comparados com a população geral e com outros transtornos psiquiátricos. Este artigo tem como objetivo revisar os aspectos sociodemográficos, clínicos e neuroanatômicos associados ao comportamento suicida em pacientes com transtorno bipolar com história de tentativa de suicídio. MÉTODOS: Revisão não sistemática da literatura, por meio dos indexadores eletrônicos: PsycoInfo, Lilacs,Medline e PubMed, utilizando-se as palavras-chave: "attempt suicide", "suicidal behavior", "suicide", "bipolar disorder", "suicide risk factor", "neuroimaging" e "suicide neurobiology". RESULTADOS: Diversas características sociodemográficas e clínicas têm sido associadas às tentativas de suicídio em pacientes bipolares, porém os resultados são ainda conflitantes. Em relação aos achados de neuroimagem, os dados também são escassos e inconsistentes. Destes, a hiperintensidade periventricular em substância branca e as alterações na estrutura e função do córtex pré-frontal são os mais descritos. CONCLUSÕES: Considerando que o suicídio é uma causa potencialmente evitável de morte, a compreensão dos correlatos clínicos e neurobiológicos do comportamento suicida pode ser útil na prevenção desse comportamento. Sendo assim, estudos que avaliem melhor os fatores de risco para o comportamento suicida nessa população são necessários.

  13. Suicidal ideation and suicide attempts in bipolar disorder type I: an update for the clinician Ideação suicida e tentativas de suicídio no transtorno afetivo bipolar tipo I: uma atualização para o clínico

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    Lena Nabuco de Abreu

    2009-09-01

    Full Text Available OBJECTIVE: This article reviews the evidence for the major risk factors associated with suicidal behavior in bipolar disorder. METHOD: Review of the literature studies on bipolar disorder, suicidal behavior and suicidal ideation. RESULTS: Bipolar disorder is strongly associated with suicide ideation and suicide attempts. In clinical samples between 14-59% of the patients have suicide ideation and 25-56% present at least one suicide attempt during lifetime. Approximately 15% to 19% of patients with bipolar disorder die from suicide. The causes of suicidal behavior are multiple and complex. Some strong predictors of suicidal behavior have emerged in the literature such as current mood state, severity of depression, anxiety, aggressiveness, hostility, hopelessness, comorbidity with others Axis I and Axis II disorders, lifetime history of mixed states, and history of physical or sexual abuse. CONCLUSION: Bipolar disorder is the psychiatric condition associated with highest lifetime risk for suicide attempts and suicide completion. Thus it is important to clinicians to understand the major risk factors for suicidal behavior in order to choose better strategies to deal with this complex behavior.OBJETIVO: O artigo revisa as evidências relacionadas aos principais fatores de risco associados ao comportamento suicida no transtorno bipolar. MÉTODO: Revisão de artigos da literatura em transtorno bipolar, tentativa de suicídio e ideação suicida. RESULTADOS: O transtorno bipolar está fortemente associado à presença de ideação suicida e a tentativas de suicídio. Em amostras clínicas, entre 14% e 59% dos pacientes apresentam ideação suicida e entre 25% e 56% têm pelo menos uma tentativa de suicídio ao longo da vida. Aproximadamente 15% a 19% dos pacientes com transtorno afetivo bipolar morrem por suicídio. As causas do comportamento suicida são múltiplas e complexas. Alguns preditores de comportamento suicida vêm sendo demonstrados

  14. Estratégias adotadas por pessoas com Transtorno Afetivo Bipolar e a necessidade de terapêutica medicamentosa Estrategias adoptadas por personas con Trastorno Afectivo Bipolar y la necesidad del uso de medicamentos Strategies adopted by people with Bipolar Affective Disorder and the need for medication

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    Adriana Inocenti Miasso

    2007-06-01

    Full Text Available Este estudo identificou as estratégias adotadas pela pessoa com Transtorno Afetivo Bipolar (TAB diante da necessidade de uso contínuo de medicamentos. Foi utilizada a abordagem qualitativa, tendo como referencial metodológico a Teoria Fundamentada nos Dados, à luz do Interacionismo Simbólico. Participaram do estudo 14 pessoas com TAB que estavam em acompanhamento em uma Unidade Ambulatorial de Transtornos do Humor de um hospital universitário e 14 familiares indicados pelas mesmas. A entrevista e observação foram as principais formas de obtenção de dados. Os resultados revelaram cinco categorias que descrevem as estratégias adotadas pela pessoa com TAB: aderindo à terapêutica medicamentosa; querendo conhecer melhor o transtorno e os medicamentos; participando do grupo de psicoeducação; buscando seus direitos em relação ao acesso ao medicamento e tendo fé. Constatou-se que apesar da ambivalência em relação à adesão ao medicamento, a pessoa com TAB possui potencialidades para conviver com a situação.Este estudio identificó las estrategias adoptadas por personas con Trastorno Afectivo Bipolar (TAB ante la necesidad del uso continuo de medicamentos. Se utilizó un planteamiento cualitativo, teniendo como referencia metodológica la Teoría Basada en los Datos, a la luz de Interacción Simbólica. Participaron del estudio 14 personas con TAB, las cuales estaban en seguimiento en una Unidad Ambulatoria de Trastornos del Humor de un hospital universitario, además de 14 familiares indicados por dichas personas. Las principales formas de obtención de datos fueron la entrevista y la observación. Los resultados revelaron cinco categorías que describen las estrategias adoptadas por las personas con TAB: la adhesión a la terapia medicamentosa; el querer conocer mejor el trastorno y los medicamentos; la participación en el grupo de psico-educación; la búsqueda de sus derechos con relación al acceso al medicamento y la f

  15. Interação entre paciente com transtorno afetivo bipolar e equipe ambulatorial quanto à terapêutica medicamentosa Interacción entre el paciente con trastorno afectivo bipolar y el equipo de consulta externa en relación a la terapéutica medicamentosa Interaction between the patients with bipolar affective disorder and the outpatient team regarding medication therapy

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    Adriana Inocenti Miasso

    2009-10-01

    Full Text Available OBJETIVO: Identificar, na perspectiva da pessoa com transtorno afetivo bipolar (TAB e de seu familiar, como ocorre a interação paciente-equipe de saúde relacionada à terapêutica medicamentosa. MÉTODOS: Foi utilizada a abordagem qualitativa, com referencial metodológico da Teoria Fundamentada nos Dados, à luz do Interacionismo Simbólico. Participaram do estudo 14 pessoas com TAB de um serviço ambulatorial e 14 familiares. Para obtenção dos dados utilizou-se a entrevista e observação. RESULTADOS: Os resultados revelaram três categorias que descrevem o referido processo de interação: identificando falhas nas orientações sobre medicamentos, sentindo necessidade de acolhimento pela equipe de saúde e julgando que o paciente deve ser avaliado na sua individualidade. CONCLUSÃO: Evidenciou-se a necessidade de implementação, nos serviços de saúde, de espaços de acolhimento como forma do paciente enfrentar seu processo saúde-doença.OBJETIVO: Identificar, en la perspectiva de la persona con trastorno afectivo bipolar (TAB y de su familiar, cómo ocurre la interacción paciente - equipo de salud relacionada a la terapéutica medicamentosa. MÉTODOS: Fue utilizado el abordaje cualitativo, con referencial metodológico de la Teoría Fundamentada en los Datos, a la luz del Interaccionismo Simbólico. Participaron del estudio 14 personas con TAB de un servicio de consulta externa y 14 familiares. Para la obtención de los datos se utilizó la entrevista y la observación. RESULTADOS: Los resultados revelaron tres categorías que describen el referido proceso de interacción: identificando fallas en las orientaciones sobre medicamentos, sintiendo necesidad de acogida por parte del equipo de salud y juzgando que el paciente debe ser evaluado en su individualidad. CONCLUSIÓN: Fue evidenciada la necesidad de implementación, en los servicios de salud, de espacios de acogida como forma de que el paciente enfrente su proceso salud

  16. Responsabilidade civil por abandono afetivo

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    Fidélis, Maria de Lourdes

    2013-01-01

    Este estudo tem por objetivo a análise da responsabilidade civil por abandono afetivo na relação paterno-filial a partir de recentes decisões dos tribunais brasileiros. Inicialmente discorre sobre a evolução da família contemporânea. Examina os elementos da responsabilidade civil objetivando uma interseção entre o novo Direito de Família e as transformações no dever de indenizar. A partir de dois casos paradigmáticos escolhidos busca-se encontrar os fundamentos e finalidades das demandas por ...

  17. Relationship between neuropsychological and clinical aspects and suicide attempts in euthymic bipolar patients Relação entre aspectos clínicos e neuropsicológicos e as tentativas de suicídio em pacientes eutímicos com transtorno afetivo bipolar

    OpenAIRE

    Paulo Henrique Paiva de Moraes; Fernando Silva Neves; Alina Gomide Vasconcelos; Isabela M. Magalhães Lima; Mayra Brancaglion; Cristina Yumi Sedyiama; Daniel Fuentes; Marco Aurélio Romano-Silva; Humberto Corrêa; Leandro Fernandes Malloy-Diniz

    2013-01-01

    Some studies have investigated the possible relationship between suicide attempts and impulsivity in patients with bipolar disorder. The objective of this study was to assess the relationship between neuro-psychological and clinical aspects and suicide behavior in euthymic bipolar patients. The Iowa Gambling Task and the Conner's Continuous Performance Test evaluated impulsivity in 95 euthymic bipolar patients - 42 suicide attempters and 115 normal control participants. A factorial analysis e...

  18. Relationship between neuropsychological and clinical aspects and suicide attempts in euthymic bipolar patients Relação entre aspectos clínicos e neuropsicológicos e as tentativas de suicídio em pacientes eutímicos com transtorno afetivo bipolar

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    Paulo Henrique Paiva de Moraes

    2013-01-01

    Full Text Available Some studies have investigated the possible relationship between suicide attempts and impulsivity in patients with bipolar disorder. The objective of this study was to assess the relationship between neuro-psychological and clinical aspects and suicide behavior in euthymic bipolar patients. The Iowa Gambling Task and the Conner's Continuous Performance Test evaluated impulsivity in 95 euthymic bipolar patients - 42 suicide attempters and 115 normal control participants. A factorial analysis evaluated the adequacy of the instruments. Furthermore, a multiple regression analysis was done in order to develop a model to predict suicide attempts. Our results point to a specific type of impulsivity related to making decisions, lack of planning and borderline personality disorder comorbidity. This type of impulsivity is a risk factor for suicide attempts in patients with bipolar disorder.Alguns estudos investigaram a possível relação entre tentativas de suicídio e impulsividade em pacientes com transtorno bipolar. O objetivo do estudo foi avaliar a relação entre características neuropsicológicas e clínicas e o comportamento suicida em pacientes bipolares eutímicos. Utilizamos o Iowa Gambling Task e o Conner's Continuous Performance Test para avaliar a impulsividade em 95 pacientes eutímicos com transtorno bipolar (42 com tentativas de suicídio e 155 controles normais. Uma análise fatorial avaliou a adequação dos instrumentos e foi criado um modelo para previsão do número de tentativas de suicídio usando regressão linear múltipla. Nossos resultados apontam para um tipo específico de impulsividade relacionada à tomada de decisões, falta de planejamento e para a comorbidade Transtorno de Personalidade Borderline. A impulsividade por não planejamento é um fator de risco para tentativas de suicídio em pacientes com Transtorno Bipolar.

  19. Responsabilidade Civil decorrente do Abandono Afetivo

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    Welington Oliveira de Souza Costa

    2015-11-01

    Full Text Available O presente artigo jurídico tem por finalidade demonstrar a aplicabilidade do instituto da responsabilidade civil decorrente do abandono afetivo aos genitores que negligenciem seu cuidado para com os filhos, indenizando-os em razão do dano decorrente. Para tanto, será demonstrada a possibilidade de associação do instituto da responsabilidade dentro do direito de família e os dispositivos aplicáveis, inclusive aqueles relativos à solução de conflitos de princípios, apontando, ainda, a jurisprudência correlata.

  20. Bipolar affective disorder: medication adherence and satisfaction with treatment and guidance by the health team in a mental health service El trastorno afectivo bipolar: adhesión al medicamento y satisfacción con el tratamiento y orientaciones del equipo de salud de un núcleo de salud mental Transtorno afetivo bipolar: adesão ao medicamento e satisfação com o tratamento e orientações da equipe de saúde de um núcleo de saúde mental

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    Adriana Inocenti Miasso

    2009-08-01

    investigación apunta para la necesidad de elaborar estrategias dirigidas a la promoción de la adhesión a la terapia medicamentosa en pacientes con TAB.O transtorno afetivo bipolar (TAB é crônico e requer tratamento medicamentoso para seu controle. Este estudo verificou a adesão de pessoas com TAB à medicação e comparou, entre aderentes e não aderentes, a satisfação quanto à equipe de saúde e tratamento. Participaram do estudo 21 pacientes com TAB atendidos em um Núcleo de Saúde Mental. Foi realizada entrevista com aplicação do teste de Morisky-Green e de um instrumento elaborado pelas pesquisadoras. Os dados foram analisados com abordagem quali-quantitativa. Os resultados mostraram que a maior parte dos pacientes não adere ao tratamento medicamentoso por "comportamento não intencional". A maioria deles afirma satisfação com a efetividade do medicamento e com as informações recebidas sobre o mesmo, mas foram identidificados relatos de efeitos colaterais, dúvidas e falta de motivação para seguir o tratamento. Esta pesquisa aponta para a necessidade de estratégias direcionadas à promoção da adesão à terapia medicamentosa em pacientes com TAB.

  1. Transcultural aspects of bipolar disorder

    OpenAIRE

    Sanches, Marsal; Jorge, Miguel Roberto

    2004-01-01

    Considerando-se que existem diferenças importantes na maneira como as emoções são vivenciadas e expressas em diferentes culturas, a apresentação e o manejo do transtorno afetivo bipolar sofrem influência de fatores culturais. O presente artigo realiza uma breve revisão da evidência referente aos aspectos transculturais do transtorno bipolar.Cultural variations in the expression of emotions have been described. Consequently, there are cross-cultural influences on the diagnosis and management o...

  2. Carga Mental e Ergonomia

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    Fábio Corrêa

    2004-06-01

    Full Text Available Este estudo investiga a utilidade e a possibilidade de uso da base teórica de Carga Mental no trabalho, em uma situação de trabalho específica no que se refere aos seus aspectos ergonômicos.

  3. Processamento cognitivo "Teoria da Mente" no transtorno bipolar Cognitive "Theory of Mind" processing in bipolar disorder

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    Hélio Anderson Tonelli

    2009-12-01

    Full Text Available OBJETIVO: O transtorno afetivo bipolar está associado ao comprometimento funcional persistente. Apesar de muitas pesquisas demonstrarem que bipolares podem apresentar déficits cognitivos, um número menor de trabalhos avaliou o papel de prejuízos no processamento cognitivo social, a Teoria da Mente (relacionado à capacidade de inferir estados mentais, no aparecimento de sintomas e complicações sociais em bipolares. O objetivo deste trabalho é o de revisar sistemática e criticamente a literatura sobre possíveis alterações do processamento Teoria da Mente no transtorno afetivo bipolar. MÉTODO: Foi realizada uma busca na base de dados Medline por trabalhos publicados em língua inglesa, alemã, espanhola ou portuguesa nos últimos 20 anos, utilizando a frase de busca "Bipolar Disorder"[Mesh] AND "Theory of Mind". Foram procurados por estudos clínicos envolvendo indivíduos bipolares e que empregaram uma ou mais tarefas cognitivas desenvolvidas para a avaliação de habilidades Teoria da Mente. Foram excluídos os relatos de caso e cartas ao editor. A busca inicial resultou em cinco artigos, sendo selecionados quatro. Outros quatro foram também selecionados a partir da leitura dos artigos acima. DISCUSSÃO: Os artigos selecionados avaliaram populações de bipolares adultos e pediátricos, incluindo indivíduos eutímicos, maníacos e deprimidos. A maioria dos trabalhos avaliados sugere que existam prejuízos no processamento Teoria da Mente em portadores de transtorno afetivo bipolar e que estes podem estar por trás dos sintomas e dos déficits funcionais do transtorno afetivo bipolar. CONCLUSÃO: Pesquisas futuras a respeito do tema em questão poderão esclarecer muito acerca do papel das alterações sociocognitivas no surgimento dos sintomas do transtorno afetivo bipolar, bem como ajudar no desenvolvimento de estratégias preventivas e terapêuticas do mesmo.OBJECTIVE: Bipolar disorder is associated to persistent functional

  4. Processamento cognitivo "Teoria da Mente" no transtorno bipolar

    OpenAIRE

    Tonelli,Hélio Anderson

    2009-01-01

    OBJETIVO: O transtorno afetivo bipolar está associado ao comprometimento funcional persistente. Apesar de muitas pesquisas demonstrarem que bipolares podem apresentar déficits cognitivos, um número menor de trabalhos avaliou o papel de prejuízos no processamento cognitivo social, a Teoria da Mente (relacionado à capacidade de inferir estados mentais), no aparecimento de sintomas e complicações sociais em bipolares. O objetivo deste trabalho é o de revisar sistemática e criticamente a literatu...

  5. Relacionamentos Afetivo-Familiares em Mulheres com Anorexia e Bulimia

    Directory of Open Access Journals (Sweden)

    Carolina Leonidas

    Full Text Available RESUMOEste estudo teve por objetivo investigar a rede social de apoio de mulheres com anorexia e bulimia, com ênfase em suas relações afetivo-familiares. A amostra foi composta por 12 participantes atendidas em hospital universitário. Os instrumentos utilizados foram: roteiro de entrevista semiestruturada, Mapa de Rede e Genograma. Os resultados indicaram que as redes sociais das participantes têm configuração restrita, com proeminência de membros da família em sua composição. Os relacionamentos familiares oscilam, contudo, entre turbulência e distanciamento afetivo. As relações de afeto mantidas com pais, cônjuges e namorados são marcadas por divergências e insatisfações. A baixa densidade da rede de amizades e o empobrecimento da vida social resultam em isolamento e dificuldades de dar início e/ou manter relacionamentos afetivos duradouros.

  6. Vínculos afetivos de adolescentes borderline e seus pais

    OpenAIRE

    Jordão, Aline Bedin; Ramires, Vera Regina Röhnelt

    2010-01-01

    Este estudo investigou as características dos vínculos afetivos entre adolescentes com indicadores de organização de personalidade borderline e seus pais. Esses adolescentes foram avaliados por meio do procedimento de estudo de casos múltiplos. Além de entrevistas, foram aplicados o Teste Projetivo Rorschach, o Teste do Desenho da Família e o Inventário de Vínculos Parentais. Os resultados apontaram para vinculações afetivas fragilizadas, permeadas por representações de negligências, abandono...

  7. PRUEBAS DE CARGA NO DESTRUCTIVAS EN PILOTES

    OpenAIRE

    LUIS IBAÑEZ MORA

    2008-01-01

    En el presente trabajo se abordan las experiencias en la utilización de la modelación matemática y la realización de pruebas de carga no destructivas en cimentaciones sobre pilotes para evaluar su capacidad de carga. Para ello se exponen los resultados obtenidos en pruebas de carga de más de 200 Toneladas, y la distribución de cargas en una estructura portuaria, evaluando su capacidad resistente. Se establecen comparaciones entre los métodos teóricos de calculo de la capacidad de carga del pi...

  8. Aspectos afetivos e o desempenho acadêmico de escolares

    Directory of Open Access Journals (Sweden)

    Adriana Vilela Jacob

    Full Text Available Objetivou-se caracterizar através do Desenho da Casa-Árvore-Pessoa (HTP e do Teste das Pirâmides Coloridas de Pfister (TPC o funcionamento afetivo de 50 crianças com idade entre 8 e 12 anos, de ambos os sexos, com nível intelectual médio. Elas foram distribuídas em dois grupos de 25 sujeitos, um deles com atraso escolar, e o outro grupo apresentando desempenho escolar satisfatório e idade compatível à série cursada. Observou-se através destas técnicas que o rendimento escolar rebaixado nas crianças do grupo com atraso escolar pareceu relacionado a sentimentos de fracasso e a uma auto-imagem depreciativa. No grupo de crianças sem atraso escolar predominou, uma melhor utilização dos recursos intelectuais e afetivos, contudo associado a elevado nível de exigência. O estudo das variáveis afetivas e sua associação ao rendimento escolar puderam favorecer uma compreensão mais aprofundada da maneira como as crianças estão experimentando esta etapa do desenvolvimento.

  9. PRUEBAS DE CARGA NO DESTRUCTIVAS EN PILOTES

    Directory of Open Access Journals (Sweden)

    LUIS IBAÑEZ MORA

    2008-01-01

    Full Text Available En el presente trabajo se abordan las experiencias en la utilización de la modelación matemática y la realización de pruebas de carga no destructivas en cimentaciones sobre pilotes para evaluar su capacidad de carga. Para ello se exponen los resultados obtenidos en pruebas de carga de más de 200 Toneladas, y la distribución de cargas en una estructura portuaria, evaluando su capacidad resistente. Se establecen comparaciones entre los métodos teóricos de calculo de la capacidad de carga del pilote aislado y modelos matemáticos, así como los resultados de la pruebas de carga a escala real.

  10. Bipolar Disorder

    Science.gov (United States)

    Bipolar disorder is a serious mental illness. People who have it go through unusual mood changes. They go ... The down feeling is depression. The causes of bipolar disorder aren't always clear. It runs in families. ...

  11. Implante imediato com carga imediata

    OpenAIRE

    Fontoura, Ricardo Cauterucci

    2016-01-01

    Dois estágios cirúrgicos, somados a um período de cicatrização de três a seis meses, com a ausência de cargas funcionais foram estabelecidos por Bränemark, em 1977, como protocolo cirúrgico da terapia com implantes osteointegrados. Somente após esse tempo de cicatrização, poderia ocorrer a activação dos implantes e confecção das próteses. O desenvolvimento de vários estudos, com a finalidade de abreviar esse período de cicatrização, a simplificação da terapia restauradora, somados aos avan...

  12. Reacciones de intercambio de carga

    Science.gov (United States)

    Errea, L. F.

    Se discute la validez de diversas metodologías y su aplicación al estudio de procesos de intercambio de carga electrónico entre iones y blancos atómicos y moleculares. Para energías de impacto entre 0.05 y 5 eV / amu se emplea el método cuántico de la Coordenada de Reacción Común (CRC). A mayores energías, se utiliza el método semiclásico iconal con un desarrollo de la función de onda dinámica en estados moleculares adiabáticos, modificados con un factor de traslación común (FTC). Estos estados pueden obtenerse con cálculos ab initio o empleando potenciales modelo. Cuando la ionización compite con la transferencia de carga, la inclusión de pseudoestados en estos desarrollos permite calcular simultáneamente las secciones eficaces de ambos procesos. Otra técnica utilizada es el método estadístico CTMC. En el tratamiento de colisiones ión-molécula (diatómica) contrastamos la aplicabilidad de distintos métodos, desde la llamada aproximación Franck-Condon hasta un desarrollo en estados vibrónicos, pasando por la aproximación súbita vibro-rotacional, obteniéndose secciones eficaces de captura electrónica total y a estados individuales, así como secciones de excitación vibracional a estados ligados y del continuo (disociación). En todos los casos es necesario calcular superficies de energía y los correspondientes acoplamientos dinámicos entre los estados. La aplicación de estos métodos permite determinar el grado de contaminación de los haces por estados metaestables en un experimento dado, el cambio en los resultados con diferentes isótopos, la importancia de procesos de doble captura, seguida de explosión culombiana, todo ello con precisión comparable a la de medidas experimentales, para sistemas de interés en distintos tipos de plasmas.

  13. Epidemiologia do transtorno bipolar Epidemiology of bipolar disorders

    Directory of Open Access Journals (Sweden)

    Maurício Silva de Lima

    2005-01-01

    Full Text Available A formulação de políticas em saúde mental depende essencialmente de informações a respeito da freqüência e distribuição dos transtornos mentais. Nas últimas duas décadas, pesquisas de base populacional em epidemiologia psiquiátrica têm sido conduzidas, gerando informações detalhadas sobre freqüência, fatores de risco, incapacidade social e utilização de serviços de saúde. Neste artigo, dados sobre a epidemiologia do transtorno bipolar (TB são discutidos, a partir de resultados de recentes pesquisas populacionais: o estudo da Área de Captação Epidemiológica do Instituto Nacional de Saúde Mental dos Estados Unidos (ECA-NIMH, a Pesquisa Nacional de Comorbidade (NCS, a Pesquisa de Morbidade Psiquiátrica na Grã-Bretanha (OPCS, o Estudo Brasileiro Multicêntrico de Morbidade Psiquiátrica e os estudos longitudinais conduzidos por Angst, em Zurique. As estimativas de prevalências de transtorno bipolar são relativamente baixas, independentemente do lugar onde a pesquisa foi conduzida, do tipo de instrumento diagnóstico usado e dos períodos de tempo para os quais a prevalência se aplica. A partir da introdução do conceito de espectro bipolar, ampliando as fronteiras diagnósticas do TB, as estimativas de prevalências encontradas são substancialmente mais altas. Tais estimativas, entretanto, ainda carecem de validação em estudos populacionais. O transtorno afetivo bipolar é igualmente prevalente entre homens e mulheres, sendo mais freqüente entre solteiros ou separados. Indivíduos acometidos têm maiores taxas de desemprego e estão mais sujeitos a utilizarem serviços médicos e serem hospitalizados. O custo e a eficácia dos tratamentos do TB devem ser balanceados com o alto custo individual e social associados à enfermidade.Information about the epidemiology of bipolar disorders is essential for providing a framework for the formulation of effective mental health policy. In the last two decades, population

  14. Abandono afetivo paterno-filial: a (im) possibilidade de responsabilização civil pelo abandono afetivo dos filhos menores

    OpenAIRE

    Zacchi, Simone Pamplona

    2015-01-01

    O presente trabalho vem tratar da responsabilidade civil aplicada ao Direito de Família no que tange a indenização por abandono afetivo em meio à relação pater¬no-filial. A possibilidade ou não de um filho menor obter do genitor indenização por danos morais e psicológicos em decorrência do abandono afetivo é o tema que define toda a questão a ser abordada. Os princípios basilares para a compreensão da referida obrigação fundam-se na Constituição Federal, bem como no processo evolutivo sofrido...

  15. Escolha de parceiros afetivos: influência das seqüelas de fissura labiopalatal

    Directory of Open Access Journals (Sweden)

    Fernanda Renda Brasil

    2007-12-01

    Full Text Available Adolescentes, fissurados ou não, se vêem diante de sensações novas perante si mesmos e em relação ao sexo oposto durante a busca de parceiros afetivos, estabelecendo critérios para essa seleção. Este estudo objetivou verificar critérios que adolescentes fissurados estabelecem para selecionar parceiros afetivos e se esses diferem dos utilizados pelos seus pares, não fissurados. Participaram, respondendo a um questionário, 74 adolescentes, de 14 a 21 anos, de ambos os sexos, divididos em dois Grupos: Fissurados (GF e Não Fissurados (GNF. Os resultados sugerem que não há diferença significativa entre os grupos considerando as características que valorizam em si e no outro para a escolha do parceiro afetivo. Verificou-se que o GNF valorizou mais o rosto do que o GF, apresentando correlação estatisticamente significativa. Tais resultados permitiram concluir que a fissura interfere na visão de si mesmo ou do outro na busca por parceiros afetivos.

  16. Bipolar disorder

    Science.gov (United States)

    ... of pleasure in activities once enjoyed Loss of self-esteem Thoughts of death or suicide Trouble getting to ... other. This is called rapid cycling. Exams and Tests To diagnose bipolar disorder, the provider may do ...

  17. Bipolar disorder

    Directory of Open Access Journals (Sweden)

    F Colin

    2013-08-01

    Full Text Available Bipolar disorder (BD presents in different phases over time and is oftencomplicated by comorbid conditions such as substance-use disordersand anxiety disorders. Treatment usually involves pharmacotherapywith combinations of different classes of medications and frequentmedication revisions.

  18. ABANDONO AFETIVO DO IDOSO E A RESPONSABILIZAÇÃO CIVIL POR DANO MORAL

    OpenAIRE

    Borin, Roseli Borin; Ite - INSTITUIÇÃO TOLEDO DE ENSINO; Armelin, Priscila Kutne; UNIFAMMA - FACULDADE METROPOLITANA DE MARINGA

    2014-01-01

    RESUMO: O trabalho objetiva buscar a possibilidade de condenação à indenização por danos morais aos casos de abandono afetivo dos filhos em relação aos pais idosos. As modificações familiares promoveram a substituição das relações biológicas pelas afetivas sendo este o núcleo fundamental das relações familiares, a ligação entre seus entes e o motivo pelo qual ela se constrói e se justifica. Assim o abandono afetivo dos idosos vai além do simples abandono, pois gera a responsabilização civil e...

  19. Bipolar Disorder (For Teens)

    Science.gov (United States)

    ... Staying Safe Videos for Educators Search English Español Bipolar Disorder KidsHealth / For Teens / Bipolar Disorder What's in this ... Disorder Print en español Trastorno bipolar What Is Bipolar Disorder? Bipolar disorders are one of several medical conditions ...

  20. Neutrality in bipolar structures

    DEFF Research Database (Denmark)

    Montero, Javier; Rodríguez, J. Tinguaro; Franco, Camilo

    2014-01-01

    In this paper, we want to stress that bipolar knowledge representation naturally allows a family of middle states which define as a consequence different kinds of bipolar structures. These bipolar structures are deeply related to the three types of bipolarity introduced by Dubois and Prade, but our...... approach offers a systematic explanation of how such bipolar structures appear and can be identified....

  1. What is Bipolar Disorder?

    Science.gov (United States)

    ... affect friends and family? For More Information Share Bipolar Disorder Download PDF Download ePub Order a free hardcopy ... brochure will give you more information. What is bipolar disorder? Bipolar disorder is a serious brain illness. It ...

  2. Transtorno bipolar

    Directory of Open Access Journals (Sweden)

    Alda Martin

    1999-01-01

    Full Text Available Os resultados de estudos de famílias sugerem que o transtorno bipolar tenha uma base genética. Essa hipótese foi reforçada em estudos de adoção e de gêmeos. A herança do transtorno bipolar é complexa, envolve vários genes, além de apresentar heterogeneidade e interação entre fatores genéticos e não-genéticos. Achados, que já foram replicados, já implicaram os cromossomos 4, 12, 18 e 21, entre outros, na busca por genes de suscetibilidade. Os resultados mais promissores foram obtidos através de estudos de ligação. Por outro lado, os estudos de associação geraram dados interessantes, mas ainda vagos. Os estudos de populações de pacientes homogêneos e a melhor definição do fenótipo deverão contribuir para avanços futuros. A identificação dos genes relacionados ao transtorno bipolar irá permitir o melhor entendimento e tratamento dessa doença.

  3. ABANDONO AFETIVO: IMPLICAÇÕES NO ÂMBITO DA RESPONSABILIDADE CIVIL

    OpenAIRE

    Trentin, Fernanda; Heinein, Fernanda Rempel

    2014-01-01

    A possibilidade de responsabilizar civilmente pais que abandonam afetivamente um filho vem sendo debatida no cenário jurídico nacional nos últimos anos. O presente artigo buscou analisar a incidência ou não do dever de indenizar por danos morais as situações em que o abandono afetivo for identificado. Para tal escopo, foram analisadas questões introdutórias da responsabilidade civil e fez-se um breve histórico da família e das transformações ocorridas no decorrer dos tempos. Após, estudou-se ...

  4. O abandono afetivo e a possibilidade de indenização por danos morais

    OpenAIRE

    Montenegro, Mariana Lousada Vasconcelos

    2013-01-01

    Na sociedade em que vivemos, o abandono afetivo causado pelos pais pode gerar graves consequências na vida dos seus filhos. Este artigo pretende analisar a possibilidade de reparação por danos morais por motivo de ausência de afeto em uma relação familiar. Serão apresentadas as noções gerais sobre responsabilidade civil, seu conceito e os pressupostos do dever de indenizar. Em seguida, serão expostas as questões relacionadas ao dever social e moral da família, bem como os conceitos desse inst...

  5. Abuso digital nos relacionamentos afetivo-sexuais: uma análise bibliográfica

    OpenAIRE

    Flach, Roberta Matassoli Duran; Deslandes, Suely Ferreira

    2017-01-01

    Resumo: A cultura digital e sua rede de comércio, expandida a partir dos anos 2000 com o advento das plataformas de redes sociais, incita seus partícipes à (hiper) exposição e espetacularização das intimidades, com consequências inerentes à imagem pessoal e à privacidade, publicizando nos meios digitais questões de foro íntimo, especialmente os relativos à sexualidade e corporalidade. Nesse contexto, busca-se compreender como o fenômeno do abuso digital nas relações afetivo-sexuais é conceitu...

  6. A vivência afetivo-sexual de casais inférteis

    OpenAIRE

    Ana Larissa Marques Perissini

    2010-01-01

    A pesquisa aqui relatada foi realizada com 08 casais inférteis em tratamento na Unidade de Medicina Reprodutiva e Imaginologia de um hospital-escola do interior paulista. A fim de compreendermos o instigante fenômeno da infertilidade, acessamos a vivência desses colaboradores mediante uma questão norteadora: Gostaria que você contasse para mim a sua vivência afetivo-sexual durante o namoro, a partir de seu casamento, quando decidiram engravidar, quando perceberam que tinham dificuldade de eng...

  7. Temperamento emocional e afetivo em usuários de álcool

    OpenAIRE

    Leite, Leticia

    2014-01-01

    Não está claro na literatura como o temperamento associa-se a comportamentos relacionados ao consumo de álcool em grandes estudos populacionais. Utilizamos o modelo Affective and Emotional Composite Temperament Scale (AFECTS) para avaliar como traços emocionais e temperamentos afetivos relacionam-se ao uso, abuso e dependência de álcool na população geral. Dados de 10. 603 participantes (média de idade = 28. 0 ± 7. 8 anos, 70,3% mulheres) foram coletados anonimamente pela Internet no Brasil u...

  8. EVALUACIÓN DE LA CARGA FÍSICA POSTURAL Y LA CARGA MENTAL DE UN PARRILLERO-CHEF

    OpenAIRE

    Ariza-Zambrano, Andrea

    2015-01-01

    El presente trabajo de fin de Máster se realizó con el objetivo de evaluar los riesgos de la carga física postural y carga mental a los que se ve expuesto el cargo del Parrillero-chef de un restaurante de comidas rápidas, es un caso real del centro de trabajo Burguer Parrilla & Company en la ciudad de Bogotá, Colombia. Trabajo que se realizó con el interés personal de conocer el nivel de riesgo de carga postural y carga mental al que se encuentra expuesto, ya que el sector de la industria ...

  9. Bipolar disorder: an overview

    African Journals Online (AJOL)

    which is the reason that up to 69% of patients with BD are misdiagnosed.1 Bipolar ... Cyclothymic disorder. • Substance/medication induced bipolar and related disorder. • Bipolar and related disorder due to another medical condition ... patients. Keywords: bipolar disorder, mania, depression, pharmacological management.

  10. Avaliação do temperamento emocional e afetivo em usuários de cocaína

    OpenAIRE

    Fuscaldo, Liane Velloso

    2012-01-01

    JUSTIFICATIVA: Os traços de personalidade contribuem para o comportamento do consumo de drogas, mas seu papel na experimentação, abuso e dependência à cocaína ainda não é claro. Nosso objetivo foi avaliar como os traços emocionais e o temperamento afetivo estavam associados à experimentação, ao abuso, e a dependência à cocaína com uma escala desenvolvida recentemente para a avaliação dos traços emocionais (por ex: Raiva, Vontade) e dos temperamentos afetivos (por ex: ciclotímico). Um levantam...

  11. O lugar do afetivo no desenvolvimento da criança: implicações educacionais

    Directory of Open Access Journals (Sweden)

    Cláudia Aparecida Valderramas Gomes

    2013-09-01

    Full Text Available Este estudo, de natureza teórica, tem por objetivo analisar algumas proposições da Psicologia Histórico-Cultural acerca do psiquismo humano, notadamente no que tange à constituição dos processos afetivos na relação com o desenvolvimento infantil. Para tanto, reúne alguns princípios da filosofia spinosiana que fundamentaram o pensamento de Vigotski sobre os afetos e postula que, para essa escola da psicologia, na base da formação humana se encontram a experiência social e a relação sujeito-objeto, elementos constitutivos dos processos cognitivo e afetivo. As análises desenvolvidas ao longo do texto indicam que os mediadores sociais - signos e instrumentos - subsidiam a formação da atividade e da consciência num processo que legitima a origem histórica e social das funções afetivas. O artigo pretende evidenciar o papel da escola como um espaço privilegiado de acesso aos conhecimentos capazes de transformar os modos de pensar, sentir e agir das crianças por meio dos processos de ensino e de aprendizagem.

  12. Aspectos motivacionais e afetivos na mediação de professores alfabetizadores

    Directory of Open Access Journals (Sweden)

    Azevedo, Cleomar

    2010-01-01

    Full Text Available Este artigo é o resultado de uma pesquisa que parte da seguinte questão: o que diferencia o professor que obtém sucesso no processo de alfabetização? Levanto a hipótese que na mediação os aspectos motivacionais e afetivos são componentes que se fazem presente na atuação desses professores alfabetizadores. O objetivo desta pesquisa foi o de levantar os aspectos motivacionais e afetivos na mediação do processo de alfabetização, através da fala de professores alfabetizadores. Foram entrevistados 18 professores com a premissa de serem bons alfabetizadores. Investigar o que mobiliza e caracteriza a ação dos docentes, que mesmo possuindo inúmeras variáveis que interfiram negativamente nesse processo, conseguem obter êxito no desenvolvimento da alfabetização de seus alunos é uma possibilidade de levantar questões voltadas à problemática da aprendizagem do processo de alfabetização

  13. O afeto que se encerra: urbanização, movimentos, encontros e conflitos afetivos

    Directory of Open Access Journals (Sweden)

    Eduardo Augusto Tomanik

    2016-09-01

    Full Text Available O objetivo do texto será evidenciar e ilustrar como a multiplicidade de interações propiciadas pelos meios urbanos dá origem a processos afetivos complexos e frequentemente contraditórios. Para isto, explorará três conjuntos de fenômenos psicossociais: a as representações, expectativas e promessas de construção de formas de vivência igualitárias e harmoniosas que estiveram presentes nos momentos de construção e de desenvolvimento dos meios urbanos; b as diferenças dos processos afetivos vivenciados por que sempre morou e conviveu nas grandes cidades e por aqueles, originários de outros ambientes sociais, que se vêm atraídos ou obrigados a passar a viver nelas e também os processos simultâneos de satisfação/ insatisfação e de pertencimento/ estranhamento gerados pelos contatos diários de seus moradores na metrópole e com ela e c algumas das condições atuais que propiciam o surgimento e a exacerbação de afetos como o medo e a agressividade nos grandes centros urbanos.

  14. Bipolar Items

    Directory of Open Access Journals (Sweden)

    Nishiguchi Sumiyo

    2016-12-01

    Full Text Available This article asserts that the Japanese wide-scope mo ‘even’ in simple sentences are bipolar items (BPIs antilicensed or forbidden by negation and licensed in a non-monotonic (NM environment. BPIs share the features of negative polarity items (NPIs as well as positive polarity items (PPIs. The Dutch ooit ‘ever’, the Serbo-Croatian i-series ‘and/even’, and the Hungarian is-series ‘and/even’ are antilicensed by clausemate negation and licensed by extraclausal negation (van der Wouden, 1997; Progovac, 1994; Szabolcsi, 2002 or non-monotonic negative (and positive, for Serbo-Croatian emotive predicates. Adding an NPI rescues BPIs in uncomfortable clausemate negation.

  15. O transtorno bipolar na mulher Bipolar disorder in women

    Directory of Open Access Journals (Sweden)

    Alexandro de Borja Gonçalves Guerra

    2005-01-01

    Full Text Available Diferenças sexuais, descritas em vários transtornos psiquiátricos, também parecem estar presentes no transtorno afetivo bipolar (TAB. A prevalência do TAB tipo I se distribui igualmente entre mulheres e homens. Mulheres parecem estar sujeitas a um risco maior de ciclagem rápida e mania mista, condições que fariam do TAB um transtorno com curso mais prejudicial no sexo feminino. Uma diátese depressiva mais marcante, uso excessivo de antidepressivos e diferenças hormonais surgem como hipóteses para explicar essas diferenças fenomenológicas, apesar das quais, mulheres e homens parecem responder igualmente ao tratamento medicamentoso. A indicação de anticonvulsivantes como primeira escolha em mulheres é controversa, a não ser para o tratamento da mania mista e, talvez, da ciclagem rápida. O tratamento do TAB na gravidez deve levar em conta tanto os riscos de exposição aos medicamentos quanto à doença materna. A profilaxia do TAB no puerpério está fortemente indicada em decorrência do grande risco de recorrência da doença nesse período. Embora, de modo geral, as medicações psicotrópicas estejam contra-indicadas durante a amamentação, entre os estabilizadores do humor, a carbamazepina e o valproato são mais seguros do que o lítio. Mais estudos são necessários para a confirmação das diferenças de curso do TAB entre mulheres e homens e a investigação de possíveis diferenças na efetividade dos tratamentos.Gender differences, described in several psychiatric disorders, seem to be also present in bipolar disorder (BD. The prevalence of bipolar I disorder is equally distributed between women and men. Women seem to be at higher risk for rapid cycling and mixed mania, conditions that could make BD a disorder with a more severe course in the female sex. A marked depressive diathesis among women, greatest use of antidepressants and hormonal differences have been mentioned as hypotheses to explain these

  16. AssociaÃÃes Entre Temperamentos Afetivos E Emocionais, Estilos De Defesa E ManifestaÃÃo PsicopatolÃgica Em Uma Grande Amostra"

    OpenAIRE

    Tauily Claussen D'Escragnolle Taunay

    2014-01-01

    s temperamentos afetivos podem ser considerados a base para o humor, o comportamento e a personalidade, alÃm de manifestaÃÃes subclÃnicas hereditÃrias de transtornos do humor. Recentemente, foi proposto um modelo de temperamento que avalia simultaneamente os temperamentos afetivos e emocionais em uma tentativa de integrar os modelos de temperamento emocional de Cloninger e de temperamentos afetivos de Kraepelin/Kretschmer/Akiskal. De acordo este modelo, existem 12 tipos de temperamentos afeti...

  17. Types of Bipolar Disorder

    Science.gov (United States)

    ... many people have bipolar disorder along with another illness such as anxiety disorder, substance abuse, or an eating disorder. People with ... are sometimes misdiagnosed with schizophrenia. Anxiety and ADHD: ... such as bipolar disorder. Risk Factors Scientists are ...

  18. O PREÇO DO AMOR: A INDENIZAÇÃO POR ABANDONO AFETIVO PARENTAL

    OpenAIRE

    Alves, Ana Jéssica Pereira; URCA

    2013-01-01

    O presente artigo pretende, a partir da análise das transformações fáticas ocorridas na sociedade e no Direito de Família, averiguar a viabilidade da indenização diante do Abandono Afetivo Parental, onde há a possibilidade do filho buscar a via judicial para obter a reparação pelo dano moral e psíquico causado pela ausência amorosa parental durante o seu desenvolvimento. Além de uma breve explanação no que compete aos direitos e deveres delegados na legislação brasileira aos pais para com os ...

  19. Cytokines in bipolar disorder

    DEFF Research Database (Denmark)

    Munkholm, Klaus; Vinberg, Maj; Vedel Kessing, Lars

    2012-01-01

    to affective state. METHODS: We conducted a systemtic review of studies measuring endogenous cytokine concentrations in patients with bipolar disorder and a meta-analysis, reporting results according to the PRISMA statement. RESULTS: Thirteen studies were included, comprising 556 bipolar disorder patients......BACKGROUND: Current research and hypothesis regarding the pathophysiology of bipolar disorder suggests the involvement of immune system dysfunction that is possibly related to disease activity. Our objective was to systematically review evidence of cytokine alterations in bipolar disorder according...

  20. Psychotic and Bipolar Disorders: Bipolar Disorder.

    Science.gov (United States)

    Holder, Sarah D

    2017-04-01

    Bipolar disorder is a severe chronic mental illness that affects a large number of individuals. This disorder is separated into two major types, bipolar I disorder, with mania and typically recurrent depression, and bipolar II disorder, with recurrent major depression and hypomania. Patients with bipolar disorder spend the majority of time experiencing depression, and this typically is the presenting symptom. Because outcomes are improved with earlier diagnosis and treatment, physicians should maintain a high index of suspicion for bipolar disorder. The most effective long-term treatments are lithium and valproic acid, although other drugs also are used. In addition to referral to a mental health subspecialist for initiation and management of drug treatment, patients with bipolar disorder should be provided with resources for psychotherapy. Several comorbidities commonly associated with bipolar disorder include other mental disorders, substance use disorders, migraine headaches, chronic pain, stroke, metabolic syndrome, and cardiovascular disease. Family physicians who care for patients with bipolar disorder should focus their efforts on prevention and management of comorbidities. These patients should be assessed continually for risk of suicide because they are at high risk and their suicide attempts tend to be successful. Written permission from the American Academy of Family Physicians is required for reproduction of this material in whole or in part in any form or medium.

  1. Nutrition and Bipolar Depression.

    Science.gov (United States)

    Beyer, John L; Payne, Martha E

    2016-03-01

    As with physical conditions, bipolar disorder is likely to be impacted by diet and nutrition. Patients with bipolar disorder have been noted to have relatively unhealthy diets, which may in part be the reason they also have an elevated risk of metabolic syndrome and obesity. An improvement in the quality of the diet should improve a bipolar patient's overall health risk profile, but it may also improve their psychiatric outcomes. New insights into biological dysfunctions that may be present in bipolar disorder have presented new theoretic frameworks for understanding the relationship between diet and bipolar disorder. Copyright © 2016 Elsevier Inc. All rights reserved.

  2. Bipolar Treatment: Are Bipolar I and Bipolar II Treated Differently?

    Science.gov (United States)

    ... management strategies. In addition to medications and other types of treatment, successful management of your bipolar disorder includes living a healthy lifestyle, such as getting enough sleep, eating a healthy diet and being physically active. ...

  3. Bipolar soft connected, bipolar soft disconnected and bipolar soft compact spaces

    Directory of Open Access Journals (Sweden)

    Muhammad Shabir

    2017-06-01

    Full Text Available Bipolar soft topological spaces are mathematical expressions to estimate interpretation of data frameworks. Bipolar soft theory considers the core features of data granules. Bipolarity is important to distinguish between positive information which is guaranteed to be possible and negative information which is forbidden or surely false. Connectedness and compactness are the most important fundamental topological properties. These properties highlight the main features of topological spaces and distinguish one topology from another. Taking this into account, we explore the bipolar soft connectedness, bipolar soft disconnectedness and bipolar soft compactness properties for bipolar soft topological spaces. Moreover, we introduce the notion of bipolar soft disjoint sets, bipolar soft separation, and bipolar soft hereditary property and study on bipolar soft connected and disconnected spaces. By giving the detailed picture of bipolar soft connected and disconnected spaces we investigate bipolar soft compact spaces and derive some results related to this concept.

  4. Aspectos afetivos e o desempenho acadêmico de escolares Affective behavior and academic achievement

    Directory of Open Access Journals (Sweden)

    Adriana Vilela Jacob

    1999-08-01

    Full Text Available Objetivou-se caracterizar através do Desenho da Casa-Árvore-Pessoa (HTP e do Teste das Pirâmides Coloridas de Pfister (TPC o funcionamento afetivo de 50 crianças com idade entre 8 e 12 anos, de ambos os sexos, com nível intelectual médio. Elas foram distribuídas em dois grupos de 25 sujeitos, um deles com atraso escolar, e o outro grupo apresentando desempenho escolar satisfatório e idade compatível à série cursada. Observou-se através destas técnicas que o rendimento escolar rebaixado nas crianças do grupo com atraso escolar pareceu relacionado a sentimentos de fracasso e a uma auto-imagem depreciativa. No grupo de crianças sem atraso escolar predominou, uma melhor utilização dos recursos intelectuais e afetivos, contudo associado a elevado nível de exigência. O estudo das variáveis afetivas e sua associação ao rendimento escolar puderam favorecer uma compreensão mais aprofundada da maneira como as crianças estão experimentando esta etapa do desenvolvimento.Using the House-Tree-Person Drawing (HTP and the Color Pyramid Test (CPT we aimed at characterizing the affective behavior of 50 children of average intellectual level, male and female, aged from 8 to 12 years. Two groups of 25 subjects each were formed: one presenting school delay and another with satisfactory school performance and age compatible with school grade. The used techniques showed that low school performance among the children with school delay seemed to be related to feelings of failure and a low self-esteem. In the group with no school delay prevailed a better use of affective and intellectual resources, but associated to high demand. The study of affective variables and their association with school performance lead to a deeper understanding of the way the children are experiencing their developing stage.

  5. Abuso digital nos relacionamentos afetivo-sexuais: uma análise bibliográfica

    Directory of Open Access Journals (Sweden)

    Roberta Matassoli Duran Flach

    Full Text Available Resumo: A cultura digital e sua rede de comércio, expandida a partir dos anos 2000 com o advento das plataformas de redes sociais, incita seus partícipes à (hiper exposição e espetacularização das intimidades, com consequências inerentes à imagem pessoal e à privacidade, publicizando nos meios digitais questões de foro íntimo, especialmente os relativos à sexualidade e corporalidade. Nesse contexto, busca-se compreender como o fenômeno do abuso digital nas relações afetivo-sexuais é conceituado e caracterizado nos estudos científicos, quais agravos à saúde são associados e tecnologias sociais de intervenção são sugeridas. Essa forma de abuso digital é uma nova expressão da violência entre parceiros íntimos que envolve, dentre outras práticas, a disseminação de fotos e vídeos constrangedores e mensagens íntimas sem o consentimento prévio, com o intuito de humilhar e difamar a pessoa. O presente trabalho constitui uma revisão sistemática integrativa, incluindo 35 artigos, predominando os estudos norte-americanos (22. Dentre os tipos de abusos digitais se destacam as formas de agressão direta e controle/monitoramento. Apesar da alta prevalência, especialmente entre adolescentes e jovens, a literatura destaca que a prática desse tipo de abuso digital é muitas vezes naturalizada. As intervenções sugeridas são majoritariamente de prevenção e conscientização acerca dos relacionamentos abusivos, atuação de conselheiros na escola e para a orientação às famílias. A alta reciprocidade da prática do abuso digital nas relações afetivo-sexuais entre homens e mulheres indica que análises futuras devem buscar compreender como as dinâmicas de violência de gênero são aí reproduzidas ou subvertidas.

  6. Reconhecimento dos aspectos tacêsicos para o cuidado afetivo e de qualidade ao idoso hospitalizado

    Directory of Open Access Journals (Sweden)

    Teresa Cristina Gioia Schimidt

    Full Text Available Verificar os aspectos tacêsicos importantes para serem observados ao tocar o idoso. Estudo de campo, qualitativo e exploratório desenvolvido com 117 graduandos e profissionais de saúde participantes da capacitação em comunicação não verbal em gerontologia. Os resultados revelam que a maioria conseguiu identificar, pelo menos, um fator de atenção que precisa ser respeitado ao tocar o idoso. Os discursos permitiram a construção de nove categorias apontando condições necessárias ao cuidado afetivo e de qualidade prestado no âmbito da tacêsica; quais sejam: autorização para que o toque ocorra; localização do toque; intensidade do toque; condição do idoso; intencionalidade e tipo de toque; duração do toque; sexo e idade de quem toca e quem é tocado; frequência do toque e características das mãos que tocam. O tocar faz parte do cotidiano dos profissionais da saúde e expressa zelo e sentimentos consequentemente, revela a qualidade da assistência prestada.

  7. Abandono Afetivo: Afeto e Paternidade em Instâncias Jurídicas

    Directory of Open Access Journals (Sweden)

    Lisandra Espíndula Moreira

    Full Text Available Resumo O objetivo deste artigo é discutir arqueologicamente a articulação entre paternidade e criminalidade, tomando como base um documento jurídico que aciona um pai por abandono afetivo. Em especial, analisamos a produção de sujeitos nos jogos enunciativos que responsabilizam o pai por sua ausência na vida da prole. Para que se construa essa responsabilização em relação ao(a filho(a é necessário que os enunciados se movimentem e estabeleçam diferenciações entre a responsabilidade familiar x de outras instâncias (comunidade e Estado. No interior da instância familiar, os enunciados explicitam a matriz heterossexista, construindo lugares específicos para homens e mulheres, recheados de prescrições, funções e características. Para que se transforme numa demanda jurídica legítima, o afeto será entendido como cuidado e convívio. Mesmo nesta operação enunciativa, o cuidado paterno não se produz de forma semelhante ao cuidado materno. Ao referir-se à paternidade, o afeto (cuidado se transformará na demanda por limite e autoridade, que se sustenta na associação entre a ausência paterna e a criminalidade.

  8. Estrutura fatorial da escala de atitudes frente a relacionamentos afetivos estáveis

    Directory of Open Access Journals (Sweden)

    Taciano Lemos Milfont

    Full Text Available O presente estudo visa contribuir para a comprovação da estrutura fatorial da Escala de Atitudes Frente a Relacionamentos Afetivos Estáveis (RAE; Reis, 1995. Participaram da pesquisa 658 estudantes universitários com idade média 19,9 anos (DP=2,5. Análises fatoriais exploratórias e confirmatórias indicaram a existência de uma estrutura multidimensional. Os cinco fatores encontrados (Comprometimento, Edificação, Mutualidade, Envolvimento e Indulgência apresentaram índices de consistência interna satisfatórios (0,68<α<0,83, itens com saturações altas (0,46<λy<0,75 e significativas (p<0,05. Esta estrutura multidimensional apresentou melhores índices de bondade de ajuste (χ2/gl=3,07; GFI=0,91; CFI=0,97; RMSEA=0,056 e foi estatisticamente superior [Δχ2(111=676,69, p<0,001] à estrutura unidimensional. Resultados de correlações com as auto-imagens independente e interdependente (Singelis, 1994, com os valores humanos básicos (Gouveia, 2003, além de diferenças quanto ao sexo, confirmam a validade dos cinco novos fatores.

  9. PRÁTICAS AFETIVO-SEXUAIS JUVENIS: ENTRE A SUPERFICIALIDADE E O APROFUNDAMENTO AMOROSO

    Directory of Open Access Journals (Sweden)

    Jacqueline Cavalcanti Chaves

    2016-08-01

    Full Text Available Resumo O objetivo deste artigo é analisar algumas questões vinculadas às práticas afetivo-sexuais do "ficar", ficar "ficando" e namorar, assinalando diferenças entre elas. Seu referencial teórico são estudos de diferentes autores das ciências humanas e sociais que abordam essa temática. O campo empírico da pesquisa são entrevistas extensas e semiestruturadas realizadas com doze jovens cariocas de 18 a 25 anos de idade. A partir da análise das entrevistas, pode-se dizer que os jovens diferenciam essas práticas em função do compromisso e envolvimento amoroso com o outro; constroem um jogo cambiante entre sensação/superficialidade e sentimento/profundidade; e, muitas vezes, colocam o outro no lugar de meio de acesso à autossatisfação. As formas como os jovens constroem e vivenciam seus relacionamentos amorosos contribuem para o desenvolvimento de um campo amoroso cada vez mais instável e complexo.

  10. Transtorno afectivo bipolar: perfil fármaco-terapéutico y adhesión a la medicación

    OpenAIRE

    Miasso, Adriana Inocenti; Mercedes, Bruna Paiva do Carmo; Tirapelli, Carlos Renato

    2012-01-01

    Este estudo teve como objetivos verificar a adesão de portadores de transtorno afetivo bipolar (TAB) à terapêutica medicamentosa e identificar possíveis causas de adesão e não adesão ao medicamento de acordo com o perfil farmacoterapêutico. Trata-se de estudo transversal, descritivo, realizado em Núcleo de Saúde Mental de um município do interior paulista. Participaram do estudo 101 pacientes com TAB. Para coleta dos dados, utilizou-se a entrevista estruturada e o teste de Morisky-Green e, pa...

  11. Bipolar Disorder - Multiple Languages

    Science.gov (United States)

    ... MP3 Bipolar Disorder (An Introduction) - English MP4 Bipolar Disorder (An Introduction) - español (Spanish) MP4 Healthy Roads Media Characters not displaying correctly on this page? See language display issues . Return to the MedlinePlus Health Information ...

  12. Magnetic bipolar transistor

    OpenAIRE

    Fabian, Jaroslav; Zutic, Igor; Sarma, S. Das

    2003-01-01

    A magnetic bipolar transistor is a bipolar junction transistor with one or more magnetic regions, and/or with an externally injected nonequilibrium (source) spin. It is shown that electrical spin injection through the transistor is possible in the forward active regime. It is predicted that the current amplification of the transistor can be tuned by spin.

  13. Properties of Bipolar Fuzzy Hypergraphs

    OpenAIRE

    Akram, M.; Dudek, W. A.; Sarwar, S.

    2013-01-01

    In this article, we apply the concept of bipolar fuzzy sets to hypergraphs and investigate some properties of bipolar fuzzy hypergraphs. We introduce the notion of $A-$ tempered bipolar fuzzy hypergraphs and present some of their properties. We also present application examples of bipolar fuzzy hypergraphs.

  14. El quehacer cotidiano de la enfermera significa soportar la carga

    Directory of Open Access Journals (Sweden)

    Martha Adiela Lopera Betancur

    2016-07-01

    Full Text Available Introducción: Las enfermeras le dan significados a su quehacer cotidiano y la comprensión de estos favorece el diseño de propuestas orientadas a promover la calidad, humanización y gestión de los servicios. El objetivo fue comprender el significado que las enfermeras le dan a su quehacer cotidiano. Materiales y Métodos: Se utilizó la investigación cualitativa con enfoque etnográfico, se realizaron entrevistas grupales y se llevó diario de campo. Resultados: Las enfermeras deben apropiarse del servicio, lo que significa realizar cuidado integral y cargar el servicio. Esta carga del servicio es entendida como soportar la carga de la culpa, los problemas, las interacciones, los indicadores y protocolos sin suficiente tiempo. Discusión: El cuidado genera motivación la cual es una emoción capaz de provocar, mantener y dirigir la conducta hacia un objetivo, la carga laboral ha obligado a las enfermeras a dedicar menos tiempo al cuidado lo cual las lleva a sentimientos de culpa, agotamiento y estrés. Conclusiones: El quehacer de enfermería significa una carga cuando sienten que deben encargarse de tareas que no son de su competencia profesional o que son impuestas limitando su autonomía. Tener que soportarla lleva a las enfermeras a la desmotivación. Cómo citar este artículo: Lopera MA, Forero C, Paiva LE, Cuartas VM. El quehacer cotidiano de la enfermera significa soportar la carga. Rev Cuid. 2016; 7(2: 1262-70. http://dx.doi.org/10.15649/cuidarte.v7i2.320

  15. Bipolar Disorder in Children

    Science.gov (United States)

    2014-01-01

    Although bipolar disorder historically was thought to only occur rarely in children and adolescents, there has been a significant increase in children and adolescents who are receiving this diagnosis more recently (Carlson, 2005). Nonetheless, the applicability of the current bipolar disorder diagnostic criteria for children, particularly preschool children, remains unclear, even though much work has been focused on this area. As a result, more work needs to be done to further the understanding of bipolar symptoms in children. It is hoped that this paper can assist psychologists and other health service providers in gleaning a snapshot of the literature in this area so that they can gain an understanding of the diagnostic criteria and other behaviors that may be relevant and be informed about potential approaches for assessment and treatment with children who meet bipolar disorder criteria. First, the history of bipolar symptoms and current diagnostic criteria will be discussed. Next, assessment strategies that may prove helpful for identifying bipolar disorder will be discussed. Then, treatments that may have relevance to children and their families will be discussed. Finally, conclusions regarding work with children who may have a bipolar disorder diagnosis will be offered. PMID:24800202

  16. Bipolar Disorder in Children

    Directory of Open Access Journals (Sweden)

    Kimberly Renk

    2014-01-01

    Full Text Available Although bipolar disorder historically was thought to only occur rarely in children and adolescents, there has been a significant increase in children and adolescents who are receiving this diagnosis more recently (Carlson, 2005. Nonetheless, the applicability of the current bipolar disorder diagnostic criteria for children, particularly preschool children, remains unclear, even though much work has been focused on this area. As a result, more work needs to be done to further the understanding of bipolar symptoms in children. It is hoped that this paper can assist psychologists and other health service providers in gleaning a snapshot of the literature in this area so that they can gain an understanding of the diagnostic criteria and other behaviors that may be relevant and be informed about potential approaches for assessment and treatment with children who meet bipolar disorder criteria. First, the history of bipolar symptoms and current diagnostic criteria will be discussed. Next, assessment strategies that may prove helpful for identifying bipolar disorder will be discussed. Then, treatments that may have relevance to children and their families will be discussed. Finally, conclusions regarding work with children who may have a bipolar disorder diagnosis will be offered.

  17. Comparación de carga inmediata frente a carga convencional de implantes inmediatos con prótesis fijas de arco completo

    OpenAIRE

    Peñarrocha Oltra, David

    2014-01-01

    Comparación de carga inmediata frente a carga convencional de implantes inmediatos con prótesis fijas de arco completo. OBJETIVOS El propósito del estudio fue evaluar las diferencias entre los protocolos de carga inmediata y carga convencional para rehabilitar a pacientes con el maxilar o la mandíbula parcialmente desdentados en los que esté indicada la extracción de todos los dientes remanentes, con prótesis fijas de arco completo sobre implantes dentales inmediatos y no inmediatos, e...

  18. Avaliação psicológica em processos judiciais de abandono afetivo : conflitos familiares e as demandas do judiciário

    OpenAIRE

    Coltro, Beatriz Pires

    2017-01-01

    A indenização por abandono afetivo caracteriza-se como um processo judicial em que um filho move ação solicitando compensação financeira pelos danos morais decorrentes do abandono de um dos genitores. O objetivo deste estudo, retrospectivo documental, foi compreender a dinâmica de processos de indenização por abandono afetivo, identificando a relevância das contribuições da psicologia jurídica nesse tipo de ação. Estudamos em profundidade dois laudos psicológicos decorrentes de avaliações psi...

  19. Adolescentes em tratamento psiquiátrico: um estudo fenomenológico das vivências em seus relacionamentos sócio-afetivos-sexuais

    OpenAIRE

    Fernanda Tomé Marleta Iezzi

    2013-01-01

    RESUMO Marleta-Iezzi, F. T. (2013) Adolescentes em tratamento psiquiátrico: um estudo fenomenológico das vivências em seus relacionamentos sócio-afetivo-sexuais. Dissertação de Mestrado Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto da Universidade de São Paulo, Ribeirão Preto. Na presente dissertação buscamos situar e (re)conhecer o fenômeno das vivências dos relacionamentos sócio-afetivo-sexuais de adolescentes submetidos a tratamento psiquiátrico, por compreender que a adol...

