WorldWideScience

Sample records for advisor system amas

  1. Autonomus Mobility Applique System (AMAS) JCTD

    Science.gov (United States)

    2011-06-23

    Implementation Directive (ID) (60 Days after CDB) XXX RFP/Contract negotiations (RTC Contract 105 days) XXX Management Plan (60 Days After JCTD Start... XXX Develop CONOPS / TTP and finalize XXX Develop and update Design and Plans XXX Integrate & Deploy Software/Hardware Components XXX Install...Integrated System XXX Technical Demonstrations XXX ATEC Limited Safety Release and Assessment XXX Limited User Assessment XXX Operator Training XXX

  2. A Novel Web-based Human Advisor Fuzzy Expert System

    Directory of Open Access Journals (Sweden)

    Vahid Rafe

    2013-02-01

    Full Text Available The applications of the Internet-based technologies and the concepts of fuzzy expert systems (FES have created new methods for sharing and distributing knowledge. However, there has been a general lack of investigation in the area of web-based fuzzy expert systems. In this paper, the issues associated with the design, development, and use of web-based applications from a standpoint of the benefits and challenges of development and utilization are investigated. The original theory and concepts in conventional FES are reviewed and a knowledge engineering framework for developing such systems is revised. For a human advisor to have a satisfying performance, expertise is a must. In addition, some of advisory rules are subject to change because of domain knowledge update. The human requests may have linguistic or crisp forms and a conventional expert system (ES is not able to overcome the fuzziness in the problem nature. In this research, a Web-based fuzzy expert system for Common Human Advisor (FES-CHA is developed and implemented to be used as a student advisor at the department‘s web portal. The system is implemented by using Microsoft Visual Studio .NET 2010, MVC and Microsoft SQL Server 2012.

  3. A Novel Web-based Human Advisor Fuzzy Expert System

    Directory of Open Access Journals (Sweden)

    Vahid Rafe

    2013-01-01

    Full Text Available The applications of the Internet-based technologies and the concepts of fuzzy expert systems (FES have creatednew methods for sharing and distributing knowledge. However, there has been a general lack of investigation in thearea of web-based fuzzy expert systems. In this paper, the issues associated with the design, development, and useof web-based applications from a standpoint of the benefits and challenges of development and utilization areinvestigated. The original theory and concepts in conventional FES are reviewed and a knowledge engineeringframework for developing such systems is revised. For a human advisor to have a satisfying performance, expertise isa must. In addition, some of advisory rules are subject to change because of domain knowledge update. The humanrequests may have linguistic or crisp forms and a conventional expert system (ES is not able to overcome thefuzziness in the problem nature. In this research, a Web-based fuzzy expert system for Common Human Advisor(FES-CHA is developed and implemented to be used as a student advisor at the department's web portal. Thesystem is implemented by using Microsoft Visual Studio .NET 2010, MVC and Microsoft SQL Server 2012.

  4. System Advisor Model: Flat Plate Photovoltaic Performance Modeling Validation Report

    Energy Technology Data Exchange (ETDEWEB)

    Freeman, J.; Whitmore, J.; Kaffine, L.; Blair, N.; Dobos, A. P.

    2013-12-01

    The System Advisor Model (SAM) is a free software tool that performs detailed analysis of both system performance and system financing for a variety of renewable energy technologies. This report provides detailed validation of the SAM flat plate photovoltaic performance model by comparing SAM-modeled PV system generation data to actual measured production data for nine PV systems ranging from 75 kW to greater than 25 MW in size. The results show strong agreement between SAM predictions and field data, with annualized prediction error below 3% for all fixed tilt cases and below 8% for all one axis tracked cases. The analysis concludes that snow cover and system outages are the primary sources of disagreement, and other deviations resulting from seasonal biases in the irradiation models and one axis tracking issues are discussed in detail.

  5. Comparison of Photovoltaic Models in the System Advisor Model: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Blair, N. J.; Dobos, A. P.; Gilman, P.

    2013-08-01

    The System Advisor Model (SAM) is free software developed by the National Renewable Energy Laboratory (NREL) for predicting the performance of renewable energy systems and analyzing the financial feasibility of residential, commercial, and utility-scale grid-connected projects. SAM offers several options for predicting the performance of photovoltaic (PV) systems. The model requires that the analyst choose from three PV system models, and depending on that choice, possibly choose from three module and two inverter component models. To obtain meaningful results from SAM, the analyst must be aware of the differences between the model options and their applicability to different modeling scenarios. This paper presents an overview the different PV model options and presents a comparison of results for a 200-kW system using different model options.

  6. CRITERIA FOR CONSULTANT AND ADVISOR IN THE BRAZILIAN POSTGRADUATE SYSTEM.

    Science.gov (United States)

    Petroianu, Andy

    2015-01-01

    To review the rules, resolutions and existing documents relating to consultant and advisor to better target the actions of those who exercise these roles. The following documents were consulted: Statute of CAPES, through Decree No. 7692 of March 2, 2012; Ordinance No. 47 of 17/10/1995; Opinion 977 1965 Newton Sucupira; Area Document of Medicine III; Interministerial Ordinance 251 of 2012, based on Decree No. 7642 of 2011 of the Ministry of Science and Technology; CAPES Regiment. The Brazilian Postgraduate system is divided in two different fields, according to its aspects: the "lato sensu" postgraduate, defined as all professional studies performed after the high school graduation; and the "stricto sensu" postgraduate that includes the master degree and the doctorate, both of them different from what is known as MSc or MS and PhD. The Brazilian doctorate is recognized as academic because its purposes include to improve the scientific and the teaching levels of university docents. The master degree has two different objectives one is to be academic and similar to the doctorate; the other is to upgrade professionals to a higher level than specialist or MBA and is denominated professional master degree. The master degrees and the doctorate are designated as courses and may be put together in a structure known as stricto sensu postgraduate program. The complexity of these courses and programs in all the areas of the superior human knowledge requires a large number of professional directly involved with this system and other professionals that attend them, called consultants and advisors. The consultants are counselors, and the advisors are assistants, both of them legally established with the incumbency to aid the postgraduate staff in all their duties. Nothing prevents a person from being a consultant on the situation and advisor on another, even in the same institution. Have knowledge about what being a consultant and advisor is required to exercise the function

  7. The CBT Advisor: An Expert System Program for Making Decisions about CBT.

    Science.gov (United States)

    Kearsley, Greg

    1985-01-01

    Discusses structure, credibility, and use of the Computer Based Training (CBT) Advisor, an expert system designed to help managers make judgements about course selection, system selection, cost/benefits, development effort, and probable success of CBT projects. (MBR)

  8. System Advisor Model, SAM 2011.12.2: General Description

    Energy Technology Data Exchange (ETDEWEB)

    Gilman, P.; Dobos, A.

    2012-02-01

    This document describes the capabilities of the U.S. Department of Energy and National Renewable Energy Laboratory's System Advisor Model (SAM), Version 2011.12.2, released on December 2, 2011. SAM is software that models the cost and performance of renewable energy systems. Project developers, policy makers, equipment manufacturers, and researchers use graphs and tables of SAM results in the process of evaluating financial, technology, and incentive options for renewable energy projects. SAM simulates the performance of solar, wind, geothermal, biomass, and conventional power systems. The financial model can represent financing structures for projects that either buy and sell electricity at retail rates (residential and commercial) or sell electricity at a price determined in a power purchase agreement (utility). Advanced analysis options facilitate parametric, sensitivity, and statistical analyses, and allow for interfacing SAM with Microsoft Excel or with other computer programs. SAM is available as a free download at http://sam.nrel.gov. Technical support and more information about the software are available on the website.

  9. System Advisor Model, SAM 2014.1.14: General Description

    Energy Technology Data Exchange (ETDEWEB)

    Blair, N.; Dobos, A. P.; Freeman, J.; Neises, T.; Wagner, M.; Ferguson, T.; Gilman, P.; Janzou, S.

    2014-02-01

    This document describes the capabilities of the U.S. Department of Energy and National Renewable Energy Laboratory's System Advisor Model (SAM), Version 2013.9.20, released on September 9, 2013. SAM is a computer model that calculates performance and financial metrics of renewable energy systems. Project developers, policy makers, equipment manufacturers, and researchers use graphs and tables of SAM results in the process of evaluating financial, technology, and incentive options for renewable energy projects. SAM simulates the performance of photovoltaic, concentrating solar power, solar water heating, wind, geothermal, biomass, and conventional power systems. The financial model can represent financial structures for projects that either buy and sell electricity at retail rates (residential and commercial) or sell electricity at a price determined in a power purchase agreement (utility). SAM's advanced simulation options facilitate parametric and sensitivity analyses, and statistical analysis capabilities are available for Monte Carlo simulation and weather variability (P50/P90) studies. SAM can also read input variables from Microsoft Excel worksheets. For software developers, the SAM software development kit (SDK) makes it possible to use SAM simulation modules in their applications written in C/C++, C#, Java, Python, and MATLAB. NREL provides both SAM and the SDK as free downloads at http://sam.nrel.gov. Technical support and more information about the software are available on the website.

  10. Autopsy on the AMA: An Analysis of Healthcare Delivery Systems in America [1970

    Directory of Open Access Journals (Sweden)

    Joe Woodard

    2009-02-01

    Full Text Available Prepared by: Cy Schoenfield, Janet Brown, Joe Woodard, Jeff Brown, Martin Brown, Charles Turner, Jill Hill Published in 1970 by Student Research Facility, Berkeley, California Reproduced from the US Heath Activism History Collection Rare Book and Manuscript Library, University of Pennsylvania "The United States (has a quality of medical care unsurpassed anywhere," said Dr. Milford O. Rouse, President of the American Medical Association (the AMA in 1967. His position at the pinnacle of the most powerful country's most powerful medical organization certainly gave him the authority to say that with confidence. "People respect doctors. In fact, 92% of the public feels most doctors can be trusted. People in the medical therapy professions are admired and the communities they serve reward them well for their work. Doctors averaged $31,400 a year in 1967 and their median income was $32,170 in 1968. These figures are approximately five times the average and median incomes for the general population. "Medically speaking, things seem to be going well. The drama of headlines about organ transplants and new medical advances in the laboratory also serve to indicate that the System that provides health care for Americans does its job splendidly. But does it, really?"

  11. Phase 1/2a study of the malaria vaccine candidate apical membrane antigen-1 (AMA-1 administered in adjuvant system AS01B or AS02A.

    Directory of Open Access Journals (Sweden)

    Michele D Spring

    Full Text Available BACKGROUND: This Phase 1/2a study evaluated the safety, immunogenicity, and efficacy of an experimental malaria vaccine comprised of the recombinant Plasmodium falciparum protein apical membrane antigen-1 (AMA-1 representing the 3D7 allele formulated with either the AS01B or AS02A Adjuvant Systems. METHODOLOGY/PRINCIPAL FINDINGS: After a preliminary safety evaluation of low dose AMA-1/AS01B (10 microg/0.5 mL in 5 adults, 30 malaria-naïve adults were randomly allocated to receive full dose (50 microg/0.5 mL of AMA-1/AS01B (n = 15 or AMA-1/AS02A (n = 15, followed by a malaria challenge. All vaccinations were administered intramuscularly on a 0-, 1-, 2-month schedule. All volunteers experienced transient injection site erythema, swelling and pain. Two weeks post-third vaccination, anti-AMA-1 Geometric Mean Antibody Concentrations (GMCs with 95% Confidence Intervals (CIs were high: low dose AMA-1/AS01B 196 microg/mL (103-371 microg/mL, full dose AMA-1/AS01B 279 microg/mL (210-369 microg/mL and full dose AMA-1/AS02A 216 microg/mL (169-276 microg/mL with no significant difference among the 3 groups. The three vaccine formulations elicited equivalent functional antibody responses, as measured by growth inhibition assay (GIA, against homologous but not against heterologous (FVO parasites as well as demonstrable interferon-gamma (IFN-gamma responses. To assess efficacy, volunteers were challenged with P. falciparum-infected mosquitoes, and all became parasitemic, with no significant difference in the prepatent period by either light microscopy or quantitative polymerase chain reaction (qPCR. However, a small but significant reduction of parasitemia in the AMA-1/AS02A group was seen with a statistical model employing qPCR measurements. SIGNIFICANCE: All three vaccine formulations were found to be safe and highly immunogenic. These immune responses did not translate into significant vaccine efficacy in malaria-naïve adults employing a primary sporozoite

  12. AmaXhosa beadwork ( Iintsimbi ) for identity affirmation and ...

    African Journals Online (AJOL)

    AmaXhosa beadwork ( Iintsimbi ) for identity affirmation and economic empowerment. ... However, modernity and western-based education relegated amaXhosa ... Given that schools are social systems for building children's character, they ...

  13. Characteristics of and Challenges for Advisors within a Privatized Extension System

    Science.gov (United States)

    Knuth, Ulrike; Knierim, Andrea

    2013-01-01

    Purpose: The aim of this article is to provide evidence on the consequences of the privatization process in Brandenburg with a focus on the agricultural advisors' situation. Before the background of future European Union (EU) expectations on Farm Advisory Systems (FAS), their capacities and competences to respond to such challenges are discussed.…

  14. Building knowledge systems for sustainable agriculture: supporting private advisors to adequately address sustainable farm management in regular service contacts

    NARCIS (Netherlands)

    Klerkx, L.W.A.; Jansen, J.

    2010-01-01

    Advisory service provisioning on sustainability issues such as environmental care and food safety is considered suboptimal in privatized extension systems, which comprise a diverse set of private advisors. Apart from funding dedicated ‘public good’ projects, government also relies on these advisors

  15. AMAS Robotics Seminar Brief

    Science.gov (United States)

    2011-07-19

    Unclassified Unclassified 19 July 2011 AMAS ROBOTICS SEMINAR BRIEF Aaron Hart, Product Integrator, RS JPO DISTRIBUTION STATEMENT A. Approved for...19-07-2011 to 19-07-2011 4. TITLE AND SUBTITLE robotics seminar brief 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6...12. DISTRIBUTION/AVAILABILITY STATEMENT Approved for public release; distribution unlimited 13. SUPPLEMENTARY NOTES AMAS ROBOTICS SEMINAR BRIEF 14

  16. In TripAdvisor we trust: Rankings, calculative regimes and systems trust

    OpenAIRE

    Jeacle, I.; Carter, Chris

    2011-01-01

    A proliferation of rankings and league tables increasingly permeate everyday life. An objective of this paper is to explain the profusion of such rankings, in particular on-line user review rankings, in contemporary society and what this means for our understanding of the role of accounting. The online travel website TripAdvisor and its hotel ranking system is a prominent example of this new phenomenon. The site increasingly appears to play the role of trusted intermediary for the ‘independen...

  17. NREL's System Advisor Model Simplifies Complex Energy Analysis (Fact Sheet)

    Energy Technology Data Exchange (ETDEWEB)

    2015-01-01

    NREL has developed a tool -- the System Advisor Model (SAM) -- that can help decision makers analyze cost, performance, and financing of any size grid-connected solar, wind, or geothermal power project. Manufacturers, engineering and consulting firms, research and development firms, utilities, developers, venture capital firms, and international organizations use SAM for end-to-end analysis that helps determine whether and how to make investments in renewable energy projects.

  18. P50/P90 Analysis for Solar Energy Systems Using the System Advisor Model: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Dobos, A. P.; Gilman, P.; Kasberg, M.

    2012-06-01

    To secure competitive financing for a solar energy generation project, the economic risk associated with interannual solar resource variability must be quantified. One way to quantify this risk is to calculate exceedance probabilities representing the amount of energy expected to be produced by a plant. Many years of solar radiation and metereological data are required to determine these values, often called P50 or P90 values for the level of certainty they represent. This paper describes the two methods implemented in the National Renewable Energy Laboratory's System Advisor Model (SAM) to calculate P50 and P90 exceedance probabilities for solar energy projects. The methodology and supporting data sets are applicable to photovoltaic, solar water heating, and concentrating solar power (CSP) systems.

  19. Expert Maintenance Advisor Development for Navy Shipboard Systems

    Science.gov (United States)

    1994-01-01

    for Supervisory Process Control ," Xavier Alaman, Instituto de Ingenieria del Conocimiento, SPAIN - (L) INTEGRATED KNOWLEDGE BASED SYSTEMS IN POWER...Estoril (EDEN) Chair: Xavier Alaman, Instituto de Ingenieria del Conocimiento, SPAIN "A Model of Handling Uncertainty in Expert Systems," 01 Zhao...ain power switch A3P20s1 to OrF. On the control mount subasebly ?3A20. eat/verity the followinq: (1H igqh sped selecat switch - 7.5 (2) LoA speed

  20. Development of the Expert System Domain Advisor and Analysis Tool

    Science.gov (United States)

    1991-09-01

    analysis. Typical of the current methods in use at this time is the " tarot metric". This method defines a decision rule whose output is whether to go...B - TAROT METRIC B. ::TTRODUCTION The system chart of ESEM, Figure 1, shows the following three risk-based decision points: i. At prolect initiation...34 decisions. B-I 201 PRELIMINARY T" B-I. Evaluais Factan for ES Deyelopsineg FACTORS POSSIBLE VALUE RATINGS TAROT metric (overall suitability) Poor, Fair

  1. An intelligent, knowledge-based multiple criteria decision making advisor for systems design

    Science.gov (United States)

    Li, Yongchang

    of an appropriate decision making method. Furthermore, some DMs may be exclusively using one or two specific methods which they are familiar with or trust and not realizing that they may be inappropriate to handle certain classes of the problems, thus yielding erroneous results. These issues reveal that in order to ensure a good decision a suitable decision method should be chosen before the decision making process proceeds. The first part of this dissertation proposes an MCDM process supported by an intelligent, knowledge-based advisor system referred to as Multi-Criteria Interactive Decision-Making Advisor and Synthesis process (MIDAS), which is able to facilitate the selection of the most appropriate decision making method and which provides insight to the user for fulfilling different preferences. The second part of this dissertation presents an autonomous decision making advisor which is capable of dealing with ever-evolving real time information and making autonomous decisions under uncertain conditions. The advisor encompasses a Markov Decision Process (MDP) formulation which takes uncertainty into account when determines the best action for each system state. (Abstract shortened by UMI.)

  2. Validation of PV-RPM Code in the System Advisor Model.

    Energy Technology Data Exchange (ETDEWEB)

    Klise, Geoffrey Taylor [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Lavrova, Olga [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Freeman, Janine [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2017-04-01

    This paper describes efforts made by Sandia National Laboratories (SNL) and the National Renewable Energy Laboratory (NREL) to validate the SNL developed PV Reliability Performance Model (PV - RPM) algorithm as implemented in the NREL System Advisor Model (SAM). The PV - RPM model is a library of functions that estimates component failure and repair in a photovoltaic system over a desired simulation period. The failure and repair distributions in this paper are probabilistic representations of component failure and repair based on data collected by SNL for a PV power plant operating in Arizona. The validation effort focuses on whether the failure and repair dist ributions used in the SAM implementation result in estimated failures that match the expected failures developed in the proof - of - concept implementation. Results indicate that the SAM implementation of PV - RPM provides the same results as the proof - of - concep t implementation, indicating the algorithms were reproduced successfully.

  3. Reference Manual for the System Advisor Model's Wind Power Performance Model

    Energy Technology Data Exchange (ETDEWEB)

    Freeman, J.; Jorgenson, J.; Gilman, P.; Ferguson, T.

    2014-08-01

    This manual describes the National Renewable Energy Laboratory's System Advisor Model (SAM) wind power performance model. The model calculates the hourly electrical output of a single wind turbine or of a wind farm. The wind power performance model requires information about the wind resource, wind turbine specifications, wind farm layout (if applicable), and costs. In SAM, the performance model can be coupled to one of the financial models to calculate economic metrics for residential, commercial, or utility-scale wind projects. This manual describes the algorithms used by the wind power performance model, which is available in the SAM user interface and as part of the SAM Simulation Core (SSC) library, and is intended to supplement the user documentation that comes with the software.

  4. Youth Advisors Driving Action: hearing the youth voice in mental health systems of care.

    Science.gov (United States)

    Davis-Brown, Karen; Carter, Naeemah; Miller, Bethany D

    2012-03-01

    The Children's Mental Health Initiative (CMHI) is funded by the Center for Mental Health Services within the Substance Abuse and Mental Health Services Administration. CMHI assists communities in developing comprehensive, coordinated services for children with serious emotional disturbances and their families. Broadly speaking, these systems are designed to be child centered, youth guided, family driven, community based, and culturally competent. To assure implementation of the "youth-guided" core value in the national evaluation, an advisory group of youth coordinator/youth teams representing communities across the country was developed. This group chose the name YADA-Youth Advisors Driving Action. YADA has made a substantive contribution to national evaluation efforts by bringing the youth perspective and voice to its audience at the community and national levels. This article describes YADA's founding and development, as well as related implications for psychosocial nurses.

  5. “班主任制”缘起——俄国班主任制要义%The Origin of Class -advisor System: the Essential of Russia' s Class - advisor System

    Institute of Scientific and Technical Information of China (English)

    陈桂生

    2011-01-01

    In view of the common facts that our class - advisors muddled with their work, it' s necessary to trace the origin of class - advisor system and analyze the difference between China' s and Russia' s class - advisor system, which helps to reveal the crux from the perspective of education.%鉴于我国多年来班主任工作忙乱现象相当普遍,追溯班主任制缘起,分析中俄班主任制的区别,以便从教育专业的角度,揭示班主任制问题的症结。

  6. Direct-Steam Linear Fresnel Performance Model for NREL's System Advisor Model

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, M. J.; Zhu, G.

    2012-09-01

    This paper presents the technical formulation and demonstrated model performance results of a new direct-steam-generation (DSG) model in NREL's System Advisor Model (SAM). The model predicts the annual electricity production of a wide range of system configurations within the DSG Linear Fresnel technology by modeling hourly performance of the plant in detail. The quasi-steady-state formulation allows users to investigate energy and mass flows, operating temperatures, and pressure drops for geometries and solar field configurations of interest. The model includes tools for heat loss calculation using either empirical polynomial heat loss curves as a function of steam temperature, ambient temperature, and wind velocity, or a detailed evacuated tube receiver heat loss model. Thermal losses are evaluated using a computationally efficient nodal approach, where the solar field and headers are discretized into multiple nodes where heat losses, thermal inertia, steam conditions (including pressure, temperature, enthalpy, etc.) are individually evaluated during each time step of the simulation. This paper discusses the mathematical formulation for the solar field model and describes how the solar field is integrated with the other subsystem models, including the power cycle and optional auxiliary fossil system. Model results are also presented to demonstrate plant behavior in the various operating modes.

  7. Molten Salt Power Tower Cost Model for the System Advisor Model (SAM)

    Energy Technology Data Exchange (ETDEWEB)

    Turchi, C. S.; Heath, G. A.

    2013-02-01

    This report describes a component-based cost model developed for molten-salt power tower solar power plants. The cost model was developed by the National Renewable Energy Laboratory (NREL), using data from several prior studies, including a contracted analysis from WorleyParsons Group, which is included herein as an Appendix. The WorleyParsons' analysis also estimated material composition and mass for the plant to facilitate a life cycle analysis of the molten salt power tower technology. Details of the life cycle assessment have been published elsewhere. The cost model provides a reference plant that interfaces with NREL's System Advisor Model or SAM. The reference plant assumes a nominal 100-MWe (net) power tower running with a nitrate salt heat transfer fluid (HTF). Thermal energy storage is provided by direct storage of the HTF in a two-tank system. The design assumes dry-cooling. The model includes a spreadsheet that interfaces with SAM via the Excel Exchange option in SAM. The spreadsheet allows users to estimate the costs of different-size plants and to take into account changes in commodity prices. This report and the accompanying Excel spreadsheet can be downloaded at https://sam.nrel.gov/cost.

  8. A New Supercapacitor and Li-ion Battery Hybrid System for Electric Vehicle in ADVISOR

    Science.gov (United States)

    Peng, Xiao; Shuhai, Quan; Changjun, Xie

    2017-02-01

    The supercapacitor (SC) and Li-ion battery(BT) hybrid energy storage system(HESS) electric vehicle(EV) is gaining universal attention. The topology is of importance for the SC/BT HESS. A new SC/BT topology HESS with a rule-based energy management strategy for EV was proposed. The BT pack is connected directly to the DC link via a controlled switch. The SC pack is connected to the DC link via a controlled switch. A uni-directional DC/DC converter is connected between the SC pack and the BT pack. The braking regeneration energy is all harvested by the SC pack. The output power of BT pack is limited. The different SC/BT configurations with varied BT maximum Ah capacity factor and SC maximum capacity factor are simulated in ADVISOR. Simulation results show that BT maximum Ah capacity factor has little impact on vehicle acceleration performance and maximum speed. SC maximum capacity factor has significant impact on vehicle acceleration performance and maximum speed. The fuel economy isn’t affected.

  9. Toelating en opvang van ama's

    NARCIS (Netherlands)

    Bedem, R.F.A. van den; Valk, H.A.G. de; Tan, S.O.

    1994-01-01

    Sinds enige jaren komt een toenemend aantal minderjarige asielzoekers zonder hun wettelijke vertegenwoordigers naar Europa. Om een aantal redenen is speciale aandacht nodig voor deze 'alleenkomende minderjarige asielzoekers' (ama's). Omdat zij minderjarig en dus handelingsonbekwaam zijn, dient in de

  10. Parabolic Trough Collector Cost Update for the System Advisor Model (SAM)

    Energy Technology Data Exchange (ETDEWEB)

    Kurup, Parthiv [National Renewable Energy Lab. (NREL), Golden, CO (United States); Turchi, Craig S. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2015-11-01

    This report updates the baseline cost for parabolic trough solar fields in the United States within NREL's System Advisor Model (SAM). SAM, available at no cost at https://sam.nrel.gov/, is a performance and financial model designed to facilitate decision making for people involved in the renewable energy industry. SAM is the primary tool used by NREL and the U.S. Department of Energy (DOE) for estimating the performance and cost of concentrating solar power (CSP) technologies and projects. The study performed a bottom-up build and cost estimate for two state-of-the-art parabolic trough designs -- the SkyTrough and the Ultimate Trough. The SkyTrough analysis estimated the potential installed cost for a solar field of 1500 SCAs as $170/m2 +/- $6/m2. The investigation found that SkyTrough installed costs were sensitive to factors such as raw aluminum alloy cost and production volume. For example, in the case of the SkyTrough, the installed cost would rise to nearly $210/m2 if the aluminum alloy cost was $1.70/lb instead of $1.03/lb. Accordingly, one must be aware of fluctuations in the relevant commodities markets to track system cost over time. The estimated installed cost for the Ultimate Trough was only slightly higher at $178/m2, which includes an assembly facility of $11.6 million amortized over the required production volume. Considering the size and overall cost of a 700 SCA Ultimate Trough solar field, two parallel production lines in a fully covered assembly facility, each with the specific torque box, module and mirror jigs, would be justified for a full CSP plant.

  11. Modeling Photovoltaic Module-Level Power Electronics in the System Advisor Model; NREL (National Renewable Energy Laboratory)

    Energy Technology Data Exchange (ETDEWEB)

    None

    2015-07-01

    Module-level power electronics, such as DC power optimizers, microinverters, and those found in AC modules, are increasing in popularity in smaller-scale photovoltaic (PV) systems as their prices continue to decline. Therefore, it is important to provide PV modelers with guidelines about how to model these distributed power electronics appropriately in PV modeling software. This paper extends the work completed at NREL that provided recommendations to model the performance of distributed power electronics in NREL’s popular PVWatts calculator [1], to provide similar guidelines for modeling these technologies in NREL's more complex System Advisor Model (SAM). Module-level power electronics - such as DC power optimizers, microinverters, and those found in AC modules-- are increasing in popularity in smaller-scale photovoltaic (PV) systems as their prices continue to decline. Therefore, it is important to provide PV modelers with guidelines about how to model these distributed power electronics appropriately in PV modeling software.

  12. Simulating Study on Drive System Performance for Hybrid Electric Bus Based on ADVISOR

    Directory of Open Access Journals (Sweden)

    Wang Xingxing

    2017-01-01

    Full Text Available Hybrid electric bus has a number of advantages when compared with ordinary passenger cars, but in the dynamic matching and the vehicle performance are difficult to detect, thus limits its development process. In this paper, combined with the actual models, the hybrid electric bus module parameters were modified in the software of ADVISOR (Advanced Vehicle Simulator, main including: module of the vehicle, the wheel module, motor module, a battery module and engine module, three kinds of bus models for A, B and C were established, and the related performance that need to be analyzed was set up, such as acceleration, gradability, emissions and energy utilization and so on, in order to ensure the vehicle running in the same environment and convenient for comparison, a fixed vehicle driving cycles was chose, then the simulation results was analyzed, and the various performance was compared with the dynamic indicators and economic indicators which determined by referencing of traditional city bus standard and each other, and finally, the performance optimal model of B was chose out which can meet the demand, its related performance parameters of the simulation results are as follows: the best gradability is 26%, maximum speed is 72.7km/h, maximum acceleration is 1.7m/s2, 0~50km/h acceleration time is 9.5s and fuel consumption is 25L/km.

  13. Phase 1/2a Study of the Malaria Vaccine Candidate Apical Membrane Antigen-1 (AMA-1) Administered in Adjuvant System AS01B or AS02A

    Science.gov (United States)

    2009-04-01

    International Conference on Harmonisation (ICH) guidelines and confirmed the vaccine antigen was stable and potent from date of manufacture through...Maryland, United States of America, 8 Malaria Vaccine Development Program, United States Agency for International Development, Washington D. C., United...into a multi-stage, multi-component vaccine [22]. First, an AMA-1 vaccine must confer significant clinical benefit in either a Phase 2a malaria

  14. Construction and indentification the Neospora caninum AMA1 bait vector in yeast two-hybrid system%牛源犬新孢子虫NcAMA1基因酵母双杂交诱饵载体构建及鉴定

    Institute of Scientific and Technical Information of China (English)

    李积旭; 张守发; 李男礼; 贾立军

    2016-01-01

    为筛选牛源犬新孢子虫AMA1与虫体互作的靶蛋白,构建NcAMA1基因酵母双杂交诱饵载体pGBKT7-AMA1.本试验应用RT-PCR技术从虫体总RNA中扩增了去除跨膜螺旋的AMA1基因,定向克隆到酵母双杂交诱饵载体pGBKT7中,将重组诱饵载体转化酵母Y2H,并验证其在酵母细胞中毒性作用和有无自激活现象.结果显示:本试验成功构建了诱饵载体pGBKT7-AMA1,并证明其对酵母细胞无毒性,且对报告基因无自激活.结果表明:诱饵载体pGBKT7-AMA1可用于酵母双杂交系统筛选与虫体互作的宿主蛋白.

  15. AMA Physician Select: Online Doctor Finder

    Science.gov (United States)

    ... Membership | JAMA Network | AMA Store DoctorFinder This online physician Locator helps you find a perfect match for ... with basic professional information on virtually every licensed physician in the United States. This includes more than ...

  16. UFC advisor: An AI-based system for the automatic test environment

    Science.gov (United States)

    Lincoln, David T.; Fink, Pamela K.

    1990-01-01

    The Air Logistics Command within the Air Force is responsible for maintaining a wide variety of aircraft fleets and weapon systems. To maintain these fleets and systems requires specialized test equipment that provides data concerning the behavior of a particular device. The test equipment is used to 'poke and prod' the device to determine its functionality. The data represent voltages, pressures, torques, temperatures, etc. and are called testpoints. These testpoints can be defined numerically as being in or out of limits/tolerance. Some test equipment is termed 'automatic' because it is computer-controlled. Due to the fact that effective maintenance in the test arena requires a significant amount of expertise, it is an ideal area for the application of knowledge-based system technology. Such a system would take testpoint data, identify values out-of-limits, and determine potential underlying problems based on what is out-of-limits and how far. This paper discusses the application of this technology to a device called the Unified Fuel Control (UFC) which is maintained in this manner.

  17. Peer review presentation on systems performance modeling and solar advisor support.

    Energy Technology Data Exchange (ETDEWEB)

    Cameron, Christopher P.

    2010-05-01

    Accurate Performance Models are Critical to Project Development and Technology Evaluation - Accuracy and Uncertainty of Commonly-Used Models Unknown and Models Disagree. A Model Evaluation Process Has Been Developed with Industry, and High-Quality Weather and System Performance Data Sets Have Been Collected: (1) Evaluation is Underway using Residual Analysis of Hourly and Sub-Hourly Data for Clear and Diffuse Climates to Evaluate and Improve Models; and (2) Initial Results Have Been or Will Soon Be Presented at Key Conferences. Evaluation of Widely-Used Module, Inverter, and Irradiance Models, Including Those in SAM, PVWatts, and PVSyst, Will Be Completed This Year. Stochastic Modeling Has Been Performed to Support Reliability Task and Will Add Value to Parametric Analysis. An Industry Workshop will be Held This Fall To Review Results, Set Priorities. Support and Analysis has been Provided for TPP's, SETP, and PV Community. Goals for Future Work Include: (1) Improving Understanding of and Validating System Derate Factors; and (2) Developing a Dynamic Electrical Model of Arrays with Shaded or Mismatched Modules to Support Transient Analysis of Large Fields.

  18. Training Public Health Advisors.

    Science.gov (United States)

    Meyer, Pamela A; Brusuelas, Kristin M; Baden, Daniel J; Duncan, Heather L

    2015-01-01

    Federal public health advisors provide guidance and assistance to health departments to improve public health program work. The Centers for Disease Control and Prevention (CDC) prepares them with specialized training in administering public health programs. This article describes the evolving training and is based on internal CDC documents and interviews. The first federal public health advisors worked in health departments to assist with controlling syphilis after World War II. Over time, more CDC prevention programs hired them. To meet emerging needs, 3 major changes occurred: the Public Health Prevention Service, a fellowship program, in 1999; the Public Health Associate Program in 2007; and integration of those programs. Key components of the updated training are competency-based training, field experience, supervision, recruitment and retention, and stakeholder support. The enduring strength of the training has been the experience in a public health agency developing practical skills for program implementation and management.

  19. Phase 1 trial of AMA1-C1/Alhydrogel plus CPG 7909: an asexual blood-stage vaccine for Plasmodium falciparum malaria.

    Directory of Open Access Journals (Sweden)

    Gregory E D Mullen

    Full Text Available BACKGROUND: Apical Membrane Antigen 1 (AMA1, a polymorphic merozoite surface protein, is a leading blood-stage malaria vaccine candidate. This is the first reported use in humans of an investigational vaccine, AMA1-C1/Alhydrogel, with the novel adjuvant CPG 7909. METHODS: A phase 1 trial was conducted at the University of Rochester with 75 malaria-naive volunteers to assess the safety and immunogenicity of the AMA1-C1/Alhydrogel+CPG 7909 malaria vaccine. Participants were sequentially enrolled and randomized within dose escalating cohorts to receive three vaccinations on days 0, 28 and 56 of either 20 microg of AMA1-C1/Alhydrogel+564 microg CPG 7909 (n = 15, 80 microg of AMA1-C1/Alhydrogel (n = 30, or 80 microg of AMA1-C1/Alhydrogel+564 microg CPG 7909 (n = 30. RESULTS: Local and systemic adverse events were significantly more likely to be of higher severity with the addition of CPG 7909. Anti-AMA1 immunoglobulin G (IgG were detected by enzyme-linked immunosorbent assay (ELISA, and the immune sera of volunteers that received 20 microg or 80 microg of AMA1-C1/Alhydrogel+CPG 7909 had up to 14 fold significant increases in anti-AMA1 antibody concentration compared to 80 microg of AMA1-C1/Alhydrogel alone. The addition of CPG 7909 to the AMA1-C1/Alhydrogel vaccine in humans also elicited AMA1 specific immune IgG that significantly and dramatically increased the in vitro growth inhibition of homologous parasites to levels as high as 96% inhibition. CONCLUSION/SIGNIFICANCE: The safety profile of the AMA1-C1/Alhydrogel+CPG 7909 malaria vaccine is acceptable, given the significant increase in immunogenicity observed. Further clinical development is ongoing. TRIAL REGISTRATION: ClinicalTrials.gov NCT00344539.

  20. Phase 1/2a study of the malaria vaccine candidate apical membrane antigen-1 (AMA-l) administered in adjuvant system AS01B or AS02A

    NARCIS (Netherlands)

    M.D. Spring (Michele Donna); J.F. Cummings (James); C.F. Ockenhouse (Christian); S. Dutta (Shantanu); R. Reidler (Randall); E. Angov (Evelina); E. Bergmann-Leitner (Elke); V.A. Stewart (Ann); S. Bittner (Stacey); L. Juompan (Laure); M.G. Kortepeter (Mark); R. Nielsen (Robin); U. Krzych (Urszula); E. Tierney (Ev); L.A. Ware (Lisa); M. Dowler (Megan); C.C. Hermsen (Cornelus); R.W. Sauerwein (Robert); S.J. de Vlas (Sake); O. Ofori-Anyinam (Opokua); D.E. Lanar (David); J.L. Williams (Jack); K.E. Kester (Kent); K. Tucker (Kathryn); M. Shi (Meng); E. Malkin (Elissa); C. Long (Carole); C.L. Diggs (Carter); L. Soisson (Lorraine Amory); M.C. Dubois; W.R. Ballou (Ripley); J. Cohen (Joe); D.G. Heppner (Gray)

    2009-01-01

    textabstractBackground: This Phase 1/2a study evaluated the safety, immunogenicity, and efficacy of an experimental malaria vaccine comprised of the recombinant Plasmodium falciparum protein apical membrane antigen-1 (AMA-1) representing the 3D7 allele formulated with either the AS01B or AS02A Adjuv

  1. Eocene deep crust at Ama Drime, Tibet

    DEFF Research Database (Denmark)

    Kellett, Dawn; Cottle, John; Smit, Matthijs Arjen

    2014-01-01

    for burial of the lower Indian crust beneath Tibet reported from the central-eastern Himalaya. Granulite-facies overprinting followed at ca. 15–13 Ma, as indicated by U-Pb zircon ages. Unlike ultrahigh-pressure eclogites of the northwest Himalaya, the Ama Drime eclogites are not characteristic of rapid...... burial and exhumation of a cold subducted slab. The rocks instead resulted from crustal thickening during the early stages of continental collision, and resided in the lower-middle crust for >20 m.y. before they were exhumed and reheated. These new data provide solid evidence for the Indian crust having...

  2. Honorary Advisors and Advisors to Tenth National Council of CPAFFC

    Institute of Scientific and Technical Information of China (English)

    2012-01-01

    <正>Honorary Advisors Buhe, former Vice Chairman of the Standing Committee of the National People’s Congress, and President of the China-Poland Friendship Association Tomur Dawamat, former Vice Chairman of the Standing

  3. The Advisor Quality Survey: Good College Advisors Are Available, Knowledgeable, and Autonomy Supportive

    Science.gov (United States)

    Sheldon, Kennon M.; Garton, Bryan; Orr, Rachael; Smith, Amy

    2015-01-01

    Most US institutions of higher education do not assess advisor quality. We report a scale development effort informed by the developmental prescriptions of self-determination theory (Deci & Ryan, 1985, 2000). The 15-item Missouri Advisor Quality Survey assesses advisor knowledge, advisor availability, and advisor autonomy supportiveness.…

  4. Analysis list: ama-1 [Chip-atlas[Archive

    Lifescience Database Archive (English)

    Full Text Available ama-1 Adult,Embryo + ce10 http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/target/am...a-1.1.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/target/ama-1.5.tsv http://dbarchive.biosciencedbc....jp/kyushu-u/ce10/target/ama-1.10.tsv http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/ama-1.Adult.tsv,http://dbarchive.bioscience...dbc.jp/kyushu-u/ce10/colo/ama-1.Embryo.tsv http://dbarchive.bioscience...dbc.jp/kyushu-u/ce10/colo/Adult.gml,http://dbarchive.biosciencedbc.jp/kyushu-u/ce10/colo/Embryo.gml ...

  5. 76 FR 823 - Registration of Municipal Advisors

    Science.gov (United States)

    2011-01-06

    ..., Reforming Corporate Governance, State Government News (June/July 2003), available at http://www.csg.org... Municipal Advisors 1. Proposed Rule 15Ba1-1: Definition of ``Municipal Advisor'' and Related Terms a. Statutory Definition of ``Municipal Advisor'' b. Interpretation of the Term ``Municipal...

  6. Building knowledge systems for sustainable agriculture: Supporting private advisors to adequately address sustainable farm management in regular service contacts

    NARCIS (Netherlands)

    Klerkx, L.W.A.; Jansen, J.

    2010-01-01

    Advisory service provisioning on sustainability issues such as the environment and food safety is considered suboptimal in privatised pluralistic agricultural extension systems. Hence policy measures have been proposed to stimulate farmer demand for such sustainable farm management advice (pull

  7. Solar Advisor Model User Guide for Version 2.0

    Energy Technology Data Exchange (ETDEWEB)

    Gilman, P.; Blair, N.; Mehos, M.; Christensen, C.; Janzou, S.; Cameron, C.

    2008-08-01

    The Solar Advisor Model (SAM) provides a consistent framework for analyzing and comparing power system costs and performance across the range of solar technologies and markets, from photovoltaic systems for residential and commercial markets to concentrating solar power and large photovoltaic systems for utility markets. This manual describes Version 2.0 of the software, which can model photovoltaic and concentrating solar power technologies for electric applications for several markets. The current version of the Solar Advisor Model does not model solar heating and lighting technologies.

  8. On the concepts of amae and the mother-group.

    Science.gov (United States)

    Scheidlinger, S

    1999-01-01

    Notwithstanding Freud's (1921) early linkage of psychoanalytic group psychology with patriarchal themes (i.e., father-leader), more recent findings suggest that the regression in group behavior in general, and in group psychotherapy in particular, tends to evoke frequent maternal ideations. In this connection, this article points to a phenomenological relationship between the individual's universal need to be at one with the internalized mother, as exemplified in the Japanese concept of amae and that of the Mother-Group. With amae serving as an explanatory construct for the group members' interpersonal relations (i.e., identifications and transferences), the idea of the Mother-Group ties in with the group entity's simultaneous supportive functions (i.e., "we are all in the same boat") coupled with its role as a collective arena for the reactivation of unconscious wishes for the nurturing mother of early childhood. In linking a Japanese psychological concept with another, which was developed in the West, I am disproving Rudyard Kipling's often quoted assertion that "never the East and the West shall meet." I was encouraged in this task by Takeo Doi's written comment to me that the idea of the Mother-Group "certainly can be linked with that of Amae. For instance, when the group functions as the Mother-Group, you can say that the participants are experiencing Amae in one way or another" (T. Doi, Sept. 17, 1993, personal communication). In an extended sense, one hopes this essay might even serve to revive our interest in the interrupted well-known early collaboration of psychoanalysts and of anthropologists, which had begun to forge a way to connect personality formation with its cultural context (LeVine, 1974). The insufficient attention paid to the influence of cultural factors on attachment behavior was recently decried by Bretherton (1997).

  9. Education, consultation, guidance, students, advisor, teacher

    Directory of Open Access Journals (Sweden)

    M Seyedmajidi

    2013-09-01

    Full Text Available Introduction: Student counseling and supervision play an important role to overcome learning problems and to achieve educational goals. The present study is intended to investigate viewpoints of students regarding educational guidance and advice studying at Babol University of Medical Sciences. Methods: In this descriptive cross-sectional survey, viewpoints of 480 students were collected by a questionnaire. The validity and reliability of the questionnaire had been approved before. Data were analyzed using SPSS version 17 software. Chi- square and ANOVA tests were administered. Results: 61.2% of all participants were female and 38.8% were males with mean age of 21.3±4.0. 37.2% of these students lacked sufficient knowledge and information on how to request from their advisors for help and guidance. Half of students (50.3% reported attendance of advisors and holding routine consultation is inappropriate. Advisors made more educational files for females compare to males (P=0.001. No difference observed regarding educational disciplines of the advisors regarding students were dissatisfied with help and guidance received from paramedics and dentistry students in most fields (87.3% and 81.5% respectively. Conclusion: It seems that either student has no sufficient information about tasks of advisors and/or advisors may not do their tasks properly. It is recommended the students to be acquainted with advisors’ tasks upon their entrance into the university. Training classes for new academics would be helpful.

  10. Lack of allele-specific efficacy of a bivalent AMA1 malaria vaccine

    Directory of Open Access Journals (Sweden)

    Ellis Ruth D

    2010-06-01

    Full Text Available Abstract Background Extensive genetic diversity in vaccine antigens may contribute to the lack of efficacy of blood stage malaria vaccines. Apical membrane antigen-1 (AMA1 is a leading blood stage malaria vaccine candidate with extreme diversity, potentially limiting its efficacy against infection and disease caused by Plasmodium falciparum parasites with diverse forms of AMA1. Methods Three hundred Malian children participated in a Phase 2 clinical trial of a bivalent malaria vaccine that found no protective efficacy. The vaccine consists of recombinant AMA1 based on the 3D7 and FVO strains of P. falciparum adjuvanted with aluminum hydroxide (AMA1-C1. The gene encoding AMA1 was sequenced from P. falciparum infections experienced before and after immunization with the study vaccine or a control vaccine. Sequences of ama1 from infections in the malaria vaccine and control groups were compared with regard to similarity to the vaccine antigens using several measures of genetic diversity. Time to infection with parasites carrying AMA1 haplotypes similar to the vaccine strains with respect to immunologically important polymorphisms and the risk of infection with vaccine strain haplotypes were compared. Results Based on 62 polymorphic AMA1 residues, 186 unique ama1 haplotypes were identified among 315 ama1 sequences that were included in the analysis. Eight infections had ama1 sequences identical to 3D7 while none were identical to FVO. Several measures of genetic diversity showed that ama1 sequences in the malaria vaccine and control groups were comparable both at baseline and during follow up period. Pre- and post-immunization ama1 sequences in both groups all had a similar degree of genetic distance from FVO and 3D7 ama1. No differences were found in the time of first clinical episode or risk of infection with an AMA1 haplotype similar to 3D7 or FVO with respect to a limited set of immunologically important polymorphisms found in the cluster 1 loop

  11. Advisees' Expectations for Support as Moderator between Advisor Behavior and Advisee Perceptions of Advisor Behavior

    Science.gov (United States)

    Fullick, Julia M.; Smith-Jentsch, Kimberly A.

    2013-01-01

    We tested relationships between students' expectations of psychosocial and career support through a peer advising program, the frequency of advisor behaviors consistent with these types of support (coded from transcripts), and advisee perceptions after receiving such support. Participants were 179 advisor-advisee dyads at a large southeastern…

  12. Cloning and Expression of Ama r 1, as a Novel Allergen of Amaranthus retroflexus Pollen

    Directory of Open Access Journals (Sweden)

    Payam Morakabati

    2016-01-01

    Full Text Available Sensitisation to Amaranthus retroflexus pollen is very common in tropical and subtropical countries. In this study we aimed to produce a recombinant allergenic Ole e 1-like protein from the pollen of this weed. To predict cross-reactivity of this allergen (Ama r 1 with other members of the Ole e 1-like protein family, the nucleotide sequence homology of the Ama r 1 was investigated. The expression of Ama r 1 in Escherichia coli was performed by using a pET-21b(+ vector. The IgE-binding potential of recombinant Ama r 1 (rAma r 1 was evaluated by immunodetection and inhibition assays using 26 patients’ sera sensitised to A. retroflexus pollen. The coding sequence of the Ama r 1 cDNA indicated an open reading frame of 507 bp encoding for 168 amino acid residues which belonged to the Ole e 1-like protein family. Of the 26 serum samples, 10 (38.46% had significant specific IgE levels for rAma r 1. Immunodetection and inhibition assays revealed that the purified rAma r 1 might be the same as that in the crude extract. Ama r 1, the second allergen from the A. retroflexus pollen, was identified as a member of the family of Ole e 1-like protein.

  13. Matching Study on Power System for a Hybrid Electric Bus Based on ADVISOR Simulation%基于ADVISOR仿真的混合动力客车动力系统匹配研究

    Institute of Scientific and Technical Information of China (English)

    严程健; 夏靖武; 崔月月

    2014-01-01

    The authors analyse the working principle of a single-axle hybrid power system, do the matching calcula-tion of key components of the powertrain, make the secondary development for the electric vehicle simulation soft-ware ADVISOR in Matlab/Simulink, insert the power system control strategy, and take a simulation analysis on the power and economy properties. The results provide references for the matching design of a hybrid electric bus power system.%分析一种单轴并联式混合动力系统的工作原理,对动力总成关键部件进行匹配计算。在Matlab/Simulink环境下,对电动汽车仿真软件ADVISOR进行二次开发,嵌入动力系统的控制策略,对整车进行动力性和经济性仿真分析,为混合动力客车动力系统的匹配设计提供参考。

  14. [Clarification of Amae as a concept--response to the criticism by K. Nagayama].

    Science.gov (United States)

    Doi, T

    1998-01-01

    Nagayama wrote a lengthy paper in order to demonstrate that the amae theory which I propounded is all confused. I should say on the contrary that the confusion is his own because he dose not realize that he and I may mean different things by the same word amae. Apparently he means those phenomena that indicate the fulfilment of amae, while I take amae as a verbnoun of amaeru meaning the operation of amaeru in one way or another irrespective of the outcome, its prototype being that of an infant seeking its mother. In short, for Nagayama amae is a characteristic of certain Japanese phenomena and for me a concept. It may refer, in psychoanalytic thinking, to that primordial urge for object relations. It makes no sense therefore to censure my wording of amae like 'narcissistic amae' as not measuring up to the true state of amae as Nagayama defines it, because my usage of the word amae is entirely different from his. In this connection I may point out a curious resemblance between the dismissive manner of his criticism and the behavior of a small group embodying amae which he characterizes as distinctly exclusive of outsiders. There is a good reason to believe that the resemblance is not accidental. I must say that Nagayama is most confused in his critical appraisal of the amae theory against Balint's theory. He completely ignores the fact that these two theories developed independently though there is a definite parallel between them. He then takes me to task that I did not properly incorporate Balint's late ideas into my thinking, even though those ideas became known only in the books published after that book of mine which is the butt of his criticism. Nagayama attempts to trace the amae phenomena back to some racial unconscious underlying Japanese culture. He may believe so, but it sharply contrasts with my view that the very availability of such a concept like amae is indicative of the tenor of Japanese culture. It is interesting to note here that all critics of

  15. Detailed functional characterization of glycosylated and nonglycosylated variants of malaria vaccine candidate PfAMA1 produced in Nicotiana benthamiana and analysis of growth inhibitory responses in rabbits.

