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Sample records for aeg pruefreaktor pr-10

  1. AEG System -

    Data.gov (United States)

    Department of Transportation — The AEG System is used to create, revise, approve, and distribute text of the AEGS and Flight Standard Board (FSB)/Type Rating Report. The MMEL specifies under what...

  2. AEgIS

    CERN Multimedia

    CERN Video Productions

    2017-01-01

    During technical stop 2017 the AEgIS experiment was open for upgrades and maintenance. We had the opportunity to take some 360 images from inside and see where antiprotons are ¨trapped¨ and anti-Hydrogen produced.

  3. Lõigutud aeg / Vappu Thurlow

    Index Scriptorium Estoniae

    Thurlow, Vappu, 1960-

    2007-01-01

    Adamson-Ericu muuseumis kuni 25. XI avatud näitusest "Lõigutud aeg". Henri Bergsoni ajakäsitlusest. Töödest: Anu Juuraku "Suplejad", Ilkka Väätti "Kinaalda" ja "Ton", Aili Vahtrapuu "Vaagen vabale vaimule", Marje Üksise "Nii ma lähen", Annemie Bogaerts'i "Lõpp on vaikus", Siim-Tanel Annuse "24 tundi", Lynne Allen'i "Saak", Eve Kiileri "Ilu etalonide arhiivid", Ingrid Ledent'i "Mälu kestev olemine, mis muudab mineviku olevikuks", Raoul Kurvitza "Aeg ja lugu"

  4. Pae aeg Meistrite hoovis

    Index Scriptorium Estoniae

    2001-01-01

    Eesti Metallikunstnike Liidu näitus "Pae aeg". Näituse kujundaja ja algataja Urve Küttner. Osaleb 34 kunstnikku. Näha saab Helle Perensi paetahvlite kollektsiooni ja geoloogide leitud kivistisi. Avamisel anti Ede Kurreli nim. Metallikunstnike Liidu aastapreemia Urve Küttnerile

  5. AEgIS installation completed

    CERN Multimedia

    Katarina Anthony

    2012-01-01

    Gravity. Despite first being described over three centuries ago, it remains one of the least understood of the fundamental forces explored by physicists. At CERN’s recently completed AEgIS experiment, a team has set out to examine the effect of gravity on an as-yet-uncharted realm: antimatter.   The complete AEgIS set-up. Located in the AD hall, the AEgIS experiment plans to  make the first direct measurement of Earth’s gravitation effect on antimatter. By sending a beam of antihydrogen atoms through very thin gratings, the experiment will be able to measure how far the antihydrogen atoms fall and in how much time – giving the AEgIS team a measurement of the gravitational coupling. “By the end of 2012, we had finished by putting all the elements of the experiment together,” explains Michael Doser, AEgIS Spokesperson. “Now we have to show that they can all work together and, unfortunately, we will have no antiproton beams fo...

  6. The AEgIS experiment

    Energy Technology Data Exchange (ETDEWEB)

    Testera, G., E-mail: testera@ge.infn.it [Istituto Nazionale Fisica Nucleare (Italy); Aghion, S. [Politecnico of Milano (Italy); Amsler, C.; Ariga, A.; Ariga, T. [University of Bern, Laboratory for High Energy Physics, Albert Einstein Center for Fundamental Physics (Switzerland); Belov, A. [Institute for Nuclear Research of the Russian Academy of Science (Russian Federation); Bonomi, G. [University of Brescia, Department of Mechanical and Industrial Engineering (Italy); Braunig, P. [Heidelberg University, Kirchhoff-Institute for Physics (Germany); Bremer, J. [CERN, Physics Department (Switzerland); Brusa, R. [University of Trento, Department of Physics (Italy); Cabaret, L. [University of Paris-Sud, ENS Cachan, Laboratory Aimé Cotton, CNRS (France); Caccia, M. [INFN Milano (Italy); Caravita, R. [University of Genova, Department of Physics (Italy); Castelli, F. [INFN Milano (Italy); Cerchiari, G. [Max Planck Institute for Nuclear Physics (Germany); Chlouba, K. [Czech Technical University, Prague (Czech Republic); Cialdi, S. [INFN Milano (Italy); Comparat, D. [University of Paris-Sud, ENS Cachan, Laboratory Aimé Cotton, CNRS (France); Consolati, G. [Politecnico of Milano (Italy); Curreli, S. [Istituto Nazionale Fisica Nucleare (Italy); Collaboration: (AEgIS Collaboration); and others

    2015-08-15

    The AEgIS experiment is presently almost completely installed at CERN. It is currently taking data with antiprotons, electrons and positrons. The apparatus is designed to form a cold, pulsed beam of antihydrogen to measure the Earth’s gravitational acceleration g on antimatter and to perform spectroscopy measurements. This paper describes the main features of the apparatus and shows a selected review of some achieved results.

  7. AEgIS antihydrogen production trap

    CERN Multimedia

    Caraban Gonzalez, Noemi

    2017-01-01

    During technical stop 2017 the AEgIS experiment was open for upgrades and maintenance. We had the opportunity to take some 360 images from inside and see where antiprotons are ¨trapped¨ and anti-Hydrogen produced.

  8. Kurgiden aig = Kurgede aeg : [luuletused] / Nikolai Abramov

    Index Scriptorium Estoniae

    Abramov, Nikolai, 1961-

    2006-01-01

    Sisu: Kurgiden aig = Kurgede aeg ; Varastan sindai = Ootan sind ; Keväz̀ tuli = Kevad tuli ; Kibu = Valu ; "Miksh minä elän, miksh?..." = "Miks mina elan, miks?..." ; Vanh koir = Vana koer ; Ojat̀-randal = Ojati kaldal ; "Kül̀mi järven, kül̀mi jogen..." ; "Külmand järved, külmand jõed on..." ; "Uhostadud külä..." ; "Täis tuisand küla..." ; "Vaikastuiba lindud..." = "Vaikseks jäänud linnud..."

  9. Liikluses huligaanitsemine toob karmi karistuse / Raivo Aeg

    Index Scriptorium Estoniae

    Aeg, Raivo, 1962-

    2007-01-01

    Ilmunud ka: Põhjarannik, 22. mai 2007, lk. 2; Severnoje Poberezhje, 22. mai 2007, lk. 2; Oma Saar, 23. mai 2007, lk. 5; Postimees, 23. mai 2007, lk. 16; SL Õhtuleht, 23. mai 2007, lk. 12; Virumaa Teataja, 24. mai 2007, lk. 11; Vooremaa, 24. mai 2007, lk. 2; Koit, 24. mai 2007, lk. 6; Lõunaleht, 24. mai 2007, lk. 2; Võrumaa Teataja, 24. mai 2007, lk. 2; Den za Dnjom, 25. mai 2007, lk. 19; Harjumaa, 25. mai 2007, lk. 2; Vali Uudised, 25. mai 2007, lk. 2; Lääne Elu, 26. mai 2007, lk. 4; Järva Teataja, 29. mai 2007, lk. 2; Narvskaja Nedelja, 2. juuni 2007, lk. 4. Politseiameti peadirektor Raivo Aeg liiklusjärelevalve tõhustamisest, liikluskeskkonna ohutumaks muutmisest

  10. Erakordne aeg või valed mudelid? / Erik Aru

    Index Scriptorium Estoniae

    Aru, Erik

    2008-01-01

    Paul De Grauwe, Leonardo Iania ja Pablo Rovira Kaltwasser arvutasid välja börsidel erakordsemate päevade esinemise tõenäosuse. Nende järelduse kohaselt ei ole mitte praegune aeg erakordne, vaid finantsmudelid on valed. Lisa: Indeks Dow Jones Industrial Average oktoobrikuus

  11. Genome sequencing and annotation of multidrug resistant Mycobacterium tuberculosis (MDR-TB PR10 strain

    Directory of Open Access Journals (Sweden)

    Mohd Zakihalani A. Halim

    2016-03-01

    Full Text Available Here, we report the draft genome sequence and annotation of a multidrug resistant Mycobacterium tuberculosis strain PR10 (MDR-TB PR10 isolated from a patient diagnosed with tuberculosis. The size of the draft genome MDR-TB PR10 is 4.34 Mbp with 65.6% of G + C content and consists of 4637 predicted genes. The determinants were categorized by RAST into 400 subsystems with 4286 coding sequences and 50 RNAs. The whole genome shotgun project has been deposited at DDBJ/EMBL/GenBank under the accession number CP010968.

  12. Antihydrogen physics: gravitation and spectroscopy in AEgIS

    CERN Document Server

    Ferragut, R; Stroke, H H; Dassa, L; Rohne, O; Hogan, S D; Cialdi, S; Al-Qaradawi, I Y; Formaro, L; Sandaker, H; Testera, G; Stepanov, S V; Folegati, P; Morhard, C; Warring, U; Prelz, F; Belov, A S; Bonomi, G; Consolati, G; Ferrari, G; Lagomarsino, V; Krasnicky, D; Drobychev, G; Giammarchi, M G; Heyne, R; Zenoni, A; Castelli, F; Mariazzi, S; Cabaret, L; Fischer, A; Boscolo, I; Sillou, D; Villa, F; Perini, D; Djourelov, N; Zavatarelli, S; Oberthaler, M K; Manuzio, G; Carraro, C; Matveev, V A; Jorgensen, L V; Nedelec, P; Prevedelli, M; Comparat, D; Dupasquier, A; Turbabin, A V; Zvezhinskij, D S; Fontana, A; Kellerbauer, A; Canali, C; Dudarev, A; Petracek, V; Riccardi, C; Nebbia, G; Gninenko, S N; Brusa, R S; Rotondi, A; Sacerdoti, M; Calloni, A; Doser, M; Byakov, V M; Quasso, F; Trezzi, D

    2011-01-01

    AEgIS (Antimatter experiment: gravity, interferometry, spectroscopy) is an experiment approved by CERN with the goal of studying antihydrogen physics. In AEgIS, antihydrogen will be produced by charge exchange reactions of cold antiprotons with positronium atoms excited in a Rydberg state (n > 20). In the first phase of the experiment, controlled acceleration by an electric field gradient (Stark effect) and subsequent measurement of free fall in a Moire deflectometer will allow a test of the weak equivalence principle. In a second phase, the antihydrogen will be slowed, confined, and laser-cooled to perform CPT studies and detailed spectroscopy. In the present work, after a general description of the experiment, the present status of advancement will be reviewed, with special attention to the production and excitation of positronium atoms.

  13. Lõigutud aeg - "Impact 5" / Vappu Thurlow, Loit Jõekalda

    Index Scriptorium Estoniae

    Thurlow, Vappu, 1960-

    2006-01-01

    17.-21. 10. 2007 toimub Kumu Kunstimuuseumis rahvusvaheline graafikakonverents "Impact 5". Teema "Slices of Time / Lõigutud aeg" on tuletatud Henri Bergsoni filosoofiast. 4. XII toimus Adamson-Ericu muuseumis "Impact'i"-teemaline seminar. "Impact 5" logokonkursi võitis Heino Prunsvelt, II - Aapo Pukk. Kuraatorid tutvustavad küsimusi, mis võiksid olla mõtlemisaineks seoses "Impact'i" ja praeguse olukorraga ning tutvustavad lühidalt Henri Bergsoni filosoofilisi vaateid

  14. Emulsion detectors for the antihydrogen detection in AEgIS

    Energy Technology Data Exchange (ETDEWEB)

    Pistillo, C., E-mail: ciro.pistillo@cern.ch [University of Bern, Albert Einstein Center for Fundamental Physics, Laboratory for High Energy Physics (Switzerland); Aghion, S. [Politecnico of Milano (Italy); Amsler, C.; Ariga, A.; Ariga, T. [University of Bern, Albert Einstein Center for Fundamental Physics, Laboratory for High Energy Physics (Switzerland); Belov, A. [Institute for Nuclear Research of the Russian Academy of Science (Russian Federation); Bonomi, G. [University of Brescia, Department of Mechanical and Industrial Engineering (Italy); Bräunig, P. [Heidelberg University, Kirchhoff-Institute for Physics (Germany); Bremer, J. [CERN, Physics Department (Switzerland); Brusa, R. S. [University of Trento, Department of Physics (Italy); Cabaret, L. [University of Paris-Sud, Laboratory Aim Cotton, CNRS (France); Caccia, M. [INFN Milano (Italy); Caravita, R. [University of Genova, Department of Physics (Italy); Castelli, F. [INFN Milano (Italy); Cerchiari, G. [Max Planck Institute for Nuclear Physics (Germany); Chlouba, K. [Czech Technical University (Czech Republic); Cialdi, S. [INFN Milano (Italy); Comparat, D. [University of Paris-Sud, Laboratory Aim Cotton, CNRS (France); Consolati, G. [Politecnico of Milano (Italy); Demetrio, A. [Heidelberg University, Kirchhoff-Institute for Physics (Germany); and others

    2015-08-15

    The AEgIS experiment at CERN aims to perform the first direct measurement of gravitational interaction between matter and antimatter by measuring the deviation of a cold antihydrogen beam in the Earth gravitational field. The design of the experiment has been recently updated to include emulsion films as position sensitive detector. The submicrometric position accuracy of emulsions leads indeed to a significant improvement of the experimental sensitivity. We present results of preliminary tests and discuss perspectives for the final measurement.

  15. Astrocyte Elevated Gene-1 (AEG-1) Contributes to Non-thyroidal Illness Syndrome (NTIS) Associated with Hepatocellular Carcinoma (HCC).

    Science.gov (United States)

    Srivastava, Jyoti; Robertson, Chadia L; Gredler, Rachel; Siddiq, Ayesha; Rajasekaran, Devaraja; Akiel, Maaged A; Emdad, Luni; Mas, Valeria; Mukhopadhyay, Nitai D; Fisher, Paul B; Sarkar, Devanand

    2015-06-19

    Non-thyroidal illness syndrome (NTIS), characterized by low serum 3,5,3'-triiodothyronine (T3) with normal l-thyroxine (T4) levels, is associated with malignancy. Decreased activity of type I 5'-deiodinase (DIO1), which converts T4 to T3, contributes to NTIS. T3 binds to thyroid hormone receptor, which heterodimerizes with retinoid X receptor (RXR) and regulates transcription of target genes, such as DIO1. NF-κB activation by inflammatory cytokines inhibits DIO1 expression. The oncogene astrocyte elevated gene-1 (AEG-1) inhibits RXR-dependent transcription and activates NF-κB. Here, we interrogated the role of AEG-1 in NTIS in the context of hepatocellular carcinoma (HCC). T3-mediated gene regulation was analyzed in human HCC cells, with overexpression or knockdown of AEG-1, and primary hepatocytes from AEG-1 transgenic (Alb/AEG-1) and AEG-1 knock-out (AEG-1KO) mice. Serum T3 and T4 levels were checked in Alb/AEG-1 mice and human HCC patients. AEG-1 and DIO1 levels in human HCC samples were analyzed by immunohistochemistry. AEG-1 inhibited T3-mediated gene regulation in human HCC cells and mouse hepatocytes. AEG-1 overexpression repressed and AEG-1 knockdown induced DIO1 expression. An inverse correlation was observed between AEG-1 and DIO1 levels in human HCC patients. Low T3 with normal T4 was observed in the sera of HCC patients and Alb/AEG-1 mice. Inhibition of co-activator recruitment to RXR and activation of NF-κB were identified to play a role in AEG-1-mediated down-regulation of DIO1. AEG-1 thus might play a role in NTIS associated with HCC and other cancers.

  16. Astrocyte Elevated Gene-1 (AEG-1) Contributes to Non-thyroidal Illness Syndrome (NTIS) Associated with Hepatocellular Carcinoma (HCC)*

    Science.gov (United States)

    Srivastava, Jyoti; Robertson, Chadia L.; Gredler, Rachel; Siddiq, Ayesha; Rajasekaran, Devaraja; Akiel, Maaged A.; Emdad, Luni; Mas, Valeria; Mukhopadhyay, Nitai D.; Fisher, Paul B.; Sarkar, Devanand

    2015-01-01

    Non-thyroidal illness syndrome (NTIS), characterized by low serum 3,5,3′-triiodothyronine (T3) with normal l-thyroxine (T4) levels, is associated with malignancy. Decreased activity of type I 5′-deiodinase (DIO1), which converts T4 to T3, contributes to NTIS. T3 binds to thyroid hormone receptor, which heterodimerizes with retinoid X receptor (RXR) and regulates transcription of target genes, such as DIO1. NF-κB activation by inflammatory cytokines inhibits DIO1 expression. The oncogene astrocyte elevated gene-1 (AEG-1) inhibits RXR-dependent transcription and activates NF-κB. Here, we interrogated the role of AEG-1 in NTIS in the context of hepatocellular carcinoma (HCC). T3-mediated gene regulation was analyzed in human HCC cells, with overexpression or knockdown of AEG-1, and primary hepatocytes from AEG-1 transgenic (Alb/AEG-1) and AEG-1 knock-out (AEG-1KO) mice. Serum T3 and T4 levels were checked in Alb/AEG-1 mice and human HCC patients. AEG-1 and DIO1 levels in human HCC samples were analyzed by immunohistochemistry. AEG-1 inhibited T3-mediated gene regulation in human HCC cells and mouse hepatocytes. AEG-1 overexpression repressed and AEG-1 knockdown induced DIO1 expression. An inverse correlation was observed between AEG-1 and DIO1 levels in human HCC patients. Low T3 with normal T4 was observed in the sera of HCC patients and Alb/AEG-1 mice. Inhibition of co-activator recruitment to RXR and activation of NF-κB were identified to play a role in AEG-1-mediated down-regulation of DIO1. AEG-1 thus might play a role in NTIS associated with HCC and other cancers. PMID:25944909

  17. Evaluation of the Allergenicity Potential of TcPR-10 Protein from Theobroma cacao

    Science.gov (United States)

    Cardoso, Thyago Hermylly Santana; Pirovani, Carlos Priminho; Micheli, Fabienne; Noronha, Fátima Soares Motta; Alves, Andréa Catão; Faria, Ana Maria Caetano; da Silva Gesteira, Abelmon

    2012-01-01

    Background The pathogenesis related protein PR10 (TcPR-10), obtained from the Theobroma cacao-Moniliophthora perniciosa interaction library, presents antifungal activity against M. perniciosa and acts in vitro as a ribonuclease. However, despite its biotechnological potential, the TcPR-10 has the P-loop motif similar to those of some allergenic proteins such as Bet v 1 (Betula verrucosa) and Pru av 1 (Prunus avium). The insertion of mutations in this motif can produce proteins with reduced allergenic power. The objective of the present work was to evaluate the allergenic potential of the wild type and mutant recombinant TcPR-10 using bioinformatics tools and immunological assays. Methodology/Principal Findings Mutant substitutions (T10P, I30V, H45S) were inserted in the TcPR-10 gene by site-directed mutagenesis, cloned into pET28a and expressed in Escherichia coli BL21(DE3) cells. Changes in molecular surface caused by the mutant substitutions was evaluated by comparative protein modeling using the three-dimensional structure of the major cherry allergen, Pru av 1 as a template. The immunological assays were carried out in 8–12 week old female BALB/c mice. The mice were sensitized with the proteins (wild type and mutants) via subcutaneous and challenged intranasal for induction of allergic airway inflammation. Conclusions/Significance We showed that the wild TcPR-10 protein has allergenic potential, whereas the insertion of mutations produced proteins with reduced capacity of IgE production and cellular infiltration in the lungs. On the other hand, in vitro assays show that the TcPR-10 mutants still present antifungal and ribonuclease activity against M. perniciosa RNA. In conclusion, the mutant proteins present less allergenic potential than the wild TcPR-10, without the loss of interesting biotechnological properties. PMID:22768037

  18. Evaluation of the allergenicity potential of TcPR-10 protein from Theobroma cacao.

    Directory of Open Access Journals (Sweden)

    Sara Pereira Menezes

    Full Text Available BACKGROUND: The pathogenesis related protein PR10 (TcPR-10, obtained from the Theobroma cacao-Moniliophthora perniciosa interaction library, presents antifungal activity against M. perniciosa and acts in vitro as a ribonuclease. However, despite its biotechnological potential, the TcPR-10 has the P-loop motif similar to those of some allergenic proteins such as Bet v 1 (Betula verrucosa and Pru av 1 (Prunus avium. The insertion of mutations in this motif can produce proteins with reduced allergenic power. The objective of the present work was to evaluate the allergenic potential of the wild type and mutant recombinant TcPR-10 using bioinformatics tools and immunological assays. METHODOLOGY/PRINCIPAL FINDINGS: Mutant substitutions (T10P, I30V, H45S were inserted in the TcPR-10 gene by site-directed mutagenesis, cloned into pET28a and expressed in Escherichia coli BL21(DE3 cells. Changes in molecular surface caused by the mutant substitutions was evaluated by comparative protein modeling using the three-dimensional structure of the major cherry allergen, Pru av 1 as a template. The immunological assays were carried out in 8-12 week old female BALB/c mice. The mice were sensitized with the proteins (wild type and mutants via subcutaneous and challenged intranasal for induction of allergic airway inflammation. CONCLUSIONS/SIGNIFICANCE: We showed that the wild TcPR-10 protein has allergenic potential, whereas the insertion of mutations produced proteins with reduced capacity of IgE production and cellular infiltration in the lungs. On the other hand, in vitro assays show that the TcPR-10 mutants still present antifungal and ribonuclease activity against M. perniciosa RNA. In conclusion, the mutant proteins present less allergenic potential than the wild TcPR-10, without the loss of interesting biotechnological properties.

  19. Preparing for a Professional Career in the Geosciences with AEG

    Science.gov (United States)

    Barry, T.; Troost, K. G.

    2012-12-01

    The Association of Environmental and Engineering Geologists offers multiple resources to students and faculty about careers in the geosciences, such as description of what employers are looking for, career options, mentoring, and building your professional network. Our website provides easy access to these and other resources. Most of AEG's 3000 members found their first job through association with another AEG member and more than 75% of our membership is working in applied geoscience jobs. We know that employers are looking for the following qualities: passion for your career and the geosciences, an enthusiastic personality, flexibility, responsibility, ability to communicate well in oral and written modes, and the ability to work well in teams or independently. Employers want candidates with a strong well-rounded geoscience education and the following skills/experience: attendance at field camp, working knowledge of field methodologies, strong oral and written communication skills, basic to advanced computer skills, and the ability to conduct research. In addition, skill with GIS applications, computer modeling, and 40-hour OSHA training are desired. The most successful technique for finding a job is to have and use a network. Students can start building their network by attending regular AEG or other professional society monthly meetings, volunteering with the society, attending annual meetings, going on fieldtrips and participating in other events. Students should research what kind of job they want and build a list of potential preferred employers, then market themselves to people within those companies using networking opportunities. Word-of-mouth sharing of job openings is the most powerful tool for getting hired, and if students have name recognition established within their group of preferred employers, job interviews will occur at a faster rate than otherwise.

  20. Clonning and Expression of RgPR-10 Gene from Rehmannia glutinosa%地黄RgPR-10基因的克隆与表达

    Institute of Scientific and Technical Information of China (English)

    孙鹏; 郭玉海; 祁建军; 周丽莉; 张苗苗; 李先恩

    2009-01-01

    为研究地黄块根的发育机制,通过抑制消减杂交方法从地黄块根中克隆到一个多拷贝、含有完整阅读框编码154个氨基酸的RgPR-10基因(GenBank登录号为EU526395).表达分析发现地黄RgPR-10基因主要在根、茎中表达,尤其是块根中具有较高的表达量.序列分析发现该基因序列与其他物种相似性较低,可能具有不同的功能.为进一步研究该基因在地黄块根发育中的作用,对该基因进行了原核表达,并对融合蛋白进行了初步纯化,电泳检测纯化蛋白具有较高的纯度,可以用于下一步制备抗体和生化功能分析.

  1. AEG-1/MTDH/LYRIC: signaling pathways, downstream genes, interacting proteins, and regulation of tumor angiogenesis.

    Science.gov (United States)

    Emdad, Luni; Das, Swadesh K; Dasgupta, Santanu; Hu, Bin; Sarkar, Devanand; Fisher, Paul B

    2013-01-01

    Astrocyte elevated gene-1 (AEG-1), also known as metadherin (MTDH) and lysine-rich CEACAM1 coisolated (LYRIC), was initially cloned in 2002. AEG-1/MTDH/LYRIC has emerged as an important oncogene that is overexpressed in multiple types of human cancer. Expanded research on AEG-1/MTDH/LYRIC has established a functional role of this molecule in several crucial aspects of tumor progression, including transformation, proliferation, cell survival, evasion of apoptosis, migration and invasion, metastasis, angiogenesis, and chemoresistance. The multifunctional role of AEG-1/MTDH/LYRIC in tumor development and progression is associated with a number of signaling cascades, and recent studies identified several important interacting partners of AEG-1/MTDH/LYRIC in regulating cancer promotion and other biological functions. This review evaluates the current literature on AEG-1/MTDH/LYRIC function relative to signaling changes, interacting partners, and angiogenesis and highlights new perspectives of this molecule, indicating its potential as a significant target for the clinical treatment of various cancers and other diseases.

  2. Molecular cloning and expression analysis of hyp-1 type PR-10 family genes in Hypericum perforatum

    Directory of Open Access Journals (Sweden)

    Katja eKarppinen

    2016-04-01

    Full Text Available Hypericum perforatum L. is an important medicinal plant for the treatment of depression. The plant contains bioactive hypericins that accumulate in dark glands present especially in reproductive parts of the plant. In this study, pathogenesis-related class 10 (PR-10 family genes were identified in H. perforatum, including three previously unidentified members with sequence homology to hyp-1, a phenolic coupling protein that has earlier been suggested to participate in hypericin biosynthesis and binding/transportation. The PR-10 genes showed constitutive but variable expression patterns in different H. perforatum tissues. They were all expressed at relatively high levels in leaves, variably in roots and low levels in stem and reproductive parts of the plant with no association with dark glands. The gene expression was up-regulated in leaves after salicylic acid, abscisic acid and wounding treatments but with variable levels. To study exact location of the gene expression, in situ hybridization of hyp-1 transcripts was performed and the accumulation of the Hyp-1 protein was examined in various tissues. The presence of Hyp-1 protein in H. perforatum tissues mostly paralleled with the mRNA levels. In situ RNA hybridization localized the hyp-1 transcripts predominantly in vascular tissues in root and stem, while in leaf the mRNA levels were high also in mesophyll cells in addition to vasculature. Our results indicate that the studied PR-10 genes are likely to contribute to the defence responses in H. perforatum. Furthermore, despite the location of the hyp-1 transcripts in vasculature, no support for the transportation of the Hyp-1 protein to dark glands was found in the current study. The present results together with earlier data question the role of the hyp-1 as a key gene responsible for the hypericin biosynthesis in dark glands of H. perforatum.

  3. Molecular Cloning and Expression Analysis of hyp-1 Type PR-10 Family Genes in Hypericum perforatum.

    Science.gov (United States)

    Karppinen, Katja; Derzsó, Emese; Jaakola, Laura; Hohtola, Anja

    2016-01-01

    Hypericum perforatum L. is an important medicinal plant for the treatment of depression. The plant contains bioactive hypericins that accumulate in dark glands present especially in reproductive parts of the plant. In this study, pathogenesis-related class 10 (PR-10) family genes were identified in H. perforatum, including three previously unidentified members with sequence homology to hyp-1, a phenolic coupling protein that has earlier been suggested to participate in biosynthesis and binding/transportation of hypericin. The PR-10 genes showed constitutive but variable expression patterns in different H. perforatum tissues. They were all expressed at relatively high levels in leaves, variably in roots and low levels in stem and reproductive parts of the plant with no specific association with dark glands. The gene expression was up-regulated in leaves after salicylic acid, abscisic acid and wounding treatments but with variable levels. To study exact location of the gene expression, in situ hybridization of hyp-1 transcripts was performed and the accumulation of the Hyp-1 protein was examined in various tissues. The presence of Hyp-1 protein in H. perforatum tissues mostly paralleled with the mRNA levels. In situ RNA hybridization localized the hyp-1 transcripts predominantly in vascular tissues in root and stem, while in leaf the mRNA levels were high also in mesophyll cells in addition to vasculature. Our results indicate that the studied PR-10 genes are likely to contribute to the defense responses in H. perforatum. Furthermore, despite the location of the hyp-1 transcripts in vasculature, no support for the transportation of the Hyp-1 protein to dark glands was found in the current study. The present results together with earlier data question the role of the hyp-1 as a key gene responsible for the hypericin biosynthesis in dark glands of H. perforatum.

  4. Impacts of pr-10a Overexpression at the Molecular and the Phenotypic Level

    Directory of Open Access Journals (Sweden)

    Markus Göker

    2013-07-01

    Full Text Available Biotechnological approaches using genetic modifications such as homologous gene overexpression can be used to decode gene functions under well-defined circumstances. However, only the recording of the resulting phenotypes allows inferences about the impact of the modification on the organisms’ evolutionary, ecological or economic performance. We here compare a potato wild-type cell line with two genetically engineered cell cultures homologously overexpressing Pathogenesis Related Protein 10a (pr-10a. A detailed analysis of the relative gene-expression patterns of pr-10a and its regulators sebf and pti4 over time provides insights into the molecular response of heterotrophic cells to distinct osmotic and salt-stress conditions. Furthermore, this system serves as an exemplar for the tracing of respiration kinetics as a faster and more sensitive alternative to the laborious and time-consuming recording of growth curves. The utility and characteristics of the resulting data type and the requirements for its appropriate analysis are figured out. It is demonstrated how this novel type of phenotypic information together with the gene-expression-data provides valuable insights into the effect of genetic modifications on the behaviour of cells on both the molecular and the macroscopic level.

  5. On the way to measuring gbar with AEgIS

    CERN Document Server

    Palchoudhuri, Paroma

    2015-01-01

    The main goal of AEgIS is to measure the fall of antihydrogen in the Earth's gravitational eld, which is a direct test of Einstein's Weak Equivalence Principle. This gravity measurement requires the production of a pulsed and cold antihydrogen beam whose vertical de ection will be observed in a set of moire de ectometer gratings. The antihydrogen detector was previously built in order to measure the produc- tion and temperature of the antihydrogen atoms and for establishing the formation of the antihydrogen beam. This detector consist of scintillating bers that are con- nected to Multi-Pixel-Photon-Counters (MPPCs) which are further connected to readout electrons. For a total of 816 MPPCs, the bias voltage was tested. It was observed that one channel out of the 816 was not functional. Additionally, in the current setup antiprotons, which are used to produce anti- hydrogen, are cooled to 4 K using electrons. A uorescence spectroscopy technique that uses C 2 molecules to more efficiently cool antiprotons i...

  6. Molecular cloning and characterisation of a pathogenesis-related protein CsPR10 from Crocus sativus.

    Science.gov (United States)

    Gómez-Gómez, L; Rubio-Moraga, A; Ahrazem, O

    2011-03-01

    Plants have developed many mechanisms to protect themselves against most potential microbial pathogens and diseases. Among these mechanisms, pathogenesis-related proteins are produced as part of the active defence to prevent attack. In this study, a full-length cDNA encoding the CsPR10 protein was identified in fresh saffron stigmas (Crocus sativus). The deduced amino acid sequence from the nucleotide sequence of the coding region showed homology with PR10 proteins. The clone expressed as a protein in fusion with a GST tag produced a 47-kDa protein in E. coli. CsPR10 had ribonuclease activity, with features common to class II-type ribonucleases; its specific activity was quantified as 68.8 U·mg(-1) protein, thus falling within the range of most PR10 proteins exhibiting RNase activity. Antifungal activity of CsPR10 was assayed against Verticillium dahliae, Penicillium sp. and Fusarium oxysporum. CsPR10 inhibited only F. oxysporum growth, and antifungal potency was reflected in a IC(50) of 8.3 μm. Expression analysis showed the presence of high transcript levels in anther and tepal tissues, low levels in stigmas and roots, and no signal detected in leaves. This protein seems to be involved in the active defence response through activation of the jasmonic acid pathway.

  7. Crystal Structure of Hyp-1, a Hypericum perforatum PR-10 Protein, in Complex with Melatonin.

    Science.gov (United States)

    Sliwiak, Joanna; Dauter, Zbigniew; Jaskolski, Mariusz

    2016-01-01

    Hyp-1, a PR-10-fold protein from Hypericum perforatum, was crystallized in complex with melatonin (MEL). The structure confirms the conserved protein fold and the presence of three unusual ligand binding sites, two of which are internal chambers (1,2), while the third one (3) is formed as an invagination of the protein surface. The MEL ligand in site 1 is well defined while that in site 3 seems to be rotating between the side chains of Lys33 and Tyr150 that act as a molecular vise. The patch of electron density in site 2 does not allow unambiguous modeling of a melatonin molecule but suggests a possible presence of its degradation product. This pattern of ligand occupation is reproducible in repeated crystallization/structure determination experiments. Although the binding of melatonin by Hyp-1 does not appear to be very strong (for example, MEL cannot displace the artificial fluorescence probe ANS), it is strong enough to suggest a physiological role of this interaction. For example, trans-zeatin, which is a common ligand of PR-10 proteins, does not overcompete melatonin for binding to Hyp-1 as it does not affect the crystallization process of the Hyp-1/MEL complex, and among a number of potential natural mediators tested, melatonin was the only one to form a crystalline complex with Hyp-1 with the use of standard crystallization screens. Hyp-1 is the second protein in the Protein Data Bank for which melatonin binding has been demonstrated crystallographically, the first one being human quinone reductase.

  8. Crystal structure of Hyp-1, a Hypericum perforatum PR-10 protein, in complex with melatonin

    Directory of Open Access Journals (Sweden)

    Joanna eSliwiak

    2016-05-01

    Full Text Available Hyp-1, a PR-10-fold protein from H. perforatum, was crystallized in complex with melatonin (MEL. The structure confirms the conserved protein fold and the presence of three unusual ligand binding sites, two of which are internal chambers (1, 2, while the third one (3 is formed as an invagination of the protein surface. The MEL ligand in site 1 is well defined while that in site 3 seems to be rotating between the side chains of Lys33 and Tyr150 that act as a molecular vise. The patch of electron density in site 2 does not allow unambiguous modeling of a melatonin molecule but suggests a possible presence of its degradation product. This pattern of ligand occupation is reproducible in repeated crystallization/structure determination experiments. Although the binding of melatonin by Hyp-1 does not appear to be very strong (for example, MEL cannot displace the artificial fluorescence probe ANS, it is strong enough to suggest a physiological role of this interaction. For example, trans-zeatin, which is a common ligand of PR-10 proteins, does not overcompete melatonin for binding to Hyp-1 as it does not affect the crystallization process of the Hyp-1/MEL complex, and among a number of potential natural mediators tested, melatonin was the only one to form a crystalline complex with Hyp-1 with the use of standard crystallization screens. Hyp-1 is the second protein in the Protein Data Bank (PDB for which melatonin binding has been demonstrated crystallographically, the first one being human quinone reductase.

  9. Leaf-specific pathogenesis-related 10 homolog, PgPR-10.3, shows in silico binding affinity with several biologically important molecules

    Directory of Open Access Journals (Sweden)

    Jin Haeng Han

    2015-10-01

    Conclusion: Although ginseng PR-10.3 gene is expressed in all organs of 3-wk-old plantlets, its expression is restricted to leaves in mature 2-yr-old ginseng plants. The putative binding property of PgPR-10.3 with Re is intriguing. Further verification of binding affinity with other biologically important molecules in the large hydrophobic cavity of PgPR-10.3 may provide an insight into the biological features of PR-10 proteins.

  10. "aeg jookseb kiiresti nagu linnukoer..." : [luuletused] / Jaak Jõerüüt

    Index Scriptorium Estoniae

    Jõerüüt, Jaak, 1947-

    2003-01-01

    Sisu: "aeg jookseb kiiresti nagu linnukoer..." ; "hingele langes lund..." ; Eestis ; "minu esimesed luuletused sündisid siis kui vihma sadas..." ; "mina olen..." ; "kui Rooma jõudsin tabas mind masendus raske koorem langes õlgadele..." ; "Delfis jäi käimata, seal olevat hiilgav genius loci..."

  11. Pojehali, hüüab "Jääaeg 2" / Tiit Tuumalu

    Index Scriptorium Estoniae

    Tuumalu, Tiit, 1971-

    2006-01-01

    Täispikk animafilm "Jääaeg 2 : Suur sula" ("Ice Age 2 : The Meltdown") : režissöör Carlos Sandanha : eestikeelse dublaazhi režissöör Peeter Simm : Ameerika Ühendriigid 2006. Peeter Simm dublaazhi tegemisest

  12. "Jääaeg 2" : tiiger Diego kurvastas Marko Matveret / Jaanus Kulli

    Index Scriptorium Estoniae

    Kulli, Jaanus, 1955-

    2006-01-01

    Täispikk animafilm "Jääaeg 2 : Suur sula" ("Ice Age 2 : The Meltdown") : režissöör Carlos Sandanha : eestikeelse dublaazhi režissöör Peeter Simm : Ameerika Ühendriigid 2006. Filmi dubleerimisest dubleerijate kommentaaridega

  13. Astrocyte Elevated Gene-1 (AEG-1) Contributes to Non-thyroidal Illness Syndrome (NTIS) Associated with Hepatocellular Carcinoma (HCC)*

    OpenAIRE

    Srivastava, Jyoti; Robertson, Chadia L.; Gredler, Rachel; Siddiq, Ayesha; Rajasekaran, Devaraja; Akiel, Maaged A; Emdad, Luni; Mas, Valeria; Mukhopadhyay, Nitai D.; FISHER, PAUL B.; Sarkar, Devanand

    2015-01-01

    Background: Astrocyte elevated gene-1 (AEG-1) inhibits retinoid X receptor (RXR) function and is overexpressed in human hepatocellular carcinoma (HCC), which is associated with non-thyroidal illness syndrome (NTIS).

  14. Identification of european allergy patterns to the allergen families PR-10, LTP, and profilin from Rosaceae fruits.

    Science.gov (United States)

    Andersen, Maj-Britt Schmidt; Hall, Sharon; Dragsted, Lars Ove

    2011-08-01

    High fruit intakes are associated with significant health benefits but fruit allergy sufferers may be discouraged from eating fruit due to the symptoms they experience. Knowledge about allergens involved in fruit allergy and the frequent cross-reactions to other allergens is essential to (a) design the best strategy for fruit allergy testing (b) prescribe optimal avoidance diets, and (c) design technological solutions for development of hypoallergenic fruits. The objective of this review was to investigate whether some characteristic disease entities could be identified in Europe for allergy to Rosaceae fruits. Five allergy patterns were found involving the allergen families PR-10, LTP, and profilin. In the Western Mediterranean area allergies to Rosaceae fruits are caused by monosensitization to LTP, monosensitization to profilin, or co-sensitization to both these allergens. On the contrary, monosensitization to PR-10 and, to a lesser degree, co-sensitization to profilin and PR-10 is dominant in Northern and Central Europe. LTP sensitization is present both in pollinosis and non-pollinosis patients and is associated with peach allergy in particular. The disease pattern for patients sensitized to profilin is characterized by several concomitant allergies including grass and other pollens, Rosaceae and non-Rosaceae fruits. Finally, PR-10 sensitization is primarily associated to concomitant birch pollen and apple allergy.

  15. Plant pathogenesis-related proteins PR-10 and PR-14 as components of innate immunity system and ubiquitous allergens.

    Science.gov (United States)

    Ovchinnikova, Tatiana V; Finkina, Ekaterina I; Melnikova, Daria N; Bogdanov, Ivan V

    2016-10-26

    Pathogenesis-related (PR) proteins are components of innate immunity system in plants. They play an important role in plant defense against pathogens. Lipid transfer proteins (LTPs) and Bet v 1 homologues comprise two separate families of PR-proteins. Both LTPs (PR-14) and Bet v 1 homologues (PR-10) are multifunctional small proteins involving in plant response to abiotic and biotic stress conditions. The representatives of these PR-protein families do not show any sequence similarity but have other common biochemical features such as low molecular masses, the presence of hydrophobic cavities, ligand binding properties, and antimicrobial activities. Besides, many members of PR-10 and PR-14 families are ubiquitous plant panallergens which are able to cause sensitization of human immune system and cross-reactive allergic reactions to plant food and pollen. This review is aimed at comparative analysis of structure-functional and allergenic properties of the PR-10 and PR-14 families, as well as prospects for their medicinal application.

  16. Volumen y transparencia. AEG, Fagus, Bauhaus, evolución de un tema de esquina

    OpenAIRE

    García, Rafael

    2011-01-01

    Los edificios objeto de este estudio forman un conjunto ya clásico en su consideración como hitos en el proceso de la arquitectura moderna. Existe a este respecto una larga tradición historiográfica, comenzada por Pevsner', en la que se los presenta como eslabones de una misma cadena. Especialmente en los dos primeros, la fábrica de turbinas de la AEG y la Fagus, la comparación básica y casi ya tópica, se ha centrado en el carácter de sus esquinas, con alguna referencia ulterior al tratamient...

  17. Trigermanides AEGe{sub 3} (AE = Ca, Sr, Ba). Chemical bonding and superconductivity

    Energy Technology Data Exchange (ETDEWEB)

    Castillo, Rodrigo; Schnelle, Walter; Baranov, Alexey I.; Burkhardt, Ulrich; Bobnar, Matej; Cardoso-Gil, Raul; Schwarz, Ulrich; Grin, Yuri [Max-Planck-Institut fuer Chemische Physik Fester Stoffe, Dresden (Germany)

    2016-08-01

    The crystal structures of the trigermanides AEGe{sub 3}(tI32) (AE = Ca, Sr, Ba; space group I4/mmm, for SrGe{sub 3}: a = 7.7873(1), c = 12.0622(3) Aa) comprise Ge{sub 2} dumbbells forming layered Ge substructures which enclose embedded AE atoms. The chemical bonding analysis by application of the electron localizability approach reveals a substantial charge transfer from the AE atoms to the germanium substructure. The bonding within the dumbbells is of the covalent two-center type. A detailed analysis of SrGe{sub 3} reveals that the interaction on the bond-opposite side of the Ge{sub 2} groups is not lone pair-like - as it would be expected from the Zintl-like interpretation of the crystal structure with anionic Ge layers separated by alkaline-earth cations - but multi-center strongly polar between the Ge{sub 2} dumbbells and the adjacent metal atoms. Similar atomic interactions are present in CaGe{sub 3} and BaGe{sub 3}. The variation of the alkaline-earth metal has a merely insignificant influence on the superconducting transition temperatures in the s,p-electron compounds AEGe{sub 3}.

  18. Development of the Cryogenic System of AEgIS at CERN

    CERN Document Server

    Derking, J H; Burghart, G; Doser, M; Dudarev, A; Haider, S

    2014-01-01

    The AEgIS (Antimatter Experiment: Gravity, Interferometry, Spectroscopy) experiment is located at the antiproton decelerator complex of CERN. The main goal of the experiment is to perform the first direct measurement of the Earth’s gravitational acceleration on antihydrogen atoms within 1% precision. The antihydrogen is produced in a cylindrical Penning trap by combining antiprotons with positrons. To reach the precision of 1%, the antihydrogen has to be cooled to 100 mK to reduce its random velocity. A dilution refrigerator is selected to deliver the necessary cooling capacity of 100 μW at 50 mK. The AEgIS cryogenic system basically consists of cryostats for a 1-T and for a 5-T superconducting magnet, a central region cryostat, a dilution refrigerator cryostat and a measurement cryostat with a Moiré deflectometer to measure the gravitational acceleration. In autumn 2012, the 1-T cryostat, 5-T cryostat and central region cryostat were assembled and commissioned. The apparatus is cooled down in eight days ...

  19. Regulation of the localisation and function of the oncogene LYRIC/AEG-1 by ubiquitination at K486 and K491

    OpenAIRE

    Luxton, Hayley J.; Barnouin, Karin; Kelly, Gavin; Hanrahan, Sarah; Totty, Nick; Neal, David E.; Whitaker, Hayley C.

    2014-01-01

    The pivotal role of LYRIC/AEG-1 in malignant transformation, tumourigenesis and chemo-resistance has previously been demonstrated in different cell types and sub-cellular compartments. The localisation of LYRIC/AEG-1 appears crucial to its function and is regulated by three lysine-rich nuclear localisation signal regions, one of which was previously demonstrated to be modified by ubiquitin. Here we show that mutation of LYRIC/AEG-1 at K486 and K491 results in a loss of ubiquitination. A K486/...

  20. 2 ühe hoobiga. "Uskumatu Hulk", "Aeg on käes..." / Helmut Jänes

    Index Scriptorium Estoniae

    Jänes, Helmut, 1972-

    2008-01-01

    Seiklusfilm "Uskumatu Hulk" ("The Incredible Hulk") : režissöör Louis Leterrier : Ameerika Ühendriigid 2008 ja ulmefilm "Aeg on käes..." ("The Happening") : režissöör M. Night Shyamalan : peaosas Mark Wahlberg : Ameerika Ühendriigid - India 2008

  1. Combination of nanoparticle-delivered siRNA for Astrocyte elevated gene-1 (AEG-1) and all-trans retinoic acid (ATRA): an effective therapeutic strategy for hepatocellular carcinoma (HCC)

    Science.gov (United States)

    Rajasekaran, Devaraja; Srivastava, Jyoti; Ebeid, Kareem; Gredler, Rachel; Akiel, Maaged; Jariwala, Nidhi; Robertson, Chadia L.; Shen, Xue-Ning; Siddiq, Ayesha; Fisher, Paul B.; Salem, Aliasger K.; Sarkar, Devanand

    2016-01-01

    Hepatocellular carcinoma (HCC) is a fatal cancer with no effective therapy. Astrocyte elevated gene-1 (AEG-1) plays a pivotal role in hepatocarcinogenesis and inhibits retinoic acid-induced gene expression and cell death. Combination of a lentivirus expressing AEG-1 shRNA and all-trans retinoic acid (ATRA) profoundly and synergistically inhibited subcutaneous human HCC xenografts in nude mice. We now have developed liver-targeted nanoplexes by conjugating poly(amidoamine) (PAMAM) dendrimers with polyethylene glycol (PEG) and lactobionic acid (Gal) (PAMAM-PEG-Gal) which were complexed with AEG-1 siRNA (PAMAM-AEG-1si). The polymer conjugate was characterized by 1H-NMR, MALDI and mass spectrometry, and optimal nanoplex formulations were characterized for surface charge, size and morphology. Orthotopic xenografts of human HCC cell QGY-7703 expressing luciferase (QGY-luc) were established in the livers of athymic nude mice and tumor development was monitored by bioluminescence imaging (BLI). Tumor-bearing mice were treated with PAMAM-siCon, PAMAM-siCon+ATRA, PAMAM-AEG-1si and PAMAM-AEG-1si+ATRA. In the control group the tumor developed aggressively. ATRA showed little effect due to high AEG-1 levels in QGY-luc cells. PAMAM-AEG-1si showed significant reduction in tumor growth and the combination of PAMAM-AEG-1si+ATRA showed profound and synergistic inhibition so that the tumors were almost undetectable by BLI. A marked decrease in AEG-1 level was observed in tumor samples treated with PAMAM-AEG-1si. The group treated with PAMAM-AEG-1si+ATRA nanoplexes showed increased necrosis, inhibition of proliferation and increased apoptosis when compared to other groups. Liver is an ideal organ for RNAi therapy and ATRA is an approved anti-cancer agent. Our exciting observations suggest that the combinatorial approach might be an effective way to combat HCC. PMID:26079152

  2. A novel PR10 promoter from Erianthus arundinaceus directs high constitutive transgene expression and is enhanced upon wounding in heterologous plant systems.

    Science.gov (United States)

    Chakravarthi, M; Syamaladevi, Divya P; Harunipriya, P; Augustine, Sruthy Maria; Subramonian, N

    2016-01-01

    In genetic engineering, inducible promoters play an important role as the expression of genes driven by them can be turned on or off under situations like biotic or abiotic factors. There are few reports on inducible promoters that can be employed in the development of transgenic plants, particularly in sugarcane. In the present study, four wound inducible genes (Chitinase, PR1A, PR10 and HRGP) were selected and were amplified from Erianthus arundinaceus, a distant relative of sugarcane. In order to determine the gene that is highly induced upon wounding, RT-qPCR was performed, which showed that PR10 gene expression was instantaneous and higher upon wounding when compared to the other three genes. Using the random amplification of genomic ends technique, a 592 bp promoter sequence was obtained and in silico analysis of the upstream regulatory region revealed a 469 bp promoter and 123 bp of 5' untranslated region (UTR). Functional analyses of the promoter sequence (with and without 5' UTR) in tobacco, rice and sugarcane using β-glucuronidase (GUS) as the reporter gene revealed the constitutive and inducible nature of the PR10 promoter. Our studies have demonstrated that the PR10 promoter, though highly constitutive, was quickly induced upon wounding as well as on treatment with abscisic acid and methyl jasmonate hormones. This is the first report on the isolation and characterization of a PR10 promoter from a wild grass and is expected to have application for development of transgenic plants.

  3. Bioinformatics and Expression Pathogenesis-related Protein 10 Gene(SmPR-10) from Salvia miltiorrhiza Bunge%丹参病程相关蛋白基因(SmPR-10)的生物信息学及表达模式分析

    Institute of Scientific and Technical Information of China (English)

    生华; 刘梅; 化文平; 王喆之

    2011-01-01

    After analysis of Salvia miltiorrhiza EST sequences, one sequence was found had high homology with pathogenesis-related protein 10. The cDNA and DNA sequence of the gene were cloned and named as SmPR-10 (GenBank accession number: HM439764). SmPR10 without intron contained a single opening reading frame of 486 bp encoding 161 amino acid-peptides. SmPR-10 had a Bet v1 domain and was classed into the pathogenesis-related protein 10 family according to its sequence. Bioinformatics showed that the putative protein was a stable acidic protein with a predicted molecular weight of 17.47 kD. There were no signal peptides and transmembrane domains in SmPR-10. The Quantitative RT-PCR results revealed that SmPR-10 was expressed in different organs of S. miltiorrhiza,and could be induced by methyl jasmonate and pathogen. This suggested that SmPR-10 may be involved in plant defenses.%对丹参EST序列进行Blast分析,获得了一条病程相关蛋白10 (Pathogenesis-related protein 10,PR-10)基因,命名为:SmPR-10(GenBank注册号:HM439764).分别从cDNA和gDNA水平克隆得到该基因,其序列无内含子,包含一个长为486 bp的完整开放读码框,编码161个氨基酸残基.生物信息学分析显示,SmPR-10所编码的蛋白SmPR-10具有Bet v1结构域,属于病程相关蛋白10家族,其相对分子量为17.47 kD,为稳定的酸蛋白;无信号肽、膜锚定或跨膜结构域,为亲水性蛋白.实时定量PCR结果分析表明,SmPR-10基因主要在丹参茎中表达,其表达受到病原菌和茉莉酸甲酯逆境信号的诱导,显示SmPR-10基因可能在植物防御反应中发挥作用.

  4. Development of nuclear emulsions with 1 $\\mu$m spatial resolution for the AEgIS experiment

    CERN Document Server

    Kimura, M; Ahlén, O; Amsler, C; Ariga, A; Ariga, T; Belov, A.S; Bonomi, G; Bräunig, P; Bremer, J; Brusa, R.S; Burghart, G; Cabaret, L; Canali, C; Caravita, R; Castelli, F; Cerchiari, G; Cialdi, S; Comparat, D; Consolati, G; Di Domizio, S; Di Noto, L; Doser, M; Dudarev, A; Ereditato, A; Ferragut, R; Fontana, A; Genova, P; Giammarchi, M; Gligorova, A; Gninenko, S.N; Haider, S; Hogan, S.D; Huse, T; Jordan, E; Jørgensen, L.V; Kaltenbacher, T; Kawada, J; Kellerbauer, A; Knecht, A; Krasnický, D; Lagomarsino, V; Mariazzi, S; Matveev, V.A; Merkt, F; Moia, F; Nebbia, G; Nédélec, P; Oberthaler, M.K; Pacifico, N; Petrácek, V; Pistillo, C; Prelz, F; Prevedelli, M; Regenfus, C; Riccardi, C; Røhne, O; Rotondi, A; Sandaker, H; Scampoli, P; Spacek, M; Storey, J; Subieta Vasquez, M.A; Testera, G; Trezzi, D; Vaccarone, R; Zavatarelli, S

    2013-01-01

    The main goal of the AEgIS experiment at CERN is to test the weak equivalence principle for antimatter. We will measure the Earth ' s gravitational acceleration g with antihydrogen atoms being launched in a horizontal vacuum tube and traversing a moiré de fl ectometer. We intend to use a position sensitive device made of nuclear emulsions (combined with a time-of- fl ight detector such as silicon μ strips) to measure precisely their annihilation points at the end of the tube. The goal is to determine g with a 1% relative accuracy. In 2012 we tested emulsion fi lms in vacuum and at room temperature with low energy antiprotons from the CERN antiproton decelerator. First results on the expected performance for AEgIS are presented

  5. Development of nuclear emulsions with 1μm spatial resolution for the AEgIS experiment

    Energy Technology Data Exchange (ETDEWEB)

    Kimura, M. [Albert Einstein Center for Fundamental Physics, Laboratory for High Energy Physics, University of Bern, 3012 Bern (Switzerland); Aghion, S. [Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano (Italy); Istituto Nazionale di Fisica Nucleare, Sez. di Milano, Via Celoria 16, 20133 Milano (Italy); Ahlén, O. [European Organisation for Nuclear Research, Physics Department, 1211 Geneva 23 (Switzerland); Amsler, C., E-mail: claude.amsler@cern.ch [Albert Einstein Center for Fundamental Physics, Laboratory for High Energy Physics, University of Bern, 3012 Bern (Switzerland); Ariga, A.; Ariga, T. [Albert Einstein Center for Fundamental Physics, Laboratory for High Energy Physics, University of Bern, 3012 Bern (Switzerland); Belov, A.S. [Institute for Nuclear Research of the Russian Academy of Sciences, Moscow 117312 (Russian Federation); Bonomi, G. [University of Brescia, Department of Mechanical and Industrial Engineering, Via Branze 38, 25133 Brescia (Italy); Istituto Nazionale di Fisica Nucleare, Sez. di Pavia, Via Agostino Bassi 6, 27100 Pavia (Italy); Bräunig, P. [University of Heidelberg, Kirchhoff Institute for Physics, Im Neuenheimer Feld 227, 69120 Heidelberg (Germany); Bremer, J. [European Organisation for Nuclear Research, Physics Department, 1211 Geneva 23 (Switzerland); Brusa, R.S. [Dipartimento di Fisica, Università di Trento and INFN, Gruppo Collegato di Trento, Via Sommarive 14, 38050 Povo, Trento (Italy); Burghart, G. [European Organisation for Nuclear Research, Physics Department, 1211 Geneva 23 (Switzerland); Cabaret, L. [Laboratoire Aimé Cotton, CNRS, Université Paris Sud, ENS Cachan, Bâtiment 505, Campus d' Orsay, 91405 Orsay Cedex (France); Canali, C. [University of Zurich, Physics Institute, Winterthurerstrasse 190, 8057 Zurich (Switzerland); and others

    2013-12-21

    The main goal of the AEgIS experiment at CERN is to test the weak equivalence principle for antimatter. We will measure the Earth's gravitational acceleration g{sup ¯} with antihydrogen atoms being launched in a horizontal vacuum tube and traversing a moiré deflectometer. We intend to use a position sensitive device made of nuclear emulsions (combined with a time-of-flight detector such as silicon μ-strips) to measure precisely their annihilation points at the end of the tube. The goal is to determine g{sup ¯} with a 1% relative accuracy. In 2012 we tested emulsion films in vacuum and at room temperature with low energy antiprotons from the CERN antiproton decelerator. First results on the expected performance for AEgIS are presented.

  6. Euroopa Inimõiguste konventsiooni artikli 5 3. lõige : mõistlik aeg Euroopa Inimõiguste Kohtu praktikas ja Eesti õiguskorras : [bakalaureusetöö] / Toomas Ventsli ; Tartu Ülikool, õigusteaduskond ; juhendaja: Jaan Ginter

    Index Scriptorium Estoniae

    Ventsli, Toomas

    2003-01-01

    Vabaduse võtmise kohtulik kontroll, kinnipidamise mõistlikkuse hindamine, mõistlik aeg Eesti õigussüsteemis - vahi alla võtmist ja vahi all pidamise pikendamist reguleerivad õigusallikad, eelvangistuses viibitud aeg, vahi all pidamise pikendamine, kinnipidamise põhjendatuse hindamine

  7. Prokaryotic expression and purification of anti-AEG-1 single-chain variable antibody%抗 AEG-1单链可变区抗体的原核表达及纯化

    Institute of Scientific and Technical Information of China (English)

    路蔓; 刘昕阳; 龙敏; 王琛; 刘冲; 郜赵伟; 欧阳永日; 陈曦; 张惠中

    2015-01-01

    Objective To construct anti-astrocyte elevated gene-1(AEG-1)single-chain variable antibody (V23)prokaryotic ex-pression vector,and to conduct the protein purification and immunological activity detection.Methods The Primer5 software was applied to design the primers aiming at the gene sequence of the antibody anti-AEG-1 single-chain variable region for constructing the prokaryotic expression plasmid of PRsetC/V23.After the enzyme digestion by the restriction enzyme Pst1 and correct DNA se-quencing,the prokaryotic expression plasmid was led to E.coli BL21 ,the prokaryotic expression engineering strain containing the V23 gene was constructed.After the induction with IPTG,the interest protein was purified by the magnetic beads with the HIS tag,and the content of interest protein was determined by the SDS-PAGE electrophoresis.Western blot and ELISA were adopted to detect the immune activity of the nti-AEG-1 single-chain variable region antibody.Results For the constructed prokaryotic expres-sion plasmid PRsetC/V23,the single enzyme digestion and sequencing analysis displayed that the constructed V23 gene was com-pletely consistent to the designing sequences.After IPTG induction,SDS-PAGE electrophoresis showed an apparent protein band at 31×103 ,the Western blot detection showed a specific AEG-1 response band at 80 ×103 ,the ELISA test showed the positive re-sults.Conclusion The PRsetC/V23 prokaryotic expression plasmid and the V23 prokaryotic expression engineering strain are suc-cessfully constructed,this engineering strain can express anti-AEG-1 single-chain variable region antibody protein,and the protein has good immune activity.%目的:构建抗星形细胞上调基因1(AEG-1)单链可变区抗体(V23)的原核表达载体,并对表达蛋白进行纯化及免疫活性检测。方法应用 Primer5软件设计针对抗 AEG-1单链可变区抗体基因序列的引物,构建 PRsetC/V23原核表达质粒,经限制性内切酶 Pst1酶切以及 DNA

  8. An IgE epitope of Bet v 1 and fagales PR10 proteins as defined by a human monoclonal IgE

    DEFF Research Database (Denmark)

    Hecker, J.; Diethers, A.; Schulz, D.;

    2012-01-01

    BACKGROUND: Analyses of the molecular basis underlying allergenicity and allergen cross-reactivity, as well as improvement of allergy diagnostics and therapeutics, are hampered by the lack of human monoclonal IgE antibodies and knowledge about their epitopes. Here, we addressed the consecutive...... generation and epitope delineation of a human monoclonal IgE against the prototypic allergen Bet v 1. METHODS: Phage-display scFv hybrid libraries of allergic donor-derived VH epsilon and synthetic VL were established from 107 mononuclear cells. An obtained scFv was converted into human immunoglobulin...... formats including IgE. Using variants of Bet v 1, the epitope of the antibody was mapped and extrapolated to other PR10 proteins. RESULTS: The obtained antibodies exhibited pronounced reactivity with Bet v 1, but were not reactive with the homologous PR10 protein Mal d 1. The epitope as defined by the IgE...

  9. Particle tracking at 4 K: The Fast Annihilation Cryogenic Tracking (FACT) detector for the AEgIS antimatter gravity experiment

    Energy Technology Data Exchange (ETDEWEB)

    Storey, J., E-mail: james.storey@cern.ch [Albert Einstein Center for Fundamental Physics, Laboratory for High Energy Physics, University of Bern, 3012 Bern (Switzerland); Canali, C. [University of Zurich, Physics Institute, Winterthurerstrasse 190, 8057 Zurich (Switzerland); Aghion, S. [Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano (Italy); Istituto Nazionale di Fisica Nucleare, Sez. di Milano, Via Celoria 16, 20133 Milano (Italy); Ahlén, O. [European Organisation for Nuclear Research, Physics Department, 1211 Geneva 23 (Switzerland); Amsler, C.; Ariga, A.; Ariga, T. [Albert Einstein Center for Fundamental Physics, Laboratory for High Energy Physics, University of Bern, 3012 Bern (Switzerland); Belov, A.S. [Institute for Nuclear Research of the Russian Academy of Sciences, Moscow 117312 (Russian Federation); Bonomi, G. [University of Brescia, Department of Mechanical and Industrial Engineering, Via Branze 38, 25133 Brescia (Italy); Istituto Nazionale di Fisica Nucleare, Sez. di Pavia, Via Agostino Bassi 6, 27100 Pavia (Italy); Bräunig, P. [University of Heidelberg, Kirchhoff Institute for Physics, Im Neuenheimer Feld 227, 69120 Heidelberg (Germany); Bremer, J. [European Organisation for Nuclear Research, Physics Department, 1211 Geneva 23 (Switzerland); Brusa, R.S. [Dipartimento di Fisica, Università di Trento and INFN, Gruppo Collegato di Trento, Via Sommarive 14, 38050 Povo, Trento (Italy); Burghart, G. [European Organisation for Nuclear Research, Physics Department, 1211 Geneva 23 (Switzerland); Cabaret, L. [Laboratoire Aimé Cotton, CNRS, Université Paris Sud, ENS Cachan, Bâtiment 505, Campus d' Orsay, 91405 Orsay Cedex (France); Carante, M. [Istituto Nazionale di Fisica Nucleare, Sez. di Pavia, Via Agostino Bassi 6, 27100 Pavia (Italy); Caravita, R. [University of Milano, Department of Physics, Via Celoria 16, 20133 Milano (Italy); and others

    2013-12-21

    The AEgIS experiment is an international collaboration with the main goal of performing the first direct measurement of the Earth's gravitational acceleration on antimatter. Critical to the success of AEgIS is the production of cold antihydrogen (H{sup ¯}) atoms. The FACT detector is used to measure the production and temperature of the H{sup ¯} atoms and for establishing the formation of a H{sup ¯} beam. The operating requirements for this detector are very challenging: it must be able to identify each of the thousand or so annihilations in the 1 ms period of pulsed H{sup ¯} production, operate at 4 K inside a 1 T solenoidal field and not produce more than 10 W of heat. The FACT detector consists of two concentric cylindrical layers of 400 scintillator fibres with a 1 mm diameter and a 0.6 mm pitch. The scintillating fibres are coupled to clear fibres which transport the scintillation light to 800 silicon photomultipliers. Each silicon photomultiplier signal is connected to a linear amplifier and a fast discriminator, the outputs of which are sampled continuously by Field Programmable Gate Arrays (FPGAs). In the course of the developments for the FACT detector we have established the performance of scintillating fibres at 4 K by means of a cosmic-ray tracker operating in a liquid helium cryostat. The FACT detector was installed in the AEgIS apparatus in December 2012 and will be used to study the H{sup ¯} formation when the low energy antiproton physics programs resume at CERN in the Summer of 2014. This paper presents the design requirements and construction methods of the FACT detector and provides the first results of the detector commissioning.

  10. Particle tracking at 4K: The Fast Annihilation Cryogenic Tracking (FACT) detector for the AEgIS antimatter gravity experiment

    CERN Document Server

    Storey, J; Ahlén, O; Amsler, C; Ariga, A; Ariga, T; Belov, A.S; Bonomi, G; Bräunig, P; Bremer, J; Brusa, R.S; Burghart, G; Cabaret, L; Canali, C; Carante, M; Caravita, R; Castelli, F; Cerchiari, G; Cialdi, S; Comparat, D; Consolati, G; Dassa, L; Di Domizio, S; Di Noto, L; Doser, M; Dudarev, A; Ereditato, A; Ferragut, R; Fontana, A; Genova, P; Giammarchi, M; Gligorova, A; Gninenko, S.N; Haider, S; Hogan, S.D; Huse, T; Jordan, E; Jørgensen, L.V; Kaltenbacher, T; Kawada, J; Kellerbauer, A; Kimura, M; Knecht, A; Krasnický, D; Lagomarsino, V; Magnani, A; Mariazzi, S; Matveev, V.A; Merkt, F; Moia, F; Nebbia, G; Nédélec, P; Oberthaler, M.K; Pacifico, N; Petrácek, V; Pistillo, C; Prelz, F; Prevedelli, M; Regenfus, C; Riccardi, C; Røhne, O; Rotondi, A; Sandaker, H; Scampoli, P; Spacek, M; Subieta Vasquez, M.A; Testera, G; Trezzi, D; Vaccarone, R; Zavatarelli, S

    2013-01-01

    The AEgIS experiment is an international collaboration with the main goal of performing the fi rst direct measurement of the Earth ' s gravitational acceleration on antimatter. Critical to the success of AEgIS is the production of cold antihydrogen ( H) atoms. The FACT detector is used to measure the production and temperature of the H atoms and for establishing the formation of a H beam. The operating requirements for this detector are very challenging: it must be able to identify each of the thousand or so annihilations in the 1 ms period of pulsed H production, operate at 4 K inside a 1 T solenoidal fi eld and not produce more than 10 W of heat. The FACT detector consists of two concentric cylindrical layers of 400 scintillator fi bres with a 1 mm diameter and a 0.6 mm pitch. The scintillating fi bres are coupled to clear fi bres which transport the scintillation light to 800 silicon photomultipliers. Each silicon photomultiplier signal is connected to a linear ampli fi er and a fast discriminator, the out...