  20. Temperamentos afetivos: aspectos genéticos, familiaridade e aplicação na clínica dos transtornos de humor

    OpenAIRE

    Alexandre de Aguiar Ferreira

    2013-01-01

    A identificação de características do temperamento afetivo tem sido considerada uma questão importante nas manifestações psicopatológicas do humor. O questionário TEMPS-Rio de Janeiro é um instrumento que permite esta identificação nos seguintes tipos: depressivo, ciclotímico, irritado, hipertímico, ansioso e preocupado. O primeiro objetivo do presente estudo foi caracterizar o temperamento afetivo em uma amostra de pacientes com Transtornos de Humor em comparação aos seus familiares e a um g...

  1. Pesquisa e Extensão em Saúde e a Aprendizagem nos Níveis Cognitivo e Afetivo

    Directory of Open Access Journals (Sweden)

    João Luiz Gurgel Calvet da Silveira

    Full Text Available RESUMO O objetivo deste estudo foi comparar a aprendizagem nos níveis cognitivo e afetivo entre alunos bolsistas do programa PET-Saúde e alunos que não tiveram experiência em atividades de pesquisa e extensão. O método utilizado foi um estudo exploratório comparativo com 14 estudantes dos cursos de Medicina, Medicina Veterinária, Odontologia, Nutrição, Fisioterapia, Enfermagem e Educação Física da Universidade Regional de Blumenau. Os temas abordados foram integralidade do cuidado em saúde, pesquisa e extensão. Utilizou-se abordagem qualitativa por meio da técnica de entrevista semiestruturada. A análise foi realizada por meio da taxonomia de Bloom.Os Alunos envolvidos com as atividades de pesquisa e extensão no programa PET-Saúde atingiram maiores níveis da taxonomia de Bloom nos domínios cognitivo e afetivo em comparação com os outros estudantes. A experiência dos estudantes nos grupos PET-Saúde parece contribuir para uma aprendizagem diferenciada nos cursos da saúde.

  2. Genetics of bipolar disorder

    OpenAIRE

    Kerner, Berit

    2014-01-01

    Berit Kerner Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA Abstract: Bipolar disorder is a common, complex genetic disorder, but the mode of transmission remains to be discovered. Many researchers assume that common genomic variants carry some risk for manifesting the disease. The research community has celebrated the first genome-wide significant associations between common single nucleotide polymorphisms (SNPs) and bipolar ...

  3. [Antidepressants in bipolar disorder].

    Science.gov (United States)

    Courtet, P; Samalin, L; Olié, E

    2011-12-01

    Whereas mania defines the bipolar disorder, depression is the major challenge of treatment. In general, depressions are more frequent, longer, with a major prognostic impact in terms of disability and suicide. How should we treat a patient with bipolar depression? Antidepressants are the treatment of choice for depression, but not in the bipolar disorder. In this context, we have traditionally accepted that antidepressants are effective but they were inducing a significant risk of destabilization of the bipolar disorder, because of the transitions to mania and rapid cycling. Current data reconsider both the two aspects of this risk-benefit ratio. The effectiveness of antidepressants finally seems very limited, especially after the more recent studies with a robust methodology. Manic switches and rapid cycling may not be increased, particularly with new antidepressants and mood stabilizer combinations. The current literature reminds us that these course's modalities are inherent to the disease, with numerous risk factors, and among them, exposure to antidepressants. Who are the bipolar patients who only get the benefits of antidepressant treatment? Research will tell. They are in any case limited. How to navigate in our treatment strategies ? By choosing first drugs that demonstrated efficacy in bipolar depression. When the situation is more complex, "primum non nocere" should lead to support the prescription of the antidepressant in association with mood stabilizer. Copyright © 2011 L’Encéphale. Published by Elsevier Masson SAS.. All rights reserved.

  4. Dos modelos del transporte de carga por carretera

    Directory of Open Access Journals (Sweden)

    Carlos Esteban Posada

    1993-07-01

    Full Text Available El repunte de las operaciones comerciales con el exterior, acentuado por el extraordinario volumen de café para exportación, ha mostrado la insuficiencia del sistema de transporte terrestre del país: se aumentaron en forma inusual los fletes de transporte de carga desde y hacia los puertos.En el presente artículo, mediante la presentación de dos modelos matemáticos de transporte de carga por carretera, se establecen algunos elementos para avalar la importación de “tractomulas” de segunda, como una política global que le permitiría al país incrementar los costos de transporte a los demás sectores económicos.

  5. Estructuras de elevadores de carga. // Dumbwaiter structure stress analysis.

    Directory of Open Access Journals (Sweden)

    G. Escobar Travieso

    2004-05-01

    Full Text Available Este trabajo tiene como objetivo analizar las tensiones y deformaciones que ocurren en las estructuras del marco de carro,plataforma y cabina de elevadores de carga mediante la aplicación del Método de los Elementos Finitos, específicamentedel montaplatos de 300 Kg. de capacidad, con vista a realizar el análisis de resistencia, racionalización del peso y material ylas posibles vías de solución.Palabras claves: Elevador de carga, estructuras, análisis de tensiones, elementos finitos._______________________________________________________________________________AbstractThis paper deals with the tension and deformation analysis in structures of lifter mark, platform and cabin offreight lifters by means of the Finite Elements Method, specifically the 300 kgs capacity dumbwaiter, in orderto carry out the resistance analysis, weight and material rationalization.Key words: Dumbwaiter, structures, stress analysis, finite elements.

  6. Estructuras de elevadores de carga. // Dumbwaiter structure stress analysis.

    Directory of Open Access Journals (Sweden)

    G. Escobar Travieso

    2006-09-01

    Full Text Available Este trabajo tiene como objetivo analizar las tensiones y deformaciones que ocurren en las estructuras del marco de carro,plataforma y cabina de elevadores de carga mediante la aplicación del Método de los Elementos Finitos, específicamentedel montaplatos de 300 Kg. de capacidad, con vista a realizar el análisis de resistencia, racionalización del peso y material ylas posibles vías de solución.Palabras claves: Elevador de carga, estructuras, análisis de tensiones, elementos finitos.________________________________________________________________________________AbstractThis paper deals with the tension and deformation analysis in structures of lifter mark, platform and cabin offreight lifters by means of the Finite Elements Method, specifically the 300 kgs capacity dumbwaiter, in orderto carry out the resistance analysis, weight and material rationalization.Key words: Dumbwaiter, structures, stress analysis, finite elements.

  7. Cargas actuantes en túneles de Moa

    Directory of Open Access Journals (Sweden)

    Roberto Blanco-Torrens

    2000-03-01

    Full Text Available Para la confección del presente trabajo se realizó un estudio que abarcó 2 km de túneles del municipio Moa a los que se les hizo un análisis detallado del macizo rocoso que los circunda, y se determinaron las propiedades físico-mecánica de las rocas, agrietamiento, afluencia de agua y sus consecuencias, etc. Se valoró la estabilidad por varias metodologías (Barton, Bieniawsky, Bulichev y otras y fueron usados, por sus resultados, los valores obtenidos del empleo de la de Barton. Se estableció el mecanismo de acción de la presión minera y se caracterizó en dos casos típicos, a partir de los cuales se determinan los valores de las cargas estáticas que se pueden producir. Se consideró el macizo como un cuerpo elástico, homogéneo e isotrópico para establecer el estado tensional inicial y así calcular las cargas dinámicas que pueden actuar. Además se puntualizan los valores de las cargas considerados como críticos.

  8. Depression and Bipolar Support Alliance

    Science.gov (United States)

    Depression and Bipolar Support Alliance Crisis Hotline Information Coping with a Crisis Suicide Prevention Information Psychiatric Hospitalization ... sign-up Education info, training, events Mood Disorders Depression Bipolar Disorder Anxiety Screening Center Co-occurring Illnesses/ ...

  9. Bipolar Affective Disorder and Migraine

    Directory of Open Access Journals (Sweden)

    Birk Engmann

    2012-01-01

    Full Text Available This paper consists of a case history and an overview of the relationship, aetiology, and treatment of comorbid bipolar disorder migraine patients. A MEDLINE literature search was used. Terms for the search were bipolar disorder bipolar depression, mania, migraine, mood stabilizer. Bipolar disorder and migraine cooccur at a relatively high rate. Bipolar II patients seem to have a higher risk of comorbid migraine than bipolar I patients have. The literature on the common roots of migraine and bipolar disorder, including both genetic and neuropathological approaches, is broadly discussed. Moreover, bipolar disorder and migraine are often combined with a variety of other affective disorders, and, furthermore, behavioural factors also play a role in the origin and course of the diseases. Approach to treatment options is also difficult. Several papers point out possible remedies, for example, valproate, topiramate, which acts on both diseases, but no first-choice treatments have been agreed upon yet.

  10. Depressive and bipolar disorders

    DEFF Research Database (Denmark)

    Kessing, Lars Vedel; Hansen, Hanne Vibe; Demyttenaere, Koen

    2005-01-01

    BACKGROUND: There is increasing evidence that attitudes and beliefs are important in predicting adherence to treatment and medication in depressive and bipolar disorders. However, these attitudes have received little study in patients whose disorders were sufficiently severe to require...... hospitalization. METHOD: The Antidepressant Compliance Questionnaire (ADCQ) was mailed to a large population of patients with depressive or bipolar disorder, representative of patients treated in hospital settings in Denmark. RESULTS: Of the 1005 recipients, 49.9% responded to the letter. A large proportion....... Moreover, their partners agreed on these negative views. Women had a more negative view of the doctor-patient relationship than men, and patients with a depressive disorder had a more negative view of antidepressants than patients with bipolar disorder. The number of psychiatric hospitalizations...

  11. Avaliação do desenvolvimento cognitivo e afetivo-social de crianças com perda auditiva

    Directory of Open Access Journals (Sweden)

    Maria de Lourdes M. Tabaquim

    2013-12-01

    Full Text Available OBEJTIVO: avaliar o nível de desenvolvimento cognitivo e afetivo-social de crianças com diagnóstico de deficiência auditiva. MÉTODO: participaram do estudo 50 crianças com diagnóstico de deficiência auditiva, com idade média de 16,1 meses, de ambos os gêneros. Empregou-se a entrevista semi-estruturada com os pais para a obtenção da história de vida da criança, a Escala de Desenvolvimento Comportamental e a Escala de Avaliação da Reação de Retração do Bebê. RESULTADO: o estudo identificou 80% das crianças com perda auditiva profunda bilateral. O Quociente de Desenvolvimento na normalidade ocorreu em 76% da amostra, sendo as funções da linguagem e pessoal-social, as mais prejudicadas. Os níveis de ajustamento afetivo e interacional foram caracterizados pelas reações de alarme para problemas de interação pessoal-social. CONCLUSÃO: as competências defasadas de habilidades verbais e não-verbais mostraram implicações no desenvolvimento cognitivo, sugestivas da condição da criança com perda auditiva e dos fatores de risco associados, com limitação circunstancial a trocas comunicativas que promovem o desenvolvimento de competências adaptativas e o fortalecimento da auto-estima para as relações.

  12. Marcadores periféricos e a fisiopatologia do transtorno bipolar

    OpenAIRE

    Pedro V. S. Magalhães; Gabriel R. Fries; Flávio Kapczinski

    2012-01-01

    INTRODUÇÃO: O entendimento da fisiopatologia do transtorno bipolar vem tendo avanços consistentes nos últimos anos. Um enfoque na relação entre carga alostática e alterações sistêmicas vem tomando corpo, com o objetivo de se entender a frequente progressão da doença. Proeminentes entre os mediadores periféricos têm sido as moléculas que poderiam ser amplamente agrupadas em neurotrofinas, marcadores de estresse oxidativo e marcadores inflamatórios. OBJETIVO: Descrever achados recentes em relaç...

  13. Carga eletrônica ativa trifásica

    OpenAIRE

    Heerdt, Joselito Anastácio

    2013-01-01

    Tese (doutorado) - Universidade Federal de Santa Catarina, Centro Tecnológico, Programa de Pós-Graduação em Engenharia Elétrica, Florianópolis, 2013. Neste trabalho estão apresentados os estudos efetuados do conversor trifásico bidirecional de três níveis (NPCm), aplicado a operação como Carga Eletrônica Ativa de corrente alternada. Os esforços de corrente e de tensão são analisados, modelados e comparados com o conversor NPC, bem como as perdas dos seus dispositivos semicondutores, para v...

  14. Carga inmediata en implantes dentales Immediate loading of dental implants

    Directory of Open Access Journals (Sweden)

    C. Concejo Cútoli

    2005-10-01

    Full Text Available El protocolo de carga convencional en una o dos fases quirúrgicas ha sido evaluado durante los últimos 30 años bajo todas las condiciones clínicas posibles. En comparación, la carga inmediata es un protocolo relativamente nuevo que necesita de una estricta evaluación clínica. Realizamos una búsqueda bibliográfica sobre los ensayos clínicos publicados de carga inmediata en función de las diferentes opciones terapéuticas que se pueden plantear. Se hallaron resultados comparables para las dos estrategias de carga en mandíbulas edéntulas. Para el tratamiento con prótesis inmediata de maxilares totalmente edéntulos, restauraciones parciales e unitarias es todavía necesaria una selección adecuada de pacientes y un diseño conservador de la prótesis provisional. La necesidad de ensayos clínicos sencillos aleatorizados de doble ciego, con suficiente número de pacientes y adecuado seguimiento, que comparen una determinada situación clínica con un patrón oclusal de la prótesis provisional bien definido, son imprescindibles para acabar de confirmar la seguridad de la técnica.The protocol for conventional loading in one or two surgical stages has been evaluated over the last 30 years under all the possible clinical conditions. By comparison, immediate loading is a relatively new protocol that requires strict clinical evaluation. We conducted a search of the literature published concerning clinical trials on immediate loading according to the different therapeutic options that could be considered. Comparable results were found for both loading strategies in edentulous mandibles. For treatment involving an immediate prosthesis for totally edentulous mandibles, partial and single tooth restorations, patients have to be selected adequately and provisional prostheses have to be designed conservatively. In order to completely confirm the safety of the technique, double-blind, simple, randomized clinical trials have to be carried out with

  15. Novel multiple criteria decision making methods based on bipolar neu trosophic sets and bipolar neutrosophic graphs

    OpenAIRE

    Muhammad Akram; Musavarah Sarwar

    2017-01-01

    In this research article, we present certain notions of bipolar neutrosophic graphs. We study the dominating and independent sets of bipolar neutrosophic graphs. We describe novel multiple criteria decision making methods based on bipolar neutrosophic sets and bipolar neutrosophic graphs.

  16. Discrete bipolar universal integrals

    Czech Academy of Sciences Publication Activity Database

    Greco, S.; Mesiar, Radko; Rindone, F.

    2014-01-01

    Roč. 252, č. 1 (2014), s. 55-65 ISSN 0165-0114 R&D Projects: GA ČR GAP402/11/0378 Institutional support: RVO:67985556 Keywords : bipolar integral * universal integral * Choquet integral Subject RIV: BA - General Mathematics Impact factor: 1.986, year: 2014 http://library.utia.cas.cz/separaty/2014/E/mesiar-0432224.pdf

  17. [Spouses and bipolar disorder].

    Science.gov (United States)

    Ellouze, F; Ayedi, S; Cherif, W; Ben Abla, T; M'rad, M F

    2011-02-01

    To assess the quality of life of a population of spouses of bipolar patients compared with a control population. We conducted a cross-sectional study which included two groups: a group of 30 spouses of patients followed for bipolar I disorder according to DSM IV criteria and a second group of 30 subjects from the general population. Both groups were matched by age, sex, marital status and socioeconomic level. This device was designed to limit the differences between the two groups solely those of the bipolar illness. Evaluating the quality of life was achieved using the quality of life scale: SF-36. This is a scale that has already been translated and validated in dialect Arabic. Regarding sociodemographic variables, the two study groups differed only for: recreation, friendly relations and the couple relationship that included more and better skills among the control group. In the categorical approach, the quality of life was impaired in 60% of spouses and 40% of controls with a statistically significant difference. The following standardized dimensions: mental health (D4), limitation due to mental health (D5), life and relationship with others (D6) and perceived health (D8) and mental component (CM) were significantly altered in patients' spouses compared to controls. We found significant differences between the two groups for: overall average score (51.1 vs. 68.2), mental health (D4), limitation due to mental health (D5), life and relationship with others (D6), perceived health (D8) and perceived health (D8) standards. The impairment of quality of life of bipolar patients' spouses is related to the extra responsibility, stress, financial problems and health problems, stigma, and loss of security of the person loved. Considering the consequences that the appearance of bipolar disorder on the patient's spouse may have, certain measures must be proposed to improve their quality of life. Copyright © 2010 L'Encéphale, Paris. Published by Elsevier Masson SAS. All

  18. ON BIPOLAR SINGLE VALUED NEUTROSOPHIC GRAPHS

    OpenAIRE

    Broumi, Said; Talea, Mohamed; Bakali, Assia; Smarandache, Florentin

    2016-01-01

    In this article, we combine the concept of bipolar neutrosophic set and graph theory. We introduce the notions of bipolar single valued neutrosophic graphs, strong bipolar single valued neutrosophic graphs, complete bipolar single valued neutrosophic graphs, regular bipolar single valued neutrosophic graphs and investigate some of their related properties.

  19. Early Intervention in Bipolar Disorder.

    Science.gov (United States)

    Vieta, Eduard; Salagre, Estela; Grande, Iria; Carvalho, André F; Fernandes, Brisa S; Berk, Michael; Birmaher, Boris; Tohen, Mauricio; Suppes, Trisha

    2018-01-24

    Bipolar disorder is a recurrent disorder that affects more than 1% of the world population and usually has its onset during youth. Its chronic course is associated with high rates of morbidity and mortality, making bipolar disorder one of the main causes of disability among young and working-age people. The implementation of early intervention strategies may help to change the outcome of the illness and avert potentially irreversible harm to patients with bipolar disorder, as early phases may be more responsive to treatment and may need less aggressive therapies. Early intervention in bipolar disorder is gaining momentum. Current evidence emerging from longitudinal studies indicates that parental early-onset bipolar disorder is the most consistent risk factor for bipolar disorder. Longitudinal studies also indicate that a full-blown manic episode is often preceded by a variety of prodromal symptoms, particularly subsyndromal manic symptoms, therefore supporting the existence of an at-risk state in bipolar disorder that could be targeted through early intervention. There are also identifiable risk factors that influence the course of bipolar disorder, some of them potentially modifiable. Valid biomarkers or diagnosis tools to help clinicians identify individuals at high risk of conversion to bipolar disorder are still lacking, although there are some promising early results. Pending more solid evidence on the best treatment strategy in early phases of bipolar disorder, physicians should carefully weigh the risks and benefits of each intervention. Further studies will provide the evidence needed to finish shaping the concept of early intervention.

  20. La carga global del cáncer (The Global Cancer Burden)

    Centers for Disease Control (CDC) Podcasts

    2012-02-02

    Este podcast describe la carga global del cáncer y los esfuerzos de los CDC y otras entidades para reducir esa carga.  Created: 2/2/2012 by National Center for Chronic Disease Prevention and Health Promotion (NCCDPHP).   Date Released: 3/13/2012.

  1. Tributación del Sector Transporte de Carga en Uruguay

    OpenAIRE

    Pedro Buonomo

    2004-01-01

    El objetivo general de este estudio es determinar la carga tributaria efectiva que incide sobre el transporte de cargas, en particular para los modos transporte terrestre (camión) y transporte aéreo, en la República Oriental del Uruguay.

  2. Life expectancy in bipolar disorder

    DEFF Research Database (Denmark)

    Kessing, Lars Vedel; Vradi, Eleni; Andersen, Per Kragh

    2015-01-01

    OBJECTIVE: Life expectancy in patients with bipolar disorder has been reported to be decreased by 11 to 20 years. These calculations are based on data for individuals at the age of 15 years. However, this may be misleading for patients with bipolar disorder in general as most patients have a later...... onset of illness. The aim of the present study was to calculate the remaining life expectancy for patients of different ages with a diagnosis of bipolar disorder. METHODS: Using nationwide registers of all inpatient and outpatient contacts to all psychiatric hospitals in Denmark from 1970 to 2012 we...... remaining life expectancy in bipolar disorder and that of the general population decreased with age, indicating that patients with bipolar disorder start losing life-years during early and mid-adulthood. CONCLUSIONS: Life expectancy in bipolar disorder is decreased substantially, but less so than previously...

  3. Bipolar Disorder and Alcoholism: Are They Related?

    Science.gov (United States)

    ... Is there a connection between bipolar disorder and alcoholism? Answers from Daniel K. Hall-Flavin, M.D. Bipolar disorder and alcoholism often occur together. Although the association between bipolar ...

  4. Afrontamiento y carga subjetiva en cuidadores primarios de adultos mayores dependientes de Andalucía, España

    Directory of Open Access Journals (Sweden)

    Margarita Pérez-Cruz

    2017-08-01

    Conclusiones: El afrontamiento disfuncional se relaciona con una mayor carga subjetiva y el afrontamiento centrado en las emociones se relaciona con una menor carga subjetiva, con independencia de la carga objetiva, el género y el parentesco de la persona cuidadora.

  5. [Creativity and bipolar disorder].

    Science.gov (United States)

    Maçkalı, Zeynep; Gülöksüz, Sinan; Oral, Timuçin

    2014-01-01

    The relationship between creativity and bipolar disorder has been an intriguing topic since ancient times. Early studies focused on describing characteristics of creative people. From the last quarter of the twentieth century, researchers began to focus on the relationship between mood disorders and creativity. Initially, the studies were based on biographical texts and the obtained results indicated a relationship between these two concepts. The limitations of the retrospective studies led the researchers to develop systematic investigations into this area. The systematic studies that have focused on artistic creativity have examined both the prevalence of mood disorders and the creative process. In addition, a group of researchers addressed the relationship in terms of affective temperaments. Through the end of the 90's, the scope of creativity was widened and the notion of everyday creativity was proposed. The emergence of this notion led researchers to investigate the associations of the creative process in ordinary (non-artist) individuals. In this review, the descriptions of creativity and creative process are mentioned. Also, the creative process is addressed with regards to bipolar disorder. Then, the relationship between creativity and bipolar disorder are evaluated in terms of aforementioned studies (biographical, systematic, psychobiographical, affective temperaments). In addition, a new model, the "Shared Vulnerability Model" which was developed to explain the relationship between creativity and psychopathology is introduced. Finally, the methodological limitations and the suggestions for resolving these limitations are included.

  6. Bipolar Disorder and Diabetes Mellitus

    Directory of Open Access Journals (Sweden)

    Sermin Kesebir

    2010-04-01

    Full Text Available Comorbid endocrine and cardiovascular situations with bipolar disorder usually result from the bipolar disorder itself or as a consequence of its treatment. With habits and lifestyle, genetic tendency and side effects, this situation is becoming more striking. Subpopulations of bipolar disorders patients should be considered at high risk for diabetes mellitus. The prevalence of diabetes mellitus in bipolar disorder may be three times greater than in the general population. Comorbidity of diabetes causes a pathophysiological overlapping in the neurobiological webs of bipolar cases. Signal mechanisms of glycocorticoid/insulin and immunoinflammatory effector systems are junction points that point out the pathophysiology between bipolar disorder and general medical cases susceptible to stress. Glycogen synthetase kinase (GSK-3 is a serine/treonine kinase and inhibits the transport of glucose stimulated by insulin. It is affected in diabetes, cancer, inflammation, Alzheimer disease and bipolar disorder. Hypoglycemic effect of lithium occurs via inhibiting glycogen synthetase kinase. When comorbid with diabetes, the other disease -for example bipolar disorder, especially during its acute manic episodes-, causes a serious situation that presents its influences for a lifetime. Choosing pharmacological treatment and treatment adherence are another important interrelated areas. The aim of this article is to discuss and review the etiological, clinical and therapeutic properties of diabetes mellitus and bipolar disorder comorbidity.

  7. Cargas de trabalho encontrada nos coletores de lixo domiciliar

    OpenAIRE

    Madruga, Rosângela Batista

    2002-01-01

    Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro Tecnológico. Programa de Pós-Graduação em Engenharia de Produção. O presente estudo de caso foi realizado em uma empresa de coleta de lixo da grande Florianópolis, com objetivo de analisar as cargas de trabalho dos coletores de lixo domiciliar. Foi utilizado o recurso metodológico da Análise Ergonômica do Trabalho, cujo enfoque se deu através da Análise da Atividade e das condições de realização do trabalho, com propós...

  8. Medios auxiliares para la carga de traíllas

    Directory of Open Access Journals (Sweden)

    Chinchilla, M.

    1963-06-01

    Full Text Available The large difference in the power that is necessary to load the scraper and to transport the material has an important influence on the economic efficiency involved in transporting soil with this type of equipment. This problem has made it necessary to develop various kinds of machinery fitted with less powerful engines, and hence, having a smaller fuel consumption and of lower initial cost. Among the systems normally adopted to help the loading operation the following may be cited: auxiliary pushing tractors; mutual aid by several scrapers; and machinery fitted with mechanical means to avoid material from penetrating into other material that is already loaded. The use of auxiliary pushing tractors requires many additional services, and also a greater capital outlay in equipment. The scrapers fitted with a mechanical system for lifting the load need a much smaller drawing power to carry out this operation, and consequently the mean available and mean required power during the operating cycle is more advantageous than in ordinary scrapers. Even so, the utilisation of these new type scrapers is also subjected to various limiting circumstances which prevent this from being the best possible solution for this type of work. In spite of the increasing use of vibratory techniques, so far vibration has not yet become a generalised procedure in loading of scrapers, no doubt due to the large volumen and mass of material involved in the procedure.La disparidad entre las potencias necesarias para efectuar la carga de las traíllas y la utilizable en el transporte del material influyen poderosamente en el rendimiento económico del transporte de tierras mediante este tipo de maquinaria. Esto ha exigido el estudiar y desarrollar diversos sistemas que permitan el empleo de máquinas dotadas de motores de menor potencia y, consiguientemente, de menor consumo y coste inicial. Entre los sistemas comúnmente empleados para facilitar las operaciones de carga

  9. Capacidade de Carga em Cidades Históricas

    Directory of Open Access Journals (Sweden)

    Fernando Vicente de Oliveira

    2010-08-01

    Full Text Available Neste artigo são apresentados os conceitos de capacidade de carga e capacidade ambiental vinculando-os ao manejo de cidades históricas dentro dos pressupostos do turismo sustentável. A avaliação da capacidade ambiental é uma valiosa ferramenta para planejamento turístico. O principal é determinar até que ponto um meio ambiente pode suportar uma intervenção, sem que a mesma danifique ou prejudique a característica principal deste local. As cidades históricas e turísticas com desejo de fomentar o turismo devem, necessariamente, delimitar suas capacidades de crescimento, para geração de riquezas através de sua economia diversificada e, sobretudo, bem estar de sua população, principal objetivo do estudo de capacidade ambiental.

  10. Construção de gênero, laços afetivos e luto em Paris Is Burning

    Directory of Open Access Journals (Sweden)

    Raquel Parrine

    2017-10-01

    Full Text Available O filme Paris Is Burning, de Jennie Livingston, tem suscitado críticas e elogios desde seu lançamento, em 1990. Seu retrato da cultura dos bailes no Harlem nos anos 80, a abordagem da sua singular economia de construção de gênero e as negociações que faz do cruzamento entre etnicidade e sexualidade inspiraram leituras desde o ativismo negro, o pós-estruturalismo e, mais recentemente, os estudos trans. Mas, além da questão da problematização da apropriação e da autoria, existem camadas do documentário que nos levam a refletir a respeito da construção de laços afetivos, de comunidade e da autonomia da agência de sujeitos marginalizados e sua resiliência em face da violência de gênero. Apesar da espetacularização oriunda dos bailes, o filme comunica dignidade de seus sujeitos e opera no espectador a experiência do luto, que propõe uma comunidade compartilhada que finalmente nos una apartir da diferença.

  11. Algumas reflexões sobre relacionamentos afetivos e relações sexuais na adolescência

    Directory of Open Access Journals (Sweden)

    Elaine Italiano Vidal

    2008-12-01

    Full Text Available Sexo e sexualidade são temas bastante abordados pela sociedade e suas instituições, desde a mídia até a universidade. Também a escola de ensino fundamental e médio vem sendo apontada como espaço propício para se trabalhar com orientação sexual, considerando inclusive as questões em voga como a gravidez não planejada na adolescência, as relações de gênero, o combate à homofobia e as doenças sexualmente transmissíveis, particularmente a AIDS. O presente trabalho é resultado de uma pesquisa realizada com adolescentes de 14 a 19 anos, estudantes de uma escola pública de ensino médio, tendo como objetivos verificar como pensam e se comportam os jovens frente a questões e atitudes que envolvem sexo e sexualidade. A técnica de coleta de dados foi a redação, em que os sujeitos escreveram sobre idéias, práticas e comportamentos sexuais, sendo que no recorte feito para a apresentação deste artigo, nos prendemos aos relacionamentos afetivos e relações sexuais.

  12. Violências percebidas por homens adolescentes na interação afetivo-sexual em dez cidades brasileiras

    Directory of Open Access Journals (Sweden)

    Fátima Cecchetto

    2016-01-01

    Full Text Available O presente artigo apresenta as visões de adolescentes do sexo masculino sobre o tema da violência no namoro. A partir de entrevistas e grupos focais realizados em dez cidades brasileiras, entre 2007 e 2009, o texto toma como parâmetro a análise dos significados atribuídos pelos jovens às agressões físicas, psicológicas e sexuais no âmbito dos relacionamentos íntimos. A metodologia do estudo se concentra nos depoimentos de 257 estudantes do sexo masculino, de idades entre 15 e 19 anos, de escolas públicas e privadas do país. Os resultados do estudo mostram que os significados atribuídos ao fenômeno da violência no namoro são recortados por representações rígidas de papéis de gênero, correspondendo às expectativas em relação ao desempenho de homens e mulheres nas relações afetivo-sexuais.

  13. Análise de cargas acidentais em pavimentos de garagem

    Directory of Open Access Journals (Sweden)

    D. A. Tenório

    Full Text Available O trabalho tem como foco a análise das cargas acidentais utilizadas para pavimentos de garagem, considerando as recomendações de normas nacionais e internacionais para a definição do valor das cargas a serem aplicadas nas lajes nervuradas. A norma brasileira NBR 6120/1980 [1], que trata do assunto, não especifica nada em relação a cargas concentradas, enquanto normas internacionais como Euro Code [2] e IBC [3], recomendam considerar cargas distribuídas e concentradas. Atualmente, as lajes nervuradas são utilizadas amplamente em pavimentos de garagem. Neste contexto, considerando os padrões de veículos mais utilizados no país, será que os valores de cargas distribuídas das normas são adequados para o dimensionamento das lajes nervuradas? Ou é necessário fazer uma correção destas cargas para levar em consideração as cargas concentradas da ordem de 8,5 kN por pneu correspondente a um veículo utilitário. O objetivo deste trabalho é procurar as respostas para estas duas perguntas através de uma análise paramétrica envolvendo os principais parâmetros de uma laje nervurada, que são: a relação (lambda entre os lados, a distância entre as nervuras principais e o esquema de apoio da laje (uni ou bidirecional. De uma forma geral o conjunto das simulações mostra que as cargas recomendadas pelas normas citadas precisariam de correção quando utilizadas em pavimento de garagem para reproduzir o efeito das cargas concentradas das rodas de veículos tipo utilitário.

  14. The impact of bipolar depression.

    Science.gov (United States)

    Post, Robert M

    2005-01-01

    Bipolar disorder is a chronic, intermittent illness that is associated with high morbidity and mortality. In addition, patients with bipolar disorder often have comorbid psychiatric conditions (such as anxiety disorders, alcohol or substance abuse, and eating disorders) or medical disorders (such as obesity), which result in increased burden of illness for the patients, family members, and treating clinicians. Although bipolar disorder consists of recurring episodes of mania and depression, patients spend more time depressed than manic. Bipolar depression is associated with a greater risk of suicide and of impairment in work, social, or family life than mania. This health burden also results in direct and indirect economic costs to the individual and society at large. Bipolar depression is often undiagnosed or misdiagnosed as unipolar depression, resulting in incorrect or inadequate treatment. Available treatments for bipolar depression include medications such as lithium, selected anticonvulsants, and the atypical antipsychotics. Traditional antidepressants are not recommended as monotherapy for bipolar depression as they can induce switching to mania. Early and accurate diagnosis, aggressive management, and earlier prophylactic treatment regimens are needed to overcome the impact of depressive episodes in patients with bipolar disorder.

  15. Diseño y desarrollo de un elevador industrial de carga para la empresa CODIMEC

    OpenAIRE

    García Sierra, Catalina María; Uribe Aguirre, Alejandro

    2006-01-01

    Este proyecto pretende entregar el diseño de una estructura que permita crear diferentes configuraciones de elevadores de carga para diferentes aplicaciones, creando así la línea de elevadores que requiere la empresa CODIMEC LTDA, empresa antioqueña qua ha venido incursionando hace unos años en la construcción de elevadores de carga. Además el proyecto creó un catálogo de elevadores de carga, por medio del cual la empresa puede ofrecer los elevadores.

  16. Evaluaci?n de las condiciones de trabajo: carga postural: M?todo REBA

    OpenAIRE

    Nogareda Cuixart, Silvia

    2003-01-01

    En la introducci?n se resalta la importancia del m?todo en el sentido que enfoca la valoraci?n de la carga postural en casos en que se ha de manipular cargas animadas y su similitud en algunos aspectos con el m?todo RULA. Luego se definen los objetivos de la metodolog?a y se inicia con la explicaci?n de la aplicaci?n del m?todo con la valoraci?n y puntuaci?n de la postura en los distintos segmentos corporales. Finalmente se muestran las tablas para puntuaci?n de carga/fuerza, agarre, activida...

  17. Desarrollo de una Escala Subjetiva de Carga Mental de Trabajo (ESCAM)

    OpenAIRE

    Gladys Rolo González; Dolores Díaz Cabrera; Estefanía Hernández Fernaud

    2009-01-01

    El objetivo de este estudio fue analizar las características psicométricas de un instrumento multidimensional de la carga mental subjetiva (ESCAM). La muestra estuvo constituida por 474 participantes. Se elaboró una escala de carga mental compuesto por 31 ítems. Mediante un análisis factorial se obtuvieron cinco dimensiones de carga mental: demandas cognitivas y complejidad de la información, consecuencias para la salud, características de las tareas, organización temporal y ritmo de trabajo....

  18. Scientific attitudes towards bipolar disorders

    Directory of Open Access Journals (Sweden)

    Mohammad-Hossein Biglu

    2014-02-01

    Full Text Available Introduction: Bipolar disorder is a psychiatric condition that is also called manic-depressive disease. It causes unusual changes in mood, energy, activity levels, and the ability to carry out day-to-day tasks. In the present study, 3 sets of data were considered and analyzed: first, all papers categorized under Bipolar Disorders in Science Citation Index Expanded (SCI-E database through 2001-2011; second, papers published by the international journal of Bipolar Disorders indexed in SCI-E during a period of 11 years; and third, all papers distributed by the international journal of Bipolar Disorders indexed in MEDLINE during the period of study. Methods: The SCI-E database was used to extract all papers indexed with the topic of Bipolar Disorders as well as all papers published by The International Journal of Bipolar Disorders. Extraction of data from MEDLINE was restricted to the journals name from setting menu. The Science of Science Tool was used to map the co-authorship network of papers published by The International Journal of Bipolar Disorders through 2009-2011. Results: Analysis of data showed that the majority of publications in the subject area of bipolar disorders indexed in SCI-E were published by The International Journal of Bipolar Disorders. Although journal articles consisted of 59% of the total publication type in SCI-E, 65% of publications distributed by The Journal of Bipolar Disorders were in the form of meetingabstracts. Journal articles consisted of only 23% of the total publications. USA was the leading country regarding sharing data in the field of bipolar disorders followed by England, Canada, and Germany. Conclusion: The editorial policy of The International Journal of Bipolar Disorders has been focused on new themes and new ways of researching in the subject area of bipolar disorder. Regarding the selection of papers for indexing, the SCI-E database selects data more comprehensively than MEDLINE. The number of papers

  19. Genetics of bipolar disorder

    Directory of Open Access Journals (Sweden)

    Kerner B

    2014-02-01

    Full Text Available Berit Kerner Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA Abstract: Bipolar disorder is a common, complex genetic disorder, but the mode of transmission remains to be discovered. Many researchers assume that common genomic variants carry some risk for manifesting the disease. The research community has celebrated the first genome-wide significant associations between common single nucleotide polymorphisms (SNPs and bipolar disorder. Currently, attempts are under way to translate these findings into clinical practice, genetic counseling, and predictive testing. However, some experts remain cautious. After all, common variants explain only a very small percentage of the genetic risk, and functional consequences of the discovered SNPs are inconclusive. Furthermore, the associated SNPs are not disease specific, and the majority of individuals with a “risk” allele are healthy. On the other hand, population-based genome-wide studies in psychiatric disorders have rediscovered rare structural variants and mutations in genes, which were previously known to cause genetic syndromes and monogenic Mendelian disorders. In many Mendelian syndromes, psychiatric symptoms are prevalent. Although these conditions do not fit the classic description of any specific psychiatric disorder, they often show nonspecific psychiatric symptoms that cross diagnostic boundaries, including intellectual disability, behavioral abnormalities, mood disorders, anxiety disorders, attention deficit, impulse control deficit, and psychosis. Although testing for chromosomal disorders and monogenic Mendelian disorders is well established, testing for common variants is still controversial. The standard concept of genetic testing includes at least three broad criteria that need to be fulfilled before new genetic tests should be introduced: analytical validity, clinical validity, and clinical utility. These criteria are

  20. Novel multiple criteria decision making methods based on bipolar neutrosophic sets and bipolar neutrosophic graphs

    OpenAIRE

    Muhammad, Akram; Musavarah, Sarwar

    2016-01-01

    In this research study, we introduce the concept of bipolar neutrosophic graphs. We present the dominating and independent sets of bipolar neutrosophic graphs. We describe novel multiple criteria decision making methods based on bipolar neutrosophic sets and bipolar neutrosophic graphs. We also develop an algorithm for computing domination in bipolar neutrosophic graphs.

  1. Bipolar pulse forming line

    Science.gov (United States)

    Rhodes, Mark A.

    2008-10-21

    A bipolar pulse forming transmission line module for linear induction accelerators having first, second, third, fourth, and fifth planar conductors which form an interleaved stack with dielectric layers between the conductors. Each conductor has a first end, and a second end adjacent an acceleration axis. The first and second planar conductors are connected to each other at the second ends, the fourth and fifth planar conductors are connected to each other at the second ends, and the first and fifth planar conductors are connected to each other at the first ends via a shorting plate adjacent the first ends. The third planar conductor is electrically connectable to a high voltage source, and an internal switch functions to short a high voltage from the first end of the third planar conductor to the first end of the fourth planar conductor to produce a bipolar pulse at the acceleration axis with a zero net time integral. Improved access to the switch is enabled by an aperture through the shorting plate and the proximity of the aperture to the switch.

  2. Desarrollo de una Escala Subjetiva de Carga Mental de Trabajo (ESCAM

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    Gladys Rolo González

    2009-01-01

    Full Text Available El objetivo de este estudio fue analizar las características psicométricas de un instrumento multidimensional de la carga mental subjetiva (ESCAM. La muestra estuvo constituida por 474 participantes. Se elaboró una escala de carga mental compuesto por 31 ítems. Mediante un análisis factorial se obtuvieron cinco dimensiones de carga mental: demandas cognitivas y complejidad de la información, consecuencias para la salud, características de las tareas, organización temporal y ritmo de trabajo. Los resultados mostraron la consistencia interna para cada dimensión de carga mental así como la fiabilidad de la escala.

  3. Autonomia do cuidado: interlocução afetivo-sexual com adolescentes no PET-Saúde

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    Tiago Soares Baumfeld

    Full Text Available Realizou-se, dentro do Programa de Educação pelo Trabalho para a Saúde (PET-Saúde, uma pesquisa-ação em conjunto com o Centro de Saúde e a Escola Municipal de Glaura, um dos distritos de Ouro Preto/MG, reunindo 123 alunos, entre 11 e 19 anos de idade, que participaram de encontros semanais de abril de 2009 a março de 2010. O projeto visava à integração entre ensino e serviço de saúde, ao desenvolvimento da autonomia do cuidado, à construção de vínculos e ao intercâmbio de conhecimento com os adolescentes. Pautou-se na horizontalidade das relações entre os monitores, o preceptor, a tutora e os adolescentes, sob a óptica da visão freiriana de educação popular. Foram realizadas dinâmicas, encenações cômicas e quizzes, tendo a sexualidade como tema principal. Posteriormente, estimulou-se a confecção de ferramentas multiplicadoras pelos adolescentes, como vídeos e peças de teatro, tornando-os protagonistas do processo de ensino-aprendizagem. Este artigo serve como parâmetro para avaliação qualitativa da eficácia do PET-Saúde, além de discutir a relevância do programa para a formação médica, especialmente no que tange as habilidades dos profissionais de saúde para fornecer orientação afetivo-sexual aos adolescentes.

  4. Asenapine for bipolar disorder

    Directory of Open Access Journals (Sweden)

    Scheidemantel T

    2015-12-01

    Full Text Available Thomas Scheidemantel,1 Irina Korobkova,2 Soham Rej,3,4 Martha Sajatovic1,2 1University Hospitals Case Medical Center, 2Case Western Reserve University School of Medicine, Cleveland, OH, USA; 3Department of Psychiatry, University of Toronto, Toronto, ON, 4Geri PARTy Research Group, Jewish General Hospital, Montreal, QC, Canada Abstract: Asenapine (Saphris® is an atypical antipsychotic drug which has been approved by the US Food and Drug Administration for the treatment of schizophrenia in adults, as well as the treatment of acute manic or mixed episodes of bipolar I in both adult and pediatric populations. Asenapine is a tetracyclic drug with antidopaminergic and antiserotonergic activity with a unique sublingual route of administration. In this review, we examine and summarize the available literature on the safety, efficacy, and tolerability of asenapine in the treatment of bipolar disorder (BD. Data from randomized, double-blind trials comparing asenapine to placebo or olanzapine in the treatment of acute manic or mixed episodes showed asenapine to be an effective monotherapy treatment in clinical settings; asenapine outperformed placebo and showed noninferior performance to olanzapine based on improvement in the Young Mania Rating Scale scores. There are limited data available on the use of asenapine in the treatment of depressive symptoms of BD, or in the maintenance phase of BD. The available data are inconclusive, suggesting the need for more robust data from prospective trials in these clinical domains. The most commonly reported adverse effect associated with use of asenapine is somnolence. However, the somnolence associated with asenapine use did not cause significant rates of discontinuation. While asenapine was associated with weight gain when compared to placebo, it appeared to be modest when compared to other atypical antipsychotics, and its propensity to cause increases in hemoglobin A1c or serum lipid levels appeared to be

  5. Ion bipolar junction transistors.

    Science.gov (United States)

    Tybrandt, Klas; Larsson, Karin C; Richter-Dahlfors, Agneta; Berggren, Magnus

    2010-06-01

    Dynamic control of chemical microenvironments is essential for continued development in numerous fields of life sciences. Such control could be achieved with active chemical circuits for delivery of ions and biomolecules. As the basis for such circuitry, we report a solid-state ion bipolar junction transistor (IBJT) based on conducting polymers and thin films of anion- and cation-selective membranes. The IBJT is the ionic analogue to the conventional semiconductor BJT and is manufactured using standard microfabrication techniques. Transistor characteristics along with a model describing the principle of operation, in which an anionic base current amplifies a cationic collector current, are presented. By employing the IBJT as a bioelectronic circuit element for delivery of the neurotransmitter acetylcholine, its efficacy in modulating neuronal cell signaling is demonstrated.

  6. Indirect bipolar electrodeposition.

    Science.gov (United States)

    Loget, Gabriel; Roche, Jérome; Gianessi, Eugenio; Bouffier, Laurent; Kuhn, Alexander

    2012-12-12

    Based on the principles of bipolar electrochemistry, localized pH gradients are generated at the surface of conducting particles in solution. This allows the toposelective deposition of inorganic and organic polymer layers via a pH-triggered precipitation mechanism. Due to the intrinsic symmetry breaking of the process, the concept can be used to generate in a straightforward way Janus particles, with one section consisting of deposits obtained from non-electroactive precursors. These indirect electrodeposits, such as SiO(2), TiO(2), or electrophoretic paints, can be further used as an immobilization matrix for other species like dyes or nanoparticles, thus opening promising perspectives for the synthesis of a variety of bifunctional objects with a controlled shape.

  7. Facial emotion recognition in bipolar disorder: a critical review Reconhecimento de emoções faciais: artigo de revisão

    Directory of Open Access Journals (Sweden)

    Cristiana Castanho de Almeida Rocca

    2009-06-01

    : Bipolares eutímicos apresentaram prejuízo no reconhecimento de nojo e medo. Em mania, mostraram dificuldade para reconhecer medo e tristeza. Transtorno bipolar pediátrico e crianças de risco apresentam dificuldade para reconhecer emoções nos rostos de adultos e de crianças. Bipolares foram mais precisos para reconhecer emoções do que os pacientes esquizofrênicos. DISCUSSÃO: Pacientes com transtorno bipolar apresentam prejuízo no reconhecimento de nojo, medo e tristeza, os quais podem ser apenas em parte atribuídos ao estado de humor. No episódio maníaco, eles têm dificuldade para reconhecer medo e nojo. Entretanto, eles são mais precisos no reconhecimento de emoções do que pacientes deprimidos e esquizofrênicos. Crianças com transtorno bipolar apresentam tendência a julgar expressões faciais extremas como sendo de intensidade leve ou moderada. CONCLUSÃO: Déficits afetivos e cognitivos em bipolares sofrem variações dependendo do estado de humor. Estudos de seguimento, reavaliando pacientes após a remissão dos sintomas, são necessários para investigar se estas anormalidades refletem um estado ou traço da doença e se podem ser consideradas endofenótipos. Estudos futuros devem padronizar tarefas e metodologia.

  8. Genetics of bipolar disorder.

    Science.gov (United States)

    Kerner, Berit

    2014-01-01

    Bipolar disorder is a common, complex genetic disorder, but the mode of transmission remains to be discovered. Many researchers assume that common genomic variants carry some risk for manifesting the disease. The research community has celebrated the first genome-wide significant associations between common single nucleotide polymorphisms (SNPs) and bipolar disorder. Currently, attempts are under way to translate these findings into clinical practice, genetic counseling, and predictive testing. However, some experts remain cautious. After all, common variants explain only a very small percentage of the genetic risk, and functional consequences of the discovered SNPs are inconclusive. Furthermore, the associated SNPs are not disease specific, and the majority of individuals with a "risk" allele are healthy. On the other hand, population-based genome-wide studies in psychiatric disorders have rediscovered rare structural variants and mutations in genes, which were previously known to cause genetic syndromes and monogenic Mendelian disorders. In many Mendelian syndromes, psychiatric symptoms are prevalent. Although these conditions do not fit the classic description of any specific psychiatric disorder, they often show nonspecific psychiatric symptoms that cross diagnostic boundaries, including intellectual disability, behavioral abnormalities, mood disorders, anxiety disorders, attention deficit, impulse control deficit, and psychosis. Although testing for chromosomal disorders and monogenic Mendelian disorders is well established, testing for common variants is still controversial. The standard concept of genetic testing includes at least three broad criteria that need to be fulfilled before new genetic tests should be introduced: analytical validity, clinical validity, and clinical utility. These criteria are currently not fulfilled for common genomic variants in psychiatric disorders. Further work is clearly needed before genetic testing for common variants in

  9. Modeling suicide in bipolar disorders.

    Science.gov (United States)

    Malhi, Gin S; Outhred, Tim; Das, Pritha; Morris, Grace; Hamilton, Amber; Mannie, Zola

    2018-02-19

    Suicide is a multicausal human behavior, with devastating and immensely distressing consequences. Its prevalence is estimated to be 20-30 times greater in patients with bipolar disorders than in the general population. The burden of suicide and its high prevalence in bipolar disorders make it imperative that our current understanding be improved to facilitate prediction of suicide and its prevention. In this review, we provide a new perspective on the process of suicide in bipolar disorder, in the form of a novel integrated model that is derived from extant knowledge and recent evidence. A literature search of articles on suicide in bipolar disorder was conducted in recognized databases such as Scopus, PubMed, and PsycINFO using the keywords "suicide", "suicide in bipolar disorders", "suicide process", "suicide risk", "neurobiology of suicide" and "suicide models". Bibliographies of identified articles were further scrutinized for papers and book chapters of relevance. Risk factors for suicide in bipolar disorders are well described, and provide a basis for a framework of epigenetic mechanisms, moderated by neurobiological substrates, neurocognitive functioning, and social inferences within the environment. Relevant models and theories include the diathesis-stress model, the bipolar model of suicide and the ideation-to-action models, the interpersonal theory of suicide, the integrated motivational-volitional model, and the three-step theory. Together, these models provide a basis for the generation of an integrated model that illuminates the suicidal process, from ideation to action. Suicide is complex, and it is evident that a multidimensional and integrated approach is required to reduce its prevalence. The proposed model exposes and provides access to components of the suicide process that are potentially measurable and may serve as novel and specific therapeutic targets for interventions in the context of bipolar disorder. Thus, this model is useful not only

  10. Quetiapine monotherapy for bipolar depression

    Directory of Open Access Journals (Sweden)

    Michael E Thase

    2008-03-01

    Full Text Available Michael E ThaseDepartments of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA, USA; the Philadelphia Veterans Affairs Medical Center, Philadelphia, PA, USA; and the University of Pittsburgh Medical Center, Pittsburgh, PA, USAAbstract: Bipolar depression is more common, disabling, and difficult-to-treat than the manic and hypomanic phases that define bipolar disorder. Unlike the treatment of so-called “unipolar” depressions, antidepressants generally are not indicated as monotherapies for bipolar depressions and recent studies suggest that - even when used in combination with traditional mood stabilizers – antidepressants may have questionable value for bipolar depression. The current practice is that mood stabilizers are initiated first as monotherapies; however, the antidepressant efficacy of lithium and valproate is modest at best. Within this context the role of atypical antipsychotics is being evaluated. The combination of olanzapine and the antidepressant fluoxetine was the first treatment to receive regulatory approval in the US specifically for bipolar I depression. Quetiapine was the second medication to be approved for this indication, largely as the result of two pivotal trials known by the acronyms of BOLDER (BipOLar DEpRession I and II. Both studies demonstrated that two doses of quetiapine (300 mg and 600 mg given once daily at bedtime were significantly more effective than placebo, with no increased risk of patients switching into mania. Pooling the two studies, quetiapine was effective for both bipolar I and bipolar II depressions and for patients with (and without a history of rapid cycling. The two doses were comparably effective in both studies. Although the efficacy of quetiapine monotherapy has been established, much additional research is necessary. Further studies are needed to more fully investigate dose-response relationships and comparing quetiapine monotherapy to other mood stabilizers

  11. Integrated neurobiology of bipolar disorder

    Directory of Open Access Journals (Sweden)

    Vladimir eMaletic

    2014-08-01

    Full Text Available From a neurobiological perspective there is no such thing as bipolar disorder. Rather, it is almost certainly the case that many somewhat similar, but subtly different, pathological conditions produce a disease state that we currently diagnose as bipolarity. This heterogeneity—reflected in the lack of synergy between our current diagnostic schema and our rapidly advancing scientific understanding of the condition—limits attempts to articulate an integrated perspective on bipolar disorder. However, despite these challenges, scientific findings in recent years are beginning to offer a provisional unified field theory of the disease. This theory sees bipolar disorder as a suite of related neurodevelopmental conditions with interconnected functional abnormalities that often appear early in life and worsen over time. In addition to accelerated loss of volume in brain areas known to be essential for mood regulation and cognitive function, consistent findings have emerged at a cellular level, providing evidence that bipolar disorder is reliably associated with dysregulation of glial-neuronal interactions. Among these glial elements are microglia—the brain’s primary immune elements, which appear to be overactive in the context of bipolarity. Multiple studies now indicate that inflammation is also increased in the periphery of the body in both the depressive and manic phases of the illness, with at least some return to normality in the euthymic state. These findings are consistent with changes in the HPA axis, which are known to drive inflammatory activation. In summary, the very fact that no single gene, pathway or brain abnormality is likely to ever account for the condition is itself an extremely important first step in better articulating an integrated perspective on both its ontological status and pathogenesis. Whether this perspective will translate into the discovery of innumerable more homogeneous forms of bipolarity is one of the great

  12. [Genetics of bipolar disorder].

    Science.gov (United States)

    Budde, M; Forstner, A J; Adorjan, K; Schaupp, S K; Nöthen, M M; Schulze, T G

    2017-07-01

    Bipolar disorder (BD) has a multifactorial etiology. Its development is influenced by genetic as well as environmental factors. Large genome-wide association studies (GWAS), in which genetic risk allelic variants for the disorder could be replicated for the first time, marked the breakthrough in the identification of the responsible risk genes. In addition to these common genetic variants with moderate effects identified by GWAS, rare variants with a higher penetrance are expected to play a role in disease development. The results of recent studies suggest that copy number variants might contribute to BD development, although to a lesser extent than in other psychiatric disorders, such as schizophrenia or autism. Results from the initial next generation sequencing studies indicate an enrichment of rare variants in pathways and genes that were previously found to be associated with BD. In the field of pharmacogenetics, a risk gene that influences the individual variance in the response to lithium treatment was identified for the first time in a recent large international GWAS. Currently the reported risk alleles do not sufficiently explain the phenotypic variance to be used for individual prediction of disease risk, disease course or response to medication. Future genetic research will provide important insights into the biological basis of BD by the identification of additional genes associated with BD. This knowledge of genetics will help identify potential etiological subgroups as well as cross-diagnostic disease mechanisms.

  13. Bipolar Disorder in Children and Teens

    Science.gov (United States)

    ... I do? Share Bipolar Disorder in Children and Teens Download PDF Download ePub Order a free hardcopy ... Think about death or suicide Can children and teens with bipolar disorder have other problems? Young people ...

  14. Exercising control over bipolar disorder.

    Science.gov (United States)

    Malhi, Gin S; Byrow, Yulisha

    2016-11-01

    Following extensive research exercise has emerged as an effective treatment for major depressive disorder, and it is now a recognised therapy alongside other interventions. In contrast, there is a paucity of research examining the therapeutic effects of exercise for those with bipolar disorder. Given that dysfunctional reward processing is central to bipolar disorder, research suggests that exercise can perhaps be framed as a reward-related event that may have the potential to precipitate a manic episode. The behavioural activation system (BAS) is a neurobehavioural system that is associated with responding to reward and provides an appropriate framework to theoretically examine and better understand the effects of exercise treatment on bipolar disorder. This article discusses recent research findings and provides an overview of the extant literature related to the neurobiological underpinnings of BAS and exercise as they relate to bipolar disorder. This is important clinically because depending on mood state in bipolar disorder, we postulate that exercise could be either beneficial or deleterious with positive or negative effects on the illness. Clearly, this complicates the evaluation of exercise as a potential treatment in terms of identifying its optimal characteristics in this population. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  15. Teoría de la carga cognitiva, diseño multimedia y aprendizaje: un estado del arte (Cognitive Load Theory, Design and Multimedia Learning: A State of the Art (Théorie de la charge cognitive, dessin multimédia et apprentissage: un état de l′art (Teoria da carga cognitiva, desenho multimídia e aprendizagem: um estado da arte

    Directory of Open Access Journals (Sweden)

    Luis Alejandro Andrade Lotero

    2012-12-01

    'apprentissage.ResumoNeste artigo de revisão se apresenta um resumo da teoria da carga cog- nitiva e da teoria cognitiva da apren- dizagem multimídia. Apresentam-se alguns exemplos de pesquisas empí- ricas e se reflete a respeito do valor explicativo destas teorias da aprendi- zagem. São expostos dez princípios para o desenho de material instru- cional. Afirma-se também que outras pesquisas encontraram limitações no uso e prática destas teorias. Estas se referem principalmente à medição da carga cognitiva, à experiência e conhecimento prévio dos aprendizes, bem como à motivação e aspectos afetivos que intervêm no processo de aprendizagem.

  16. Imunologia do transtorno bipolar Immunology of bipolar disorder

    Directory of Open Access Journals (Sweden)

    Izabela Guimarães Barbosa

    2009-01-01

    Full Text Available OBJETIVO: Pesquisas recentes têm implicado fatores imunes na patogênese de diversos transtornos neuropsiquiátricos. O objetivo do presente trabalho é revisar os trabalhos que investigaram a associação entre transtorno bipolar e alterações em parâmetros imunes. MÉTODOS: Artigos que incluíam as palavras-chave: "bipolar disorder", "mania", "immunology", "cytokines", "chemokines", "interleukins", "interferon" e "tumor necrosis factor" foram selecionados em uma revisão sistemática da literatura. As bases de dados avaliadas foram MedLine e Scopus, entre os anos de 1980 e 2008. RESULTADOS: Foram identificados 28 trabalhos que estudaram alterações imunes em pacientes com transtorno bipolar. Seis artigos investigaram genes relacionados à resposta imune; cinco, autoanticorpos; quatro, populações leucocitárias; 13, citocinas e/ou moléculas relacionadas à resposta imune e seis, leucócitos de pacientes in vitro. CONCLUSÕES: Embora haja evidências na literatura correlacionando o transtorno bipolar a alterações imunes, os dados não são conclusivos. O transtorno bipolar parece estar associado a níveis mais elevados de autoanticorpos circulantes, assim como à tendência à ativação imune com produção de citocinas pró-inflamatórias e redução de parâmetros anti-inflamatórios.OBJECTIVE: Emerging research has implicated immune factors in the pathogenesis of a variety of neuropsychiatric disorders. The objective of the present paper is to review the studies that investigated the association between bipolar disorder and immune parameters. METHODS: Papers that included the keywords "bipolar to disorder", "mania", "immunology", "cytokines", "chemokines", "interleukins", "interferon" and "tumor necrosis factor" were selected in a systematic review of the literature. The evaluated databases were MedLine and Scopus in the period between 1980 and 2008. RESULTS: Twenty eight works were found. Six studies investigated immune response

  17. Mathematical models of bipolar disorder

    Science.gov (United States)

    Daugherty, Darryl; Roque-Urrea, Tairi; Urrea-Roque, John; Troyer, Jessica; Wirkus, Stephen; Porter, Mason A.

    2009-07-01

    We use limit cycle oscillators to model bipolar II disorder, which is characterized by alternating hypomanic and depressive episodes and afflicts about 1% of the United States adult population. We consider two non-linear oscillator models of a single bipolar patient. In both frameworks, we begin with an untreated individual and examine the mathematical effects and resulting biological consequences of treatment. We also briefly consider the dynamics of interacting bipolar II individuals using weakly-coupled, weakly-damped harmonic oscillators. We discuss how the proposed models can be used as a framework for refined models that incorporate additional biological data. We conclude with a discussion of possible generalizations of our work, as there are several biologically-motivated extensions that can be readily incorporated into the series of models presented here.

  18. Factores que afectan la carga electrostática en polvos cerámicos

    Directory of Open Access Journals (Sweden)

    Fernández, J. F.

    2011-04-01

    Full Text Available The phenomenon of electrostatic charge in ceramic powders takes place when the particle surfaces enter in contact between them or with the containers. The accumulation of electrostatic charge is of relevance in ceramic powders in view of their insulating character and the risk of explosions during the material handling. In this work the main factors that affect the appearance of intrinsic charge and tribo-charge in ceramic powder have been studied. In ceramic powders of alumina it has been verified that the smallest particle sizes present an increase of the electrostatic charge of negative polarity. A correlation has been observed between the nature of the OH -surface groups and the electrostatic charge. The intrinsic charge and the tribocharge in ceramic powders can be diminished by compensating the surface groups that support the charge. The dry dispersion of nanoparticles on microparticles allows surface charge compensation with a noticeable modification of the powder agglomeration.

    Los fenómenos de carga electroestática en polvos cerámicos se producen cuando las superficies de los mismos entran en contacto entre sí y con los elementos que las contienen. La acumulación de cargas electrostática es importante en polvos cerámicos dado su carácter aislante y debido al riesgo de explosiones por descarga. En este trabajo se estudian los principales factores que afectan a la aparición de carga neta y la tribocarga en las partículas de polvo cerámico. En polvos cerámicos de alúmina se ha comprobado que las partículas más finas presentan un aumento de la carga electrostática con una polaridad negativa. Se ha observado una correlación entre la naturaleza de los grupos OH- superficiales y la carga electrostática. La carga neta y la tribocarga en polvos cerámicos se pueden reducir si se compensan los sitios superficiales que soportan dicha carga. La dispersión en seco de nanopartículas sobre micropartículas permite la

  19. Carga de enfermedad por cáncer en santander, colombia, 2005

    OpenAIRE

    Esquiaqui Felipe, Rafael Enrique; Posso Valencia, Héctor Jaime; Peñaloza Quintero, Rolando Enrique; Rodríguez García, Jesús

    2012-01-01

    Objetivo Determinar la carga de la enfermedad por cáncer en Santander a través de los años de vida ajustados por discapacidad (AVISA). Métodos Estudio descriptivo de carga de la  enfermedad para determinar los AVISA producidos por Cáncer en Santander. La unidad de análisis fueron los registros del Observatorio Poblacional de Cáncer  de la Universidad Autónoma de Bucaramanga  y el registro de mortalidad del Departamento Administrativo Nacional de Estadísticas del año 2005. Resultados La carg...

  20. Reforma de edificios antiguos. El rasgado de huecos en muros de carga

    OpenAIRE

    Soto Pardo, M.

    1985-01-01

    La apertura de huecos en muros de carga es una operación frecuente en la reforma de edificios antiguos. Una correcta ejecución exige la puesta en carga de la estructura sustentante —normalmente un pórtico metálico— mediante gatos hidráulicos o algo similar, cosa que suele omitirse, dando lugar a dos problemas diferentes: uno, el desprendimiento diferido del área de descarga, con alarmantes fisuraciones y otro, sin efectos ostensibles, pero mucho más peligroso, como es la sobrecarga elevadísim...