    Science.gov (United States)

    Boes, Alexander; Spiegel, Holger; Edgue, Gueven; Kapelski, Stephanie; Scheuermayer, Matthias; Fendel, Rolf; Remarque, Edmond; Altmann, Friedrich; Maresch, Daniel; Reimann, Andreas; Pradel, Gabriele; Schillberg, Stefan; Fischer, Rainer

    2015-02-01

    One of the most promising malaria vaccine candidate antigens is the Plasmodium falciparum apical membrane antigen 1 (PfAMA1). Several studies have shown that this blood-stage antigen can induce strong parasite growth inhibitory antibody responses. PfAMA1 contains up to six recognition sites for N-linked glycosylation, a post-translational modification that is absent in P. falciparum. To prevent any potential negative impact of N-glycosylation, the recognition sites have been knocked out in most PfAMA1 variants expressed in eukaryotic hosts. However, N-linked glycosylation may increase efficacy by improving immunogenicity and/or focusing the response towards relevant epitopes by glycan masking. We describe the production of glycosylated and nonglycosylated PfAMA1 in Nicotiana benthamiana and its detailed characterization in terms of yield, integrity and protective efficacy. Both PfAMA1 variants accumulated to high levels (>510 μg/g fresh leaf weight) after transient expression, and high-mannose-type N-glycans were confirmed for the glycosylated variant. No significant differences between the N. benthamiana and Pichia pastoris PfAMA1 variants were detected in conformation-sensitive ligand-binding studies. Specific titres of >2 × 10(6) were induced in rabbits, and strong reactivity with P. falciparum schizonts was observed in immunofluorescence assays, as well as up to 100% parasite growth inhibition for both variants, with IC₅₀ values of ~35 μg/mL. Competition assays indicated that a number of epitopes were shielded from immune recognition by N-glycans, warranting further studies to determine how glycosylation can be used for the directed targeting of immune responses. These results highlight the potential of plant transient expression systems as a production platform for vaccine candidates.

  16. Deep redevelopment of ADVISOR for simulation of pure electric vehicle with dual-source energy storage system%ADVISOR深度二次开发与双能量源纯电动汽车仿真

    Institute of Scientific and Technical Information of China (English)

    张昌利; 张瑾瑾; 刘海波

    2012-01-01

    通过ADVISOR软件深度二次开发,建立蓄电池-超级电容双能量源纯电动汽车的仿真模型及仿真软件平台,利用软件平台对双能量源纯电动汽车的整车经济性能和动力性能进行仿真分析.研究结果表明:与原ADVISOR软件相比,深度二次开发后的仿真软件平台使用XML配置文件在仿真框架、仿真模型和仿真数据之间建立弱耦合关系,利于将软件平台向其他电动汽车车型移植;使用.NET与MATLAB混合编程充分发挥了2种工具的各自优势,并通过仿真融合使软件平台的界面具有更好的集成性和友好性;该软件平台能够更好地为双能量源纯电动汽车的车辆零部件选型、参数匹配与优化、实验样车研发等工作提供仿真支持.%Through the deep redevelopment of ADVISOR software, the simulation models of pure electric vehicle (PEV) with dual-source energy storage system (DESS) composed of batteries and ultra-capacitors, as well as the simulation software platform, were established. Economical efficiency and the dynamic property of the PEV with DESS were analyzed through simulation experiment on this platform. The results show that compared with ADVISOR software, there are several superiorities of this simulation software platform. Firstly, this platform establishes a lower coupling relationship among the simulation framework, the simulation model and the simulation data with an XML configuration file, and thus it is more convenient to transplant this platform to other types of electric vehicles. Secondly, it takes the advantages of .NET and MATLAB by mixed programming with both tools. Thirdly, the graphic user interface of this platform is more integrated and friendlier. In conclusion, this platform can support the simulation works for electric vehicle development, such as the selection of vehicle components, the match and optimization of vehicle parameters, and the development of vehicle prototypes, etc.

  17. 31 CFR 10.33 - Best practices for tax advisors.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Best practices for tax advisors. 10... Service § 10.33 Best practices for tax advisors. (a) Best practices. Tax advisors should provide clients with the highest quality representation concerning Federal tax issues by adhering to best practices...

  18. How I Chose My Thesis Advisor

    Science.gov (United States)

    Karimabadi, Homa

    2011-01-01

    Professor K. Papadopoulos, or Dennis, who we have all come to him as, has had a profound influence over my career as a scientist as well as my private life. Here I provide a brief account of the events that led me to Dennis as my PhD thesis advisor at University of Maryland and what that has meant to me.

  19. Identification and characterization of Eimeria tenella apical membrane antigen-1 (AMA1.

    Directory of Open Access Journals (Sweden)

    Lianlian Jiang

    Full Text Available Apical membrane antigen-1 (AMA1 is a micronemal protein of apicomplexan parasites that appears to be essential during the invasion of host cells. In this study, a full-length cDNA of AMA1 was identified from Eimeria tenella (Et using expressed sequence tag and the rapid amplification of cDNA ends technique. EtAMA1 had an open reading frame of 1608 bp encoding a protein of 535 amino acids. Quantitative real-time PCR analysis revealed that EtAMA1 was expressed at higher levels in sporozoites than in the other developmental stages (unsporulated oocysts, sporulated oocysts and second-generation merozoites. The ectodomain sequence was expressed as recombinant EtAMA1 (rEtAMA1 and rabbit polyclonal antibodies raised against the rEtAMA1 recognized a 58-kDa native parasite protein by Western Blotting and had a potent inhibitory effect on parasite invasion, decreasing it by approximately 70%. Immunofluorescence analysis and immunohistochemistry analysis showed EtAMA1 might play an important role in sporozoite invasion and development.

  20. Identification of a New Allergen from Amaranthus retroflexus Pollen, Ama r 2

    Directory of Open Access Journals (Sweden)

    Mohsen Tehrani

    2011-01-01

    Conclusions: The profilin from the A. retroflexus pollen, Ama r 2, was firstly identified as an allergen. Moreover, rAma r 2 was produced in E. coli as a soluble immunoreactive protein with an IgE-reactivity similar to that of its natural counterpart.

  1. Bioinformatic Identification of Peptidomimetic-Based Inhibitors against Plasmodium falciparum Antigen AMA1

    Science.gov (United States)

    2014-01-01

    Plasmodium falciparum apical membrane antigen 1 (PfAMA1) is a valuable vaccine candidate and exported on the merozoite surface at the time of erythrocyte invasion. PfAMA1 interacts with rhoptry neck protein PfRON2, a component of the rhoptry protein complex, which forms the tight junction at the time of invasion. Phage display studies have identified a 15-residue (F1) and a 20-residue (R1) peptide that bind to PfAMA1 and block the invasion of erythrocytes. Cocrystal structures of central region of PfAMA1 containing disulfide-linked clusters (domains I and II) with R1 peptide and a peptide derived from PfRON2 showed strong structural similarity in binding. The peptides bound to a hydrophobic groove surrounded by domain I and II loops. In this study, peptidomimetics based on the crucial PfAMA1-binding residues of PfRON2 peptide have been identified. Top 5 peptidomimetics when checked for their docking on the region of PfAMA1 encompassing the hydrophobic groove were found to dock on the groove. Drug-like molecules having structural similarity to the top 5 peptidomimetics were identified based on their binding ability to PfAMA1 hydrophobic groove in blind docking. These inhibitors provide potential lead compounds, which could be used in the development of antimalarials targeting PfAMA1. PMID:25580351

  2. Benchmarking parameter-free AMaLGaM on functions with and without noise.

    Science.gov (United States)

    Bosman, Peter A N; Grahl, Jörn; Thierens, Dirk

    2013-01-01

    We describe a parameter-free estimation-of-distribution algorithm (EDA) called the adapted maximum-likelihood Gaussian model iterated density-estimation evolutionary algorithm (AMaLGaM-ID[Formula: see text]A, or AMaLGaM for short) for numerical optimization. AMaLGaM is benchmarked within the 2009 black box optimization benchmarking (BBOB) framework and compared to a variant with incremental model building (iAMaLGaM). We study the implications of factorizing the covariance matrix in the Gaussian distribution, to use only a few or no covariances. Further, AMaLGaM and iAMaLGaM are also evaluated on the noisy BBOB problems and we assess how well multiple evaluations per solution can average out noise. Experimental evidence suggests that parameter-free AMaLGaM can solve a wide range of problems efficiently with perceived polynomial scalability, including multimodal problems, obtaining the best or near-best results among all algorithms tested in 2009 on functions such as the step-ellipsoid and Katsuuras, but failing to locate the optimum within the time limit on skew Rastrigin-Bueche separable and Lunacek bi-Rastrigin in higher dimensions. AMaLGaM is found to be more robust to noise than iAMaLGaM due to the larger required population size. Using few or no covariances hinders the EDA from dealing with rotations of the search space. Finally, the use of noise averaging is found to be less efficient than the direct application of the EDA unless the noise is uniformly distributed. AMaLGaM was among the best performing algorithms submitted to the BBOB workshop in 2009.

  3. 论辅导员以社会主义核心价值体系引领高校校园文化%College Student Advisor Campus Culture with the Socialist Core Value System

    Institute of Scientific and Technical Information of China (English)

    刘锦华; 张建

    2014-01-01

    As the building of socialist advanced culture, an important part of campus culture is a socialist core value system is an important carrier.college student advisors should fully understand the socialist core value system to lead the campus culture, the importance of building a socialist core value system of the profound grasp of the bas-ic content of the campus culture always adhere to the socialist core value system-oriented features, to mobilize the main motivation of students to carry out a variety of campus cultural activities, play network media effects.%作为社会主义先进文化建设的重要组成部分,高校校园文化是社会主义核心价值体系的重要载体。高校辅导员应充分认清以社会主义核心价值体系引领高校校园文化建设的重要性,深刻把握社会主义核心价值体系的基本内涵,在校园文化建设中始终坚持社会主义核心价值体系的导向功能,调动学生的积极性,开展丰富多彩的校园文化活动,发挥网络传播媒介的效应。

  4. AMA Conferences 2015. SENSOR 2015. 17th international conference on sensors and measurement technology. IRS{sup 2} 2015. 14th international conference on infrared sensors and systems. Proceedings

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-07-01

    This meeting paper contains presentations of two conferences: SENSOR 2015 and IRS{sup 2} (= International conference on InfraRed Sensors and systems). The first part of SENSOR 2015 contains the following chapters: (A) SENSOR PRINCIPLES: A.1: Mechanical sensors; A.2: Optical sensors; A.3: Ultrasonic sensors; A.4: Microacoustic sensors; A.5: Magnetic sensors; A.6: Impedance sensors; A.7: Gas sensors; A.8: Flow sensors; A.9: Dimensional measurement; A.10: Temperature and humidity sensors; A.11: Chemosensors; A.12: Biosensors; A.13: Embedded sensors; A.14: Sensor-actuator systems; (B) SENSOR TECHNOLOGY: B.1: Sensor design; B.2: Numerical simulation of sensors; B.3: Sensor materials; B.4: MEMS technology; B.5: Micro-Nano-Integration; B.6: Packaging; B.7: Materials; B.8: Thin films; B.9: Sensor production; B.10: Sensor reliability; B.11: Calibration and testing; B.12: Optical fibre sensors. (C) SENSOR ELECTRONICS AND COMMUNICATION: C.1: Sensor electronics; C.2: Sensor networks; C.3: Wireless sensors; C.4: Sensor communication; C.5: Energy harvesting; C.6: Measuring systems; C.7: Embedded systems; C.8: Self-monitoring and diagnosis; (D) APPLICATIONS: D.1: Medical measuring technology; D.2: Ambient assisted living; D.3: Process measuring technology; D.4: Automotive; D.5: Sensors in energy technology; D.6: Production technology; D.7: Security technology; D.8: Smart home; D.9: Household technology. The second part with the contributions of the IRS{sup 2} 2015 is structured as follows: (E) INFRARED SENSORS: E.1: Photon detectors; E.2: Thermal detectors; E.3: Cooled detectors; E.4: Uncooled detectors; E.5: Sensor modules; E.6: Sensor packaging. (G) INFRARED SYSTEMS AND APPLICATIONS: G.1: Thermal imaging; G.2: Pyrometry / contactless temperature measurement; G.3: Gas analysis; G.4: Spectroscopy; G.5: Motion control and presence detection; G.6: Security and safety monitoring; G.7: Non-destructive testing; F: INFRARED SYSTEM COMPONENTS: F.1: Infrared optics; F.2: Optical

  5. Methodes d'amas quantiques a temperature finie appliquees au modele de Hubbard

    Science.gov (United States)

    Plouffe, Dany

    Depuis leur decouverte dans les annees 80, les supraconducteurs a haute temperature critique ont suscite beaucoup d'interet en physique du solide. Comprendre l'origine des phases observees dans ces materiaux, telle la supraconductivite, est l'un des grands defis de la physique theorique du solide des 25 dernieres annees. L'un des mecanismes pressentis pour expliquer ces phenomenes est la forte interaction electron-electron. Le modele de Hubbard est l'un des modeles les plus simples pour tenir compte de ces interactions. Malgre la simplicite apparente de ce modele, certaines de ses caracteristiques, dont son diagramme de phase, ne sont toujours pas bien etablies, et ce malgre plusieurs avancements theoriques dans les dernieres annees. Cette etude se consacre a faire une analyse de methodes numeriques permettant de calculer diverses proprietes du modele de Hubbard en fonction de la temperature. Nous decrivons des methodes (la VCA et la CPT) qui permettent de calculer approximativement la fonction de Green a temperature finie sur un systeme infini a partir de la fonction de Green calculee sur un amas de taille finie. Pour calculer ces fonctions de Green, nous allons utiliser des methodes permettant de reduire considerablement les efforts numeriques necessaires pour les calculs des moyennes thermodynamiques, en reduisant considerablement l'espace des etats a considerer dans ces moyennes. Bien que cette etude vise d'abord a developper des methodes d'amas pour resoudre le modele de Hubbard a temperature finie de facon generale ainsi qu'a etudier les proprietes de base de ce modele, nous allons l'appliquer a des conditions qui s'approchent de supraconducteurs a haute temperature critique. Les methodes presentees dans cette etude permettent de tracer un diagramme de phase pour l'antiferromagnetisme et la supraconductivite qui presentent plusieurs similarites avec celui des supraconducteurs a haute temperature. Mots-cles : modele de Hubbard, thermodynamique

  6. Marine Advisor Advantage: Institutionalizing Security Force Assistance

    Science.gov (United States)

    2013-04-16

    serve as a plank -holder in the formation of the Marine Corps Training and Advisory Group (MCTAG) which later merged with the Security Cooperation...Focus: The Future of Your Company Depends on It (New York: Harper Business, 1996), 269 54 Max Boot, The Savage Wars of Peace: Small Wars and the...Gazette, November, 2011, 44-47. Boot, Max . “Iraq’s Advisor Gap.” Los Angeles Times, October 18, 2006. Boot, Max . The Savage Wars of Peace

  7. On the Ground: Advisor Lessons Learned

    Science.gov (United States)

    2013-12-01

    unprecedented opportunity to financial, logistical and acquisition professionals. The MoD Advisory ( MoDA ) program allows selected DoD professionals...to serve within the security min- istries as advisors. Managed by the Defense Security Cooperation Agency, the MoDA program provides formal classroom...well worth it. The stated pillars of MoDA training are humility, compassion and respect. Working with senior leaders of the Afghan MoD gave me

  8. The figure of the helper advisor in cases of sexual abuse against people with intellectual disabilities

    Directory of Open Access Journals (Sweden)

    Almudena MARTORELL CAFRANGA

    2017-09-01

    Full Text Available In this paper we analyse the main barriers that people with intellectual disabilities who have suffered sexual abuse have to face when they access the Justice system. Regarding these barriers, the Victim Support Unit for People with Intellectual Disabilities of the Fundación Carmen Pardo-Valcarce proposes the inclusion in the judicial process of a helper advisor. The entry into force in 2015 of the Law 4/2015, in 27 April, the Statute of the crime victim represents an exemplary opportunity to ensure the incorporation of support proposals involving the insertion of the helper advisor in the judicial process in cases where the victim is a person with intellectual disabilities. In this paper we analyse the impact of the helper advisor, with particular emphasis on cases that have been dismissed under instruction.

  9. Automated Manpower Analysis and Personnel Management System (AMA/PMS).

    OpenAIRE

    Schwind, Cynthia E.

    1992-01-01

    Approved for public release; distribution is unlimited In a peacetime environment of increasing budget cuts resulting in reduced manning levels, active management of limited manpower assets is vital to ensure mission accomplishment and battle readiness. Manpower analysis is the process by which an activity's manpower assets are matched to or balanced against authorized billets to determine strengths and weaknesses in manning structure. Manpower analysis must be perform...

  10. Bacteriocin production by Lactobacillus plantarum AMA-K isolated from Amasi, a Zimbabwean fermented milk product and study of the adsorption of bacteriocin AMA-K to Listeria sp. Otimização da produção de bacteriocina por Lactobacillus plantarum AMA-K isolado de Amasi, um produto lácteo fermentado de Zimbabwe, e estudo da adsorção da bacteriocina AMA-K à Listeria innocua, Listeria monocytogenes e Listeria ivanovii subsp. ivanovii

    OpenAIRE

    Svetoslav D. Todorov

    2008-01-01

    Bacteriocin AMA-K produced by Lactobacillus plantarum AMA-K inhibits the growth of Enterococcus spp., Escherichia coli, Klebsiella pneumoniae and Listeria spp. Growth of strain AMA-K in BHI, M17, soy milk and molasses was similar to growth in MRS. The effect of organic nitrogen sources, carbohydrates, glycerol, K2HPO4 and KH2PO4, MgSO4, MnSO4, tri-ammonium citrate, Tween 80, vitamins and initial pH on bacteriocin AMA-K was determined. The mode of action of bacteriocin AMA-K was studied. The e...

  11. Airport Perimeter Security Advisor Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The aviation system of the United States of America is one of our national treasures. Very few elements of our culture capture the America spirit like aviation. Air...

  12. Solar Effective Envelope Design Advisor (SEEDA)

    Science.gov (United States)

    Mahaek, Ekkachai

    The lack of effort by mainstream architects in integrating energy-efficient strategies in architectural designing is due to the complexity in a building's energy conscious concepts and theories, the difficulties to visualize and quantify energy consumption, and the late implementing of energy consumption analysis in the conventional design process. This task would be accomplishing by a building system's engineer where results might be determined only after the basic architectural design has been completed. An effective simple tool and method should then be available to assist architects in building's energy-efficient designing at the beginning of the design. The building's energy consumption is directly and mainly influenced by the relationship of the sun, site, and its building configuration. The solar radiations will first impact on the building's envelope, which will have a direct effect on the amount of energy a building will consume. If an architect can define or map the intensity of solar energy on the site's buildable volume, and use this information to determine the levels of solar insolation, a more energy efficient building form can be proposed. This research hypothesis has shared the fundamental techniques of the Solar Envelope projection by Professor Ralph Knowles [Knowles, 1981] of the University of Southern California. However a different approach is taken by including the influence of regional restrictions and the surrounding buildings' shadows when projecting of solar volumes and solar envelope. The research methodology will discuss the development of a computer-based approach to develop a three-dimensional architectural form based on an insolation map related to the design site. The prototype computer program is referred as the Solar Effective Envelope Design Advisor (SEEDA). The solar insolation volume of the site is determined by integrating three types of computer-generated models include the Buildable Volume model based on design constraints

  13. "Tell Me, Nana": The Image of the Grandmother in the Works of Ama Ata Aidoo.

    Science.gov (United States)

    Hill-Lubin, Mildred A.

    1988-01-01

    Analyzes the role of the grandmother in the African extended family as portrayed in the work of Ghanian author and playwright, Ama Ata Aidoo. Discusses her functions as foster parent, babysitter, psychologist, teacher, and confidante. (FMW)

  14. 77 FR 59061 - Extension of Temporary Registration of Municipal Advisors

    Science.gov (United States)

    2012-09-26

    ... Strategies, dated October 5, 2010; Steve Apfelbacher, President, National Association of Independent Public Finance Advisors, dated October 8, 2010; Carolyn Walsh, Vice President and Senior Counsel, Center...

  15. Effect of Oxytropis glabra DC. Poisoning on α-Mannosidase(AMA) Expression in Mice Brain Tissue

    Institute of Scientific and Technical Information of China (English)

    Wang Shuai; Jia Qizhen; Zhang Ling; Chen Genyuan; Ma Chunhui

    2015-01-01

    The effect of Oxytropis glabra DC. on α-mannosidase( AMA) expression in mice brain tissue was explored to reveal the toxicity mechanism of O. glabra. Forty mice were randomly divided into four groups,namely control group,experimental group I,experimental group II and experimental group III. The mice in three experimental groups were fed with O. glabra at the doses of 1,5 and 10 g per kilogram weight,respectively. After challenge for 63 d,mice brains were collected to detect changes in distribution and expression of AMA in different brain regions. The results showed that O. glabra poisoning led to declined AMA mRNA expression in mice brain tissue,but the mice in experimental group I had no significant difference with those in control group( P > 0. 05). The AMA mRNA expression in cerebellum,cerebrum and thalamus of mice in experimental groups II and III were significantly lower than that in control group( P 0. 05). AMA had very weak expression in hippocampus and brainstem,but it had expressions in other regions,and the expression was positively correlated with the number of neurons and granulosa cells. The results showed that different doses of O. glabra reduced AMA mRNA expression in mice brain tissue,while cerebellum,cerebrum and thalamus were the main target function areas.

  16. The role of farm advisors in multifunctional landscapes

    DEFF Research Database (Denmark)

    Vesterager, Jens Peter; Lindegaard, Klaus

    2012-01-01

    This study investigates the influence of farm advisors on farmers decisions regarding Multifunctional landscape commons, a concept covering environmental and landscape values that benefit the public but which depend on farmers management practices. The influence of advisors is analysed by combining...

  17. Academic Advisors of Military and Student Veterans: An Ethnographic Study

    Science.gov (United States)

    Miller, Michelle A.

    2015-01-01

    With the introduction of the Post-9/11 GI Bill, there is an influx of active-duty military and student veterans enrolling in postsecondary and graduate-level education. The role of an academic advisor increases significantly with this influx of enrollment. The purpose of this study was to determine how a graduate-level academic advisor perceives…

  18. 78 FR 27444 - Forum Investment Advisors, LLC, et al.;

    Science.gov (United States)

    2013-05-10

    ... COMMISSION Forum Investment Advisors, LLC, et al.; Notice of Application May 6, 2013. AGENCY: Securities and... the Investment Company Act of 1940 (``Act'') for an exemption from sections 2(a)(32), 5(a)(1), 22(d... exemption from sections 12(d)(1)(A) and 12(d)(1)(B) of the Act. Applicants: Forum Investment Advisors,...

  19. Juxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodies.

    Directory of Open Access Journals (Sweden)

    Anna Olivieri

    2011-12-01

    Full Text Available The malarial life cycle involves repeated rounds of intraerythrocytic replication interspersed by host cell rupture which releases merozoites that rapidly invade fresh erythrocytes. Apical membrane antigen-1 (AMA1 is a merozoite protein that plays a critical role in invasion. Antibodies against AMA1 prevent invasion and can protect against malaria in vivo, so AMA1 is of interest as a malaria vaccine candidate. AMA1 is efficiently shed from the invading parasite surface, predominantly through juxtamembrane cleavage by a membrane-bound protease called SUB2, but also by limited intramembrane cleavage. We have investigated the structural requirements for shedding of Plasmodium falciparum AMA1 (PfAMA1, and the consequences of its inhibition. Mutagenesis of the intramembrane cleavage site by targeted homologous recombination abolished intramembrane cleavage with no effect on parasite viability in vitro. Examination of PfSUB2-mediated shedding of episomally-expressed PfAMA1 revealed that the position of cleavage is determined primarily by its distance from the parasite membrane. Certain mutations at the PfSUB2 cleavage site block shedding, and parasites expressing these non-cleavable forms of PfAMA1 on a background of expression of the wild type gene invade and replicate normally in vitro. The non-cleavable PfAMA1 is also functional in invasion. However - in contrast to the intramembrane cleavage site - mutations that block PfSUB2-mediated shedding could not be stably introduced into the genomic pfama1 locus, indicating that some shedding of PfAMA1 by PfSUB2 is essential. Remarkably, parasites expressing shedding-resistant forms of PfAMA1 exhibit enhanced sensitivity to antibody-mediated inhibition of invasion. Drugs that inhibit PfSUB2 activity should block parasite replication and may also enhance the efficacy of vaccines based on AMA1 and other merozoite surface proteins.

  20. Juxtamembrane shedding of Plasmodium falciparum AMA1 is sequence independent and essential, and helps evade invasion-inhibitory antibodies.

    Science.gov (United States)

    Olivieri, Anna; Collins, Christine R; Hackett, Fiona; Withers-Martinez, Chrislaine; Marshall, Joshua; Flynn, Helen R; Skehel, J Mark; Blackman, Michael J

    2011-12-01

    The malarial life cycle involves repeated rounds of intraerythrocytic replication interspersed by host cell rupture which releases merozoites that rapidly invade fresh erythrocytes. Apical membrane antigen-1 (AMA1) is a merozoite protein that plays a critical role in invasion. Antibodies against AMA1 prevent invasion and can protect against malaria in vivo, so AMA1 is of interest as a malaria vaccine candidate. AMA1 is efficiently shed from the invading parasite surface, predominantly through juxtamembrane cleavage by a membrane-bound protease called SUB2, but also by limited intramembrane cleavage. We have investigated the structural requirements for shedding of Plasmodium falciparum AMA1 (PfAMA1), and the consequences of its inhibition. Mutagenesis of the intramembrane cleavage site by targeted homologous recombination abolished intramembrane cleavage with no effect on parasite viability in vitro. Examination of PfSUB2-mediated shedding of episomally-expressed PfAMA1 revealed that the position of cleavage is determined primarily by its distance from the parasite membrane. Certain mutations at the PfSUB2 cleavage site block shedding, and parasites expressing these non-cleavable forms of PfAMA1 on a background of expression of the wild type gene invade and replicate normally in vitro. The non-cleavable PfAMA1 is also functional in invasion. However - in contrast to the intramembrane cleavage site - mutations that block PfSUB2-mediated shedding could not be stably introduced into the genomic pfama1 locus, indicating that some shedding of PfAMA1 by PfSUB2 is essential. Remarkably, parasites expressing shedding-resistant forms of PfAMA1 exhibit enhanced sensitivity to antibody-mediated inhibition of invasion. Drugs that inhibit PfSUB2 activity should block parasite replication and may also enhance the efficacy of vaccines based on AMA1 and other merozoite surface proteins.

  1. AMA- and RWE- Based Adaptive Kalman Filter for Denoising Fiber Optic Gyroscope Drift Signal.

    Science.gov (United States)

    Yang, Gongliu; Liu, Yuanyuan; Li, Ming; Song, Shunguang

    2015-10-23

    An improved double-factor adaptive Kalman filter called AMA-RWE-DFAKF is proposed to denoise fiber optic gyroscope (FOG) drift signal in both static and dynamic conditions. The first factor is Kalman gain updated by random weighting estimation (RWE) of the covariance matrix of innovation sequence at any time to ensure the lowest noise level of output, but the inertia of KF response increases in dynamic condition. To decrease the inertia, the second factor is the covariance matrix of predicted state vector adjusted by RWE only when discontinuities are detected by adaptive moving average (AMA).The AMA-RWE-DFAKF is applied for denoising FOG static and dynamic signals, its performance is compared with conventional KF (CKF), RWE-based adaptive KF with gain correction (RWE-AKFG), AMA- and RWE- based dual mode adaptive KF (AMA-RWE-DMAKF). Results of Allan variance on static signal and root mean square error (RMSE) on dynamic signal show that this proposed algorithm outperforms all the considered methods in denoising FOG signal.

  2. Bacteriocin production by Lactobacillus plantarum AMA-K isolated from Amasi, a Zimbabwean fermented milk product and study of the adsorption of bacteriocin AMA-K to Listeria sp. Otimização da produção de bacteriocina por Lactobacillus plantarum AMA-K isolado de Amasi, um produto lácteo fermentado de Zimbabwe, e estudo da adsorção da bacteriocina AMA-K à Listeria innocua, Listeria monocytogenes e Listeria ivanovii subsp. ivanovii

    Directory of Open Access Journals (Sweden)

    Svetoslav D. Todorov

    2008-03-01

    Full Text Available Bacteriocin AMA-K produced by Lactobacillus plantarum AMA-K inhibits the growth of Enterococcus spp., Escherichia coli, Klebsiella pneumoniae and Listeria spp. Growth of strain AMA-K in BHI, M17, soy milk and molasses was similar to growth in MRS. The effect of organic nitrogen sources, carbohydrates, glycerol, K2HPO4 and KH2PO4, MgSO4, MnSO4, tri-ammonium citrate, Tween 80, vitamins and initial pH on bacteriocin AMA-K was determined. The mode of action of bacteriocin AMA-K was studied. The effect of bacteriocin AMA-K to actively growing Listeria innocua LMG13568, L. ivanovii subsp. ivanovii ATCC19119 and L. monocytogenes ScottA was determined. Adsorption of bacteriocin AMA-K to target cells at different temperatures, pH and in presence of Tween 20, Tween 80, ascorbic acid, potassium sorbate, sodium nitrate and sodium chloride were studied. Bacteriocin AMA-K shares high homology to pediocin PA-1.A bacteriocina AMA-K produzida por Lactobacillus plantarum AMA-K inibe a multiplicação de Enterococcus spp, Escherichia coli, Klebsiella pneumoniae e Listeria spp. A multiplicação da cepa AMA-K em BHI, leite de soja e melaço foi semelhante à multiplicação em MRS. O efeito de fontes de nitrogênio orgânico, carboidratos, glicerol, K2HPO4 e KH2PO4, MgSO4, MnSO4, citrato de triamônio, Tween 80, vitaminas e pH inicial sobre a bacteriocina AMA-K foi determinada. O modo de ação da bacteriocina AMA-K foi estudado. O efeito da bacteriocina AMA-K sobre Listeria innocua LMG13568, Listeria ivanovii subsp.ivanovii ATCC19119 e Listeria monocytogenes Scott A foi determinado. A adsorção da bacteriocina AMA-K às células-alvo em diferentes temperaturas, pH e na presença de Tween 20, Tween 80, ácido ascórbico, sorbato de potássio, nitrato de sódio a cloreto de sódio foi avaliada. A bacteriocina AMA-K apresenta grande homologia a pediocina PA-1.

  3. Non-apical membrane antigen 1 (AMA1 IgGs from Malian children interfere with functional activity of AMA1 IgGs as judged by growth inhibition assay.

    Directory of Open Access Journals (Sweden)

    Kazutoyo Miura

    Full Text Available BACKGROUND: Apical membrane antigen 1 (AMA1 is one of the best-studied blood-stage malaria vaccine candidates. When an AMA1 vaccine was tested in a malaria naïve population, it induced functionally active antibodies judged by Growth Inhibition Assay (GIA. However, the same vaccine failed to induce higher growth-inhibitory activity in adults living in a malaria endemic area. Vaccination did induce functionally active antibodies in malaria-exposed children with less than 20% inhibition in GIA at baseline, but not in children with more than that level of baseline inhibition. METHODS: Total IgGs were purified from plasmas collected from the pediatric trial before and after immunization and pools of total IgGs were made. Another set of total IgGs was purified from U.S. adults immunized with AMA1 (US-total IgG. From these total IgGs, AMA1-specific and non-AMA1 IgGs were affinity purified and the functional activity of these IgGs was evaluated by GIA. Competition ELISA was performed with the U.S.-total IgG and non-AMA1 IgGs from malaria-exposed children. RESULTS: AMA1-specific IgGs from malaria-exposed children and U.S. vaccinees showed similar growth-inhibitory activity at the same concentrations. When mixed with U.S.-total IgG, non-AMA1 IgGs from children showed an interference effect in GIA. Interestingly, the interference effect was higher with non-AMA1 IgGs from higher titer pools. The non-AMA1 IgGs did not compete with anti-AMA1 antibody in U.S.-total IgG in the competition ELISA. CONCLUSION: Children living in a malaria endemic area have a fraction of IgGs that interferes with the biological activity of anti-AMA1 antibody as judged by GIA. While the mechanism of interference is not resolved in this study, these results suggest it is not caused by direct competition between non-AMA1 IgG and AMA1 protein. This study indicates that anti-malaria IgGs induced by natural exposure may interfere with the biological effect of antibody induced by an AMA1

  4. A study on optimization of hybrid drive train using Advanced Vehicle Simulator (ADVISOR)

    Science.gov (United States)

    Same, Adam; Stipe, Alex; Grossman, David; Park, Jae Wan

    This study investigates the advantages and disadvantages of three hybrid drive train configurations: series, parallel, and "through-the-ground" parallel. Power flow simulations are conducted with the MATLAB/Simulink-based software ADVISOR. These simulations are then applied in an application for the UC Davis SAE Formula Hybrid vehicle. ADVISOR performs simulation calculations for vehicle position using a combined backward/forward method. These simulations are used to study how efficiency and agility are affected by the motor, fuel converter, and hybrid configuration. Three different vehicle models are developed to optimize the drive train of a vehicle for three stages of the SAE Formula Hybrid competition: autocross, endurance, and acceleration. Input cycles are created based on rough estimates of track geometry. The output from these ADVISOR simulations is a series of plots of velocity profile and energy storage State of Charge that provide a good estimate of how the Formula Hybrid vehicle will perform on the given course. The most noticeable discrepancy between the input cycle and the actual velocity profile of the vehicle occurs during deceleration. A weighted ranking system is developed to organize the simulation results and to determine the best drive train configuration for the Formula Hybrid vehicle. Results show that the through-the-ground parallel configuration with front-mounted motors achieves an optimal balance of efficiency, simplicity, and cost. ADVISOR is proven to be a useful tool for vehicle power train design for the SAE Formula Hybrid competition. This vehicle model based on ADVISOR simulation is applicable to various studies concerning performance and efficiency of hybrid drive trains.

  5. A study on optimization of hybrid drive train using Advanced Vehicle Simulator (ADVISOR)

    Energy Technology Data Exchange (ETDEWEB)

    Same, Adam; Stipe, Alex; Grossman, David; Park, Jae Wan [Department of Mechanical and Aeronautical Engineering, University of California, Davis, One Shields Ave, Davis, CA 95616 (United States)

    2010-10-01

    This study investigates the advantages and disadvantages of three hybrid drive train configurations: series, parallel, and ''through-the-ground'' parallel. Power flow simulations are conducted with the MATLAB/Simulink-based software ADVISOR. These simulations are then applied in an application for the UC Davis SAE Formula Hybrid vehicle. ADVISOR performs simulation calculations for vehicle position using a combined backward/forward method. These simulations are used to study how efficiency and agility are affected by the motor, fuel converter, and hybrid configuration. Three different vehicle models are developed to optimize the drive train of a vehicle for three stages of the SAE Formula Hybrid competition: autocross, endurance, and acceleration. Input cycles are created based on rough estimates of track geometry. The output from these ADVISOR simulations is a series of plots of velocity profile and energy storage State of Charge that provide a good estimate of how the Formula Hybrid vehicle will perform on the given course. The most noticeable discrepancy between the input cycle and the actual velocity profile of the vehicle occurs during deceleration. A weighted ranking system is developed to organize the simulation results and to determine the best drive train configuration for the Formula Hybrid vehicle. Results show that the through-the-ground parallel configuration with front-mounted motors achieves an optimal balance of efficiency, simplicity, and cost. ADVISOR is proven to be a useful tool for vehicle power train design for the SAE Formula Hybrid competition. This vehicle model based on ADVISOR simulation is applicable to various studies concerning performance and efficiency of hybrid drive trains. (author)

  6. AMAS: a fast tool for alignment manipulation and computing of summary statistics

    Directory of Open Access Journals (Sweden)

    Marek L. Borowiec

    2016-01-01

    Full Text Available The amount of data used in phylogenetics has grown explosively in the recent years and many phylogenies are inferred with hundreds or even thousands of loci and many taxa. These modern phylogenomic studies often entail separate analyses of each of the loci in addition to multiple analyses of subsets of genes or concatenated sequences. Computationally efficient tools for handling and computing properties of thousands of single-locus or large concatenated alignments are needed. Here I present AMAS (Alignment Manipulation And Summary, a tool that can be used either as a stand-alone command-line utility or as a Python package. AMAS works on amino acid and nucleotide alignments and combines capabilities of sequence manipulation with a function that calculates basic statistics. The manipulation functions include conversions among popular formats, concatenation, extracting sites and splitting according to a pre-defined partitioning scheme, creation of replicate data sets, and removal of taxa. The statistics calculated include the number of taxa, alignment length, total count of matrix cells, overall number of undetermined characters, percent of missing data, AT and GC contents (for DNA alignments, count and proportion of variable sites, count and proportion of parsimony informative sites, and counts of all characters relevant for a nucleotide or amino acid alphabet. AMAS is particularly suitable for very large alignments with hundreds of taxa and thousands of loci. It is computationally efficient, utilizes parallel processing, and performs better at concatenation than other popular tools. AMAS is a Python 3 program that relies solely on Python’s core modules and needs no additional dependencies. AMAS source code and manual can be downloaded from http://github.com/marekborowiec/AMAS/ under GNU General Public License.

  7. AMAS: a fast tool for alignment manipulation and computing of summary statistics.

    Science.gov (United States)

    Borowiec, Marek L

    2016-01-01

    The amount of data used in phylogenetics has grown explosively in the recent years and many phylogenies are inferred with hundreds or even thousands of loci and many taxa. These modern phylogenomic studies often entail separate analyses of each of the loci in addition to multiple analyses of subsets of genes or concatenated sequences. Computationally efficient tools for handling and computing properties of thousands of single-locus or large concatenated alignments are needed. Here I present AMAS (Alignment Manipulation And Summary), a tool that can be used either as a stand-alone command-line utility or as a Python package. AMAS works on amino acid and nucleotide alignments and combines capabilities of sequence manipulation with a function that calculates basic statistics. The manipulation functions include conversions among popular formats, concatenation, extracting sites and splitting according to a pre-defined partitioning scheme, creation of replicate data sets, and removal of taxa. The statistics calculated include the number of taxa, alignment length, total count of matrix cells, overall number of undetermined characters, percent of missing data, AT and GC contents (for DNA alignments), count and proportion of variable sites, count and proportion of parsimony informative sites, and counts of all characters relevant for a nucleotide or amino acid alphabet. AMAS is particularly suitable for very large alignments with hundreds of taxa and thousands of loci. It is computationally efficient, utilizes parallel processing, and performs better at concatenation than other popular tools. AMAS is a Python 3 program that relies solely on Python's core modules and needs no additional dependencies. AMAS source code and manual can be downloaded from http://github.com/marekborowiec/AMAS/ under GNU General Public License.

  8. Identification of a highly antigenic linear B cell epitope within Plasmodium vivax apical membrane antigen 1 (AMA-1.

    Directory of Open Access Journals (Sweden)

    Lilian Lacerda Bueno

    Full Text Available Apical membrane antigen 1 (AMA-1 is considered to be a major candidate antigen for a malaria vaccine. Previous immunoepidemiological studies of naturally acquired immunity to Plasmodium vivax AMA-1 (PvAMA-1 have shown a higher prevalence of specific antibodies to domain II (DII of AMA-1. In the present study, we confirmed that specific antibody responses from naturally infected individuals were highly reactive to both full-length AMA-1 and DII. Also, we demonstrated a strong association between AMA-1 and DII IgG and IgG subclass responses. We analyzed the primary sequence of PvAMA-1 for B cell linear epitopes co-occurring with intrinsically unstructured/disordered regions (IURs. The B cell epitope comprising the amino acid sequence 290-307 of PvAMA-1 (SASDQPTQYEEEMTDYQK, with the highest prediction scores, was identified in domain II and further selected for chemical synthesis and immunological testing. The antigenicity of the synthetic peptide was identified by serological analysis using sera from P. vivax-infected individuals who were knowingly reactive to the PvAMA-1 ectodomain only, domain II only, or reactive to both antigens. Although the synthetic peptide was recognized by all serum samples specific to domain II, serum with reactivity only to the full-length protein presented 58.3% positivity. Moreover, IgG reactivity against PvAMA-1 and domain II after depletion of specific synthetic peptide antibodies was reduced by 18% and 33% (P = 0.0001 for both, respectively. These results suggest that the linear epitope SASDQPTQYEEEMTDYQK is highly antigenic during natural human infections and is an important antigenic region of the domain II of PvAMA-1, suggesting its possible future use in pre-clinical studies.

  9. Bacteriocin production by Lactobacillus plantarum AMA-K isolated from Amasi, a Zimbabwean fermented milk product and study of the adsorption of bacteriocin AMA-K TO Listeria sp.

    Science.gov (United States)

    Todorov, Svetoslav D

    2008-01-01

    Bacteriocin AMA-K produced by Lactobacillus plantarum AMA-K inhibits the growth of Enterococcus spp., Escherichia coli, Klebsiella pneumoniae and Listeria spp. Growth of strain AMA-K in BHI, M17, soy milk and molasses was similar to growth in MRS. The effect of organic nitrogen sources, carbohydrates, glycerol, K2HPO4 and KH2PO4, MgSO4, MnSO4, tri-ammonium citrate, Tween 80, vitamins and initial pH on bacteriocin AMA-K was determined. The mode of action of bacteriocin AMA-K was studied. The effect of bacteriocin AMA-K to actively growing Listeria innocua LMG13568, L. ivanovii subsp. ivanovii ATCC19119 and L. monocytogenes ScottA was determined. Adsorption of bacteriocin AMA-K to target cells at different temperatures, pH and in presence of Tween 20, Tween 80, ascorbic acid, potassium sorbate, sodium nitrate and sodium chloride were studied. Bacteriocin AMA-K shares high homology to pediocin PA-1.

  10. Advising Indigenous Forces: American Advisors in Korea, Vietnam, and El Salvador

    Science.gov (United States)

    2006-01-01

    attended the MATA, MASA, Military Assistance Program Advisor ( MAPA ), CA Officer, Civic Action, District and CA Advisor, or PSYOPs Unit Officer Course...MAOP Military Assistance Officer Program MAPA Military Assistance Program Advisor MASA Military Assistance Security Advisor MAT Mobile Advisory

  11. Rape victims and victimisers in Herbstein's Ama, a Story of the ...

    African Journals Online (AJOL)

    Reading Ama, a Story of the Atlantic Slave Trade through the lens of ... flaws and highlighting issues relating to cultural differences and hybridity in liter- .... “A term used in linguistics to indicate a suppression or omission of a vowel, 'elision' can ...

  12. Dentistry and Ayurveda-III (basics - ama, immunity, ojas, rasas, etiopathogenesis and prevention

    Directory of Open Access Journals (Sweden)

    Amruthesh Sunita

    2007-01-01

    Full Text Available This article of the series Dentistry and Ayurveda describes in brief, the basic principlesand unique concepts involved in Ayurveda namely the concepts of Ama, Ojas, Rasas (tastes-types and the factors affecting the choice of the drug / medicine etc., immunity, etiopathogenesis and prevention of diseases in Ayurveda in general.

  13. 汽车仿真软件ADVISOR%Automobile Simulation Software ADVISOR

    Institute of Scientific and Technical Information of China (English)

    刘磊; 刚宪约; 王树凤; 柴山

    2007-01-01

    ADVISOR软件能够快速分析传统汽车、纯电动汽车和混合动力汽车的动力性、燃油经济性以及排放性等各种性能.本文系统地介绍了ADVISOR2002软件的功能特点、仿真策略和操作方法,并对该软件的应用以及汽车性能仿真软件的进一步研制作了展望.

  14. Evaluation of a welfare indicator protocol for assessing animal welfare in AMS herds: researcher, production advisor and veterinary practitioner opinion

    DEFF Research Database (Denmark)

    Rousing, Tine; Jakobsen, Iben Alber; Hindhede, Jens

    2007-01-01

    of the welfare indicator protocol as basis for on-farm welfare assessment have been carried out; one study focused on the opinion of 21 AMS researchers; the other on that of 14 AMS production advisors and 15 veterinary practitioners. The researchers were asked to score the individual welfare relevance of the 38...... measures. Furthermore, both the panels were asked to prioritise the 10 most important measures. The 21 researchers generally appreciated the listed protocol measures as highly relevant. The researcher and advisor panels agreed on prioritised measures from all 4 information sources among the 10 most...... important welfare indicators. In summary, researchers as well as production advisors and veterinarians supported the suggested measures for inclusion in a welfare assessment system. This has demonstrated that integration of different information is considered decisive for operational welfare assessment...

  15. Safety and immunogenicity of an AMA1 malaria vaccine in Malian children: results of a phase 1 randomized controlled trial.

    Directory of Open Access Journals (Sweden)

    Mahamadou A Thera

    Full Text Available BACKGROUND: The objective was to evaluate the safety and immunogenicity of the AMA1-based malaria vaccine FMP2.1/AS02(A in children exposed to seasonal falciparum malaria. METHODOLOGY/PRINCIPAL FINDINGS: A Phase 1 double blind randomized controlled dose escalation trial was conducted in Bandiagara, Mali, West Africa, a rural town with intense seasonal transmission of Plasmodium falciparum malaria. The malaria vaccine FMP2.1/AS02(A is a recombinant protein (FMP2.1 based on apical membrane antigen 1 (AMA1 from the 3D7 clone of P. falciparum, formulated in the Adjuvant System AS02(A. The comparator vaccine was a cell-culture rabies virus vaccine (RabAvert. One hundred healthy Malian children aged 1-6 years were recruited into 3 cohorts and randomized to receive either 10 microg FMP2.1 in 0.1 mL AS02(A, or 25 microg FMP2.1 in 0.25 mL AS02(A, or 50 microg FMP2.1 50 microg in 0.5 mL AS02(A, or rabies vaccine. Three doses of vaccine were given at 0, 1 and 2 months, and children were followed for 1 year. Solicited symptoms were assessed for 7 days and unsolicited symptoms for 30 days after each vaccination. Serious adverse events were assessed throughout the study. Transient local pain and swelling were common and more frequent in all malaria vaccine dosage groups than in the comparator group, but were acceptable to parents of participants. Levels of anti-AMA1 antibodies measured by ELISA increased significantly (at least 100-fold compared to baseline in all 3 malaria vaccine groups, and remained high during the year of follow up. CONCLUSION/SIGNIFICANCE: The FMP2.1/AS02(A vaccine had a good safety profile, was well-tolerated, and induced high and sustained antibody levels in malaria-exposed children. This malaria vaccine is being evaluated in a Phase 2 efficacy trial in children at this site. TRIAL REGISTRATION: ClinicalTrials.gov NCT00358332 [NCT00358332].

  16. An Extended Surface Loop on Toxoplasma gondii Apical Membrane Antigen 1 (AMA1 Governs Ligand Binding Selectivity.

    Directory of Open Access Journals (Sweden)

    Michelle L Parker

    Full Text Available Apicomplexan parasites are the causative agents of globally prevalent diseases including malaria and toxoplasmosis. These obligate intracellular pathogens have evolved a sophisticated host cell invasion strategy that relies on a parasite-host cell junction anchored by interactions between apical membrane antigens (AMAs on the parasite surface and rhoptry neck 2 (RON2 proteins discharged from the parasite and embedded in the host cell membrane. Key to formation of the AMA1-RON2 complex is displacement of an extended surface loop on AMA1 called the DII loop. While conformational flexibility of the DII loop is required to expose the mature RON2 binding groove, a definitive role of this substructure has not been elucidated. To establish a role of the DII loop in Toxoplasma gondii AMA1, we engineered a form of the protein where the mobile portion of the loop was replaced with a short Gly-Ser linker (TgAMA1ΔDIIloop. Isothermal titration calorimetry measurements with a panel of RON2 peptides revealed an influential role for the DII loop in governing selectivity. Most notably, an Eimeria tenella RON2 (EtRON2 peptide that showed only weak binding to TgAMA1 bound with high affinity to TgAMA1ΔDIIloop. To define the molecular basis for the differential binding, we determined the crystal structure of TgAMA1ΔDIIloop in complex with the EtRON2 peptide. When analyzed in the context of existing AMA1-RON2 structures, spatially distinct anchor points in the AMA1 groove were identified that, when engaged, appear to provide the necessary traction to outcompete the DII loop. Collectively, these data support a model where the AMA1 DII loop serves as a structural gatekeeper to selectively filter out ligands otherwise capable of binding with high affinity in the AMA1 apical groove. These data also highlight the importance of considering the functional implications of the DII loop in the ongoing development of therapeutic intervention strategies targeting the AMA1-RON

  17. Expanding the Use of Time-Based Metering: Multi-Center Traffic Management Advisor

    Science.gov (United States)

    Landry, Steven J.; Farley, Todd; Hoang, Ty

    2005-01-01

    Time-based metering is an efficient air traffic management alternative to the more common practice of distance-based metering (or "miles-in-trail spacing"). Despite having demonstrated significant operational benefit to airspace users and service providers, time-based metering is used in the United States for arrivals to just nine airports and is not used at all for non-arrival traffic flows. The Multi-Center Traffic Management Advisor promises to bring time-based metering into the mainstream of air traffic management techniques. Not constrained to operate solely on arrival traffic, Multi-Center Traffic Management Advisor is flexible enough to work in highly congested or heavily partitioned airspace for any and all traffic flows in a region. This broader and more general application of time-based metering is expected to bring the operational benefits of time-based metering to a much wider pool of beneficiaries than is possible with existing technology. It also promises to facilitate more collaborative traffic management on a regional basis. This paper focuses on the operational concept of the Multi-Center Traffic Management Advisor, touching also on its system architecture, field test results, and prospects for near-term deployment to the United States National Airspace System.

  18. Emergence of amae crying in early infancy as a possible social communication tool between infants and mothers.

    Science.gov (United States)

    Nakayama, Hiroko

    2015-08-01

    Amae is defined as "wishing to be loved (Scheidlinger (1999). The Journal of the American Academy of Psychoanalysis, 27(1), p. 91)". Amae crying is known as crying of infants when seeking intimate emotional communication with caregivers. The objective of this study was to delineate when and how amae crying emerges in early infancy. Crying episodes of four infants were observed bimonthly, in the natural context of their homes, from birth to 6 months of age, for approximately 60min per session. Crying episodes (total=275) as determined by two coders were analyzed with respect to several behavioral measures. Results indicated that amae crying emerged at the age of 2 months, and consistently accounted for 30-40% of the total crying episodes after the ages of 3 months. Amae crying could be accurately identified when infants were not in acute discomfort and had already got the attention of their mothers. At such times, infants did not shed tears, cried with a fussy voice, and frequently looked at their mothers. Mothers responded to amae crying more promptly than they did to other types of crying behaviors. It is concluded that 3 months of age, when infants probably begin to use crying as a social communication tool is a major turning point for crying behavior from the perspective of its biological and social roles. It is suggested that amae crying might play an important role in strengthening and encouraging mother-infant interactions. Copyright © 2015 Elsevier Inc. All rights reserved.