  11. [Kari Tarkiainen, Ülle Tarkiainen. Provinsen bortom havet : Estlands svenska historia 1561-1710; Kari Tarkiainen, Ülle Tarkiainen. Meretagune maa : Rootsi aeg Eestis 1561-1710] / Pärtel Piirimäe

    Index Scriptorium Estoniae

    Piirimäe, Pärtel, 1972-

    2015-01-01

    Arvustus: Tarkiainen Kari, Tarkiainen Ülle. Provinsen bortom havet : Estlands svenska historia 1561-1710 Verlag Atlantis. Stockholm 2013; Tarkiainen, Kari, Tarkiainen, Ülle. Meretagune maa : Rootsi aeg Eestis 1561-1710. verlag Varrak Tallinn 2014

  12. ANS complex of St John’s wort PR-10 protein with 28 copies in the asymmetric unit: a fiendish combination of pseudosymmetry with tetartohedral twinning

    Energy Technology Data Exchange (ETDEWEB)

    Sliwiak, Joanna [Polish Academy of Sciences, Poznan (Poland); Dauter, Zbigniew [National Cancer Institute, Argonne National Laboratory, Argonne, IL 60439 (United States); Kowiel, Marcin [Poznan University of Medical Sciences, Poznan (Poland); McCoy, Airlie J.; Read, Randy J. [University of Cambridge, Cambridge CB2 0XY (United Kingdom); Jaskolski, Mariusz, E-mail: mariuszj@amu.edu.pl [Polish Academy of Sciences, Poznan (Poland); A. Mickiewicz University, Poznan (Poland)

    2015-04-01

    Hyp-1, a pathogenesis-related class 10 (PR-10) protein from H. perforatum, was crystallized in complex with the fluorescent probe 8-anilino-1-naphthalene sulfonate (ANS). The asymmetric unit of the tetartohedrally twinned crystal contains 28 copies of the protein arranged in columns with noncrystallographic sevenfold translational symmetry and with additional pseudotetragonal rotational NCS. Hyp-1, a pathogenesis-related class 10 (PR-10) protein from St John’s wort (Hypericum perforatum), was crystallized in complex with the fluorescent probe 8-anilino-1-naphthalene sulfonate (ANS). The highly pseudosymmetric crystal has 28 unique protein molecules arranged in columns with sevenfold translational noncrystallographic symmetry (tNCS) along c and modulated X-ray diffraction with intensity crests at l = 7n and l = 7n ± 3. The translational NCS is combined with pseudotetragonal rotational NCS. The crystal was a perfect tetartohedral twin, although detection of twinning was severely hindered by the pseudosymmetry. The structure determined at 2.4 Å resolution reveals that the Hyp-1 molecules (packed as β-sheet dimers) have three novel ligand-binding sites (two internal and one in a surface pocket), which was confirmed by solution studies. In addition to 60 Hyp-1-docked ligands, there are 29 interstitial ANS molecules distributed in a pattern that violates the arrangement of the protein molecules and is likely to be the generator of the structural modulation. In particular, whenever the stacked Hyp-1 molecules are found closer together there is an ANS molecule bridging them.

  13. IgE recognition patterns of profilin, PR-10, and tropomyosin panallergens tested in 3,113 allergic patients by allergen microarray-based technology.

    Directory of Open Access Journals (Sweden)

    Enrico Scala

    Full Text Available BACKGROUND: IgE recognition of panallergens having highly conserved sequence regions, structure, and function and shared by inhalant and food allergen sources is often observed. METHODS: We evaluated the IgE recognition profile of profilins (Bet v 2, Cyn d 12, Hel a 2, Hev b 8, Mer a 1, Ole e 2, Par j 3, Phl p 12, Pho d 2, PR-10 proteins (Aln g 1, Api g 1, Bet v 1.0101, Bet v 1.0401, Cor a 1, Dau c 1 and Mal d 1.0108 and tropomyosins (Ani s 3, Der p 10, Hel as 1, Pen i 1, Pen m 1, Per a 7 using the Immuno-Solid phase Allergen Chip (ISAC microarray system. The three panallergen groups were well represented among the allergenic molecules immobilized on the ISAC. Moreover, they are distributed in several taxonomical allergenic sources, either close or distant, and have a route of exposure being either inhalation or ingestion. RESULTS: 3,113 individuals (49.9% female were selected on the basis of their reactivity to profilins, PR-10 or tropomyosins. 1,521 (48.8% patients were reactive to profilins (77.6% Mer a 1 IgE(+, 1,420 (45.6% to PR-10 (92.5% Bet v 1 IgE(+ and 632 (20.3% to tropomyosins (68% Der p 10 IgE(+. A significant direct relationship between different representative molecules within each group of panallergens was found. 2,688 patients (86.4% recognized only one out of the three distinct groups of molecules as confirmed also by hierarchical clustering analysis. CONCLUSIONS: Unless exposed to most of the allergens in the same or related allergenic sources, a preferential IgE response to distinct panallergens has been recorded. Allergen microarray IgE testing increases our knowledge of the IgE immune response and related epidemiological features within and between homologous molecules better describing the patients' immunological phenotypes.

  14. 漾濞大泡核桃病程相关蛋白10基因JsPR10-1的克隆与表达分析

    Institute of Scientific and Technical Information of China (English)

    何华; 陈朝银; 韩青; 张南南; 葛锋; 刘迪秋

    2014-01-01

    病程相关蛋白(pathogenesisrelated protein, PR) 10的激活与积累在植物抗逆境胁迫中有非常重要的作用。根据漾濞大泡核桃(Juglans sigillata)编码PR10的EST(expressed sequence tag)序列设计引物,利用快速扩增cDNA末端技术,克隆得到PR10基因的全长cDNA序列,并命名为JsPR10-1。JsPR10-1全长cDNA为776 bp,含有483 bp的开放阅读框、74 bp 5′-非编码区以及219 bp 3′-非编码区,编码含有160个氨基酸的蛋白质。全长基因序列中含有1个124 bp的内含子。JsPR10-1编码的蛋白质与栎树(Quercus suber)、欧洲山毛榉(Fagus sylvatica)以及欧洲板栗(Castanea sativa)的PR10相似性较高,并且在PR10的系统进化树中与双子叶植物聚为一支。qRT-PCR分析结果表明,植物信号分子水杨酸、茉莉酸、乙烯以及过氧化氢处理均可诱导JsPR10-1表达。在接种胶孢炭疽菌(Colletotrichum gloeosporioides)后,JsPR10-1的表达量迅速上升并在接种8 h时达到最大值,表明JsPR10-1参与漾濞大泡核桃对胶孢炭疽菌的防卫反应。本研究为揭示漾濞大泡核桃抗性机制奠定了理论依据。

  15. Muusika : Juubelikontserdid "ERSO 75". Tüür uuel CD-l. Muusikakonverentsid Tallinnas. Highlightsi festivalist "Eduard Tubin ja tema aeg". Hermanni päev / Vardo Rumessen

    Index Scriptorium Estoniae

    Rumessen, Vardo, 1942-2015

    2001-01-01

    ERSO saab detsembris 75. aastaseks ja sel puhul on kavas kontserdid nii Tartus kui Tallinnas. Ansambel Piano Circus on välja antud uue CD, millele annab nime avateos ئ Erkki-Sven Tüüri "Transmission". Eesti Muusikateaduse Selts korraldab 3.XII EMA-s sümpoosioni teemal Beethoveni muusika. 1. ja 2. XII EMA-s toimub konverents "Interpretatsioonipedagoogika probleeme II". Põhjamaade muusikaajakirja Highlights XI numbris ilmus ülevaade rahvusvahelisest muusikafestivalist "Eduard Tubin ja tema aeg". Eesti teatri- ja muusikamuuseumis toimub helilooja, ajakirjaniku, muusika- ja keeleteadlase, dr. Karl August Hermanni päev

  16. Exposure to cadmium chloride influences astrocyte-elevated gene-1 (AEG-1) expression in MDA-MB231 human breast cancer cells.

    Science.gov (United States)

    Luparello, Claudio; Longo, Alessandra; Vetrano, Marco

    2012-01-01

    It is known that cadmium (Cd) is able to regulate gene expression, drastically affecting the pattern of transcriptional activity and intracellular signalization in normal and pathological human cells. We have already shown that Cd exerts a cytotoxic effect on neoplastic MDA-MB231 cells from the human breast, which is characterized by the onset of a "non-classical" apoptotic kind of death, impairment of mitochondrial activity and drastic changes in gene expression pattern. In the present study, employing a combination of conventional and differential display-PCR techniques, immunocytochemical, ELISA and Western analyses, we extended the knowledge on the transcriptional modulation exerted by the metal demonstrating that in MDA-MB231 cells 5 μM CdCl(2) treatment for 96 h selectively down-regulates astrocyte-elevated gene-1 (AEG-1) and reduces the accumulation of its protein product which appears to be associated with the internal cytomembranes and also present in the nucleoplasm. In addition, due to the acknowledged role of AEG-1 in the intranuclear shuttling of NF-κB p65 subunit, we also showed that CdCl(2) treatment determines the decrease of p65 amount in nuclear extracts and the down-regulation of the NF-κB downstream genes c-fos and c-jun, thus providing a new contribution to the comprehension of the intracellular molecular mechanisms implicated in Cd-breast cancer cell interactions.

  17. High-Content Functional Screening of AEG-1 and AKR1C2 for the Promotion of Metastasis in Liver Cancer.

    Science.gov (United States)

    Li, Cong; Wu, Xia; Zhang, Wei; Li, Jia; Liu, Huawei; Hao, Ming; Wang, Junsong; Zhang, Honghai; Yang, Gengxia; Hao, Meijun; Sheng, Shoupeng; Sun, Yu; Long, Jiang; Li, Juan; Zhuang, Fengfeng; Hu, Caixia; Li, Li; Zheng, Jiasheng

    2016-01-01

    Liver cancer is one of the most lethal cancer types in humans, but our understanding of the molecular mechanisms underlying this process remains insufficient. Here, we conducted high-content screening of the potential genes involved in liver cancer metastasis, which we selected from the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database, based on the SAMcell method and RNA interference technology. We identified two powerful genes in the liver cancer metastasis process, AEG-1 and AKR1C2, both of which proved to be positive regulators in promoting metastasis in liver cancer. Further clinical results verified their roles in liver cancer. In summary, these findings could provide new insight into the liver cancer mechanism and potentially therapeutic novel targets for liver cancer therapies in the future.

  18. Positronium in the AEgIS experiment: study on its emission from nanochanneled samples and design of a new apparatus for Rydberg excitations

    CERN Document Server

    Di Noto, Lea

    This experimental thesis has been done in the framework of AEgIS (Antimatter Experiment: Gravity, Interferometry, Spectroscopy), an experiment installed at CERN, whose primary goal is the measurement of the Earth's gravitational acceleration on anti-hydrogen. The antiatoms will be produced by the charge exchange reaction, where a cloud of Ps in Rydberg states interacts with cooled trapped antiprotons. Since the charge exchange cross section depends on Ps velocity and quantum number, the velocity distribution of Ps emitted by a positron-positronium converter as well as its excitation in Rydberg states have to be studied and optimized. In this thesis Ps cooling and emission into vacuum from nanochannelled silicon targets was studied by performing Time of Flight measurements with a dedicated apparatus conceived to receive the slow positron beam as produced at the Trento laboratory or at the NEPOMUC facility at Munich. Measurements were done by varying the positron implantation energy, the sample temperature and ...

  19. Aeg aias / Jaan Mettik

    Index Scriptorium Estoniae

    Mettik, Jaan

    2007-01-01

    Päikesekellade ajaloost, tüüpidest, Santiago Calatrava kavandatud jalakäijate sillast-päikesekellast Californias, Eesti päikesekelladest Kadrioru pargis, Haapsalu rannapromenaadil (Roman Haavamägi) ja Saue tammepargis (Hanno Grossschmidt, Tomoni Hayashi). Kuukelladest, Karl Linne lillekellast, libalillekelladest. Juhised päikesekella tegemiseks. Lk. 60-61 "Ajanäitajaid lillekellale"

  20. Faehlmanni aeg / Ea Jansen

    Index Scriptorium Estoniae

    Jansen, Ea, 1921-2005

    2004-01-01

    Faehlmanni ja tema kaasaegsete - parun Nolckeni, läti mõisnik Hamilkahr von Fölkersahmi, Tartu ülikooli rektori Carl Christian Ullmanni, Karl von Bruiningki, Karl Ludvig Blumi, Marie Bruiningki jt. ajastukonfliktide käsitlusi ja hoiakuid suhtumises eesti talurahvasse

  1. Moodne aeg : Moeuudised

    Index Scriptorium Estoniae

    2000-01-01

    Moes on puhvseelik, mis moekriitik Amanda Harlech'i arvates teeb naise keha inetuks. Londonis elava prantslanna Emma Cassid'i cool'id ridikülid. Sian Evansi toidukäruga sõrmused. Graafik James Jarvise disainitud Briti firma Silas'i Evil Martini nimeline kummilelu ning tema sõber kummikass Bubba the Car.

  2. 漾濞大泡核桃病程相关蛋白10基因JsPR10-1的克隆与表达分析%Cloning and Expression Analysis of a Pathogenesis-related Protein 10 Gene from Juglans sigillata

    Institute of Scientific and Technical Information of China (English)

    何华; 陈朝银; 韩青; 张南南; 葛锋; 刘迪秋

    2014-01-01

    The activation and accumulation of pathogenesis-related protein (PR) 10 play predominant roles in the defense response against pathogens.Based on a Juglans sigillata expressed sequence tag (EST) encoding PR10,gene-specific primers were designed and used to amplify the full-length cDNA of a novel PR10 gene by rapid amplification of cDNA ends (RACE).This gene was named as JsPR10-1.JsPR10-1 was 776 bp in length with an open reading frame (ORF) of 483 bp,a 5'-untranslated region (UTR) of 74 bp,and a 3'-UTR of 219 bp,and the ORF encoded a protein with 160 amino acid residues.There was an intron of 124 bp in the genomic sequence of JsPR10-1.Homology analysis indicated that JsPR10-1 was homologous with PR10s from Quercus suber,Fagus sylvatica and Castanea sativa;moreover,JsPR10-1 clustered together with the PR10s from dicots in the phylogenetic tree.qRT-PCR analysis showed that the expression levels of JsPR10-1 were induced by four different plant signaling molecules,including salicylic acid,jasmonic acid,ethylene,and H2O2.In addition,after inoculation with Colletotrichum gloeosporioides,JsPR10-1 was sharply up-regulated with the highest expression level at 8 h.The JsPR10-1 gene was involved in the defense response against C.gloeosporioides.This experiment lays a theoretical foundation for revealing the mechanism of resistance in J.sigillata.%病程相关蛋白(pathogenesis-related protein,PR) 10的激活与积累在植物抗逆境胁迫中有非常重要的作用.根据漾濞大泡核桃(Juglans sigillata)编码PR10的EST (expressed sequence tag)序列设计引物,利用快速扩增cDNA末端技术,克隆得到PR10基因的全长cDNA序列,并命名为JsPR10-1.JsPR10-1全长cDNA为776 bp,含有483 bp的开放阅读框、74 bp 5'-非编码区以及219 bp 3'-非编码区,编码含有160个氨基酸的蛋白质.全长基因序列中含有1个124 bp的内含子.JsPR10-1编码的蛋白质与栎树(Quercus suber)、欧洲山毛榉(Fagus sylvatica

  3. AEG评审在型号合格审定中的研究与应用%Research and Application of AEG Evaluation on Type Certification

    Institute of Scientific and Technical Information of China (English)

    段本印

    2015-01-01

    概述了申请人的航空器评审工作,并简要对比分析了运行符合性清单、型别等级和训练要求、MMEL、MRBR、OCAI等11个AEG工作评审项目。同时通过对比分析航空器评审组(简称AEG)评审与型号合格审定之间的区别和联系,为申请人顺利开展AEG工作提出4条建议。%The applicant’ s work of aircraft evaluation is introduced in this paper, and 11 aircraft evaluation items are listed, including operation compliance checklist, type rating and qualification specification, MMEL, MRBR, OCAI, etc. The difference and relation between aircraft evaluation and type certification are contrasted and ana-lyzed at the same time ,and 4 suggestions are provided to the applicant in order to develop aircraft evaluation.

  4. Sequential FDG-PET and induction chemotherapy in locally advanced adenocarcinoma of the Oesophago-gastric junction (AEG: The Heidelberg Imaging program in Cancer of the oesophago-gastric junction during Neoadjuvant treatment: HICON trial

    Directory of Open Access Journals (Sweden)

    Weichert Wilko

    2011-06-01

    Full Text Available Abstract Background 18-Fluorodeoxyglucose-PET (18F-FDG-PET can be used for early response assessment in patients with locally advanced adenocarcinomas of the oesophagogastric junction (AEG undergoing neoadjuvant chemotherapy. It has been recently shown in the MUNICON trials that response-guided treatment algorithms based on early changes of the FDG tumor uptake detected by PET are feasible and that they can be implemented into clinical practice. Only 40%-50% of the patients respond metabolically to therapy. As metabolic non-response is known to be associated with a dismal prognosis, metabolic non-responders are increasingly treated with alternative neoadjuvant chemotherapies or chemoradiation in order to improve their clinical outcome. We plan to investigate whether PET can be used as response assessment during radiochemotherapy given as salvage treatment in early metabolic non-responders to standard chemotherapy. Methods/Design The HICON trial is a prospective, non-randomized, explorative imaging study evaluating the value of PET as a predictor of histopathological response in metabolic non-responders. Patients with resectable AEG type I and II according to Siewerts classification, staged cT3/4 and/or cN+ and cM0 by endoscopic ultrasound, spiral CT or MRI and FDG-PET are eligible. Tumors must be potentially R0 resectable and must have a sufficient FDG-baseline uptake. Only metabolic non-responders, showing a 18FDG-PET scans will be performed before ( = Baseline and after 14 days of standard neoadjuvant therapy as well as after the first cycle of salvage docetaxel/cisplatin chemotherapy (PET 1 and at the end of radiochemotherapy (PET2. Tracer uptake will be assessed semiquantitatively using standardized uptake values (SUV. The percentage difference ΔSUV = 100 (SUVBaseline - SUV PET1/SUVBaseline will be calculated and assessed as an early predictor of histopathological response. In a secondary analysis, the association between the difference

  5. Otsustamise aeg meditsiinis / Eiki Nestor

    Index Scriptorium Estoniae

    Nestor, Eiki, 1953-

    2005-01-01

    Ilmunud ka: Vali Uudised 10. aug., lk. 2, Põhjarannik 10. aug., lk. 2, Severnoje Poberezhje 10. aug., lk. 2,Lõunaleht 11. aug., lk. 2, Koit 11. aug., lk.6, Meie Maa 11. aug. lk. 2, Hiiu Leht 12. aug. lk. 2, Valgamaalane 13. aug, lk.2, Nädaline 13. august lk. 4, Järva Teataja 16. aug, lk.2, Vooremaa 16. aug. lk. 2, Sakala 17. aug. lk. 2, Linnaleht : Tartu 26. aug. lk. A8. Kulutustest tervishoius ning kuidas neid vähendada

  6. Animeeritud fantaasiate aeg / Tiit Tuumalu

    Index Scriptorium Estoniae

    Tuumalu, Tiit, 1971-

    2006-01-01

    23. nov. algab PÖFFi raames toimuv animafilmifestifal "Animated Dreams", kus üks esimeste hulgas näidatavaid filme on inglase Phil Mulloy "Perekond Christie". Keskne on šveitsi klassiku Georges Schwizgebeli retrospektiiv, on eesti uut animatsiooni, muusikavideosid jne

  7. Aeg niite liimida / Piret Bristol

    Index Scriptorium Estoniae

    Bristol, Piret, 1968-

    2002-01-01

    Arvustus: Hellat, Henn-Kaarel. Niidiliimija. Tallinn : Faatum, 2002. Vastukaja: Hellat, Henn-Kaarel. Selgitus // Sirp (2002) 13. sept., lk. 5. H.-K. Hellat väidab, et ta ei ole müstifikatsiooni "Helilooja Müller" (1997) autor Alex Barber

  8. Viimane aeg tegutseda / Victoria Punga

    Index Scriptorium Estoniae

    Punga, Victoria, 1977-

    2010-01-01

    Eesti NATO ühingu juhataja ÜRO resolutsioonist nr.1325 - naise rollist rahu, stabiilsuse ja julgeoleku tagamisel. Eesti on üks esimesi, kes on loomas oma konkreetset tegevuskava naiste olukorra parandamiseks maailma relvakonfliktides

  9. Nõukogude aeg naaseb piimapakis / Askur Alas

    Index Scriptorium Estoniae

    Alas, Askur, 1973-

    2004-01-01

    Tallinna Piimatööstuse kaubamärgi Turbo-lehm kolmnurkse kartongpakendi kujunduse tegi reklaamifirma DDB Eesti AS, kellega koos valmis ka Turbo-lehma tegelaskuju. Lehma joonistas kunstnik Raivo Tihhonov. Reklaamifirmade kommentaarid

  10. On jõulujuttude aeg / Krista Kumberg

    Index Scriptorium Estoniae

    Kumberg, Krista, 1959-

    2007-01-01

    Arvustus: Minu jõulujutt / [koostajad Jane Liiv, Terje Puistaja, Tiia Toomet]. Tartu : Eesti Rahva Muuseum, 2007 ; Soasepp, Tiia. PPP, ehk, Pesulõksupäkapikkude projekt. Tallinn : Koolibri, 2007 ; Toompere, Harriet. Väikese põhjapõdra uued lood / illustreerinud Anu Kalm. [Tallinn] : Varrak, 2007

  11. Aeg taas Hiina investeerida / Romet Kreek

    Index Scriptorium Estoniae

    Kreek, Romet, 1972-

    2008-01-01

    Jim Rogers leiab, et Hiina ettevõtete aktsiad on tasemel, kust tasub neid jälle ostma hakata. Diagramm: USA aktsiaturul kaubeldud Hiina indeksaktsia FXI on asunud üles rühkima. Vt. samas: USA börsil on Hiina aktsiaid Eesti investoritel lihtne osta-müüa; Taust

  12. Aeg vaadata taas Citigroupi / Peeter Teder

    Index Scriptorium Estoniae

    Teder, Peeter

    2006-01-01

    Vaatamata USA ühe suurima panga Citigroup kasumi kasvule on ettevõttel siiski pärast Enroni ja WorldComi skandaale raskusi investorite leidmisega. Diagramm: Citigroupi aktsia on vaid paar korda käinud 50 dollari tasemest kõrgemal. Vt. samas: Kasvuvõimega pank

  13. Antimatter annihilation detection with AEgIS

    CERN Document Server

    Gligorova, Angela

    2015-01-01

    AE ̄ gIS (Antimatter Experiment: Gravity, Interferometry, Spectroscopy) is an antimatter exper- iment based at CERN, whose primary goal is to carry out the first direct measurement of the Earth’s gravitational acceleration on antimatter. A precise measurement of antimatter gravity would be the first precision test of the Weak Equivalence Principle for antimatter. The principle of the experiment is based on the formation of antihydrogen through a charge exchange reaction between laser excited (Rydberg) positronium and ultra-cold antiprotons. The antihydrogen atoms will be accelerated by an inhomogeneous electric field (Stark acceleration) to form a pulsed cold beam. The free fall of the antihydrogen due to Earth’s gravity will be measured using a moiré de- flectometer and a hybrid position detector. This detector is foreseen to consist of an active silicon part, where the annihilation of antihydrogen takes place, followed by an emulsion part coupled to a fiber time-of-flight detector. This overview prese...

  14. Uus aeg, uus tehing / Kristjan Otsmann

    Index Scriptorium Estoniae

    Otsmann, Kristjan, 1971-

    2009-01-01

    Autor tutvustab ärikirjaniku Seth Godini soovitusi majanduslanguse edukaks üleelamiseks: muuta end asendamatuks, usaldusväärseks ning oma ala asjatundjaks, kasulikum on olla väike kui suur ettevõtja ning eesmärgid tuleb siduda konkreetsete tegevustega

  15. Aeg panustada nafta hinna langusele / Tarvo Vaarmets

    Index Scriptorium Estoniae

    Vaarmets, Tarvo

    2008-01-01

    Autor analüüsib maailma naftatootmist ning leiab, et vähenev naftanõudlus võib viia nafta hinna langusele. Vt. samas: Kuidas nafta hinna langusest kasu lõigata?; Tabel: Naftaturg; Võrdlusandmed

  16. Kungla rahva kuldne aeg / Karin Paulus

    Index Scriptorium Estoniae

    Paulus, Karin, 1975-

    2016-01-01

    1970ndal aastal Lomonossovi tänavale (praegune Gonsiori tänav) ehitatud Kungla hotellist. Arhitektid Ilmar Puumets, Herbert Rüütlane; sisearhitektid Valter Pormeister, Ingrid Pormeister, Maia Laul. Samale kohale ehitati hiljem 13-korruseline Hilton hotell

  17. Minister Looduse aeg on otsas / Toivo Tootsen

    Index Scriptorium Estoniae

    Tootsen, Toivo, 1943-

    2001-01-01

    Ilmunud ka: Hiiumaa, 31. aug. 2001, lk. 6; Meie Maa, 31. aug. 2001, lk. 2; Kesknädal, 6. sept. 2001, lk. 4; Nädaline, 4. sept. 2001, lk. 5; Sakala, 4. sept. 2001, lk. 2; Nädaline, 4. sept. 2001, lk. 5; Vooremaa, 4. sept. 2001, lk. 2; Virumaa Teataja, 5. sept. 2001, lk. 7. Siseminister peaks tagasi astuma. Autor: Keskerakond. Parlamendisaadik

  18. Veelgi kehvemate kasumite aeg / James C. Cooper

    Index Scriptorium Estoniae

    Cooper, James C.

    2008-01-01

    Finantssektorist väljaspool tegutsevate ettevõtete kasumid on hämmastavalt stabiilsed püsinud, kuid laenukriis, tõusvad toormaterjali hinnad ja välisriikide majanduste jahtumine ei jäta oma mõju avaldamata ka Ameerikale

  19. Täidetud aeg / Urmas Petti

    Index Scriptorium Estoniae

    Petti, Urmas, 1965-

    2013-01-01

    Usust, lootusest ja armastusest lihavõttepühadele eelneval Suurel nädalal; autor kommenteerib ka Kadri Tüüri, Haruki Murakami (romaanist "Kafka mererannas") ja Rein Raua (romaanist "Vend") mõtteid

  20. 经左胸腹全胸腔镜食管胃交界区腺癌外科治疗(附17例报告)%The treatment of adenocarcinoma of the esophagogastric junction (AEG) by endoscopic radical oesophagectomy (report of 17 cases)

    Institute of Scientific and Technical Information of China (English)

    宿学家; 张志勇; 朱斌; 谭鑫; 范波

    2014-01-01

    目的:研究探讨胸腔镜下食管胃交界部腺癌(adenocarcinoma of the esophagogastric junction AEG)的手术体位、入路和手术方法的可行性及安全性。方法2011年11月至2014年03月对17例A E G行右侧卧位经左胸腹完全腔镜下根治术:右侧卧位经左胸行腔镜下下段食管的游离及清扫纵隔淋巴结,开膈肌,第七肋间肋弓下、腹直肌外缘做5cm长切口,腔镜辅助下游离贲门、胃及清扫胃左动脉、网膜淋巴结,普通消化道吻合器行食管胃吻合。结果无中转开胸。总手术时间:110-190m i n,平均146m i n。术中无大出血,总出血量30-150m l,平均110m l。共清扫纵隔淋巴结104枚,平均每例6.1枚;清扫腹腔淋巴结133枚,平均每例7.8例。术后住院9-14d,平均11d。住院期间病人无死亡。术后并发症:肺部感染2例,无吻合口漏。结论右侧卧位经左胸腹全腔镜下AEG的外科治疗是可行安全的,近期效果良好,并发症少,达到左侧开胸手术效果。但其长期疗效需要进一步研究、随访。%Objective To study the feasibility and safety of thoracoscopic surgery posturals and methods of the adenocarcinoma of the esophagogastric junction(AEG).Methods A total of 17 patients with AEG were operated with the right lateral endoscopic radical oesophagectomy from November 2011 to March 2014 : freeing the lower esophagus and clean mediastinal lymph nodes using thoracoscopy under the right side of the supine line, then opening the diaphragm and cuting 5cm long incision under the left seventh rib and the outer rectus abdominis, next by endoscopic-assisting freeing cardia, stomach and sweeping left gastric artery and omental lymph nodes, last esophagogastrostomy using a common gastrointestinal stapling. Results No transit thoracotomy. The total operation time :110-190min, average 146min. No massive hemorrhage, bleeding volume 30-150ml, average 110ml. Sweeping a total of 104

  1. ESI-PR10, Vega Alta, Puerto Rico 2000 (Environmental Sensitivity Index Map)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — Environmental Sensitivity Index (ESI) maps are an integral component in oil-spill contingency planning and assessment. They serve as a source of information in the...

  2. Aeg ei peatu, eestlane ei kao / Paul-Eerik Rummo

    Index Scriptorium Estoniae

    Rummo, Paul-Eerik, 1942-

    2005-01-01

    Rahvastiku vähenemine ja vananemine ohustab Eesti majanduslikku, sotsiaalset ja kultuurilist jätkusuutlikkust. Rahvastikuminister selgitab, mida riik on teinud nende ohtude tõrjumiseks ja mida kavatseb edasi teha

  3. Peaminister Juhan Partsil on viimane aeg sisekaemuseks / Ivari Padar

    Index Scriptorium Estoniae

    Padar, Ivari, 1965-

    2004-01-01

    Ilmunud ka: Severnoje Poberezhje, 14. sept. 2004, lk. 2; Pärnu Postimees, 15. sept. 2004, lk. 15; Valgamaalane, 16. sept. 2004, lk. 2; Koit, 16. sept. 2004, lk. 6; Võrumaa Teataja, 16. sept. 2004, lk. 2; Hiiu Leht, 17. sept. 2004, lk. 2; Harjumaa, 17. sept. 2004, lk. 2; Vali Uudised, 17. sept. 2004, lk. 2; Sakala, 17. sept. 2004, lk. 2; Türi Rahvaleht, 17. sept. 2004, lk. 4; Lääne Elu, 18. sept. 2004, lk. 2. Autor arutleb valitsuse ja peaministri tegevuse üle ning leiab, et Juhan Partsile käib peaministri töö üle jõu

  4. Kuhu kaob õpetaja aeg? / Heikki Silvet, Katrin Raidma

    Index Scriptorium Estoniae

    Silvet, Heikki, 1942-

    2012-01-01

    Küsimusele vastasid Heikki Silvet, Tallinna 32. keskkooli inglise keele, maailmavaateõpetuse ja vanakreeka keele õpetaja ja Katrin Raidma Tartu Karlova gümnaasiumi eesti keele ja kirjanduse õpetaja

  5. Hull aeg nõuab segaseid inimesi? / Margit Tõnson

    Index Scriptorium Estoniae

    Tõnson, Margit, 1978-

    2011-01-01

    Režissöör Shinya Tsikamoto film "Kotoko" (Jaapan, 2011), Urszula Antoniaki "Kood: sinine" (Taani-Hollandi 2011), Lisa Aschani "Ahviplikad" (Rootsi 2011), Oliver Hermanuse "Puhas ilu" (Lõuna-Aafrika, 2011) ja Andrei Zvjagintsevi "Jelena" (Venemaa, 2011) Pimedate Ööde Filmifestivalil

  6. Aeg parandada pearahasüsteemi / Tõnis Lukas

    Index Scriptorium Estoniae

    Lukas, Tõnis, 1962-

    2002-01-01

    Ilmunud ka: Virumaa Teataja 22. august lk. 7, Koit 22. august lk. 6, Põhjarannik, Severnoje Poberezhje, Meie Maa 23. august lk. 2;2, Lääne-Harju Ekspress 24. august lk. 4, Tartu : Postimees 28. august lk. 2, Nädaline 27. august lk. 4, Vooremaa 27.august lk. 8, Valgamaalane 29. august lk. 2, Pärnu Postimees 30. august lk. 10. Endine haridusminister leiab, et väikekoolidele tuleks tagada vähemalt 20% baasfinantseerimine, mis ei sõltu iga õppeaastaga kohe õpilaste arvu kahanemisest. Autor: Isamaaliit. Parlamendisaadik

  7. Repsil on aeg hakata haridusega tegelema / Piret Pert

    Index Scriptorium Estoniae

    Pert, Piret

    2006-01-01

    Sotsiaaldemokraatide hinnangul ei valda haridus- ja teadusminister Mailis Reps hariduseelnõude sisu, keeldub arutamast kõiki opositsiooni eelnõusid ega ilmu Riigikogu kultuurikomisjoni eelnõude arutamisele

  8. On aeg, mil vajame enam leiba kui lilli / Ants Juske

    Index Scriptorium Estoniae

    Juske, Ants, 1956-

    2009-01-01

    Marge Monko isikunäitus "Leib ja lilled" Tallinnas Draakoni Galeriis 21. märtsini. Eksponeeritud fotod ja video "Nora õed". Kunstnik on majanduses ja tööhõives asetleidvaid muutusi uurides aluseks võtnud Narva Kreenholmi Manufaktuuri näited

  9. EVPde aeg saab otsa / Uku Hänni

    Index Scriptorium Estoniae

    Hänni, Uku, 1943-

    2006-01-01

    Erastamisväärtpaberite kehtivusaeg saab käesoleva aastaga läbi. Sama ka Vooremaa 25. nov. 2006, lk. 4 ; Vooremaa : Palamuse Valla Teataja 25. nov. 2006, lk. 3 ; Kuulutaja 24. nov. 2006, lk. 4 ; Harjumaa 24. nov. 2006, lk. 2 ; Võrumaa Teataja 23. nov. 2006, lk. 2 ; Vali Uudised 29. nov. 2006, lk. 4 ; Vooremaa : Jõgeva Valla Teataja 2. Dets. 2006, lk. 3 ; Koit 2. Dets. 2006, lk. 6 ; Pärnu Postimees 7. Dets. 2006, lk. 15 ; Sakala 28. Dets. 2006, lk. 2

  10. Jaapanil aeg ennast üles ehitada / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2011-01-01

    Tsunami hävitas Jaapanis rannikualadel kaitserajatised, nüüd on selgunud, et kogu rannik tuleks tsunamikindlaks ehitada. Ülesehituseks oleks vaja uusi rahakanaleid avada, samas pole riik veel finantskrahhist toibunud. Tseesiumisisaldusest mullas, kalades

  11. Magistritiitli kui teaduskraadi aeg saab ümber / Sandra Maasalu

    Index Scriptorium Estoniae

    Maasalu, Sandra

    2009-01-01

    Üleminek Bologna süsteemile kõrghariduses suleb 4+2 magistriõppekavad. Tallinna Ülikooli õppeosakonna juhataja Imbi Teiteri sõnul oli neil viimane võimalus teadusmagistritööd kaitsta tänavu 1. septembril. Samal kuupäeval sulges vanad õppekavad ka Tallinna Tehnikaülikool. Tartu Ülikoolis on viimaseks kaitsmiskuupäevaks 31. august ja Eesti Maaülikoolil 2011. aasta lõpp

  12. Kahuriliha aeg on möödas / Tarmo Leinatamm

    Index Scriptorium Estoniae

    Leinatamm, Tarmo, 1957-2014

    2005-01-01

    Ilmunud ka: Türi Rahvaleht 18. nov., lk. 4, Vali Uudised 18. nov., lk. 2, Sakala 18. nov., lk. 2, Meie Maa 18. nov., lk. 2, Põhjarannik 18. nov., lk. 2, Severnoje Poberezhje 18. nov. lk. 2, Valgamaalane 19. nov., lk. 2, Lääne Elu 19. nov. lk. 2, Hiiu Leht 22. nov. lk. 2, Vooremaa 24. nov. lk. 2. Autor leiab, et kohustuslik ajateenistus Eestis ei taha vajalikku taset

  13. Mehel kogu aeg madu peas / Mats Õun

    Index Scriptorium Estoniae

    Õun, Mats, 1964-

    2001-01-01

    Pedagoogi ja psühholoogiharidusega kunstnik ja luuletaja Knut Andresen (sünd. 1938 Friedrichstadtis Põhja-Friisimaal) on tegelnud ka psüühiliselt haigete ja vaimupuudega inimestega, tema maalide näitusest "Mao müüt I" Viljandi Kunstisaalis

  14. Müüride langemise aeg / Reet Varblane

    Index Scriptorium Estoniae

    Varblane, Reet, 1952-

    1999-01-01

    16. jan.-ni 2000 Moderna Museetis avatud Kesk- ja Ida-Euroopa kunsti näitusest "Pärast müüri". Kuraatorid: B. Pejic, D. Elliott, I. Müller-Westermann. Osalejad Eestist: I. Josing, K. Kaljo, L. Siib, J. Toomik. D. Elliotti kataloogi eessõnast (O. Rabini ja C. Andre tööde võrdlus). D. Elliott näituse retseptsioonist Rootsis

  15. Igal õunal oma aeg puu pealt kukkuda / Silvia Viidik

    Index Scriptorium Estoniae

    Viidik, Silvia, 1972-

    2008-01-01

    Apple tegi pühadeperioodi ostuhinnas allahindlusi 10% samal ajal, kui konkurendid tegid kuni 50 protsendilisi soodustusi. Apple'i juhi Steve Jobsi sõnul ta Macide hindu veel kärpima ei hakka, kuna pole väga mures nõudluse vähenemise pärast. Diagrammid: Apple'i aktsia hind; Majandustulemused

  16. Paljudele puhkus, noortele ärev aeg / Tõnis Lukas

    Index Scriptorium Estoniae

    Lukas, Tõnis, 1962-

    2002-01-01

    Ilmunud ka: Pärnu Postimees 1. august lk. 10, Lääne-Harju Ekspress 3. august lk. 2, Hiiumaa 1. august lk. 2, Põhjarannik ; Severnoje Poberezhje 1. august lk. 2, Elva Postipoiss 3. august lk. 6, Meie Maa 2. august lk. 2, Hiiu Leht : Käina Kuller 6. august lk. 4, Järva Teataja 6. august lk. 2, Vooremaa 6. august lk. 2, Valgamaalane 6. august lk. 2, Nädaline 8. august lk. 4, Lääne Elu 6. august lk. 4, Tartu : Postimees 9. august lk. 2, Harjumaa 13. august lk. 3, Koit 13. august lk. 6, Harju Uudised 7. august lk. 9. Riigikogu liikme sõnul võivad palgavahed korraliku hariduse ühele osale Eesti elanikest kättesaamatuks teha. Autor: Isamaaliit. Parlamendisaadik

  17. Araabia isevalitsejate aeg on ümber saamas

    Index Scriptorium Estoniae

    1999-01-01

    Araabia valitsejatest: Saudi Araabia kuningas Fahd, Liibüa president Muammar Kaddafi, Palestiina president Yassir Arafat, Iraagi president Saddam Hussein, Maroko president Hassan II, Süüria president Hafez Assad, Egiptuse president Hosni Mubarak

  18. Religioosne aeg, religioosne inimene / Ülo Mattheus

    Index Scriptorium Estoniae

    Mattheus, Ülo, 1956-

    1995-01-01

    Vastukaja : Habicht, Juhan. Kõiketeadja on juba meie keskel?// Eesti Ekspress. - 1995. - 25.aug. - Lk.A5; Mattheus, Ülo. Kirjanike kirjavahetus // Eesti Ekspress. - 1995. - 8.sept. - Lk.A5; Liimets, M. [Vastukaja] // Eesti Ekspress. - 1995. - 8.sept. - Lk.A5

  19. John McCain : muutuste aeg tulgu! / Tõnis Erilaid

    Index Scriptorium Estoniae

    Erilaid, Tõnis, 1943-

    2008-01-01

    John McCain kuulutati vabariiklaste ametlikuks presidendikandidaadiks ning parteikongressil peetud kõnes lubas ta muutusi, mida eelnevalt oli lubanud ka tema demokraadist konkurent Barack Obama. Vt. samas: Rünnakud Sarah Palinile ei lõpe

  20. Värviline aeg / Liina Hergauk ja Evelin Samuel

    Index Scriptorium Estoniae

    Hergauk, Liina

    2015-01-01

    Värviliste triipudega pontšo, roosa lapitehnikas jakk, kollane puude ja pilvedega kampsun, kirju mantel - autor Jelena Tikunova. Õrn must-punane õlasall - autor Anna Verschik. Sinine põimribadega kampsun - autor Natalia Lill. Helelilla mantel - autor Karin Pärtel. Triibuline kampsun tütarlapsele - autor Liina Hergauk.

  1. Dostojevski aeg / Boris Tuch ; tõlk. Madis Kolk

    Index Scriptorium Estoniae

    Tuch, Boris, 1946-

    2007-01-01

    Dostojevski kangelased Eesti teatrilaval: "Onu unenägu" Vene Teatris (lavastaja Mihhail Tshumatshenko), Matthias Andersoni "Kuritöö, kodutööd, karistus, raha, pensionäri tapmine" Drugoi Teatr (lavastajad Erki Aule ja Artjom Garejev), Eesti - Läti - Leedu vene teatrite koostööprojekt "Russki smehh" (lavastaja Roman Kozak), "Sortsid" Eesti Draamateatris (lavastaja Hendrik Toompere jun.), "Krokodill" Vana Baskini Teatris (lavastaja Mark Rozovski)

  2. "Vana hea aeg" baltisaksa mälestusteraamatus / Ahti Saares

    Index Scriptorium Estoniae

    Saares, Ahti

    2000-01-01

    Baltisakslastest memuariste iseloomustab romantilis-patriootiline suhtumine kodumaasse ja sellest lähtuv kultuuritoojalik, kõrgemat missiooni täitev hoiak. Võrdlus Stefan Zweigi, Sven Danelli ja Kaljo Villako mälestusteraamatutega

  3. On aeg taguda trumme Steadfast Jazzi toetuseks / Edward Lucas

    Index Scriptorium Estoniae

    Lucas, Edward, 1962-

    2013-01-01

    2013. a. novembris toimuvast NATO viimase 20 aasta kõige suuremast õppusest, mille käigus harjutavad liitlasväed liikmesriikide territooriumide kaitsmist. Õppus kannab nime SFJZ13 või Steadfast Jazz 2013

  4. Myanmari aitab üksnes aeg / Mihkel Mutt

    Index Scriptorium Estoniae

    Mutt, Mihkel, 1953-

    2007-01-01

    Myanmaris (Birmas) toimunud buda munkade meeleavaldusest, hunta tegevusest ja suhetest Hiinaga. Autori hinnangul võib valitsev diktatuur aru saada muutuste paratamatusest ja hakata riiki Hiina kombel ülaltpoolt reformima

  5. Moodne aeg käib alla / Valner Valme

    Index Scriptorium Estoniae

    Valme, Valner, 1970-

    2008-01-01

    Arvustus: Beigbeder, Frédéric. Armastus kestab kolm aastat : romaan / prantsuse keelest tõlkinud Anti Saar. Tallinn : Varrak, 2008 ; Cusk, Rachel. Arlington Park / tõlkinud Kersti Unt. Tallinn : Varrak, 2007

  6. Sakala arhitekt Raine Karp : uus aeg nõuab teistsuguseid karpe / Ants Juske

    Index Scriptorium Estoniae

    Juske, Ants, 1956-

    2006-01-01

    Raine Karbi elust ja loomingust, mõtteid Sakala keskuse projekteerimisest, ehitamisest ja ümberehitamisest. Karin Hallas-Murula kommentaar "Tõstis paekivi taas ausse" ja Ivi Eenmaa kommentaar "Teadis raamatukogust hämmastavalt palju"

  7. Aeg on otsustada : Rail Baltica : rahvusvaheline raudtee toob Eestile kasu / Vilja Savisaar-Toomast

    Index Scriptorium Estoniae

    Savisaar-Toomast, Vilja, 1962-

    2011-01-01

    Vilja Savisaar-Toomast on kindel, et Rail Baltica projekt tuleb esitada Euroopa Liidu finantsperioodiks 2014-2020 ning eelistab marsruuti Tallinn-Pärnu-Riia-Kaunas. Tõenäoliselt on võimalik saada projektile Euroopa Liidult ka maksimumtoetus ehk määraga 60-70%

  8. Uus aeg ja uus kunst ulatavad Pärnus terekäe / Siram

    Index Scriptorium Estoniae

    Siram, pseud., 1968-

    2010-01-01

    Näitus "New Age" Pärnu Kunstnike majas 23. aprillini 2010, kuraator Sandra Jõgeva. Lähemalt Maigi Magnuse kineetilisest skulptuurist "Ema mängib surnut", ameerika kunstniku Meghan Van Alstyne tööst "Uskujad"

  9. UJI TOKSISITAS BEBERAPA EKSTRAK TANAMAN TERHADAP LARVA AEDES AEgYPTI VEKTOR DEMAM BERDARAH DENGUE

    Directory of Open Access Journals (Sweden)

    Hasan Boesri

    2015-09-01

    Full Text Available Mosquito vector control are still using insecticide  from pyrethroid, carbamates and organophosphates groups because they are effective, having fast result but having less concern for the negative impact to the environment. In order to solve the side effects the side effect, it was necessary to find bio-insecticides which are sustainable, accessible and effective to kill mosquitoes and larvae. In this study the extract of Nicotiana tabacum / tobacco with minimum concentration of 1,56 % was effective to kill larvae with of 100% mortality, with of LC90  0,628 %, LC50 0,194 %. The extract contain chemical dominant alkaloids, Euvodia gravolens / zodiac with minimum concentration 1,56 % the mortality effects 100%, is with LC90 0,628 %, and LC50 0,194 %, the extract concentration 1,56 %, the mortality effect is 100 %, is with LC90a of 0,628% and dominant chemical contains Evodiamine, Alpinia galanga/ of  / galanga with minimum concentration of 1,56 %, the mortality effects is 29,3% and LC90 8,216 %, LC50 2,980 % and dominant chemical contain flavonoids, Andropogon nardus/ lemongrass with minimum concentration of 1,56% the mortality effect is 68% and LC90 4,898 %, LC50 1,068 % and dominant chemical contain of vetivetate acid, rosemary ( Rosmarinus officinalis L with minimum concentration of 1,56% gives mortality effect 78,7% and LC90 3,175 %, LC50 0,659 %. The dominant contain of the chemical is alkaloid = Pengendalian  nyamuk vektor masih menggunakan bahan insektisida dari golongan piretroid, karbamat, dan organofosfat karena  efektif, cepat diketahui hasilnya, namun kurang memperhitungkan dampak negatif terhadap lingkungan. Oleh sebab itu perlu dicari insektisida alernatif, yaitu insektisida nabati yang ramah lingkungan, mudah diperoleh, efektif membunuh nyamuk dewasa dan pradewasa. Pada penelitian diperoleh hasil Nicotiana tabacum/tembakau konsentrasi ekstrak minimal 1,56%, mampu membunuh larva nyamuk sebesar 100 % dan LC90 0,628 %, LC50 0,194 %, (kandungan kimia dominan  alkaloid, Euvodia gravolens/ zodia dengan konsentrasi ekstrak minimal ekstrak 1,56 % mampu memberikan efek kematian 100% dan LC90 0,628.% ,LC50 0,194 % (kandungan kimia dominan  Evodiamine,. Alpinia galanga/lengkuas konsentrasi ekstrak minimal 1,56 % mampu memberikan efek kematian 29,3 % dan LC90 8,216 % ,LC50 2,980 % (kandungan kimia dominan  flavonoida, Andropogon nardus/serai wangi konsentrasi ekstrak minimal 1,56% mampu membunuh larva nyamuk sebesar 68 % dan LC90 4,898 %, LC50 1,068 % ( kandungan kimia dominan  asam vetivetate, Rosemary (Rosmarinus officinalis L konsentrasi ekstrak minimal 1,56%, memberikan efek kematian sebanyak 78,7 % dan LC90 0,659 %, LC50 3,175 % (kandungan kimia dominan alkaloid.

  10. Aeg on hakata parke ja platse arukalt täis ehitama / Tõnu Kann

    Index Scriptorium Estoniae

    Kann, Tõnu, 1957-

    2005-01-01

    Pärnu linnavalitsuse planeerimisosakonna 1996. aasta kesklinna arengu ideekavandist, tühjade kvartalinurkade täisehitamisest, vanade tänavajoonte taastamisest. Kommenteerivad Tõnu Kann ja arhitekt Rein Raie

  11. Videoinstallatsiooni aeg pole ümber : muljeid Amsterdami videofestivalilt / Kai Kaljo

    Index Scriptorium Estoniae

    Kaljo, Kai, 1959-

    1999-01-01

    17. World Wide Video Festival 15.-20. IX Amsterdamis Melkwegi keskuses ja Stedelijki muuseumis. Väljapanekust. Kai Kaljolt oli videofestivalil väljas 'One Way to See America'. Seminaride materjalid: wwvf@wwvf.demon ja www.wwvf.nl

  12. Peter Lorange: on aeg hakata uuesti investeerima / Peter Lorange ; intervjueerinud Viljar Rääsk

    Index Scriptorium Estoniae

    Lorange, Peter, 1943-

    2009-01-01

    Šveitsis tegutseva Rahvusvahelise Juhtimiskooli endise juhi hinnangul peaksid valitsused majandusliku languse tingimustes suunama raha infrastruktuuri arendamisse, pakkuma ettevõtjatele maksuvabastusi ja vähendama bürokraatiat

  13. Design of an Automated Essay Grading (AEG) System in Indian Context

    Science.gov (United States)

    Ghosh, Siddhartha; Fatima, Sameen S.

    2007-01-01

    Automated essay grading or scoring systems are no more a myth, but they are a reality. As of today, the human written (not hand written) essays are corrected not only by examiners/teachers but also by machines. The TOEFL exam is one of the best examples of this application. The students' essays are evaluated both by human and web based automated…

  14. Ülo Soosteri aeg / Lidia Sooster ; tõlk. Aili Künstler

    Index Scriptorium Estoniae

    Sooster, Lidia, 1926-1999

    1998-01-01

    Katkend kunstnik Ülo Soosteri abikaasa Lidia Soosteri mälestustest, mis ilmusid Tel Avivis vene-juudi kunstikeskuse ajakirjas "Peegel" (Zerkalo, 1997, nr. 5-6, lk. 181-231). Moskva algusaastatest. Ülo Soosterist, Moskva kunstielust. Järgneb 23. jaan. 1998, lk. 8

  15. Hea töötaja leidmine: viimane aeg on tegutseda / Mariliis Aigro

    Index Scriptorium Estoniae

    Aigro, Mariliis

    2014-01-01

    Maailma parimad ettevõtted-tööandjad panustavad töötajate arendamisse, peavad oluliseks töötajate erialast arengut ja karjääriteed, erilist tähelepanu pööratakse juhtide ja nende järelkasvu arendamisse.

  16. Aeg on valla päästa peidetud anded / Silja Joon

    Index Scriptorium Estoniae

    Joon, Silja, 1966-

    2009-01-01

    Tutvustatakse Pärnu kunstikoolis, Pärnu kunstnike majas, Nooruse maja rahvaülikoolis, Jüri ja Vadim Vlassovi fotostuudios, Eva-Lotta kunstiäris ja Paikuse huvikoolis pakutavaid kunstikursusi täiskasvanutele

  17. Henri Tamm : algul küsiti mult kogu aeg autogrammi / Henri Tamm ; interv. Ada Kallam

    Index Scriptorium Estoniae

    Tamm, Henri

    2005-01-01

    Draamaseriaali "Kodu keset linna" lapsnäitleja. Lisaks kolleegid Henrist : M. Veinmann "Tekst on tal esimesena peas", K. Maibaum "Võrdväärne partner suurtele". Artikkel pealkirjaga "Henri Tamm : nüüd saan veidi puhkust" : Linnaleht nr. 22, 3. juuni 2005, A2-A3

  18. Kehaline kasvatus - mängule kadunud aeg ja ruum? / Joe Noormets

    Index Scriptorium Estoniae

    Noormets, Joe

    2004-01-01

    Autori väitel on üldhariduskooli kehalise kasvatuse tundidesse tunginud üha enam spordile omaseid tegevusmudeleid ja väärtusorientatsioone; mäng ja mängulisus on kehalises kasvatuses kaduma läinud

  19. EFIKASI LARVASIDA TEMEPHOS TERHADAP AEDES AEgYPTI RESISTEN PADA BERBAGAI KONTAINER

    Directory of Open Access Journals (Sweden)

    Riyani Setiyaningsih

    2015-09-01

    Full Text Available Dengue hemorrhagic fever (DHF is a disease that causes death in Indonesia. Management DHF can be done with contol vector. One technique is the vector control with larvicides temephos. The use temephos already widely used by the people in the control larvae of Ae. aegypti. In the community can be used in applications temephos in some types of containers. The aims of the study to determine the efication of the various containers temephos against Ae. aegypti resistant. Test the efication of the various containers temephos 7 containers are carried on clay, cement, stainless steel, enamel, cans, plastics, plastics recycling and not recycling. Based on the research results temephos still effectively kill mosquito larvae Ae.aegypti resistant containers made   of clay for eight months, enamel effective container for the application of ten months, tin containers, cement and stainless steel effective until the eleventh month. In plastic containers to more effective application temephos fourteenth month=Demam berdarah dengue (DBD merupakan salah satu penyakit yang menyebabkan kematian di Indonesia. Upaya pengendalian DBD dapat dilakukan dengan pengendalian vektor. Salah satu teknik pengendalian vektor adalah dengan larvasida temephos. Penggunaan temephos sudah banyak digunakan masyarakat dalam pengendalian jentik Ae. aegypti. Aplikasi temephos di masyarakat digunakan pada berbagai jenis kontainer. Penelitian bertujuan untuk mengetahui efikasi penggunaan temephos pada berbagai kontainer terhadap Ae. aegypti resisten. Uji efikasi temephos pada berbagai kontainer dilakukan pada 7 kontainer yaitu tanah liat, semen, stainless steel, enamel, kaleng, plastik daur ulang dan plastik tidak daur ulang. Hasil penelitian menunjukkan temephos masih efektif membunuh jentik Ae.aegypti resisten pada kontainer yang terbuat dari tanah liat selama delapan bulan, enamel efektif selama sepuluh bulan, kontainer kaleng, semen dan stainless steel efektif sampai bulan kesebelas. Kontainer plastik aplikasi themephos efektif sampai empatbelas bulan.

  20. Euroreferendumi aeg jääb veel lahtiseks / Liia Hänni

    Index Scriptorium Estoniae

    Hänni, Liia, 1946-

    2001-01-01

    Euroreferendumi korraldamisest. Autor: Rahvaerakond Mõõdukad. Parlamendisaadik. Ilmunud ka: Hiiumaa, 3. mai 2001, lk. 2; Nädaline, 3. mai 2001, lk. 4; Võrumaa Teataja, 5. mai 2001, lk. 2; Sakala, 8. mai 2001, lk. 2; Virumaa Teataja, 9. mai 2001, lk. 7; Järva Teataja, 11. mai 2001, lk. 2; Lääne Elu, 26. mai 2001, lk. 4

  1. Gazprom teeb reformi: Ukrainal on aeg gaasipliidid nurka visata / Heiki Suurkask

    Index Scriptorium Estoniae

    Suurkask, Heiki, 1972-

    2009-01-01

    Autor leiab, et Ukraina pole 2006. a. kriisist midagi õppinud, maagaasi tarbimine on veelgi suurenenud. Gaasihinna tõusu korral hakatakse Ukrainas ilmselt üha enam loobuma gaasipliitidest ja -boileritest ning niimoodi kaotaks Gazprom ühe oma suurema turu. Gazprom üritab kõrgemat gaasihinda saavutada ka SRÜ maades. Diagrammid

  2. Offshore-firmade müügis keeruline aeg / Anne Oja

    Index Scriptorium Estoniae

    Oja, Anne, 1970-

    2004-01-01

    Offshore-firmasid ostetakse läbi advokaadibüroode ja audiitorfirmade. 2001. aastal tehtud uuringu järgi käis Eesti ettevõtjate kontrolli all olevatest offshore-ettevõtetest läbi 6 miljardit krooni aastas

  3. Erastamisväärtpaberite aeg lõpeb / Signe Kalberg

    Index Scriptorium Estoniae

    Kalberg, Signe, 1959-

    2005-01-01

    Füüsiliste isikute kasutusarvetel on praegu ligi 560 miljonit EVP-krooni. Maa, ehitiste, aktsiate ja muu vallasvara kompenseerimiseks on välja antud üle 8,4 miljardi EVP-krooni, ligi 90% füüsiliste isikute kasutusarveid on praeguseks kas täiesti tühjad või on neile jäänud erastamistehingutes kasutamiseks liiga väike summa. Miljoni kroonini ulatuvaid arveid on füüsilistel isikutel vaid kolm

  4. Eesti kaubanduses on võimaluste aeg läbi saanud / Villu Zirnask

    Index Scriptorium Estoniae

    Zirnask, Villu, 1966-

    2007-01-01

    Konsultatsioonifirma A.T. Kearny igaaastane raport Global Retail Development Index hindab olukorda Eesti ja Leedu kaubandusturul igavaks ja leiab, et Balti jaeturg muutub väga küllastunuks. Vt. samas: Majanduskliima: Maailma jaeturgude atraktiivsus; Maailma suurimad jaemüügifirmad; Edetabel: Maailma 10 kõige atraktiivsemat jaekaubandusturgu; Kuidas mõõta turu perspektiivikust?

  5. 50 aastat Euroopa integratsiooni: aeg uueks alguseks / Hans-Gert Pöttering

    Index Scriptorium Estoniae

    Pöttering, Hans-Gert, 1945-

    2007-01-01

    Ilmunud ka: Virumaa Teataja, 23. märts 2007, lk. 1; Pärnu Postimees, 24. märts 2007, lk. 19; Koit, 24. märts 2007, lk. 6; Põhjarannik, 24. märts 2007, lk. 2; Severnoje Poberezhje, 24. märts 2007, lk. 2. Euroopa Parlamendi presidendi Hans-Gert Pötteringi mõtted Euroopa Ühenduse asutamislepingu sõlmimise 50. aastapäeva puhul

  6. On aeg mängida! / Ell-Maaja Randküla

    Index Scriptorium Estoniae

    Randküla, Ell-Maaja, 1939-2016

    2005-01-01

    Tartu Mänguasjamuuseumi (Tartu, Lutsu t. 8) sisekujundus. Autorid: Tea Tammelaan, Krista Lepland, Malle Jürgenson, OÜ Laika, Belka & Strelka. Maalitud põrandavaip: Kai Kaljo. Maalitud pitslinad: Tuuli Puhvel. Ehitaja: AS Facio Ehitus. Eesti Sisearhitektide Liidu 2004. a. aastapreemiate konkursil pälvis ajaloolise interjööri preemia. T. Tammelaanest, K. Leplandist ja M. Jürgensonist, OÜ Laika, Belka & Strelka tähtsamad tööd. Ill.: plaan, 23 värv. vaadet

  7. Ibn Tufail : tema aeg, elu ja koht islami-araabia filosoofia ajaloos / Haljand Udam

    Index Scriptorium Estoniae

    Udam, Haljand, 1936-2005

    2001-01-01

    Varem ilmunud järelsõnana raamatus: Elav Ärganu poeg. Tallinn : Olion, 1992. 12. sajandil Araabia Hispaanias elanud filosoof Abu Bakr Muhammad ibn Abd al-Malik ibn Muhammad ibn Muhammad ibn Tufail. Tema põhiteosest, filosoofilisest jutustusest "Elav Ärganu poeg"

  8. 42. Nordische Filmtage Lübeck, vahekokkuvõtete aeg / Lauri Kärk

    Index Scriptorium Estoniae

    Kärk, Lauri, 1954-

    2000-01-01

    Lübeckis toimunud Põhjamaade filmipäevade 42. Nordische Filmtage huvitavamatest filmidest, festivali juhi vahetusest. Baltikumi esindas lühifilmide kassett "Sellised kolm lugu", mille üks autor Ervin Õunapuu ka kohal viibis

  9. A position sensitive silicon detector for AEgIS (Antimatter Experiment: Gravity, Interferometry, Spectroscopy)

    CERN Multimedia

    Gligorova, A

    2014-01-01

    The AEḡIS experiment (Antimatter Experiment: Gravity, Interferometry, Spectroscopy) is located at the Antiproton Decelerator (AD) at CERN and studies antimatter. The main goal of the AEḡIS experiment is to carry out the first measurement of the gravitational acceleration for antimatter in Earth’s gravitational field to a 1% relative precision. Such a measurement would test the Weak Equivalence Principle (WEP) of Einstein’s General Relativity. The gravitational acceleration for antihydrogen will be determined using a set of gravity measurement gratings (Moiré deflectometer) and a position sensitive detector. The vertical shift due to gravity of the falling antihydrogen atoms will be detected with a silicon strip detector, where the annihilation of antihydrogen will take place. This poster presents part of the development process of this detector.

  10. Transgenic expression of medicago truncatula PR10 and PR5 promoters in alfalfa shows pathogen-induced up-regulation of transgene expression

    Science.gov (United States)

    Genetic modification of alfalfa to introduce novel traits requires promoters for controlling gene expression. Promoters that are constitutively activated for expression of genes that enhance disease resistance pose a great energy load on the plant and exert a strong selective pressure on the pathoge...

  11. Primary structures of two ribonucleases from ginseng calluses - New members of the PR-10 family of intracellular pathogenesis-related plant proteins

    NARCIS (Netherlands)

    Moiseyev, GP; Fedoreyeva, LI; Zhuravlev, YN; Yasnetskaya, E; Jekel, PA; Beintema, JJ

    1997-01-01

    The amino acid sequences of two ribonucleases from a callus cell culture of Panax ginseng were determined, The two sequences differ at 26% of the amino acid positions, Homology was found with a large family of intracellular pathogenesis-related proteins, food allergens and tree pollen allergens from

  12. Tallinna Raekoda. Aeg ja lugu = Tallinn Town Hall - Its Story Through Time / Elvira Liiver Holmström

    Index Scriptorium Estoniae

    Liiver Holmström, Elvira

    2004-01-01

    Raekoja kujunemislugu. Esindussaalid, ameti- ja tarberuumid. Raekoda 17.-20. sajandil. Hoone ümberehitamist 1402-1404 juhtis kiviraidur Ghercke. Hinrik Hartmanni poolt valatud kell paigutati torni 1586. a. 17. sajandil tegi hilisrenessanss-stiilis torni joonised Geiger Graff, lääneviilule uue harjakivi ja tuulelippu hoidva lõvi Hans Damm, lohepeakujulised veesülitid ja tuulelipu lipu Daniel Pöppel, raesaali paigutati Johann Akeni lünettmaalid, nende all paikneva puitnikerdfriisi valmistasid Elert Thiele ja Joachim Armbrust. 1859. a. ümberehitusprojekti koostas Christoph August Gabler

  13. Elutervik ja aeg : murdkem püramiidi võim / Sigmund Kvaloy ; tõlk. Tiiu Speek

    Index Scriptorium Estoniae

    Kvaloy, Sigmund

    2005-01-01

    Nüüdisaegsest ökofilosoofiast, tööstusliku kasvu ühiskonna ja eluliste vajaduste ühiskonna vastuoludest ning Norra ökopoliitikast. Lisatud lühiülevaade autori elukäigust. Vt. ka: David Rothenberg. Elutervik ja elulised vajadused: Eesti tee

  14. Kas on õige aeg palka juurde küsida? / Melika Kiilmaa, Henri Lehtsaar, Katrin Talvak... [jt.

    Index Scriptorium Estoniae

    2010-01-01

    Küsimusele vastavad EMT juriidilise osakonna juhataja Melika Kiilmaa, Sõbralt Sõbrale kaupluseketi arendaja ja Eesti kristliku juhtimiskonverentsi peakorraldaja Herni Lehtsaar, Estonian Airi turundusjuht Katrin Talvak, Swedbank Investeerimisfondide töötaja ja Taco Expressi omanik Jarno Edur, Arista HRS vanemkonsultant Roland Luik

  15. Professor Trechsel : Eesti e-valimiste aeg on liiga lühike / Alexander H. Trechsel ; interv. Askur Alas

    Index Scriptorium Estoniae

    Trechsel, Alexander H.

    2006-01-01

    e-valimistele pühendatud rahvusvahelisel konverentsil esinenud Genfi ülikooli e-demokraatia keskuse juhataja, poliitikateaduste professor Eesti e-valimistest ja e-valimiste tulevikust. Vt. samas: Askur Alas. Konverentsil analüüsiti e-valimiste kogemusi; Eestis hääletas digitaalselt 9317 valijat

  16. Lineaarse kunstiajaloo aeg on otsas / Edit András ; intervjueerinud R[eet] V[arblane

    Index Scriptorium Estoniae

    András, Edit

    2010-01-01

    Vestlus ungari kunstiteoreetiku- ja ajaloolase Edit Andrásiga, kes osales Tallinnas USA Clarki instituudi ja EKA Kunstiteaduste Instituudi seminaril, kus arutati Kesk- ja Ida-Euroopa kunstiajaloo kirjutamisviiside üle. Seminari tekkimisest, kokkusaamise põhjustest, seminari järeldustest, Eesti ja Ungari kunstiajaloo kirjutamise erinevatest põhimõtetest jm.