  1. Diseño de celda de carga optoelectrónica

    Directory of Open Access Journals (Sweden)

    Francisco J. Martínez Serrano

    2008-01-01

    Full Text Available Los sistemas de medición representan una herramienta indispensable en todas las actividades productivas, y en el caso de empresas que aprovechan los avances del desarrollo tecnológico para mejorar la calidad de sus productos éstos son fundamentales. Frecuentemente en la industria de la manufactura metalmecánica se requiere controlar con gran precisión el ajuste de dos piezas ensambladas a presión, los materiales de ingeniería deben someterse constantemente a pruebas de resistencia, los equipos de pruebas de balanceo y vibraciones mecánicas funcionan bajo el principio de medición de fuerzas. Los métodos de medición más precisos utilizan dispositivos electromecánicos conocidos como celdas de carga, que consisten básicamente en una fina resistencia eléctrica adherida a un elemento mecánico sometido directamente o no, a las cargas de trabajo. Las cargas cíclicas que sufre el elemento mecánico afectan igualmente a la resistencia eléctrica, y debido a que está hecha de un alambre muy delgado, su capacidad a resistir elásticamente deformación es limitada. Con este proyecto se pretende construir una celda de carga opto-mecatrónica, cuyo principio de funcionamiento está basado en que gracias a la aplicación de carga en un elemento mecánico, se produce en éste cierta deformación. Esta deformación reduce la distancia entre el emisor y el receptor, provocando un cambio en la señal eléctrica. Cabe señalar que la distribución de intensidad luminosa varía entre el emisor y el receptor debido al desplazamiento generado (R. Jones, 1985; Martínez, 2004. A la celda de carga se le adaptó un emisor de infrarrojo cuya señal es recibida por el detector en el otro extremo. Se pretende demostrar que este sistema optoelectrónico es capaz de medir cargas externas sobre un elemento mecánico a través de un método indirecto para medir esfuerzos. Se ha implementado un prototipo sensible a deformación inducida a un elemento mec

  2. Carga de enfermedad por lesiones de causa externa, Casanare, Colombia, 2008-2012

    OpenAIRE

    Castañeda Porras, Oneida

    2017-01-01

    Introducción. La vigilancia de las lesiones de causa externa (LCE) es una preocupación mundial, dada la magnitud del daño, invalidez y muerte que provocan. Contar con el análisis de carga de enfermedad a nivel departamental permite disponer de información actualizada para la toma de decisiones y la planeación en salud. Objetivo Estimar la carga de enfermedad por LCE en el departamento de Casanare durante el período 2008-2012. Métodos. Estudio descriptivo retrospectivo a partir ...

  3. Capacidad de carga de las playas en el Litoral Catalán

    OpenAIRE

    García Guinduláin, Alejandro

    2005-01-01

    En la presente tesina se desarrolla el concepto de capacidad de carga recreativa. Se establecen las variables más relevantes y se evalúa el estado actual de las playas del litoral catalán y su evolución en las últimas décadas en función del tipo de playa y de su localización. Finalmente se presenta un modelo de clasificación de las playas en función de su capacidad de carga recreativa.

  4. O toque afetivo na visão do enfermeiro La concepción del enfermero sobre el tacto afectivo Affective touch according the nurse's perspective

    Directory of Open Access Journals (Sweden)

    Andréa Basílio Dias

    2008-10-01

    Full Text Available Este trabalho objetivou investigar a concepção do enfermeiro sobre o toque afetivo como ferramenta da promoção de cuidado e identificar o seu significado no cuidado de enfermagem e o momento onde ele é utilizado como instrumento de cuidado. Pesquisa qualitativa diferenciando duas maneiras de tocar: toque instrumental (cuidado objetivo e o toque afetivo (cuidado subjetivo. Na coleta de dados, utilizou-se entrevista semi-estruturada, com sete enfermeiras assistenciais de dois hospitais de médio porte de uma cidade da Regiâo Sul do Brasil. Através da análise dos dados demonstrou-se a utilização do toque afetivo restritamente, durante os procedimentos invasivos, mesmo considerando-o efetivo instrumento para estabelecer empatia.Este trabajo tuvo como objetivo investigar la concepción del enfermero universitário sobre el toque afectivo como herramienta de promoción del cuidado e identificar su significado en el cuidado de enfermería y el momento en lo cual es utilizado como instrumiento de cuidado. Investigación cualitativa diferenciando dos maneras de tocar; toque instrumental (cuidado objetivo y el toque afectivo (cuidado subjetivo. Para la recolección de datos se utilizó la entrevista semi-estructurada, con siete enfermeras asistenciales de dos hospitales de mediano porte en el sur del brasil. A través del análisis de los resultados se demonstró la utilización del toque afectivo restrictamente, durante los procedimientos invasivos, mismo considerandolo efectivo el instrumento para establecer empatia.This study aimed at investigating the conception of nurses about the affective touch as a tool for care promotion and to identify its meanings in nursing care and the moment when it is used as care instrument. Qualitative research differentiating two ways to touch: instrumental touch (objective care and the affective touch (subjective care. For data collection a semi-structured interview was used, with three assistance nurses of

  5. Electronic monitoring in bipolar disorder.

    Science.gov (United States)

    Faurholt-Jepsen, Maria

    2018-03-01

    Major reasons for the insufficient effects of current treatment options in bipolar disorder include delayed intervention for prodromal depressive and manic symptoms and decreased adherence to psychopharmacological treatment. The reliance on subjective information and clinical evaluations when diagnosing and assessing the severity of depressive and manic symptoms calls for less biased and more objective markers. By using electronic devices, fine-grained data on complex psychopathological aspects of bipolar disorder can be evaluated unobtrusively over the long term. Moreover, electronic data could possibly represent candidate markers of diagnosis and illness activity in bipolar disorder and allow for early and individualized intervention for prodromal symptoms outside clinical settings. 
The present dissertation concerns the use of electronic monitoring as a marker and treatment intervention in bipolar disorder and investigated the scientific literature and body of evidence within the area, which includes ten original study reports and two systematic reviews, one of which included a meta-analysis, conducted by the author of the dissertation. 
Taken together, the literature presented in this dissertation illustrates that 1) smartphone-based electronic self-monitoring of mood seems to reflect clinically assessed depressive and manic symptoms and enables the long-term characterization of mood

instability in bipolar disorder; 2) preliminary results suggest that smartphone-based automatically generated data (e.g. the number of text messages sent/day; the number of incoming and outgoing calls/day; the number of changes in cell tower IDs/day; and voice features) seem to reflect clinically assessed depressive and manic symptoms in bipolar disorder; 3) smartphone-based electronic self-monitoring had no effects on the severity of depressive and manic symptoms in bipolar disorder, according to a randomized controlled trial; and 4) electronic monitoring of psychomotor

  6. Mixed features in bipolar disorder.

    Science.gov (United States)

    Solé, Eva; Garriga, Marina; Valentí, Marc; Vieta, Eduard

    2017-04-01

    Mixed affective states, defined as the coexistence of depressive and manic symptoms, are complex presentations of manic-depressive illness that represent a challenge for clinicians at the levels of diagnosis, classification, and pharmacological treatment. The evidence shows that patients with bipolar disorder who have manic/hypomanic or depressive episodes with mixed features tend to have a more severe form of bipolar disorder along with a worse course of illness and higher rates of comorbid conditions than those with non-mixed presentations. In the updated Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5), the definition of "mixed episode" has been removed, and subthreshold nonoverlapping symptoms of the opposite pole are captured using a "with mixed features" specifier applied to manic, hypomanic, and major depressive episodes. However, the list of symptoms proposed in the DSM-5 specifier has been widely criticized, because it includes typical manic symptoms (such as elevated mood and grandiosity) that are rare among patients with mixed depression, while excluding symptoms (such as irritability, psychomotor agitation, and distractibility) that are frequently reported in these patients. With the new classification, mixed depressive episodes are three times more common in bipolar II compared with unipolar depression, which partly contributes to the increased risk of suicide observed in bipolar depression compared to unipolar depression. Therefore, a specific diagnostic category would imply an increased diagnostic sensitivity, would help to foster early identification of symptoms and ensure specific treatment, as well as play a role in suicide prevention in this population.

  7. Integrated Neurobiology of Bipolar Disorder

    Science.gov (United States)

    Maletic, Vladimir; Raison, Charles

    2014-01-01

    From a neurobiological perspective there is no such thing as bipolar disorder. Rather, it is almost certainly the case that many somewhat similar, but subtly different, pathological conditions produce a disease state that we currently diagnose as bipolarity. This heterogeneity – reflected in the lack of synergy between our current diagnostic schema and our rapidly advancing scientific understanding of the condition – limits attempts to articulate an integrated perspective on bipolar disorder. However, despite these challenges, scientific findings in recent years are beginning to offer a provisional “unified field theory” of the disease. This theory sees bipolar disorder as a suite of related neurodevelopmental conditions with interconnected functional abnormalities that often appear early in life and worsen over time. In addition to accelerated loss of volume in brain areas known to be essential for mood regulation and cognitive function, consistent findings have emerged at a cellular level, providing evidence that bipolar disorder is reliably associated with dysregulation of glial–neuronal interactions. Among these glial elements are microglia – the brain’s primary immune elements, which appear to be overactive in the context of bipolarity. Multiple studies now indicate that inflammation is also increased in the periphery of the body in both the depressive and manic phases of the illness, with at least some return to normality in the euthymic state. These findings are consistent with changes in the hypothalamic–pituitary–adrenal axis, which are known to drive inflammatory activation. In summary, the very fact that no single gene, pathway, or brain abnormality is likely to ever account for the condition is itself an extremely important first step in better articulating an integrated perspective on both its ontological status and pathogenesis. Whether this perspective will translate into the discovery of innumerable more homogeneous forms of

  8. Os efeitos da idade na seleção de carga perceptual

    Directory of Open Access Journals (Sweden)

    Vanessa Coelho de Sousa

    Full Text Available Algumas pesquisas sugerem a existência de momentos distintos de maturação do sistema atentivo. O presente estudo investigou os padrões de seleção da informação visual através de uma tarefa de carga perceptual executada por três grupos etários: crianças, adultos e idosos. De maneira geral os resultados obtidos indicaram uma diminuição da eficiência no processo de seleção da informação em condições de baixa carga perceptual na população de idosos e uma diminuição da eficiência da seleção em condições de alta e baixa carga perceptual na população composta por crianças. Estes resultados sugerem a existência de padrões específicos na seleção da informação visual em função da idade e da carga perceptual a ser processada pelo sistema visual.

  9. Monitoramento da carga interna de treinamento em jogadores de futsal ao longo de uma temporada

    Directory of Open Access Journals (Sweden)

    Bernardo Miloski

    2012-10-01

    Full Text Available http://dx.doi.org/10.5007/1980-0037.2012v14n6p671 Existe a necessidade de estudos sobre métodos para controle da carga e descri­ção da periodização em equipes de futsal. O objetivo do estudo foi descrever e analisar a carga interna de treinamento em um macrociclo de futsal utilizando-se o método de Percepção Subjetiva do Esforço da sessão. A amostra foi composta por 13 atletas de Liga Nacional. Calculou-se carga de treinamento semanal total (CTST, monotonia e strain durante 37 semanas. Utilizando Teste t de Student pareado, o período de preparação (PP apresentou CTST, strain e monotonia maiores que o competitivo (PC. Utilizando ANOVA de medi­das repetidas, seguida pelo post-hoc de Bonferroni, observaram-se diferenças significativas para CTST entre mesociclos: 1 > 2, 4, 5, 6, 8, 9; 7 > 4, 5, 8, 9; 2, 3 e 6 > 5, 8, 9; 4 > 5; 8 > 5 (p>0,05. As cargas de treinamento (CT foram mais elevadas no PP com redução no PC. A CT apresenta uma característica ondulatória, adaptando-se ao calendário competitivo.

  10. Marcadores periféricos e a fisiopatologia do transtorno bipolar

    Directory of Open Access Journals (Sweden)

    Pedro V. S. Magalhães

    2012-01-01

    Full Text Available INTRODUÇÃO: O entendimento da fisiopatologia do transtorno bipolar vem tendo avanços consistentes nos últimos anos. Um enfoque na relação entre carga alostática e alterações sistêmicas vem tomando corpo, com o objetivo de se entender a frequente progressão da doença. Proeminentes entre os mediadores periféricos têm sido as moléculas que poderiam ser amplamente agrupadas em neurotrofinas, marcadores de estresse oxidativo e marcadores inflamatórios. OBJETIVO: Descrever achados recentes em relação à fisiopatologia sistêmica do transtorno bipolar, com enfoque especial em estudos brasileiros, tentando articular uma visão coerente do conhecimento atual do campo. MÉTODO: Revisão narrativa da literatura relacionada a neurotrofinas, estresse oxidativo e marcadores inflamatórios no transtorno bipolar. RESULTADOS: Diversas fontes de evidência, provenientes tanto de estudos pré-clínicos quanto clínicos, revelam consistentemente alterações sistêmicas no transtorno bipolar. Os achados são especialmente robustos em pacientes com múltiplos episódios. Nesses, alterações relacionadas a episódios de mania e depressão são notáveis em neurotrofinas e dano oxidativo a lipídeos. Um número menor de estudos mostra alterações no sistema imune, em particular estados pró-inflamatórios. CONCLUSÃO: Alterações sistêmicas que correlacionam o transtorno bipolar a comorbidade clínica, disfunção cognitiva, incapacidade e mortalidade precoce começam a ser traçadas. Estudos envolvendo desenhos longitudinais, amostras populacionais e ensaios clínicos envolvendo marcadores periféricos devem ser incorporados no futuro próximo e reforçar a validade de uma noção de envolvimento multissistêmico no transtorno bipolar.

  11. Bipolar polygenic loading and bipolar spectrum features in major depressive disorder

    NARCIS (Netherlands)

    Wiste, Anna; Robinson, Elise B.; Milaneschi, Yuri; Meier, Sandra; Ripke, Stephan; Clements, Caitlin C.; Fitzmaurice, Garrett M.; Rietschel, Marcella; Penninx, Brenda W.; Smoller, Jordan W.; Perlis, Roy H.

    Objectives Family and genetic studies indicate overlapping liability for major depressive disorder and bipolar disorder. The purpose of the present study was to determine whether this shared genetic liability influences clinical presentation. Methods A polygenic risk score for bipolar disorder,

  12. Unsplit bipolar pulse forming line

    Science.gov (United States)

    Rhodes, Mark A [Pleasanton, CA

    2011-05-24

    A bipolar pulse forming transmission line module and system for linear induction accelerators having first, second, third, and fourth planar conductors which form a sequentially arranged interleaved stack having opposing first and second ends, with dielectric layers between the conductors. The first and second planar conductors are connected to each other at the first end, and the first and fourth planar conductors are connected to each other at the second end via a shorting plate. The third planar conductor is electrically connectable to a high voltage source, and an internal switch functions to short at the first end a high voltage from the third planar conductor to the fourth planar conductor to produce a bipolar pulse at the acceleration axis with a zero net time integral. Improved access to the switch is enabled by an aperture through the shorting plate and the proximity of the aperture to the switch.

  13. Course of Subthreshold Bipolar Disorder in Youth: Diagnostic Progression from Bipolar Disorder Not Otherwise Specified

    Science.gov (United States)

    Axelson, David A.; Birmaher, Boris; Strober, Michael A.; Goldstein, Benjamin I.; Ha, Wonho; Gill, Mary Kay; Goldstein, Tina R.; Yen, Shirley; Hower, Heather; Hunt, Jeffrey I.; Liao, Fangzi; Iyengar, Satish; Dickstein, Daniel; Kim, Eunice; Ryan, Neal D.; Frankel, Erica; Keller, Martin B.

    2011-01-01

    Objective: To determine the rate of diagnostic conversion from an operationalized diagnosis of bipolar disorder not otherwise specified (BP-NOS) to bipolar I disorder (BP-I) or bipolar II disorder (BP-II) in youth over prospective follow-up and to identify factors associated with conversion. Method: Subjects were 140 children and adolescents…

  14. Bipolar (spectrum) disorder and mood stabilization: standing at the crossroads?

    OpenAIRE

    De Fruyt, Jurgen; Demyttenaere, Koen

    2007-01-01

    Diagnosis and treatment of bipolar disorder has long been a neglected discipline. Recent years have shown an upsurge in bipolar research. When compared to major depressive disorder, bipolar research still remains limited and more expert based than evidence based. In bipolar diagnosis the focus is shifting from classic mania to bipolar depression and hypomania. There is a search for bipolar signatures in symptoms and course of major depressive episodes. The criteria for hypomania are softened,...

  15. [Bipolar disorders in DSM-5].

    Science.gov (United States)

    Severus, E; Bauer, M

    2014-05-01

    In spring 2013 the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) edited by the American Psychiatric Association was published. The DSM-5 has also brought some important changes regarding bipolar disorders. The goal of this manuscript is to review the novelties in DSM-5 and to evaluate the implications of these changes. The diagnostic criteria as well as the additional remarks provided in the running text of DSM-5 were carefully appraised. For the first time diagnostic criteria are provided for disorders which up to now have been considered as subthreshold bipolar disorders. Furthermore, mixed episodes were eliminated and instead a mixed specifier was introduced. An increase in goal-directed activity/energy is now one of the obligatory symptoms for a (hypo)manic episode. Diagnostic guidance is provided as to when a (hypo)manic episode that has developed during treatment with an antidepressant has to be judged to be causally related to antidepressants and when this episode has only occurred coincidentally with antidepressant use. While some of the novelties are clearly useful, e.g. addition of increased goal-directed activity/energy as obligatory symptom for (hypo)manic episodes, this remains to be demonstrated for others, such as the definition of various subthreshold bipolar disorders.

  16. Bipolar Disorder and Obsessive Compulsive Disorder Comorbidity

    Directory of Open Access Journals (Sweden)

    Necla Keskin

    2014-08-01

    Full Text Available The comorbidity of bipolar disorder and anxiety disorders is a well known concept. Obsessive-compulsive disorder is the most commonly seen comorbid anxiety disorder in bipolar patients. Some genetic variants, neurotransmitters especially serotonergic systems and second-messenger systems are thought to be responsible for its etiology. Bipolar disorder alters the clinical aspects of obsessive compulsive disorder and is associated with poorer outcome. The determination of comorbidity between bipolar disorder and obsessive compulsive disorder is quite important for appropriate clinical management and treatment. [Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry 2014; 6(4.000: 429-437

  17. Bipolar mixed features - Results from the comparative effectiveness for bipolar disorder (Bipolar CHOICE) study.

    Science.gov (United States)

    Tohen, Mauricio; Gold, Alexandra K; Sylvia, Louisa G; Montana, Rebecca E; McElroy, Susan L; Thase, Michael E; Rabideau, Dustin J; Nierenberg, Andrew A; Reilly-Harrington, Noreen A; Friedman, Edward S; Shelton, Richard C; Bowden, Charles L; Singh, Vivek; Deckersbach, Thilo; Ketter, Terence A; Calabrese, Joseph R; Bobo, William V; McInnis, Melvin G

    2017-08-01

    DSM-5 changed the criteria from DSM-IV for mixed features in mood disorder episodes to include non-overlapping symptoms of depression and hypomania/mania. It is unknown if, by changing these criteria, the same group would qualify for mixed features. We assessed how those meeting DSM-5 criteria for mixed features compare to those meeting DSM-IV criteria. We analyzed data from 482 adult bipolar patients in Bipolar CHOICE, a randomized comparative effectiveness trial. Bipolar diagnoses were confirmed through the MINI International Neuropsychiatric Interview (MINI). Presence and severity of mood symptoms were collected with the Bipolar Inventory of Symptoms Scale (BISS) and linked to DSM-5 and DSM-IV mixed features criteria. Baseline demographics and clinical variables were compared between mood episode groups using ANOVA for continuous variables and chi-square tests for categorical variables. At baseline, the frequency of DSM-IV mixed episodes diagnoses obtained with the MINI was 17% and with the BISS was 20%. Using DSM-5 criteria, 9% of participants met criteria for hypomania/mania with mixed features and 12% met criteria for a depressive episode with mixed features. Symptom severity was also associated with increased mixed features with a high rate of mixed features in patients with mania/hypomania (63.8%) relative to those with depression (8.0%). Data on mixed features were collected at baseline only and thus do not reflect potential patterns in mixed features within this sample across the study duration. The DSM-5 narrower, non-overlapping definition of mixed episodes resulted in fewer patients who met mixed criteria compared to DSM-IV. Copyright © 2017. Published by Elsevier B.V.

  18. Influencia de Las Cargas Térmicas Sobre Flujos de Aire Generados en Una Habitacíon

    DEFF Research Database (Denmark)

    Olmedo, Inés; Ruiz de Adana Santiago, Manuel; Nielsen, Peter V.

    2011-01-01

    El flujo de aire en el interior de un local generado con un sistema de ventilación y difusión de aire puede verse afectado por las cargas térmicas internas del local. En este trabajo, se estudia la influencia de las cargas térmicas internas debidas a personas en el flujo de aire interior de un lo...

  19. Comportamiento de tejas de cubierta tipo multicapa fabricadas con asfalto crudo y modificado cuando son sometidas a cargas constantes

    OpenAIRE

    López Bula, Pedro Javier

    2011-01-01

    El presente trabajo, analiza las propiedades viscoelasticas de diferentes materiales asfalticos después de ser sometidos a cargas permanentes y a diferente temperatura -- Estas cargas simulan las que eventualmente se pueden presentar en la aplicacion y fabricación de productos asfalticos ampliamente utilizados en el sector de la construcción -- Para este estudio se utilizó asfalto crudo y modificado con diferentes polímeros: Cera de polietileno (CERA), caucho molido de llanta (CR), copolimero...

  20. [Thinking organization and defense mechanisms in bipolar disorders. Clinical and psychopathological study on bipolar I and bipolar II].

    Science.gov (United States)

    Lo Baido, Rosa; Di Blasi, Marie; Alfano, Pietro; Audino, Palma; Bellavia, Carmela; Blando, Anna Antonia; Merendino, Adelaide; Messina, Rossana; Poma, Maria Luisa; La Grutta, Sabina

    2013-01-01

    The aim of this research is to explore the psychical functioning in bipolar I or bipolar II disorder people through the analysis and comparison of their thought styles and defense patterns. 29 bipolar I and bipolar II people afferent to Palermo University Policlinical Psychriatic Hospital Department were selected during the whole 2009-2010 year. The following tests were administred: Wechsler Adult Intelligent Scale-R (WAIS-R) in order to measure the general cognitive function; Defense Mechanisms Inventory (DMI) in order to measure defense patterns. Afterwards, the results of the two tests were analysed and compared. Bipolar disorder people use cognitive mechanisms and defense strategies that are very different from standard population. Bipolar I subjects show both wider and more serious cognitive deterioration and stricter defense mechanisms than bipolar II subjects. Generally bipolar patients show an immature personality based on archaic mechanisms that can be found in all the spheres of their personality: emotions, cognition, Ego-strength, adaptability to reality. The peculiar achieved cognitive and defense profile leads to important considerations about how psychological strategies can contribute to use "bespoke" treatments for these patients.

  1. Carga diferida en implantología Delayed loading in implantology

    Directory of Open Access Journals (Sweden)

    J.C. de Vicente Rodríguez

    2005-10-01

    Full Text Available La implantología dental se ha convertido en una práctica con bases científicas con el descubrimiento de la biología de la oseointegración. El protocolo terapéutico clásico implicaba mantener los implantes libres de carga hasta que estuviesen oseointegrados. Sin embargo, las desventajas de este procedimiento condujeron posteriormente al desarrollo de un nuevo protocolo, en el que los implantes son cargados de forma inmediata tras su colocación. Sin embargo, este nuevo abordaje suscita dudas acerca de su destino último que aún no han sido resueltas. El objetivo del presente artículo es (i revisar y analizar críticamente las bases biológicas de la carga de los implantes y (ii proponer guías orientativas para elegir el momento ideal de carga de los mismos, en función de variables clínicas. Como conclusión, se establece que si bien las cargas inmediata y diferida proporcionan los mismos resultados en diversas situaciones, la segunda es preferible en presencia de determinados factores de riesgo para el éxito de la primera.Implant dentistry has become a scientifically based practice with the discovery of the biological basis of osseointegration. In the classical protocol, implants were load-free while bone was healing around them to ensure predictable osseointegration. However, several disadvantages of this approach have lead recently to a new protocol based on loading implants immediately after their placement. But, several questions about the outcome of this approach remain unanswered. Therefore, the aim of the present review article is to (i review and analyze critically the biological basis of the load of implants, and (ii propose guidelines for choosing the ideal moment to load dental implants, based on clinical variables. As a conclusion, delayed loading of implants remains the best protocol in several clinical situations.

  2. Uso público y capacidad de carga perceptual en espacios naturales protegidos

    Directory of Open Access Journals (Sweden)

    Felipe Leco Berrocal

    2013-01-01

    Full Text Available Este trabajo muestra algunos de los resultados de la investigación realizada en el Proyecto «Las áreas de uso público en la Reserva de la Biosfera de Monfragüe. Accesibilidad y capacidad de carga» (Plan Nacional de Investigación Científica, Desarrollo e Innovación Tecnológica 2004-2007. Orden MAM/321/207. Expte. 024/SGTB/2007/4.1. En líneas generales, se presenta un estudio de las principales áreas de uso público desde la perspectiva de la capacidad de carga, ya que dichas áreas polarizan por regla general los flujos de usuarios, las inversiones y son el eje principal sobre el que descansa la afluencia de usuarios al Parque, por ello es necesario evaluar no sólo la capacidad de carga sino también la intensidad de su uso.

  3. Análisis de grupos de pilotes sometidos a cargas de sismo

    Directory of Open Access Journals (Sweden)

    Carlos Javier Sainea Vargas

    2012-05-01

    Full Text Available Se presentan los análisis de los resultados obtenidos al emplear la metodología p-y en el análisis de un amplio número de modelos de grupos de pilotes, en los que se aplicaron modificaciones a las curvas p-y para la inclusión de los efectos de grupo y carga sísmica; dichos modelos han sido elaborados incluyendo diferentes configuraciones geométricas de los grupos, y varios tipos de suelos de cimentación. Para el análisis de los modelos se ha empleado el software especializado FB-Multipier, que, además de incluir la metodología elegida, permite la aplicación de cargas sísmicas reales, como las dadas por señales acelerográficas. A partir de los resultados de deflexiones y momentos obtenidos en el análisis de losmodelos, se presentan algunas observaciones sobre el comportamiento de los grupos de pilotes sometidos a carga sísmica y se incluyen consideraciones referentes a su diseño.

  4. Análisis de grupos de pilotes sometidos a cargas de sismo

    Directory of Open Access Journals (Sweden)

    Carlos Javier Sainea Vargas

    2011-07-01

    Full Text Available Se presentan los análisis de los resultados obtenidos al emplear la metodología p-y en el análisis de un amplio número de modelos de grupos de pilotes, en los que se aplicaron modificaciones a las curvas p-y para la inclusión de los efectos de grupo y carga sísmica; dichos modelos han sido elaborados incluyendo diferentes configuraciones geométricas de los grupos, y varios tipos de suelos de cimentación. Para el análisis de los modelos se ha empleado el software especializado FB-Multipier, que, además de incluir la metodología elegida, permite la aplicación de cargas sísmicas reales, como las dadas por señales acelerográficas. A partir de los resultados de deflexiones y momentos obtenidos en el análisis de losmodelos, se presentan algunas observaciones sobre el comportamiento de los grupos de pilotes sometidos a carga sísmica y se incluyen consideraciones referentes a su diseño.

  5. O insight no transtorno bipolar: uma revisão sistemática

    Directory of Open Access Journals (Sweden)

    Rafael de Assis da Silva

    2014-09-01

    Full Text Available Objetivos Realizar uma revisão sistemática para compreender que fatores estão relacionados a uma maior ou menor consciência de morbidade no transtorno bipolar (TB, como o insight varia em função do estado afetivo e estabelecer uma comparação com outros transtornos mentais. Métodos Realizou-se uma revisão sistemática da literatura científica sobre o insight em pacientes com TB. Foram buscados estudos clínicos originais sobre o tema nas bases de dados Medline, ISI e SciELO. Os termos de busca empregados foram: “insight” OR “awareness” AND “bipolar” OR “mania” OR “manic”. Resultados Foram selecionados 55 artigos. O insight no TB parece ser mais prejudicado do que na depressão unipolar, porém menos do que na esquizofrenia. Com relação ao TB, um menor nível de insight está relacionado à presença de sintomas psicóticos e de alterações cognitivas. Além disso, um comprometimento do insight está associado a uma menor adesão ao tratamento. Por outro lado, uma maior preservação do insight pode estar associada a maior ideação suicida. Finalmente, a fase maníaca cursa com um nível inferior de insight quando comparada à fase depressiva ou de eutimia. Conclusão No TB, o insight está significativamente prejudicado, especialmente na mania. Diversos fatores clínicos parecem influenciar o nível de insight.

  6. Poorer sustained attention in bipolar I than bipolar II disorder

    Directory of Open Access Journals (Sweden)

    Chen Shih-Heng

    2010-02-01

    Full Text Available Abstract Background Nearly all information processing during cognitive processing takes place during periods of sustained attention. Sustained attention deficit is among the most commonly reported impairments in bipolar disorder (BP. The majority of previous studies have only focused on bipolar I disorder (BP I, owing to underdiagnosis or misdiagnosis of bipolar II disorder (BP II. With the refinement of the bipolar spectrum paradigm, the goal of this study was to compare the sustained attention of interepisode patients with BP I to those with BP II. Methods In all, 51 interepisode BP patients (22 with BP I and 29 with BP II and 20 healthy controls participated in this study. The severity of psychiatric symptoms was assessed by the 17-item Hamilton Depression Rating Scale and the Young Mania Rating Scale. All participants undertook Conners' Continuous Performance Test II (CPT-II to evaluate sustained attention. Results After controlling for the severity of symptoms, age and years of education, BP I patients had a significantly longer reaction times (F(2,68 = 7.648, P = 0.001, worse detectability (d' values (F(2,68 = 6.313, P = 0.003 and more commission errors (F(2,68 = 6.182, P = 0.004 than BP II patients and healthy controls. BP II patients and controls scored significantly higher than BP I patients for d' (F = 6.313, P = 0.003. No significant difference was found among the three groups in omission errors and no significant correlations were observed between CPT-II performance and clinical characteristics in the three groups. Conclusions These findings suggested that impairments in sustained attention might be more representative of BP I than BP II after controlling for the severity of symptoms, age, years of education and reaction time on the attentional test. A longitudinal follow-up study design with a larger sample size might be needed to provide more information on chronological sustained attention deficit in BP patients, and to illustrate

  7. Swimming in Deep Water: Childhood Bipolar Disorder

    Science.gov (United States)

    Senokossoff, Gwyn W.; Stoddard, Kim

    2009-01-01

    The authors focused on one parent's struggles in finding a diagnosis and intervention for a child who had bipolar disorder. The authors explain the process of identification, diagnosis, and intervention of a child who had bipolar disorder. In addition to the personal story, the authors provide information on the disorder and outline strategies…

  8. Bipolar disorder diagnosis: challenges and future directions

    Science.gov (United States)

    Phillips, Mary L; Kupfer, David J

    2018-01-01

    Bipolar disorder refers to a group of affective disorders, which together are characterised by depressive and manic or hypomanic episodes. These disorders include: bipolar disorder type I (depressive and manic episodes: this disorder can be diagnosed on the basis of one manic episode); bipolar disorder type II (depressive and hypomanic episodes); cyclothymic disorder (hypomanic and depressive symptoms that do not meet criteria for depressive episodes); and bipolar disorder not otherwise specified (depressive and hypomanic-like symptoms that do not meet the diagnostic criteria for any of the aforementioned disorders). Bipolar disorder type II is especially difficult to diagnose accurately because of the difficulty in differentiation of this disorder from recurrent unipolar depression (recurrent depressive episodes) in depressed patients. The identification of objective biomarkers that represent pathophysiologic processes that differ between bipolar disorder and unipolar depression can both inform bipolar disorder diagnosis and provide biological targets for the development of new and personalised treatments. Neuroimaging studies could help the identification of biomarkers that differentiate bipolar disorder from unipolar depression, but the problem in detection of a clear boundary between these disorders suggests that they might be better represented as a continuum of affective disorders. Innovative combinations of neuroimaging and pattern recognition approaches can identify individual patterns of neural structure and function that accurately ascertain where a patient might lie on a behavioural scale. Ultimately, an integrative approach, with several biological measurements using different scales, could yield patterns of biomarkers (biosignatures) to help identify biological targets for personalised and new treatments for all affective disorders. PMID:23663952

  9. Transient Stuttering in Catatonic Bipolar Patients

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    Anthony B. Joseph

    1991-01-01

    Full Text Available Two cases of transient stuttering occurring in association with catatonia and bipolar disorder are described. Affective decompensation has been associated with lateralized cerebral dysfunction, and it is hypothesized that in some bipolar catatonic patients a concomitant disorder of the lateralization of language function may lead to a variety of clinical presentations including aphasia, mutism, and stuttering.

  10. Cognitive behavioral therapy for bipolar disorders

    OpenAIRE

    Lotufo Neto, Francisco

    2004-01-01

    Descrição dos objetivos e principais técnicas da terapia comportamental cognitiva usadas para a psicoterapia das pessoas com transtorno bipolar.Objectives and main techniques of cognitive behavior therapy for the treatment of bipolar disorder patients are described.

  11. NO signaling in retinal bipolar cells.

    Science.gov (United States)

    Agurto, A; Vielma, A H; Cadiz, B; Couve, E; Schmachtenberg, O

    2017-08-01

    Nitric oxide (NO) is a neuromodulator involved in physiological and pathological processes in the retina. In the inner retina, a subgroup of amacrine cells have been shown to synthesize NO, but bipolar cells remain controversial as NO sources. This study correlates NO synthesis in dark-adapted retinas, through labeling with the NO marker DAF-FM, with neuronal nitric oxide synthase (nNOS) and inducible NOS expression, and presence of the NO receptor soluble guanylate cyclase in bipolar cells. NO containing bipolar cells were morphologically identified by dialysis of DAF fluorescent cells with intracellular dyes, or by DAF labeling followed by immunohistochemistry for nNOS and other cellular markers. DAF fluorescence was observed in all types of bipolar cells that could be identified, but the most intense DAF fluorescence was observed in bipolar cells with severed processes, supporting pathological NO signaling. Among nNOS expressing bipolar cells, type 9 was confirmed unequivocally, while types 2, 3a, 3b, 4, 5, 7, 8 and the rod bipolar cell were devoid of this enzyme. These results establish specific bipolar cell types as NO sources in the inner retina, and support the involvement of NO signaling in physiological and pathological processes in the inner retina. Copyright © 2017 Elsevier Ltd. All rights reserved.

  12. Carga de salmonelosis y shigelosis en cuatro departamentos de Guatemala, 2010

    Directory of Open Access Journals (Sweden)

    Sheilee L. Díaz

    Full Text Available OBJETIVO: Estimar la carga de enfermedad por Salmonella spp. y Shigella spp. en cuatro departamentos de Guatemala en 2010. MÉTODOS: Estudio de carga de enfermedad basado en el análisis documental de las encuestas poblacionales publicadas, los archivos de laboratorio y los datos de vigilancia del Sistema de Información Gerencial de Salud (SIGSA de cuatro departamentos de Guatemala: Huehuetenango, Jutiapa, Quetzaltenango y Santa Rosa, en 2010. La información se complementó con una encuesta a laboratorios. La carga de enfermedad se estimó según la metodología de los Centros para el Control y la Prevención de Enfermedades de los Estados Unidos de América, adaptada por la Organización Mundial de la Salud. RESULTADOS: Se encontraron 72 casos de salmonelosis y 172 de shigelosis en los datos de vigilancia. Según las encuestas poblacionales, el porcentaje de la población que consulta los servicios de salud por diarrea es de 64,7% (IC95%: 60,6%-68,7% en Quetzaltenango y 61,0% (IC95%: 56,0%-66,0% en Santa Rosa. En los 115 laboratorios que respondieron la encuesta (tasa de respuesta: 72,8% se recolectaron 6 051 muestras sospechadas para coprocultivo y 3 290 para hemocultivo, y se procesaron 39,4% y 100,0% de ellas, respectivamente. Se aislaron 85 cepas de Salmonella spp. y 113 de Shigella spp. Se estimó que por cada caso notificado de salmonelosis y shigelosis existen 40 casos no informados en Quetzaltenango; 55 en Huehuetenango; 345 en Santa Rosa; y 466 en Jutiapa. La carga de enfermedad estimada varió entre 5 y 2 230 casos por 100 000 habitantes para salmonelosis y entre 60 y 1 195 casos por 100 000 habitantes para shigelosis. CONCLUSIONES: La salmonelosis y la shigelosis constituyen un importante problema de salud pública en los departamentos estudiados y en Guatemala. La carga de enfermedad por estos patógenos es mayor que la informada por el SIGSA.

  13. Thyroid Functions and Bipolar Affective Disorder

    Directory of Open Access Journals (Sweden)

    Subho Chakrabarti

    2011-01-01

    Full Text Available Accumulating evidence suggests that hypothalamo-pituitary-thyroid (HPT axis dysfunction is relevant to the pathophysiology and clinical course of bipolar affective disorder. Hypothyroidism, either overt or more commonly subclinical, appears to the commonest abnormality found in bipolar disorder. The prevalence of thyroid dysfunction is also likely to be greater among patients with rapid cycling and other refractory forms of the disorder. Lithium-treatment has potent antithyroid effects and can induce hypothyroidism or exacerbate a preexisting hypothyroid state. Even minor perturbations of the HPT axis may affect the outcome of bipolar disorder, necessitating careful monitoring of thyroid functions of patients on treatment. Supplementation with high dose thyroxine can be considered in some patients with treatment-refractory bipolar disorder. Neurotransmitter, neuroimaging, and genetic studies have begun to provide clues, which could lead to an improved understanding of the thyroid-bipolar disorder connection, and more optimal ways of managing this potentially disabling condition.

  14. Diagnostic stability in pediatric bipolar disorder

    DEFF Research Database (Denmark)

    Vedel Kessing, Lars; Vradi, Eleni; Andersen, Per Kragh

    2015-01-01

    BACKGROUND: The diagnostic stability of pediatric bipolar disorder has not been investigated previously. The aim was to investigate the diagnostic stability of the ICD-10 diagnosis of pediatric mania/bipolar disorder.METHODS: All patients below 19 years of age who got a diagnosis of mania/bipolar...... disorder at least once in a period from 1994 to 2012 at psychiatric inpatient or outpatient contact in Denmark were identified in a nationwide register.RESULTS: Totally, 354 children and adolescents got a diagnosis of mania/bipolar disorder at least once; a minority, 144 patients (40.7%) got the diagnosis...... at the first contact whereas the remaining patients (210; 59.3%) got the diagnosis at later contacts before age 19. For the latter patients, the median time elapsed from first treatment contact with the psychiatric service system to the first diagnosis with a manic episode/bipolar disorder was nearly 1 year...

  15. 2017 Bipolar Plate Workshop Summary Report

    Energy Technology Data Exchange (ETDEWEB)

    Kopasz, John P. [Argonne National Lab. (ANL), Argonne, IL (United States); Benjamin, Thomas G. [Argonne National Lab. (ANL), Argonne, IL (United States); Schenck, Deanna [Argonne National Lab. (ANL), Argonne, IL (United States)

    2017-08-17

    The Bipolar Plate (BP) Workshop was held at USCAR1 in Southfield, Michigan on February 14, 2017 and included 63 participants from industry, government agencies, universities, and national laboratories with expertise in the relevant fields. The objective of the workshop was to identify research and development (R&D) needs, in particular early-stage R&D, for bipolar plates for polymer electrolyte membrane (PEM) fuel cells for transportation applications. The focus of the workshop was on materials, manufacturing, and design aspects of bipolar plates with the goal of meeting DOE’s 2020 bipolar plate targets. Of special interest was the cost target of ≤$3/kW for the bipolar plate.

  16. O papel dos estados afetivos sobre os processos cognitivos de assimilação e acomodação

    Directory of Open Access Journals (Sweden)

    Maura Ribeiro Alves

    2011-12-01

    Full Text Available Este artigo objetivou investigar se o humor positivo induz ativação de conhecimento prévio (função assimilativa e se o humor negativo aciona processos cognitivos dirigidos pelos dados (função acomodativa. A amostra foi composta de 32 participantes, de ambos os sexos, com idade entre 17 e 38 anos. O experimento testou o efeito de geração ativa de conhecimento. Induziram-se inicialmente humores positivos e negativos nos participantes. A tarefa final consistiu em recordar livremente uma lista de palavras completas (favorecendo processos dirigidos pelos dados ou incompletas (favorecendo processos cognitivos dirigidos por conhecimento prévio via geração ativa, apresentadas anteriormente. Sob humor positivo, os participantes recordaram mais palavras completadas por eles durante a fase de codificação (efeito de geração ativa, sugerindo prevalência de funções assimilativas. Sob estado de humor negativo, recordaram mais palavras completas oferecidas pelo experimentador, indicando predomínio de funções acomodativas. Conclui-se que os estados afetivos atuam sobre a seleção e regulação dos processos cognitivos de assimilação e acomodação.

  17. Burnout em professores universitários: impacto de percepções de justiça e comprometimento afetivo

    Directory of Open Access Journals (Sweden)

    Ivone Félix de Sousa

    Full Text Available Esta pesquisa objetivou analisar o poder mediacional do comprometimento organizacional afetivo na relação entre as percepções de justiça distributiva, processual e interacional e o burnout. Participaram da pesquisa 233 professores universitários. Foram aplicados os instrumentos avaliativos Maslach Burnout Inventory, Escala de Percepção de Justiça Organizacional e Organizational Commitment Questionnaire. Analisou-se o poder mediacional do comprometimento na relação entre a percepção de justiça e o burnout, a partir da regressão hierárquica. O poder mediacional do comprometimento se confirmou na relação entre percepção de justiça distributiva e exaustão. Concluiu-se que a percepção de injustiça na forma de distribuição de recursos pode levar o professor universitário à exaustão, o que pode ter probabilidade aumentada diante da falta de comprometimento.

  18. Homoparentalidade feminina: laço biológico e laço afetivo na dinâmica familiar

    Directory of Open Access Journals (Sweden)

    Mônica Fortuna Pontes

    Full Text Available Resumo Este trabalho teve como objetivo estudar a dinâmica de famílias homoparentais compostas por duas mulheres com filhos que possuem vínculo biológico com somente uma delas. Foram entrevistadas nove mulheres, oito delas formando quatro casais e uma separada, com idades entre 33 e 45 anos, com filhos com idade entre 2 e 8 anos, pertencentes à camada média da população do estado do Rio de Janeiro, que fizeram conjuntamente o planejamento da maternidade por meio das novas tecnologias reprodutivas com sêmen de doador anônimo. As seguintes categorias de análise foram discutidas: terminologia de parentesco e relações afetivas; divisão de tarefas relacionadas aos cuidados com as crianças e busca por legitimidade. Verificou-se que nas constituições familiares estudadas, as crianças, de fato, identificam as duas mulheres como mães, quando ambas assim se assumem, demonstrando que o laço afetivo cumpriu o papel de vincular.

  19. Nanofluidic diode and bipolar transistor.

    Science.gov (United States)

    Daiguji, Hirofumi; Oka, Yukiko; Shirono, Katsuhiro

    2005-11-01

    Theoretical modeling of ionic distribution and transport in a nanochannel containing a surface charge on its wall, 30 nm high and 5 microm long, suggests that ionic current can be controlled by locally modifying the surface charge density through a gate electrode, even if the electrical double layers are not overlapped. When the surface charge densities at the right and left halves of a channel are the same absolute value but of different signs, this could form the basis of a nanofluidic diode. When the surface charge density at the middle part of a channel is modified, this could form the basis of a nanofluidic bipolar transistor.

  20. DeepBipolar: Identifying genomic mutations for bipolar disorder via deep learning.

    Science.gov (United States)

    Laksshman, Sundaram; Bhat, Rajendra Rana; Viswanath, Vivek; Li, Xiaolin

    2017-09-01

    Bipolar disorder, also known as manic depression, is a brain disorder that affects the brain structure of a patient. It results in extreme mood swings, severe states of depression, and overexcitement simultaneously. It is estimated that roughly 3% of the population of the United States (about 5.3 million adults) suffers from bipolar disorder. Recent research efforts like the Twin studies have demonstrated a high heritability factor for the disorder, making genomics a viable alternative for detecting and treating bipolar disorder, in addition to the conventional lengthy and costly postsymptom clinical diagnosis. Motivated by this study, leveraging several emerging deep learning algorithms, we design an end-to-end deep learning architecture (called DeepBipolar) to predict bipolar disorder based on limited genomic data. DeepBipolar adopts the Deep Convolutional Neural Network (DCNN) architecture that automatically extracts features from genotype information to predict the bipolar phenotype. We participated in the Critical Assessment of Genome Interpretation (CAGI) bipolar disorder challenge and DeepBipolar was considered the most successful by the independent assessor. In this work, we thoroughly evaluate the performance of DeepBipolar and analyze the type of signals we believe could have affected the classifier in distinguishing the case samples from the control set. © 2017 Wiley Periodicals, Inc.

  1. Comparison of depressive episodes in bipolar disorder and in major depressive disorder within bipolar disorder pedigrees.

    Science.gov (United States)

    Mitchell, Philip B; Frankland, Andrew; Hadzi-Pavlovic, Dusan; Roberts, Gloria; Corry, Justine; Wright, Adam; Loo, Colleen K; Breakspear, Michael

    2011-10-01

    Although genetic epidemiological studies have confirmed increased rates of major depressive disorder among the relatives of people with bipolar affective disorder, no report has compared the clinical characteristics of depression between these two groups. To compare clinical features of depressive episodes across participants with major depressive disorder and bipolar disorder from within bipolar disorder pedigrees, and assess the utility of a recently proposed probabilistic approach to distinguishing bipolar from unipolar depression. A secondary aim was to identify subgroups within the relatives with major depression potentially indicative of 'genetic' and 'sporadic' subgroups. Patients with bipolar disorder types 1 and 2 (n = 246) and patients with major depressive disorder from bipolar pedigrees (n = 120) were assessed using the Diagnostic Interview for Genetic Studies. Logistic regression was used to identify distinguishing clinical features and assess the utility of the probabilistic approach. Hierarchical cluster analysis was used to identify subgroups within the major depressive disorder sample. Bipolar depression was characterised by significantly higher rates of psychomotor retardation, difficulty thinking, early morning awakening, morning worsening and psychotic features. Depending on the threshold employed, the probabilistic approach yielded a positive predictive value ranging from 74% to 82%. Two clusters within the major depressive disorder sample were found, one of which demonstrated features characteristic of bipolar depression, suggesting a possible 'genetic' subgroup. A number of previously identified clinical differences between unipolar and bipolar depression were confirmed among participants from within bipolar disorder pedigrees. Preliminary validation of the probabilistic approach in differentiating between unipolar and bipolar depression is consistent with dimensional distinctions between the two disorders and offers clinical utility in

  2. A YinYang bipolar fuzzy cognitive TOPSIS method to bipolar disorder diagnosis.

    Science.gov (United States)

    Han, Ying; Lu, Zhenyu; Du, Zhenguang; Luo, Qi; Chen, Sheng

    2018-05-01

    Bipolar disorder is often mis-diagnosed as unipolar depression in the clinical diagnosis. The main reason is that, different from other diseases, bipolarity is the norm rather than exception in bipolar disorder diagnosis. YinYang bipolar fuzzy set captures bipolarity and has been successfully used to construct a unified inference mathematical modeling method to bipolar disorder clinical diagnosis. Nevertheless, symptoms and their interrelationships are not considered in the existing method, circumventing its ability to describe complexity of bipolar disorder. Thus, in this paper, a YinYang bipolar fuzzy multi-criteria group decision making method to bipolar disorder clinical diagnosis is developed. Comparing with the existing method, the new one is more comprehensive. The merits of the new method are listed as follows: First of all, multi-criteria group decision making method is introduced into bipolar disorder diagnosis for considering different symptoms and multiple doctors' opinions. Secondly, the discreet diagnosis principle is adopted by the revised TOPSIS method. Last but not the least, YinYang bipolar fuzzy cognitive map is provided for the understanding of interrelations among symptoms. The illustrated case demonstrates the feasibility, validity, and necessity of the theoretical results obtained. Moreover, the comparison analysis demonstrates that the diagnosis result is more accurate, when interrelations about symptoms are considered in the proposed method. In a conclusion, the main contribution of this paper is to provide a comprehensive mathematical approach to improve the accuracy of bipolar disorder clinical diagnosis, in which both bipolarity and complexity are considered. Copyright © 2018 Elsevier B.V. All rights reserved.

  3. Can neuroimaging disentangle bipolar disorder?

    Science.gov (United States)

    Hozer, Franz; Houenou, Josselin

    2016-05-01

    Bipolar disorder heterogeneity is large, leading to difficulties in identifying neuropathophysiological and etiological mechanisms and hindering the formation of clinically homogeneous patient groups in clinical trials. Identifying markers of clinically more homogeneous groups would help disentangle BD heterogeneity. Neuroimaging may aid in identifying such groups by highlighting specific biomarkers of BD subtypes or clinical dimensions. We performed a systematic literature search of the neuroimaging literature assessing biomarkers of relevant BD phenotypes (type-I vs. II, presence vs. absence of psychotic features, suicidal behavior and impulsivity, rapid cycling, good vs. poor medication response, age at onset, cognitive performance and circadian abnormalities). Consistent biomarkers were associated with suicidal behavior, i.e. frontal/anterior alterations (prefrontal and cingulate grey matter, prefrontal white matter) in patients with a history of suicide attempts; and with cognitive performance, i.e. involvement of frontal and temporal regions, superior and inferior longitudinal fasciculus, right thalamic radiation, and corpus callosum in executive dysfunctions. For the other dimensions and sub-types studied, no consistent biomarkers were identified. Studies were heterogeneous both in methodology and outcome. Though theoretically promising, neuroimaging has not yet proven capable of disentangling subtypes and dimensions of bipolar disorder, due to high between-study heterogeneity. We issue recommendations for future studies. Copyright © 2016 Elsevier B.V. All rights reserved.

  4. CARGA ÓTIMA DE FRUTOS NA MACIEIRA ‘PRINCESA’ DE BAIXO REQUERIMENTO EM FRIO INVERNAL:RESULTADOS PRELIMINARES

    Directory of Open Access Journals (Sweden)

    DAMIÁN CÉSAR CASTRO

    2015-06-01

    Full Text Available O objetivo do trabalho foi avaliar o efeito da carga de frutos sobre a produção total, calibre, massa média, comprimento dos ramos e intensidade da frutificação no ano seguinte, em plantas de macieira (Malus × domesticaBorkh. cv. ‘Princesa’. Durante os anos de 2009 e 2010, as infrutescências foram submetidas a raleio manual, deixando nas árvores uma carga de 1 a 9 frutos por centímetro quadrado de superfície do tronco (FCQ. A produção total aumentou com o incremento da carga frutífera desde 1 a 9 FCQ, enquanto a massa média dos frutos diminuiu no mesmo intervalo. A quantidade de frutos pequenos aumentou até atingir 10% do total nas plantas de maior carga e a proporção de frutos de tamanho médio cresceu, alcançando 35% do total da produção. No entanto, a quantidade de frutos grandes não foi afetada pelo nível de carga, mantendo-se em maior proporção com relação ao total colhido (˜66%. O crescimento dos ramos, até 60 dias após a colheita, esteve negativamente afetado pela intensidade de carga. Observouse que não houve alternância de safra no ano seguinte ao experimento. A carga ótima para minimizar a produção de frutos pequenos, alcançando a maior produção total sem debilitar as árvores, pode-se atingir no intervalo entre 5 e 9 FCQ.

  5. Brief Report: A Family Risk Study Exploring Bipolar Spectrum Problems and Cognitive Biases in Adolescent Children of Bipolar Parents

    Science.gov (United States)

    Espie, Jonathan; Jones, Steven H.; Vance, Yvonne H.; Tai, Sara J.

    2012-01-01

    Children of parents with bipolar disorder are at increased risk of bipolar spectrum diagnoses. This cross-sectional study explores cognitive factors in the prediction of vulnerability to bipolar disorder. Adolescents at high-risk (with a parent with bipolar disorder; n = 23) and age and gender matched adolescents (n = 24) were recruited. Parent…

  6. Lower switch rate in depressed patients with bipolar II than bipolar I disorder treated adjunctively with second-generation antidepressants

    NARCIS (Netherlands)

    Altshuler, LL; Suppes, T; Nolen, WA; Leverich, G; Keck, PE; Frye, MA; Kupka, R; McElroy, SL; Grunze, H; Kitchen, CMR; Post, R; Black, D.O.

    Objectives: The authors compared the switch rate into hypomania/mania in depressed patients treated with second-generation antidepressants who had either bipolar I or bipolar II disorder. Method: In a 10-week trial, 184 outpatients with bipolar depression (134 with bipolar I disorder, 48 with

  7. Avaliação da carga mental de trabalho e do desempenho de medidas de mensuração: NASA TLX e SWAT

    OpenAIRE

    Cardoso,Mariane de Souza; Gontijo,Leila Amaral

    2012-01-01

    Este estudo avalia a carga mental para atividades desempenhadas em empresa catarinense de soluções em energia e busca comparar os resultados da carga mental de trabalho encontrada a partir de dois métodos de mensuração atualmente mais usados - NASA TLX e SWAT. Por meio deste estudo avaliou-se a carga mental exigida tanto pela atividade de montagem manual, quanto de montagem automática de placas eletrônicas. Os resultados da avaliação da carga mental evidenciaram que entre as duas formas de ex...

  8. Violence in schizophrenia and bipolar disorder.

    Science.gov (United States)

    Volavka, Jan

    2013-03-01

    Although most psychiatric patients are not violent, serious mental illness is associated with increased risk of violent behavior. Most of the evidence available pertains to schizophrenia and bipolar disorder. MEDLINE data base was searched for articles published between 1966 and November 2012 using the combination of key words 'schizophrenia' or 'bipolar disorder' with 'aggression' or 'violence'. For the treatment searches, generic names were used in combination with key words 'schizophrenia' or 'bipolar disorder' and 'aggression' No language constraint was applied. Only articles dealing with adults were included. The lists of references were searched manually to find additional articles. There were statistically significant increases of risk of violence in schizophrenia and in bipolar disorder in comparison with general population. The evidence suggests that the risk of violence is greater in bipolar disorder than in schizophrenia. Most of the violence in bipolar disorder occurs during the manic phase. The risk of violence in schizophrenia and bipolar disorder is increased by comorbid substance use disorder. Violence among adults with schizophrenia may follow at least two distinct pathways-one associated with antisocial conduct, and another associated with the acute psychopathology of schizophrenia. Clozapine is the most effective treatment of aggressive behavior in schizophrenia. Emerging evidence suggests that olanzapine may be the second line of treatment. Treatment adherence is of key importance. Non-pharmacological methods of treatment of aggression in schizophrenia and bipolar disorder are increasingly important. Cognitive behavioral approaches appear to be effective in cases where pharmacotherapy alone does not suffice. Violent behavior of patients with schizophrenia and bipolar disorder is a public health problem. Pharmacological and non-pharmacological approaches should be used to treat not only violent behavior, but also contributing comorbidities such

  9. Tratamento do transtorno bipolar: eutimia Bipolar disorder treatment: euthymia

    Directory of Open Access Journals (Sweden)

    Fábio Gomes de Matos e Souza

    2005-01-01

    Full Text Available O transtorno bipolar é um quadro complexo caracterizado por episódios de depressão, mania ou hipomania e fases assintomáticas. O tratamento visa ao controle de episódios agudos e prevenção de novos episódios. O tratamento farmacológico iniciou-se com o lítio. Até o momento, o lítio permanece como o tratamento com mais evidências favoráveis na fase de manutenção. Outros tratamentos demonstram eficácia nessa fase, como o valproato, a carbamazepina e os antipsicóticos atípicos. Dos antipsicóticos atípicos o mais estudado nesta fase do tratamento é a olanzapina. Mais estudos prospectivos são necessários para confirmar a ação profilática de novos agentes.Bipolar disorder is a complex disorder characterized by depression episodes, mania or hypomania and asymptomatic phases. The treatment aims at the control of acute episodes and prevention of new episodes. The pharmacological treatment was inaugurated with lithium. Until the moment, lithium remains as the treatment with more favorable evidences in the maintenance phase. Other treatments demonstrate efficacy in this phase, as valproate, carbamazepine and atypical antipsychotics. Of the atypical antipsychotics, the most studied in this phase of treatment is olanzapine. More prospective studies are necessary to confirm prophylactic action of new agents.

  10. ABEJAS VISITANTES DE Mimosa pigra L. (MIMOSACEAE:COMPORTAMIENTO DE PECOREO Y CARGAS POLÍNICAS

    Directory of Open Access Journals (Sweden)

    CLARA ISABEL AGUILAR SIERRA

    2009-01-01

    Full Text Available RESUMEN Se estudiaron las cargas polínicas de 13 taxones de abejas capturadas visitando a Mimosa pigra en la zona de influencia del Embalse Porce II (Antioquia, Colombia. De los 21 tipos polínicos encontrados, M. pigra presenta el mayor porcentaje acumulado de colecta; Mimosa pudica, Piper aduncum, Solanum diversifolium, Warszewiczia coccinea y Psidium guajava, en su orden, se pueden considerar fuentes alternativas de polen, para varias de las especies de abejas cuyas cargas polínicas fueron analizadas. Dentro de las especies de abejas capturadas visitando a M. pigra se pueden diferenciar varios grupos según el tipo y abundancia relativa de los tipos polínicos encontrados en sus cargas. Uno de ellos, incluye a siete especies de abejas con más del 85% de granos de polen de M. pigra; otro, con cuatro especies de abejas que colectaron más del 94,5% del polen en M. pigra y M. pudica. Adicionalmente, se encontraron especies como Trigona dorsalis con cargas de M. pigra (59,4%, de S. diversifolium (37,8% y especies de abejas como Lasioglossum sp. 113, en cuyas cargas polínicas predominan los granos de polen de P. aduncum (61,8% y de W.coccinea (36,4%, en contraste con los de M. pigra (1,3%. En cuanto a la riqueza de tipos polínicos colectados por las abejas sobresalen Trigona muzoensis (12 tipos polínicos y T. dorsalis (10 tipos, lo cual refleja nichos tróficos más amplios para estas especies y deja duda sobre su constancia floral o hábitos de limpieza. Palabras clave: Mimosa pigra, cargas polínicas, tipos polínicos, abejas, polinización. ABSTRACT We studied the pollen loads of 13 taxa of wild bees visiting the flowers of Mimosa pigra on the influence zone of the Dam Project Porce II (Antioquia, Colombia. Out of 21 different pollen types, M. pigra represents the higuest percentage; Mimosa pudica, Piper aduncum, Solanum diversifolium, Warszewiczia coccinea and Psidium guajava, in that order, were also abundant, and are alternative

  11. Carga mental en la mujer trabajadora: desigualdad de género y prevalencia

    Directory of Open Access Journals (Sweden)

    M.ª Carmen Fernández Felipe

    2015-03-01

    Full Text Available Introducción: La igualdad de género hay sido una preocupación introducida en los últimos años por instituciones tanto internacionales como nacionales. La cuestión de igualdad afecta también al ámbito laboral tanto en lo que se refiere a la distribución del trabajo como a la exposición a riesgos psicosociales, principalmente en economías basadas en la información y conocimiento. Los objetivos de este estudio se dirigen a identificar, entre la población trabajadora española, situaciones de desigualdad entre géneros en lo que se refiere a los diferentes componentes de la carga mental y estimar su prevalencia. Material y métodos: Se realizó un estudio observacional de tipo transversal a partir de los datos recogidos de la «VII Encuesta Nacional de Condiciones del Trabajo» con una muestra de 8.892 trabajadores. Los datos se analizaron de forma bivariante utilizándose el test de Chi-Cuadrado para las variables cualitativas y el t-test para muestras independientes en el caso de variables cuantitativas. La significación se consideró con p < 0,05. Con el objeto de analizar la influencia de distintos factores potencialmente relacionados con componentes de la carga mental y su interacción, se realizó un análisis de regresión logística binaria con el método de inclusión retroceder por paso (Wald. Resultados: Los hombres manifiestan sufrir una menor carga mental que la mujer en relación con el ritmo de trabajo, OR = 0,89 (0,8-0.9, la prevalencia de un «Alto ritmo de trabajo» fue de (0,65‰ en mujeres con respecto a un 0,63‰ en hombres. Los hombres refirieron una menor carga mental por «exceso de trabajo» con respecto a las mujeres OR = 0,9 (0,8-1,0. Las mujeres con mayor frecuencia que el hombre se encuentran fatigadas por una sobrecarga de trabajo (0,37‰ 0,35‰ respectivamente. Conclusiones: Estos resultados no corroboran nuestra hipótesis inicial de que la mujer está expuesta a una mayor carga mental que el hombre

  12. Ionizing radiations simulation on bipolar components

    International Nuclear Information System (INIS)

    Montagner, X.

    1999-01-01

    This thesis presents the ionizing radiation effects on bipolar components and more specially their behavior facing the total dose. The first part is devoted to the radiation environments with a special attention to the spatial environments and new emergent environments. The specificities of bipolar components are then presented and their behavior facing the interactions. The physical mechanisms bound to the dose rate are also discussed. The second part presents a physical analysis of degradations induced by the cumulated dosimetry on bipolar components and simulation with the ATLAS code. The third part exposes an electric empirical simulation induced by the cumulated dose in static conditions. (A.L.B.)

  13. Bipolar Disorder and Early Affective Trauma.

    Science.gov (United States)

    de Codt, Aloise; Monhonval, Pauline; Bongaerts, Xavier; Belkacemi, Ikram; Tecco, Juan Martin

    2016-09-01

    Bipolar disorder is a chronic psychiatric disease with a high prevalence and is a major psychosocial and medical burden. The exact etiological pathways of bipolar disorder are not fully understood. Genetic factors are known to play an important role in the etiology of bipolar disorder. However, high rates of discordance among identical twins and a growing body of evidence that environmental factors such as early stress can influence the onset and course of psychiatric diseases underline the importance of additional etiological mechanisms of bipolar disorders. There has been little investigation about early trauma in bipolar disorder. The aim of this study was to review the literature on the association between early traumatic interactions like child neglect, mistreatment, abuse or early parental separation and the occurrence of bipolar disorder in adulthood or impact on the course of the disease. Studies investigating associations between child neglect, mistreatment, abuse or early parental separation and occurrence of bipolar disorder in adulthood or impact on the course of the disease were searched in the Pubmed database. More than 700 articles were sorted independently by two of the authors using predefined criteria. Only research articles, reviews and meta-analyses were selected for this review. 53 articles met the inclusion criteria. To date, four systematic reviews partially addressed our research question. Early trauma is more frequently found in the past of bipolar patients than in the general population. Studies support a harmful effect of childhood trauma on the course of bipolar disease, with more anxious, depressive or psychotic symptoms, an early age of onset and a worse prognosis. Early trauma is more often found in the past of bipolar adult patients than the general population and studies support a harmful effect of childhood trauma on the course of bipolar disease, with more anxious, depressive or psychotic symptoms, an early age of onset and a

  14. Cognitive Behavioral Therapy in Bipolar Disorder

    Directory of Open Access Journals (Sweden)

    Zeynep Mackali

    2011-12-01

    Full Text Available Bipolar disorder is an early-onset, chronic disorder. It impairs occupational, social, and family functioning, which makes learning to adapt living with the disorder and its treatment critically important. Therefore, it has now become common knowledge that psychosocial interventions are also necessary in the treatment of bipolar disorder adjunctive to pharmacotherapy. Thus, whichever psychosocial interventions are more effective in bipolar disorder is a crucial research question. In this article, cognitive-behavioral therapy, which is applied adjunctive to pharmacotherapy, will be addressed and the findings of research about the effectiveness of these applications will be reviewed.