  19. Transgene optimization, immunogenicity and in vitro efficacy of viral vectored vaccines expressing two alleles of Plasmodium falciparum AMA1.

    OpenAIRE

    Sumi Biswas; Dicks, Matthew D. J.; Carole A Long; Remarque, Edmond J; Loredana Siani; Stefano Colloca; Cottingham, Matthew G; Holder, Anthony A.; Gilbert, Sarah C.; Hill, Adrian V.S.; Draper, Simon J

    2011-01-01

    BACKGROUND: Apical membrane antigen 1 (AMA1) is a leading candidate vaccine antigen against blood-stage malaria, although to date numerous clinical trials using mainly protein-in-adjuvant vaccines have shown limited success. Here we describe the pre-clinical development and optimization of recombinant human and simian adenoviral (AdHu5 and ChAd63) and orthopoxviral (MVA) vectors encoding transgene inserts for Plasmodium falciparum AMA1 (PfAMA1). METHODOLOGY/PRINCIPAL FINDINGS: AdHu5-MVA prime...

  20. Back to the future: The AMA and religion, 1961-1974.

    Science.gov (United States)

    Kim, Daniel T; Curlin, Farr A; Wolenberg, Kelly M; Sulmasy, Daniel P

    2014-12-01

    U.S. medical scholarship and education regarding religion and spirituality has been growing rapidly in recent years. This rising interest, however, is not new; it is a renewal of significant interweavings that date back to the mid-20th century. In this Perspective, the authors draw attention to the little-known history of organized medicine's engagement with religion from 1961 to 1974. Relying on primary source documents, they recount the dramatic rise and fall of the Committee on Medicine and Religion (CMR) at the American Medical Association (AMA). At its height, there were state-level committees on medicine and religion in 49 states, the District of Columbia, and Puerto Rico, and there were county-level committees in over 800 county medical societies. Thousands of physicians attended annual conferences for clinicians and clergy, and direct outreach to patients included a film viewed by millions. The CMR arose in the context of rapid medical advances, the growth of professional chaplaincy, and concern for declining "humanism" in medicine-conditions with parallels in medicine today. The CMR was brought to a puzzling end in 1972 by the AMA's Board of Trustees. The authors argue that this termination was linked to the AMA's long and contentious debate on abortion. They conclude with the story's significance for today's explorations of the intersection of spirituality, religion, and medicine, focusing on the need for mutual respect, transparency, and dialogue around the needs of patients and physicians.

  1. Menstruation experiences of South African women belonging to the ama-Xhosa ethnic group.

    Science.gov (United States)

    Padmanabhanunni, Anita; Jaffer, Labeeqah; Steenkamp, Jeanette

    2017-09-15

    A growing body of research has emphasised the salience of cultural beliefs and traditional practices to women's experiences of menstruation. Relatively less research has, however, been undertaken in South Africa. This study explored the experience of menstruation among women from the ama-Xhosa ethnic group, one of the largest ethnic groups in the country. Among the ama-Xhosa, there are distinct cultural practices associated with menstruation, including the female rite of passage (intonjane) and virginity testing (inkciyo). However, few studies have explored the experience of menstruation for women from this cultural group. This study involved the synthesis of data from individual interviews and focus group discussions conducted among a sample of ama-Xhosa women. The data were analysed using thematic analysis. Distinctive findings included women's participation in traditional cultural practices of intonjane and inkciyo and the presence of cultural taboos associated with menstruation. Women's narratives revealed strong ambivalence regarding these practices. On the one hand, they wanted to adhere to traditional practices but experienced these customs as evoking discomfort and shame. The study confirmed the prevalence of negative constructions of menstruation. Positive appraisals of menstruation as evoking joy and happiness were also encountered.

  2. ama1 Genes of Sympatric Plasmodium vivax and P. falciparum from Venezuela Differ Significantly in Genetic Diversity and Recombination Frequency

    OpenAIRE

    Ord, RL; Tami, A; Sutherland, CJ

    2008-01-01

    BACKGROUND: We present the first population genetic analysis of homologous loci from two sympatric human malaria parasite populations sharing the same human hosts, using full-length sequences of ama1 genes from Plasmodium vivax and P. falciparum collected in the Venezuelan Amazon. METHODOLOGY/PRINCIPAL FINDINGS: Significant differences between the two species were found in genetic diversity at the ama1 locus, with 18 distinct haplotypes identified among the 73 Pvama1 sequences obtained, compa...

  3. Structure of an IgNAR-AMA1 complex: targeting a conserved hydrophobic cleft broadens malarial strain recognition.

    Science.gov (United States)

    Henderson, Kylie A; Streltsov, Victor A; Coley, Andrew M; Dolezal, Olan; Hudson, Peter J; Batchelor, Adrian H; Gupta, Aditi; Bai, Tao; Murphy, Vincent J; Anders, Robin F; Foley, Michael; Nuttall, Stewart D

    2007-11-01

    Apical membrane antigen 1 (AMA1) is essential for invasion of erythrocytes and hepatocytes by Plasmodium parasites and is a leading malarial vaccine candidate. Although conventional antibodies to AMA1 can prevent such invasion, extensive polymorphisms within surface-exposed loops may limit the ability of these AMA1-induced antibodies to protect against all parasite genotypes. Using an AMA1-specific IgNAR single-variable-domain antibody, we performed targeted mutagenesis and selection against AMA1 from three P. falciparum strains. We present cocrystal structures of two antibody-AMA1 complexes which reveal extended IgNAR CDR3 loops penetrating deep into a hydrophobic cleft on the antigen surface and contacting residues conserved across parasite species. Comparison of a series of affinity-enhancing mutations allowed dissection of their relative contributions to binding kinetics and correlation with inhibition of erythrocyte invasion. These findings provide insights into mechanisms of single-domain antibody binding, and may enable design of reagents targeting otherwise cryptic epitopes in pathogen antigens.

  4. Safety and immunogenicity of multi-antigen AMA1-based vaccines formulated with CoVaccine HT™ and Montanide ISA 51 in rhesus macaques

    Directory of Open Access Journals (Sweden)

    Walraven Vanessa

    2011-07-01

    Full Text Available Abstract Background Increasing the breadth of the functional antibody response through immunization with Plasmodium falciparum apical membrane antigen 1 (PfAMA1 multi-allele vaccine formulations has been demonstrated in several rodent and rabbit studies. This study assesses the safety and immunogenicity of three PfAMA1 Diversity-Covering (DiCo vaccine candidates formulated as an equimolar mixture (DiCo mix in CoVaccine HT™ or Montanide ISA 51, as well as that of a PfAMA1-MSP119 fusion protein formulated in Montanide ISA 51. Methods Vaccine safety in rhesus macaques was monitored by animal behaviour observation and assessment of organ and systemic functions through clinical chemistry and haematology measurements. The immunogenicity of vaccine formulations was assessed by enzyme-linked immunosorbent assays and in vitro parasite growth inhibition assays with three culture-adapted P. falciparum strains. Results These data show that both adjuvants were well tolerated with only transient changes in a few of the chemical and haematological parameters measured. DiCo mix formulated in CoVaccine HT™ proved immunologically and functionally superior to the same candidate formulated in Montanide ISA 51. Immunological data from the fusion protein candidate was however difficult to interpret as four out of six immunized animals were non-responsive for unknown reasons. Conclusions The study highlights the safety and immunological benefits of DiCo mix as a potential human vaccine against blood stage malaria, especially when formulated in CoVaccine HT™, and adds to the accumulating data on the specificity broadening effects of DiCo mix.

  5. 78 FR 57135 - President's Board of Advisors on Historically Black Colleges and Universities

    Science.gov (United States)

    2013-09-17

    ... President's Board of Advisors on Historically Black Colleges and Universities AGENCY: U.S. Department of Education, President's Board of Advisors on Historically Black Colleges and Universities. ACTION: Notice of... President's Board of Advisors on Historically Black Colleges and Universities. The notice also describes...

  6. SADDLE HORSE AND OTHER LIVESTOCK ADVISORS' PERCEPTIONS OF 4-H CLUB WORK IN OHIO.

    Science.gov (United States)

    GROVES, ROBERT H.

    PERCEPTIONS AND UNDERSTANDINGS OF 4-H OBJECTIVES AND PROGRAMS OF 4-H SADDLE HORSE ADVISORS WERE COMPARED WITH THOSE OF OTHER LIVESTOCK ADVISORS IN NORTHEASTERN AND SOUTHWESTERN DISTRICTS OF OHIO. DATA WERE COLLECTED BY QUESTIONNAIRES FROM 90 SADDLE HORSE AND 133 OTHER LIVESTOCK ADVISORS. STATE 4-H STAFF AND SUPERVISORS PROVIDED CORRECT ANSWERS.…

  7. 76 FR 70780 - President's Council of Advisors on Science and Technology

    Science.gov (United States)

    2011-11-15

    ... TECHNOLOGY POLICY President's Council of Advisors on Science and Technology Notice of Meeting: Open Regional Meeting of the President's Council of Advisors on Science and Technology, Working Group on Advanced... open regional meeting of the President's Council of Advisors on Science and Technology (PCAST),...

  8. 77 FR 51790 - President's Council of Advisors on Science and Technology (PCAST)

    Science.gov (United States)

    2012-08-27

    ... President's Council of Advisors on Science and Technology (PCAST) AGENCY: Department of Energy. ACTION... partially closed meeting of the President's Council of Advisors on Science and Technology (PCAST), and...: The President's Council of Advisors on Science and Technology (PCAST) is an advisory group of...

  9. 77 FR 26273 - President's Council of Advisors on Science and Technology (PCAST)

    Science.gov (United States)

    2012-05-03

    ... President's Council of Advisors on Science and Technology (PCAST) AGENCY: Department of Energy. ACTION... partially closed meeting of the President's Council of Advisors on Science and Technology (PCAST), and... INFORMATION: The President's Council of Advisors on Science and Technology (PCAST) is an advisory group of...

  10. 78 FR 59013 - President's Council of Advisors on Science and Technology

    Science.gov (United States)

    2013-09-25

    ... President's Council of Advisors on Science and Technology AGENCY: Department of Energy. ACTION: Notice of... call of the President's Council of Advisors on Science and Technology (PCAST), and describes the... Advisors on Science and Technology (PCAST) is an advisory group of the nation's leading scientists...

  11. 76 FR 70779 - President's Council of Advisors on Science and Technology

    Science.gov (United States)

    2011-11-15

    ... TECHNOLOGY POLICY President's Council of Advisors on Science and Technology Notice of Meeting: Open Regional Meeting of the President's Council of Advisors on Science and Technology, Working Group on Advanced... open regional meeting of the President's Council of Advisors on Science and Technology (PCAST),...

  12. 77 FR 10736 - President's Council of Advisors on Science and Technology (PCAST)

    Science.gov (United States)

    2012-02-23

    ... President's Council of Advisors on Science and Technology (PCAST) AGENCY: Department of Energy, DOE. ACTION... partially closed meeting of the President's Council of Advisors on Science and Technology (PCAST), and.... SUPPLEMENTARY INFORMATION: The President's Council of Advisors on Science and Technology (PCAST) is an...

  13. 78 FR 2259 - President's Council of Advisors on Science and Technology (PCAST)

    Science.gov (United States)

    2013-01-10

    ... President's Council of Advisors on Science and Technology (PCAST) AGENCY: Department of Energy. ACTION... teleconference call of the President's Council of Advisors on Science and Technology (PCAST), and describes the... of Advisors on Science and Technology (PCAST) is an advisory group of the nation's leading...

  14. 75 FR 47317 - President's Council of Advisors on Science and Technology

    Science.gov (United States)

    2010-08-05

    ... TECHNOLOGY POLICY President's Council of Advisors on Science and Technology Notice of Meeting: Partially Closed Meeting of the President's Council of Advisors on Science and Technology. ACTION: Public notice... President's Council of Advisors on Science and Technology (PCAST), and describes the functions of...

  15. 77 FR 38277 - President's Council of Advisors on Science and Technology Meeting

    Science.gov (United States)

    2012-06-27

    ... President's Council of Advisors on Science and Technology Meeting AGENCY: Department of Energy, DoE. ACTION... meeting of the President's Council of Advisors on Science and Technology (PCAST), and describes the... INFORMATION: The President's Council of Advisors on Science and Technology (PCAST) is an advisory group of...

  16. 76 FR 70781 - President's Council of Advisors on Science and Technology

    Science.gov (United States)

    2011-11-15

    ... TECHNOLOGY POLICY President's Council of Advisors on Science and Technology Notice of Meeting: Open Regional Meeting of the President's Council of Advisors on Science and Technology, Working Group on Advanced... open regional meeting of the President's Council of Advisors on Science and Technology (PCAST),...

  17. 75 FR 22635 - President's Council of Advisors on Science and Technology; Meeting

    Science.gov (United States)

    2010-04-29

    ... TECHNOLOGY POLICY President's Council of Advisors on Science and Technology; Meeting Notice of Meeting: Partially Closed Meeting of the President's Council of Advisors on Science and Technology. ACTION: Public... the President's Council of Advisors on Science and Technology (PCAST), and describes the functions...

  18. 17 CFR 4.14 - Exemption from registration as a commodity trading advisor.

    Science.gov (United States)

    2010-04-01

    ... a commodity trading advisor. 4.14 Section 4.14 Commodity and Securities Exchanges COMMODITY FUTURES TRADING COMMISSION COMMODITY POOL OPERATORS AND COMMODITY TRADING ADVISORS General Provisions, Definitions and Exemptions § 4.14 Exemption from registration as a commodity trading advisor. This section...

  19. Functional analysis of the leading malaria vaccine candidate AMA-1 reveals an essential role for the cytoplasmic domain in the invasion process.

    Directory of Open Access Journals (Sweden)

    Moritz Treeck

    2009-03-01

    Full Text Available A key process in the lifecycle of the malaria parasite Plasmodium falciparum is the fast invasion of human erythrocytes. Entry into the host cell requires the apical membrane antigen 1 (AMA-1, a type I transmembrane protein located in the micronemes of the merozoite. Although AMA-1 is evolving into the leading blood-stage malaria vaccine candidate, its precise role in invasion is still unclear. We investigate AMA-1 function using live video microscopy in the absence and presence of an AMA-1 inhibitory peptide. This data reveals a crucial function of AMA-1 during the primary contact period upstream of the entry process at around the time of moving junction formation. We generate a Plasmodium falciparum cell line that expresses a functional GFP-tagged AMA-1. This allows the visualization of the dynamics of AMA-1 in live parasites. We functionally validate the ectopically expressed AMA-1 by establishing a complementation assay based on strain-specific inhibition. This method provides the basis for the functional analysis of essential genes that are refractory to any genetic manipulation. Using the complementation assay, we show that the cytoplasmic domain of AMA-1 is not required for correct trafficking and surface translocation but is essential for AMA-1 function. Although this function can be mimicked by the highly conserved cytoplasmic domains of P. vivax and P. berghei, the exchange with the heterologous domain of the microneme protein EBA-175 or the rhoptry protein Rh2b leads to a loss of function. We identify several residues in the cytoplasmic tail that are essential for AMA-1 function. We validate this data using additional transgenic parasite lines expressing AMA-1 mutants with TY1 epitopes. We show that the cytoplasmic domain of AMA-1 is phosphorylated. Mutational analysis suggests an important role for the phosphorylation in the invasion process, which might translate into novel therapeutic strategies.

  20. Risk Management in College Fraternities: Guidance from Two Faculty Advisors

    Science.gov (United States)

    Rosenberg, Stuart; Mosca, Joseph

    2016-01-01

    Students who become members of fraternities and sororities avail themselves of significant opportunities that enrich their college life. Faculty advisors play an important role in assisting fraternities and sororities in shaping students' leadership, scholastic, and personal development. Given the risks such as alcohol use and hazing that continue…

  1. Full Range Advising: Transforming the Advisor-Advisee Experience

    Science.gov (United States)

    Barbuto, John E., Jr.; Story, Joana S.; Fritz, Susan M.; Schinstock, Jack L.

    2011-01-01

    Drawing from the leadership literature, a new model for advising is proposed. Full range advising encompasses laissez-faire, management by exception, contingent rewards, and transformational behaviors. The relationships between full range advising and advisees' extra effort, satisfaction with the advisor, and advising effectiveness were examined.…

  2. 48 CFR 1403.101-70 - Technical evaluators and advisors.

    Science.gov (United States)

    2010-10-01

    ... GENERAL IMPROPER BUSINESS PRACTICES AND PERSONAL CONFLICTS OF INTEREST Safeguards 1403.101-70 Technical... resolved with the servicing Ethics Counselor. (c) During the evaluation process, each evaluator and advisor... the appearance of conflicting with his or her duty to evaluate proposals impartially and objectively...

  3. Het gebruik van de verzamelde data: de smartphone Eating Advisor

    NARCIS (Netherlands)

    Koenderink, N.J.J.P.; Tireau, A.

    2010-01-01

    De verzamelde data in het Restaurant van de Toekomst is niet alleen te gebruiken voor consumenten-onderzoek. Ook de bezoekers van het restaurant kunnen profiteren van de gegevens voor hun persoonlijke gezondheidsmonitoring. In dit artikel een beschrijving van de smartphone Eating Advisor.

  4. TEACHER-ADVISORS: Where There's a Skill There's A Way.

    Science.gov (United States)

    Tamminen, Armas; And Others

    This report discusses a program to present the Teacher Advisement Training Model. This model for training teacher-advisors is based on the assumption that tentative commitment to making school a more rewarding experience for all is the first step in starting an effective program. The approach is to help teachers learn specific skills and methods…

  5. 75 FR 54465 - Temporary Registration of Municipal Advisors

    Science.gov (United States)

    2010-09-08

    ...: Investments or an investment-related business, or any fraud, false statements, or omissions, ] wrongful taking..., DC 20549 on official business days between the hours of 10 a.m. and 3 p.m. All comments received will... municipal entities, and permits municipal advisors to continue their business after October 1, 2010....

  6. Prokaryotic expression and immunogenicity analysis of bovine Neospora caninum AMA1 gene%牛源犬新孢子虫AMA1基因的原核表达及免疫原性分析

    Institute of Scientific and Technical Information of China (English)

    王华松; 张蕾; 邓梦; 李丽; 郭焕平; 贾立军

    2015-01-01

    为了解牛源犬新孢子虫AMA1基因蛋白特性及免疫原性,本试验以重组质粒PVAX1-NcAMA1为模板,PCR扩增NcAMA1基因,亚克隆至pGEX-4T 1表达载体;表达、纯化NcAMA1重组蛋白,并应用弗氏佐剂制备NcA-MA1重组蛋白亚单位疫苗,接种BALB/c小鼠,间接ELISA方法检测小鼠血清抗体水平,用ELISA方法检测IFN-γ、IL-4表达水平.结果显示,表达的NcAMA1重组蛋白相对分子质量约为94 000(GST约为26 000、NcAMA1约为68 000),NcAMA1重组蛋白亚单位疫苗接种BALB/c小鼠后,能够诱导BALB/c小鼠产生较高的体液免疫水平和细胞免疫水平.本研究为利用该重组蛋白建立免疫学诊断方法及制备抗犬新孢子虫新型亚单位疫苗奠定了基础.

  7. Selection and affinity maturation of IgNAR variable domains targeting Plasmodium falciparum AMA1.

    Science.gov (United States)

    Nuttall, Stewart D; Humberstone, Karen S; Krishnan, Usha V; Carmichael, Jennifer A; Doughty, Larissa; Hattarki, Meghan; Coley, Andrew M; Casey, Joanne L; Anders, Robin F; Foley, Michael; Irving, Robert A; Hudson, Peter J

    2004-04-01

    The new antigen receptor (IgNAR) is an antibody unique to sharks and consists of a disulphide-bonded dimer of two protein chains, each containing a single variable and five constant domains. The individual variable (V(NAR)) domains bind antigen independently, and are candidates for the smallest antibody-based immune recognition units. We have previously produced a library of V(NAR) domains with extensive variability in the CDR1 and CDR3 loops displayed on the surface of bacteriophage. Now, to test the efficacy of this library, and further explore the dynamics of V(NAR) antigen binding we have performed selection experiments against an infectious disease target, the malarial Apical Membrane Antigen-1 (AMA1) from Plasmodium falciparum. Two related V(NAR) clones were selected, characterized by long (16- and 18-residue) CDR3 loops. These recombinant V(NAR)s could be harvested at yields approaching 5mg/L of monomeric protein from the E. coli periplasm, and bound AMA1 with nanomolar affinities (K(D)= approximately 2 x 10(-7) M). One clone, designated 12Y-2, was affinity-matured by error prone PCR, resulting in several variants with mutations mapping to the CDR1 and CDR3 loops. The best of these variants showed approximately 10-fold enhanced affinity over 12Y-2 and was Plasmodium falciparum strain-specific. Importantly, we demonstrated that this monovalent V(NAR) co-localized with rabbit anti-AMA1 antisera on the surface of malarial parasites and thus may have utility in diagnostic applications.

  8. Incorporation of NREL Solar Advisor Model Photovoltaic Capabilities with GridLAB-D

    Energy Technology Data Exchange (ETDEWEB)

    Tuffner, Francis K.; Hammerstrom, Janelle L.; Singh, Ruchi

    2012-10-19

    This report provides a summary of the work updating the photovoltaic model inside GridLAB-D. The National Renewable Energy Laboratory Solar Advisor Model (SAM) was utilized as a basis for algorithms and validation of the new implementation. Subsequent testing revealed that the two implementations are nearly identical in both solar impacts and power output levels. This synergized model aides the system-level impact studies of GridLAB-D, but also allows more specific details of a particular site to be explored via the SAM software.

  9. Identification and localization of minimal MHC-restricted CD8+ T cell epitopes within the Plasmodium falciparum AMA1 protein

    Directory of Open Access Journals (Sweden)

    Sedegah Martha

    2010-08-01

    Full Text Available Abstract Background Plasmodium falciparum apical membrane antigen-1 (AMA1 is a leading malaria vaccine candidate antigen that is expressed by sporozoite, liver and blood stage parasites. Since CD8+ T cell responses have been implicated in protection against pre-erythrocytic stage malaria, this study was designed to identify MHC class I-restricted epitopes within AMA1. Methods A recombinant adenovirus serotype 5 vector expressing P. falciparum AMA1 was highly immunogenic when administered to healthy, malaria-naive adult volunteers as determined by IFN-γ ELISpot responses to peptide pools containing overlapping 15-mer peptides spanning full-length AMA1. Computerized algorithms (NetMHC software were used to predict minimal MHC-restricted 8-10-mer epitope sequences within AMA1 15-mer peptides active in ELISpot. A subset of epitopes was synthesized and tested for induction of CD8+ T cell IFN-γ responses by ELISpot depletion and ICS assays. A 3-dimensional model combining Domains I + II of P. falciparum AMA1 and Domain III of P. vivax AMA1 was used to map these epitopes. Results Fourteen 8-10-mer epitopes were predicted to bind to HLA supertypes A01 (3 epitopes, A02 (4 epitopes, B08 (2 epitopes and B44 (5 epitopes. Nine of the 14 predicted epitopes were recognized in ELISpot or ELISpot and ICS assays by one or more volunteers. Depletion of T cell subsets confirmed that these epitopes were CD8+ T cell-dependent. A mixture of the 14 minimal epitopes was capable of recalling CD8+ T cell IFN-γ responses from PBMC of immunized volunteers. Thirteen of the 14 predicted epitopes were polymorphic and the majority localized to the more conserved front surface of the AMA1 model structure. Conclusions This study predicted 14 and confirmed nine MHC class I-restricted CD8+ T cell epitopes on AMA1 recognized in the context of seven HLA alleles. These HLA alleles belong to four HLA supertypes that have a phenotypic frequency between 23% - 100% in different human

  10. Transgene optimization, immunogenicity and in vitro efficacy of viral vectored vaccines expressing two alleles of Plasmodium falciparum AMA1.

    Directory of Open Access Journals (Sweden)

    Sumi Biswas

    Full Text Available BACKGROUND: Apical membrane antigen 1 (AMA1 is a leading candidate vaccine antigen against blood-stage malaria, although to date numerous clinical trials using mainly protein-in-adjuvant vaccines have shown limited success. Here we describe the pre-clinical development and optimization of recombinant human and simian adenoviral (AdHu5 and ChAd63 and orthopoxviral (MVA vectors encoding transgene inserts for Plasmodium falciparum AMA1 (PfAMA1. METHODOLOGY/PRINCIPAL FINDINGS: AdHu5-MVA prime-boost vaccination in mice and rabbits using these vectors encoding the 3D7 allele of PfAMA1 induced cellular immune responses as well as high-titer antibodies that showed growth inhibitory activity (GIA against the homologous but not heterologous parasite strains. In an effort to overcome the issues of PfAMA1 antigenic polymorphism and pre-existing immunity to AdHu5, a simian adenoviral (ChAd63 vector and MVA encoding two alleles of PfAMA1 were developed. This antigen, composed of the 3D7 and FVO alleles of PfAMA1 fused in tandem and with expression driven by a single promoter, was optimized for antigen secretion and transmembrane expression. These bi-allelic PfAMA1 vaccines, when administered to mice and rabbits, demonstrated comparable immunogenicity to the mono-allelic vaccines and purified serum IgG now showed GIA against the two divergent strains of P. falciparum encoded in the vaccine. CD8(+ and CD4(+ T cell responses against epitopes that were both common and unique to the two alleles of PfAMA1 were also measured in mice. CONCLUSIONS/SIGNIFICANCE: Optimized transgene inserts encoding two divergent alleles of the same antigen can be successfully inserted into adeno- and pox-viral vaccine vectors. Adenovirus-MVA immunization leads to the induction of T cell responses common to both alleles, as well as functional antibody responses that are effective against both of the encoded strains of P. falciparum in vitro. These data support the further clinical

  11. Computational and biophysical approaches to protein-protein interaction inhibition of Plasmodium falciparum AMA1/RON2 complex

    Science.gov (United States)

    Pihan, Emilie; Delgadillo, Roberto F.; Tonkin, Michelle L.; Pugnière, Martine; Lebrun, Maryse; Boulanger, Martin J.; Douguet, Dominique

    2015-06-01

    Invasion of the red blood cell by Plasmodium falciparum parasites requires formation of an electron dense circumferential ring called the Moving Junction (MJ). The MJ is anchored by a high affinity complex of two parasite proteins: Apical Membrane Antigen 1 ( PfAMA1) displayed on the surface of the parasite and Rhoptry Neck Protein 2 that is discharged from the parasite and imbedded in the membrane of the host cell. Structural studies of PfAMA1 revealed a conserved hydrophobic groove localized to the apical surface that coordinates RON2 and invasion inhibitory peptides. In the present work, we employed computational and biophysical methods to identify competitive P. falciparum AMA1-RON2 inhibitors with the goal of exploring the `druggability' of this attractive antimalarial target. A virtual screen followed by molecular docking with the PfAMA1 crystal structure was performed using an eight million compound collection that included commercial molecules, the ChEMBL malaria library and approved drugs. The consensus approach resulted in the selection of inhibitor candidates. We also developed a fluorescence anisotropy assay using a modified inhibitory peptide to experimentally validate the ability of the selected compounds to inhibit the AMA1-RON2 interaction. Among those, we identified one compound that displayed significant inhibition. This study offers interesting clues to improve the throughput and reliability of screening for new drug leads.

  12. Enhanced antibody production in mice to the malaria antigen AMA1 by CPG 7909 requires physical association of CpG and antigen

    OpenAIRE

    Mullen, Gregory E. D.; Aebig, Joan A.; Dobrescu, Gelu; Rausch, Kelly; Lambert, Lynn; Long, Carole A.; Miles, Aaron P.; Saul, Allan

    2007-01-01

    CpG oligodeoxynucleotides are potent immunostimulants. In this study, CPG 7909 was formulated with the recombinant Plasmodium falciparum protein AMA1-C1 adsorbed to Alhydrogel (aluminum hydroxide) and used to immunize mice. Mice receiving free CPG 7909 in a separate same site injection to the AMA1-C1/Alhydrogel had the same antibody responses as mice receiving AMA1-C1/Alhydrogel alone. For mice immunized with CPG 7909 bound to the AMA1-C1/Alhydrogel formulation, there was a bell shaped CPG 79...

  13. Protective effect of a prime-boost strategy with plasmid DNA followed by recombinant adenovirus expressing TgAMA1 as vaccines against Toxoplasma gondii infection in mice.

    Science.gov (United States)

    Yu, Longzheng; Yamagishi, Junya; Zhang, Shoufa; Jin, Chunmei; Aboge, Gabriel Oluga; Zhang, Houshuang; Zhang, Guohong; Tanaka, Tetsuya; Fujisaki, Kozo; Nishikawa, Yoshifumi; Xuan, Xuenan

    2012-09-01

    A heterologous prime-boost strategy with priming plasmid DNA followed by recombinant virus expressing relevant antigens is known to stimulate protective immunity against intracellular parasites. In this study, we have evaluated a heterologous prime-boost strategy for immunizing mice against Toxoplasma gondii infection. Our results revealed that the prime-boost strategy using both plasmid DNA and adenoviral vector encoding TgAMA1 may stimulate both humoral and Th1/Th2 cellular immune responses specific for TgAMA1. Moreover, C57BL/6 mice immunized with the pAMA1/Ad5Null, pNull/Ad5AMA1, and pAMA1/Ad5AMA1 constructs showed survival rates of 12.5%, 37.5%, and 50%, respectively. In contrast, all the pNull/Ad5Null immunized mice died after infection with the PLK-GFP strain of T. gondii. Brain cyst burden was reduced by 23% in mice immunized with pAMA1/Ad5AMA1 compared with the pNull/Ad5AMA1 immunized mice. These results demonstrate that the heterologous DNA priming and recombinant adenovirus boost strategy may provide protective immunity against T. gondii infection.

  14. The Green Building Advisor: Design team on a disc

    Energy Technology Data Exchange (ETDEWEB)

    Malin, N. [Environmental Building News, Brattleboro, VT (United States)

    1998-12-01

    A tool intended to educate building designers and contractors, called the {sup G}reen Building Advisor` is described. The Green Building Advisor is an educational and professional software tool for architects and designers to help them create environmentally friendly and healthy buildings. The program solicits information about the user`s project, searches a database of environmental knowledge and case studies, and presents the user with a prioritized list of relevant design strategies. The program functions by responding to the user`s information with context-sensitive, customized information organized under topic areas ( envelope, lighting, windows, HVAC, equipment, etc) based on the area of their environmental impact (indoor environment, energy, water, resources and materials and other ecosystem impacts). Detailed information on each strategy is provided. The program also includes a series of case studies from across North America, selected to represent a broad range in terms of building size, type, and climate region. 4 figs.

  15. Construction and Implementation of Monitoring System for Internal Soundness of College Advisors Training Base%高校辅导员培训基地内部质量监控体系的构建与实施——针对辅导员培训的讨论

    Institute of Scientific and Technical Information of China (English)

    陈洁

    2011-01-01

    构建并实施高校辅导员培训基地内部质量监控体系,对于提高辅导员培训质量具有积极作用。监控的对象包括培训方案设计、培训过程实施和学员的培训效果;监控的方式有督导检查、学员评议和跟踪回访;监控的实施包括基地办公室、班主任和小组联络员三个层次。%Construction and implementation of monitoring system for internal soundness of college advisors training base plays a positive role in improving the training quality. Objects of monitoring include the project design, the process and the result. It is carried out on three levels, i.e. the Base Office, the head teacher and the team liaison, by means of inspection, trainee appraisal and return visits.

  16. Prevalence of Dementia and Mild Cognitive Impairment in the Rural Island Town of Ama-cho, Japan

    Directory of Open Access Journals (Sweden)

    Kenji Wada-Isoe

    2012-04-01

    Full Text Available Aims: In order to determine the prevalence of dementia and mild cognitive impairment (MCI, we conducted a population-based study in Japan. Methods: Participants included 924 subjects aged 65 years or older who resided in the town of Ama-cho. In phase 1 of the study, the Mini-Mental State Examination and Clinical Dementia Rating were administered for screening purposes. In phase 2 of the study, the subjects who screened positive were further examined by neurologists. Dementia and MCI were diagnosed by means of DSM-IV and International Working Group on MCI criteria, respectively. Results: By the prevalence date of June 1, 2010, 24 subjects had deceased or lived outside the town. In total, 723 of the remaining 900 subjects received a phase 1 test. In phase 2, 98 subjects were diagnosed with amnestic MCI, 113 subjects with non-amnestic MCI, and 82 subjects with dementia. Of the subjects who did not receive the phase 1 test, 66 subjects were diagnosed as having dementia according to data from their town medical card or the Long-term Care Insurance System. The crude prevalence of amnestic MCI, non-amnestic MCI, and dementia were 10.9, 12.6, and 16.4%, respectively. Conclusion: Consistent with the striking increase in the number of elderly individuals, we report higher prevalence of MCI and dementia in Japan than previously described.

  17. A Workflow-based Intelligent Network Data Movement Advisor with End-to-end Performance Optimization

    Energy Technology Data Exchange (ETDEWEB)

    Zhu, Michelle M. [Southern Illinois Univ., Carbondale, IL (United States); Wu, Chase Q. [Univ. of Memphis, TN (United States)

    2013-11-07

    Next-generation eScience applications often generate large amounts of simulation, experimental, or observational data that must be shared and managed by collaborative organizations. Advanced networking technologies and services have been rapidly developed and deployed to facilitate such massive data transfer. However, these technologies and services have not been fully utilized mainly because their use typically requires significant domain knowledge and in many cases application users are even not aware of their existence. By leveraging the functionalities of an existing Network-Aware Data Movement Advisor (NADMA) utility, we propose a new Workflow-based Intelligent Network Data Movement Advisor (WINDMA) with end-to-end performance optimization for this DOE funded project. This WINDMA system integrates three major components: resource discovery, data movement, and status monitoring, and supports the sharing of common data movement workflows through account and database management. This system provides a web interface and interacts with existing data/space management and discovery services such as Storage Resource Management, transport methods such as GridFTP and GlobusOnline, and network resource provisioning brokers such as ION and OSCARS. We demonstrate the efficacy of the proposed transport-support workflow system in several use cases based on its implementation and deployment in DOE wide-area networks.

  18. Evaluation of a welfare indicator protocol for assessing animal welfare in AMS herds: researcher, production advisor and veterinary practitioner opinion

    DEFF Research Database (Denmark)

    Rousing, Tine; Jakobsen, Iben Alber; Hindhede, Jens

    2007-01-01

    of the welfare indicator protocol as basis for on-farm welfare assessment have been carried out; one study focused on the opinion of 21 AMS researchers; the other on that of 14 AMS production advisors and 15 veterinary practitioners. The researchers were asked to score the individual welfare relevance of the 38......A welfare indicator protocol integrating a total of 38 measures from 4 information sources: housing system, management, animal behaviour and clinical health has been developed for decision support in Automatic Milking System (AMS) herds. Two expert opinion studies focusing on the relevance...... measures. Furthermore, both the panels were asked to prioritise the 10 most important measures. The 21 researchers generally appreciated the listed protocol measures as highly relevant. The researcher and advisor panels agreed on prioritised measures from all 4 information sources among the 10 most...

  19. An integrative review of community health advisors in type 2 diabetes.

    Science.gov (United States)

    Hunt, Caralise W; Grant, Joan S; Appel, Susan J

    2011-10-01

    The purpose of this paper was to report findings from an integrative literature review conducted to identify the theoretical basis of interventions for studies using community health advisors; populations and settings served by community health advisors; characteristics, training, and roles and activities of community health advisors; and the effectiveness of interventions by community health advisors for improving self-management of patients living with type 2 diabetes mellitus. Community health advisors' theoretical interventions were based on providing culturally appropriate care and resolution of health disparities within minority populations. Typically community health advisors were patients themselves living with type 2 diabetes mellitus. Major roles of community health advisors included: supporter, educator, case manager, advocate, and program facilitator. Activities of community health advisors were: coordinating educational programs, conducting educational courses for patients, serving as a link between patients and healthcare professionals, providing counseling, and leading peer support meetings. The effectiveness of interventions by community health advisors was mixed. Examples of outcome criteria were improvements in: knowledge, hemoglobin A1C, low density lipoprotein levels, blood pressure, and physical activity. Community health advisors provide culturally appropriate interventions to promote and restore health and prevent diseases while serving as links between community and healthcare providers.

  20. A Pervasive Social Networking Application: I-NFC enabled Florist Smart Advisor

    Science.gov (United States)

    Swee Wen, Khoo; Mahinderjit Singh, Manmeet

    2016-11-01

    Location based service is an information and entertainment service, accessible with mobile devices through the mobile network and utilizing the ability to make use of the geographical position of the mobile device. NFC location based service is using one of the modes of NFC such as peer-to-peer, reader/writer, and card emulation to obtain the information of the object and then get the location of the object. In this paper, the proposed solution is I- NFC-enabled Pervasive Social Networking apps for florists. It combines the NFC location based service with Online Social Network (OSN). In addition, a smart advisor in the system to provide output in making their own decision while purchasing products.The development of the system demonstrates that a designed commerce site is provided which enable a communication between NFC-enabled smartphone, NFC-enabled application and OSN. GPS functionalities also implemented to provide map and location of business services. Smart advisor also designed to provide information for users who do not have ideas what to purchase.

  1. Chester: towards a personal medication advisor.

    Science.gov (United States)

    Allen, James; Ferguson, George; Blaylock, Nate; Byron, Donna; Chambers, Nathanael; Dzikovska, Myroslava; Galescu, Lucian; Swift, Mary

    2006-10-01

    Dialogue systems for health communication hold out the promise of providing intelligent assistance to patients through natural interfaces that require no training to use. But in order to make the development of such systems cost effective, we must be able to use generic techniques and components which are then specialized as needed to the specific health problem and patient population. In this paper, we describe Chester, a prototype intelligent assistant that interacts with its user via conversational natural spoken language to provide them with information and advice regarding their prescribed medications. Chester builds on our prior experience constructing conversational assistants in other domains. The emphasis of this paper is on the portability of our generic spoken dialogue technology, and presents a case study of the application of these techniques to the development of a dialogue system for health communication.

  2. Automated Advisors for Remote Science Experimentation

    Science.gov (United States)

    Frainier, Richard; Groleau, Nicolas; Hazelton, Lyman; Colombano, Silvano

    1994-01-01

    This paper details flight results from the PI-in-a-Box project. The project is an attempt to understand the issues involved in building automated real-time advisory systems to improve the conduct of science in remote laboratory settings. This is an important problem as examples of these situations can be found throughout aerospace. A knowledge-based approach is used to facilitate real-time reactions to experiment data as it is collected by a competent, but not expert, operator. The system was flown on the Space Shuttle in October, 1993. The PI-in-a-Box system was able to outperform humans in a variety of science-related tasks. These tasks include data integrity assurance, data analysis, and scientific model validation.

  3. A randomized and controlled Phase 1 study of the safety and immunogenicity of the AMA1-C1/Alhydrogel + CPG 7909 vaccine for Plasmodium falciparum malaria in semi-immune Malian adults.

    Science.gov (United States)

    Sagara, Issaka; Ellis, Ruth D; Dicko, Alassane; Niambele, Mohamed B; Kamate, Beh; Guindo, Ousmane; Sissoko, Mahamadou S; Fay, Michael P; Guindo, Merepen A; Kante, Ousmane; Saye, Renion; Miura, Kazutoyo; Long, Carole; Mullen, Gregory E D; Pierce, Mark; Martin, Laura B; Rausch, Kelly; Dolo, Amagana; Diallo, Dapa A; Miller, Louis H; Doumbo, Ogobara K

    2009-12-09

    A double blind, randomized and controlled Phase 1 clinical trial was conducted to assess the safety and immunogenicity in malaria-exposed adults of the Plasmodium falciparum blood stage vaccine candidate Apical Membrane Antigen 1-Combination 1 (AMA1-C1)/Alhydrogel with and without the novel adjuvant CPG 7909. Participants were healthy adults 18-45 years old living in the village of Donéguébougou, Mali. A total of 24 participants received 2 doses one month apart of either 80 microg AMA1-C1/Alhydrogel or 80 microg AMA1-C1/Alhydrogel + 564 microg CPG 7909. The study started in October 2007 and completed follow up in May 2008. Both vaccines were well tolerated, with only mild local adverse events and no systemic adverse events judged related to vaccination. The difference in antibody responses were over 2-fold higher in the group receiving CPG 7909 for all time points after second vaccination and the differences are statistically significant (all pCPG 7909 in a malaria-exposed population.

  4. Mixed-Initiative COA Critic Advisors (MICCA)

    Science.gov (United States)

    2013-02-01

    a domain independent manner, and communicate via a blackboard framework. Domain dependent information is utilized to support some of their reasoning...Evaluation, Planning, Case Based Reasoning, Blackboard Systems, Hierarchical Task Networks, Quantitative Temporal Reasoning, Preference Model 16. SECURITY...execution. The MICCA agents operate in a domain independent framework, communicate through a blackboard , and utilize domain dependent information to

  5. Enhanced antibody production in mice to the malaria antigen AMA1 by CPG 7909 requires physical association of CpG and antigen.

    Science.gov (United States)

    Mullen, Gregory E D; Aebig, Joan A; Dobrescu, Gelu; Rausch, Kelly; Lambert, Lynn; Long, Carole A; Miles, Aaron P; Saul, Allan

    2007-07-20

    CpG oligodeoxynucleotides are potent immunostimulants. In this study, CPG 7909 was formulated with the recombinant Plasmodium falciparum protein AMA1-C1 adsorbed to Alhydrogel (aluminum hydroxide) and used to immunize mice. Mice receiving free CPG 7909 in a separate same site injection to the AMA1-C1/Alhydrogel had the same antibody responses as mice receiving AMA1-C1/Alhydrogel alone. For mice immunized with CPG 7909 bound to the AMA1-C1/Alhydrogel formulation, there was a bell shaped CPG 7909 dose-response curve with the highest antibody response co-incident with the concentration of CPG 7909 that saturated binding to the Alhydrogel. At a higher CPG 7909 dose where 74% was unbound, there was no enhancement of response over AMA1-C1/Alhydrogel alone. Our results suggest that the adjuvant effects of CpGs are optimal when adsorbed to Alhydrogel and highlight the need for careful characterization of the vaccine formulation.

  6. Vozači starije životne dobi u prometnim nesrećama

    OpenAIRE

    Bilban, Marjan

    2003-01-01

    Brojni su čimbenici pridonijeli porastu broja starijih ljudi u razvijenim društvima. Pri tome se susrećemo i s rastućim udjelom starijih vozača – vozača sa svim bolestima i teškoćama što ih donosi starost. Strukturalne i funkcionalne promjene u vrijeme starenja već fiziološki dovode do slabljenja percepcije. Kod starijih osoba važni su također mišićno–koštani problemi, pad intelektualnih funkcija, a isto tako i usporavanje psihomotoričkih funkcija – produžava se npr. reakcijska brzina. U istr...

  7. Impact of student reflective e-portfolio on medical student advisors.

    Science.gov (United States)

    Bashook, Philip G; Gelula, Mark H; Joshi, Medha; Sandlow, Leslie J

    2008-01-01

    Little is published about the role of faculty advisors and use of students' e-portfolios. This article reports advisors' observations and understanding about 1st-year students based on information from students' journaling as part of an e-portfolio. Data were collected on Blackboard survey module for 8 volunteer advisors at two medical school campuses. Responses were hand coded, verified by two authors, tallied, with example comments recorded. The four male and four female advisors are all mid-career, mixed between clinical and nonclinical faculty. The students' responses in the portfolio gave advisors greater insight into students' thinking, maturity, and reflective ability, and they helped advisors identify early warnings about problems. The e-portfolio enhanced meaningful interactions and more focused discussions with students. Advisors reported no improvements in efficiency of communications and had technical difficulties with Blackboard (version 6.0). Advisors reported students' reflective responses to focused questions in an e-portfolio contribute valuable understanding about students' thinking and attitudes. Advisors are enthusiastic about the value of the e-portfolio for this purpose. We anticipate benefits will generalize when fully implemented.

  8. ION-EXCHANGE IMMUNOAFFINITY PURIFICATION OF A RECOMBINANT BACULOVIRUS PLASMODIUM-FALCIPARUM APICAL MEMBRANE ANTIGEN, PF83/AMA-1

    NARCIS (Netherlands)

    NARUM, DL; WELLING, GW; THOMAS, AW

    1993-01-01

    A two-step purification regime has been developed for a quantitatively minor, putatively transmembrane, M(r) 83 000, apical membrane blood stage vaccine candidate antigen of Plasmodium falciparum (PF83/AMA-1), that has been expressed as a full-length baculovirus recombinant protein, PF83-FG8-1. The

  9. alpha-Thalassaemia trait is associated with Antibody prevalence against Malaria Antigens AMA-1 and MSP-1

    NARCIS (Netherlands)

    Daou, M; Kituma, E.; Kavishe, R.A.; Chilongola, J.; Mosha, F.; Ven, A.J. van der; Kouriba, B.; Bousema, T.; Sauerwein, R.W.; Doumbo, O.

    2015-01-01

    A longitudinal study was conducted in a low endemic area in northern Tanzania to examine the influence of the alpha-thalassaemia trait on malaria incidence and antibody responses to malaria apical membrane antigen-1 (AMA-1) and merozoite surface protein1-19 (MSP-119). Out of 394 children genotyped f

  10. Analysis of polymorphisms and selective pressures on ama1 gene in Plasmodium knowlesi isolates from Sabah, Malaysia

    Indian Academy of Sciences (India)

    CHUEN YANG CHUA; PINGCHIN LEE; TIEK YING LAU

    2017-09-01

    The apical membrane antigen-1 (AMA-1) of Plasmodium spp. is a merozoite surface antigen that is essential for the recognition and invasion of erythrocytes. Polymorphisms occurring in this surface antigen will cause major obstacles in developing effective malaria vaccines based on AMA-1. The objective of this study was to characterize ama1 gene in Plasmodium knowlesi isolates from Sabah. DNA was extracted from blood samples collected from Keningau, Kota Kinabalu and Kudat. The Pkama1 gene was amplified using nested PCR and subjected to bidirectional sequencing. Analysis of DNA sequence revealed that most of the nucleotide polymorphisms were synonymous and concentrated in domain I of PkAMA-1. Forteen haplotypes were identified based on amino acid variations and haplotype K5 was the most common haplotype. dN/dS ratios implied that purifying selection was prevalent in Pkama1 gene. Fu and Li’s D and F values further provided evidence of negative selection acting on domain II ofPkama1. Lownucleotide diversitywas also detected for the Pkama1 sequences,which is similar to reports on Pkama1 from Peninsular Malaysia and Sarawak. The presence of purifying selection and low nucleotide diversity indicated that domain II of Pkama1 can be used as a target for vaccine development.

  11. From Diagnosis to Action: An Automated Failure Advisor for Human Deep Space Missions

    Science.gov (United States)

    Colombano, Silvano; Spirkovska, Lilly; Baskaran, Vijayakumar; Morris, Paul; Mcdermott, William; Ossenfort, John; Bajwa, Anupa

    2015-01-01

    The major goal of current space system development at NASA is to enable human travel to deep space locations such as Mars and asteroids. At that distance, round trip communication with ground operators may take close to an hour, thus it becomes unfeasible to seek ground operator advice for problems that require immediate attention, either for crew safety or for activities that need to be performed at specific times for the attainment of scientific results. To achieve this goal, major reliance will need to be placed on automation systems capable of aiding the crew in detecting and diagnosing failures, assessing consequences of these failures, and providing guidance in repair activities that may be required. We report here on the most current step in the continuing development of such a system, and that is the addition of a Failure Response Advisor. In simple terms, we have a system in place the Advanced Caution and Warning System (ACAWS) to tell us what happened (failure diagnosis) and what happened because that happened (failure effects). The Failure Response Advisor will tell us what to do about it, how long until something must be done and why its important that something be done and will begin to approach the complex reasoning that is generally required for an optimal approach to automated system health management. This advice is based on the criticality and various timing elements, such as durations of activities and of component repairs, failure effects delay, and other factors. The failure advice is provided to operators (crew and mission controllers) together with the diagnostic and effects information. The operators also have the option to drill down for more information about the failure and the reasons for any suggested priorities.

  12. Comparative analysis of the tools 'Retrofit Advisor' and 'EPIQR+' - Final report; Analisi comparativa degli strumenti 'Retrofit Advisor' e 'EPIQR+' - Rapporto finale

    Energy Technology Data Exchange (ETDEWEB)

    Pittet, D.; Ghirlanda, L.

    2008-07-01

    This report represents the final phase of Swiss Federal Office of Energy project 'Strategy for long-term management of city-owned real estate - the case of the City Council of Chiasso'. It contains a comparative analysis of two tools for the evaluation of the potential for retrofitting and refurbishment of buildings (Retrofit Advisor and Epiqr+). By applying the two tools in parallel, it was possible to compare information and data obtained, and also to obtain indications for the evaluation of the usability of the tools. To achieve this, five buildings in the territory of the city of Chiasso were submitted to the tools for analysis. The applications have highlighted the usability of each case study. The ease of use of Retrofit Advisor has allowed the evaluation of each proposed scenario; by using the same reference system, comparable data are obtained (at indication level) to support the choice of the intervention strategy on existing buildings. In addition to the analysis of the current status, the tool Retrofit Advisor supports a structure analysis over three intervention scenarios, namely reparation, renovation, rebuild. Data entry does not require advanced knowledge of construction work, and is limited to basic characteristics. The analysis performed through Epiqr+ is more rigorous, providing a specific and detailed diagnosis on the state of deterioration of each construction element, supported by a series of intervention suggestions. The Epiqr+ tool has furthermore allowed the evaluation (within a precision range of {+-}15%) the cost of reparation/renovation works, and also the thermal energy balance of each building, based on the characteristics of their envelops. On the basis of contents criteria and cost analysis, the approach has allowed the evaluation of different options for the improvement of the buildings, from simple reparation to total rebuild. Estimates are evaluated in terms of cost, of environmental impact, and, in the case of Retrofit

  13. 78 FR 77175 - Catalyst Capital Advisors LLC and Mutual Fund Series Trust; Notice of Application

    Science.gov (United States)

    2013-12-20

    ... COMMISSION Catalyst Capital Advisors LLC and Mutual Fund Series Trust; Notice of Application December 16... agreements without shareholder approval. APPLICANTS: Catalyst Capital Advisors LLC (``CCA'' or the ``Adviser'') and Mutual Fund Series Trust (formerly Catalyst Funds) (the ``Trust''). DATES: Filing Dates:...