  17. Väljastpoolt Euroopat Eestisse lendajate check-inþi aeg pikeneb / Jan Jõgis-Laats

    Index Scriptorium Estoniae

    Jõgis-Laats, Jan

    2007-01-01

    1. juulist 2007 jõustunud riigipiiri seaduse muudatusest, mille kohaselt on lennufirmadel kohustus edastada piirivalvele Euroopa Liidu välistest riikidest Eestisse saabuvate lennureisijate isikuandmed. Lisatud: seadusemuudatuse nõuab lisaandmeid

  18. Elutervik ja aeg : murdkem püramiidi võim / Sigmund Kvaloy ; tõlk. Tiiu Speek

    Index Scriptorium Estoniae

    Kvaloy, Sigmund

    2005-01-01

    Nüüdisaegsest ökofilosoofiast, tööstusliku kasvu ühiskonna ja eluliste vajaduste ühiskonna vastuoludest ning Norra ökopoliitikast. Lisatud lühiülevaade autori elukäigust. Vt. ka: David Rothenberg. Elutervik ja elulised vajadused: Eesti tee. Lk. 549

  19. Ida-Virul on aeg oma võimalused välja mängida / Mart Laar

    Index Scriptorium Estoniae

    Laar, Mart, 1960-

    2008-01-01

    Ilmunud ka: Severnoje Poberezhje : Ida-Virumaa Zavtra 15. mai, lk. 4. Ekspeaministrist IRL-i esimehe Mart Laari hinnangul on Ida-Virumaa eduka arengu võtmeküsimused korruptsiooni ja kuritegevuse vähendamises ning ettevõtluskeskkonna parandamises

  20. Deleuze, filmikunst ja rahvuslik identiteet : narratiivi aeg rahvuslikes kontekstides / David Martin-Jones ; tõlkinud Eva Näripea

    Index Scriptorium Estoniae

    Martin-Jones, David

    2011-01-01

    Antakse ülevaade Gilles Deleuze'i filmitekstidest "Kino 1 : liikumispilt" (Cinếma-1 : l'image-mouvement) ja "Kino 2 : ajapilt" (Cinếma-2 : l'image-temps) ning K. Bhabha artiklist "DissemiNatsioon" kogumikust "Rahvus ja jutustamine" (Nation and Narration,1990), kus käsitletakse ideesid narratiivist, ajast ja rahvuslikust identiteedist. Uuritakse, kuidas käsitletakse narratiivi aja kaudu ajalugu ja identiteeti ning missugust toimet avaldab see rahvusliku identiteedi konstrueerimisele

  1. Rattarändurid : naistel on mõistlik mehed aeg-ajalt kodust ära lasta / Greta Kaupmees

    Index Scriptorium Estoniae

    Kaupmees, Greta

    2007-01-01

    Täna hommikul stardib Terevisiooni ärataja Priit Kuusk koos viie ränduriga Tallinnast Katmandusse, et sealt edasi asuda maid avastama jalgratastel. Seiklejatel on plaanis sõita nelja kuuga ligi 4000 kilomeetrit ehk Katmandust Teherani. Rattaretkest valmib ETV-s taas dokumentaalsari "Ehh, uhhuduur"

  2. Mis on jumal? / Olev Remsu

    Index Scriptorium Estoniae

    Remsu, Olev, 1947-

    1995-01-01

    Vastukaja : Raudsepp, Jüri. Kas Eesti Aeg on mööda saamas?// Eesti Aeg. - 1995. - 19.juuli. - Lk.11; Remsu, Olev. Lugupeetud Jüri Raudsepp.!// Eesti Aeg. - 1995. - 19.juuli. - Lk.11. Uring, Priit. Remsule sekundeerides // Eesti Aeg. - 1995. - 2.aug. - Lk.11

  3. Thermodynamic characterization of the PR-10 allergens Bet v 1, Api g 1 and Dau c 1 and pH-dependence of nApi g 1 and nDau c 1

    NARCIS (Netherlands)

    Bollen, M.A.; Wichers, H.J.; Helsper, J.P.F.G.; Savelkoul, H.F.J.; Boekel, van M.A.J.S.

    2010-01-01

    Natural and recombinant Bet v 1, the major birch pollen allergen, and homologous allergens, Api g 1 and Dau c 1, from celery and carrot, respectively, were studied by CD spectroscopy under conditions of varying denaturant concentration, pH and temperature to determine fundamental thermodynamic param

  4. Kas ülikoolis õppimine on õige aeg lapse sünnitamiseks? / Ilona Opaal, Liis-Erliken Vinne, Tõnu Ots ... [jt.

    Index Scriptorium Estoniae

    2008-01-01

    Küsimusele vastavad TLÜ anglistikaüliõpilane Ilona Opaal, TLÜ bioloogiaüliõpilane Liis-Erliken Vimme, psühholoog Tõnu Ots, filosoof Valdar Parve, Soome Instituudi direktor Jaana Vasama, psühholoog Tiia Lister, Treffneri Gümnaasiumi usu- ja filosoofiaõpetaja Toomas Jürgenstein

  5. Vallutamise aeg on Helmandis möödas, nüüd on tarvis vastased eemal hoida / Lauri Tankler

    Index Scriptorium Estoniae

    Tankler, Lauri

    2012-01-01

    Estcoy-14 kompanii ülema major Eero Aija sõnul on Eesti üksuse tähtsaim ülesanne rahulike elanike kaitsmine , mitte kõrbe vallutamine. 2013. aasta lõpuks peaks vastutus sõjategevuse eest olema üle antud Afganistani Rahvusarmeele, keda selle jaoks ka välja õpetatakse

  6. Hüpped modernismi poole II : 20. sajandi eesti kirjandusteadus Euroopa kirjandusteaduse taustal. 4. loeng : Eesti kirjandus ja selle uurimine 19. sajandil : romantilise idealismi aeg / Tiit Hennoste

    Index Scriptorium Estoniae

    Hennoste, Tiit, 1953-

    2006-01-01

    Ka eesti 19. sajandi kirjanduslugudest: Dietrich Heinrich Jürgensoni "Kurze Geschichte der ehstnischen Literatur" (1843-44), August Ahlqvisti "Viron nykyisemmästä kirjallisuudesta" (1855), Karl August Hermanni "Eesti kirjanduse ajalugu esimesest algusest meie ajani" (1898) ja Tõnu Sanderi "Eesti kirjanduse ajalugu" (1. osa 1899, 2. osa 1901)

  7. Aeg on Soome ja Rootsi töösturid kinni püüda / Taivo Paju, Kärt Blumberg

    Index Scriptorium Estoniae

    Paju, Taivo, 1968-

    2008-01-01

    Ettevõtete edutegurite üle arutlevad Arengufondi juhatuse liige Heido Vitsur, Balti Uuringute Instituudi juhatuse esimees Marek Tiits, TTÜ mehhaanikateaduskonna professor Rein Küttner. Vt. samas: Ketlin Priilinn. Metsikult kallis küll, kuid seda väärt; Merike Teder. Uute seadmeteta oleksime kadunud (ilmunud ka Molodjozh Estonii : Biznes Sreda 16. apr. lk. 8); Taivo Paju. Pelmeenikuningas Ivan Zakotei (ilmunud ka Molodjozh Estonii : Biznes Sreda 30. apr. lk. 11); Poolteist kuud ja tehas töökorras

  8. Apellatsioonimenetluse aeg tsiviilasjades Eesti Vabariigis ja seda mõjutavad tegurid : [magistritöö] / Sirje Viherpuu ; Tartu Ülikool, õigusteaduskond ; juhendaja: Mare Merimaa

    Index Scriptorium Estoniae

    Viherpuu, Sirje, 1969-

    2013-01-01

    Mõistlikust menetlusajast ja selle eesmärgist tsiviilkohtumenetluses, menetlusajast Eesti Vabariigis apellatsioonimenetluses tsiviilasjade läbivaatamisel, takistavatest teguritest ja võimalustest menetluse kiirendamiseks

  9. The role of endoscopic ultrasound guided fine needle aspiration (EUS-FNA in non small cell lung cancer (NSCLC patients: SEED-SEPD-AEG Joint Guideline

    Directory of Open Access Journals (Sweden)

    Enrique Vázquez-Sequeiros

    2013-04-01

    Full Text Available Lung cancer is one of the most frequent neoplasms in our environment, and represents the first cause of cancer related death in western countries. Diagnostic and therapeutic approach to these patients may be complicated, with endoscopic ultrasound guided fine needle aspiration (EUS-FNA, classically performed by gastroenterologists, playing a very important role. As this disease is not closely related to the "digestive tract", gastroenterologists have been forced to update their knowledge on this field o adequately diagnose this significant group of patients. The recent advent of modern and promising techniques like endobronchial ultrasound guided fine needle aspiration (EBUS-FNA have prompted new approaches for diagnosis and staging of this type of patients. In this clinical guideline, the "Sociedad Española de Endoscopia Digestiva" (SEED, "Sociedad Española de Patología Digestiva" (SEPD and the "Asociación Española de Gastroenterología", have jointed efforts to update the existing knowledge on the field and provide their members with evidence based recommendations.

  10. 1 küsimus noorele juhile : Kui raha ja aeg ei piira, siis mida tahaksite elus juurde õppida? / Jekaterina Eilart, Andres Urb, Mariana Kolesnik... [jt.

    Index Scriptorium Estoniae

    2010-01-01

    Küsimusele vastavad Hamburg ja Partnerid töötaja Jekaterina Eilart, Sampo Life Eesti varahaldur Andres Urb, Marati peadisainer Mariana Kolesnik, katusefirma Evari juht Rain Kala, endine tudengiorganisatsiooni AIESEC Eesti president Lauri Lahi ning internetiturundaja Marjam Vaher

  11. Ilmus väärt artiklikogumik / Arvo Tering

    Index Scriptorium Estoniae

    Tering, Arvo, 1949-

    2008-01-01

    Arvustus: Ajalookirjutaja aeg = Aetas historicum / Eesti Rahvusraamatukogu ; koost. Piret Lotman. - Tallinn, 2008. - 247 lk. - (Eesti Rahvusraamatukogu toimetised. A, Raamat ja aeg, 1736-6984 ; nr. 1) ; (Eesti Rahvusraamatukogu toimetised ; 11)

  12. Kestmine kui probleem / Marju Lauristin

    Index Scriptorium Estoniae

    Lauristin, Marju, 1940-

    1987-01-01

    Vestlus vabariikliku teatrifestivali "Tartu ' 87" žürii liikmega : A. Kitzbergi "Libahunt" Rakvere Teatris, A. H. Tammsaare-A.-E. Kerge "Aeg tulla, aeg minna" Vanemuises, T. Ajtmatovi "Ja sajandist on pikem päev" Ugalas

  13. Poliitika ja poeesia eesti graafikas : Tallinna XIV graafikatriennaal ja "Impact 5" / Andri Ksenofontov

    Index Scriptorium Estoniae

    Ksenofontov, Andri, 1962-

    2007-01-01

    Tallinna XIV graafikatriennaalist "Poliitiline/Poeetiline" ning rahvusvahelisest graafikakonverentsist "Impact 5" teemal "Lõigatud aeg" ja selle raames avatud näitustest (Vappu Thurlowi kureeritud "Lõigatud aeg" Adamson-Ericu muuseumis jpt.)

  14. A SEMIOLOGIC APPROACH TO AUDIT EXPECTATIONS GAP

    Directory of Open Access Journals (Sweden)

    Ciolpan Daniela

    2009-05-01

    Full Text Available Audit expectations gap (AEG is one of the most debated phenomena animating the international scientific research scene. The volume of papers focused on defining the AEG concept, examining its determinants, implications, and mechanisms to minimize the gap

  15. ADVERTORIAL

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    AEG AEG is the world’s leading provider of live entertainment and sports programming. Through acquisitions and intrinsic growth strategies, the company has expanded its businesses to include state-of-the-art venues, major sports properties, live enter-

  16. Knockdown of astrocyte elevated gene-1 inhibits tumor growth and modifies microRNAs expression profiles in human colorectal cancer cells

    Energy Technology Data Exchange (ETDEWEB)

    Huang, Sujun [East Department of Gastroenterology, Institute of Geriatrics, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080 (China); Southern Medical University, Guangzhou, Guangdong 510515 (China); Wu, Binwen, E-mail: wubinwengd@aliyun.com [East Department of Gastroenterology, Institute of Geriatrics, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080 (China); Li, Dongfeng; Zhou, Weihong; Deng, Gang; Zhang, Kaijun; Li, Youjia [East Department of Gastroenterology, Institute of Geriatrics, Guangdong General Hospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510080 (China)

    2014-02-14

    Highlights: • AEG-1 expression in CRC cell lines and down-regulation or upregulation of AEG-1 in vitro. • Knockdown of AEG-1 inhibits cell proliferation, colony formation and invasion. • Upregulation of AEG-1 enhances proliferation, invasion and colony formation. • Knockdown of AEG-1 accumulates G0/G1-phase cells and promotes apoptosis in CRC cells. • AEG-1 knockdown increases 5-FU cytotoxicity. - Abstract: Astrocyte elevated gene-1 (AEG-1), upregulated in various types of malignancies including colorectal cancer (CRC), has been reported to be associated with the carcinogenesis. MicroRNAs (miRNAs) are widely involved in the initiation and progression of cancer. However, the functional significance of AEG-1 and the relationship between AEG-1 and microRNAs in human CRC remains unclear. The aim of this study was to investigate whether AEG-1 could serve as a potential therapeutic target of human CRC and its possible mechanism. We adopted a strategy of ectopic overexpression or RNA interference to upregulate or downregulate expression of AEG-1 in CRC models. Their phenotypic changes were analyzed by Western blot, MTT and transwell matrix penetration assays. MicroRNAs expression profiles were performed using microarray analysis followed by validation using qRT-PCR. Knockdown of AEG-1 could significantly inhibit colon cancer cell proliferation, colony formation, invasion and promotes apoptosis. Conversely, upregulation of AEG-1 could significantly enhance cell proliferation, invasion and reduced apoptisis. AEG-1 directly contributes to resistance to chemotherapeutic drug. Targeted downregulation of AEG-1 might improve the expression of miR-181a-2{sup ∗}, -193b and -193a, and inversely inhibit miR-31 and -9{sup ∗}. Targeted inhibition of AEG-1 can lead to modification of key elemental characteristics, such as miRNAs, which may become a potential effective therapeutic strategy for CRC.

  17. Lentivirus-Mediated Knockdown of Astrocyte Elevated Gene-1 Inhibits Growth and Induces Apoptosis through MAPK Pathways in Human Retinoblastoma Cells.

    Directory of Open Access Journals (Sweden)

    Ying Chang

    Full Text Available To explore expression and function of astrocyte elevated gene-1 (AEG-1 in human retinoblastoma (RB.The expression of AEG-1 in histological sections of human RBs and in RB cell lines was examined using immunohistochemical staining and RT-PCR and Western blotting respectively. We knocked down AEG-1 gene levels by AEG-1-siRNA lentivirus transfection of human RB cell lines SO-RB50 and Y79, and using an MTT assay, we assessed the role of AEG-1 on RB cell proliferation. The biological significance of lentivirus transfection induced AEG-1 down-regulation was examined by assessing the apoptosis rate in the transfected RB cells by Annexin V-APC staining and flow cytometry. We additionally measured the expression of Bcl-2, Bax, cleaved-caspase-3 and caspase-3, and the phosphorylation and non-phosphorylation alternation of MAPKs.AEG-1 expression was detected to be strongly positive in the histological slides of 35 out of 54 (65% patients with RB. AEG-1 expression increased significantly (P<0.05 with tumor stage. In the RB cell lines SO-RB50, Y79 and WERI-RB1 as compared with retinal pigment epithelium cells, expression of AEG-1 mRNA and AEG-1 protein was significantly higher. In AEG-1-siRNA lentivirus transfected cell cultures as compared with negative control lentivirus transfected cell cultures, levels of AEG-1 mRNA and of AEG-1 protein (P<0.05 and cell growth rates (P<0.01 were significantly lower, and apoptosis rate (P<0.001, Bax/Bcl-2 ratio and cleaved-caspase-3 protein level were significantly increased. The P-ERK/ERK ratio was significantly decreased in the AEG-1-siRNA lentivirus transfected cell lines.Expression of AEG-1 was associated with RB, in histological slides of patients and in cell culture experiments. Lentivirus transfection induced knockdown of AEG-1 had a tumor suppressive effect, potentially by tumor cell apoptosis induction through inhibition of ERK.

  18. Ikka teel / Marian Kivila

    Index Scriptorium Estoniae

    Kivila, Marian

    2009-01-01

    Rahvusvahelise tegevuskunstifestivali "Diverse Universe 2009" üritustest Tallinna Kultuurikatlas, Tartu pärmitehases ja galeriis Ferrodrum ning Paides, kus toimus kunstifestval "Aeg. Ruum. Liikumine"

  19. Appi räsitud firmadele. Pohjola: praegu on tulekuks õige aeg / Reima Rytsölä, Arja Jurmu, Jorma Alanne ; intervjueerinud Kadrin Karner ; kommenteerinud Andreas Laane, Hans Pajoma, Robert Kitt

    Index Scriptorium Estoniae

    Rytsölä, Reima

    2011-01-01

    Pohjola pank avas Tallinnas kontori äriklientide teenindamiseks. Küsimustele vastavad Pohjola Groupi pangandusoperatsioonide juht Reima Rytsölä, Pohjola panga Eesti filiaali juht Arja Jurmu ja Pohjola Balti panganduse juht Jorma Alanne

  20. Astrocyte elevated gene-1 regulates CCL3/CCR5-induced epithelial-to-mesenchymal transition via Erk1/2 and Akt signaling in cardiac myxoma.

    Science.gov (United States)

    Shi, Ping; Fang, Changcun; Pang, Xinyan

    2015-09-01

    In recent years, astrocyte elevated gene-1 (AEG-1) has been reported as a key mediator that is involved in the epithelial-to-mesenchymal transition (EMT) process. However, the mechanisms underlying CCL3/CCR5-AEG-1 pathway-mediated EMT in cardiac myxoma (CM) has not been well featured till now. We used immnohistochemistry and immunoblotting to assess the expression of CCR5 and AEG-1 in 30 cases of CM tissues and cells. Subsequently, cultured CM cells were treated with si-AEG-1 or si-CCR5 and then subjected to in vitro assays. We observed that CCR5 and AEG-1 proteins were highly expressed in CM tissues (73.3 and 76.7%, respectively) and closely correlated with tumor size (>5 cm). Importantly, we validated the expression of AEG-1, p-Erk1/2, p-Akt, vimentin, N-cadherin and MMP2 increased in the CM cell with CCL3 treatment in a time- and concentration-dependent manner. When CM cells were treated with si-CCR5, the expression of AEG-1, p-Erk1/2, p-Akt, vimentin, N-cadherin and MMP2 was downregulated. In addition, when CM cells were treated with si-AEG-1, the expression of p-Erk1/2, p-Akt, vimentin, N-cadherin and MMP2 was also downregulated. Using the cell cycle and proliferation assay, the knockdown of AEG-1 inhibited the entry of G1 into S phase and the proliferation capacity of CM cells. In conclusion, AEG-1 mediates CCL3/CCR5-induced EMT development via both Erk1/2 and Akt signaling pathway in CM patients, which indicates CCL3/CCR5-AEG-1-EMT pathway could be suggested as a useful target to affect the progression of CM.

  1. Knockdown of astrocyte elevated gene-1 inhibits proliferation and enhancing chemo-sensitivity to cisplatin or doxorubicin in neuroblastoma cells

    Directory of Open Access Journals (Sweden)

    Xie Li

    2009-02-01

    Full Text Available Abstract Background Astrocyte elevated gene-1 (AEG-1 was originally characterized as a HIV-1-inducible gene in primary human fetal astrocyte. Recent studies highlight a potential role of AEG-1 in promoting tumor progression and metastasis. The aim of this study was to investigate if AEG-1 serves as a potential therapeutic target of human neuroblastoma. Methods We employed RNA interference to reduce AEG-1 expression in human neuroblastoma cell lines and analyzed their phenotypic changes. Results We found that the knockdown of AEG-1 expression in human neuroblastoma cells significantly inhibited cell proliferation and apoptosis. The specific downregulation induced cell arrest in the G0/G1 phase of cell cycle. In the present study, we also observed a significant enhancement of chemo-sensitivity to cisplatin and doxorubicin by knockdown of AEG-1. Conclusion Our study suggests that overexpressed AEG-1 enhance the tumorogenic properties of neuroblastoma cells. The inhibition of AEG-1 expression could be a new adjuvant therapy for neuroblastoma.

  2. Eesti Energia, vara veel! / Väino Sarnet

    Index Scriptorium Estoniae

    Sarnet, Väino, 1952-

    2010-01-01

    Majanduskonsultant avaldab arvamust, millised on argumendid Eesti Energia kiireks börsiletulekuks, kes sellega võidaksid ja kes kaotaksid ning miks pole praegu õige aeg Eesti Energia aktsiate avalikuks müügiks

  3. How Long is the SLAC Gallery?

    Energy Technology Data Exchange (ETDEWEB)

    Imfeld, Hans; /SLAC

    2007-08-24

    How long is the gallery? Since the two methods of observation have similar accuracy and in the interest of keeping it simple, AEG averaged the two methods and determined that the length of the Gallery is 3073.72m.

  4. Jah, tõesti, nii - ja mis siis? / Karlo Funk

    Index Scriptorium Estoniae

    Funk, Karlo, 1971-

    2000-01-01

    Mõtteid Eesti filmide nädalast Kinomajas ja seal näidatud Eestis 1999.aastal valminud filmidest, lähemalt Heini Drui dokumentaalfilmist "Tulekummardajad" ja Dorian Supini dokumentaalfilmist "Armastuse aeg"

  5. Muusika / Priit Kuusk

    Index Scriptorium Estoniae

    Kuusk, Priit, 1938-

    2005-01-01

    Muusikasündmustest Eestis: Improvizz'05, Jazz'n Motion, muusikafestivali "Eduard Tubin ja tema aeg" pressikonverents, laulumäng "Suur Munamägi" Estonia kammersaalis, modernismi pidunädal Tartu Elleri koolis

  6. Parliamentarians call for resignation of Finance Minister / Monika Hanley

    Index Scriptorium Estoniae

    Hanley, Monika

    2008-01-01

    Opositsiooni kuuluv erakond Uus Aeg leiab, et Läti rahandusminister Atis Slakteris peaks ebakompetentsuse tõttu tagasi astuma. Poliitikute arvates, ei ole Slakteris piisavalt aktiivselt püüdnud riigi finantsprobleeme lahendada

  7. Estonia plans to build nuclear power plant / Jana Belugina

    Index Scriptorium Estoniae

    Belugina, Jana

    2009-01-01

    Eesti Energia on tuumaelektrijaama ehitamiseks välja valinud kuus asukohta. Seadusandlikke otsuseid tuumaelektrijaama ehitamise kohta saab vastu võtta alates 2014. aastast ning tuumareaktori valmimise aeg on 2025. aasta

  8. Kreisid ideed nõuavad pidevalt lisa / Mihkel Truman ; intervjueerinud Kadri Haavajõe

    Index Scriptorium Estoniae

    Truman, Mihkel

    2009-01-01

    Intervjuu novembri alguses 2008 Rakvere linna kultuuriosakonna juhataja kohale asunud Mihkel Trumaniga kultuurielust Rakveres, ansambli Rock-Hotel 30. juubeliks ilmunud raamatust "Aeg meid muutnud on", mille autoriks on intervjueeritav ning ajakirjast "Värske Rõhk", mille kolleegiumisse ta kuulub

  9. Adamkus : EU might be willing to negotiate on postponing Ignalina reactor closure

    Index Scriptorium Estoniae

    2008-01-01

    President Valdas Adamkus teatas võimalusest, et EL alustab arutelu Ignalina tuumaelektrijaama sulgemise edasilükkamisest. Uue jaama valmimise aeg pole teada ning praegune reaktor on tänu rootslaste abile turvaline

  10. USA-s jagati kirjandusauhindu / Kaarel Kressa

    Index Scriptorium Estoniae

    Kressa, Kaarel, 1983-

    2007-01-01

    Ameerika Ühendriikide kirjandusauhinna National Book Award laureaadid 2007. a.: parim prosaist - Denis Johnson (romaan "Suitsupuu"), parim noorsookirjanik - Sherman Alexie ("Poole kohaga indiaanlase absoluutselt tõene päevik"), parim luuletaja - Robert Hass (luulekogu "Aeg ja ained")

  11. USA maksumaksja nuriseb HIV-ennetusraha kulutamise üle / Anti Liiv

    Index Scriptorium Estoniae

    Liiv, Anti, 1946-

    2004-01-01

    Henry J. Kaiseri perekonna sihtasutus uuris tänavu, kuidas on USA maksumaksjad rahul nende raha kinkimisega välisriikidele HIV-vastaseks võitluseks. Autori arvates oleks ka Eestis aeg selliseid uuringuid korraldada

  12. Territoriaalplaneerimise õiguslik regulatsioon Eesti Vabariigis : [bakalaureusetöö] / Andrus Kattel ; Tartu Ülikool, õigusteaduskond ; juhendaja: Sirje Tael

    Index Scriptorium Estoniae

    Kattel, Andrus

    1998-01-01

    Kaasaegse territoriaalplaneerimise kujunemine, Eesti Vabariigi 1939. a. ehitusseadus, nõukogude aeg, üleminekuperiood 1989-1995, 1995. a. planeerimis- ja ehitusseadus (selle asend Eesti õigussüsteemis, kohalike omavalitsuste õigused ja kohustused, mõju maakasutusele)

  13. Birgit Õigemeele jõulualbumi eelesitlus

    Index Scriptorium Estoniae

    2008-01-01

    Rõivabränd Pepe Jeans London korraldab Tallinnas Kristiine keskuses Birgit Õigemeele minikontserdi ja jõulualbumi "Ilus Aeg" plaadiesitluse (heliplaadil teevad kaasa ka Uku Suviste ja ETV lastekoor Lii Leitmaa juhatusel)

  14. Mähkmetest igaviku läveni / Aarne Ruben

    Index Scriptorium Estoniae

    Ruben, Aarne, 1971-

    2008-01-01

    Urmas Eero Liivi dokumentaalfilm "Tervitusi Nõukogude Eestist!" vabadusvõitlejatest Lagle Parekist, Tunne Kelamist ja Tiit Madissonist : RUUT, 2007. Katrin Lauri dokumentaalfilm luuletaja Debora Vaarandist "Debora Vaarandi aeg" : Content Provider 2007

  15. Suvemuusika / Igor Garshnek

    Index Scriptorium Estoniae

    Garšnek, Igor, 1958-

    1999-01-01

    Händeli oratooriumi "Iisrael Egiptuses" ettekandest Tallinna toomkirikus 18. juulil. Trio Leibur-Terasmaa-Mätlik kontserdist "Tangokuningas Astor Piazolla" 20. juulil Mustpeade Majas. Kontserdisarja "Rootsi aeg 1998-1999" lõppkontserdist Estonia kontserdisaalis 27. juulil

  16. Investor interest returning as economies start to stabilize

    Index Scriptorium Estoniae

    2009-01-01

    Praegu on õige aeg Baltimaadesse investeerimiseks, kuna ka sealne majandus on stabiliseerumas. Võimalik, et Baltimaade valitsused müüvad veel riigivara. East Capital Groupi osalused Baltimaade ettevõtetes

  17. Hea nali võib peituda raamatus / Gert Kiiler

    Index Scriptorium Estoniae

    Kiiler, Gert

    2007-01-01

    Arvustus: Leer, Jaak. Savumees Einaril on kogu aeg buss katki. Tallinn : Jutulind, 2006 ; Huber, Markus, Treichler, Robert. Keegi pole nii vinge kui meie : uimased britid, tobedad sakslased, pinges prantslased ja veel 36 lootusetut juhtumit. Tallinn : Olion, 2006

  18. Muinasjutt ökokatastroofist / Ilona Martson

    Index Scriptorium Estoniae

    Martson, Ilona, 1970-

    2002-01-01

    Tallinnas ja Tartus tuli ekraanile USA joonisfilm "Jääaeg" ("Ice Age"), mille dubleerimisse on režissöör Janno Põldma juhtimisel kaasatud head eesti näitlejad Anu Lamp, Lembit Ulfsak ja Marko Matvere

  19. Õigemeel ja Suviste toovad jõulumeeleolu / Birgit Õigemeel ; intervjueerinud Keidi Niitsoo

    Index Scriptorium Estoniae

    Õigemeel, Birgit, 1988-

    2008-01-01

    Küsimustele vastavad heliplaadi "Ilus aeg" jõulutuuril esinevad Birgit Õigemeel ja Uku Suviste (jõulualbumi esitluskontserdid on 10.-12. dets. Hageri kirikus, Tartus Jaani kirikus ja Tallinnas Jaani kirikus)

  20. Paul Varul : Eesti vajab presidendi seadust / Paul Varul ; interv. Toomas Sildam

    Index Scriptorium Estoniae

    Varul, Paul, 1952-

    2000-01-01

    Poliitikutel on harjumus teha aeg-ajalt seaduseväliseid otsuseid - Johannes Kerdi vabastamine kaitseväe juhataja ametist. Arvamused: Lennart Meri, Liia Hänni ja Tiit Tammsaar. Parlamendisaadik (L. Hänni, T. Tammsaar)

  1. Ajamere lainetes / Jana Savi

    Index Scriptorium Estoniae

    Savi, Jana

    2012-01-01

    Psühholoogilisest aja käsitlusest - minevik, olevik, tulevik ning teraapiatest (elu)probleemide lahendamiseks. Hetkes elamisest ning neljandast mõõtmest (aeg ja ruum), aegruumi mustritest ja maiade kalendrist

  2. Geneetiliselt muundatud? / Epp Petrone

    Index Scriptorium Estoniae

    Petrone, Epp, 1974-

    2006-01-01

    Ameerikas on geneetiliselt muundatud toitu kasvatatud 20 ja ulatuslikult toodetud kaheksa aastat, ning juba mõni aeg tagasi kadus kontroll selle üle, mis supermarketites müüdavast tavatoidust on GMO-vaba ja mis mitte

  3. New Era stands against Muiznieks / Aaron Eglitis

    Index Scriptorium Estoniae

    Eglitis, Aaron

    2005-01-01

    Läti juhtiv parempartei Uus Aeg ning rahvuslikud Isamaa Eest ja Vabadus ei toeta koalitsiooni kuuluva Läti Esimese Partei liikme Nils Muiznieksi kandidatuuri inimõiguste osakonna juhiks kuna viimane olevat ebakompetentne ja eelarvamustega

  4. Tegevuskunstnikud üllatavad balliga / Eero Ijavoinen ; interv. Arnika Tegelmann

    Index Scriptorium Estoniae

    Ijavoinen, Eero, 1963-

    2000-01-01

    Intervjuu tegevuskunstifestivali "Aeg Ruum Liikumine" korraldaja Eero Ijavoineniga; festivalil osalevad Leonhard Lapin, Ilmar Kruusamäe, Kaarina Ormio, Roi Vaara, David Rotenberg, Jaanika Peerna, Gert Hatsukov, vene rühmitus The Blind

  5. Proshtshai, dollar? / Kenneth Rogoff ; tõlk. Irina Sashtshenkova

    Index Scriptorium Estoniae

    Rogoff, Kenneth

    2008-01-01

    Autor kirjutab dollari nõrgenemisest ja selle alternatiividest rahvusvahelisel valuutaturul ning euro tugevnemisest. Pankurid ja rahandustegelased peaksid hakkama mõtlema, mida teha siis, kui on aeg dollari toetamine lõpetada

  6. "Impact 4" Berliinis ja Poznanis / Vappu Thurlow

    Index Scriptorium Estoniae

    Thurlow, Vappu, 1960-

    2005-01-01

    5.-10. IX Berliinis ja Poznanis toimunud neljandast rahvusvahelisest graafikakonverentsist "Impact" alapealkirjaga "Kontakt". Eestist osalesid Loit Jõekalda, Eve Kask, Karin Laansoo ja Vappu Thurlow. 2007. a. Tallinnas toimuva "Impact 5", alapealkirjaga "Slices of Time/Lõigutud aeg", kontseptsioon

  7. Master Minimum Equipment List

    Data.gov (United States)

    Department of Transportation — The AEG System is used to create, revise, approve, and distribute text of the MMEL and Flight Standard Board (FSB)/Type Rating Report. The MMEL specifies under what...

  8. Novellivõistlus jäi ilma võiduta, aga sõelale jäid mõistujutud ajast / Valner Valme

    Index Scriptorium Estoniae

    Valme, Valner, 1970-

    2005-01-01

    EKLi korraldatud 2005. a. novellivõistluse preemiad: Aivar Jürgenson. Lambakarjus ja aeg (II koht), Toomas Raudam. Vesi (II koht), ergutusauhinnad: Angela Hofberg (pseud.). Väljapääs, Leonhard Koort (pseud.). Kenzo lilled

  9. Kätepesu võib nakkustest päästa / Ada Maltseva

    Index Scriptorium Estoniae

    Maltseva, Ada, 1970-

    2006-01-01

    Vt. ka Linnaleht : Tartu 5. mai, lk. A8-A9 ; Linnaleht : Tallinn : na russkom jazõke 12. apr. Haigusi saab vältida nii vaktsineerimise kui ka elementaarse puhtuse hoidmisega. Lisa: Viimane aeg puugisüstiks

  10. Õigusterminid ja õigusharidus, erialase oskussõnavara omandamine / Merike Ristikivi

    Index Scriptorium Estoniae

    Ristikivi, Merike, 1973-

    2012-01-01

    Juristide jaoks olulise erialase oskussõnavara omandamisest kolmel perioodil: 1918-1940, nõukogude aeg ning taasiseseisvusaeg. Õigusterminoloogia omandamisest ning õppevahenditest, mille alusel ülikoolis juriidilisi termineid õpetati ja õpiti

  11. Pop / Tõnu Pedaru

    Index Scriptorium Estoniae

    Pedaru, Tõnu

    2007-01-01

    Heliplaatidest: Ska Factor "Aeg on uus", M83 "Digital Shades. Vol 1", Keyshia Cole "Just Like You", Scandinavian Music Group "Missä Olet Laila?", Mick Jagger "The very best of Mick Jagger", Dave Gahan "Hourglass"

  12. Saksa vastupanu ja prantsuse tundeelu / Endel Link

    Index Scriptorium Estoniae

    Link, Endel

    2005-01-01

    Berliini 55. filmifestivalist ja festivali filmidest : sakslase Marc Rothemundi "Sophie Scholl - viimased päevad", prantslase Régis Wargineri "Man to Man" ja teise prantslase André Téchiné "Muutunud aeg"

  13. Hetk enne plahvatust : arhitektuuri tulevik / Alberto Campo Baeza

    Index Scriptorium Estoniae

    Campo Baeza, Alberto

    1997-01-01

    Teemad: Arhitektuuri tulevik on ideedes. Valgus ja gravitatsioon : küsimuse olemus. Inimene ja tabatud ilu. Aeg ja arhitektuur. Projektiliialdused ja tehnoloogia ebaadekvaatne rakendamine. Ühiskond ja kunstnik.

  14. Raamatureisid Veneetsiasse / Margus Haav

    Index Scriptorium Estoniae

    Haav, Margus, 1969-

    2005-01-01

    Arvustus: Girardi, Robert. Vaporetto 13 / ingl. k. tlk. Karin Suursalu. Tallinn : Kultuurileht, 2005. (Loomingu Raamatukogu) ; Raittila, Hannu. Canal Grande : [romaan] / tõlkinud Aivo Lõhmus. Tallinn : Varrak, 2003 (Moodne aeg)

  15. 3 vahvat / Margit Kilumets, Mari Öö Sarv

    Index Scriptorium Estoniae

    Kilumets, Margit, 1964-

    2014-01-01

    Aivo Lillest, kes on kandnud hoolt kvaliteetsete jalgrattateede rajamise eest Kalamajas; Laura Tederist, kelle hoole all on aeg-ajalt ühe perekonna viis last, ning Tambet Talist ja Kaisa Üprus-Talist, kes tegelevad leinalaagrites lastega

  16. Euro kasutuselevõtuks ametnikel töö tehtud / Piret Reiljan

    Index Scriptorium Estoniae

    Reiljan, Piret, 1983-

    2007-01-01

    Eesti eurole üleminekut ette valmistanud ametnike koostatud infomaterjalid ja tegevuskavad on valmis, ent euro saabumise aeg pole veel teada. Diagramm: Inflatsioonimäär. Kommenteerivad Jan Linden ja Klas Eklund

  17. Astrocyte elevated gene-1 induces breast cancer proliferation and invasion through upregulating HER2/neu expression

    Institute of Scientific and Technical Information of China (English)

    ZHANG Xin; ZHANG Ning; ZHANG Mei-xin

    2011-01-01

    Background Astrocyte elevated gene-1 (AEG-1),primarily identified as a late response gene induced by HIV-1 infection,plays multiple roles in the process of oncogenesis.This novel gene has been demonstrated to be involved in the several potent carcinogenic pathways,including PI3K/Akt pathway,nuclear factor (NF)-KB pathway,and Wnt/β-catenin pathway.Although the function of AEG-1 has been intensively investigated in recent years,the molecular mechanism underlying its oncogenic role is largely unknown.The aim of this research was to explore the potential function of AEG-1 in breast cancer development and progression.Methods AEG-1 was ectopically overexpressed in breast cancer MCF-7 cells and its biological effects on the proliferation and invasion of MCF-7 cells were studied by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and invasion assays.The expression of HER2/neu,a crucial oncogene involving in breast cancer carcinogenesis,was also determined.Results Overexpression of the AEG-1 promoted the proliferation and invasion ability of breast cancer cells,and upregulated the expression of HER2/neu,a crucial oncogene involving in breast cancer carcinogenesis.Conclusion AEG-1 might facilitate the proliferation and invasion of breast cancer cells by upregulating HER2/neu expression,which provides a potential target for breast cancer therapy.

  18. Expression and functional characterization of two pathogenesis-related protein 10 genes from Zea mays.

    Science.gov (United States)

    Xie, Yu-Rong; Chen, Zhi-Yuan; Brown, Robert L; Bhatnagar, Deepak

    2010-01-15

    A novel PR10 gene (ZmPR10.1) was isolated from maize and its expression and function were compared with the previous ZmPR10. ZmPR10.1 shares 89.8% and 85.7% identity to ZmPR10 at the nucleotide and amino acid sequence level, respectively. ZmPR10 and ZmPR10.1 were mainly expressed in root tissue with low expression in other tissues. ZmPR10.1 had significantly lower expression than ZmPR10 in all tissues examined. The expression of both ZmPR10 and ZmPR10.1 was induced by most abiotic stresses including SA, CuCl(2), H(2)O(2), coldness, darkness and wounding during the 16-h treatments, and biotic stresses such as Erwinia stewartii and Aspergillus flavus infection. However, ZmPR10.1 was induced only 2 HAT and down-regulated thereafter, whereas ZmPR10 remained induced during the 16-h NAA treatment. Also, inoculation with Erwinia chrysanthemi caused about 2-fold induction in ZmPR10.1 expression 60 HAT but not significant changes for ZmPR10. Both ZmPR10.1 and ZmPR10 showed RNase activity in vitro with an optimal pH and temperature of 6.5 and 55 degrees C. Their RNase activities were significantly inhibited by low concentrations (1.0mM) of Cu(2+), Ag(+), Co(2+), SDS, EDTA or DTT. However, ZmPR10.1 possessed significantly higher (8-fold) specific RNase activity than ZmPR10. Also, ZmPR10.1 showed a stronger inhibition against bacterium Pseudomonas syringae pv. tomato DC3000 in vivo and fungus A. flavus in vitro than ZmPR10, indicating that ZmPR10.1 may also play an important role in host plant defense.

  19. 75 FR 45108 - Enterprise Alabama Intrastate, LLC Yankee Gas Services Company Kinder Morgan Tejas Pipeline LLC...

    Science.gov (United States)

    2010-08-02

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR10-63-000; Docket No. PR10-64-000; Docket No. PR10-66- 000] Enterprise Alabama Intrastate, LLC Yankee Gas Services Company Kinder Morgan Tejas Pipeline LLC...

  20. The benefits of a high-intensity aquatic exercise program (HydrOS) for bone metabolism and bone mass of postmenopausal women.

    Science.gov (United States)

    Moreira, Linda Denise Fernandes; Fronza, Fernanda Cerveira A O; Dos Santos, Rodrigo Nolasco; Zach, Patrícia Lins; Kunii, Ilda S; Hayashi, Lilian Fukusima; Teixeira, Luzimar Raimundo; Kruel, Luis Fernando Martins; Castro, Marise Lazaretti

    2014-07-01

    This study aimed to evaluate the 24-week effects of a high-intensity aquatic exercise program on bone remodeling markers and bone mass of postmenopausal women. In this randomized, controlled trial we studied 108 women (58.8 ± 6.4 years), randomized into Aquatic Exercise Group (AEG), n = 64, performing 24 weeks of aquatic exercises, and Control Group (CG), n = 44, sedentary. They had their fasting morning blood sample collected for the measures of intact parathyroid hormone (iPTH), procollagen type 1 amino-terminal propeptide (P1NP) and carboxy-terminal cross-linking telopeptide of type I collagen (CTx). Bone mass was measured by dual-energy X-ray absorptiometry before and after the intervention. Participants of both groups received a daily supplementation of 500 mg of elementary calcium and 1,000 IU of vitamin D (cholecalciferol). Results showed an augment in bone formation marker (P1NP) only in the AEG (15.8 %; p = 0.001), and although both groups experienced significant enhancements in bone resorption marker (CTx), this increase was less considerable in the AEG (15 % in the AEG and 29 % in the CG). IPTH was increased by 19 % in the CG (p = 0.003) at the end. The femoral trochanter BMD presented a 1.2 % reduction in the CG (p = 0.009), whereas in the AEG no change was observed (p = 0.069). The proposed aquatic exercise program was efficient in attenuating bone resorption raise and enhancing bone formation, which prevented the participants in the AEG from reducing the femoral trochanter BMD, as happened in the CG.

  1. Geant4 Simulation of Annihilation and excitation of Positronium

    CERN Document Server

    Gad, Andreas

    2016-01-01

    The purpose of this report is to document the work done during the summer of 2016 (18/6- 26/8) as a part of the CERN Summer Student Programme. The work has been done at the AEgIS (Antihydrogen Experiment: Gravity, Interferometry, Spectroscopy) collaboration under the supervision of Lillian Smestad and Michael Doser. The goal of the project was to create a Monte Carlo simulation in Geant4, of Positronium annihilation and excitation in the positron test chamber of the AEgIs experiment.

  2. Arterial Stiffness by Aerobic Exercise Is Related with Aerobic Capacity, Physical Activity Energy Expenditure and Total Fat but not with Insulin Sensitivity in Obese Female Patients with Type 2 Diabetes

    OpenAIRE

    Ji Yeon Jung; Kyung Wan Min; Hee Jung Ahn; Hwi Ryun Kwon; Jae Hyuk Lee; Kang Seo Park; Kyung Ah Han

    2014-01-01

    Background Arterial stiffness is an important factor in atherosclerosis. Thus we examined whether aerobic exercise could reduce arterial stiffness in obese women with type 2 diabetes without diabetic complication. Methods A total of 35 women with type 2 diabetes (body mass index, 26.6±2.8 kg/m2; age, 56.4±1.9 years; duration of diabetes, 4.7±4.8 years) were assigned to aerobic exercise group (AEG) or control group (CG). AEG completed a 12-week exercise program (3.6 to 5.2 metabolic equivalent...

  3. Päästke mööbel! / Marko Rillo

    Index Scriptorium Estoniae

    Rillo, Marko

    2006-01-01

    Näide üle-eestilise juhtimiskonkursi "Juhtimisaju 2006" ühest ülesandest ning võistkonna "Mõistuse hääl" probleemilahendus. Lisa: Ülesanne; Vt. samas: Kas tankis põlenud poiste aeg pole mitte läbi? Lisa: Teinto Furniture'i SWOT analüüs

  4. Värdjatest, kui mitte muust / Karlo Funk

    Index Scriptorium Estoniae

    Funk, Karlo, 1971-

    1999-01-01

    Mängufilmid "Tantsija aeg" ("Vremja tantsora") : Stsenarist Aleksandr Mindadze : režissöör Vadim Abdrashitov : Venemaa 1997 ja "Värdjatest ja inimestest" ("Pro urodov i ljudei") : Stsenarist ja režissöör Aleksei Balabanov : Venemaa - Ameerika Ühendriigid 1998

  5. Kuhu kadus kurikuulus KGB märkmik? / Tiina Kaalep

    Index Scriptorium Estoniae

    Kaalep, Tiina, 1964-

    2005-01-01

    1993. a. ilmus ajalehes Eesti Aeg väidetavate KGB kaastöötajate nimed, ülevaade nimekirja avaldamisele järgnenust. Nimekirja sisaldanud märkmiku asukoht on praeguseks teadmata. Vt. samas intervjuud Tartu KGB viimase juhi Anti Taluriga

  6. USA hiiglane GE Healthcare korraldab meditsiinis revolutsiooni / Andrew Jack

    Index Scriptorium Estoniae

    Jack, Andrew

    2006-01-01

    General Electricu tütarettevõte GE Healthcare võttis üle Briti diagnostika- ja bioteaduse uurimisfirma Amersham, firma strateegia tuum on võimsa skaneerimistehnoloogia ja meditsiinilise diagnostika üksteisele lähendamine. Lisa: Aeg sorteerida andmeid infotehnoloogia abil

  7. Romaanid võistu rebimas - August Jakobsonist Sass Hennoni / Jaak Urmet

    Index Scriptorium Estoniae

    Urmet, Jaak, 1979-

    2005-01-01

    2004. a. romaanivõistluse esikoharomaan on Sass Henno "Mina olin siin", teine koht: Olavi Ruitlane "Kaval-Peeter ja Vene-Pagan", kolmas koht: Meelis Friedenthal "Kuldne aeg". Sisaldab võitjate nimekirja 1979-2004 ja andmeid noorte silmapaistvate autorite kohta: Kaarel Kressa, Toomas Verrev, Priit Kruus, Rolf Liiv, André Trinity, Jana Lepik,

  8. Novaja jadernaja ugroza / Louis-Rene Beres

    Index Scriptorium Estoniae

    Beres, Louis-Rene

    2007-01-01

    Tänapäeval võib terroristide käsutuses olla nii tuumarelv kui ka teisi massihävitusrelvi ning sellest tingituna on vaja ka uut julgeolekustrateegiat. On tulnud aeg välja töötada kaasaegne Manhattani projekti analoog

  9. ERGO Jazz Session võõrustab Chris Gall Triot. Vennad Urbid ajakohaste lauludega

    Index Scriptorium Estoniae

    2008-01-01

    14. septembril alustab Jazzkaar koostöös ERGO Kindlustusega uut sarja ERGO Jazz Session, mille avaesinejaks on Chris Gall Trio (kontserdid 14. sept.Kumu auditooriumis ja 15. sept. Tartus Athena keskuses). Vendade Urbide kontserdist "Aeg" 13. sept. Vanemuise kontserdimajas

  10. Fotod Michel Sittowi loomingust

    Index Scriptorium Estoniae

    2001-01-01

    Nigulistes Michel Sittowi 475. surma-aastapäevale pühendatud õppeotstarbeline reprofotode näitus kunstniku loomingust. Koostaja Helena Risthein, kujundaja Liina Siib, fotod - Stanislav Stepashko. 20. I teabepäev ajaloo- ja kunstiõpetajatele "Michel Sittow ja tema aeg". Kava vt. lk. 22. Kunstnikust.

  11. Mind häirib edukultus. Mind häirib progressikultus. Mind kohutavalt häirib laristamine ja raiskamine / Enn Soosaar ; interv. Urmo Soonvald

    Index Scriptorium Estoniae

    Soosaar, Enn, 1937-2010

    2007-01-01

    Tõlkija, esseist ja kolumnist räägib poliitikast, Eesti ühiskonnast, Eesti suhetest Venemaaga, oma kokkupuudetest presidentide Lennart Meri, Arnold Rüütli ja Toomas Hendrik Ilvesega. Vt. samas: President Ilves tsiteerib 24. veebruaril 2007 Soosaart. Vabariigi aastapäeva kõnes tsiteeris president T. H. Ilves E. Soosaare raamatut "Isa ja Aeg"

  12. Kunstnike uus põlvkond Kumus / Ragne Nukk

    Index Scriptorium Estoniae

    Nukk, Ragne

    2008-01-01

    Eesti Kunstiakadeemia vabade kunstide osakonna magistrantide lõputööde näitusest Kumu kunstimuuseumis. Pikemalt kunstnikeduo Johnson&Johnson dokumentatsioonist, Marge Monko fotoseeriast "Uurimusi kodanlusest", Leen Võrno tööst "Aeg/koht, ajatus/kohatus", mis on kujundus lühifilmile. Näituse kuraator Maarin Ektermann

  13. Maadeuurijad = Landkönnu̧irnir : [luuletused] / Bragi Ólafsson ; tlk. Arvo Alas

    Index Scriptorium Estoniae

    Ólafsson, Bragi

    2004-01-01

    Sisu: Maadeuurijad = Landkönnu̧irnir; Hiilgav ehituskunst = Glجstar SmÍ̧ar; Aeg ise = Sj{u00E1lfur tÍminn; Kilud = Ansj̤sur; Raamitud maja = Innan ramma h{250}ssins; Hilissuvisel ajal = ℓ sÍşumarsdögum

  14. Töötuskindlustushüvitise suurus ületab kindlustusmaksed mitmekordselt / Anne Lauringson

    Index Scriptorium Estoniae

    Lauringson, Anne

    2008-01-01

    Ilmunud ka: Narvskaja Gazeta : Töötukassa 27. märts lk. 4, Den za Dnjom : Töötukassa 28. märts lk. 4. Töötuskindlustushüvitise eesmärgist ja saamise võimalustest. Diagramm: Hüvitise saamise aeg kuudes

  15. Rohelisest linnast : haljas linn / Ignar Fjuk

    Index Scriptorium Estoniae

    Fjuk, Ignar, 1953-

    2006-01-01

    Linnahaljastusest Eestis, haljastuse tähtsusest linnaplaneerimises, ajaloost ja tänapäevast. Näiteks toodud Tallinna vanalinna Harju t. äärde kavandatav haljasala, mis eeldaks projektivõistlust, Kadrioru pargi alumises aias elujõuliste puude hävitamise kava jm. Autori arvates oleks aeg haklata rajama 21 sajandi parke

  16. Prantsusmaa silub Ida-Euroopga suhteid / Riina Luik

    Index Scriptorium Estoniae

    Luik, Riina, 1962-

    2004-01-01

    Prantsusmaa peaminister Jean-Pierre Raffarin kohtus Pariisis Ida-Euroopa ajakirjanikega ja rääkis EL-i riikide suhetest ja majanduskoostööst. Vt. samas: Andres Kasekamp. Näpuga viibutamise aeg on möödas. Lisa: Jean-Pierre Raffarin (55)

  17. [Raamatud] / Teet Korsten

    Index Scriptorium Estoniae

    Korsten, Teet, 1967-

    2006-01-01

    Tutvustus: Murakami, Haruki. Norra mets : romaan / jaapani keelest tõlkinud Kati Lindström. Tallinn : Varrak, 2006. (Moodne aeg) ; Naised on nii imelised : [luulekogumik / koostanud ja järelsõna kirjutanud Jaak Urmet. Tallinn] : Tänapäev, 2006

  18. Stenbocki maja õues kuuleb põnevaid kodumaiseid artiste

    Index Scriptorium Estoniae

    2008-01-01

    Stenbocki maja õuemuusika kontserdisarja kontsertidest: 18. juunil esinevad Rein Rannap ja Tiit Kikas, 2. juulil kontsert "Jazz Emotion" (Sofia Rubina), 16. juulil eesti-ukraina folkansambel Svjata Vatra, juuli eelviimasel nädalal kontsert "Tshellopalavik" (C-Jam ja Kaire Vilgats), augustis kontsert "Hea-tuju-laulud" (Revalia kammermeeskoor), 20. aug. kontsert "Aeg ei peata" (esitusel Ott Arderi sõnadele loodud laulud)

  19. Kill a brand, keep a customer / Nirmalya Kumar

    Index Scriptorium Estoniae

    Kumar, Nirmalya

    2004-01-01

    Autori hinnangul peaksid kõik ettevõtted kasumi suurendamiseks aeg-ajalt oma brändiportfelle optimeerima. Brändide hindamisest, liitmisest, müümisest, kasvatamisest ja kaotamisest. Tabel: The brand audit sheet. Lisa: Do you have too many brands?

  20. Euroopa põllumehed ei taha muutusi

    Index Scriptorium Estoniae

    2008-01-01

    Euroopa põllumajandusühistuid koondava ühenduse COGECA ja Euroopa põllumeeste suurima esindusorganisatsiooni COPA seisukoht on, et praegu ei ole õige aeg võtta Euroopa põllumehelt tootmiseks ette nähtud toetust ning suunata see ümber maaelu arenguks

  1. O sudbe "Estonii" sprosite Laara / Max Kaur

    Index Scriptorium Estoniae

    Kaur, Max, 1969-

    2007-01-01

    Autor leiab, et on tulnud aeg, mil Estonia laevahuku asjus peaksid Mart Laar ja teised Eesti tolleaegsed juhid andma ausaid ja avameelseid tunnistusi; Estonia huku uurimiseks tuleks luua EL-i ja NATO egiidi all uus uurimisrühm, kus peale Eesti, Rootsi ja Soome esindajate oleksid ka Venemaa esindajad

  2. 78 FR 34935 - Revisions to Operational Requirements for the Use of Enhanced Flight Vision Systems (EFVS) and to...

    Science.gov (United States)

    2013-06-11

    ... commerce and national security. List of Abbreviations and Acronyms Frequently Used In This Document AEG... that Significantly Affect Energy Supply, Distribution, or Use VI. Additional Information A. Comments... require recent flight experience or a proficiency check for a person conducting an EFVS operation...

  3. Uus kunstikool näitab oma nägu ja hambaid / Karen Jagodin

    Index Scriptorium Estoniae

    Jagodin, Karen, 1982-

    2004-01-01

    Positivistliku Kunsttööstuskooli kampaaniapäevad algasid Performance Week'iga Ku galeriis. Avamisel esines Mari Sobolev performance'iga "Lost in the system". Kampaaniapäevad kulmineeruvad Paide tegevuskunstifestivaliga "Aeg. Ruum. Liikumine: unplugged". Festivali kuraator on Mari Sobolev

  4. Vtoroje dõhanije / Galina Balashova

    Index Scriptorium Estoniae

    Balashova, Galina

    2001-01-01

    Ehtekunstnik Jaan Pärna projektist Meistrite hoov. Dolomiidi kasutamist kunstis kajastavast näitusest "Pae aeg" Meistrite hoovi galeriis. Kujundas Urve Küttner. Jaan Pärna, Urve Küttneri, Andrei Balashovi ja Helmet Raja töödest näitusel

  5. AcEST: BP913198 [AcEST

    Lifescience Database Archive (English)

    Full Text Available og 1 OS=Aedes aeg... 48 2e-05 sp|Q9H4E7|DEFI6_HUMAN Differentially expressed in FDCP 6 homolog... 48 2e-05 s...47 4e-05 sp|Q8C2K1|DEFI6_MOUSE Differentially expressed in FDCP 6 OS=Mus ... 47 5

  6. Alates 26. VI toimuvad Tallinna Kunstihoone galeriis... / Reiu Tüür

    Index Scriptorium Estoniae

    Tüür, Reiu

    2004-01-01

    Johann Köleri nimelise Positivistliku Kunsttööstuskooli kampaaniapäevad, mis päädivad 10. VII performance'iga Paide keskväljakul tegevuskunstifestivalina "Aeg. Ruum. Liikumine: unplugged" . Kampaaniapäevade kava 2.-10. VII

  7. E-citizen in an E-state / Tarmo Loodus

    Index Scriptorium Estoniae

    Loodus, Tarmo, 1958-

    2001-01-01

    Kaanel ajak. ilmumis aeg Winter 2001/2002. Eesti peab muutuma riigiks, kus avaliku sektori asjaajamine toimub ööpäevaringselt, Interneti-ühendus koduarvuteis on tavaline, kasutusele võetakse digitaalallkiri - kõik see nõuab lisaks tehnoloogia arengule ka organisatoorseid ümberkorraldusi. Autor: Isamaaliit

  8. Milleks on vaja (koledat) kirjandust? / Kurt, pseud Moor, pseud.

    Index Scriptorium Estoniae

    Moor, Kurt, pseud

    2004-01-01

    Sari "Moodne aeg" kirjanduslike kolmapäevade raames (toimus 27. okt. 2004). Tutvustati Bret Easton Ellise "Ameerika psühhopaati" (Jaanus Adamson), Ian McEwani "Tsementaeda" (Ene-Reet Soovik) ja Martin Amise loomingut (Valle-Sten Maiste)

  9. Eesti näitlejad andsid hääle laiskloomale, mammutile ja tiigrile / Ilona Martson

    Index Scriptorium Estoniae

    Martson, Ilona, 1970-

    2002-01-01

    Neljapäeval Tallinnas kobarkinos ekraanile tuleva USA joonisfilmi "Jääaeg" ("Ice Age") dubleerimisse on režissöör Janno Põldma juhtimisel kaasatud parimad eesti näitlejad. J. Põldma filmist ja selle dubleerimisega kaasnenud seikadest

  10. Jah-sõna Hollywoodist paneb aluse kiiduväärt tavale / Anneli Aasmäe

    Index Scriptorium Estoniae

    Aasmäe, Anneli, 1973-

    2002-01-01

    Tallinnas ja Tartus tuli ekraanile USA joonisfilm "Jääaeg" ("Ice Age"), mille dubleerimisse on režissöör Janno Põldma juhtimisel kaasatud parimad eesti näitlejad. Tallinna kobarkino pressiesindaja Lauri Kaare väidab, et see dublaazh ei jää viimaseks

  11. Kolm jääaegset triumfi / Peep Pedmanson

    Index Scriptorium Estoniae

    Pedmanson, Peep

    2002-01-01

    Tallinnas ja Tartus tuli ekraanile USA joonisfilm "Jääaeg" ("Ice Age"), mille dubleerimisse on režissöör Janno Põldma juhtimisel kaasatud parimad eesti näitlejad. Eriti Anu Lambi meisterlikkusest laisklooma dubleerimisel ning arvutianimatsiooni kõrgest tasemest

  12. Magustoit filmihuvilistele lastele / Maris Balbat

    Index Scriptorium Estoniae

    Balbat, Maris, 1936-

    2002-01-01

    25. oktoobrist tuleb Coca-Cola Plaza ekraanile USA joonisfilm "Jääaeg" ("Ice Age"), mille dubleerimisse on režissöör Janno Põldma juhtimisel kaasatud head eesti näitlejad Anu Lamp, Lembit Ulfsak, Marko Matvere jt

  13. Kogemus kui ajalugu / David Carr ; inglise keelest tõlkinud Triinu Pakk ; toimetanud Tõnu Viik

    Index Scriptorium Estoniae

    Carr, David, 1940-

    2012-01-01

    Representatsioon, mälu, kogemus. Ajalisus. Intentsionaalsus ja loomuliku hoiaku maailm. Inimmaailm ja ajalooline maailm. Sotsiaalne aeg ning laiendatud minevik ja tulevik. Osalus ja liikmelisus. Ajaloolisus. Ajaloolisus ja ajalooline teadmine. Teaduse ajaloolisus. Ajaloo metafüüsika ja epistemoloogia.

  14. Töötajad hoolitsevad ise otstarbeka ajakasutuse eest / Merike Lees

    Index Scriptorium Estoniae

    Lees, Merike, 1976-

    2007-01-01

    Ilmunud ka: Delovõje Vedomosti 28. nov. lk. 38. Andes töötajatele vabaduse ise otsustada oma tööaja üle, paranevad nende töö efektiivsus ning ettevõtte majandustulemused. Lisa: Paindlik tööaeg toob kasu. Kommenteerib Aneta Jajkowska

  15. Kange prooviga Eesti kuld / Kristel Kossar

    Index Scriptorium Estoniae

    Kossar, Kristel

    2008-01-01

    Marina Kaljurannal täitub juulis kolm aastat suursaadikuna Venemaal, see aeg tõi talle mullu Eesti aasta inimese lugupidava tiitli. Marie Claire veetis temaga Moskvas ühe päeva, et tuua tükike suursaadiku elust miljonilinnas oma lugejateni

  16. Eesti filmil läks hästi Karlovy Vary festivalil / Marianne Kõrver

    Index Scriptorium Estoniae

    Kõrver, Marianne, 1980-

    2006-01-01

    Lühimängufilm "Tühirand", režissöör Veiko Õunpuu, osales Karlovy Vary rahvusvahelise filmifestivali "Forum of Independents" programmis. 41. Karlovy Vary filmifestivali avas Korea režissööri Kim Ki-duki "Aeg". Lühidalt ka auhinnatutest ja huvitavamatest filmidest

  17. Estonskii film prinimali teplo / Marianne Kõrver

    Index Scriptorium Estoniae

    Kõrver, Marianne, 1980-

    2006-01-01

    Lühimängufilm "Tühirand", režissöör Veiko Õunpuu, osales Karlovy Vary rahvusvahelise filmifestivali "Forum of Independents" programmis. 41. Karlovy Vary filmifestivali avas Korea režissööri Kim Ki-duki uusim film "Aeg". Lühidalt ka auhinnatutest ja huvitavamatest filmidest

  18. Muuga söeterminalil on probleemide lahendamiseks aega jaanipäevani / Ulvar Käärt

    Index Scriptorium Estoniae

    Käärt, Ulvar, 1982-

    2006-01-01

    AS Coal Terminal Operatori söeterminal Muugal, kust aeg-ajalt levib ümbruskonda söetolmu, töötab nii ilma välisõhu saasteloa kui ka vee erikasutusloata. Terminal kavandab meetmeid tolmuprobleemi lahendamiseks

  19. Tallinn Fashion Week täidab nädala kodumaise moega / Karilin Engelbrecht

    Index Scriptorium Estoniae

    Engelbrecht, Karilin

    2009-01-01

    Tallinn Fashion Week'i üritustest. Ülevaade eesti moekunstnike loomingu esitlustest. Näitus "Uus Eesti moejoonistus" Arhitektuuri- ja Disainigaleriis. Anu Hindi moefotonäitus "Aeg maha 3" Iida galeriis. Raamatu "Eesti moepiibel 2010" esitlus Rotermanni kvartali kohvikus Platz. Oksana Tanditi ja Filippo Caroti moefotonäitus "Butterflies" Tallinna botaanikaaias

  20. Эстонии пора думать о новом массовом строительстве жилья / Урмас Тооминг

    Index Scriptorium Estoniae

    Тооминг, Урмас, 1954-

    2011-01-01

    Eestis 1960–1990 ehitatud kortermajade eluiga hakkab paarikümne aasta pärast otsa saama. Aeg on algatada massilise elamuehituse käivitamise teemal mõttetalguid, et tulevikus vältida keerulist eluasemeprobleemi. Probleemi lahkavad MTÜ Eesti Arhitektuurikeskuse juhataja Ülar Mark ja Tallinna peaarhitekt Endrik Mänd

  1. Mõtteid isast ja ta ajast / Enn Soosaar

    Index Scriptorium Estoniae

    Soosaar, Enn, 1937-2010

    2006-01-01

    6. septembril möödub sada aastat praost Albert Soosaare (1906-1995) sünnist. Järgneb: 6. september, lk. 6; 13. september, lk. 6; 20. september, lk. 6; 27. september, lk. 6; 4. oktoober, lk 6; 11. oktoober, lk 6. Katkendid pärinevad pikemast esseest "Isa ja Aeg"

  2. Kunstnikud liikusid ajas ja ruumis / Anneli Kenk

    Index Scriptorium Estoniae

    Kenk, Anneli

    2001-01-01

    5. tegevuskunstifestivalist "Aeg Ruum Liikumine", kus esinesid Urmas Sisask (trumm ja joig), duo Pink Twins (Vesa ja Juha Vehviläinen Soomest), performance'ikunstnik Biro Jozsef, soome-sloveeni kunstnik Valter Kokot, paidelane Gert Hatsukov, Sorge, sakslased Helge Meyer ja Marco Teubner. Mari Sobolevi kommentaar

  3. Pathways through which health influences early retirement: A qualitative study

    NARCIS (Netherlands)

    A. de Wind (Astrid); G.A. Geuskens (Goedele); K.G. Reeuwijk (Kerstin); M.J. Westerman (Marjan); J.F. Ybema (Jan Fekke); A. Burdorf (Alex); P.M. Bongers (Paulien); A.J. van der Beek (Allard)

    2013-01-01

    textabstractBackground: Due to the aeging of the population, there is a societal need for workers to prolong their working lives. In the Netherlands, many employees still leave the workforce before the official retirement age of 65. Previous quantitative research showed that poor self-perceived heal

  4. Eestlased Peipsi taga mõisavalitsejaks / Heli Raamets

    Index Scriptorium Estoniae

    Raamets, Heli, 1975-

    2008-01-01

    AS Trigon Agri Heiki Volveri juhtimisel rajab Pihkva oblastisse Gdovi linna lähedal asuvasse Dobrutshi külla kaasaegset piimafarmi, projekti maksumuseks on ligi 10 miljonit eurot. Vt. samas: Venemaal kestab Vene aeg edasi; Trigon Agril kolmes riigis 35 põllumajandusettevõtet

  5. Lapsesamm Trullist Dostojevskini / Vaapo Vaher

    Index Scriptorium Estoniae

    Vaher, Vaapo, 1945-

    2011-01-01

    Tutvustus: Raitar, Maie ; Sööt, Andres. Konrad Mägi. Kunstnik. Looming. Aeg. Tartu : Ilmamaa, 2011 ; Fitzgerald, F. Scott. Maipüha. Tallinn : Eesti Raamat, 2011 ; Trull, Ilmar. Väike viisakas kärbes. Tallinn : Varrak, 2011

  6. Allkirjade alkeemiast / Maie Kiisel

    Index Scriptorium Estoniae

    Kiisel, Maie

    2011-01-01

    Autori arvates hakkab vanamoodsate kodanikualgatuste aeg läbi saama, tõusulainel on aga Internetis allkirjade jagamine. GMO-keelu tühistamise vastu koguti 1,2 mln. allkirja. Autor leiab, et liikmesriigid on Euroopa tasandi kodanikualgatust kartma hakanud

  7. Sobõtinoje vremja / Dmitri Mihhailov

    Index Scriptorium Estoniae

    Mihhailov, Dmitri

    2003-01-01

    Mõiste "aeg" füüsikalisest ja filosoofilisest tõlgendamisest. Nikolai Kozõrevi "põhjusliku mehhaanika" teooriast. Leibniz'i, Deleuze'i ja Whitehead'i aja käsitlustest. Vana-Kreeka ajajumalatest - Kronosest ja Aionist, nende vastandlikkusest ja ühtsusest

  8. Ilmusid Rahvusraamatukogu uuenenud toimetised / Mihkel Volt

    Index Scriptorium Estoniae

    Volt, Mihkel

    2009-01-01

    Tutvustus: Ajalookirjutaja aeg = Aetas historicorum / Eesti Rahvusraamatukogu ; koostanud Piret Lotman. (Eesti Rahvusraamatukogu toimetised, nr. 11). Tallinn, 2008 ; Teenuse kvaliteet – raamatukogutöö tulemuslikkuse näitaja = Service quality – library perfomance indicator / Eesti Rahvusraamatukogu ; koostanud Anne Veinberg. (Eesti Rahvusraamatukogu toimetised ; 12). Tallinn, 2009.