  15. Sexuality and Sexual Dysfunctions in Bipolar Disorder

    Directory of Open Access Journals (Sweden)

    Zeynep Namli

    2016-12-01

    Full Text Available In the clinical course of bipolar disorder, there is a reduction in sexual will during depressive episodes and inappopriate sexual experiences and hypersexuality occurs during manic episodes. Up to now, studies focused on sexual side effects of drugs. Sexual violence, sexually transmitted diseases, contraception methods, unplanned pregnancies need to be assessed carefully in bipolar disorder patients. This review focused on sexuality and sexual dysfunctions in the course of bipolar disorder. [Psikiyatride Guncel Yaklasimlar - Current Approaches in Psychiatry 2016; 8(4.000: 309-320

  16. Función del diafragma durante la colocación de cargas sobre el abdomen en sujetos normales

    Directory of Open Access Journals (Sweden)

    Sergio G. Monteiro

    2012-04-01

    Full Text Available Los efectos de las cargas en el abdomen con el objeto de producir entrenamiento del diafragma, no han sido suficientemente evaluados. Estudiamos la función del diafragma durante la colocación de cargas sobre el abdomen y con cambios en el patrón respiratorio. Se estudiaron 6 voluntarios normales. Se obtuvo flujo en la boca, presión gástrica (Pga, presión esofágica (Pes, movimiento torácico (TX y abdominal (AB, presión inspiratoria máxima (PImax y presión transdiafragmática media (Pdi y máxima (Pdimax. Se calculó la relación Pdi/Pdimax y el índice tensión-tiempo del diafragma (TTdi. Etapas: patrón normal (PN, patrón abdominal (PA y carga de 1, 2, 4 y 6 kg con PN y PA. El PA fue facilitado por las cargas sobre el abdomen. Solo con 6 kg (PN y PA la Pga a capacidad residual funcional aumentó significativamente (p 0.001. La Pdi siguió a las variaciones de la Pga y aumentó con todos los PA (p < 0.001. Con PA y carga el índice TTdi alcanzó un valor de 0.05 ± 0.02 (p < 0.001. Las cargas no aumentaron este índice más de lo que hizo el PA solo. Nuestros hallazgos sugieren que las cargas sobre el abdomen aumentan la propiocepción relacionada con los movimientos respiratorios y descenso del diafragma. Las cargas producen cambios leves en la mecánica del diafragma (en sujetos normales, 1/3 de la carga necesaria para desarrollar fatiga. En sujetos normales estos cambios parecen ser insuficientes para producir entrenamiento de los músculos respiratorios.

  17. Progression along the Bipolar Spectrum: A Longitudinal Study of Predictors of Conversion from Bipolar Spectrum Conditions to Bipolar I and II Disorders

    Science.gov (United States)

    Alloy, Lauren B.; Urošević, Snežana; Abramson, Lyn Y.; Jager-Hyman, Shari; Nusslock, Robin; Whitehouse, Wayne G.; Hogan, Michael

    2011-01-01

    Little longitudinal research has examined progression to more severe bipolar disorders in individuals with “soft” bipolar spectrum conditions. We examine rates and predictors of progression to bipolar I and II diagnoses in a non-patient sample of college-age participants (n = 201) with high General Behavior Inventory scores and childhood or adolescent onset of “soft” bipolar spectrum disorders followed longitudinally for 4.5 years from the Longitudinal Investigation of Bipolar Spectrum (LIBS) project. Of 57 individuals with initial cyclothymia or bipolar disorder not otherwise specified (BiNOS) diagnoses, 42.1% progressed to a bipolar II diagnosis and 10.5% progressed to a bipolar I diagnosis. Of 144 individuals with initial bipolar II diagnoses, 17.4% progressed to a bipolar I diagnosis. Consistent with hypotheses derived from the clinical literature and the Behavioral Approach System (BAS) model of bipolar disorder, and controlling for relevant variables (length of follow-up, initial depressive and hypomanic symptoms, treatment-seeking, and family history), high BAS sensitivity (especially BAS Fun Seeking) predicted a greater likelihood of progression to bipolar II disorder, whereas early age of onset and high impulsivity predicted a greater likelihood of progression to bipolar I (high BAS sensitivity and Fun-Seeking also predicted progression to bipolar I when family history was not controlled). The interaction of high BAS and high Behavioral Inhibition System (BIS) sensitivities also predicted greater likelihood of progression to bipolar I. We discuss implications of the findings for the bipolar spectrum concept, the BAS model of bipolar disorder, and early intervention efforts. PMID:21668080

  18. Reforma de edificios antiguos. El rasgado de huecos en muros de carga

    Directory of Open Access Journals (Sweden)

    Soto Pardo, M.

    1985-10-01

    Full Text Available Forming openings in load-bearing brickwork is a very frequent operation when reforming old buildings. A correct solution requires the supporting structure, usually a steel portal frame, to be loaded by means of hydraulic jacks or some similar system. This step is normally omitted which gives rise to two different problems. Fistly, a delayed loosening of the unsupported area occurs and alarming cracks appear. Secondly and much more dangerous though not so apparent, is the overloading of certain areas of brickwork which can result in collapse due to bearing failure. This article considers the loading sequence for correctly opening up the brickwork. It a/so provides an original in situ method for estimating brickwork strengths as a complement to a visual inspection.La apertura de huecos en muros de carga es una operación frecuente en la reforma de edificios antiguos. Una correcta ejecución exige la puesta en carga de la estructura sustentante —normalmente un pórtico metálico— mediante gatos hidráulicos o algo similar, cosa que suele omitirse, dando lugar a dos problemas diferentes: uno, el desprendimiento diferido del área de descarga, con alarmantes fisuraciones y otro, sin efectos ostensibles, pero mucho más peligroso, como es la sobrecarga elevadísima en ciertas zonas de la fábrica que puede desembocar en un colapso por aplastamiento. Este artículo estudia y calcula la puesta en carga para una correcta ejecución del rasgado. También se ofrece un método, original, de estimación de calidades resistentes de las fábricas de ladrillo a rasgar, efectuando "in situ", que complementa las apreciaciones visuales.

  19. Capacidad de carga estática en rodamientos. Normalización y tendencias.

    Directory of Open Access Journals (Sweden)

    A. García Toll

    2007-01-01

    Full Text Available Para ilustrar la funcionalidad de la norma NC-ISO 76: 2006, establecida a partir de una adopción idéntica de la Norma ISO 76: 1987/ amd.1: 1999 (E “Cojinetes de Rodamiento – Capacidad de Carga Estática”, son mostradas las correspondencias entre las magnitudes de capacidad de carga estática declaradas en los catálogos técnicos de reconocidos fabricantes de rodamientos con los valores presentes en NC-ISO 76 y considerando diferentes geometrías de rodamientos radiales de bolas rígidos y de contacto angular, rodamientos axiales de bolas y rodamientos de rodillos cilíndricos. Adicionalmente, el estudio ha permitido establecer las dependencias entre la capacidad de carga nominal estática del rodamiento y algunos parámetros geométricos, como el diámetro del elemento rodante, el diámetro interior y la relación diámetro interior - diámetro exterior del cojinete.At the present time, Standard NC-ISO 76: 2006 is a national standard established as identical adoption of ISO standard 76:1987 / amd.1: 1999 (E "Rolling Bearings - Static Load Rating¨. In this sense, the static load rating of rolling bearings declared in technical catalogs of renowned bearing manufacturers and the basic static load rating according to calculation procedures stated in Standard NC-ISO 76 are compared. The evaluation has taken into account different geometries of radial groove ball bearings, angular contact ball bearings, thrust ball bearings and radial roller bearings. Additionally, they are established dependences between the static load rating of rolling bearings and the interior diameter of different types of radial and thrust bearings.

  20. Monitoramento da carga interna de um período de treinamento em jogadores de voleibol

    Directory of Open Access Journals (Sweden)

    Victor Hugo de FREITAS

    2015-03-01

    Full Text Available O objetivo desse estudo foi monitorar e analisar a dinâmica da carga interna, a partir do método da Percepção Subjetiva de Esforço da sessão (PSE-sessão, durante um período de treinamento no voleibol. Doze jogadores de uma equipe de voleibol (23,5 ± 3,4 anos, 88,2 ± 11,4 kg, 190,4 ± 10,8 cm foram monitorados durante 22 semanas de treinamento divididas em cinco mesociclos. A ANOVA revelou haver diferenças significativas nos valores de carga de treinamento semanal total (CTST, monotonia e "strain" entre os mesociclos (p < 0,05. A CTST do mesociclo 1 foi menor quando comparada aos mesociclos 2, 4 e 5. Os valores de monotonia foram baixos, com valores inferiores a 1,4 ± 0,1 UA. O coeficiente de variação da média da CTST das 22 semanas foi de 16%. O valor médio da média da CTST das 22 semanas foi de 1790,9 UA. O menor valor de média da CTST das 22 semanas foi de 1324,3 UA e o maior valor foi de 2232,7 UA. Desse modo, a carga interna de treinamento apresentou momentos de maior e menor magnitude entre as semanas, e aumentou do primeiro para o segundo mesociclo com manutenção das mesmas nos mesociclos seguintes.

  1. Alteraciones emocionales y la relación con las cargas de entrenamiento en nadadores de alto rendimiento

    Directory of Open Access Journals (Sweden)

    Maria Regina Ferreira Brandão

    2015-12-01

    Full Text Available Resumen El objetivo de este estudio fue evaluar la relación entre la carga de entrenamiento y el estado de ánimo durante un macrociclo. Veinte nadadores velocistas de alto rendimiento, de ambos sexos fueron evaluados a través de la Escala de Percepción Subjetiva del Esfuerzo (PSE y el perfil Brums. La carga de entrenamiento se determina multiplicando kilómetros nadó (volumen semanalmente por la respuesta del PSE semanal. La correlación de Pearson fue usada para verificar la relación entre la carga de entrenamiento y el estado de ánimo. Los resultados mostraron una correlación positiva entre la carga y la fatiga, y negativa con el vigor (p < 0,01. Por lo tanto, se concluyó que la carga de entrenamiento determinada por la relación entre el volumen y la PSE está relacionada com los estados emocionales, el vigor y la fatiga.

  2. Algoritmo para el cálculo de cargas de trabajo

    OpenAIRE

    Mauricio Becerra Fernández; Stefany Ayala Lozano; Jenny Alexandra Astros Hernández; Elsa Cristina González La Rotta

    2016-01-01

    Este artículo presenta el desarrollo un algoritmo para el cálculo de cargas de trabajo, soportado en el análisis de estudios similares y la teoría del estudio de métodos y tiempos. El algoritmo se propone como un elemento de soporte para el análisis del nivel trabajo asignado a un cargo específico o a un grupo de trabajadores en un área determinada, ya sea en la industria de manufactura o de servicios, lo que permita nivelar el volumen de trabajo asignado mediante la definición de diversas al...

  3. El trabajo en equipo en el Proceso Administrativo y de Compras en OPL Carga de Bucaramanga

    OpenAIRE

    Silva Remolina, Maria Andrea

    2014-01-01

    El proceso administrativo y de compras de OPL Carga tiene algunas falencias entre ellas: fallas en la Comunicación entre el personal operativo, no se realizan llamadas internas usando con frecuencia el email, produciendo la saturación de solicitudes las cuales terminan sin ser resueltas en cuanto a roles se refiere, no hay enfoque de procesos en vista que no se tiene claras las tareas de cada cargo, adicionalmente no hay claridad en los subprocesos, perjudicando el proceso con el a...

  4. Capacidade de Carga Turística: Um Estudo no Caminhos Rurais de Porto Alegre, RS

    Directory of Open Access Journals (Sweden)

    Juliane Magagnin Da Soller

    2013-10-01

    Full Text Available Nesse artigo, apresenta-se o contexto do turismo de base comunitária, além de breve histórico e discussão acerca do conceito e da metodologia da Capacidade de Carga Turística, assim como a adaptação da metodologia para estudo aqui relatado. Descreve-se o estudo realizado para determinar a Capacidade de Carga Turística, tendo por amostra as propriedades rurais partícipes da Associação Porto Alegre Rural (POA RURAL, mais especialmente do roteiro Caminhos Rurais de Porto Alegre, no estado do Rio Grande do Sul. Propôs-se adaptar a para o local a metodologia de cálculo de Capacidade de Carga Turística a partir de Cifuentes (1992; et al 1996, considerando suas particularidades, principalmente aquelas que dizem respeito a saúde e ao bem-estar das famílias que recebem os visitantes e aos impactos ambientais causados pelas construções de infraestrutura turística. A Capacidade de Carga Turística é uma metodologia desenvolvida para áreas preservadas de uso público. Assim, não costuma dar enfoque às questões referentes à comunidade local e aos resíduos gerados pelas instalações e pelos serviços prestados no Turismo.  Tourist Carrying Capacity: A study in the Caminhos Rurais de Porto Alegre, RS  - This paper presents the community based tourism and a brief history, concept and methodology of Tourist Carrying Capacity, and the adaptation of that methodology to the present case. The paper presents the study to determine the Tourist Carrying Capacity in rural proprieties that currently constitute the Porto Alegre Rural Association (RURAL POA, the tourist destination Caminhos Rurais de Porto Alegre, Rio Grande do Sul. The research proposes to adapt the methodology of Tourist Carrying Capacity from Cifuentes (1992, et al 1996, to the Caminhos Rurais, considering its particularities, especially those relate to health and well-being of families who receives visitors, and the environmental impacts caused by the construction of

  5. Comportamiento de viviendas de ferrocemento bajo cargas cíclicas

    OpenAIRE

    Bedoya Ruiz, Daniel; Álvarez Betancur, David

    2009-01-01

    La escasez de vivienda en el mundo ha llevado desde hace varios años a la búsqueda de nuevos materiales y sistemas alternativos para su construcción. El ferrocemento desde hace más de 25 décadas viene siendo estudiado y aplicado como solución de vivienda en varios países; Colombia, uno de ellos. En este trabajo se presenta parte de los resultados de una investigación acerca del comportamiento de las viviendas de ferrocemento bajo cargas cíclicas. Se probaron dos módulos de vivienda a es...

  6. El impacto de los costos en el transporte de carga pesada en la modalidad volquetes

    OpenAIRE

    Balarezo Torres, María Luisa

    2015-01-01

    Esta investigación tiene como objetivo establecer una Estructura de Costos Operativos eficiente, aplicado al segmento del transporte de Carga Pesada, modalidad volquetes, así como también estimar el impacto de los costos estándar para Volquetes en los años 2010 - 2013, en la provincia del Azuay, cantón Cuenca. El trabajo de investigación está basado en la experiencia y manejo de una empresa de transporte pesado, durante 5 años, encuestas al sector y análisis de los elementos fijos y variables...

  7. PERIODIZAÇÃO E EVOLUÇÃO DA LOGÍSTICA URBANA DE CARGAS

    OpenAIRE

    Fander de Oliveira Silva; William Rodrigues Ferreira

    2017-01-01

    PERIODIZATION AND EVOLUTION OF URBAN LOGISTICS OF LOADS PERIODIZACIÓN Y EVOLUCIÓN DE LA LOGÍSTICA URBANA DE CARGAS A Logística tem apresentado uma contínua evolução no espaço urbano e no seu conceito funcional. Ao longo do seu desenvolvimento chegou a ser considerada um dos principais pontos estratégicos do sistema de produção integrado, incorporando inovações e gerando outras de acordo com o atual conceito de Gerenciamento de Cadeia de Suprimentos. O objetivo principal deste trabalho...

  8. Carga mental y fatiga en servicios especiales de enfermería

    OpenAIRE

    José Luis González Gutiérrez; Bernardo Moreno Jiménez; Eva Garrosa Hernández; Almudena López López

    2005-01-01

    El trabajo explora la asociación entre algunos de los factores laborales y demográficos más relevantes (sexo, edad, nivel profesional, años de experiencia en la profesión, servicio de atención, turno, duración de la jornada laboral, número de pacientes que atiende al día y situación laboral) y el nivel de carga mental y de fatiga laboral en una muestra de 228 profesionales de enfermería que desarrollaban su actividad en ocho servicios especiales de atención. Para cada una de la...

  9. Caracterização da carga de treinamento no voleibol de alto rendimento

    OpenAIRE

    Horta, Thiago Andrade Goulart

    2014-01-01

    A quantificação e a distribuição adequada das cargas de treinamento, somados a análise de marcadores de estresse e rendimento envolvidos no processo de treinamento, são fundamentais para que ocorram as adaptações psicofisiológicas específicas e o aumento de rendimento dos atletas. Dessa forma, o presente estudo teve os seguintes objetivos 1) analisar o comportamento das variáveis bioquímicas, psicológicas e de rendimento em quatro momentos do período preparatório de treinamento; 2) analisar o...

  10. Estudos farmacoeconômicos e carga da doença em esquizofrenia

    OpenAIRE

    Daltio,Claudiane Salles; Mari,Jair de Jesus; Ferraz,Marcos Bosi

    2007-01-01

    CONTEXTO: A preocupação com a saúde e os benefícios das terapêuticas ao paciente continua sendo o foco da medicina, mas conhecer os custos envolvidos e fazer a gestão dos recursos disponíveis é fundamental na atualidade. OBJETIVO: Este artigo pretende fazer uma revisão sobre alguns conceitos utilizados nos estudos farmacoeconômicos, tais como tipos de custos (diretos, indiretos, intangíveis), tipos de análises econômicas e carga de doença na esquizofrenia. MÉTODO: Foi realizada uma revisão na...

  11. Carga inmediata con implantes en maxilar superior Immediate loading of implants in the maxilla

    OpenAIRE

    F. Monje Gil; C. Moreno García; H. Serrano Gil; O. Maestre; A.J. Morillo Sánchez; J. Mateo Arias; L. Ruiz Laza; P. Quiros Álvarez; D. Manzano Solo de Zaldivar

    2007-01-01

    La carga inmediata en la mandíbula se ha incorporado a la práctica clínica en primer lugar y, por las características del hueso, se realiza de forma protocolizada. Sin embargo, en el maxilar superior no hay evidencia científica para realizarlo de forma cotidiana. Las razones son debidas a que el maxilar superior, en general, alberga una masa ósea de menor densidad. Por otro lado, en el maxilar superior pueden coexistir diferentes densidades óseas (según la clasificación de Misch) en el mismo ...

  12. The effectiveness of cognitive behavioral group therapy in treating bipolar disorder: a randomized controlled study A eficácia da terapia cognitivo-comportamental para o tratamento do transtorno bipolar: um estudo controlado e randomizado

    Directory of Open Access Journals (Sweden)

    Rafael Thomaz da Costa

    2011-01-01

    Full Text Available OBJECTIVE: Recent studies suggest that, when combined with pharmacotherapy, structured psychotherapy may modify the course of bipolar disorder. However, there are few studies that have examined the effects of cognitive behavioral group therapy on the course of this disorder. The aim of the present study was to evaluate the effectiveness of 14 sessions of cognitive behavioral group therapy, combined with pharmacotherapy, on the treatment of patients with bipolar disorder, and to compare our results against those from the use of pharmacotherapy alone. METHOD: Forty-one patients with bipolar I and II disorder participated in the study and were randomly allocated to one of two treatment groups; thirty-seven patients remained in the study until its completion. Mood and anxiety symptoms were measured in all subjects. Statistical analysis was used to investigate if the groups differed with respect to demographic characteristics and the scores recorded in the pre- and post-treatment stages, as well as during treatment (intra/inter groups. RESULTS: Patients showed statistically similar population characteristics. The association of cognitive behavioral group therapy and pharmacological treatment proved to be effective. Patients who had undergone cognitive behavioral group therapy presented fewer symptoms of mania, depression and anxiety, as well as fewer and shorter mood change episodes. CONCLUSION: Cognitive behavioral group therapy sessions substantially contributed to the improvement of depression symptoms.OBJETIVO: Estudos recentes sugerem que uma psicoterapia estruturada aplicada junto com a farmacoterapia pode alterar o curso do transtorno afetivo bipolar. Entretanto, poucos estudos investigam os resultados da terapia cognitivo-comportamental em grupo sobre este transtorno psiquiátrico. O objetivo desta pesquisa foi avaliar a eficácia de 14 sessões de terapia cognitivo-comportamental em grupo concomitante à farmacoterapia para bipolares e

  13. The effectiveness of cognitive behavioral group therapy in treating bipolar disorder: a randomized controlled study A eficácia da terapia cognitivo-comportamental para o tratamento do transtorno bipolar: um estudo controlado e randomizado

    Directory of Open Access Journals (Sweden)

    Rafael Thomaz da Costa

    2011-06-01

    Full Text Available OBJECTIVE: Recent studies suggest that, when combined with pharmacotherapy, structured psychotherapy may modify the course of bipolar disorder. However, there are few studies that have examined the effects of cognitive behavioral group therapy on the course of this disorder. The aim of the present study was to evaluate the effectiveness of 14 sessions of cognitive behavioral group therapy, combined with pharmacotherapy, on the treatment of patients with bipolar disorder, and to compare our results against those from the use of pharmacotherapy alone. METHOD: Forty-one patients with bipolar I and II disorder participated in the study and were randomly allocated to one of two treatment groups; thirty-seven patients remained in the study until its completion. Mood and anxiety symptoms were measured in all subjects. Statistical analysis was used to investigate if the groups differed with respect to demographic characteristics and the scores recorded in the pre- and post-treatment stages, as well as during treatment (intra/inter groups. RESULTS: Patients showed statistically similar population characteristics. The association of cognitive behavioral group therapy and pharmacological treatment proved to be effective. Patients who had undergone cognitive behavioral group therapy presented fewer symptoms of mania, depression and anxiety, as well as fewer and shorter mood change episodes. CONCLUSION: Cognitive behavioral group therapy sessions substantially contributed to the improvement of depression symptoms.OBJETIVO: Estudos recentes sugerem que uma psicoterapia estruturada aplicada junto com a farmacoterapia pode alterar o curso do transtorno afetivo bipolar. Entretanto, poucos estudos investigam os resultados da terapia cognitivo-comportamental em grupo sobre este transtorno psiquiátrico. O objetivo desta pesquisa foi avaliar a eficácia de 14 sessões de terapia cognitivo-comportamental em grupo concomitante à farmacoterapia para bipolares e

  14. Análise da aceitação de aguardentes de cana por testes afetivos e mapa de preferência interno

    Directory of Open Access Journals (Sweden)

    CARDELLO Helena Maria André Bolini

    2000-01-01

    Full Text Available A aceitação de 11 amostras de aguardentes de cana envelhecidas e não envelhecidas foi avaliada por testes sensoriais afetivos e análises estatísticas uni e multivariada. As aguardentes estudadas compreenderam seis amostras comerciais de diferentes marcas, (sendo três não envelhecidas e três envelhecidas e ainda outras cinco amostras correspondentes a zero, 12, 24, 36 e 48 meses de envelhecimento em um tonel de carvalho de 200L. As amostras foram avaliadas por 100 provadores consumidores do produto, recrutados por questionário de avaliação quanto à afetividade. Para os testes afetivos foi utilizada escala hedônica não estruturada de 9cm, sendo os dados obtidos avaliados por dois métodos estatísticos distintos: o Mapa de Preferência Interno (MDPREF e a análise de variância univariada (ANOVA com comparação de médias pelo teste de Tukey e análise de correlação. As amostras de aguardente envelhecidas por 12, 36 e 48 meses obtiveram maior aceitação, com médias ao redor de 7,0 na escala hedônica. A amostra com menor aceitação foi a correspondente ao tempo zero de envelhecimento (controle. As demais amostras obtiveram aceitação intermediária. A análise por MDPREF gerou em espaço multidimensional (onde as variações com relação aos dados de preferência foram extraídas em eixos ortogonais e para cada dimensão de preferência, coordenadas relativas aos produtos, que foram geradas em função da resposta dos consumidores. Os dados de aceitação de cada provador foram utilizados para o desenvolvimento de vetores individuais de preferência, resultando na construção de um mapa mutidimensional das amostras, em função dos dados de aceitação. No presente estudo o MDPREF foi gerado pelas primeira e segunda dimensões de preferência, as quais explicaram em conjunto 89,83% das variações observadas entre as amostras com relação à aceitação. O MDPREF confirmou os resultados da ANOVA, indicando uma maior prefer

  15. Bipolar Electrode Sample Preparation Devices

    Science.gov (United States)

    Wang, Yi (Inventor); Song, Hongjun (Inventor); Pant, Kapil (Inventor)

    2017-01-01

    An analyte selection device can include: a body defining a fluid channel having a channel inlet and channel outlet; a bipolar electrode (BPE) between the inlet and outlet; one of an anode or cathode electrically coupled with the BPE on a channel inlet side of the BPE and the other of the anode or cathode electrically coupled with the BPE on a channel outlet side of the BPE; and an electronic system operably coupled with the anode and cathode so as to polarize the BPE. The fluid channel can have any shape or dimension. The channel inlet and channel outlet can be longitudinal or lateral with respect to the longitudinal axis of the channel. The BPE can be any metallic member, such as a flat plate on a wall or mesh as a barrier BPE. The anode and cathode can be located at a position that polarizes the BPE.

  16. Composite substrate for bipolar electrodes

    Science.gov (United States)

    Tekkanat, Bora; Bolstad, James J.

    1992-12-22

    Substrates for electrode systems, particularly those to be used for bipolar electrodes in zinc-bromine batteries, are disclosed. The substrates preferably include carbon-black as a conductive filler in a polymeric matrix, with reinforcing materials such as glass fibers. Warpage of the zinc-bromine electrodes which was experienced in the prior art and which was believed to be caused by physical expansion of the electrodes due to bromine absorption by the carbon-black, is substantially eliminated when new substrate fabrication techniques are employed. In the pesent invention, substrates are prepared using a lamination process known as glass mat reinforced thermoplastics technology or, in an alternate embodiment, the substrate is made using a slurry process.

  17. Bipolar disorder and neurophysiologic mechanisms

    Directory of Open Access Journals (Sweden)

    Simon M McCrea

    2008-11-01

    Full Text Available Simon M McCreaDepartments of Neurology and Neuroophthalmology, University of British Columbia, 2550 Willow Street, Vancouver, British Columbia, Canada V5Z 3N9Abstract: Recent studies have suggested that some variants of bipolar disorder (BD may be due to hyperconnectivity between orbitofrontal (OFC and temporal pole (TP structures in the dominant hemisphere. Some initial MRI studies noticed that there were corpus callosum abnormalities within specific regional areas and it was hypothesized that developmentally this could result in functional or effective connectivity changes within the orbitofrontal-basal ganglia-thalamocortical circuits. Recent diffusion tensor imaging (DTI white matter fiber tractography studies may well be superior to region of interest (ROI DTI in understanding BD. A “ventral semantic stream” has been discovered connecting the TP and OFC through the uncinate and inferior longitudinal fasciculi and the elusive TP is known to be involved in theory of mind and complex narrative understanding tasks. The OFC is involved in abstract valuation in goal and sub-goal structures and the TP may be critical in binding semantic memory with person–emotion linkages associated with narrative. BD patients have relative attenuation of performance on visuoconstructional praxis consistent with an atypical localization of cognitive functions. Multiple lines of evidence suggest that some BD alleles are being selected for which could explain the enhanced creativity in higher-ability probands. Associations between ROI’s that are not normally connected could explain the higher incidence of artistic aptitude, writing ability, and scientific achievements among some mood disorder subjects.Keywords: bipolar disorder, diffusion tensor imaging, white matter tractography, inferior longitudinal fasciculus, inferior fronto-occipital fasciculus, uncinate fasciculus, mood dysphoria, creativity, ventral semantic stream, writing ability, artistic aptitude

  18. Climatic factors and bipolar affective disorder

    DEFF Research Database (Denmark)

    Christensen, Ellen Margrethe; Larsen, Jens Knud; Gjerris, Annette

    2008-01-01

    In bipolar disorder, the factors provoking a new episode are unknown. As a seasonal variation has been noticed, it has been suggested that weather conditions may play a role. The aim of the study was to elucidate whether meteorological parameters influence the development of new bipolar phases....... A group of patients with at least three previous hospitalizations for bipolar disorder was examined every 3 months for up to 3 years. At each examination an evaluation of the affective phase was made according to the Hamilton Depression Scale (HAM-D(17)), and the Bech-Rafaelsen Mania Rating Scale (MAS......). In the same period, daily recordings from the Danish Meteorological Institute were received. We found no correlations between onset of bipolar episodes [defined as MAS score of 11 or more (mania) and as HAM-D(17) score of 12 or more (depression)] and any meteorological parameters. We found a statistical...

  19. Gene environment interactions in bipolar disorder.

    Science.gov (United States)

    Pregelj, Peter

    2011-09-01

    It has been estimated that the heritable component of bipolar disorder ranges between 80 and 90%. However, even genome-wide association studies explain only a fraction of phenotypic variability not resolving the problem of "lost heritability". Although direct evidence for epigenetic dysfunction in bipolar disorder is still limited, methodological technologies in epigenomic profiling have advanced, offering even single cell analysing and resolving the problem of cell heterogeneity in epigenetics research. Gene overlapping with other mental disorders represents another problem in identifying potential susceptibility genes in bipolar disorder. Better understanding of the interplay between multiple environmental and genetic factors involved in the patogenesis of bipolar disorder could provide relevant information for treatment of patients with this complex disorder. Future studies on the role of these factors in psychopathological conditions, subphenotypes and endophenotypes may greatly benefit by using more precise clinical data and a combined approach with multiple research tools incorporated into a single study.

  20. Are rates of pediatric bipolar disorder increasing?

    DEFF Research Database (Denmark)

    Kessing, Lars Vedel; Vradi, Eleni; Andersen, Per Kragh

    2014-01-01

    Studies from the USA suggest that rates of pediatric bipolar disorder have increased since the mid-90s, but no study outside the USA has been published on the rates of pediatric bipolar disorder. Further, it is unclear whether an increase in rates reflects a true increase in the illness or more...... diagnostic attention. Using nationwide registers of all inpatients and outpatients contacts to all psychiatric hospitals in Denmark, we investigated (1) gender-specific rates of incident pediatric mania/bipolar disorder during a period from 1995 to 2012, (2) whether age and other characteristics...... for pediatric mania/bipolar disorder changed during the calendar period (1995 to 2003 versus 2004 to 2012), and (3) whether the diagnosis is more often made at first psychiatric contact in recent time compared to earlier according to gender. Totally, 346 patients got a main diagnosis of a manic episode (F30...

  1. Internet use by patients with bipolar disorder

    DEFF Research Database (Denmark)

    Bauer, Rita; Conell, Jörn; Glenn, Tasha

    2016-01-01

    There is considerable international interest in online education of patients with bipolar disorder, yet little understanding of how patients use the Internet and other sources to seek information. 1171 patients with a diagnosis of bipolar disorder in 17 countries completed a paper-based, anonymous...... survey. 81% of the patients used the Internet, a percentage similar to the general public. Older age, less education, and challenges in country telecommunications infrastructure and demographics decreased the odds of using the Internet. About 78% of the Internet users looked online for information...... for information on bipolar disorder consulted medical professionals plus a mean of 2.3 other information sources such as books, physician handouts, and others with bipolar disorder. Patients not using the Internet consulted medical professionals plus a mean of 1.6 other information sources. The percentage...

  2. Thyroid Functions and Bipolar Affective Disorder

    OpenAIRE

    Chakrabarti, Subho

    2011-01-01

    Accumulating evidence suggests that hypothalamo-pituitary-thyroid (HPT) axis dysfunction is relevant to the pathophysiology and clinical course of bipolar affective disorder. Hypothyroidism, either overt or more commonly subclinical, appears to the commonest abnormality found in bipolar disorder. The prevalence of thyroid dysfunction is also likely to be greater among patients with rapid cycling and other refractory forms of the disorder. Lithium-treatment has potent antithyroid effects and c...

  3. Biological dysrhythm in remitted bipolar I disorder.

    Science.gov (United States)

    Iyer, Aishwarya; Palaniappan, Pradeep

    2017-12-01

    Recent treatment guidelines support treatment of biological rhythm abnormalities as a part of treatment of bipolar disorder, but still, literature examining various domains (Sleep, Activity, Social, and Eating) of biological rhythm and its clinical predictors are less. The main aim of our study is to compare various domains of biological rhythm among remitted bipolar I subjects and healthy controls. We also explored for any association between clinical variables and biological rhythm among bipolar subjects. 40 subjects with Bipolar I disorder and 40 healthy controls who met inclusion and exclusion criteria were recruited for the study. Diagnoses were ascertained by a qualified psychiatrist using MINI 5.0. Sociodemographic details, biological rhythm (BRIAN-Biological Rhythm Interview of assessment in Neuropsychiatry) and Sleep functioning (PSQI- Pittsburgh Sleep Quality Index) were assessed in all subjects. Mean age of the Bipolar subjects and controls were 41.25±11.84years and 38.25±11.25 years respectively. Bipolar subjects experienced more biological rhythm disturbance when compared to healthy controls (total BRIAN score being 34.25±9.36 vs 28.2±6.53) (p=0.002). Subsyndromal depressive symptoms (HDRS) had significant positive correlation with BRIAN global scores(r=0.368, p=0.02). Linear regression analysis showed that number of episodes which required hospitalization (β=0.601, t=3.106, P=0.004), PSQI (β=0.394, t=2.609, p=0.014), HDRS (β=0.376, t=2.34, t=0.036) explained 31% of variance in BRIAN scores in remitted bipolar subjects. Biological rhythm disturbances seem to persist even after clinical remission of bipolar illness. More studies to look into the impact of subsyndromal depressive symptoms on biological rhythm are needed. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Bipolar transistor in VESTIC technology: prototype

    Science.gov (United States)

    Mierzwiński, Piotr; Kuźmicz, Wiesław; Domański, Krzysztof; Tomaszewski, Daniel; Głuszko, Grzegorz

    2016-12-01

    VESTIC technology is an alternative for traditional CMOS technology. This paper presents first measurement data of prototypes of VES-BJT: bipolar transistors in VESTIC technology. The VES-BJT is a bipolar transistor on the SOI substrate with symmetric lateral structure and both emitter and collector made of polysilicon. The results indicate that VES-BJT can be a device with useful characteristics. Therefore, VESTIC technology has the potential to become a new BiCMOS-type technology with some unique properties.

  5. Comorbidity bipolar disorder and personality disorders.

    Science.gov (United States)

    Latalova, Klara; Prasko, Jan; Kamaradova, Dana; Sedlackova, Jana; Ociskova, Marie

    2013-01-01

    Outcome in bipolar patients can be affected by comorbidity of other psychiatric disorders. Comorbid personality disorders are frequent and may complicate the course of bipolar illness. We have much information about treating patients with uncomplicated bipolar disorder (BD) but much less knowledge about possibilities for patients with the comorbidity of BD and personality disorder. We conducted a series of literature searches using, as key words or as items in indexed fields, bipolar disorder and personality disorder or personality traits. Articles were obtained by searching MEDLINE from 1970 to 2012. In addition, we used other papers cited in articles from these searches, or cited in articles used in our own work. Tests of personality traits indicated that euthymic bipolar patients have higher scores on harm avoidance, reward dependence, and novelty seeking than controls. Elevation of novelty seeking in bipolar patients is associated with substance abuse comorbidity. Comorbidity with personality disorders in BD patients is associated with a more difficult course of illness (such as longer episodes, shorter time euthymic, and earlier age at onset) and an increase in comorbid substance abuse, suicidality and aggression. These problems are particularly pronounced in comorbidity with borderline personality disorder. Comorbidity with antisocial personality disorder elicits a similar spectrum of difficulties; some of the antisocial behavior exhibited by patients with this comorbidity is mediated by increased impulsivity.

  6. Sexual health and women with bipolar disorder.

    Science.gov (United States)

    McCandless, Fiona; Sladen, Claire

    2003-10-01

    The aim of this paper is to illustrate the importance of sexual health promotion strategies for women with bipolar disorder in order to stimulate interest and debate in this area of care. Sexual health promotion is an important aspect of holistic nursing care. However, the literature indicates that nurses are reluctant to discuss sexual health and sexual behaviour with their clients. People with bipolar disorder warrant special consideration with regards to sexual health because the nature of the manic, or hypomanic, mood state is associated in some cases with sexually risky behaviour. For women with bipolar disorder, the associated risks include the threat of unplanned pregnancy or sexually transmitted diseases. To ignore sexual health and sexual behaviour in mental health care increases the vulnerability of women who may already be at risk of sexual exploitation. CASE EXAMPLE: A brief case example is included to demonstrate how the sexual health of a young woman with bipolar disorder was promoted. The sexual health promotion that was incorporated into her care enabled her to make a choice about appropriate contraception, and also provided her with the opportunity to explore acceptable boundaries in different types of interpersonal relationships. As a result of the episodic nature of Bipolar disorder, it is impossible to state whether the positive outcomes from this strategy will be enduring or not. Consideration of sexual health is an essential element of the care of women with Bipolar disorder. To ignore it is to neglect an important sphere of human behaviour that can be affected by the condition.

  7. The role of sleep in bipolar disorder

    Directory of Open Access Journals (Sweden)

    Gold AK

    2016-06-01

    Full Text Available Alexandra K Gold,1 Louisa G Sylvia,1,2 1Department of Psychiatry, Massachusetts General Hospital, 2Harvard Medical School, Boston, MA, USA Abstract: Bipolar disorder is a serious mental illness characterized by alternating periods of elevated and depressed mood. Sleep disturbances in bipolar disorder are present during all stages of the condition and exert a negative impact on overall course, quality of life, and treatment outcomes. We examine the partnership between circadian system (process C functioning and sleep–wake homeostasis (process S on optimal sleep functioning and explore the role of disruptions in both systems on sleep disturbances in bipolar disorder. A convergence of evidence suggests that sleep problems in bipolar disorder result from dysregulation across both process C and process S systems. Biomarkers of depressive episodes include heightened fragmentation of rapid eye movement (REM sleep, reduced REM latency, increased REM density, and a greater percentage of awakenings, while biomarkers of manic episodes include reduced REM latency, greater percentage of stage I sleep, increased REM density, discontinuous sleep patterns, shortened total sleep time, and a greater time awake in bed. These findings highlight the importance of targeting novel treatments for sleep disturbance in bipolar disorder. Keywords: bipolar disorder, circadian rhythms, sleep–wake homeostasis

  8. Classification of cognitive performance in bipolar disorder.

    Science.gov (United States)

    Sparding, Timea; Silander, Katja; Pålsson, Erik; Östlind, Josefin; Ekman, Carl Johan; Sellgren, Carl M; Joas, Erik; Hansen, Stefan; Landén, Mikael

    2017-09-01

    To understand the etiology of cognitive impairment associated with bipolar disorder, we need to clarify potential heterogeneity in cognitive functioning. To this end, we used multivariate techniques to study if the correlation structure of cognitive abilities differs between persons with bipolar disorder and controls. Clinically stable patients with bipolar disorder (type I: n = 64; type II: n = 44) and healthy controls (n = 86) were assessed with a wide range of cognitive tests measuring executive function, speed, memory, and verbal skills. Data were analysed with multivariate techniques. A distinct subgroup (∼30%) could be identified that performed significantly poorer on tests concerning memory function. This cognitive phenotype subgroup did not differ from the majority of bipolar disorder patients with respect to other demographic or clinical characteristics. Whereas the majority of patients performed similar to controls, a subgroup of patients with bipolar disorder differed substantially from healthy controls in the correlation pattern of low-level cognitive abilities. This suggests that cognitive impairment is not a general trait in bipolar disorder but characteristic of a cognitive subgroup. This has important clinical implications for cognitive rehabilitation and remediation.

  9. Early maladaptive schemas in bipolar disorder.

    Science.gov (United States)

    Ak, Mehmet; Lapsekili, Nergis; Haciomeroglu, Bikem; Sutcigil, Levent; Turkcapar, Hakan

    2012-09-01

    According to the cognitive model of depression, negative schemas, formed in early life, increase susceptibility to depression. The objective of this study was to investigate schemas that are proposed to increase susceptibility of depression in bipolar disorder patients who have had depressive episodes. Eighteen patients diagnosed with bipolar disorder according to DSM-IV and a healthy control group (N= 20) constituted the sample of the study. The Beck Depression Inventory, Young Mania Rating Scale, and Young Schema Scale were applied to patients in order to determine the level of symptoms and schemas. When the scores obtained from Young Schema Scale were compared between groups, significant differences were observed between bipolar patients and control group on all the schemas except abandonment, emotional deprivation, defectiveness, vulnerability to harm or illness, and approval seeking. The negative schema scores of bipolar patients were significantly higher than those of the control group. Of all schemas included in the Young Schema Scale, the scores of bipolar group were higher than the scores of the control group. These findings suggest that, in cognitive-based psychotherapeutic approaches for patients with bipolar disorder, it would be more effective to focus on schemas related to the perception and allowance of feelings at the proper time and the instability of self-perceptions. © 2011 The British Psychological Society.

  10. Preparation of bipolar membranes by electrospinning

    International Nuclear Information System (INIS)

    Pan, Jiefeng; Hou, Linxiao; Wang, Qiuyue; He, Yubin; Wu, Liang; Mondal, Abhishek N.; Xu, Tongwen

    2017-01-01

    A new preparative pathway for the bipolar membranes was initiated via the electrospinning and hot-press process. The prepared bipolar membrane was consisting of sulfonated poly (phenylene oxide), polyethylene glycol, and quaternized poly (phenylene oxide). The above mentioned membrane was fabricated by the continuous electrospinning of the respective layer, followed by the solvent atmosphere treatment and hot-pressing, to obtain a transparent and dense structure. The thickness of each layer can be easily tuned by controlling the electrospinning parameters. The clear interfacial structure was observed and confirmed by the scanning electron microscope. The bipolar performance is evaluated by the current–voltage curves and production yield of acid and base. The final optimized bipolar membrane had similar yield of acid and base as the casting membrane. However, extremely lower potential drop value was observed when they are applied for the production of acid and base. The experimental results showed that, electrospinning is an effective and well controlled way to fabricate bipolar membranes, in which anion or cation exchange layer as well as interfacial layer can be easily changed or added as requested. - Highlights: • Bipolar membranes were prepared through electrospinning followed by post-treatment. • As-prepared membranes were successfully applied in electrodialysis for production of acid and base. • Electrospun membranes exhibit better performance than the casting ones.

  11. Preparation of bipolar membranes by electrospinning

    Energy Technology Data Exchange (ETDEWEB)

    Pan, Jiefeng; Hou, Linxiao; Wang, Qiuyue; He, Yubin; Wu, Liang; Mondal, Abhishek N.; Xu, Tongwen, E-mail: twxu@ustc.edu.cn

    2017-01-15

    A new preparative pathway for the bipolar membranes was initiated via the electrospinning and hot-press process. The prepared bipolar membrane was consisting of sulfonated poly (phenylene oxide), polyethylene glycol, and quaternized poly (phenylene oxide). The above mentioned membrane was fabricated by the continuous electrospinning of the respective layer, followed by the solvent atmosphere treatment and hot-pressing, to obtain a transparent and dense structure. The thickness of each layer can be easily tuned by controlling the electrospinning parameters. The clear interfacial structure was observed and confirmed by the scanning electron microscope. The bipolar performance is evaluated by the current–voltage curves and production yield of acid and base. The final optimized bipolar membrane had similar yield of acid and base as the casting membrane. However, extremely lower potential drop value was observed when they are applied for the production of acid and base. The experimental results showed that, electrospinning is an effective and well controlled way to fabricate bipolar membranes, in which anion or cation exchange layer as well as interfacial layer can be easily changed or added as requested. - Highlights: • Bipolar membranes were prepared through electrospinning followed by post-treatment. • As-prepared membranes were successfully applied in electrodialysis for production of acid and base. • Electrospun membranes exhibit better performance than the casting ones.

  12. Entrevista Percepción de Carga del Cuidado de Zarit: pruebas psicométricas para Colombia

    Directory of Open Access Journals (Sweden)

    Ruth Vivian Barreto-Osorio

    2015-01-01

    Full Text Available Objetivo: determinar la validez y confiabilidad de la Entrevista de Percepción de Carga del Cuidado de Zarit, versión de 22 ítems en español, con cuidadores familiares de personas con enfermedades crónicas en Colombia. Materiales y métodos: estudio metodoló- gico de corte transversal, con 652 cuidadores familiares de personas con enfermedades crónicas, residentes en las cinco regiones de Colombia, con el fin de establecer la validez de constructo, con un análisis factorial y la confiabilidad a través de la consistencia interna determinando el alfa de Cronbach. Resultado: respecto a la validez de constructo, el estudio reporta a partir de la asociación libre de la rotación Varimax la carga total, y en sus dimensiones que incluyen carga interpersonal, impacto del cuidado, y las competencias y expectativas sobre el cuidado. Las cargas factoriales corresponden a los ítems planteados para medir cada una de las dimensiones propuestas. Conclusión: el instrumento Entrevista de Percepción de Carga del Cuidado de Zarit, versión de 22 ítems en español, es una herramienta de fácil aplicación y comprensión en población colombiana de diferente nivel educativo, socioeconómico y cultural; además, mostró ser válido y confiable para evaluar la carga del cuidado en cuidadores familiares de personas con enfermedad crónica.

  13. Aferição das cargas a aplicar a nadadores no teste Wingate em cicloergómetro

    Directory of Open Access Journals (Sweden)

    Susana Maria Soares

    2013-12-01

    Full Text Available O teste Wingate parece ser o teste padrão para avaliar o potencial anaeróbio, implicando a aplicação de uma carga de resistência cujo valor é uma percentagem do peso corporal do sujeito a avaliar. O objetivo do presente estudo foi o de determinar a carga de resistência, expressa em percentagem do peso corporal, a aplicar a nadadores no teste Wingate realizado em cicloergómetro. A amostra foi constituída por sete nadadores e sete nadadoras. Para aferir a carga ótima de resistência a aplicar a cada nadador foi realizado um pré-teste de nx10s, com um intervalo de 15min entre cada repetição. A resistência aplicada em cada repetição foi de 7.5% do peso corporal, aumentada em frações de 0.5%. A carga de resistência ótima determinada no pré-teste foi aplicada no teste Wingate tal como determinada e incrementada e subtraída em 0.5% do peso corporal, tendo-se verificado uma relação não-linear entre a potência e a carga externa. A carga de resistência ótima a aplicar no teste Wingate foi superior ao valor padrão de 7.5%, quer para os nadadores (9.50 ± 0.65%, quer para as nadadoras (9.86 ± 1.18%.

  14. Relações afetivo-sexuais e prevenção contra infecções sexualmente transmissíveis e aids entre mulheres do município de Vitória - ES

    OpenAIRE

    Amorim, Melissa Mattos; Andrade, Ângela Nobre de

    2006-01-01

    Objetivou-se conhecer como mulheres vivenciam a prevenção de infecções sexualmente transmissíveis (IST) e aids em suas relações afetivo-sexuais. Foram realizados dois grupos de discussão e 12 entrevistas individuais com mulheres na faixa etária de 20 a 35 anos. Um grupo foi composto por cinco participantes com ensino fundamental ou médio (Grupo1) e o outro, por sete participantes com ensino superior completo ou incompleto (Grupo2). Apenas três participantes faziam uso consistente do preservat...

  15. Transtorno de estresse pós-traumático em jovens: prevalência, avaliação da qualidade de vida e dos temperamentos afetivo e emocional e qualidade de vida

    OpenAIRE

    Medeiros, Letícia Galery

    2014-01-01

    O presente trabalho consta de dois estudos independentes. O primeiro teve por objetivo verificar a prevalência de transtorno de estresse pós-traumático (TEPT) atual entre jovens, a ocorrência de comorbidades e a associação com qualidade de vida. O segundo estudo visou identificar os tipos de temperamento emocional e afetivo associados ao TEPT. Ambos os estudos caracterizaram-se pelo corte transversal de base populacional. A população-alvo do estudo I foram indivíduos de 18 a 24 anos de idade,...

  16. Comportamiento de paneles de bambú guadua laminado ante cargas paralelas al plano

    Directory of Open Access Journals (Sweden)

    Juan Jacobo Pinilla Rodríguez

    2012-05-01

    Full Text Available Como un primer paso en el estudio del comportamiento ante cargas sísmicas de pórticos de bambú guadua laminados con paneles del mismo material, el Grupo de Investigación “Análisis, Diseño y Materiales, GIES”, de la Universidad Nacional de Colombia, ensayó dos tipos de paneles elaborados con bambú Guadua angustifolia Kunth y poli (vinil acetato, PVA: los paneles tipo 1 de sección transversal maciza y los paneles tipo 2 de sección transversal tipo sándwich.Se consideraron tres alturas para cada tipo de panel y se ensayaron diez réplicas por altura y por tipo, para un total de sesenta ensayos.Para cada uno de los paneles ensayados se realizó una curva carga-desplazamiento. Los paneles tipo 1, con altura de 0,34 m y 0,63 m, mostraron un comportamiento elástico inicial seguido de un comportamiento inelástico, mientras que los paneles tipo 1 y 2 de 0,98 m de altura revelaron un comportamiento casi totalmente elástico hasta la falla. Todos los paneles sufrieron aplastamiento en la base; sin embargo, el principal mecanismo de falla fue el alabeo.

  17. Ensayo sobre endurecimiento de adhesivos estructurales sometidos a cargas dinámicas

    Directory of Open Access Journals (Sweden)

    Recuero, A.

    2004-04-01

    Full Text Available Carbon fibre reinforced polymers are increasingly replacing the steel reinforcing systems in the repair and strengthening of concrete structures thanks to their high strength/weight and stiffness/weight ratios, corrosion resistance, lightweight, and ease of handling and application. This paper presents a study on the behaviour of bridge concrete beams strengthened with CFRP sheets when the strengthening is made when traffic is acting so that the structure is subjected to dynamic loads while the adhesive is still fresh. No reduction in the effectiveness of the strengthening was observed in the tests.

    Los polímeros reforzados con fibras de carbono se están utilizando cada vez más para el refuerzo de estructuras de hormigón, reemplazando a los sistemas tradicionales de refuerzo con acero. Esto es debido a sus altas resistencia y rigidez específicas, resistencia a la corrosión, ligereza y facilidad de manejo y puesta en obra. Este artículo presenta un estudio sobre el comportamiento de vigas de puentes reforzadas con bandas de CFRP mientras se mantiene el puente en servicio de manera que la estructura está sometida a cargas dinámicas con el adhesivo fresco. En los ensayos realizados se ha observado que las cargas dinámicas no afectan a la efectividad del refuerzo.

  18. SIMULACIÓN DE PRUEBAS DE CARGA EN PILOTES USANDO UN MODELO CONSTITUTIVO HIPOPLÁSTICO

    Directory of Open Access Journals (Sweden)

    Juan Carlos Ruge Cárdenas

    Full Text Available La presente investigación tuvo como objetivo principal, simular mediante el empleo de un programa basado en el método de elementos finitos, los resultados obtenidos de pruebas de carga en pilotes individuales fundados en arcillas porosas de Brasilia DF (Brasil, las cuales poseen características metaestables. Para las simulaciones se empleó la ecuación constitutiva hipoplástica. Los parámetros del suelo fueron obtenidos por medio de ensayos de laboratorio que permitieron estimar propiedades geotécnicas del suelo, así como parámetros de resistencia, deformabilidad e identificación estratigráfica. Como conclusión general se reporta que la predicción aportada por el modelo hipoplástico en relación a las pruebas de carga en el tramo antes de la ruptura es aceptable, sin embargo debido a la pérdida de adhesión en la interface suelo-pilote en el momento de la prueba, se nota la incapacidad del modelo para simular este efecto de manera adecuada, ya que existen condiciones de metaestabilidad y de parcial saturación presentes en el problema geotécnico.

  19. La carga física de los trabajadores: estrategia administrativa en la mejora de procesos

    Directory of Open Access Journals (Sweden)

    Grether Lucía Real Pérez

    2015-06-01

    Full Text Available La administración surge cuando existe la necesidad de manejar recursos. Los administradores deben planificar, organizar, dirigir y controlar todos los elementos de los procesos, considerando los medios de trabajo, los objetos de trabajo y las personas. Este último es el eslabón fundamental del proceso productivo o de servicio. Se debe considerar además el entorno y su relación con el medio ambiente, permitiendo ser a las empresas responsables con los tres pilares fundamentales: la sociedad, el medio ambiente, y la economía. La Ergonomía, como ciencia aplicada, permite garantizar las condiciones de seguridad, salud y bienestar a sus trabajadores, logrando ser más productivos, eficientes, eficaces y competitivos. El objetivo de la investigación fue conocer las implicaciones de la carga física en los trabajadores, utilizando una herramienta de diagnóstico que permitió, como resultado fundamental, el establecimiento de programas de mejoras ajustados a cada una de las realidades de los puestos de trabajo. Palabras clave: Ergonomía, Administración, Carga física, Factores de riesgo, Programa de mejoras

  20. O movimento de cargas em capacitores e a velocidade limite de acordo com a lei de Weber

    OpenAIRE

    João Jose Caluzi

    1991-01-01

    Resumo: O presente trabalho aplica o formalismo Weberiano ao estudo do movimento de uma carga em um capacitor plano ideal. utilizando a energia proposta por W. Weber em 1848. O objetivo é estudar a existência ou não de uma velocidade limite neste formalismo. A situação estudada é a de uma carga movendo-se ortogonalmente às placas de um capacitor plano ideal. onde são desprezados os efeitos de borda e de radiação eletromagnética. O primeiro caso estudado é o de uma energia potencial Cou...

  1. Factores de riesgo social y carga alostática en el adulto mayor: propuesta de un modelo

    Directory of Open Access Journals (Sweden)

    Alejandro Morales Jinez

    2014-12-01

    Full Text Available El objetivo del presente artículo es proponer un modelo de factores de riesgo social en el que se describen estresores predisponentes para la carga alostática en los adultos mayores de 60 años. Carga alostática se refiere al uso y desgaste del organismo humano. Este trabajo contribuye al conocimiento de enfermería aportando evidencia hacia la dimensión social como un componente de riesgo al bienestar de los adultos mayores.

  2. Tratamento da depressão bipolar The treatment of bipolar depression

    Directory of Open Access Journals (Sweden)

    Beny Lafer

    2005-01-01

    Full Text Available O tratamento da depressão bipolar tem sido tema de debate. O uso de antidepressivos, principalmente tricíclicos, nestes pacientes está associado a piores desfechos clínicos. Estudos apontam para uma eficácia limitada de estabilizadores tradicionais como lítio, valproato e carbamazepina no tratamento da depressão bipolar. Em casos de depressão mais grave, há indicativos de que os antidepressivos podem ser úteis, sendo recomendado o uso concomitante de um estabilizador do humor. Novos agentes como a lamotrigina têm sido propostos como efetivos no tratamento da depressão bipolar. Estudos recentes utilizando lamotrigina sugerem a sua eficácia e seguraça no tratamento da depressão bipolar.The treatment of bipolar depression has been an area of debate. The use of antidepressants, particularly the triciclics, has been associated with worse clinical outcomes. Evidence points to a limited efficacy of traditional mood stabilizers such as lithium, valproate and carbamazepine in the treatment of bipolar depression. In cases where depression is more severe, there is evidence that antidepressants may be useful. The use of antidepressants should be in association with a mood stabilizer. New agents such as lamotrigine have been put forward as effective in the treatment of bipolar depression. Recent studies using lamotrigine suggest its efficacy and safety in the treatment of bipolar depression.

  3. Clinical, Demographic, and Familial Correlates of Bipolar Spectrum Disorders among Offspring of Parents with Bipolar Disorder

    Science.gov (United States)

    Goldstein, Benjamin I.; Shamseddeen, Wael; Axelson, David A.; Kalas, Cathy; Monk, Kelly; Brent, David A.; Kupfer, David J.; Birmaher, Boris

    2010-01-01

    Objective: Despite increased risk, most offspring of parents with bipolar disorder (BP) do not manifest BP. The identification of risk factors for BP among offspring could improve preventive and treatment strategies. We examined this topic in the Pittsburgh Bipolar Offspring Study (BIOS). Method: Subjects included 388 offspring, ages 7-17 years,…

  4. Terapia comportamental cognitiva para pessoas com transtorno bipolar Cognitive behavioral therapy for bipolar disorders

    Directory of Open Access Journals (Sweden)

    Francisco Lotufo Neto

    2004-10-01

    Full Text Available Descrição dos objetivos e principais técnicas da terapia comportamental cognitiva usadas para a psicoterapia das pessoas com transtorno bipolar.Objectives and main techniques of cognitive behavior therapy for the treatment of bipolar disorder patients are described.

  5. [Circadian markers and genes in bipolar disorder].

    Science.gov (United States)

    Yeim, S; Boudebesse, C; Etain, B; Belliviera, F

    2015-09-01

    Bipolar disorder is a severe and complex multifactorial disease, characterized by alternance of acute episodes of depression and mania/hypomania, interspaced by euthymic periods. The etiological determinants of bipolar disorder yet, are still poorly understood. For the last 30 years, chronobiology is an important field of investigation to better understand the pathophysiology of bipolar disorder. We conducted a review using Medline, ISI Database, EMBase, PsyInfo up to January 2015, using the following keywords combinations: "mood disorder", "bipolar disorder", "depression", "unipolar disorder", "major depressive disorder", "affective disorder", for psychiatric conditions; and "circadian rhythms", "circadian markers", "circadian gene", "clock gene", "melatonin" for circadian rhythms. The search critera was presence of word in any field of the article. Quantitative and qualitative circadian abnormalities are associated with bipolar disorders both during acute episodes and euthymic periods, suggesting that these altered circadian rhythms may represent biological trait markers of the disorder. These circadian dysfunctions were assessed by various validated tools including polysomnography, actigraphy, sleep diaries, chronotype assessments and blood melatonin/cortisol measures. Other altered endogenous circadian activities have also been reported in bipolar patients, such as hormones secretion, core body temperature or fibroblasts activity. Moreover, these markers were also altered in healthy relatives of bipolar patients, suggesting a degree of heritability. Several genetic association studies have also showed associations between multiple circadian genes and bipolar disorder, such as CLOCK, ARTNL1, GSK3β, PER3, NPAS2, NR1D1, TIMELESS, RORA, RORB, and CSNK1ε. Thus, these circadian gene variants may contribute to the genetic susceptibility of the disease. Furthermore, the study of the clock system may help to better understand some phenotypic aspects like the

  6. The International Society for Bipolar Disorders (ISBD) Task Force Report on Antidepressant Use in Bipolar Disorders

    Science.gov (United States)

    Pacchiarotti, Isabella; Bond, David J.; Baldessarini, Ross J.; Nolen, Willem A.; Grunze, Heinz; Licht, Rasmus W.; Post, Robert M.; Berk, Michael; Goodwin, Guy M.; Sachs, Gary S.; Tondo, Leonardo; Findling, Robert L.; Youngstrom, Eric A.; Tohen, Mauricio; Undurraga, Juan; González-Pinto, Ana; Goldberg, Joseph F.; Yildiz, Ayşegül; Altshuler, Lori L.; Calabrese, Joseph R.; Mitchell, Philip B.; Thase, Michael E.; Koukopoulos, Athanasios; Colom, Francesc; Frye, Mark A.; Malhi, Gin S.; Fountoulakis, Konstantinos N.; Vázquez, Gustavo; Perlis, Roy H.; Ketter, Terence A.; Cassidy, Frederick; Akiskal, Hagop; Azorin, Jean-Michel; Valentí, Marc; Mazzei, Diego Hidalgo; Lafer, Beny; Kato, Tadafumi; Mazzarini, Lorenzo; Martínez-Aran, Anabel; Parker, Gordon; Souery, Daniel; Özerdem, Ayşegül; McElroy, Susan L.; Girardi, Paolo; Bauer, Michael; Yatham, Lakshmi N.; Zarate, Carlos A.; Nierenberg, Andrew A.; Birmaher, Boris; Kanba, Shigenobu; El-Mallakh, Rif S.; Serretti, Alessandro; Rihmer, Zoltan; Young, Allan H.; Kotzalidis, Georgios D.; MacQueen, Glenda M.; Bowden, Charles L.; Ghaemi, S. Nassir; Lopez-Jaramillo, Carlos; Rybakowski, Janusz; Ha, Kyooseob; Perugi, Giulio; Kasper, Siegfried; Amsterdam, Jay D.; Hirschfeld, Robert M.; Kapczinski, Flávio; Vieta, Eduard

    2014-01-01

    Objective The risk-benefit profile of antidepressant medications in bipolar disorder is controversial. When conclusive evidence is lacking, expert consensus can guide treatment decisions. The International Society for Bipolar Disorders (ISBD) convened a task force to seek consensus recommendations on the use of antidepressants in bipolar disorders. Method An expert task force iteratively developed consensus through serial consensus-based revisions using the Delphi method. Initial survey items were based on systematic review of the literature. Subsequent surveys included new or reworded items and items that needed to be rerated. This process resulted in the final ISBD Task Force clinical recommendations on antidepressant use in bipolar disorder. Results There is striking incongruity between the wide use of and the weak evidence base for the efficacy and safety of antidepressant drugs in bipolar disorder. Few well-designed, long-term trials of prophylactic benefits have been conducted, and there is insufficient evidence for treatment benefits with antidepressants combined with mood stabilizers. A major concern is the risk for mood switch to hypomania, mania, and mixed states. Integrating the evidence and the experience of the task force members, a consensus was reached on 12 statements on the use of antidepressants in bipolar disorder. Conclusions Because of limited data, the task force could not make broad statements endorsing antidepressant use but acknowledged that individual bipolar patients may benefit from antidepressants. Regarding safety, serotonin reuptake inhibitors and bupropion may have lower rates of manic switch than tricyclic and tetracyclic antidepressants and norepinephrine-serotonin reuptake inhibitors. The frequency and severity of antidepressant-associated mood elevations appear to be greater in bipolar I than bipolar II disorder. Hence, in bipolar I patients antidepressants should be prescribed only as an adjunct to mood-stabilizing medications

  7. Bipolar postpartum depression: An update and recommendations.

    Science.gov (United States)

    Sharma, Verinder; Doobay, Minakshi; Baczynski, Christine

    2017-09-01

    Over the past few years there has been a surge of interest in the study of bipolar postpartum depression (PPD); however, questions remain about its prevalence, screening, clinical features, and treatment. Three electronic databases, MEDLINE/PubMed (1966-2016), PsycINFO (1806-2016), and the Cochrane Database of Systematic Reviews, were searched using a combination of the keywords bipolar, depression, postpartum, peripartum, prevalence, screening, diagnosis, treatment, drugs, and psychotherapy. The reference lists of articles identified were also searched. All relevant articles published in English were included. Depending on the population studied, 21.4-54% of women with PPD have a diagnosis of bipolar disorder (BD). Characteristic clinical features include younger age at illness onset, first onset of depression after childbirth, onset immediately after delivery, atypical depressive symptoms, psychotic features, mixed features, and history of BD in first-degree family members. Treatment should be guided by symptom acuity, safety concerns, the patient's response to past treatments, drug tolerability, and breastfeeding preference. In the absence of controlled treatment data, preference should be given to drugs normally indicated for bipolar depression including lithium, quetiapine and lamotrigine. Although antidepressants have been studied in combination with mood stabilizers in bipolar depression, these drugs should be avoided due to likelihood of elevated risk of induction of manic symptoms in the postpartum period. In the postpartum period, bipolar PPD is common, can be differentiated from unipolar PPD, and needs to be identified promptly in order to expedite appropriate treatment. Future studies on pharmacotherapy and psychotherapy should focus on the acute and preventative treatment of bipolar PPD. Copyright © 2017 Elsevier B.V. All rights reserved.