  14. 78 FR 14297 - President's Board of Advisors on Historically Black Colleges and Universities

    Science.gov (United States)

    2013-03-05

    ... President's Board of Advisors on Historically Black Colleges and Universities AGENCY: U.S. Department of... Black Colleges and Universities scheduled for March 6, 2013, and announced in the Federal Register on... Advisors on Historically Black Colleges and Universities, U.S. Department of Education, 400 Maryland...

  15. A Training Program for College Residence Hall Advisors: Rincon Hall, California State University, Northridge.

    Science.gov (United States)

    Matthias, Ruth

    This program was devised in an attempt to train more effective resident advisors for the 1972-73 school year at a dormitory at California State University. The special characteristics of the dormitory--racially mixed and discordant--seemed to indicate a need for a special kind of resident advisor training program, one that attempted to better…

  16. 75 FR 56055 - Advisory Committee and Species Working Group Technical Advisor Appointments

    Science.gov (United States)

    2010-09-15

    ... National Oceanic and Atmospheric Administration RIN 0648-XY91 Advisory Committee and Species Working Group... soliciting nominations for technical advisors to the Advisory Committee's species working groups. DATES... technical advisors to a species working group should be sent to Ms. Rachel O'Malley, Office of...

  17. Industrial-Organizational and Human Factors Graduate Program Admission: Information for Undergraduate Advisors

    Science.gov (United States)

    Shoenfelt, Elizabeth L.; Stone, Nancy J.; Kottke, Janet L.

    2015-01-01

    Many psychology departments do not have industrial-organizational (IO) or human factors (HF) faculty members. As such, potential IO and HF graduate students may miss career opportunities because faculty advisors are unfamiliar with the disciplines and their graduate programs. To assist advisors, this article highlights the content of IO and HF…

  18. Explaining Doctoral Students' Relational Maintenance with Their Advisor: A Psychosocial Development Perspective

    Science.gov (United States)

    Goldman, Zachary W.; Goodboy, Alan K.

    2017-01-01

    This study explored how psychosocial development affects doctoral students' relationship and communication with their advisor. Chickering and Reisser's vectors of psychosocial development were examined in the doctoral context to understand how students preserve communicatively satisfying relationships with their advisor through the use of…

  19. GSA Advisors' Self-Efficacy Related to LGBT Youth of Color and Transgender Youth

    Science.gov (United States)

    Poteat, V. Paul; Scheer, Jillian R.

    2016-01-01

    Gay-Straight Alliances (GSAs) serve lesbian, gay, bisexual, transgender (LGBT) and heterosexual youth from diverse backgrounds. Although some attention has been given to youth members in general, little attention has been given to adult advisors. Among 47 GSA advisors from 33 high schools (39 cisgender female, 8 cisgender male), the authors…

  20. The Development of an International Student Advisor: A Grounded Theory Study

    Science.gov (United States)

    Sparaco, Kathleen Keenan

    2012-01-01

    This qualitative study explored the professional experience of international student advisors. The statement of problem for this research was that the professional role of international student advisors has not been clearly defined or understood within U.S. higher education. The research questions asked (1) what encompassed the lived experience of…

  1. Explaining Doctoral Students' Relational Maintenance with Their Advisor: A Psychosocial Development Perspective

    Science.gov (United States)

    Goldman, Zachary W.; Goodboy, Alan K.

    2017-01-01

    This study explored how psychosocial development affects doctoral students' relationship and communication with their advisor. Chickering and Reisser's vectors of psychosocial development were examined in the doctoral context to understand how students preserve communicatively satisfying relationships with their advisor through the use of…

  2. Mentoring Support and Relational Uncertainty in the Advisor-Advisee Relationship

    Science.gov (United States)

    Mansson, Daniel H.; Myers, Scott A.

    2013-01-01

    We examine the extent to which career mentoring and psychosocial mentoring received from their advisors relates to advisee perceptions of advisor-advisee relational uncertainty. Doctoral students (N = 378) completed the "Academic Mentoring Behaviors Scale" (Schrodt, Cawyer, & Sanders, 2003), the "Mentoring and Communication…

  3. Mentoring Support and Relational Uncertainty in the Advisor-Advisee Relationship

    Science.gov (United States)

    Mansson, Daniel H.; Myers, Scott A.

    2013-01-01

    We examine the extent to which career mentoring and psychosocial mentoring received from their advisors relates to advisee perceptions of advisor-advisee relational uncertainty. Doctoral students (N = 378) completed the "Academic Mentoring Behaviors Scale" (Schrodt, Cawyer, & Sanders, 2003), the "Mentoring and Communication…

  4. 77 FR 25210 - Advisors Series Trust and Orinda Asset Management, LLC; Notice of Application

    Science.gov (United States)

    2012-04-27

    ... 15(a) of the Act and rule 18f-2 under the Act, as well as from certain disclosure requirements... disclosure requirements. APPLICANTS: Advisors Series Trust (the ``Trust'') and Orinda Asset Management, LLC... continuous investment program for each Fund. The Advisor will provide the Funds with overall management...

  5. Student Organization Advisor Motives to Volunteer at Four-Year Institutions of Higher Education

    Science.gov (United States)

    Meyer, Robert A.; Kroth, Michael

    2010-01-01

    Many higher education institutions require student organization advisors to be employees. Such requirements can be interpreted as barriers to students and can limit the number and types of groups found on college campuses. Using quantitative analysis, this study investigates the motivation of student organization advisors at six public…

  6. 76 FR 30323 - President's Board of Advisors on Historically Black Colleges and Universities

    Science.gov (United States)

    2011-05-25

    ... sets forth the schedule and agenda of the meeting of the President's Board of Advisors on Historically.... Agenda The Board will receive updates from the Chairman of the President's Board of Advisors on HBCUs and... support of HBCUs in Fiscal Years 2010 and 2011, the budget outlook for federal support in Fiscal Year...

  7. The Advisor and Instructor as a Dynamic Duo: Academic Motivation and Basic Psychological Needs

    Science.gov (United States)

    Burt, Tracie D.; Young-Jones, Adena D.; Yadon, Carly A.; Carr, Michael T.

    2013-01-01

    Students learn in and out of a formal classroom, and instructors and academic advisors play key roles in academic motivation and learning. Therefore, through the lens of self-determination theory, we examined the ways perceived support from instructors and advisors relates to satisfaction of college students' basic psychological needs.…

  8. 75 FR 80045 - Federal Advisory Committee Act; Board of Advisors Charter Renewal

    Science.gov (United States)

    2010-12-21

    ... COMMISSION Federal Advisory Committee Act; Board of Advisors Charter Renewal AGENCY: Election Assistance Commission. ACTION: Notice of Charter Renewal. SUMMARY: In accordance with the Federal Advisory Committee Act... (EAC) has renewed the charter for the Board of Advisors for a two-year period through December 14,...

  9. Working with Youth on LGBT Issues: Why Gay-Straight Alliance Advisors Become Involved

    Science.gov (United States)

    Valenti, Maria; Campbell, Rebecca

    2009-01-01

    This phenomenological qualitative study explores motivation for citizen participation in a local context by exploring the experiences of Gay-Straight Alliance (GSA) club advisors from public high schools. Fourteen advisors from one midwestern state were randomly recruited for participation. Inductive and deductive qualitative analyses elucidated…

  10. A Cross-Cultural Relationship between the Advisor and the Advisee: Dissertation Writing Supervision in Science.

    Science.gov (United States)

    Dong, Yu Ren

    A study examined the supervisory relationship between a non-native English-speaking doctoral student and a native English-speaking advisor, particularly in science, focusing on factors leading to effective or ineffective supervision, advisee response to advisor guidance and assistance, and the roles played by the two participants. Subjects were…

  11. 76 FR 72224 - President's Council of Advisors on Science and Technology Meeting

    Science.gov (United States)

    2011-11-22

    ... TECHNOLOGY POLICY President's Council of Advisors on Science and Technology Meeting AGENCY: Office of Science... summary agenda for a conference call of the President's Council of Advisors on Science and Technology... report on undergraduate science, technology, engineering, and mathematics (STEM) education. DATES:...

  12. 77 FR 18798 - President's Council of Advisors on Science and Technology (PCAST)

    Science.gov (United States)

    2012-03-28

    ... President's Council of Advisors on Science and Technology (PCAST) AGENCY: Department of Energy, Office of... agenda for an open conference call of the President's Council of Advisors on Science and Technology... President to augment the science and technology advice available to him from inside the White House and...

  13. 76 FR 75919 - President's Council of Advisors on Science and Technology Meeting

    Science.gov (United States)

    2011-12-05

    ... TECHNOLOGY POLICY President's Council of Advisors on Science and Technology Meeting AGENCY: Office of Science... Council of Advisors on ] Science and Technology (PCAST) is an advisory group of the nation's leading scientists and engineers, appointed by the President to augment the science and technology advice...

  14. 78 FR 35617 - President's Council of Advisors on Science and Technology (PCAST)

    Science.gov (United States)

    2013-06-13

    ... President's Council of Advisors on Science and Technology (PCAST) AGENCY: Office of Science, Department of... Council of Advisors on Science and Technology (PCAST) is an advisory group of the nation's leading scientists and engineers, appointed by the President to augment the science and technology advice...

  15. 77 FR 74837 - President's Council of Advisors on Science and Technology (PCAST)

    Science.gov (United States)

    2012-12-18

    ... President's Council of Advisors on Science and Technology (PCAST) AGENCY: Office of Science, Department of... President's Council of Advisors on Science and Technology (PCAST) is an advisory group of the nation's leading scientists and engineers, appointed by the President to augment the science and technology...

  16. 78 FR 68040 - President's Council of Advisors on Science and Technology Meeting

    Science.gov (United States)

    2013-11-13

    ... President's Council of Advisors on Science and Technology Meeting AGENCY: Department of Energy. ACTION... partially-closed meeting of the President's Council of Advisors on Science and Technology (PCAST), and... President to augment the science and technology advice available to him from inside the White House,...

  17. 78 FR 12302 - President's Council of Advisors on Science and Technology (PCAST)

    Science.gov (United States)

    2013-02-22

    ... President's Council of Advisors on Science and Technology (PCAST) AGENCY: Office of Science, Department of... President's Council of Advisors on Science and Technology (PCAST) is an advisory group of the nation's leading scientists and engineers, appointed by the President to augment the science and technology...

  18. 77 FR 29621 - President's Board of Advisors on Historically Black Colleges and Universities

    Science.gov (United States)

    2012-05-18

    ... education communities in a national dialogue regarding new HBCU programs and initiatives; (iii) improving...: 2012-12158] DEPARTMENT OF EDUCATION President's Board of Advisors on Historically Black Colleges and Universities AGENCY: U.S. Department of Education, President's Board of Advisors on Historically Black...

  19. Working with Youth on LGBT Issues: Why Gay-Straight Alliance Advisors Become Involved

    Science.gov (United States)

    Valenti, Maria; Campbell, Rebecca

    2009-01-01

    This phenomenological qualitative study explores motivation for citizen participation in a local context by exploring the experiences of Gay-Straight Alliance (GSA) club advisors from public high schools. Fourteen advisors from one midwestern state were randomly recruited for participation. Inductive and deductive qualitative analyses elucidated…

  20. GSA Advisors' Self-Efficacy Related to LGBT Youth of Color and Transgender Youth

    Science.gov (United States)

    Poteat, V. Paul; Scheer, Jillian R.

    2016-01-01

    Gay-Straight Alliances (GSAs) serve lesbian, gay, bisexual, transgender (LGBT) and heterosexual youth from diverse backgrounds. Although some attention has been given to youth members in general, little attention has been given to adult advisors. Among 47 GSA advisors from 33 high schools (39 cisgender female, 8 cisgender male), the authors…

  1. Advisor Influence Strategies: 10 Cross-Cultural Scenarios for Self-Assessment and Reflection

    Science.gov (United States)

    2010-10-01

    told them to quiet down. The advisor then told them it doesn’t matter who gives the instructions and instructions do not have to come from a General...action because the advisor is likely to be more effective if he engages in ego -stroking behavior with a person of such high rank. In Option C

  2. Comparison of the students’ satisfaction about the performance of academic advisors before and after the advisor project in Shahrekord University of Medical Sciences

    Directory of Open Access Journals (Sweden)

    MASOUMEH DELARAM

    2014-01-01

    Full Text Available Introduction: Inappropriate advice interferes with the students’ achievement of educational and professional goals and they may fail to use proper resources for their educational needs. The present study was carried out to compare the students’ satisfaction about the performance of academic advisors before and after the advisor project in Shahrekord University of Medical Sciences. Methods: This longitudinal study was carried out using census report on 244 students in different courses at Shahrekord University of Medical Sciences in two stages at the first semester of 2010-2011 and first semester of 2011-2012. To collect the data, we used a self-designed questionnaire including individual and educational information and 10 multiple-choice questions with Likert scale to assess the students’ satisfaction about the advisors’ performance. Data were analyzed in SPSS 14 using paired t-test, qui-square test. P<0.05 was considered significant. Results: Of the ten items of satisfaction, there was only a significant difference in “accessibility to an advisor before and after the advisor project in students of nursing and midwifery school” (p=0.010, and the difference was not significant in other items in these students. No significant difference was found in ten items of satisfaction in students at other schools before and after the advisor project (p=0.010. Conclusion: It seems that the implementation of advisor project could not provide a satisfactory position for students. Adequate supervision of university officials on proper implementation of the advisor project, supporting faculty advisors and strengthening their position can help to improve the process.

  3. Stability of the Plasmodium falciparum AMA1-RON2 Complex Is Governed by the Domain II (DII Loop.

    Directory of Open Access Journals (Sweden)

    Roberto F Delgadillo

    Full Text Available Plasmodium falciparum is an obligate intracellular protozoan parasite that employs a highly sophisticated mechanism to access the protective environment of the host cells. Key to this mechanism is the formation of an electron dense ring at the parasite-host cell interface called the Moving Junction (MJ through which the parasite invades. The MJ incorporates two key parasite components: the surface protein Apical Membrane Antigen 1 (AMA1 and its receptor, the Rhoptry Neck Protein (RON complex, the latter one being targeted to the host cell membrane during invasion. Crystal structures of AMA1 have shown that a partially mobile loop, termed the DII loop, forms part of a deep groove in domain I and overlaps with the RON2 binding site. To investigate the mechanism by which the DII loop influences RON2 binding, we measured the kinetics of association and dissociation and binding equilibria of a PfRON2sp1 peptide with both PfAMA1 and an engineered form of PfAMA1 where the flexible region of the DII loop was replaced by a short Gly-Ser linker (ΔDII-PfAMA1. The reactions were tracked by fluorescence anisotropy as a function of temperature and concentration and globally fitted to acquire the rate constants and corresponding thermodynamic profiles. Our results indicate that both PfAMA1 constructs bound to the PfRON2sp1 peptide with the formation of one intermediate in a sequential reversible reaction: A↔B↔C. Consistent with Isothermal Titration Calorimetry measurements, final complex formation was enthalpically driven and slightly entropically unfavorable. Importantly, our experimental data shows that the DII loop lengthened the complex half-life time by 18-fold (900 s and 48 s at 25°C for Pf and ΔDII-Pf complex, respectively. The longer half-life of the Pf complex appeared to be driven by a slower dissociation process. These data highlight a new influential role for the DII loop in kinetically locking the functional binary complex to enable host

  4. Phase 1 Trial of AMA1-C1/Alhydrogel plus CPG 7909: An Asexual Blood-Stage Vaccine for Plasmodium falciparum Malaria

    OpenAIRE

    Mullen, Gregory E. D.; Ellis, Ruth D; Kazutoyo Miura; Elissa Malkin; Caroline Nolan; Mhorag Hay; Michael P Fay; Allan Saul; Daming Zhu; Kelly Rausch; Samuel Moretz; Hong Zhou; Long, Carole A.; Miller, Louis H.; John Treanor

    2008-01-01

    BACKGROUND: Apical Membrane Antigen 1 (AMA1), a polymorphic merozoite surface protein, is a leading blood-stage malaria vaccine candidate. This is the first reported use in humans of an investigational vaccine, AMA1-C1/Alhydrogel, with the novel adjuvant CPG 7909. METHODS: A phase 1 trial was conducted at the University of Rochester with 75 malaria-naive volunteers to assess the safety and immunogenicity of the AMA1-C1/Alhydrogel+CPG 7909 malaria vaccine. Participants were sequentially enroll...

  5. Evaluating Community Health Advisor (CHA) Core Competencies: The CHA Core Competency Retrospective Pretest/Posttest (CCCRP).

    Science.gov (United States)

    Story, Lachel; To, Yen M

    2016-05-01

    Health care and academic systems are increasingly collaborating with community health advisors (CHAs) to provide culturally relevant health interventions that promote sustained community transformation. Little attention has been placed on CHA training evaluation, including core competency attainment. This study identified common CHA core competencies, generated a theoretically based measure of those competencies, and explored psychometric properties of that measure. A concept synthesis revealed five CHA core competencies (leadership, translation, guidance, advocacy, and caring). The CHA Core Competency Retrospective Pretest/Posttest (CCCRP) resulted from that synthesis, which was administered using multiple approaches to individuals who previously received CHA training (N= 142). Exploratory factor analyses revealed a two-factor structure underlying the posttraining data, and Cronbach's alpha indicated high internal consistency. This study suggested some CHA core competencies might be more interrelated than previously thought, and two major competencies exist rather than five and supported the CCCRP's use to evaluate core competency attainment resulting from training.

  6. Research Traffic Management Advisor (rTMA) Up-level Final Report

    Science.gov (United States)

    Capps, Richard A.

    2013-01-01

    The FAA Time Based Flow Management (TBFM) Program provides for operational use and continued development of the Traffic Management Advisor (TMA) technology that NASA demonstrated in 1996. Although NASA's Center-TRACON Automation System (CTAS) software baseline includes advanced versions of TMA, some research activities are better served by a version of TMA that more closely matches the FAA's TBFM software. Beginning in 2009, NASA created Research TMA (rTMA) to enable researchers to work with FAA TBFM software in a research environment. The original rTMA was derived from TBFM v3.10 and later up-leveled to TBFM v3.12. This report documents the most recent up-level effort in which rTMA was re-derived from TBFM v4.00.07.

  7. Career Preparation: An Often Omitted Element of the Advisor-Graduate Student Relationship

    Science.gov (United States)

    McManus, D. A.

    2001-05-01

    Most graduate research advisors care about the education of their graduate students. However, they often define "graduate education" so narrowly that it consists only of solving a research problem. This narrow definition is consistent with their principal goal as geoscientists, to understand the Earth better, and with the reward system typical of research universities, with its emphasis on research. As a result, most advisors usually well prepare students to be researchers in research universities. Research, however, is only part of a faculty member's duties. Commonly omitted is mentoring in the teaching and service duties of a faculty member. Students interested in teaching, in positions in other academic institutions, or in careers outside of academia may be perceived as questioning the advisors' career values and may not be encouraged in these interests. Graduate students should take an active role in their education. In addition to seeking information on career preparation from the campus career center and teaching center and from books, newsmagazines, newspapers, and seminars, students should also seek mentors who have demonstrated an interest in what the student is interested in: teaching and service, as well as research, or in careers outside academia. These mentors may be the students' committee members, other faculty members, or other professional geoscientists. With a broad base of information and some personal decisions, students will have a rationale for exploring careers. The questions students ask can now be more specific: How do they gain the requisite breadth in knowledge and the beneficial skills, beyond the depth of the research experience, and how do they gain opportunities to practice these skills? In short, how can they experience, and preferably practice, what professional geoscientists do in particular careers? If necessary, graduate students can work together to answer these questions by inviting experts to offer workshops in the department

  8. 犬新孢子虫NcAMA1基因重组腺病毒穿梭质粒的构建及其真核表达%Construction and eukaryotic expression of the recombinant adenovirus shuttle plasmid with NcAMA1 gene of Neospora caninum

    Institute of Scientific and Technical Information of China (English)

    郭焕平; 贾立军; 于龙政; 薛书江; 高洋; 李男礼; 张守发

    2014-01-01

    为构建犬新孢子虫NcAMA1基因重组腺病毒穿梭质粒,并在真核细胞中表达,以重组质粒pVAX1-NcAMA1为模板,PCR扩增了NcAMA1基因,以此构建了pMD18T-NcAMA1重组克隆质粒;对该重组克隆质粒进行双酶切鉴定后,将其亚克隆至腺病毒穿梭载体pCR259中.应用脂质体介导转染法将经PCR鉴定和酶切鉴定正确的pCR259-NcAMA1重组穿梭质粒转染293细胞,应用IFAT和Western-blot技术检测了AMA1基因在293细胞中的表达情况.结果显示,扩增的NcAMA1基因长度为1 695 bp,构建的重组腺病毒穿梭质粒pCR259-NcAMA1能在293细胞中获得瞬时表达,表达蛋白的分子质量约为68 ku.

  9. 犬新孢子虫AMA1基因重组猫疱疹病毒1型转移载体的构建及真核表达%Construction and eukaryotic expression of recombinant feline herpesvirus type 1 transfer vector with Neospora caninum AMA1 gene

    Institute of Scientific and Technical Information of China (English)

    郭焕平; 张守发; 高洋; 贾洪林; 贾立军

    2014-01-01

    为构建犬新孢子虫AMA1基因重组猫疱疹病毒1型(FHVl)转移质粒pBS-TK-NcAMA1,并在真核细胞中表达,以重组质粒pVAX1-NcAMA1为模板,扩增犬新孢子虫AMA1基因,并将其亚克隆至重组质粒pBS-TK.通过转染试剂PEI将pBS-TK-NcAMA1转移载体转染至293T细胞,以制备的小鼠抗犬新孢子虫AMA1蛋白的特异性抗体为一抗,应用间接免疫荧光试验和Western-blot对基因的表达情况进行鉴定.结果显示,构建的病毒转移载体pBS-TK-NcAMA1可以在293T细胞内获得表达,表达蛋白的分子质量为68 ku.这一研究成果为犬新孢子虫AMA1基因的重组猫疱疹病毒1型载体疫苗的研制奠定了基础.

  10. Advisor Influence Strategies: 10 Cross-Cultural Scenarios for Discussion and Self-Assessment (Instructor’s Manual)

    Science.gov (United States)

    2010-09-01

    quiet down. The advisor then told them it doesn’t matter who gives the instructions and instructions do not have to come from a General in order for...the advisor is likely to be more effective if he engages in ego -stroking behavior with a person of such high rank. In Option C, the advisor is

  11. Teaching with Real-time Earthquake Data in jAmaSeis

    Science.gov (United States)

    Bravo, T. K.; Coleman, B.; Taber, J.

    2011-12-01

    Earthquakes can capture the attention of students and inspire them to explore the Earth. The Incorporated Research Institutions in Seismology (IRIS) and Moravian College are collaborating to develop cross-platform software (jAmaSeis) that enables students to access real-time earthquake waveform data. Users can record their own data from several different types of educational seismometers, and they can obtain data in real-time from other jAmaseis users nationwide. Additionally, the ability to stream data from the IRIS Data Management Center (DMC) is under development. Once real-time data is obtained, users of jAmaseis can study seismological concepts in the classroom. The user interface of the software is carefully designed to lead students through the steps to interrogate seismic data following a large earthquake. Users can process data to determine characteristics of seismograms such as time of occurrence, distance from the epicenter to the station, magnitude, and location (via triangulation). Along the way, the software provides graphical clues to assist student interpretations. In addition to the inherent pedagogical features of the software, IRIS provides pre-packaged data and instructional activities to help students learn the analysis steps. After using these activities, students can apply their skills to interpret seismic waves from their own real-time data.

  12. Scientific writing: strategies and tools for students and advisors.

    Science.gov (United States)

    Singh, Vikash; Mayer, Philipp

    2014-01-01

    Scientific writing is a demanding task and many students need more time than expected to finish their research articles. To speed up the process, we highlight some tools, strategies as well as writing guides. We recommend starting early in the research process with writing and to prepare research articles, not after but in parallel to the lab or field work. We suggest considering scientific writing as a team enterprise, which needs proper organization and regular feedback. In addition, it is helpful to select potential target journals early and to consider not only scope and reputation, but also decision times and rejection rates. Before submission, instructions to authors and writing guides should be considered, and drafts should be extensively revised. Later in the process editor's and reviewer's comments should be followed. Our tips and tools help students and advisors to structure the writing and publishing process, thereby stimulating them to develop their own strategies to success.

  13. Molecular characterization of lysR-lysXE, gcdR-gcdHG and amaR-amaAB operons for lysine export and catabolism: a comprehensive lysine catabolic network in Pseudomonas aeruginosa PAO1.

    Science.gov (United States)

    Madhuri Indurthi, Sai; Chou, Han-Ting; Lu, Chung-Dar

    2016-05-01

    Among multiple interconnected pathways for l-Lysine catabolism in pseudomonads, it has been reported that Pseudomonas aeruginosa PAO1 employs the decarboxylase and the transaminase pathways. However, up until now, knowledge of several genes involved in operation and regulation of these pathways was still missing. Transcriptome analyses coupled with promoter activity measurements and growth phenotype analyses led us to identify new members in l-Lys and d-Lys catabolism and regulation, including gcdR-gcdHG for glutarate utilization, dpkA, amaR-amaAB and PA2035 for d-Lys catabolism, lysR-lysXE for putative l-Lys efflux and lysP for putative l-Lys uptake. The gcdHG operon encodes an acyl-CoA transferase (gcdG) and glutaryl-CoA dehydrogenase (gcdH) and is under the control of the transcriptional activator GcdR. Growth on l-Lys was enhanced in the mutants of lysX and lysE, supporting the operation of l-Lys efflux. The transcriptional activator LysR is responsible for l-Lys specific induction of lysXE and the PA4181-82 operon of unknown function. The putative operator sites of GcdR and LysR were deduced from serial deletions and comparative genomic sequence analyses, and the formation of nucleoprotein complexes was demonstrated with purified His-tagged GcdR and LysR. The amaAB operon encodes two enzymes to convert pipecolate to 2-aminoadipate. Induction of the amaAB operon by l-Lys, d-Lys and pipecolate requires a functional AmaR, supporting convergence of Lys catabolic pathways to pipecolate. Growth on pipecolate was retarded in the gcdG and gcdH mutants, suggesting the importance of glutarate in pipecolate and 2-aminoadipate utilization. Furthermore, this study indicated links in the control of interconnected networks of lysine and arginine catabolism in P. aeruginosa.

  14. Enhancement of functional antibody responses to AMA1-C1/Alhydrogel, a Plasmodium falciparum malaria vaccine, with CpG oligodeoxynucleotide.

    Science.gov (United States)

    Mullen, Gregory E D; Giersing, Birgitte K; Ajose-Popoola, Olubunmi; Davis, Heather L; Kothe, Cheryl; Zhou, Hong; Aebig, Joan; Dobrescu, Gelu; Saul, Allan; Long, Carole A

    2006-03-24

    Apical membrane antigen 1 (AMA1) has been shown to be a promising malaria vaccine candidate. The multiallelic AMA1-C1 vaccine currently in Phase 1 trials in the US and Mali contains an equal mixture of the ectodomain portion of recombinant AMA1 from the FVO and 3D7 clones of Plasmodium falciparum, formulated on Alhydrogel. It is hoped that inclusion of a human-optimized CpG oligodeoxynucleotide (ODN) (CPG 7909) with our existing AMA1-C1/Alhydrogel vaccine will lead to a higher concentration of functional AMA1-C1 antibodies. Preclinical studies were performed in mice, rats and guinea pigs to assess the safety, immunogenicity and functionality of the immune response to AMA1-C1 with Alhydrogel + CPG 7909 compared to antigen with Alhydrogel alone. Day 42 mean anti-AMA1 ELISA titer values derived from individual animals were compared between Alhydrogel and Alhydrogel + CPG 7909 groups at each antigen dose for each species. Sera from Alhydrogel + CPG 7909 groups displayed significantly higher antibody titers (P CPG 7909 gave a mixed Th1/Th2 type response. When tested for functional activity by in vitro inhibition of parasite invasion, IgG isolated from serum pools of AMA1-C1/Alhydrogel + CPG 7909 animals was more effective against both FVO and 3D7 parasites than an equal concentration of IgG from animals receiving vaccines adjuvanted with Alhydrogel alone. These promising preclinical results have recently led to the start of a Phase 1 trial in the US.

  15. Adenovirus 5-vectored P. falciparum vaccine expressing CSP and AMA1. Part A: safety and immunogenicity in seronegative adults.

    Directory of Open Access Journals (Sweden)

    Martha Sedegah

    Full Text Available BACKGROUND: Models of immunity to malaria indicate the importance of CD8+ T cell responses for targeting intrahepatic stages and antibodies for targeting sporozoite and blood stages. We designed a multistage adenovirus 5 (Ad5-vectored Plasmodium falciparum malaria vaccine, aiming to induce both types of responses in humans, that was tested for safety and immunogenicity in a Phase 1 dose escalation trial in Ad5-seronegative volunteers. METHODOLOGY/PRINCIPAL FINDINGS: The NMRC-M3V-Ad-PfCA vaccine combines two adenovectors encoding circumsporozoite protein (CSP and apical membrane antigen-1 (AMA1. Group 1 (n = 6 healthy volunteers received one intramuscular injection of 2×10∧10 particle units (1×10∧10 each construct and Group 2 (n = 6 a five-fold higher dose. Transient, mild to moderate adverse events were more pronounced with the higher dose. ELISpot responses to CSP and AMA1 peaked at 1 month, were higher in the low dose (geomean CSP = 422, AMA1 = 862 spot forming cells/million than in the high dose (CSP = 154, p = 0.049, AMA1 = 423, p = 0.045 group and were still positive at 12 months in a number of volunteers. ELISpot depletion assays identified dependence on CD4+ or on both CD4+ and CD8+ T cells, with few responses dependent only on CD8+ T cells. Intracellular cytokine staining detected stronger CD8+ than CD4+ T cell IFN-γ responses (CSP p = 0.0001, AMA1 p = 0.003, but similar frequencies of multifunctional CD4+ and CD8+ T cells secreting two or more of IFN-γ, TNF-α or IL-2. Median fluorescence intensities were 7-10 fold higher in triple than single secreting cells. Antibody responses were low but trended higher in the high dose group and did not inhibit growth of cultured P. falciparum blood stage parasites. SIGNIFICANCE: As found in other trials, adenovectored vaccines appeared safe and well-tolerated at doses up to 1×10∧11 particle units. This is the first demonstration in humans of a

  16. [Glimpsing undergraduate research from the view of the advisors of Nursing scholarships].

    Science.gov (United States)

    Erdmann, Alacoque Lorenzini; Leite, Joséte Luzia; Nascimento, Keyla Cristiane do; Lanzoni, Gabriela Marcellino de Melo

    2011-01-01

    This research aimed at understanding the meaning of undergraduate research for supervisors of Nursing scholarship students in a university in the South of Brazil. The methodological reference used was the Grounded Theory, by the means of interviews with seven undergraduate research scholarship advisors forming two sample groups. The phenomenon "glimpsing undergraduate research activities of research groups coordinated by nursing advisors, the basis of competency formation in research of the scholarships" emerged form the interrelation of six categories. To be a advisor and researcher of human resources in research form undergraduation requires pedagogical, instrumental, and managerial competencies associated to research policies of nursing and health.

  17. Servqual Method: Analisis Kualitas Pelayanan Beauty Advisor Sari Ayu Martha Tilaar

    Directory of Open Access Journals (Sweden)

    Ami Widyastuti

    2012-12-01

    Full Text Available Penelitian ini bertujuan untuk menganalisa kualitas pelayanan beauty advisor Sari Ayu Martha Tilaar guna meningkatkan kualitas pelayanan pada konsumen. Pengambilan data menggunakan skala kualitas pelayanan yang disusun berdasarkan metode Servqual dari (Parasuraman, dkk., 1988 pada 72 orang konsumen Sari Ayu Martha Tilaar. Sampel diambil dengan menggunakan teknik insidental random sampling. Analisis data menggunakan pengukuran gap 5 dari metode Servqual. Hasil penelitian menemukan ada kesenjangan pelayanan (service gap antara persepsi dan harapan konsumen sebesar -81.09 dimana nilai minus disini berarti, kinerja kerja beauty advisor Sari Ayu Martha Tilaar berada pada kategori rendah. Kesimpulannya, beauty advisor sebagai garda lini depan dalam pemasaran belum bekerja secara optimal.

  18. From Surviving to Advising: A Novel Course Pairing Mental Health and Addictions Service Users as Advisors to Senior Psychiatry Residents.

    Science.gov (United States)

    Agrawal, Sacha; Capponi, Pat; López, Jenna; Kidd, Sean; Ringsted, Charlotte; Wiljer, David; Soklaridis, Sophie

    2016-06-01

    The authors describe a novel course that pairs service users as advisors to senior psychiatry residents with the goals of improving the residents' understanding of recovery, reducing negative stereotypes about people in recovery, and empowering the service users who participated. Service users who had experience working as peer support workers and/or system advocates were selected for a broad and deep understanding of recovery and an ability to engage learners in constructive dialogue. They met monthly with resident advisees over a period of 6 months. They were supported with monthly group supervision meetings and were paid an honorarium. Quantitative evaluations and qualitative feedback from the first two cohorts of the course, comprising 34 pairs, are reported here. The first cohort of residents responded with a wide range of global ratings and reactions. In response to their suggestions, changes were made to the structure of the course to create opportunities for small group learning and reflective writing and to protect time for residents to participate. The second cohort of residents and both cohorts of service users gave acceptably high global ratings. Residents in the second cohort described gaining a number of benefits from the course, including an enhanced understanding of the lived experience of recovery and a greater sense of shared humanity with service users. Advisors described an appreciation for being part of something that has the potential for changing the practice of psychiatry and enhancing the lives of their peers. Positioning service users as advisors to psychiatry residents holds promise as a powerful way of reducing distance between future psychiatrists and service users and facilitating system reform toward person-centered recovery-oriented care.

  19. The App Squad: SLJ's Advisors Weigh in on Kids' Book Apps

    Science.gov (United States)

    Ishizuka, Kathy

    2011-01-01

    In this article, "School Library Journal's" ("SLJ") advisors talk about book apps for kids. They discuss what they like, what one should look for in discerning the best for kids and teens, and where this all might be headed.

  20. Undergraduate Students' Perceptions of the Communication Behaviors of Their Advisors and Perceptions of Relational Satisfaction

    National Research Council Canada - National Science Library

    Narissra Punyanunt-Carter; Stacy Carter

    2015-01-01

      This study examined the specific interpersonal communication styles and behaviors of advisors and the expectations they have on their advisee's level of satisfaction, as well as what characteristics...

  1. 76 FR 7550 - President's Board of Advisors on Historically Black Colleges and Universities

    Science.gov (United States)

    2011-02-10

    ..., business, government, military, homeland- security, and education communities in a national dialogue... From the Federal Register Online via the Government Publishing Office DEARTMENT OF EDUCATION... Education, President's Board of Advisors on Historically Black Colleges and Universities (Board)....

  2. 75 FR 53279 - President's Board of Advisors on Historically Black Colleges and Universities

    Science.gov (United States)

    2010-08-31

    ... education communities in a national dialogue regarding new HBCU programs and initiatives; (iii) improving... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF EDUCATION... Education, President's Board of Advisors on Historically Black Colleges and Universities (Board)....

  3. 78 FR 11865 - President's Board of Advisors on Historically Black Colleges and Universities

    Science.gov (United States)

    2013-02-20

    ... education communities in a national dialogue regarding new HBCU programs and initiatives; (iii) improving... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF EDUCATION... Education, President's Board of Advisors on Historically Black Colleges and Universities (Board)....

  4. 78 FR 31910 - President's Board of Advisors on Historically Black Colleges and Universities

    Science.gov (United States)

    2013-05-28

    ..., business, government, military, homeland- security, and education communities in a national dialogue... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF EDUCATION... Education, President's Board of Advisors on Historically Black Colleges and Universities (Board)....

  5. The App Squad: SLJ's Advisors Weigh in on Kids' Book Apps

    Science.gov (United States)

    Ishizuka, Kathy

    2011-01-01

    In this article, "School Library Journal's" ("SLJ") advisors talk about book apps for kids. They discuss what they like, what one should look for in discerning the best for kids and teens, and where this all might be headed.

  6. What Are Faculty Advisors To Do When Their Own Career Path Does Not Satisfy Their Students?

    Science.gov (United States)

    McManus, D. A.

    2001-12-01

    As graduate students seek advice on broad career options, many faculty advisors do not know what to do. It is easy for them to do nothing. They may do nothing because they assume that their own students are interested only in an academic research career like theirs. The mistake here can be that the advisors' verbal and non-verbal communication deters students from mentioning their interests in the first place or pursuing those interests, if mentioned. Or advisors may do nothing by assuming that it is not their responsibility to advise students about career options other than being an academic researcher. The advisors' lack of knowledge about other careers may lead them to avoid the issue. The mistake here is obvious. So what are advisors to do? They can encourage students to think of their graduate study as part of their career preparation, not just a task to obtain a research degree. Creating a risk-free environment for career discussion will enable faculty advisors to learn each student's career priorities and validate exploration of broad career options. Advisors should not feel inadequate by being unable to advise about everything. No one expects them to. They can encourage their students to meet together, on their own if necessary, to discuss common career concerns, even to invite speakers, including alums, to talk about different careers and the preparation required. They can encourage their students to seek additional mentors, people more knowledgeable about careers of interest to the students. They can encourage students to take courses for career preparation, particularly courses outside of science, even though these courses "take them away from their research." And advisors should not hold students at fault if they change their minds about career paths. More information often changes minds. These are a few of the many things that advisors can do. It is essential that faculty advisors not resent students' decisions to follow a career path different from

  7. Business Model Configuration in Financial Advisor Sector. The case of polish SME.

    OpenAIRE

    Adome, Teja

    2016-01-01

    This study examined a proper business model for financial advisor sector in polish SME. It analyzed the research question “How to build a proper business model for SME, operating in Polish Financial Advisor Sector?” and identified the importance of 10 business model elements for successful business management. The theoretical business model configuration was explored by qualitative research method with supplementary of a shorter descriptive survey from ends users. Both methods showed the ...

  8. The Foreign Area Officer Program. Volume I. The Role of the Military Advisor

    Science.gov (United States)

    1973-05-01

    attended the MAPA or MAO C&SC, and are not MAOP members. Some of these positions are advisory posi- tions. For purposes of this report, we did not...determine whether there is a comparable problem at the MAAG end--i.e. , requisitioning MAPA or MAO C&SC graduates and not getting them—or to what...U. S. Army training in advisor functions and roles is incorporated in the Military Assistance Programmer/Advisor ( MAPA ) and Military Assistance

  9. ama1 genes of sympatric Plasmodium vivax and P. falciparum from Venezuela differ significantly in genetic diversity and recombination frequency.

    Directory of Open Access Journals (Sweden)

    Rosalynn L Ord

    Full Text Available BACKGROUND: We present the first population genetic analysis of homologous loci from two sympatric human malaria parasite populations sharing the same human hosts, using full-length sequences of ama1 genes from Plasmodium vivax and P. falciparum collected in the Venezuelan Amazon. METHODOLOGY/PRINCIPAL FINDINGS: Significant differences between the two species were found in genetic diversity at the ama1 locus, with 18 distinct haplotypes identified among the 73 Pvama1 sequences obtained, compared to 6 unique haplotypes from 30 Pfama1 sequences, giving overall diversity estimates of h = 0.9091, and h = 0.538 respectively. Levels of recombination were also found to differ between the species, with P. falciparum exhibiting very little recombination across the 1.77 kb sequence. In contrast, analysis of patterns of nucleotide substitutions provided evidence that polymorphisms in the ama1 gene of both species are maintained by balancing selection, particularly in domain I. The two distinct population structures observed are unlikely to result from different selective forces acting upon the two species, which share both human and mosquito hosts in this setting. Rather, the highly structured P. falciparum population appears to be the result of a population bottleneck, while the much less structured P. vivax population is likely to be derived from an ancient pool of diversity, as reflected in a larger estimate of effective population size for this species. Greatly reduced mosquito transmission in 1997, due to low rainfall prior to the second survey, was associated with far fewer P. falciparum infections, but an increase in P. vivax infections, probably due to hypnozoite activation. CONCLUSIONS/SIGNIFICANCE: The relevance of these findings to putative competitive interactions between these two important human pathogen species is discussed. These results highlight the need for future control interventions to employ strategies targeting each of the parasite

  10. Safety and immunogenicity of an AMA-1 malaria vaccine in Malian adults: results of a phase 1 randomized controlled trial.

    Directory of Open Access Journals (Sweden)

    Mahamadou A Thera

    Full Text Available BACKGROUND: The objective was to evaluate the safety, reactogenicity and immunogenicity of the AMA-1-based blood-stage malaria vaccine FMP2.1/AS02A in adults exposed to seasonal malaria. METHODOLOGY/PRINCIPAL FINDINGS: A phase 1 double blind randomized controlled dose escalation trial was conducted in Bandiagara, Mali, West Africa, a rural town with intense seasonal transmission of Plasmodium falciparum malaria. The malaria vaccine FMP2.1/AS02A is a recombinant protein (FMP2.1 based on apical membrane antigen-1 (AMA-1 from the 3D7 clone of P. falciparum, adjuvanted with AS02A. The comparator vaccine was a cell-culture rabies virus vaccine (RabAvert. Sixty healthy, malaria-experienced adults aged 18-55 y were recruited into 2 cohorts and randomized to receive either a half dose or full dose of the malaria vaccine (FMP2.1 25 microg/AS02A 0.25 mL or FMP2.1 50 microg/AS02A 0.5 mL or rabies vaccine given in 3 doses at 0, 1 and 2 mo, and were followed for 1 y. Solicited symptoms were assessed for 7 d and unsolicited symptoms for 30 d after each vaccination. Serious adverse events were assessed throughout the study. Titers of anti-AMA-1 antibodies were measured by ELISA and P. falciparum growth inhibition assays were performed on sera collected at pre- and post-vaccination time points. Transient local pain and swelling were common and more frequent in both malaria vaccine dosage groups than in the comparator group. Anti-AMA-1 antibodies increased significantly in both malaria vaccine groups, peaking at nearly 5-fold and more than 6-fold higher than baseline in the half-dose and full-dose groups, respectively. CONCLUSION/SIGNIFICANCE: The FMP2.1/AS02A vaccine had a good safety profile, was well-tolerated, and was highly immunogenic in malaria-exposed adults. This malaria vaccine is being evaluated in Phase 1 and 2 trials in children at this site.

  11. Report 59 of the AMA Board of Trustees (A-96). Physician-assisted suicide. Reference Committee on Amendments to Constitution and Bylaws.

    Science.gov (United States)

    1996-08-01

    This Board of Trustees report calls for reaffirmation of the position of the American Medical Association (AMA) in opposition to physicians assisting their patients in committing suicide. The AMA maintains that the appropriate step for physicians is not to assist a patient in death but to provide compassion and palliative care. In providing end-of-life care, the option of allowing physicians to intentionally cause the death of patients is a line that should not be crossed. This position is based on the historical role of physicians as advocates for healing. The report discusses AMA activity to design and implement a comprehensive physician education plan on end-of-life care in response to the House of Delegates' action in adopting Board of Trustees Report 48-I-95, "Quality Care at the End of Life." This plan will further the AMA's commitment that patients should receive high quality care during every stage of life, including the end of life. The goal of this educational campaign is to advance the medical culture by making palliative treatment and care directions based on values-based advance care planning the standard of care for meeting the needs of patients at the end of life. The basis for this activity will be the acknowledgment that physicians, while unable to always provide a cure, should always be able to relieve suffering, address the psychological needs of patients at the end of life, add value to remaining life, and help patients die with dignity. The report presents information on state legislative activities and judicial actions relating to physician-assisted suicide. The report also presents a discussion on the ethical under-pinnings against physician participation in patients' suicides. This report recommends that: the AMA reaffirm current policies 140.952 and 140.966 (AMA Policy Compendium), in accordance with Council on Ethical and Judicial Affairs Opinion 2.211 (opposition to physician-assisted suicide); the AMA initiate an educational campaign to

  12. Detailed Physical Trough Model for NREL's Solar Advisor Model: Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, M. J.; Blair, N.; Dobos, A.

    2010-10-01

    Solar Advisor Model (SAM) is a free software package made available by the National Renewable Energy Laboratory (NREL), Sandia National Laboratory, and the US Department of Energy. SAM contains hourly system performance and economic models for concentrating solar power (CSP) systems, photovoltaic, solar hot-water, and generic fuel-use technologies. Versions of SAM prior to 2010 included only the parabolic trough model based on Excelergy. This model uses top-level empirical performance curves to characterize plant behavior, and thus is limited in predictive capability for new technologies or component configurations. To address this and other functionality challenges, a new trough model; derived from physical first principles was commissioned to supplement the Excelergy-based empirical model. This new 'physical model' approaches the task of characterizing the performance of the whole parabolic trough plant by replacing empirical curve-fit relationships with more detailed calculations where practical. The resulting model matches the annual performance of the SAM empirical model (which has been previously verified with plant data) while maintaining run-times compatible with parametric analysis, adding additional flexibility in modeled system configurations, and providing more detailed performance calculations in the solar field, power block, piping, and storage subsystems.

  13. Multilevel Precision-Based Rational Design of Chemical Inhibitors Targeting the Hydrophobic Cleft of Toxoplasma gondii Apical Membrane Antigen 1 (AMA1)

    Science.gov (United States)

    Muralikumar, Shalini; Mahalakshmi, B; Lily Therese, K; Madhavan, HN; Alameen, Mohamed; Thirumudi, Indhuja

    2016-01-01

    Toxoplasma gondii is an intracellular Apicomplexan parasite and a causative agent of toxoplasmosis in human. It causes encephalitis, uveitis, chorioretinitis, and congenital infection. T. gondii invades the host cell by forming a moving junction (MJ) complex. This complex formation is initiated by intermolecular interactions between the two secretory parasitic proteins—namely, apical membrane antigen 1 (AMA1) and rhoptry neck protein 2 (RON2) and is critically essential for the host invasion process. By this study, we propose two potential leads, NSC95522 and NSC179676 that can efficiently target the AMA1 hydrophobic cleft, which is a hotspot for targeting MJ complex formation. The proposed leads are the result of an exhaustive conformational search-based virtual screen with multilevel precision scoring of the docking affinities. These two compounds surpassed all the precision levels of docking and also the stringent post docking and cumulative molecular dynamics evaluations. Moreover, the backbone flexibility of hotspot residues in the hydrophobic cleft, which has been previously reported to be essential for accommodative binding of RON2 to AMA1, was also highly perturbed by these compounds. Furthermore, binding free energy calculations of these two compounds also revealed a significant affinity to AMA1. Machine learning approaches also predicted these two compounds to possess more relevant activities. Hence, these two leads, NSC95522 and NSC179676, may prove to be potential inhibitors targeting AMA1-RON2 complex formation towards combating toxoplasmosis. PMID:27445648

  14. Multilevel Precision-Based Rational Design of Chemical Inhibitors Targeting the Hydrophobic Cleft of Toxoplasma gondii Apical Membrane Antigen 1 (AMA1).

    Science.gov (United States)

    Vetrivel, Umashankar; Muralikumar, Shalini; Mahalakshmi, B; Lily Therese, K; Madhavan, H N; Alameen, Mohamed; Thirumudi, Indhuja

    2016-06-01

    Toxoplasma gondii is an intracellular Apicomplexan parasite and a causative agent of toxoplasmosis in human. It causes encephalitis, uveitis, chorioretinitis, and congenital infection. T. gondii invades the host cell by forming a moving junction (MJ) complex. This complex formation is initiated by intermolecular interactions between the two secretory parasitic proteins-namely, apical membrane antigen 1 (AMA1) and rhoptry neck protein 2 (RON2) and is critically essential for the host invasion process. By this study, we propose two potential leads, NSC95522 and NSC179676 that can efficiently target the AMA1 hydrophobic cleft, which is a hotspot for targeting MJ complex formation. The proposed leads are the result of an exhaustive conformational search-based virtual screen with multilevel precision scoring of the docking affinities. These two compounds surpassed all the precision levels of docking and also the stringent post docking and cumulative molecular dynamics evaluations. Moreover, the backbone flexibility of hotspot residues in the hydrophobic cleft, which has been previously reported to be essential for accommodative binding of RON2 to AMA1, was also highly perturbed by these compounds. Furthermore, binding free energy calculations of these two compounds also revealed a significant affinity to AMA1. Machine learning approaches also predicted these two compounds to possess more relevant activities. Hence, these two leads, NSC95522 and NSC179676, may prove to be potential inhibitors targeting AMA1-RON2 complex formation towards combating toxoplasmosis.

  15. [Humoral immune anti-Plasmodium falciparum AMA1 and MSP1 response in two ethnic groups living in sympatry in Mali].

    Science.gov (United States)

    Dolo, A; Coulibaly, M; Maïga, B; Daou, M; Arama, C; Troye-Blomberg, M; Doumbo, O

    2012-12-01

    Fulani of Mali are known for their lower susceptibility to Plasmodium falciparum malaria than their neighbours, the Dogon, despite similar transmission conditions. However, the mechanisms underlying these differences are poorly understood, particularly those concerning antigenspecific immune responses. The Apical Membrane Antigen 1 (AMA1) and the Merozoite Surface Antigen 1 (MSP1) are two malaria vaccine candidates, which play a pivotal role during the invasion of parasites into erythrocytes, and in the case of AMA1, of hepatocytes. Therefore, we analyzed the level of anti-AMA1 and anti-MSP1 antibodies (FVO and 3D7 alleles), by using ELISA (Enzyme Linked Immuno Sorbent Assay) to investigate whether there are differences between the two ethnic groups. Our results show that the splenic rate, the level of anti-AMA1 and anti-MSP1 were significantly higher in Fulani compared to Dogon; while the parasite rate was lower in Fulani group compared to Dogon. Our results suggest that the lower susceptibility of Fulani to malaria could be due to the higher specific humoral responses against AMA1 and MSP 1 in Fulani's ethnic group compared to Dogon.

  16. Building Partner Capacity: DOD Should Improve Its Reporting to Congress on Challenges to Expanding Ministry of Defense Advisors Program

    Science.gov (United States)

    2015-02-11

    Ministry of Defense Advisors ( MODA ) program more slowly than planned. It had 2 advisors in the field in Kosovo and Montenegro for most of fiscal year...approval process and with advisor recruitment and training. DOD has met most but not all legislative requirements for the MODA program. As required by...of each Global MODA deployment, which could help Congress assess the value of the program in relation to other capacity-building efforts (see figure

  17. Effects of quaternization on the morphological stability and antibacterial activity of electrospun poly(DMAEMA-co-AMA) nanofibers.