  9. Keskmise suurusega akutrellid / Rakennusmaailma põhjal Ingrid Maasik

    Index Scriptorium Estoniae

    2011-01-01

    Võrdluses on 14,4 V akutrell-kruvikeerajad: AEG BS14 C; Black&Decker HP146F4L; Bosch GSR 14,4 V-LI; Bosch PSR LI-2; Einhell RT-CD; Festool T 15+3; Hitachi DS 14BDL; Makita BDF442; Metabo LT; Milwaukee C14DD; Panasonic EY 7441LR; Spit SDI 145

  10. Andrus Saar: Neid inimesi, kes peavad õhtul tühja kõhuga magama minema, on ka parimatel aegadel olnud liiga palju / Andrus Saar ; intervjueerinud Katre Ratassepp

    Index Scriptorium Estoniae

    Saar, Andrus, 1946-

    2010-01-01

    Vaesuse ja sotsiaalse tõrjutuse vastu võitlemise Euroopa aasta Eesti hea tahte saadik leiab, et hirm kaotada töökoht on igati normaalne olukorras, kus inimesed ei ole informeeritud ettevõtte arengust ja perspektiividest ning et praegu oleks viimane aeg muuta toetuste süsteemi. Saar Polli poolt läbiviidud Eurobarometer Flash uuringust

  11. Elamu Pärnus Lõuna tn 2A / Jaak Huimerind

    Index Scriptorium Estoniae

    Huimerind, Jaak, 1957-

    2014-01-01

    Nõukogude aeg oli oma vaesus hea konservaator ja muinsuskaitsja. Kuidas käis eestiaegsete ehitiste käsi uue iseseisvusaja algul. Olev Siinmaa kaks kõige väärtuslikumat villat säilisid aastatuhande alguseni. Elamu Lõuna tn 2 restaureerimisest

  12. A new application of emulsions to measure the gravitational force on antihydrogen

    CERN Document Server

    Amsler, C; Ariga, T; Braccini, S; Canali, C; Ereditato, A; Kawada, J; Kimura, M; Kreslo, I; Pistillo, C; Scampoli, P; Storey, J W

    2013-01-01

    We propose to build and operate a detector based on the emulsion film technology for the measurement of the gravitational acceleration on antimatter, to be performed by the AEgIS experiment (AD6) at CERN. The goal of AEgIS is to test the weak equivalence principle with a precision of 1% on the gravitational acceleration g by measuring the position of the annihilation vertex antihydrogen atoms after their free fall in a horizontal vacuum pipe. With the emulsion technology developed at the University of Bern we propose to improve the performance of AEgIS by exploiting the superior position resolution of emulsion films over other particle detectors. The idea is to use a new type of emulsion films, especially developed for applications in vacuum, to yield a spatial resolution of the order of one micron in the measurement of the sag of the antihydrogen atoms in the gravitational field. This is an order of magnitude better than what was planned in the original AEgIS proposal.

  13. Mart Laar tuleb peatada / Villu Reiljan

    Index Scriptorium Estoniae

    Reiljan, Villu, 1953-

    2001-01-01

    Ilmunud ka: Vooremaa, 8. dets. 2001, lk. 2; Nädaline, 8. dets. 2001, lk. 4; Võrumaa Teataja, 11. dets. 2001, lk. 2; Järva Teataja, 13. dets. 2001, lk. 2. Kuigi ca 70% Eesti rahvast on elektrijaamade erastamise vastu, on Mart Laari valitsus ignoreerinud rahva tahet, talle on kogu aeg sekundeerinud Mihkel Pärnoja. Autor: ERL. Parlamendisaadik

  14. Research into the Bronze and Early Iron Ages / Aivar Kriiska

    Index Scriptorium Estoniae

    Lang, Valter, 1958-

    2006-01-01

    19. sajandil olid mõisted pronksiaeg ja eelrooma rauaaeg praktiliselt tundmatud. Kuni 1950ndateni domineeris rooma rauaaja uurimine. Nüüd on selgunud, et seni kultuurilise depressiooni perioodiks peetud aeg (tuntud kivikirstkalmete perioodina), oli tegelikult üks dünaamilisemaid perioode Eesti esiajaloos. Eesti ala ebaühtlasest asustusest sel perioodil

  15. Kroonika - chronicle (2006)

    Index Scriptorium Estoniae

    2007-01-01

    Helilooja Eduard Tubina helitööde ettekannete, raamatute, artiklite, helisalvestiste nimekiri. Dokumente ja väljavõtteid artiklitest, mis sisaldavad Vardo Rumesseni kirju peaministrile, kultuuriministrile ja BNS teadet dirigent Neeme Järvi kriitilisest suhtumisest kultuuriministeeriumisse seoses festivaliga "Tubin ja tema aeg"

  16. Microwave Antennas for Avionics. Lecture Series of the Avionics Panel and the Consultant and Exchange Programme Held in Rome, Italy on 7-8 May 1987; Guenzburg, Germany on 11-12 May 1987 and Ankara, Turkey on 14-15 May 1987.

    Science.gov (United States)

    1987-04-01

    by , , Klaus Solbach ’ ■"’."’ AEG, Radio & Radar Systems Division ■ ■ Radar Subdivision A14 ElOl...Silver, Editor, "Microwave Antenna Theory and Design", Rad. Lab. Series, MC Graw -Hill Book Company, 1949 /5/ R. C. Hansen, Editor, "Microwave

  17. Kuula ka neid

    Index Scriptorium Estoniae

    2012-01-01

    Lühidalt heliplaatidest: Wagner, Strauss, Seeger. Eesti Rahvusmeeskoor, eesti Kaitseväe Orkester; Kalinka. Lembit Tolga; Cesena. Graindelavoix, Björn Schmelzer; Igavene suvi. Allan Vainola & Unenäopüüdjad; Odysseia. European Jazz Motion. Meie aeg on käes. August Hunt; Maksmata võlad. legshaker; Magnificat. Kammerkoor Studio Vocale

  18. Kolmanda raamatu kiituseks / Peeter Olesk

    Index Scriptorium Estoniae

    Olesk, Peeter, 1953-

    2009-01-01

    Tutvustus: Isaacson, Walter. Einstein : tema elu ja universum / tõlkinud Matti Piirimaa. Tallinn : Eesti Raamat, 2009; Fortey, Jacqueline. Kuulsad teadlased (Silmaring) / tõlkinud Ülle Haav ja Helen Haav. Tallinn : Koolibri, 2009; Vaim ja aeg (Lehed ja tähed : looduse ja teaduse aastaraamat, 5) / koostanud Indrek Rohtmets ja Toomas Kukk. Tallinn : Loodusajakiri, 2009

  19. Alar Pääro La Galerie Passage'is / Viivi Põlma

    Index Scriptorium Estoniae

    Põlma, Viivi

    2000-01-01

    Iseõppijast maalikunstniku Alar Pääro esimene personaalnäitus "On aeg" 20. I-20. II La Galerie Passage'is. 1993. aastast on A. Pääro töötanud vabakutselise kunstnikuna, mida on talle võimaldanud metseen Kalev Klais

  20. Kas kolm ikka on koolipoisi number? / Mare Leino

    Index Scriptorium Estoniae

    Leino, Mare, 1961-

    2009-01-01

    Artiklikogumiku ""Probleemsed" poisid või "vale" temperament?" (Tallinn, 2009) tutvustus. Kogumik osutab, et tänapäeva kool sobib tüdrukutele paremini kui poistele. On aeg hakata senisest põhjalikumalt uurima, miks see nii on

  1. Briti peaminister Blair : põhiseadusleping vajab aega järelemõtlemiseks / Kaivo Kopli

    Index Scriptorium Estoniae

    Kopli, Kaivo

    2005-01-01

    Peagi EL-i eesistujamaaks saava Suurbritannia peaminister Tony Blair soovitab pärast EL-i põhiseaduslepingu tagasilükkamist Prantsusmaal ja Hollandis aeg maha võtta, järele mõelda ning arutada asja Euroopa ülemkogus

  2. Individual concrete panels

    DEFF Research Database (Denmark)

    2008-01-01

    DVD én formidler en workshop omhandlende udvikling, optimering og produktion af individuelle betonelementer. Workshoppen fandt sted 8. til 13. oktober 2007 i en af Peter Behren´s AEG turbinehaller i Berlin, hvor 10. arkitektstuderende fra Århus satte 10. inginiørstuderende fra tekniske universite...

  3. Addressing information needs to reduce the audit expectation gap : Evidence from Dutch bankers, audited companies and auditors

    NARCIS (Netherlands)

    Litjens, Robin

    2015-01-01

    This study examines what the impact is of frequently proposed information needs on reducing the audit expectations gap (AEG), including information about the audited company, information about the audit process and changes to the auditors' report. We base our findings on a survey of 302 participants

  4. Budjet li polza dlja ekonomiki stranõ?

    Index Scriptorium Estoniae

    2005-01-01

    Valitsuse programmist töötajate koondamisel, tööandjate pakutud variant 14+14 (töötaja koondamise puhul kahenädalane etteütlemise aeg ja kaks nädalat kompensatsiooni). Arvamust avaldavad: Eiki Nestor, Mart Opmann, Fjodor Berman, Harri Taliga ja Vitali Burlakov

  5. Eesti ettevõtete maksekäitumine on kahe aastaga tunduvalt paranenud / Merike Lees

    Index Scriptorium Estoniae

    Lees, Merike, 1976-

    2005-01-01

    Ilmunud ka: Delovõje Vedomosti 20. juuli lk. 14. Intrum Justitia uuringust selgus, et Eesti ettevõtete keskmine makseviivituse aeg on lühenenud aastaga kahe päeva võrra. Diagramm. Vt. samas: Toomas Marga. Makseriskide juhtimine on osa igapäevasest klienditeenindusest. Lisa: Krediidipoliitika on endiselt koordineerimata valdkond. Diagramm

  6. Majandustarkvara turg : Eesti väikefirma vajab võimsat tarkvara / Indrek Saul

    Index Scriptorium Estoniae

    Saul, Indrek, 1961-

    1999-01-01

    Eesti majandustarkvara turu analüüsimisel on praegu keskne küsimus turu liigendamine toote ja kliendi tunnuste järgi. Tabelid: ettevõtete liigitus käibe ja töötajate arvu järgi, majandustarkvara liigitus võimsuse järgi, majandustarkvara pakkujad Eestis, majandustarkvara kasutajatugi, majandustarkvara firma turul oleku aeg

  7. Halb nullvariant / Rein Taagepera

    Index Scriptorium Estoniae

    Taagepera, Rein, 1933-

    2002-01-01

    Ilmunud ka: Infopress 9. august nr. 32 lk. 34. On aeg uuesti läbi mõelda, kuidas süvendada eesti meelt ja eesti keelt 220 000 mittekodaniku hulgas. Kodakondsuseksami asemel võiks kaaluda 150-tunnise harjutuse läbimist, pakub autor. Autor: Res Publica

  8. Hirmu teretulnud naasmine maailma rahaturgudele / Martin Wolf ; tõlk. Erik Aru

    Index Scriptorium Estoniae

    Wolf, Martin

    2007-01-01

    Ajalehe The Financial Times majanduskommentaator finantskriisist maailmamajanduses. Tõenäoliselt saabub kahjumite kokkuarvamise, karmistuvate krediiditingimuste ja laenukoormuste vähendamise aeg, mis toob kaasa tugeva surve intressimäärade järsuks langetamiseks, et kriisiohtlik süsteem hädast päästa. Sellele survele tuleks vastu hakata nii kaua kui võimalik

  9. Maramaa elust poksi ja graffitini / Andres Lepik, Ott Aardam ; interv. Gert Kiiler

    Index Scriptorium Estoniae

    Lepik, Andres

    2008-01-01

    Ugala teater alustas 89. hooaega. Esimese poole plaanitud esietendused : Toomas Suumani "Linnapea" Heiki Raudla raamatu "August Maramaa aeg" järgi, lavastaja Andres Lepik. Ott Aardami noortetükist "Poks", lavastaja autor. Gerald Sibleyras' "Grafiti", lavastaja Taago Tubin. Silvia Soro jõulunäidend "Inetu pardipoja" ainetel, lavastaja Oleg Titov

  10. Seletamatu ja koomiline sajandilõpp / Sulev Teinemaa

    Index Scriptorium Estoniae

    Teinemaa, Sulev, 1947-

    1998-01-01

    Mängufilmid II Pimedate Ööde Filmifestivalil : "Must kass, valge kass" ("Crna mack, beli macor"), režissöör Emir Kusturica : Jugoslaavia - Prantsusmaa 1998; "Tantsija aeg" ("Vremja tantsora"), režissöör Vadim Abdrashitov : Venemaa 1997; "Helge homne" ("The Sweet Hereafter"), režissöör Atom Egoyan : Kanada 1997

  11. Kirjastusuudiseid

    Index Scriptorium Estoniae

    2006-01-01

    eesti Kunstimuuseumi kirjastatud raamatud "Vene valitsejad. Vene valitsejate portreed Eesti muuseumide kogudest" (koostajad Mai Levin, Aleksandra Murre; kujundaja Peeter Laurits), "Eros ja Surm. Felicien Ropsi looming" (toimetaja Tiina Abel, kujundaja Mari Kaljuste) ja märkmik-kalender "Inimene ja aeg. Päevaraamat" (kujundaja Jaak Peep)

  12. Moss Pathogenesis-Related-10 Protein Enhances Resistance to Pythium irregulare in Physcomitrella patens and Arabidopsis thaliana.

    Science.gov (United States)

    Castro, Alexandra; Vidal, Sabina; Ponce de León, Inés

    2016-01-01

    Plants respond to pathogen infection by activating signaling pathways leading to the accumulation of proteins with diverse roles in defense. Here, we addressed the functional role of PpPR-10, a pathogenesis-related (PR)-10 gene, of the moss Physcomitrella patens, in response to biotic stress. PpPR-10 belongs to a multigene family and encodes a protein twice the usual size of PR-10 proteins due to the presence of two Bet v1 domains. Moss PR-10 genes are differentially regulated during development and inoculation with the fungal pathogen Botrytis cinerea. Specifically, PpPR-10 transcript levels increase significantly by treatments with elicitors of Pectobacterium carotovorum subsp. carotovorum, spores of B. cinerea, and the defense hormone salicylic acid. To characterize the role of PpPR-10 in plant defense against pathogens, we conducted overexpression analysis in P. patens and in Arabidopsis thaliana. We demonstrate that constitutive expression of PpPR-10 in moss tissues increased resistance against the oomycete Pythium irregulare. PpPR-10 overexpressing moss plants developed less symptoms and decreased mycelium growth than wild type plants. In addition, PpPR-10 overexpressing plants constitutively produced cell wall depositions in protonemal tissue. Ectopic expression of PpPR-10 in Arabidopsis resulted in increased resistance against P. irregulare as well, evidenced by smaller lesions and less cellular damage compared to wild type plants. These results indicate that PpPR-10 is functionally active in the defense against the pathogen P. irregulare, in both P. patens and Arabidopsis, two evolutionary distant plants. Thus, P. patens can serve as an interesting source of genes to improve resistance against pathogen infection in flowering plants.

  13. Moss Pathogenesis-Related-10 protein enhances resistance to Pythium irregulare in Physcomitrella patens and Arabidopsis thaliana

    Directory of Open Access Journals (Sweden)

    Alexandra eCastro

    2016-04-01

    Full Text Available Plants respond to pathogen infection by activating signaling pathways leading to the accumulation of proteins with diverse roles in defense. Here, we addressed the functional role of PpPR-10, a pathogenesis-related (PR-10 gene, of the moss Physcomitrella patens, in response to biotic stress. PpPR-10 belongs to a multigene family and encodes a protein twice the usual size of PR-10 proteins due to the presence of two Bet v1 domains. Moss PR-10 genes are differentially regulated during development and inoculation with the fungal pathogen Botrytis cinerea. Specifically, PpPR-10 transcript levels increase significantly by treatments with elicitors of Pectobacterium carotovorum subsp. carotovorum, spores of B. cinerea, and the defense hormone salicylic acid. To characterize the role of PpPR-10 in plant defense against pathogens, we conducted overexpression analysis in P. patens and in Arabidopsis thaliana. We demonstrate that constitutive expression of PpPR-10 in moss tissues increased resistance against the oomycete Pythium irregulare. PpPR-10 overexpressing moss plants developed less symptoms and decreased mycelium growth than wild type plants. In addition, PpPR-10 overexpressing plants constitutively produced cell wall depositions in protonemal tissue. Ectopic expression of PpPR-10 in Arabidopsis resulted in increased resistance against P. irregulare as well, evidenced by smaller lesions and less cellular damage compared to wild type plants. These results indicate that PpPR-10 is functionally active in the defense against the pathogen P. irregulare, in both P. patens and Arabidopsis, two evolutionary distant plants. Thus, P. patens can serve as an interesting source of genes to improve resistance against pathogen infection in flowering plants.

  14. Astrocyte Elevated Gene-1 as a Novel Clinicopathological and Prognostic Biomarker for Gastrointestinal Cancers: A Meta-Analysis with 2999 Patients.

    Directory of Open Access Journals (Sweden)

    Yihuan Luo

    Full Text Available There have been numerous articles as to whether the staining index (SI of astrocyte elevated gene-1 (AEG-1 adversely affects clinical progression and prognosis of gastrointestinal cancers. Nevertheless, controversy still exists in terms of correlations between AEG-1 SI and clinicopathological parameters including survival data. Consequently, we conducted a comprehensive meta-analysis to confirm the role of AEG-1 in clinical outcomes of gastrointestinal carcinoma patients.We performed a comprehensive search in PubMed, ISI Web of Science, Cochrane Central Register of Controlled Trials, EMBASE, Science Direct, Wiley Online Library, China National Knowledge Infrastructure (CNKI, WanFang and Chinese VIP databases. STATA 12.0 (STATA Corp., College, TX was used to analyze the data extracted from suitable studies and Newcastle-Ottawa Scale was applied to assess the quality of included articles.The current meta-analysis included 2999 patients and our results suggested that strong associations emerged between AEG-1 SI and histological differentiation (OR = 2.129, 95%CI: 1.377-3.290, P = 0.001, tumor (T classification (OR = 2.272, 95%CI: 1.147-4.502, P = 0.019, lymph node (N classification (OR = 2.696, 95%CI: 2.178-3.337, P<0.001 and metastasis (M classification (OR = 3.731, 95%CI: 2.167-6.426, P<0.001. Furthermore, high AEG-1 SI was significantly associated with poor overall survival (OS (HR = 2.369, 95%CI: 2.005-2.800, P<0.001 and deteriorated disease-free survival (DFS (HR = 1.538, 95%CI: 1.171-2.020, P = 0.002. For disease-specific survival (DSS and relapse-free survival (RFS, no statistically significant results were observed (HR = 1.573, 95%CI: 0.761-3.250, P = 0.222; HR = 1.432, 95%CI: 0.108-19.085, P = 0.786. Subgroup analysis demonstrated that high AEG-1 SI was significantly related to poor prognosis in esophageal squamous cell carcinoma (ESCC (HR = 1.715, 95%CI: 1.211-2.410, P = 0.002, gastric carcinoma (GC (HR = 2.255, 95%CI: 1.547-3.288, P<0

  15. 75 FR 39680 - Houston Pipe Line Company LP, Worsham-Steed Gas Storage, L.P., Energy Transfer Fuel, LP, Mid...

    Science.gov (United States)

    2010-07-12

    ... Storage, L.P., Energy Transfer Fuel, LP, Mid Continent Market Center, L.L.C., Oasis Pipeline, LP (Not... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR10-44-000; Docket No. PR10-46-000; Docket No....

  16. Seven different genes encode a diverse mixture of isoforms of Bet v 1, the major birch pollen allergen

    NARCIS (Netherlands)

    Schenk, M.F.; Gilissen, L.J.W.J.; Esselink, G.D.; Smulders, M.J.M.

    2006-01-01

    Background: Pollen of the European white birch (Betula pendula, syn. B. verrucosa) is an important cause of hay fever. The main allergen is Bet v 1, member of the pathogenesis-related class 10 (PR-10) multigene family. To establish the number of PR-10/Bet v 1 genes and the isoform diversity within a

  17. Extended wavelet transformation to digital holographic reconstruction: application to the elliptical, astigmatic Gaussian beams.

    Science.gov (United States)

    Remacha, Clément; Coëtmellec, Sébastien; Brunel, Marc; Lebrun, Denis

    2013-02-01

    Wavelet analysis provides an efficient tool in numerous signal processing problems and has been implemented in optical processing techniques, such as in-line holography. This paper proposes an improvement of this tool for the case of an elliptical, astigmatic Gaussian (AEG) beam. We show that this mathematical operator allows reconstructing an image of a spherical particle without compression of the reconstructed image, which increases the accuracy of the 3D location of particles and of their size measurement. To validate the performance of this operator we have studied the diffraction pattern produced by a particle illuminated by an AEG beam. This study used mutual intensity propagation, and the particle is defined as a chirped Gaussian sum. The proposed technique was applied and the experimental results are presented.

  18. Final report on the development of a disturbanceless NDE compact cooling device; Abschlussbericht zur Entwicklung einer stoerarmen maschinellen NDE-Kompaktkuehlung

    Energy Technology Data Exchange (ETDEWEB)

    Kaiser, G.

    2002-08-13

    The project comprised the following aspects: 1. Development of a disturbance-free, mechanized compact cooling system for a NDE measuring system on the basis of a commercial SL200-10 split stirling cooling system of AEG Infrarotmodule GmbH, Heilbronn; 2. Support of the development work at the HTSL/Hall magnetometer of Friedrich-Schiller University, Jena; 3. Measurements of HTSL/Hall magnetometer samples and thermal characterisation. [German] Im Rahmen dieses Vorhabens wurden die folgenden Aufgabenstellungen behandelt: 1. Entwicklung einer stoerarmen, maschinellen Kompaktkuehlung fuer ein NDE-Messsystem auf der Basis eines kommerziellen Split-Stirlingkuehlers SL200-10 der Firma AEG Infrarotmodule GmbH, Heilbronn, 2. Unterstuetzung der Entwicklungsarbeiten am HTSL/Hall-Magnetometer, die bei der Friedrich-Schiller-Universitaet in Jena durchgefuehrt wurden, 3. Messungen an HTSL/Hall-Magnetometer-Proben zu deren thermischer Charakterisierung. (orig.)

  19. Investigation of silicon sensors for their use as antiproton annihilation detectors

    Energy Technology Data Exchange (ETDEWEB)

    Pacifico, N., E-mail: nicola.pacifico@cern.ch [University of Bergen, Institute of Physics and Technology, Allégaten 55, 5007 Bergen (Norway); Aghion, S. [Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano (Italy); Istituto Nazionale di Fisica Nucleare, Sez. di Milano, Via Celoria 16, 20133 Milano (Italy); Ahlén, O. [European Organisation for Nuclear Research, Physics Department, 1211 Geneva 23 (Switzerland); Belov, A.S. [Institute for Nuclear Research of the Russian Academy of Sciences, Moscow 117312 (Russian Federation); Bonomi, G. [University of Brescia, Department of Mechanical and Industrial Engineering, Via Branze 38, 25133 Brescia (Italy); Istituto Nazionale di Fisica Nucleare, Sez. di Pavia, Via Agostino Bassi 6, 27100 Pavia (Italy); Bräunig, P. [Kirchhoff Institute for Physics, Im Neuenheimer Feld 227, 69120 Heidelberg (Germany); Bremer, J. [European Organisation for Nuclear Research, Physics Department, 1211 Geneva 23 (Switzerland); Brusa, R.S. [Department of Physics, University of Trento, via Sommarive 14, 38123 Povo, Trento (Italy); INFN-TIFPA, via Sommarive 14, 38123 Povo, Trento (Italy); Burghart, G. [European Organisation for Nuclear Research, Physics Department, 1211 Geneva 23 (Switzerland); Cabaret, L. [Laboratoire Aimé Cotton, CNRS, Université Paris Sud, ENS Cachan, Bâtiment 505, Campus d' Orsay, 91405 Orsay Cedex (France); Caccia, M. [University of Insubria, Dipartimento di Scienza ed Alta Tecnologia, via Valleggio 11, Como (Italy); Canali, C. [University of Zurich, Physics Institute, Winterthurerstrasse 190, 8057 Zurich (Switzerland); Caravita, R. [Istituto Nazionale di Fisica Nucleare, Sez. di Genova, Via Dodecaneso 33, 16146 Genova (Italy); University of Genoa, Department of Physics, Via Dodecaneso 33, 16146 Genova (Italy); Castelli, F. [University of Milano, Department of Physics, Via Celoria 16, 20133 Milano (Italy); and others

    2014-11-21

    We present here a new application of silicon sensors aimed at the direct detection of antinucleons annihilations taking place inside the sensor's volume. Such detectors are interesting particularly for the measurement of antimatter properties and will be used as part of the gravity measurement module in the AEg{sup ¯}IS experiment at the CERN Antiproton Decelerator. One of the goals of the AEg{sup ¯}IS experiment is to measure the gravitational acceleration of antihydrogen with 1% precision. Three different silicon sensor geometries have been tested with an antiproton beam to investigate their properties as annihilation detection devices: strip planar, 3D pixels and monolithic pixel planar. In all cases we were successfully detecting annihilations taking place in the sensor and we were able to make a first characterization of the clusters and tracks.

  20. Parkimistrahvide aegumise küsimuses valitseb segadus / Sandra Maasalu

    Index Scriptorium Estoniae

    Maasalu, Sandra

    2007-01-01

    Justiitsministeerium peab vajalikuks täpsustada seadusi nii, et parkimistrahvi sissenõudmise aeg oleks täpselt määratletud. Kommenteerib justiitsminister Rein Lang. Vt ka: Koorits, Vahur. Röövimine aegub parkimistrahvist varem // Postimees 8. aug. 2007, lk. 3 ; Suik, Andres. Parkimistrahv aegub kiirelt : inimeste suhtes ei saa täita aegunud otsuseid // Postimees 14. aug. 2007, lk. 15

  1. Kui tulusid ei ole võimalik suurendada, tuleb piirata kulutamist / Eugen Veges

    Index Scriptorium Estoniae

    Veges, Eugen, 1955-

    2008-01-01

    Ilmunud ka: Lääne Elu 17. mai lk. 2, Põhjarannik, Severnoje Poberezhje 22. mai lk. 4, Kuulutaja 30. mai lk. 4, Meie Maa 31. mai lk. 2, Vooremaa 3. juuni lk. 2, Järva Teataja 5. juuni lk. 2. Eesti ettevõtjail on ees raske aeg, ettevõtete tulusus langeb. Autori sõnul tuleb riigi tulubaasi suurendamiseks kehtestada uusi makse või suurendada seniseid maksulaekumisi. Haldusreform on möödapääsmatu

  2. Facile synthesis of novel 3D nanoflower-like Cu(x)O/multilayer graphene composites for room temperature NO(x) gas sensor application.

    Science.gov (United States)

    Yang, Ying; Tian, Chungui; Wang, Jingchao; Sun, Li; Shi, Keying; Zhou, Wei; Fu, Honggang

    2014-07-01

    3D nanoflower-like CuxO/multilayer graphene composites (CuMGCs) have been successfully synthesized as a new type of room temperature NOx gas sensor. Firstly, the expanded graphite (EG) was activated by KOH and many moderate functional groups were generated; secondly, Cu(CH3COO)2 and CTAB underwent full infusion into the interlayers of activated EG (aEG) by means of a vacuum-assisted technique and then reacted with the functional groups of aEG accompanied by the exfoliation of aEG via reflux. Eventually, the 3D nanoflower consisting of 5-9 nm CuxO nanoparticles homogeneously grow in situ on aEG. The KOH activation of EG plays a key role in the uniform formation of CuMGCs. When being used as gas sensors for detection of NOx, the CuMGCs achieved a higher response at room temperature than that of the corresponding CuxO. In detail, the CuMGCs show a higher NOx gas sensing performance with low detection limit of 97 ppb, high gas response of 95.1% and short response time of 9.6 s to 97.0 ppm NOx at room temperature. Meanwhile, the CuMGC sensor presents a favorable linearity, good selectivity and stability. The enhancement of the sensing response is mainly attributed to the improved conductivity of the CuMGCs. A series of Mott-Schottky and EIS measurements demonstrated that the CuMGCs have much higher donor densities than CuxO and can easily capture and migrate electrons from the conduction band, resulting in the enhancement of electrical conductivity.

  3. Rahvuse mõju noorte tööturule sisenemise edukusele = The influence of ethnicity on youth labour market entry : III koht magistritööde kategoorias / Kristina Lindemann

    Index Scriptorium Estoniae

    Lindemann, Kristina, 1984-

    2009-01-01

    Magistritöö eesmärgiks oli uurida, kuidas mõjutasid rahvus ja eesti keele oskus noorte tööturule sisenemise edukust ajaperioodil 1991-2006 ning kuidas mõjutasid inimese rahvus, keeleoskus, haridustase, tööturule sisenemise aeg ja elukoht tõenäosust lülituda spetsialistide ja ametnike või sinikraede positsioonile

  4. Rock'n'roll'i hotellipidaja / Ants Johanson

    Index Scriptorium Estoniae

    Johanson, Ants, 1962-

    2008-01-01

    Ansamblist Rock Hotel (ansambli 30. sünnipäeva tähistamise juubelikontsertdid toimuvad 14. okt. Pärnu Endla teatris, 15. okt. Rakvere Teatris, 16. okt. Viljandi Pärimusmuusika Aidas, 17. okt. Paide kultuurikeskuses, 18. okt. Võru kultuurimajas Kannel, 19. okt. Vanemuise väikeses majas ja 20. okt. Vene Teatris, 9. okt. toimub Tallinnas Viru Keskuse kaupluses Rahva Raamat mälestusteraamatu "Aeg meid muutnud on? - Rock-Hotel 30" esitlus)

  5. The Zebra Battery: a South African contender for electric vehicle application

    Directory of Open Access Journals (Sweden)

    J. Coertzer

    1996-07-01

    Full Text Available The Zebra battery is one of the most promising power sources for electric vehicles which might be on sale before the year 2000. It is a South African development which started at the CSIR and is at present jointly managed by the Anglo American Corpora­tion of S.A. and the German company A.E.G. The chemical reaction converts common salt and nickel to nickel chloride and sodium during the charging phase.

  6. Rahandusministeerium : Eestit ootab ees galopeeriv hinnatõus / Kai Kalamees

    Index Scriptorium Estoniae

    Kalamees, Kai

    2007-01-01

    Ilmunud ka: Postimees : na russkom jazõke, 23. aug. 2007, lk. 2. Rahandusministeeriumi prognoosi järgi ootab Eestit 8,1%-line majanduskasv, 2008. aastal 7,4%-line hinnatõus. Rahandusminister Ivari Padari ja üle-eelmise rahandusministri parlamendiliikme Taavi Veskimäe arvamusi palgakasvu, inflatsiooni ja lisaeelarve kohta. Vt. samas: Käes on poliitiliste valikute aeg

  7. Moesõber, sel nädalal riisu koor Eesti rõivakunstilt! / Tanel Veenre

    Index Scriptorium Estoniae

    Veenre, Tanel, 1977-

    2009-01-01

    3. Tallinna moenädala üritustest. Tallinn Fashion Week'i korraldab Eesti Moedisaini Liit. Näitus "Uus Eesti moejoonistus" Arhitektuuri- ja Disainigaleriis. Filippo Caroti ja Oksana Tanditi moefotonäitus Tallinnas Galeriis M. Meesteehete väljapanek ja Anu Hindi moefotonäitus "Aeg maha 3" Iida galeriis. "Eesti moepiibel 2010" esitlus. Rahvusvaheline seminar Veerenni 24. Ülevaade eesti moekunstnike loomingu esitlustest

  8. Uudised : "Springjazz" Moskvas. 26. märtsil on Euroraadios Bachi päev. Aarne Saluveer juhib Kooriühingut / Hugo Alter

    Index Scriptorium Estoniae

    Alter, Hugo-Eduard, 1929-2003

    2000-01-01

    20. märtsil Moskvas Eesti saatkonnas toimunud jazzkontserdist "Springjazz". 26. märtsil on Euroopa Ringhäälingute Liitu (EBU) kuuluvatel raadiojaamadel eetris muusikaprogramm "Bach ja tema aeg", millega tähistatakse käesolevat Bachi aastat. 18. märtsil toimunud Eesti Kooriühingu aruande-valimiskoosolekust, kus esitati aruandeid ühingu tegevusest ja valiti juhatuse uueks esimeheks A. Saluveer

  9. Julgus palgata puuetega inimesi annaks töökäsi / Agne Narusk

    Index Scriptorium Estoniae

    Narusk, Agne, 1971-

    2005-01-01

    AS-is Standard töötab neli puudega töömeest. Tööandjate keskliidu infojuhi Kadri Seederi hinnangul on mööda saamas aeg, mil tööandjad pelgasid puudega töötajatega kaasnevaid lisakohustusi. Lisa: Tasuta abivahendid. 2002. aasta uuringu kohaselt töötas 27% puudega inimestest. Tugiisiku abi

  10. Locally oriented information, calculation and documentation of networks with process connection

    Energy Technology Data Exchange (ETDEWEB)

    Brauner, G.

    1988-10-24

    Modular LORIS systems (Locally Oriented Information System) execute supply network information, documentation, calculation and simulation tasks and include software and hardware as well as system consulting, training and service functions. Services can be ranging from the scanning and digitalization of planned systems to network consulting and data base design services. LORIS can be connected to AEG network control systems (EVU 800) substation control and protection system (ILS system) to fulfill background functions for production data acquisition and fault location.

  11. Department of Defense Review of the Foreign Comparative Testing Program FY2005-FY2006

    Science.gov (United States)

    2007-04-01

    sided multi-spectral camouflage nets from Fibrotex, Ltd. of Israel, GMA Cover Corporation of Canada, and Saab Barracuda LLC of Sweden. A...Cooler Germany AEG Infrarot Modules 1997 Ultra-Lightweight Camouflage Net System Sweden Diab- Barracuda 1997 2kW Generator Sets for Mobile Electric...Manassas, Virginia for this ongoing Navy FCT project. Ultra Lightweight Camouflage Net System. Diab- Barracuda of Sweden, now part of Saab, is supplying

  12. Kümme aastat R-klubi / Maria-Maren Sepper

    Index Scriptorium Estoniae

    Sepper, Maria-Maren

    2014-01-01

    R-klubi (aeg-ajalt Tallinnas kogunev klubi, mis pakub tagasisidet eesti keele alases uurimistöös, ennekõike väitekirjauurimuste tegemisel ja artiklite publitseerimisel) 10. aastapäeva puhul peetud seminarist Tallinna Ülikoolis 21.3.2014. R-klubi sai alguse Helle Metslangi juhendatavate TLÜ kraadiõppurite tööde ühisaruteludest

  13. Omad võõraste hulgas / Viktor Matizen ; tõlk. Tamara Korts

    Index Scriptorium Estoniae

    Matizen, Viktor

    2004-01-01

    Moskvas lõppes XXVI rahvusvaheline filmifestival. Peapreemia sai venelase Dmitri Meshijevi "Omad" ("Svoi"), FIPRESCI auhinna Marina Razbezhkina "Lõikuse aeg" ("Vremja zhatvõ"), publiku auhinna Vladimir Mashkovi "Isa" ("Papa!"), vene kriitikute auhinna brasiillase Heitor Dhalia "Nina", konkursi "Perspektiiv" auhinna jaapanlane Hideta Takahata ("Hotell Veenus") ja žürii eriauhinna Hõbedase Püha Jüri eestlaste Jaak Kilmi ja Rene Reinumägi "Sigade revolutsioon"

  14. EST Table: FY003280 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available FY003280 bmov10d18 11/11/04 42 %/142 aa ref|XP_001648294.1| Juvenile hormone-induci...ble protein, putative [Aedes aegypti] gb|EAT44634.1| Juvenile hormone-inducible protein, putative [Aedes aeg...A 11/11/04 34 %/139 aa gi|91080979|ref|XP_974925.1| PREDICTED: similar to Juvenile hormone-inducible protein, putative [Tribolium castaneum] FS808716 bmov ...

  15. Poeetilise utoopia meister Aino Bach

    Index Scriptorium Estoniae

    2003-01-01

    28. III-11. V Adamson-Ericu muuseumis graafik Aino Bachi loomingu ülevaatenäitus. Võrdluseks on eksponeeritud Eduard Wiiralti ja Kaarel Liimandi tööd. Näha võib Mark Soosaare filmi A. Bachist "Liblikapüüdja" (1978). Kuraator Anne Lõugas, kujundaja Virge Jõekalda. Kai Tuviku juhendamisel muuseumitunnid "Kuidas joonistada inimest?". 1. IV seminaril "Naiskunstnik ja tema aeg. Aino Bach" esinejad, ettekanded

  16. Kunstikonkurss "Oma silmaga" 2009. aastal / Lili Saksing

    Index Scriptorium Estoniae

    Saksing, Lili

    2009-01-01

    Kehtna Kunstide Kooli korraldatav Raplamaa laste ja noorte kunstikonkurss "Oma silmaga" toimub 2009. a. teemal "Mõttemaja". Ülesandeks on luua tasapinnaline töö, kus kujutatakse Raplamaal asuvat mõttemaja, mille töö autor on ise kavandanud ja sobitanud valitud ümbrusse. Rändnäitus 2008. a. konkursi töödest teemal "Aeg ja mina" on jõudnud Kohila Koolituskeskusesse Tohisoo mõisas

  17. Vabariigi presidendi iseseisvuspäeva kõne / Toomas Hendrik Ilves

    Index Scriptorium Estoniae

    Ilves, Toomas Hendrik, 1953-

    2009-01-01

    Vabariigi Presidendi kõne Eesti Vabariigi 91. aastapäeva pidulikul kontserdil Jõhvi kontserdimajas 24. veebruaril 2009. Arvamust avaldavad Euroopa Parlamendi liige Siiri Oviir, suurärimees Tiit Vähi, Eesti katoliku kiriku piiskop Philippe Jourdan, Tartu Ülikooli rektor Alar Karis, Eesti Kunstiakadeemia rektor Signe Kivi ja helilooja Olav Ehala. Vt. ka lk. 1: Ilves hoiatas populismi eest; juhtkiri lk. 2: Aeg kaitsta vabadust

  18. Collisional Dephasing and the Reduction of Laser Phase-Noise to Amplitude-Noise Conversion in a Resonant Atomic Vapor

    Science.gov (United States)

    2007-11-02

    Further, since the samev alue of P, is obtained for both curves, this statement ap- Here, keg and iAeg are the transition wavelength and dipole pears to be...pressure to have no effect on the signal-to- 1 noise ratio and to simply increase Av, thereby degrading A 10-4 spectroscopic sensitivity. However, as shown...and evaluation. Space Materials Laboratory: Evaluation and characterizations of new materials and processing techniques: metals, alloys , ceramics

  19. Functional and immunohistochemical characterization of CCEae3a, a carboxylesterase associated with temephos resistance in the major arbovirus vectors Aedes aegypti and Ae. albopictus.

    Science.gov (United States)

    Grigoraki, Linda; Balabanidou, Vassileia; Meristoudis, Christos; Miridakis, Antonis; Ranson, Hilary; Swevers, Luc; Vontas, John

    2016-07-01

    Temephos is a major organophosphate (OP) larvicide that has been used extensively for the control of Aedes albopictus and Aedes aegypti, the major vectors for viral diseases, such as dengue fever, zika and chikungunya. Resistance to temephos has been recently detected and associated with the upregulation of carboxylesterases (CCEs) through gene amplification, in both species. Here, we expressed the CCEae3a genes which showed the most striking up-regulation in resistant Aedes strains, using the baculovirus system. All CCEae3a variants encoded functional enzymes, with high activity and preference for p-nitrophenyl butyrate, a substrate that was shown capable to differentiate temephos resistant from susceptible Aedes larvae. Enzyme kinetic studies showed that CCEae3as from both Ae. aegypti and Ae. albopictus (CCEae3a_aeg and CCEae3a_alb, respectively) strongly interact with temephos oxon and slowly released the OP molecule, indicating a sequestration resistance mechanism. No difference was detected between resistant and susceptible CCEae3a_aeg variants (CCEae3a_aegR and CCEae3a_aegS, respectively), indicating that previously reported polymorphism is unlikely to play a role in temephos resistance. HPLC/MS showed that CCEae3as were able to metabolize temephos oxon to the temephos monoester [(4-hydroxyphenyl) sulfanyl] phenyl O,O-dimethylphosphorothioate. Western blot and immunolocalization studies, based on a specific antibody raised against the CCEae3a_alb showed that the enzyme is expressed at higher levels in resistant insects, primarily in malpighian tubules (MT) and nerve tissues.

  20. Prezident na bombardirovshtshike - ne sensatsija / Viktor Juzbashev

    Index Scriptorium Estoniae

    Juzbashev, Viktor

    2005-01-01

    Lääne pressis kommenteeriti Venemaa presidendi Vladimir Putini sõitu strateegilisel pommilennukil Tu-160 kui Venemaa surveavaldust naaberriikidele, samas viibivad ka teised riigijuhid aeg-ajalt sõjalistel objektidel ja taktikaõppustel. Autor küsib, kuidas Vene ja Hiina sõdurite ühisõppus saab olla tõsine hoiatus USA-le. Raketist X-555

  1. Tallinna sadamaala linnaruumiline arengukava : ettepanek = Urban Development Plan for the Tallinn Port Area : Proposal

    Index Scriptorium Estoniae

    2006-01-01

    Tellija: Tallinna Linnaplaneerimise Amet. Korraldaja: Eesti Arhitektide Liit. Aeg: 2006. a. veebruar. Osalejad: linnageograaf Hardo Aasmäe, arhitektid Andres Alver, Rein Hansberg, Veljo Kaasik, Ott Kadarik, Erik Konze, Margit Mutso, Tiit Sild, Villem Tomiste, TLPA juht, Tallinna peaarhitekt Igor Volkov, Tallinna Sadama esindaja Hannes Kuhlbach, TLPA projektijuht Jaan Kurm, TLPA üldplaneeringute osakonna juhataja Endrik Mänd, Logi Projekti esindaja Taimi Lokotar, Heldur Meerits

  2. Harimatuse mõrud viljad / Malle Salupere

    Index Scriptorium Estoniae

    Salupere, Malle, 1931-

    2006-01-01

    Ilmunud ka: Virumaa Teataja 11. juuli lk. 11. Autor avaldab arvamust Tõnismäe mälestussamba osas, tema sõnul on viimane aeg revideerida Eestis kinnistunud arusaama, nagu tuleneks Eesti liitmine NSVL-iga ainuüksi MRP-st, mitte samavõrdselt sellele eelnenud Müncheni sobingust ja järgnevatest Teherani-Jalta ning Potsdami salalepetest mõjusfääride jagamiseks

  3. Retreat - ehk kuidas äri- ja eraelu tasakaalu sättida / Anne-Liis Arulo

    Index Scriptorium Estoniae

    Arulo, Anne-Liis

    2004-01-01

    Retreat tähendab rühmatööd, kus võetakse aeg maha ja taandutakse argipäevast, et keskenduda iseenda tegevuse ja väliste protsesside analüüsiks, mõtete korrastamiseks ning väärtuste ja eesmärkide üle mõtlemiseks. Kommenteerivad Hardi Nigulas ja Arne Kaasik

  4. Fukuyama : kõigepealt hea valitsus, siis demokraatia ja ajaloo lõpp / Francis Fukuyama ; interv. Nathan Gardels

    Index Scriptorium Estoniae

    Fukuyama, Francis

    2005-01-01

    Francis Fukuyama sõnul vajab riik oma arenguks esmajoones head valitsemist. Kõige olulisem on, et oleks toimiv riik, mis suudab tagada julgeoleku ja majandusarengu elementaarsed tingimused. Iraagi praeguste probleemide põhjus on selles, et USA ei suutnud ette näha, kuidas riik Saddami kukkudes kokku variseb, kuid tuleb mõista, et aeg-ajalt on USA ja kogu maailma huvides kusagil maailma nurgas riigi ehitamine tõsiselt ette võtta, ütleb autor

  5. Surm kevadises Tallinnas ehk Kunstnike valuline reaktsioon meie ajale / Reet Varblane

    Index Scriptorium Estoniae

    Varblane, Reet, 1952-

    2006-01-01

    Mark Soosaare näitus "Aeg" Tallinna Kunstihoone galeriis kuni 23. IV, Jaan Paavle maalinäitus "1 minut" 3.-15. IV Draakoni galeriis, Sandra Jõgeva ja Kristin Kalamehe "Leave like a Lady" Draakoni galerii keldrisaalis 4.-15. IV, Marianne Männi näitus "Paradiis" Hobusepea galeriis 5.-17. IV. Maailma positiivsemale poolusele osutab 20. IV Tallinna Linnagaleriis avatud Mari ja Kaarel Kurismaa ruumiinstallatsioon "Teine süütus"

  6. "ta surnud sõbrad..." : [luuletused] / Caspar Tops

    Index Scriptorium Estoniae

    Tops, Caspar

    2002-01-01

    Autorist lk 133. Sisu: "ta surnud sõbrad..." ; "ta kummaline hüüd..." ; "nii salakaval oli üks naine..." ; "ta tõmbas..." ; "mul meeles üks..." ; "rohi saab lahti iga päev üha..." ; "aeg riietab end lahti..." ; "ta kunagi..." ; "me riietume..." ; "ma tean armastuse põsepuna..." ; "kunas see suudlus..." ; "sina mu mälestuste tydruk..." ; "su õde mind armastas..." ; "hingata valutult..." ; "need juuksed pesemata..." ; "ah saab olema..." ; "siit natuke maad edasi..."

  7. Teadus- ja erialaraamatukogudel oma päev ja aasta teo auhind / Kristina Rallmann

    Index Scriptorium Estoniae

    Rallmann, Kristina

    2008-01-01

    Esimene teadus- ja erialaraamatukogude päev toimus 22. oktoobril 2008 Tallinna majanduskoolis, teadusraamatukogu aasta teo auhind läks RR-i virtuaaalnäitusele "Meie parlament ja aeg: fakte, sündmusi, dokumente, inimesi" ning erialaraamatukogu aasta teo auhind Eesti Pimedate Raamatukogu töörühmale heliteavikute CD-plaatidele automatiseeritud paljundamise ja posti teel laenutamise süsteemi eest

  8. 20. X avati arhitektuuri- ja disainigaleriis...

    Index Scriptorium Estoniae

    2004-01-01

    Väljapanek "Vaateaken Eesti ekspositsioonile Veneetsia arhitektuuribiennaalil". Eestit esindab 9. Veneetsia arhitektuuribiennaalil Eesti Arhitektide Liidu projekt "Aeg-maha-arhitektuur", idee autor Kristjan Holm, kaasautorid Liina Jänes ja Pille Epner. Kabli rannast Veneetsiasse teisaldatud puust hobusekujulise välikäimla on loonud Agu Külm ja Jukka-Pekka Jalovaara. Ku-Ku klubis esilinastus Marianne Kõrveri, Rain Tolgi ja Andres Maimiku dokumentaalfilm "Surm Veneetsias"

  9. Rossii ne nuzhna milost Zapada / Jonathan Steele

    Index Scriptorium Estoniae

    Steele, Jonathan

    2007-01-01

    Autori hinnangul on Vladimir Putin andnud Venemaale sõltumatuse ja uue rolli rahvusvahelisel areenil. Aeg, mil Läänel oli võimalus avaldada mõju Venemaa sisemisele arengule, on möödas. Tuleb leppida Venemaa sõltumatusega ning mõista, et Venemaasse tuleb suhtuda vähemalt nii, nagu suhtutakse Hiinasse - kui majanduslikku ja strateegilisse giganti

  10. Identification of Novel Recombinant Forms of Hepatitis B Virus Generated from Genotypes Ae and G in HIV-1-Positive Japanese Men Who Have Sex with Men.

    Science.gov (United States)

    Kojima, Yoko; Kawahata, Takuya; Mori, Haruyo; Furubayashi, Keiichi; Taniguchi, Yasushi; Itoda, Ichiro; Komano, Jun

    2015-07-01

    The rare hepatitis B virus (HBV) genotype G (HBV/G) coinfects HIV-1-positive individuals along with HBV/A and generates recombinants. However, the circulation of HBV A/G recombinants remains poorly understood. This molecular epidemiologic study examined HBV A/G recombinants in Japanese HIV-1-positive men who have sex with men (MSM). Initially, blood specimens submitted for confirmatory tests of HIV infection in Osaka and Tokyo, Japan, from 2006 to 2013 were examined for HIV-1, and HIV-1-positive specimens were screened for HBV. Among 817 specimens from HIV-1-positive individuals, HBsAg was detected in 59 specimens; of these, HBV/Ae (alternatively A2), a subgenotype of HBV/A prevalent in Europe and North America, was identified in 70.2%, HBV/C in 17.5%, and HBV/G in 10.5%, and HBV/E in 1.8% according to the core gene sequence. The full-length genome analysis of HBV was performed on HBV/G-positive specimens because some HBV A/G recombinants were historically overlooked by genotyping based on a partial genome analysis. It revealed that five of the specimens contained novel Ae/G recombinants, the core gene of which had a high sequence similarity to HBV/G. Detailed analyses showed that novel recombinants were coinfected with HBV/Ae in a recombinant-dominant fashion. No major drug-resistant mutations were found in the newly identified HBV Ae/G recombinants. Some of the individuals asymptomatically coinfected with HIV/HBV suffered mild liver injury. This study demonstrated that novel Ae/G HBV recombinants were identified in Japanese HIV-1-positive MSM. The pathogenicity of novel HBV Ae/G recombinants should be examined in a future longitudinal study. Surveillance of such viruses in HIV-1-positive individuals should be emphasized.

  11. Analüütikud soovitavad Eesti Energia börsile viia / Piret Reiljan

    Index Scriptorium Estoniae

    Reiljan, Piret, 1983-

    2008-01-01

    Kohalikud analüütikud soovitavad viia Eesti Energia börsile, kuna see elavdaks aktsiaturgu ja tõmbaks ligi välisinvestoreid. Vt. samas: Raivo Vare: raske aeg töötab Eesti Energia börsiletoomise kasuks; Analüüs ootab pääsu valitsuskabinetti; Juhid ei püsi enam Eesti Energias. Diagrammid: Majandusnäitajad; Varade maht

  12. Čiurlionis oma ja praeguses ajas / Mai Levin

    Index Scriptorium Estoniae

    Levin, Mai, 1942-

    2010-01-01

    Näitus "Čiurlionis ja tema aeg leedu kunstis" Kumu Kunstimuuseumis 8. augustini 2010. Näituse on koostanud Kaunase Riiklik M. K. Čiurlionise Kunstimuuseum, kuraatorid Kristina Daubarytė ja Mai Levin, kujundaja Mari Kurismaa. 13. mail toimunud seminarist. Leedu ja eesti kunstnike kontaktidest, ühis- ja vahetusnäitustest, Aleksis Ranniti rollist Čiurlionise propageerijana Läänes, Čiurlionise mõjudest

  13. Maailmas pole enam ühtki riski? / Jonathan Compton ; tõlk. Villu Zirnask

    Index Scriptorium Estoniae

    Compton, Jonathan

    2006-01-01

    Autori sõnul on aktsia- ja võlakirjaturud hinnanud sõjaväelist riigipööret Tais ja Põhja-Korea saamist tuumariigiks triviaalseteks ja globaalseid riske vähendavaks. Riski hind näib praegusel ajal olevat pöördvõrdelises seoses olukorraga riigis. Kindel on, et praegu on ohtlik aeg osta arenevate turgude võlakirju, osta Bulgaaria kinnisvara, riskifondide fonde, indeksifonde ja muid investeeringuid

  14. Pesakastide jaoks jääb võimsust ülegi / Rakennusmaailma põhjal Ingrid Maasik

    Index Scriptorium Estoniae

    2011-01-01

    10,8- ja 12voldised akutrell-kruvikeerajad: AEG BS 12 C 2, Biltema 17-275, Black&Decker HPL106K, Bosch GSR 10,8-Li-2, DeWalt DCD710, Einhell BT-CD, Festool CXS, Festool C12Li, Hitachi DS 10 DFL, Makita DF330D, Metabo PowerMaxx 12, Milwaukee C12DD-32C, Nutool 10,8V, Panasonic EY6409

  15. Aitab hädaldamisest / Robert Antropov

    Index Scriptorium Estoniae

    Antropov, Robert, 1965-

    2006-01-01

    Endine politseijuht on seisukohal, et politseinike ja päästjate nappuses ei saa süüdistada ainult väikseid palku, küsimus on valikutes: kuidas ja millesse ressursse paigutada. Kalle Laanet ja Raivo Aeg vastavad küsimusele, mis on nende haldusalas konkreetselt kavas, et politsei saaks täita oma tegevusprioriteeti 100% ja tagada sisejulgeoleku. Vt. ka Robert Antropovi kommentaari 7. aug. Eesti Päevaleht lk. 2

  16. AcEST: DK962893 [AcEST

    Lifescience Database Archive (English)

    Full Text Available =Mus mu... 31 4.4 sp|P10388|GLT5_WHEAT Glutenin, high molecular weight subunit DX5... 31 5.8 sp|P08489|GLT4_WHEAT Gluten... RGG A AEG Sbjct: 87 DPGTGIKTKAVSVGEAGGAGDPGAAAG---DSLRGGMATAEG 125 >sp|P10388|GLT5_WHEAT Gluten...SGQGQQGYYSSYHVSVEH 806 >sp|P08489|GLT4_WHEAT Glutenin, high molecular weight subu

  17. AcEST: DK950302 [AcEST

    Lifescience Database Archive (English)

    Full Text Available OS=Mus mu... 31 5.2 sp|P10388|GLT5_WHEAT Glutenin, high molecular weight subunit DX5... 30 8.8 sp|P08489|GLT4_WHEAT Gluten... G GI+ +A S+ + GG G+ G D+ RGG A AEG Sbjct: 87 DPGTGIKTKAVSVGEAGGAGDPGAAAG---DSLRGGMATAEG 125 >sp|P10388|GLT5_WHEAT Gluten...QQGYYPTSLQQTGQGQQSGQGQQGYYSSYHVSVEH 806 >sp|P08489|GLT4_WHEAT Glutenin, high molecular weight subunit PW212

  18. Ülekaalukalt suurima toetusega Toomas Hendrik Ilves tõusis rahva uueks lemmikuks üleöö / Kai Kalamees

    Index Scriptorium Estoniae

    Kalamees, Kai

    2006-01-01

    Eesti Päevalehe tellitud ja Turu-uuringute AS-i läbiviidud küsitlusest presidendikandidaatide toetuse kohta. Vt. samas: Mida aeg edasi, seda enam soositakse Ilvest. Kommenteerib Tõnis Ormisson Turu-uuringute ASist; Soosaar: edasine sõltub Ilvesest. Poliitikavaatleja Enn Soosaar põhjendab T. H. Ilvese suurt ülekaalu tema välispoliitilise võimekusega; Rüütel vihjas valimiskogule. Diagramm

  19. Methodological Issues in Research on Reading Text with Illustrations.

    Science.gov (United States)

    1981-02-01

    less equal black and white spaces. 8. Writing has various forms that are not usually ixed. A text may be handwritten, typed, printed, cursive, capitals ...and lowercase, etc. lot all writing systems have the same variations. Styles are mixed only for conventional reasons, as capitals at the beginning of...Alan Losgold I Dr. * br,9l bugles Loarulag an center. Deprment of Psycology nIlversity ot Pittsburgh University of aeges P11411Wgh. PA 151 Sues 081

  20. Lugusid möödunud aegadest / Andrus Kivirähk

    Index Scriptorium Estoniae

    Kivirähk, Andrus, 1970-

    2007-01-01

    Autor toob viimasel ajal loetud kirjandusteoste hulgast välja oma põnevaimad leiud: Mart Kivastik. Külmetava kunstniku portree ; Mart Kivastik. Põrgu wärk ; Mart Kivastik. Kits õnge ja viiuliga ; Galina Vishnevskaja. Aeg ja elu ; Maurice Druon. Neetud kuningad : raudne kuningas ; Maurice Druon. Neetud kuningad : kägistatud kuninganna ; Maurice Druon. Neetud kuningad : kuningavõimu mürgitajad

  1. Ventricular activity cancellation in electrograms during atrial fibrillation with constraints on residuals' power.

    Science.gov (United States)

    Corino, Valentina D A; Rivolta, Massimo W; Sassi, Roberto; Lombardi, Federico; Mainardi, Luca T

    2013-12-01

    During atrial fibrillation (AF), cancellation of ventricular activity from atrial electrograms (AEG) is commonly performed by template matching and subtraction (TMS): a running template, built in correspondence of QRSs, is subtracted from the AEG to uncover atrial activity (AA). However, TMS can produce poor cancellation, leaving high-power residues. In this study, we propose to modulate the templates before subtraction, in order to make the residuals as similar as possible to the nearby atrial activity, avoiding high-power ones. The coefficients used to modulate the template are estimated by maximizing, via Multi-swarm Particle Swarm Optimization, a fitness function. The modulated TMS method (mTMS) was tested on synthetic and real AEGs. Cancellation performances were assessed using: normalized mean squared error (NMSE, computed on simulated data only), reduction of ventricular activity (VDR), and percentage of segments (PP) whose power was outside the standard range of the atrial power. All testings suggested that mTMS is an improvement over TMS alone, being, on simulated data, NMSE and PP significantly decreased while VDR significantly increased. Similar results were obtained on real electrograms (median values of CS1 recordings PP: 2.44 vs. 0.38 p < 0.001; VDR: 6.71 vs. 8.15 p < 0.001).

  2. Lymph node dissection for Siewert II esophagogastric junction adenocarcinoma

    Science.gov (United States)

    Duan, Xiao-Feng; Yue, Jie; Tang, Peng; Shang, Xiao-Bin; Jiang, Hong-Jing; Yu, Zhen-Tao

    2017-01-01

    Abstract The present study was aimed to investigate the application of right thansthoracic Ivor–Lewis (IL), left transthoracic (LTT), and left thoracoabdominal (LTA) approach in Siewert type II adenocarcinoma of esophagogastric junction (AEG). The data of 196 patients with Siewert type II AEG received surgical resection in our cancer center between January 2014 and April 2016 was retrospectively analyzed. Finally, 136 patients met the inclusion criteria were enrolled in the study and divided into the IL (47 cases), LTT (51 cases), and LTA group (38 cases). Clinical and short-term treatment effects were compared among the 3 groups. The patients with weight loss, diabetes, and heart disease increased in the LTT group (P = 0.054, P = 0.075, and P = 0.063, respectively). Operation time was significantly longest in the IL group (P  0.05), but the dissection rate of the hepatic artery, splenic artery, and celiac trunk lymph nodes was significantly highest in the IL group (P  0.05). Compared with the traditional left transthoracic approach, the Ivor–Lewis approach did not increase the perioperative mortality and complication rates in Siewert type II AEG, but obtained satisfactory length of the proximal surgical margin, and was better than the left transthoracic approach in thoracic and abdominal lymph node dissection. However, the advantages of Ivor–Lewis procedure requires further follow-up and validation through prospective randomized controlled trials. PMID:28207537

  3. Preliminary research on regulatory effect of estrogen on malignant biological behaviors of triple-negative breast cancer cells and its molecular mechanisms

    Institute of Scientific and Technical Information of China (English)

    Tian-Fang Zhou

    2016-01-01

    Objective:To study the regulating effect of estrogen on malignant biological behaviors of triple-negative breast cancer cells and its molecular mechanisms. Methods:Triple-negative breast cancer cell lines MDA-MB-468 were cultured and treated with different doses of estrogen and 10-6 mol/L estrogen combined with GPR30 antagonist G15 for 12 h, 24 h and 48 h, and then cell viability, migration as well as mRNA expression levels of ITGβ1, Sema 4D, MK, c-Met and AEG-1 were detected. Results:Estradiol could increase cell viability, reduce scratch area and increase mRNA expression levels of ITGβ1, Sema 4D, MK, c-Met and AEG-1 in dose-dependent and time-dependent manner;after estradiol combined with G15 treatment, cell viability was significantly lower than that of estradiol treatment alone, scratch area was significantly larger than that of estradiol treatment alone, and mRNA contents of ITGβ1, Sema 4D, MK, c-Met and AEG-1 were significantly lower than those of estradiol treatment alone. Conclusion:Estrogen can regulate the malignant biological behaviors of triple-negative breast cancer cells, promote cell proliferation and migration, and increase the expression of related genes through GPR30.

  4. Synthesis and NMR studies of malonyl-linked glycoconjugates of N-(2-aminoethylglycine. Building blocks for the construction of combinatorial glycopeptide libraries

    Directory of Open Access Journals (Sweden)

    Markus Nörrlinger

    2016-08-01

    Full Text Available Four glycoconjugate building blocks for the construction of combinatorial PNA like glycopeptide libraries were prepared in 75–79% yield by condensing tert-butyl N-[2-(N-9-fluorenylmethoxycarbonylaminoethyl]glycinate (AEG 5 with 3-oxo-3-(2,3,4,6-tetra-O-acetyl-β-D-glucopyranosylamino- (6a, 3-oxo-3-(β-D-galactopyranosylamino- (6b, 3-oxo-3-(2-acetamido-2-deoxy-3,4,6-tetra-O-acetyl-β-D-glucopyranosylamino- (6c and 3-oxo-3-(2-acetamido-2-deoxy-3,4,6-tetra-O-acetyl-β-D-galactopyranosylaminopropanoic acid (6d, respectively. The resulting AEG glycoconjugates 1a–d were converted into the corresponding free acids 2a–d in 97–98% yield by treatment with aqueous formic acid. The Fmoc group of compound 1c was removed and the intermediate amine 9 was condensed with 2a to afford the corresponding glycosylated AEG dipeptide 4 in 58% yield. All glycoconjugate building blocks showed the presence of cis and trans rotamers. Compounds 1a, 1b and 4 were subjected to temperature dependent 1H NMR spectroscopy in order to determine the coalescence temperature which resulted in calculated rotation barriers of 17.9–18.3 kcal/mol for the rotamers.

  5. High performance asymmetric supercapacitor based on molybdenum disulphide/graphene foam and activated carbon from expanded graphite.

    Science.gov (United States)

    Masikhwa, Tshifhiwa M; Madito, Moshawe J; Bello, Abdulhakeem; Dangbegnon, Julien K; Manyala, Ncholu

    2017-02-15

    Molybdenum disulphide which has a graphene-like single layer structure has excellent mechanical and electrical properties and unique morphology, which might be used with graphene foam as composite in supercapacitor applications. In this work, Molybdenum disulphide (MoS2)/graphene foam (GF) composites with different graphene foam loading were synthesized by the hydrothermal process to improve on specific capacitance of the composites. Asymmetric supercapacitor device was fabricated using the best performing MoS2/GF composite and activated carbon derived from expanded graphite (AEG) as positive and negative electrodes, respectively, in 6M KOH electrolyte. The asymmetric MoS2/GF//AEG device exhibited a maximum specific capacitance of 59Fg(-1) at a current density of 1Ag(-1) with maximum energy and power densities of 16Whkg(-1) and 758Wkg(-1), respectively. The supercapacitor also exhibited a good cyclic stability with 95% capacitance retention over 2000 constant charge-discharge cycles. The results obtained demonstrate the potential of MoS2/GF//AEG as a promising material for electrochemical energy storage application.

  6. Iirimaale : [luuletused] / Percy Bysshe Shelley ; tlk. Minni Nurme, Ants, Oras

    Index Scriptorium Estoniae

    Shelley, Percy Bysshe

    2006-01-01

    Sisu: Iirimaale ; Armastuse roos ; Harrietile ; Muutlikkus ; Vangist vabanenud sõbrale ; Minevik ; Byronile ; Kaduvik ; Laul : "Maa magas, külm kui surm..." ; Hümn vaimsele ilule ; Laul : "Too aeg on läind, mu armsam, läind..." ; Ozymandias ; Sonett ; India serenaad ; Leonardo da Vinci Medusa Firenze kunstikogus ; Armu filosoofia ; Ood läänetuulele ; Mary Shelleyle ; Laul briti meestele ; Uus rahvushümn ; Inglismaa 1819. a. ; Ära madu ärata ; Head ööd! ; Pilv ; Apolloni hümn ; Paani hümn ; Lõoke ; Vabadus ; Suvi ja talv ; Maailmarändurid ; Küsimus ; Aeg, mis hajus ; Ööle ; -le : "Üht sõna on labastand suud..." ; -le : "Kui kirg kord mööduks, aga jääks..." ; Õhtu Ponte al Marel, Pisas ; Mälestus ; Muusika ; Aeg ; Põgenejad ; Ma olla kuningas ei tahaks ; "Homne päev, kus oled praegu..." ; "Laps rahus kord on emaihus..." ; Üksik lind ; "Kui lamp pihuks langend..." ; Epitaaf ; Kutse Janeþile ; Tähed vilkusid valgust ; Leinalaul ; Pühendus. Eluloolisi andmeid autori kohta lk. 389

  7. Application of Alkylethoxyglucoside in Pesticide Microemulsion%醇醚糖苷在农药微乳液中的应用

    Institute of Scientific and Technical Information of China (English)

    朱福送; 杨秀全; 白亮; 樊文俊; 张军

    2011-01-01

    [目的]醇醚糖苷(AEG)是一种新型绿色功能性表面活性剂,在农药制剂中尚少有应用.研制含醇醚糖苷的啶虫脒微乳液,并将其与常规的乳油制剂做润湿力、动态接触角和药液沉积量对比试验,考察醇醚糖苷在农药制剂中应用的实际效果及可行性.[结果]通过溶剂、表面活性剂复配的筛选及拟三元相图的绘制,确定了以醇醚糖苷与十二烷基苯磺酸钠(LAS)复配作乳化剂,制备了3%和5%啶虫脒微乳液.与常规的乳油制剂相比,用醇醚糖苷制备的微乳液表面活性剂用量低,润湿性和药液沉积量优于同类乳油产品.[结论]醇醚糖苷性能优越,可作为农药乳化剂和增效剂使用.%[Aims] Alkylethoxyglucoside (AEG) is a new biodegradable functional surfactants, and still rarely be applied in pesticide formulations. Here, the formulation of acetamiprid microemulsion containing AEG was prepared and compared to conventional EC formulation on wetting properity, dynamic contact angle and pesticide solution retention to study the actual effect and feasibility evaluation of application of alkylethoxyglucoside in pesticide formulations. [Results] By optimizing the solvents, surfactants systems and drawing pseudoternary phase diagram, the formulation of acetamiprid 3 and 5% microemulsion was prepared using the compounded system of AEG and LAS as emulsifier. As compared to the common EC formulation, the acetamiprid microemusion prepared by AEG consumed less amount of surfactants, possessed better wetting properity and larger pesticide solution retention. [Conclusions] Alkylethoxyglucoside has superior performance, and can be used as a new pesticide emulsifier and synergist.

