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Sample records for aepr

  1. Anticonvulsant activity of alcoholic extract of bark of Pinus roxburghii Sarg.%西藏长叶松树皮乙醇提取物的抗惊厥作用

    Institute of Scientific and Technical Information of China (English)

    Dhirender Kaushik; Ajay Kumar; Pawan Kaushik; Avatar C.Rana

    2012-01-01

    目的:研究西藏长叶松树皮乙醇提取物(alcoholic extract of bark of Pinus roxburghii Sarg.,AEPR)的抗惊厥作用.方法:用最大电休克和戊四唑诱发白化Wistar大鼠癫痫.最大电休克模型经由大鼠耳电极给予150mA电流刺激0.2s诱发癫痫,以后肢强直性伸展持续时间的变化作为结局指标衡量AEPR的抗惊厥作用,即后肢强直性伸展持续时间减少或停止.戊四唑模型大鼠经腹膜内注射戊四唑诱发肌阵挛性发作和阵发性抽搐,以痉挛发作的延迟衡量AEPR的抗惊厥作用.结果:在最大电休克惊厥模型中,AEPR剂量分别为300和500 mg/kg体质量,均显著减轻所有阶段的大鼠惊厥发作(P<0.01);标准对照药物苯妥英钠组用量25 mg/kg,能显著减轻屈曲阶段的发作(P<0.01),并抑制所有阶段的惊厥发作.戊四唑惊厥模型大鼠于注射戊四唑前30min分别给予AEPR 300和500mg/kg,均能显著延迟阵挛性发作(P<0.01).100 mg/kg体质量的AEPR在戊四唑诱发的癫痫模型中没有显著的抗惊厥作用;标准对照药物地西泮4 mg/kg能大幅度延迟阵挛性发作.结论:本研究提示AEPR能有效抑制普遍强直性肌阵挛和部分癫痫发作.因此,AEPR对最大电休克及戊四唑诱发的大鼠癫痫有抗惊厥作用.然而需要进一步的研究确认是AEPR中的何种成分对这种抗惊厥作用起主导作用.%OBJECTIVE:To study the anticonvulsant activity of alcoholic extract of bark of Pinus roxburghii Sarg.(AEPR) used in Indian traditional medicine system in treating convulsion. METHODS:Anticonvulsant activity was evaluated by maximal electroshock (MES) and pentylenetetrazole (PTZ)-induced seizures in Wistar albino rats.In the MES model,150 mA current for 0.2 s was given through ear electrodes to induce convulsions in rats.The duration of tonic extension of hind limb was used as the end point,namely,prevention or decrease in the duration of hind limb extension was considered as a protective