    Science.gov (United States)

    Xu, Jing-Wei; Wang, Yao; Yang, Yun-Feng; Ye, Xiang-Yu; Yao, Ke; Ji, Jian; Xu, Zhi-Kang

    2015-09-01

    Electrospun nanofibers with antibacterial activity are greatly promising for medical treatment and water purification. Herein we report antibacterial nanofibers electrospun from a series of poly(dimethylamino ethyl methacrylate-co-alkyl methacrylates) (poly(DMAEMA-co-AMA)) and to distinguish the effects of free and cross-linked cations derived from quanternization on the antibacterial activity. Poly(DMAEMA-co-AMA)s are simply synthesized by free radical polymerization from commercial monomers. DSC analysis indicates that they have Tg lower than room temperature and thus the electrospun nanofibers adhere to each other and evenly tend to form films, instead of keeping cylinderic shape. Benzyl chloride (BC) and p-xylylene dichloride (XDC) can quaternize DMAEMA units and to generate cations on the nanofiber surface. XPS analysis and colorimetric assay determine the quaternization degree and the surface accessible quaternary amines (N(+)), respectively. It is very promising that this quaternization endows the electrospun nanofibers with both stable morphology and antibacterial activity. The BC-quaternized fibers show better antibacterial behavior against Escherichia coli and Staphylococcus aureus than those of the XDC-quaternized/cross-linked ones, because cross-linking suppresses the chain mobility of cations. Our results confirm that antibacterial nanofibers can be facilely prepared and chain mobility of the formed cations is the necessary prerequisite for their antibacterial activity.

  18. Do Financial Advisors Live Up to Their Reputation: The Case of Major Assets Restructurings of Chinese Listed Companies

    Directory of Open Access Journals (Sweden)

    Wu Cen

    2017-01-01

    Full Text Available We investigate whether top-tier advisors provide superior services by examining the relationship between reputation (measured by whether it is a top-10 advisor ranked on deal value of financial advisors on the bidder side and stock market-based/accounting-based performance of bidders. Using Chinese listed companies with major assets reorganizations (MARs, M&As with large-scale target, we find top-tier advisors are associated with higher excess returns (CARs, implying that reputation generates a verification effect on investors. But we find no significant relationship between the advisor reputation and bidders’ accounting-based performance post-MARs. The findings indicate that although advisor reputation can attract M&A business and sends positive signal to the market, it does not lead to stronger financial performance in the long run. That is, the so-called top-tier financial advisors fail to live up to their reputation. We also find that payment premium is an intervening variable between advisor reputation and the long-term accounting-based performance of bidders, suggesting that top-tier advisors fail in their duties to help clients achieve greater share of synergy gains.

  19. "When We Learn Better, We Do Better": Describing Changes in Empowerment through Photovoice among Community Health Advisors in a Breast and Cervical Cancer Health Promotion Program in Mississippi and Alabama

    Science.gov (United States)

    Mayfield-Johnson, Susan; Rachal, John R.; Butler, James, III.

    2014-01-01

    As change agents in the community, community health advisors (CHAs) are a viable solution to bridge the gap between health service delivery systems and the community. With many CHAs members of the underserved and minority populations they serve, change and empowerment experienced by CHAs should be documented. This phenomenological study describes…

  20. Guide to good practices for the selection, training, and qualification of shift technical advisors

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1993-02-01

    The DOE Guide to Good Practices For the Selection, Training, and Qualification of Shift Technical Advisors can be used by any DOE nuclear facility that has implemented the shift technical advisor (STA) position. DOE Order 5480.20A, Personnel Selection, Qualification and Training Requirements for DOE Nuclear Facilities, states that only Category A reactors must have a shift technical advisor. However, many DOE nuclear facilities have implemented the shift technical advisor position to provide independent on-shift technical advice and counsel to the shift operating personnel to help determine cause and mitigation of facility accidents. Those DOE nuclear facilities that have implemented or are going to implement the shift technical advisor position will find this guide useful. This guide addresses areas that may be covered by other training programs. In these cases, it is unnecessary (and undesirable) to duplicate these areas in the STA training program as long as the specific skills and knowledge essential for STAs are addressed. The guide is based on the premise that the trainee has not completed any facility-specific training other than general employee training.

  1. Guide to good practices for the selection, training, and qualification of shift technical advisors

    Energy Technology Data Exchange (ETDEWEB)

    1993-02-01

    The DOE Guide to Good Practices For The Selection, Training, and Qualification of Shift Technical Advisors can be used by any DOE nuclear facility that has implemented the shift technical advisor position. DOE Order 5480-20, ``Personnel Selection, Qualification, Training, and Staffing Requirements at DOE Reactor and Non-Reactor Nuclear Facilities,`` states that only Category A reactors must use shift technical advisor position. However, many DOE nuclear facilities have implemented the shift technical advisor position to provide independent on-shift technical advice and counsel to the shift operating personnel to help determine cause and mitigation of facility accidents. Those DOE nuclear facilities that have implemented or are going to implement the shift technical advisor position will find this guide useful. This guide addresses areas that may be covered by other training programs. In these cases, it is unnecessary (and undesirable) to duplicate these areas in the STA training program as long as the specific skills and knowledge essential for STAs are addressed. The guide is presented based on the premise that the trainee has not completed any facility-specific training other than general employee training.

  2. Creating Rural Allied Health Leadership Structures Using District Advisors: An Action Research Project Using Program Logic.

    Science.gov (United States)

    Schmidt, David; Kurtz, Megan; Davidson, Stuart

    2017-01-01

    District advisors in five allied health disciplines were introduced in a local health district in rural Australia in 2013. These strategic leadership roles provide support to clinicians and managers. As there is little research exploring allied health leadership models from a strategic and operational perspective, the coordinated commencement of these roles provided opportunity to study the creation of this leadership structure. Four advisors participated in this action research study which used focus groups and program logic processes to explore the inputs, outputs, barriers, outcomes to date, and preferred future outcomes of the leadership model. A purpose-built questionnaire was sent to 134 allied health clinicians or managers with questionnaire responses used by advisors to visualise the leadership model. Advisors prioritised policy development, representing the profession outside the organisation, and supporting department managers, whilst clinicians prioritised communication and connection-building within the organisation. Outcomes of the leadership model included connection, coordination, and advocacy for clinicians. Future preferred outcomes included increased strategic and workforce planning. Barriers included limited time, a widespread workforce and limited resourcing. Instituting a leadership model improved communication, cohesion, and coordination within the organisation. Future increases in workforce planning and coordination are limited by advisor capacity and competing workloads.

  3. Viewpoints of students of Shahid Sadoughi University of Medical Sciences regarding their academic advisors

    Directory of Open Access Journals (Sweden)

    M.H Fallah Yakhdani

    2012-02-01

    Results: The majority of samples were from Nursing, Midwifery, and Public Health School and a few from Faculty of Medicine. The majority of students (41.8% agreed to have the same advisor from the first term to the last. Also the results showed that the functions of advisors were poor in the areas of constant supervision and monitoring of students’ educational status (35.8%, preparing the timetable for performing the personal or group counseling (41.8% and providing counseling sessions according to the timetable (42.3%. But their functions were fair in the areas of acceptable guidance of students in the educational problems (35.1%, and the advisor’s familiarity to educational regulations (43.9%. It is necessary to note that the advisor's ability in making the intimate relationship with students (37.1%, and the advisors’ motivation and tendency to guidance and counseling (30.1% were the two items evaluated excellent by students. Conclusion: It is necessary that advisors make the students familiar with educational regulations at the first semester of higher education. Also, the policies and regulations for advisors will clarify their activities and will help them to perform better.

  4. Inferring Advisor-Student Relationships from Publication Networks Based on Approximate MaxConfidence Measure

    Directory of Open Access Journals (Sweden)

    Yongjun Li

    2017-01-01

    Full Text Available A publication network contains abundant knowledge about advisor-student relationships. However, these relationship labels are not explicitly shown and need to be identified based on the hidden knowledge. The exploration of such relationships can benefit many interesting applications such as expert finding and research community analysis and has already drawn many scholars’ attention. In this paper, based on the common knowledge that a student usually coauthors his papers with his advisor, we propose an approximate MaxConfidence measure and present an advisor-student relationship identification algorithm based on the proposed measure. Based on the comparison of two authors’ publication list, we first employ the proposed measure to determine the time interval that a potential advising relationship lasts and then infer the likelihood of this potential advising relationship. Our algorithm suggests an advisor for each student based on the inference results. The experiment results show that our algorithm can infer advisor-student relationships efficiently and achieve a better accuracy than the time-constrained probabilistic factor graph (TPFG model without any supervised information. Also, we apply some reasonable restrictions on the dataset to reduce the search space significantly.

  5. Production, Quality Control, Stability and Pharmacotoxicity of a Malaria Vaccine Comprising Three Highly Similar PfAMA1 Protein Molecules to Overcome Antigenic Variation

    Science.gov (United States)

    Houard, Sophie; Havelange, Nicolas; Drossard, Jürgen; Mertens, Hubert; Croon, Alexander; Kastilan, Robin; Byrne, Richard; van der Werff, Nicole; van der Eijk, Marjolein; Thomas, Alan W.; Kocken, Clemens H. M.; Remarque, Edmond J.

    2016-01-01

    Plasmodium falciparum apical membrane antigen 1 (PfAMA1) is a leading asexual blood stage vaccine candidate for malaria. In preparation for clinical trials, three Diversity Covering (DiCo) PfAMA1 ectodomain proteins, designed to overcome the intrinsic polymorphism that is present in PfAMA1, were produced under Good Manufacturing Practice (GMP) in Pichia pastoris. Using identical methodology, the 3 strains were cultivated in 70-L scale fed-batch fermentations and PfAMA1-DiCos were purified by two chromatography steps, an ultrafiltration/diafiltration procedure and size exclusion chromatography, resulting in highly pure (>95%) PfAMA1-DiCo1, PfAMA1 DiCo2 and PfAMA1 DiCo3, with final yields of 1.8, 1.9 and 1.3 gram, respectively. N-terminal determinations showed that approximately 50% of each of the proteins lost 12 residues from their N-terminus, in accordance with SDS-PAGE (2 main bands) and MS-data. Under reducing conditions a site of limited proteolytic cleavage within a disulphide bonded region became evident. The three proteins quantitatively bound to the mAb 4G2 that recognizes a conformational epitope, suggesting proper folding of the proteins. The lyophilized Drug Product (1:1:1 mixture of PfAMA1-DiCo1, DiCo2, DiCo3) fulfilled all pre-set release criteria (appearance, dissolution rate, identity, purity, protein content, moisture content, sub-visible particles, immuno-potency (after reconstitution with adjuvant), abnormal toxicity, sterility and endotoxin), was stable in accelerated and real-time stability studies at -20°C for over 24 months. When formulated with adjuvants selected for clinical phase I evaluation, the Drug Product did not show adverse effect in a repeated-dose toxicity study in rabbits. The Drug Product has entered a phase Ia/Ib clinical trial. PMID:27695087

  6. Comparison performance of split plug-in hybrid electric vehicle and hybrid electric vehicle using ADVISOR

    Directory of Open Access Journals (Sweden)

    Mohd Rashid Muhammad Ikram

    2017-01-01

    Full Text Available Electric vehicle suffers from relatively short range and long charging times and consequently has not become an acceptable solution to the automotive consumer. The addition of an internal combustion engine to extend the range of the electric vehicle is one method of exploiting the high efficiency and lack of emissions of the electric vehicle while retaining the range and convenient refuelling times of a conventional gasoline powered vehicle. The term that describes this type of vehicle is a hybrid electric vehicle. Many configurations of hybrid electric vehicles have been designed and implemented, namely the series, parallel and power-split configurations. This paper discusses the comparison between Split Plug-in Hybrid Electric Vehicle(SPHEV and Hybrid Electric Vehicle(HEV. Modelling methods such as physics-based Resistive Companion Form technique and Bond Graph method are presented with powertrain component and system modelling examples. The modelling and simulation capability of existing tools such as ADvanced VehIcle SimulatOR (ADVISOR is demonstrated through application examples. Since power electronics is indispensable in hybrid vehicles, the issue of numerical oscillations in dynamic simulations involving power electronics is briefly addressed.

  7. Pain in amaXhosa women living with HIV/AIDS: a cross-sectional study of ambulant outpatients.

    Science.gov (United States)

    Parker, Romy; Jelsma, Jennifer; Stein, Dan J

    2017-04-13

    Pain is one of the most commonly reported symptoms in people living with HIV/AIDS, whether or not they are receiving anti-retroviral therapy. A recent systematic review identified a paucity of studies exploring pain in women in low and middle income countries. The prevalence and characteristics of pain in women living with HIV/AIDS may differ from that of men as many chronic pain conditions are more prevalent in women. The aims of this study were to establish pain prevalence, characteristics and management in amaXhosa women living with HIV/AIDS. In addition, we aimed to identify whether there were associations between pain in this population and the psychosocial factors of employment, education, self-efficacy, depression, post-traumatic stress disorder, health related quality of life and childhood trauma. A cross-sectional study of 229 women who had undergone HIV testing and were registered patients at a community health centre was conducted. Data were collected by interview with a demographic questionnaire, the Brief Pain Inventory-Xhosa, Childhood Trauma Questionnaire-Xhosa, Harvard Trauma Questionnaire-Xhosa for PTSD, Self-Efficacy for Managing Chronic Disease 6-Item Scale-Xhosa; the EQ-5D health related quality of life instrument, and the Beck Depression Inventory. 170 of the women had pain, a prevalence rate of 74.24% (95%CI 68.2 - 79.47%). The women reported significant pain with pain severity of 5.06 ± 1.57 and pain interference of 6.39 ± 1.96 out of 10. Only two women were receiving adequate pain management according to the pain management index. Participants reported a mean of 2.42 ± 1.21 different anatomical sites of pain. There were more unemployed participants in the group with pain and they had significantly fewer years of schooling. Those with pain had lower self-efficacy; health related quality of life and increased depression and PTSD symptom severity. This study highlights that pain is a common problem for amaXhosa women living with

  8. Immunological characteristics of primary biliary cirrhosis patients with AMA-M2 positive%AMA-M2阳性的原发性胆汁性肝硬化患者免疫学特点分析

    Institute of Scientific and Technical Information of China (English)

    王晗; 徐军; 刘佳; 郭静霞; 谢娜; 赵静; 陈霖; 宋永继; 杨丽华

    2013-01-01

    Objective To study the immunological characteristics of primary biliary cirrhosis patients with anti-mitochondrial antibody M2 subtype (AMA-M2) positive,for promoting early diagnosis and treatment of PBC.Methods Five kinds of autoantibodies including ANA,AMA,SMA,LKM and PCA in serum from 400 PBC patients with AMA-M2 positive were analyzed by indirect immunofluorescence assay and seven kinds of liver antigens including Sp100,PML,gp210,LKM-1,LC-1,SLA/LP and Ro-52 were tested by immunoblotting test.Biochemical indicators of ALP and γ-GT were assaied by automatic biochemical analyzer.Clinical hematology indicators of WBC,RBC,HGB,PLT and PT were assaied by automatic blood cell analyzer and automatic coagulation analyzer.Results The patients' main florescence patterns of ANA were nuclear envelope,multiple nuclear dots,centromere pattern and cytoplasm particles pattern,the positive rates were 70%,52%,43% and 3%.Fluorescent pattern combination models included multiple nuclear dots plus nuclear envelope,centromere pattern plus nuclear envelope,centromere pattern,multiple nuclear dots,cytoplasm particles pattern and only AMA positive pattern.The positive rate of those models were 42%,28%,15%,10%,3%,2%,and the titers were all beyond 1:320.The positive rate of SMA,PCA,LKM were all less than 5%.The main liver antigens of patiens were Ro-52,gp210,PML,Sp100 and the positive rate were 53 %,44%,43% and 24% respectively,and the titers were all beyond 1:320.The positive rate of other liver antigens including LKM-1,LC-1,SLA/LP were all less than 5%.Positive concordance rate of PML,Sp100 and Sp100 combined with PML to gp210 were 29%,11% and 7%.The detection of clinical hematology indicators show that in41% patients WBC and RBC levels reduced abnormally,in 53% patients and 38% patients the HGB and PLT levels reduced abnormally,while in 42% patients PT levels prolonged abnormally.The detection of biochemical indicators showed that in 96

  9. Autogordelgebruik van automobilisten in 1991 : een vergelijking van de resultaten van de Inkijkmethode (IMA) met de Afstandobservatiemethode (AMA) met betrekking tot het autogordelgebruik van bestuurders en passagiers op de voorbank van personenauto's.

    NARCIS (Netherlands)

    Verhoef, P.J.G

    1993-01-01

    The observation of safety belt use can be performed at a distance (AMA), or by looking inside the car (IMA). The aim of this study is to determine the reliability of the AMA method in comparison with the IMA method. Both methods were used in 1991 to observe both the drivers' and front seat passenger

  10. Employing virtual advisors in preventive care for underserved communities: results from the COMPASS study.

    Science.gov (United States)

    King, Abby C; Bickmore, Timothy W; Campero, Maria Ines; Pruitt, Leslie A; Yin, James Langxuan

    2013-01-01

    Electronically delivered health promotion programs that are aimed primarily at educated, health-literate individuals have proliferated, raising concerns that such trends could exacerbate health disparities in the United States and elsewhere. The efficacy of a culturally and linguistically adapted virtual advisor that provides tailored physical activity advice and support was tested in low-income older adults. Forty inactive adults (92.5% Latino) 55 years of age and older were randomized to a 4-month virtual advisor walking intervention or a waitlist control. Four-month increases in reported minutes of walking/week were greater in the virtual advisor arm (mean increase = 253.5 ± 248.7 minutes/week) relative to the control (mean increase = 26.8 ± 67.0 minutes/week; p = .0008). Walking increases in the virtual advisor arm were substantiated via objectively measured daily steps (slope analysis p = .002). All but one intervention participant continued some interaction with the virtual advisor in the 20-week poststudy period (mean number of poststudy sessions = 14.0 ± 20.5). The results indicate that a virtual advisor delivering culturally and linguistically adapted physical activity advice led to meaningful 4-month increases in walking relative to control among underserved older adults. This interactive technology, which requires minimal language and computer literacy, may help reduce health disparities by ensuring that all groups benefit from e-health opportunities.

  11. Bioinformatics analysis of AMA1 gene of Neospora caninum and construction of prokaryotic expression vector%犬新孢子虫AMA1基因的生物信息学分析及原核表达载体构建

    Institute of Scientific and Technical Information of China (English)

    李男礼; 贾立军; 郭焕平; 李积旭; 张守发

    2015-01-01

    为了解新孢子虫AMA1基因的生物信息学特性,并构建重组原核表达质粒pGEX-4T-1-NcAMA1.本试验对牛源犬新孢子虫吉林株AMA1基因进行分子克隆,利用生物信息学软件对该基因进行编码蛋白等电点、信号肽、跨膜区、糖基化位点及疏水性分析,并将该基因片段亚克隆至原核表达载体pGEX-4T-1,构建了重组表达质粒pGEX-4T-1-NcAMA1.结果显示,克隆的NcAMA1基因片段长1 695 bp,与GenBank(AB265823.1)上发表的基因序列同源性99.9%;NcAMA1基因编码蛋白等电点为5.43,在其N端及C端分别存在一个跨膜区,为不溶性蛋白,且NcAMA1蛋白抗原指数较高,有潜在疫苗研究价值.

  12. Profile of a leader: pioneer government advisor: Laura Holland, RN, RRC, CBE, LLD (1883 - 1956).

    Science.gov (United States)

    Paulson, E; Zilm, G; Warbinek, E

    2000-01-01

    Laura Holland, nurse and social worker, became one of Canada's first official "nurse advisors" to government when she was appointed Advisor to the B.C. Ministry of Health and Welfare from 1938 to 1945. Before that appointment, she had served, with distinction, as a Nursing Sister in World War I, brought innovative Red Cross and public health advances to northern Ontario, reformed Children's Aid services in Vancouver and B.C., and started a new department that combined nursing/social work in the field during the Great Depression of the 1930s. She was an extraordinary leader.

  13. The Role of the Graduate-Level Academic Advisor for Military and Student Veterans: An Ethnographic Study

    Science.gov (United States)

    Miller, Michelle A.

    2013-01-01

    The role of a graduate-level academic advisor is essential to all levels of higher education. With the introduction of the Post 9/11 GI Bill, there has been an influx of military and student veterans enrolling in postsecondary and graduate-level education programs. The role of the academic advisor has increased significantly with the influx of…

  14. 17 CFR 4.41 - Advertising by commodity pool operators, commodity trading advisors, and the principals thereof.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Advertising by commodity pool... ADVISORS Advertising § 4.41 Advertising by commodity pool operators, commodity trading advisors, and the... advertise in a manner which: (1) Employs any device, scheme or artifice to defraud any participant or client...

  15. Contextualizing Gay-straight Alliances: Student, Advisor, and Structural Factors Related to Positive Youth Development among Members

    Science.gov (United States)

    Poteat, V. Paul; Yoshikawa, Hirokazu; Calzo, Jerel P.; Gray, Mary L.; DiGiovanni, Craig D.; Lipkin, Arthur; Mundy-Shephard, Adrienne; Perrotti, Jeff; Scheer, Jillian R.; Shaw, Matthew P.

    2015-01-01

    Gay-straight alliances (GSAs) may promote resilience. Yet, what GSA components predict well-being? Among 146 youth and advisors in 13 GSAs (58% lesbian, gay, bisexual, or questioning; 64% White; 38% received free/reduced-cost lunch), student (demographics, victimization, attendance frequency, leadership, support, control), advisor (years served,…

  16. Structural and Thermochronological Constraints on the Coupling Between Exhumation, Denudation and Tectonics in the Himalaya: Insights From the Ama Drime Massif, Tibet- Nepal

    Science.gov (United States)

    Jessup, M. J.; Cottle, J. M.; Newell, D. L.; Berger, A. L.; Spotila, J. A.

    2007-12-01

    Focused denudation and mid-crustal flow are coupled in many active tectonic settings, including the Himalaya where exhumation of mid-crustal rocks is accommodated by thrust faults and low-angle detachment systems during crustal shortening. New structural data demonstrates that the most recently active tectonic feature in the Mt. Everest region is the Ama Drime Massif (ADM), a trans-Himalayan antiformal structure that protrudes ~ 70 km north from the crest of the Himalaya and displaces the South Tibetan Detachment system. Previous investigations interpreted the N-S striking shear zones and fault systems that bound either side of the ADM as the Main Central thrust. Our data show that these are 100-300 m thick normal-sense shear zones that are kinematically linked to young brittle faults that offset Quaternary deposits and record active E-W extension. Geochemical tracers in hot springs along the western shear zone indicate devolatilization of crustal rocks suggesting active metamorphism and/or melting beneath the ADM. Integration of high-to low-T thermochronometric methods, including U(-Th-)Pb, Apatite Fission Track and (U-Th)/He, yield important information regarding the timing and rate of exhumation of the ADM. These data reveal that rapid exhumation of material from the mid-crust during E-W extension began in the mid-Miocene and that a high rate of uplift / denudation persisted into the Pliocene. The southern end of the ADM is centered on the Arun River gorge, which previous geomorphological instigations defined as a prime candidate for climate-tectonic coupling. We combine our results with these exiting data to propose that active exhumation of deep crustal rocks of the ADM during E-W extension is coupled with denudation in the Arun River gorge. This model provides important quantitative constraints on the dynamic feedbacks between climate and tectonics in collisional orogens as well as the evolution of trans-Himalayan rivers and antiformal structures.

  17. Archives of Environmental Health, Volume 18 Number 4. Ninth AMA Air Pollution Medical Research Conference, Denver, July 22-24, 1968.

    Science.gov (United States)

    Barton, Frank

    Papers read before the Ninth American Medical Association (AMA) Air Pollution Medical Research Conference, Denver, Colorado, July 22-24, 1968, are presented in this document. Topics deal with the relationship and effects of atmospheric pollution to respiratory diseases, epidemiology, human physiological reactions, urban morbidity, health of school…

  18. The master two-dimensional gel database of human AMA cell proteins: towards linking protein and genome sequence and mapping information (update 1991)

    DEFF Research Database (Denmark)

    Celis, J E; Leffers, H; Rasmussen, H H;

    1991-01-01

    The master two-dimensional gel database of human AMA cells currently lists 3801 cellular and secreted proteins, of which 371 cellular polypeptides (306 IEF; 65 NEPHGE) were added to the master images during the last 10 months. These include: (i) very basic and acidic proteins that do not focus un...

  19. Construction of recombinant eukaryotic expression plasmid of AMA1 gene of Neospora caninum and its expression in Vero cells%犬新孢子虫AMA1基因重组真核表达质粒的构建及其在Vero细胞中的表达

    Institute of Scientific and Technical Information of China (English)

    郭焕平; 贾立军; 薛书江; 钱年超; 张守发

    2013-01-01

    为构建犬新孢子虫AMA1基因的重组真核表达质粒,了解其在Vero细胞中的表达情况,采用RT-PCR方法扩增牛源犬新孢子虫吉林株AMA1全长基因,构建了重组真核表达质粒pVAX1-NcAMA1;利用脂质体介导转染法将该重组质粒转染至Vero细胞,应用间接免疫荧光方法(IFA)和Western-blot技术检测AMA1基因在Vero细胞中的表达情况.结果显示,扩增的牛源犬新孢子虫吉林株AMA1基因的长度为1 695 bp,与GenBank中相应基因序列(AB265823.1)的同源性为99.9%.成功构建了重组真核表达质粒pVAX1-NcAMA1,IFA检测发现AMA1基因在Vero细胞中获得了瞬时表达,表达产物经Western-blot鉴定,其分子质量约为68 ku,且具有较好的反应原性.本试验为新孢子虫病核酸疫苗的进一步研究奠定了基础.%To construct recombinant eukaryotic expression plasmid of AMA1 gene of Neospora canihum and express it in Vero cells,the full-length fragment of NcAMA1 gene from bovine N.caninum Jilin strain was amplified by RT-PCR,and then subcloned into the expression vector pVAX-1 to construct a eukaryotic expression plasmid pVAX1-AMA1.The recombinant was then transfected into the Vero cells by liposome method.The expressed product in Vero cells was analyzed by indirect immunofluorescence assay (IFA) and Western-blot.The results showed that the amplified fragment was 1 695 bp,and shared 99.9% homology with the corresponding gene sequence in GenBank (AB265823.1).The recombinant eukaryotic expression plasmid pVAX1-AMA1 was successfully constructed.IFA result showed that the AMA1 gene was transiently expressed,and Western-blotting result showed that expressed product was 68 ku in molecular weight and had a positive reaction with anti-AMA1 serum.These results may provide a foundation for further studies on the development of nucleic acid vaccines against N.caninum infections.

  20. Sterile immunity to malaria after DNA prime/adenovirus boost immunization is associated with effector memory CD8+T cells targeting AMA1 class I epitopes.

    Directory of Open Access Journals (Sweden)

    Martha Sedegah

    Full Text Available BACKGROUND: Fifteen volunteers were immunized with three doses of plasmid DNA encoding P. falciparum circumsporozoite protein (CSP and apical membrane antigen-1 (AMA1 and boosted with human adenovirus-5 (Ad expressing the same antigens (DNA/Ad. Four volunteers (27% demonstrated sterile immunity to controlled human malaria infection and, overall, protection was statistically significantly associated with ELISpot and CD8+ T cell IFN-γ activities to AMA1 but not CSP. DNA priming was required for protection, as 18 additional subjects immunized with Ad alone (AdCA did not develop sterile protection. METHODOLOGY/PRINCIPAL FINDINGS: We sought to identify correlates of protection, recognizing that DNA-priming may induce different responses than AdCA alone. Among protected volunteers, two and three had higher ELISpot and CD8+ T cell IFN-γ responses to CSP and AMA1, respectively, than non-protected volunteers. Unexpectedly, non-protected volunteers in the AdCA trial showed ELISpot and CD8+ T cell IFN-γ responses to AMA1 equal to or higher than the protected volunteers. T cell functionality assessed by intracellular cytokine staining for IFN-γ, TNF-α and IL-2 likewise did not distinguish protected from non-protected volunteers across both trials. However, three of the four protected volunteers showed higher effector to central memory CD8+ T cell ratios to AMA1, and one of these to CSP, than non-protected volunteers for both antigens. These responses were focused on discrete regions of CSP and AMA1. Class I epitopes restricted by A*03 or B*58 supertypes within these regions of AMA1 strongly recalled responses in three of four protected volunteers. We hypothesize that vaccine-induced effector memory CD8+ T cells recognizing a single class I epitope can confer sterile immunity to P. falciparum in humans. CONCLUSIONS/SIGNIFICANCE: We suggest that better understanding of which epitopes within malaria antigens can confer sterile immunity and design of

  1. Navigating graduate school and beyond: A career guide for graduate students and a must read for every advisor

    Science.gov (United States)

    Schultz, Colin

    2012-05-01

    Beginning his scientific career as an engineering student at PSG College of Technology, in Coimbatore, India, Sundar A. Christopher has negotiated and navigated the higher-education system to become the chairman of the Department of Atmospheric Sciences at the University of Alabama in Huntsville. Drawing on his own experiences and on insights gleaned from the students who have passed through his graduate-level professional development course, Christopher takes a lighthearted look at peer review, proposal writing, managing budgets, and making the most of conferences in the AGU bookNavigating Graduate School and Beyond: A Career Guide for Graduate Students and a Must Read for Every Advisor. In this interview, Eos speaks to Christopher about overcoming the bureaucratic, logistical, and personal hurdles that too often lead students to disillusionment and conflict.

  2. 新孢子虫与弓形虫交叉抗原基因AMA1的克隆及原核表达载体构建%Clone and prokaryotic expression vector construction of Neospora caninum and Toxoplasma gondii AMA1 gene

    Institute of Scientific and Technical Information of China (English)

    孙婷婷; 金京顺; 贾立军

    2015-01-01

    为了解新孢子虫与弓形虫交叉抗原基因AMA1的生物学特性,应用PCR技术扩增新孢子虫/弓形虫AMA1基因,将PCR产物纯化回收后克隆于pMD18-T Simple Vector,构建pMD18-T-Nc/Tg AMA1重组克隆质粒,经PCR鉴定、酶切鉴定及测序分析后,亚克隆于原核表达载体pGEX-4T-1,构建重组原核表达质粒pGEX-4T-Nc/Tg AMA1,经PCR鉴定、酶切鉴定表明,构建的原核表达载体正确.该试验为新孢子虫/弓形虫AMA1基因重组疫苗的研究奠定了基础.

  3. 77 FR 43808 - Advisory Committee and Species Working Group Technical Advisor Appointment

    Science.gov (United States)

    2012-07-26

    ... National Oceanic and Atmospheric Administration RIN 0648-XC124 Advisory Committee and Species Working Group... nominations for technical advisors to the Advisory Committee's species working groups. DATES: Nominations must... working groups for the purpose of providing advice and recommendations to the U.S. Commissioners and...

  4. Bioenergy, Land Use Change and Climate Change Mitigation. Report for Policy Advisors and Policy Makers

    Energy Technology Data Exchange (ETDEWEB)

    Berndes, Goran [Chalmers Univ. of Technology (Sweden); Bird, Nell [Joanneum Research (Austria); Cowle, Annette [National Centre for Rural Greenhouse Gas Research (Australia)

    2010-07-01

    The report addresses a much debated issue - bioenergy and associated land use change, and how the climate change mitigation from use of bioenergy can be influenced by greenhouse gas emissions arising from land use change. The purpose of the report was to produce an unbiased, authoritative statement on this topic aimed especially at policy advisors and policy makers.

  5. Demographic Trends and Advocacy Experiences of Gay-Straight Alliance Advisors

    Science.gov (United States)

    Graybill, Emily C.; Varjas, Kris; Meyers, Joel; Dever, Bridget V.; Greenberg, Daphne; Roach, Andrew T.; Morillas, Catalina

    2015-01-01

    Using an ecological model, the individual-, school-, and sociocultural-level characteristics that affect gay-straight alliance (GSA) advisors were examined in the current study. The formation of GSAs has been one way that schools have sought to improve the school climate for lesbian, gay, bisexual, and transgender (LGBT) youth. Limited information…

  6. 78 FR 11909 - Emerging Global Advisors, LLC, et al.; Notice of Application

    Science.gov (United States)

    2013-02-20

    ... primarily in a non-diversified portfolio of equity securities traded in non-U.S. markets. 2. EGA, a Delaware... portfolios of the Funds (as defined below). Any Sub-Advisor will be registered under the Advisers Act. The... consist of a portfolio of securities (including fixed income securities and/or equity securities) and/or...

  7. 78 FR 23242 - President's Council of Advisors on Science and Technology (PCAST)

    Science.gov (United States)

    2013-04-18

    ... Administration research initiatives in neuroscience and technology's impact on productivity and employment... President's Council of Advisors on Science and Technology (PCAST) AGENCY: Office of Science, Department of... Technology (PCAST), and describes the functions of the Council. Notice of this meeting is required under...

  8. GENERAL CONSIDERATIONS ON INDUSTRIAL PROPERTY RIGHTS AND THE ROLE OF PATENT ADVISOR

    Directory of Open Access Journals (Sweden)

    Gabriel\tI.\tNĂSTASE

    2015-12-01

    Full Text Available Patent advisor must have extensive experience in industrial property activity in order to analyse together with the inventor of all aspects related to the invention, both during drafting documentation and during its review by the Office of Inventions, and then, throughout the period of validity of the patent.

  9. The role of religious advisors in mental health care in the World Mental Health surveys

    NARCIS (Netherlands)

    Kovess-Masfety, Vivianne; Evans-Lacko, Sara; Andrade, Laura Helena; Benjet, Corina; Ten Have, Margreet; Wardenaar, Klaas; Karam, Elie G; Bruffaerts, Ronny; Abdumalik, Jibril; Haro Abad, Josep Maria; Florescu, Silvia; Wu, Benjamin; De Jonge, Peter; Altwaijri, Yasmina; Hinkov, Hristo; Kawakami, Norito; Caldas-de-Almeida, Jose Miguel; Bromet, Evelyn; de Girolamo, Giovanni; Posada-Villa, José; Al-Hamzawi, Ali; Huang, Yueqin; Hu, Chiyi; Viana, Maria Carmen; Fayyad, John; Medina-Mora, Maria Elena; Demyttenaere, Koen; Lepine, Jean-Pierre; Murphy, Samuel; Xavier, Miguel; Takeshima, Tadashi; Gureje, Oye

    2016-01-01

    OBJECTIVES: To examine the role of religious advisors in mental health care (MHC) according to disorder severity, socio-demographics, religious involvement and country income groups. METHODS: Face to face household surveys in ten high income (HI), six upper-middle income (UMI) and five low/lower-mid

  10. Foreign Military Advisor Proficiency: The Need for Screening, Selection and Qualification

    Science.gov (United States)

    2009-06-12

    reinforce it. Although certain individuals seem to instinctively possess the requisite skill set, others must undergo extensive interpersonal ...Forces Advisor Guide (2008), highlights the additional interpersonal aspects that affect cohesion. “The most frequent complaints voiced by SF...ambiguity, realistic goal and task setting, open-mindedness, ability to withhold judgment, empathy, communicativeness, flexibility, curiosity, warmth

  11. Architects, Captains, and Dreamers: Creating Advisor Roles that Foster Youth-Adult Partnerships

    Science.gov (United States)

    Mitra, Dana; Lewis, Tiffanie; Sanders, Felicia

    2013-01-01

    While research has documented the many ways in which student voice can enable educational change, the process of how adults can help to enable student voice is less clear. This article examines how adults new to working as advisors of student voice initiatives begin to develop partnerships with young people. Using a Youth-Adult Partnership…

  12. Defining the Peer Advisor in the U.S. Study Abroad Context

    Science.gov (United States)

    Lo, Stephanie

    2006-01-01

    Peer advisor (PA) programs in study abroad offices have greatly increased in the past few years. Nevertheless, although many agree that PAs have many useful advantages, a clear definition of the PA within the study abroad context remains unavailable. Hence, the purpose of this pilot study is to find out how the PA is perceived by study abroad…

  13. 77 FR 42176 - Technical Amendment to Rules for the Temporary Registration of Municipal Advisors

    Science.gov (United States)

    2012-07-18

    ... Trading and Markets, Commission, 100 F Street NE., Washington, DC 20549-7010. SUPPLEMENTARY INFORMATION... COMMISSION 17 CFR Part 249 RIN 3235-AK69 Technical Amendment to Rules for the Temporary Registration of Municipal Advisors AGENCY: Securities and Exchange Commission. ACTION: Final rule; technical amendment...

  14. Connections versus Expertise of Legal Advisors, and Acquirers’ Failure to Learn

    NARCIS (Netherlands)

    Westbrock, B.; Weitzel, G.U.; Muehlfeld, K.

    2013-01-01

    Drawing on theories of social networks and organizational learning, we theorize about the importance that acquirers attribute to network-related and expertise-related factors in selecting legal advisors in international M&As. We also assess the outcome implications of these network-related and exper

  15. Correlation between Leadership Effectiveness and Personality Preferences at a Hungarian Independent Financial Advisor Company

    Science.gov (United States)

    Mészáros, Aranka; Budavári-Takács, Ildikó

    2016-01-01

    The main focus of our research is to study, with the help of the dimensions of the Myers-Briggs Type Indicator (hereinafter: MBTI) the personality preferences of those leaders at the financial advisor company who are successful already. In the present study first we introduce the preferences of MBTI. Then we go on to define our hypothesis…

  16. The Advisor as Servant: The Theoretical and Philosophical Relevance of Servant Leadership to Academic Advising

    Science.gov (United States)

    McClellan, Jeffrey L.

    2007-01-01

    Servant. This novel actively portrays Greenleaf's concept of servant leadership by describing the extracurricular work of a university professor. Consequently, some scholars have demonstrated the relevance of servant leadership to classroom instruction (Powers & Moore, 2005). However, it was not as an instructor, but as an advisor that the…

  17. A Case Study on Two Advisor-Advisee Relationships in a Master's TESOL Program in Taiwan

    Science.gov (United States)

    Chen, Cheryl Wei-yu

    2010-01-01

    Situated in an MA TESOL program in a large Taiwanese university, this study is a qualitative case study on two advising relationships. Three central issues were examined closely: (a) the nature of the advising relationships; (b) the challenges students encountered in the process of completing their theses; and (c) the advisors and advisee's…

  18. Use of Appreciative Inquiry to Explore the Experiences of Faculty Advisors

    Science.gov (United States)

    Myers, Valerie Ann-Marie

    2013-01-01

    Academic advising significantly impacts student achievement, persistence, and retention, yet it continues to be an area of weakness for many institutions. The purpose of this sequential mixed-methods case study was to explore the experiences of faculty advisors to identify strengths and weaknesses in their knowledge and skills. Appreciative…

  19. The Moderating Effect of Personality Traits on Advisor Relationships in Predicting Doctoral Student Burnout

    Science.gov (United States)

    Kosh, Emily P.

    2014-01-01

    Personality affects relationships. During the doctoral education, the second most important factor in degree completion, after financial support, is the student-advisor relationship. Approximately half of doctoral students do not finish their degrees. While it is known mentors have a profound impact on the success of doctoral students, the effect…

  20. 76 FR 62871 - President's Council of Advisors on Science and Technology Meeting

    Science.gov (United States)

    2011-10-11

    ... TECHNOLOGY POLICY President's Council of Advisors on Science and Technology Meeting AGENCY: Office of Science... Science and Technology (PCAST) is an advisory group of the nation's leading scientists and engineers, appointed by the President to augment the science and technology advice available to him from inside...

  1. 77 FR 54571 - President's Board of Advisors on Historically Black Colleges and Universities

    Science.gov (United States)

    2012-09-05

    ..., business, government, military, homeland- security, and education communities in a national dialogue...-54572] [FR Doc No: 2012-21853] DEPARTMENT OF EDUCATION President's Board of Advisors on Historically... Universities (Board), U.S. Department of Education. ACTION: Notice of an open meeting. SUMMARY: This...

  2. A Community Health Advisor Program to Reduce Cardiovascular Risk among Rural African-American Women

    Science.gov (United States)

    Cornell, C. E.; Littleton, M. A.; Greene, P. G.; Pulley, L.; Brownstein, J. N.; Sanderson, B. K.; Stalker, V. G.; Matson-Koffman, D.; Struempler, B.; Raczynski, J. M.

    2009-01-01

    The Uniontown, Alabama Community Health Project trained and facilitated Community Health Advisors (CHAs) in conducting a theory-based intervention designed to reduce the risk for cardiovascular disease (CVD) among rural African-American women. The multiphased project included formative evaluation and community organization, CHA recruitment and…

  3. The role of religious advisors in mental health care in the World Mental Health surveys

    NARCIS (Netherlands)

    Kovess-Masfety, Vivianne; Evans-Lacko, Sara; Andrade, Laura Helena; Benjet, Corina; Ten Have, Margreet; Wardenaar, Klaas; Karam, Elie G; Bruffaerts, Ronny; Abdumalik, Jibril; Haro Abad, Josep Maria; Florescu, Silvia; Wu, Benjamin; De Jonge, Peter; Altwaijri, Yasmina; Hinkov, Hristo; Kawakami, Norito; Caldas-de-Almeida, Jose Miguel; Bromet, Evelyn; de Girolamo, Giovanni; Posada-Villa, José; Al-Hamzawi, Ali; Huang, Yueqin; Hu, Chiyi; Viana, Maria Carmen; Fayyad, John; Medina-Mora, Maria Elena; Demyttenaere, Koen; Lepine, Jean-Pierre; Murphy, Samuel; Xavier, Miguel; Takeshima, Tadashi; Gureje, Oye

    OBJECTIVES: To examine the role of religious advisors in mental health care (MHC) according to disorder severity, socio-demographics, religious involvement and country income groups. METHODS: Face to face household surveys in ten high income (HI), six upper-middle income (UMI) and five

  4. Between Two Advisors: Interconnecting Academic and Workplace Settings in an Emerging Field

    Science.gov (United States)

    Hytönen, Kaisa; Palonen, Tuire; Lehtinen, Erno; Hakkarainen, Kai

    2016-01-01

    This article examines a new training design for continuing professional development that aims to support the learning of the novel knowledge and skills needed in emerging professional fields by interconnecting academic and workplace settings. The training design is based on using two advisors, one from working life and the other from an academic…

  5. Demographic Trends and Advocacy Experiences of Gay-Straight Alliance Advisors

    Science.gov (United States)

    Graybill, Emily C.; Varjas, Kris; Meyers, Joel; Dever, Bridget V.; Greenberg, Daphne; Roach, Andrew T.; Morillas, Catalina

    2015-01-01

    Using an ecological model, the individual-, school-, and sociocultural-level characteristics that affect gay-straight alliance (GSA) advisors were examined in the current study. The formation of GSAs has been one way that schools have sought to improve the school climate for lesbian, gay, bisexual, and transgender (LGBT) youth. Limited information…

  6. Reframing Doctoral Programs: A Program of Human Inquiry for Doctoral Students and Faculty Advisors.

    Science.gov (United States)

    Shambaugh, R. Neal

    2000-01-01

    Proposes the Program of Human Inquiry as a framework for joint student-faculty portfolios by graduate students and faculty advisors. The program consists of four components: (1) acknowledgment of what one brings to graduate studies; (2) a plan of study, (3) a record of rigorous negotiated "avenues of inquiry," and (4) ongoing discussion of values…

  7. The influence of TripAdvisor portal on hotel bussines in Serbia

    Directory of Open Access Journals (Sweden)

    Čačić Krunoslav

    2013-01-01

    Full Text Available Numerous researches have shown the existence of influence of specialized Web 2.0 portals on hotel business. One of most famous portals of that kind is TripAdvisor. The goal of this work is to determine the degree and mode of representation of hotels in Serbia on TripAdvisor portal. The results of the conducted research show that in past years the number of hotels from Serbia represented on this portal has increased significantly. At the end of 2012 there have been registered 3.288 comments which evaluated the service quality of 165 hotels from Serbia. The average vote, on five-degree scale, calculated at the level of all represented hotels at the end of 2012 was 3,92. Considering that Belgrade represents the primarily business, administrative and touristic center of Serbia, on the Belgrade's hotels specimen there has been analyzed the connection between business performances of hotels expressed through indicator TREVPAR and their image on TripAdvisor expressed through average vote determined based on user's comments, as well as in relation with TripAdvisor Popularity Index (TPI. The results show the high degree of correlation between analyzed features on the specimen of Belgrade's hotels, in range of hotels of second (4* and third category (3*. Having in mind the results of conducted research it is obvious that the hotels managers from Serbia should adopt and implement the corresponding procedures of monitoring and adequate reactions on contents on TripAdvisor, considering their influence on behavior of modern consumer in hotels.

  8. CARACTERIZACIÓN DE PÉPTIDOS DE ALTA UNIÓN DE LA PROTEINA AMA-1 MEDIANTE LA PROBABILIDAD Y LA ENTROPÍA

    Directory of Open Access Journals (Sweden)

    Javier Rodriguez

    2011-04-01

    Full Text Available

    Resumen

     

    La probabilidad y la entropía han sido empleadas para caracterizar física y matemáticamente péptidos de alta unión de proteínas de malaria al eritrocito. Estudios sugieren que la proteína AMA- 1 del Plasmodium Falciparum se une al eritrocito posiblemente jugando un papel en la infección. 

    Se efectuó una cuantificación de la frecuencia de aparición de los 20 aminoácidos esenciales en cada una de las posiciones de los péptidos de 20 residuos que constituyen la proteína AMA-1, a partir de la construcción de un espacio de probabilidad no equiprobable, y se calcularon los valores de probabilidad, sumatoria de probabilidad y entropía para cada una de las secuencias peptídicas. 

    Se encontró que los valores de probabilidad, sumatoria de probabilidad y entropía para las secuencias que no se unen varían entre los valores asociados al macroestado de no unión, mientras que dichos valores para las secuencias específicas de unión comprobadas experimentalmente se encuentran fuera de dichos rangos, conformando rangos específicos diferenciados asociados al  macroestado de unión. 

    Se diferenciaron secuencias de unión y de no unión con la metodología empleada, acertando en el 100% de los casos estudiados, caracterizando así los péptidos de AMA-1 de una forma objetiva y reproducible, y evidenciando un orden físicomatemático subyacente al fenómeno de unión.

    Palabras claveAMA-1, Probabilidad, Entropía, Unión, Eritrocito.

     

    Abstract

    HIGH BINDING PEPTIDES CHARACTERIZATION OF AMA-1 PROTEIN THROUGH PROBABILITY AND ENTROPY 

    Probability and Entropy have been

  9. DNA prime/Adenovirus boost malaria vaccine encoding P. falciparum CSP and AMA1 induces sterile protection associated with cell-mediated immunity.

    Directory of Open Access Journals (Sweden)

    Ilin Chuang

    Full Text Available BACKGROUND: Gene-based vaccination using prime/boost regimens protects animals and humans against malaria, inducing cell-mediated responses that in animal models target liver stage malaria parasites. We tested a DNA prime/adenovirus boost malaria vaccine in a Phase 1 clinical trial with controlled human malaria infection. METHODOLOGY/PRINCIPAL FINDINGS: The vaccine regimen was three monthly doses of two DNA plasmids (DNA followed four months later by a single boost with two non-replicating human serotype 5 adenovirus vectors (Ad. The constructs encoded genes expressing P. falciparum circumsporozoite protein (CSP and apical membrane antigen-1 (AMA1. The regimen was safe and well-tolerated, with mostly mild adverse events that occurred at the site of injection. Only one AE (diarrhea, possibly related to immunization, was severe (Grade 3, preventing daily activities. Four weeks after the Ad boost, 15 study subjects were challenged with P. falciparum sporozoites by mosquito bite, and four (27% were sterilely protected. Antibody responses by ELISA rose after Ad boost but were low (CSP geometric mean titer 210, range 44-817; AMA1 geometric mean micrograms/milliliter 11.9, range 1.5-102 and were not associated with protection. Ex vivo IFN-γ ELISpot responses after Ad boost were modest (CSP geometric mean spot forming cells/million peripheral blood mononuclear cells 86, range 13-408; AMA1 348, range 88-1270 and were highest in three protected subjects. ELISpot responses to AMA1 were significantly associated with protection (p = 0.019. Flow cytometry identified predominant IFN-γ mono-secreting CD8+ T cell responses in three protected subjects. No subjects with high pre-existing anti-Ad5 neutralizing antibodies were protected but the association was not statistically significant. SIGNIFICANCE: The DNA/Ad regimen provided the highest sterile immunity achieved against malaria following immunization with a gene-based subunit vaccine (27%. Protection

  10. Frequent use of an automated bolus advisor improves glycemic control in pediatric patients treated with insulin pump therapy: results of the Bolus Advisor Benefit Evaluation (BABE) study.

    Science.gov (United States)

    Ziegler, Ralph; Rees, Christen; Jacobs, Nehle; Parkin, Christopher G; Lyden, Maureen R; Petersen, Bettina; Wagner, Robin S

    2016-08-01

    The relationship between frequency and sustained bolus advisor (BA) use and glycemic improvement has not been well characterized in pediatric populations. The objective of this study is to assess the impact of frequent and persistent BA use on glycemic control among pediatric type 1 diabetes patients. In this 6-month, single-center, retrospective cohort study, 104 children [61 girls, mean age: 12.7 yr, mean HbA1c 8.0 (1.6)% [64 (17.5) mmol/mol

  11. Cho Abelian decomposition to the exact A-M-A solutions of the SU(2) Yang-Mills-Higgs theory

    Science.gov (United States)

    Wong, Khai-Ming; Teh, Rosy; Tie, Timothy

    2015-04-01

    We consider Cho Abelian decomposition to the exact A-M-A configurations in the SU(2) Yang-Mills-Higgs theory. The non-Abelian Yang-Mills gauge potential is decomposed into the restricted and the valence part. With the decomposition, the complete Abelian picture that draws to the various monopoles configurations can be seen clearly. The singularities for the two accompanying antimonopoles and the vortex ring are removed by the corresponding valence potential. However the singularity of the composite monopole at the origin is not removed, but strengthened. Hence the composite monopole is a different kind of monopole entity. Elsewhere, the plane singularity in the solution is not readily be removed by the valence potential. On the other hand, we also solve the decomposed equations to study the solutions that lead to the spatial infinity boundary conditions of the various numerical monopoles configurations. The decomposed equations are also solved in the near-origin region for exact solutions and their properties such as the magnetic field are plotted, which confirms the correspondence with their properties at the near infinity region.