  8. Effect of commercial long-term extenders on metabolic activity and membrane integrity of boar spermatozoa stored at 17 degrees C.

    Science.gov (United States)

    Dziekońska, A; Fraser, L; Majewska, A; Lecewicz, M; Zasiadczyk, Ł; Kordan, W

    2013-01-01

    This study was aimed to analyze the metabolic activity and membrane integrity of boar spermatozoa following storage in long-term semen extenders. Boar semen was diluted with Androhep EnduraGuard (AeG), DILU-Cell (DC), SafeCell Plus (SCP) and Vitasem LD (VLD) extenders and stored for 10 days at 17 degrees C. Parameters of the analyzed sperm metabolic activity included total motility (TMOT), progressive motility (PMOT), high mitochondrial membrane potential (MMP) and ATP content, whereas those of the membrane integrity included plasma membrane integrity (PMI) and normal apical ridge (NAR) acrosome. Extender type was a significant (P sperm parameters, except for ATP content. Furthermore, the storage time had a significant effect (P sperm metabolic activity and membrane integrity during semen storage. In all extenders the metabolic activity and membrane integrity of the stored spermatozoa decreased continuously over time. Among the four analyzed extenders, AeG and SCP showed the best performance in terms of TMOT and PMI on Days 5, 7 and 10 of storage. Marked differences in the proportions of spermatozoa with high MMP were observed between the extenders, particularly on Day 10 of storage. There were not any marked differences in sperm ATP content between the extenders, regardless of the storage time. Furthermore, the percentage of spermatozoa with NAR acrosomes decreased during prolonged storage, being markedly lower in DC-diluted semen compared with semen diluted with either AeG or SCP extender. The results of this study indicated that components of the long-term extenders have different effects on the sperm functionality and prolonged semen longevity by delaying the processes associated with sperm ageing during liquid storage.

  9. Arterial Stiffness by Aerobic Exercise Is Related with Aerobic Capacity, Physical Activity Energy Expenditure and Total Fat but not with Insulin Sensitivity in Obese Female Patients with Type 2 Diabetes

    Directory of Open Access Journals (Sweden)

    Ji Yeon Jung

    2014-12-01

    Full Text Available BackgroundArterial stiffness is an important factor in atherosclerosis. Thus we examined whether aerobic exercise could reduce arterial stiffness in obese women with type 2 diabetes without diabetic complication.MethodsA total of 35 women with type 2 diabetes (body mass index, 26.6±2.8 kg/m2; age, 56.4±1.9 years; duration of diabetes, 4.7±4.8 years were assigned to aerobic exercise group (AEG or control group (CG. AEG completed a 12-week exercise program (3.6 to 5.2 metabolic equivalents, 3 day/week, 60 min/day, with their exercise activities monitored by accelerometers. We measured abdominal total fat area (TFA, visceral fat area (VFA, and subcutaneous fat area (SFA by computed tomography, insulin sensitivity by insulin tolerance test (KITT, and augmentation index (AIx by SphygmoCor at baseline and at the end of the 12-week program.ResultsThe AIx was improved in the AEG compared with the CG (P<0.001. The percent change of AIx had significant correlation with the improvement of physical activity energy expenditure (PAEE, aerobic capacity, TFA, and SFA (r=-0.416, P=0.013; r=0.560, P<0.001; r=0.489, P=0.003; r=0.531, P=0.001, respectively, but not with insulin sensitivity, energy intake, or VFA.ConclusionImprovement in aortic stiffness by aerobic exercise is related with the improvement of aerobic capacity, PAEE, and total fat but not with insulin sensitivity or energy intake in obese women with type 2 diabetes.

  10. Perioperative nutrition support of adenocarcinoma of the esophagogastric junction%食管胃结合部腺癌围手术期营养支持

    Institute of Scientific and Technical Information of China (English)

    王强; 赵毅

    2012-01-01

    食管胃结合部是指食管末段和近侧胃相连接的部位.食管胃结合部腺癌(AEG)作为一类不同于食管癌和胃癌的独立疾病的临床观点已经被多数学者所接受.然而AEG的围手术期营养支持特点及选择还需进一步研究、探讨.AEG病人常有不同程度的营养不良和免疫功能低下,围手术期合理应用肠内、肠外营养支持对AEG术后病人减少并发症,促进恢复有重要的作用.%The primary treatment of adenocarcinoma of theesophagogastric junction (AEG) is surgery, but more than 50% of curatively resected patients undergo recurrence or cancer-related death during postoperative 5 years. It implies multidisciplinary treatment of radio- and chemotherapy is still necessary. Recently, neoadjuvant therapy has been paid more attention to, and neoadjuvant radiotherapy is currently considered able to improve 5-year overall survival. Moreover, European Organization for Research and Treatment of Cancer has made a consensus guideline of neoadjuvant radiotherapy for AEG, which is useful in clinical practice. Neoadjuvant chemotherapy is meaningful to increase R0 resection rate, but should combine adjuvant chemotherapy to improve overall survival. Concept on adjuvant chemotherapy is according to gastric cancer, and NCCN guideline recommends classic ECF or modified ECF regimens. Results of monotherapy SI trial also showed improved overall survival. The evidence of intra-or postoperative radiotherapy is poor and can not improve long term survival. Therefore, preoperative concurrent chemoradiotherapy plus postoperative chemotherapy is currently preferable multidisciplinary treatment model.

  11. Lymph node ratio-based staging system as an alternative to the current TNM staging system to assess outcome in adenocarcinoma of the esophagogastric junction after surgical resection.

    Science.gov (United States)

    Zhang, Hongdian; Shang, Xiaobin; Chen, Chuangui; Gao, Yongyin; Xiao, Xiangming; Tang, Peng; Duan, Xiaofeng; Yang, Mingjian; Jiang, Hongjing; Yu, Zhentao

    2016-11-08

    This study aimed to assess the prognostic value of the hypothetical tumor-N-ratio (rN)-metastasis (TrNM) staging system in adenocarcinoma of the esophagogastric junction (AEG). The clinical data of 387 AEG patients who received surgical resection were retrospectively reviewed. The optimal cut-off point of rN was calculated by the best cut-off approach using log-rank test. Kaplan-Meier plots and Cox regressions model were applied for univariate and multivariate survival analyses. A TrNM staging system based on rN was proposed. The discriminating ability of each staging was evaluated by using an adjusted hazard ratio (HR) and a -2log likelihood. The prediction accuracy of the model was assessed by using the area under the curve (AUC) and the Harrell's C-index. The number of examined lymph nodes (LNs) was correlated with metastatic LNs (r = 0.322, P 0.05). The optimal cut-points of rN were calculated as 0, 0~0.3, 0.3~0.6, and 0.6~1.0. Univariate analysis revealed that pN and rN classifications significantly influenced patients' RFS and OS (P analysis adjusted for significant factors revealed that rN was recognized as an independent risk factor. A larger HR, a smaller -2log likelihood and a larger prediction accuracy were obtained for rN and the modified TrNM staging system. Taken together, our study demonstrates that the proposed N-ratio-based TrNM staging system is more reliable than the TNM staging system in evaluating prognosis of AEG patients after curative resection.

  12. Carcinoembryonic antigens are targeted by diverse strains of typable and non-typable Haemophilus influenzae.

    Science.gov (United States)

    Virji, M; Evans, D; Griffith, J; Hill, D; Serino, L; Hadfield, A; Watt, S M

    2000-05-01

    Haemophilus influenzae (Hi), a commensal of the human respiratory mucosa, is an important cause of localized and systemic infections. We show that distinct strains belonging to typable (THi) and non-typable (NTHi) H. influenzae target human carcinoembryonic antigens (the membrane associated CEA family of cell adhesion molecules, are now termed CEACAMs). All strains of H. influenzae biogroup aegyptius (Hi-aeg) and more than 70% of THi and NTHi strains tested specifically recognize CEACAMI-Fc soluble constructs. Furthermore, transfection of Chinese hamster ovary cells with human CEACAM1 cDNA alone was sufficient for promoting Hi interactions with the transfected cells. The majority of the Hi-aeg strains tested interacted with soluble constructs containing only the N-terminal domain. In contrast, several THi and NTHi strains reacted with soluble constructs only when additional extracellular A and B domains of the receptor were present. The use of monoclonal antibodies confirmed that THi and NTHi strains also interact primarily at the N-domain. We used site-directed mutants of CEACAM1 that contained substitutions at surface exposed amino acids and a molecular model of the N-domain to identify the residues involved in interactions with Hi ligands. The studies show that a common region exposed at the CFG face of the molecule is targeted by diverse Hi strains. However, mutation at distinct sites within this area affected the interactions of distinct strains signifying the potential for tissue tropism via this receptor. Analyses of the molecular basis of interaction with human cell lines and purified CEA show that Hi strains, especially those belonging to Hi-aeg, interact with multiple CEACAMs. Because Neisseria meningitidis (Nm) strains are also known to bind at the CFG face of the receptor, we used Nm and Hi strains in co-infection experiments and demonstrate competition between these mucosal pathogens in colonization of target cells via CEACAMs.

  13. 乌饭树树叶水提取物改善糖尿病小鼠血糖和血脂水平的研究%Effect of Vaccinium bracteatum Thunb.leaves aqueous extract on blood glucose and plasma lipid levels in streptozotocin-induced diabetic mice

    Institute of Scientific and Technical Information of China (English)

    王立; 张雪彤; 章海燕; 程素娇; 钱海峰; 张晖; 张英

    2012-01-01

    The hypoglycemic effects of Vaccinium bracteatum Thunb.leaves(VBTL) aqueous extract in streptozotocin-induced diabetic mice was studied.The aqueous extract of VBTL showed obviously hypoglycemic and hypolipidemic effects,but the effects were weaker than those of dimethylbiguanide.Compared with diabetic mice in model control group,body weights of aqueous extract group(AEG,diabetic mice treated with VBTL aqueous extract) were partly recovered.The BG levels of AEG were reduced 14.2%,and body weights were increased 61.0%.AEG had significantly lower(p0.05) TC or TG levels and similar HDL-cholesterol or LDL-cholesterol levels.In conclusion,research clearly indicated that the aqueous extract of VBTL possess a potential hypoglycemic effect in streptozotocin-induced diabetic mice.%以链脲佐菌素造模糖尿病小鼠为研究对象,对乌饭树树叶水提取物的降血糖和血脂作用进行了研究,并与二甲双胍的效果进行了比较。结果表明,虽然效果没有二甲双胍明显,但水提物对糖尿病小鼠的血糖和血脂有明显的改善作用。相对模型对照组,灌胃四周水提物后糖尿病小鼠的体重增加了61.0%,血糖降低了14.2%,血脂水平也得到了明显的改善。

  14. Suvi tulvil festivale

    Index Scriptorium Estoniae

    2005-01-01

    Suvel toimuvate musikafestivalide tutvustus: Eduard Tubin ja tema aeg (muusikafestival), Pärnu rahvusvaheline ooperimuusika festival 2005, Juu Jääb 2005 (retromuusikafestival), Suure-Jaani muusikapäevad 2005, Mravinski Festival 2005, Seitsme linna muusika 2005, Hiiumaa kammermuusikapäevad 2005, Saaremaa suvemuusikafestival 2005, David Oistrahhi festival 2005, Klaaspärlimäng (festival) 2005, Rapla kirikumuusika XIII festival 2005, Kuressaare ooperipäevad 2005, Pärnu ooperipäevad 2005, Tallinna XIX orelifestival, Haapsalu XII viiulimängud 2005, Viljandi vanamuusikafestival 2005, Kuressaare kammermuusikapäevad 2005, Haapsalu vanamuusikafestival 2005, Võru Muusikapäevad 2005

  15. Pärast meid tulgu või veeuputus / Andrus Villem

    Index Scriptorium Estoniae

    Villem, Andrus

    2006-01-01

    Ilmunud ka: Lääne Elu, Koit, Meie Maa 18. juuli lk. 2,6,2, Sõnumitooja 19. juuli lk. 2, Sakala, Vooremaa 20. juuli lk. 2, Harjumaa 21. juuli lk. 2, Virumaa Teataja, Hiiu Leht 25. juuli lk. 11,2, Põhjarannik, Severnoje Poberezhje 2. aug. lk. 2, Järva Teataja 3. aug. lk. 2. Autor leiab, et siiani on Eesti riigivalitsejad lähtunud oma tegevuses hetkepoliitilistest kaalutlustest, praegu on võimulolijatel viimane aeg välja töötada aastakümneid ette vaatavad tegevuskavad, mis aitavad lisaks majanduslikule vundamendile luua ka sotsiaalse. Lisa: Arvamus

  16. Eesti Teadusfondi preemia Astrid Haljasele ja Tõnu Laasile

    Index Scriptorium Estoniae

    2000-01-01

    Eesti Teadusfondi täppisteaduste ekspertkomisjoni poolt korraldatud magistrantide ja doktorantide teadustööde konkursil määrati preemia 4000 krooni loodusteaduste osakonna teadurile Astrid Haljasele artikli Mankin, R., Ainsaar, A., Haljas, A. Trichotomous-noise-induced phase transitions for the stochastic Hongler model. Proc. Estonian Acad. Sci. Phys. Math., 2000, 49, 1, 28-39 eest. Loodusteaduste osakonna assistendile, TPÜ doktorandile Tõnu Laasile määrati preemia 7000 krooni artiklite sarja Lainete levik kõveras aeg-ruumis eest : [täistekst

  17. Trumbid on Keskerakonna käes / Andrus Villem

    Index Scriptorium Estoniae

    Villem, Andrus

    2004-01-01

    Ilmunud ka: Elva Postipoiss, 4. dets. 2004, lk. 4; Lääne Elu, 7. dets. 2004, lk. 2; Järva Teataja, 7. dets. 2004, lk. 2; Harjumaa, 7. dets. 2004, lk. 2; Vooremaa, 7. dets. 2004, lk. 2; Koit, 7. dets. 2004, lk. 6; Pärnu Postimees, 8. dets. 2004, lk. 15; Sakala, 8. dets. 2004, lk. 2; Hiiu Leht, 10. dets. 2004, lk. 2; Kesknädal, 15. dets. 2004, lk. 11. Autor leiab, et praeguse koosseisuga koalitsiooni aeg on läbi ning hetkel on Keskerakond parimas olukorras

  18. The new Class 611 diesel railcar with active tilting technology; Der neue Dieseltriebzug Baureihe 611 mit aktiver Neigetechnik

    Energy Technology Data Exchange (ETDEWEB)

    Sauer, B.; Schoenberg, S; Waetzold, S. [ABB Daimler-Benz Transportation GmbH, Henningsdorf (Germany)

    1996-06-01

    Starting with the successful Class 610, AEG Schienenfahrzeuge GmbH has been developing and building a new vehicle class with the AEG neicontrol-E active tilt technology - the Class 611. Deutsche Bahn AG has ordered 50 railcars, of which the first go into service in spring 1996. They will operate on lines that are mostly non-electrified and have frequent curves and they will run at up to 160 km/h. The new design incorporates much expertise derived from the building and operation of the VT 610, the result being a vehicle that meets the requirements of passenger- and environment-friendliness and is also easy to maintain and is economical. The electrical tilting technology has been jointly developed by AEG Schienenfahrzeuge and the Daimler-Benz subsidiary ESW. A space-saving arrangement underfloor was chosen, and it is also low in weight and largely maintenance-free. The components used have proved themselves over many years in military applications under extreme climatic conditions. (orig.) [Deutsch] Aufbauend auf der bewaehrten Baureihe 610 entwickelt und baut die ABB Daimler-Benz Transportation (Deutschland) GmbH eine neue Generation von Fahrzeugen mit der aktiven elektrischen Neigetechnik AEG neicontrol-E - die Baureihe 611. Adtranz baut unter Beteiligung der DWA 50 Triebzuege fuer die Deutsche Bahn AG, von denen die ersten im Fruehjahr 1996 in Betrieb gesetzt werden. Die Einsatzgebiete werden bogenreiche, ueberwiegend nicht elektrifizierte Strecken sein, die das neue Fahrzeug mit 160 km/h befaehrt. Viele Erfahrungen aus Bau und Betrieb des VT 610 flossen in die Konzeption ein, so dass ein den Anforderungen von Fahrgast- und Umweltfreundlichkeit, Wartung und Wirtschaftlichkeit entsprechendes Fahrzeug bereitsteht. Die elektrische Neigetechnik ist eine gemeinsame Entwicklung der ABB Daimler-Benz Transportation (Deutschland) GmbH und der Daimler Benz Tochter EXTEL SYSTEMS WEDEL (ESW). Sie ist platzsparend unterflur angebracht und zeichnet sich durch geringes Gewicht

  19. Balti põgenike problemaatika USA poliitikas 1945-1952 / Kaja Kumer-Haukanõmm

    Index Scriptorium Estoniae

    Kumer-Haukanõmm, Kaja

    2007-01-01

    Teise maailmasõja järel lähtus enamik riike pagulaste kohta käivate otsuste langetamisel USA tegevusest. Sõjapõgenike küsimusega tegelenud organisatsioonidest. Perioodi jooksul toimunud muutustest põgenikelaagrites viibinute suhtes. Keeruline aeg Balti riikide pagulaste jaoks oli 1946. aasta ja 1947. aasta esimene pool. Tõenäoliselt ei abistanud USA balti põgenikke ainult humanistlikel kaalutlustel, vaid neid kasutati külma sõja algul Nõukogude Liiduga suheldes sageli manipuleerimisvahendina

  20. Dr. Arthur Puksovi Fondi teadaanne / Ivar Nippak

    Index Scriptorium Estoniae

    Nippak, Ivar

    2005-01-01

    1975. aastal asutatud fondi eesmärgiks on innustada Eesti vanema ajaloo teaduslikku uurimist ja vastavate tööde kirjastamist. 2004. aastal tunnistati I auhinna vääriliseks Tiiu Reimo monograafia "Raamatukultuur Tallinnas 18. saj. teisel poolel" (2001); II auhinna sai Aivar Põldvee monograafia "Pakri rootslaste kaebused Karl XI-le 1684. aastal: muutuste aeg Harju-Madise ja Risti kihelkonnas" (2001) ja pikema artikli "Talurahvakoolid Eesti- ja Liivimaal 17. sajandi viimasel veerandil" (2002) eest. 2005. aastal fond auhindu ei andnud. Auhinnavõistlus 2006. aastaks on välja kuulutatud

  1. 油脂基表面活性剂在矿物浮选中的应用%Oil based surfactants in the application of mineral flotation

    Institute of Scientific and Technical Information of China (English)

    任小荣; 牛金平; 韩亚明

    2009-01-01

    综述了以天然油脂为原料生产的几种表面活性剂,如脂肪酸及其衍生物、脂肪醇醚羧酸盐(AEG)、脂肪醇醚磷酸酯、脂肪胺及其衍生物在矿物浮选中的应用.认为矿物浮选是表面活性剂的重要应用领域之一,且该行业对表面活性剂的需求正在迅速增加.

  2. "Möödapääsmatust hädast sunnituna otsustanud ja nõustunud meid Poola Kuninglikule Majesteedile truualamlikuks teha" : Liivimaaseisuste alistumine Poola võimule 1561. aasta sügisel / Enn Tarvel

    Index Scriptorium Estoniae

    Tarvel, Enn, 1932-

    2011-01-01

    Poola-Leedu huvist ja tegevusest Liivimaa suhtes enne 1561. aastat, mil Rootsi aktiivne sekkumine Põhja-Eestis muutis otsustavamaks ka Poola-Leedu sekkumise Liivimaal. 1561. aasta sügisel pidas ordumeister Kettler poolakatega salaläbirääkimisi ja otsustas alistuda. 28. novembril 1561 andsid ordumeister, Riia peapiiskop, orduaadli ning Võnnu ja Volmari linna esindajad truudusvande Sigismund II Augustile. Tegelik Poola aeg algas Eestis 1582 ja kestis 1625. aastani. Dokument: Poola kuninga Sigismund Augusti ja ordumeister Gotthardi vahel sõlmitud alistumisleping. Vilniuses 28. novembril 1561("Pacta subjectionis")

  3. 1st February 2011-CERN Cultural Board for Engaging with the Arts, visiting CMS experimental area and LHC Tunnel at Point 5

    CERN Multimedia

    Michael Hoch

    2011-01-01

    Photo 1-4: Visit to CMS Control Room with G. Tonelli,CMS Collaboration Spokesperson Photo 5-9,16-20:CMS experimental area Photo 10-15:LHC Tunnel at Point 5 Photo 21:F. Madlener,Director of IRCAM Paris+S. Dorny,Director-General Lyon Opera House+C. Bollman,Art by Genève+M. Doser,AEgIS Collaboration Spokesperson,Former Physics Department Deputy Head+A. Koek,International Arts Development+G. Tonelli+M. Monje Cano,Arts Development Assistant (part-time work experience)+B. Ruf,Director of Kunsthalle Zürich

  4. "Ostanovimsja na mig v tishine..." : [luuletused] / Ene Mihkelson ; lühibiograafia: T. L. [Toomas Liiv

    Index Scriptorium Estoniae

    Mihkelson, Ene, 1944-

    1999-01-01

    Sisu: "Ostanovimsja na mig v tishine..." / tlk. V. Fadin ; Rekviem / tlk. Marju Lauristin ; "Dom eto tolko godõ..." ; "Dvoje bezumtsev mezh nimi treti..." ; "Eva v Tapa zhivjot / tlk. Boris Tuch ; "Ljagushka prõgnula skvoz lezvije kossõ..." ; "Vse stantsii peremeshtshalis..." ; "Dõb iz trub stekajet..." ; "Vremja neuklonno i surovo..." / tlk. M. Korol ; Pjat tshassov kogda snega net / tlk. Jelena Salkova. Orig.: Reekviem ; "Konn hüppas vikatist läbi..." ; "Kõik jaamad segunesid Valisime keeli..." ; "Suits sajab korstnaist maha..." ; "Aeg on karm ja ühepoolne Meid..."; Kell viis kui pole lund

  5. Development of high voltage dc transmission at Siemens Schuckertwerke up to 1945

    Energy Technology Data Exchange (ETDEWEB)

    Bosch, M.; Schiele, O.

    1966-09-01

    High voltage dc affords advantages over three phase ac in the transmission of power over long distances and over cables, and in the coupling of three phase systems. Mercury arc rectifiers and equipment for dc voltages from 100 to 200 kV were developed and put into service in the period between 1937 and 1945. A few years ago a high voltage dc transmission group was formed by AEG, BBC and Siemens to continue the work interrupted at the end of the war.

  6. Meie kobar PÖFFi peamises põõsas / Tarmo Teder

    Index Scriptorium Estoniae

    Teder, Tarmo, 1958-

    2007-01-01

    Pimedate Ööde Filmifestivalist, Eesti filmide võistlusprogrammist, mille auhinna rahastajaks on Scottish Leader Eesti. Konkurssprogrammis on 12 täispikka filmi: "Sügisball" (rezh. Veiko Õunpuu), "Nuga" (rezh. Marko Raat), "Dirigendi kõla" (rezh. Helle Karis, Peter Murdmaa), "Vastutuulesaal" (rezh. Priit Valkna), "Klass" (rezh. Ilmar Raag), "Kuhu põgenevad hinged" (rezh. Rainer Sarnet), "Tervitusi Nõukogude Eestist!" (rezh. Urmas Eero Liiv), "Jonathan Austraaliast" (rezh. Sulev Keedus), "Georg" (rezh. Peeter Simm), "Debora Vaarandi aeg" (rezh. Katrin Laur), "Jan Uuspõld läheb Tartusse" (rezh. Andres Maimik, Rain Tolk), "Põdra kuningriik" (rezh. Rein Maran)

  7. Ajaloo läbistav valgus / Andri Ksenofontov

    Index Scriptorium Estoniae

    Ksenofontov, Andri, 1962-

    2010-01-01

    Vano Allsalu näitus "Süütuse aeg" Tallinnas Hobusepea galeriis 22.09.-4.10. 2010. Franyó Aatothi (István Ferenc Tóth) näitus Ungari Instituudis 15. oktoobrini 2010. Monika Žaltauskaitė-Grašienė, Severija Inčirauskaitė-Kriaunevičienė ja Monika Järg'i näitus "Side minevikust / Connected with the past" Tallinnas galeriis Hop 10.-28. septembrini 2010

  8. 'Eesti Vabariik...' : [luuletused] : [luuletused] / Veiko Märka

    Index Scriptorium Estoniae

    Märka, Veiko, 1964-

    1997-01-01

    Sisu: 'Eesti Vabariik...'; 'SUUR MAALRITÖÖ...'; 'Rahvale...'; 'Tehniline progress...'; 'Saage ometi aru...'; 'Miks mitte...'; 'Rahvas...'; 'Ega see...'; 'Värvilised metallid...'; 'Tänapäeval võib...' ; Eestlase elu : 'Kui edu võtmed...'; 'AS Eesti Mets...'; 'Ajalugusid...'; 'Baltimaad...'; 'Kuigi karu...'; 'Meie peaeesmärk...'; 'Küllap Euroopa ühisköögis...'; 'Sahara looduslik seisund...'; 'Kus võileibu...'; 'Minevik...'; 'Ka ajaloo ilu...'; 'Aastad...'; 'Jumal...'; 'Eeva...'; 'Oli ikka ülekohus küll...'; 'Esimese Baltimaade rahvana...'; 'Valgustatud absolutismi...'; 'Kõik revolutsioonid on ühesugused...'; 'Kuidas küll aeg lendab...'; 'Ajalugu...'

  9. Short Outlines of Books by Estonian authors / Rutt Hinrikus

    Index Scriptorium Estoniae

    Hinrikus, Rutt, 1946-

    2007-01-01

    Tutvustus: Miljutina, Tamara. Inimesed minu elus. Tallinn : Varrak, 2007 ; Soosaar, Enn. Isa ja aeg. Tallinn : Kultuurileht, 2007. (Loomingu Raamatukogu ; 5) ; Paju, Imbi. Tõrjutud mälestused. Tallinn : Eesti Entsüklopeediakirjastus, 2007 ; Kaplinski, Jaan. Seesama jõgi. Tallinn : Vagabund, 2007 ; Laanem, Tiina. Väikesed vanamehed. Tallinn : Eesti Päevalehe Kirjastus, 2007 ; Vaarandi, Debora. Aastad ja päevad. Tallinn : Tänapäev, 2006 ; Berg, Maimu. Unustatud inimesed. Tallinn : Tuum, 2007 ; Heinsaar, Mehis. Rändaja õnn. Tallinn : Verb, 2007

  10. Naiskunstnike invasioon : juhus või paratamatus? / Reet Varblane

    Index Scriptorium Estoniae

    Varblane, Reet, 1952-

    2006-01-01

    Christel Alliku lillemaalid Draakoni galeriis kuni 4. III; Nelly Drelli maalinäitus "Taassünd" Viviann Napa galeriis kuni 15. III; Silva Eheri maalinäitus "Midagi ei toimu" G-galeriis kuni 4. III; Jarõna Ilo joonistused "(Aasta)aeg" Hausis kuni 3. III; Kristiina Kaasiku maalinäitus "Ad astra" Ühispanga galeriis kuni 3. III; Krista Möldri "Proloog maamärkidele" Deco galeriis kuni 4. III; Eveli Variku "Sünnimärgid" Tallinna raekoja fotokeldris "Lee" kuni 6. III; Kadri Alesmaa ja Jaak Visnapi "Disainitud kunst. Kõik müügiks" Tallinna Linnagaleriis kuni 5. III

  11. Värsse / Rudolf Rimmel

    Index Scriptorium Estoniae

    Rimmel, Rudolf, 1937-2003

    2008-01-01

    Sisu: "Elan Eestis ja selge on see..." ; "Eesti Vabariigi ajaloo lisana..." ; "ma ütlen lause Eesti vabaduse hinnast..." ; "Õiglust ja kõlblust üksainuski sõõm..." ; "Euroopa Liit on rahvuste kalmistu..." ; "meie jalge alt müüakse maad...." ; "teab setu ja soomegi hõim..." ; "poliitikas ei ole Eestis diletante..." ; "Pean salmi looma ma..." ; "Kord tuleb aeg, kui mõtte kaotab seadus..." ; "äriideid - olen päri..." ; "vanapapi kallis eestiaegses kukrus..." ; "sul häbelikkust olgu kasvõi raas..." ; "Hea lahe Eesti Vabariik on lukuta...". Rudolf Rimmeli seniavaldamata luulet saatis Kesknädalale Malle Rimmel

  12. Tähtede ja laulukooridega jõulutuuritama / Mari Hiiemäe

    Index Scriptorium Estoniae

    Hiiemäe, Mari

    2008-01-01

    Jõulukontsertidest: Annely Peebo ja Revalia Kammermeeskoori "Jõulureis läbi ajastute", Dave Bentoni ja segakoori Sõpruskond "Häid jõule!", Maarja-Liis Ilusa ja Tallinna Poistekoori "Püha öö", Rolf Roosalu ja Nele-Liis Vaiksoo "Imede öö", Anna-Liisa Suppi ja Sofia Rubina "Südamele südamest", Liisi Koiksoni ja Marko Matvere "Jõululood", Ivo Linna ja Suisapäisa "Kaunimad jõululaulud", "Jõulutuur" koos Tallinna Kammerorkestriga, Birgit Õigemeele ja Uku Suviste "Ilus aeg" ETV lastekooriga

  13. Tallinn ja Moskva austagu teineteist / Terry Davis

    Index Scriptorium Estoniae

    Davis, Terry

    2007-01-01

    Ilmunud ka: Molodjozh Estonii, 8. mai 2007, lk. 4; Postimees : na russkom jazõke, 9. mai 2007, lk. 9. Euroopa Nõukogu peasekretär mõistab hukka vandalismi ja rüüstamise Tallinna ja Moskva tänavatel Teise maailmasõja mälestusmärgi teisaldamise pärast ning ütleb, et on aeg käituda väärikalt nii teineteise kui mineviku suhtes, kuigi see võib olla vastuoluline

  14. GEANT4 simulation of the ACE beam line : Measurement of the energy distribution of degraded Antiproton beam and the ToF signal of generated pions.

    CERN Document Server

    BRAHIMI, Nihel

    2014-01-01

    The present document describes my 8 weeks work project as a summer student at the AEgIS experiment under the supervision of Michael Doser and what i have learned during this period . It can be devided into three main tasks which are: Theoretical preparations concerning low energy antiproton physics. Learning the basic principles of GEANT4 simu- lation toolkit. Using GEANT4 platform to follow up the work of two technical students (Logan and Conrad) in designing an experiment (ACE beam line ) which aims at improving the methods of detect- ing matter-antimatter annihilations vertices at low energies in terms of resolution and accuracy using hybrid detectors .

  15. Arhitektuuriaasta 2004 = The year in architecture 2004 / Epp Lankots

    Index Scriptorium Estoniae

    Lankots, Epp, 1976-

    2005-01-01

    Arhitektuuriauhindade nominentidest ja premeeritutest. Eesti Kultuurkapitali aastapreemia sai Toomas Rank Rägavere mõisa renoveerimise eest. Arhitektuuri sihtkapitali renoveerimispreemia - Mari Kurismaa, Eesti Draamateatri interjööride renoveerimine; objektipreemia - Martin Aunin, Ülemiste hotell; interjööripreemia - Jan Joonas Graps, Ken-Kristjan Ruut, "Jungenti" büroo; arhitektuurse tegevuse preemia - Kristjan Holm, Liina Jänes, Agu Külm, Jukka-Pekka Jalovaara, Pille Epner, Madis Jürgen, Tõnu Kaalep, Ingmar Muusikus, Eesti ekspositsioon "Aeg-maha-arhitektuur" Veneetsia arhitektuuribiennaalil

  16. 17. X avati XIV rahvusvaheline Tallinna graafikatriennaal, seekord ülddeviisi "Poliitiline/Poeetiline" all / Eve Kask

    Index Scriptorium Estoniae

    Kask, Eve

    2007-01-01

    Tallinna XIV graafikatriennaalist (Anders Kreugeri koostatud näitus "1987. Baltimaade graafika ja plakatid nõukogude aja viimasest kümnendist" ja põhinäitus "Poliitiline/Poeetiline" Kumu Kunstimuuseumis, Anders Härmi kuraatorinäitus "Poliitiline/Poeetiline" Tallinna Kunstihoones ja selle galeriis, Egle Kuckaite isikunäitus Tallinna Linnagaleriis, triennaali paneel Kadrioru Kunstimuuseumis). Triennaali peaauhinna sai Oscar Munos. Triennaaliga samaaegselt Tallinnas toimuvast rahvusvahelisest graafikakonverentsist "Impact 5" teemal "Lõigatud aeg", mille raames on avatud graafikanäitused

  17. Kas tegeleda uue töölepinguseadusega või mitte? / Väino Linde

    Index Scriptorium Estoniae

    Linde, Väino, 1959-

    2008-01-01

    Töölepingu seaduse eelnõust, kehtiva töölepingu puudustest ning kompromissi vajalikkusest. Ilmunud ka Sakala 23. jaan. 2008, lk. 2, pealkiri kujul: aeg otsida kompromisse ; Vali Uudised 23. jaan. 2008, lk. 2 ; Põhjarannik 22. jaan. 2008, lk. 4 ; Meie Maa 23. jaan. 2008, lk. 2 ; Hiiu Leht 25. jaan. 2008, lk. 2 ; Vooremaa 24. jaan. 2008, lk. 2 ; Võrumaa Teataja 24. jaan. 2008, lk. 2 ; Pärnu Postimees 25. jaan. 2008, lk. 15 ; Lääne Elu 26. jaan. 2008, lk. 2, Virumaa Teataja 29. jaan. 2008, lk. 11

  18. Theoretical and Experimental Investigation of Heterojunction Interfaces

    Science.gov (United States)

    1983-11-01

    Ge grown on substrates of (111), (110), and (100) GaAs have been Investigated with x-ray photoelectron spectos - copy. Observed changes in core-level...determinations were made on each interface. In all cases, measure- ment reproducibility was ɘ.01 eV and was usual- ly ɘ.005 eV; calibration uncertainties...0.01 eV and in most cases it was < ±0.005 eV. Calibration uncertainties increase the total error limits for AEg to ±0.01 eV In the table, we also list

  19. American Society for Clinical Pharmacology and Therapeutics (ASCPT)-111th annual meeting. 17-20 March 2010, Atlanta, GA, USA.

    Science.gov (United States)

    Veryard, Claire

    2010-05-01

    The 111th Annual Meeting of the American Society for Clinical Pharmacology and Therapeutics, held in Atlanta, included topics covering disclosures of new data in the field of pharmacokinetics and drug interactions. This conference report highlights selected presentations on pharmacokinetic studies of several investigational drugs, including evatanepag (Pfizer Inc), AEG-33773 (Aegera Therapeutics Inc), JNJ-16269110 (Johnson & Johnson Pharmaceutical Research & Development LLC), PF-3716539 (ViiV Healthcare), MK-0736 (Merck & Co Inc), a combination of Ginkgo biloba and cilostazol (Renexin SK Chemicals Co Ltd), PP-101 (Pacific Pharmaceuticals Co Ltd), ACT-178882 (Acetlion Ltd/Merck & Co Inc) and edoxaban (Daiichi Sankyo Co Ltd).

  20. Kinoelamus muutub kolmemõõtmeliseks / Jaanus Noormets

    Index Scriptorium Estoniae

    Noormets, Jaanus

    2008-01-01

    Sellest nädalast näidatakse Tallinnas Coca Cola Plazas tänu uuele erilisele tehnoloogiale ka kolmemõõtmelisi filme (3D-filme): detsembris 2008 - "Reis maakera südamesse" ("Journey to the Centre of the Earth"); jaanuaris 2009 - "Välk" ("Bolt"), märts 2009: "My Bloody Valentine"; aprillis 2009 - "Koletised tulnukate vastu" ("Monsters vs. Aliens") ; kevadel 2009 - "Coraline" ; juulis 2009 - "Jääaeg 3". Sellest reedest alates näidatakse kobarkinos 3D-animafilmi "Kärbsed Kuu peale" ja muusikafilmi "U2 3D"

  1. Nõukogude postmodernism = Soviet postmodernism / Ants Juske

    Index Scriptorium Estoniae

    Juske, Ants, 1956-

    2010-01-01

    Analüüsitakse, kuidas ja milliseid teid pidi igasugused "-ismid" jõudsid läbi raudse eesriide Ida-Euroopa maadesse. Esimestena haakusid postmodernismiga avangardistlikud arhitektid, seejärel toimusid nihked ka kujutavas kunstis, kunstiteaduses ja -kriitikas. Nõukogude aeg jättis jälje meie kunstile, kuid see "nõukogude" on rohkem iroonilises võtmes mõistetud, sisaldades alltekste - kas tegemist on šedöövriga või kunstnik lihtsalt lollitab - ja "nõukogude postmodernism" on seetõttu läänele raskesti mõistetav

  2. Tuning a Schottky barrier of epitaxial graphene/4H-SiC (0001) by hydrogen intercalation

    Energy Technology Data Exchange (ETDEWEB)

    Dharmaraj, P.; Justin Jesuraj, P.; Jeganathan, K., E-mail: kjeganathan@yahoo.com [Centre for Nanoscience and Nanotechnology, School of Physics, Bharathidasan University, Tiruchirappalli 620 024, Tamil Nadu (India)

    2016-02-01

    We report the electron transport properties of epitaxial graphene (EG) grown on 4H-SiC (0001) by low energy electron-beam irradiation. As-grown EG (AEG) on SiC interface exhibits rectifying current-voltage characteristics with a low Schottky barrier (SB) of 0.55 ± 0.05 eV and high reverse current leakage. The SB of AEG/SiC junction is extremely impeded by the Fermi level pinning (FLP) above the Dirac point due to charged states at the interface. Nevertheless, a gentle hydrogen intercalation at 900 °C enables the alleviation of both FLP and carrier scattering owing to the saturation of dangling bonds as evidenced by the enhancement of SB (0.75 ± 0.05 eV) and high electron mobility well excess of 6000 cm{sup 2} V{sup −1} s{sup −1}.

  3. Mass Wasting Following the 2002 Missionary Ridge Fire near Durango, Colorado, a Field Trip Guidebook

    Science.gov (United States)

    Bigio, Erica R.; Blair, Robert W.; Burke, Michael; Cannon, Susan H.; deWolfe, Victor G.; Ey, John; Gartner, Joseph E.; Gillam, Mary L.; Knowlton, N.D.; Santi, Paul M.; Schulz, William H.; Coe, Jeffrey A.

    2007-01-01

    This field trip guide focuses on mass wasting following the 2002 Missionary Ridge fire near Durango, Colorado. We prepared this guide to accompany a May 4, 2006, field trip during the second Roy J. Shlemon Specialty Conference, which was held in Durango, Colorado, May 3-5. The conference, entitled Mass Wasting in Disturbed Watersheds, was sponsored by the Association of Environmental & Engineering Geologists (AEG) and the AEG Foundation. The objective of this Shlemon Conference was to bring together practitioners and researchers to define the current state of practice and identify unresolved problems with regard to the prediction and mitigation of mass wasting in disturbed watersheds. The one-day field trip begins and ends in Durango. Many of the field trip stops are at debris-flow fans around the periphery of the burn area, but one stop examines landslide activity in the burn area that initiated during spring 2005 snowmelt within a dormant, deep-seated landslide, as well as an erosion/debris-flow mitigation effort in a drainage basin above Lemon Reservoir. Also provided are descriptions of the Missionary Ridge fire, the geologic and climatic setting of the field-trip area, and the general effects of wildfire on watersheds.

  4. New Typical Vector of Neurotoxin β-N-Methylamino-l-Alanine (BMAA in the Marine Benthic Ecosystem

    Directory of Open Access Journals (Sweden)

    Aifeng Li

    2016-11-01

    Full Text Available The neurotoxin β-N-methylamino-l-alanine (BMAA has been identified as an environmental factor triggering neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS and Alzheimer’s disease (AD. We investigated the possible vectors of BMAA and its isomers 2,4-diaminobutyric acid (DAB and N-2(aminoethylglycine (AEG in marine mollusks collected from the Chinese coast. Sixty-eight samples of marine mollusks were collected along the Chinese coast in 2016, and were analyzed by an HILIC-MS/MS (hydrophilic interaction liquid chromatography with tandem quadrupole mass spectrometer method without derivatization. BMAA was detected in a total of five samples from three species: Neverita didyma, Solen strictus, and Mytilus coruscus. The top three concentrations of free-form BMAA (0.99~3.97 μg·g−1 wet weight were detected in N. didyma. DAB was universally detected in most of the mollusk samples (53/68 with no species-specific or regional differences (0.051~2.65 μg·g−1 wet weight. No AEG was detected in any mollusk samples tested here. The results indicate that the gastropod N. didyma might be an important vector of the neurotoxin BMAA in the Chinese marine ecosystem. The neurotoxin DAB was universally present in marine bivalve and gastropod mollusks. Since N. didyma is consumed by humans, we suggest that the origin and risk of BMAA and DAB toxins in the marine ecosystem should be further investigated in the future.

  5. Metadherin/astrocyte elevated gene-1-based DNA vaccine suppresses progression and metastasis in prostate cancer of mice%异黏蛋白/星形细胞上调基因-1靶点的基因疫苗诱导免疫抑制小鼠前列腺癌生长及转移

    Institute of Scientific and Technical Information of China (English)

    张春; 李惠长; 钱本江; 刘昌明; 李国敏; 薛清平

    2013-01-01

    Objective To study the metadherin (MTDH)/astrocyte elevated gene-1 (AEG-1) as targets for gene vaccine inducing immunosuppression mice prostate cancer growth and metastasis of action research.Methods Male C57BL/6 mice (6-8 weekes old) were randomly divided into three groups (n =20),respectively,to phosphate buffered saline (PBS),Pub,Pub-MTDH/AEG-1 attenuated salmonella (1 × 10s cfu) of lavage servo immune; Immune once a week,a total of immune three times.Last one week after the immunization,all in three groups of mice prostate in situ (right and left dorsal lobe) vaccinated 10s RM-1 cell to build orthotopic transplantation tumor model of prostate,induced spontaneous pelvic cavity and retroperitoneal lymph node metastasis; Record each group mice with tumor size,pelvic cavity and retroperitoneal lymph node metastasis number [hematoxylin and eosin (HE) staining shall prevail],CD8 in through immunohistochemical method to detect in situ tumor,the expression of vascular endothelial growth factor (VEGF) and lymphatic vessel endothelial hyaluronic acid receptor-1 (LYVE-1) case,tumor cell apoptosis with TdT-mediated dUTP nick end labeling (TUNEL) method.Results pUb-MTDH/AEG-1 DNA vaccine group compared to the pUb,the PBS group could significantly stimulate CD8 + T cells and cytotoxic T lymphocyte (CTL) response; Effectively inhibit the growth of prostate cancer in situ in mice,MTDH group tumor volume (0.248 ± 0.102) compared with the Pub group (1.475 ± 0.314) (P < 0.01),pelvic cavity and retroperitoneal lymph node metastasis 77.78%,35.7% (P < 0.05) ; Significantly enhanced the expression of CD8 + in the in situ tumor molecular:MTDH group (3.56 ± 0.85),Pub group (5.12 ± 0.90) (P < 0.05),and promote tumor cell apoptosis:MTDH group (39.60 ± 3.28) %,Pub group (16.18 ±2.52)% (P<0.01).Conclusion MTDH/targets AEG-1 gene vaccine in mice prevention immune models,can effectively induce the body specificity immune response,enhance cellular immunity and humoral

  6. The hundredth Gentner Doctoral Student has started at CERN

    CERN Multimedia

    CERN Bulletin

    2016-01-01

    Almost ten years after the start of the programme in 2007, the hundredth Gentner Doctoral Student started his PhD at CERN.   The hundredth Gentner Doctoral Student, Christian Zimmer, in front of the AEgIS detector in the AD hall, where he will spend a significant portion of the next 3 years. In 2007, the German Gentner Doctoral Student Programme was established at CERN, named in honour of the celebrated nuclear physicist Wolfgang Gentner, President of the CERN Council from 1972-74. On 1 July 2016, the 100th Gentner Doctoral Student, Christian Zimmer, started his PhD at CERN, where he will work on setting up the sympathetic laser cooling of antiprotons at the AEgIS experiment. CERN’s Doctoral Student Programme has been running for many years, with 200 students currently enrolled. The Gentner programme is fully integrated into the general CERN Doctoral Student Programme, but is entirely funded by the German Federal Ministry of Education and Research (BMBF). The programme sponsors 30 to 40...

  7. Cor a 14 is the superior serological marker for hazelnut allergy in children, independent of concomitant peanut allergy

    DEFF Research Database (Denmark)

    Eller, Esben; Mortz, Charlotte G; Bindslev-Jensen, Carsten

    2016-01-01

    BACKGROUND: Hazelnut is the most frequent cause of tree-nut allergy, but up to half of all children with hazelnut allergy additionally suffers from peanut allergy. Our aim was to identify diagnostic values of the most promising serological markers (Cor a 9 and Cor a 14) and to address the influence...... of concomitant peanut allergy and PR10 sensitization. METHOD: We included 155 children suspected off hazelnut allergy and challenged according to guidelines. Concomitant allergy to peanuts was verified or ruled out by challenge. Skin Prick Test, s-IgE and CRD to hazelnut, peanut, PR10 and LPT protein families...... were measured using ImmunoCap. RESULTS: Sixty-five children had a positive hazelnut challenge, and 60% of these also had concomitant peanut allergy. Children allergic to hazelnut were sensitized to Cor a 9 and Cor a 14; peanut allergic children to Ara h 2. Sensitization to PR10 protein components were...

  8. Central adiposity in children born small and large for gestational age Adiposidad central en niños que nacieron con poco o con excesivo peso para su edad gestacional

    Directory of Open Access Journals (Sweden)

    M. Biosca

    2011-10-01

    Full Text Available Objective: To evaluate body composition differences between children that were born small (SGA or large for gestational age (LGA compared with their counterparts born adequate for gestational age (AGA. Methods: Body composition was assessed in 124 healthy Caucasian children (50% girls aged 6-10, classified according to their birth weight for gestational age as AGA, SGA and LGA. Fat mass (FM, percentage of FM, lean mass (LM, bone mineral content (BMC and bone mineral density were measured by dual-energy X-ray absorptiometry (DXA in the whole body and at different body regions. Results: LM (adjusted for age and sex and total BMC (adjusted for age, sex and weight were both significantly higher in LGA children and lower in SGA when compared with those born AGA. After adjustments for height, LM and BMC differences between groups were not significant. In SGA children, truncal (P Objetivo: Evaluar las diferencias que existen en la composición corporal de aquellos niños que nacieron pequeños (PEG o grandes para su edad gestacional (GEG en comparación con los que presentaban un peso adecuado al nacer (AEG. Métodos: La composición corporal se valoró en 124 niños caucásicos (50% niñas con edades entre 6 y 10 años, clasificados según su peso al nacer como AEG, PEG y GEG. La masa grasa (MG, el porcentaje de MG, la masa magra (MM, el contenido mineral óseo (CMO y la densidad mineral ósea se midieron mediante absorciometría dual de rayos X (DXA tanto globalmente como en las diferentes regiones corporales. Resultados: La MM (ajustada por edad y sexo y el CMO (ajustado por edad, sexo y peso fueron mayores en los GEG y menores en los PEG al compararlos con los AEG; al ajustar la MM el CMO por la altura, dichas diferencias ya no fueron significativas. En los PEG, la grasa abdominal (p < 0,01 y en el tronco (p < 0,05 eran mayores que en los AEG y que en los GEG tras ajustar por edad, sexo y altura. No existían diferencias en el porcentaje de MG

  9. 78 FR 69883 - Investigations Regarding Eligibility To Apply for Worker Adjustment Assistance

    Science.gov (United States)

    2013-11-21

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF LABOR... to determine whether the workers are eligible to apply for adjustment assistance under Title II...). 83163 Osram Sylvania (State/One- Luquillo, PR 10/22/13 10/21/13 Stop). 83164 Philips Lumileds...

  10. EST Table: CK528352 [KAIKOcDNA[Archive

    Lifescience Database Archive (English)

    Full Text Available CK528352 rswfa0_006832.y1 10/09/29 100 %/165 aa dbj|BAD90848.1| cyclophilin-like pr... 10/08/28 66 %/168 aa Y49A3A.5#CE22213#WBGene00000877#locus:cyn-1#Peptidyl-prolyl cis-trans isomerase#status:Confirmed#UniProt:P52

  11. 75 FR 27774 - Eagle Rock Desoto Pipeline, L.P.; Notice of Rate Election

    Science.gov (United States)

    2010-05-18

    ... [Federal Register Volume 75, Number 95 (Tuesday, May 18, 2010)] [Notices] [Page 27774] [FR Doc No: 2010-11793] DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. PR10-22-000] Eagle..., Eagle Rock Desoto Pipeline, L.P., (Desoto) filed a Notice of Rate Election pursuant to section...

  12. 乙氧基化对表面活性剂最终生物降解性能的影响%Effect of ethoxylation on ultimate biodegradability of surfactants

    Institute of Scientific and Technical Information of China (English)

    张广良; 冯瑜; 李国晋; 宋鹏

    2014-01-01

    采用CO2气体溢出法研究了乙氧基化对非离子及阳离子表面活性剂最终生物降解性能的影响。结果表明,对于非离子表面活性剂APG与对应的AEG,经过乙氧基化后的AEG最终生物降解率较APG略有升高;对于阳离子表面活性剂二硬脂酸乙酯基甲基硫酸甲酯铵(2C17EQDMS)与对应的乙氧基化二硬脂酸乙酯基羟乙基甲基硫酸甲酯铵(2C17EQDMS-3EO),2C17EQDMS-3EO的最终生物降解率较2C17EQDMS也略有升高;对于三硬脂酸乙酯基甲基硫酸甲酯铵(3C17EQDMS)及对应的乙氧基化三硬脂酸乙酯基甲基硫酸甲酯铵(3C17EQDMS-nEO),3C17EQDMS-nEO的最终生物降解率较3C17EQDMS下降,并且随着EO链的增加,最终生物降解率呈下降趋势。%The effect of ethoxylation on ultimate biodegradability of surfactants was studied by CO2 evolu⁃tion method. The results showed that for nonionic surfactants alkyl polyglycosides (APG) and the correspond⁃ing AEG, after ethoxylation the ultimate biodegradability of AEG was increased slightly compared with APG;for anionic surfactants di-stearic acid methyl ammonium methylsulfate (2C17EQDMS) and the corresponding ethoxylated di-stearic acid hydroxyethyl methyl ammonium methylsulfate (2C17EQDMS-3EO), after ethoxyl⁃ation the ultimate biodegradability of 2C17EQDMS-3EO was also increased compared with 2C17EQDMS; but for tri-stearic acid methyl ammonium methylsulfate (3C17EQDMS) and the corresponding ethoxylated tri-stea⁃ric acid methyl ammonium methylsulfate 3C17EQDMS-nEO, after ethoxylation the ultimate biodegradability of 3C17EQDMS-nEO was decreased, and with the increase of EO chains, the biodegradability was on the decline.

  13. 食管胃结合部腺癌流行趋势、病因及防治%Adenocarcinoma of the esophagogastric junction:epidemic trends, causes, prevention and therapy

    Institute of Scientific and Technical Information of China (English)

    陈志峰

    2012-01-01

    Population epidemiology analysis of esophageal cancer for the high risk region in China finds that: incidence of esophageal squamous cell carcinoma has decreased and that of adenocarcinoma of the esophagogastric junction(AEG) has increased significantly. European and American scholars believe that obesity and stomach-esophageal reflux disease are independent risk factors of the two types of cancer. In the high risk region of esophageal cancer in China, the heritability is (29.67±4.32)% and the segregation ratio is 0.181, 95% CI (0.15-0.21). Esophageal cancer belongs to multi-gene genetic disease. According to the evolution of the pathological mechanism of gastric cardia adenocarcinoma and the WHO's clinical treatment principles, cardiac severe atypicalhyperplasia were mainly endoscopic resection in the high riskregion in China. Paying attention to the intervention ofatrophic gastritis or active gastritis may be the realisticmeasures to reduce intestinal metaplasia and the incidence ofAEG.%国内食管癌高发区人群流行病学分析发现:食管鳞癌发病率下降;食管胃结合部腺癌(AEG)发病率显著上升.欧美学者认为,肥胖和胃食管反流性疾病是这两类肿瘤的独立危险因素.我国食管癌高发区的遗传度为(29.67±4.32)%,分离比0.181,95%CI:0.15~0.21,属于多基因遗传病.根据AEG的病理演变机理和WHO的临床处理原则,目前食管癌高发区对贲门重度不典型增生者主要采用内镜下切除;而重视萎缩性或活动性胃炎的干预治疗,对降低肠化,减少AEG的发病也可能是比较现实的措施之一.

  14. Proximal gastrectomy and total gastrectomy controled clinical studies gastroesophageal junction cancer treatment%近端胃切除术和全胃切除术治疗食管胃结合部癌的临床对照研究

    Institute of Scientific and Technical Information of China (English)

    王治伟

    2014-01-01

    Objective: comparative analysis of total gastrectomy and proximal gastrectomy impact on the quality of life of cancer (AEG) in patients with esophageal gastric junction. Methods: AEG patients in our hospital in January 2012 -2013 December 30 routine total gastrectomy as a control group, and the other to select the same period in 30 patients with proximal gastrectomy routine as the observation group. Application-specific rating scale gastric (QLQ-STO22) evaluate the quality of life of patients. Results: The control group scored significantly higher than diet limited extent, the experimental group, the experimental group reflux, altered taste score was significantly higher (P <0.05). Conclusion: The proximal gastrectomy and total gastrectomy treatment AEG, wil merge different degrees of postoperative complications, the implementation of a lower total gastrectomy who taste and regurgitation scores, implementing proximal gastrectomy were restricted diet lighter degree.%目的:对比分析全胃切除术及近端胃切除术对食管胃结合部腺癌(AEG)患者生活质量的影响。方法选取我院2012年1月-2013年12月30例行全胃切除术的A E G患者作为对照组,另选取同期30例行近端胃切除术的患者作为观察组。应用胃癌特异性评价量表(QLQ-STO22)评价患者术后生活质量。结果对照组饮食受限程度得分明显高于实验组,实验组反流、味觉改变得分明显高于对照组(P<0.05)。结论采用近端胃切除术及全胃切除术治疗A E G,术后均会合并不同程度并发症,实施全胃切除术者味觉及反流得分更低,实施近端胃切除术者饮食受限程度更轻。

  15. "Ma vannun tema niuete kui paleuse nimel ..." : [luuletused] / tlk. Andres Ehin, tlk. Ly Seppel

    Index Scriptorium Estoniae

    2004-01-01

    Sisu: "Ma vannun tema niuete kui paleuse nimel ..." ; "Ta on nagu kuu, kelle kuma kõik kummuli kukutab ..." ; "Kuu südaöösel ennustab me jäävat lahkujääma ..." ; "Ei hinda naisterahvas kasinuse mulli ..." ; "Ta nõtket kaela kutsun ligemale ..." ; "Meid ühte heitma tõmbab armuköis ..." ; "Meil kahel pole mõtet lahku minna ..." ; "Ei kuuga saa võrrelda sind, sest et kuu läheb looja ..." ; "Allah ise su ilude hoob on ja kang ..." ; "Kui meesterahvale läeb korda meesterahvas ..." ; "Ja kuis ka kiremöll tal südames ei hulla ..." ; "Teie jaoks ei ole minu võlurohke kallike ..." ; "Oli see vast poisike, nägu ilu täis ..." ; "Aeg tagasi kalli las toob, et mind suisa salvata ...". Tundmatute autorite kirjutatud luuletused jutukogust "1001 ööd" (9. - 10. saj)

  16. Secondary emission monitor for keV ion and antiproton beams

    CERN Document Server

    Sosa, Alejandro; Bravin, Enrico; Harasimowciz, Janusz; Welsch, C P

    2013-01-01

    Beam profile monitoring of low intensity keV ion and antiproton beams remains a challenging task. A Sec- ondary electron Emission Monitor (SEM) has been de- signed to measure profiles of beams with intensities below 107 and energies as low as 20 keV. The monitor is based on a two stage microchannel plate (MCP) and a phosphor screen facing a CCD camera. Its modular design allows two different operational setups. In this contribution we present the design of a prototype and discuss results from measurements with antiprotons at the AEgIS experiment at CERN. This is then used for a characterization of the monitor with regard to its possible future use at different facilities.

  17. President kutsub koostööle / Arnold Rüütel

    Index Scriptorium Estoniae

    Rüütel, Arnold, 1928-

    2002-01-01

    Ilmunud ka: Postimees (2002) 25. veebr., lk. 11, pealk.: Vajame uut ühiskondlikku lepet; SL Õhtuleht (2002) 25. veebr., lk. 10, pealk.: Aeg rahvuslikuks leppeks, vt. samas karikatuur; Virumaa Teataja (2002) 26. veebr., lk. 7, pealk.: Eestis tuleb taastada sotsiaalne tasakaal; Maaleht (2002) 28. veebr., lk. 8, pealk.: Uhkus ajab upakile; Põhjarannik (2002) 26. veebr., lk. 5, pealk.: President Arnold Rüütli kõne Eesti Vabariigi 84. aastapäeval; Severnoje Poberezhje (2002) 26. veebr., lk. 5; Meie Maa (2002) 26. veebr., lk. 2, pealk.: Vajame põlvkondlikku järjepidevust ja uut ühiskondlikku lepet. President Arnold Rüütli kõne Eesti Vabariigi 84. aastapäeval Estonia teatris 24. veebruaril 2002. Lühendatult

  18. Short outlines of books by Estonian authors / Janika Kronberg, Rutt Hinrikus

    Index Scriptorium Estoniae

    Kronberg, Janika, 1963-

    2004-01-01

    Tutvustus: Talvik, Heiti. Legendaarne. Tartu : Ilmamaa, 2004 ; Pilter, Lauri. Lohejas pilv : romaan lühijuttudes. Tallinn : Tuum, 2004 ; Raud, Rein. Hector ja Bernard. Tallinn : Tuum, 2004 ; Ruben, Aarne. Elajas trepi eelastmel. Tallinn : Tuum, 2004 ; fs. 2004. Tallinn : Tuum, 2004 ; Normet, Dagmar. ...ainult võti taskus. Tallinn : Varrak, 2004 ; Künnap, Asko. Ja sisalikud vastasid (kolmes kirjas). Tallinn : Näo Kirik, 2003 ; Kall, Toomas. Armas aeg. Tallinn : Tänapäev, 2004 ; Õunapuu, Ervin. Eesti gootika II. Tallinn : Umara, 2004 ; Soomets, Triin. Leping number 2 : luuletusi 2000-2003. Tallinn : Tuum, 2004 ; Tuulik, Jüri. Linnusita : [jutustused, lühijutud, näidendid ja vested]. Tallinn : Maalehe Raamat, 2004 ; Raudam, Toomas. Teie. Tallinn : Eesti Keele Sihtasutus, 2003 ; Härm, Viiu. Keegi teeline : luuletused. Tallinn : Varrak, 2004 ; Härm, Viiu. Õhuaken : romaan. Tallinn : Varrak, 2004

  19. 肝癌中星形细胞上调基因1作用于microRNA-885-5p/基质金属蛋白酶9信号通路促进肝癌转移的机制研究%Mechanisms of astrocyte elevated gene-1 promoting cancer metastasis through regulation of the microRNA-885-5p/matrix metalloproteinase 9 signaling pathway in liver cancer

    Institute of Scientific and Technical Information of China (English)

    李聪; 邢秀亚; 张巍; 李京华; 王璇; 张洪海; 杨耿侠; 生守鹏; 孙玉

    2016-01-01

    Objective To investigate the relationship between astrocyte elevated gene-l (AEG-1) and microRNA-885-5p,observe the influence of microRNA-885-5p on MHCC-97H migration and invasion,identify the target gene of microRNA-885-5p and uncover the mechanisms of AEG-1 promoting cancer metastasis.Methods The experimental study was adopted.The AEG-1 over-expressed plasmid constructed and the siRNA of silent AEG-1 synthesized were transiently transfected into MHCC-97H cells,respectively.For plasmid transfection,MHCC-97H cells tranfected with empty Vector NC were divided into group A as the control,and MHCC-97H cells tranfected with AEG-1 over-expressed plasmid were divided into group B.For AEG-1 siRNA transfection,MHCC-97H cells tranfected with negative siRNA were divided into group C as the control,and MHCC-97H cells tranfected with AEG-1 siRNA were divided into group D.The relative expressions of microRNA885-5p in MHCC-97H cells of group A,B,C,D were measured by fluorescent quantitative polymerase chain reaction(PCR).For microRNA-885-5p simulator transfection,MHCC-97H cells tranfected with negative microRNA simulator were divided into group E as the control,and tranfected with microRNA-885-5p simulator were divided into group F.Transwell assay was used to evaluate MHCC-97H migration and invasion.Targetscan software was used to predict the target gene of microRNA-885-5p.MHCC-97H cells co-transfected with reporter plasmid of target gene and negative control siRNA were divided into group G as the control,and MHCC-97H cells co-transfected with reporter plasmid of target gene and microRNA-885-5p simulator were divided into group H.MHCC-97H cells co-transfected with reporter plasmid of target gene of binding region mutation and negative control siRNA were divided into group Ⅰ as the control,MHCC-97H cells co-transfected with reporter plasmid of target gene of binding region mutation and microRNA-885-5p simulator were divided into group J.The luciferase activities of MHCC-97H

  20. "Kes kaunis on, peab andma vastse võsu..." : [sonetid] / William Shakespeare ; tlk. Harald Rajamets, Ants Oras

    Index Scriptorium Estoniae

    Shakespeare, William, 1564-1616

    2006-01-01

    Sisu: "Kes kaunis on, peab andma vastse võsu..." ; "Sa peeglist näed: need palgejooned nüüd..." ; "Seesama aeg, mis kunstipeenelt voolib..." ; "Miks muusika teeb nukraks sind, kes ise..." ; "Ei, armastust ei tunne sinu rind..." ; "Nii ruttu, kui sa hääbud, uueks sirgud..." ; "Kui kuulen, kuidas aega mõõdab kell..." ; "Kuid miks sa ise tõhusamal moel..." ; "Kas suvepäeva sarnaseks sind kiita?..." ; "Aeg, õgard, küüned lõvil tömbiks kääna... ; "Ei veena peegel mind, et olen vana..." ; "Just nagu näitleja, kel kinni keel..." ; "Mu silm kui taidur võttis pilti teha..." ; "Mu armu isand, kelle truu vasall..." ; "Ma reisist väsinuna heidan sängi..." ; "Kui õnnest hüljatuna nutan sala..." ; "Kui vaikse leebe mõtte kohtu ette..." ; "Ma olen näinud küll, kuis tõusev päike..." ; "Ma tunnistan, et meid on siiski kaks..." ; "Nii nagu isa, vanadusest nõrka..." ; "Kui sulen laud, mu silmad hästi näevad..." ; "Nii ränk on reisida mul tüütul teel..." ; "Mis on su olemus, mis tuum su, miks..." ; "Ei kuningate uhked marmorsambad..." ; "Arm, uuenda end, nii et öelda sust..." ; "Kui uut ei olegi, vaid kõik on sama..." ; "Nii nagu lained ulgumerelt randa..." ; "Neiks päeviks, kui kord aeg mu armsal palge..." ; "Et näen, kuis aja käsi kõike lõhub..." ; "Kui pronksi, kivi, maad ja merd võib neelda..." ; "Mu tusk on ränk, nüüd surma kutsuks küll..." ; "Kui suren, ära leina mind sa kaua..." ; "Sa minus seda aastaaega näed..." ; "Mul sinust kirjutades arg on meel..." ; "Oo hüvasti! Liig kallis mul su hind..." ; "Siis vihka mind, kui pead, ja kohe praegu..." ; "Mõnd uhkeks teeb ta kunst, mõnd sünnipära..." ; "Sust eemal olin kevadel, mu arm..." ; "Kui möödaläinud aja kroonikais..." ; "Mis on veel ajul paberile kanda..." ; "Jah, tõsi, olen käinus siin ja seal..." ; "Ma uskuda ei saa, et murda suudab..." ; "On parem olla halb kui halvaks peetud..." ; "Ei, aeg, sa ära hoople, et mind muudad..." ; "Mu muusika, kui muusikat sa teed

  1. Steps towards the design of a cryogenic manipulator for an ultra-thin membrane in a 1T magnetic field

    CERN Document Server

    Vasev, Andrej

    2015-01-01

    The main purpose of my CERN's project is design, analysis and research on all conditions under which one cryogenic mechanism would produce extremely low temperatures needed for cooling down a silicon target in a closed magnetic system. Main source of the research is the AEgIS (Antihydrogen Experiment: Gravity, Interferometry, Spectroscopy) experiment of CERN, which aims to carry out the first direct measurement of a gravitational effect on an antimatter system. To reach this goal, a silicon target is bombarded by positrons in order to create positronium which is used to form antihydrogen atoms on which the experiment is going to be done. That would not be possible without the presence of a respective cooling system that secures constant extremely low temperatures in the silicon area. In the further development of the cryogenic system’s functionality, a special attention is given to its construction, used materials and interaction between each other.