  8. DISEÑO E IMPLEMENTACIÓN DE UN BANCO DE CARGA MONOFÁSICO PARA PRUEBAS DE CARGA EN SISTEMAS DE ALIMENTACIÓN ININTERRUMPIDAS MONOFÁSICAS CON CAPACIDADES ENTRE 1 Y 2 KVA

    Directory of Open Access Journals (Sweden)

    Pablo Emilio Rozo García

    2013-09-01

    Full Text Available En este documento se describe el proyecto correspondiente a el diseño e implementación de un banco de carga de tipo resistivo para pruebas de carga en Sistemas de alimentación ininterrumpidas monofásicas de capacidades comprendidas entre 1 KVA y 2 KVA. La estructura del proyecto presenta inicialmente la descripción teórica sobre los conceptos fundamentales en electrónica de potencia y en referencia con los bancos de carga que se encuentran actualmente en el mercado. Posteriormente se realiza el diseño del banco de carga resistivo con base en la investigación ya existente y finalmente se implementa el diseño, resaltando los resultados obtenidos, conclusiones, dificultades técnicas y  mejoras al proyecto. A partir de los resultados obtenidos, se entrega una herramienta de trabajo para la industria de sistemas de potencia en general y material de investigación en áreas relacionadas con el análisis de la calidad de energía y electrónica de potencia.

  9. Big data for bipolar disorder.

    Science.gov (United States)

    Monteith, Scott; Glenn, Tasha; Geddes, John; Whybrow, Peter C; Bauer, Michael

    2016-12-01

    The delivery of psychiatric care is changing with a new emphasis on integrated care, preventative measures, population health, and the biological basis of disease. Fundamental to this transformation are big data and advances in the ability to analyze these data. The impact of big data on the routine treatment of bipolar disorder today and in the near future is discussed, with examples that relate to health policy, the discovery of new associations, and the study of rare events. The primary sources of big data today are electronic medical records (EMR), claims, and registry data from providers and payers. In the near future, data created by patients from active monitoring, passive monitoring of Internet and smartphone activities, and from sensors may be integrated with the EMR. Diverse data sources from outside of medicine, such as government financial data, will be linked for research. Over the long term, genetic and imaging data will be integrated with the EMR, and there will be more emphasis on predictive models. Many technical challenges remain when analyzing big data that relates to size, heterogeneity, complexity, and unstructured text data in the EMR. Human judgement and subject matter expertise are critical parts of big data analysis, and the active participation of psychiatrists is needed throughout the analytical process.

  10. Bipolar disorder and neurophysiologic mechanisms

    Science.gov (United States)

    McCrea, Simon M

    2008-01-01

    Recent studies have suggested that some variants of bipolar disorder (BD) may be due to hyperconnectivity between orbitofrontal (OFC) and temporal pole (TP) structures in the dominant hemisphere. Some initial MRI studies noticed that there were corpus callosum abnormalities within specific regional areas and it was hypothesized that developmentally this could result in functional or effective connectivity changes within the orbitofrontal-basal ganglia-thalamocortical circuits. Recent diffusion tensor imaging (DTI) white matter fiber tractography studies may well be superior to region of interest (ROI) DTI in understanding BD. A “ventral semantic stream” has been discovered connecting the TP and OFC through the uncinate and inferior longitudinal fasciculi and the elusive TP is known to be involved in theory of mind and complex narrative understanding tasks. The OFC is involved in abstract valuation in goal and sub-goal structures and the TP may be critical in binding semantic memory with person–emotion linkages associated with narrative. BD patients have relative attenuation of performance on visuoconstructional praxis consistent with an atypical localization of cognitive functions. Multiple lines of evidence suggest that some BD alleles are being selected for which could explain the enhanced creativity in higher-ability probands. Associations between ROI’s that are not normally connected could explain the higher incidence of artistic aptitude, writing ability, and scientific achievements among some mood disorder subjects. PMID:19337455

  11. Carga inmediata con implantes en maxilar superior Immediate loading of implants in the maxilla

    Directory of Open Access Journals (Sweden)

    F. Monje Gil

    2007-08-01

    Full Text Available La carga inmediata en la mandíbula se ha incorporado a la práctica clínica en primer lugar y, por las características del hueso, se realiza de forma protocolizada. Sin embargo, en el maxilar superior no hay evidencia científica para realizarlo de forma cotidiana. Las razones son debidas a que el maxilar superior, en general, alberga una masa ósea de menor densidad. Por otro lado, en el maxilar superior pueden coexistir diferentes densidades óseas (según la clasificación de Misch en el mismo individuo. Además, por las características anatómicas del maxilar superior (reabsorción labiopalatina el alineamiento axial es asumible pero, sin embargo, el paralelismo de los implantes es difícil.16,17 El objetivo del presente trabajo es analizar la información científica de la que disponemos para confirmar si es posible la carga inmediata sobre el maxilar superior. Para ello estudiaremos varios aspectos de la carga inmediata en el maxilar superior: • Sobredentaduras • Prótesis fija completa • Prótesis parcial fija • Prótesis unitaria fija • Requerimientos protésicos • ContraindicacionesImmediate loading in the mandible has been introduced into clinical practice taking first place and, and because of the characteristics of the bone, this is carried out following a protocol. However, in the maxilla there is no scientific evidence for routinely carrying this out. This is because the maxilla, in general, has a lower bone mass density. Moreover, in the maxilla various densities may coexist (according to Misch’s classification in the same individual. In addition, given the anatomic characteristics of the maxilla (lip and palate resorption, axial alignment can be carried out, but implant parallelism is difficult.16,17 The aim of this paper is to analyze the scientific information that we have at our disposal in order to confirm whether immediate loading in the maxilla is possible. For this we will study various aspects of

  12. Pandeo de paraboloides hiperbólicos con cargas uniformes en cualquier dirección

    Directory of Open Access Journals (Sweden)

    Escrig, Félix

    1980-12-01

    Full Text Available This article discusses how to obtain the critical buckling load a hyperbolic paraboloid, with even loads in any direction, following a different criterion to Reissner, that has commonly been used up until now. Consequently, instead of using a general system, function of tensions and displacements, a different concept is used: that of minimum of the total potential energy. Likewise, displacements and not efforts are related, through the paraboloid canonic equation. The equation system is resolved through a computer program that permits the indication that the Reissner values remain on the unfavourable side, in spite of the fact that the arrows criterion has not been used in this work, and with whch even smaller buckling critical load values would have been obtained. In the future, by perfecting this method, its field of application can be increased.

    Este artículo trata de la obtención de la carga crítica de pandeo en un paraboloide hiperbólico con cargas uniformes en cualquier dirección siguiendo un criterio diferente al de Reissner, comúnmente empleado hasta ahora. Para ello, en vez de partir de un sistema general, función de tensiones y desplazamientos, se utiliza un concepto distinto: el del mínimo de la energía potencial total. Asimismo se relacionan desplazamientos, y no esfuerzos, a través de la ecuación canónica del paraboloide. La resolución del sistema de ecuaciones resultante mediante programa de ordenador permite señalar que los valores de Reissner quedan del lado desfavorable, a pesar de no haberse empleado en este trabajo el criterio de flechas, con el que se hubiesen obtenido valores de la carga crítica de pandeo todavía más pequeños. El perfeccionamiento del método permitirá en el futuro ampliar su campo de aplicación.

  13. O papel dos antipsicóticos atípicos no tratamento do transtorno bipolar: revisão da literatura The role of atypical antipsychotic agents in the treatment of bipolar disorder: a literature review

    Directory of Open Access Journals (Sweden)

    Acioly LT Lacerda

    2002-03-01

    Full Text Available Estudos recentes têm demonstrado que a eficácia do lítio é significativamente inferior à descrita pelos primeiros trabalhos, embora ainda seja a medicação de referência no tratamento do transtorno afetivo bipolar. Apesar de um perfil de segurança desfavorável, os antipsicóticos clássicos sempre apresentaram um papel importante no tratamento desse transtorno psiquiátrico, especialmente como coadjuvante em sua fase maníaca aguda. Os autores, utilizando informação obtida no Medline, fizeram uma revisão acerca do papel dos antipsicóticos atípicos no tratamento dos pacientes bipolares. Baseado nos dados da literatura, a olanzapina mostrou-se bastante eficaz no manejo da mania aguda, quando uma média de 63,5% dos pacientes apresentaram melhora significativa em estudos duplo-cego controlados, apresentando ganho de peso como único efeito colateral relevante. A clozapina e, mais ainda, a risperidona apresentaram dados menos consistentes, grande parte em função de deficiências metodológicas dos poucos estudos conduzidos até o presente estudo. Os dados preliminares relativos à eficácia desse grupo farmacológico nos quadros refratários e nos sintomas depressivos são promissores, mas ainda não definitivos. Em relação a seus efeitos potenciais como estabilizadores do humor, não existem evidências conclusivas oriundas de estudos controlados, mas há interesse considerável para realização de investigações em pacientes bipolares tratados com antipsicóticos atípicos por períodos de tempo mais prolongados. Pesquisas futuras poderão tornar mais claras essas possíveis características terapêuticas.Even though lithium is still the choice drug in the treatment of bipolar disorder, recent studies have shown that it has a significant lower efficacy than previously described in earlier studies. Despite its adverse side effects, typical antipsychotic agents have often had a prominent role in the treatment of this psychiatric

  14. Bipolar disorder: an update | Outhoff | South African Family Practice

    African Journals Online (AJOL)

    Bipolar disorder, characterised by alternating discrete episodes of (hypo)mania and depression, provides unique diagnostic and treatment challenges. Updated diagnostic (DSM-5) and current pharmacological treatment recommendations are briefly reviewed here. Keywords: bipolar disorder; diagnosis; evidence-based ...

  15. Cytokines in bipolar disorder vs. healthy control subjects

    DEFF Research Database (Denmark)

    Munkholm, Klaus; Braüner, Julie Vestergaard; Kessing, Lars Vedel

    2013-01-01

    Bipolar disorder may be associated with peripheral immune system dysfunction; however, results in individual studies are conflicting. Our aim was to systematically review evidence of peripheral cytokine alterations in bipolar disorder integrating findings from various affective states....

  16. Assessment of subjective and objective cognitive function in bipolar disorder

    DEFF Research Database (Denmark)

    Demant, Kirsa M; Vinberg, Maj; Kessing, Lars V

    2015-01-01

    Cognitive dysfunction is prevalent in bipolar disorder (BD). However, the evidence regarding the association between subjective cognitive complaints, objective cognitive performance and psychosocial function is sparse and inconsistent. Seventy seven patients with bipolar disorder who presented...

  17. Application of Bipolar Fuzzy Sets in Graph Structures

    Directory of Open Access Journals (Sweden)

    Muhammad Akram

    2016-01-01

    Full Text Available A graph structure is a useful tool in solving the combinatorial problems in different areas of computer science and computational intelligence systems. In this paper, we apply the concept of bipolar fuzzy sets to graph structures. We introduce certain notions, including bipolar fuzzy graph structure (BFGS, strong bipolar fuzzy graph structure, bipolar fuzzy Ni-cycle, bipolar fuzzy Ni-tree, bipolar fuzzy Ni-cut vertex, and bipolar fuzzy Ni-bridge, and illustrate these notions by several examples. We study ϕ-complement, self-complement, strong self-complement, and totally strong self-complement in bipolar fuzzy graph structures, and we investigate some of their interesting properties.

  18. Cardiovascular risk factors in outpatients with bipolar disorder

    NARCIS (Netherlands)

    Klumpers, U.M.H.; Boom, K.; Janssen, F.M.G.; Tulen, J.H.M.; Loonen, Anton J. M.

    2004-01-01

    Background: The mortality due to cardiovascular diseases in bipolar patients is much higher than in the general population. It is unclear whether lithium treatment contributes to this cardiovascular morbidity. Methods: The cardiovascular risk factors in outpatients with bipolar disorder on

  19. El sistema de transporte de carga en la Ciudad de México. Factores a considerar en el análisis del transporte de carga y la movilidad de mercancías

    Directory of Open Access Journals (Sweden)

    Floriu00E1n Rosa Martu00EDnez Perdomo

    2009-01-01

    Full Text Available El artículo presenta un análisis del sistema de transporte de carga en la Ciudad de México desde el punto de vista sistémico, considerando las variables económicas, políticas, técnicas, sociales que permitan comprender la problemática que actualmente enfrenta esta ciudad en la movilidad de mercancías. Es una reflexión de carácter multidisciplinario basada en el método cualitativo para explicar y comprender la situación actual del transporte de carga en México dentro del contexto de la globalización económica, para identificar así la naturaleza profunda de la estructura dinámica del transporte de carga en la Ciudad y la nueva forma de conceptualizar al transporte de mercancías. Se estudia el comportamiento de los flujos e infraestructura de las redes viales, las características urbanas, los instrumentos jurídicos en las políticas del transporte, la problemática del transporte de carga, así como la movilidad y los diferentes problemas que enfrenta el sector en relación con la ciudad. El objetivo principal de presente artículo es enunciar las razones por las que no existe un sistema de transporte articulado y se privilegia el uso del autotransporte de carga. Finalmente, de acuerdo a las diversas variables analizadas, se establece en las conclusiones que el análisis y la planificación de los transportes debe ser multi e interdisciplinario por naturaleza, con una visión integral para establecer un equilibrio entre los modos de transporte.

  20. AFETIVIDADE INSTITUCIONAL: REFLEXÕES SOBRE AS CONTRIBUIÇÕES DA PSICOLOGIA NA GESTÃO DO AFETIVO NAS ORGANIZAÇÕES DE TRABALHO

    Directory of Open Access Journals (Sweden)

    Regina Lúcia Moura Araújo

    2010-07-01

    Full Text Available O artigo tece considerações sobre o modelo de referência da afetividade institucional e analisa a relação entre a problemática dos trabalhadores e a atuação dos psicólogos do trabalho, com o objetivo de refletir sobre a contribuição desse modelo para orientar um posicionamento ético-político desses profissionais frente às atividades que desenvolvem. Ilustra suas observações mediante uma análise das práticas dos psicólogos do trabalho no marco das “faces da Psicologia do Trabalho”. Associa as possibilidades de solução para os problemas dos trabalhadores a atuação dos psicólogos do trabalho no campo da saúde do trabalhador. Sugere que o psicólogo do trabalho poderá edificar sua atuação, contribuindo na facilitação da construção e implementação de um modelo de gestão do afetivo, que se refere a um processo flexível de apropriação pela organização de conceitos, metodologias e recursos experimentais de mudanças, que permitam a promoção da saúde e a prevenção do adoecimento no trabalho. Portanto, indica que o seu papel revela-se não como simples desenvolvimento de tecnologias de avaliação e de controle, mas como facilitação da construção de espaços de interação social para proporcionar uma existência dialogada entre os diferentes sujeitos envolvidos com a atividade laboral e como promoção da qualidade de vida e bem-estar dos trabalhadores.

  1. Influencia de Las Cargas Térmicas Sobre Flujos de Aire Generados en Una Habitación

    DEFF Research Database (Denmark)

    Olmedo, Inés; de Adana, Manuel Ruiz; Nielsen, Peter V.

    La distribución de aire generada por los difusores en recinto interiores es crucial para obtener las características de aire y confort térmico deseadas. Los difusores de baja velocidad son altamente recomendados para muchas aplicaciones por sus numerosas ventajas. Sin embargo las cargas térmicas ...

  2. Carga de trabalho de enfermagem em unidade de terapia intensiva de cardiologia e fatores clínicos associados

    Directory of Open Access Journals (Sweden)

    Filipe Utuari de Andrade Coelho

    2011-01-01

    Full Text Available El estudio tuvo como objetivo identificar la carga de trabajo de enfermería en la Unidad de Cuidados Intensivos de Cardiología y verificar la asociación de esta variable con características demográficas y clínicas de los pacientes. La muestra consistió en cien pacientes hospitalizados entre agosto y septiembre de 2006, en la Unidad de Cuidados Intensivos de Cardiología de un hospital privado de Sao Paulo. El Nursing Activities Score, Symplified Acute Physiologic ScoreII y Logistic Organ Disfunction System se utilizaron para medir la carga de trabajo de enfermería, la gravedad y disfunción orgánica, respectivamente. La carga de trabajo de enfermería fue del 66,60%, equivalente a 5,30 horas de trabajo en un turno de ocho horas. Excepto por el tiempo pasado en la Unidad de Cuidados Intensivos que mostró una correlación moderada con la carga de trabajo, no hubo asociación con las otras variables. Se recomienda ampliar la muestra para conclusiones generalizadas.

  3. CARACTERIZACIÓN DEL TALLO ACEPTOR DEL tRNA MEDIANTE DESCRIPTORES LOCALES BASADOS EN CARGAS PARCIALES

    Directory of Open Access Journals (Sweden)

    Ray Marín

    2009-04-01

    Full Text Available En este trabajo se caracteriza la distribución de carga del tallo aceptor del tRNA, considerando todas las posibles combinaciones de pares Watson-Crick. El estudio se realizó con 256 fragmentos moleculares de 10 nucleótidos que modelan los tres primeros pares del tallo aceptor, la base diferenciadora y el extremo CCA. Para caracterizar los nucleótidos se proponen dos descriptores locales basados en la distribución de carga de las base nitrogenada de cada nucleótido, los cuales se calculan a partir de las cargas parciales de Mulliken obtenidas de cálculos HF/6-31G. La caracterización y clasificación de los tallos según estos descriptores mostró como la base diferenciadora tiene un comportamiento particular respecto a los demás nucleótidos del tallo y una fuerte influencia sobre el extremo CCA. La clasificación de nueve variaciones del tallo aceptor del tRNAAla mostró una buena relación estructura-actividad que pone en evidencia la bondad de los descriptores propuestos para caracterizar de manera local la distribución de carga de estas biomoléculas. 

  4. Bipolar magnetic semiconductor in silicene nanoribbons

    Energy Technology Data Exchange (ETDEWEB)

    Farghadan, Rouhollah, E-mail: rfarghadan@kashanu.ac.ir

    2017-08-01

    Highlights: • A new electronic phase for silicene nanoribbon in the presence of electric and magnetic fields. • Bipolar magnetic semiconductor with controllable spin-flip and spin-conserved gaps in silicene. • Robust bipolar magnetic semiconductor features in a rough silicene. • Perfect and reversible spin polarization in silicene nanoribbon junctions. - Abstract: A theoretical study was presented on generation of spin polarization in silicene nanoribbons using the single-band tight-binding approximation and the non-equilibrium Green’s function formalism. We focused on the effect of electric and exchange magnetic fields on the spin-filter capabilities of zigzag-edge silicene nanoribbons in the presence of the intrinsic spin-orbit interaction. The results show that a robust bipolar magnetic semiconductor with controllable spin-flip and spin-conserved gaps can be obtained when exchange magnetic and electric field strengths are both larger than the intrinsic spin-orbit interaction. Therefore, zigzag silicene nanoribbons could act as bipolar and perfect spin filter devices with a large spin-polarized current and a reversible spin polarization in the vicinity of the Fermi energy. We also investigated the effect of edge roughness and found that the bipolar magnetic semiconductor features are robust against edge disorder in silicene nanoribbon junctions. These results may be useful in multifunctional spin devices based on silicene nanoribbons.

  5. Family History in Patients with Bipolar Disorder.

    Science.gov (United States)

    Özdemir, Osman; Coşkun, Salih; Aktan Mutlu, Elif; Özdemir, Pınar Güzel; Atli, Abdullah; Yilmaz, Ekrem; Keskin, Sıddık

    2016-09-01

    In this study, we aimed to better understand the genetic transmission of bipolar disorder by examining the family history of patients. Sixty-three patients with bipolar disorder and their families were included. The final sample comprised 156 bipolar patients and their family members. An inclusion criterion was the presence of bipolar disorder history in the family. The diagnosis of other family members was confirmed by analyzing their files, hospital records, and by calling them to the hospital. Sixty-five patients were women (41.6%) and 91 were men (58.3%) (ratio of men/women: 1.40). When analyzing the results in terms of the transition of disease from the mother's or father's side, similar results were obtained: 25 patients were from the mother's side and 25 patients were from the father's side in 63 cases. The results of our study support the fact that a significant relationship exists between the degree of kinship and the heritability of bipolar disorder and, furthermore, that the effect of the maternal and paternal sides is similar on the transmission of genetic susceptibility.

  6. [Drug Abuse Comorbidity in Bipolar Disorder].

    Science.gov (United States)

    Ortiz, Óscar Medina

    2012-06-01

    Drug use among patients with bipolar disorder is greater than the one observed in the general population; psychotic episodes are likely to occur after consumption. This has implications in the prevention, etiology, management, and treatment of the disease. Bipolar disorder pathology is likely to have positive response to pharmacological treatment. Therefore, identifying the strategies with better results to be applied in these patients is fundamental for psychiatrists and primary care physicians. Review literature in order to determine the prevalence and characteristics of drug abuse in patients with bipolar disorder and establish the pharmacological strategies that have produced better results. Literature review. A great variety of studies demonstrate the relationship between bipolar disorder and drug use disorder. These patients are hospitalized more frequently, have an earlier onset of the disease, and present a larger number of depressive episodes and suicide attempts which affect the course of the disease. The drug with better results in the treatment of these patients is Divalproate. Satisfactory results have been also obtained with other mood stabilizers such as carbamazepine, lamotrigine, and the antipsychotic aripiprazole. Substance abuse is present in a large number of patients with bipolar disorder. The Divalproate is the drug that has shown better results in the studies. Copyright © 2012 Asociación Colombiana de Psiquiatría. Publicado por Elsevier España. All rights reserved.

  7. Bipolar magnetic semiconductor in silicene nanoribbons

    International Nuclear Information System (INIS)

    Farghadan, Rouhollah

    2017-01-01

    Highlights: • A new electronic phase for silicene nanoribbon in the presence of electric and magnetic fields. • Bipolar magnetic semiconductor with controllable spin-flip and spin-conserved gaps in silicene. • Robust bipolar magnetic semiconductor features in a rough silicene. • Perfect and reversible spin polarization in silicene nanoribbon junctions. - Abstract: A theoretical study was presented on generation of spin polarization in silicene nanoribbons using the single-band tight-binding approximation and the non-equilibrium Green’s function formalism. We focused on the effect of electric and exchange magnetic fields on the spin-filter capabilities of zigzag-edge silicene nanoribbons in the presence of the intrinsic spin-orbit interaction. The results show that a robust bipolar magnetic semiconductor with controllable spin-flip and spin-conserved gaps can be obtained when exchange magnetic and electric field strengths are both larger than the intrinsic spin-orbit interaction. Therefore, zigzag silicene nanoribbons could act as bipolar and perfect spin filter devices with a large spin-polarized current and a reversible spin polarization in the vicinity of the Fermi energy. We also investigated the effect of edge roughness and found that the bipolar magnetic semiconductor features are robust against edge disorder in silicene nanoribbon junctions. These results may be useful in multifunctional spin devices based on silicene nanoribbons.

  8. Comorbid medical illness in bipolar disorder.

    Science.gov (United States)

    Forty, Liz; Ulanova, Anna; Jones, Lisa; Jones, Ian; Gordon-Smith, Katherine; Fraser, Christine; Farmer, Anne; McGuffin, Peter; Lewis, Cathryn M; Hosang, Georgina M; Rivera, Margarita; Craddock, Nick

    2014-12-01

    Individuals with a mental health disorder appear to be at increased risk of medical illness. To examine rates of medical illnesses in patients with bipolar disorder (n = 1720) and to examine the clinical course of the bipolar illness according to lifetime medical illness burden. Participants recruited within the UK were asked about the lifetime occurrence of 20 medical illnesses, interviewed using the Schedules for Clinical Assessment in Neuropsychiatry (SCAN) and diagnosed according to DSM-IV criteria. We found significantly increased rates of several medical illnesses in our bipolar sample. A high medical illness burden was associated with a history of anxiety disorder, rapid cycling mood episodes, suicide attempts and mood episodes with a typically acute onset. Bipolar disorder is associated with high rates of medical illness. This comorbidity needs to be taken into account by services in order to improve outcomes for patients with bipolar disorder and also in research investigating the aetiology of affective disorder where shared biological pathways may play a role. Royal College of Psychiatrists.

  9. Rumination in bipolar disorder: evidence for an unquiet mind

    OpenAIRE

    Ghaznavi, Sharmin; Deckersbach, Thilo

    2012-01-01

    Abstract Depression in bipolar disorder has long been thought to be a state characterized by mental inactivity. However, recent research demonstrates that patients with bipolar disorder engage in rumination, a form of self-focused repetitive cognitive activity, in depressed as well as in manic states. While rumination has long been associated with depressed states in major depressive disorder, the finding that patients with bipolar disorder ruminate in manic states is unique to bipolar disord...

  10. Voltage regulator for battery power source. [using a bipolar transistor

    Science.gov (United States)

    Black, J. M. (Inventor)

    1979-01-01

    A bipolar transistor in series with the battery as the control element also in series with a zener diode and a resistor is used to maintain a predetermined voltage until the battery voltage decays to very nearly the predetermined voltage. A field effect transistor between the base of the bipolar transistor and a junction between the zener diode and resistor regulates base current of the bipolar transistor, thereby regulating the conductivity of the bipolar transistor for control of the output voltage.

  11. Algoritmo para el cálculo de cargas de trabajo

    Directory of Open Access Journals (Sweden)

    Mauricio Becerra Fernández

    2016-04-01

    Full Text Available Este artículo presenta el desarrollo un algoritmo para el cálculo de cargas de trabajo, soportado en el análisis de estudios similares y la teoría del estudio de métodos y tiempos. El algoritmo se propone como un elemento de soporte para el análisis del nivel trabajo asignado a un cargo específico o a un grupo de trabajadores en un área determinada, ya sea en la industria de manufactura o de servicios, lo que permita nivelar el volumen de trabajo asignado mediante la definición de diversas alternativas que promuevan el aumento de la productividad, favorezcan la mejora en el clima y las condiciones laborales.

  12. PLANIFICACIÓN JERÁRQUICA CON ANÁLISIS DE CARGA-CAPACIDAD

    Directory of Open Access Journals (Sweden)

    Tulio Gerardo Motoa

    2001-01-01

    Full Text Available

    La planificación jerárquica de múltiples proyectos, surge como una opción robusta y potente, para resolver el problema de gestión del sistema global. La propuesta se basa en la construcción de una estructura de descomposición-agregación de los proyectos y los recursos, con múltiples niveles, en la cual, los niveles más altos presentan los datos más agregados, con horizontes de tiempo más largos y los niveles inferiores son más detallados y con horizontes más cortos. Dentro del ámbito de la planificación jerárquica, el análisis de carga-capacidad pretende fundamentalmente mejorar la relación entre la oferta y la demanda de recursos en los procesos de planificación de proyectos, de tal manera que se garantice el cumplimiento de las fechas ya establecidas. Este análisis, se implementa midiendo algunos indicadores que reflejan el estado de la relación entre la carga y la capacidad y ejecutando un procedimiento de nivelación que avanza en el equilibrio de tal estado. El procedimiento de análisis se ha experimentado mediante un conjunto de proyectos generados aleatoriamente y los resultados son bastante buenos.

  13. Estimativa da carga do tabagismo no Brasil: mortalidade, morbidade e custos

    Directory of Open Access Journals (Sweden)

    Márcia Teixeira Pinto

    2015-06-01

    Full Text Available Os avanços no controle do tabagismo no Brasil podem ser verificados na redução da prevalência nas últimas duas décadas. As estatísticas de óbitos, ocorrência de eventos e custos diretos atribuíveis às doenças tabaco-relacionadas não são estimadas com frequência no país. O objetivo deste artigo foi estimar a carga do tabagismo em 2011, em termos de mortalidade, morbidade e custos da assistência médica das principais doenças tabaco-relacionadas. Desenvolveu-se um modelo econômico baseado em uma microssimulação probabilística de milhares de indivíduos através de coortes hipotéticas que considerou a história natural, os custos diretos em saúde e a qualidade de vida desses indivíduos. O tabagismo foi responsável por 147.072 óbitos, 2,69 milhões anos de vida perdidos, 157.126 infartos agudos do miocárdio, 75.663 acidentes vasculares cerebrais e 63.753 diagnósticos de câncer. O custo para o sistema de saúde foi de R$ 23,37 bilhões. O monitoramento da carga do tabagismo é uma importante estratégica para informar aos tomadores de decisão e fortalecer a política pública de saúde.

  14. Remoción de carga contaminante en aguas residuales industriales a escala de laboratorio

    Directory of Open Access Journals (Sweden)

    Gustavo Adolfo Peña-Hernandez

    2015-12-01

    Full Text Available El desarrollo industrial de un país se encuentra relacionado con el uso de sus recursos naturales, es por esto que se deben definir nuevas estrategias de remoción de carga contaminante para cumplir la nueva normatividad de usos de agua y vertimientos líquidos en Colombia. Una de estas alternativas es utilizar bacterias nativas productoras de biopolímero EPS y PHA sintetizadas en laboratorio. Esta investigación tuvo como objetivos determinar la relación que existe entre la producción de biopolímeros y la remoción de DBO5, DQO y SST en un reactor aerobio continuo y realizar la comparación de producción de EPS y PHA entre un reactor tipo batch y un reactor aerobio continuo, con efluentes de dos empresas del sector alimenticio de Manizales, Colombia. Se utilizó un sistema de biorreactores aerobios de flujo ascendente el cual se alimentó de forma continua por medio de tanques de suministro. En la empresa productora de golosinas los mayores valores de remoción fueron de 81,46%, 64,09% y 75,78% para DBO5, DQO y S.S.T respectivamente. Se obtuvieron biopolímeros EPS y PHA en mayor cantidad de 2,38 y 0,667 mg l-1 respectivamente. Por otro lado, el efluente de la empresa productora de derivados lácteos presentó fermentación de las aguas tratados en los biorreactores, caso que fue eliminado del estudio dada esta contaminación. En conclusión, se obtuvieron biopolímeros EPS y PHA en los tratamientos, a la vez que se evidenció la remoción de carga orgánica de las aguas tratadas.

  15. Family Functioning and the Course of Adolescent Bipolar Disorder

    Science.gov (United States)

    Sullivan, Aimee E.; Judd, Charles M.; Axelson, David A.; Miklowitz, David J.

    2012-01-01

    The symptoms of bipolar disorder affect and are affected by the functioning of family environments. Little is known, however, about the stability of family functioning among youth with bipolar disorder as they cycle in and out of mood episodes. This study examined family functioning and its relationship to symptoms of adolescent bipolar disorder,…

  16. Coping and personality in older patients with bipolar disorder

    NARCIS (Netherlands)

    Schouws, S.N.T.M.; Paans, N.P.G.; Comijs, H.C.; Dols, A.; Stek, M.L.

    2015-01-01

    Abstract Background Little is known about coping styles and personality traits in older bipolar patients. Adult bipolar patients show a passive coping style and higher neuroticism scores compared to the general population. Our aim is to investigate personality traits and coping in older bipolar

  17. Dealing with bipolar disorder in general practice | Rodseth | South ...

    African Journals Online (AJOL)

    ... it is in the general realm of specialist diagnosis and care, general practitioners can play an important role in early identification of the disorder and long-term management, in shared care with the psychiatrist. Keywords: bipolar disorder, mania, hypomania, depression, DSM-IV criteria, bipolar I disorder, bipolar II disorder ...

  18. Comparação de diferentes métodos de controle da carga interna em jogadores de voleibol

    Directory of Open Access Journals (Sweden)

    Maurício Gattás Bara Filho

    2013-04-01

    Full Text Available INTRODUÇÃO: A capacidade de monitorar precisamente a carga de treinamento é um importante aspecto para a efetividade da periodização e para a prevenção de efeitos negativos, como a queda no rendimento. OBJETIVOS: Comparar e correlacionar diferentes métodos de controle de carga interna de treinamento em jogadores de voleibol. MÉTODOS: Quinze atletas profissionais de voleibol do sexo masculino, com idade entre 18 e 30 anos, que competiam em níveis estaduais e nacionais, participaram deste estudo. A carga de treino para cada sessão foi calculada utilizando três diferentes métodos: PSE da Sessão, Zonas de FC (TRIMP de Edwards e de Stagno. RESULTADOS: Verificou-se que há correlação positiva e significativa entre o método proposto por Foster, Edwards e Stagno. No entanto, os valores das correlações individuais entre PSE e Edwards (0,451 a 0,670, em geral, foram ligeiramente maiores que os da correlação entre PSE e Stagno (0,206 a 0,597. CONCLUSÃO: O método proposto por Edwards, bem como o método proposto por Foster, melhor refletem as cargas de treino no voleibol, fazendo com que o monitoramento das cargas seja realizado de maneira mais fidedigna e confiável quando realizado por esses dois métodos.

  19. Concurrent hypokalemic periodic paralysis and bipolar disorder

    Directory of Open Access Journals (Sweden)

    Chia-Lin Lin

    2015-01-01

    Full Text Available Primary periodic paralysis is a rare autosomal dominant disorder of ion-channel dysfunction, manifested by episodic flaccid paresis secondary to abnormal sarcolemma excitability. Membrane destabilization involving Na, K-ATPase has been hypothesized to be a biological etiology of the bipolar disorder (BD and the mechanisms underlying lithium therapy have been linked to it. To date, there has been only one reported case of BD comorbid with periodic paralysis. Herein, we reported another case of concurrent bipolar mania and hypokalemic periodic paralysis (HPP, one special form of periodic paralysis. Consistent with the previous case, our patient responded well to lithium treatment for both bipolar mania and HPP. This might provide some support to the hypothesis that the therapeutic effects of lithium in both BD and HPP could be due to the correction of the underlying common pathophysiology.

  20. Paired structures and bipolar knowledge representation

    DEFF Research Database (Denmark)

    Montero, Javier; Bustince, Humberto; Franco, Camilo

    In this strictly positional paper we propose a general approach to bipolar knowledge representation, where the meaning of concepts can be modelled by examining their decomposition into opposite and neutral categories. In particular, it is the semantic relationship between the opposite categories...... which suggests the emergence of a paired structure and its associated type of neutrality, being there three general types of neutral categories, namely indeterminacy, ambivalence and conflict. Hence, the key issue consists in identifying the semantic opposition characterizing the meaning of concepts...... and at the same time the type of neutrality rising in between opposites. Based on this first level of bipolar knowledge representation, paired structures in fact offer the means to characterize a specific bipolar valuation scale depending on the meaning of the concept that has to be verified. In this sense...

  1. Fenomenologia do tempo vivido no transtorno bipolar

    Directory of Open Access Journals (Sweden)

    Virginia Moreira

    Full Text Available Com base na tradição da psicopatologia fenomenológica, este artigo se propõe a contribuir para a compreensão do mundo vivido do paciente bipolar, marcado por uma forte alteração do tempo vivido. Realizamos uma descrição deste tempo vivido significado de forma diferente nas oscilações de humor chamadas de fase maníaca e fase melancólica. Pensado a partir da temporalidade, na fase melancólica, o bipolar parece parar no tempo, não se lança em um devir. Na fase maníaca, o sujeito vive demasiadamente um agora como se tivesse explodido sua biografia. Concluímos que estas fases, ou dois pólos opostos no funcionamento temporal patológico do sofrimento bipolar, constituem fundamentalmente um mesmo mundo vivido.

  2. Genetic structure of personality factors and bipolar disorder in families segregating bipolar disorder.

    Science.gov (United States)

    Hare, Elizabeth; Contreras, Javier; Raventos, Henriette; Flores, Deborah; Jerez, Alvaro; Nicolini, Humberto; Ontiveros, Alfonso; Almasy, Laura; Escamilla, Michael

    2012-02-01

    Bipolar disorder (BPD) has been associated with variations in personality dimensions, but the nature of this relationship has been unclear. In this study, the heritabilities of BPD and the Big Five personality factors and the genetic correlations between BPD and personality factors are reported. The participants in this study were 1073 individuals from 172 families of Mexican or Central American ancestry. Heritabilities and genetic correlations were calculated under a polygenic model using the maximum-likelihood method of obtaining variance components implemented in the SOLAR software package. Heritabilities of 0.49, 0.43, and 0.43 were found for the narrowest phenotype (schizoaffective bipolar and bipolar I), the intermediate phenotype (schizoaffective bipolar, bipolar I, and bipolar II), and the broadest phenotype (schizoaffective bipolar, bipolar I, bipolar II, and recurrent depression), respectively. For the Big Five personality factors, heritabilities were 0.25 for agreeableness, 0.24 for conscientiousness, 0.24 for extraversion, 0.23 for neuroticism, and 0.32 for openness to experience. For the narrowest phenotype, a significant negative correlation (-0.32) with extraversion was found. For the broadest phenotype, negative correlations were found for agreeableness (-0.35), conscientiousness (-0.39), and extraversion (-0.44). A positive correlation (0.37) was found with neuroticism. It is not possible to determine whether aspects of personality are factors in the development of bipolar disorder or vice versa. The short form of the NEO does not provide the ability to examine in detail which facets of extraversion are most closely related to bipolar disorder or to compare our results with studies that have used the long version of the scale. This study establishes a partial genetic basis for the Big Five personality factors in this set of families, while the environmental variances demonstrate that non-genetic factors are also important in their influence on

  3. Systematic review of the prevalence of bipolar disorder and bipolar spectrum disorders in population-based studies

    OpenAIRE

    Dell'Aglio Jr.,José Caetano; Basso,Lissia Ana; Argimon,Irani Iracema de Lima; Arteche,Adriane

    2013-01-01

    This paper describes the findings of a systematic literature review aimed at providing an overview of the lifetime prevalence of bipolar disorder and bipolar spectrum disorders in population-based studies. Databases MEDLINE, ProQuest, Psychnet, and Web of Science were browsed for papers published in English between 1999 and May 2012 using the following search string: bipolar disorders OR bipolar spectrum disorders AND prevalence OR cross-sectional OR epidemiology AND population-based OR non-c...

  4. A five year follow-up study of 11 patients with bipolar disorder Seguimento de 11 pacientes com transtorno bipolar por cinco anos

    Directory of Open Access Journals (Sweden)

    Fernanda Novis

    2010-01-01

    Full Text Available OBJECTIVE: To study the long-term follow-up of patients with bipolar disorder (BPD. METHOD: Eleven outpatients with BPD type I were followed up naturalistically for five years at a university teaching hospital. The Clinical Global Impression Scale (BPD version was used to evaluate the occurrence of affective episodes, and the Strauss-Carpenter Outcome Scale was used to evaluate social and occupational functioning. RESULTS: The majority of patients were symptomatic most of the time, with predominantly depressive episodes. Overall, patients remained euthymic a mean of 47.7% of the time. Despite a low rate of hospitalization, social and occupational functioning was poor in the majority of patients. A poor disease course with respect to work-related functioning was associated with fewer months of euthymia with a longer duration of depressive episodes. The total number of months of euthymia negatively correlated with the patient's age and disease duration. CONCLUSION: Despite the small sample size, the present findings appear to corroborate previous studies on the evolution of BPD. Most of the patients had a poor disease course, with long symptomatic periods, particularly depressive episodes, and significantly impaired social and occupational functioning.OBJETIVO: Estudar a evolução de longo prazo do transtorno bipolar (TB. MÉTODO: Onze pacientes com TB do tipo I foram acompanhados de forma naturalística em um ambulatório universitário por cinco anos. Foram utilizadas a Escala de Impressão Clínica Global (versão TB, para a avaliação dos episódios afetivos, e a Escala de Evolução Strauss-Carpenter, para a avaliação do funcionamento sócio-ocupacional. RESULTADOS: A maioria dos pacientes esteve sintomática a maior parte do tempo, apresentando predominantemente quadros depressivos. Em média, os pacientes ficaram em eutimia durante 47,7% do tempo. Apesar do baixo índice de hospitalização, a maioria dos pacientes apresentou

  5. Exercise in bipolar patients: A systematic review.

    Science.gov (United States)

    Melo, Matias Carvalho Aguiar; Daher, Elizabeth De Francesco; Albuquerque, Saulo Giovanni Castor; de Bruin, Veralice Meireles Sales

    2016-07-01

    Sedentary lifestyle is frequent in psychiatric disorders, however the directions of this association and benefits of physical activity are unclear. This is a systematic review about exercise in patients with bipolar disorder. We performed a systematic literature search of studies published in English (1995 Jan to 2016 Jan) in PubMed, and Cochrane Library combining the medical terms 'physical activity' or 'sedentary' or 'physical exercise' with 'bipolar disorder' or 'mania' or 'bipolar depression'. Thirty-one studies were selected and included 15,587 patients with bipolar disorder. Sedentary lifestyle varied from 40% to 64.9%. Physical activity was associated with less depressive symptoms, better quality of life and increased functioning. Some evidence indicates a relationship between vigorous exercises and mania. Three prospective cohorts were reported; and no prospective randomized controlled trial was identified. Three studies focused on biomarkers in bipolar patients; and one reported the relationship between exercise and sleep in this group. Two assessed physical exercise in adolescents. (1) Differences between studies preventing a unified analysis; (2) most studies were cross-sectional; (3) motivation for exercising is a selection bias in most studies; (4) no intervention study assessing only physical exercise; (5) lack of studies comparing exercise across mood states. Generally, exercise was associated with improved health measures including depressive symptoms, functioning and quality of life. Evidence was insufficient to establish a cause-effect relationship between mood and physical exercise. Future research including randomized trials is needed to clarify the role of physical activity in bipolar patients. Copyright © 2016 Elsevier B.V. All rights reserved.

  6. A report on older-age bipolar disorder from the International Society for Bipolar Disorders Task Force

    DEFF Research Database (Denmark)

    Sajatovic, Martha; Strejilevich, Sergio A; Gildengers, Ariel G

    2015-01-01

    OBJECTIVES: In the coming generation, older adults with bipolar disorder (BD) will increase in absolute numbers as well as proportion of the general population. This is the first report of the International Society for Bipolar Disorder (ISBD) Task Force on Older-Age Bipolar Disorder (OABD). METHO...

  7. Three times more days depressed than manic or hypomanic in both bipolar I and bipolar II disorder

    NARCIS (Netherlands)

    Kupka, Ralph W.; Altshuler, Lori L.; Nolen, Willem A.; Suppes, Trisha; Luckenbaugh, David A.; Leverich, Gabriele S.; Frye, Mark A.; Keck, Paul E.; McElroy, Susan L.; Grunze, Heinz; Post, Robert M.

    Objectives: To assess the proportion of time spent in mania, depression and euthymia in a large cohort of bipolar subjects studied longitudinally, and to investigate depression/mania ratios in patients with bipolar I versus bipolar II disorder. Methods: Clinician-adjusted self-ratings of mood were

  8. Alcoholism and anxiety in bipolar illness : Differential lifetime anxiety comorbidity in bipolar I women with and without alcoholism

    NARCIS (Netherlands)

    Levander, Eric; Frye, Mark A.; McElroy, Susan; Suppes, Trisha; Grunze, Heinz; Nolen, Willem A.; Kupka, Ralph; Keck, Paul E.; Leverich, Gabriele S.; Altshuler, Lori L.; Hwang, Sun; Mintz, Jim; Post, Robert M.

    Introduction: This study was undertaken to evaluate the prevalence rate of anxiety comorbidity in bipolar subjects with and without alcohol use disorders (AUD). Methods: Bipolar men and women who entered the Stanley Foundation Bipolar Network (SFBN) underwent a Structured Clinical Interview for

  9. Estudio de la frecuencia en la deformación en condiciones edométricas de un suelo compactado sometido a carga cíclica

    OpenAIRE

    Persia Melissa, Castillo Aristy

    2014-01-01

    A lo largo de los años se ha estudiado la carga dinámica que provocan los sismos en el suelo durante la ocurrencia de un evento de esta naturaleza, sin embargo los sismos no son los únicos eventos que provocan en el suelo cargas de este tipo. Actividades antrópicas también se relacionan con la generación de vibraciones que provocan en el suelo cargas de tipo cíclica, paso de vehículos sobre una carretera o de un tren de alta velocidad sobre los rieles, entre otros eventos, prov...

  10. Transitórios em rejeição de carga envolvendo linhas de transmissão e motores assíncronos.

    OpenAIRE

    Adriana Yineth Montero Cruz

    2009-01-01

    Apesar do grande interesse no comportamento dinâmico das cargas, existe uma lacuna em investigações considerando o seu desempenho transitório, quando alimentadas por linhas de transmissão e a rejeição de carga ocorre com a abertura dos disjuntores do lado fonte, causando sobretensões temporárias. Este trabalho analisa as sobretensões temporárias causadas por este evento em uma carga de grande porte, constituída por motores síncronos e assíncronos, que pode operar parte do tempo somente com mo...

  11. BIPOLAR DISORDER AND METABOLIC SYNDROME: COMORBIDITY OR SIDE EFFECTS OF TREATMENT OF BIPOLAR DISORDER

    OpenAIRE

    Babić, Dragan; Maslov, Boris; Nikolić, Katica; Martinac, Marko; Uzun, Suzana; Kozumplik, Oliver

    2010-01-01

    Objective: There is evidence that people with mental disorders are more likely to suffer from metabolic syndrome. In the last decades there has been an increase in interest for researching metabolic syndrome in psychiatric patients and plenty of evidence about their association. However, investigations on the prevalence of metabolic syndrome in patients with bipolar disorder are still surprisingly rare. The aim of this paper is to analyze comorbidity of bipolar disorder and metabolic syndrome...

  12. Nuevo modelo matemático para la distribución de carga en el horno alto

    Directory of Open Access Journals (Sweden)

    Jiménez, J.

    1998-05-01

    Full Text Available A mathematical model for burden distribution in the blast furnace, has been developed. A set of operational variables related with the charging system (Paul Wurth plus other parameters related with the burden itself, such as ore and coke repose angles, weights discharged and the effect of the uprising gas, have been taken into account. These data are processed by modern computer tools. As a result, the burden distribution inside the blast furnace is obtained. Every time that a charge is added to the blast furnace, the model updates the burden distribution. The approach employed is based on considering each burden layer described by a set of interrelated polynomials. It has been tested comparing its results with burden layers obtained in a physical model of the blast furnace (scale 1/10. After installation in Aceralia blast furnace B control computers, the model is currently being employed as a tool for process control.

    El modelo matemático desarrollado describe la distribución de carga en el tragante de un horno alto. Se ha empleado un conjunto de variables operacionales relacionadas con el sistema de carga (Paul Wurth, junto con otras obtenidas de la carga, tales como el peso descargado, los ángulos de reposo de los materiales y el efecto del gas al atravesar el horno. Estos datos se procesan mediante herramientas informáticas. Como resultado, se obtiene la distribución de carga en el horno. Cada vez que se introduce una carga, el modelo actualiza la distribución. La aproximación empleada considera el perfil de cada capa de carga, el cual está descrito por un conjunto de polinomios interrelacionados. Los resultados se comparan con la distribución obtenida en un modelo físico del horno (escala 1/10. Tras su instalación en los ordenadores de proceso del horno alto B de Aceralia, el modelo se emplea actualmente para el control del mismo.

  13. Unblending Borderline Personality and Bipolar Disorders.

    Science.gov (United States)

    di Giacomo, Ester; Aspesi, Flora; Fotiadou, Maria; Arntz, Arnoud; Aguglia, Eugenio; Barone, Lavinia; Bellino, Silvio; Carpiniello, Bernardo; Colmegna, Fabrizia; Lazzari, Marina; Lorettu, Liliana; Pinna, Federica; Sicaro, Aldo; Signorelli, Maria Salvina; Clerici, Massimo

    2017-08-01

    Borderline Personality (BPD) and Bipolar (BP) disorders stimulate an academic debate between their distinction and the inclusion of Borderline in the Bipolar spectrum. Opponents to this inclusion attribute the important differences and possible diagnostic incomprehension to overlapping symptoms. We tested 248 Borderline and 113 Bipolar patients, consecutively admitted to the Psychiatric Unit, through DSM-IV Axis I and II Disorders (SCID-I/II), Hamilton Depression Rating Scale (HAM-D), Hamilton Anxiety Rating Scale (HAM-A), Young Mania Rating Scale (YMRS) and Borderline Personality Disorder Severity Index-IV (BPDSI-IV). All the tests statistically discriminated the disorders (p Borderline patients with manic features offer a privileged point of view for a deeper analysis. This allows for the possibility of a more precise examination of the nature and load of each symptom. Borderline Personality and Bipolar Disorders can be distinguished with high precision using common and time-sparing tests. The importance of discriminating these clinical features may benefit from this evidence. Copyright © 2017. Published by Elsevier Ltd.

  14. Bipolar disorder: Evidence for a major locus

    Energy Technology Data Exchange (ETDEWEB)

    Spence, M.A.; Flodman, P.L. [Univ. of California, Irvine, CA (United States); Sadovnick, A.D.; Ameli, H. [Univ. of British Columbia, Vancouver (Canada)] [and others

    1995-10-09

    Complex segregation analyses were conducted on families of bipolar I and bipolar II probands to delineate the mode of inheritance. The probands were ascertained from consecutive referrals to the Mood Disorder Service, University Hospital, University of British Columbia and diagnosed by DSM-III-R and Research Diagnostic Criteria. Data were available on over 1,500 first-degree relatives of the 186 Caucasian probands. The purpose of the analyses was to determine if, after correcting for age and birth cohort, there was evidence for a single major locus. Five models were fit to the data using the statistical package SAGE: (1) dominant, (2) recessive, (3) arbitrary mendelian inheritance, (4) environmental, and (5) no major effects. A single dominant, mendelian major locus was the best fitting of these models for the sample of bipolar I and II probands when only bipolar relatives were defined as affected (polygenic inheritance could not be tested). Adding recurrent major depression to the diagnosis {open_quotes}affected{close_quotes} for relatives reduced the evidence for a major locus effect. Our findings support the undertaking of linkage studies and are consistent with the analyses of the National Institutes of Mental Health (NIMH) Collaborative Study data by Rice et al. and Blangero and Elston. 39 refs., 4 tabs.

  15. Comorbidity of bipolar disorder and eating disorders.

    Science.gov (United States)

    Álvarez Ruiz, Eva M; Gutiérrez-Rojas, Luis

    2015-01-01

    The comorbidity of bipolar disorder and eating disorders has not been studied in depth. In addition, clinical implications involved in the appearance of both disorders are very important. A systematic literature review of MEDLINE published up to September 2013 was performed, analyzing all the articles that studied the comorbidity of both conditions (bipolar disorder and eating disorders) and others research that studied the efficacy of pharmacological treatment and psychotherapy to improve these illnesses. In this review we found a high comorbidity of bipolar disorder and eating disorders, especially of bulimia nervosa and binge eating disorder. Studies show that lithium and topiramate are 2 of the more effective pharmacological agents in the treatment of both disorders. There are a lot of studies that show evidence of comorbidity of bipolar disorder and eating disorders. However, further research is needed on assessment and treatment when these conditions co-exist, as well as study into the biopsychological aspects to determine the comorbid aetiology. Copyright © 2014 SEP y SEPB. Published by Elsevier España. All rights reserved.

  16. Radiation Damage In Advanced Bipolar Transistors

    Science.gov (United States)

    Zoutendyk, John A.; Goben, Charles A.; Berndt, Dale F.

    1989-01-01

    Report describes measurements of common-emitter current gains (hFE) of advanced bipolar silicon transistors before, during, and after irradiation with 275-MeV bromine ions, 2.5-MeV electrons, and conductivity rays from cobalt-60 atoms.

  17. Facial affect recognition deficits in bipolar disorder.

    Science.gov (United States)

    Getz, Glen E; Shear, Paula K; Strakowski, Stephen M

    2003-05-01

    Patients diagnosed with bipolar disorder (BPD), by definition, have problems with emotional regulation. However, it remains uncertain whether these patients are also deficient at processing other people's emotions, particularly while manic. The present study examined the ability of 25 manic bipolar patients and 25 healthy participants on tasks of facial recognition and facial affect recognition at three different presentation durations: 500 ms, 750 ms, and 1000 ms. The groups did not differ in terms of age, education, sex, ethnicity, or estimated IQ. The groups did not differ significantly on either a novel computerized facial recognition task or the Benton Facial Recognition Test. In contrast, the bipolar group performed significantly more poorly than did the comparison group on a novel facial affect labeling task. Although the patient group had slower reaction times on all 3 computerized tasks, the presentation duration did not have an effect on performance in the patients. This study suggests that patients with bipolar disorder are able to recognize faces, but have difficulty processing facial affective cues.

  18. Heart rate variability in bipolar disorder

    DEFF Research Database (Denmark)

    Faurholt-Jepsen, Maria; Kessing, Lars Vedel; Munkholm, Klaus

    2017-01-01

    Background Heart rate variability (HRV) has been suggested reduced in bipolar disorder (BD) compared with healthy individuals (HC). This meta-analysis investigated: HRV differences in BD compared with HC, major depressive disorder or schizophrenia; HRV differences between affective states; HRV...

  19. Bipolarity and Ambivalence in Landscape Architecture

    NARCIS (Netherlands)

    Koh, J.

    2010-01-01

    Our discipline of landscape architecture contains bipolarity, not only in terms of landscape and architecture but also because the idea of landscape is both aesthetic and scientific. Furthermore, within landscape architecture there is a gap between design (as implied by architecture) and planning

  20. Oxide bipolar electronics: materials, devices and circuits

    Science.gov (United States)

    Grundmann, Marius; Klüpfel, Fabian; Karsthof, Robert; Schlupp, Peter; Schein, Friedrich-Leonhard; Splith, Daniel; Yang, Chang; Bitter, Sofie; von Wenckstern, Holger

    2016-06-01

    We present the history of, and the latest progress in, the field of bipolar oxide thin film devices. As such we consider primarily pn-junctions in which at least one of the materials is a metal oxide semiconductor. A wide range of n-type and p-type oxides has been explored for the formation of such bipolar diodes. Since most oxide semiconductors are unipolar, challenges and opportunities exist with regard to the formation of heterojunction diodes and band lineups. Recently, various approaches have led to devices with high rectification, namely p-type ZnCo2O4 and NiO on n-type ZnO and amorphous zinc-tin-oxide. Subsequent bipolar devices and applications such as photodetectors, solar cells, junction field-effect transistors and integrated circuits like inverters and ring oscillators are discussed. The tremendous progress shows that bipolar oxide electronics has evolved from the exploration of various materials and heterostructures to the demonstration of functioning integrated circuits. Therefore a viable, facile and high performance technology is ready for further exploitation and performance optimization.

  1. El sistema de transporte de carga en la Ciudad de México. Factores a considerar en el análisis del transporte de carga y la movilidad de mercancías

    OpenAIRE

    Floriu00E1n Rosa Martu00EDnez Perdomo

    2009-01-01

    El artículo presenta un análisis del sistema de transporte de carga en la Ciudad de México desde el punto de vista sistémico, considerando las variables económicas, políticas, técnicas, sociales que permitan comprender la problemática que actualmente enfrenta esta ciudad en la movilidad de mercancías. Es una reflexión de carácter multidisciplinario basada en el método cualitativo para explicar y comprender la situación actual del transporte de carga en México dentro del contexto de la globali...

  2. Herramienta para la evaluación del riesgo de robo en el autotransporte de carga

    Directory of Open Access Journals (Sweden)

    Elizabeth De la Torre

    2014-01-01

    Full Text Available Introducción: En México el robo se ha convertido en uno de los riesgos más importantes para la eficiencia y la competitividad de las cadenas de suministro. Esta propuesta busca identificar las variables que influyen sobre el riesgo de robo en el autotransporte como paso previo de una metodología para evaluar cuantitativamente la influencia de las variables identificadas y crear una aplicación que permita evaluar el riesgo de robo, apoyando así a la toma de decisiones en la creación de esquemas de seguridad. Metodología: El proceso para identificar estas variables de riesgo fue el análisis estadístico de la información disponible de robos de carga mediante el método de Análisis de Componentes Principales, determinando un primer conjunto de variables de interés para el diseño de una encuesta que se aplicó a expertos en seguridad de la cadena de suministro empleando la metodología Delphi y estableciendo ponderaciones a través del Proceso de Jerarquización Analítica. Resultados: Con la metodología propuesta se obtuvieron los factores más relevantes en el riesgo de robo en el autotransporte y se construyó una función para obtener un índice del riesgo. La función propuesta se programó en una aplicación computacional que facilita el cálculo del indicador propuesto con información de pares origen-destino determinados. Los resultados de la metodología permitirán confirmar las variables usadas o identificar nuevas variables considerando las cuantificaciones de su influencia en el riesgo. Discusión y Conclusión: Obtener información confiable sobre robos de carga es muy difícil, por lo sensible del tema y la inexactitud de los datos publicados. Estas imprecisiones y las percepciones subjetivas asociadas se atenúan con esta metodología basada en opiniones de expertos y en las técnicas cuantitativas referidas para integrar el índice de riesgo propuesto. Este índice permite dimensionar y comparar estrategias de

  3. Funciones de costos internos y externos en un modelo estratégico de transporte de carga

    Directory of Open Access Journals (Sweden)

    Luis Gabriel Márquez Díaz

    2010-11-01

    Full Text Available Se revisan las funciones de costos internos y externos,con fines de modelación estratégica del transportede carga. Se estudian el costo interno del tiempo, elcosto interno de operación y cinco componentes delcosto externo: costo externo de la congestión, costoexterno de los accidentes, costos de la polución delaire, costo del cambio climático y costo externo dela infraestructura; a partir de estos se deriva la funciónde costo marginal total. Se encuentra que es posibleestimar de forma empírica los parámetros de lasfunciones aplicables al transporte de cargainterregional en Colombia en los modos de transportecarretero, ferroviario y fluvial, y con ellos estudiarlos costos marginales sobre una red estratégica detransporte de carga.

  4. Carga viral para citomegalovirus, en líquido de lavado bronquioalveolar, en población pediátrica

    OpenAIRE

    B H Aristizabal-Bernal; O L Rincón-Caballero; MA Cano-Romero

    2017-01-01

    INTRODUCCIÓN: las infecciones pulmonares son comunes en los pacientes inmunocomprometidos. La carga viral de citomegalovirus se utiliza de rutina para determinar en qué momento se debe iniciar la terapia preventiva en hospederos inmunocomprometidos, diagnosticar enfermedad activa y supervisar la repuesta a una terapia implementada.   OBJETIVO: describir el valor de la carga viral de citomegalovirus en líquido de lavado bronquioalveolar vs. sangre periférica en población pediátrica con...

  5. A DECISÃO DO SUPERIOR TRIBUNAL DE JUSTIÇA SOBRE ABANDONO AFETIVO E A COLONIZAÇÃO DO MUNDO DA VIDA -- THE SUPERIOR COURT OF JUSTICE DECISION ABOUT EMOTIONAL DISTRESS AND THE LIFEWORLD COLONIZATION

    Directory of Open Access Journals (Sweden)

    Rachel Barros Nigro

    2016-06-01

    Full Text Available Resumo: Usando como referência alguns conceitos do filósofo alemão Jürgen Habermas, neste artigo busca-se analisar a decisão do Superior Tribunal de Justiça de acatar pedido de indenização por dano moral de abandono afetivo. A partir de uma breve explanação sobre a evolução do conceito de dano moral no Direito Civil brasileiro e de seu reflexo nos Tribunais Superiores, com a decisão pioneira da Ministra Nancy Andrighi, o texto traz à baila um fenômeno mais profundo: o novo papel do Direito nas sociedades plurais contemporâneas. Com base no marco teórico do direito civil-constitucional, aponta-se para uma expansão qualitativa da responsabilidade civil, derrubando barreiras entre o campo da Moral e do Direito e problematizando as tradicionais fronteiras entre a responsabilidade jurídica e a responsabilidade moral. Nesse sentido, propõe-se uma reflexão filosófica sobre a decisão, utilizando-se como referência a noção de “colonização do mundo da vida”, desenvolvida por Jürgen Habermas, a qual também evoluiu na obra do filósofo e que talvez não sirva mais como parâmetro para limitar a expansão da responsabilidade civil extra-contratual – direito de danos – a campos antes imunes à juridificação. Palavras-chave: Jurisprudência. Danos morais. Abandono afetivo. Colonização do mundo da vida. Jürgen Habermas.

  6. The relationship between borderline personality disorder and bipolar disorder

    Science.gov (United States)

    Zimmerman, Mark; Morgan, Theresa A.

    2013-01-01

    It is clinically important to recognize both bipolar disorder and borderline personality disorder (BPD) in patients seeking treatment for depression, and it is important to distinguish between the two. Research considering whether BPD should be considered part of a bipolar spectrum reaches differing conclusions. We reviewed the most studied question on the relationship between BPD and bipolar disorder: their diagnostic concordance. Across studies, approximately 10% of patients with BPD had bipolar I disorder and another 10% had bipolar II disorder. Likewise, approximately 20% of bipolar II patients were diagnosed with BPD, though only 10% of bipolar I patients were diagnosed with BPD. While the comorbidity rates are substantial, each disorder is nontheless diagnosed in the absence of the other in the vast majority of cases (80% to 90%). In studies examining personality disorders broadly, other personality disorders were more commonly diagnosed in bipolar patients than was BPD. Likewise, the converse is also true: other axis I disorders such as major depression, substance abuse, and post-traumatic stress disorder are also more commonly diagnosed in patients with BPD than is bipolar disorder. These findings challenge the notion that BPD is part of the bipolar spectrum. PMID:24174890

  7. Sleep study in Disruptive Mood Dysregulation Disorder and Bipolar children.

    Science.gov (United States)

    Estrada-Prat, Xavier; Álvarez-Guerrico, Ion; Bleda-Hernández, María J; Camprodon-Rosanas, Ester; Batlle-Vila, Santiago; Pujals-Altes, Elena; Nascimento-Osorio, María T; Martín-López, Luís M; Álvarez-Martínez, Enric; Pérez-Solá, Víctor; Romero-Cela, Soledad

    2017-01-01

    Decreased need for sleep has been proposed as a core symptom of mania and it has been associated with the pathogenesis of Bipolar Disorder. The emergence of Disruptive Mood Dysregulation Disorder (DMDD) as a new diagnostic has been controversial and much has been speculated about its relationship with the bipolar spectrum. REM sleep fragmentation could be a biomarker of affective disorders and it would help us to differentiate them from other disorders. Polysomnographic cross-sectional study of children with DMDD, bipolar disorder and Attention Deficit Hyperactivity Disorder (ADHD). All participants underwent a psychiatric semi-structured interview to obtain the diagnosis, comorbidities and primary sleep disorders. DMDD’s sample was performed following DSM5 criteria. Perform polysomnography in a sample of bipolar, DMDD and ADHD children and compare their profiles to provide more evidence about the differences or similarities between bipolar disorder and DMDD. Bipolar group had the highest REM density values while ADHD had the lowest. REM density was not statiscally different between bipolar phenotypes. REM density was associated with antidepressant treatment, episodes of REM and their interaction. REM latency was associated with antipsychotic treatment and school performance. Bipolar patients had higher scores on the depression scale than DMDD and ADHD groups. No significant differences between the two compared affective disorders were found. However there were differences in REM density between bipolar and ADHD groups. REM sleep study could provide a new theoretical framework to better understand the pathogenesis of pediatric bipolar disorder.