  12. Genetic polymorphism and effect of natural selection at domain I of apical membrane antigen-1 (AMA-1) in Plasmodium vivax isolates from Myanmar.

    Science.gov (United States)

    Moon, Sung-Ung; Na, Byoung-Kuk; Kang, Jung-Mi; Kim, Jung-Yeon; Cho, Shin-Hyeong; Park, Yun-Kyu; Sohn, Woon-Mok; Lin, Khin; Kim, Tong-Soo

    2010-05-01

    Malaria is endemic or hypoendemic in Myanmar and the country still contributes to the high level of malaria deaths in South-East Asia. Although information on the nature and extent of population diversity within malaria parasites in the country is essential not only for understanding the epidemic situation but also to establish a proper control strategy, very little data is currently available on the extent of genetic polymorphisms of the malaria parasites in Myanmar. In this study, we analyzed the genetic polymorphism and natural selection at domain I of the apical membrane antigen-1 (AMA-1) among Plasmodium vivax Myanmar isolates. A total of 34 distinguishable haplotypes were identified among the 76 isolates sequenced. Comparison with the previously available PvAMA-1 sequences in the GenBank database revealed that 21 of them were new haplotypes that have never been reported till date. The difference between the rate of nonsynonymous (dN) and synonymous (dS) mutations was positive (dN-dS, 0.013+/-0.005), suggesting the domain I is under positive natural selection. The Tajima's D statistics was found to be -0.74652, suggesting that the gene has evolved under population size expansion and/or positive selection. The minimum recombination events were also high, indicating that recombination may occur within the domain I resulting in allelic diversity of PvAMA-1. Our results collectively suggest that PvAMA-1 displays high genetic polymorphism among Myanmar P. vivax isolates with highly diversifying selection at domain I. These results have significant implications in understanding the nature of P. vivax population circulating in Myanmar as well as providing useful information for malaria vaccine development based on this antigen.

  13. Adenovirus-5-Vectored P. falciparum Vaccine Expressing CSP and AMA1. Part B: Safety, Immunogenicity and Protective Efficacy of the CSP Component

    Science.gov (United States)

    2011-10-01

    recombi - nant AMA1 protein is protective in non-human primates[28], and has proven safe and immunogenic in Phase 1 studies in humans...2007) Extended immunization intervals enhance the immunogenicity and protective efficacy of plasmid DNA vaccines. Microbes Infect 9: 1439–1446. 36...Sedegah M, Hoffman SL (2006) Immunological responses of neonates and infants to DNA vaccines. Methods Mol Med 127: 239–251. 37. Wang R, Epstein J

  14. What secondary school career advisors in New Zealand Know about pharmacy and how that knowledge affects student career choices

    National Research Council Canada - National Science Library

    Aspden, Trudi; Cooper, Rachel; Liu, Yue; Marowa, Munyaradzi; Rubio, Christine; Waterhouse, Elisabeth-Jane; Sheridan, Janie

    2015-01-01

    To explore what career advisors at secondary schools (high schools) in New Zealand know about the pharmacy profession, how they obtain that knowledge, and what their potential influence is on students' decisions to study pharmacy...

  15. 78 FR 21349 - Meeting of the Board of Advisors to the Presidents of the Naval Postgraduate School and Naval War...

    Science.gov (United States)

    2013-04-10

    ... and Naval War College, Naval Postgraduate School Subcommittee AGENCY: Department of the Navy, DoD... also through the Board of Advisors (BOA) to the Presidents of NPS and Naval War College report on...

  16. The effects of AIDS prevention programs by lay health advisors for migrants in The Netherlands.

    Science.gov (United States)

    Martijn, Carolien; de Vries, Nanne K; Voorham, Toon; Brandsma, Jeanine; Meis, Max; Hospers, Harm J

    2004-05-01

    Two studies describe the effectiveness of acquired immunodeficiency syndrome (AIDS) prevention programs by lay health advisors (LHAs) for migrants in The Netherlands. The effects of such AIDS programs were evaluated (Study 1) and compared with the effects of professional health advisors (PHAs, i.e. medical doctors or nurses) (Study 2). The first study concerned Turkish and Moroccan migrants and showed positive effects on knowledge, behavioral control, and social norm towards condom use. Iraqi refugees participated in the second study that concerned a direct comparison of LHA- and PHA-based programs. Both programs result in positive effects in terms of attitude change and knowledge, but the LHA program resulted in a stronger intention to discuss AIDS with children. Analyses predicting intention to use condoms provide evidence that LHA programs lead to a stronger relation between attitudes and intention. This suggests that LHA-based AIDS programs are more successful in inducing internally motivated intentions to safe sex practices, such as condom use.

  17. Building Rapport Between International Graduate Students and Their Faculty Advisors: Cross-Cultural Mentoring Relationships at the University of Guelph

    OpenAIRE

    Faiza Omar; James P. Mahone; Jane Ngobia; John FitzSimons

    2016-01-01

    Mentoring graduate students is very challenging, even when both the student and faculty have similar cultural values. Many international students have a different culture from that of Canadian. Their challenge is adapting to their new environment, and for their faculty advisors to understand and work well with them. This research explored the relationships, experience, and challenges of international graduate students and their faculty advisors at the University of Guelph, through focus group...

  18. Knowledge Sharing Among Tourists via Social Media: A Comparison Between Facebook and TripAdvisor

    OpenAIRE

    Okazaki Ono, Shintaro; Andreu, Luisa; Campo, Sara

    2016-01-01

    This paper examines tourists’ knowledge sharing behavior in social media. Based on social capital theory, we aim to examine the effects of three dimensions of social capital—structural (social interaction ties), cognitive (shared vision), and relational (trust)—for two different types of social media: Facebook and TripAdvisor. We propose a structural model that connects an antecedent (homophily) and a consequence (knowledge sharing through posting) of these main dimensions of social capital. ...

  19. Aviation Security Force Assistance: Joint General Purpose Forces as Air Advisors

    Science.gov (United States)

    2013-03-01

    David E. Thaler et al., Building Partner Health Capacity with U.S. Military Forces: Enhancing AFSOC Health Engagement Missions (Santa Monica, CA: RAND...language, and diplomacy.” 36 Similarly, the advisor must be careful to avoid demonstrating frustration with host nation personnel and must be...Africa. 12 USAFRICOM conducted the first APF event in Accra, Ghana in March, 2012, with participation of service members from Ghana , Togo, Benin

  20. Hotel assessment through social media: The case of TripAdvisor

    OpenAIRE

    Molinillo, Sebastian; Fernández-Morales, Antonio; Ximénez-de-Sandoval, Jose Luis; Coca-Stefaniak, Andres

    2016-01-01

    Hotel booking decisions are increasingly influenced by consumer feedback available on social media sites. Using data submitted by customers on TripAdvisor, this study analyzes the customer satisfaction ratings posted for 2,211 hotels. The study provides four key contributions to our knowledge on this subject. Firstly, a comparative analysis was conducted of customer ratings for hotels located on the Spanish coast and Portugal's southern coast. Secondly, significant differences were found in t...

    1. Foreign Security Force Advisor Training, Doctrine, and Manning for 2015 and Beyond

      Science.gov (United States)

      2016-03-01

      advisor team requirements on a scheduled rotation instead of short notice, mid- tour, temporary duty, or IA. Scheduled rotation supports the monitor’s...to rotate back home. As an officer, my experiences in the Maldives, Iraq, and Afghanistan took me on a completely different path. Unlike my...moved in; and sugar plantations were concentrated under American Control” (p. 150). The U.S. military deployed to the region when its investments

    2. The American Military Advisor: Dealing with Senior Foreign Officials in the Islamic World

      Science.gov (United States)

      2008-08-01

      leader accustomed to administering vast areas of land, significant budgets, and large numbers of people. He might sit on the floor , wear a turban and... floor , thumb his prayer beads, and listen to flute and drum music, the advisor should be adept at taking his boots off and resting cross-legged for a...salary structure set by regulation, or is it based on fees for service, on the order of American waiters and waitresses who receive only a token

    3. Lessons from the Past: Vital Factors Influencing Military Advisors in Korea, Vietnam, and Afghanistan

      Science.gov (United States)

      2012-03-01

      under the very odd conditions of Arabia, your practical work will not be as good as, perhaps, you think it is.11 Lawrence was writing specifically...Republic of Vietnam senior military officers, who were writing subsequent to the U.S. departure from Vietnam. They had little reason to be overly...and Christopher L. Vowels . The Human Dimension of Advising: An Analysis of Interpersonal, Linguistic, Cultural, and Advisory Aspects of the Advisor

    4. Hotel assessment through social media: The case of TripAdvisor

      OpenAIRE

      Molinillo, Sebastian; Fernández-Morales, Antonio; Ximénez-de-Sandoval, Jose Luis; Coca-Stefaniak, Andres

      2016-01-01

      Hotel booking decisions are increasingly influenced by consumer feedback available on social media sites. Using data submitted by customers on TripAdvisor, this study analyzes the customer satisfaction ratings posted for 2,211 hotels. The study provides four key contributions to our knowledge on this subject. Firstly, a comparative analysis was conducted of customer ratings for hotels located on the Spanish coast and Portugal's southern coast. Secondly, significant differences were found in t...

    5. Correlation Between Leadership Effectiveness and Personality Preferences at a Hungarian Independent Financial Advisor Company

      Directory of Open Access Journals (Sweden)

      Mészáros Aranka

      2016-02-01

      Full Text Available The main focus of our research is to study, with the help of the dimensions of the Myers-Briggs Type Indicator (hereinafter: MBTI the personality preferences of those leaders at the financial advisor company who are successful already. In the present study first we introduce the preferences of MBTI. Then we go on to define our hypothesis regarding the typical preferences of the leaders, focusing on the main leadership tasks of the company.

    6. New solutions in IT Monitoring: cAdvisor and Collectd

      CERN Document Server

      Makai, Jozsef

      2015-01-01

      IT Monitoring team constantly improves its solutions to provide reliable solutions and computation platforms for the whole organization. There is an increasing trend of using containers for the different computation platforms within CERNs IT department, so IT Monitoring team has to be ready to provide solutions for container monitoring. Therefore, the challenges of the student project were to find solutions for container monitoring which could be integrated to existing IT Monitoring systems for an easy adoption. When the solution was chosen, an initial prototype for the system had to be implemented, as well.

    7. Advisor's Guide to Study Abroad. CIEE Occasional Paper No. 19.

      Science.gov (United States)

      Baumann, Cecelia C.

      This guide for study abroad is designed for American college students, and addresses the following issues: (1) the differences between American and foreign university systems and the lack of language proficiency in American students wishing to study abroad; (2) the alternatives to enrolling in a foreign university; (3) the advantages of American…

    8. Crop advisors as climate information brokers: Building the capacity of US farmers to adapt to climate change

      Directory of Open Access Journals (Sweden)

      Maria Carmen Lemos

      2014-01-01

      Full Text Available This paper examines the role of crop advisors as brokers of climate information to support US corn farmers to adapt to climatic change. It uses quantitative data collected from a broad survey of crop advisors in the US Corn Belt to examine the factors that shape advisors’ use of (and willingness to provide climate information to their clients. Building upon a general model of climate information usability we argue that advisors’ willingness to provide climate advice to farmers is influenced by three main factors: their information seeking habits and behavior, their experience with innovation in the past, and how climate information interplays with other kinds of information that they provide—especially agronomic advice. We find that advisors’ willingness to provide climate related information depends both on factors at the individual and organizational level and on the type of advice they provide. First, at the individual and organizational levels, advisors who work in supportive organizations and who collaborate with other advisors are more likely to provide climate information. Second, advisors are more likely to provide climate information if it does not interfere with their main profit making business (e.g. provision of agronomic advice. Third, there is a significant positive relationship between trust in a greater number or sources of information and use of climate information. Fourth, the way advisors perceive short- and long-term risk also influences their willingness to provide climate information; the more concerned they are about long-term climate-related risks to farming, the more likely they are to provide (or want to provide advice based on climate information. Differently from other empirical work in the literature, our analytical model suggests that neither negative experiences with climate information in the past nor the high level of uncertainty characteristic of climate information appear to influence advisors

    9. Should Political Advisors Carry out the Work of Policemen?

      Institute of Scientific and Technical Information of China (English)

      2008-01-01

      China’s Lunar New Year holiday (February 6-12 this year)is the time for grand celebrations,and for people to take a rest after slogging tirelessly for a year.But for Meng Hao,a member of the Standing Committee of the Guangdong Provincial Committee of the Chinese People’s Political Consultative Conference(CPPCC),the local political advisory body,it did not turn out to be the quiet holiday he’d hoped for.His nightmare began when he lost 6,000 yuan ($845)in Shenzhen,a prosperous business hub in Guangdong,on February 9.Meng was angry because he thought the money could only have been stolen at the city’s rail- way station,where the security system has a reputation for being weak.However,what really riled Meng was that the police had

    10. DPS Planetary Science Graduate Programs Database for Students and Advisors

      Science.gov (United States)

      Klassen, David R.; Roman, Anthony; Meinke, Bonnie K.

      2016-10-01

      Several years ago the DPS Education committee decided that it should have an online resource that could help undergraduate students find graduate programs that could lead to a PhD with a focus in planetary science. It began in 2013 as a static page of information and evolved from there to a database-driven web site. Visitors can browse the entire list of programs or create a subset listing based on several filters. The site should be of use not only to undergraduates looking for programs, but also for advisers looking to help their students decide on their future plans. The reason for such a list is that "planetary science" is a heading that covers an extremely diverse set of disciplines. The usual case is that planetary scientists are housed in a discipline-placed department so that finding them is typically not easy—undergraduates cannot look for a Planetary Science department, but must (somehow) know to search for them in all their possible places. This can overwhelm even determined undergraduate student, and even many advisers!We present here the updated site and a walk-through of the basic features as well as some usage statistics from the collected web site analytics. We ask for community feedback on additional features to make the system more usable for them. We also call upon those mentoring and advising undergraduates to use this resource, and for program admission chairs to continue to review their entry and provide us with the most up-to-date information.The URL for our site is http://dps.aas.org/education/graduate-schools.

    11. Reference Value Advisor: a new freeware set of macroinstructions to calculate reference intervals with Microsoft Excel.

      Science.gov (United States)

      Geffré, Anne; Concordet, Didier; Braun, Jean-Pierre; Trumel, Catherine

      2011-03-01

      International recommendations for determination of reference intervals have been recently updated, especially for small reference sample groups, and use of the robust method and Box-Cox transformation is now recommended. Unfortunately, these methods are not included in most software programs used for data analysis by clinical laboratories. We have created a set of macroinstructions, named Reference Value Advisor, for use in Microsoft Excel to calculate reference limits applying different methods. For any series of data, Reference Value Advisor calculates reference limits (with 90% confidence intervals [CI]) using a nonparametric method when n≥40 and by parametric and robust methods from native and Box-Cox transformed values; tests normality of distributions using the Anderson-Darling test and outliers using Tukey and Dixon-Reed tests; displays the distribution of values in dot plots and histograms and constructs Q-Q plots for visual inspection of normality; and provides minimal guidelines in the form of comments based on international recommendations. The critical steps in determination of reference intervals are correct selection of as many reference individuals as possible and analysis of specimens in controlled preanalytical and analytical conditions. Computing tools cannot compensate for flaws in selection and size of the reference sample group and handling and analysis of samples. However, if those steps are performed properly, Reference Value Advisor, available as freeware at http://www.biostat.envt.fr/spip/spip.php?article63, permits rapid assessment and comparison of results calculated using different methods, including currently unavailable methods. This allows for selection of the most appropriate method, especially as the program provides the CI of limits. It should be useful in veterinary clinical pathology when only small reference sample groups are available.

    12. Science PhD career preferences: levels, changes, and advisor encouragement.

      Directory of Open Access Journals (Sweden)

      Henry Sauermann

      Full Text Available Even though academic research is often viewed as the preferred career path for PhD trained scientists, most U.S. graduates enter careers in industry, government, or "alternative careers." There has been a growing concern that these career patterns reflect fundamental imbalances between the supply of scientists seeking academic positions and the availability of such positions. However, while government statistics provide insights into realized career transitions, there is little systematic data on scientists' career preferences and thus on the degree to which there is a mismatch between observed career paths and scientists' preferences. Moreover, we lack systematic evidence whether career preferences adjust over the course of the PhD training and to what extent advisors exacerbate imbalances by encouraging their students to pursue academic positions. Based on a national survey of PhD students at tier-one U.S. institutions, we provide insights into the career preferences of junior scientists across the life sciences, physics, and chemistry. We also show that the attractiveness of academic careers decreases significantly over the course of the PhD program, despite the fact that advisors strongly encourage academic careers over non-academic careers. Our data provide an empirical basis for common concerns regarding labor market imbalances. Our results also suggest the need for mechanisms that provide PhD applicants with information that allows them to carefully weigh the costs and benefits of pursuing a PhD, as well as for mechanisms that complement the job market advice advisors give to their current students.

    13. Pain in amaXhosa Women Living With HIV/AIDS: Translation and Validation of the Brief Pain Inventory-Xhosa.

      Science.gov (United States)

      Parker, Romy; Jelsma, Jennifer; Stein, Dan J

      2016-01-01

      Pain has been reported as the second most commonly reported symptom in people living with HIV/AIDS. In South Africa, there are more than five million people living with HIV/AIDS. Approximately, two million belong to the Xhosa cultural group. The prevalence of pain in amaXhosa living with HIV/AIDS was unknown at the commencement of the study. A culturally appropriate, valid, and reliable instrument is required to measure pain and its impact in this population. The objectives of this article are to document the process of translation of the Brief Pain Inventory (BPI) into the BPI-Xhosa and to present the results of the validity and reliability testing of the instrument. A six-stage forward-backward translation process was followed using bilingual and bicultural translators to ensure decentering of the process. The translated BPI-Xhosa, a demographic questionnaire and the European Quality of Life-5 Dimensions Xhosa version (EQ-5D-Xhosa) health-related quality of life instrument were administered to 229 amaXhosa women living with HIV/AIDS in a resource-poor urban settlement in South Africa. A 74.24% (95% CI: 68.2-79.47) prevalence of pain was recorded. The BPI-Xhosa had good concurrent validity when compared with the previously validated EQ-5D-Xhosa. Factor analysis confirmed that the BPI-Xhosa had a two-factor structure (pain severity and pain interference). The instrument had good internal reliability, with Cronbach alphas of 0.77 and 0.83 for the pain severity and pain interference subscales, respectively. The BPI-Xhosa is a valid instrument which can be used to measure pain prevalence, severity, and interference in amaXhosa women living with HIV/AIDS. Copyright © 2016 American Academy of Hospice and Palliative Medicine. Published by Elsevier Inc. All rights reserved.

    14. Addition of CpG ODN to recombinant Pseudomonas aeruginosa ExoProtein A conjugates of AMA1 and Pfs25 greatly increases the number of responders.

      Science.gov (United States)

      Qian, Feng; Rausch, Kelly M; Muratova, Olga; Zhou, Hong; Song, Guanhong; Diouf, Ababacar; Lambert, Lynn; Narum, David L; Wu, Yimin; Saul, Allan; Miller, Louis H; Long, Carole A; Mullen, Gregory E D

      2008-05-12

      Both the blood-stage protein apical membrane antigen 1 (AMA1) and the 25-kDa sexual-stage protein (Pfs25) of Plasmodium falciparum are two leading candidates in malarial vaccine development. We have previously demonstrated that conjugation of these malarial antigens to recombinant Pseudomonas aeruginosa ExoProtein A (rEPA) significantly increased the mean-specific functional antibody responses in mice; however, some mice responded poorly and were unable to demonstrate a functional response. We hypothesized that the immunogenicities of these two malarial antigens could be further enhanced by the inclusion of a CpG oligodeoxynucleotide in the formulation. Mice were immunized with either rEPA-conjugated or unconjugated AMA1 and Pfs25 formulated on Alhydrogel with or without the addition of CPG 7909. Mice received the formulations on days 0 and 28, and mouse sera were collected on day 42. ELISA analyses on these sera showed that the addition of CPG 7909 to AMA1-rEPA and Pfs25-rEPA formulated on Alhydrogel induced significantly higher mean antibody titers than the formulations without CPG 7909, and led to a mixed Th1/Th2 response as demonstrated by the production of mouse IgG1 and IgG2a subclasses. The presence of CPG 7909 in the formulations of both conjugated antigens greatly increased the proportion of responders with antibody titers sufficient to inhibit blood-stage parasite growth in vitro or block transmission of sexual-stage parasites to mosquitoes. The results obtained in this study indicate the potential use of a combination strategy to increase the number of responders to malarial antigens in humans.

    15. Solution structure of a Plasmodium falciparum AMA-1/MSP 1 chimeric protein vaccine candidate (PfCP-2.9 for malaria

      Directory of Open Access Journals (Sweden)

      Jin Changwen

      2010-03-01

      Full Text Available Abstract Background The Plasmodium falciparum chimeric protein PfCP-2.9 is a promising asexual-stage malaria vaccine evaluated in clinical trials. This chimeric protein consists of two cysteine-rich domains: domain III of the apical membrane antigen 1 (AMA-1 [III] and the C-terminal region of the merozoite surface protein 1 (MSP1-19. It has been reported that the fusion of these two antigens enhanced their immunogenicity and antibody-mediated inhibition of parasite growth in vitro. Methods The 15N-labeled and 13C/15N-labeled PfCP-2.9 was produced in Pichia pastoris for nuclear magnetic resonance (NMR structure analysis. The chemical shift assignments of PfCP-2.9 were compared with those previously reported for the individual domains (i.e., PfAMA-1(III or PfMSP 1-19. The two-dimensional spectra and transverse relaxation rates (R2 of the PfMSP1-19 alone were compared with that of the PfCP-2.9. Results Confident backbone assignments were obtained for 122 out of 241 residues of PfCP-2.9. The assigned residues in PfCP-2.9 were very similar to those previously reported for the individual domains. The conformation of the PfMSP1-19 in different constructs is essentially the same. Comparison of transverse relaxation rates (R2 strongly suggests no weak interaction between the domains. Conclusions These data indicate that the fusion of AMA-1(III and MSP1-19 as chimeric protein did not change their structures, supporting the use of the chimeric protein as a potential malaria vaccine.

    16. Dean W. Edward Sell–Our Dedicated Law Review Advisor and Unwavering Support

      OpenAIRE

      Matthew E. Shames; Theodore A. Schroeder; Ira S. Nathenson; Bradley J. Martineau; Matthew H. Hawes; Shanda N. Hastings; Michele Sherretta

      2004-01-01

      Towards the end of my second year of law school, as I began to learn the ropes of my new position as Editor-in-Chief, I had several opportunities to sit down and talk with Dean Sell about the upcoming year. Although I never was a student of his in the classroom, I looked forward to working with the Law Review’s most senior faculty advisor. We discussed all sorts of ideas, large and small, for how to improve the Law Review. I looked on as he learned how to use a digital camera. I got to ...

    17. Perspective of the Science Advisor to the Waste Isolation Pilot Plant

      Energy Technology Data Exchange (ETDEWEB)

      WEART,WENDELL D.

      1999-09-03

      In 1975 Sandia National Laboratories (SNL) was asked by the predecessor to the Department of Energy to assume responsibility for the scientific programs necessary to assure the safe and satisfactory development of a geologic repository in the salt beds of southeast New Mexico. Sandia has continued in the role of Science Advisor to the Waste Isolation Pilot Plant (WIPP) to the present time. This paper will share the perspectives developed over the past 25 years as the project was brought to fruition with successful certification by the Environmental Protection Agency (EPA) on May 13, 1998 and commencement of operations on April 26, 1999.

    18. The life, times, and health care of Harry L Hopkins: Presidential advisor and perpetual patient.

      Science.gov (United States)

      Pappas, Theodore N; Swanson, Sven

      2016-06-24

      Harry Hopkins was the most important nontitled allied leader in World War II. He was the advisor to President Roosevelt who managed the diplomacy between Roosevelt, Churchill, and Stalin from 1941 to 1946. Throughout these times, Hopkins was ill and required transfusions, admissions to the hospital, and nutritional supplementation to keep him well enough to travel the world and manage the allied war diplomacy. There has been no unifying theory to account for all his symptoms and his reported pathologic and autopsy findings. In this paper, we will review his political and medical history and a differential diagnosis of his illness.

    19. Requirements for intermediaries and advisors in the area of mortgages resulting from Mortgage Credit Directive – implications for Poland

      Directory of Open Access Journals (Sweden)

      Krzysztof Waliszewski

      2015-10-01

      Full Text Available The dynamic development of the mortgage market, especially in the period before the current financial crisis, revealed that within the EU there are local mortgage credit markets and that it is necessary to harmonize the rules of the system and consumer protection within the Community. The intention of the creators of the Mortgage Credit Directive was to organize the mortgage lending market for residential purposes and make it transparent, as well as increase the safety of the consumer credit market, along the lines of what took place earlier in the consumer credit market regulations (The Consumer Credit Directives no. 2008/48/EC and earlier no. 87/102/EEC. The Mortgage Credit Directive implies for lenders - credit institutions to act at every stage of the lending process with respect to the consumer’s interest and to provide them with adequate services for their needs. Due to the large role of indirect distribution channels of mortgages by banks there are certain requirements for intermediaries, brokers and credit advisors. The implementation term of the Directive, appointed for March 2016, implies action to be taken in order to implement the provisions of this Directive into Polish law. The legislative process is being conducted by the Ministry of Finance and supported by the Group on implementation of the Mortgage Credit Directive operating with the Council of Financial Market Development.

    20. A Pulsed Power System Design Using Lithium-ion Batteries and One Charger per Battery

      Science.gov (United States)

      2009-12-01

      SYSTEM DESIGN USING LITHIUM-ION BATTERIES AND ONE CHARGER PER BATTERY by Frank E. Filler December 2009 Thesis Advisor: Alexander L. Julian...Author: Frank E. Filler Approved by: Alexander L. Julian Thesis Advisor Roberto Crisiti Second Reader Jeffrey B. Knorr Chairman...Battery Management System BNC Bayonet Neill -Concelman CC Constant Current CCCV Constant Current Constant Voltage CV Constant Voltage D

    1. Geometry-Of-Fire Tracking Algorithm for Direct-Fire Weapon Systems

      Science.gov (United States)

      2015-09-01

      NAVAL POSTGRADUATE SCHOOL MONTEREY, CALIFORNIA THESIS Approved for public release; distribution is unlimited GEOMETRY-OF- FIRE ...TRACKING ALGORITHM FOR DIRECT- FIRE WEAPON SYSTEMS by Caleb K. Khan September 2015 Thesis Advisor: Zachary Staples Co-Advisor: Xiaoping...2015 3. REPORT TYPE AND DATES COVERED Master’s Thesis 4. TITLE AND SUBTITLE GEOMETRY-OF- FIRE TRACKING ALGORITHM FOR DIRECT- FIRE WEAPON SYSTEMS

    2. Amas de casa, televisión y participación política. México, elecciones 2003

      Directory of Open Access Journals (Sweden)

      Aimée Vega Montiel

      2004-01-01

      Full Text Available A través de la metodología de la entrevista y partiendo de las preguntas: ¿cómo ven las amas de casa las noticias televisivas sobre las elecciones?; ¿por qué?; ¿para qué?, la autora analiza la frecuencia con la que este sector de la población femenina ve las noticias electorales en televisión así como la influencia que este medio ejerció sobre el comportamiento político-electoral durante el último proceso electoral en México (julio del 2003.

    3. Analysis of an advisor-advisee relationship: an exploratory study of the area of exact and Earth sciences in Brazil.

      Directory of Open Access Journals (Sweden)

      Esteban F Tuesta

      Full Text Available Scientific collaboration has been studied by researchers for decades. Several approaches have been adopted to address the question of how collaboration has evolved in terms of publication output, numbers of coauthors, and multidisciplinary trends. One particular type of collaboration that has received very little attention concerns advisor and advisee relationships. In this paper, we examine this relationship for the researchers who are involved in the area of Exact and Earth Sciences in Brazil and its eight subareas. These pairs are registered in the Lattes Platform that manages the individual curricula vitae of Brazilian researchers. The individual features of these academic researchers and their coauthoring relationships were investigated. We have found evidence that there exists positive correlation between time of advisor-advisee relationship with the advisee's productivity. Additionally, there has been a gradual decline in advisor-advisee coauthoring over a number of years as measured by the Kulczynski index, which could be interpreted as decline of the dependence.

    4. Money Advisor

      Institute of Scientific and Technical Information of China (English)

      2006-01-01

      Fan Gang, 52, a proponent of employing a tight monetary policy coupled with an expansionary macro-economic policy to stimulate China's domestic demand, has been appointed to the People's Bank of China's Monetary Policy Committee, as outside commissioner. The appointment,

    5. Oxytocin facilitation of acceptance of social advice is dependent upon the perceived trustworthiness of individual advisors.

      Science.gov (United States)

      Luo, Ruixue; Xu, Lei; Zhao, Weihua; Ma, Xiaole; Xu, Xiaolei; Kou, Juan; Gao, Zhao; Becker, Benjamin; Kendrick, Keith M

      2017-09-01

      The neuropeptide oxytocin may increase social cohesion by making us more willing to trust others and/or to conform to their opinions. Here we investigated whether intranasal oxytocin can influence acceptance of advice given on solving everyday social problems by either individual expert (psychologist) or non-expert advisors with or without influencing their perceived likeability or trustworthiness. In a double-blind, between-subject, placebo-control design study in 160 male and female subjects, intranasal oxytocin (24IU) only significantly enhanced acceptance of advice given by female psychologists who were rated as the most trustworthy advisors. However, oxytocin itself did not alter either trustworthiness or likeability ratings. The oxytocin effect on acceptance of the female psychologist's advice was not maintained after a week, with subjects mainly reverting to their original solutions. These findings suggest that while oxytocin can transiently increase acceptance of advice from the most trustworthy individuals this is because it makes subjects more likely to conform to their opinions rather than enhancing their perceived trustworthiness or likeability. Thus in every day contexts oxytocin may primarily promote social cohesion by facilitating conformity towards the opinions of the most trusted individuals. Copyright © 2017. Published by Elsevier Ltd.

    6. Combining viral vectored and protein-in-adjuvant vaccines against the blood-stage malaria antigen AMA1: report on a phase 1a clinical trial.

      Science.gov (United States)

      Hodgson, Susanne H; Choudhary, Prateek; Elias, Sean C; Milne, Kathryn H; Rampling, Thomas W; Biswas, Sumi; Poulton, Ian D; Miura, Kazutoyo; Douglas, Alexander D; Alanine, Daniel Gw; Illingworth, Joseph J; de Cassan, Simone C; Zhu, Daming; Nicosia, Alfredo; Long, Carole A; Moyle, Sarah; Berrie, Eleanor; Lawrie, Alison M; Wu, Yimin; Ellis, Ruth D; Hill, Adrian V S; Draper, Simon J

      2014-12-01

      The development of effective vaccines against difficult disease targets will require the identification of new subunit vaccination strategies that can induce and maintain effective immune responses in humans. Here we report on a phase 1a clinical trial using the AMA1 antigen from the blood-stage Plasmodium falciparum malaria parasite delivered either as recombinant protein formulated with Alhydrogel adjuvant with and without CPG 7909, or using recombinant vectored vaccines--chimpanzee adenovirus ChAd63 and the orthopoxvirus MVA. A variety of promising "mixed-modality" regimens were tested. All volunteers were primed with ChAd63, and then subsequently boosted with MVA and/or protein-in-adjuvant using either an 8- or 16-week prime-boost interval. We report on the safety of these regimens, as well as the T cell, B cell, and serum antibody responses. Notably, IgG antibody responses primed by ChAd63 were comparably boosted by AMA1 protein vaccine, irrespective of whether CPG 7909 was included in the Alhydrogel adjuvant. The ability to improve the potency of a relatively weak aluminium-based adjuvant in humans, by previously priming with an adenoviral vaccine vector encoding the same antigen, thus offers a novel vaccination strategy for difficult or neglected disease targets when access to more potent adjuvants is not possible.

    7. Cloning, Tissue Specific Expression and Bioinformatics Analysis of Goat Lysosomal α-AMA Gene%山羊溶酶体α-AMA基因的克隆、生物信息学及组织表达谱分析

      Institute of Scientific and Technical Information of China (English)

      孔祥雅; 李义; 程敏; 荆新堂; 李勤凡

      2012-01-01

      本研究旨在对山羊溶酶体α-甘露糖苷酶(α-AMA)基因进行组织表达谱和生物信息学分析.参考牛α-AMA基因序列设计引物,采用PCR技术克隆山羊α-AMA基因序列,并利用荧光定量RT-PCR进行组织表达谱分析以及进行生物信息学预测.首次获得了山羊α-AMA基因,含有完整CDS编码区3000 bp,编码999个氨基酸,其中前50个氨基酸为信号肽序列.其编码区的核苷酸序列和预测氨基酸序列与牛的α-AMA相似性最高,分别为95.93%和94.79%.组织表达谱分析表明α-AMA在山羊各组织均不同程度的表达,其中在肺脏、肝脏、小脑表达量较高.生物信息学预测发现,α-AMA蛋白属于糖苷水解酶38家族成员,有2个保守的结构域,存在9个N-糖基化位点.SWISS-MODEL同源建模山羊α-AMA具有良好的可信度.本研究为探讨酶的作用机理及疯草解毒剂的研制提供了理论依据.%Goat lysosomal a-AMA gene was amplified using RT-PCR and the tissue specific expression profile, bioinformatics characteristic of a-AMA were studied. Primers were designed based on the sequence of bovine lysosomal a-AMA gene and were used in amplifying the goat a-AMA, the tissue specific expression profile was analyzed by qRT-PCR, and the bioinformatics analysis of a-AMA was conducted. The results showed that CDS sequence of goat a-AMA was 3 000 bp, encoding a deduced protein containing 999 amino acid residues in which the first 50 residues were signal peptide, and this nucleotide sequence of CDS and the deduced amino acids shared 95. 93% and 94. 79% homology with the a-AMA mRNA of cattle. The qRT-PCR revealed that the a-AMA gene was expressed in various tissues at different levels. The expression level of this gene was higher in the lung, liver, and cerebellum. It was predicted that a-AMA was belonged to Glycosyl hydrolases family 38, and composed of two conserved domains. There were thirty-five phosphorylation sites, one phosphorylation site of

    8. El aroma como un atributo influyente en el proceso de decisión de compra de papel higiénico en amas de casa en la ciudad de Guayaquil.

      OpenAIRE

      Paz Anzules, Joseph Leopoldo

      2016-01-01

      Este proyecto tiene como finalidad determinar la importancia del aroma como atributo motivador de compra en el ama de casa guayaquileña, conocer cuáles son los atributos más importantes, determinar si existe alguna asociación de marca a través de ese atributo y cuál es el tipo de perfil que presenta el grupo objetivo de consumidoras. El trabajo investigativo se combinó entre enfoques cuantitativos y cualitativos que permitieron tener una perspectiva clara de la percepción del ama de...

    9. What secondary school career advisors in New Zealand Know about pharmacy and how that knowledge affects student career choices.

      Science.gov (United States)

      Aspden, Trudi; Cooper, Rachel; Liu, Yue; Marowa, Munyaradzi; Rubio, Christine; Waterhouse, Elisabeth-Jane; Sheridan, Janie

      2015-02-17

      To explore what career advisors at secondary schools (high schools) in New Zealand know about the pharmacy profession, how they obtain that knowledge, and what their potential influence is on students' decisions to study pharmacy. This study employed a cross sectional questionnaire design. A postal questionnaire was sent to 250 randomly selected secondary schools in New Zealand. The response rate was 112/248 (45%). Responding career advisors were familiar with many of the roles of pharmacists (mean knowledge score 11.5 out of 16). Over 90% of career advisors were familiar with the roles of pharmacists in the community setting; however, many had a poorer understanding of other pharmacist roles. One suggestion for improving the promotion of pharmacy within secondary schools was a greater involvement of pharmacists and pharmacy students in the promotion of pharmacy as a profession. Career advisors need a broader understanding of the potential roles of pharmacists. Increasing contact from practicing pharmacists and undergraduate pharmacy students are potential ways of increasing student interest in pharmacy.

    10. 77 FR 60732 - PACE Select Advisors Trust and UBS Global Asset Management (Americas) Inc.; Notice of Application

      Science.gov (United States)

      2012-10-04

      ... COMMISSION PACE Select Advisors Trust and UBS Global Asset Management (Americas) Inc.; Notice of Application... Global Asset Management (Americas) Inc. (the ``Adviser'') (collectively, ``Applicants''). Filing Dates... Global Asset Management (Americas) Inc., 1285 Avenue of the Americas, New York, NY 10019-6028....

    11. The Effects of Task Clarification, Feedback, and Goal Setting on Student Advisors' Office Behaviors and Customer Service

      Science.gov (United States)

      Tittelbach, Danielle; DeAngelis, Maureen; Sturmey, Peter; Alvero, Alicia M.

      2007-01-01

      This study evaluated the effects of feedback, task clarification and goal-setting on office behaviors and customer service of ten undergraduate participants that served as university advisors. A multiple baseline design was implemented across three target behaviors: client greeting, front-desk behaviors, and punctuality. During intervention the…

    12. Fostering Academic Self-Concept: Advisor Support and Sense of Belonging among International and Domestic Graduate Students

      Science.gov (United States)

      Curtin, Nicola; Stewart, Abigail J.; Ostrove, Joan M.

      2013-01-01

      International doctoral students in the United States face challenges of acculturation in academia yet complete graduate school at higher rates and more quickly than their domestic counterparts. This study examined advisor support, sense of belonging, and academic self-concept among international and domestic doctoral students at a research…

    13. 77 FR 37079 - Versus Capital Multi-Manager Real Estate Income Fund LLC and Versus Capital Advisors; Notice of...

      Science.gov (United States)

      2012-06-20

      ...; File No. 812-14008] Versus Capital Multi-Manager Real Estate Income Fund LLC and Versus Capital...-Manager Real Estate Income Fund LLC (``Initial Fund'') and Versus Capital Advisors LLC (``Adviser... to achieve its objectives by investing in funds that invest indirectly in real estate and by...

    14. "Good Practice" School Advisors in Greek Education: The Difficulty in Linking Collaborative Networks, Communities of Practice and Quality Culture

      Science.gov (United States)

      Stamelos, Georgios; Bartzakli, Marianna

      2013-01-01

      Quality in education is considered to be a central aim as far as the formation and the implementation of educational policy worldwide is concerned. The basic prerequisite for it, though, is quality culture. Collaborative networks between school advisors and primary school teachers are examined to reveal how they can affect the formation of…

    15. Building Rapport between International Graduate Students and Their Faculty Advisors: Cross- Cultural Mentoring Relationships at the University of Guelph

      Science.gov (United States)

      Omar, Faiza; Mahone, James P.; Ngobia, Jane; FitzSimons, John

      2016-01-01

      Mentoring graduate students is very challenging, even when both the student and faculty have similar cultural values. Many international students have a different culture from that of Canadian. Their challenge is adapting to their new environment, and for their faculty advisors to understand and work well with them. This research explored the…

    16. "Good Practice" School Advisors in Greek Education: The Difficulty in Linking Collaborative Networks, Communities of Practice and Quality Culture

      Science.gov (United States)

      Stamelos, Georgios; Bartzakli, Marianna

      2013-01-01

      Quality in education is considered to be a central aim as far as the formation and the implementation of educational policy worldwide is concerned. The basic prerequisite for it, though, is quality culture. Collaborative networks between school advisors and primary school teachers are examined to reveal how they can affect the formation of…

    17. The Honors Thesis: A Handbook for Honors Directors, Deans, and Faculty Advisors. National Collegiate Honors Council Monograph Series

      Science.gov (United States)

      Anderson, Mark; Lyons, Karen; Weiner, Norman

      2014-01-01

      This handbook is intended to help all those who design, administer, and implement honors thesis programs--honors directors, deans, staff, faculty, and advisors--evaluate their thesis programs, solve pressing problems, select more effective requirements or procedures, or introduce an entirely new thesis program. The authors' goal is to provide…

    18. Are Advisors an Asset or Redundant in SME Mergers and Acquisitions? : Evidence from North-West Europe

      NARCIS (Netherlands)

      Teeffelen, Lex van

      2011-01-01

      Paper presented at the RENT XXV conference. The point of this paper is to improve our understanding on the added value of M&A advisors in SMEs, an important segment of the economy and merger industry. To predict the added value of professional advice we contrast two theories: the agency theory and

    19. Using CBT with Anxious Language Learners: The Potential Role of the Learning Advisor

      Directory of Open Access Journals (Sweden)

      Neil Curry

      2014-01-01

      Full Text Available Foreign Language Anxiety (FLA can be a crippling condition for many students, preventing them from taking an active part in the classroom, and also retarding their L2 use in wider communicative situations. Providing learners with the tools to overcome anxiety on an individual basis is an area which needs further investigation. Cognitive Behaviour Therapy (CBT is a widespread counselling practice used to treat anxieties. It shares similarities with some techniques employed in Advising in Language Learning (ALL for helping students with language goals, and it is worthwhile investigating and raising awareness of how it can be used for FLA. The article describes major characteristics of FLA and also CBT, and then describes four functions which CBT and ALL share: goal-setting, guided discovery, Socratic questioning and use of reflection. Preliminary research also demonstrates how some of the practices associated with CBT could be applied by Learning Advisors to help students to overcome FLA.

    20. PROTECT: Proximity-based Trust-advisor using Encounters for Mobile Societies

      CERN Document Server

      Kumar, Udayan; Helmy, Ahmed

      2010-01-01

      Many interactions between network users rely on trust, which is becoming particularly important given the security breaches in the Internet today. These problems are further exacerbated by the dynamics in wireless mobile networks. In this paper we address the issue of trust advisory and establishment in mobile networks, with application to ad hoc networks, including DTNs. We utilize encounters in mobile societies in novel ways, noticing that mobility provides opportunities to build proximity, location and similarity based trust. Four new trust advisor filters are introduced - including encounter frequency, duration, behavior vectors and behavior matrices - and evaluated over an extensive set of real-world traces collected from a major university. Two sets of statistical analyses are performed; the first examines the underlying encounter relationships in mobile societies, and the second evaluates DTN routing in mobile peer-to-peer networks using trust and selfishness models. We find that for the analyzed trace...

    1. Parabolic Trough Reference Plant for Cost Modeling with the Solar Advisor Model (SAM)

      Energy Technology Data Exchange (ETDEWEB)

      Turchi, C.

      2010-07-01

      This report describes a component-based cost model developed for parabolic trough solar power plants. The cost model was developed by the National Renewable Energy Laboratory (NREL), assisted by WorleyParsons Group Inc., for use with NREL's Solar Advisor Model (SAM). This report includes an overview and explanation of the model, two summary contract reports from WorleyParsons, and an Excel spreadsheet for use with SAM. The cost study uses a reference plant with a 100-MWe capacity and six hours of thermal energy storage. Wet-cooling and dry-cooling configurations are considered. The spreadsheet includes capital and operating cost by component to allow users to estimate the impact of changes in component costs.

    2. Review of "The Client Connection: How Advisors can Build Bridges that Last"

      Directory of Open Access Journals (Sweden)

      Jack Reilley

      2010-10-01

      Full Text Available In their book titled The Client Connection: How Advisors Can Build Bridges That Last, Olivia Mellan and Sherry Christie have done an outstanding and comprehensive job of addressing important current issues affecting the financial planning profession. Although not a long book, the authors are able to comprehensively address topics associated with client relationship building. Their writing style is accessible and offered for consideration in a context appropriate to novice and seasoned professionals alike. While there are 23 chapters in total, the material is organized under seven headings that form the overarching framework for the material presented. Overall, in the opinion of this reviewer, the authors did a nice job of connecting various ideas and concepts that might otherwise have seemed disconnected without this framework. The following review provides a glimpse of each section of the book.

    3. 近十年我国辅导员研究的主题分析--对 CNKI“辅导员”高被引论文(2005-2014年)的内容调查%Subject Analysis of Research on College Advisors'Work in the Last Decade

      Institute of Scientific and Technical Information of China (English)

      徐芝兰

      2016-01-01

      对“辅导员”高频被引论文的内容分析结果显示,我国“辅导员”研究的主题依次聚焦于辅导员队伍的专业化、职业化、专家化建设,高校辅导员队伍建设的一般性探讨,辅导员角色和职责定位,辅导员素质、能力及考核,辅导员职业倦怠的表现、成因与对策,辅导员工作开展的方式、方法,高校辅导员制度的历史演变等方面。但存有同一主题下研究内容近似度高,学术原创性较低;研究范式过于单一;解决策略可操作性欠缺等问题。%Content analysis of highly cited papers that are authored by college advisors shows the sub-jects that are mostly dealt with are:the professionalization and specialization of college advisors,gen-eral discussion of the team construction,role definition and function orientation of advisors,their quality,competence and evaluation,signs and causes of job burnout they experience and solutions to it,the ways college advisors are doing their job,and the evolution of the college advisors system in China.Problems with the research include high degree of approximation,low academic originality, lack of variety in the research paradigm and poor operability of suggested solutions.

    4. FOTOGRAFÍAS DE AMAS DE LECHE EN BAHÍA. EVIDENCIA VISUAL DE LOS APORTES AFRICANOS A LA FAMILIA ESCLAVISTA EN BRASIL

      Directory of Open Access Journals (Sweden)

      Christianne Silva Vasconcellos

      2011-01-01

      Full Text Available Este artículo presenta un análisis de la producción y el uso de fotografías de personas africanas y afrodescendientes, realizadas en Brasil entre 1840, cuando esta técnica fue introducida al país, y 1920, cuando las primeras fotografías aún estaban en circulación. Desde la evidencia visual, se analizan tres temas recurrentes en el Brasil del siglo XIX: la difusión de teorías del racismo científico europeo a través de la fotografía, la creación de los tipos urbanos en las ciudades esclavistas y las nodrizas (amas de leche como agentes culturales en el seno de la familia colonial en Bahía.

    5. Fotografías de amas de leche en bahía. Evidencia visual de los aportes Africanos a la familia esclavista en Brasil

      Directory of Open Access Journals (Sweden)

      Christianne Silva Vasconcellos

      2011-10-01

      Full Text Available Este artículo presenta un análisis de la producción y el uso de fotografías de personas africanas y afrodescendientes, realizadas en Brasil entre 1840, cuando esta técnica fue introducida al país, y 1920, cuando las primeras fotografías aún estaban en circulación. Desde la evidencia visual, se analizan tres temas recurrentes en el Brasil del siglo XIX: la difusión de teorías del racismo científico europeo a través de la fotografía, la creación de los tipos urbanos en las ciudades esclavistas y las nodrizas (amas de leche como agentes culturales en el seno de la familia colonial en Bahía.

    6. Impact on malaria parasite multiplication rates in infected volunteers of the protein-in-adjuvant vaccine AMA1-C1/Alhydrogel+CPG 7909.

      Directory of Open Access Journals (Sweden)

      Christopher J A Duncan

      Full Text Available BACKGROUND: Inhibition of parasite growth is a major objective of blood-stage malaria vaccines. The in vitro assay of parasite growth inhibitory activity (GIA is widely used as a surrogate marker for malaria vaccine efficacy in the down-selection of candidate blood-stage vaccines. Here we report the first study to examine the relationship between in vivo Plasmodium falciparum growth rates and in vitro GIA in humans experimentally infected with blood-stage malaria. METHODS: In this phase I/IIa open-label clinical trial five healthy malaria-naive volunteers were immunised with AMA1/C1-Alhydrogel+CPG 7909, and together with three unvaccinated controls were challenged by intravenous inoculation of P. falciparum infected erythrocytes. RESULTS: A significant correlation was observed between parasite multiplication rate in 48 hours (PMR and both vaccine-induced growth-inhibitory activity (Pearson r = -0.93 [95% CI: -1.0, -0.27] P = 0.02 and AMA1 antibody titres in the vaccine group (Pearson r = -0.93 [95% CI: -0.99, -0.25] P = 0.02. However immunisation failed to reduce overall mean PMR in the vaccine group in comparison to the controls (vaccinee 16 fold [95% CI: 12, 22], control 17 fold [CI: 0, 65] P = 0.70. Therefore no impact on pre-patent period was observed (vaccine group median 8.5 days [range 7.5-9], control group median 9 days [range 7-9]. CONCLUSIONS: Despite the first observation in human experimental malaria infection of a significant association between vaccine-induced in vitro growth inhibitory activity and in vivo parasite multiplication rate, this did not translate into any observable clinically relevant vaccine effect in this small group of volunteers. TRIAL REGISTRATION: ClinicalTrials.gov [NCT00984763].

    7. Virosome-formulated Plasmodium falciparum AMA-1 & CSP derived peptides as malaria vaccine: randomized phase 1b trial in semi-immune adults & children.

      Directory of Open Access Journals (Sweden)

      Patrick Georges Cech

      Full Text Available BACKGROUND: This trial was conducted to evaluate the safety and immunogenicity of two virosome formulated malaria peptidomimetics derived from Plasmodium falciparum AMA-1 and CSP in malaria semi-immune adults and children. METHODS: The design was a prospective randomized, double-blind, controlled, age-deescalating study with two immunizations. 10 adults and 40 children (aged 5-9 years living in a malaria endemic area were immunized with PEV3B or virosomal influenza vaccine Inflexal®V on day 0 and 90. RESULTS: No serious or severe adverse events (AEs related to the vaccines were observed. The only local solicited AE reported was pain at injection site, which affected more children in the Inflexal®V group compared to the PEV3B group (p = 0.014. In the PEV3B group, IgG ELISA endpoint titers specific for the AMA-1 and CSP peptide antigens were significantly higher for most time points compared to the Inflexal®V control group. Across all time points after first immunization the average ratio of endpoint titers to baseline values in PEV3B subjects ranged from 4 to 15 in adults and from 4 to 66 in children. As an exploratory outcome, we found that the incidence rate of clinical malaria episodes in children vaccinees was half the rate of the control children between study days 30 and 365 (0.0035 episodes per day at risk for PEV3B vs. 0.0069 for Inflexal®V; RR  = 0.50 [95%-CI: 0.29-0.88], p = 0.02. CONCLUSION: These findings provide a strong basis for the further development of multivalent virosomal malaria peptide vaccines. TRIAL REGISTRATION: ClinicalTrials.gov NCT00513669.

    8. Safe and Efficacious Use of Automated Bolus Advisors in Individuals Treated With Multiple Daily Insulin Injection (MDI) Therapy: Lessons Learned From the Automated Bolus Advisor Control and Usability Study (ABACUS).