  2. Ladina õigusterminite vormilisest ja sisulisest korrektsusest

    Directory of Open Access Journals (Sweden)

    Merike Ristikivi

    2008-05-01

    Full Text Available Õigusteadus on oma olemuselt tekstiteadus, milles väga suur tähtsus on keelelistel väljendusvahenditel. Juriidilise jõu saavad sõnad ja väljendid siin vahetult keele kaudu. Käesoleva artikli uurimismaterjal pärineb Eesti ainsa õigusteadusliku ajakirja Juridica 1993–2007 aastakäigu artiklitest. Uurimuses käsitletav periood on olnud Eesti õigusele murranguline aeg: tagasi on pöördutud läänelikku õigusruumi, mis lähtub ladinakeelsest baasist. Õigusreformiga on kaasnenud ka muudatused Eesti juristide terminikasutuses, lülitumine Euroopa õiguskultuuri on märgatavalt suurendanud ladina terminite kasutamist. Samas kaasnevad võõrkeelendite tarvitamisega mitmed praktilised probleemid. Artikkel keskendub ladina õigusterminite ortograafiale ja selle eripärale ning morfoloogiale ja selle suhtele eestikeelse lausega.

  3. 27 Estonian Music Festivals 2002

    Index Scriptorium Estoniae

    2003-01-01

    2002. aastal Eestis toimunud muusikafestivalidest: opeNBaroque 2002 (muusikafestival),Akadeemilised Trompetipäevad, Klavessiinimuusika Päevad, Eesti muusika päevad 2002,Mravinski Festival, Rudolf Tobiase muusikafestival, Eduard Tubin ja tema aeg (muusikafestival), Suure-Jaani muusikapäevad 2002,Regiöö (muusikafestival), David Oistrahhi festival, Haapsalu vanamuusikafestival 2002, Viljandi vanamuusikafestival 2002, Hiiumaa kammermuusikapäevad 2002, Klaaspärlimäng (festival),Mustjala Festival, Haapsalu viiulimuusika Päevad 2002, Kuressaare ooperipäevad 2002, Leigo järvemuusika 2002, Tallinna Orelifestival, Rapla kirikumuusika X festival 2002, Kuressaare kammermuusikapäevad 2002, Mart Saare muusikafestival, Credo 2002, Tartu vanamuusika IX festival, Trialogos 2002 (kultuurifestival), Fiesta de la guitarra (kitarrimuusika festival), Klaver 2002

  4. Schöneweide - neu kollagiert. Ein künstlerisches Forschungsprojekt

    Directory of Open Access Journals (Sweden)

    Albert Markert

    2015-04-01

    Full Text Available Der Berliner Stadtteil Schöneweide – einst AEG-Areal und Wiege der Elektrifizierung Berlins - war bis zur Wende einer der größten Industriestandorte Europas. Nach der Wende schlossen nahezu alle Industriebetriebe. Seitdem stehen die meisten Fabrikhallen leer. Seit einiger Zeit wandelt sich Oberschöneweide: Die Hochschule für Technik und Wirtschaft hat seit einigen Jahren hier ihren Hauptstandort; eine international expandierende Kunstgießerei hat eine neue Produktionsstätte eröffnet; der kanadische Rocksänger und Fotograf Bryan Adams plant, ein Kulturzentrum zum internationalen Austausch in einer der ehemaligen Produktionshallen zu etablieren. Seit einigen Jahren ziehen zahlreiche Designer_innen, Künstler_innen und Student_innen nach Schöneweide und prägen zunehmend das Erscheinungsbild des Stadtteils (...

  5. "Kas võib tõesti tulla Hommik?..." : [luuletused] / Emily Dickinson ; tõlk. Doris Kareva, Jüri Talvet

    Index Scriptorium Estoniae

    Dickinson, Emily

    2008-01-01

    Sisu: "Kas võib tõesti tulla Hommik?..." ; "Ta suri - nii ta surigi..." ; "On kuskil surematud Mäed..." ; "Likööri rüüpan võrratut..." ; "See linnuke on Lootus..." ; "Olen Eikeegi. Ja sina?..." ; "Ma tean, on piirat Aeg..." ; "Ma räägin kuidas tõusis Päev..." ; "On Kuudel lõpp - on Aastail - sõlm..." ; "Suur Hullus pühim mõistus on..." ; "Kui saabuksid sa Sügisel..." ; "Hing valib Seltsi ainuomase..." ; "Ma surin Ilu eest - just siis..." ; "Et mina ei saand peatuda..." ; "Surm, see on kahekõne vaid..." ; "Suur Lootus langes..." ; "Üht kaotust igavesti kandsin..." ; "Need kes on hauas viibinud kaua..." ; "See lõplikkusetunne..." ; "Jah - nende tabamatus..." ; "Lõid Maja ümber laksu vood..." ; "Ei pälvi kuigivõrd...". Elu- ja loomeloolisi andmeid autori kohta lk. 507-508

  6. Antiproton beam profile measurements using Gas Electron Multipliers

    CERN Document Server

    Pinto, Serge Duarte; Spanggaard, Jens; Tranquille, Gerard

    2011-01-01

    The new beam profile measurement for the Antiproton Decelerator (AD) at CERN is based on a single Gas Electron Multiplier (GEM) with a 2D readout structure. This detector is very light, ~0.4% X_0, as required by the low energy of the antiprotons, 5.3 MeV. This overcomes the problems previously encountered with multi-wire proportional chambers (MWPC) for the same purpose, where beam interactions with the detector severely affect the obtained profiles. A prototype was installed and successfully tested in late 2010, with another five detectors now installed in the ASACUSA and AEgIS beam lines. We will provide a detailed description of the detector and discuss the results obtained. The success of these detectors in the AD makes GEM-based detectors likely candidates for upgrade of the beam profile monitors in all experimental areas at CERN. The various types of MWPC currently in use are aging and becoming increasingly difficult to maintain.

  7. Two pioneering artists visit CERN

    CERN Multimedia

    CERN Bulletin

    2015-01-01

    On Monday, 19 January, CERN physicists welcomed musician Tim Blake - progressive rock keyboard and theremin player - and architectural lighting designer Patrice Warrener - inventor of the Chromolithe Polychromatic Illumination system, used in Lyon’s “Fête des Lumières”. Together, they make up the musical duo "Crystal Machine".   The artists visit the Antiproton Decelerator. (Image: Django Manglunki.)   Their visit began with an introduction to CERN by their friend Django Manglunki, project leader for the ion injector chain, and an improvised discussion on the LHC extraction system with Roger Barlow, kicker magnet controls expert and progressive rock fan. This was followed by a quick trip to the CCC, the server room and the SPS RF amplifiers in BA3. Next on the itinerary was a tour of the AD and anti-hydrogen experiments led by Michael Doser, AEgIS Spokesperson. A leisurely lunch followed, in the company ...

  8. Milne, a routine for the numerical solution of Milne's problem

    Science.gov (United States)

    Rawat, Ajay; Mohankumar, N.

    2010-11-01

    The routine Milne provides accurate numerical values for the classical Milne's problem of neutron transport for the planar one speed and isotropic scattering case. The solution is based on the Case eigen-function formalism. The relevant X functions are evaluated accurately by the Double Exponential quadrature. The calculated quantities are the extrapolation distance and the scalar and the angular fluxes. Also, the H function needed in astrophysical calculations is evaluated as a byproduct. Program summaryProgram title: Milne Catalogue identifier: AEGS_v1_0 Program summary URL:http://cpc.cs.qub.ac.uk/summaries/AEGS_v1_0.html Program obtainable from: CPC Program Library, Queen's University, Belfast, N. Ireland Licensing provisions: Standard CPC licence, http://cpc.cs.qub.ac.uk/licence/licence.html No. of lines in distributed program, including test data, etc.: 701 No. of bytes in distributed program, including test data, etc.: 6845 Distribution format: tar.gz Programming language: Fortran 77 Computer: PC under Linux or Windows Operating system: Ubuntu 8.04 (Kernel version 2.6.24-16-generic), Windows-XP Classification: 4.11, 21.1, 21.2 Nature of problem: The X functions are integral expressions. The convergence of these regular and Cauchy Principal Value integrals are impaired by the singularities of the integrand in the complex plane. The DE quadrature scheme tackles these singularities in a robust manner compared to the standard Gauss quadrature. Running time: The test included in the distribution takes a few seconds to run.

  9. Ligand binding modulates the structural dynamics and compactness of the major birch pollen allergen.

    Science.gov (United States)

    Grutsch, Sarina; Fuchs, Julian E; Freier, Regina; Kofler, Stefan; Bibi, Marium; Asam, Claudia; Wallner, Michael; Ferreira, Fátima; Brandstetter, Hans; Liedl, Klaus R; Tollinger, Martin

    2014-12-16

    Pathogenesis-related plant proteins of class-10 (PR-10) are essential for storage and transport of small molecules. A prominent member of the PR-10 family, the major birch pollen allergen Bet v 1, is the main cause of spring pollinosis in the temperate climate zone of the northern hemisphere. Bet v 1 binds various ligand molecules to its internal cavity, and immunologic effects of the presence of ligand have been discussed. However, the mechanism of binding has remained elusive. In this study, we show that in solution Bet v 1.0101 is conformationally heterogeneous and cannot be represented by a single structure. NMR relaxation data suggest that structural dynamics are fundamental for ligand access to the protein interior. Complex formation then leads to significant rigidification of the protein along with a compaction of its 3D structure. The data presented herein provide a structural basis for understanding the immunogenic and allergenic potential of ligand binding to Bet v 1 allergens.

  10. Properties of multilayer coatings produced by coaxial laser cladding

    Science.gov (United States)

    Petrovskiy, V. N.; Bykovskiy, D. P.; Dzhumaev, P. S.; Polskiy, V. I.; Prokopova, N. M.; Chirikov, S. N.

    2016-09-01

    This article contains results of the study of multilayer coatings produced by laser cladding on the substrate steel 34HMA using iron based powder PR-10R6M5 as the filler material. The coatings were produced with consistent application of the tracks with fixed overlapping. The dependencies between the characteristics of tracks and the technological mode of deposition were revealed. Properties of coatings were determined for various overlapping of tracks and directions of the cladding layers.

  11. Highly charged ions for atomic clocks, quantum information, and search for α variation.

    Science.gov (United States)

    Safronova, M S; Dzuba, V A; Flambaum, V V; Safronova, U I; Porsev, S G; Kozlov, M G

    2014-07-18

    We propose 10 highly charged ions as candidates for the development of next generation atomic clocks, quantum information, and search for α variation. They have long-lived metastable states with transition wavelengths to the ground state between 170-3000 nm, relatively simple electronic structure, stable isotopes, and high sensitivity to α variation (e.g., Sm(14+), Pr(10+), Sm(13+), Nd(10+)). We predict their properties crucial for the experimental exploration and highlight particularly attractive systems for these applications.

  12. [Molecular aspects of allergy to plant products. Part II. Pathogenesis-related proteins (PRs), apple allergenicity governed by Mal d 1 gene].

    Science.gov (United States)

    Bokszczanin, Kamila Ł; Przybyła, Andrzej A

    2012-03-01

    Of the plant allergens listed in the Official Allergen Database of the International Union of Immunological Societies, approximately 25% belong to the group of pathogenesis-related proteins (PRs). They have been classified into 17 PR families based on similarities in their amino acid sequence, enzymatic activities, or other functional properties. Plant-derived allergens have been identified with sequence similarities to PR families 2, 3, 4, 5, 8, 10, and 14. The main birch allergen in northern Europe is a class 10 (PR-10) protein from the European white birch (Betula pendula) termed Bet v 1. Pollen of other Fagales species contains PR-10 homologues that share epitopes with Bet v 1, as do several fruits, nuts and vegetables. Among the plant food fruits of the Rosaceae family are the most frequently responsible for allergenic reactions. It is documented, that approximately 2% of European population is allergic to apples. The article presents molecular characterization of PR-10 proteins with regard to their structure and function as well as apple Mal d 1 gene-determined allergenicity.

  13. The herbicide flumioxazin stimulates pathogenesis-related gene expression and enzyme activities in Vitis vinifera.

    Science.gov (United States)

    Castro, Antonio Jesús; Saladin, Gäelle; Bézier, Annie; Mazeyrat-Gourbeyre, Florence; Baillieul, Fabienne; Clément, Christophe

    2008-11-01

    In this work, the capacity of the soil-applied herbicide flumioxazin (fmx) to trigger defence mechanisms was assessed using 6-week-old in vitro grown Vitis vinifera L. plantlets. Time-course studies demonstrated that the herbicide induced the expression of basic beta-1,3-glucanase (Vvglu), basic chitinase (Vvchit1b) and PR10 (VvPR10.3) genes encoding three pathogenesis-related (PR) proteins involved in grapevine defence against pathogens. Thus, all transcripts accumulated in grapevine tissues to reach maximum values after 24-72 h of herbicide exposure, except for VvPR10.3 gene expression, which was induced in roots and stems but not in leaves. Induction of PR genes was observed to a greater extent in roots and leaves, and its intensity diminished in the stems although still remained noteworthy. The activities of beta-1,3-glucanase and chitinase enzymes significantly increased in the whole plant after herbicide exposure and were still stimulated 21 days after the beginning of treatments. Similarly, the most remarkable effect occurred in roots. However, all enzyme activities tested were stimulated in the upper aerial tissues as well, indicating that fmx or a derived product acts systemically, likely via root uptake.

  14. Screening and identification of putative allergens in berry fruits of the Rosaceae family: technical challenges.

    Science.gov (United States)

    Marzban, Gorji; Maghuly, Fatemeh; Herndl, Anita; Katinger, Hermann; Laimer, Margit

    2008-01-01

    Cross-reactive proteins in small fruits of the Rosaceae family like strawberry, raspberry and blackberry revealed an unexpected complex IgE-reactivity pattern. Several copies of PR-10 and PR-14 proteins were detected by Southern blots in strawberry, raspberry and blackberry. In raspberry, the highest similarity at the DNA level for PR-10 and PR-14 (Rub i 1 and Rub i 3) was detected to strawberry sequences of Fra a 1 and Fra a 3. At the protein level, Rub i 1 and Rub i 3 showed more than 70% identity with homologous proteins of rosaceous fruits. Furthermore, raspberries contained additional putative allergens, e.g. class III acidic chitinases and cyclophilins. Blackberries were shown to share at least two well-known major fruit allergens with other rosaceous fruits, namely PR-10s and PR-14s homologous proteins. However the IgE-reactive proteins of small fruits are still not extensively investigated. The main challenges in studying small fruit allergens are the complexity of the fruit matrix, the diversity of physico-chemical properties of fruit proteins, the lack of appropriate protein extraction procedures and the missing information about the influence of processing treatments on food components.

  15. Alterations of the myenteric plexus of the ileum and the descending colon caused by Toxoplasma gondii (genotype III Alterações do plexo mientérico do íleo e cólon descendente causadas por Toxoplasma gondii (genótipo III

    Directory of Open Access Journals (Sweden)

    Elaine Yae Yamashita Sugauara

    2008-09-01

    Full Text Available Alterations caused by a genotype III strain of Toxoplasma gondii were assessed with respect to the number and the morphometry of the myenteric neurons in the terminal ileum and the descending colon. Eighteen rats were divided into four groups: Acute Control Group (ACG, n=4; Acute Experimental Group (AEG, n=4; Chronic Control Group (CCG, n=5 and Chronic Experimental Group (CEG, n=5. NaCl solution was administered through gavage to the animals in the ACG and CCG. Toxoplasma gondii tachyzoites (10(4 from a genotype III strain were orally administered to the AEG and CEG. Acute Groups were died after 24 hours, and the Chronic Groups after 30 days. Neuronal loss was not observed in both organs. The neurons atrophied in the terminal ileum as the opposite occurred with the neurons at the descending colon during the chronic phase of infection. In the terminal ileum, the neurons atrophied during the chronic phase of the infection as no alteration was found during the acute phase. For the descending colon, the neurons became hypertrophic during the chronic infection in opposition to the atrophy found during the acute phase.Objetivou-se avaliar as alterações causadas por uma cepa genótipo III de Toxoplasma gondii, sobre o número e a morfometria de neurônios mientéricos, do íleo terminal e do cólon descendente. Dividiu-se dezoitos ratos em quatro grupos: controle agudo (GCA, n=4, experimental agudo (GEA, n=4, controle crônico (GCC, n=5 e experimental crônico (GEC, n=5. Os animais do GCA e GCC receberam solução de NaCl por gavagem, e os animais do GEA e GEC 10(4 taquizoítos de uma cepa genótipo III de T. gondii por via oral. Os grupos agudos após 24 horas foram mortos e os crônicos após 30 dias. Observou-se que não houve perda neuronal em ambos os órgãos. No íleo terminal, os neurônios atrofiaram-se na fase crônica da infecção, enquanto nenhuma alteração ocorreu na fase aguda. Já no cólon descendente, os neurônios tornaram

  16. Myenteric neuronal plasticity induced by Toxoplasma gondii (genotype III on the duodenum of rats

    Directory of Open Access Journals (Sweden)

    Rodrigo M. Papazian-Cabanas

    2012-09-01

    Full Text Available The effects of acute and chronic infection caused by Toxoplasma gondii on duodenal myenteric neurons were analyzed. Eighteen rats were assigned into four groups: Acute Control Group (ACG, n=4; Acute Experimental Group (AEG, n=4; Chronic Control Group (CCG, n=5; and Chronic Experimental Group (CEG, n=5. Rats from the AEG and CEG were inoculated orally with 105 genotype III (BTU-II strain tachyzoites of T. gondii isolated from a dog with neurological signs. Acute groups were killed after 24 hours after the inoculation and the chronic groups after 30 days. Whole-mount from the duodenum were stained with Giemsa. The population density of myenteric neurons, as well the body cell, nuclear and cytoplasmic area were analyzed. Both acute and chronic toxoplasmic infection did not provoke neuronal loss. On the other hand, plastic alterations were observed: decreasing of the nuclear and cytoplasmic area during the acute phase and neuronal hypertrophy during the chronic phase.Foram analisados os efeitos da infecção aguda e crônica provocada pelo Toxoplasma gondii sobre os neurônios mientéricos do duodeno. Dezoito ratos foram divididos em quatro grupos: Grupo Controle Agudo (GCA, n= 4, Grupo Experimental Agudo (GEA, n=4, Grupo Controle Crônico (GCC, n=5 e Grupo Experimental Crônico (GEC, n=5. Os animais do GEA e GEC receberam por via oral 10 5 taquizoítos de Toxoplasma gondii da cepa BTUII (genótipo III isolada de um cão com sintomatologia neurológica. Os grupos agudos foram submetidos à eutanásia após 24 horas e os crônicos após 30 dias da inoculação. Preparados totais do duodeno foram corados com Giemsa. A densidade populacional dos neurônios mientéricos, bem como a área do corpo celular, núcleo e citoplasma foram analisados. Ambas, as infecções toxoplásmicas aguda e crônica não provocaram a perda neuronal. Por outro lado, alterações plásticas foram observadas: diminuição da área nuclear e citoplasmática durante a fase

  17. Antioxidant capacity and fatty acid profile of Centaurea kotschyi (Boiss. & Heldr. Hayek var. persica (Boiss. Wagenitz from Turkey

    Directory of Open Access Journals (Sweden)

    Aktumsek, Abdurrahman

    2011-03-01

    Full Text Available The antioxidant capacity of the methanolic extract and the fatty acid composition of C. kotschyi var. persica were investigated. Six different chemical methods were used to determine the antioxidant capacity. The fatty acid composition was analyzed using gas chromatography. The IC50 value of the extract was determined as 37.09 μg/ml (in the DPPH assay. In the β-carotene/linoleic acid system, the extract exhibited 65.22% inhibition against linoleic acid oxidation. The amount of total phenolic content and total antioxidant capacity were detected as 36.52 mg gallic acid equivalent (GAE/g and 74.93 mg ascorbic acid equivalent (AE/g, respectively. The major fatty acid in the composition of C. kotschyi var. persica was found to be C 18:3 ω3 (α-linolenic acid by GC analysis. The results presented here indicate that C. kotschyi var. persica possess strong antioxidant properties. Therefore, the species can be used as a natural additive in food, cosmetic and pharmaceutical industries.La capacidad antioxidante de extractos metanólicos y composición de ácidos grasos de C. kotschyi var. pérsica fueron investigados. Seis métodos químicos diferentes fueron realizados para la determinación de la capacidad antioxidante. La composición de ácidos grasos fue analizada por cromatografía de gases. Los valores de IC50 de los extractos fueron 37.09 μg/ml (en el ensayo con DPPH. En el sistema β-carotene/ácido linoleico, el extracto mostró un 65.22% de inhibición frente a la oxidación del ácido linoleico. La cantidad total de contenido fenólico y capacidad antioxidante total fueron 36.52 mg equivalentes de ácido gallico (GAE/g y 74.93 mg equivalentes de ácido ascórbico (AE/g, respectivamente. El principal ácidos graso encontrado, por análisis de CG, en C. kotschyi var. pérsica fue el C 18:3 ω3 (ácido α-linolenico. Los resultados presentados aquí indican que C. kotschyi var. pérsica posee unas fuertes propiedades antioxidantes. Adem

  18. Tripper car 952 - a new machine for Hambach opencast mine; Bandschleifenwagen 952 - ein neues Geraet fuer den Tagebau Hambach

    Energy Technology Data Exchange (ETDEWEB)

    Friebe, J.

    1995-01-01

    In December 1991 Rheinbraun AG placed an order with the firm of TAKRAF Anlagen GmbH in Leipzig for the mechanical equipment of the new tripper car 952. An order for the electrical equipment was placed with AEG. As fas as outer dimensions and operating conditions are concerned, the new tripper car for Hambach opencast mine resembles its predecessors. Significant changes have however been introduced as regards certain details, and to some extent entirely new measures have been adopted, in particular with respect to the travel gear dynamics, the design and dimensions of the steel structure as regards fatigue strength, the belt alignment devices and the noise and dust emission control devices. On other respects, too, this tripper car is an innovation inasmuch as it is the first large opencast machine to be ordered by Rheinbraun directly from a manufacturer in the new Federal states. During construction, which took nearly 3 years, various differences of opinion between the contracting parties became evident as regards order handling, design and construction; the cause of these differences of opinion often only lies in the different developments that took place during the 40 years in which Germany was divided. Thanks to mutual efforts to overcome these differences as quickly as possible, the completion of the new tripper car 952 represents a project that has contributed to cooperation within the entire German brown coal industry and among its contractors. (orig.) [Deutsch] Im Dezember 1991 bestellte die Rheinbraun AG bei der Fa. TAKRAF Anlagen GmbH, Leipzig, den maschinentechnischen Teil des neuen Bandschleifenwagens 952. Fuer die elektrotechnische Ausruestung wurde der Auftrag an AEG vergeben. Der neue Bandschleifenwagen fuer den Tagebau Hambach entspricht in den aeusseren Abmessungen und in den Einsatzbedingungen den Vorgaengergeraeten. Im Detail sind jedoch wesentliche Aenderungen vorgenommen und zum Teil auch neue Wege beschritten worden, insbesondere im Bereich der

  19. Recent GPS Results at SLAC

    Energy Technology Data Exchange (ETDEWEB)

    Behrend, Dirk; Imfeld, Hans L.; /SLAC

    2005-08-17

    The Alignment Engineering Group (AEG) makes use of GPS technology for fulfilling part of its above ground surveying tasks at SLAC since early 2002. A base station (SLAC M40) has been set up at a central location of the SLAC campus serving both as master station for real-time kinematic (RTK) operations and as datum point for local GPS campaigns. The Leica RS500 system is running continuously and the GPS data are collected both externally (logging PC) and internally (receiver flashcard). The external logging is facilitated by a serial to Ethernet converter and an Ethernet connection at the station. Internal logging (ring buffer) is done for data security purposes. The weatherproof boxes for the instrumentation are excellent shelters against rain and wind, but do heat up considerably in sun light. Whereas the GPS receiver showed no problems, the Pacific Crest PDL 35 radio shut down several times due to overheating disrupting the RTK operations. In order to prevent heat-induced shutdowns, a protection against direct sun exposure (shading) and a constant air circulation system (ventilation) were installed. As no further shutdowns have occurred so far, it appears that the two measures successfully mended the heat problem.

  20. Fragmente "Lüürikast" / Wendy Saloman ; inglise keelest tlk. Doris Kareva

    Index Scriptorium Estoniae

    Saloman, Wendy

    2001-01-01

    Sisu : "Kannikesed olid kreeklaste surmalilled..."; "Foto kannikestest on hakanud äärtest keerduma. Leidsid nad lumest sel..."; "Kujutle Isist kogumas surnud Osirise tükke..."; "Kujutlus on igaviku tööriist..."; "Mäletada tuba tähendab mäletada mis tahes tuba hommikuvalgusega läbi..."; "Aeg muutis su ujedaks. Eebenipuust kell kaminasimsil meenutas sulle..."; "Kuidas saaksin mäletada tuba, mäletamata su puudumist..."; "Mälestus uhub üle su kuju nagu valguse mäng veel. Ometi, kui mõtlen..."; "Armastasime võimalust endis..."; "Kummaline on meenutada käte intiimsust: hoidjad ja avastajad, sõnade..."; "Vahel öeldakse, et kaamera on surma tööriist..."; "Nostalgia koondub su kujus..."; "Tamariskipuu hõrk hõng tõmbas Isise Byblosse..."; "Aprillis on hetki, mil koobaltsinine taevas on südame saadik..."; "Ja mõnegi meelest on Mercurius kaamera vaim ja fotograafia alkeemia..."; Isis öeldakse olevat muusadest esimene..."; "Suveregati kiirusel ummistab mälu Herakleitose jõe..."; "Möödunud ööl üllatasid mind unes..."; "Sõnad kargavad meelde, kaovad, kujutud fragmendid igavesest kogemusest..."

  1. STS-31 Hubble Space Telescope (HST) solar array (SA) mockup at MSFC, Alabama

    Science.gov (United States)

    1990-01-01

    A close-up shot shows an extravehicular mobility unit (EMU)-suited astronaut inspecting a solar array (SA) on the Hubble Space Telescope (HST) mockup in the Neutral Buoyancy Simulator (NBS) at the Marshall Space Flight Center (MSFC) in Huntsville, Alabama. MSFC managed the design and development of the telescope. The weightlessness simulator was used to practice SA contingency procedures that might be used in space. Astronauts also practiced SA servicing missions in the simulator which they will perform on the telescope in space. The solar arrays which supply electrical power to the space telescope were developed and contributed by the European Space Agency (ESA). ESA's two prime contractors were British Aerospace in England and AEG in West Germany. The two wing-like solar arrays contain 48,000 solar cells. They convert the sun's energy to electricity during that portion of an orbit when they are exposed to sunlight. The power is stored in six batteries to support the telescope during

  2. Sügis : [luuletused] / Mihhail Lermontov ; tlk. Marie Under, Villem Daniel, August Sang

    Index Scriptorium Estoniae

    Lermontov, Mihhail, 1814-1841

    2006-01-01

    Sisu: Sügis ; Monoloog ; Sõbrale ; Albumisse ; Eleegia ; Kevad ; Üksindus ; Minu maja ; Lained ja inimesed ; Stantsid ; "Kuigi arm on mind hüljanud ammu..." ; "Kui õhtul kaeblik leinakell..." ; Kuulsus ; "Võib-olla meenutad kord mind..." ; Ingel ; Romanss J...le ; "Kord saabub päev, kui kõigi süüdistatud..." ; "Kus mühavad Dnepri jõe rahutud vood..." ; "Mull̀ armas sinimägi-voor..." ; "Su ees ei saa ma alanduma..." ; Epitaaf ; "Ei, Byron, see ei ole ma..." ; "Aeg on südamele vaga..." ; "Ma õnne taevastelt ei palu..." ; Poeedi surm ; Vang ; Naaber ; "Kui kollendavad põllud lainetavad valla..." ; "Ma leidsin teise kaunitari..." ; "Ei taha, et mu saladust..." ; Poeet ; Ära usu end ; A. J. Odojevski mälestuseks ; Kolm palmi ; Palve ; Testament ; "Nii tihti pidudel, kus kirju hulk on koos..." ; Miks ; On igav ja kurb ; M. A. Shtsherbatovale ; Õhulaev ; Lapsele ; Pilved ; "Poolmaski alt täis saladust ja külma..." ; Kalju ; "Astun üksipäini oma rada..." ; Prohvet ; Leping ; "Ei, mitte sind ei imetle ma nii..." ; Puri. Eluloolisi andmeid autori kohta lk. 575

  3. Sillaraamatutest Soome poolt vaadates : ¡ Aino Kallas ja Urho Kekkonen / Sirje Olesk

    Index Scriptorium Estoniae

    Olesk, Sirje, 1954-

    2007-01-01

    Soome ja Eesti kultuuri- kirjandussuhetest läbi aja. Aino Kallase ja Krohnide kohta ilmunud uurimustest: Kukku Melkas. Historia halu ja Hedon käärme Aino Kallaksen tuotannossa (2006) ; Maarit Leskelä-Kärki. Kirjoittaen maailmassa. Krohnien sisarat ja kirjallinen elämä (2006); Pertti Lassila. Ihanteiden isänmaa. Julius Krohnin romanttinen fennomania ja kirjallisuus (2004). Eesti-Soome ühiste kirjandusseminaride kogumikest: Võimu võrgud ja vaimu kavalus = Vallan verkot ja hengen neurokkuus (1994); Mõtle luulest = Luule runosta (1996); Taasleitud aeg = Kadonneen ajan arvoitus (2000); Kaks teed kaasaega = Kaksi tietä nykyisyyteen (1999); Viron kirjallisuus vuosituhannen vahteessa. Postmodernia ja modernia (2000); Ametlik poliitika, mitteametlik suhtlemine. Soome ja Eesti suhete pöördekohti 1860-1991 = Virallista politiikkaa - epävirallista kanssakäymistä: Suomen ja Viron suhteiden käännekohtia 1860-1991 (1997); Soome ja Eesti. Koos ja eraldi = Suomi ja Viro. Yhdessä ja erikseen (1998); Hingesild = Sielunsilta (1998); Tartu = Tartto. Kirjailijan kaupunki (2003); Eesti. Mõisate, kirikute ja lilleväljade maa = Viro. Kartanoiden, kirkkojen ja kukkaketojen maa (2004)

  4. NATO Advanced Study Institute on Physical Processes in Laser-Materials Interaction, which was the 9th course of the Europhysics School of Quantum Electronics

    CERN Document Server

    1983-01-01

    It is a pleasure to write a few words as an introduction to the proceedings of the 1980 NATO ASI on "Physical Processes in Laser­ Naterial Interaction." This ASI is the ninth course of a series devoted to lasers and their applications, held under the responsibility of the Quantum Electronics Division of the European Physical Society, and for this reason known as the "Europhysics School of Quantum Electronics." Since 1971 the School has been operating with the joint direc­ tion of myself as representative of the academic research, and Dr. D. Roess (formerly with Siemens AEG, Munich, and now with Sick, Optik und Electronik, GmbH, Munich) for the industrial applications. Indeed the aim of the School is to alternate fundamental and applied frontier topics in the area of quantum electronics and modern optics, in order to introduce young research people from universities and industrial R&D laboratories to the new aspects of research opened by the laser.

  5. Constraints on Exotic Dipole-Dipole Couplings between Electrons at the Micrometer Scale

    Science.gov (United States)

    Kotler, Shlomi; Ozeri, Roee; Kimball, Derek F. Jackson

    2015-08-01

    New constraints on exotic dipole-dipole interactions between electrons at the micrometer scale are established, based on a recent measurement of the magnetic interaction between two trapped 88Sr+ ions. For light bosons (mass≤0.1 eV ) we obtain a 90% confidence interval for an axial-vector-mediated interaction strength of |gAegAe/4 π ℏc | ≤1.2 ×10-17 . Assuming C P T invariance, this constraint is compared to that on anomalous electron-positron interactions, derived from positronium hyperfine spectroscopy. We find that the electron-electron constraint is 6 orders of magnitude more stringent than the electron-positron counterpart. Bounds on pseudoscalar-mediated interaction as well as on torsion gravity are also derived and compared with previous work performed at different length scales. Our constraints benefit from the high controllability of the experimental system which contained only two trapped particles. It therefore suggests a useful new platform for exotic particle searches, complementing other experimental efforts.

  6. Antioxidant capacity and fatty acid profile of Centaurea kotschyi (Boiss. and Heldr.) Hayek var. persica (Boiss.) Wagenitz from Turkey

    Energy Technology Data Exchange (ETDEWEB)

    Zengin, G.; Guler, G.O.; Cakmak, Y.S.; Aktumseka, A.

    2011-07-01

    The antioxidant capacity of the methanolic extract and the fatty acid composition of C. kotschyi var. persica were investigated. Six different chemical methods were used to determine the antioxidant capacity. The fatty acid composition was analyzed using gas chromatography. The IC50 value of the extract was determined as 37.09 ig/ml (in the DPPH assay). In the {beta}carotene/linoleic acid system, the extract exhibited 65.22% inhibition against linoleic acid oxidation. The amount of total phenolic content and total antioxidant capacity were detected as 36.52 mg gallic acid equivalent (GAE)/g and 74.93 mg ascorbic acid equivalent (AE)/g, respectively. The major fatty acid in the composition of C. kotschyi var. persica was found to be C 18:3 u3 ({beta}-linolenic acid) by GC analysis. The results presented here indicate that C. kotschyi var. persica possess strong antioxidant properties. Therefore, the species can be used as a natural additive in food, cosmetic and pharmaceutical industries. (Author).

  7. Mathematical Descriptions of Axially Varying Penning Traps for the Antimatter Experiment: gravity, Interferometry, and Spectroscopy

    CERN Document Server

    Stephanie, Brown

    2015-01-01

    Antimatter, though proposed in 1933, is still not well understood. AEgIS aims to study the interaction of antihydrogen with the earth's gravitational field. This information will add to our understanding of the matter-antimatter asymmetry present in our universe. This paper discusses a Penning-Malmberg with a magnetic mirror that will hold $C_{2}^{-}$ that will be used for sympathetic cooling of antiprotons before the antihydrogen is created. The trap, which is critical to the cooling process of the antihydrogen, can be characterized by the separatrix between trapped and untrapped particles. This paper applies analytical processes used to define the separatrix of pure electron plasmas to a molecular plasma. Our work is based on the desire conditions (density, particle number, field strength, trap size) of the high field region. The initial application of a semi-analytical method applied to our trap defines the trap potential difference at \\~ 0.6V. The separatrix is defined in both the high and low fiel...

  8. Accuracy-energy configurable sensor processor and IoT device for long-term activity monitoring in rare-event sensing applications.

    Science.gov (United States)

    Park, Daejin; Cho, Jeonghun

    2014-01-01

    A specially designed sensor processor used as a main processor in IoT (internet-of-thing) device for the rare-event sensing applications is proposed. The IoT device including the proposed sensor processor performs the event-driven sensor data processing based on an accuracy-energy configurable event-quantization in architectural level. The received sensor signal is converted into a sequence of atomic events, which is extracted by the signal-to-atomic-event generator (AEG). Using an event signal processing unit (EPU) as an accelerator, the extracted atomic events are analyzed to build the final event. Instead of the sampled raw data transmission via internet, the proposed method delays the communication with a host system until a semantic pattern of the signal is identified as a final event. The proposed processor is implemented on a single chip, which is tightly coupled in bus connection level with a microcontroller using a 0.18 μm CMOS embedded-flash process. For experimental results, we evaluated the proposed sensor processor by using an IR- (infrared radio-) based signal reflection and sensor signal acquisition system. We successfully demonstrated that the expected power consumption is in the range of 20% to 50% compared to the result of the basement in case of allowing 10% accuracy error.

  9. Accuracy-Energy Configurable Sensor Processor and IoT Device for Long-Term Activity Monitoring in Rare-Event Sensing Applications

    Directory of Open Access Journals (Sweden)

    Daejin Park

    2014-01-01

    Full Text Available A specially designed sensor processor used as a main processor in IoT (internet-of-thing device for the rare-event sensing applications is proposed. The IoT device including the proposed sensor processor performs the event-driven sensor data processing based on an accuracy-energy configurable event-quantization in architectural level. The received sensor signal is converted into a sequence of atomic events, which is extracted by the signal-to-atomic-event generator (AEG. Using an event signal processing unit (EPU as an accelerator, the extracted atomic events are analyzed to build the final event. Instead of the sampled raw data transmission via internet, the proposed method delays the communication with a host system until a semantic pattern of the signal is identified as a final event. The proposed processor is implemented on a single chip, which is tightly coupled in bus connection level with a microcontroller using a 0.18 μm CMOS embedded-flash process. For experimental results, we evaluated the proposed sensor processor by using an IR- (infrared radio- based signal reflection and sensor signal acquisition system. We successfully demonstrated that the expected power consumption is in the range of 20% to 50% compared to the result of the basement in case of allowing 10% accuracy error.

  10. Direct detection of antiprotons with the Timepix3 in a new electrostatic selection beamline

    Science.gov (United States)

    Pacifico, N.; Aghion, S.; Alozy, J.; Amsler, C.; Ariga, A.; Ariga, T.; Bonomi, G.; Bräunig, P.; Bremer, J.; Brusa, R. S.; Cabaret, L.; Caccia, M.; Campbell, M.; Caravita, R.; Castelli, F.; Cerchiari, G.; Chlouba, K.; Cialdi, S.; Comparat, D.; Consolati, G.; Demetrio, A.; Di Noto, L.; Doser, M.; Dudarev, A.; Ereditato, A.; Evans, C.; Ferragut, R.; Fesel, J.; Fontana, A.; Gerber, S.; Giammarchi, M.; Gligorova, A.; Guatieri, F.; Haider, S.; Holmestad, H.; Huse, T.; Jordan, E.; Kellerbauer, A.; Kimura, M.; Krasnický, D.; Lagomarsino, V.; Lansonneur, P.; Lawler, G.; Lebrun, P.; Llopart, X.; Malbrunot, C.; Mariazzi, S.; Marx, L.; Matveev, V.; Mazzotta, Z.; Nebbia, G.; Nedelec, P.; Oberthaler, M.; Pagano, D.; Penasa, L.; Petracek, V.; Pistillo, C.; Prelz, F.; Prevedelli, M.; Ravelli, L.; Resch, L.; Røhne, O. M.; Rotondi, A.; Sacerdoti, M.; Sandaker, H.; Santoro, R.; Scampoli, P.; Smestad, L.; Sorrentino, F.; Spacek, M.; Storey, J.; Strojek, I. M.; Testera, G.; Tietje, I.; Tlustos, L.; Widmann, E.; Yzombard, P.; Zavatarelli, S.; Zmeskal, J.; Zurlo, N.

    2016-09-01

    We present here the first results obtained employing the Timepix3 for the detection and tagging of annihilations of low energy antiprotons. The Timepix3 is a recently developed hybrid pixel detector with advanced Time-of-Arrival and Time-over-Threshold capabilities and has the potential of allowing precise kinetic energy measurements of low energy charged particles from their time of flight. The tagging of the characteristic antiproton annihilation signature, already studied by our group, is enabled by the high spatial and energy resolution of this detector. In this study we have used a new, dedicated, energy selection beamline (GRACE). The line is symbiotic to the AEgIS experiment at the CERN Antiproton Decelerator and is dedicated to detector tests and possibly antiproton physics experiments. We show how the high resolution of the Timepix3 on the Time-of-Arrival and Time-over-Threshold information allows for a precise 3D reconstruction of the annihilation prongs. The presented results point at the potential use of the Timepix3 in antimatter-research experiments where a precise and unambiguous tagging of antiproton annihilations is required.

  11. FameLab International Final: a triumph for Switzerland and CERN

    CERN Multimedia

    CERN Bulletin

    2015-01-01

    Oskari Vinko, from ETH Zurich, who won the Swiss finals organised at CERN last May, is the winner of the 2015 FameLab competition. The CERN winner Lillian Smestad, member of the AEgIS collaboration from the Norwegian Research Council, shared second place with François-Xavier Joly from France, who also was among the trainees at the FameLab Master Classes organised by CERN in April.     CERN's Lillian Smestad (left) and Oskari Vinko from ETH Zurich, during the Swiss and CERN joint final, organised at CERN in May 2015. The 2015 FameLab International Final, which took place on 4 June in Cheltenham, UK, was a triumph for Switzerland and CERN! The competition was very hard this year, with 27 countries participating in the international semifinals and only nine making it through to the finals. This was also the first year that CERN took part as a “country”.  Congratulations to all the winners! To experience the international Famelab ...

  12. Beta-N-Methylamino-l-Alanine: LC-MS/MS Optimization, Screening of Cyanobacterial Strains and Occurrence in Shellfish from Thau, a French Mediterranean Lagoon

    Directory of Open Access Journals (Sweden)

    Damien Réveillon

    2014-11-01

    Full Text Available β-N-methylamino-l-alanine (BMAA is a neurotoxic non-protein amino acid suggested to be involved in neurodegenerative diseases. It was reported to be produced by cyanobacteria, but also found in edible aquatic organisms, thus raising concern of a widespread human exposure. However, the chemical analysis of BMAA and its isomers are controversial, mainly due to the lack of selectivity of the analytical methods. Using factorial design, we have optimized the chromatographic separation of underivatized analogues by a hydrophilic interaction chromatography coupled to tandem mass spectrometry (HILIC-MS/MS method. A combination of an effective solid phase extraction (SPE clean-up, appropriate chromatographic resolution and the use of specific mass spectral transitions allowed for the development of a highly selective and sensitive analytical procedure to identify and quantify BMAA and its isomers (in both free and total form in cyanobacteria and mollusk matrices (LOQ of 0.225 and 0.15 µg/g dry weight, respectively. Ten species of cyanobacteria (six are reported to be BMAA producers were screened with this method, and neither free nor bound BMAA could be found, while both free and bound DAB were present in almost all samples. Mussels and oysters collected in 2009 in the Thau Lagoon, France, were also screened, and bound BMAA and its two isomers, DAB and AEG, were observed in all samples (from 0.6 to 14.4 µg/g DW, while only several samples contained quantifiable free BMAA.

  13. A high-throughput assay for quantification of starch hydrolase inhibition based on turbidity measurement.

    Science.gov (United States)

    Liu, Tingting; Song, Lixia; Wang, Hongyu; Huang, Dejian

    2011-09-28

    A high-throughput method for rapid determination of starch hydrolase inhibition was developed using a 96-well microplate UV-vis reader to monitor the turbidity decrease over time. The area under the curve of turbidity measured over time was used to quantify the inhibitory effect of polyphenolic compounds on porcine pancreatic amylase, rat intestine α-glucosidase, and fungal amyloglucosidase. Acarbose equivalence (AE) was introduced for the first time and defined as IC50 of acarbose divided by the IC50 of the sample measured under the same 96-well plate. This way, the run-to-run variations are canceled out. Among the plant extracts tested, grape seed extracts (1,440 μmolAE/g) and cinnamon bark extracts (1600 μmolAE/g) are the most active in inhibiting rat intestine α-glucosidase. For porcine α-amylase inhibition, grape seed extracts (5710 μmol AE/g) are close to four times more active (equal weight basis) than acarbose (1550 μmolAE/g).

  14. Direct detection of antiprotons with the Timepix3 in a new electrostatic selection beamline

    Energy Technology Data Exchange (ETDEWEB)

    Pacifico, N., E-mail: nicola.pacifico@cern.ch [Institute of Physics and Technology, University of Bergen, Allgaten 55, 5007 Bergen (Norway); Aghion, S. [Politecnico of Milano, Piazza Leonardo da Vinci 32, 20133 Milano (Italy); INFN Milano, via Celoria 16, 20133 Milano (Italy); Alozy, J. [Physics Department, CERN, 1211 Geneva 23 (Switzerland); Amsler, C.; Ariga, A.; Ariga, T. [Laboratory for High Energy Physics, Albert Einstein Center for Fundamental Physics, University of Bern, 3012 Bern (Switzerland); Bonomi, G. [Department of Mechanical and Industrial Engineering, University of Brescia, via Branze 38, 25123 Brescia (Italy); INFN Pavia, via Bassi 6, 27100 Pavia (Italy); Bräunig, P. [Kirchhoff-Institute for Physics, Heidelberg University, Im Neuenheimer Feld 227, 69120 Heidelberg (Germany); Bremer, J. [Physics Department, CERN, 1211 Geneva 23 (Switzerland); Brusa, R.S. [Department of Physics, University of Trento, via Sommarive 14, 38123 Povo, Trento (Italy); TIFPA/INFN Trento, via Sommarive 14, 38123 Povo, Trento (Italy); Cabaret, L. [Laboratory Aimé Cotton, University of Paris-Sud, ENS Cachan, CNRS, University Paris-Saclay, 91405 Orsay Cedex (France); Caccia, M. [INFN Milano, via Celoria 16, 20133 Milano (Italy); Department of Science, University of Insubria, Via Valleggio 11, 22100 Como (Italy); Campbell, M. [Physics Department, CERN, 1211 Geneva 23 (Switzerland); Caravita, R. [Department of Physics, University of Genova, via Dodecaneso 33, 16146 Genova (Italy); INFN Genova, via Dodecaneso 33, 16146 Genova (Italy); Castelli, F. [INFN Milano, via Celoria 16, 20133 Milano (Italy); Department of Physics, University of Milano, via Celoria 16, 20133 Milano (Italy); Cerchiari, G. [Max Planck Institute for Nuclear Physics, Saupfercheckweg 1, 69117 Heidelberg (Germany); Chlouba, K. [Czech Technical University, Prague, Brehov 7, 11519 Prague 1 (Czech Republic); and others

    2016-09-21

    We present here the first results obtained employing the Timepix3 for the detection and tagging of annihilations of low energy antiprotons. The Timepix3 is a recently developed hybrid pixel detector with advanced Time-of-Arrival and Time-over-Threshold capabilities and has the potential of allowing precise kinetic energy measurements of low energy charged particles from their time of flight. The tagging of the characteristic antiproton annihilation signature, already studied by our group, is enabled by the high spatial and energy resolution of this detector. In this study we have used a new, dedicated, energy selection beamline (GRACE). The line is symbiotic to the AEgIS experiment at the CERN Antiproton Decelerator and is dedicated to detector tests and possibly antiproton physics experiments. We show how the high resolution of the Timepix3 on the Time-of-Arrival and Time-over-Threshold information allows for a precise 3D reconstruction of the annihilation prongs. The presented results point at the potential use of the Timepix3 in antimatter-research experiments where a precise and unambiguous tagging of antiproton annihilations is required.

  15. Vikergallup : eesti kirjandus 2008 / Peeter Helme, Ott Kilusk, Igor Kotjuh... [jt.

    Index Scriptorium Estoniae

    2009-01-01

    21 arvustaja vastus küsimusele, milline oli 2008. aasta parim uudisteos ja debüüt. Ära nimetati fs-i luulekogu "Alasti ja elus", Andrei Hvostovi proosaraamatut "Võõrad lood", Maarja Kangro luulekogu "Heureka", Kalju Kruusa luulekogu "Pilvedgi mindgi liigutavadgi", Asko Künnapi luulekogu "Su ööd on loetud", Elo Viidingu proosaraamatut "Püha Maama", Mart Juure luulekogu "Pane Eesti peale tagasi", Jaan Kaplisnki luulekogu "Teiselpool järve", Mart Kivastiku proosaraamatut "Kurb raamat", Leo Kunnase romaani "Gort Ashryn I", Andres Langemetsa luulekogu "Vooder", Erkki Luugi "Valitud luuletusi", Rein Põdra romaani "Juba olnud", Rein Raua lühiromaani "Vend" ja Jaan Tangsoo romaani "Méduse'i parv". Parima debüüdina mainiti Andrus Kasemaa luulekogu "Poeedirahu", Barthol Lo Mejori proosaraamatut "Popdada" ja Chaneldiori proosaraamatut "Kontrolli alt väljas", Lauri Saatpalu laulutekstiraamatut "Nähtused ja tehtused", Tamur Kusnetsi romaani "Hundipäikese aeg" ja Jaanika Merilo luulekogu "Rütmist väljas"

  16. Me saame hakkama! / Toomas Hendrik Ilves

    Index Scriptorium Estoniae

    Ilves, Toomas Hendrik, 1953-

    2009-01-01

    Vabariigi Presidendi tervitus 2008/2009. aastavahetusel. Ilmunud ka: Postimees 3. jaan. 2009, lk. 3, pealk.: President Toomas Hendrik Ilvese uusaastatervitus; Eesti Päevaleht 3. jaan. 2009, lk. 3, pealk.: Sajandi keerulisim aasta. Vt. samas: Muutunud aeg. Väljavõte presidendi uusaastakõnest 2007. aasta 31. detsembril; Oma Saar 3. jaan. 2009, lk. 5, pealk.: Armas rahvas!; Pärnu Postimees 3. jaan. 2009, lk. 5, pealk.: Vabariigi presidendi aastavahetuse tervitus; Võrumaa Teataja 3. jaan. 2009, lk. 2, pealk.: Vabariigi presidendi tervitus aastavahetusel 2008/2009; Virumaa Teataja 3. jaan. 2009, lk. 11, pealk.: Homne on meie teha; Järva Teataja 3. jaan. 2009, lk. 2, pealk.: Me tuleme toime; Hiiu Leht : Nädalalõpp 9. jaan. 2009, lk. 6, pealk.: Armas rahvas!; Meie Maa 3. jaan. 2009, lk. 2 (tsitaat kõnest); Vaba Eesti Sõna 8. jaan. 2009, lk. 3, pealk.: Vabariigi Presidendi tervitus aastavahetusel; Eesti Päevaleht (Stockholm) 14. jaan. 2009, lk. 1, pealk.: Toomas Hendrik Ilves: Jäägem raskuste kiuste ausaks; Eesti Elu 9. jaan. 2009, lk. 2, pealk.: Vabariigi Presidendi tervitus 2008/2009. aastavahetusel; Meie Kodu 21. jaan. 2009, lk. 1, pealk.: Vabariigi Presidendi tervitus 2008/2009. aastavahetusel; Eesti Hääl 24. jaan. 2009, lk. 1, pealk.: EV Presidendi kõne

  17. Space Power Program Semiannual Progress Report for period ending June 30, 1963

    Energy Technology Data Exchange (ETDEWEB)

    Miller, A. J. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    1963-10-11

    This is a report of progress on the Oak Ridge National Laboratory's research and development program on nuclear power plants for electrical power production in space vehicles. The work is carried out under AEG Reactor Experiments, Fuels, and Materials, and Reactor Component programs. Research and development work is under way on the stainless steel boiling-potassium reactor and the Medium Power Reactor Experiment, boiling alkali metal heat transfer, high-temperature and refractory alloys, fuel material, and space reactor shielding, particularly in connection with SNAP 2, 8, 10, and 50. Many of these OREL efforts are directed toward the development of a specific type of power plant, but they also furnish a significant contribution of scientific and engineering information needed in other programs on advanced SNAP systems. Progress on research and development directly related to the Medium Power Reactor Experiment (MPRE) is presented mostly in Part I of this report. Progress on the MPRE will, in the future, be reported on a quarterly basis. The form of the reporting will alternate from MPRE Quarterly Progress Reports to Space Power Semiannual Progress Reports.

  18. The transcription factor VvWRKY33 is involved in the regulation of grapevine (Vitis vinifera) defense against the oomycete pathogen Plasmopara viticola.

    Science.gov (United States)

    Merz, Patrick R; Moser, Tina; Höll, Janine; Kortekamp, Andreas; Buchholz, Günther; Zyprian, Eva; Bogs, Jochen

    2015-03-01

    Grapevine (Vitis vinifera ssp. vinifera) is one of the most important fruit species; however, it is highly susceptible to various pathogens, which can cause severe crop losses in viticulture. It has been shown that several WRKY class transcription factors (TFs) are part of the signal transduction cascade, which leads to the activation of plant defense reactions against various pathogens. In the present investigation, a full-length cDNA was isolated from V. vinifera leaf tissue encoding a predicted protein, designated VvWRKY33, which shows the characteristics of group I WRKY protein family. VvWRKY33 induction correlates with the expression of VvPR10.1 (pathogenesis-related 10.1) gene in the leaves of the resistant cultivar 'Regent' after infection with Plasmopara viticola, whereas in the susceptible cultivar 'Lemberger' VvWRKY33 and VvPR10.1 are not induced. Corresponding expression of the TF and VvPR10.1 was even obtained in uninfected ripening berries. In planta, analysis of VvWRKY33 has been performed by ectopic expression of VvWRKY33 in grapevine leaves of greenhouse plants mediated via Agrobacterium tumefaciens transformation. In consequence, VvWRKY33 strongly increases resistance to P. viticola in the susceptible cultivar 'Shiraz' and reduces pathogen sporulation of about 50-70%, indicating a functional role for resistance in grapevine. Complementation of the resistance-deficient Arabidopsis thaliana Columbia-0 (Col-0) mutant line wrky33-1 by constitutive expression of VvWRKY33 restores resistance against Botrytis cinerea to wild-type level and in some complemented mutant lines even exceeds the resistance level of the parental line Col-0. Our results support the involvement of VvWRKY33 in the defense reaction of grapevine against different pathogens.

  19. 淋巴结转移数目和淋巴结转移率对食管胃结合部腺癌根治术后预后的影响%Effect of number of metastatic lymph nodes and metastatic lymph node ratio on the prognosis in patients with adenocarcinoma of the esophagogastric junction after curative resection

    Institute of Scientific and Technical Information of China (English)

    张洪典; 陈传贵; 岳杰; 马明全; 马钊; 于振涛

    2014-01-01

    Objective To analyze the effects of number of positive lymph nodes and metastatic lymph node ratio (LNR) in evaluation of recurrence risk and overall survival in patients with adenocarcinoma of the esophagogastric junction (AEG) after curative resection.Methods Clinical data of 337 AEG patients who underwent curative resection in our hospital were retrospectively reviewed.The pN stage was categorized based on the number of metastatic lymph nodes and LNR stage,and was determined by the best cutoff approach at log-rank test.Univariate Kaplan-Meier survival analysis and multivariate Cox proportional hazard model were used to analyze the effects of pN and LNR on recurrence-free survival and overall survival of these patients.Receiver operating characteristic (ROC) curves were plotted to compare the accuracy of prognosis prediction with pN and LNR.Results The 5-year recurrence-free survival rate and overall survival rate for all patients were 25.5% and 29.9%,respectively.The 5-year recurrence-free survival rates were 47.6%,23.2%,17.1% and 5.7% for pN0,pN1,pN2,and pN3,respectively,(P<0.001) and the 5-year overall survival rates were 53.3%,28.9%,18.9% and 7.3%,respectively (P < 0.001).The 5-year recurrence-free survival rates were 47.6%,24.3%,11.4% and 2.0% for LNR0,LNR1,LNR2,and LNR3,respectively (P < 0.001),and the 5-year overall survival rates were 53.3%,28.5%,15.0%,2.6%,respectively (P <0.001).Univariate analysis showed that tumor size,macroscopic type,degree of differentiation,pT,pN,LNR and TNM stage were significantly associated with RFS and OS (P < 0.05).Cox multivariate analysis showed that either pN or LNR was independent risk factor for RFS and OS (P <0.001).When pN and LNR were entered into the Cox hazard ratio model as covariates at the same time,LNR remained as an independent prognosis factor for RFS and OS (P < 0.001),but pN was not (P > 0.05).ROC curves showed that the area under the curve of LNR stage was

  20. Seven different genes encode a diverse mixture of isoforms of Bet v 1, the major birch pollen allergen

    Directory of Open Access Journals (Sweden)

    Gilissen Ludovicus JWJ

    2006-07-01

    Full Text Available Abstract Background Pollen of the European white birch (Betula pendula, syn. B. verrucosa is an important cause of hay fever. The main allergen is Bet v 1, member of the pathogenesis-related class 10 (PR-10 multigene family. To establish the number of PR-10/Bet v 1 genes and the isoform diversity within a single tree, PCR amplification, cloning and sequencing of PR-10 genes was performed on two diploid B. pendula cultivars and one interspecific tetraploid Betula hybrid. Sequences were attributed to putative genes based on sequence identity and intron length. Information on transcription was derived by comparison with homologous cDNA sequences available in GenBank/EMBL/DDJB. PCR-cloning of multigene families is accompanied by a high risk for the occurrence of PCR recombination artifacts. We screened for and excluded these artifacts, and also detected putative artifact sequences among database sequences. Results Forty-four different PR-10 sequences were recovered from B. pendula and assigned to thirteen putative genes. Sequence homology suggests that three genes were transcribed in somatic tissue and seven genes in pollen. The transcription of three other genes remains unknown. In total, fourteen different Bet v 1-type isoforms were identified in the three cultivars, of which nine isoforms were entirely new. Isoforms with high and low IgE-reactivity are encoded by different genes and one birch pollen grain has the genetic background to produce a mixture of isoforms with varying IgE-reactivity. Allergen diversity is even higher in the interspecific tetraploid hybrid, consistent with the presence of two genomes. Conclusion Isoforms of the major birch allergen Bet v 1 are encoded by multiple genes, and we propose to name them accordingly. The present characterization of the Bet v 1 genes provides a framework for the screening of specific Bet v 1 genes among other B. pendula cultivars or Betula species, and for future breeding for trees with a reduced

  1. The landscape of cytokinin binding by a plant nodulin

    Energy Technology Data Exchange (ETDEWEB)

    Ruszkowski, M.; Szpotkowski, K.; Sikorski, M. [Polish Academy of Sciences, Poznan (Poland); Jaskolski, M., E-mail: mariuszj@amu.edu.pl [Polish Academy of Sciences, Poznan (Poland); A. Mickiewicz University, Poznan (Poland)

    2013-12-01

    The crystal structures of complexes of M. truncatula nodulin 13 with four cytokinins, trans-zeatin, N{sup 6}-isopentenyladenine, kinetin and N{sup 6}-benzyladenine, show an unusual mode of dimerization of this PR-10-fold plant protein. The cytokinin-binding mode in the internal cavity of the protein is the same in each complex and resembles the pattern found in the cytokinin receptor protein. Nodulation is an extraordinary symbiotic interaction between leguminous plants and nitrogen-fixing bacteria (rhizobia) that assimilate atmospheric nitrogen (in root nodules) and convert it into compounds suitable for the plant host. A class of plant hormones called cytokinins are involved in the nodulation process. In the model legume Medicago truncatula, nodulin 13 (MtN13), which belongs to the pathogenesis-related proteins of class 10 (PR-10), is expressed in the outer cortex of the nodules. In general, PR-10 proteins are small and monomeric and have a characteristic fold with an internal hydrophobic cavity formed between a seven-stranded antiparallel β-sheet and a C-terminal α-helix. Previously, some PR-10 proteins not related to nodulation were found to bind cytokinins such as trans-zeatin. Here, four crystal structures of the MtN13 protein are reported in complexes with several cytokinins, namely trans-zeatin, N{sup 6}-isopentenyladenine, kinetin and N{sup 6}-benzyladenine. All four phytohormones are bound in the hydrophobic cavity in the same manner and have excellent definition in the electron-density maps. The binding of the cytokinins appears to be strong and specific and is reinforced by several hydrogen bonds. Although the binding stoichiometry is 1:1, the complex is actually dimeric, with a cytokinin molecule bound in each subunit. The ligand-binding site in each cavity is formed with the participation of a loop element from the other subunit, which plugs the only entrance to the cavity. Interestingly, a homodimer of MtN13 is also formed in solution, as confirmed

  2. Promotion effect of cobalt-based catalyst with rare earth for the ethanol steam reforming

    Science.gov (United States)

    Chiou, Josh Y. Z.; Chen, Ya-Ping; Yu, Shen-Wei; Wang, Chen-Bin

    2013-12-01

    Catalytic performance of ethanol steam reforming (ESR) was investigated on praseodymium (Pr) modified ceria-supported cobalt oxide catalyst. The ceria-supported cobalt oxide (Ce-Co) catalyst was prepared by co-precipitation-oxidation (CPO) method, and the doped Pr (5 and 10 wt% loading) catalysts (Pr5-Ce-Co and Pr10-Ce-Co) were prepared by incipient wetness impregnation method. The reduction pretreatment under 250 and 400 °C (H250 and H400) was also studied. All samples were characterized by XRD, TPR and TEM. Catalytic performance of ESR was tested from 250 to 500 °C in a fixed-bed reactor. The doping of Pr into the ceria lattice has significantly promoted the activity and reduced the coke formation. The products distribution also can be influenced by the different reduction pretreatment. The Pr10-Ce-Co-H400 sample is a preferential ESR catalyst, where the hydrogen distribution approaches 73% at 475 °C with less amounts (< 2%) of CO and CH4.

  3. Ligand Binding Modulates the Structural Dynamics and Compactness of the Major Birch Pollen Allergen

    Science.gov (United States)

    Grutsch, Sarina; Fuchs, Julian E.; Freier, Regina; Kofler, Stefan; Bibi, Marium; Asam, Claudia; Wallner, Michael; Ferreira, Fátima; Brandstetter, Hans; Liedl, Klaus R.; Tollinger, Martin

    2014-01-01

    Pathogenesis-related plant proteins of class-10 (PR-10) are essential for storage and transport of small molecules. A prominent member of the PR-10 family, the major birch pollen allergen Bet v 1, is the main cause of spring pollinosis in the temperate climate zone of the northern hemisphere. Bet v 1 binds various ligand molecules to its internal cavity, and immunologic effects of the presence of ligand have been discussed. However, the mechanism of binding has remained elusive. In this study, we show that in solution Bet v 1.0101 is conformationally heterogeneous and cannot be represented by a single structure. NMR relaxation data suggest that structural dynamics are fundamental for ligand access to the protein interior. Complex formation then leads to significant rigidification of the protein along with a compaction of its 3D structure. The data presented herein provide a structural basis for understanding the immunogenic and allergenic potential of ligand binding to Bet v 1 allergens. PMID:25517162

  4. Prospecting plant growth promoting bacteria and cyanobacteria as options for enrichment of macro- and micronutrients in grains in rice–wheat cropping sequence

    Directory of Open Access Journals (Sweden)

    Anuj Rana

    2015-12-01

    Full Text Available The influence of plant growth promoting bacteria (PGPB and cyanobacteria, alone and in combination, was investigated on micronutrient enrichment and yield in rice–wheat sequence, over a period of two years. Analysis of variance (ANOVA in both crops indicated significant differences in soil dehydrogenase activity and micronutrient enrichment in grains (Fe, Zn in rice, and Cu, Mn in wheat. The combined inoculation of Anabaena oscillarioides CR3, Brevundimonas diminuta PR7, and Ochrobactrum anthropi PR10 (T6 significantly increased nitrogen, phosphorus, and potassium (NPK content and improved rice yield by 21.2%, as compared to the application of recommended dose of NPK fertilizers (T2. The treatment T5 (Providencia sp. PR3 + B. diminuta PR7 + O. anthropi PR10 recorded an enhancement of 13–16% in Fe, Zn, Cu, and Mn concentrations, respectively, in rice grains. In wheat, Providencia sp. PW5 (T6 recorded the highest yield (5.23 Mg ha−1 and significantly higher enrichment of Fe and Cu (44–45% in the grains. This study highlighted the promise of combinations of cyanobacteria/bacteria and their synergistic action in biofortification and providing savings of 40–60 kg N ha−1. Future focus needs to be towards integrating such promising environment-friendly and environmentally sustainable options in nutrient management strategies for this cropping sequence.

  5. Correlation and quantitative trait loci analyses of total chlorophyll content and photosynthetic rate of rice (Oryza sativa) under water stress and well-watered conditions.

    Science.gov (United States)

    Hu, Song-Ping; Zhou, Ying; Zhang, Lin; Zhu, Xiu-Dong; Li, Lin; Luo, Li-Jun; Liu, Guo-Lan; Zhou, Qing-Ming

    2009-09-01

    In order to explore the relevant molecular genetic mechanisms of photosynthetic rate (PR) and chlorophyll content (CC) in rice (Oryza sativa L.), we conducted a series of related experiments using a population of recombinant inbred lines (Zhenshan97B x IRAT109). We found a significant correlation between CC and PR (R= 0.19**) in well-watered conditions, but no significant correlation during water stress (r= 0.08). We detected 13 main quantitative trait loci (QTLs) located on chromosomes 1, 2, 3, 4, 5, 6, and 10, which were associated with CC, including six QTLs located on chromosomes 1, 2, 3, 4, and 5 during water stress, and seven QTLs located on chromosomes 2, 3, 4, 6, and 10 in well-watered conditions. These QTLs explained 47.39% of phenotypic variation during water stress and 56.19% in well-watered conditions. We detected four main QTLs associated with PR; three of them (qPR2, qPR10, qPR11) were located on chromosomes 2, 10, and 11 during water stress, and one (qPR10) was located on chromosome 10 in well-watered conditions. These QTLs explained 34.37% and 18.41% of the phenotypic variation in water stress and well-watered conditions, respectively. In total, CC was largely controlled by main QTLs, and PR was mainly controlled by epistatic QTL pairs.

  6. Effects of temperature during soybean seed development on defense-related gene expression and fungal pathogen accumulation.

    Science.gov (United States)

    Upchurch, Robert G; Ramirez, Martha E

    2011-12-01

    Soybean [Glycine max (L.) Merr] plants were exposed to three temperature regimens during seed development to investigate the effect of temperature on the expression of eight defense-related genes and the accumulation of two fungal pathogens in inoculated seeds. In seeds prior to inoculation, either a day/night warm (34/26 °C) or a cool temperature (22/18 °C) relative to normal (26/22 °C) resulted in altered patterns of gene expression including substantially lower expression of PR1, PR3 and PR10. After seed inoculation with Cercospora kikuchii, pathogen accumulation was lowest in seeds produced at 22/18 °C in which of all defense genes, MMP2 was uniquely most highly induced. For seeds inoculated with Diaporthe phaseolorum, pathogen accumulation was lowest in seeds produced at 34/26 °C in which of all defense genes, PR10 was uniquely most highly induced. Our detached seed assays clearly demonstrated that the temperature regimens we applied during seed development produced significant changes in seed defense-related gene expression both pre- and post inoculation and our findings support the hypothesis that global climate change may alter plant-pathogen interactions and thereby potentially crop productivity.