  8. DIGESTIÓN ANAEROBIA DE LACTOSUERO: EFECTO DE ALTAS CARGAS PUNTUALES ANAEROBIC DIGESTION OF WHEY: EFFECT OF HIGH POINT LOADS

    Directory of Open Access Journals (Sweden)

    Ricardo Adolfo Parra Huertas

    2010-06-01

    Full Text Available La tecnología de tratamiento anaeróbico se ha desarrollado para el tratamiento de aguas residuales principalmente de origen alimentario. El trabajo tuvo como objetivo determinar el comportamiento del sistema de depuración anaerobio cuando se incorporaban altas cargas puntuales de lactosuero. Se utilizó lactosuero ácido el cual alimentaba un sistema de dos etapas, biofiltro anaerobio y reactor UASB. Se manejaron 3 cargas constantes de 5,200 mg DQO/L.día, 7,800 mg DQO/L.día y 10.500 mg DQO/L.día; en cada carga se aplicaron 3 cargas puntuales de lactosuero ácido: 5,700 mg DQO/L.día, 26,300 mg DQO/L.día y 34.200 mg DQO/L.día, cada una con una duración de 24 horas. El tiempo de retención hidráulico del sistema fue 2,9 días; el valor del pH para la influente de las cargas puntuales y constantes fue de 7,0 previamente añadiéndose bicarbonato de sodio, para la efluente, el pH en las cargas constantes fue 7,6 y 7,7 para las cargas puntuales. La temperatura de operación se mantuvo en un intervalo de 15-20 °C. En las cargas constantes (CC la eliminación de DQO fue 57% y en las cargas puntuales (CP 82%. En azúcares la eficiencia fue 99% en las CC y CP. En proteína la eliminación fue 64% para las CC y CP 89%. Los ácidos grasos volátiles en las CC tuvieron una concentración de 403 mg/L en el influente y en efluente una concentración de 3.156 mg/L, en las CP la influente presentó concentración de 572 mg/L y para el efluente 4.492 mg/L. El sistema de dos etapas soportó las cargas puntuales hasta 6,5 veces la carga constante sin disminuir sus eficiencias, por el contrario las eficiencias en las variable respuesta estuvieron por encima de las cargas orgánicas constantes, observándose que el sistema propuesto es una buena opción para el tratamiento de agua residual con lactosuero pudiendo soportar descargas de lactosuero puro, por lo que puede ser recomendado a los productores de queso.Anaerobic treatment technology was developed

  9. Efeito das variações de temperatura na transferência de cargas em juntas de pavimentos de concreto

    Directory of Open Access Journals (Sweden)

    G. M. Colim

    Full Text Available Medidas de deflexões com o falling weight deflectometer permitiram a avaliação do comportamento de juntas em pavimentos de concreto simples do ponto de vista de sua eficiência de transferência de cargas (LTE. As investigações mostraram importantes variações nesse parâmetro, quando não há dispositivos de transferência de cargas, entre horários de dias bem como entre estações climáticas distintas (inverno e verão; enquanto que juntas com barras de transferência apresentam, pouca variação nesse parâmetro e encontrando-se em geral entre 90 e 100% de capacidade de transferência, quando há quedas de temperatura, as juntas sem barras chegam a apresentar capacidade de transferência reduzida para 50% no inverno e para 60% no verão. Valores estimados de transferência de carga com um programa de elementos finitos permitiram confirmar a necessidade de tratamento teórico do problema em fases de análise estrutural e projetos de pavimentos de concreto com juntas.

  10. Análise da carga de trabalho de analistas de sistemas e dos distúrbios osteomusculares

    Directory of Open Access Journals (Sweden)

    Bruno Maia de Guimarães

    Full Text Available OBJETIVOS: O objetivo desta pesquisa foi realizar avaliação das condições ergonômicas de analistas de sistemas, com a finalidade de conhecer os fatores geradores de sobrecargas físicas e cognitivas, suas repercussões sobre os trabalhadores e propor melhorias para a diminuição dessas sobrecargas. METODOLOGIA: Foram utilizados o método SHTM (sistema homem-tarefa-máquina de avaliação ergonômica; o diagrama de Corlett, para a avaliação do desconforto corporal; o questionário de avaliação do mobiliário; e o NASA-TLX, para a avaliação de carga mental de trabalho. RESULTADOS: Foram encontradas as prevalências de dor na coluna lombar (71% e na coluna cervical (64% dos entrevistados. Após a avaliação da carga mental de trabalho, foi observado que a demanda mental foi a mais exigida entre os analistas de sistemas e a média da carga global foi de 13,23. CONCLUSÃO: Pode-se concluir que a alta prevalência de dor musculoesquelética pode ser causada pela presença de mobiliário inadequado, pela adoção de posturas incorretas e pela alta exigência mental das atividades desenvolvidas.

  11. Determinação de cargas elétricas em solos Determination of electric charges in soils

    Directory of Open Access Journals (Sweden)

    Bernardo van Raij

    1973-01-01

    Full Text Available As cargas elétricas dos solos estudados variaram em função da concentração da solução, do pH e da valência dos íons trocáveis. Optou-se pela determinação das cargas em condições de equilíbrio relativamente a pH e concentração da solução, omitindo-se uma lavagem total do excesso de solução salina. Cargas positivas e negativas variaram com o sal empregado, para amostras do horizonte B2 de um Latossolo Roxo e de uma Terra Roxa Estruturada, aumentando na ordem NaClElectric charges of soils were shown to vary with concentration and pH of the equilibrium solution and with the valence of the counter-ions. Accordingly, in determining the electric charges of soils, total removal of excess electrolyte should be avoided and charges should be determined by measuring ion uptake under equilibrium conditions with respect to concentration and pH. For given values of pH and electrolyte concentration, positive and negative charges determined with different salts for an Oxisol (Latossolo Roxo and an Alfisol (Terra Roxa Estruturada, increased in the order NaCl

  12. PERDIDA DE CARGA EN CONDUCTOS DE HIERRO GALVANIZADO CONDUCIENDO AGUA RESIDUAL DE INSTALACIONES DE GALLINAS PONEDORAS

    Directory of Open Access Journals (Sweden)

    JOSÉ ANTONIO RODRIGUES DE SOUZA

    2011-01-01

    Full Text Available Las operaciones relacionadas con la producción de aves de corral pueden generar efluentes procedentes de fuentes distintas, incluida la escorrentía originada en las jaulas, alimentación y abastecimiento de agua de las aves y de las instalaciones de almacenamiento y manejo de residuos. En todo proyecto de explotación de aves de corral, se debe tener en cuenta el manejo de residuos y aguas residuales, las cuales pueden ser conducidas en tuberías de hierro galvanizado. El objetivo de este trabajo, fue el ajustar ecuaciones para estimar la perdida de carga continua en conductos de hierro galvanizado en los diámetros comerciales, variando de 50 a 150 mm, operando con agua residual de gallinas ponedoras en diferentes concentraciones de sólidos totales. Los resultados indicaron que las metodologías de Duffy & Titchener y HazenWilliams modificadas presentaron ajustes cuyo coeficiente de determinación fue superior a 0,95, por lo que es considerado apropiado para el dimensionamiento de proyectos hidráulicos.

  13. PERIODIZAÇÃO E EVOLUÇÃO DA LOGÍSTICA URBANA DE CARGAS

    Directory of Open Access Journals (Sweden)

    Fander de Oliveira Silva

    2017-08-01

    La Logística ha tenido una evolución continua en el espacio urbano y no su concepto funcional. A lo largo de su desarrollo llegó a ser considerada una de los principales puntos estratégicos del sistema de producción integrada, que incorpora innovaciones y genera otras en relación con el concepto actual de Gestión de la Cadena de Suministro. El objetivo principal de este trabajo lleva a entender la forma en que la logística urbana se desarrolla en Brasil, que a pesar de haber surgido tarde, en comparación con otros países, ha desarrollado una estructura capaz de alimentar los circuitos espaciales productivos y, por otra parte, se ha convertido en un elemento importante en la reorganización del territorio brasileño, ocupando posiciones destacadas en la composición de los presupuestos públicos y privados. Palabras clave: Logística; Carga Urbana; Geografia dos Transportes.

  14. Systematic review of the prevalence of bipolar disorder and bipolar spectrum disorders in population-based studies.

    Science.gov (United States)

    Dell'Aglio, José Caetano; Basso, Lissia Ana; Argimon, Irani Iracema de Lima; Arteche, Adriane

    2013-01-01

    This paper describes the findings of a systematic literature review aimed at providing an overview of the lifetime prevalence of bipolar disorder and bipolar spectrum disorders in population-based studies. Databases MEDLINE, ProQuest, Psychnet, and Web of Science were browsed for papers published in English between 1999 and May 2012 using the following search string: bipolar disorders OR bipolar spectrum disorders AND prevalence OR cross-sectional OR epidemiology AND population-based OR non-clinical OR community based. The search yielded a total of 434 papers, but only those published in peer-reviewed journals and with samples aged ≥ 18 years were included, resulting in a final sample of 18 papers. Results revealed rather heterogeneous findings concerning the prevalence of bipolar disorders and bipolar spectrum disorders. Lifetime prevalence of bipolar disorder ranged from 0.1 to 7.5%, whereas lifetime prevalence of bipolar spectrum disorders ranged from 2.4 to 15.1%. Differences in the rates of bipolar disorder and bipolar spectrum disorders may be related to the consideration of subthreshold criteria upon diagnosis. Differences in the prevalence of different subtypes of the disorder are discussed in light of diagnostic criteria and instruments applied.

  15. Systematic review of the prevalence of bipolar disorder and bipolar spectrum disorders in population-based studies

    Directory of Open Access Journals (Sweden)

    José Caetano Dell'Aglio Jr.

    2013-01-01

    Full Text Available This paper describes the findings of a systematic literature review aimed at providing an overview of the lifetime prevalence of bipolar disorder and bipolar spectrum disorders in population-based studies. Databases MEDLINE, ProQuest, Psychnet, and Web of Science were browsed for papers published in English between 1999 and May 2012 using the following search string: bipolar disorders OR bipolar spectrum disorders AND prevalence OR cross-sectional OR epidemiology AND population-based OR non-clinical OR community based. The search yielded a total of 434 papers, but only those published in peer-reviewed journals and with samples aged ≥ 18 years were included, resulting in a final sample of 18 papers. Results revealed rather heterogeneous findings concerning the prevalence of bipolar disorders and bipolar spectrum disorders. Lifetime prevalence of bipolar disorder ranged from 0.1 to 7.5%, whereas lifetime prevalence of bipolar spectrum disorders ranged from 2.4 to 15.1%. Differences in the rates of bipolar disorder and bipolar spectrum disorders may be related to the consideration of subthreshold criteria upon diagnosis. Differences in the prevalence of different subtypes of the disorder are discussed in light of diagnostic criteria and instruments applied.

  16. Abordagens psicoterápicas no transtorno bipolar Psychoterapeutic approach in bipolar disorder

    Directory of Open Access Journals (Sweden)

    Paulo Knapp

    2005-01-01

    Full Text Available Embora o tratamento farmacológico seja essencial para o tratamento do transtorno bipolar, apenas 40% de todos os pacientes que aderem às medicações permanecem assintomáticos durante o período de seguimento, o que tem levado ao desenvolvimento de intervenções psicoterápicas associadas. O objetivo deste artigo é examinar as evidências atuais da eficácia de intervenções psicoterápicas no tratamento do transtorno bipolar. Foi realizada uma pesquisa bibliográfica por meio do MedLine, PsychoINFO, Lilacs e Cochrane Data Bank, até o ano de 2004, em que foram procurados artigos originais e revisões sobre as abordagens psicoterápicas utilizadas no tratamento do transtorno bipolar. Há várias abordagens que podem se mostrar úteis no tratamento do transtorno bipolar. A psicoeducação e a terapia cognitivo-comportamental apresentam as evidências mais consistentes e são as técnicas mais amplamente estudadas. As intervenções envolvendo familiares e a terapia interpessoal e de ritmo social se mostram tratamentos eficazes em determinadas situações. Há alguns estudos empregando a terapia psicodinâmica no transtorno bipolar, mas são estudos com limitações metodológicas. Apesar de haver evidências demonstrando a eficácia de determinadas abordagens psicoterápicas no transtorno bipolar, ainda é necessária a realização de estudos posteriores que comprovem tais dados e que desenvolvam tratamentos baseados em modelos etiológicos e que identifiquem tratamentos específicos para as diferentes fases e tipos de transtorno bipolar.Although pharmacological treatment is essential for treating bipolar disorder, less than half of all medication compliant patients are non-symptomatic during follow-up, which has led to developments of adjunctive psychosocial interventions. This paper examines the current evidence for effectiveness of psychotherapeutic interventions in the treatment of bipolar disorder. Searches were undertaken through Med

  17. Clinical status of comorbid bipolar disorder and borderline personality disorder.

    Science.gov (United States)

    Parker, Gordon; Bayes, Adam; McClure, Georgia; Del Moral, Yolanda Romàn Ruiz; Stevenson, Janine

    2016-09-01

    The status and differentiation of comorbid borderline personality disorder and bipolar disorder is worthy of clarification. To determine whether comorbid borderline personality disorder and bipolar disorder are interdependent or independent conditions. We interviewed patients diagnosed with either a borderline personality disorder and/or a bipolar condition. Analyses of participants grouped by DSM diagnoses established that those with comorbid conditions scored similarly to those with a borderline personality disorder alone on all key variables (i.e. gender, severity of borderline personality scores, developmental stressors, illness correlates, self-injurious behaviour rates) and differed from those with a bipolar disorder alone on nearly all non-bipolar item variables. Similar findings were returned for groups defined by clinical diagnoses. Comorbid bipolar disorder and borderline personality disorder is consistent with the formal definition of comorbidity in that, while coterminous, individuals meeting such criteria have features of two independent conditions. © The Royal College of Psychiatrists 2016.

  18. Does bipolar pacemaker current activate blood platelets?

    DEFF Research Database (Denmark)

    Gjesdal, Grunde; Hansen, Annebirthe Bo; Brandes, Axel

    2009-01-01

    to the pacemaker can. METHODS: Platelet-rich plasma was prepared from two healthy subjects. Platelet reactivity to the agonist ADP was tested in paired samples in an aggregometer in a case/control setup. RESULTS: Eighteen of 46 tested pairs of platelet-rich plasma showed increased reactivity in the paced sample......OBJECTIVE: The aim of this study was to investigate whether bipolar pacemaker current lead can activate blood platelets. The null hypothesis was that 1 minute of electrical stimulation of platelets would not influence their subsequent reactivity to adenosine diphosphate (ADP). BACKGROUND: Both...... platelets and muscle cells contain actin and myosin filaments, and both cells are activated following calcium influx. Muscle cells open their calcium channels and contract when exposed to an electric current. Current through a bipolar pacemaker lead will expose a small volume of blood, including platelets...

  19. Bias in emerging biomarkers for bipolar disorder

    DEFF Research Database (Denmark)

    Carvalho, A F; Köhler, C A; Fernandes, B S

    2016-01-01

    BACKGROUND: To date no comprehensive evaluation has appraised the likelihood of bias or the strength of the evidence of peripheral biomarkers for bipolar disorder (BD). Here we performed an umbrella review of meta-analyses of peripheral non-genetic biomarkers for BD. METHOD: The Pubmed/Medline, E......BACKGROUND: To date no comprehensive evaluation has appraised the likelihood of bias or the strength of the evidence of peripheral biomarkers for bipolar disorder (BD). Here we performed an umbrella review of meta-analyses of peripheral non-genetic biomarkers for BD. METHOD: The Pubmed....../Medline, EMBASE and PsycInfo electronic databases were searched up to May 2015. Two independent authors conducted searches, examined references for eligibility, and extracted data. Meta-analyses in any language examining peripheral non-genetic biomarkers in participants with BD (across different mood states...

  20. Udvikling af medicinsk behandling mod bipolar lidelse

    DEFF Research Database (Denmark)

    Ellegaard, Pernille Kempel

    2015-01-01

    Selvom Esbjerg ligger i vandkants Danmark, er det den Psykiatriske Forskningsenhed i denne by, der er primus motor for et stort forsøg blandt mennesker, der lider af bipolar lidelse. Forsøget hedder ”NACOS”, og er et medicinsk forsøg til mennesker, der befinder sig i den depressive fase.......Selvom Esbjerg ligger i vandkants Danmark, er det den Psykiatriske Forskningsenhed i denne by, der er primus motor for et stort forsøg blandt mennesker, der lider af bipolar lidelse. Forsøget hedder ”NACOS”, og er et medicinsk forsøg til mennesker, der befinder sig i den depressive fase....

  1. Bipolar zinc/oxygen battery development

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, S. [Paul Scherrer Inst. (PSI), Villigen (Switzerland); Schlatter, C. [Swiss Federal Inst. of Technology, Lausanne (Switzerland)

    1997-06-01

    A bipolar electrically rechargeable Zn/O{sub 2} battery has been developed. Reticulated copper foam served as substrate for the zinc deposit on the anodic side, and La{sub 0.6}Ca{sub 0.4}CoO{sub 3}-catalyzed bifunctional oxygen electrodes were used on the cathodic side of the cells. The 100 cm{sup 2} unit cell had an open circuit voltage of 1,4 V(O{sub 2}) in moderately alkaline electrolyte. The open circuit voltage and the peak power measured for a stack containing seven cells were ca. 10V and 90W, respectively. The current-potential behaviour was determined as a function of the number of bipolar cells, and the maximum discharge capacity was determined at different discharge rates. (author) 4 figs., 1 ref.

  2. High rate lithium/thionyl chloride bipolar battery development

    Science.gov (United States)

    Russell, P. G.; Goebel, F.

    The lithium/thionyl chloride ( {Li}/{SOCl2}) electrochemistry is capable of providing high power and high specific power, especially under pulse discharge conditions, when cells containing thin components are arranged in a bipolar configuration. This paper describes recent work concerned with bipolar cell design, cathode evaluation, component manufacturing methods, and the assembly and testing of bipolar modules containing up to 150 cells for Sonobuoy application.

  3. High rate lithium-thionyl chloride bipolar battery development

    Energy Technology Data Exchange (ETDEWEB)

    Russell, P.G.; Goebel, F. [Yardney Technical Products, Inc., Pawcatuck, CT (United States)

    1994-12-31

    The lithium/thionyl chloride system is capable of providing both high power and high energy density when cells containing thin components are arranged in a bipolar configuration. Electrode current densities in excess of 300mA/cm{sup 2} are achieved during pulse discharge. The present work is concerned with bipolar cell design, cathode evaluation, component manufacturing methods, and the assembly and testing of bipolar modules containing up to 150 cells.

  4. High rate lithium/thionyl chloride bipolar battery development

    Energy Technology Data Exchange (ETDEWEB)

    Russell, P.G. [Yardney Technical Products, Inc., Pawcatuck, CT (United States); Goebel, F. [Yardney Technical Products, Inc., Pawcatuck, CT (United States)

    1995-04-01

    The lithium/thionyl chloride (Li/SOCl{sub 2}) electrochemistry is capable of providing high power and high specific power, especially under pulse discharge conditions, when cells containing thin components are arranged in a bipolar configuration. This paper describes recent work concerned with bipolar cell design, cathode evaluation, component manufacturing methods, and the assembly and testing of bipolar modules containing up to 150 cells for Sonobuoy application. (orig.)

  5. The bipolar II disorder personality traits, a true syndrome?

    Science.gov (United States)

    Gudmundsson, Einar

    2015-06-01

    The author was struck by the similarities and commonality of complaints, aside from mood swings, made by Bipolar II patients and started registrating these complaints. This registrational work eventually led to the development of The Bipolar II Syndome Checklist. The aim of this work was to understand how widely the Bipolar II disorder affects the personality, and what disturbing personality traits are the most common? Deliberately, no attempt was made to diagnose psychiatric comorbidities, in the hope that one would get a clearer view of what symptoms, if any, could be considered a natural part of the Bipolar II Disorder. As far as the author knows this is a novel approach. 105 Bipolar II patients completed the Bipolar II Syndrome Checklist. The answers to the 44 questions on the list are presented in tables. Symptoms like anxiety, low self esteem, paranoia, extreme hurtfulness, migraine, Post Partum Depression, obsessive traits, alcoholism in the family are amongst the findings which will be presented in greater detail. No control group. Bipolar I patients excluded. The Bipolar II Syndrome Checklist has not been systematically validated. The results show that Bipolar II Disorder causes multiple symptoms so commonly that it may be justified to describe it as a syndrome, The Bipolar II Syndrome. Also these disturbances commonly lie in families of Bipolar II patients and are in all likelihood, greatly underdiagnosed. The clinical relevance of this study lies in increasing our knowledge and understanding of the nature of the Bipolar II Disorder, which in all probability will increase the diagnostic and treatment accuracy, since clinicians are more likely to scan for other symptoms needing treatment. Copyright © 2015 Elsevier B.V. All rights reserved.

  6. The relationship between borderline personality disorder and bipolar disorder

    OpenAIRE

    Zimmerman, Mark; Morgan, Theresa A.

    2013-01-01

    It is clinically important to recognize both bipolar disorder and borderline personality disorder (BPD) in patients seeking treatment for depression, and it is important to distinguish between the two. Research considering whether BPD should be considered part of a bipolar spectrum reaches differing conclusions. We reviewed the most studied question on the relationship between BPD and bipolar disorder: their diagnostic concordance. Across studies, approximately 10% of patients with BPD had bi...

  7. Bipolar Disorder: What Can Psychotherapists Learn From the Cognitive Research?

    OpenAIRE

    Johnson, Sheri; Tran, Tanya

    2007-01-01

    Randomized controlled trials of psychological treatment, principally cognitive therapy, for bipolar disorder have yielded inconsistent results. Given the status of this evidentiary base, we provide a more fine-grained analysis of the cognitive profiles associated with bipolar disorder to inform clinical practice. In this practice-friendly review, we consider evidence that both negative and positive cognitive styles are related to bipolar disorder. Cross-sectional and prospective evidence sugg...

  8. Smartphone based treatment in bipolar disorder

    DEFF Research Database (Denmark)

    Faurholt-Jepsen, M; Frost, M.; Bardram, J.E.

    2016-01-01

    During this symposium, results from a randomized controlled trial investigating the effect of smartphone based electronic self-monitoring on the severity of depressive and manic symptoms will be presented and discussed.Further, we will present and discuss the use of automatically generated...... objective smartphone data on behavioral activities (eg social activities, mobility and physical activity) as electronic biomarkers of illness activity in bipolar disorder....

  9. Circadian Phase Preference in Pediatric Bipolar Disorder

    OpenAIRE

    Kerri L. Kim; Alexandra B. Weissman; Megan E. Puzia; Grace K. Cushman; Karen E. Seymour; Ezra Wegbreit; Mary A. Carskadon; Daniel P. Dickstein

    2014-01-01

    Pediatric bipolar disorder (BD) rates have notably increased over the past three decades. Given the significant morbidity and mortality associated with BD, efforts are needed to identify factors useful in earlier detection to help address this serious public health concern. Sleep is particularly important to consider given the sequelae of disrupted sleep on normative functioning and that sleep is included in diagnostic criteria for both Major Depressive and Manic Episodes. Here, we examine on...

  10. Bipolar disorder, a precursor of Parkinson's disease?

    Directory of Open Access Journals (Sweden)

    Tânia M.S. Novaretti

    Full Text Available ABSTRACT Parkinson's disease is a neurodegenerative disorder predominantly resulting from dopamine depletion in the substantia nigra pars compacta. Some psychiatric disorders may have dopaminergic dysfunction as their substrate. We describe a well-documented case of Parkinson's disease associated with Bipolar Disorder. Although there is some knowledge about the association between these diseases, little is known about its pathophysiology and correlation. We believe that among various hypotheses, many neurotransmitters are linked to this pathophysiology.

  11. Bipolarity and Ambivalence in Landscape Architecture

    OpenAIRE

    Koh, J.

    2010-01-01

    Our discipline of landscape architecture contains bipolarity, not only in terms of landscape and architecture but also because the idea of landscape is both aesthetic and scientific. Furthermore, within landscape architecture there is a gap between design (as implied by architecture) and planning (implying land-use plan and policy orientation) on one hand, and a similar gap between design (associated with artistic activity, concerned with aesthetics as well as science) and research (considere...

  12. Formation of Bipolar Lobes by Jets

    Science.gov (United States)

    Soker, Noam

    2002-04-01

    I conduct an analytical study of the interaction of jets, or a collimated fast wind (CFW), with a previously blown asymptotic giant branch (AGB) slow wind. Such jets (or CFWs) are supposedly formed when a compact companion, a main-sequence star, or a white dwarf accretes mass from the AGB star, forms an accretion disk, and blows two jets. This type of flow, which I think shapes bipolar planetary nebulae (PNs), requires three-dimensional gasdynamical simulations, which are limited in the parameter space they can cover. By imposing several simplifying assumptions, I derive simple expressions which reproduce some basic properties of lobes in bipolar PNs and which can be used to guide future numerical simulations. I quantitatively apply the results to two proto-PNs. I show that the jet interaction with the slow wind can form lobes which are narrow close to, and far away from, the central binary system, and which are wider somewhere in between. Jets that are recollimated and have constant cross section can form cylindrical lobes with constant diameter, as observed in several bipolar PNs. Close to their source, jets blown by main-sequence companions are radiative; only further out they become adiabatic, i.e., they form high-temperature, low-density bubbles that inflate the lobes.

  13. Historical Underpinnings of Bipolar Disorder Diagnostic Criteria

    Directory of Open Access Journals (Sweden)

    Brittany L. Mason

    2016-07-01

    Full Text Available Mood is the changing expression of emotion and can be described as a spectrum. The outermost ends of this spectrum highlight two states, the lowest low, melancholia, and the highest high, mania. These mood extremes have been documented repeatedly in human history, being first systematically described by Hippocrates. Nineteenth century contemporaries Falret and Baillarger described two forms of an extreme mood disorder, with the validity and accuracy of both debated. Regardless, the concept of a cycling mood disease was accepted before the end of the 19th century. Kraepelin then described “manic depressive insanity” and presented his description of a full spectrum of mood dysfunction which could be exhibited through single episodes of mania or depression or a complement of many episodes of each. It was this concept which was incorporated into the first DSM and carried out until DSM-III, in which the description of episodic mood dysfunction was used to build a diagnosis of bipolar disorder. Criticism of this approach is explored through discussion of the bipolar spectrum concept and some recent examinations of the clinical validity of these DSM diagnoses are presented. The concept of bipolar disorder in children is also explored.

  14. Group interpersonal and social rhythm therapy for bipolar depression.

    Science.gov (United States)

    Hoberg, Astrid A; Ponto, Julie; Nelson, Pamela J; Frye, Mark A

    2013-10-01

    To evaluate the feasibility of 2-week interpersonal and social rhythm therapy group (IPSRT-G) for bipolar depression. Participants with bipolar depression received two individual sessions, six IPSRT-G sessions, and a 12-week telephone call. The Inventory of Depressive Symptomatology-Clinician Rated (IDS-C), Young Mania Rating Scale (YMRS), Sheehan Disability Scale (SDS), and Clinical Global Impressions-Bipolar Version (CGI-BP) were used. IDS-C and SDS scores improved significantly at 12 weeks. YMRS and CGI-BP scores improved but did not reach statistical significance. The promising antidepressive response supports further study of IPSRT-G for bipolar depression. © 2013 Wiley Periodicals, Inc.

  15. The relationship between bipolar disorder and biological rhythms.

    Science.gov (United States)

    Gonzalez, Robert

    2014-04-01

    Rhythm disruption is a core feature of bipolar disorder and it has been hypothesized that disturbances of the circadian timing system play a fundamental role in the etiology of the disorder. We sought to investigate (1) theoretical models for biological rhythm disruptions in bipolar disorder, (2) physiological disturbances of biological rhythms in bipolar disorder, (3) clinical and therapeutic implications of biological rhythm disturbances in bipolar disorder, and (4) associations between circadian gene variations and bipolar disorder. PubMed database was searched systematically for articles that were published on or before May 5, 2013, and were written in English using the terms bipolar disorder, clock genes, endogenous clock, molecular clock, biological rhythms, circadian, suprachiasmatic nucleus, circadian rhythm, melatonin, and sleep. Seventy-four articles highlighting the objectives were included in the review. Data regarding exploring the association between bipolar disorder and circadian and chronobiological phenomena were reviewed and findings summarized. The literature reviewed suggests that circadian rhythm disturbance may be a feature of bipolar disorder. In toto, the literature suggests that circadian rhythm disturbances may be a feature of bipolar disorder. This area of research has received theoretical consideration as playing a significant role in the pathophysiology of the illness but has been understudied to this point. Further research in the field is warranted. © Copyright 2014 Physicians Postgraduate Press, Inc.

  16. Coping and personality in older patients with bipolar disorder.

    Science.gov (United States)

    Schouws, Sigfried N T M; Paans, Nadine P G; Comijs, Hannie C; Dols, Annemiek; Stek, Max L

    2015-09-15

    Little is known about coping styles and personality traits in older bipolar patients. Adult bipolar patients show a passive coping style and higher neuroticism scores compared to the general population. Our aim is to investigate personality traits and coping in older bipolar patients and the relationship between coping and personality. 75 Older patients (age > 60) with bipolar I or II disorder in a euthymic mood completed the Utrecht Coping List and the NEO Personality Inventory FFI and were compared to normative data. Older bipolar patients show more passive coping styles compared to healthy elderly. Their personality traits are predominated by openness, in contrast conscientiousness and altruism are relatively sparse. Neuroticism was related to passive coping styles, whereas conscientiousness was related to an active coping style. Older bipolar patients have more passive coping styles. Their personality is characterized by openness and relatively low conscientiousness and altruism. Our sample represents a survival cohort; this may explain the differences in personality traits between older patients in this study and in adult bipolar patients in other studies. The association between coping styles and personality traits is comparable to reports of younger adult patients with bipolar disorder. Longitudinal studies are warranted to explore if coping and personality change with ageing in bipolar patients and to determine which coping style is most effective in preventing mood episodes. Copyright © 2015 Elsevier B.V. All rights reserved.

  17. The electrolysis time on electrosynthesis of hydroxyapatite with bipolar membrane

    Science.gov (United States)

    Nur, Adrian; Jumari, Arif; Budiman, Anatta Wahyu; Puspitaningtyas, Stella Febianti; Cahyaningrum, Suci; Nazriati, Nazriati; Fajaroh, Fauziatul

    2018-02-01

    The electrochemical method with bipolar membrane has been successfully used for the synthesis of hydroxyapatite. In this work, we have developed 2 chambers electrolysis system separated by a bipolar membrane. The membrane was used to separate cations (H+ ions produced by the oxidation of water at the anode) and anions (OH- ions produced by the reduction of water at the cathode). With this system, we have designed that OH- ions still stay in the anions chamber because OH- ions was very substantial in the hydroxyapatite particles formation. The aim of this paper was to compare the electrolysis time on electrosynthesis of hydroxyapatite with and without the bipolar membrane. The electrosynthesis was performed at 500 mA/cm2 for 0.5 to 2 hours at room temperature and under ultrasonic cleaner to void agglomeration with and without the bipolar membrane. The electrosynthesis of hydroxyapatite with the bipolar membrane more effective than without the bipolar membrane. The hydroxyapatite has been appeared at 0.5 h of the electrolysis time with the bipolar membrane (at the cathode chamber) while it hasn't been seen without the bipolar membrane. The bipolar membrane prevents OH- ions migrate to the cation chamber. The formation of HA becomes more effective because OH- ions just formed HA particle.

  18. "Is it menopause or bipolar?": a qualitative study of the experience of menopause for women with bipolar disorder.

    Science.gov (United States)

    Perich, Tania; Ussher, Jane; Parton, Chloe

    2017-11-16

    Menopause can be a time of change for women and may be marked by disturbances in mood. For women living with a mental illness, such as bipolar disorder, little is known about how they experience mood changes during menopause. This study aimed to explore how women with bipolar disorder constructed mood changes during menopause and how this impacted on treatment decisions. Semi-structured interviews were undertaken with fifteen women who reported they had been diagnosed with bipolar disorder. Data was analysed using thematic analysis guided by a social constructionist framework. Themes identified included 'Constructions of mood change: menopause or bipolar disorder?',' Life events, bipolar disorder and menopause coming together'; 'Treatment choices for mood change during menopause'. The accounts suggested that women related to the experience of mood changes during menopause through the lens of their existing framework of bipolar disorder, with implications for understanding of self and treatment choices.

  19. The bipolarity of light and dark: A review on Bipolar Disorder and circadian cycles.

    Science.gov (United States)

    Abreu, T; Bragança, M

    2015-10-01

    Bipolar Disorder is characterized by episodes running the full mood spectrum, from mania to depression. Between mood episodes, residual symptoms remain, as sleep alterations, circadian cycle disturbances, emotional deregulation, cognitive impairment and increased risk for comorbidities. The present review intends to reflect about the most recent and relevant information concerning the biunivocal relation between bipolar disorder and circadian cycles. It was conducted a literature search on PubMed database using the search terms "bipolar", "circadian", "melatonin", "cortisol", "body temperature", "Clock gene", "Bmal1 gene", "Per gene", "Cry gene", "GSK3β", "chronotype", "light therapy", "dark therapy", "sleep deprivation", "lithum" and "agomelatine". Search results were manually reviewed, and pertinent studies were selected for inclusion as appropriate. Several studies support the relationship between bipolar disorder and circadian cycles, discussing alterations in melatonin, body temperature and cortisol rhythms; disruption of sleep/wake cycle; variations of clock genes; and chronotype. Some therapeutics for bipolar disorder directed to the circadian cycles disturbances are also discussed, including lithium carbonate, agomelatine, light therapy, dark therapy, sleep deprivation and interpersonal and social rhythm therapy. This review provides a summary of an extensive research for the relevant literature on this theme, not a patient-wise meta-analysis. In the future, it is essential to achieve a better understanding of the relation between bipolar disorder and the circadian system. It is required to establish new treatment protocols, combining psychotherapy, therapies targeting the circadian rhythms and the latest drugs, in order to reduce the risk of relapse and improve affective behaviour. Copyright © 2015 Elsevier B.V. All rights reserved.

  20. Toward the Definition of a Bipolar Prodrome: Dimensional Predictors of Bipolar Spectrum Disorders in At-Risk Youths.

    Science.gov (United States)

    Hafeman, Danella M; Merranko, John; Axelson, David; Goldstein, Benjamin I; Goldstein, Tina; Monk, Kelly; Hickey, Mary Beth; Sakolsky, Dara; Diler, Rasim; Iyengar, Satish; Brent, David; Kupfer, David; Birmaher, Boris

    2016-07-01

    The authors sought to assess dimensional symptomatic predictors of new-onset bipolar spectrum disorders in youths at familial risk of bipolar disorder ("at-risk" youths). Offspring 6-18 years old of parents with bipolar I or II disorder (N=359) and community comparison offspring (N=220) were recruited. At baseline, 8.4% of the offspring of bipolar parents had a bipolar spectrum disorder. Over 8 years, 14.7% of offspring for whom follow-up data were available (44/299) developed a new-onset bipolar spectrum disorder (15 with bipolar I or II disorder). Measures collected at baseline and follow-up were reduced using factor analyses, and factors (both at baseline and at the visit prior to conversion or last contact) were assessed as predictors of new-onset bipolar spectrum disorders. Relative to comparison offspring, at-risk and bipolar offspring had higher baseline levels of anxiety/depression, inattention/disinhibition, externalizing, subsyndromal manic, and affective lability symptoms. The strongest predictors of new-onset bipolar spectrum disorders were baseline anxiety/depression, baseline and proximal affective lability, and proximal subsyndromal manic symptoms (prisk of conversion. While youths without anxiety/depression, affective lability, and mania (and with a parent with older age at mood disorder onset) had a 2% predicted chance of conversion to a bipolar spectrum disorder, those with all risk factors had a 49% predicted chance of conversion. Dimensional measures of anxiety/depression, affective lability, and mania are important predictors of new-onset bipolar spectrum disorders in at-risk youths. These symptoms emerged from among numerous other candidates, underscoring the potential clinical and research utility of these findings.

  1. Bipolar disorder and age-related functional impairment Prejuízo funcional associado à idade e transtorno bipolar

    Directory of Open Access Journals (Sweden)

    Alice Aita Cacilhas

    2009-12-01

    Full Text Available OBJECTIVE: Although bipolar disorder is a major contributor to functional impairment worldwide, an independent impact of bipolar disorder and ageing on functioning has yet to be demonstrated. The objective of the present study was to evaluate the effect of bipolar disorder on age-related functional status using matched controls as a standard. METHOD: One-hundred patients with bipolar disorder and matched controls were evaluated for disability. Age-related effects controlled for confounders were cross-sectionally evaluated. RESULTS: Patients were significantly more impaired than controls. Regression showed effects for aging in both groups. The effect, size, however, was significantly stronger in patients. CONCLUSION: Bipolar disorder was an important effect modifier of the age impact on functioning. While a longitudinal design is needed to effectively demonstrate this different impact, this study further depicts bipolar disorder as a chronic and progressively impairing illness.OBJETIVO: O transtorno bipolar é responsável por importante parcela do prejuízo funcional ao redor do mundo. Um efeito independente do transtorno bipolar e da idade no funcionamento ainda não foi demonstrado. O presente estudo tem o objetivo de avaliar o efeito do transtorno bipolar no prejuízo funcional relacionado à idade, com controles pareados como padrão. MÉTODO: Cem pacientes com transtorno bipolar e controles pareados foram avaliados para incapacidade. Efeitos relacionados à idade, com controle para confundidores, foram investigados. RESULTADOS: Pacientes tiveram significativamente mais prejuízo que controles. A regressão mostrou efeito para a idade em ambos os grupos, e o efeito foi significativamente mais forte nos pacientes. CONCLUSÃO: O transtorno bipolar foi um importante modificador de efeito no impacto da idade no funcionamento. Enquanto um desenho de estudo longitudinal é necessário para efetivamente demonstrar este impacto diferencial, este

  2. Bipolar polygenic loading and bipolar spectrum features in major depressive disorder.

    Science.gov (United States)

    Wiste, Anna; Robinson, Elise B; Milaneschi, Yuri; Meier, Sandra; Ripke, Stephan; Clements, Caitlin C; Fitzmaurice, Garrett M; Rietschel, Marcella; Penninx, Brenda W; Smoller, Jordan W; Perlis, Roy H

    2014-09-01

    Family and genetic studies indicate overlapping liability for major depressive disorder and bipolar disorder. The purpose of the present study was to determine whether this shared genetic liability influences clinical presentation. A polygenic risk score for bipolar disorder, derived from a large genome-wide association meta-analysis, was generated for each subject of European-American ancestry (n = 1,274) in the Sequential Treatment Alternatives to Relieve Depression study (STAR*D) outpatient major depressive disorder cohort. A hypothesis-driven approach was used to test for association between bipolar disorder risk score and features of depression associated with bipolar disorder in the literature. Follow-up analyses were performed in two additional cohorts. A generalized linear mixed model including seven features hypothesized to be associated with bipolar spectrum illness was significantly associated with bipolar polygenic risk score [F = 2.07, degrees of freedom (df) = 7, p = 0.04]. Features included early onset, suicide attempt, recurrent depression, atypical depression, subclinical mania, subclinical psychosis, and severity. Post-hoc univariate analyses demonstrated that the major contributors to this omnibus association were onset of illness at age ≤ 18 years [odds ratio (OR) = 1.2, p = 0.003], history of suicide attempt (OR = 1.21, p = 0.03), and presence of at least one manic symptom (OR = 1.16, p = 0.02). The maximal variance in these traits explained by polygenic score ranged from 0.8% to 1.1%. However, analyses in two replication cohorts testing a five-feature model did not support this association. Bipolar genetic loading appeared to be associated with bipolar-like presentation in major depressive disorder in the primary analysis. However, the results were at most inconclusive because of lack of replication. Replication efforts were challenged by different ascertainment and assessment strategies in the different cohorts. The methodological approach

  3. Cargas y especies prevalentes de nematodos gastrointestinales en ovinos de pelo destinados al abasto

    Directory of Open Access Journals (Sweden)

    Omar Andrés López Ruvalcaba

    2013-01-01

    Full Text Available El objetivo del trabajo fue determinar la prevalencia y conteo de nematodos gastrointestinales (ngi de ovinos de pelo destinados al abasto. El estudio se llevó a cabo en un rastro en Villahermosa, Tabasco, donde se analizó el contenido gastrointestinal de 122 ovinos provenientes de diferentes municipios del estado de Tabasco (Centro, Emiliano Zapata, Centla, Huimanguillo y Teapa y Chiapas (Reforma. Se utilizó el procedimiento GLM del SAS para anal izar la influencia de la edad, sexo, estado fisiológico y mes de muestreo en los conteos de nematodos adultos totales y por especie. Las especies de nematodos encontrados fueron Haemonchus contortus, Trichostrongylus colubriformis y Cooperia curticei, además el cestodo Moniezia expansa. El 41 % (50/122 de los animales presentaron alguno de los anteriores parásitos. El mayor porcentaje de ovinos parasitados se encontró en los municipios de Huimanguillo (54 %, 22/41 y Centr o (40 %, 19/47. De los ovinos machos sacrificados (64/122, los de desecho (8/64 tuvieron el mayor número de ngi (2 190 ± 3263 y de las hembras (58/122, las vacías (40/58 presentaron la mayor cantidad de ngi (486 ± 1120. En los o vinos de 31 a 36 meses de edad, las cargas parasitarias (49 ± 143 fueron menores que en los animales de todas las de más edades. Se concluye que en la población de estudio la edad, sexo y estado fisiológico afectaron la prevalencia de nematodos adultos.

  4. DINÂMICAS TERRITORIAIS DOS PRINCPAIS NODAIS SULISTAS DO TRANSPORTE RODOVIÁRIO DE CARGA

    Directory of Open Access Journals (Sweden)

    Daniel Monteiro Huertas

    2016-08-01

    Full Text Available Em análise estruturada a partir da teoria do espaço geográfico, este artigo tem como objetivo demonstrar as peculiaridades e dinâmicas territoriais que corroboram a inserção do polígono gaúcho (Porto Alegre-Caxias do Sul-Lajeado-Santa Cruz do Sul e dos eixos paranaense (Ponta Grossa-Curitiba-Paranaguá e catarinense (Blumenau-Joinville-Itajaí-Florianópolis-Criciúma como centralidades da rede geográfica do transporte rodoviário de carga, cuja configuração territorial é composta por linhas e nodais que em seu conjunto expressam a organização e estruturação desta atividade na formação socioespacial brasileira e evidenciam um processo de seletividade espacial que privilegiou certos pontos e áreas em detrimento de outros, demarcado pela concentração e atuação de seus agentes. Conclui-se, mediante ampla investigação empírica, que os três Estados sulistas formam um denso corredor rodoviário longitudinal de cerca de 700 km entre Curitiba e Porto Alegre, seja pelo litoral (BRs 376, 101 e 290, seja pelo interior (BR-116, de grande importância para o conjunto do país, principalmente como centros consumidores relevantes e de produção industrial diversificada. Fluxos intrarregionais densos, entre capitais e destas com o interior de seus respectivos Estados; maior equilíbrio de frete-retorno; forte relação com São Paulo e presença significativa de caminhoneiros autônomos são outras características do conjunto de nodais em questão.

  5. Control de la carga de entrenamiento a través del CMJ en pruebas de velocidad y saltos para optimizar el rendimiento deportivo en atletismo

    Directory of Open Access Journals (Sweden)

    P. Jiménez-Reyes

    2011-01-01

    Full Text Available El estudio de la dosificación de la carga siempre ha suscitado controversias y no está resuelta cuál es la carga óptima de entrenamiento para alcanzar el mayor rendimiento. La mayoría de estudios analizan los efectos agudos del entrenamiento y las relaciones entre las variables del entrenamiento de manera sincrónica, sin que exista, en muchos casos, una evidencia científica sobre las cargas más adecuadas y su efecto en el rendimiento. Nuestro objetivo fue proporcionar una información relevante y útil para poder controlar y organizar el entrenamiento de manera racional en atletismo, obteniendo una información más completa y real de los efectos del proceso de entrenamiento. Participaron 24 sujetos que realizaron un seguimiento del control del entrenamiento a través del "Salto con Contramovimiento" (CMJ y la carga de entrenamiento durante 71 semanas. Destacamos la evolución del CMJ y la carga de entrenamiento en las cuatro semanas previas a la competición en la que se obtenía el mejor rendimiento durante las 71 semanas de seguimiento. En conclusión, si se realiza un exhaustivo control de la carga de entrenamiento y su relación con el rendimiento físico y deportivo, permitiría ajustar las cargas de entrenamiento adecuadamente, proporcionando una información relevante y útil para poder organizar el entrenamiento de manera racional.

  6. Fatores associados à carga de trabalho de enfermagem em Unidade de Terapia Intensiva Factores asociados a la carga de trabajo de enfermería en Unidad de Terapia Intensiva Factors associated with nursing workload in adult intensive care units

    Directory of Open Access Journals (Sweden)

    Leilane Andrade Gonçalves

    2007-12-01

    Full Text Available Os objetivos desta pesquisa foram analisar a carga de trabalho de enfermagem e os fatores associados a ela, no primeiro dia de internação dos pacientes na Unidade de Terapia Intensiva (UTI. Trata-se de um estudo retrospectivo, de corte transversal e com abordagem quantitativa, realizado em abril de 2002 e outubro de 2004. Os dados foram extraídos de um banco de dados que reuniu informações de 5 UTIs de dois hospitais privados e a amostra foi constituída por 214 pacientes adultos que permaneceram no mínimo 24 horas na UTI. A média do escore total do Nursing Activities Score (NAS foi de 69,9% e mediana de 68,0%. Verificou-se, segundo a mediana, que 109 (50,9% indivíduos tiveram alta carga de trabalho de enfermagem e 105 (49,1% baixa carga. Observou-se também que a gravidade, a idade do paciente e o tipo de tratamento não foram fatores associados à demanda de trabalho de enfermagem.Los objetivos de esta pesquisa fueron analizar la carga de trabajo de enfermería y los factores asociados a ella, en el primer día de internación de los pacientes en la Unidad de Terapia Intensiva (UTI. Se trata de un estudio retrospectivo, de corte transversal y con abordaje cuantitativa, realizado en abril de 2002 y octubre de 2004. Los datos fueron extraídos de un banco de datos que reunió informaciones de 5 UTIs de dos hospitales particulares y la muestra fue constituida por 214 pacientes adultos que permanecieron en el mínimo de 24 horas en la UTI. La media de escore total del Nursing Activities Store (NAS fue de 69,9% y mediana de 68,0%. Se verificó, según la mediana, que 109 (50,9% individuos tuvieron alta carga de trabajo de enfermería y 105 (49,1% baja carga. Se observó también que la gravedad, la edad del paciente y el tipo de tratamiento no fueron factores asociados a la demanda de trabajo de enfermería.This study was aimed both at analyzing the nursing workload on the first day of admission of patients in Intensive Care Units (ICUs and

  7. Coeficiente de transferência de carga nas fundações de silos verticais cilíndricos

    Directory of Open Access Journals (Sweden)

    Marivone Z. Fank

    2015-09-01

    Full Text Available RESUMOO dimensionamento das estruturas armazenadoras de grãos carece de uma norma brasileira que prescreva sobre seus projetos e ações; contudo, existem muitas lacunas no estado atual do conhecimento sendo imprescindíveis pesquisas adicionais sobre o tema. Com o objetivo de determinar a distribuição das cargas nas fundações dos silos foram instrumentadas, por meio de células de carga, quatro estacas localizadas sob o anel de um silo protótipo. O experimento ocorreu durante o período de agosto a dezembro de 2009 em Palotina, PR. As leituras das células foram realizadas por sistema automático de aquisição de dados durante o carregamento de grãos de milho e, a partir dos resultados, pode-se destacar um coeficiente de transferência médio de 0,30 para o anel até o carregamento de 44% do silo, a partir do qual ocorreu um incremento na taxa de transferência. As cargas máximas atuantes nas estacas instrumentadas foram de 800, 845, 520 e 600 kN, correspondentes a coeficientes de transferência de 0,48; 0,51; 0,31 e 0,36, respectivamente. Assim, o coeficiente regionalmente adotado de 0,30 para o dimensionamento das fundações do anel está subestimado fazendo-se necessária uma análise mais criteriosa nas taxas de transferência.

  8. Comportamiento de viviendas de ferrocemento bajo cargas cíclic Behavior of ferrocement housing under cyclical loads

    Directory of Open Access Journals (Sweden)

    Daniel Bedoya Ruiz

    2009-07-01

    Full Text Available La escasez de vivienda en el mundo ha llevado desde hace varios años a la búsqueda de nuevos materiales y sistemas alternativos para su construcción. El ferrocemento desde hace más de 25 décadas viene siendo estudiado y aplicado como solución de vivienda en varios países; Colombia, uno de ellos. En este trabajo se presenta parte de los resultados de una investigación acerca del comportamiento de las viviendas de ferrocemento bajo cargas cíclicas. Se probaron dos módulos de vivienda a escala real construidos con paneles prefabricados de pared delgada de ferrocemento. Sobre cada módulo de ferrocemento se realizaron ensayos de carga cíclica y se evaluó su comportamiento. Los resultados obtenidos muestran la sensibilidad de este sistema estructural ante varios ciclos de carga, con pérdidas de rigidez cercanas al 20% para los primeros ciclos y hasta un 85% al final de los mismos.The shortage of dwelling in the world has taken for several years to the search of new materials and alternative systems for its construction. For more than 25 decades, ferrocement has been studied and applied as a dwelling solution in several countries, among them Colombia.. This article refers to the results of a research about seismic behavior of ferrocement dwellings. Two modules built on real scale with prefabricated panels of ferrocement thin wall were used. On each module of ferrocement, tests of cyclical load were carried out, and its behavior was evaluated. The obtained results showed the sensitivity of this structural system under several cycles of load, with losses of rigidity near to 20% for the first cycles and up to 85% at the end of the same.

  9. La percepción subjetiva del esfuerzo para el control de la carga de entrenamiento en una temporada en un equipo de balonmano

    Directory of Open Access Journals (Sweden)

    Jorge Cuadrado-Reyes

    2012-01-01

    Full Text Available El propósito de esta investigación es estudiar la aplicabilidad de la Percepción Subjetiva del Esfuerzo (PSE desde una doble perspectiva, en primer lugar, como apoyo al seguimiento de la cuantificación de la carga administrada en los entrenamientos en deportes colectivos, y en segundo lugar, como herramienta ad hoc para el control diario del entrenamiento sobre lo planificado por el cuerpo técnico. La frecuencia cardiaca de reserva (FCR ha sido utilizada para controlar la carga interna de cada sesión. Trece jugadores pertenecientes a un equipo de balonmano de División de Honor española participaron en la investigación llevada a cabo a lo largo de una temporada. Los resultados mostraron que la PSE es un buen indicador de la carga de entrenamiento, consiguiéndose además un procedimiento válido para comparar valores de la carga planificada por el equipo técnico (PSEp con respecto a los valores reales de entrenamiento (PSEg (rxy= .792; p < .01. Se puede concluir que la PSE junto a la FCR (rxy= .839; p < .01 son buenos marcadores para el control de la carga de entrenamiento, no invasivos, y permiten monitorizar los estados de forma de los jugadores a lo largo de la temporada.

  10. Estudio Psicométrico del Índice de Carga Mental NASA-TLX con una Muestra de Trabajadores Españoles

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    Eva Díaz Ramiro

    2010-01-01

    Full Text Available El objetivo de este estudio fue evaluar las propiedades psicométricas del instrumento de evaluación de la carga mental de trabajo NASA-TLX en distintos grupos profesionales españoles. La muestra estuvo formada por 398 trabajadores que pertenecían a siete sectores profesionales diferentes. Todos los trabajadores evaluaron la carga mental percibida en sus puestos de trabajo, debida a cada una de las seis dimensiones de carga que distingue el NASA-TLX: esfuerzo, demanda mental, demanda física, demanda temporal, rendimiento y frustración. Los resultados mostraron una consistencia interna aceptable y una estructura factorial constituida por dos factores. Uno de los factores estaba formado únicamente por la dimensión "frustración", mientras que el otro factor englobaba a las cinco dimensiones restantes. Por último, se encontraron diferencias importantes en los perfiles de carga mental entre los grupos profesionales considerados, en todas las dimensiones de carga, excepto en rendimiento.

  11. Carga de trabajo en tres grupos de pacientes de UCI Española según el Nursing Activities Score

    Directory of Open Access Journals (Sweden)

    Francisco Javier Carmona-Monge

    Full Text Available Se objetivó valorizar la carga de trabajo al ingreso y al alta en tres grupos de pacientes (síndrome coronario agudo, insuficiencia respiratoria aguda y sepsis en terapia intensiva. Estudio descriptivo, prospectivo, de 27 meses, incluyéndose 563 pacientes, valorando carga de trabajo según Nursing Activities Score. Existieron diferencias significativas en la carga de trabajo al ingreso y en el alta entre los grupos de pacientes, siendo superior en ambos momentos la de pacientes con insuficiencia respiratoria aguda y sepsis frente a pacientes coronarios. Durante los siete primeros días de estancia se mantuvo esta diferencia, desapareciendo a partir del octavo día, equilibrándose la carga de trabajo para los tres grupos. Para conseguir una adecuada dotación de personal es fundamental contar con instrumentos para medir las necesidades de cuidados y conocer la carga de trabajo de los distintos grupos de enfermos que ingresan con mayor frecuencia en las unidades de terapia intensiva.

  12. Carga de trabajo en tres grupos de pacientes de UCI Española según el Nursing Activities Score

    Directory of Open Access Journals (Sweden)

    Francisco Javier Carmona-Monge

    2013-04-01

    Full Text Available Se objetivó valorizar la carga de trabajo al ingreso y al alta en tres grupos de pacientes (síndrome coronario agudo, insuficiencia respiratoria aguda y sepsis en terapia intensiva. Estudio descriptivo, prospectivo, de 27 meses, incluyéndose 563 pacientes, valorando carga de trabajo según Nursing Activities Score. Existieron diferencias significativas en la carga de trabajo al ingreso y en el alta entre los grupos de pacientes, siendo superior en ambos momentos la de pacientes con insuficiencia respiratoria aguda y sepsis frente a pacientes coronarios. Durante los siete primeros días de estancia se mantuvo esta diferencia, desapareciendo a partir del octavo día, equilibrándose la carga de trabajo para los tres grupos. Para conseguir una adecuada dotación de personal es fundamental contar con instrumentos para medir las necesidades de cuidados y conocer la carga de trabajo de los distintos grupos de enfermos que ingresan con mayor frecuencia en las unidades de terapia intensiva.

  13. Medication therapy: adherence, knowledge and difficulties of elderly people from bipolar disorder Terapéutica medicamentosa: adhesión, conocimiento y dificultades de personas ancianas portadoras de trastorno bipolar Terapêutica medicamentosa: adesão, conhecimento e dificuldades de idosos com transtorno bipolar

    Directory of Open Access Journals (Sweden)

    Ligiane Paula da Cruz

    2011-08-01

    la auto-administración de los fármacos, los efectos colaterales y las dudas sobre la necesidad de los medicamentos. Se concluye que son necesarias inversiones en acciones educativas y de promoción de la adhesión que contemplen las dificultades experimentadas por los ancianos con TAB en el seguimiento de la fármacoterapia para garantizar la seguridad en la terapéutica medicamentosa.Este estudo teve como objetivo verificar a adesão, o conhecimento e as dificuldades de idosos com transtorno afetivo bipolar (TAB, em relação à terapêutica medicamentosa, prescrita para controle do referido transtorno. Participaram do estudo 17 idosos com TAB atendidos em um núcleo de saúde mental. Foram realizadas entrevista semiestruturada e aplicação de escalas. Os dados foram analisados com abordagem quali-quantitativa. Identificou-se baixo grau de adesão ao tratamento farmacológico e déficit no conhecimento sobre os medicamentos, especialmente sobre as doses e frequência de administração. Entre as dificuldades inerentes à farmacoterapia relataram-se: a obrigatoriedade da polifarmacoterapia, o desejo de encerrar o tratamento farmacológico, limitações na autoadministração dos fármacos, efeitos colaterais e dúvidas sobre a necessidade dos medicamentos. São necessários investimentos em ações educativas e de promoção da adesão que contemplem as dificuldades vivenciadas pelos idosos com TAB, no seguimento da farmacoterapia, para garantia de segurança na terapêutica medicamentosa.

  14. Risperidone Mono - Therapy as Prophylaxis in Bipolar Affective Disorders

    OpenAIRE

    Trivedi, Mohit; Pinto, Denzil; Safeekh, A.T.

    2004-01-01

    Risperidone has been found to be useful in the treatment of acute bipolar disorders. This is a case report where risperidone mono therapy has been found to be effective in prophylaxis of bipolar affective disorder. The pharmacological and clinical implications of risperidone in the management of BPAD are discussed

  15. Neurocognitive and Neuroimaging Predictors of Clinical Outcome in Bipolar Disorder

    OpenAIRE

    Bearden, Carrie E.; Woogen, Michelle; Glahn, David C.

    2010-01-01

    Historically, bipolar disorder has been conceptualized as a disease involving episodic rather than chronic dysfunction. However, increasing evidence indicates that bipolar disorder is associated with substantial inter-episode psychosocial and vocational impairment. Here we review the contributions of neurocognitive deficits and structural and functional neuroanatomic alterations to the observed functional impairments. In particular, compelling evidence now suggests that neurocognitive impairm...

  16. Olfactocentric Paralimbic Cortex Morphology in Adolescents with Bipolar Disorder

    Science.gov (United States)

    Wang, Fei; Kalmar, Jessica H.; Womer, Fay Y.; Edmiston, Erin E.; Chepenik, Lara G.; Chen, Rachel; Spencer, Linda; Blumberg, Hilary P.

    2011-01-01

    The olfactocentric paralimbic cortex plays a critical role in the regulation of emotional and neurovegetative functions that are disrupted in core features of bipolar disorder. Adolescence is thought to be a critical period in both the maturation of the olfactocentric paralimbic cortex and in the emergence of bipolar disorder pathology. Together,…

  17. Pediatric Bipolar Disorder: Evidence for Prodromal States and Early Markers

    Science.gov (United States)

    Luby, Joan L.; Navsaria, Neha

    2010-01-01

    Background: Childhood bipolar disorder remains a controversial but increasingly diagnosed disorder that is associated with significant impairment, chronic course and treatment resistance. Therefore, the search for prodromes or early markers of risk for later childhood bipolar disorder may be of great importance for prevention and/or early…

  18. The Enigma of Bipolar Disorder in Children and Adolescents

    Science.gov (United States)

    Hatchett, Gregory T.

    2009-01-01

    In the past decade, there has been a proliferation in the number of children and adolescents diagnosed with bipolar disorder. Except in rare cases, the young people who receive this diagnosis do not meet the strict diagnostic criteria for bipolar disorder I or II in the DSM-IV-TR. Many pediatric psychiatrists insist there are important development…

  19. Bipolar Disorder in Children: Implications for Speech-Language Pathologists

    Science.gov (United States)

    Quattlebaum, Patricia D.; Grier, Betsy C.; Klubnik, Cynthia

    2012-01-01

    In the United States, bipolar disorder is an increasingly common diagnosis in children, and these children can present with severe behavior problems and emotionality. Many studies have documented the frequent coexistence of behavior disorders and speech-language disorders. Like other children with behavior disorders, children with bipolar disorder…

  20. Bipolar-FET combinational power transistors for power conversion applications

    Science.gov (United States)

    Chen, D. Y.; Chin, S. A.

    1984-01-01

    Four bipolar-FET (field-effect transistor) combinational transistor configurations are compared from the application point of view. The configurations included are FET-Darlington (cascade), emitter-open switch (cascode), parallel configuration, and FET-gated bipolar transistors (FGT).

  1. A Scalable Mextram Model for Advanced Bipolar Circuit Design

    NARCIS (Netherlands)

    Wu, H.C.

    2007-01-01

    In this thesis, a referenced based scaling approach and its parameter extraction for the bipolar transistor model Mextram is proposed. It is mainly based on the physical properties of the Mextram parameters, which scale with the junction temperature and geometry of the bipolar transistor. The

  2. New types of bipolar fuzzy sets in -semihypergroups

    Directory of Open Access Journals (Sweden)

    Naveed Yaqoob

    2016-04-01

    Full Text Available The notion of bipolar fuzzy set was initiated by Lee (2000 as a generalization of the notion fuzzy sets and intuitionistic fuzzy sets, which have drawn attention of many mathematicians and computer scientists. In this paper, we initiate a study on bipolar ( , -fuzzy sets in -semihypergroups. By using the concept of bipolar ( , -fuzzy sets (Yaqoob and Ansari, 2013, we introduce the notion of bipolar ( , -fuzzy sub -semihypergroups (-hyperideals and bi--hyperideals and discuss some basic results on bipolar ( , -fuzzy sets in -semihypergroups. Furthermore, we define the bipolar fuzzy subset ,               and prove that if  ,       is a bipolar ( , -fuzzy sub -semihypergroup (resp., -hyperideal and bi--hyperideal of H; then ,               is also a bipolar ( , -fuzzy sub -semihypergroup (resp., -hyperideal and bi--hyperideal of H.

  3. Family environment patterns in families with bipolar children.

    Science.gov (United States)

    Belardinelli, Cecilia; Hatch, John P; Olvera, Rene L; Fonseca, Manoela; Caetano, Sheila C; Nicoletti, Mark; Pliszka, Steven; Soares, Jair C

    2008-04-01

    We studied the characteristics of family functioning in bipolar children and healthy comparison children. We hypothesized that the family environment of bipolar children would show greater levels of dysfunction as measured by the Family Environment Scale (FES). We compared the family functioning of 36 families that included a child with DSM-IV bipolar disorder versus 29 comparison families that included only healthy children. All subjects and their parents were assessed with the K-SADS-PL interview. The parents completed the FES to assess their current family functioning. Multivariate analysis of variance was used to compare the family environment of families with and without offspring with bipolar disorder. Parents of bipolar children reported lower levels of family cohesion (pconflict (pfamilies where a parent had a history of mood disorders compared to families where parents had no history of mood disorders. Length of illness in the affected child was inversely associated with family cohesion (r=-0.47, p=0.004). Due to the case-control design of the study, we cannot comment on the development of these family problems or attribute their cause specifically to child bipolar disorder. Families with bipolar children show dysfunctional patterns related to interpersonal interactions and personal growth. A distressed family environment should be addressed when treating children with bipolar disorder.

  4. Tailoring the interface layer of the bipolar membrane

    NARCIS (Netherlands)

    Balster, J.H.; Srinkantharajah, S.; Sumbharaju, R.; Punt, Ineke G.M.; Lammertink, Rob G.H.; Stamatialis, Dimitrios; Wessling, Matthias

    2010-01-01

    This work investigates various parameters affecting the water splitting of bipolar ion-exchange membranes. We show that the amount of functional groups and the water content of the interface layer have a strong influence on the bipolar membrane resistance. Use of anion exchange layers containing

  5. Major Ups and Downs: Bipolar Disorder Brings Extreme Mood Swings

    Science.gov (United States)

    ... are severe—making it hard for you to sleep, stay focused or go to work—it may be a sign of bipolar disorder. Not only can bipolar disorder damage relationships, affect your grades and make it hard to keep a job; ...