      Science.gov (United States)

      Parkin, Christopher G; Barnard, Katharine; Hinnen, Deborah A

      2015-03-20

      Numerous studies have shown that use of integrated automated bolus advisors (BAs) provides significant benefits to individuals using insulin pump devices, including improved glycemic control and greater treatment satisfaction. Within the past few years, BA devices have been developed specifically for individuals treated with multiple daily insulin injection (MDI) therapy; however, many clinicians who treat these individuals may be unfamiliar with insulin pump therapy and, thus, BA use. Findings from the Automated Bolus Advisor Control and Usability Study (ABACUS) revealed that BA use can be efficacious and clinically meaningful in MDI therapy, and that most patients are willing and able to use this technology appropriately when adequate clinical support is provided. The purpose of this article is to review key learnings from ABACUS and provide practical advice for initiating BA use and monitoring therapy.

    9. Utilizing Robot Operating System (ROS) in Robot Vision and Control

      Science.gov (United States)

      2015-09-01

      OPERATING SYSTEM (ROS) IN ROBOT VISION AND CONTROL by Joshua S. Lum September 2015 Thesis Advisor: Xiaoping Yun Co-Advisor: Zac Staples...Master’s Thesis 4. TITLE AND SUBTITLE UTILIZING ROBOT OPERATING SYSTEM (ROS) IN ROBOT VISION AND CONTROL 5. FUNDING NUMBERS 6. AUTHOR(S) Lum, Joshua S...DISTRIBUTION CODE 13. ABSTRACT (maximum 200 words) The Robot Operating System (ROS) is an open-source framework that allows robot developers to create

    10. The challenges of science journalism: The perspectives of scientists, science communication advisors and journalists from New Zealand.

      Science.gov (United States)

      Ashwell, Douglas James

      2016-04-01

      The news media play an important role in informing the public about scientific and technological developments. Some argue that restructuring and downsizing result in journalists coming under increased pressure to produce copy, leading them to use more public relations material to meet their deadlines. This article explores science journalism in the highly commercialised media market of New Zealand. Using semi-structured interviews with scientists, science communication advisors and journalists, the study finds communication advisors and scientists believe most media outlets, excluding public service media, report science poorly. Furthermore, restructuring and staff cuts have placed the journalists interviewed under increasing pressure. While smaller newspapers appear to be printing press releases verbatim, metropolitan newspaper journalists still exercise control over their use of such material. The results suggest these journalists will continue to resist increasing their use of public relations material for some time to come. © The Author(s) 2014.

    11. Career advising in family medicine: a theoretical framework for structuring the medical student/faculty advisor interview

      Directory of Open Access Journals (Sweden)

      Melissa Bradner

      2013-08-01

      Full Text Available Background: There are unique challenges to recruiting students into the specialty of family medicine within academic medical centers. Methods: At Virginia Commonwealth University, we developed an advising framework to help students address institutional and personal obstacles to choosing family medicine as a career. Results: The role of a faculty advisor is not to direct the student to a career choice but rather to foster a mentor relationship and help the student come to his or her own realizations regarding career choice. The faculty advisor/medical student interview is conceptualized as five discussion topics: self-knowledge, perception, organizational voice, cognitive dissonance, and anticipatory counseling. Conclusion: This framework is intended to assist faculty in their efforts to encourage students to consider a career in family medicine.

    12. The role and functions of the physical science subject advisor in the North West Province / Kebogile Elizabeth Dilotsotlhe

      OpenAIRE

      Dilotsotlhe, Kebogile Elizabeth

      1999-01-01

      The aim of this study was to investigate the ,role and functions of the physical science subject advisors in the North West Province. In order to establish these, a historical study of their role and functions has been undertaken in the following chapters through a literature survey. In chapter 1, the rationale for the study, research strategy and empirical research strategy is presented. A brief study of the history of the inspectorate/advisory service in South Africa, the Uni...

    13. Cross-Cultural Strategies for Improving the Teaching, Training, and Mentoring Skills of Military Transition Team Advisors

      Science.gov (United States)

      2010-04-01

      host nationals, many advisors were able to accomplish very little (Ramsden-Zbylut, Metcalf, McGowan, Beemer, Vowels , & Brunner, 2008...Hofstede, 1980, 2001). People in individualistic societies are characterized by an emotional independence from “groups, organizations, and/or...the “intuitive-affective style of emotional appeal” (Glenn, Witmeyer, & Stevenson, 1977) is key to the manner in which ideas are organized and

    14. Does young adults' preferred role in decision making about health, money, and career depend on their advisors' leadership skills?

      Science.gov (United States)

      Garcia-Retamero, Rocio; Galesic, Mirta

      2013-01-01

      Few empirical data exist on how decision making about health differs from that in other crucial life domains with less threatening consequences. To shed light on this issue we conducted a study with 175 young adults (average age 19 years). We presented the participants with scenarios involving advisors who provided assistance in making decisions about health, money, and career. For each scenario, participants were asked to what extent they wanted the advisor to exhibit several leadership styles and competencies and what role (active, collaborative, or passive) they preferred to play when making decisions. Results show that decision making about health is distinct from that in the other domains in three ways. First, most of the participants preferred to delegate decision making about their health to their physician, whereas they were willing to collaborate or play an active role in decision making about their career or money. Second, the competencies and leadership style preferred for the physician differed substantially from those desired for advisors in the other two domains: Participants expected physicians to show more transformational leadership--the style that is most effective in a wide range of environments--than those who provide advice about financial investments or career. Finally, participants' willingness to share medical decision making with their physician was tied to how strongly they preferred that the physician shows an effective leadership style. In contrast, motivation to participate in decision making in the other domains was not related to preferences regarding advisors' leadership style or competencies. Our results have implications for medical practice as they suggest that physicians are expected to have superior leadership skills compared to those who provide assistance in other important areas of life.

    15. Doctoral Advisor-Advisee Pairing in STEM Fields: Selection Criteria and Impact of Faculty, Student and Departmental Factors

      Directory of Open Access Journals (Sweden)

      Simy Joy

      2015-09-01

      Full Text Available Unlike the doctoral programs in places where students are paired with advisors at the time of admission itself, most US programs require the students to choose their advisors, and the advisors to formally accept the students as advisees. Little research has been done to understand how students and faculty approach this mutual selection and pairing process. This paper examines this process in STEM departments (Science, Technology, Engineering and Mathematics, with specific focus on factors influencing the decisions. Based on focus groups and interviews of doctoral students and faculty from STEM departments in an American university, we identify criteria applied by students and faculty in making their choices. Students were found to assess faculty on available funding, area of research, personality, ability to graduate students fast, and career prospects for students, and faculty to assess students on their qualifications/credentials and perceived ability to contribute to research. We also found that this mutual assessment was not objective, but influenced by perceptions associated with faculty gender and career stage, and student nationality. In the end, whether students and faculty were actually paired with persons of their choice depended on departmental factors including prevalent pairing practices, restrictions on student numbers per faculty, and reward structure. We discuss implications of the findings for research and practice.

    16. Designing a Community-Based Lay Health Advisor Training Curriculum to Address Cancer Health Disparities

      Science.gov (United States)

      Gwede, Clement K.; Ashley, Atalie A.; McGinnis, Kara; Montiel-Ishino, F. Alejandro; Standifer, Maisha; Baldwin, Julie; Williams, Coni; Sneed, Kevin B.; Wathington, Deanna; Dash-Pitts, Lolita; Green, B. Lee

      2012-01-01

      Introduction Racial and ethnic minorities have disproportionately higher cancer incidence and mortality than their White counterparts. In response to this inequity in cancer prevention and care, community-based lay health advisors (LHAs) may be suited to deliver effective, culturally relevant, quality cancer education, prevention/screening, and early detection services for underserved populations. Approach and Strategies Consistent with key tenets of community-based participatory research (CBPR), this project engaged community partners to develop and implement a unique LHA training curriculum to address cancer health disparities among medically underserved communities in a tricounty area. Seven phases of curriculum development went into designing a final seven-module LHA curriculum. In keeping with principles of CBPR and community engagement, academic–community partners and LHAs themselves were involved at all phases to ensure the needs of academic and community partners were mutually addressed in development and implementation of the LHA program. Discussion and Conclusions Community-based LHA programs for outreach, education, and promotion of cancer screening and early detection, are ideal for addressing cancer health disparities in access and quality care. When community-based LHAs are appropriately recruited, trained, and located in communities, they provide unique opportunities to link, bridge, and facilitate quality cancer education, services, and research. PMID:22982709

    17. Investigating the effect of in-service training on advisors' effectiveness through psychological empowerment

      Directory of Open Access Journals (Sweden)

      Farideh Dokaneheeifard

      2015-05-01

      Full Text Available Efficiency is one of the fundamental concepts in any organization including ministry of education of Iran. Teachers and counselors are the main assets of this organization and education plays a key role in achieving the organization's goals. In-service training is a technique for improving the quality and effectiveness of the advisors. This paper presents a study on the effect of in-service training on advisors’ effectiveness through psychological empowerment. The study uses a questionnaire developed by Spreitzer (1995 [Spreitzer, G. M. (1995. Psychological empowerment in the workplace: Dimensions, measurement, and validation. Academy of management Journal, 38(5, 1442-1465.] to examine the effects of five variables; namely self- efficacy, self-determination, impact, meaningfulness and trust. Using structural equation modeling, the study has determined that all five psychological empowerment components had positive and meaningful effects on in-service training. In addition, in-service training maintained positive and meaningful impacts on all components on psychological empowerment. Moreover, in-service training positively influenced on psychological empowerment.

    18. A survey of biosecurity-related practices, opinions and communications across dairy farm veterinarians and advisors.

      Science.gov (United States)

      Sayers, R G; Good, M; Sayers, G P

      2014-05-01

      Biosecurity at farm-level can often be poorly implemented, and lack of information has been cited by many studies as a potential explanation. Veterinary practitioners (VPs) and dairy advisors (DAs) play a central role in the provision of animal health and management services to dairy farmers. The objective of this study was to document and compare biosecurity-related practices and opinions across VPs and DAs in Ireland. A selection of veterinary experts (VEs) from outside of Ireland was also surveyed. Questionnaires were completed and response rates of 47% (VPs), 97% (DAs), and 65% (VEs) were achieved. Significant differences were identified in the promotion and implementation of biosecurity between VPs and DAs, with a higher proportion of VPs regularly receiving requests from (P = 0.004), and dispensing advice to (P biosecurity implementation, the majority of VPs (62%) prioritised external factors such as 'economic benefit' and 'mandatory obligation', while the majority of DAs prioritised health/animal-related factors (69%), which were similar to those of farmers (83.1%), although they remained significantly less likely (OR = 1.8) than farmers to choose such motivators (P = 0.005). Inconsistencies in the implementation of, and in opinions relating to, farm biosecurity were highlighted across all the groups surveyed emphasising the need for standardised information and improved communication.

    19. Facebook Use between College Resident Advisors' and Their Residents: A Mixed Methods Approach.

      Science.gov (United States)

      Kacvinsky, Lauren E; Moreno, Megan A

      2014-01-01

      Facebook use is nearly ubiquitous among college students. Studies have shown links between Facebook displays of depression or problem drinking and risk of these problems. This project aimed to determine whether Facebook could be used to help Resident Advisors (RAs) identify college students at risk for depression or problem drinking. Interviews were conducted with college freshmen to investigate whether they were Facebook "friends" with their RA. Focus groups were conducted with RAs to determine their views on Facebook friending their dormitory residents and using Facebook to help identify at-risk students. 72 freshmen were interviewed and 25 RAs participated in focus groups; both agreed it is common for RAs and residents to be Facebook friends. RAs commonly noted references to depression and problem drinking on residents' Facebook pages, which often led to in-person discussions with the resident. This study provides support that RAs use Facebook to identify issues that may impact their student residents. RAs emphasized benefits of in-person interactions in order to provide support and obtain additional details about the situation. Universities could consider whether providing RA education about Facebook interactions with residents merits encouragement within their existing RA training programs.

    20. An insight into the emerging role of regional medical advisor in the pharmaceutical industry

      Directory of Open Access Journals (Sweden)

      Sandeep Kumar Gupta

      2013-01-01

      Full Text Available The position of regional medical advisor (RMA is relatively new in the pharmaceutical industry and its roles and responsibility are still evolving. The RMA is a field based position whose main mission is to foster collaborative relationships with the key opinion leaders (KOLs and to facilitate the exchange of unbiased scientific information between the medical community and the company. Field-based medical liaison teams are expanding world-wide as part of the pharmaceutical industry′s increased focus on global operations including emerging markets. Now, the position of the RMA has evolved into comprehensive, complex, highly interactive, targeted, highly strategic, innovative, and independent role since its inception by the Upjohn Company in 1967. The major objective of the RMA is to develop the professional relationships with the health-care community, particularly KOLs, through peer-to-peer contact. The RMA can facilitate investigator-initiated clinical research proposals from approval until completion, presentation, and publication. It is possible for a RMA to have valuable access to KOLs through his expertise in the clinical research. The RMA can assist in the development, review, and follow-up of the clinical studies initiated within the relevant therapeutic area at the regional/local level. The RMA can lead regional/local clinical projects to ensure that all clinical trials are conducted in compliance with the International Conference of Harmonisation Good Clinical Practice (ICH GCP guidelines.

    1. Building Rapport Between International Graduate Students and Their Faculty Advisors: Cross-Cultural Mentoring Relationships at the University of Guelph

      Directory of Open Access Journals (Sweden)

      Faiza Omar

      2016-12-01

      Full Text Available Mentoring graduate students is very challenging, even when both the student and faculty have similar cultural values. Many international students have a different culture from that of Canadian. Their challenge is adapting to their new environment, and for their faculty advisors to understand and work well with them. This research explored the relationships, experience, and challenges of international graduate students and their faculty advisors at the University of Guelph, through focus group discussions, semi-structured face-to-face interviews and online surveys. Language barriers and financial difficulties were among the major challenges international students face adapting to their academic and social environment and working with their faculty advisors. We found that building good student-advisor relationship requires understanding graduate student and advisor formal responsibilities and expectations. Le mentorat des étudiants de cycles supérieurs pose tout un défi, même dans les cas où l’étudiant et le professeur ont tous deux des valeurs culturelles semblables. De nombreux étudiants internationaux viennent d’une culture différente de ce que nous connaissons au Canada. Leur défi est de s’adapter à leur nouvel environnement et pour leurs conseillers pédagogiques, de les comprendre et de collaborer avec eux. Cette recherche explore les relations de travail, l’expérience et les défis auxquels sont confrontés les étudiants internationaux de cycles supérieurs et leurs conseillers pédagogiques à l’Université de Guelph par le biais de discussions de groupes de consultation, d’entrevues face à face semi-structurées et d’un sondage en ligne. Les barrières linguistiques et les difficultés financières s’avèrent comme étant les défis principaux auxquels font face les étudiants internationaux lors de leur adaptation à leur environnement académique et social et dans leurs interactions avec leurs conseillers p

    2. Linear Optimization of Frequency Spectrum Assignments Across System

      Science.gov (United States)

      2016-03-01

      Instead of separate transmit and receive apertures for each of the multiple radar , communications, and electronic warfare systems, a few pairs of AMRF-C... OPTIMIZATION OF FREQUENCY SPECTRUM ASSIGNMENTS ACROSS SYSTEMS by Steven J. Fischbach March 2016 Thesis Advisor: Jeffrey Hyink Thesis Co-Advisor...March 2016 3. REPORT TYPE AND DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE LINEAR OPTIMIZATION OF FREQUENCY SPECTRUM ASSIGNMENTS ACROSS

    3. İslam Hukuku açısından yaşama hakkı ve ötanazi

      OpenAIRE

      ÇELİK, Alime

      2016-01-01

      Tezde ötanazi, yaşama hakkı bağlamında ele alınmıştır. Ötanazinin tanımı ve kapsamı belirtildikten sonra çeşitleri ile birlikte detaylıca bilgi verilmiştir. Ötanazi hakkındaki tartışmalara yer verilmiştir. Ötanaziyi destekleyen ve reddeden görüşlerden bahsedilmiştir. Ötanazinin İslâm Hukuku açısından sonuçlarına yer verilmiştir. Başlıca ötanazi çeşitlerinin değerlendirilmesi yapılmıştır. Tez giriş ve iki bölümden oluşmaktadır. Giriş kısmında, tezin içeriği ve hazırlan...

    4. A Phase 1 study of the blood-stage malaria vaccine candidate AMA1-C1/Alhydrogel with CPG 7909, using two different formulations and dosing intervals.

      Science.gov (United States)

      Ellis, Ruth D; Mullen, Gregory E D; Pierce, Mark; Martin, Laura B; Miura, Kazutoyo; Fay, Michael P; Long, Carole A; Shaffer, Donna; Saul, Allan; Miller, Louis H; Durbin, Anna P

      2009-06-24

      A Phase 1 study was conducted in 24 malaria naïve adults to assess the safety and immunogenicity of the recombinant protein vaccine apical membrane antigen 1-Combination 1 (AMA1-C1)/Alhydrogel with CPG 7909 in two different formulations (phosphate buffer and saline), and given at two different dosing schedules, 0 and 1 month or 0 and 2 months. Both formulations were well tolerated and frequency of local reactions and solicited adverse events was similar among the groups. Peak antibody levels in the groups receiving CPG 7909 in saline were not significantly different than those receiving CPG 7909 in phosphate. Peak antibody levels in the groups vaccinated at a 0,2 month interval were 2.52-fold higher than those vaccinated at a 0,1 month interval (p=0.037, 95% CI 1.03, 4.28). In vitro growth inhibition followed the antibody level: median inhibition was 51% (0,1 month interval) versus 85% (0,2 month interval) in antibody from samples taken 2 weeks post-second vaccination (p=0.056).

    5. The recovery boiler advisor. Combination of practical experience and advanced thermodynamic modelling

      Energy Technology Data Exchange (ETDEWEB)

      Backman, R. [Aabo Akademi, Turku (Finland); Eriksson, G. [LTH/RWTH (Germany); Sundstroem, K. [Tampella Power Oy, Tampere (Finland)

      1996-12-31

      The Aabo Advisor is a computer based program intended to provide information about the high temperature ash and fluegas chemistry in pulping spent black liquor recovery boilers of kraft pulp mills. The program can be used for predictions of a variety of furnace and flue gas phenomena, such as fireside fouling of the heat exchanger surfaces caused by the flue gas particulate matter, emissions of SO{sub 2}(g), HCl(g) and NO{sub x}(g) with the flue gas etc. The program determines the composition of the fluegas as well as the amount and composition of the two typical fly ash fractions found in recovery boiler fluegases, the condensed fly ash particles and the carry over particles. These data are used for calculating the melting behavior of the fly ash present at different locations in the boiler and this characteristic behavior is used for the fireside fouling predictions. The program may also be used for studying how different mill processes affecting the black liquor composition affects on the fireside chemistry of the recovery boiler. As input data for the calculations only a few boiler operation parameters and the composition of the black liquor is required. The calculations are based on a one-dimensional, multi-stage chemistry model where both thermodynamic equilibrium calculations and stoichiometric material balances are used. The model calculates at first the chemistry in the lower furnace and smelt after which it moves to the upper furnace and the radiative parts of the fluegas channel. As the last block the program calculates the chemistry in the convective part, the electrostatic precipitator cath and stack. The results from each block are presented in tables, key numbers and melt curves representing the fluegas or fly ash fraction present at each location

    6. Detecting the Online Image of “Average” Restaurants on TripAdvisor

      Directory of Open Access Journals (Sweden)

      Hrvoje Jakopović

      2016-06-01

      Full Text Available Collective intelligence can be interpreted as the actions of individuals that provide collective effects. In online spaces, the more user comments about a matter of discussion, the higher the potential that certain repeated points of view will be used as a story frame. This observation can be a very useful explanation for the value of user comments, reviews and the ratings in the field of public relations. Nowadays, it has become noticeable that many indecisive people who are thinking of buying a product or using a certain service rely on information left by users who already have some kind of experience with the product or service. This information has an effect on decision-making and taking action. In the case of contemporary PR, collective intelligence, facilitated through user comments/reviews, is involved in the image making process. This paper uses the idea of collective intelligence to measure restaurants’ online image, using sentiment analysis to gain insight to users’ attitudes and opinions. Image is interpreted as a short-term outcome of organizational activities that can be identified through individual attitudes and opinions in this study. The author uses sentiment analysis, the use of natural language processing applications, to examine user comments and reviews for restaurants in Dubrovnik rated as “average” on the website TripAdvisor. This paper tests the accuracy of sentiment analysis software, therefore the efficiency of automated sentiment analysis is compared to human sentiment analysis. The results indicate that sentiment analysis tools could be important instruments for the estimation of a positive, negative, or neutral sentiment and detection of organization’s online image.

    7. The Development of the Multi-Center Traffic Management Advisor (MCTMA): Traffic Flow Management Research in a Multi-Facility Environment

      Science.gov (United States)

      Lee, Katharine K.; Davis, Thomas J.; Levin, Kerry M.; Rowe, Dennis W.

      2001-01-01

      The Traffic Management Advisor (TMA) is a decision-support tool for traffic managers and air traffic controllers that provides traffic flow visualization and other flow management tools. TMA creates an efficiently sequenced and safely spaced schedule for arrival traffic that meets but does not exceed specified airspace system constraints. TMA is being deployed at selected facilities throughout the National Airspace System in the US as part of the FAA's Free Flight Phase 1 program. TMA development and testing, and its current deployment, focuses on managing the arrival capacity for single major airports within single terminal areas and single en route centers. The next phase of development for this technology is the expansion of the TMA capability to complex facilities in which a terminal area or airport is fed by multiple en route centers, thus creating a multicenter TMA functionality. The focus of the multi-center TMA (McTMA) development is on the busy facilities in the Northeast comdor of the US. This paper describes the planning and development of McTMA and the challenges associated with adapting a successful traffic flow management tool for a very complex airspace.

    8. Design and Analysis of a Solar-Powered Compressed Air Energy Storage System

      Science.gov (United States)

      2016-12-01

      ANALYSIS OF A SOLAR-POWERED COMPRESSED AIR ENERGY STORAGE SYSTEM by Thomas H. Prinsen December 2016 Thesis Advisor: Anthony Gannon Co-Advisor...TYPE AND DATES COVERED Master’s thesis 4. TITLE AND SUBTITLE DESIGN AND ANALYSIS OF A SOLAR-POWERED COMPRESSED AIR ENERGY STORAGE SYSTEM 5...a two-party study that analyzed a compressed air storage system using fundamental thermodynamic principles and designed the compression phase using

    9. Effectiveness of the United States Marine Corps Tiered Evaluation System

      Science.gov (United States)

      2015-03-01

      effectiveness. 14. SUBJECT TERl’\\IS Tiered Evaluation System, First Tenn Alignment Program, Quality, Retention 15. NUMBER OF PAGES 17. SECURITY...Crider Approved by: Jeremy A. Arkes Thesis Advisor Chad W. Seagren Co-Advisor William Gates Dean, Graduate School of Business...Lastly, first- tenn Marine re-enlistees must possess a high school diploma or altemate credential (Headquatiers, United States Marine C01ps, 2010

    10. TripAdvisor's what to do in...forums. How to exchange opinions and advise through interpersonality

      OpenAIRE

      Suau Jiménez, Francisca

      2013-01-01

      Esta comunicación se propone mostrar el análisis realizado desde el punto de vista del metadiscurso interpersonal en un corpus del género de internet Traveler Forums (Foros de Viajeros), extraidos del portal TripAdvisor en 2012. Es parte del proyecto de I+D sobre géneros del turismo del corpus COMETVAL (IULMA, Universitat de València), en inglés. En el foro de viajeros, autor y lector intercambian los roles con objeto de expresar opiniones y proporcionar información fiable y genuina. La metod...

    11. Advisor-advisee relationship: the multiplier knowledge Relação orientador-orientando: o conhecimento multiplicador

      Directory of Open Access Journals (Sweden)

      Lydia Masako Ferreira

      2009-06-01

      Full Text Available The article captures the essence of the advisor-advisee relationship as the fulcrum of the graduate program, and its influence and implications in the present formation process of new researchers.O artigo resgata a essência da relação orientador-orientado como núcleo de sustentação de um programa de pós-graduação senso estrito e suas influências e implicações no processo atual de formação dos pesquisadores.

    12. Beyond fragmentation and disconnect: Networks for knowledge exchange in the English land management advisory system

      NARCIS (Netherlands)

      Klerkx, L.W.A.; Proctor, A.

      2013-01-01

      The growing multifunctionality in agriculture, combined with privatisation of previously public agricultural extension services, has resulted in a pluralistic land management advisory system. Despite benefits in terms of increased client orientation and greater advisor diversity, it is argued that t

    13. Beyond fragmentation and disconnect: networks for knowledge sharing in the English land management advisory system

      NARCIS (Netherlands)

      Klerkx, L.W.A.; Proctor, A.

      2012-01-01

      The growing multifunctionality in agriculture, combined with privatisation of previously state-funded agricultural extension services, has resulted in a pluralistic land management advisory system. Despite benefits in terms of increased client orientation and greater advisor diversity, it is argued

    14. The Effects of the Uncertainty of Departures on Multi-Center Traffic Management Advisor (TMA) Scheduling

      Science.gov (United States)

      Thipphavong, Jane; Landry, Steven J.

      2005-01-01

      The Multi-center Traffic Management Advisor (McTMA) provides a platform for regional or national traffic flow management, by allowing long-range cooperative time-based metering to constrained resources, such as airports or air traffic control center boundaries. Part of the demand for resources is made up of proposed departures, whose actual departure time is difficult to predict. For this reason, McTMA does not schedule the departures in advance, but rather relies on traffic managers to input their requested departure time. Because this happens only a short while before the aircraft's actual departure, McTMA is unable to accurately predict the amount of delay airborne aircraft will need to take in order to accommodate the departures. The proportion of demand which is made up by such proposed departures increases as the horizon over which metering occurs gets larger. This study provides an initial analysis of the severity of this problem in a 400-500 nautical mile metering horizon and discusses potential solutions to accommodate these departures. The challenge is to smoothly incorporate departures with the airborne stream while not excessively delaying the departures.' In particular, three solutions are reviewed: (1) scheduling the departures at their proposed departure time; (2) not scheduling the departures in advance; and (3) scheduling the departures at some time in the future based on an estimated error in their proposed time. The first solution is to have McTMA to automatically schedule the departures at their proposed departure times. Since the proposed departure times are indicated in their flight times in advance, this method is the simplest, but studies have shown that these proposed times are often incorrect2 The second option is the current practice, which avoids these inaccuracies by only scheduling aircraft when a confirmed prediction of departure time is obtained from the tower of the departure airport. Lastly, McTMA can schedule the departures at a

    15. Between hope and evidence: how community advisors demarcate the boundary between legitimate and illegitimate stem cell treatments.

      Science.gov (United States)

      Petersen, Alan; Tanner, Claire; Munsie, Megan

      2015-03-01

      Stem cell science provides an exemplary study of the 'management of hope'. On the one hand, raising 'hopes' and expectations is a seen as a necessary aspect of securing investment in promising innovative research. On the other, such hyperbole risks raising hopes to a level that may lead people to undertake undue risks, which may ultimately undermine confidence in medical research. In this context, the 'management of hope' thus involves the negotiation of competing claims of truth about the value and safety of particular treatments and about the trustworthiness of providers. Using Gieryn's concept of boundary-work, this article examines the means by which this work of 'managing hope' is undertaken. Drawing on data collected as part of our study that investigated the perspectives of those who are consulted by patients and their carers about stem cell treatments, we explore how these community advisors – both scientists and clinicians with a stake in stem cell research and representatives from patient advocacy groups – demarcate the boundary between legitimate and illegitimate treatments. In particular, we examine how these actors rhetorically use 'evidence' to achieve this demarcation. We argue that analysing accounts of how advisors respond to patient enquiries about stem cell treatments offers a window for examining the workings of the politics of hope within contemporary bioscience and biomedicine. In conclusion, we emphasize the need to re-conceptualize the boundary between science and non-science so as to allow a better appreciation of the realities of health care in the age of medical travel.

    16. 同感技术在高校辅导员工作中的运用%Empathy Helps College Advisors Do their Job Better

      Institute of Scientific and Technical Information of China (English)

      李玲; 雷光辉

      2015-01-01

      Empathy can help advisors to communicate with students ,parents and school administrators in a better way so the teacher-student relationship and the family -school relationship will be more harmonious .In using empathy ,advisors need to show sincerity and respect .%辅导员利用同感技术有助于促进与学生、家长、学校管理者的有效沟通,构建和谐的师生和家校关系,同时探讨了辅导员在使用同感技术时需要真诚与尊重。

    17. Automated bolus advisor control and usability study (ABACUS: does use of an insulin bolus advisor improve glycaemic control in patients failing multiple daily insulin injection (MDI therapy? [NCT01460446

      Directory of Open Access Journals (Sweden)

      Cavan David A

      2012-10-01

      Full Text Available Abstract Background People with T1DM and insulin-treated T2DM often do not follow and/or adjust their insulin regimens as needed. Key contributors to treatment non-adherence are fear of hypoglycaemia, difficulty and lack of self-efficacy associated with insulin dose determination. Because manual calculation of insulin boluses is both complex and time consuming, people may rely on empirical estimates, which can result in persistent hypoglycaemia and/or hyperglycaemia. Use of automated bolus advisors (BA has been shown to help insulin pump users to more accurately meet prandial insulin dosage requirements, improve postprandial glycaemic excursions, and achieve optimal glycaemic control with an increased time within optimal range. Use of a BA containing an early algorithm based on sliding scales for insulin dosing has also been shown to improve HbA1c levels in people treated with multiple daily insulin injections (MDI. We designed a study to determine if use of an automated BA can improve clinical and psychosocial outcomes in people treated with MDI. Methods/design The Automated Bolus Advisor Control and Usability Study (ABACUS is a 6-month, prospective, randomised, multi-centre, multi-national trial to determine if automated BA use improves glycaemic control as measured by a change in HbA1c in people using MDI with elevated HbA1c levels (#62;7.5%. A total of 226 T1DM and T2DM participants will be recruited. Anticipated attrition of 20% will yield a sample size of 90 participants, which will provide #62;80% power to detect a mean difference of 0.5%, with SD of 0.9%, using a one-sided 5% t-test, with 5% significance level. Other measures of glycaemic control, self-care behaviours and psychosocial issues will also be assessed. Discussion It is critical that healthcare providers utilise available technologies that both facilitate effective glucose management and address concerns about safety and lifestyle. Automated BAs may help people using MDI to

    18. Adenovirus-5-vectored P. falciparum vaccine expressing CSP and AMA1. Part B: safety, immunogenicity and protective efficacy of the CSP component.

      Directory of Open Access Journals (Sweden)

      Cindy Tamminga

      Full Text Available BACKGROUND: A protective malaria vaccine will likely need to elicit both cell-mediated and antibody responses. As adenovirus vaccine vectors induce both these responses in humans, a Phase 1/2a clinical trial was conducted to evaluate the efficacy of an adenovirus serotype 5-vectored malaria vaccine against sporozoite challenge. METHODOLOGY/PRINCIPAL FINDINGS: NMRC-MV-Ad-PfC is an adenovirus vector encoding the Plasmodium falciparum 3D7 circumsporozoite protein (CSP. It is one component of a two-component vaccine NMRC-M3V-Ad-PfCA consisting of one adenovector encoding CSP and one encoding apical membrane antigen-1 (AMA1 that was evaluated for safety and immunogenicity in an earlier study (see companion paper, Sedegah et al. Fourteen Ad5 seropositive or negative adults received two doses of NMRC-MV-Ad-PfC sixteen weeks apart, at 1 x 1010 particle units per dose. The vaccine was safe and well tolerated. All volunteers developed positive ELISpot responses by 28 days after the first immunization (geometric mean 272 spot forming cells/million[sfc/m] that declined during the following 16 weeks and increased after the second dose to levels that in most cases were less than the initial peak (geometric mean 119 sfc/m. CD8+ predominated over CD4+ responses, as in the first clinical trial. Antibody responses were poor and like ELISpot responses increased after the second immunization but did not exceed the initial peak. Pre-existing neutralizing antibodies (NAb to Ad5 did not affect the immunogenicity of the first dose, but the fold increase in NAb induced by the first dose was significantly associated with poorer antibody responses after the second dose, while ELISpot responses remained unaffected. When challenged by the bite of P. falciparum-infected mosquitoes, two of 11 volunteers showed a delay in the time to patency compared to infectivity controls, but no volunteers were sterilely protected. SIGNIFICANCE: The NMRC-MV-Ad-PfC vaccine expressing CSP was

    19. Measurement of anti-mitochondria M2 antibodies in 1039 patients with cryptogenic hepatitis%1039例隐源性肝炎患者AMA-M2抗体的筛查

      Institute of Scientific and Technical Information of China (English)

      张玮; 王磊; 王奕; 王俐琼; 杜慧慧; 李青梅

      2012-01-01

      Objective To investigate the presence of AMA -M2 antibodies in 1039 patients with cryptogenic hepatitis. Methods M2 antibodies were tested by ELISA. Results M2 antibodies were detected in 81 (7.9% )of the 1039 patients;Of the 81 cases,57 were female and 24 were male,and the mean age was 53.0 ± 14.8 year old,and 78 patients were diagnosed as PBC;The most common symptoms were fatigue (74.4%,58/78), jaundice (61.5%, 48/78 )and skin itching (37.2% ,29/78); Besides, 39 (50.0% ) patients were with ANA positive,and 14 (18.0%) with anti-SSA/Ro positive. Conclusion On the diagnosis of the disease,the detection of serum antimitochondrial autoantibodies (AMA) is an important indicator. The detection of AMA-M2 is important for early diagnosis of patients with PBC.%目的 在1039例隐源性肝炎患者中筛查AMA-M2抗体,对男性和女性的M2抗体滴度、M2抗体阳性患者和M2抗体阴性患者的免疫指标、PBC患者的临床表现等进行统计分析,以早期诊断PBC.方法 采用ELISA法检测M2抗体滴度.结果 在1039例隐源性肝炎患者中,81例(7.9%)M2抗体阳性,其中57例为女性,24例为男性,平均年龄53.0±14.8岁;在78例PBC患者中,乏力(74.4%,58/78)、黄疸(61.5%,48/78)和皮肤瘙痒(37.2%,29/78)多见;合并ANA阳性者39例(50.0%,39/78),合并抗-SSA/Ro抗体阳性14例(17.9%,14/78).结论 AMAs的检测是诊断原发性胆汁性肝硬化的重要指标,检测M2抗体有助于早期诊断PBC.

    20. How Is the Internship Going Anyways? An Action Research Approach to Understanding the Triad Relationship between Interns, Mentors, and Field Advisors

      Science.gov (United States)

      Wong, Arch Chee Keen

      2011-01-01

      This article describes a research project that looks at the relationship between mentors, interns, and field advisors on a theological internship programme by way of the theory and practice relationship as it relates to the university and field context. The work of Hans Georg Gadamer is used as a framework for understanding the interviews using…

    1. Doing Research Together: A Study on the Views of Advisors with Intellectual Disabilities and Non-Disabled Researchers Collaborating in Research

      Science.gov (United States)

      Puyalto, Carol; Pallisera, Maria; Fullana, Judit; Vilà, Montserrat

      2016-01-01

      Background: Despite an increase in inclusive studies in recent years, research on the views of the people with and without disabilities who have participated in these studies is scarce. The aim of this study was to explore the perceptions and views of advisors with intellectual disabilities and non-disabled researchers who collaborated together on…

    2. Dissertation Leadership Knowledge Transfer Using Sparsely Connected Networks with Bidirectional Edges: Case Study of Chester Hayden McCall Jr., His Dissertation Advisors, and His Students

      Science.gov (United States)

      Mallette, Leo A.

      2012-01-01

      There are many modes of information flow in the sciences: books, journals, conferences, research and development, acquisition of companies, co-workers, students, and professors in schools of higher learning. In the sciences, dissertation students learn from their dissertation advisor (or chairperson or mentor) and the other dissertation committee…

    3. Building a Harmonious Relationship between College Advisors and Students%试论高校辅导员与学生和谐关系的构建

      Institute of Scientific and Technical Information of China (English)

      张硕

      2014-01-01

      通过分析导致当前高校辅导员和学生关系异化的原因,认为过分疏远与过分亲近是二者关系异化的突出表现,对师生恋这一敏感问题进行了剖析,将其归类为“深度忽略师生双方角色差异的极端表现”,并分别从辅导员自身、学生及外界环境三个层面探讨了构建高校辅导员与学生和谐关系的可行性方法与举措。%This paper probes into the causes of alienation between college advisors and their students, pointing out that advisors should be neither too distant from their students nor too close to them.The article takes a close look at the sensitive issue of teacher student relations,defining it as extreme neglect of role differences and then discusses what is respectively expected of advisors,students and the external environment in building a harmonious relationship between college advisors and students.

    4. How Is the Internship Going Anyways? An Action Research Approach to Understanding the Triad Relationship between Interns, Mentors, and Field Advisors

      Science.gov (United States)

      Wong, Arch Chee Keen

      2011-01-01

      This article describes a research project that looks at the relationship between mentors, interns, and field advisors on a theological internship programme by way of the theory and practice relationship as it relates to the university and field context. The work of Hans Georg Gadamer is used as a framework for understanding the interviews using…

    5. An Examination of the Relationship between Advisor/Advisee Personality Similarity with Student Satisfaction and Grade Point Average in a Community College Setting

      Science.gov (United States)

      Davis, Arlene

      2010-01-01

      The success of a student within the academic environment is a result of interaction of various factors. This study was designed to consider how personality similarity between the advisor and advisee may enhance advising, student satisfaction, and grade point average effort. The study concentrated on the relationship of personality characteristics…

    6. Advancing Understanding of the Characteristics and Capacity of African American Women Who Serve as Lay Health Advisors in Community-Based Settings

      Science.gov (United States)

      Shelton, Rachel C.; Dunston, Sheba King; Leoce, Nicole; Jandorf, Lina; Thompson, Hayley S.; Erwin, Deborah O.

      2017-01-01

      Lay Health Advisor (LHA) programs hold tremendous promise for reducing health disparities and addressing social determinants of health in medically underserved communities, including African American populations. Very little is understood about the capacity of LHAs in these roles and the broader contributions they make to their communities. This…

    7. University First Year Advisors: A network approach for first year student transition and retention. A Practice Report.

      Directory of Open Access Journals (Sweden)

      Geraldine Box

      2012-03-01

      Full Text Available Focussing expressly on student support and retention, improving the first year experience has been addressed by Murdoch University through the implementation of a School discipline-specific network of professional First Year Advisors (FYAs. FYA initiatives, both broad-based and varied, have been developed in alignment with the changing needs of students as identified throughout the semesters. A combination of outreach telephone campaigns and face-to-face student support enables FYAs to conduct a "just in time" approach to positively increase student engagement, and ultimately, retention. With a bespoke database, FYAs and academic staff have been able to streamline the process of reporting students in need of support, and gather data relating to student retention. The FYA program is yet to be formally evaluated although initial feedback and student consultation is promising. This paper outlines the program's development, current initiatives and expected outcomes.  

    8. 基于 Advisor 的纯电动汽车动力参数匹配

      Institute of Scientific and Technical Information of China (English)

      刘新; 凌鹏

      2013-01-01

        文中分析了纯电动汽车动力装置参数的选择对纯电动汽车性能的影响,建立了纯电动汽车电动机和传动系的参数匹配数学模型,并结合某型号纯电动汽车设计实例,利用 Advisor 软件对整车进行了纯电动汽车动力系统的仿真计算。结果表明,所选定的动力系统参数能够满足纯电动汽车动力性的要求。

    9. The Role of Student-Advisor Interactions in Apprenticing Undergraduate Researchers into a Scientific Community of Practice

      Science.gov (United States)

      Thiry, Heather; Laursen, Sandra L.

      2011-12-01

      Among science educators, current interest in undergraduate research (UR) is influenced both by the traditional role of the research apprenticeship in scientists' preparation and by concerns about replacing the current scientific workforce. Recent research has begun to demonstrate the range of personal, professional, and intellectual benefits for STEM students from participating in UR, yet the processes by which student-advisor interactions contribute to these benefits are little understood. We employ situated learning theory (Lave and Wenger, Situated learning: legitimate peripheral participation, Cambridge University Press, Cambridge in 1991) to examine the role of student-advisor interactions in apprenticing undergraduate researchers, particularly in terms of acculturating students to the norms, values, and professional practice of science. This qualitative study examines interviews with a diverse sample of 73 undergraduate research students from two research-extensive institutions. From these interviews, we articulate a continuum of practices that research mentors employed in three domains to support undergraduate scientists-in-training: professional socialization, intellectual support, and personal/emotional support. The needs of novice students differed from those of experienced students in each of these areas. Novice students needed clear expectations, guidelines, and orientation to their specific research project, while experienced students needed broader socialization in adopting the traits, habits, and temperament of scientific researchers. Underrepresented minority students, and to a lesser extent, women, gained confidence from their interactions with their research mentors and broadened their future career and educational possibilities. Undergraduate research at research-extensive universities exemplifies a cycle of scientific learning and practice where undergraduate researchers are mentored by graduate students and postdoctoral researchers, who are

    10. High frequency analysis of a plate carrying a concentrated nonlinear spring-mass system

      Science.gov (United States)

      Culver, Dean; Dowell, Earl

      2016-09-01

      Examining the behavior of dynamical systems with many degrees of freedom undergoing random excitation at high frequency often requires substantial computation. These requirements are even more stringent for nonlinear systems. One approach for describing linear systems, Asymptotic Modal Analysis (AMA), has been extended to nonlinear systems in this paper. A prototypical system, namely a thin plate carrying a concentrated hardening cubic spring-mass, is explored. The study focuses on the response of three principal variables to random, frequency-bounded excitation: the displacement of the mounting location of the discrete spring-mass, the relative displacement of the discrete mass to this mounting location, and the absolute displacement of the discrete mass. The results indicate that extending AMA to nonlinear systems for input frequency bands containing a large number of modes is feasible. Several advantageous properties of nonlinear AMA are found, and an additional reduced frequency-domain modal method, Dominance-Reduced Classical Modal Analysis (DRCMA), is proposed that is intermediate in accuracy and the cost of computation between AMA and Classical Modal Analysis (CMA).

    11. Caracterización del síndrome de Burnout en amas de casa residentes en el barrio Rodrigo de Bastidas de la ciudad de Santa Marta, Colombia

      Directory of Open Access Journals (Sweden)

      Ubaldo Rodriguez de Avila

      2014-07-01

      Full Text Available El síndrome de Burnout en amas de casa puede afectar la salud y la calidad de vida de esta población; lo anterior puede generar patologías y disfunción familiar. En este artículo se presentan los resultados de una investigación cuyo objetivo fue identificar y describir la presencia del síndrome de Burnout en amas de casa. Igualmente se estableció la relación existente entre el nivel sociocultural, el estado civil y la edad con la aparición del Burnout en amas de casa residentes del barrio Rodrigo de Bastidas en la ciudad de Santa Marta. Este estudio se desarrolló, a partir de la aplicación a 203 amas de casa quienes fueron seleccionadas de forma aleatoria, del Cuestionario de Burnout para Amas de Casa y una ficha sociodemográfica y se compararon los resultados. Estos mostraron que el 11,3 % estaban afectadas por el síndrome. Las edades oscilaban entre los 41 y 60 años y ellas ejercían labores domésticas desde hacía 1 a 30 años. La mayoría estaba casada o en unión libre y mostraron mayor nivel de cansancio emocional; lo que puede atribuirse al doble papel desempeñado: madres y trabajadoras. Así mismo un grupo significativo pertenecía a familias nucleares o extensas; por lo tanto, estas podían experimentar mayores estresores familiares. Abstract Burnout Syndrome in housewives can affect the health and quality of life of this population; this can generate diseases and family dysfunction. This article presents the results of an investigation whose aim was to identify and describe the presence of the Burnout Syndrome in housewives. Also was established the relationship between the socio-cultural level, marital status and age with the appearance of the Burnout in housewives who sit in the neighborhood Rodrigo de Bastidas in the city of Santa Marta. This study developed, from the application to 203 housewives who were selected randomly, of Burnout questionnaire for housewives and one tab socio-demographic and the results were

    12. 75 FR 80034 - Privacy Act of 1974: Notice of Proposed Privacy Act System of Records Revision and Proposed New...

      Science.gov (United States)

      2010-12-21

      ...) and certain provisions of the Agricultural Marketing Act of 1946 (AMA). GIPSA's Federal Grain... meal, as well as other agricultural commodities. Records in this system may be disclosed as follows to...; ] DEPARTMENT OF AGRICULTURE Privacy Act of 1974: Notice of Proposed Privacy Act System of Records Revision...

    13. P. Gluckman Chief Science Advisor to the Prime Minister, New Zealand signing the Guest book with CERN Director-General R. Heuer and Head of International Relations R. Voss. Accompanied by A. Bell throughout.

      CERN Multimedia

      Anna Pantelia

      2013-01-01

      P. Gluckman Chief Science Advisor to the Prime Minister, New Zealand signing the Guest book with CERN Director-General R. Heuer and Head of International Relations R. Voss. Accompanied by A. Bell throughout.

    14. Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) representative H. Ikukawa visiting ATLAS experiment with Collaboration Spokesperson P. Jenni, KEK representative T. Kondo and Advisor to CERN DG J. Ellis on 15 May 2007.

      CERN Multimedia

      Maximilien Brice

      2007-01-01

      Japanese Ministry of Education, Culture, Sports, Science and Technology (MEXT) representative H. Ikukawa visiting ATLAS experiment with Collaboration Spokesperson P. Jenni, KEK representative T. Kondo and Advisor to CERN DG J. Ellis on 15 May 2007.

    15. National Science Foundation Assistant Director for Mathematics and Physical Sciences Tony Chan (USA) visiting LHCb experiment on 23rd May 2007 with Spokesperson T. Nakada, Advisor to CERN Director-General J. Ellis and I. Belyaev of Syracuse

      CERN Multimedia

      Maximilien Brice

      2007-01-01

      National Science Foundation Assistant Director for Mathematics and Physical Sciences Tony Chan (USA) visiting LHCb experiment on 23rd May 2007 with Spokesperson T. Nakada, Advisor to CERN Director-General J. Ellis and I. Belyaev of Syracuse

    16. Perceptions of pre-clerkship medical students and academic advisors about sleep deprivation and its relationship to academic performance: a cross-sectional perspective from Saudi Arabia

      OpenAIRE

      AlFakhri, Lama; Sarraj, Jumana; Kherallah, Shouq; Kuhail, Khulood; Obeidat, Akef; Abu-Zaid, Ahmed

      2015-01-01

      Background The medical student population is believed to be at an increased risk for sleep deprivation. Little is known about students’ perceptions towards sleep deprivation and its relationship to academic performance. The aim of study is to explore the perceptions of medical students and their academic advisors about sleep deprivation and its relationship to academic performance. Methods The study took place at Alfaisal University, College of Medicine, Riyadh, Saudi Arabia. An online, anony...

    17. Identification of the Discrepancies between Pharmacist and Patient Perception of the Pharmacist’s Role as an Advisor on Drug Therapy Based on Social Science Theory

      OpenAIRE

      大島, 新司; Senoo, Kazuhiko; 根岸, 彰生; 秋元, 勇人; 大原, 厚祐; 井上, 直子; 大嶋, 繁; 久津間, 信明; 從二, 和彦; 小林, 大介

      2016-01-01

      Article 25-2 of the Japanese Pharmacists’ Act was revised in June 2014, establishing the position of pharmacists as “advisors on the use of Pharmaceuticals.” Prior to the Act’s revision, we investigated the perceptions of patients and pharmacists about pharmacists’ roles using a social science methodology. We also examined current opinions and necessary factors for the future growth and development of pharmacists. This questionnaire survey was conducted using an internet method. Patients and ...

    18. Design Specifications for the Advanced Instructional Design Advisor (AIDA). Volume 1

      Science.gov (United States)

      1992-01-01

      The diverter valve is not! oasitioned provertv. Blocked Air Duct The hose from the compresor to the aircraft may be blocked or kinked. thus...overtemperature, overspeed, smoke/fumes, oil system, generator, hydraulic system, compressor stall , engine flameout (requires emergency procedures

    19. Latino sexual and gender identity minorities promoting sexual health within their social networks: Process evaluation findings from a lay health advisor intervention

      Science.gov (United States)

      Sun, Christina J.; García, Manuel; Mann, Lilli; Alonzo, Jorge; Eng, Eugenia; Rhodes, Scott D.

      2015-01-01

      The HOLA intervention was a lay health advisor intervention designed to reduce the disproportionate HIV burden borne by Latino sexual and gender identity minorities (gay, bisexual, and other men who have sex with men, and transgender persons) living in the United States. Process evaluation data were collected for over a year of intervention implementation from 11 trained Latino male and transgender lay health advisors (Navegantes) to document the activities each Navegante conducted to promote condom use and HIV testing among his or her 8 social network members enrolled in the study. Over 13 months, the Navegantes reported conducting 1,820 activities. The most common activity was condom distribution. Navegantes had extensive reach beyond their enrolled social network members, and they engaged in health promotion activities beyond social network members enrolled in the study. There were significant differences between the types of activities conducted by Navegantes depending on who was present. Results suggest that lay health advisor interventions reach large number of at-risk community members and may benefit populations disproportionately impacted by HIV. PMID:25416309

    20. Usability Evaluation of Spot and Runway Departure Advisor (SARDA) Concept in Dallas/Fort Worth Airport Tower Simulation

      Science.gov (United States)

      Hayashi, Miwa; Hoang, Ty; Jung, Yoon C.; Gupta, Gautam; Malik, Waqar; Dulchinos, Victoria

      2013-01-01

      Spot and Runway Departure Advisor (SARDA) is a proposed decision-support tool for air traffic control tower controllers for reducing taxi delay and optimizing the departure sequence. In the present study, the tool's usability was evaluated to ensure that its claimed performance benefits are not being realized at the cost of increasing the work burden on controllers. For the evaluation, workload ratings and questionnaire responses collected during a human-in-the-loop simulation experiment were analyzed to assess the SARDA advisories' effects on the controllers' ratings on cognitive resources (e.g., workload, spare attention) and satisfaction. The results showed that SARDA reduced the controllers' workload and increased their spare attention. It also made workload and attention levels less susceptible to the effects of increases in the traffic load. The questionnaire responses suggested that the controllers generally were satisfied with the ease of use of the tool and the objectives of the SARDA concept, but with some caution. To gain more trust from controllers, the the reasoning behind advisories may need to be made more transparent to them.