  7. Development of integrated superconducting devices for signal preprocessing. Final report; Entwicklung supraleitender Bausteine der Signalvorverarbeitung. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Biehl, M.; Koch, R.; Neuhaus, M.; Scherer, T.; Jutzi, W.

    1998-02-01

    SPICE and CADENCE based tools for designing, simulating and optimizing SFQ and RSFQ circuits have been developed as well as a standard cell library corresponding to the fabrication technology established at the IEGI. A 12 bit flux shuttle shift register using Nb/Al Josephson junctions with a new write and readout gate has been fabricated and tested successfully; the power dissipation is 9 nW/bit/GHz. A pseudo random pulse generator was developed correspondingly. Simulations of RSFQ toggle flipflops during a large number of clock cycles demonstrated that the digital performance of counters is limited to clock frequencies below 100 GHz by dynamic effects, especially of parasitic inductances. Therefore dc measurements based on the voltage-frequency Josephson relationship must be followed by real time measurements of single SFQ word pulses. A four stage Nb based RSFQ counter in a coplanar waveguide test jig was tested up to a frequency of 2 GHz, limited by the available 32 bit pattern generator and the bandwith of the sampling oscilloscope, yielding bit error rates of about 10{sup -12}. Using YBCO technology, a 4 bit SFQ shift register (T=40 K) as well as miniaturized coplanar microwave devices for satellite and communication applications at 10 GHz (T=77 K) have been designed and fabricated. A 4 bit instantaneous real time frequency meter (IFM) and a microwave filter with a 3-dB bandwidth of only 1.8% have been mounted on the cold head of a split-cycle Stirling cooler (AEG, 1.5 W rate at 80 K) and tested successfully. Hybrid devices, e.g. amplifiers and oscillators, combining active semiconductor components and low loss coplanar YBCO transmission lines operated at 77 K seem very promising. (orig.) [Deutsch] Werkzeuge der Auslegung, Simulation und Optimierung von SFQ- und RSFQ-Schaltungen auf der Basis von SPICE und CADENCE wurden am IEGI entwickelt und eingesetzt. Eine auf die Technologien des Instituts zugeschnittene Bibliothek von Zellen ist vorhanden. Mit der

  8. "Me oma kõrgust eal ei tea..." : [luuletused] / Emily Dickinson ; tlk. Doris Kareva

    Index Scriptorium Estoniae

    Dickinson, Emily

    2006-01-01

    Sisu: "Me oma kõrgust eal ei tea..." ; "Ma tulen! - silme ees..." ; "Et mina ei saand peatuda..." ; "Surm see on kahekõne vaid..." ; "Ma surin Ilu eest - ent Kirst..." ; "Olen Eikeegi. Ja sina..." ; "Ei pälvi kuigivõrd..." ; "Kas võib tõesti tulla Hommik..." ; "Lilled - noh, kui ükski suudaks..." ; "Kui kogu elu kurbused..." ; "Ei eales enam - Tavalist..." ; "Üht kaotust igavesti kandsin..." ; "Suur Lootus langes..." ; "Kui säästa saan üht Surmavalu..." ; "See linnuke on Lootus..." ; "Ma olin Aastaid nälginud..." ; "Maist õnne magusaimaks..." ; "Kui Räitsakas..." ; "Ma olin Maja mannetuim..." ; "Ma elan Võimaluses..." ; "Hing valib Seltsi ainuomase..." ; "On tühja taeva üksildus..." ; "Need, kes on hauas viibinud kaua..." ; "Haud haljas Roheline on..." ; "See lõplikkusetunne..." ; "Muud Elu pole mul..." ; "Oo öö! Oo Öö..." ; "Ei söanda sõbrast lahkuda..." ; "Küll kõigest kõnelesime..." ; "Ta suri - nii ta surigi..." ; "Mis kartsime see tuligi..." ; "Kui sureb sõber kellelgi..." ; "Surm - võtab vaevalt viivu..." ; ""Aeg ravib haavad" öeldakse..." ; "Jah - nende tabamatus..." ; "Hää vaadata on tagasi..." ; "On Elu ja on Eluvorm..." ; "Hõiska - suur torm on möödas..." ; "Septembri Kandidaadikraad..." ; "Ma mõõdan iga Kannatust..." ; "Silm harjub Pimedusega..." ; "Kaks korda elu sulges end..." ; "Kõik ütle, kõik kuid kõverdi..." ; "Ma kardan Meest kel napp on Jutt..." ; "Kes võitleb üksi rahva ees..." ; "Võib näida vaieldamatu..." ; "On uppumisest armetum..." ; "Kergelt astus kõrge täht..." ; "Tee Värav valla, Surm! ; "See on mu kiri ilmale...". Eluloolisi andmeid autori kohta lk. 767

  9. Mu isamaa on minu arm : [luuletused] / Lydia Koidula ; [Impressioonid]: Viiu Härm

    Index Scriptorium Estoniae

    Koidula, Lydia, pseud., 1843-1886

    2004-01-01

    Sisu: Mu isamaa on minu arm! ; Eestimaa ; Eestimaa, su hiilgav rada ; Õpetus ; Veel! ; Ülesse unest! ; Ta aina sirgub usalduse rinnal ; Igatsus ; Isamaast ikka! ; Õige! ; Halasta! ; Teretus ; See on su isamaa! ; Üks ; Kaebus ; Kallim kingitus ; Eesti naine ; Kodu ; Miks sa nutad? ; Jutt ; Puhtad pihud ; Mul seisab meeles alati ; Ei jäänud ; Üht eesti laulu ; Mu isamaa, nad olid matnud ; Üksmeel ; Neid austa! ; Emajõe kaldal ; Eesti kotkas ; Sind surmani ; Tulge! ; Eesti muld ja eesti süda ; Sinu külge! ; Isamaa, usk, rahvas! ; Laulu sisu ; Tule! ; Teretus ; Jälle isamaa! ; Mõtted Toomemäel ; Ära looda, et sind usun ; Pühapäeva kellad ; Kosjakased ; Kaks selget silma ; Kõik muutunud ; Kase varjul kogemata ; Laulupisarad ; Kui ta teaks ; Kui vähe! ; Kadunud ; Laulu allikas ; Kaljukiri ; Näed kõrgeid pilvi - ; Ööbik ; Pikalt kiigub paadike ; Tee lahti! ; Aeg ; Ilu ; Noormehe igatsus ; Kolm sõna ; Hoia oma õnne! ; Kui sa kuulsid ; Igatsus ; Haual ; Kurtes ; Neiu kanga juures ; Hällilaul ; Õnn ; Südame põhjas ; Ülejäänud ; Puhkama ; Õhtul ; Lootus ; Lähedal ; Ema süda ; Saeveski ; Sügisemõtteid ; Kasepuu ; Kevade on sala tulnud ; Kuu ja künnilind ; Linnu lennul ; Ööbik ; Õhtu rahu ; Kuningas kevade ; Tühi pesa ; Järv ; Täis laulu ; Õhtu pühitsus ; Rüütli mõrsja ; Narva neitsi ; Akadeemik dr. F. J. Wiedemann'ile ; Sõber ; Palu andeks! ; Kuningatel kümme kinki ; Tasa, tasa! ; Küsimused ; Mälestus ; Koidula õnn ; Ümber ühe ilmakera; Ise ; Enne surma Eestimaale

  10. Participation of epididymal cysteine-rich secretory proteins in sperm-egg fusion and their potential use for male fertility regulation

    Institute of Scientific and Technical Information of China (English)

    Debora J. Cohen; Vanina G. Da Ros; Dolores Busso; Diego A. Ellerman; Julieta A. Maldera; Nadia Goldweic; Patricia S. Cuasnicú

    2007-01-01

    Rat protein DE is an androgen-dependent cysteine-rich secretory protein (CRISP) synthesized by proximal epididymal regions. DE, also known as CRISP- 1, is localized on the equatorial segment of acrosome-reacted spermatozoa and participates in gamete fusion through binding to egg complementary sites. Immunization of rats with DE inhibits fertility and sperm fusion ability, suggesting that DE represents a good epididymal contraceptive target.Recombinant DE fragments and synthetic peptides revealed that DE binds to the egg via a 12-amino acid region of an evolutionarily conserved motif, Signature 2 (S2). The ability of other CRISP to bind to the rat egg was correlated with their S2 amino acid sequences. Although testicular protein Tpx-1 (CRISP-2) was capable of binding to rodent eggs,human epididymal AEG-related protein (ARP) and helothermine (from lizard saliva) were not. The S2 region presented only two substitutions in Tpx-1 and four in ARP and helothermine, compared with the DE S2, suggesting that this amino acid sequence was relevant for egg interaction. Studies with Tpx-1 and anti-Tpx-1 revealed the participation of this protein in gamete fusion through binding to complementary sites in the egg. In competition studies, DE reduced binding of Tpx- 1 dose-dependently, indicating that both CRISP share the egg complementary sites. That anti-DE and anti-Tpx-1 inhibit sperm-egg fusion while recognizing only the corresponding proteins, suggests functional cooperation between these homologous CRISP to ensure fertilization success. These results increase our understanding of the molecular mechanisms of gamete fusion and contribute to the development of new and safer fertility regulating methods.

  11. Cyanobacteria and cyanotoxins are present in drinking water impoundments and groundwater wells in desert environments.

    Science.gov (United States)

    Chatziefthimiou, Aspassia D; Metcalf, James S; Glover, W Broc; Banack, Sandra A; Dargham, Soha R; Richer, Renee A

    2016-05-01

    Desert environments and drylands experience a drastic scarcity of water resources. To alleviate dependence on freshwater for drinking water needs, countries have invested in infrastructure development of desalination plants. Collectively, the countries of the Arabian Gulf produce 45% of the world's desalinated water, which is stored in dams, mega-reservoirs and secondary house water tanks to secure drinking water beyond daily needs. Improper storage practices of drinking water in impoundments concomitant with increased temperatures and light penetration may promote the growth of cyanobacteria and accumulation of cyanotoxins. To shed light on this previously unexplored research area in desert environments, we examined drinking and irrigation water of urban and rural environments to determine whether cyanobacteria and cyanotoxins are present, and what are the storage and transportation practices as well as the environmental parameters that best predict their presence. Cyanobacteria were present in 80% of the urban and 33% of the rural water impoundments. Neurotoxins BMAA, DAB and anatoxin-a(S) were not detected in any of the water samples, although they have been found to accumulate in the desert soils, which suggests a bioaccumulation potential if they are leached into the aquifer. A toxic BMAA isomer, AEG, was found in 91.7% of rural but none of the urban water samples and correlated with water-truck transportation, light exposure and chloride ions. The hepatotoxic cyanotoxin microcystin-LR was present in the majority of all sampled impoundments, surpassing the WHO provisional guideline of 1 μg/l in 30% of the urban water tanks. Finally, we discuss possible management strategies to improve storage and transportation practices in order to minimize exposure to cyanobacteria and cyanotoxins, and actions to promote sustainable use of limited water resources.

  12. 52 years of Kahl pilot nuclear power station. A special chapter in German technology history come to an end; 52 Jahre Versuchsatomkraftwerk Kahl. Ein besonderes Kapitel deutscher Technikgeschichte ist zu Ende

    Energy Technology Data Exchange (ETDEWEB)

    Hackel, Walter [VAK GmbH, Karlstein am Main (Germany)

    2011-06-15

    Since October 2010, the site of the former Kahl Experimental Nuclear Power Station (VAK) has been returned to the desired green-field condition. A special chapter in the German history of the use of nuclear power, which has played a major role in the technical and economic development of this energy resource, has come to an end after 52 years. When nuclear power pioneer Heinrich Mandel ordered VAK from AEG in 1958, the mood associated with using this source of energy was different from what it is now. Politicians of all parties were euphoric about the use of nuclear power, while power plant operators were more reluctant. Finally, also RWE was convinced and planned the construction of VAK as a joint venture with the Bayernwerk AG (now E.ON) utility in Grosswelzheim, Bavaria. The objective was clear: 'The order was placed so that the atomic power plant to be built could be used to accumulate experience in planning, operation, in capital cost and operating cost.' After a construction period of only 29 months, VAK was commissioned on November 13, 1960 as the first German nuclear power plant. The US-designed boiling water reactor had been designed for a power of 16,000 kilowatt. After synchronization with the power grid, the first electricity produced from nuclear power in Germany was fed into the interconnected grid system on June 17, 1961. In its 25 years of operation, VAK proved to be a valuable experimental facility. The plant was decommissioned on November 25, 1985 as planned. In order to maintain its experimental character also beyond the operating phase, the operators had agreed from the beginning to demolish VAK completely to green-field conditions immediately after the end of operations. This became official on May 17, 2010, when the plant was released from the scope of the Atomic Energy Act and was granted a permit for demolition under conventional building law. (orig.)

  13. Exploration of the inhibiting effect of Notch-1 blocker on tumor growth in osteosarcoma mouse models as well as related molecular mechanisms

    Institute of Scientific and Technical Information of China (English)

    Bin Zhou; Wei-Chun Guo

    2016-01-01

    Objective:To explore the inhibiting effect of Notch-1 blocker on tumor growth in osteosarcoma mouse models as well as related molecular mechanisms.Methods: SCID mice were selected as experimental subjects, and osteosarcoma mouse models were built through subcutaneous injection of osteosarcoma cells and divided into GSI group and PBS group who received GSI and PBS intervention respectively. 0 d, 5 d, 10 d, 15 d and 20 d after intervention, tumor tissue volume was detected; 20 d after intervention, the contents of pro-apoptosis, pro-proliferation and invasion-related molecules in tumor tissue were detected.Results: On the 0 d of intervention, tumor volume of GSI group was not significantly different from that of PBS group; 5 d, 10 d, 15 d and 20 d after intervention, tumor volume of GSI group was significantly lower than that of PBS group; 20 d after intervention, the contents of pro-proliferation molecules AEG-1, Orai1, STIM1, PAK5, RIPK4 andβ-catenin as well as invasion-promoting molecules Gab2, DLK1, Scr and B7-H3 in tumor tissue of GSI group were significantly lower than those of PBS group, and the contents of pro-apoptosis molecules RanBP9, PD-1, PD-L1 and PD-L2 as well as invasion-inhibiting molecules TIMP1 and TIMP2 were significantly higher than those of PBS group.Conclusion:Notch-1 blocker can inhibit tumor growth in osteosarcoma mouse models, and the molecular mechanisms involved in the process include reducing the generation of pro-proliferation molecules and invasion-promoting molecules and increasing the generation of pro-apoptosis and invasion-inhibiting molecules.

  14. Synthesis, molecular structure investigations and antimicrobial activity of 2-thioxothiazolidin-4-one derivatives

    Science.gov (United States)

    Barakat, Assem; Al-Najjar, Hany J.; Al-Majid, Abdullah Mohammed; Soliman, Saied M.; Mabkhot, Yahia Nasser; Al-Agamy, Mohamed H. M.; Ghabbour, Hazem A.; Fun, Hoong-Kun

    2015-02-01

    A variety of 2-thioxothiazolidin-4-one derivatives were prepared and their in vitro antimicrobial activities were studied. Most of these compounds showed significant antibacterial activity specifically against Gram-positive bacteria, among which compounds 4a,e,g, 5b,e,g,h and 6f exhibit high levels of antimicrobial activity against Bacillus subtilis ATCC 10400 with Minimum Inhibitory Concentration (MIC) value of 16 μg/mL. All compounds have antifungal activity against Candida albicans. Unfortunately, however, none of the compounds were active against Gram-negative bacteria. The chemical structure of 3 was confirmed by X-ray single crystal diffraction technique. DFT calculations of 3 have been performed on the free C10H7Cl2NO2S2, 3a and the H-bonded complex, C10H7Cl2NO2S2·H2O, 3b to explore the effect of the H-bonding interactions on the geometric and electronic properties of the studied systems. A small increase in bond length was observed in the C12-O6 due to the H-bonding interactions between 3a and water molecule. MEP study has been used to recognize the most reactive sites towards electrophilic and nucleophilic attacks as well as the possible sites for the H-bonding interactions. The TD-DFT calculations have been used to predict theoretically the electronic spectra of the studied compound. The most intense transition band is predicted at 283.9 nm due to the HOMO-2/HOMO-1 to LUMO transitions. NBO analyses were carried out to investigate the stabilization energy of the various intramolecular charge transfer interactions within the studied molecules.

  15. Risk factors of vagus nerve invasion in patients with advanced adenocarcinoma of esophagogastric junction%进展期食管胃结合部腺癌侵袭迷走神经的影响因素分析

    Institute of Scientific and Technical Information of China (English)

    孙敏志; 徐阿曼

    2013-01-01

    Objective To investigate the risk factors of vagus nerve invasion of advanced adenocarcinoma of esophagogastric junction (AEG).Methods The specimens from 98 patients with advanced AEG who underwent radical total gastrectomy and esophagogastric Roux-en-Y anastomosis from January 2011 to August 2012 at the First Affiliated Hospital of Anhui Medical University were collected.Serial section cutting was done and the upper and bottom incisional edges of every section were marked.The specimens were stained by hematoxylin-eosin solution,S-100 and CK immunohistochemistry.Vagus nerve invasion could be affirmed if cancer cells were observed in the peripheral space of vagus nerve and vagus nerve parenchyma or cancer cells infiltrated along the peripheral space of vagus nerve.Relationship between nerve invasion and clinicopathological factors was analyzed using chi-square test or Fisher exact probability.Factors related to vagus nerve invasion were analyzed using one-way analysis of variance and multi-factor logistic regression analysis.Results The incidence of vagus nerve invasion was 28.6% (28/98),and the tumor only invaded the vagus nerve which had the same altitude as the upper incisional edge.The results of one-way analysis of variance showed that Siewert classification,intravascular cancer emboli,lymph node metastasis,the degree of lymph node metastasis,clinical staging,the degree of tumor differentiation were correlated with the vagus nerve invasion (x2 =14.156,14.552,5.454,10.706,6.919,14.767,P < 0.05).The results of multi-factor logistic regression analysis showed that Siewert classification,intravascular cancer emboli and degree of tumor differentiation were the independent influencing factors of vague nerve invasion (OR =3.667,10.368,0.249,P < 0.05).Conclusion Vagus nerve invasion is correlated with Siewert classification,intravascular cancer emboli and degree of tumor differentiation.The range of vagus nerve invasion is restricted under the upper incisional

  16. Further observations on the utilization of adenosine triphosphate in rat mast cells during histamine release induced by the ionophore A23187

    DEFF Research Database (Denmark)

    Johansen, Torben

    1980-01-01

    1 The relation between A23187-induced histamine release and the energy metabolism of the rat mast cells has been studied. 2 Ethacrynic acid was used as an inhibitor of calcium-induced histamine release from mast cells primed with the ionophore A23187, and to study calcium-induced changes...... in the adenosine triphosphate (ATP) content and the rate of lactate production of A23187-primed mast cells. 3 Ethacrynic acid by itself decreased the rate of glycolytic ATP production. 4 By measurement of the ATP content and the lactate production of mast cells with or without secretory activity, the increased...... demand of energy for exocytosis was estimated to be equivalent to 0.14 pmol of ATP pr 10(3) mast cells....

  17. The Non-linear Saturation of the Goldreich-Schubert-Fricke Instability

    Science.gov (United States)

    Oishi, Jeffrey; Burns, Keaton; Brown, Ben; Lecoanet, Daniel; Vasil, Geoffrey

    2015-11-01

    The Goldreich-Schubert-Fricke (GSF) instability is an important process in stellar interiors and possibly in exoplanetary atmospheres. While the linear phase of the instability has been explored for nearly fifty years, its non-linear saturation has not been explored in detail. The GSF is a double-diffusive instability in which Rayleigh unstable perturbations are robbed of buoyant stability by thermal diffusion. Here, we will present results from a suite of direct numerical simulations using the Spiegel-Veronis Boussinesq equations in the Dedalus framework. These DNS are designed to explore the behavior of the GSF over a range of Prandtl numbers. In stellar interiors, Pr ~=10-6 , but we are limited by computational resources to much higher values, so instead we will discuss the Pr scaling of transport and mixing. We will also discuss the impact of the Boussinesq approximation in the case where large aspect ration perturbations exceed a scale height.

  18. Cutin monomer induces expression of the rice OsLTP5 lipid transfer protein gene.

    Science.gov (United States)

    Kim, Tae Hyun; Park, Jong Ho; Kim, Moon Chul; Cho, Sung Ho

    2008-01-01

    Treatment with the cutin monomer 16-hydroxypalmitic acid (HPA), a major component of cutin, elicited the synthesis of hydrogen peroxide (H2O2) in rice leaves and induced the expression of the lipid transfer protein gene OsLTP5. Treatment with HPA also induced expression of OsLTP1, OsLTP2, and the pathogen-related PR-10 genes to a lesser extent. The OsLTP5 transcript was expressed prominently in stems and flowers, but was barely detectable in leaves. Expression of OsLTP5 was induced in shoots in response to ABA and salicylic acid. It is proposed that HPA is perceived by rice as a signal, inducing defense reactions.

  19. Overexpression of GmERF5, a new member of the soybean EAR motif-containing ERF transcription factor, enhances resistance to Phytophthora sojae in soybean.

    Science.gov (United States)

    Dong, Lidong; Cheng, Yingxin; Wu, Junjiang; Cheng, Qun; Li, Wenbin; Fan, Sujie; Jiang, Liangyu; Xu, Zhaolong; Kong, Fanjiang; Zhang, Dayong; Xu, Pengfei; Zhang, Shuzhen

    2015-05-01

    Phytophthora root and stem rot of soybean [Glycine max (L.) Merr.], caused by Phytophthora sojae Kaufmann and Gerdemann, is a destructive disease throughout the soybean planting regions in the world. Here, we report insights into the function and underlying mechanisms of a novel ethylene response factor (ERF) in soybean, namely GmERF5, in host responses to P. sojae. GmERF5-overexpressing transgenic soybean exhibited significantly enhanced resistance to P. sojae and positively regulated the expression of the PR10, PR1-1, and PR10-1 genes. Sequence analysis suggested that GmERF5 contains an AP2/ERF domain of 58 aa and a conserved ERF-associated amphiphilic repression (EAR) motif in its C-terminal region. Following stress treatments, GmERF5 was significantly induced by P. sojae, ethylene (ET), abscisic acid (ABA), and salicylic acid (SA). The activity of the GmERF5 promoter (GmERF5P) was upregulated in tobacco leaves with ET, ABA, Phytophthora nicotianae, salt, and drought treatments, suggesting that GmERF5 could be involved not only in the induced defence response but also in the ABA-mediated pathway of salt and drought tolerance. GmERF5 could bind to the GCC-box element and act as a repressor of gene transcription. It was targeted to the nucleus when transiently expressed in Arabidopsis protoplasts. GmERF5 interacted with a basic helix-loop-helix transcription factor (GmbHLH) and eukaryotic translation initiation factor (GmEIF) both in yeast cells and in planta. To the best of our knowledge, GmERF5 is the first soybean EAR motif-containing ERF transcription factor demonstrated to be involved in the response to pathogen infection.

  20. 化疗对肺癌疼痛镇痛作用的临床评价%Clinical evaluation of analgesic efficacy of chemotherapy in 63 patients with lung cancer pain

    Institute of Scientific and Technical Information of China (English)

    丁永为

    2005-01-01

    目的评价化疗对肺癌疼痛的镇痛作用并探讨肺癌疼痛的治疗策略.方法 63例肺癌中度疼痛40例,重度疼痛23例.16例小细胞肺癌以CEP(CTX,Vp-16,DDP)或VMF-CP(Vp-16,MTX,5-Fu,CTX,DDP)方案化疗,47例非小细胞肺癌以NP(NVB,DDP)或CAP(CTX,ADM,DDP)方案化疗,并评价镇痛作用.结果疼痛完全缓解(CR)34例(54.0%),部分缓解(PR)27例(42.9%),无效2例,总疼痛缓解率96.8%.16例小细胞未分化癌疼痛缓解率100%,CR 11例(68.8%),PR 5例(31.2%);22例差分化癌疼痛缓解率100%,CR 12例(54.5%),PR 10例(45.5%);17例高分化鳞、腺癌疼痛缓解率94.1%,CR 6例(35.3%),PR 10例(58.8%),无效1例,不同分化程度肺癌疼痛CR率差异有显著性(χ2=4.0166,P0.05).结论化疗对缓解肺癌疼痛疗效显著,可作为肺癌疼痛的重要治疗措施.分化程度、疼痛部位和肿瘤客观疗效显著影响化疗镇痛效果.

  1. Alcohol reward is increased after Roux-en-Y gastric bypass in dietary obese rats with differential effects following ghrelin antagonism.

    Directory of Open Access Journals (Sweden)

    Andras Hajnal

    Full Text Available Roux-en-Y gastric bypass (RYGB is one of the most successful treatments for severe obesity and associated comorbidities. One potential adverse outcome, however, is increased risk for alcohol use. As such, we tested whether RYGB alters motivation to self-administer alcohol in outbred dietary obese rats, and investigated the involvement of the ghrelin system as a potential underlying mechanism. High fat (60%kcal from fat diet-induced obese, non-diabetic male Sprague Dawley rats underwent RYGB (n = 9 or sham operation (Sham, n = 9 and were tested 4 months after surgery on a progressive ratio-10 (PR10 schedule of reinforcement operant task for 2, 4, and 8% ethanol. In addition, the effects of the ghrelin-1a-receptor antagonist D-[Lys3]-GHRP-6 (50, 100 nmol/kg, IP were tested on PR10 responding for 4% ethanol. Compared to Sham, RYGB rats made significantly more active spout responses to earn reward, more consummatory licks on the ethanol spout, and achieved higher breakpoints. Pretreatment with a single peripheral injection of D-[Lys3]-GHRP-6 at either dose was ineffective in altering appetitive or consummatory responses to 4% ethanol in the Sham group. In contrast, RYGB rats demonstrated reduced operant performance to earn alcohol reward on the test day and reduced consummatory responses for two subsequent days following the drug. Sensitivity to threshold doses of D-[LYS3]-GHRP-6 suggests that an augmented ghrelin system may contribute to increased alcohol reward in RYGB. Further research is warranted to confirm applicability of these findings to humans and to explore ghrelin-receptor targets for treatment of alcohol-related disorders in RYGB patients.

  2. Enlarging the toolbox for allergen epitope definition with an allergen-type model protein.

    Directory of Open Access Journals (Sweden)

    Hanna Berkner

    Full Text Available Birch pollen-allergic subjects produce polyclonal cross-reactive IgE antibodies that mediate pollen-associated food allergies. The major allergen Bet v 1 and its homologs in plant foods bind IgE in their native protein conformation. Information on location, number and clinical relevance of IgE epitopes is limited. We addressed the use of an allergen-related protein model to identify amino acids critical for IgE binding of PR-10 allergens.Norcoclaurine synthase (NCS from meadow rue is structurally homologous to Bet v 1 but does not bind Bet v 1-reactive IgE. NCS was used as the template for epitope grafting. NCS variants were tested with sera from 70 birch pollen allergic subjects and with monoclonal antibody BV16 reported to compete with IgE binding to Bet v 1.We generated an NCS variant (Δ29NCSN57/I58E/D60N/V63P/D68K harboring an IgE epitope of Bet v 1. Bet v 1-type protein folding of the NCS variant was evaluated by 1H-15N-HSQC NMR spectroscopy. BV16 bound the NCS variant and 71% (50/70 sera of our study population showed significant IgE binding. We observed IgE and BV16 cross-reactivity to the epitope presented by the NCS variant in a subgroup of Bet v 1-related allergens. Moreover BV16 blocked IgE binding to the NCS variant. Antibody cross-reactivity depended on a defined orientation of amino acids within the Bet v 1-type conformation.Our system allows the evaluation of patient-specific epitope profiles and will facilitate both the identification of clinically relevant epitopes as biomarkers and the monitoring of therapeutic outcomes to improve diagnosis, prognosis, and therapy of allergies caused by PR-10 proteins.

  3. Characterization of Withania somnifera leaf transcriptome and expression analysis of pathogenesis-related genes during salicylic acid signaling.

    Directory of Open Access Journals (Sweden)

    Modhumita Ghosh Dasgupta

    Full Text Available Withania somnifera (L. Dunal is a valued medicinal plant with pharmaceutical applications. The present study was undertaken to analyze the salicylic acid induced leaf transcriptome of W. somnifera. A total of 45.6 million reads were generated and the de novo assembly yielded 73,523 transcript contig with average transcript contig length of 1620 bp. A total of 71,062 transcripts were annotated and 53,424 of them were assigned GO terms. Mapping of transcript contigs to biological pathways revealed presence of 182 pathways. Seventeen genes representing 12 pathogenesis-related (PR families were mined from the transcriptome data and their pattern of expression post 17 and 36 hours of salicylic acid treatment was documented. The analysis revealed significant up-regulation of all families of PR genes by 36 hours post treatment except WsPR10. The relative fold expression of transcripts ranged from 1 fold to 6,532 fold. The two families of peroxidases including the lignin-forming anionic peroxidase (WsL-PRX and suberization-associated anionic peroxidase (WsS-PRX recorded maximum expression of 377 fold and 6532 fold respectively, while the expression of WsPR10 was down-regulated by 14 fold. Additionally, the most stable reference gene for normalization of qRT-PCR data was also identified. The effect of SA on the accumulation of major secondary metabolites of W. somnifera including withanoside V, withaferin A and withanolide A was also analyzed and an increase in content of all the three metabolites were detected. This is the first report on expression patterns of PR genes during salicylic acid signaling in W. somnifera.

  4. Characterization of Withania somnifera leaf transcriptome and expression analysis of pathogenesis-related genes during salicylic acid signaling.

    Science.gov (United States)

    Ghosh Dasgupta, Modhumita; George, Blessan Santhosh; Bhatia, Anil; Sidhu, Om Prakash

    2014-01-01

    Withania somnifera (L.) Dunal is a valued medicinal plant with pharmaceutical applications. The present study was undertaken to analyze the salicylic acid induced leaf transcriptome of W. somnifera. A total of 45.6 million reads were generated and the de novo assembly yielded 73,523 transcript contig with average transcript contig length of 1620 bp. A total of 71,062 transcripts were annotated and 53,424 of them were assigned GO terms. Mapping of transcript contigs to biological pathways revealed presence of 182 pathways. Seventeen genes representing 12 pathogenesis-related (PR) families were mined from the transcriptome data and their pattern of expression post 17 and 36 hours of salicylic acid treatment was documented. The analysis revealed significant up-regulation of all families of PR genes by 36 hours post treatment except WsPR10. The relative fold expression of transcripts ranged from 1 fold to 6,532 fold. The two families of peroxidases including the lignin-forming anionic peroxidase (WsL-PRX) and suberization-associated anionic peroxidase (WsS-PRX) recorded maximum expression of 377 fold and 6532 fold respectively, while the expression of WsPR10 was down-regulated by 14 fold. Additionally, the most stable reference gene for normalization of qRT-PCR data was also identified. The effect of SA on the accumulation of major secondary metabolites of W. somnifera including withanoside V, withaferin A and withanolide A was also analyzed and an increase in content of all the three metabolites were detected. This is the first report on expression patterns of PR genes during salicylic acid signaling in W. somnifera.

  5. International Association for Promoting Geoethics (IAPG): an update on activities

    Science.gov (United States)

    Di Capua, Giuseppe; Bobrowsky, Peter; Kieffer, Susan; Peppoloni, Silvia; Tinti, Stefano

    2016-04-01

    The International Association for Promoting Geoethics (IAPG: http://www.geoethics.org) was founded on August 2012 to unite global geoscientists to raise the awareness of the scientific community regarding the importance of the ethical, social and cultural implications of geoscience research, education, and practice. IAPG is an international, multidisciplinary and scientific platform for discussion on ethical problems and dilemmas in Earth Sciences, promoting geoethical themes through scientific publications and conferences, strengthening the research base on geoethics, and focusing on case-studies as models for the development of effective and operative strategies. IAPG is legally recognized as a not-for-profit organization. It is a non-governmental, non-political, non-party institution, at all times free from racial, gender, religious or national prejudices. Its network continues to grow with more than 900 members in 103 countries, including 20 national sections. IAPG operates exclusively through donations and personal funds of its members. The results achieved since inception have been recognized by numerous international organizations. In particular, IAPG has obtained the status of affiliated organization by the International Union of Geological Sciences (IUGS), American Geosciences Institute (AGI), Geological Society of America (GSA), and the Geological Society of London (GSL). IAPG has enlarged its official relationships also through agreements on collaboration with other organizations, such as the American Geophysical Union (AGU), EuroGeoSurveys (EGS), European Federation of Geologists (EFG), Association of Environmental & Engineering Geologists (AEG), International Geoscience Education Organisation (IGEO), African Association of Women in Geosciences (AAWG), and others. IAPG considers publications as an indispensable activity to strengthen geoethics from a scientific point of view, so members are active in the publication of articles and editing of books on

  6. Noor-Eestile : [luuletused] / Juhan Liiv ; [Impressioonid]: Viiu Härm

    Index Scriptorium Estoniae

    Liiv, Juhan, 1864-1913

    2004-01-01

    Sisu: Noor-Eestile ; Vask oli taevas mu üle ; Andke vaesel' eksijale varju ; Palju on must üle käinud ; Ma kõndisin metsa poole ; Minu saatus ; Tule, öö pimedus ; Helin ; Mets kohas ; Minu luule ; Ma pimeduses olen laulnud ; Naised kangast seadvad ; Öösse ära kadus ; Mure II ; Masinlikult liigub mõte ; Tuelvik ; Kui tume veel kauaks ka sinu maa ; Mitte igaühele ; Mis meil kaunis, mis meil kallis ; Meri ; Ta lendab mesipuu poole ; Ma lille sideme võtaks ; Kõik kohad täis ; Sa oled püha ja ilus ; Kadumatu ; Isamaale ; Must lagi on meie toal ; Laul sellest kaduvast ; Eile nägin ma Eestimaad! ; Kas ma Eestit unes nägin? ; Siin väsimatu olgu julgus ; Mina ei tea, kust ma rõõmu võtan? ; Minu erakond ; Üks suu ; Noorusaeg ; Naerata! ; Ei sinu ilust ; Oleksin ma luuletaja! ; Neiule ; Üle vee ; Sügise päikene ; Ei sinu iludus ; Sa tulid ; Sina ja mina ; Mai hommik ; Mu viimane laul ; Arm tuli ; Mis on kui vaikne valu hääl? ; Tuuled, te juurde ma tulen ; Ei valust me enam räägi ; Tulen, tulen! ; Üks märtsihommik udune ; Kevade lähenemine ; Noor kevade ; Tuli kevade ; Meelespea ; Järv ; Suine tuul ; Üks suve päev ; Sügisene kodu ; Tühja pesa ees ; Sööt ; Oh kanarbik, oh lilleke! ; Vanaema sügise ; Sügise ; Sügise päike ; Nõmm ; Üksik tee ; Tuul rabistab lehti maha ; Pilved sõudvad ; Sügise tuul ; Mets ; Sügisene rand ; Lume helbeke ; Tali ; Talve õhtul ; Ma vaatan aknast välja ; Lauliku talve üksindus ; Rukkivihud rehe all ; Talvine tihane ; Tuisk ; Lained, kuhu te tõttate? ; Ema ja tütar ; Rändaja ; Muusika ; Meeled ; Aeg ; Vali on ; Mis isad ütlevad ; Koer ; Kes meeldida tahab ; Mul kannatlik, hää süda on ; Me igapäev paremat loodame ; Üks mälestus ; Sa oled hää ja puhas ; Hõlpsam on mägesid tõsta ; Omakasu ; Laulikutele ; Killud ; Viimane võimalus

  7. Identifying Patient-Specific Epstein-Barr Nuclear Antigen-1 Genetic Variation and Potential Autoreactive Targets Relevant to Multiple Sclerosis Pathogenesis.

    Directory of Open Access Journals (Sweden)

    Monika Tschochner

    Full Text Available Epstein-Barr virus (EBV infection represents a major environmental risk factor for multiple sclerosis (MS, with evidence of selective expansion of Epstein-Barr Nuclear Antigen-1 (EBNA1-specific CD4+ T cells that cross-recognize MS-associated myelin antigens in MS patients. HLA-DRB1*15-restricted antigen presentation also appears to determine susceptibility given its role as a dominant risk allele. In this study, we have utilised standard and next-generation sequencing techniques to investigate EBNA-1 sequence variation and its relationship to HLA-DR15 binding affinity, as well as examining potential cross-reactive immune targets within the central nervous system proteome.Sanger sequencing was performed on DNA isolated from peripheral blood samples from 73 Western Australian MS cases, without requirement for primary culture, with additional FLX 454 Roche sequencing in 23 samples to identify low-frequency variants. Patient-derived viral sequences were used to predict HLA-DRB1*1501 epitopes (NetMHCII, NetMHCIIpan and candidates were evaluated for cross recognition with human brain proteins.EBNA-1 sequence variation was limited, with no evidence of multiple viral strains and only low levels of variation identified by FLX technology (8.3% nucleotide positions at a 1% cut-off. In silico epitope mapping revealed two known HLA-DRB1*1501-restricted epitopes ('AEG': aa 481-496 and 'MVF': aa 562-577, and two putative epitopes between positions 502-543. We identified potential cross-reactive targets involving a number of major myelin antigens including experimentally confirmed HLA-DRB1*15-restricted epitopes as well as novel candidate antigens within myelin and paranodal assembly proteins that may be relevant to MS pathogenesis.This study demonstrates the feasibility of obtaining autologous EBNA-1 sequences directly from buffy coat samples, and confirms divergence of these sequences from standard laboratory strains. This approach has identified a number of

  8. Ginsenoside Rg1 prevents cognitive impairment and hippocampus senescence in a rat model of D-galactose-induced aging.

    Directory of Open Access Journals (Sweden)

    Jiahong Zhu

    Full Text Available Neurogenesis continues throughout the lifetime in the hippocampus, while the rate declines with brain aging. It has been hypothesized that reduced neurogenesis may contribute to age-related cognitive impairment. Ginsenoside Rg1 is an active ingredient of Panax ginseng in traditional Chinese medicine, which exerts anti-oxidative and anti-aging effects. This study explores the neuroprotective effect of ginsenoside Rg1 on the hippocampus of the D-gal (D-galactose induced aging rat model. Sub-acute aging was induced in male SD rats by subcutaneous injection of D-gal (120 mg/kg·d for 42 days, and the rats were treated with ginsenoside Rg1 (20 mg/kg·d, intraperitoneally or normal saline for 28 days after 14 days of D-gal injection. In another group, normal male SD rats were treated with ginsenoside Rg1 alone (20 mg/kg·d, intraperitoneally for 28 days. It showed that administration of ginsenoside Rg1 significantly attenuated all the D-gal-induced changes in the hippocampus, including cognitive capacity, senescence-related markers and hippocampal neurogenesis, compared with the D-gal-treated rats. Further investigation showed that ginsenoside Rg1 protected NSCs/NPCs (neural stem cells/progenitor cells shown by increased level of SOX-2 expression; reduced astrocytes activation shown by decrease level of Aeg-1 expression; increased the hippocampal cell proliferation; enhanced the activity of the antioxidant enzymes GSH-Px (glutathione peroxidase and SOD (Superoxide Dismutase; decreased the levels of IL-1β, IL-6 and TNF-α, which are the proinflammatory cytokines; increased the telomere lengths and telomerase activity; and down-regulated the mRNA expression of cellular senescence associated genes p53, p21Cip1/Waf1 and p19Arf in the hippocampus of aged rats. Our data provides evidence that ginsenoside Rg1 can improve cognitive ability, protect NSCs/NPCs and promote neurogenesis by enhancing the antioxidant and anti-inflammatory capacity in the

  9. Dielectric breakdown of cell membranes.

    Science.gov (United States)

    Zimmermann, U; Pilwat, G; Riemann, F

    1974-11-01

    With human and bovine red blood cells and Escherichia coli B, dielectric breakdown of cell membranes could be demonstrated using a Coulter Counter (AEG-Telefunken, Ulm, West Germany) with a hydrodynamic focusing orifice. In making measurements of the size distributions of red blood cells and bacteria versus increasing electric field strength and plotting the pulse heights versus the electric field strength, a sharp bend in the otherwise linear curve is observed due to the dielectric breakdown of the membranes. Solution of Laplace's equation for the electric field generated yields a value of about 1.6 V for the membrane potential at which dielectric breakdown occurs with modal volumes of red blood cells and bacteria. The same value is also calculated for red blood cells by applying the capacitor spring model of Crowley (1973. Biophys. J. 13:711). The corresponding electric field strength generated in the membrane at breakdown is of the order of 4 . 10(6) V/cm and, therefore, comparable with the breakdown voltages for bilayers of most oils. The critical detector voltage for breakdown depends on the volume of the cells. The volume-dependence predicted by Laplace theory with the assumption that the potential generated across the membrane is independent of volume, could be verified experimentally. Due to dielectric breakdown the red blood cells lose hemoglobin completely. This phenomenon was used to study dielectric breakdown of red blood cells in a homogeneous electric field between two flat platinum electrodes. The electric field was applied by discharging a high voltage storage capacitor via a spark gap. The calculated value of the membrane potential generated to produce dielectric breakdown in the homogeneous field is of the same order as found by means of the Coulter Counter. This indicates that mechanical rupture of the red blood cells by the hydrodynamic forces in the orifice of the Coulter Counter could also be excluded as a hemolysing mechanism. The detector

  10. Lasteaia ja lõbumaja vahel : eesti proosa 2008 / Vaapo Vaher

    Index Scriptorium Estoniae

    Vaher, Vaapo, 1945-

    2009-01-01

    Ülevaade 2008. aasta eesti proosast. Pikemalt käsitletakse järgmisi autoreid ja nende teoseid: Mihkel Raud "Musta pori näkku", Olev Remsu "Musketäride muundumised", Rein Põder "Juba olnud", Juhan Nurme "Ligimene", Jaan Tangsoo "Méduse'i parv", Esta Aksli "Tare poole tõttaja", Mari Saat "Lasnamäe lunastaja", Peeter Morgen "Sõnum", Mait Raun "Dr. Mööbi seiklused Inglismaal", Andrei Hvostov "Võõrad lood" ja "Projektijuht Posse", Chaneldior "Kontrolli alt väljas", Vahur Afanasjev "Kosmos", Egon Ilisson "Isased", Jaak Leer "Kaks kabanossi ja Maaja", Kärt Hellerma "Sinine missa", Elo Viiding "Püha Maama", Toomas Raudam "Miks ma ei taha olla kirjanik?", Mart Kivastik "Kurb raamat", Jüri Tuulik "Räim, pisike kena kala", Tarmo Teder "12 jõulujuttu", Dagmar Lamp (koostaja) "Tule, ma jutustan sulle loo", Eia Uus "Kahe näoga jumal", Barthol Lo Mejor "Popdada 2007-2008", Anti Saar "Nemad kaks", Ketlin Priilinn "Liiseli võti" ja "Vaim", Aita Kivi "Lähedal", Marje Ernits "Hoia mu kätt", Kati Murutar "Naisena sündinud : kakskümmend aastat hiljem", Tuule Lind "Pööratud tuul", Siiri Laidla "Lihtne lugu, ehk, Senta suvepuhkus", Kätlin Padesaar "Veel üks paradiis", Aimée Beekman "Proovielu", Lehte Hainslau "Kolmkõla, ehk, 3 kõla", Ira Lember "Ööviiulid", Tamur Kusnets "Hundipäikese aeg : metsiku jahi algus", Kaupo Pähkel "Ehatähe rüütel", Arvo Valton "Ülemiste vanake", Tiit Aleksejev "Palveränd", Ants Eret "Afgaanide vang", Mario Merirand "Afganistani päevik", Leo Kunnas "Gort Ashryn", Rein Raud "Vend", Peeter Sauter "Beibi bluu", Marion Andra "Pimend", Kristjan Sander "13 talvist hetke", Helga Nõu "Peaaegu geenius, ehk, Schrödingeri kassi otsimas", Tiit Sepa "Eefa hüüdnimega Siug", Kaarel ja Klaara Kivi "Varandus seinal", Merike Jürjo "Mälestusteta maja", Rein Vahisalu "Viies kabinet", Aarne Biin "Mees otsib naist", Erik Tohvri "Ümberasujad" ja "Sulasest sai peremees", Arnold Laugus "Elav maa", Jüri v. Grauberg "Selguse poole", J

  11. Lasteaia ja lõbumaja vahel : Eesti proosa 2008 / Vaapo Vaher

    Index Scriptorium Estoniae

    Vaher, Vaapo, 1945-

    2012-01-01

    Ülevaade 2008. aasta eesti proosast. Pikemalt käsitletakse järgmisi autoreid ja nende teoseid: Mihkel Raud "Musta pori näkku", Olev Remsu "Musketäride muundumised", Rein Põder "Juba olnud", Juhan Nurme "Ligimene", Jaan Tangsoo "Méduse'i parv", Esta Aksli "Tare poole tõttaja", Mari Saat "Lasnamäe lunastaja", Peeter Morgen "Sõnum", Mait Raun "Dr. Mööbi seiklused Inglismaal", Andrei Hvostov "Võõrad lood" ja "Projektijuht Posse", Chaneldior "Kontrolli alt väljas", Vahur Afanasjev "Kosmos", Egon Ilisson "Isased", Jaak Leer "Kaks kabanossi ja Maaja", Kärt Hellerma "Sinine missa", Elo Viiding "Püha Maama", Toomas Raudam "Miks ma ei taha olla kirjanik?", Mart Kivastik "Kurb raamat", Jüri Tuulik "Räim, pisike kena kala", Tarmo Teder "12 jõulujuttu", Dagmar Lamp (koostaja) "Tule, ma jutustan sulle loo", Eia Uus "Kahe näoga jumal", Barthol Lo Mejor "Popdada 2007-2008", Anti Saar "Nemad kaks", Ketlin Priilinn "Liiseli võti" ja "Vaim", Aita Kivi "Lähedal", Marje Ernits "Hoia mu kätt", Kati Murutar "Naisena sündinud : kakskümmend aastat hiljem", Tuule Lind "Pööratud tuul", Siiri Laidla "Lihtne lugu, ehk, Senta suvepuhkus", Kätlin Padesaar "Veel üks paradiis", Aimée Beekman "Proovielu", Lehte Hainslau "Kolmkõla, ehk, 3 kõla", Ira Lember "Ööviiulid", Tamur Kusnets "Hundipäikese aeg : metsiku jahi algus", Kaupo Pähkel "Ehatähe rüütel", Arvo Valton "Ülemiste vanake", Tiit Aleksejev "Palveränd", Ants Eret "Afgaanide vang", Mario Merirand "Afganistani päevik", Leo Kunnas "Gort Ashryn", Rein Raud "Vend", Peeter Sauter "Beibi bluu", Marion Andra "Pimend", Kristjan Sander "13 talvist hetke", Helga Nõu "Peaaegu geenius, ehk, Schrödingeri kassi otsimas", Tiit Sepa "Eefa hüüdnimega Siug", Kaarel ja Klaara Kivi "Varandus seinal", Merike Jürjo "Mälestusteta maja", Rein Vahisalu "Viies kabinet", Aarne Biin "Mees otsib naist", Erik Tohvri "Ümberasujad" ja "Sulasest sai peremees", Arnold Laugus "Elav maa", Jüri v. Grauberg "Selguse poole", J

  12. 111例胃癌和胃食管结合部癌合并恶性胸腹腔积液患者的预后分析%Analysis of the prognosis of 111 patients with gastric cancer or adenocarcinoma of the esophagogastric junction combined with pleural or abdominal effusion

    Institute of Scientific and Technical Information of China (English)

    刘毅; 杜春霞; 张弘纲

    2013-01-01

    Objective To explore the prognostic factors in patients with gastric cancer (GC) or adenocarcinoma of the esophagogastric junction (AEG) combined with malignant pleural and/or abdominal effusion.Methods Clinicopathological data of 111 GC or AEG patients with malignant pleural and/or abdominal effusion treated in our hospital from January 2001 to December 2010 were retrospectively analyzed.Results The median survival time for the whole group of 111 patients was 6 months.Effusion disappeared in 12 patients,was reduced in 36 cases,with no changes in 15 cases,and increased in 48 patients.The effusion control rate was 56.8%.Effusion was better controlled in female patients,with simple abdominal ascites,Karnovsky performance scores ≥ 80,with no liver metastases,effusion at initial diagnosis,and effective response to systemic chemotherapy.Univariate analysis showed that patients of female sex,Karnovsky performance scores ≥ 80,effusion present at initial diagnosis,simple abdominal ascites,minimal volume of effusion,absence of liver metastasis,control of effusion,initial treatment with effusions and effective response to systemic chemotherapy,normal hemoglobin,albumin,direct and indirect bilirubin levels showed better prognosis (all P < 0.05).Multivariate analysis showed that liver metastases,control of effusions were independent prognostic factors in patients with gastric cancer and adenocarcinoma of the esophagogastric junction (all P < 0.05).Conclusions Female patients,simple abdominal ascites,KPS scores ≥80,ascites at initial diagnosis,no liver metastases and effective systemic chemotherapy seem to have a better control of the malignant effusion.Patients with no liver metastases and effective control of effusion have a longer survival time.%目的 分析胃癌和胃食管结合部癌合并恶性胸腹腔积液患者的预后,并探讨其影响因素.方法 回顾性分析2001年1月至2010年12月中国医学科学院肿瘤医院收治的111例胃癌和胃

  13. Recém-nascido pequeno para a idade gestacional: repercussão nas habilidades motoras finas Pequeño para la edad gestacional: repercusión en las habilidades motoras finas Small-for-gestational-age newborn infant: repercussion on fine motor skills

    Directory of Open Access Journals (Sweden)

    Amabile Vessoni Arias

    2011-03-01

    Full Text Available OBJETIVO: Comparar as habilidades motoras finas de lactentes nascidos a termo pequenos para a idade gestacional (PIG com as habilidades dos nascidos adequados para a idade gestacional (AIG no terceiro mês de vida. MÉTODOS: Realizou-se um estudo observacional de corte transversal. Avaliaram-se 67 lactentes (21 PIG e 46 AIG no terceiro mês de vida. Portadores de síndromes genéticas, malformações congênitas, infecções congênitas e aqueles que necessitaram de unidade de terapia intensiva neonatal foram excluídos. As Escalas Bayley II de Desenvolvimento Infantil foram utilizadas, com ênfase nos itens que avaliam as habilidades motoras finas. RESULTADOS: Não se observaram diferenças entre os grupos na escala motora (p=0,21 e mental (p=0,45 no terceiro mês de vida. No item "Alcança o Aro Suspenso", houve diferença significativa (teste Exato de Fisher; p=0,02, demonstrando maior frequência de execução para o grupo PIG no terceiro mês de vida. CONCLUSÕES: Supõe-se que a diferença encontrada no item "Alcança o Aro Suspenso" possa ser atribuída à grande ocorrência de movimentos dos braços observada no grupo PIG e não a uma condição melhor de desenvolvimento desse grupo.OBJETIVO: Comparar las habilidades motoras finas de lactantes nacidos a término pequeños para la edad gestacional (PEG con adecuados para la edad gestacional (AEG en el 3er mes de vida. MÉTODOS: Se realizó un estudio observacional de corte transversal. Se evaluaron a 67 lactantes (21 PEG y 46 AEG en el 3er mes de vida. Síndromes genéticos, malformaciones congénitas, infecciones congénitas y aquellos que necesitaron de unidad de terapia intensiva neonatal fueron excluidos. Las Escalas Bayley II y de Desarrollo Infantil fueron utilizadas, con énfasis en los ítems que evalúan las habilidades motoras finas. RESULTADOS: No se observaron diferencias entre los grupos en la escala motora (p=0,21 y mental (p=0,45 en el 3er mes de vida. En el ítem "alcanza

  14. Tumor response and clinical outcome in metastatic gastrointestinal stromal tumors under sunitinib therapy: Comparison of RECIST, Choi and volumetric criteria

    Energy Technology Data Exchange (ETDEWEB)

    Schramm, N., E-mail: Nicolai.schramm@med.uni-muenchen.de [Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany); Englhart, E., E-mail: Elisabeth.Englhart@gmx.de [Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany); Schlemmer, M., E-mail: Marcus.Schlemmer@med.uni-muenchen.de [Department of Medicine III, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany); Hittinger, M., E-mail: Markus.Hittinger@uksh.de [Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany); Übleis, C., E-mail: Christopher.Uebleis@med.uni-muenchen.de [Department of Nuclear Medicine, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany); Becker, C.R., E-mail: Christoph.becker@med.uni-muenchen.de [Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany); Reiser, M.F., E-mail: Maximilian.Reiser@med.uni-muenchen.de [Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany); Berger, F., E-mail: Frank.Berger@med.uni-muenchen.de [Institute for Clinical Radiology, Ludwig-Maximilians-University Hospital Munich, Marchioninistrasse 15, 81377 Munich (Germany)

    2013-06-15

    Purpose: Purpose of the study was to compare radiological treatment response according to RECIST, Choi and volumetry in GIST-patients under 2nd-line-sunitinib-therapy and to correlate the results of treatment response assessment with disease-specific survival (DSS). Patients and methods: 20 patients (mean: 60.7 years; 12 male/8 female) with histologically proven GIST underwent baseline-CT of the abdomen under imatinib and follow-up-CTs 3 months and 1 year after change to sunitinib. 68 target lesions (50 hepatic, 18 extrahepatic) were investigated. Therapy response (partial response (PR), stable disease (SD), progressive disease (PD)) was evaluated according to RECIST, Choi and volumetric criteria. Response according to the different assessment systems was compared and correlated to the DSS of the patients utilizing Kaplan–Meier statistics. Results: The mean DSS (in months) of the response groups 3 months after therapy change was: RECIST: PR (0/20); SD (17/20): 30.4 (months); PD (3/20) 11.6. Choi: PR (10/20) 28.6; SD (8/20) 28.1; PD (2/20) 13.5. Volumetry: PR (4/20) 29.6; SD (11/20) 29.7; PD (5/20) 17.2. Response groups after 1 year of sunitinib showed the following mean DSS: RECIST: PR (3/20) 33.6; SD (9/20) 29.7; PD (8/20) 20.3. Choi: PR (10/20) 21.5; SD (4/20) 42.9; PD (6/20) 23.9. Volumetry: PR (6/20) 27.3; SD (5/20) 38.5; PD (9/20) 19.3. Conclusion: One year after modification of therapy, only partial response according to RECIST indicated favorable survival in patients with GIST. The value of alternate response assessment strategies like Choi criteria for prediction of survival in molecular therapy still has to be demonstrated.

  15. The Short Series of the Oxygen-Poor Lanthanide Oxide Selenides M10OSe14 with M = La–Nd

    Directory of Open Access Journals (Sweden)

    Frank A. Weber

    2012-08-01

    Full Text Available Single crystals and phase pure samples of oxygen-poor ternary lanthanide oxide selenides with the composition M10OSe14 (M = La–Nd; tetragonal, I41/acd; a = 1592.0–1559.8 pm, c = 2106.5–2062.9 pm could be obtained by reacting the corresponding metals, selenium and selenium dioxide as oxygen source. Their crystal structures are isotypic with Pr10OS14 and thus contain isolated [OM4]10+ tetrahedra (d(O2––M3+ = 243–248 pm embedded in a complex anionic {[M6Se14]10–} lanthanide selenide matrix (d(M3+–Se2– = 288–358 pm. All three crystallographically independent M3+ cations exhibit eight contacts to chalcogenide anions (O2– and/or Se2– resulting in the formation of bicapped trigonal prismatic coordination polyhedra. The optical band gaps of the oxide selenides M10OSe14 amount to values between 1.89 and 2.04 eV indicating wide band-gap semiconductors.

  16. [A case of anaphylaxis due to rose-flavored soft-serve ice cream with pollen food allergy syndrome].

    Science.gov (United States)

    Kitabayashi, Taeru; Sato, Sayuri; Adachi, Mitsuru

    2013-05-01

    We experienced a 10-year-old boy who had anaphylaxis after eating rose-flavored soft-serve ice cream. The patient felt a sense of discomfort in his throat when eating apple, peach, loquat, Japanese pear, and kiwi fruit. Therefore, we measured specific IgE antibodies to allergen components by ImmunoCAP ISAC. Consequently, the patient gave positive results for all PR-10 proteins from birch, alder, hazel, apple, peach, peanut, hazelnut, and soybean, so we diagnosed him with Pollen Food Allergy Syndrome (PFAS) induced by cross reactivity with pollens of birch family and fruits of rose family. When we conducted the skin prick test as is for red rose syrup because of the belief that anaphylaxis was caused by the rose ingredient contained in rose-flavored soft-serve ice cream, the patient gave a strong positive result. However, the results were negative for rose essence and Food Red No. 2 contained. Subsequently, it was found that red rose syrup contained apple juice. Therefore, we conducted the prick-prick test for apple, and the patient was confirmed to be strongly positive to apple. We thus identified apple as the cause of anaphylaxis. Since there is no legal obligation of labeling specific raw materials when directly selling manufactured and processed food products to general consumers, it is possible for general consumers to mistakenly take them in without knowing the containment of allergic substances. It is believed that the labeling method should be improved in the future.

  17. Transcriptome Analysis of Early Responsive Genes in Rice during Magnaporthe oryzae Infection

    Directory of Open Access Journals (Sweden)

    Yiming Wang

    2014-12-01

    Full Text Available Rice blast disease caused by Magnaporthe oryzae is one of the most serious diseases of cultivated rice (Oryza sativa L. in most rice-growing regions of the world. In order to investigate early response genes in rice, we utilized the transcriptome analysis approach using a 300 K tilling microarray to rice leaves infected with compatible and incompatible M. oryzae strains. Prior to the microarray experiment, total RNA was validated by measuring the differential expression of rice defense-related marker genes (chitinase 2, barwin, PBZ1, and PR-10 by RT-PCR, and phytoalexins (sakuranetin and momilactone A with HPLC. Microarray analysis revealed that 231 genes were up-regulated (>2 fold change, p < 0.05 in the incompatible interaction compared to the compatible one. Highly expressed genes were functionally characterized into metabolic processes and oxidation-reduction categories. The oxidative stress response was induced in both early and later infection stages. Biotic stress overview from MapMan analysis revealed that the phytohormone ethylene as well as signaling molecules jasmonic acid and salicylic acid is important for defense gene regulation. WRKY and Myb transcription factors were also involved in signal transduction processes. Additionally, receptor-like kinases were more likely associated with the defense response, and their expression patterns were validated by RT-PCR. Our results suggest that candidate genes, including receptor-like protein kinases, may play a key role in disease resistance against M. oryzae attack.

  18. Elevated ozone alters soybean-virus interaction.

    Science.gov (United States)

    Bilgin, Damla D; Aldea, Mihai; O'Neill, Bridget F; Benitez, Marisol; Li, Min; Clough, Steven J; DeLucia, Evan H

    2008-10-01

    Increasing concentrations of ozone (O(3)) in the troposphere affect many organisms and their interactions with each other. To analyze the changes in a plant-pathogen interaction, soybean plants were infected with Soybean mosaic virus (SMV) while they were fumigated with O(3). In otherwise natural field conditions, elevated O(3) treatment slowed systemic infection and disease development by inducing a nonspecific resistance against SMV for a period of 3 weeks. During this period, the negative effect of virus infection on light-saturated carbon assimilation rate was prevented by elevated O(3) exposure. To identify the molecular basis of a soybean nonspecific defense response, high-throughput gene expression analysis was performed in a controlled environment. Transcripts of fungal, bacterial, and viral defense-related genes, including PR-1, PR-5, PR-10, and EDS1, as well as genes of the flavonoid biosynthesis pathways (and concentrations of their end products, quercetin and kaempherol derivatives) increased in response to elevated O(3). The drastic changes in soybean basal defense response under altered atmospheric conditions suggest that one of the elements of global change may alter the ecological consequences and, eventually, coevolutionary relationship of plant-pathogen interactions in the future.

  19. Personal and behavioral factors associated with bicycling in adults from Curitiba, Parana State, Brazil

    Directory of Open Access Journals (Sweden)

    Marilson Kienteka

    2014-01-01

    Full Text Available Bicycling is an important form of physical activity that can promote health benefits. The objective of this study was to analyze the association between personal and behavioral aspects in transportation bicycling and leisure time bicycling in adults. Data was drawn from a household survey involving 677 adults (53.1% female in Curitiba, Paraná State, Brazil. The prevalence of bicycling was 11.2% for transportation and 16.7% for leisure. The frequency of leisure time bicycling was higher among men (PR = 2.08; p < 0.001, young people < 30 and adults aged between 30 and 39.9, bicycle owners (PR = 8.76; p < 0.001 and among the physically active. Transportation bicycling occurred more frequently among men (PR = 3.63; p < 0.001, individuals aged 30 to 39.9, those with a low socioeconomic status (PR = 5.00; p = 0.006, bicycle owners (PR = 10.2; p < 0.001 and individuals with a negative perception of their quality of life. The prevalence of bicycling is low in Curitiba considering its potential as a means of physical activity. Personal and behavioral factors were associated with each form of bicycling.

  20. Prevalence, risk factors and social context of active pulmonary tuberculosis among prison inmates in Tajikistan.

    Directory of Open Access Journals (Sweden)

    Daniel E Winetsky

    Full Text Available SETTING: Tuberculosis (TB is highly prevalent in prisons of the former Soviet Union. OBJECTIVE: To understand the behavioral, demographic and biological factors placing inmates in Tajikistan at risk for active TB. DESIGN: We administered a behavioral and demographic survey to 1317 inmates in two prison facilities in Sughd province, Tajikistan along with radiographic screening for pulmonary TB. Suspected cases were confirmed bacteriologically. Inmates undergoing TB treatment were also surveyed. In-depth interviews were conducted with former prisoners to elicit relevant social and behavioral characteristics. RESULTS: We identified 59 cases of active pulmonary TB (prevalence 4.5%. Factors independently associated with increased prevalence of active TB were: HIV-infection by self-report (PR 7.88; 95%CI 3.40-18.28, history of previous TB (PR 10.21; 95%CI 6.27-16.63 and infrequent supplemental nutrition beyond scheduled meals (PR 3.00; 95%CI 1.67-5.62. Access to supplemental nutrition was associated with frequency of visits from friends and family and ability to rely on other inmates for help. CONCLUSION: In prison facilities of Tajikistan, HIV-infection, injection drug use and low access to supplemental nutrition were associated with prevalent cases of active pulmonary TB. Policies that reduce HIV transmission among injection drug users and improve the nutritional status of socially isolated inmates may alleviate the TB burden in Tajikistan's prisons.

  1. Spanking, corporal punishment and negative long-term outcomes: a meta-analytic review of longitudinal studies.

    Science.gov (United States)

    Ferguson, Christopher J

    2013-02-01

    Social scientists continue to debate the impact of spanking and corporal punishment (CP) on negative child outcomes including externalizing and internalizing behavior problems and cognitive performance. Previous meta-analytic reviews have mixed long- and short-term studies and relied on bivariate r, which may inflate effect sizes. The current meta-analysis focused on longitudinal studies, and compared effects using bivariate r and better controlled partial r coefficients controlling for time-1 outcome variables. Consistent with previous findings, results based on bivariate r found small but non-trivial long-term relationships between spanking/CP use and negative outcomes. Spanking and CP correlated .14 and .18 respectively with externalizing problems, .12 and .21 with internalizing problems and -.09 and -.18 with cognitive performance. However, when better controlled partial r coefficients (pr) were examined, results were statistically significant but trivial (at or below pr = .10) for externalizing (.07 for spanking, .08 for CP) and internalizing behaviors (.10 for spanking, insufficient studies for CP) and near the threshold of trivial for cognitive performance (-.11 for CP, insufficient studies for spanking). It is concluded that the impact of spanking and CP on the negative outcomes evaluated here (externalizing, internalizing behaviors and low cognitive performance) are minimal. It is advised that psychologists take a more nuanced approach in discussing the effects of spanking/CP with the general public, consistent with the size as well as the significance of their longitudinal associations with adverse outcomes.

  2. A Novel Soybean ERF Transcription Factor, GmERF113, Increases Resistance to Phytophthora sojae Infection in Soybean

    Science.gov (United States)

    Zhao, Yuanling; Chang, Xin; Qi, Dongyue; Dong, Lidong; Wang, Guangjin; Fan, Sujie; Jiang, Liangyu; Cheng, Qun; Chen, Xi; Han, Dan; Xu, Pengfei; Zhang, Shuzhen

    2017-01-01

    Phytophthora root and stem rot of soybean caused by the oomycete Phytophthora sojae, is a destructive disease worldwide. Ethylene response factors (ERFs) play important roles in regulating plant biotic and abiotic stress tolerance. In this study, a new ERF gene, GmERF113, was isolated from the highly resistant soybean ‘Suinong 10.’ Sequence analysis suggested that the protein encoded by GmERF113 contained a conserved AP2/ERF domain of 58 amino acid and belonged to the B-4 subgroup of the ERF subfamily. Expression of GmERF113 was significantly induced by P. sojae, ethylene, and methyl jasmonate. GmERF113 protein localized to the nucleus when transiently expressed in Arabidopsis protoplasts, could bind to the GCC-box, and acted as a transcription activator. In addition, a region of the full-length GmERF113, GmERF113-II, interacted with a basic helix-loop-helix transcription factor (GmbHLH) in yeast cells. Full-length GmERF113 also interacted with GmbHLH in planta. GmERF113-overexpressing transgenic plants in susceptible cultivar ‘Dongnong 50’ soybean exhibited increased resistance to P. sojae and positively regulated the expression of the pathogenesis-related genes, PR1 and PR10-1. These results indicate that GmERF113 may play a crucial role in the defense of soybean against P. sojae infection. PMID:28326092

  3. Molecular cloning of the apoptosis-related calcium-binding protein AsALG-2 in Avena sativa.

    Science.gov (United States)

    Hoat, Trinh Xuan; Nakayashiki, Hitoshi; Yang, Qian; Tosa, Yukio; Mayama, Shigeyuki

    2013-04-01

    Victorin, the host-selective toxin produced by the fungus Cochliobolus victoriae, induces programmed cell death (PCD) in victorin-sensitive oat lines with characteristic features of animal apoptosis, such as mitochondrial permeability transition, chromatin condensation, nuclear DNA laddering and rRNA/mRNA degradation. In this study, we characterized a calcium-binding protein, namely AsALG-2, which might have a role in the victorin-induced PCD. AsALG-2 is homologous to the Apoptosis-Linked Gene ALG-2 identified in mammalian cells. Northern blot analysis revealed that the accumulation of AsALG-2 transcripts increased during victorin-induced PCD, but not during necrotic cell death. Salicylic acid, chitosan and chitin strongly activated the expression of general defence response genes, such as PR-10; however, neither induced cell death nor the accumulation of AsALG-2 mRNA. Pharmacological studies indicated that victorin-induced DNA laddering and AsALG-2 expression were regulated through similar pathways. The calcium channel blocker, nifedipine, moderately inhibited the accumulation of AsALG-2 mRNA during cell death. Trifluoperazine (calmodulin antagonist) and K252a (serine-threonine kinase inhibitor) reduced the victorin-induced phytoalexin accumulation, but did not prevent the victorin-induced DNA laddering or accumulation of AsALG-2 mRNA. Taken together, our investigations suggest that there is a calcium-mediated signalling pathway in animal and plant PCD in common.