  6. Risk Factors of Attempted Suicide in Bipolar Disorder

    Science.gov (United States)

    Cassidy, Frederick

    2011-01-01

    Suicide rates of bipolar patients are among the highest of any psychiatric disorder, and improved identification of risk factors for attempted and completed suicide translates into improved clinical outcome. Factors that may be predictive of suicidality in an exclusively bipolar population are examined. White race, family suicide history, and…

  7. Premorbid intelligence and educational level in bipolar and unipolar disorders

    DEFF Research Database (Denmark)

    Sørensen, Holger Jelling; Sæbye, Ditte; Urfer-Parnas, Annick

    2012-01-01

    Registry-based studies have found no or weak associations between premorbid intelligence and the broad entity of affective spectrum disorder, but none of the studies compared bipolar/unipolar subgroups.......Registry-based studies have found no or weak associations between premorbid intelligence and the broad entity of affective spectrum disorder, but none of the studies compared bipolar/unipolar subgroups....

  8. The Dutch Bipolar Offspring Study : 12-Year Follow-Up

    NARCIS (Netherlands)

    Mesman, Esther; Nolen, Willem A.; Reichart, Catrien G.; Wals, Marjolein; Hillegers, Manon N. J.

    Objective: Offspring of bipolar parents have a genetically increased risk of developing mood disorders. In a longitudinal study, the authors followed a bipolar offspring cohort from adolescence into adulthood to determine the onset, prevalence, and early course of mood disorders and other

  9. Treatment outcomes of acute bipolar depressive episode with psychosis.

    Science.gov (United States)

    Caldieraro, Marco Antonio; Dufour, Steven; Sylvia, Louisa G; Gao, Keming; Ketter, Terence A; Bobo, William V; Walsh, Samantha; Janos, Jessica; Tohen, Mauricio; Reilly-Harrington, Noreen A; McElroy, Susan L; Shelton, Richard C; Bowden, Charles L; Deckersbach, Thilo; Nierenberg, Andrew A

    2018-01-12

    The impact of psychosis on the treatment of bipolar depression is remarkably understudied. The primary aim of this study was to compare treatment outcomes of bipolar depressed individuals with and without psychosis. The secondary aim was to compare the effect of lithium and quetiapine, each with adjunctive personalized treatments (APTs), in the psychotic subgroup. We assessed participants with DSM-IV bipolar depression included in a comparative effectiveness study of lithium and quetiapine with APTs (the Bipolar CHOICE study). Severity was assessed by the Bipolar Inventory of Symptoms Scale (BISS) and by the Clinical Global Impression Scale-Severity-Bipolar Version (CGI-S-BP). Mixed models were used to assess the course of symptom change, and Cox regression survival analysis was used to assess the time to remission. Psychotic features were present in 10.6% (n = 32) of the depressed participants (n = 303). Those with psychotic features had higher scores on the BISS before (75.2 ± 17.6 vs. 54.9 ± 16.3; P Bipolar depressive episodes with psychotic features are more severe, and compared to nonpsychotic depressions, present a similar course of improvement. Given the small number of participants presenting psychosis, the lack of statistically significant difference between lithium- and quetiapine-based treatment of psychotic bipolar depressive episodes needs replication in a larger sample. © 2018 Wiley Periodicals, Inc.

  10. The CBCL Bipolar Profile and Attention, Mood, and Behavior Dysregulation

    Science.gov (United States)

    Doerfler, Leonard A.; Connor, Daniel F.; Toscano, Peter F.

    2011-01-01

    Biederman and colleagues reported that a CBCL profile identified youngsters who were diagnosed with bipolar disorder. Some studies found that this CBCL profile does not reliably identify children who present with bipolar disorder, but nonetheless this CBCL does identify youngsters with severe dysfunction. However, the nature of the impairment of…

  11. Bipolar Disorder: not only in the Brain - immunological aspects

    NARCIS (Netherlands)

    E.M. Knijff (Esther)

    2006-01-01

    textabstractThe main objective of this thesis was to obtain more insight in the role of the immune system in the pathogenesis of bipolar disorder by investigating various aberrancies in the immune system of patients with bipolar disorder. In Chapter 1 some general concepts, important for the

  12. Precursors in adolescence of adult-onset bipolar disorder.

    Science.gov (United States)

    Hiyoshi, Ayako; Sabet, Julia A; Sjöqvist, Hugo; Melinder, Carren; Brummer, Robert J; Montgomery, Scott

    2017-08-15

    Although the estimated contribution of genetic factors is high in bipolar disorder, environmental factors may also play a role. This Swedish register-based cohort study of men examined if physical and psychological characteristics in late adolescence, including factors previously linked with bipolar disorder (body mass index, asthma and allergy), are associated with subsequent bipolar disorder in adulthood. Unipolar depression and anxiety are analysed as additional outcomes to identify bipolar disorder-specific associations. A total of 213,693 men born between 1952 and 1956, who participated in compulsory military conscription assessments in late adolescence were followed up to 2009, excluding men with any psychiatric diagnoses at baseline. Cox regression estimated risk of bipolar disorder, depression and anxiety in adulthood associated with body mass index, asthma, allergy, muscular strength stress resilience and cognitive function in adolescence. BMI, asthma and allergy were not associated with bipolar disorder. Higher grip strength, cognitive function and stress resilience were associated with a reduced risk of bipolar disorder and the other disease outcomes. The sample consisted only of men; even though the characteristics in adolescence pre-dated disease onset, they may have been the consequence of prodromal disease. Associations with body mass index and asthma found by previous studies may be consequences of bipolar disorder or its treatment rather than risk factors. Inverse associations with all the outcome diagnoses for stress resilience, muscular strength and cognitive function may reflect general risks for these psychiatric disorders or intermediary factors. Copyright © 2017 Elsevier B.V. All rights reserved.

  13. Psychodynamics of hypersexuality in children and adolescents with bipolar disorder.

    Science.gov (United States)

    Adelson, Stewart

    2010-01-01

    It has recently become evident that bipolar disorder exists in children and adolescents. The criteria for making the diagnosis of juvenile bipolar disorder (JBD) are in the process of being proposed for the fifth edition of the Diagnostic and Statistical Manual (DSM-V). In adults, a criterion for bipolar disorder is excessive involvement in pleasurable activities including hypersexuality. Recently, some clinicians and researchers have suggested that hypersexuality be included as a criterion for JBD as well. Although abnormal sexuality has been reported to be present in some youth thought to have JBD, the reason for this association is not yet clear. Hypersexuality may be primary and intrinsic to bipolar disorder in youth, secondary and associated with it as the result of psychosocial influences or psychodynamic factors, or due to general aggression and disruptive behavior. Not only have developmental psychosocial factors that may influence sexuality in children and adolescence not been fully investigated, but psychodynamic influences have been omitted from modern etiological constructs as well. This report discusses the importance of psychosocial and psychodynamic influences on the sexual experience and activity of bipolar children. It is proposed that a developmental, psychodynamically informed model is helpful in understanding sexuality in children and adolescents with bipolar disorder. It is also suggested that assessment of psychosocial and psychodynamic influences on the sexuality of bipolar children is necessary in order to adequately assess whether hypersexuality should be a criterion of bipolar disorder in youth.

  14. Métodos de cuantificación de las cargas de entrenamiento y competición

    OpenAIRE

    Mujika, Iñigo

    2006-01-01

    La cuantificación del entrenamiento es fundamental para evaluar las respuestas del deportista a las cargas de trabajo y determinar la relación entre el entrenamiento y el rendimiento. El entrenamiento se compone de tres variables fundamentales: volumen, intensidad y frecuencia. El volumen y la frecuencia son relativamente fáciles de cuantificar, mientras que la cuantificación de la intensidad resulta más problemática. Entre los métodos de cuantificación utilizados destacan los cuestionarios r...

  15. Um sistema de automação para gerenciadoras de risco de transportes rodoviários de cargas

    OpenAIRE

    Andrade, André Meireles de

    2015-01-01

    O alto índice de roubos de cargas e veículos e de acidentes nas rodovias brasileiras tem tornado a negociação de seguros cada vez menos vantajosa para as seguradoras, chegando muitas vezes a inviabilizar esse tipo de negócio, comum a diversos tipos de bens. Como solução, as empresas de gerenciamento de risco surgiram no mercado no intuito de reduzir os custos das seguradoras através da prevenção de roubos e acidentes. No entanto, essas empresas que trabalham com operações co...

  16. Determinación del comportamiento bajo cargas concentradas de perfiles de lámina delgada ( MM

    Directory of Open Access Journals (Sweden)

    Maritzabel Molina Herrera

    2006-09-01

    Full Text Available En el campo de la lámina delgada continuamente aparecen nuevos tipos de perfiles que son desarrollados con el objeto de mejorar los ya existentes. Un ejemplo de esto es la aparición del perfil M, elaborado para melorar la eficiencia a corte del perfil C y su resistencia al arrugamiento del alma por efecto de cargas concentradas. Teóricamente, se logra el objetivo de mejorar la resistencia a corte del perfil C y de algún modo su resistencia al arrugamiento del alma, pero debido a los dobleces generados en el alma (rigidizadores intermedios para acortar la longitud de pandeo, se producen comportamientos que desde el punto de vista de esfuerzos por flexión y deflexiones no pueden ser analizados con los fundamentos teóricos de la mecánica tradicional. Este comporta- miento se ve acentuado con la presencia de cargas concentradas. Por la razón expuesta anteriormente, a parte de la determinación de la resistencia teórica del perfil M (basada en el AISI 1996, se desarrollan pruebas sobre cuatro modelos de los que se obtienen tópicos como: carga máxima resistida, identificación visual del posible tipo de falla, deflexiones (centro de la luz y deformaciones unitarias (x, y, xy, y adicionalmente se elaboran modelos matemáticos simplificados y por elementos finitos (en el programa COSMOS/M, con el fin de hacer una revisión detallada del comportamiento de los esfuerzos y deformaciones en el perfil. La calibración de estos modelos se lleva a cabo con base en los resultados obtenidos de los ensayos. De otra parte, se hacen pruebas cíclicas balo cargas pseudoestáticas, con el objeto de estudiar el comportamiento histerético del perfil MM, con y sin rigidizadores.

  17. La carga precoz de los implantes GMI con conexión interna y superficie arenada y grabada

    OpenAIRE

    E. Velasco Ortega; L. Monsalve Guil; N. Matos Garrido; A. Jiménez Guerra; A. García Méndez; R. Medel Soteras; I. Ortiz García; A. España López

    2014-01-01

    Introducción: La implantología oral representa en la actualidad, una modalidad terapéutica odontológica en los pacientes con pérdida dental total y parcial. El estudio muestra la evaluación de los pacientes tratados mediante carga precoz de implantes de titanio con conexión interna y superficie arenada y grabada. Métodos: 39 pacientes con pérdidas dentales fueron tratados con implantes con conexión interna y superficie arenada y grabada Frontier GMI®. Los implantes fueron cargados funcionalme...

  18. La carga cognitiva del lenguaje: Convergencia entre filosofía del lenguaje y neuroeducación

    OpenAIRE

    Durán Martínez, David

    2017-01-01

    La carga cognitiva del lenguaje hace converger Filosofía del lenguaje y neuroeducación, abriendo la posibilidad a una nueva vía de investigación para desarrollar una didáctica de las áreas filosóficas, en la enseñanza secundaria, donde lectura y escritura adquieren una dimensión nuclear dentro de un contexto de aprendizaje activo. Así, se propone una metodología plural, un pluri-método, en el sentido de una caja de herramientas pedagógicas donde existan diversos útiles para abordar de manera ...

  19. Carga de trabalho de enfermagem em unidade de terapia intensiva de cardiologia e fatores clínicos associados

    OpenAIRE

    Coelho,Filipe Utuari de Andrade; Queijo,Alda Ferreira; Andolhe,Rafaela; Gonçalves,Leilane Andrade; Padilha,Katia Grillo

    2011-01-01

    O estudo objetivou identificar a carga de trabalho de enfermagem em unidade de Terapia Intensiva de Cardiologia e verificar a associação dessa variável com características demográficas e clínicas dos pacientes. A amostra foi de 100 pacientes internados no período de agosto a setembro de 2006, na Unidade de Terapia Intensiva Cardiológica de um hospital privado, do Município de São Paulo. O Nursing Activities Score, o Symplified Acute Physiologic ScoreII e o Logistic Organ Disfunction System fo...

  20. Entrevista Percepción de Carga del Cuidado de Zarit: pruebas psicométricas para Colombia

    OpenAIRE

    Ruth Vivian Barreto-Osorio; María Stella Campos de Aldana; Gloria Mabel Carrillo-González; Rosa Coral-Ibarra; Lorena Chaparro-Díaz; Myriam Durán-Parra; Rosario Rosales-Jiménez; Vilma Tamara Ortiz-Nievas

    2015-01-01

    Objetivo: determinar la validez y confiabilidad de la Entrevista de Percepción de Carga del Cuidado de Zarit, versión de 22 ítems en español, con cuidadores familiares de personas con enfermedades crónicas en Colombia. Materiales y métodos: estudio metodoló- gico de corte transversal, con 652 cuidadores familiares de personas con enfermedades crónicas, residentes en las cinco regiones de Colombia, con el fin de establecer la validez de constructo, con un análisis factorial y la confiabilida...

  1. Efectividad de un programa en la carga de cuidado para cuidadores familiares en tres grupos culturalmente diversos

    Directory of Open Access Journals (Sweden)

    Yenny Marcela Barreto Zorza

    2017-04-01

    Full Text Available Introducción: El envejecimiento poblacional dado por la transición demográfica y epidemiológica, repercute en la dependencia de las actividades de la vida diaria de los adultos mayores, requiriendo de manera constante los cuidados de personas denominadas “cuidadores”, en quienes se genera una carga que afecta su salud física y mental. Objetivo: Evaluar la efectividad de un programa en la carga de cuidado para cuidadores familiares en tres grupos culturalmente diversos. Metodología: Investigación cuantitativa, de tipo analítico, a partir de los resultados de tres estudios cuasiexperimentales de grupos de cuidadores familiares de personas ancianas dependientes funcionalmente. Participaron 88 cuidadores de tres municipios: Bogotá, Cáqueza y Guapi, en un Programa educativo con acciones de cuidado adaptadas culturalmente. La información se recolectó con la Escala de carga de Zarit, antes y después de la implementación del programa, se realizó un análisis con prueba de rango signado de Wilcoxon en cada uno de los tres grupos. Se consideró aspectos éticos. Resultados: El programa educativo para cuidadoras familiares tuvo un efecto estadísticamente significativo en la carga de cuidado de los cuidadores de Cáqueza (valor p 0.014, posiblemente porque el programa responde a una de las necesidades prioritarias de estos cuidadores que es el cuidado de sí mismos, contrario al encontrado en Bogotá y Guapi. Lo que sugiere continuar estudios con programas a cuidadores con perspectiva cultural. Conclusión: El logro de resultados estadísticamente significativos en las cuidadoras de Cáqueza sugiere que ellas cuentan con una mejor red de apoyo familiar y vecinal, por eso asumen la asistencia al programa con mayor dedicación, integralidad y disposición de tiempo.

  2. Mecanismos neuroendocrinos de respuesta durante el estrés y la carga alostática

    OpenAIRE

    de Nicola, Alejandro Federico

    2015-01-01

    l término estrés se relaciona con la respuesta de nuestro organismo a los factores externos, internos o psicológicos que modifican el equilibrio homeostático en el cual nos desenvolvemos. Posteriormente, la noción de estrés ha sido ampliada introduciendo el concepto de alostasis o sea como nos estabilizamos frente a los cambios. Mientras el manejo ineficiente de los estresores convierte a la alostasis en una carga y conduce al desarrollo de neuropatologías, el escape de los estresores permite...

  3. [Artistic creativity and bipolar mood disorder].

    Science.gov (United States)

    Janka, Zoltán

    2004-08-15

    Several studies and theories propose a connection between psychopathology and artistic creativity i.e. madness and genius characters share common roots. Employing scientific research data, the objective of this review is to elucidate the frequency of psychopathological alterations among writers and artists and to analyse the possible influence of bipolar mood disorder spectrum on the artistic creativity. Reviewing studies a) on retrospective investigations, based on biographies of famous persons with high creative achievements, b) on psychiatric examinations of living writers and artists, c) on individual examples of geniuses in the light of their mental status and work output correlations, and d) on creative traits and skills of diagnosed psychiatric patient populations. Beyond the practical experiences and impressions being held for ages from ancient times, the scientific observations and surveys indicate that psychopathological symptoms, especially those belonging to the bipolar mood disorder (bipolar I and II), major depression and cyclothymia categories occur more frequently among writers, poets, visual artists and composers, compared to the rates in the general population. Self-reports of writers and artists describe symptoms in their intensively creative periods which are reminiscent and characteristic of hypomanic states. Further, cognitive styles of hypomania (e.g. overinclusive thinking, richness of associations) and originality-prone creativity share many common as indicated by several authors. Among the eminent artists showing most probably manic-depressive or cyclothymic symptoms were: E. Dickinson, E. Hemingway, N. Gogol, A. Strindberg, V. Woolf, Lord Byron (G. Gordon), J. W. Goethe, V. van Gogh, F. Goya, G. Donizetti, G. F. Händel, O. Klemperer, G. Mahler, R. Schumann, and H. Wolf. Based on biographies and other studies, brief descriptions are given in the present article on the personality character of Gogol; Strindberg, Van Gogh, H

  4. Lithium in drinking water and the incidence of bipolar disorder

    DEFF Research Database (Denmark)

    Kessing, Lars V; Gerds, Thomas A; Knudsen, Nikoline N

    2017-01-01

    of bipolar disorder (primary prophylaxis). In a nation-wide population-based study, we investigated whether long-term exposure to micro levels of lithium in drinking water correlates with the incidence of bipolar disorder in the general population, hypothesizing an inverse association in which higher long......-term lithium exposure is associated with lower incidences of bipolar disorder. METHODS: We included longitudinal individual geographical data on municipality of residence, data from drinking water lithium measurements and time-specific data from all cases with a hospital contact with a diagnosis of mania/bipolar...... disorder from 1995 to 2013 (N=14 820) and 10 age- and gender-matched controls from the Danish population (N= 140 311). Average drinking water lithium exposure was estimated for all study individuals. RESULTS: The median of the average lithium exposure did not differ between cases with a diagnosis of mania/bipolar...

  5. Combinations of genetic variants associated with bipolar disorder

    DEFF Research Database (Denmark)

    Mellerup, Erling; Andreassen, Ole A.; Bennike, Bente

    2017-01-01

    The main objective of the study was to find genetic variants that in combination are significantly associated with bipolar disorder. In previous studies of bipolar disorder, combinations of three and four single nucleotide polymorphisms (SNP) genotypes taken from 803 SNPs were analyzed, and five...... clusters of combinations were found to be significantly associated with bipolar disorder. In the present study, combinations of ten SNP genotypes taken from the same 803 SNPs were analyzed, and one cluster of combinations was found to be significantly associated with bipolar disorder. Combinations from......, heterozygote or variant homozygote. In the combinations containing 10 SNP genotypes almost all the genotypes were the normal homozygote. Such a finding may indicate that accumulation in the genome of combinations containing few SNP genotypes may be a risk factor for bipolar disorder when those combinations...

  6. Diagnostic Precursors to Bipolar Disorder among Offspring of Parents with Bipolar Disorder: A Longitudinal Study

    Science.gov (United States)

    Axelson, David; Goldstein, Benjamin; Goldstein, Tina; Monk, Kelly; Yu, Haifeng; Hickey, Mary Beth; Sakolsky, Dara; Diler, Rasim; Hafeman, Danella; Merranko, John; Iyengar, Satish; Brent, David; Kupfer, David; Birmaher, Boris

    2015-01-01

    Objective Identify diagnostic risk factors of mania/hypomania in the offspring of parents with bipolar disorder (“high-risk offspring”). Method High-risk offspring aged 6-18 years (n=391) and demographically-matched offspring (n=248) of community parents without bipolar disorder were assessed longitudinally with standardized diagnostic instruments by staff blind to parental diagnoses. Follow-up assessments were completed in 91% of the offspring (mean interval 2.5 years; mean duration 6.8 years). Results High-risk offspring, as compared to community offspring, had significantly higher rates of subthreshold (hypo)manic (13.3% vs. 1.2%, pattention-deficit hyperactivity (30.7% vs. 18.2%, p=.01), disruptive behavior (27.4% vs. 15.3%, p=.03), anxiety (39.9% vs. 21.8%, p=.0002), and substance use disorders (20.0% vs. 10.1%, p=.008), but not unipolar major depressive disorder (major depression with no bipolarity; 18.9% vs. 13.7%; p=.10). Multivariate Cox regressions in the high-risk offspring showed that subthreshold (hypo)manic episodes (Hazard Ratio 2.29, p=.03), major depressive episodes (Hazard Ratio 1.99, p=.05), and disruptive behavior disorders (Hazard Ratio 2.12, p=.03) were associated with subsequent mania/hypomania. Only subthreshold (hypo)manic episodes (Hazard Ratio 7.57, passociated when analyses were restricted to prospective data. Conclusions Subthreshold (hypo)manic episodes were a diagnostic risk factor for the development of mania/hypomania in the offspring of parents with bipolar disorder, and should be a target for clinical assessment and future treatment research. Major depressive episodes and disruptive behavior disorders are also indications for close clinical monitoring of emergent bipolarity in high-risk offspring. PMID:25734353

  7. Escala de bem-estar afetivo no trabalho (Jaws: evidências de validade fatorial e consistência interna Job-related affective well-being scale (Jaws: evidences of factor validity and reliability

    Directory of Open Access Journals (Sweden)

    Valdiney Veloso Gouveia

    2008-01-01

    Full Text Available O objetivo deste estudo foi adaptar uma medida de bem-estar afetivo no trabalho para o contexto brasileiro. Especificamente, pretendeu-se conhecer evidências de validade fatorial e consistência interna da Job-Related Affective Well-Being Scale (JAWS, avaliando se as pontuações nos seus fatores diferem em função do gênero e da idade dos participantes. Participaram 298 trabalhadores de centros comerciais de pequeno e médio porte da cidade de João Pessoa (PB. A maioria destes era do sexo feminino (76,8%, com idade média de 26 anos (DP = 6,87. Através de uma análise dos componentes principais (rotação promax foram identificados dois fatores que explicaram conjuntamente 48,1% da variância total: afetos positivos (α = 0,94; 14 itens e afetos negativos (α = 0,87; 13 itens; um fator geral de bem-estar afetivo no trabalho foi também computado (α = 0,95; 27 itens. As pontuações dos participantes nestes fatores não foram influenciadas pelas variáveis gênero e idade. Estes resultados são discutidos à luz do que tem sido escrito sobre os parâmetros desta escala e da relação dos afetos com estas variáveis demográficas.This study aimed at adapting a measure of job-related affective well-being for the Brazilian milieu. Specifically, it was proposed to know evidences of factor validity and reliability of the Job-Related Affective Well-Being Scale (JAWS, assessing if its scores are influenced by participants' gender and age. The participants were 298 individuals employed in small or middle shopping malls in the city of João Pessoa, PB; most of them were female (76.8%, with a mean age of 26 years old (SD = 6.87. A main component analysis (with promax rotation was performed, revealing two components that jointly accounted for 48.1% of the total variance. They were named as positive affect (α = .94; 14 items and negative affect (α = .87; 13 items. A general factor of affective well-being was also identified (α = .95; 27 items

  8. Bipolar disorders and Wilson’s disease

    Directory of Open Access Journals (Sweden)

    Carta Mauro

    2012-05-01

    Full Text Available Abstract Background The aim of this study was to determine the risk for Bipolar Disorder (BD in Wilson’s disease (WD and to measure the impaired Quality of Life (QL in BD with WD using standardized psychiatric diagnostic tools and a case control design. Methods This was a case control study. The cases were 23 consecutive patients with WD treated at the University Hospital in Cagliari, Italy, and the controls were 92 sex- and age-matched subjects with no diagnosis of WD who were randomly selected from a database used previously for an epidemiological study. Psychiatric diagnoses according to DSM-IV criteria were determined by physicians using structured interview tools (ANTAS-SCID. QL was measured by means of SF-12. Results Compared to controls, WD patients had lower scores on the SF-12 and higher lifetime prevalence of DSM-IV major depressive disorders (OR = 5.7, 95% CI 2.4–17.3 and bipolar disorders (OR = 12.9, 95% CI 3.6–46.3. BD was associated with lower SF-12 in WD patients. Conclusions This study was the first to show an association between BD and WD using standardized diagnostic tools and a case control design. Reports in the literature about increased schizophrenia-like psychosis in WD and a lack of association with bipolar disorders may thus have been based on a more inclusive diagnosis of schizophrenia in the past. Our findings may explain the frequent reports of loss of emotional control, hyperactivity, loss of sexual inhibition, and irritability in WD patients. This study was limited by a small sample size.

  9. Detecting Bipolar Depression From Geographic Location Data.

    Science.gov (United States)

    Palmius, N; Tsanas, A; Saunders, K E A; Bilderbeck, A C; Geddes, J R; Goodwin, G M; De Vos, M

    2017-08-01

    This paper aims to identify periods of depression using geolocation movements recorded from mobile phones in a prospective community study of individuals with bipolar disorder (BD). Anonymized geographic location recordings from 22 BD participants and 14 healthy controls (HC) were collected over 3 months. Participants reported their depressive symptomatology using a weekly questionnaire (QIDS-SR 16 ). Recorded location data were preprocessed by detecting and removing imprecise data points and features were extracted to assess the level and regularity of geographic movements of the participant. A subset of features were selected using a wrapper feature selection method and presented to 1) a linear regression model and a quadratic generalized linear model with a logistic link function for questionnaire score estimation; and 2) a quadratic discriminant analysis classifier for depression detection in BD participants based on their questionnaire responses. R esults: HC participants did not report depressive symptoms and their features showed similar distributions to nondepressed BD participants. Questionnaire score estimation using geolocation-derived features from BD participants demonstrated an optimal mean absolute error rate of 3.73, while depression detection demonstrated an optimal (median ± IQR) [Formula: see text] score of 0.857 ± 0.022 using five features (classification accuracy: 0.849 ± 0.016; sensitivity: 0.839 ± 0.014; specificity: 0.872 ± 0.047). These results demonstrate a strong link between geographic movements and depression in bipolar disorder. S ignificance: To our knowledge, this is the first community study of passively recorded objective markers of depression in bipolar disorder of this scale. The techniques could help individuals monitor their depression and enable healthcare providers to detect those in need of care or treatment.

  10. Is bipolar disorder specifically associated with aggression?

    Science.gov (United States)

    Ballester, Javier; Goldstein, Tina; Goldstein, Benjamin; Obreja, Mihaela; Axelson, David; Monk, Kelly; Hickey, MaryBeth; Iyengar, Satish; Farchione, Tiffany; Kupfer, David J; Brent, David; Birmaher, Boris

    2012-01-01

    Objective Several studies have suggested that bipolar disorder (BP) in adults is associated with aggressive behaviors. However, most studies have only included inpatients and have not taken possible confounding factors into consideration. The goal of this study was to compare the prevalence of aggression in subjects with BP compared to subjects with other non-BP psychopathology and healthy controls. Methods Subjects with bipolar I disorder (BP-I) and bipolar II disorder (BP-II) (n = 255), non-BP psychopathology (n = 85), and healthy controls (n = 84) were recruited. Aggression was measured using the Aggression Questionnaire (AQ). Group comparisons were adjusted for demographic and clinical differences (e.g., comorbid disorders) and multiple comparisons. The effects of the subtype of BP, current versus past episode, polarity of current episode, psychosis, the presence of irritable mania/hypomania only, and pharmacological treatment were examined. Results Subjects with BP showed significantly higher total and subscale AQ scores (raw and T-scores) when compared with subjects with non-BP psychopathology and healthy controls. Exclusion of subjects with current mood episodes and those with common comorbid disorders yielded similar results. There were no effects of BP subtype, polarity of the current episode, irritable manic/hypomanic episodes only, or current use of pharmacological treatments. Independent of the severity of BP and polarity of the episode, those in a current mood episode showed significantly higher AQ scores than those not in a current mood episode. Subjects with current psychosis showed significantly higher total AQ score, hostility, and anger than those without current psychosis. Conclusions Subjects with BP display greater rates of anger and aggressive behaviors, especially during acute and psychotic episodes. Early identification and management of these behaviors is warranted. PMID:22548901

  11. ESTIMATIVA DAS CARGAS DE EFLUENTES INDUSTRIAIS NA BACIA HIDROGRÁFICA TAQUARI-ANTAS

    Directory of Open Access Journals (Sweden)

    Sandra Tatiana Reyes Gomez

    2017-04-01

    Full Text Available Os recursos hídricos representam, para a sociedade e o ambiente, um papel de suma importância. Em termos de sociedade relacionamos os múltiplos usos que se fazem destes, sem esquecer que o principal uso é para o consumo e abastecimento das necessidades primárias. Já, em termos de meio ambiente, sabemos que são os pilares para o suporte e desenvolvimento da biodiversidade e produção de biomassa na terra. A destinação dos resíduos industriais é uma preocupação na atualidade, e mesmo as indústrias sendo obrigadas a tratar seus resíduos antes de despejá-los nos corpos hídricos, não o estão executando com eficiência. Uma das razões que levam a esta situação é a falta de conhecimento dos efeitos que seus resíduos podem ocasionar, deixando-os em um segundo plano, outra razão é o orçamento elevado que se requer para investir em uma estação de tratamento de efluentes, considerando não somente a construção, mas também a demanda que exige a sua manutenção. A ideia parte do pressuposto de que é difícil acessar as informações referentes aos efluentes industriais gerados, sendo muitas vezes desconhecida a atividade industrial presente. Indo ao encontro da busca de soluções para esta problemática se realizou uma estimativa da carga de potencial poluidor dos efluentes industriais, tendo como área de estudo a bacia hidrográfica Taquari-Antas. Um total de 393 indústrias foram classificadas em 24 setores. O potencial poluidor de Metais da Água (MA, Tóxicos da Água (TA, Demanda Bioquímica de Oxigênio (DBO e Sólidos em Suspensão Totais (SST para o meio aquático foi estimado através da metodologia The Industrial Pollution Projection System (IPPS.

  12. Cargas elevadas de treinamento alteram funções cognitivas em jogadores de futebol

    Directory of Open Access Journals (Sweden)

    Felipe de Oliveira Matos

    2014-10-01

    Full Text Available INTRODUÇÃO: No esporte de rendimento, altas cargas de treinamento são necessárias para que ocorram adaptações biológicas que levem ao aprimoramento da forma física e do desempenho esportivo. OBJETIVO: Investigar o comportamento de variáveis psicológicas e fisiológicas, possíveis indicadores dos estados de estresse e recuperação, em jogadores de futebol ao longo da temporada esportiva, e a possibilidade da utilização desses como marcadores dos estados de treinabilidade dos atletas para prevenir quedas do desempenho e o overtraining. MÉTODOS: Participaram deste estudo 14 jogadores de futebol (18,4 ± 0,6 anos, 9,64 ± 1,61 % com gordura e VO2máx 49,46 ± 2,88 ml/kg/min da categoria júnior de uma equipe de primeira divisão do Brasil. Foram monitorados a percepção de estresse e a recuperação por meio do questionário RESTQ-Sport, a variabilidade de frequência cardíaca (VFC de repouso, analisada no domínio do tempo e da frequência, e o tempo de reação simples. Efetuaram-se três coletas de dados, um controle (C, outra após quatro semanas de treinamentos intensos (T1, e finalmente depois de quatro semanas de treinamentos leves (T2 realizados após T1. RESULTADOS: Não foi encontrada diferença significativa em nenhuma das escalas do RESTQ-Sport e na VFC nos três momentos de coletas. O tempo de reação simples apresentou um aumento significativo(p = 0,047 em T1 em relação a C. CONCLUSÃO: Os resultados indicam que o tempo de reação foi a única variável sensível às alterações do treinamento estudado, podendo ser considerado um bom indicador da treinabilidade dos atletas.

  13. Cognitive Impairment in Euthymic Pediatric Bipolar Disorder

    DEFF Research Database (Denmark)

    Elias, Liana R.; Miskowiak, Kamilla W.; Vale, Antônio M. O.

    2017-01-01

    OBJECTIVE: To perform a systematic review and meta-analysis of studies investigating neurocognition in euthymic youths with bipolar disorder (BD) compared to healthy controls (HCs). METHOD: A systematic literature search was conducted in the PubMed/MEDLINE, PsycINFO, and EMBASE databases from...... learning and memory. We also found evidence for other potential sources of heterogeneity in several ES estimates including co-occurring attention-deficit/hyperactivity disorder (ADHD) and anxiety disorders, and the use of medications. In addition, the use of different neuropsychological tests appeared...

  14. Cognitive enhancement treatments for bipolar disorder

    DEFF Research Database (Denmark)

    Miskowiak, Kamilla W; Carvalho, André F; Vieta, Eduard

    2016-01-01

    Cognitive dysfunction is an emerging treatment target in bipolar disorder (BD). Several trials have assessed the efficacy of novel pharmacological and psychological treatments on cognition in BD but the findings are contradictory and unclear. A systematic search following the PRISMA guidelines...... was conducted on PubMed and PsychInfo. Eligible articles reported randomized, controlled or open-label trials investigating pharmacological or psychological treatments targeting cognitive dysfunction in BD. The quality of the identified randomized controlled trials (RCTs) was evaluated with the Cochrane...

  15. Analysis of bipolar and CMOS amplifiers

    CERN Document Server

    Sodagar, Amir M

    2007-01-01

    The classical approach to analog circuit analysis is a daunting prospect to many students, requiring tedious enumeration of contributing factors and lengthy calculations. Most textbooks apply this cumbersome approach to small-signal amplifiers, which becomes even more difficult as the number of components increases. Analysis of Bipolar and CMOS Amplifiers offers students an alternative that enables quick and intuitive analysis and design: the analysis-by-inspection method.This practical and student-friendly text demonstrates how to achieve approximate results that fall within an acceptable ran

  16. Total Dose Effects in Conventional Bipolar Transistors

    Science.gov (United States)

    Johnston, A. H.; Swift, G. W.; Rax, B. G.

    1994-01-01

    This paper examines various factors in bipolar device construction and design, and discusses their impact on radiation hardness. The intent of the paper is to improve understanding of the underlying mechanisms for practical devices without special test structures, and to provide (1) guidance in ways to select transistor designs that are more resistant to radiation damage, and (2) methods to estimate the maximum amount of damage that might be expected from a basic transistor design. The latter factor is extremely important in assessing the risk that future lots of devices will be substantially below design limits, which are usually based on test data for older devices.

  17. Unexplored areas of psychotherapy in bipolar disorder.

    Science.gov (United States)

    Popovic, Dina; Yildiz, Ayşegül; Murphy, Paula; Colom, Francesc

    2014-01-01

    Several psychological interventions-including group psychoeducation, family-focused psychoeducation, and interpersonal social-rhythm therapy-have demonstrated prophylactic efficacy as an adjunct to medication in bipolar disorders (BDs). The field of psychological interventions for BD has experienced impressive progress over the last 15 years. Certain unexplored areas, however, require further research in order to establish the full potential of psychological interventions for BD. Such research should focus, among other things, on cognitive impairment associated with BD, BD in the elderly, comorbid anxiety disorders and other comorbidities, the treatment of BD in pregnant women, and the improvement of patients' overall physical health.

  18. Dose Rate Effects in Linear Bipolar Transistors

    Science.gov (United States)

    Johnston, Allan; Swimm, Randall; Harris, R. D.; Thorbourn, Dennis

    2011-01-01

    Dose rate effects are examined in linear bipolar transistors at high and low dose rates. At high dose rates, approximately 50% of the damage anneals at room temperature, even though these devices exhibit enhanced damage at low dose rate. The unexpected recovery of a significant fraction of the damage after tests at high dose rate requires changes in existing test standards. Tests at low temperature with a one-second radiation pulse width show that damage continues to increase for more than 3000 seconds afterward, consistent with predictions of the CTRW model for oxides with a thickness of 700 nm.

  19. Obesity in bipolar disorder: an overview.

    Science.gov (United States)

    McElroy, Susan L; Keck, Paul E

    2012-12-01

    Bipolar disorder (BD) is associated with obesity, overweight, and abdominal obesity, and BD individuals with obesity have a greater illness burden. Factors related to BD, its treatment, and the individual may all contribute to BD's association with obesity. Management strategies for the obese BD patient include use of medications with better metabolic profiles, lifestyle interventions, and adjunctive pharmacotherapy for weight loss. Obesity-related psychiatric and medical comorbidities should also be assessed and managed. Bariatric surgery may be an option for carefully selected patients. Greater research into the theoretical underpinnings and clinical management of the BD-obesity connection is needed.

  20. Early Maladaptive Schemas among patients diagnosed with bipolar disorder.

    Science.gov (United States)

    Hawke, Lisa D; Provencher, Martin D

    2012-02-01

    Bipolar disorder is associated with a variety of cognitive features that seem to play a role in affective symptoms. Schema theory may serve as a unifying theory that would explain many of these features. This study is an exploratory investigation of schema theory's Early Maladaptive Schemas (EMSs) among individuals diagnosed with bipolar disorder. A sample of 74 participants with bipolar disorder and 99 mixed clinical controls (46 with unipolar depression and 53 with anxiety disorders) completed the Young Schema Questionnaire and comparison measures. Associations were investigated using univariate and multivariate analyses. Mean scores were compared with previously established benchmarks. Participants with bipolar disorder demonstrate elevated scores on most EMSs, many at an intermediate position between nonclinical and mixed clinical control groups. When controlling for depression, participants with bipolar disorder exceed those with unipolar depression on Approval-Seeking/Recognition-Seeking and Entitlement/Grandiosity. Bipolar group membership is predicted by high scores on Approval-Seeking/Recognition-Seeking and low scores on Emotional Inhibition and Abandonment. Women were overrepresented. Axis II traits were not assessed, nor were manic symptoms in the mixed clinical sample. Bipolar disorder is associated with a general activation of the EMSs. Approval-Seeking/Recognition-Seeking and Entitlement/Grandiosity seem to be particularly high, while Emotional Inhibition and Abandonment seem to be typically low. These EMS are highly consistent with characteristics of the bipolar spectrum. By demonstrating the activation of the EMSs, this study suggests that the EMS component of schema theory may be applied to bipolar disorder. Future research should explore how EMSs might interact with life events to trigger affective symptoms and, ultimately, the applicability of schema therapy to bipolar disorder. Copyright © 2011 Elsevier B.V. All rights reserved.

  1. Preliminary findings regarding overweight and obesity in pediatric bipolar disorder.

    Science.gov (United States)

    Goldstein, Benjamin I; Birmaher, Boris; Axelson, David A; Goldstein, Tina R; Esposito-Smythers, Christianne; Strober, Michael A; Hunt, Jeffrey; Leonard, Henrietta; Gill, Mary Kay; Iyengar, Satish; Grimm, Colleen; Yang, Mei; Ryan, Neal D; Keller, Martin B

    2008-12-01

    Overweight/obesity is highly prevalent among adults with bipolar disorder and has been associated with illness severity. Little is known regarding overweight/obesity among youth with bipolar disorder. Subjects were 348 youths aged 7 to 17 years who met DSM-IV criteria for bipolar I or bipolar II disorder or study-operationalized criteria for bipolar disorder not otherwise specified and were enrolled in the Course and Outcome of Bipolar Illness in Youth study. Age- and sex-adjusted body mass index was computed according to International Obesity Task Force cut points, based on self- and parent-reported height and weight, to determine overweight/obesity. The study was conducted from October 2000 to July 2006. Overweight/obesity was prevalent among 42% of subjects. The most robust predictors of overweight/obesity in a logistic regression model were younger age, nonwhite race, lifetime physical abuse, substance use disorders, psychiatric hospitalizations, and exposure to ≥ 2 medication classes associated with weight gain. The prevalence of overweight/obesity among youth with bipolar disorder may be modestly greater than in the general population. Moreover, similar to adults, overweight/obesity among youth with bipolar disorder may be associated with increased psychiatric burden. These preliminary findings underscore the importance of early identification of overweight/obesity among youth with bipolar disorder. Future studies are needed to clarify the direction of the associations between overweight/obesity and the identified predictors and to compare the prevalence of overweight/obesity among youth with bipolar disorder versus other psychiatric disorders. Copyright 2008 Physicians Postgraduate Press, Inc.

  2. A different perspective on bipolar disorder? : epidemiology, consequences, concept, and recognition of bipolar spectrum disorder in the general population

    NARCIS (Netherlands)

    Regeer, Eline Janet

    2008-01-01

    Bipolar disorder, or manic-depressive illness, is a mood disorder in which episodes of mania, hypomania and depression occur in alternation with intervals of normal mood. Bipolar disorder is typically a recurrent illness and may have serious consequences such as poor social and occupational

  3. Life events and bipolar disorder : The influence of life events on the onset and course of bipolar disorder

    NARCIS (Netherlands)

    Kemner, Sanne

    2017-01-01

    In the Netherlands, bipolar disorder (also known as manic-depressive illness) is diagnosed in approximately 2% of the population. The disorder is characterized by alternating periods of raised activity and (manic) mood and periods of reduced activity with lowered (depressed) mood. Bipolar disorder

  4. Eletrização de líquidos e sólidos : excessos de carga e efeito sobre as propriedades de superfície

    OpenAIRE

    Leandra Pereira dos Santos

    2013-01-01

    Resumo: Nesta tese, investigou-se a eletrização e os mecanismos de acúmulo de carga em gotas de água e filmes de polietileno, bem como, avaliou-se o efeito das cargas elétricas em algumas propriedades desses materiais. A eletrização de água foi realizada de duas formas: pelo contato com uma superfície metálica polarizada ou expondo as gotas de água a um potencial eletrostático criado através do ar por um eletrodo sem contato. Em ambos os casos, observou-se que a água adquire excesso de cargas...

  5. Análise dos padrões de veículos na logística urbana de cargas

    OpenAIRE

    Araújo, Fernando de

    2013-01-01

    O objetivo deste trabalho é analisar, com base na logística urbana de cargas, a viabilidade operacional do emprego de veículos urbanos de cargas (veículos com capacidade de carga líquida até 2,5 toneladas), com a utilização do software TransCAD. O estudo de caso foi realizado em uma empresa do segmento de atacado e distribuição, situada na cidade de Uberlândia/MG. Trata-se de uma empresa tradicional que opera há 60 anos, destacando-se no cenário brasileiro em processos de logística. Devido à ...

  6. Atenuación de paquetes de carga de espacio en LDPE por electrodos de la misma composición

    Directory of Open Access Journals (Sweden)

    Idalberto Tamayo Ávila

    2016-01-01

    Full Text Available En este trabajo se estudió la influencia de dos capas semiconductoras de Ethyl Vinyl Acetate (EVA y negro de humo (Carbon Black, sobre la formación y propagación de carga de espacio cuando se ponen en contacto con el polietileno de baja densidad (LDPE y se le aplican campos eléctricos elevados (100 kV/mm. Estas capas son usadas como contactos interno y externo con el polietileno reticulado (XLPE en cables de media tensión formando interfaces donde se acumula la carga. Si se usan capas semiconductoras de la misma composición química se atenúan los paquetes de carga y se retrasa el tiempo de propagación de los mismos a través del volumen de las muestras de LDPE.

  7. Resolução numérica de equações de transporte de cargas elétricas através de isolantes

    OpenAIRE

    Mariangela Tassinari de Figueiredo

    1988-01-01

    Apresentamos alguns métodos numéricos para a resolução das equações hiperbólicas que regem problemas de transporte de cargas elétricas em isolantes, aplicando-os a quatro problemas específicos: injeção de corrente por um contato ôhmico em uma amostra com voltagem constante aplicada; transporte de um pulso de cargas através de uma amostra em circuito aberto; transporte de um pulso de cargas através de uma amostra submetida a uma diferença de potencial constante (tempo de vôo); e, finalmente, d...

  8. Meta-Analysis of Amygdala Volumes in Children and Adolescents with Bipolar Disorder

    Science.gov (United States)

    Pfeifer, Jonathan C.; Welge, Jeffrey; Strakowski. Stephen M.; Adler, Caleb M.; Delbello, Melissa P.

    2008-01-01

    The size of amygdala of bipolar youths and adults is investigated using neuroimaging studies. Findings showed that smaller volumes of amygdala were observed in youths with bipolar youths compared with children and adolescents without bipolar disorder. The structural amygdala abnormalities in bipolar youths are examined further.

  9. Significado de cargas no trabalho sob a ótica de operacionais de limpeza Meaning of workload on the view of cleaning professionals

    Directory of Open Access Journals (Sweden)

    Júlia Trevisan Martins

    2013-01-01

    Full Text Available OBJETIVO: Analisar o significado das cargas de trabalho para operacionais de limpeza de uma unidade de Emergência/Pronto Socorro e identificar as estratégias que eles utilizam como proteção as essas cargas. MÉTODOS: Estudo descritivo, exploratório qualitativo, com a participação de 12 operacionais de limpeza. A coleta de dados foi realizada por meio de entrevistas semiestruturadas e as falas submetidas à análise de conteúdo em suas etapas: leitura, determinação das unidades de registro e significações, codificação e classificação; tratamento e interpretação dos resultados obtidos. RESULTADOS: Emergiram três categorias: carga vivenciada no trabalho relacionada com a materialidade interna, carga vivenciada no trabalho relacionada com a materialidade externa e estratégias de enfrentamento utilizadas para amenizar e/ou prevenir as cargas no trabalho. CONCLUSÃO: Os profissionais conhecem parcialmente as cargas as quais estão expostos e enfrentam-nas individualmente.OBJECTIVE: To reveal the meaning of work operational loads on the operational cleaning Emergency Unit / Emergency and identify the strategies that they use as the protection these loads. METHOD: Descriptive, exploratory and qualitative, with 12 operational cleaning. Data collection was conducted through semi-structured interviews and statements submitted to content analysis in its phases: reading, register units and meanings, coding and classification; results treatment and interpreting. RESULTS: Three categories emerged: Work load related to internal materiality, work load related to external materiality, and coping strategies used to mitigate or prevent workloads. CONCLUSION: Professionals knew workloads partially and used self coping strategies.

  10. As restrições enfrentadas na distribuição de cargas facionadas: estudo de caso

    Directory of Open Access Journals (Sweden)

    Gisele Correa Macário

    2017-02-01

    Full Text Available Com a crise econômica, empresas de transporte de cargas rodoviárias, acabaram perdendo espaço no mercado por falta de planejamento, qualidade em serviços, custos elevados com transbordo e falta de informação aos seus clientes. As empresas sobreviventes vêm se ajustando as tendências de mercado a fim de tornarem-se mais competitivas, buscando melhorias em seus níveis de serviços, oferecendo qualidade e pontualidade nas entregas e coletas, para isso contam com a tecnologia de softwares a fim de agilizar o ciclo do pedido e reduzirem custos operacionais. Este artigo objetiva analisar as restrições enfrentadas na distribuição de cargas fracionadas, em uma operação de HUB de uma empresa de grande porte, que atua como braço de apoio para a distribuição, nas regiões Metropolitanas da Grande São Paulo, bem como apresentar possíveis soluções práticas a partir de técnicas e conceitos da logística de distribuição alinhada à tecnologia do software de roteirização Road Show, demonstrando como o conhecimento técnico agrega valor ao negócio.

  11. A carga das doenças cardiovasculares no estado de Santa Catarina no ano de 2009

    Directory of Open Access Journals (Sweden)

    Jefferson Traebert

    Full Text Available RESUMO OBJETIVO: estimar a carga das doenças cardiovasculares no estado de Santa Catarina, Brasil. MÉTODOS: estudo ecológico cujas unidades de análise foram as nove macrorregiões de saúde do estado; foram estimados o número de anos de vida perdidos precocemente, o número de anos vividos com incapacidade e o número de anos de vida ajustados por incapacidade (DALYs para 2009. RESULTADOS: foram estimados 358.777 DALYs, a uma taxa de 5.852 DALYs/100 mil habitantes, 51,1% no sexo masculino; as faixas etárias que apresentaram maiores taxas de DALYs foram as de 60-69, 70-79 e 45-59 anos; as doenças que mais contribuíram para DALYs foram doenças isquêmicas do coração e cerebrovasculares; as macrorregiões com maiores taxas de DALYs foram Planalto Norte, Sul e Serra Catarinense. CONCLUSÃO: a alta carga das doenças cardiovasculares em Santa Catarina evidencia a necessidade de intensificar as ações de promoção de saúde e de prevenção em todas as macrorregiões do estado.

  12. Incidencia de la carga inicial de pesticidas en fruta sobre los niveles residuales en aceites esenciales cítricos

    Directory of Open Access Journals (Sweden)

    María I Montti

    2013-01-01

    Full Text Available En Argentina, la producción cítrica es muy importante. Para el control de enfermedades y plagas en las quintas y empaques son utilizados diferentes pesticidas. Los objetivos de este estudio fueron: optimizar diferentes metodologías analíticas para la determi- nación de residuos de pesticidas en fruta y aceite esencial, y determinar el efecto de la carga inicial sobre los aceites esenciales obtenidos durante el proceso industrial. La calibración se llevó a cabo con matriz adicionada debido al efecto matriz. Los mé- todos propuestos fueron selectivos, precisos, exactos y sensibles. La concentración de residuos encontrados en fruta fresca varió dependiendo del lote y pesticida. La persistencia en fruta postlavada, aceite pulido y descerado fue distinta para cada analito. Se observó una ligera reducción de los residuos en el aceite descerado debido probablemente a la partición de los mismos en la fase cerosa. Los resultados muestran que la carga inicial en la fruta es significante.

  13. Modelo no lineal en elementos finitos para muros livianos con entramados de acero sujetos a carga lateral

    Directory of Open Access Journals (Sweden)

    Carlos Andrés Gaviria M.

    2013-01-01

    Full Text Available En este artículo se presentan los resultados de una investigación que tuvo como propósito modelar con elementos finitos el comportamiento a cargas laterales de los muros livianos compuestos de un entramado típico de acero para diferentes materiales de revestimiento. Se inició con la recopilación de información de ensayos de caracterización en los elementos del muro y las conexiones entre estos, a partir de esta información y la investigación realizada por [1] se construyó un modelo de elementos finitos que considera el comportamiento no lineal de las conexiones entre los elementos. Este modelo fue ajustado con la información de los ensayos ante carga lateral realizados en probetas a escala real para cinco configuraciones de revestimiento. En este proceso se encontraron grandes diferencias entre los parámetros del modelo ajustado y los iniciales que son atribuidas a la interacción entre los componentes del muro liviano. La validación del modelo se realizó prediciendo los resultados experimentales de una nueva configuración en la cual se combinan varios materiales, obteniendo un error del 6.9%. Este resultado indica una buena capacidad de predicción del modelo para otras posibles configuraciones de revestimiento.

  14. SHAPIRO EFFECT IN INDUCTIVE QUANTUM CIRCUITS WITH CHARGE DISCRETENESS EFECTO SHAPIRO EN CIRCUITOS CUÁNTICOS INDUCTIVOS CON CARGA DISCRETA

    Directory of Open Access Journals (Sweden)

    Kristopher Chandía Valenzuela

    2006-08-01

    Full Text Available ABSTRACT As it is known, quantum inductive circuits with charge discreteness show Bloch-like oscillations in electrical current under a dc external voltage. In this paper, the effect of a superimposed ac voltage in the circuit is considered. The Shapiro effect is found to be related to the existence of resonance. Surprisingly, in the limit of low frequency (no resonance, the electrical averaged current exists and has always the same sign. Eventually this allows for an experimental method to measure discrete charge effect in quantum mesoscopic circuits.RESUMEN Es sabido que circuitos cuánticos inductivos con carga discreta, cuando se someten a un voltaje continuo externo, presentan oscilaciones de Bloch en la corriente. En este trabajo se considera, además, la superposición de un voltaje alterno en el circuito. El efecto Shapiro, relacionado con la existencia de resonancias, es encontrado de modo explícito. Sorprendentemente, en el límite de bajas frecuencias (sin resonancia la corriente eléctrica promediada existe y tiene siempre el mismo signo. Eventualmente, esto entrega un método experimental para medir los efectos de la discretización de la carga en circuitos cuánticos mesosocópicos.

  15. Polyphosphonium-based ion bipolar junction transistors.

    Science.gov (United States)

    Gabrielsson, Erik O; Tybrandt, Klas; Berggren, Magnus

    2014-11-01

    Advancements in the field of electronics during the past few decades have inspired the use of transistors in a diversity of research fields, including biology and medicine. However, signals in living organisms are not only carried by electrons but also through fluxes of ions and biomolecules. Thus, in order to implement the transistor functionality to control biological signals, devices that can modulate currents of ions and biomolecules, i.e., ionic transistors and diodes, are needed. One successful approach for modulation of ionic currents is to use oppositely charged ion-selective membranes to form so called ion bipolar junction transistors (IBJTs). Unfortunately, overall IBJT device performance has been hindered due to the typical low mobility of ions, large geometries of the ion bipolar junction materials, and the possibility of electric field enhanced (EFE) water dissociation in the junction. Here, we introduce a novel polyphosphonium-based anion-selective material into npn-type IBJTs. The new material does not show EFE water dissociation and therefore allows for a reduction of junction length down to 2 μm, which significantly improves the switching performance of the ion transistor to 2 s. The presented improvement in speed as well the simplified design will be useful for future development of advanced iontronic circuits employing IBJTs, for example, addressable drug-delivery devices.

  16. Loopy: The Political Ontology of Bipolar Disorder

    Directory of Open Access Journals (Sweden)

    RACHEL JANE LIEBERT

    2013-01-01

    Full Text Available This essay is at once a critical analysis, an experiment in form, and – with some irony – a cautionary tale. Triggered by the inclusion of prodromal diagnoses in the fifth edition of the Diagnostic and Statistical Manual of Mental Disorders, and the recent call by the United States’ (U.S. Obama administration for increased mental health screening, I argue that shifts toward identifying and intervening on one’s potential madness, or risk, circulate with/in the contemporary U.S. climate of intensified discipline and terror, and use Bipolar Disorder as a site to critically explore how and with what implications this circulation occurs. Specifically, I weave Massumi’s ‘political ontology of threat’ with the narrative of a woman diagnosed with Bipolar Disorder in order to trace the pre-emptive politics and affective logic of a risk-based approach to madness. I contend that the diagnosing and drugging of potential is a self-perpetuating loop that is personally and politically harmful, and consider alternatives to this burgeoning practice.

  17. Depression and Mania in Bipolar Disorder.

    Science.gov (United States)

    Tondo, Leonardo; Vázquez, Gustavo H; Baldessarini, Ross J

    2017-04-01

    Episode duration, recurrence rates, and time spent in manic and depressive phases of bipolar disorder (BD) is not well defined for subtypes of the disorder. We reviewed the course, timing, and duration of episodes of mania and depression among 1130 clinically treated DSM-IV-TR BD patients of various types, and compared duration and rates as well as total proportion of time in depressive versus manic episodes during 16.7 average years at risk. As expected, episodes of depressions were much longer than manias, but episode-duration did not differ among BD diagnostic types: I, II, with mainly mixed-episodes (BD-Mx), or with psychotic features (BD-P). Recurrence rates (episodes/year) and proportion of time in depression and their ratios to mania were highest in BD-II and BD-Mx subjects, with more manias/year in psychotic and BD-I subjects. In most BD-subtypes, except with psychotic features, there was more time in depressive than manic morbidity, owing mainly to longer depressive than manic episodes. The proportion of time in depression was highest among those who followed a predominant DMI course, whereas total time in mania was greatest in BD with psychotic features and BD-I. and with an MDI course. Subtypes of BD patients differed little in episode-duration, which was consistently much longer for depression. The findings underscore the limited control of bipolar depression with available treatments.

  18. Transtorno bipolar do humor e gênero Bipolar affective disorder and gender

    Directory of Open Access Journals (Sweden)

    Rodrigo da Silva Dias

    2006-01-01

    Full Text Available Embora o transtorno bipolar (TB ocorra quase igualmente em ambos os sexos, a fenomenologia e o curso da doença diferem no homem e na mulher. No entanto, há evidências de que mulheres bipolares, mais que os homens, apresentariam início mais tardio (em especial na quinta década de vida, ciclagem rápida, mais episódios depressivos, mais mania disfórica que eufórica, estados mistos e evolução do tipo bipolar II, ainda que os achados nem sempre sejam consistentes. Embora o risco de comorbidades no TB inclua, para ambos os gêneros, abuso de álcool e drogas, homens bipolares teriam maior probabilidade de ser alcoolistas, não procurar tratamento e de se suicidar. Hipóteses sugeridas para explicar tais diferenças variam daquelas centradas em aspectos culturais ou psicológicos para as que focalizam os sistemas hormonais, como os esteróides gonadais ou o eixo tireoidiano, e até mesmo a anatomia cerebral. A influência do ciclo reprodutivo (ciclo menstrual, gravidez e menopausa sobre as opções terapêuticas no tratamento do TB é apresentada na última parte desta revisão.Although the bipolar disorder (BD occurs almost with the same frequency in both genders, the phenomenology and the outcome of the illness differ between them. Nevertheless, there is evidence that women with BD show, more than men, delayed beginning, especially in their fifth decade, more rapid cycling outcome, more depressive episodes, more dysphoric mania, more mixed states and more BD type II. Even so, the findings are not always consistent. Although the risk of comorbidities in BD includes, for both the sorts, excessive alcoholic consumption and drugs, bipolar men would have greater probability of being alcohol dependent, of not seeking treatment and of committing suicide. Suggested hypotheses to explain such differences vary from those centered in cultural or psychological aspects to those that focus on the steroids hormones, and other hormones such as cortisol

  19. ESPECTROS DE CARGA DE CAMIONES PARA EL ANALISIS Y DISEÑO DE PAVIMENTOS EN LA REGIÓN ANDINA COLOMBIANA

    Directory of Open Access Journals (Sweden)

    Luis Macea

    2015-01-01

    Full Text Available Para el adecuado dimensionamiento de las estructuras de pavimento, se requiere la estimación de los efectos agrupados de las cargas del tránsito, por lo cual se debe conocer el número y tipo de vehículos que circularán por la vía, así como la intensidad del peso y la configuración del eje que la aplica, aspecto que es abordado cuando se hace la caracterización del tránsito a través de espectros de carga. En razón de esto en el presente artículo se construyen espectros de la capacidad por tipo de eje de camiones para diferentes rutas y departamentos de la región andina colombiana, de igual forma se Identifican los porcentajes de sobrecarga y las zonas donde se sobrepasa el límite máximo de peso permitido, así como los tipos de productos transportados en condiciones de exceso de peso. Para esto, se realizaron veintiséis (26 operativos de pesaje móvil de camiones en distintos corredores de carga de la región andina en el año 2013, con lo cual se obtuvo una muestra de 94.132 ejes pesados, a partir de los cuales se agruparon las capacidades por cada tipo de eje y se determinaron sus respectivas frecuencias de arrumaje. Los resultados encontrados indicaron que el eje sencillo direccional de llanta sencilla presenta un solo pico máximo con cierto grado de asimetría, el cual se encuentra regularmente por debajo de la carga máxima legal establecida para este tipo de eje, Por otro lado, los ejes sencillo de llanta doble presentan una bimodalidad con dos picos máximos muy parejos, uno en el sentido de las cargas bajas y el otro en el sentido de las cargas altas, mientras que los ejes tándem y tridem de llanta doble presentan una bimodalidad caracterizada por el predominio de un pico máximo absoluto del lado de las cargas altas lo que indica que los camiones están circulando con carga al límite permitido.

  20. La carga inmediata con implantes Microdent en el maxilar superior: I. Aspectos quirúrgicos Immediate loading with microdent implants in maxilla: I. Surgical step

    OpenAIRE

    E. Velasco Ortega; E. Fornés Ortuño; A. García Méndez; R. Medel Soteras; J. López Frías

    2007-01-01

    Introducción. El objetivo del presente trabajo era valorar el protocolo quirúrgico de la carga inmediata en el tratamiento con implantes oseointegrados del maxilar superior. La carga inmediata de los implantes orales para la rehabilitación del maxilar superior constituye una evaluación integral que incluye una valoración preoperatoria. Antes de la cirugía, las condiciones sistémicas y orales, así como el diagnóstico radiográfico (ortopantomografía y TAC) son obtenidos. La prevención antimicro...

  1. Correção do fator de potência de cargas industriais com dinâmica rápida

    OpenAIRE

    Marcos Cesar Isoni Silva

    2009-01-01

    Em alguns ramos de atividade do segmento industrial, bem como em edificações / complexos comerciais de médio e grande portes, contingentes significativos de equipamentos elétricos apresentam, como uma de suas principais características, uma rápida dinâmica operacional, alternando repetitivamente, e em curtos intervalos de tempo, estados de operação em vazio (ou em regime stand-by) e súbitas solicitações para funcionamento sob carga elevada ou cargaplena. Esses tipos carga apresentam, via de r...

  2. Avaliação da carga inorgânica de resinas compostas de conteúdo nanométrico

    OpenAIRE

    Hörlle, Lucas

    2009-01-01

    O objetivo deste estudo foi analisar a carga inorgânica de resinas compostas de conteúdo nanométrico. Foi determinando o conteúdo de carga em peso incorporado a cada material (TGA), o conteúdo inorgânico através da microscopia eletrônica de varredura (MEV), suas dimensões e morfologia, além dos componentes em peso pelo teste de Espectrografia por Dispersão de Raios X (EDS). As resinas compostas Esthet X, Filtek Supreme XT e Grandio foram divididas em seis grupos de acordo com a marca da resin...

  3. Contribuição da estrutura interna na perda de carga de filtros de areia utilizados na irrigação

    OpenAIRE

    Mesquita,Marcio; Testezlaf,Roberto; Salcedo,Juan C.; Bizari,Douglas R.

    2012-01-01

    A dinâmica de operação dos filtros de areia afeta o desempenho hidráulico do sistema de irrigação, elevando a perda de carga e alterando a altura manométrica total do sistema. Buscando entender parte dessa dinâmica, o objetivo deste trabalho foi determinar o efeito da estrutura interna de filtros de areia na perda de carga de três modelos de equipamentos fabricados no Brasil, sem a presença do elemento filtrante e utilizando água limpa. Adicionalmente, com o ajuste do modelo matemático expone...

  4. Estimación de la carga de enfermedad por incapacidad laboral permanente en España durante el período 2009-2012

    OpenAIRE

    María Andrée López; Xavier Duran; Jordi Alonso; José Miguel Martínez; Mireia Espallargues; Fernando G. Benavides

    2014-01-01

    Fundamentos: La incapacidad laboral permanente (IP) supone una importante carga social y económica. El objetivo de este estudio fue estimar la carga de enfermedad debida a la IP en España. Métodos: A partir de la Muestra Continua de Vidas Laborales (MCVL) se imputó como diagnóstico de la IP (2009-2012) el de la incapacidad temporal (IT) iniciada en 2009 en los individuos que cumplieron dos criterios: larga duración de la IT y corta duración del período entre la IT y la IP. Para los casos con ...

  5. Perda de carga em tubos de PVC conduzindo água residuária do processamento de café

    OpenAIRE

    Carvalho,Jacinto de A.; Aquino,Reinaldo F.; Pereira,Geraldo M.; Rodrigues,Reginaldo C.; Campos,Thiago B.

    2009-01-01

    Visando determinar a perda de carga distribuída e avaliar a variação dos coeficientes de atrito das equações Universal e de Hazen-Williams em tubulações comerciais de PVC, conduzindo águas residuárias do processamento do café (descascamento e demucilagem), ensaios foram conduzidos no Laboratório de Hidráulica do Departamento de Engenharia da Universidade Federal de Lavras, em que os resultados apontaram aumento do fator de atrito "f" e, conseqüentemente, da perda de carga, de 5 a 35% para águ...

  6. Factores de riesgo desencadenantes de patologías comunes y laborales en conductores de carga en una empresa transportadora de hidrocarburos en Colombia 2016

    OpenAIRE

    Ovalle Izquierdo, Ingrid Nathalia; Sotelo Zalamea, Luis Daniel

    2017-01-01

    RESUMEN INTRODUCCIÓN En Colombia y el mundo entero el personal de transporte de carga es numeroso, y un grupo importante para la economía de cada país por su demandante trabajo, por lo que es necesario mejorar las condiciones del puesto de trabajo de los transportadores, para prevenir enfermedades o lesiones y controlar los factores de riesgo. Algunos de los riesgos que se han asociado a los conductores de carga son gases de escape, ruido por encima de los niveles permisibles, vibracion...

  7. Carga de trabalho de enfermagem: preditor de infecção relacionada à assistência à saúde na terapia intensiva?

    OpenAIRE

    Nogueira,Lilia de Souza; Ferretti-Rebustini,Renata Eloah de Lucena; Poveda,Vanessa de Brito; Silva,Rita de Cassia Gengo e; Barbosa,Ricardo Luis; Oliveira,Elaine Machado de; Andolhe,Rafaela; Padilha,Kátia Grillo

    2015-01-01

    RESUMO Objetivo Analisar a influência da carga de trabalho de enfermagem na ocorrência de infecção relacionada à assistência à saúde (IRAS) em pacientes na Unidade de Terapia Intensiva (UTI), segundo o tipo de tratamento. Método Estudo de coorte retrospectivo desenvolvido em nove UTI em São Paulo, Brasil, de setembro a dezembro de 2012. A carga de trabalho de enfermagem foi mensurada pelo Nursing Activities Score (NAS). Os testes T-Student, Exato de Fisher e regressões logísticas foram ut...

  8. Algoritmo para otimização da sequência de acionamento de cargas elétricas em aeronaves

    OpenAIRE

    Augusto Marasca de Conto

    2009-01-01

    No projeto dos sistemas de uma aeronave o dimensionamento correto de seus componentes e do sistema como um todo são essenciais para a competitividade do produto. No projeto do sistema elétrico, um dos parâmetros utilizados é a corrente máxima que o sistema deve ser capaz de suportar. Quando um conjunto de cargas elétricas é acionado existe um consumo de corrente muito maior que o consumo normal de operação. Esta demanda deve ser suportada pelo sistema. O acionamento das cargas em uma sequênci...

  9. Avaliação de ensaio molecular para determinação de carga viral em indivíduos sorologicamente negativos para o HIV-1

    OpenAIRE

    Pereira,José Moreira; Silva,Cirley Santos da; Porto,Luís Fernando Bruzzi; Póvoa,Luiz Gallotti; Moreira,Aline Santos; Alves,Jorge Roberto

    2002-01-01

    O teste de carga viral foi concebido para acompanhar a evolução e o tratamento do paciente com diagnóstico confirmado de HIV-1. Contudo, sua especificidade diagnóstica não foi ainda avaliada em pessoas que apresentam um teste sorológico negativo. Mesmo assim, ele tem sido erroneamente utilizado para o diagnóstico da infecção primária pelo HIV-1. Este trabalho relata quatro pacientes em que a carga viral plasmática NucliSens (Organon Teknika) foi repetidamente positiva na ausência de anticorpo...

  10. OS SENTIDOS DA MASCULINIDADE NAS RELAÇÕES DE GÊNERO E A VIOLÊNCIA AFETIVO-CONJUGAL (THE SENSES OF THE MANLINESS IN THE RELATIONSHIPS OF GENDER AND THE AFFECTIONATE-MATRIMONIAL VIOLENCE

    Directory of Open Access Journals (Sweden)

    Sandra Maria Pinheiro de Freitas Coelho

    2007-01-01

    Full Text Available Resumo: O presente estudo busca refletir sobre as relações violentas cronificadas no âmbito afetivo/ conjugal a partir da construção da masculinidade, no contexto das relações de gênero, tendo por referência falas de homens pertencentes às camadas populares. Para este artigo elegemos a fala de um sujeito, analisada a partir de dados colhidos em entrevista semi-estruturada. O estudo apontou que as práticas heterossexuais violentas constroem-se a partir de significados atribuídos à masculinidade e à feminilidade que apresentam ambigüidades, tais como, afetividade, carinho, sedução, poder, raiva, virilidade, irracionalidade, racionalidade, entre outros sentimentos. Abstract: The present study it searchs to reflect about violent relationships in cronical situation inside affective environment from the construction of the masculinity, inside gender relations, having for reference as speak of pertaining men to the popular layers. For this article we choose says it of a citizen, analyzed from data harvested in half-structuralized interview. The study it pointed that the practical violent heterosexuals construct themselves from meanings attributed to the masculinity and the femininity that present ambiguities, such as, affectivity, affection, seduction, power, anger, virility, irrationality, rationality, among others feelings.

  11. Corpus callosum changes in euthymic bipolar affective disorder.

    Science.gov (United States)

    Lloyd, Adrian J; Ali, Heba E; Nesbitt, David; Moore, P Brian; Young, Allan H; Ferrier, I Nicol

    2014-02-01

    Changes in corpus callosum area and thickness have been reported in bipolar disorder. Imaging and limited neuropathological data suggest possible abnormalities in myelination and/or glial function. To compare corpus callosum area, thickness and magnetic resonance imaging (MRI) T1 signal intensity in patients with bipolar disorder and healthy controls. A total of 48 patients with euthymic bipolar disorder and 46 healthy controls underwent MRI analysis of callosal midsagittal area, callosal thickness and T1 signal intensity. The bipolar group had smaller overall and subregional callosal areas and correspondingly reduced callosal width than the control group. Age correlated negatively with callosal area in the control group but not in the bipolar group. Signal intensity was higher in women than in men in both groups. Signal intensity was reduced in women, but not in men, in the bipolar group. Observed differences probably relate to diagnosis rather than mood state and bipolar disorder appears to result in morphometric change that overrides changes seen in normal ageing. Intensity changes are consistent with possible altered myelination or glial function. A gender-dependent factor appears to operate and to interact with diagnosis.

  12. Bipolar disorder and dementia: where is the link?

    Science.gov (United States)

    Masouy, Anaïs; Chopard, Gilles; Vandel, Pierre; Magnin, Eloi; Rumbach, Lucien; Sechter, Daniel; Haffen, Emmanuel

    2011-03-01

    Cognitive disorders appearing in the course of bipolar disease have been identified, and recent studies have defined the neuropsychological characteristics of this pathology, which includes attention, executive function, memory and language disorders. However, questions remain concerning the appearance of dementia symptoms over the course of bipolar disorder in certain patients: is it a chance association or is there a connection between bipolar disorders and dementia? If the latter hypothesis is considered, what is the nature of the dementia, which might be considered as a dementia specific to bipolar disorder? Current clinical, neuropsychological and cerebral imaging data are inconclusive, but similarities with frontotemporal dementia might be highlighted. Functional imaging studies might provide answers as well as more specific tests in neuropsychology. The cause of cognitive damage in bipolar disease also raises questions concerning a neurodevelopmental or neurodegenerative process, because several factors seem to influence cognition and these two processes might occur simultaneously. Long-term studies are necessary to determine whether cognitive deterioration in bipolar disease is stable or progressive. There might also be different neurobiological subgroups of patients with bipolar disease. © 2011 The Authors. Psychogeriatrics © 2011 Japanese Psychogeriatric Society.

  13. Mental imagery as an emotional amplifier: application to bipolar disorder.

    Science.gov (United States)

    Holmes, Emily A; Geddes, John R; Colom, Francesc; Goodwin, Guy M

    2008-12-01

    Cognitions in the form of mental images have a more powerful impact on emotion than their verbal counterparts. This review synthesizes the cognitive science of imagery and emotion with transdiagnostic clinical research, yielding novel predictions for the basis of emotional volatility in bipolar disorder. Anxiety is extremely common in patients with bipolar disorder and is associated with increased dysfunction and suicidality, yet it is poorly understood and rarely treated. Mental imagery is a neglected aspect of bipolar anxiety although in anxiety disorders such as posttraumatic stress disorder and social phobia focusing on imagery has been crucial for the development of cognitive behavior therapy (CBT). In this review we present a cognitive model of imagery and emotion applied to bipolar disorder. Within this model mental imagery amplifies emotion, drawing on Clark's cyclical panic model [(1986). A cognitive approach to panic. Behaviour Research and Therapy, 24, 461-470]. We (1) emphasise imagery's amplification of anxiety (cycle one); (2) suggest that imagery amplifies the defining (hypo-) mania of bipolar disorder (cycle two), whereby the overly positive misinterpretation of triggers leads to mood elevation (escalated by imagery), increasing associated beliefs, goals, and action likelihood (all strengthened by imagery). Imagery suggests a unifying explanation for key unexplained features of bipolar disorder: ubiquitous anxiety, mood instability and creativity. Introducing imagery has novel implications for bipolar treatment innovation--an area where CBT improvements are much-needed.

  14. Treatment of Femoral Neck Fractures: Unipolar Versus Bipolar Hemiarthroplasty

    Directory of Open Access Journals (Sweden)

    Somashekar

    2013-07-01

    Full Text Available BACKGROUND AND OBJECTIVE: Intracapsular femoral neck fractures are common in the elderly population. To avoid the poor outcome of internal fixation and for early mobilization, hemiarthroplasty is performed. However, there is inadequate evidence to support the choice between unipolar or bipolar hemiarthroplasty. The aim of this study was to compare the outcome of unipolar with the bipolar prosthesis in geriatric patients. METHODS: Forty-one patients above 60 years of age and an acute displaced fracture of the femoral neck were randomly allocated to treatment by either unipolar or bipolar hemiarthroplasty, in the Department of Orthopaedics, between September 2009 and October 2012. Functional outcome was assessed and compared using Harris hip score and radiological parameters with a follow-up of one year. RESULTS: The two groups of patients with mean age of 67.3 in bipolar group and 75.6 in unipolar group did not differ in their pre-injury characteristics and perioperative parameters. The mean Harris hip score in bipolar and unipolar groups was 86.18±12.18 and 79.79±15.55, respectively (p=0.183; range of motion was 210.63±28.39 and 181.58±37(p=0.015 with bipolar and unipolar groups, respectively. Functional activities were better in the bipolar group. Complications like painful hip, posterior dislocation, periprosthetic fracture and acetabular erosion were encountered in unipolar prostheses. CONCLUSION: The use of bipolar endoprosthesis in the management of displaced femoral neck fractures in the elderly was associated with better mean Harris hip score and incidence of complications was limited. Hence, bipolar would be a better option in elderly patients with fracture neck of femur.

  15. Outpatient diagnosis and clinical presentation of bipolar youth.

    Science.gov (United States)

    Saxena, Kirti; Nakonezny, Paul A; Simmons, Alex; Mayes, Taryn; Walley, Annie; Emslie, Graham

    2009-08-01

    Many children and adolescents in the community do not fit the classic Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) criteria for Bipolar Disorder, Type I., and bipolar disorder, not otherwise specified (BPNOS) is often the "catch all" diagnosis. Significant research has been conducted to better understand the phenomenology of the spectrum of bipolar disorder; however, there are presently different operational definitions for bipolar disorder, in both clinical and research settings. A recent study, The Course and Outcome of Bipolar Youth (COBY) provided preliminary validation for diagnosing BPNOS. Using these COBY research definitions for BPNOS, we examined the clinical presentation and the prior history of psychotropic medication usage of youth with BPI vs. BPNOS presenting to an outpatient clinic. The initial evaluation consisted of a direct clinical interview with the parent(s) and the patient. Standardized rating scales such as the Young Mania Rating Scale and the Quick Inventory of Depressive Symptoms were used to assess current mood states. The Clinical Global Impressions Scale-Severity was used to assess the overall functioning of bipolar youth. Age, comorbidities, and family histories of 68 bipolar youth in the clinic are similar to what other studies have reported. BPNOS youth have significant functional impairment which is comparable to the BPI youth. Both bipolar groups are equally likely to have similar prior exposure to psychotropic medications. BPNOS is a serious illness the diagnostic guidelines for which are still debatable. Until further clarification of this diagnosis, the COBY definitions for BPNOS can be used in a clinic. The use of stringent criteria for diagnosing the bipolar spectrum disorders allows for careful differential diagnoses of psychiatric illnesses.

  16. Identifying early indicators in bipolar disorder: a qualitative study.

    Science.gov (United States)

    Benti, Liliane; Manicavasagar, Vijaya; Proudfoot, Judy; Parker, Gordon

    2014-06-01

    The identification of early markers has become a focus for early intervention in bipolar disorder. Using a retrospective, qualitative methodology, the present study compares the early experiences of participants with bipolar disorder to those with unipolar depression up until their first diagnosed episode. The study focuses on differences in early home and school environments as well as putative differences in personality characteristics between the two groups. Finally we a compare and contrast prodromal symptoms in these two populations. Thirty-nine participants, 20 diagnosed with unipolar depression and 19 diagnosed with bipolar disorder, took part in the study. A semi-structured interview was developed to elicit information about participants' experiences prior to their first episode. Participants with bipolar disorder reported disruptive home environments, driven personality features, greater emotion dysregulation and adverse experiences during the school years, whereas participants with depression tended to describe more supportive home environments, and more compliant and introvert personality traits. Retrospective data collection and no corroborative evidence from other family members. No distinction was made between bipolar I and bipolar II disorder nor between melancholic and non-melancholic depression in the sample. Finally the study spanned over a 12-month period which does not allow for the possibility of diagnostic reassignment of some of the bipolar participants to the unipolar condition. These findings indicate that there may be benefits in combining both proximal and distal indicators in identifying a bipolar disorder phenotype which, in turn, may be relevant to the development of early intervention programs for young people with bipolar disorder.

  17. Differential brain network activity across mood states in bipolar disorder.

    Science.gov (United States)

    Brady, Roscoe O; Tandon, Neeraj; Masters, Grace A; Margolis, Allison; Cohen, Bruce M; Keshavan, Matcheri; Öngür, Dost

    2017-01-01

    This study aimed to identify how the activity of large-scale brain networks differs between mood states in bipolar disorder. The authors measured spontaneous brain activity in subjects with bipolar disorder in mania and euthymia and compared these states to a healthy comparison population. 23 subjects with bipolar disorder type I in a manic episode, 24 euthymic bipolar I subjects, and 23 matched healthy comparison (HC) subjects underwent resting state fMRI scans. Using an existing parcellation of the whole brain, we measured functional connectivity between brain regions and identified significant differences between groups. In unbiased whole-brain analyses, functional connectivity between parietal, occipital, and frontal nodes within the dorsal attention network (DAN) were significantly greater in mania than euthymia or HC subjects. In the default mode network (DMN), connectivity between dorsal frontal nodes and the rest of the DMN differentiated both mood state and diagnosis. The bipolar groups were separate cohorts rather than subjects imaged longitudinally across mood states. Bipolar mood states are associated with highly significant alterations in connectivity in two large-scale brain networks. These same networks also differentiate bipolar mania and euthymia from a HC population. State related changes in DAN and DMN connectivity suggest a circuit based pathology underlying cognitive dysfunction as well as activity/reactivity in bipolar mania. Altered activities in neural networks may be biomarkers of bipolar disorder diagnosis and mood state that are accessible to neuromodulation and are promising novel targets for scientific investigation and possible clinical intervention. Copyright © 2016 Elsevier B.V. All rights reserved.

  18. Bipolar disorder and metabolic syndrome: an international perspective.

    Science.gov (United States)

    McIntyre, Roger S; Danilewitz, Marlon; Liauw, Samantha S; Kemp, David E; Nguyen, Ha T T; Kahn, Linda S; Kucyi, Aaron; Soczynska, Joanna K; Woldeyohannes, Hanna O; Lachowski, Angela; Kim, Byungsu; Nathanson, Jay; Alsuwaidan, Mohammad; Taylor, Valerie H

    2010-11-01

    The ubiquity and hazards posed by abnormal body composition and metabolic parameters in the bipolar population are a priority research and clinical issue. Herein, we summarize and synthesize international studies describing the rate of US National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III [ATP III])- and International Diabetes Federation (IDF)-defined metabolic syndrome and its criterion components in individuals with bipolar disorder. We conducted a PubMed search of all English-language articles published between January 2005 and July 2009 with the following search terms: metabolic syndrome and bipolar disorder, mania and manic-depression. Articles selected for review were based on adequacy of sample size, the use of standardized experimental procedures, validated assessment measures, and overall manuscript quality. The rate of metabolic syndrome in individuals with bipolar disorder is increased relative to the general population. Disparate estimates are reported ranging from comparability to approximately twofold greater than the general population. The increased hazard for metabolic syndrome amongst bipolar individuals is now documented in twelve countries from Europe, Australia, Asia, North and South America. The co-occurrence of metabolic syndrome in the bipolar population is associated with a more complex illness presentation, less favourable response to treatment, and adverse course and outcome. The association between metabolic syndrome and bipolar disorder is mediated/moderated by both iatrogenic and non-iatrogenic factors. The increased hazard for metabolic syndrome in bipolar populations is due to the clustering of traditional (and emerging) risk factors as well as iatrogenic and health systems factors. Extant data support recommendations for prioritizing, surveillance, prevention, diagnosis and management of metabolic syndrome as routine care

  19. Intervenções psicossociais no transtorno bipolar Psychosocial interventions for bipolar disorder

    Directory of Open Access Journals (Sweden)

    Luis Pereira Justo

    2004-01-01

    Full Text Available Neste trabalho, os autores, através de revisão bibliográfica narrativa, situam as intervenções psicossociais dentro do panorama terapêutico para o transtorno bipolar e constatam que ainda são insuficientes os estudos primários feitos com metodologia adequada para a obtenção de informações científicas de boa qualidade. São sucintamente descritos os trabalhos mais relevantes.In this paper, the authors review the status of psychosocial interventions within the general treatment for bipolar disorder. They have verified the scantiness of studies performed with adequate methodology to obtain scientific information of good quality. The more relevant studies are briefly described.

  20. Starting lithium prophylaxis early v. late in bipolar disorder

    DEFF Research Database (Denmark)

    Kessing, Lars Vedel; Vradi, Eleni; Andersen, Per Kragh

    2014-01-01

    BACKGROUND: No study has investigated when preventive treatment with lithium should be initiated in bipolar disorder. AIMS: To compare response rates among patients with bipolar disorder starting treatment with lithium early v. late. METHOD: Nationwide registers were used to identify all patients...... with a diagnosis of bipolar disorder in psychiatric hospital settings who were prescribed lithium during the period 1995-2012 in Denmark (n = 4714). Lithium responders were defined as patients who, following a stabilisation lithium start-up period of 6 months, continued lithium monotherapy without being admitted......-response to lithium compared with the rate for patients starting lithium later (adjusted analyses: first v. later contact: Pbipolar disorder: P

  1. [HOW TO EXPLORE BIPOLARITY IN CHILD PSYCHIATRY: A DIMENSIONAL SEMIOLOGY].

    Science.gov (United States)

    Scholl, J-M

    2016-02-01

    Despite its high frequency, bipolarity in childhood is little understood and is often diagnosed only after several years of development, and this during a time when the child's psychosocial future is at stake. A proper diagnosis requires recognition of accurate clinical signs. It is therefore essential to furnish clinicians with precise semiological markers. This paper presents a dimensional semiology for use in anamnesis and in clinical observation of the child. These clinical signs enable the identification of a bipolar manic temperament in the child and/or the identification of various different forms of childhood bipolar and depressive disorder. The relevant differential diagnoses and comorbidities are also presented.

  2. Paternal postpartum mood: bipolar episodes? Depressão paterna: episódio bipolar?

    OpenAIRE

    Karen Amaral Tavares Pinheiro; Fabio Monteiro da Cunha Coelho; Luciana de Ávila Quevedo; Karen Jansen; Luciano de Mattos Souza; Jean Pierre Oses; Bernardo Lessa Horta; Ricardo Azevedo da Silva; Ricardo Tavares Pinheiro

    2011-01-01

    OBJECTIVE: We describe the prevalence of depressive and bipolar spectrum episodes in fathers in antenatal and postnatal periods, as well as at 12 months after childbirth. METHOD: A longitudinal follow-up study was conducted with a representative sample of 739 fathers whose children were born between April 2007 and May 2008 in maternity wards in the city of Pelotas, southern Brazil. Paternal psychopathology was measured with the Mini Neuropsychiatric Interview (MINI) across three time points: ...

  3. Toward a complex system understanding of bipolar disorder: A chaotic model of abnormal circadian activity rhythms in euthymic bipolar disorder.

    Science.gov (United States)

    Hadaeghi, Fatemeh; Hashemi Golpayegani, Mohammad Reza; Jafari, Sajad; Murray, Greg

    2016-08-01

    In the absence of a comprehensive neural model to explain the underlying mechanisms of disturbed circadian function in bipolar disorder, mathematical modeling is a helpful tool. Here, circadian activity as a response to exogenous daily cycles is proposed to be the product of interactions between neuronal networks in cortical (cognitive processing) and subcortical (pacemaker) areas of the brain. To investigate the dynamical aspects of the link between disturbed circadian activity rhythms and abnormalities of neurotransmitter functioning in frontal areas of the brain, we developed a novel mathematical model of a chaotic system which represents fluctuations in circadian activity in bipolar disorder as changes in the model's parameters. A novel map-based chaotic system was developed to capture disturbances in circadian activity across the two extreme mood states of bipolar disorder. The model uses chaos theory to characterize interplay between neurotransmitter functions and rhythm generation; it aims to illuminate key activity phenomenology in bipolar disorder, including prolonged sleep intervals, decreased total activity and attenuated amplitude of the diurnal activity rhythm. To test our new cortical-circadian mathematical model of bipolar disorder, we utilized previously collected locomotor activity data recorded from normal subjects and bipolar patients by wrist-worn actigraphs. All control parameters in the proposed model have an important role in replicating the different aspects of circadian activity rhythm generation in the brain. The model can successfully replicate deviations in sleep/wake time intervals corresponding to manic and depressive episodes of bipolar disorder, in which one of the excitatory or inhibitory pathways is abnormally dominant. Although neuroimaging research has strongly implicated a reciprocal interaction between cortical and subcortical regions as pathogenic in bipolar disorder, this is the first model to mathematically represent this

  4. Nursing workload at a gastroenterology unit Carga de trabajo de enfermería en una unidad de gastroenterología Carga de trabalho de enfermagem em uma unidade de gastroenterologia

    Directory of Open Access Journals (Sweden)

    Marcia Raquel Panunto

    2009-12-01

    Full Text Available One of the biggest challenges nurses face is the need to justify the quantity and quality of staff for care delivery. For this, management instruments are available which help them to determine the staff needed in the nursing team. This descriptive study aims to evaluate the nursing workload at a specialized clinical and surgical gastroenterology unit. To collect data, the Nursing Activities Score (NAS was used during 30 consecutive days, with 1080 comments, obtained from the records of 149 patients. The mean NAS score was 34.9% and, considering that each point of NAS corresponds to 0.24 hour, on the average, 8.4 hours of nursing care were required within 24 hours. This means that this profile is of patients who demand intermediate and semi-intensive care, which suggests that the NAS study can be used to evaluate the workload of nurses at that unit.Uno de los mayores desafíos enfrentados por el enfermero se refiere a la necesidad de justificar la cantidad y calidad de personal que se necesita en una unidad para la prestación de asistencia. Para eso, dispone de herramientas administrativas que auxilian en la determinación del personal necesario en el equipo de enfermería. Se trata de un estudio descriptivo, que tuvo por objetivo evaluar la carga de trabajo de enfermería en una unidad clínica y quirúrgica, especializada en gastroenterología. Para la recolección de datos, se utilizó el Nursing Activities Score (NAS por 30 días consecutivos, totalizando 1.080 observaciones, obtenidas de los registros de 149 pacientes. El promedio de la puntuación del NAS fue de 34,9% y, considerando que cada punto del NAS corresponde a 0,24h, fueron requeridas, en promedio, 8,4 horas de enfermería para la asistencia en las 24h. Eso significa que el perfil de esos pacientes corresponde al de aquellos que requieren cuidados intermediarios y semi-intensivos, lo que sugiere que el NAS puede ser utilizado para evaluar la carga de trabajo de enfermería en la

  5. Carga de cáncer del departamento de Nariño y subregiones, Colombia, 2010

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    Elizabeth Trujillo-Montalvo

    2014-09-01

    Full Text Available Resumen Objetivo: medir la carga de cáncer a partir del indicador Años de Vida Saludables Perdidos (avisa en el Departamento de Nariño y subregiones. Metodología: mediante el uso de avisa, identificar la carga de cáncer en el departamento de Nariño, 2010. Resultados: Los avisa por cáncer en el Departamento de Nariño destacan la emergencia de los tumores de estómago, cuello uterino, mama, próstata, colon y recto, tráquea/bronquios/pulmón, benignos, las leucemias y linfomas, asimismo una suma importante de años de vida perdidos por muerte prematura y de predominio en mujeres. Conclusiones: este es el primer estudio de carga por cáncer de un departamento en Colombia usando una metodología estandarizada, que contribuye al Plan de Salud Departamental de Nariño, Colombia 2013-2015 y al sistema de indicadores del Plan Decenal para el Control del Cáncer. Los cánceres, luego de las enfermedades cardiovasculares, son las causas más importantes de avisa dentro del grupo de enfermedades no transmisibles. Abstract Objective: to measure the burden of cancer using the indicator Disability Adjusted Life Years (dalys. Methodology: the use of the dalys indicator made it possible to identify the burden of cancer in the department of Nariño, 2010. Results: the dalysdue to cancer emphasize the emergency of stomach, cervix, breast, prostate, trachea/bronchus/lung, colon and rectum and benign tumors, as well as leukemias and lymphomas. Similarly, the indicator shows an important amount of years of life lost due to premature death along with a predominance of this issue among women. Conclusions: this is the first study of burden of cancer targeting a department in Colombia using a standardized methodology contributing to the Health Plan of the department of Nariño in Colombia during 2013-2015 and to the indicators system of the Cancer Control Ten-Year Plan. Cancer is ranked second only to cardiovascular diseases as the most important causes of

  6. Capacidade de Suporte de Carga do Solo em Sistemas de Produção de Laranja Conservacionistas

    Directory of Open Access Journals (Sweden)

    Jonez Fidalski

    2015-06-01

    Full Text Available Sistemas conservacionistas em pomares de laranja podem aumentar a capacidade de suporte de carga do solo minimizando os seus riscos de compactação. O objetivo deste trabalho foi avaliar a capacidade de suporte de carga por meio da pressão de preconsolidação e sua dependência a conteúdo de água, densidade e carbono orgânico de um Argissolo Vermelho distrófico latossólico, após 18 anos de implantação de plantas de cobertura permanentes nas entrelinhas de um pomar de laranja. O delineamento experimental foi de blocos ao acaso, com três repetições. Foram estudados três tratamentos de manejo por meio de roçadas nas entrelinhas do pomar, desde o plantio do pomar em 1993: gramínea Paspalum notatum, leguminosa Arachis pintoi e vegetação espontânea. Cento e oito amostras indeformadas de solo foram coletadas em 2011 sob o rodado e entrerrodado das máquinas nas estrelinhas do pomar com textura arenosa nas camadas de 0,00-0,10 m (87 g kg-1 de argila e 0,10-0,20 m (122 g kg-1 de argila. Determinaram-se as pressões de preconsolidação das curvas de compressão do solo (25, 50, 100, 200, 400, 800 e 1.600 kPa em conteúdos de água sob três potenciais (-80, -330 e -1.000 hPa, a densidade do solo e o teor de carbono orgânico do solo. A pressão de preconsolidação não foi dependente do conteúdo de água, da densidade do solo e do teor de carbono orgânico do solo. A pressão de preconsolidação sob o rodado na camada de 0,00-0,10 m foi menor nos tratamentos leguminosa e vegetação espontânea. A manutenção permanente da gramínea manejada com roçadas nas entrelinhas do pomar de laranja proporcionou maior capacidade de suporte de carga do solo sob o rodado na camada superficial arenosa.

  7. Borderline personality-bipolar spectrum relationship.

    Science.gov (United States)

    Benazzi, Franco

    2006-01-01

    The relationship between borderline personality disorder (BPD) and bipolar disorders, especially bipolar-II disorder (BP-II), is unclear. Several reviews on the topic have come to opposite conclusions, i.e., that BPD is a bipolar spectrum disorder or instead that it is unrelated to bipolar disorders. Study aim was to find which items of BPD were related to BP-II, and which instead had no relationship with BP-II. An outpatient psychiatry private practice, more representative of mood disorders usually seen in clinical practice in Italy. INTERVIEWER: A senior clinical and mood disorder research psychiatrist. A consecutive sample of 138 BP-II and 71 major depressive disorder (MDD) remitted outpatients. ASSESSMENT INSTRUMENTS: The Structured Clinical Interview for DSM-IV Axis I Disorders-Clinician Version (SCID-CV) was used for diagnosing, the SCID-II Personality Questionnaire was used by patients to self-assess borderline personality traits. Interview methods: Patients were interviewed with the SCID-CV to diagnose BP-II and MDD. The questions of the Personality Questionnaire relative to borderline personality were self-assessed by patients. As clinically significant distress or impairment of functioning was not assessed by the questionnaire, a diagnosis of borderline personality disorder could not be made, but borderline personality traits (BPT) could be assessed (i.e., all DSM-IV BPD items but not the impairment criterion). BPT items were significantly more common in BP-II versus MDD. The best combination of sensitivity and specificity for predicting BP-II was found by using a cutoff number of BPT items > or =5: specificity was 71.4%, sensitivity was 45.9%. BPT (defined by > or =5 items) was present in 29.5% of MDD and in 46.3% of BP-II (p=0.019). Logistic regression of BP-II versus BPT items number found a significant association. Principal component factor analysis of BPT items found two orthogonal factors: "affective instability" including unstable mood, unstable

  8. HTC: May survive in bipolar world

    Directory of Open Access Journals (Sweden)

    Singh Netra Pal

    2016-01-01

    Full Text Available The core assets of HTC are people, innovations, and technology. But in the recent quarters, HTC has started retrenching people even from R&D divisions which are responsible for innovation and developing new technologies. It means HTC's core assets are depleting. HTC was known for its cutting edge technology of 16mp camera and high speed '4G' technology but performing badly in the last two and half year. Why is it so? Paper objectives are to identify reasons for its downfall of HTC, distress signals for HTC downfall, and possible revival strategies for survival of HTC in Bipolar world (Samsung and Apple of smartphones makers. In addition, research paper present eight research proposition/ questions with respect to present state of HTC and its future and possible answers to these research propositions/ questions. Research paper ends with concluding remarks in the context of HTC future.

  9. Cognitive dysfunction in bipolar disorder and schizophrenia

    DEFF Research Database (Denmark)

    Bortolato, Beatrice; Miskowiak, Kamilla W; Köhler, Cristiano A

    2015-01-01

    Cognitive impairment is a core feature of schizophrenia (SZ) and bipolar disorder (BD). A neurocognitive profile characterized by widespread cognitive deficits across multiple domains in the context of substantial intellectual impairment, which appears to antedate illness onset, is a replicated...... deterioration in either SZ or BD, some findings point to more severe cognitive deficits in patients with early illness onset across both disorders. A compromised pattern of cognitive functioning in individuals at familiar and/or clinical risk to psychosis as well as in first-degree relatives of BD patients...... suggests that early neurodevelopmental factors may play a role in the emergence of cognitive deficits in both disorders. Premorbid intellectual impairment in SZ and at least in a subgroup of patients with BD may be related to a shared genetically determined influence on neurodevelopment....

  10. Magnetoamplification in a bipolar magnetic junction transistor.

    Science.gov (United States)

    Rangaraju, N; Peters, J A; Wessels, B W

    2010-09-10

    We have demonstrated the first bipolar magnetic junction transistor using a dilute magnetic semiconductor. For an InMnAs p-n-p transistor magnetoamplification is observed at room temperature. The observed magnetoamplification is attributed to the magnetoresistance of the magnetic semiconductor InMnAs heterojunction. The magnetic field dependence of the transistor characteristics confirm that the magnetoamplification results from the junction magnetoresistance. To describe the experimentally observed transistor characteristics, we propose a modified Ebers-Moll model that includes a series magnetoresistance attributed to spin-selective conduction. The capability of magnetic field control of the amplification in an all-semiconductor transistor at room temperature potentially enables the creation of new computer logic architecture where the spin of the carriers is utilized.

  11. The underlying neurobiology of bipolar disorder

    Science.gov (United States)

    MANJI, HUSSEINI K; QUIROZ, JORGE A; PAYNE, JENNIFER L; SINGH, JASKARAN; LOPES, BARBARA P; VIEGAS, JENILEE S; ZARATE, CARLOS A

    2003-01-01

    Clinical studies over the past decades have attempted to uncover the biological factors mediating the pathophysiology of bipolar disorder (BD) utilizing a variety of biochemical and neuroendocrine strategies. Indeed, assessments of cerebrospinal fluid chemistry, neuroendocrine responses to pharmacological challenge, and neuroreceptor and transporter binding have demonstrated a number of abnormalities in the amine neurotransmitter systems in this disorder. However, recent studies have also implicated critical signal transduction pathways as being integral to the pathophysiology and treatment of BD, in addition to a growing body of data suggesting that impairments of neuroplasticity and cellular resilience may also underlie the pathophysiology of the disorder. It is thus noteworthy that mood stabilizers and antidepressants indirectly regulate a number of factors involved in cell survival pathways - including MAP kinases, CREB, BDNF and bcl-2 protein - and may thus bring about some of their delayed long-term beneficial effects via underappreciated neurotrophic effects. PMID:16946919

  12. [Disease mongering and bipolar disorder in Japan].

    Science.gov (United States)

    Ihara, Hiroshi

    2011-01-01

    ,600 in 2003. At the same time, antidepressant sales have sextupled, from\\14.5 billion in 1998 to\\87 billion in 2006, according to statistics from GlaxoSmithKline. Recently, the pharmaceutical industry has shifted its focus from depression to bipolar disorder. Historically, Japanese psychiatrists have been familiar with Emil Kraepelin's "manic depressive insanity" (1899), whose definition was much narrower than that of its contemporary counterpart, bipolar disorder. Thus far, perhaps due partly to the reference in Kraepelin's definition of "manic depressive" disorder, Japanese psychiatrists have rather conservatively prescribed mood stabilizers for persons with frequent mood swings. Japanese psychiatrists can learn a great deal from their experience with the aggressive marketing of antidepressants. In the case of depression, over-medication arguably did more harm than good. The same risk exists with bipolar disorder. Disease mongering may occur whenever the interests of a pharmaceutical company exceed the expected benefits from the proposed pharmacotherapy on those affected by the putative bipolar disorder. In cases that are not severe enough for aggressive medication, psychiatrists should propose natural alternatives, such as an alteration of lifestyle and psychotherapy.

  13. Autoamputation of Genitalia in Bipolar Patient

    Directory of Open Access Journals (Sweden)

    Vinod Sharma

    2017-01-01

    Full Text Available According to literature, genital self-mutilation (GSM is more commonly associated with psychosis as compared with self-mutilation as a whole. There have been many case reports of GSM in psychotic disorders. We describe herein a case of a Caucasian, employed, and married male suffering from bipolar disorder type II with history of self-mutilating behavior, who amputated his penis during symptom-free phase of his illness. Several features are reflected as risky elements for genital self-mutilation, for example, homosexual and transsexual tendencies, abandonment of the male genitals, lack of competent male for identification during childhood, feeling of guilt for sexual offences, and self-injuries in anamnesis. This report will highlight various factors responsible for self-mutilation in nonpsychotic and nondelusional person.

  14. Posttraumatic stress disorder and bipolar mood disorder

    OpenAIRE

    Machado Vieira, Rodrigo; Gauer, Gabriel J C

    2003-01-01

    O Transtorno Bipolar (THB) não é somente uma condição endógena. Severos eventos negativos durante a vida influenciam o desenvolvimento do primeiro episódio e alteram o curso do THB durante a vida. O Transtorno de Estresse Pós-Traumático (TEPT) é uma severa e incapacitante doença mental que afeta uma significativa parcela da população, em algum momento de suas vidas. A presença concomitante de TEPT e THB parece mais freqüente que anteriormente sugerido, e pacientes psicóticos com história de t...

  15. Compliance to treatment in bipolar disorder

    OpenAIRE

    Santin, Aida; Ceresér, Keila; Rosa, Adriane

    2005-01-01

    O transtorno bipolar (TB) é uma doença crônica, recorrente, presente em 1,5% da população, estando associada a altas taxas de mortalidade e prejuízos socioeconômicos. O lítio, a carbamazepina e o ácido valpróico são os estabilizadores de humor mais usados. Em tratamentos prolongados, como é o caso do TB, a má-adesão dos pacientes é uma das maiores dificuldades. Verifica-se que fatores ligados ao paciente, aos medicamentos e aos médicos possam ser responsáveis pela baixa adesão. A psicoeducaçã...

  16. Obesity and bipolar disorder: synergistic neurotoxic effects?

    Science.gov (United States)

    Liu, Celina S; Carvalho, André F; Mansur, Rodrigo B; McIntyre, Roger S

    2013-11-01

    Bipolar disorder (BD) is a disabling and chronic neuropsychiatric disorder that is typified by a complex illness presentation, episode recurrence and by its frequent association with psychiatric and medical comorbidities. Over the past decade, obesity has emerged as one of many comorbidities generating substantial concern in the BD population due to important prognostic implications. This comprehensive review details the bidirectional relationship between obesity and BD as evidenced by alterations in the structure and function of the central nervous system, in addition to greater depressive recurrence, cognitive dysfunction and risk of suicidality. Drawing on current research results, this article presents several putative mechanisms underlying the synergistic toxic effects and provides a framework for future treatment options for the obesity-BD comorbidity. There is a need for more large-scale prospective studies to investigate the bidirectional relationships between obesity and BD.

  17. As bases neurobiológicas do transtorno bipolar Neurobiological basis of bipolar disorder

    Directory of Open Access Journals (Sweden)

    Rodrigo Machado-Vieira

    2005-01-01

    Full Text Available Neste artigo, os autores revisam importantes aspectos associados às bases biológicas do transtorno de humor bipolar (THB. O THB está relacionado com o surgimento de diversas alterações bioquímicas e moleculares em sistemas de neurotransmissão e vias de segundos-mensageiros geradores de sinais intracelulares. Essas modificações em neurônios e glia parecem estar associadas com o surgimento de sintomas maníacos e depressivos. Ainda neste contexto, disfunções na homeostasia e no metabolismo energético cerebral tem sido associado com alterações comportamentais, na modulação do humor e ritmo circadiano em humanos e em modelos animais da doença. Assim, alterações metabólicas em neurônios e células gliais têm sido associadas com quadros depressivos e maníacos. Nos últimos anos, avanços nas técnicas de neuroimagem, genéticos e de biologia moleculares têm gerado novos conhecimentos acerca das bases biológicas da bipolaridade. Os autores destacam que a doença parece estar relacionada diretamente com disfunções em diferentes mecanismos adaptativos a estresse em células neurais, gerando perda na capacidade celular de induzir neuroplasticidade e neurotrofismo, facilitando assim o surgimento da doença.In this article, the authors review relevant aspects related to the neurobiological basis of bipolar disorder. This illness has been associated with complex biochemical and molecular changes in brain circuits linked to neurotransmission and intracellular signal transduction pathways, and changes on neurons and glia have been proposed to be directly associated with clinical presentation of mania and depression. In the same context, dysfunctions on brain homeostasis and energy metabolism have been associated with alterations on circadian rythms, behavior and mood in human and animal models of bipolarity. In the recent years, advances on techniques of neuroimaging, molecular biology and genetics has provided new insights about

  18. Diagnostic Precursors to Bipolar Disorder in Offspring of Parents With Bipolar Disorder: A Longitudinal Study.

    Science.gov (United States)

    Axelson, David; Goldstein, Benjamin; Goldstein, Tina; Monk, Kelly; Yu, Haifeng; Hickey, Mary Beth; Sakolsky, Dara; Diler, Rasim; Hafeman, Danella; Merranko, John; Iyengar, Satish; Brent, David; Kupfer, David; Birmaher, Boris

    2015-07-01

    The authors sought to identify diagnostic risk factors of manic, mixed, or hypomanic episodes in the offspring of parents with bipolar disorder ("high-risk offspring"). High-risk offspring 6-18 years old (N=391) and demographically matched offspring (N=248) of community parents without bipolar disorder were assessed longitudinally with standardized diagnostic instruments by staff blind to parental diagnoses. Follow-up assessments were completed in 91% of the offspring (mean follow-up interval, 2.5 years; mean follow-up duration, 6.8 years). Compared with community offspring, high-risk offspring had significantly higher rates of subthreshold mania or hypomania (13.3% compared with 1.2%), manic, mixed, or hypomanic episodes (9.2% compared with 0.8%), and major depressive episodes (32.0% compared with 14.9%). They also had higher rates of attention deficit hyperactivity disorder (30.7% compared with 18.1%), disruptive behavior disorders (27.4% compared with 15.3%), anxiety disorders (39.9% compared with 21.8%), and substance use disorders (19.9% compared with 10.1%), but not unipolar major depressive disorder (major depression with no bipolarity; 18.9% compared with 13.7%). Multivariate Cox regressions showed that in the high-risk offspring, subthreshold manic or hypomanic episodes (hazard ratio=2.29), major depressive episodes (hazard ratio=1.99), and disruptive behavior disorders (hazard ratio=2.12) were associated with subsequent manic, mixed, or hypomanic episodes. Only subthreshold manic or hypomanic episodes (hazard ratio=7.57) were associated when analyses were restricted to prospective data. Subthreshold manic or hypomanic episodes were a diagnostic risk factor for the development of manic, mixed, or hypomanic episodes in the offspring of parents with bipolar disorder and should be a target for clinical assessment and treatment research. Major depressive episodes and disruptive behavior disorders are also indications for close clinical monitoring of emergent

  19. Sexual behavior in women with bipolar disorder.

    Science.gov (United States)

    Mazza, Marianna; Harnic, Desiree; Catalano, Valeria; Di Nicola, Marco; Bruschi, Angelo; Bria, Pietro; Daniele, Antonio; Mazza, Salvatore

    2011-06-01

    There is a lack of studies regarding sexuality and sexual behavior in women with bipolar disorder. The aim of this study is to investigate sexual behavior in women affected by bipolar disorder in order to stimulate interest and debate in this area of care. Sixty women (30 BD I and 30 BD II) consent to participate in the study and were included in the sample. Moreover, sixty female healthy subjects without histories of psychiatric disorders were recruited as normal controls. Patients and healthy subjects were given the Sexual Interest and Sexual Performance Questionnaire, a questionnaire devised to explore various aspects of sexual behavior. The results of the present study suggest an increase of sexual interest in patients with BD I as compared both with BD II patients and healthy controls. In women with BD I such increase of interest was detected on some items of section I of the Sexual Interest and Sexual Performance Questionnaire, in particular "Actual Value of Sexuality" and "Implicit Sexual Interest", which implicitly explore sexual interest without overtly focusing upon sexual problems. Moreover, we observed a higher desired frequency of intercourse in women with BD I than BD II and a higher occurrence of repeated sexual intercourse in women with BD I than BD II. The main finding of the present study was an increase of sexual interest in BD I as compared with BD II female patients and normal controls. This result was detected when sexual interest was explored implicitly. Our study is limited by the small size of our subject groups. Further investigations on larger subject samples are needed to better clarify particular aspects of sexual behavior of BD patients. Copyright © 2010 Elsevier B.V. All rights reserved.

  20. IMPLICAÇÕES DOS MODELOS ASSISTENCIAIS DA ATENÇÃO BÁSICA NAS CARGAS DE TRABALHO DOS PROFISSIONAIS DE SAÚDE

    Directory of Open Access Journals (Sweden)

    Letícia de Lima Trindade

    2013-01-01

    Full Text Available Analiza la influencia de dos modelos asistenciales, que se utilizan en la atención primaria, en las cargas de trabajo de los profesionales de la salud. Investigación cualitativa realizada con los equipos de Salud de la Familia y el modelo tradicional detrabajar en Atención Primaria de Salud en el sur de Brasil. Para la obtención y procesamiento de los datos se utilizaron entrevistas, grupos focales y estudios documentales, analizados mediante la combinación de un análisis de contenido con el software AtlasTi. Los resultados mostraran que en ambos modelos, los problemas de organización y gestión de la asistencia, el exceso de demanda y la baja resolución son las principales fuentes de aumento de las cargas de trabajo, por locontrario como fuente de reducción de la carga laboral se presentaron la afinidad con el modelo de atención y el trabajo en equipo. Llegamos a la conclusión de que el aumento de la carga laboral en salud de la familia se vio afectada por la distancia entre lo prescrito y lo realizado, y en cuanto al modelo tradicional se debió a que este está basado en el modelo biomédico.

  1. Carga viral para citomegalovirus, en líquido de lavado bronquioalveolar, en población pediátrica

    Directory of Open Access Journals (Sweden)

    B H Aristizabal-Bernal

    2017-03-01

    Full Text Available INTRODUCCIÓN: las infecciones pulmonares son comunes en los pacientes inmunocomprometidos. La carga viral de citomegalovirus se utiliza de rutina para determinar en qué momento se debe iniciar la terapia preventiva en hospederos inmunocomprometidos, diagnosticar enfermedad activa y supervisar la repuesta a una terapia implementada.   OBJETIVO: describir el valor de la carga viral de citomegalovirus en líquido de lavado bronquioalveolar vs. sangre periférica en población pediátrica con signos de infección respiratoria.   MATERIALES Y MÉTODOS: estudio descriptivo, observacional de 16 pacientes pediátricos y 19 episodios, a quienes se les realizó, de manera simultánea, la carga viral de citomegalovirus en sangre y lavado bronquioalveolar.   RESULTADOS Y CONCLUSIONES: todas las cargas virales de citomegalovirus realizadas en lavado bronquioalveolar fueron positivas y en general se obtuvieron valores más elevados que en sangre, lo que sugiere una mayor sensibilidad de la prueba cuando se realiza en este tipo de muestra, en pacientes con sospecha clínica de infección respiratoria por citomegalovirus, lo cual la convierte en una ayuda diagnóstica importante según lo muestran los resultados obtenidos.

  2. APLICACIONES ADICIONALES DE LOS RESULTADOS DE PRUEBAS DE CARGA ESTÁTICAS EN EL DISEÑO GEOTÉCNICO DE CIMENTACIONES

    Directory of Open Access Journals (Sweden)

    YAMILE VALENCIA

    2012-01-01

    Full Text Available Generalmente las pruebas de carga no hacen parte de la rutina de obras de cimentaciones ejecutadas en Suramérica, y cuando son ejecutadas, el análisis queda restringido a la determinación o estimación de la capacidad de carga de la fundación. No obstante, pueden hacerse otros análisis de modo que el calculista cuente con mayores elementos de juicio en lo referente al comportamiento de la cimentación. El presente articulo muestra un conjunto de análisis complementarios, que pueden ser hechos a partir de los resultados obtenidos para una prueba de carga teniendo en cuenta el comportamiento característico de cada suelo y los mecanismos de interacción entre la estructura de cimentación y el suelo de soporte, a partir del análisis de los resultados de pruebas de carga realizadas sobre pilotes ejecutados con hélice continua.

  3. Towards a blood-based diagnostic panel for bipolar disorder

    NARCIS (Netherlands)

    F. Haenisch (Frieder); J.D. Cooper (Jason); A. Reif (Andreas); S. Kittel-Schneider (Sarah); J. Steiner (Johann); F.M. Leweke (Marcus); M. Rothermundt (Matthias); N.J.M. van Beveren (Nico); B. Crespo-Facorro (Benedicto); D. Niebuhr (David); D. Cowan (David); N. Weber (Natalya); R.H. Yolken (Robert); B.W.J.H. Penninx (Brenda W.J.H.); S. Bahn (Sabine)

    2015-01-01

    markdownabstract_Background:_ Bipolar disorder (BD) is a costly, devastating and life shortening mental disorder that is often misdiagnosed, especially on initial presentation. Misdiagnosis frequently results in ineffective treatment. We investigated the utility of a biomarker panel as a diagnostic

  4. Comorbidity of Bipolar Disorder and Multiple Sclerosis: A Case Report

    Directory of Open Access Journals (Sweden)

    Necla Keskin

    2013-08-01

    Full Text Available Multiple sclerosis is a chronic demyelinating disease of a central nervous system. Neuropsychiatric symptoms are common in multiple sclerosis and bipolar disorder is one of the most common psychiatric disorders that coexist with multiple sclerosis. Manic episodes may be the first presenting symptom of multiple sclerosis as comorbid pathology or as an adverse effect of pharmacotherapies used in multiple sclerosis. The comorbidity of bipolar disorder and multiple sclerosis is well-proven but its etiology is not known and investigated accurately. Recent studies support a common genetic susceptibility. Management of bipolar disorder in multiple sclerosis is based on evidence provided by case reports and treatment should be individualized. In this report, the association between bipolar disorder and multiple sclerosis, epidemiology, ethiology and treatment is discussed through a case had diagnosed as multiple sclerosis and had a manic episode with psychotic features. [Cukurova Med J 2013; 38(4.000: 832-836

  5. Discrete neurocognitive subgroups in fully or partially remitted bipolar disorder

    DEFF Research Database (Denmark)

    Jensen, Johan Høy; Knorr, Ulla; Vinberg, Maj

    2016-01-01

    controls. Hierarchical cluster analysis was conducted to determine whether there are discrete neurocognitive subgroups in bipolar disorder. The pattern of the cognitive deficits and the characteristics of patients in these neurocognitive subgroups were examined with analyses of covariance and least......BACKGROUND: Neurocognitive impairment in remitted patients with bipolar disorder contributes to functional disabilities. However, the pattern and impact of these deficits are unclear. METHODS: We pooled data from 193 fully or partially remitted patients with bipolar disorder and 110 healthy...... was cross-sectional which limits inferences regarding the causality of the findings. CONCLUSION: Globally and selectively impaired bipolar disorder patients displayed more functional disabilities than those who were cognitively intact. The present findings highlight a clinical need to systematically screen...

  6. State-related alterations of gene expression in bipolar disorder

    DEFF Research Database (Denmark)

    Munkholm, Klaus; Vinberg, Maj; Berk, Michael

    2012-01-01

    on comprehensive database searches for studies on gene expression in patients with bipolar disorder in specific mood states, was conducted. We searched Medline, Embase, PsycINFO, and The Cochrane Library, supplemented by manually searching reference lists from retrieved publications. Results:  A total of 17......Munkholm K, Vinberg M, Berk M, Kessing LV. State-related alterations of gene expression in bipolar disorder: a systematic review. Bipolar Disord 2012: 14: 684-696. © 2012 The Authors. Journal compilation © 2012 John Wiley & Sons A/S. Objective:  Alterations in gene expression in bipolar disorder...... have been found in numerous studies. It is unclear whether such alterations are related to specific mood states. As a biphasic disorder, mood state-related alterations in gene expression have the potential to point to markers of disease activity, and trait-related alterations might indicate...

  7. Increased risk of hyperthyroidism among patients hospitalized with bipolar disorder

    DEFF Research Database (Denmark)

    Thomsen, Anders F; Kessing, Lars V

    2005-01-01

    . METHODS: We conducted a historical cohort study using the Danish register data. The observational period was 1977--99. Three study cohorts were identified: all patients with a first hospital admission with resulting index discharge diagnoses of depression, bipolar disorder, or osteoarthritis. The risks......OBJECTIVES: Hyperthyroidism has been associated with affective disorder in many cross-sectional studies, but longitudinal studies in this connection are scarce. We assessed whether hospitalization with depressive disorder or bipolar disorder was a risk factor for development of hyperthyroidism...... with depressive disorder did not have an increased risk of hyperthyroidism, whereas patients with bipolar disorder had an increased of risk on the margin of statistical significance, when compared to patients with osteoarthritis. Patients with bipolar disorder had a significantly increased risk of hyperthyroidism...

  8. Precursor Parameter Identification for Insulated Gate Bipolar Transistor (IGBT) Prognostics

    Data.gov (United States)

    National Aeronautics and Space Administration — Precursor parameters have been identified to enable development of a prognostic approach for insulated gate bipolar transistors (IGBT). The IGBT were subjected to...

  9. Gender differences in the phenomenology of bipolar disorder

    DEFF Research Database (Denmark)

    Kessing, Lars Vedel

    2004-01-01

    OBJECTIVES: To investigate gender differences in the phenomenology of episodes in bipolar disorder as according to ICD-10. METHODS: All patients who got a diagnosis of a manic episode/bipolar disorder in a period from 1994 to 2002 at the first outpatient treatment ever or at the first discharge...... from psychiatric hospitalization ever in Denmark were identified in a nationwide register. RESULTS: Totally, 682 outpatients and 1037 inpatients got a diagnosis of a manic episode/bipolar disorder at the first contact ever. Significantly more women were treated as outpatients than as inpatients. Women...... patients treated during hospitalization more women than men presented with mixed episodes. CONCLUSIONS: Besides differences in the prevalence of mixed episodes and comorbid substance abuse few gender differences are found among patients presenting with a manic episode/bipolar disorder at first contact...

  10. Combinations of SNPs Related to Signal Transduction in Bipolar Disorder

    DEFF Research Database (Denmark)

    Koefoed, Pernille; Andreassen, Ole A; Bennike, Bente

    2011-01-01

    of complex diseases, it may be useful to look at combinations of genotypes. Genes related to signal transmission, e.g., ion channel genes, may be of interest in this respect in the context of bipolar disorder. In the present study, we analysed 803 SNPs in 55 genes related to aspects of signal transmission...... and calculated all combinations of three genotypes from the 3×803 SNP genotypes for 1355 controls and 607 patients with bipolar disorder. Four clusters of patient-specific combinations were identified. Permutation tests indicated that some of these combinations might be related to bipolar disorder. The WTCCC...... in the clusters in the two datasets. The present analyses of the combinations of SNP genotypes support a role for both genetic heterogeneity and interactions in the genetic architecture of bipolar disorder....

  11. Mortality and secular trend in the incidence of bipolar disorder

    DEFF Research Database (Denmark)

    Medici, Clara Reece; Videbech, Poul; Gustafsson, Lea Nørgreen

    2015-01-01

    BACKGROUND: The world-wide interest in bipolar disorder is illustrated by an exponential increase in publications on the disorder registered in Pubmed since 1990. This inspired an investigation of the epidemiology of bipolar disorder. METHODS: This was a register-based cohort study. All first......-ever diagnoses of bipolar disorder (International Classification of Diseases-10: F31) were identified in the nationwide Danish Psychiatric Central Research Register between 1995 and 2012. Causes of death were obtained from The Danish Register of Causes of Death. Age- and gender standardized incidence rates......, standardized mortality ratio (SMR) and Kaplan-Meier survival estimates were calculated. RESULTS: We identified 15,334 incident cases of bipolar disorder. The incidence rate increased from 18.5/100,000 person-years (PY) in 1995 to 28.4/100,000 PY in 2012. The mean age at time of diagnosis decreased...

  12. Do young adults with bipolar disorder benefit from early intervention?

    DEFF Research Database (Denmark)

    Kessing, Lars Vedel; Hansen, Hanne Vibe; Christensen, Ellen Margrethe

    2014-01-01

    BACKGROUND: It is unknown whether young adults with bipolar disorder are able to benefit from early intervention combining optimised pharmacological treatment and group psychoeducation. The aim of the present report was to compare the effects of early intervention among patients with bipolar...... disorder aged 18-25 years to that of patients aged 26 years or older. METHODS: Patients were randomised to early treatment in a specialised outpatient mood disorder clinic versus standard care. The primary outcome was risk of psychiatric re-hospitalisation. RESULTS: A total of 158 patients with mania/bipolar...... different, the observed differences of the point estimates was surprisingly larger for young adults suggesting that young adults with bipolar disorder may benefit even more than older adults from early intervention combining pharmacological treatment and group psychoeducation....

  13. Redox Dysregulation in the Pathophysiology of Schizophrenia and Bipolar Disorder

    DEFF Research Database (Denmark)

    Kulak, Anita; Steullet, Pascal; Cabungcal, Jan-Harry

    2013-01-01

    Abstract Significance: Schizophrenia (SZ) and bipolar disorder (BD) are classified as two distinct diseases. However, accumulating evidence shows that both disorders share genetic, pathological, and epidemiological characteristics. Based on genetic and functional findings, redox dysregulation due...

  14. Cognitive Impairment in Bipolar Disorder: Treatment and Prevention Strategies

    Science.gov (United States)

    Solé, Brisa; Jiménez, Esther; Torrent, Carla; Reinares, Maria; Bonnin, Caterina del Mar; Torres, Imma; Varo, Cristina; Grande, Iria; Valls, Elia; Salagre, Estela; Sanchez-Moreno, Jose; Martinez-Aran, Anabel; Carvalho, André F

    2017-01-01

    Abstract Over the last decade, there has been a growing appreciation of the importance of identifying and treating cognitive impairment associated with bipolar disorder, since it persists in remission periods. Evidence indicates that neurocognitive dysfunction may significantly influence patients’ psychosocial outcomes. An ever-increasing body of research seeks to achieve a better understanding of potential moderators contributing to cognitive impairment in bipolar disorder in order to develop prevention strategies and effective treatments. This review provides an overview of the available data from studies examining treatments for cognitive dysfunction in bipolar disorder as well as potential novel treatments, from both pharmacological and psychological perspectives. All these data encourage the development of further studies to find effective strategies to prevent and treat cognitive impairment associated with bipolar disorder. These efforts may ultimately lead to an improvement of psychosocial functioning in these patients. PMID:28498954

  15. Review of Heterojunctin Bipolar Transistor Structure, Applications, and Reliability

    Science.gov (United States)

    Lee, C.; Kayali, S.

    1993-01-01

    Heterojunction Bipolar Transistors (HBTs) are increasingly employed in high frequency, high linerity, and high efficiency applications. As the utilization of these devices becomes more widespread, their operation will be viewed with more scrutiny.

  16. International Society for Bipolar Disorders Task Force on Suicide

    DEFF Research Database (Denmark)

    Schaffer, Ayal; Isometsä, Erkki T; Tondo, Leonardo

    2015-01-01

    significantly associated with suicide attempts were: female gender, younger age at illness onset, depressive polarity of first illness episode, depressive polarity of current or most recent episode, comorbid anxiety disorder, any comorbid substance use disorder, alcohol use disorder, any illicit substance use......OBJECTIVES: Bipolar disorder is associated with a high risk of suicide attempts and suicide death. The main objective of the present study was to identify and quantify the demographic and clinical correlates of attempted and completed suicide in people with bipolar disorder. METHODS: Within...... the framework of the International Society for Bipolar Disorders Task Force on Suicide, a systematic review of articles published since 1980, characterized by the key terms bipolar disorder and 'suicide attempts' or 'suicide', was conducted, and data extracted for analysis from all eligible articles...

  17. The Dysregulated Brain : A psychoimmunological approach to bipolar disorder

    NARCIS (Netherlands)

    Haarman, Bartholomeus Cornelius Maria

    2017-01-01

    An important problem with psychiatric disorders is that much remains unknown about the underlying disease mechanisms, thereby delaying sometimes for many years the diagnosis bipolar disorder, with significant implications for treatment. In recent years, the neuroinflammation theory, which assumes

  18. The role of estrogen in bipolar disorder, a review

    DEFF Research Database (Denmark)

    Meinhard, Ninja; Kessing, Lars Vedel; Vinberg, Maj

    2014-01-01

    BACKGROUND: It appears that the female reproductive events and hormonal treatments may impact the course of bipolar disorder in women. In particular, childbirth is known to be associated with onset of affective episodes in women with bipolar disorder. During the female reproductive events the sex...... estrogen levels and women with bipolar disorder including studies of the anti manic effects of the selective estrogen receptor modulator tamoxifen. METHOD: A systematically literature search on PubMed was conducted: two studies regarding the connection between serum estrogen levels and women with bipolar...... disorder were identified. Furthermore, four studies were found concerning the antimanic effects of tamoxifen. RESULTS: Both studies in the estrogen studies showed very low levels of estrogen in women with postpartum psychosis and significant improvement of symptoms after treatment with estrogen. The four...

  19. The role of estrogen in bipolar disorder, a review

    DEFF Research Database (Denmark)

    Meinhard, Ninja; Kessing, Lars Vedel; Vinberg, Maj

    2014-01-01

    Background: It appears that the female reproductive events and hormonal treatments may impact the course of bipolar disorder in women. In particular, childbirth is known to be associated with onset of affective episodes in women with bipolar disorder. During the female reproductive events the sex...... estrogen levels and women with bipolar disorder including studies of the anti manic effects of the selective estrogen receptor modulator tamoxifen. Method: A systematically literature search on PubMed was conducted: two studies regarding the connection between serum estrogen levels and women with bipolar...... disorder were identified. Furthermore, four studies were found concerning the antimanic effects of tamoxifen. Results: Both studies in the estrogen studies showed very low levels of estrogen in women with postpartum psychosis and significant improvement of symptoms after treatment with estrogen. The four...

  20. GANGGUAN AFEKTIF BIPOLAR MANIA DENGAN PSIKOTIK: SEBUAH LAPORAN KASUS

    Directory of Open Access Journals (Sweden)

    Hendrikus Gede Surya Adhi Putra

    2015-05-01

    Full Text Available Gangguan bipolar merupakan gangguan yang terdiri dari afek yang meningkat, dan jugaaktivitas yang berlebih (mania atau hipomania, dan dalam jangka waktu yang berbedaterjadi penurunan afek yang disertai dengan penurunan aktivitas (depresi. Kejadianpada  gangguan  bipolar  berkisar  antara  0,3-1,5%.  Prevalensi  serupa  pada  pria  danwanita.Gejala gangguan bipolar episode manik meliputi perasaan sensitif, kurangistirahat, harga diri melonjak naik, dan pada episode depresi meliputi kehilanganminat, tidur lebih atau kurang dari normal, gelisah, merasa tidak berharga, dan kurangkonsentrasi. Laporan ini membahas kasus gangguan bipolar episode kini manik yangterjadi pada seorang laki-laki berusia 45 tahun. Pasien ini mendapatkan psikoterapi,haloperidol 1 x 5 mg, dan trihexyphenidyl 1 x 2 mg per oral.