  4. Effectiveness of boron neutron capture therapy for recurrent head and neck malignancies

    Energy Technology Data Exchange (ETDEWEB)

    Kato, Itsuro [Department of Oral and Maxillofacial Surgery, II Osaka University, Graduate School of Dentistry, Osaka (Japan)], E-mail: katoitsu@dent.osaka-u.ac.jp; Fujita, Yusei [Department of Oral and Maxillofacial Surgery, II Osaka University, Graduate School of Dentistry, Osaka (Japan); Maruhashi, Akira [Radiation Oncology Research Laboratory, Research Reactor Institut, Kyoto University, Osaka (Japan); Kumada, Hiroaki [Japan Atomic Energy Agency, Tokai Research and Development Center, Ibaraki (Japan); Ohmae, Masatoshi [Department of Oral and Maxillofacial Surgery, Izimisano Municipal Hospital, Rinku General Hospital, Izumisano, Osaka (Japan); Kirihata, Mitsunori [Graduate School of Environment and Life Science, Osaka prefectural University, Osaka (Japan); Imahori, Yoshio [Department of Neurosurgery, Kyoto Prefectural University, Kyoto (Japan); CEO of Cancer Intelligence Care Systems, Inc., Tokyo (Japan); Suzuki, Minoru [Radiation Oncology Research Laboratory, Research Reactor Institut, Kyoto University, Osaka (Japan); Sakrai, Yoshinori [Graduate School of Medicine, Sapporo Medical University of Medicine, Hokkaido (Japan); Sumi, Tetsuro; Iwai, Soichi; Nakazawa, Mitsuhiro [Department of Oral and Maxillofacial Surgery, II Osaka University, Graduate School of Dentistry, Osaka (Japan); Murata, Isao; Miyamaru, Hiroyuki [Division of Electrical, Electronic and Information Engineering, Graduate School of Engineering, Osaka University (Japan); Ono, Koji [Radiation Oncology Research Laboratory, Research Reactor Institut, Kyoto University, Osaka (Japan)

    2009-07-15

    It is necessary to explore new treatments for recurrent head and neck malignancies (HNM) to avoid severe impairment of oro-facial structures and functions. Boron neutron capture therapy (BNCT) is tumor-cell targeted radiotherapy that has significant superiority over conventional radiotherapies in principle. We have treated with BNCT 42 times for 26 patients (19 squamous cell carcinomas (SCC), 4 salivary gland carcinomas and 3 sarcomas) with a recurrent and far advanced HNM since 2001. Results of (1) {sup 10}B concentration of tumor/normal tissue ratios (T/N ratio) of FBPA-PET studies were SCC: 1.8-5.7, sarcoma: 2.5-4.0, parotid tumor: 2.5-3.7. (2) Therapeutic effects were CR: 12 cases, PR: 10 cases, PD: 3 cases NE (not evaluated): 1 case. Response rate was 85%. (3) Improvement of QOL such as a relief of severe pain, bleeding, and exudates at the local lesion, improvement of PS, disappearance of ulceration, covered with normal skin and preserved oral and maxillofacial functions and tissues. (4) Survival periods after BNCT were 1-72 months (mean: 13.6 months). Six-year survival rate was 24% by Kaplan-Meier analysis. (5) Adverse-events were transient mucositis and alopecia in most of the cases; three osteomyelitis and one brain necrosis were recognized. These results indicate that BNCT represents a new and promising treatment approach for advanced HNM.

  5. Changes in leaf proteome profile of Arabidopsis thaliana in response to salicylic acid

    Indian Academy of Sciences (India)

    Riddhi Datta; Ragini Sinha; Sharmila Chattopadhyay

    2013-06-01

    Salicylic acid (SA) has been implicated in determining the outcome of interactions between many plants and their pathogens. Global changes in response to this phytohormone have been observed at the transcript level, but little is known of how it induces changes in protein abundance. To this end we have investigated the effect of 1 mM SA on soluble proteins of Arabidopsis thaliana leaves by proteomic analysis. An initial study at transcript level has been performed on temporal landscape, which revealed that induction of most of the SA-responsive genes occurs within 3 to 6 h post treatment (HPT) and the expression peaked within 24 HPT. Two-dimensional gel electrophoresis (2-DE) coupled with MALDI-TOF MS/MS analysis has been used to identify differentially expressed proteins and 63 spots have been identified successfully. This comparative proteomic profiling of SA treated leaves versus control leaves demonstrated the changes of many defence related proteins like pathogenesis related protein 10a (PR10a), disease-resistance-like protein, putative late blight-resistance protein, WRKY4, MYB4, etc. along with gross increase in the rate of energy production, while other general metabolism rate is slightly toned down, presumably signifying a transition from ‘normal mode’ to ‘defence mode’.

  6. The bacterial superoxide dismutase and glutathione reductase are crucial for endophytic colonization of rice roots by Gluconacetobacter diazotrophicus PAL5.

    Science.gov (United States)

    Alquéres, Sylvia; Meneses, Carlos; Rouws, Luc; Rothballer, Michael; Baldani, Ivo; Schmid, Michael; Hartmann, Anton

    2013-08-01

    Gluconacetobacter diazotrophicus is an aerobic diazotrophic plant-growth-promoting bacterium isolated from different gramineous plants. We showed that reactive oxygen species (ROS) were produced at early stages of rice root colonization, a typical plant defense response against pathogens. The transcription of the pathogen-related-10 gene of the jasmonic acid (JA) pathway but not of the PR-1 gene of the salicylic acid pathway was activated by the endophytic colonization of rice roots by G. diazotrophicus strain PAL5. Quantitative polymerase chain reaction analyses showed that, at early stages of colonization, the bacteria upregulated the transcript levels of ROS-detoxifying genes such as superoxide dismutase (SOD) and glutathione reductase (GR). To proof the role of ROS-scavenging enzymes in the colonization and interaction process, transposon insertion mutants of the SOD and GR genes of strain PAL5 were constructed. The SOD and GR mutants were unable to efficiently colonize the roots, indicated by the decrease of tightly root-associated bacterial cell counts and endophytic colonization and by fluorescence in situ hybridization analysis. Interestingly, the mutants did not induce the PR-10 of the JA-pathway, probably due to the inability of endophytic colonization. Thus, ROS-scavenging enzymes of G. diazotrophicus strain PAL5 play an important role in the endophytic colonization of rice plants.

  7. Molecular and biochemical classification of plant-derived food allergens.

    Science.gov (United States)

    Breiteneder, H; Ebner, C

    2000-07-01

    Molecular biology and biochemical techniques have significantly advanced the knowledge of allergens derived from plant foods. Surprisingly, many of the known plant food allergens are homologous to pathogenesis-related proteins (PRs), proteins that are induced by pathogens, wounding, or certain environmental stresses. PRs have been classified into 14 families. Examples of allergens homologous to PRs include chitinases (PR-3 family) from avocado, banana, and chestnut; antifungal proteins such as the thaumatin-like proteins (PR-5) from cherry and apple; proteins homologous to the major birch pollen allergen Bet v 1 (PR-10) from vegetables and fruits; and lipid transfer proteins (PR-14) from fruits and cereals. Allergens other than PR homologs can be allotted to other well-known protein families such as inhibitors of alpha-amylases and trypsin from cereal seeds, profilins from fruits and vegetables, seed storage proteins from nuts and mustard seeds, and proteases from fruits. As more clinical data and structural information on allergenic molecules becomes available, we may finally be able to answer what characteristics of a molecule are responsible for its allergenicity.

  8. HTP方案治疗晚期非小细胞肺癌的临床观察%Therapeutic Efficacy of HTP Regimen in Patients with Advanced Non-small Cell Lung Cancer

    Institute of Scientific and Technical Information of China (English)

    龚新雷; 秦叔逵; 何泽明; 王琳; 钱军; 陈映霞

    2003-01-01

    目的观察采用羟基喜树碱(HPT)、鬼臼噻吩甙(VM-26)和顺铂(PDD)组成的HTP方案,治疗晚期非小细胞肺癌(NSCLC)的近期疗效及其不良反应.方法31例晚期NSCLC患者,应用HTP方案,即HPT 6 mg/m2,静脉滴注,第1~5天;VM-26 60 mg/m2,静脉滴注,第1~4天;PDD 20 mg/天,静脉滴注,第1~5天.每28天重复,用药2个周期后按照WHO标准进行评价.结果31例患者中CR 1例,PR 10例,NC 12例,PD 8例,总有效率为35.5%;主要不良反应为骨髓抑制和消化道反应.结论HTP方案治疗NSCLC的疗效较高,不良反应可以耐受,值得进一步临床观察.

  9. Silencing of sterol glycosyltransferases modulates the withanolide biosynthesis and leads to compromised basal immunity of Withania somnifera

    Science.gov (United States)

    Singh, Gaurav; Tiwari, Manish; Singh, Surendra Pratap; Singh, Surendra; Trivedi, Prabodh Kumar; Misra, Pratibha

    2016-01-01

    Sterol glycosyltransferases (SGTs) catalyse transfer of glycon moiety to sterols and their related compounds to produce diverse glyco-conjugates or steryl glycosides with different biological and pharmacological activities. Functional studies of SGTs from Withania somnifera indicated their role in abiotic stresses but details about role under biotic stress are still unknown. Here, we have elucidated the function of SGTs by silencing SGTL1, SGTL2 and SGTL4 in Withania somnifera. Down-regulation of SGTs by artificial miRNAs led to the enhanced accumulation of withanolide A, withaferin A, sitosterol, stigmasterol and decreased content of withanoside V in Virus Induced Gene Silencing (VIGS) lines. This was further correlated with increased expression of WsHMGR, WsDXR, WsFPPS, WsCYP710A1, WsSTE1 and WsDWF5 genes, involved in withanolide biosynthesis. These variations of withanolide concentrations in silenced lines resulted in pathogen susceptibility as compared to control plants. The infection of Alternaria alternata causes increased salicylic acid, callose deposition, superoxide dismutase and H2O2 in aMIR-VIGS lines. The expression of biotic stress related genes, namely, WsPR1, WsDFS, WsSPI and WsPR10 were also enhanced in aMIR-VIGS lines in time dependent manner. Taken together, our observations revealed that a positive feedback regulation of withanolide biosynthesis occurred by silencing of SGTLs which resulted in reduced biotic tolerance. PMID:27146059

  10. Autoportree : [luuletused] / Artur Alliksaar ; [Impressioonid] : Viiu Härm

    Index Scriptorium Estoniae

    Alliksaar, Artur, 1923-1966

    2004-01-01

    õmbeid kottpimedas galeriis ; Ärklituba ; Hommik ei oota õhtut ; Improvisatsioone harfil ; Morbiidseid maastikke ; Sõnad sinule, surm, suurele vaikusele ja iseendale ; Õhtute kollane tolm ; Kõik on kõige peegeldus ; Kas süvenev sügis viib sinugi ?... ; Kolm kosmogoonilist etüüdi ; Interregnum ; Neli etüüdi ; Üks vari laulis apelsinisalus. Ta vaevalt lõpetas, kui unus, kes ja kus ; Ürgmetsas ; Tuleb ingel ja puudutab vett ; Lahkusid, kui loojus kuu ; Rändur on teel... ; Mis saab sellest loomusevalust? ; Läbi selle metsa olen näinud ; Kuskil ajajõe taga ; Aeg

  11. 中国HIV-1 CRF01_AE流行株结构基因和调节/辅助基因DNA疫苗的构建和免疫原性研究%Immunogenicity of DNA vaccines encoding structural proteins and regulatory/accessory proteins derived from an HIV-1 CRF01_AE isolate circulating in China

    Institute of Scientific and Technical Information of China (English)

    袁松华; 徐建青; 万延民; 仇超; 张聪优; 黄杨; 乔勇; 叶芮琪; 邱趁丽; 张晓燕

    2010-01-01

    specific band at molecular mass 220×10~3 in lane of pSVAE/GE transfeeted 293T cell and a specific band at 95×10~3 in the lane of pSVAE/TRIVN. Both DNA vaccines mounted significant specific T cell responses with (3010 ± 566) SFC/10~6 splenocytes for DNA vaccine pSV AE/GE and (948 ± 737) SFC/10~6 spleno-cytes for DNA vaccine pSVAE/TRIVN, whereas the mock control of pDRVISV1.0 only raised marginal T cell responses. Conclusion Both pSVAE/GE and pSVAE/TRIVN were capable of expressing the inserted fusion immunogen genes and able to elicit vigorous cellular immune responses, therefore, these DNA vac-cines are highly immunogenic.

  12. Ef fect of Tradition and Innovation on an Actor’s Work Over Time: The example of Salme Reek. Traditsiooni ja uuenduse mõju näitlejaloomingule läbi aja: Salme Reegi näide

    Directory of Open Access Journals (Sweden)

    Eike Värk

    2012-04-01

    Full Text Available Ühiskondliku situatsiooni muutumine toob kaasa muutused teatri repertuaaris, väljendusvahendite valikus, esteetilistes tõekspidamistes jne. Ajas muutub ka näitleja osa, tema olemus, tähendus ning näitleja-vaataja suhe teatriprotsessis. Näitlejale on oluline näha teatrit dünaamilises arengus ja ise uuega kaasa minna. Jälgin kahe vastandliku jõu – traditsiooni ja uuenduse – mõju näitleja loomingule eesti teatri ühe legendi Salme Reegi (1907–1996 teatritee näitel. Selle nimega seostub ligi seitse aastakümmet eesti kutselise teatri saja-aastasest ajaloost. Reegi näitlejaks kujunemine algas Draamastuudios (1927–1930, kus ta sai traditsiooniliseks peetava realistliku, läbielamiskunstil põhineva näitlejakoolituse. See oli baas toimetulekuks erinevate teatristiilidega, traditsioonilises ja uuenduslikus teatris, erineva tinglikkuseastmega lavastustes, nii „läbielamisteatris“ kui ka „etendamisteatris“. Kooli lõpetamise järel asus ta tööle Eesti Draamateatrisse, kuhu jäi kuni oma surmani. Reegi teatriaja esimene aastakümme kulges elulähedust ja eesti kultuuri eripära väärtustavas teatris. Neil aastail oli tal sageli võimalus mängida paralleelselt väikesi lapsi ja vanu naisi. Poisterollidest kujunes tema kui näitleja fenomen. Arvukatele vanaeiderollidedele andis ta sageli groteskse värvingu. Nõukogude okupatsioon ja sõjajärgne aeg tõi Reegile mitmeid lapskangelaste rolle. 1960ndate teisel poolel ja 1970ndail pidi Reek kohanema uusi vorme otsiva mängulise teatriga. 1962. aastal sündis Ibseni „Peer Gyntis“ legendaarne ema Åse, mille loomisel oli olulisel kohal näitleja füüsiline eneseväljendus, selle seos sisemise vaimsuse ning näitleja enese ereda isikupära esiletoomisega. 1970ndate lõpul sai seitsmekümnendates eluaastates, kuid särav ja suurepärase plastilise liikumisega Reek võimaluse näitlemiseks teatraalsemas ja koomilisemas laadis Ago-Endrik Kerge lavastustes. 1980. aastate

  13. Connections between the thalamus and the somatosensory areas of the anterior ectosylvian gyrus in the cat.

    Science.gov (United States)

    Burton, H; Kopf, E M

    1984-04-01

    labeled other parts of the posterior complex but failed to label any part of VB except when the injection mass also diffused into SII. Injections into the somatic sensory cortex located lateral to SII, within the lips and depth of the upper bank of the anterior ectosylvian sulcus (AES), heavily labeled the central and posterior portions of Pom. Substantial labeling was noted in the lateral (Pol) and intermediate (Poi) divisions of Po only when the injections involved some part of the auditory areas located immediately posterior to SII. This region included the anterior auditory area that occupies the most posterior part of the AEG and both banks of the immediately adjoining AES. The magnocellular nucleus of the medial geniculate (MGmc) was labeled only when some part of the auditory cortex was injected. The suprageniculate nucleus (SG) was labeled from the insula and lower bank of the AES. These results indicated that the medial (rostral and caudal Pom) and lateral components (Poi, Pol, MGmc) of the posterior complex have separate cortical projection zones to somatic sensory and auditory cortical regions, respectively. SIV and the lateral extent of area 5a located in the medial bank of the anterior suprasylvian sulcus sent projections to the deep layers of the superior colliculus and the ventrolateral periaqueductal gray. No cortico-tectal projections were seen from SII.

  14. Plant root transcriptome profiling reveals a strain-dependent response during Azospirillum-rice cooperation

    Directory of Open Access Journals (Sweden)

    Benoît eDrogue

    2014-11-01

    Full Text Available Cooperation involving Plant Growth-Promoting Rhizobacteria results in improvements of plant growth and health. While pathogenic and symbiotic interactions are known to induce transcriptional changes for genes related to plant defence and development, little is known about the impact of phytostimulating rhizobacteria on plant gene expression. This study aims at identifying genes significantly regulated in rice roots upon Azospirillum inoculation, considering possible favored interaction between a strain and its original host cultivar. Genome-wide analyses of Oryza sativa japonica cultivars Cigalon and Nipponbare were performed, by using microarrays, seven days post inoculation with A. lipoferum 4B (isolated from Cigalon or Azospirillum sp. B510 (isolated from Nipponbare and compared to the respective non-inoculated condition. A total of 7,384 genes were significantly regulated, which represent about 16 % of total rice genes. A set of 34 genes is regulated by both Azospirillum strains in both cultivars, including a gene orthologous to PR10 of Brachypodium, and these could represent plant markers of Azospirillum-rice interactions. The results highlight a strain-dependent response of rice, with 83 % of the differentially expressed genes being classified as combination-specific. Whatever the combination, most of the differentially expressed genes are involved in primary metabolism, transport, regulation of transcription and protein fate. When considering genes involved in response to stress and plant defence, it appears that strain B510, a strain displaying endophytic properties, leads to the repression of a wider set of genes than strain 4B. Individual genotypic variations could be the most important driving force of rice roots gene expression upon Azospirillum inoculation. Strain-dependent transcriptional changes observed for genes related to auxin and ethylene signalling highlight the complexity of hormone signalling networks in the Azospirillum

  15. 妊娠晚期心电图的异常分析%Analysis of ECG Abnormalities in Late Pregnancy

    Institute of Scientific and Technical Information of China (English)

    吐逊古•阿西木; 迪丽拜尔•克尤木

    2014-01-01

    Objective The ecg changes in late pregnancy women and the relationship between the clinical and treatment method.Methods The guangdong state built ECG- 9803 type routine eeg, ECG machine, analysis the change of electrocardiogram (ECG), 148 cases of late pregnancy women.Results The types of abnormal ecg in 148 cases of late pregnancy women were,electrical axis left 75 cases,40 cases of sinus tachycardia,sinus arrhythmia,12 cases were shortened period between P-R 10 cases,5 cases of premature beat,QRS low voltage 4 cases,S T-T change in 2 cases.Conclusion See more quite late pregnancy women abnormal ecg, should be focus on change, timely intervention treatment when necessary, to ensure life safety of pregnant women and fetus.%目的探讨妊娠晚期妇女心电图改变与临床的关系及处理方法。方法采用美国M 1772A型心电图机进行常规描记,分析148例妊娠晚期女性的心电图的改变。结果148例孕晚期妇女中心电图异常的种类分别是,电轴左偏75例,窦性心动过速40例、窦性心律不齐12例,P-R间期缩短10例、早搏5例、QRS低电压4例,ST-T改变2例。结论妊娠晚期妇女心电图异常比较多见,应予关注改变,必要时及时进行干预治疗,以保障孕妇和胎儿的生命安全。

  16. Studies on the mechanism of resistance to Bipolaris sorokiniana in the barley lesion mimic mutant bst1.

    Science.gov (United States)

    Persson, Mattias; Falk, Anders; Dixelius, Christina

    2009-09-01

    SUMMARY The Bipolaris sorokiniana tolerant 1 (bst1) barley mutant is derived from fast neutron-irradiated seeds of wild-type Bowman(Rph3). The induced mutation was genetically localized to a position on chromosome 5HL distal to the centromere using amplified fragment length polymorphism markers. In addition, the defence responses and related gene expression in the bst1 mutant after fungal challenge were compared with those occurring in wild-type plants. Hydrogen peroxide generation, determined by 3,3-diaminobenzidine staining, revealed a clearly reduced level of bst1, compared with the wild-type, during the entire experimental time: 8-120 h post-inoculation (hpi). At 48 hpi, the wild-type samples displayed twice as much fungal mass and three times greater H(2)O(2) production than bst1. At the same time, staining of B. sorokiniana showed less fungal growth in the spontaneous lesions of bst1 compared with the wild-type. Monitoring of defence-related genes at 48 hpi demonstrated strong expression of PR-1a, PR-2, PR-5 and PR-10 in bst1. A gene coding for a unique oxidoreductase enzyme, designated as HCP1, was expressed at much higher levels in inoculated leaves of the bst1 mutant than in those of the wild-type plant. Taken together, the results suggest that the defence to B. sorokiniana largely relies on salicylic acid-responsive pathogenesis-related (PR) genes, as well as selected reactive oxygen species and unknown HCP1-associated factors.

  17. Prevalence of cervical intraepithelial neoplasia grades II/III and cervical cancer in patients with cytological diagnosis of atypical squamous cells when high-grade intraepithelial lesions (ASC-H cannot be ruled out

    Directory of Open Access Journals (Sweden)

    Andréa Cytryn

    Full Text Available CONTEXT AND OBJECTIVE: The latest update of the Bethesda System divided the category of atypical squamous cells of undetermined significance (ASCUS into ASC-US (undetermined significance and ASC-H (high-grade intraepithelial lesion cannot be ruled out. The aims here were to measure the prevalence of pre-invasive lesions (cervical intraepithelial neoplasia, CIN II/III and cervical cancer among patients referred to Instituto Fernandes Figueira (IFF with ASC-H cytology, and compare them with ASC-US cases. DESIGN AND SETTING: Cross-sectional study with retrospective data collection, at the IFF Cervical Pathology outpatient clinic. METHODS: ASCUS cases referred to IFF from November 1997 to September 2007 were reviewed according to the 2001 Bethesda System to reach cytological consensus. The resulting ASC-H and ASC-US cases, along with new cases, were analyzed relative to the outcome of interest. The histological diagnosis (or cytocolposcopic follow-up in cases without such diagnosis was taken as the gold standard. RESULTS: The prevalence of CIN II/III in cases with ASC-H cytology was 19.29% (95% confidence interval, CI, 9.05-29.55% and the risk of these lesions was greater among patients with ASC-H than with ASC-US cytology (prevalence ratio, PR, 10.42; 95% CI, 2.39-45.47; P = 0.0000764. Pre-invasive lesions were more frequently found in patients under 50 years of age with ASC-H cytology (PR, 2.67; 95% CI, 0.38-18.83; P = 0.2786998. There were no uterine cervical cancer cases. CONCLUSION: The prevalence of CIN II/III in patients with ASC-H cytology was significantly higher than with ASC-US, and division into ASC diagnostic subcategories had good capacity for discriminating the presence of pre-invasive lesions.

  18. Stimulus-dependent, promoter-specific binding of transcription factor WRKY1 to Its native promoter and the defense-related gene PcPR1-1 in Parsley.

    Science.gov (United States)

    Turck, Franziska; Zhou, Aifen; Somssich, Imre E

    2004-10-01

    WRKY transcription factors form a large family that plays a role in plant responses to biotic stress and during senescence. Defining in vivo relevant WRKY/promoter relationships has been hampered by the factors' indiscriminate binding to known W box DNA elements and their possible genetic redundance. Employing chromatin immunoprecipitations (ChIP) of cultured cells, we show that parsley (Petroselinum crispum) WRKY1 protein binds to the W boxes of its native promoter as well as to that of PcWRKY3 and the defense-related PR10-class marker gene Pathogenesis-Related1-1 (PcPR1-1). Although present at low concentrations in resting cells, WRKY1 does not appear to play a role in the immediate early gene response upon elicitation because it does not bind to the promoter at this time. Paradoxically, in vivo binding at the PcWRKY1 promoter correlates more with downregulation of gene expression, whereas previous overexpression studies suggested an activating function of WRKY1 on PcWRKY1 expression. By contrast, PcPR1-1 expression remains strong when its promoter is occupied in vivo by WRKY1. Unexpectedly, ChIP revealed that W boxes at promoter sites are constitutively occupied by other WRKY transcription factors, indicating that site recruitment does not seem to play a major role in their regulation. Rather, WRKY proteins very likely act in a network of mutually competing participants with temporal displacement occurring at defined preoccupied sites by other family members in a stimulus-dependent manner.

  19. Reprogramming of Strawberry (Fragaria vesca) Root Transcriptome in Response to Phytophthora cactorum.

    Science.gov (United States)

    Toljamo, Anna; Blande, Daniel; Kärenlampi, Sirpa; Kokko, Harri

    2016-01-01

    Crown rot (Phytophthora cactorum) causes significant economic losses in strawberry production. The best control strategy would be to use resistant cultivars, but polygenically inherited resistance makes the breeding of the garden strawberry (Fragaria × ananassa) challenging. The diploid wild strawberry Fragaria vesca Hawaii 4 genotype was shown previously to have resistance against crown rot. To explore the resistance mechanisms, we inoculated the roots of Hawaii 4 with P. cactorum in a novel in vitro hydroponic system to minimize interference caused by other microbes. Major reprogramming of the root transcriptome occurred, involving 30% of the genes. The surveillance system of the plant shifted from the development mode to the defense mode. Furthermore, the immune responses as well as many genes involved in the biosynthesis of the defense hormones jasmonic acid, ethylene and salicylic acid were up-regulated. Several major allergen-like genes encoding PR-10 proteins were highly expressed in the inoculated plants, suggesting that they also have a crucial role in the defense responses against P. cactorum. Additionally, flavonoids and terpenoids may be of vital importance, as several genes involved in their biosynthesis were up-regulated. The cell wall biosynthesis and developmental processes were down-regulated, possibly as a result of the down-regulation of the key genes involved in the biosynthesis of growth-promoting hormones brassinosteroids and auxin. Of particular interest was the expression of potential resistance genes in the recently identified P. cactorum resistance locus RPc-1. These new findings help to target the breeding efforts aiming at more resistant strawberry cultivars.

  20. Comprehensive mapping infection-enhancing epitopes of dengue pr protein using polyclonal antibody against prM.

    Science.gov (United States)

    Luo, Yayan; Guo, Xiaolan; Yan, Huijun; Fang, Danyun; Zeng, Gucheng; Zhou, Junmei; Jiang, Lifang

    2015-07-01

    Dengue vaccine development is considered a global public health priority, but the antibody-dependent enhancement (ADE) issues have critically restricted vaccine development. Recent findings have demonstrated that pre-membrane (prM) protein was involved in dengue virus (DENV) infection enhancement. Although the importance of prM antibodies have been well characterized, only a few epitopes in DENV prM protein have ever been identified. In this study, we screened five potential linear epitopes located at positions pr1 (1-16aa), pr3 (13-28aa), pr4 (19-34aa), pr9 (49-64aa), and pr10 (55-70aa) in pr protein using peptide scanning and comprehensive bioinformatics analysis. Then, we found that only pr4 (19-34aa) could elicit high-titer antibodies in Balb/c mice, and this epitope could react with sera from DENV2-infected patients, suggesting that specific antibodies against epitope peptide pr4 were elicited in both DENV-infected mice and human. In addition, our data demonstrated that anti-pr4 sera showed limited neutralizing activity but significant ADE activity toward standard DENV serotypes and imDENV. Hence, it seems responsible to hypothesize that anti-pr4 serum was infection-enhancing antibody and pr4 was infection-enhancing epitope. In conclusion, we characterized a novel infection-enhancing epitope on dengue pr protein, a finding that may provide new insight into the pathogenesis of DENV infection and contribute to dengue vaccine design.

  1. Partial Activation of SA- and JA-Defensive Pathways in Strawberry upon Colletotrichum acutatum Interaction.

    Science.gov (United States)

    Amil-Ruiz, Francisco; Garrido-Gala, José; Gadea, José; Blanco-Portales, Rosario; Muñoz-Mérida, Antonio; Trelles, Oswaldo; de Los Santos, Berta; Arroyo, Francisco T; Aguado-Puig, Ana; Romero, Fernando; Mercado, José-Ángel; Pliego-Alfaro, Fernando; Muñoz-Blanco, Juan; Caballero, José L

    2016-01-01

    Understanding the nature of pathogen host interaction may help improve strawberry (Fragaria × ananassa) cultivars. Plant resistance to pathogenic agents usually operates through a complex network of defense mechanisms mediated by a diverse array of signaling molecules. In strawberry, resistance to a variety of pathogens has been reported to be mostly polygenic and quantitatively inherited, making it difficult to associate molecular markers with disease resistance genes. Colletotrichum acutatum spp. is a major strawberry pathogen, and completely resistant cultivars have not been reported. Moreover, strawberry defense network components and mechanisms remain largely unknown and poorly understood. Assessment of the strawberry response to C. acutatum included a global transcript analysis, and acidic hormones SA and JA measurements were analyzed after challenge with the pathogen. Induction of transcripts corresponding to the SA and JA signaling pathways and key genes controlling major steps within these defense pathways was detected. Accordingly, SA and JA accumulated in strawberry after infection. Contrastingly, induction of several important SA, JA, and oxidative stress-responsive defense genes, including FaPR1-1, FaLOX2, FaJAR1, FaPDF1, and FaGST1, was not detected, which suggests that specific branches in these defense pathways (those leading to FaPR1-2, FaPR2-1, FaPR2-2, FaAOS, FaPR5, and FaPR10) were activated. Our results reveal that specific aspects in SA and JA dependent signaling pathways are activated in strawberry upon interaction with C. acutatum. Certain described defense-associated transcripts related to these two known signaling pathways do not increase in abundance following infection. This finding suggests new insight into a specific putative molecular strategy for defense against this pathogen.

  2. Partial activation of SA- and JA-defensive pathways in strawberry upon Colletotrichum acutatum interaction

    Directory of Open Access Journals (Sweden)

    FRANCISCO AMIL-RUIZ

    2016-07-01

    Full Text Available Understanding the nature of pathogen host interaction may help improve strawberry (Fragaria × ananassa cultivars. Plant resistance to pathogenic agents usually operates through a complex network of defense mechanisms mediated by a diverse array of signaling molecules. In strawberry, resistance to a variety of pathogens has been reported to be mostly polygenic and quantitatively inherited, making it difficult to associate molecular markers with disease resistance genes. Colletotrichum acutatum spp. is a major strawberry pathogen, and completely resistant cultivars have not been reported. Moreover, strawberry defense network components and mechanisms remain largely unknown and poorly understood. Assessment of the strawberry response to C. acutatum included a global transcript analysis, and acidic hormones SA and JA measurements were analyzed after challenge with the pathogen. Induction of transcripts corresponding to the SA and JA signaling pathways and key genes controlling major steps within these defense pathways was detected. Accordingly, SA and JA accumulated in strawberry after infection. Contrastingly, induction of several important SA, JA, and oxidative stress-responsive defense genes, including FaPR1-1, FaLOX2, FaJAR1, FaPDF1, and FaGST1, was not detected, which suggests that specific branches in these defense pathways (those leading to FaPR1-2, FaPR2-1, FaPR2-2, FaAOS, FaPR5 and FaPR10 were activated. Our results reveal that specific aspects in SA and JA dependent signaling pathways are activated in strawberry upon interaction with C. acutatum. Certain described defense-associated transcripts related to these two known signaling pathways do not increase in abundance following infection. This finding suggests new insight into a specific putative molecular strategy for defense against this pathogen.

  3. Expression profiles of hot pepper (Capsicum annuum) genes under cold stress conditions

    Indian Academy of Sciences (India)

    Eul-Won Hwang; Kyung-A Kim; Soo-Chul Park; Mi-Jeong Jeong; Myung-Ok Byun; Hawk-Bin Kwon

    2005-12-01

    In an attempt to determine a cold defense mechanism in plants, we have attempted to characterize changes occurring in the expression of cold-regulated transcript levels in the hot pepper (Capsicum annuum), using cDNA microarray analysis, combined with Northern blot analysis. After analysing a 3.1 K hot pepper cDNA microarray, we isolated a total of 317 cold inducible genes. We selected 42 genes which were up-regulated and three genes which were down-regulated due to cold treatment, for further analysis. Among the 45 genes which appeared to be up-regulated by cold, 19 genes appeared to be simultaneously regulated by salt stress. Among the up-regulated cold-stress genes, we identified a variety of transcription factors, including: a family of 4 ethylene-responsive element binding protein (EREBP, designated CaEREBP-C1 to C4) genes, a bZIP protein (CaBZ1), RVA1, Ring domain protein, HSF1, and the WRKY (CaWRKY1) protein. As mentioned earlier, several genes appeared to be induced not only by cold stress, but also simultaneously by salt stress. These genes included: CaEREBP-C3, CaBZ1, putative trans-activator factor, NtPRp27, malate dehydrogenase, putative auxin-repressed protein, protein phosphatase (CaTPP1), SAR8.2 protein precursor, late-embryogenesis abundant protein 5 (LEA5), DNAJ protein homologue, xyloglucanendo-1,4--D-gucanase precursor, PR10, and the putative non-specific lipid transfer protein StnsLTP.

  4. Induction of host defences by Rhizobium during ineffective nodulation of pea (Pisum sativum L.) carrying symbiotically defective mutations sym40 (PsEFD), sym33 (PsIPD3/PsCYCLOPS) and sym42.

    Science.gov (United States)

    Ivanova, Kira A; Tsyganova, Anna V; Brewin, Nicholas J; Tikhonovich, Igor A; Tsyganov, Viktor E

    2015-11-01

    Rhizobia are able to establish a beneficial interaction with legumes by forming a new organ, called the symbiotic root nodule, which is a unique ecological niche for rhizobial nitrogen fixation. Rhizobial infection has many similarities with pathogenic infection and induction of defence responses accompanies both interactions, but defence responses are induced to a lesser extent during rhizobial infection. However, strong defence responses may result from incompatible interactions between legumes and rhizobia due to a mutation in either macro- or microsymbiont. The aim of this research was to analyse different plant defence reactions in response to Rhizobium infection for several pea (Pisum sativum) mutants that result in ineffective symbiosis. Pea mutants were examined by histochemical and immunocytochemical analyses, light, fluorescence and transmission electron microscopy and quantitative real-time PCR gene expression analysis. It was observed that mutations in pea symbiotic genes sym33 (PsIPD3/PsCYCLOPS encoding a transcriptional factor) and sym40 (PsEFD encoding a putative negative regulator of the cytokinin response) led to suberin depositions in ineffective nodules, and in the sym42 there were callose depositions in infection thread (IT) and host cell walls. The increase in deposition of unesterified pectin in IT walls was observed for mutants in the sym33 and sym42; for mutant in the sym42, unesterified pectin was also found around degrading bacteroids. In mutants in the genes sym33 and sym40, an increase in the expression level of a gene encoding peroxidase was observed. In the genes sym40 and sym42, an increase in the expression levels of genes encoding a marker of hypersensitive reaction and PR10 protein was demonstrated. Thus, a range of plant defence responses like suberisation, callose and unesterified pectin deposition as well as activation of defence genes can be triggered by different pea single mutations that cause perception of an otherwise

  5. Co-inoculation with rhizobia and AMF inhibited soybean red crown rot: from field study to plant defense-related gene expression analysis.

    Directory of Open Access Journals (Sweden)

    Xiang Gao

    Full Text Available BACKGROUND: Soybean red crown rot is a major soil-borne disease all over the world, which severely affects soybean production. Efficient and sustainable methods are strongly desired to control the soil-borne diseases. PRINCIPAL FINDINGS: We firstly investigated the disease incidence and index of soybean red crown rot under different phosphorus (P additions in field and found that the natural inoculation of rhizobia and arbuscular mycorrhizal fungi (AMF could affect soybean red crown rot, particularly without P addition. Further studies in sand culture experiments showed that inoculation with rhizobia or AMF significantly decreased severity and incidence of soybean red crown rot, especially for co-inoculation with rhizobia and AMF at low P. The root colony forming unit (CFU decreased over 50% when inoculated by rhizobia and/or AMF at low P. However, P addition only enhanced CFU when inoculated with AMF. Furthermore, root exudates of soybean inoculated with rhizobia and/or AMF significantly inhibited pathogen growth and reproduction. Quantitative RT-PCR results indicated that the transcripts of the most tested pathogen defense-related (PR genes in roots were significantly increased by rhizobium and/or AMF inoculation. Among them, PR2, PR3, PR4 and PR10 reached the highest level with co-inoculation of rhizobium and AMF. CONCLUSIONS: Our results indicated that inoculation with rhizobia and AMF could directly inhibit pathogen growth and reproduction, and activate the plant overall defense system through increasing PR gene expressions. Combined with optimal P fertilization, inoculation with rhizobia and AMF could be considered as an efficient method to control soybean red crown rot in acid soils.

  6. Interspecific proteomic comparisons reveal ash phloem genes potentially involved in constitutive resistance to the emerald ash borer.

    Directory of Open Access Journals (Sweden)

    Justin G A Whitehill

    Full Text Available The emerald ash borer (Agrilus planipennis is an invasive wood-boring beetle that has killed millions of ash trees since its accidental introduction to North America. All North American ash species (Fraxinus spp. that emerald ash borer has encountered so far are susceptible, while an Asian species, Manchurian ash (F. mandshurica, which shares an evolutionary history with emerald ash borer, is resistant. Phylogenetic evidence places North American black ash (F. nigra and Manchurian ash in the same clade and section, yet black ash is highly susceptible to the emerald ash borer. This contrast provides an opportunity to compare the genetic traits of the two species and identify those with a potential role in defense/resistance. We used Difference Gel Electrophoresis (DIGE to compare the phloem proteomes of resistant Manchurian to susceptible black, green, and white ash. Differentially expressed proteins associated with the resistant Manchurian ash when compared to the susceptible ash species were identified using nano-LC-MS/MS and putative identities assigned. Proteomic differences were strongly associated with the phylogenetic relationships among the four species. Proteins identified in Manchurian ash potentially associated with its resistance to emerald ash borer include a PR-10 protein, an aspartic protease, a phenylcoumaran benzylic ether reductase (PCBER, and a thylakoid-bound ascorbate peroxidase. Discovery of resistance-related proteins in Asian species will inform approaches in which resistance genes can be introgressed into North American ash species. The generation of resistant North American ash genotypes can be used in forest ecosystem restoration and urban plantings following the wake of the emerald ash borer invasion.

  7. Interspecific proteomic comparisons reveal ash phloem genes potentially involved in constitutive resistance to the emerald ash borer.

    Science.gov (United States)

    Whitehill, Justin G A; Popova-Butler, Alexandra; Green-Church, Kari B; Koch, Jennifer L; Herms, Daniel A; Bonello, Pierluigi

    2011-01-01

    The emerald ash borer (Agrilus planipennis) is an invasive wood-boring beetle that has killed millions of ash trees since its accidental introduction to North America. All North American ash species (Fraxinus spp.) that emerald ash borer has encountered so far are susceptible, while an Asian species, Manchurian ash (F. mandshurica), which shares an evolutionary history with emerald ash borer, is resistant. Phylogenetic evidence places North American black ash (F. nigra) and Manchurian ash in the same clade and section, yet black ash is highly susceptible to the emerald ash borer. This contrast provides an opportunity to compare the genetic traits of the two species and identify those with a potential role in defense/resistance. We used Difference Gel Electrophoresis (DIGE) to compare the phloem proteomes of resistant Manchurian to susceptible black, green, and white ash. Differentially expressed proteins associated with the resistant Manchurian ash when compared to the susceptible ash species were identified using nano-LC-MS/MS and putative identities assigned. Proteomic differences were strongly associated with the phylogenetic relationships among the four species. Proteins identified in Manchurian ash potentially associated with its resistance to emerald ash borer include a PR-10 protein, an aspartic protease, a phenylcoumaran benzylic ether reductase (PCBER), and a thylakoid-bound ascorbate peroxidase. Discovery of resistance-related proteins in Asian species will inform approaches in which resistance genes can be introgressed into North American ash species. The generation of resistant North American ash genotypes can be used in forest ecosystem restoration and urban plantings following the wake of the emerald ash borer invasion.

  8. Benzylisoquinoline alkaloid metabolism: a century of discovery and a brave new world.

    Science.gov (United States)

    Hagel, Jillian M; Facchini, Peter J

    2013-05-01

    Benzylisoquinoline alkaloids (BIAs) are a structurally diverse group of plant specialized metabolites with a long history of investigation. Although the ecophysiological functions of most BIAs are unknown, the medicinal properties of many compounds have been exploited for centuries. These include the narcotic analgesics codeine and morphine, the antimicrobial agents sanguinarine and berberine, and the antitussive and anticancer drug noscapine. BIA biosynthesis involves a restricted number of enzyme types that catalyze landmark coupling reactions and subsequent functional group modifications. A pathogenesis-related (PR)10/Bet v1 'Pictet-Spenglerase', several O-methyl-, N-methyl- and O-acetyltransferases, cytochromes P450, FAD-dependent oxidases, non-heme dioxygenases and NADPH-dependent reductases have been implicated in the multistep pathways leading to structurally diverse alkaloids. A small number of plant species, including opium poppy (Papaver somniferum) and other members of the Ranunculales, have emerged as model systems to study BIA metabolism. The expansion of resources to include a wider range of plant species is creating an opportunity to investigate previously uncharacterized BIA pathways. Contemporary knowledge of BIA metabolism reflects over a century of research coupled with the development of key innovations such as radioactive tracing, enzyme isolation and molecular cloning, and functional genomics approaches such as virus-induced gene silencing. Recently, the emergence of transcriptomics, proteomics and metabolomics has expedited the discovery of new BIA biosynthetic genes. The growing repository of BIA biosynthetic genes is providing the parts required to apply emerging synthetic biology platforms to the development of production systems in microbes as an alternative to plants as a commecial source of valuable BIAs.

  9. Clinical observation of raltitrexed/bevacizumab combined with irinotecan or oxaliplation for advanced colorectal cancer

    Institute of Scientific and Technical Information of China (English)

    Jianwei Yang; Wei Gao; Jinyuan Lin; Yan Meng; Shuzhen Zhang; Tong Wang

    2014-01-01

    Objective: The aim of the study was to investigate the ef icacy and safety of raltitrexed/bevacizumab in combina-tion with irinotecan or oxaliplation for advanced colorectal cancer as the second-line and second-line above treatments. Meth-ods: Fifteen cases of advanced colorectal cancer were enrol ed to receive regimens including raltitrexed/bevacizumab com-bined with irinotecan or oxaliplation. Two cases were treated with raltitrexed + bavacizumab regimen, 9 cases with raltitrexed+ bavacizumab + irinotecan regimen, and 4 cases with raltitrexed + bevacizumab + oxaliplation regimen. The doses of the drugs were as fol ows: bevacizumab 5 mg/kg ivgtt, d1; raltitrexed 2.0 mg/m2 ivgtt 15 min, d2; irinotecan 180 mg/m2 ivgtt 1 h, d2; and oxaliplatin 85 mg/m2 ivgtt 2 h, d2. Two weeks was a cycle for each regimen. Results: The ef icacy of the 15 patients could be evaluated. Two cases were in PR ,10 cases in SD, 3 cases in PD, the response rate was 13.3%, and the disease control rate was 80.0%. The median progress-free survival was 5.1 months (95% CI: 3.404-6.813 months), and the median overal survival was 11.5 months (95% CI: 8.985-13.930 months). The adverse ef ects included anorexia, nausea/vomit-ing, fatigue, leucopenia, thrombocytopenia, etc, and the main 3-4 grades adverse ef ects were anorexia, nausea/vomiting, fatigue, and thrombocytopenia. Conclusion: Raltitrexed/bevacizumab combined with irinotecan or oxaliplatin as the second-line and second-line above treatments for advanced colorectal cancer has high disease control rates, and the adverse ef ect is wel tolerated. The combined regimen can be recommended as a phase III clinical research and second-line and second-lines above treatments for advanced colorectal cancer.

  10. Prospecting For Magnetite Ore Deposits With A Innovative Sensor's of Unique Fundamentally New Magnetometer.

    Science.gov (United States)

    Emelianenko, T. I.; Tachaytdinov, R. S.; Sarichev, V. F.; Kotov, B. V.; Susoeva, G. N.

    erosional truncation level determination(Patent for invention N 2148844 dated 10.05.2000,M.,2000). Emelianenko T.I.,Tachaytdinov R.S.,Sarichev V.F.,Kotov B.V.,Susoeva G.N.2000.Fundamentally new magnetometer -locator for search magnetite ores (Abstracts of 31 International Geological Congress -Rio-de-Janeiro Brasil)at http www:// 31.igc.org. Emel ianenko T.I.,Matveev A.A. 2000.New geochemical method of quantity estimation of magnetite deposits(Abstracts of 31 International Geological Congress in Rio de Janeiro Brasil)at htt :www.31.igc.org. Emelianenko T.I.,Matveev A.A.2001.Fundamentally new geochemical method of quantitative of magnetite ore deposits(Abstracts of 20 International Geochemical Exploration Simposium,Santiago de Chile)at http ://aeg.org. Emelianenko T.I.,Matveev A.A.2001.Fundamentally new geochemical method of hypsometrical level of magnetite deposits ore zone.(Abstracts of 20 International Geochemical Exploration Symposium Santiago de Chile).at http:www.aeg.org. Nikitskiye V.E.,Glebovskiye J.S..Magnitoprospecting.M.N.1980. Nikitskiye V.E.,Glebovskiye J.S. Magnitoprospecting.M.,N.,1990. .Grinevitch G.I.Magnitoprospecting.M.,N.,1974.

  11. Nephroprotective effect of estrogen and progesterone combination on cisplatin-induced nephrotoxicity in ovariectomized female rats

    Science.gov (United States)

    Ghasemi, M.; Nematbakhsh, M.; Pezeshki, Z.; Soltani, N.; Moeini, M.; Talebi, A.

    2016-01-01

    Recently, we reported that estrogen (Es) has no beneficial effect on cisplatin (CP)-induced nephrotoxicity, but the role of progesterone (Pr) and the combination of Es and Pr are not yet well-defined. In this study, we investigated the protective role of Pr, and co-administration of Es/Pr on CP-induced nephrotoxicity. Eighty-six ovariectomized female Wistar rats were divided into 13 groups, and the experiments were performed in two phases. In Phase I, Groups 1–4 received 2, 5, 10, and 25 mg/kg, IM Pr dissolved in sesame oil every 5 days for four doses. Groups 5–8 had the same treatment regimen as Groups 1–4, but after the third injection the animals also received continuous dose of CP (2.5 mg/kg/day, i.p.) for 8 days. Group 9, as the positive control group, received sesame oil instead of Pr plus CP. Group 10, as the negative control group, received sesame oil instead of Pr. After the most effective dose of Pr was determined in Phase I, Groups 11–13 in Phase II received 10 mg/kg Pr plus either 0.25, 0.5, or 1 mg/kg, IM estradiol valerate every 5 days for four doses. After the third injection, they also received a continuous dose of CP for 8 days. The levels of blood urea nitrogen (BUN) and creatinine (Cr), kidney tissue damage score (KTDS), and kidney weight (KW) increased and body weight (BW) decreased in the positive control group (P < 0.05). Administration of Pr (10 mg/kg) plus CP decreased KTDS and BW loss and KW. Co-administration of ES/Pr at specific doses improved Cr, BUN, and KTDS; and resulted in reduced CP-induced nephrotoxicity. The results obtained suggest that the beneficial effect of Pr on CP-induced nephrotoxicity is dose-dependent. In addition, combination of Es/Pr with a specific dose decreased CP-induced nephrotoxicity. PMID:27194830

  12. The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands

    Directory of Open Access Journals (Sweden)

    Breiteneder Heimo

    2008-10-01

    Full Text Available Abstract Background The major birch pollen allergen, Bet v 1, is a member of the ubiquitous PR-10 family of plant pathogenesis-related proteins. In recent years, a number of diverse plant proteins with low sequence similarity to Bet v 1 was identified. In addition, determination of the Bet v 1 structure revealed the existence of a large superfamily of structurally related proteins. In this study, we aimed to identify and classify all Bet v 1-related structures from the Protein Data Bank and all Bet v 1-related sequences from the Uniprot database. Results Structural comparisons of representative members of already known protein families structurally related to Bet v 1 with all entries of the Protein Data Bank yielded 47 structures with non-identical sequences. They were classified into eleven families, five of which were newly identified and not included in the Structural Classification of Proteins database release 1.71. The taxonomic distribution of these families extracted from the Pfam protein family database showed that members of the polyketide cyclase family and the activator of Hsp90 ATPase homologue 1 family were distributed among all three superkingdoms, while members of some bacterial families were confined to a small number of species. Comparison of ligand binding activities of Bet v 1-like superfamily members revealed that their functions were related to binding and metabolism of large, hydrophobic compounds such as lipids, hormones, and antibiotics. Phylogenetic relationships within the Bet v 1 family, defined as the group of proteins with significant sequence similarity to Bet v 1, were determined by aligning 264 Bet v 1-related sequences. A distance-based phylogenetic tree yielded a classification into 11 subfamilies, nine exclusively containing plant sequences and two subfamilies of bacterial proteins. Plant sequences included the pathogenesis-related proteins 10, the major latex proteins/ripening-related proteins subfamily, and

  13. Descobrindo a Doença de Parkinson: impacto para o parkinsoniano e seu familiar Descubriendo la Enfermedad de Parkinson: impacto para el parkinsoniano y su familiar Diagnosed with Parkinson's Diesease: impact on patients and family members

    Directory of Open Access Journals (Sweden)

    Fabiana Magalhães Navarro Peternella

    2009-02-01

    Full Text Available Estudo de natureza qualitativa, com o objetivo de compreender o impacto do diagnóstico de Parkinson para o individuo e família. Os dados foram coletados no período de Outubro a Dezembro de 2007, junto a 20 indivíduos residentes em Maringá - PR, sendo dez parkinsonianos e seu familiar mais próximo, por meio de entrevista semi-estruturada. Na análise dos dados emergiram dois temas: "Descobrindo-se portador de doença de Parkinson" e "Percalços e sentimentos após o diagnostico", os quais revelam que a falta de conhecimento sobre a doença ainda é muito grande e que a qualidade do primeiro contato com o diagnóstico é crucial na determinação e comportamento dos indivíduos frente à doença.Estudio de naturaleza cualitativa, desarrollado con el objetivo de comprender el impacto del diagnóstico de Parkinson para el individuo y familia. Los datos fueron recogidos en el período de Octubre a Diciembre de 2007, junto a 20 individuos residentes en Maringá - PR, siendo diez parkinsonianos y su familiar más próximo, por medio de entrevista semiestructurada. En el análisis de los datos emergieron dos temas: "Descubriéndose portador de enfermedad de Parkinson: una larga trayectoria" y "Percances y sentimientos después del diagnóstico", los cuales revelan que la falta de conocimiento sobre la enfermedad aún es muy grande en la población en general y que la calidad del primer contacto con el diagnóstico es crucial en la determinación y comportamiento de los individuos frente la enfermedad.This was a qualitative nature, developed with the objective of understanding the impact of a Parkinson's diagnosis on the individual and the family. Data were collected between October and December 2007, from 20 individuals residing in Maringá, PR - 10 Parkinson's patients and their closest family member - using semi-structured interviews. From the analysis of the data, two themes emerged: "Coming to terms as a Parkinson's patient: a long path" and

  14. Prevalence and Correlates of HIV Infection among Street Boys in Kisumu, Kenya.

    Directory of Open Access Journals (Sweden)

    Ariella Goldblatt

    Full Text Available Despite their perceived vulnerability to HIV, East African street youth have been neglected in HIV prevention research. We examined HIV seroprevalence and correlates of HIV infection in a sample of male street youth in Kisumu, Kenya.We enrolled a street-recruited sample of 13-21 year old street youth. Participants completed a survey followed by voluntary HIV counseling and testing. Survey items included demographics, homelessness history, survival activities, sexual behavior and substance use. We examined the relationship between predictor variables, markers of coercion and marginalization and HIV.The sample included 296 males. Survival activities included garbage picking (55%, helping market vendors (55%, begging (17%, and working as porters (46% or domestic workers (4%. Forty-nine percent of participants reported at least weekly use of alcohol and 32% marijuana. Forty-six percent of participants reported lifetime inhalation of glue and 8% fuel. Seventy-nine percent of participants reported lifetime vaginal sex, 6% reported lifetime insertive anal sex and 8% reported lifetime receptive anal sex. Twelve (4.1%; 95% CI: 2.3-7.0 participants tested positive for HIV. Of those, all had been on the street for at least one year and all had engaged in vaginal sex. Occupations placing youth at particular risk of coercion by adults, including helping market vendors (prevalence ratio (PR = 8.8; 95% CI: 1.2-67.5 and working as domestic workers (PR = 4.6; 95% CI: 1.1-19.0, were associated with HIV infection. Both insertive anal sex (PR = 10.2; 95% CI: 3.6-29.4 and receptive anal sex (PR = 3.9; 95% CI: 1.1-13.4 were associated with HIV infection. Drug use, begging, and garbage picking were not associated with HIV infection.Although HIV prevalence in our sample of street youth is comparable to that of similarly-aged male youth in Nyanza Province, our findings highlight behavioral factors associated with HIV infection that offer opportunities for targeted

  15. Clinical analysis of patients received pemetrexed therapy without the advised folic acid premedication%培美曲塞治疗未提前补充叶酸的晚期非小细胞肺癌35例

    Institute of Scientific and Technical Information of China (English)

    叶亮; 杨振华; 方苏榕; 谭焰; 谷伟

    2015-01-01

    Objective To explore whether 5 to -7-day of folic acid supplementation prior to pemetrexed therapy is needed. Methods We retrospectively evaluate the outcomes of non-small cell lung cancer patients received less than the advised folic acid premedication. Seventy patients with Ⅲ-Ⅳ NSCLC were randomly divided into two groups: patients who initiated vitamin supplementation on 7 days before the first dose of pemetrexed (group A) and patients who initiated vitamin supplementation on the day of the first dose of pemetrexed (group B). Results In group A and group B, CR 0 and 0, PR 10 and 8, the response rates of 28.6% and 22.9% were observed, respectively. There was no statistically significant differences between these two groups. No significant differences were observed in the incidence of hematologic and non-hematologic toxicities. Conclusions The initiation of pemetrexed-based chemotherapy does not need to accommodate a vitamin supplementation schedule.%目的:探讨培美曲塞化疗前是否需要提前5~7 d 补充叶酸预处理。方法:对比分析2010年1月至2013年12月就诊于南京市第一医院呼吸科接受培美曲塞治疗的晚期非鳞状非小细胞肺癌70例,根据培美曲塞首次化疗时补充叶酸时间分为提前补充叶酸组(35例)和未提前补充叶酸组(35例)。观察并分析两组患者化疗后不良反应及疗效的差异。结果:提前补充叶酸组无完全缓解(CR)病例,部分缓解(PR)22例,有效率为63%;非提前补充叶酸组无CR 病例,PR 23例,有效率为63%,两组患者有效率的比较差异无统计学意义。两组之间血液性及非血液性毒性差异亦无显著性。结论:培美曲塞首次化疗前可能不必提前1周进行补充叶酸治疗。

  16. SU-E-T-620: Planning and Dosimetry for Pulsed Low Dose Rate RT for Recurrent Lung, Spine, GYN and Head and Neck Cancers

    Energy Technology Data Exchange (ETDEWEB)

    Tong, X; Luo, F; Liu, Y; Zhang, W; Xu, Q; Zhang, T; Li, J [3rd Affiliated Hospital of Qiqihar Medical University, Qiqihar (China); Chen, L; Ma, C [Fox Chase Cancer Center, Philadelphia, PA (United States)

    2015-06-15

    Purpose: Extensive in vitro and in vivo studies have shown that pulsed low dose rate (PLDR) radiotherapy has potential to provide significant local tumor control and to reduce normal tissue toxicities. This work investigated the planning and dosimetry of PLDR re-irradiation for recurrent cancers. Methods: We analyzed the treatment plans and dosimetry for 13 recurrent patients who were treated with the PLDR technique in this study. All cases were planned with the 3DCRT technique with optimal beam angle selection. The treatment was performed on a Siemens accelerator using 6MV beams. The target volume ranged between 161 and 703cc. The previous RT dose was 40–60Gy while the re-irradiation dose was 16–60Gy. The interval between previous RT and re-irradiation was 13–336 months, and the follow-up time was up to 27months. The total prescription dose was administered in 2Gy/day fractions with the daily dose delivered in 10 sub-fractions (pulses) of 20cGy with a 3min interval between the pulses to achieve an effective dose rate of 6.7cGy/min. Results: The clinical outcome was analyzed based on the treatment plans. All pulses were kept with Dmax<40cGy. The PLDR treatments were effective (CR: 3 patients, PR: 10 patients). The acute and late toxicities were all acceptable (generally grade II or under). Two patients died three months after the PLDR re-irradiation, one due to massive cerebral infarction and the other due to acute cardiac failure. All others survived more than 8 months. Five patients showed good conditions at the last follow-up. Among them two recurrent lung cancer patients had survived 23 months and one nasopharyngeal cancer patient had survived 27 months. Conclusion: The PLDR technique was effective for the palliative treatment of head and neck, lung, spine and GYN cancers. Further phase II and III studies are warranted to quantify the efficacy of PLDR for recurrent cancers.

  17. Characterization of resistance to pine wood nematode infection in Pinus thunbergii using suppression subtractive hybridization

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    Hirao Tomonori

    2012-01-01

    Full Text Available Abstract Background Pine wilt disease is caused by the pine wood nematode, Bursaphelenchus xylophilus, which threatens pine forests and forest ecosystems worldwide and causes serious economic losses. In the 40 years since the pathogen was identified, the physiological changes occurring as the disease progresses have been characterized using anatomical and biochemical methods, and resistant trees have been selected via breeding programs. However, no studies have assessed the molecular genetics, e.g. transcriptional changes, associated with infection-induced physiological changes in resistant or susceptible trees. Results We constructed seven subtractive suppression hybridization (SSH cDNA libraries using time-course sampling of trees inoculated with pine wood nematode at 1, 3, or 7 days post-inoculation (dpi in susceptible trees and at 1, 3, 7, or 14 dpi in resistant trees. A total of 3,299 sequences was obtained from these cDNA libraries, including from 138 to 315 non-redundant sequences in susceptible SSH libraries and from 351 to 435 in resistant SSH libraries. Using Gene Ontology hierarchy, those non-redundant sequences were classified into 15 subcategories of the biological process Gene Ontology category and 17 subcategories of the molecular function category. The transcriptional components revealed by the Gene Ontology classification clearly differed between resistant and susceptible libraries. Some transcripts were discriminative: expression of antimicrobial peptide and putative pathogenesis-related genes (e.g., PR-1b, 2, 3, 4, 5, 6 was much higher in susceptible trees than in resistant trees at every time point, whereas expression of PR-9, PR-10, and cell wall-related genes (e.g., for hydroxyproline-rich glycoprotein precursor and extensin was higher in resistant trees than in susceptible trees at 7 and 14 dpi. Conclusions Following inoculation with pine wood nematode, there were marked differences between resistant and susceptible trees

  18. Clinical study of CAG regimen combined Decitabine in treatment of elderly patients with moderate and high risk myelodysplastic syndrome and acute myeloid leukemia%地西他滨联合小剂量化疗治疗老年中高危骨髓增生异常综合征及急性髓系白血病的临床观察

    Institute of Scientific and Technical Information of China (English)

    徐瑜; 沙颖豪; 谢彦晖

    2013-01-01

    Objective To observe the clinical efficacy and adverse events of treatment for elderly patients with moderate and high-risk myelodysplastic syndrome (MDS) and acute myelocytic leukemia (AMD with Decitabine (25mg/d, d1-3) combined with CAG (G-CSF300ug/d, d4-13; aclarubicin10mg/d, d4,6,8,10,12; Ara-C25mg/d, d4-13) regimen. Methods Decitabine combined with CAG regimen were used to treat 10 elderly patients with MDS and AML. The outcome was evaluated after 1 course of treatment. Results For ten patients, 3/10(30%) achieved completely remission (CR), 4/10 (40%) marrow completely remission (mCR), 1/10 (10%) partial remission (PR). The overall response rate was 80%. Most patients can withstand adverse reactions occurred mainly for the arrest of bone marrow. Conclusion In older patients, medium and high-risk MDS and AML treated with Decitabine combined with CAG regimen is safe and effective.%目的 观察地西他滨联合CAG方案治疗老年中高危MDS及AML的临床疗效及不良反应.方法 应用地西他滨联合CAG方案治疗MDS及AML患者10例.1个疗程后评估疗效.结果 10例患者,其中3例获得完全缓解(CR) 30%,4例为部分缓解(PR) 10%,1例获得骨髓缓解(mCR)40%.总有效率为80%.大多数患者出现了可以耐受的不良反应,主要表现为骨髓抑制.结论 地西他滨联合CAG方案治疗中高危MDS和老年AML有较好的疗效和安全性.

  19. The effect of high polyphenol oxidase grass silage on metabolism of polyunsaturated fatty acids and nitrogen across the rumen of beef steers.

    Science.gov (United States)

    Lee, M R F; Theobald, V J; Gordon, N; Leyland, M; Tweed, J K S; Fychan, R; Scollan, N D

    2014-11-01

    Polyphenol oxidase (PPO) activity in red clover (Trifolium pratense) has been reported to reduce both proteolysis and lipolysis, resulting in greater N use efficiency and protection of PUFA across the rumen. Although high levels of PPO have been reported in grasses such as cocksfoot (orchard grass; Dactylis glomerata), no in vivo research has determined whether grass PPO elicits the same response as red clover PPO. To test the hypothesis that silage ensiled from grass with high levels of PPO protects N and PUFA across the rumen, 6 steers with ruminal and duodenal cannulas were offered cocksfoot silage (CO; high-PPO grass), perennial ryegrass silage (PR; Lolium perenne; low-PPO grass), or red clover silage (RC; high-PPO control) at 16 g DM/kg BW daily with the experiment consisting of two 3 × 3 Latin squares with 21-d periods, consisting of 12 d of diet adaptation, 6 d of duodenal marker infusion, 2 d of duodenal sampling, and 1 d of ruminal sampling. All silages were well preserved, with DM of 34.4, 55.3, and 45.4% for CO, PR, and RC. Activity of PPO in silages was low due to deactivation but was greater in CO than either PR or RC (0.15 vs. 0.05 and 0.08 μkatal/g DM). Protein-bound phenol (mg/g DM) as a measure of the degree of oxidation and an indication of PPO protection was greatest for RC (15.9) but comparable for PR (10.1) and CO (12.2). Biohydrogenation of C18 PUFA was significantly lower on RC compared to the 2 grass silages with CO greater than PR. Despite lower levels of total fatty acid intake and subsequent duodenal flow, CO resulted in greater levels of phytanic acid and total branched and odd chain fatty acids in duodenal digesta than RC or PR. Ruminal ammonia concentration was greatest for RC, with no difference between the grasses. Duodenal flow of microbial N and efficiency of microbial protein synthesis were lowest for CO and comparable for RC and PR. The CO (high-grass PPO) did not result in elevated levels of C18 PUFA escaping the rumen or

  20. 奥沙利铂联合卡培他滨治疗晚期胃癌的21例临床探讨%Combination of oxaliplatin and capecitabine in treatment of twenty-one advanced gastric cancer

    Institute of Scientific and Technical Information of China (English)

    徐满珍; 李小兵

    2013-01-01

    Objective: To observe the efficacy and side efferts of oxalipatin plus capecitabine for the treatment of ad-vanced gastric cancer Methods: Twenty-one cases of patients . Oxaliplatin was given at a dose of 130mg/m2 by intravenous injection at day 1; Cape citabine was orally given at a dose of 2500 mg/m2, twice a day for two weeks. Twenty-one days was one cycle.Results: Among 21 patients , the response rate (CR+PR) was 57.1% with 2CR, 10PR, 3SD,6PD. MST was 9 months, mttp was 7 months. The major side effects were hand-foot syn-drome in 7(33.3%), newel toxity 12(57.1%), diarrhea 14 .conclusion: oxaplatin cornbined with capecitabine is a good chernother-appy with high clinical remission rate and could signiticartly improve life quality .And side effects could be tolerable.%目的观察奥沙利铂联合卡培他滨治疗晚期胃癌的疗效和安全性。方法21例晚期胃癌患者,静脉滴注奥沙利铂130mg/m2,d1;卡培他滨2500 mg/m2,分早晚2次口服,d1-14,21天为1周期。结果21例患者中,CR 2例,PR10例,SD3例,PD6例,近期有效率(CR+PR)为57.1%,中位生存期9个月,中位疾病进展时间为7个月。不良反应为手足综合征、神经毒性,多为Ⅰ-Ⅱ度。结论奥沙利铂联合卡培他滨化疗方案,缓解率高,能提高生活质量,毒副反应小,患者易耐受。