    1. Can Lay Community Advisors Improve the Clarity of Research Participant Recruitment Materials and Increase the Likelihood of Participation?

      Science.gov (United States)

      Bowers, Barbara; Jacobson, Nora; Krupp, Anna

      2017-02-01

      Despite decades of effort, lower income people and ethnic minorities continue to be underrepresented as participants in health research. A group of racially and ethnically diverse, lower income community members (Community Advisors on Research Design and Strategies: CARDS®) was trained to review study designs and procedures and provide recommendations to researchers for increasing participation and making research materials more understandable to members of underrepresented communities. In this mixed methods study, one participant group (n = 55) was shown research materials (recruitment documents and a consent form) developed by a research team and approved by the local IRB. A second group (n = 45) was shown the same materials after they had also been reviewed and revised by CARDS. Interviews, which included both fixed-response and open-ended questions, were used to assess reactions of participants in both groups to the materials, including their hypothetical willingness to volunteer for the research described. Group differences were examined using the Chi-square distribution test. Proportional difference effect sizes were estimated using arcsine transformation. The qualitative data were subjected to conventional content analysis. Participants in the group shown the recruitment materials revised by CARDS were more likely to say they understood the documents, more likely to ask for more information about the study, and more likely to say they would participate in the research. Results of content analysis suggested a four-phase sequential process for deciding whether to participate in the research. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

    2. A ama-de-leite e o bebê: reflexões em torno do apagamento de uma face The wet nurse and the baby: reflections about the erasure of a face

      Directory of Open Access Journals (Sweden)

      Marco Antonio Stancik

      2009-01-01

      Full Text Available O objetivo deste breve ensaio é analisar um retrato fotográfico datado do final do século XIX, onde figuram uma ama-de-leite e um bebê. Propõe-se que este é também um retrato das desigualdades e contradições presentes nas relações sociais estabelecidas na sociedade brasileira, a partir do qual é possível exemplificar o emprego de fontes fotográficas no trabalho do historiador.The objective of this short essay is to analyses a portrait of the late of XIXth century. The portrait presents a wet nurse and a baby. It is believed that the picture may show the inequality and contradictions of social relations in the Brazilian society, and exemplify the use of photographic sources in the historical researches.

    3. Design of a Two-level Adaptive Multi-Agent System for Malaria Vectors driven by an ontology

      Directory of Open Access Journals (Sweden)

      Etang Josiane

      2007-07-01

      Full Text Available Abstract Background The understanding of heterogeneities in disease transmission dynamics as far as malaria vectors are concerned is a big challenge. Many studies while tackling this problem don't find exact models to explain the malaria vectors propagation. Methods To solve the problem we define an Adaptive Multi-Agent System (AMAS which has the property to be elastic and is a two-level system as well. This AMAS is a dynamic system where the two levels are linked by an Ontology which allows it to function as a reduced system and as an extended system. In a primary level, the AMAS comprises organization agents and in a secondary level, it is constituted of analysis agents. Its entry point, a User Interface Agent, can reproduce itself because it is given a minimum of background knowledge and it learns appropriate "behavior" from the user in the presence of ambiguous queries and from other agents of the AMAS in other situations. Results Some of the outputs of our system present a series of tables, diagrams showing some factors like Entomological parameters of malaria transmission, Percentages of malaria transmission per malaria vectors, Entomological inoculation rate. Many others parameters can be produced by the system depending on the inputted data. Conclusion Our approach is an intelligent one which differs from statistical approaches that are sometimes used in the field. This intelligent approach aligns itself with the distributed artificial intelligence. In terms of fight against malaria disease our system offers opportunities of reducing efforts of human resources who are not obliged to cover the entire territory while conducting surveys. Secondly the AMAS can determine the presence or the absence of malaria vectors even when specific data have not been collected in the geographical area. In the difference of a statistical technique, in our case the projection of the results in the field can sometimes appeared to be more general.

    4. A Plasmodium vivax plasmid DNA- and adenovirus-vectored malaria vaccine encoding blood stage antigens AMA1 and MSP142 in a prime/boost heterologous immunization regimen partially protects Aotus monkeys against blood stage challenge.

      Science.gov (United States)

      Obaldia, Nicanor; Stockelman, Michael G; Otero, William; Cockrill, Jennifer A; Ganeshan, Harini; Abot, Esteban N; Zhang, Jianfeng; Limbach, Keith; Charoenvit, Yupin; Doolan, Denise L; Tang, De-Chu C; Richie, Thomas L

      2017-02-08

      Malaria is caused by parasites of the genus Plasmodium that are transmitted to humans by the bites of Anopheles mosquitoes. After the elimination of P. falciparum it is predicted that Plasmodium vivax will remain an important cause of morbidity and mortality outside of Africa, stressing the importance of developing a vaccine against malaria. In this study we assess the immunogenicity and protective efficacy of two P. vivax antigens, AMA1 and MSP142 in a recombinant DNA plasmid prime/adenoviral vector (Ad) boost regimen in Aotus monkeys. Groups of 4 to 5 monkeys were immunized with DNA alone, Ad alone, prime/boost regimens of each antigen, prime/boost with both antigens, and empty vector controls, and then subjected to blood stage challenge. The heterologous immunization regimen with the antigen pair was more protective than either antigen alone or both antigens delivered with a single vaccine platform, based on their ability to induced the longest pre-patent period and time to peak parasitemia; the lowest peak and mean parasitemia; the smallest area under the parasitemia curve and the highest self-cured rate. Overall, pre-challenge MSP1 antibody titers strongly correlated with decreased parasite burden. Nevertheless, a significant proportion of immunized animals developed anemia. In conclusion, P. vivax plasmid DNA/Ad5 vaccine encoding blood stage parasite antigens AMA1 and MSP142 in a heterologous prime/boost immunization regimen, provided significant protection against blood-stage challenge in Aotus monkeys, indicating the suitability of these antigens and regimen for further development.

    5. Electron Recirculation in Electrostatic Multicusp Systems: II - System Performance Scaling of One-Dimensional ’Rollover’ Wells

      Science.gov (United States)

      1992-01-01

      GCUSPII.T3;vers 3; 07/31/92> AMA C D-A257 942 Electron Recirculation In Electrostatic Multicusp Systems: II - System Performance Scaling Of One...1 * criteria necessary for effective electron confinement in Polywelltf--type multicusp systems. These special polyhedral configurations 7. s allow...anisotropic radial energy in both species, in multicusp Polywelltm geometry. The bulk problem is treated as one-dimensional, with arbitrary spatial

    6. 新媒体环境下高校辅导员职业能力提升的路径选择%On What CoIIege Advisors ShouId Do to Upgrade Their OccupationaI AbiIity in the New Media Environment

      Institute of Scientific and Technical Information of China (English)

      岳甜; 范高社; 杨华

      2015-01-01

      新媒体环境下高校辅导员群体因教育对象、教育环境及教育主体自身发生的深刻变化,亟待提升符合新媒体要求的沟通表达能力、传播主流价值观的理论教育能力、面向实践提炼问题的调查研究能力,构建更为全面的高校辅导员职业能力体系,实现从工作内容、工作实践、角色定位到培养方式、评价体系等方面的观念“转变”。%As the educational objects ,educational environment and the educational main body itself un-dergo dramatic change in the New Media environment ,college advisors urgently need to upgrade their communicative ability in order to meet the requirements of the New Media ,their theoretical education ability in order to spread mainstream values and their investigation and research ability to identify problems in practice .A comprehensive and complete college advisors occupational ability system calls for conceptual change in aspects from job content ,working practice ,role definition to training mode and evaluation system .

    7. Assessing Impact of Distributions and Dependencies in Analysis of Alternatives of System of Systems: Phase 3

      Science.gov (United States)

      2013-12-19

      Future Work ..................................................................................................... 51 3.4 Mechanism Design Approach for...systems that fulfill requirements and capabilities. Our work also includes development of mechanism -based design strategies for managing...area safety system $151.7 P16 : Traffic management advisor $135.5 P17: Precision runway monitor $145.8 P18: En route communication gateway

    8. Analyzing Automated Instructional Systems: Metaphors from Related Design Professions.

      Science.gov (United States)

      Jonassen, David H.; Wilson, Brent G.

      Noting that automation has had an impact on virtually every manufacturing and information operation in the world, including instructional design (ID), this paper suggests three basic metaphors for automating instructional design activities: (1) computer-aided design and manufacturing (CAD/CAM) systems; (2) expert system advisor systems; and (3)…

    9. 75 FR 4054 - Sunshine Act; Notice of Virtual Public Forum for EAC Board of Advisors

      Science.gov (United States)

      2010-01-26

      ... Operations Assessment contains threat trees for the seven types of voting types covered by the Election Operations Assessment. These threat trees are intended to capture risks to the various types of voting systems and the possible mitigations. These threat trees feed into the Risk Assessment tool that will...

    10. Experience with the use of building commissioning advisor - from design to operation

      DEFF Research Database (Denmark)

      Forman, Marianne

      2016-01-01

      - installations services in new buildings and major renovations" it is expected that this consistency can be ensured. Building Commissioning is a comprehensive quality-assurance process that can be used to ensure and document that a building's systems and installations are designed, installed and tested to comply...... consumption in operation. Hence, Copenhagen Property has chosen to test whether the use of a commissioning adviser can contribute to a process that ensures that operation and use of the building is already mainstreamed in the design stage of the building’s technical systems. The method in the research project...... on ethnographic methods and theories, this paper will analyse and discuss what the use of a commissioning adviser in the design stage means for the interaction between design and operation. It may seem that "technical solutions" are made before “ongoing learning processes” in which new themes are articulated...

    11. Web 2.0 Sites for Collaborative Self-Access: The Learning Advisor vs. Google®

      Directory of Open Access Journals (Sweden)

      Craig D. Howard

      2011-09-01

      Full Text Available While Web 2.0 technologies provide motivated, self-access learners with unprecedented opportunities for language learning, Web 2.0 designs are not of universally equal value for learning. This article reports on research carried out at Indiana University Bloomington using an empirical method to select websites for self-access language learning. Two questions related to Web 2.0 recommendations were asked: (1 How do recommended Web 2.0 sites rank in terms of interactivity features? (2 How likely is a learner to find highly interactive sites on their own? A list of 20 sites used for supplemental and self-access activities in language programs at five universities was compiled and provided the initial data set. Purposive sampling criteria revealed 10 sites truly represented Web 2.0 design. To address the first question, a feature analysis was applied (Herring, The international handbook of internet research. Berlin: Springer, 2008. An interactivity framework was developed from previous research to identify Web 2.0 design features, and sites were ranked according to feature quantity. The method used to address the second question was an interconnectivity analysis that measured direct and indirect interconnectivity within Google results. Highly interactive Web 2.0 sites were not prominent in Google search results, nor were they often linked via third party sites. It was determined that, using typical keywords or searching via blogs and recommendation sites, self-access learners were highly unlikely to find the most promising Web 2.0 sites for language learning. A discussion of the role of the learning advisor in guiding Web 2.0 collaborative self-access, as well as some strategic short cuts to quick analysis, conclude the article.

    12. Advancing understanding of the sustainability of lay health advisor (LHA) programs for African-American women in community settings.

      Science.gov (United States)

      Shelton, Rachel C; Charles, Thana-Ashley; Dunston, Sheba King; Jandorf, Lina; Erwin, Deborah O

      2017-03-23

      Lay health advisor (LHA) programs have made strong contributions towards the elimination of health disparities and are increasingly being implemented to promote health and prevent disease. Developed in collaboration with African-American survivors, the National Witness Project (NWP) is an evidence-based, community-led LHA program that improves cancer screening among African-American women. NWP has been successfully disseminated, replicated, and implemented nationally in over 40 sites in 22 states in diverse community settings, reaching over 15,000 women annually. We sought to advance understanding of barriers and facilitators to the long-term implementation and sustainability of LHA programs in community settings from the viewpoint of the LHAs, as well as the broader impact of the program on African-American communities and LHAs. In the context of a mixed-methods study, in-depth telephone interviews were conducted among 76 African-American LHAs at eight NWP sites at baseline and 12-18 months later, between 2010 and 2013. Qualitative data provides insight into inner and outer contextual factors (e.g., community partnerships, site leadership, funding), implementation processes (e.g., training), as well as characteristics of the intervention (e.g., perceived need and fit in African-American community) and LHAs (e.g., motivations, burnout) that are perceived to impact the continued implementation and sustainability of NWP. Factors at the contextual levels and related to motivations of LHAs are critical to the sustainability of LHA programs. We discuss how findings are used to inform (1) the development of the LHA Sustainability Framework and (2) strategies to support the continued implementation and sustainability of evidence-based LHA interventions in community settings.

    13. The internet as a mental health advisor in Germany--results of a national survey.

      Directory of Open Access Journals (Sweden)

      Christiane Eichenberg

      Full Text Available The internet constitutes a popular source of health information. However, the use of the internet and other modern media in the domain of mental health remains widely unclear. This study aimed at exploring the readiness for seeking information online and making use of online counseling and media-assisted psychotherapy. A representative survey of N = 2411 Germans was conducted. Results indicated that more than one fourth of Germans would consider seeking help online in case of psychic strain. Participants reported that they would use the internet when needing to research about mental health topics and to communicate with persons concerned on internet forums. Only a small number of participants had already used psychological online-counseling. The majority of subjects reported not having known about the possibility of online counseling. However, the willingness to make use of this option in the future was in a medium range. Concerning the treatment of mental disorders, participants showed a clear preference toward conventional face-to-face treatment. Less than 10% of participants considered the use of treatment supported by mobile phones, the internet, or virtual realities as likely. Certainly, readiness was significantly higher in persons who were already using the relevant devices--mobile phones, computers, and the internet. In the future, there will presumably be an increasing demand for media-assisted psychological counseling and interventions. Members of the health care system should therefore prepare for current developments and help enlighten patients with regard to the possibilities, and also the potential risks of e-mental health.

    14. DPS Planetary Science Graduate Programs Listing: A Resource for Students and Advisors

      Science.gov (United States)

      Klassen, David R.; Roman, Anthony; Meinke, Bonnie

      2015-11-01

      We began a web page on the DPS Education site in 2013 listing all the graduate programs we could find that can lead to a PhD with a planetary science focus. Since then the static page has evolved into a database-driven, filtered-search site. It is intended to be a useful resource for both undergraduate students and undergraduate advisers, allowing them to find and compare programs across a basic set of search criteria. From the filtered list users can click on links to get a "quick look" at the database information and follow links to the program main site.The reason for such a list is because planetary science is a heading that covers an extremely diverse set of disciplines. The usual case is that planetary scientists are housed in a discipline-placed department so that finding them is typically not easy—undergraduates cannot look for a Planetary Science department, but must (somehow) know to search for them in all their possible places. This can overwhelm even determined undergraduate student, and even many advisers!We present here the updated site and a walk-through of the basic features. In addition we ask for community feedback on additional features to make the system more usable for them. Finally, we call upon those mentoring and advising undergraduates to use this resource, and program admission chairs to continue to review their entry and provide us with the most up-to-date information.The URL for our site is http://dps.aas.org/education/graduate-schools.

    15. Advisor-advisee relationship identification based on maximum entropy model*%基于最大熵模型的导师-学生关系推测*

      Institute of Scientific and Technical Information of China (English)

      李勇军; 刘尊; 于会

      2013-01-01

        导师-学生关系是科研合作网络中重要的关系类型之一,准确识别此类关系对促进科研交流与合作、评审回避等有重要意义.以论文合作网络为基础,依据学生发表论文时通常与导师共同署名的现象,抽象出能够反映导师-学生合作关系的特征,提出了基于最大熵模型的导师-学生关系识别算法.利用DBLP中1990-2011年的论文数据进行实例验证,结果显示:1)关系类型识别结果的准确率超过95%;2)导师-学生关系终止时间的平均误差为1.39年.该方法在识别关系时避免了特征之间相互独立的约束,准确率优于其他同类识别算法,且建模方法对识别社交网络中的其他关系类型也具有借鉴意义.%Research collaboration network has become an essential part in our academic activities. We can keep or develop collaboration relationships with other researchers or share research results with them within the research collaboration network. It is well generally accepted that different relationships have essentially different influences on the collaboration of researchers. Such a scenario also hap-pens in our daily life. The advisor-advisee relationship plays an important role in the research collaboration network, so identification of advisor-advisee relationship can benefit the collaboration of researchers. In this paper, we aim to conduct a systematic investiga-tion of the problem of indentifying the social relationship types from publication networks, and try to propose an easily computed and effective solution to this problem. Based on the common knowledge that graduate student always co-authors his papers with his advisor and not vice versa, our study starts with an analysis on publication network, and retrieves these features that can represent the advisor-advisee relationship. According to these features, an advisor-advisee relationship identification algorithm based on maximum entropy model with

    16. Time-based air traffic management using expert systems

      Science.gov (United States)

      Tobias, L.; Scoggins, J. L.

      1986-01-01

      A prototype expert system was developed for the time scheduling of aircraft into the terminal area. The three functions of the air traffic control schedule advisor are as follows: first, for each new arrival, it develops an admissible flight plan for that aircraft. Second, as the aircraft progresses through the terminal area, it monitors deviations from the flight plan and provides advisories to return the aircraft to its assigned schedule. Third, if major disruptions such as missed approaches occur, it develops a revised plan. The advisor is operational on a Symbolics 3600, and is programed in MRS (a logic programming language), Lisp, and FORTRAN.

    17. Health Care Advisor App

      OpenAIRE

      Espol; Leon Reyes, Moises Gaston; Solano Zambrano, Juan Victor

      2016-01-01

      Las tecnologías de la información y comunicación ocupan un lugar muy importante en la era digital en la que desarrollamos nuestras actividades. Debido al incremento del uso de dipositivos móviles como los teléfonos inteligentes y la tablets, la información se encuentra cada vez más al alcance de todos. En el año 2014 en el Ecuador los hospitales atendieron a 1'212.605 personas que acudieron a los centros de atencion médica; tomando en cuenta esta cifra se debe considerar la cantidad de visita...

    18. 高校校院辅导员团队分层建设探究%Research into Layered Team Construction of College Advisors

      Institute of Scientific and Technical Information of China (English)

      俞世恩

      2011-01-01

      在当前高校辅导员团队建设相对薄弱的情况下,必须根据辅导员专业化、职业化发展的需要,结合高校辅导员队伍建设的整体规划,不断优化队伍结构,既立足于学校层面的团队建设以克服院系工作团队的局限性,又努力培养专业或专项工作带头人,实现与院系团队的功能互补。%In view of the comparatively weak team construction of current college advisors, universities must meet the demand of advisors' professionalization and specialization, combine it with their overall planning of advisors team construction and constantly optimize the team composition. On the one hand, a strong university- level team helps overcome the limitations on the part of school or department level teams; on the other hand, strengthened team construction of leading professionals or specialists is complementary to the school or department level teams.

    19. Decision Support System for Optimized Herbicide Dose in Spring Barley

      DEFF Research Database (Denmark)

      Sønderskov, Mette; Kudsk, Per; Mathiassen, Solvejg K;

      2014-01-01

      Crop Protection Online (CPO) is a decision support system, which integrates decision algorithms quantifying the requirement for weed control and a herbicide dose model. CPO was designed to be used by advisors and farmers to optimize the choice of herbicide and dose. The recommendations from CPO...

    20. Design and implementation of an expert system for the detector control systems of the ATLAS pixel detector; Entwurf und Implementation eines Expertensystems fuer das Detektorkontrollsystem des ATLAS-Pixeldetektors

      Energy Technology Data Exchange (ETDEWEB)

      Henss, Tobias

      2008-12-15

      In the framework of this thesis an expert system ''Pixel-Advisor'' for the control system of the pixel detector was designed and implemented. This supports the operational personnel in the diagnosis and removal of possible problems, which are in connection with the detector control system and unburdens the few available DCS experts.

    1. Modelo Pedagogico de Educacion Primaria para Adultos: Manual para el Asesor de Estudiantes Libres. Primera Parte (A Pedagogical Model for Adult Primary Education: Manual for the Student Advisor. Part One).

      Science.gov (United States)

      Instituto Nacional para la Educacion de los Adultos, Mexico City (Mexico).

      This guide, part of a Mexican series of instructional materials, is intended for advisors of students participating in an adult education program offered through public and private organizations in communities in Mexico. The first part of the program comprises Spanish and math; the second, education for family life, education for community life,…

    2. Professor Darleane C. Hoffman, Senior Advisor & Charter Director Seaborg Institute for Transactinium Science Livermore, California and Dr Marvin Hoffman accompanied by Professor Heinz Gäggeler, University of Bern and Paul Scherrer Institut Villigen.

      CERN Multimedia

      Maximilien Brice

      2001-01-01

      Photo 02 : Visit of Professor Darleane C. Hoffman, Senior Advisor & Charter Director, Seaborg Institute for Transactinium Science, Livermore, California with (from left to right) Dr Mats Lindroos, ISOLDE Technical Coordinator; Professor Heinz Gäggeler, University of Bern and Paul Scherrer Institute Villigen, and Dr Marvin Hoffman.

    3. On How to Rebuild College Advisors'Discourse Power in the We-Media Era%自媒体时代高校辅导员话语权的重塑

      Institute of Scientific and Technical Information of China (English)

      苏伟刚

      2014-01-01

      College advisors conduct ideological education through their discourse .This paper first gives a theoretical interpretation of college advisors'discourse power ,examines the operating mechanisms for advisors'and college students'rights of speech ,and discusses how to rebuild advisors'discourse power in the face of knowledge aphasia ,credibility aphasia ,role aphasia and rational power aphasia .%话语是高校辅导员开展思想教育工作的媒介和手段。本文对自媒体时代高校辅导员话语权进行理论解读,研究高校辅导员与大学生话语权运行机制,阐述高校辅导员面临知识失语、公信力失语、角色失语、理性力量失语等困境,并提出高校辅导员话语权重塑的策略选择。

    4. farmacodependientes: Estudio de casos en la Fundación Ama la Vida I.A.P., desde la teoría de la experiencia del aprendizaje mediado.

      Directory of Open Access Journals (Sweden)

      María Elisa de Lourdes Gutiérrez Díaz

      2006-01-01

      Full Text Available ¿Es posible encontrar una relación entre el Potencial de Aprendizaje y la trayectoria académica caracterizada por niveles escolares inconclusos en los siete jóvenes farmacodependientes? ¿Es posible encontrar una relación entre los Determinantes Distales y la trayectoria académica caracterizada por niveles escolares inconclusos en los siete jóvenes farmacodependientes? La investigación se enmarca en la denominada metodología convergente, combina métodos cuantitativos y cualitativos, pero el mayor interés se encuentra en la perspectiva cualitativa. Se realizó en tres etapas: la primera fue la elaboración del Marco Teórico con base en fuentes documentales diversas. La segunda fue la recopilación y análisis de la información en el campo de trabajo (Fundación Ama la Vida, realizando observación participante, entrevistas y sobre todo aplicando cinco pruebas de la Evaluación Dinámica del Potencial de Aprendizaje a 7 jóvenes. La tercera fue el análisis de los determinantes distales con base en los expedientes de cada sujeto y otras fuentes de información complementarias. Desde el punto de vista del desarrollo cognitivo y del potencial de aprendizaje, los 7 jóvenes demostraron tener la capacidad de retomar los estudios e integrarse al sistema escolarizado. Es más factible que el hecho de haber interrumpido sus trayectorias dentro de instituciones escolares se deba a los determinantes distales (contexto familia, contexto socio-cultural y contexto escolar.

    5. Merging Voices and Finding Harmony in Co-teaching: A Doctoral Student’s Experience of Co-teaching a Music Therapy Course with her Doctoral Advisor

      Directory of Open Access Journals (Sweden)

      Krystal Demaine

      2014-07-01

      Full Text Available This article discusses the author’s experience as a doctoral student who co-taught a graduate level music therapy course with her doctoral advisor. During the course of the teaching semester the doctoral student kept record of her feelings and thoughts in a bi-weekly journal. She explored dynamics such as dual relationships, leadership, and identity as a teacher. Touched with successes and limitations she learned from her experiences and explored insights into collaborative teaching models. Literature related to models of co-teaching, leadership, and mentorship highlighted the journey in this article. Collaborative teaching models may be considered in the field of music therapy to aide in the establishment of integrative and cross disciplinary

    6. 高校辅导员权威的合法性探究--基于马克思·韦伯权威理论%On College Advisors'Legitimate Authority

      Institute of Scientific and Technical Information of China (English)

      周生虎; 杨冠亚

      2016-01-01

      拥有权威是高校辅导员工作开展的前提,马克思·韦伯权威理论久负盛誉,为辅导员权威合法性研究提供了理论指导。韦伯将合法性权威分为传统型、个人魅力型及法理型,作为高校学生教育工作管理工作的从业者,上述三种权威辅导员同样具有。在理清辅导员合法性权威的来源后,应着力研究其巩固路径。权威是一把双刃剑,巩固辅导员合法性权威的同时要注意把握边界,避免其负面影响。%Authority is a prerequisite for advisors'success at work .Study of advisors'legitimate author‐ity can be done under the guidance of Max Weber's theory of authority .Max Weber puts legitimate au‐thority into three categories :traditional type ,personal charisma type and legal principle type .As edu‐cators and supervisors ,college advisors are invested with all the three types of legitimate authority . However ,authority is a double-edged sword .In consolidating advisors'legitimate authority ,efforts must be made to prevent advisors from crossing the boundary so as to avoid the negative conse‐quences .

    7. Decision support systems

      DEFF Research Database (Denmark)

      Jørgensen, L N; Noe, E; Langvad, A M;

      2007-01-01

      system Crop Protection Online is widely used by advisors and as a learning tool for students. Although the system has been validated in many field trials over the years and has shown reliable results, the number of end-users among farmers has been relatively low during the last 10 years (approximately...... 1000 farmers). A sociological investigation of farmers' decision-making styles in the area of crop protection has shown that arable farmers can be divided into three major groups: (a) system-orientated farmers, (b) experience-based farmers and (c) advisory-orientated farmers. The information required...

    8. Systems Fragility: The Sociology of Chaos

      Science.gov (United States)

      2015-03-01

      THE SOCIOLOGY OF CHAOS by Lori R. Hodges March 2015 Thesis Advisor: Robert Josefek Second Reader: Wayne Porter THIS PAGE INTENTIONALLY...SUBTITLE 5. FUNDING NUMBER S SYSTEMS FRAGILITY: THE SOCIOLOGY OF CHAOS 6. AUTHOR(S) Lori R. Hodges 7. PERFORMING OR GANIZATION NA:iVIE(S) AND...INTENTIONALLY LEFT BLANK ii Approved for public release; distribution is unlimited SYSTEMS FRAGILITY: THE SOCIOLOGY OF CHAOS Lori R. Hodges

    9. The process of candidates choose graduate programs: an analysis from the advisor perspective; O processo de escolha de candidatos a programas de Pos-Graduacao: uma analise a partir da perspectiva do orientador

      Energy Technology Data Exchange (ETDEWEB)

      Nascimento, Ridnal Joao do

      2016-11-01

      This study aims to identify the criteria used by advisors in the decision-making on whether to accept a candidate for mentoring in a postgraduate strictu sensu program and examines possible relationships between this decision and their scientific production and mentees evasion. In order to meet these goals one seeks to identify and analyze the selection criteria of candidates for the master's and doctorate programs at an institution; in this case, the Energy and Nuclear Research Institute - IPEN. More specifically, one seeks to study similarities and differences between those criteria among the advisors; find out whether there is a correlation between the selection criteria and the advisors characteristics (Profile); identify the selection process used by advisors and point out which are the motivations that lead to evasion according to their point of view. To meet these challenges, as the starting point of the research, a conceptual model was designed in order to form the basis for the preparation of the script for the interviews with open-ended questions as to identify the selection criteria used by a small group of advisors with a predefined profile. From that point, based on the responses obtained in interviews, the survey was expanded to all advisors working in the IPEN Postgraduate program by implementing an online survey using Google Docs app for data collection. These data were then analyzed and reorganized according to an operational model of research that would guide the analysis by structural equation modeling (SEM) by means of the SmartPLS software, in order to identify the presence or absence of correlation between the criteria adopted by the advisors and their academic production and the evasion of their mentees, for that one relied on studies in: Bazerman and Moore (2010); Cohen (1988); Hair Jr. et al (2009); Hansmann and Ringle (2004); Martins (1997); Ringle, C.; Silva and Bido (2014); Sousa (2007); Sousa and Yu (2014); Torres (2014); Yu (2011

    10. Multi Agent Communication System for Online Auction with Decision Support System by JADE and TRACE

      CERN Document Server

      Martin, A; Madhusudanan, J; 10.4156/jcit.vol4.issue2.martin

      2011-01-01

      The success of online auctions has given buyers access to greater product diversity with potentially lower prices. It has provided sellers with access to large numbers of potential buyers and reduced transaction costs by enabling auctions to take place without regard to time or place. However it is difficult to spend more time period with system and closely monitor the auction until auction participant wins the bid or closing of the auction. Determining which items to bid on or what may be the recommended bid and when to bid it are difficult questions to answer for online auction participants. The multi agent auction advisor system JADE and TRACE, which is connected with decision support system, gives the recommended bid to buyers for online auctions. The auction advisor system relies on intelligent agents both for the retrieval of relevant auction data and for the processing of that data to enable meaningful recommendations, statistical reports and market prediction report to be made to auction participants.

    11. Eocene deep crust at Ama Drime, Tibet

      DEFF Research Database (Denmark)

      Kellett, Dawn; Cottle, John; Smit, Matthijs Arjen

      2014-01-01

      burial and exhumation of a cold subducted slab. The rocks instead resulted from crustal thickening during the early stages of continental collision, and resided in the lower-middle crust for >20 m.y. before they were exhumed and reheated. These new data provide solid evidence for the Indian crust having...

    12. Detection and analysis of the RF(rheumatoid factors),ANA,ASMA and AMA in serum of autoimmune hepatitis patients%自身免疫性肝炎患者血清 RF、ANA、ASMA及AMA检测与分析

      Institute of Scientific and Technical Information of China (English)

      刘小平; 罗海峰; 李建英; 扬朝阳

      2005-01-01

      目的分析自身免疫性肝炎(AIH)患者血清中类风湿因子(RF)与抗核抗体(ANA)、抗平滑肌抗体(ASMA)和抗线粒体抗体(AMA)的相互关系,为临床诊断AIH筛选和确立相应的实验辅助诊断指标.方法收集34例AIH患者血清,采用免疫浊度法检测血清中RF,间接免疫荧光法检测血清ANA、ASMA和AMA.结果患者血清RF的阳性率为67.6%(23/34),ANA、ASMA和AMA的阳性率分别为52.9%(18/34)、17.6%(6/34)和11.7%(4/34),3种自身抗体检出的总阳性率为58.8%(20/34).统计分析显示,RF阳性率与3种自身抗体检出的总阳性率之间无明显差异(P>0.05).此外,20例自身抗体阳性血清均为RF阳性.进一步分析显示,血清RF含量与3种自身抗体阳性率之间具有密切相关性.结论 AIH患者血清中RF阳性率与其ANA、ASMA和AMA 3种自身抗体的阳性率密切相关,提示RF与ANA、ASMA和AMA均可作为实验诊断AIH的辅助参考指标.

    13. Wallach and Allen’ s Ethics Thought of AMAs Design---Review of Moral Mcahines:Teaching Robot s Right from Wrong%论瓦拉赫与艾伦的 AMAs的伦理设计思想--兼评《机器伦理:教导机器人区分善恶》

      Institute of Scientific and Technical Information of China (English)

      王绍源

      2014-01-01

      Along with the development of artificial intelligence technology , artificial moral agent (AMAs) in-creasingly shows a high degree of autonomy and sensibility , making machine (robot ) jump out of science fiction and come true .The reasons are that the world needs good AMAs , necessary moral “Turing test” and the strong ar-tificial intelligence becomes an inevitable trend which also becomes a requirement for the era .Wallach and Allen put forward a “triple distinction” theory on the AMAs ethics orientation , and two methods of ethical design , i.e.“top-down type ( TD)” and “from bottom to top type ( BU) .” Based on the “future scenarios ,” Wallach and Al-len conducted ethical design thought of AMAs which establishes ethical foundation for the development of the future machine (robot).%随着人工智能技术的发展,(技术)人工物道德行为体( AMAs)日益呈现出高度的“自主权”和“感受性”,使得机器(人)走出科幻小说的窠臼。由于世界需要善建AMAs、必要的道德“图灵测试”、强人工智能成为必然趋势,这些成为善建AMAs的时代性要求。瓦拉赫与艾伦提出了“三重区分”理论对AMAs进行了伦理定位,并提出了“自上而下式( TD)”和“自下而上式( BU)”两条伦理设计方法。瓦拉赫与艾伦立足于“未来场景”所进行的AMAs伦理设计思想为未来机器(人)的发展奠定了道德性根基。

    14. Encouraging Self-Directed Group Learning through an E-Portfolio System

      Science.gov (United States)

      Fukuda, Eri; Suzuki, Mitsuko; Hashimoto, Shinichi; Okazak, Hironobu

      2014-01-01

      In this study, the researchers examined how 64 university students engaged in self-directed group learning and used a self-developed e-portfolio system. A sixweek event was held where the students made entries to the e-portfolio individually each week, received feedback from advisors, studied in groups on a voluntary basis, and reflected on their…

    15. Assessing the ESSENCE Biosurveillance System: Results of a User Survey

      Science.gov (United States)

      2011-03-01

      ESSENCE BIOSURVEILLANCE SYSTEM: RESULTS OF A USER SURVEY by Randi M. Korman March 2011 Thesis Advisor: Ron Fricker Second Reader: James...COVERED Master’s Thesis 4. TITLE AND SUBTITLE: Assessing the ESSENCE Biosurveillance System: Results of a User Survey 6. AUTHOR(S) Randi M. Korman 5... Biosurveillance , ESSENCE, NMPHC, Surveillance System, Survey 16. PRICE CODE 17. SECURITY CLASSIFICATION OF REPORT Unclassified 18. SECURITY

    16. Systems Engineering and Integration as a Foundation for Mission Engineering

      Science.gov (United States)

      2015-09-01

      218 –219) describes the uniqueness of systems engineering through its focus on “(1) the product or service as an enabler of the desired user behaviors...final system; humans may be involved in training, maintenance, planning, manufacture , and many aspects of the systems engineering life cycle. As such... ENGINEERING AND INTEGRATION AS A FOUNDATION FOR MISSION ENGINEERING by David F. Beam September 2015 Thesis Advisor: Gary Langford Second Reader

    17. Design and Implementation of a Prototype Database for Part Information to Support the MK92 Fire Control System Maintenance Advisor Expert System

      Science.gov (United States)

      1994-03-01

      REPLJ,[ NodeJ ;* *DoCrnd RwaSQL OSELECT DISTINCTROW 0INTO NEWTX FROM (NODE- REPLJ, REPLACEMENT, INX. REPLACEMtENT INNER JOIN [NODE- RIEPLI ON...REPLJ,( NodeJ ;" DoCuad RimMaco -Wwavg On- End Pumd 132 LIST OF REFERENCES Campbell, T. and Hudnall M~, Ed., ’Test Lab,- COMPiae, PP. 16-36, August 1993

    18. Expert system prototype developments for NASA-KSC business and engineering applications

      Science.gov (United States)

      Ragusa, James M.; Gonzalez, Avelino J.

      1988-01-01

      Prototype expert systems developed for a variety of NASA projects in the business/management and engineering domains are discussed. Business-related problems addressed include an assistant for simulating launch vehicle processing, a plan advisor for the acquisition of automated data processing equipment, and an expert system for the identification of customer requirements. Engineering problems treated include an expert system for detecting potential ignition sources in LOX and gaseous-oxygen transportation systems and an expert system for hazardous-gas detection.

    19. Advancing Understanding of the Characteristics and Capacity of African American Women Who Serve as Lay Health Advisors in Community-Based Settings.

      Science.gov (United States)

      Shelton, Rachel C; Dunston, Sheba King; Leoce, Nicole; Jandorf, Lina; Thompson, Hayley S; Erwin, Deborah O

      2017-02-01

      Lay Health Advisor (LHA) programs hold tremendous promise for reducing health disparities and addressing social determinants of health in medically underserved communities, including African American populations. Very little is understood about the capacity of LHAs in these roles and the broader contributions they make to their communities. This article seeks to address this gap by describing the characteristics and capacity of a sample of 76 female African American LHAs from a nationally disseminated evidence-based LHA program for breast and cervical cancer screening (The National Witness Project), as well as potential differences between cancer survivors and nonsurvivors who serve as LHAs. A conceptual model for understanding LHA capacity and contributions in underserved communities at the individual, social, and organizational levels is presented. We describe LHA experiences and characteristics (e.g., experiences of mistrust and discrimination, racial pride, sociodemographics), capacity at the individual level (e.g., psychological and physical health, health behaviors), capacity at the social level (e.g., social networks, social support), and capacity at the organizational level (e.g., role-related competencies, self-efficacy, leadership, role benefits/challenges). Data were obtained through interview-administered telephone surveys between 2010 and 2011. Findings highlight the critical capacity that LHAs bring to their communities and the importance of supporting LHAs to sustain these programs and to address racial/ethnic health disparities.

    20. On How College Advisors Should Handle Interclass Relationships%高校辅导员对班际关系问题的处理策略

      Institute of Scientific and Technical Information of China (English)

      赵平

      2014-01-01

      团队意识、集体友谊是美好的,而其通常都是用外部的竞争换来的。多数辅导员不能正视这一“不美好”的规律是导致自己所带学生班际关系不和谐的一个重要原因。班际关系紧张不利于集体主义观念的培养,只能产生小团体主义。构建参照团体,一致对外,追求高远目标是班际关系调适的有效路径。%Team consciousness and collective friendship are fine things at the cost of external rivalry. Most advisors cannot see this less-than-beautiful fact in the eye,which in part lead to disharmony between their students and those from other classes.Tense interclass relationships go against collec-tive concept fostering and may result in small-group mentality.Interclass relationships can be effec-tively improved by constructing reference groups and set high and lofty goals.

    1. Outcomes from a community-based, participatory lay health advisor HIV/STD prevention intervention for recently arrived immigrant Latino men in rural North Carolina, USA

      Science.gov (United States)

      Rhodes, Scott D.; Hergenrather, Kenneth C.; Bloom, Fred R.; Leichliter, Jami S.; Montaño, Jaime

      2012-01-01

      Background Latinos in the United States are at increased risk for HIV and sexually transmitted disease (STD) infection. We evaluated the efficacy of a pilot, lay health advisor (LHA) intervention designed to increase condom use and HIV testing among Latino men. Methods Fifteen LHAs (mean age=35.6; range 23–60 years) from 15 Latino soccer teams were trained and worked with their teammates for 18 months. Another 15 teams served as the control group. Data were collected at baseline and 18-months post-LHA training from a random sample of teammates from intervention and control teams. Results Data were collected from 222 men (mean age=29 years) who participated in one of the 30 teams. Relative to the control condition, participants in the intervention reported more consistent condom use in the 30 days preceding follow-up (unadjusted analysis, intervention, 65.6% vs. control, 41.3%; P<.001). Participants in the intervention were more likely to report condom use (adjusted odds ratio=2.3; CI=1.2–4.3) and HIV testing (adjusted odds ratio=2.5; CI=1.5–4.3). Conclusions LHA interventions for Latino men that are developed in partnership with community members, rely on male-centered intrapersonal networks, and are culturally congruent can enhance preventive behaviors and may reduce HIV infection. PMID:19824838

    2. The Odda System: Integration of Conventional Programming and Artificial Intelligence Le système ODDA : intégration de programmation classique et d'intelligence artificielle

      Directory of Open Access Journals (Sweden)

      Cayeux E.

      2006-11-01

      Full Text Available The ODDA system (Offshore Directional Drilling Advisor is an example of how numerical packages, a relational database, graphical interfaces and knowledge bases can be integrated into an industrial application. Le système ODDA (Offshore Directional Drilling Advisor est un exemple illustrant la façon dont des progiciels numériques, une base de données relationnelle, des interfaces graphiques et des bases de connaissances peuvent être intégrés dans une application industrielle.

    3. Arsenic uptake by different species of amaranth and the relationship between arsenic and phosphate in ama-ranth%不同品种苋菜对砷的吸收能力及植株磷砷关系研究

      Institute of Scientific and Technical Information of China (English)

      张骞; 曾希柏; 苏世鸣; 王亚男; 白玲玉; 吴翠霞; 高雪; 贾武霞

      2016-01-01

      利用水培试验方法,研究了不同品种苋菜对As(Ⅴ)的耐性、富集能力及其植株中P、As含量间的关系。结果表明,当营养液中As(Ⅴ)浓度为2 mg·L-1时,As(Ⅴ)促进了花红柳叶、红柳叶苋菜的生长,但对其他品种苋菜的生长有抑制作用;当营养液中As (Ⅴ)浓度达到4 mg·L-1时,As(Ⅴ)对所有品种苋菜的生长都有明显的抑制作用。两种As(Ⅴ)浓度处理下,苋菜不同品种地上部砷含量均为白圆叶苋菜抑红柳叶苋菜>花红柳叶苋菜>花红苋菜>严选红圆叶苋菜。当营养液中As(Ⅴ)浓度为2 mg·L-1时,苋菜地上部P含量与As含量有显著相关性(r=0.881),当营养液中As(Ⅴ)浓度为4 mg·L-1时地上部P、As含量间的相关性不显著,但相关系数达到0.816。苋菜种子中P含量与两种As(Ⅴ)浓度处理下地上部As含量呈显著或极显著相关性(r=0.937,0.971)。%In this study, a hydroponic experiment was conducted to investigate the resistance and accumulation of arsenic(As)in five ama-ranth species at two exposure concentrations of As(2 mg·L-1, 4 mg·L-1)as well as correlation relationship between arsenic and phosphorus contents in amaranth. At the As concentration of 2 mg·L-1, the growths of Huahongliuye and Hongliuye amaranth were improved, but the other three species were inhibited compared with the control without As addition. Differently, the growths of all the five species were signifi-cantly inhibited when the concentration of As increased to 4 mg·L-1. For the two investigated As treatments, As accumulation in the shoot of the five amaranth species ranked in the same order as follows:Baiyuanye>Hongliuye>Huahongliuye>Huahong>Yanxuanhongyuanye. Fur-thermore,the content of phosphorus in amaranth shoot significantly correlated with that of As(r=0.881)at the As concentration of 2 mg·L-1, but insignificant correlation occurred at the As concentration of 4 mg

    4. Space Systems Technology Working Group. Executive Report. Revision

      Science.gov (United States)

      1994-09-01

      technologies associated with VI &I LT protecting or hardening these systems * REDUCE VULNERABILfTY BYBEING HARD TO as they perform designated missions...copy O3 of 100 AD-A285 778 IDA DOCUMENT D-1519 (Revised) EXECUTIVE REPORT SPACE SYSTEMS TECHNOLOGY WORKING GROUP TECHNOLOGY WORKING GP.OUP CO...ADVISOR ELECTE - L. Kirk Lewis • OCT1 Institute for Defense Analyses D9 Norman D. Jorstad G Director, Technology Identification and Analyses Center

    5. HF Over-the-Horizon Radar System Performance Analysis

      Science.gov (United States)

      2007-09-01

      target detection technique and radar equations are applied. Chapter V uses PROPLAB model simulation to bring in the principle of raytracing and... RADAR SYSTEM PERFORMANCE ANALYSIS by Bin-Yi Liu September 2007 Thesis Co-Advisors: Phillip E. Pace Jeffrey B. Knorr THIS PAGE...Thesis 4. TITLE AND SUBTITLE HF Over-the-Horizon Radar System Performance Analysis 6. AUTHOR(S) Bin-Yi Liu 5. FUNDING NUMBERS 7. PERFORMING

    6. DALI - drilling advisor with logic interpretations: methodological issues for designing underbalanced drilling operations. Improving efficiency using case-based reasonic

      Energy Technology Data Exchange (ETDEWEB)

      Santana, Gustavo A.; Velazquez C, David [Mexican Oil Institute, Mexico DF (Mexico)

      2004-07-01

      A system that applies a method of knowledge-intensive case-based reasoning, for repair and prevention of unwanted events in the domain of offshore oil well drilling, has been developed in cooperation with an oil company. From several reoccurring problems during oil well drilling the problem of 'lost circulation', i.e. loss of circulating drilling fluid into the geological formation, was picked out as a pilot problem. An extensive general knowledge model was developed for the domain of oil well drilling. Different cases were created on the basis of information from one Mexican Gulf operator. When the completed CBR-system was tested against a new case, cases with descending similarity were selected by the tool. In an informal evaluation, the two best fitting cases proved to give the operator valuable advise on how to go about solving the new case (author)

    7. A Case Study of Engaging Hard-to-Reach Participants in the Research Process: Community Advisors on Research Design and Strategies (CARDS)®.

      Science.gov (United States)

      Kaiser, Betty L; Thomas, Gay R; Bowers, Barbara J

      2017-02-01

      Lack of diversity among study participants in clinical research limits progress in eliminating health disparities. The engagement of lay stakeholders, such as patient or community advisory boards (CABs), has the potential to increase recruitment and retention of underrepresented groups by providing a structure for gathering feedback on research plans and materials from this target population. However, many CABs intentionally recruit prominent stakeholders who are connected to or comfortable with research and academia and thus may not accurately represent the perspectives of underrepresented groups who have been labeled hard-to-reach, including racial minorities and low-income or low-literacy populations. We developed a partnership between the University of Wisconsin-Madison School of Nursing and two community centers to deliberately engage hard-to-reach people in two lay advisory groups, the Community Advisors on Research Design and Strategies (CARDS)®. Community center staff recruited the CARDS from center programs, including parenting and childcare programs, women's support groups, food pantries, and senior meal programs. The CARDS model differs from other CABs in its participants, processes, and outcomes. Since 2010, the CARDS have met monthly with nurses and other researchers, helping them understand how research processes and the language, tone, appearance, and organization of research materials can discourage people from enrolling in clinical studies. We have successfully used the CARDS model to bring hard-to-reach populations into the research process and have sustained their participation. The model represents a promising strategy for increasing the diversity of participants in clinical research. © 2016 Wiley Periodicals, Inc. © 2016 Wiley Periodicals, Inc.

    8. Identification of the Discrepancies between Pharmacist and Patient Perception of the Pharmacist's Role as an Advisor on Drug Therapy Based on Social Science Theory.

      Science.gov (United States)

      Oshima, Shinji; Senoo, Kazuhiko; Negishi, Akio; Akimoto, Hayato; Ohara, Kousuke; Inoue, Naoko; Ohshima, Shigeru; Kutsuma, Nobuaki; Juni, Kazuhiko; Kobayashi, Daisuke

      2016-01-01

      Article 25-2 of the Japanese Pharmacists' Act was revised in June 2014, establishing the position of pharmacists as "advisors on the use of pharmaceuticals." Prior to the Act's revision, we investigated the perceptions of patients and pharmacists about pharmacists' roles using a social science methodology. We also examined current opinions and necessary factors for the future growth and development of pharmacists. This questionnaire survey was conducted using an internet method. Patients and pharmacists answered 12 questions. Responses from 529 patients and 338 pharmacists were analyzed. For all items, pharmacists' awareness of their roles exceeded patients' awareness of the roles. In this study, the difference between pharmacist and patient awareness was larger than in similar research conducted in the United States. The greatest difference was observed in three items: "Understanding the effects of the drugs the patients are taking" (rate of high ratings: pharmacists 80.2%, patients 37.8%), "Understanding the health changes caused by the drugs dispensed to the patients" (pharmacists 80.2%, patients 28.4%), and "Consciously protecting patients from the adverse effects of drugs" (pharmacists 82.8%, patients 42.2%), indicating role discrepancy. Partition analysis indicated the three factors for a pharmacist to be regarded as a drug therapy or medication specialist: "The patient regards the pharmacist as his/her family or regular pharmacist," "The pharmacist is making it easy for a patient to talk with him/her" and "The pharmacist is aware of a patient's use of products other than prescribed drugs, such as over the counter (OTC) medications or health foods and nutritional supplements." Future efforts are necessary to resolve role discrepancy and implement ongoing monitoring.

    9. Trol ve uzatma ağları ile İzmir körfezinden yakalanan dil (Solea solea balığının yaşama yüzdesi; kültür şartlarına adaptasyonu ve beslenme davranışı.

      Directory of Open Access Journals (Sweden)

      Doç.Dr. Fatih Başaran

      2008-01-01

      Full Text Available Trol ve uzatma ağları ile İzmir körfezinden yakalanan dil (Solea solea balığının yaşama yüzdesi; kültür şartlarına adaptasyonu ve beslenme davranışı. Bu araştırmada, doğal ortamdan yakalanan dil balığının (Solea solea, kültür şartlarına adaptasyonu ve beslenme davranışı incelenmiştir. Dil balıkları, 2007 Mart-Nisan döneminde, İzmir Körfezi’nden trol ve uzatma ağlarıyla yakalanmıştır. 270 adet dil balığının ön adaptasyonu sırasında, ilk beş gün boyunca, karanlık ortamda antibiyotik (100 ppm fruzolidon ilavesi, 60 dak/gün uygulaması gerçekleştirilmiştir. Kültür şartlarında ilk besleme için, kalamar (Loligo vulgaris, boru kurdu (Diopatra neopolitana, kara midye (Mytilus galloprovincialis, sülünes (Solen marginatus, istiridye (Ostrea edulis, japon şapkası (Patella spp., deniz salyangozu (Monodonta turbinata ve taze sardalya (Sardina pilchardus kullanılmıştır. Dil balıkları 0-2 gün içinde beslenmeye başlamıştır ve boru kurdu, en çok tercih ettikleri tür olmuştur. Bir aylık adaptasyon dönemi sonunda, uzatma ağlarıyla yakalanan dil balıklarının yaşama oranının (%58, trol ile yakalananların yaşama oranından (%29 önemli düzeyde yüksek bulunmuştur (p

    10. Design and Implementation of a Three-Tiered Web-Based Inventory Ordering and Tracking System Prototype Using CORBA and Java

      Science.gov (United States)

      2000-03-01

      w- Primary Memory T ^ Interpreter ^ Figure 12. Typical Java Environment ( Deitel ...1998. Booch, G., Object-Oriented Analysis and Design with Applications, Second Edition, Addison-Wesley, 1994. Deitel , H., Deitel , P., Java How to...TRACKING SYSTEM PROTOTYPE USING CORBA AND JAVA by Ahmed Otoom March 2000 Thesis Advisors: Daniel R. Dolk James Bret Michael Approved for public

    11. TripAdvisor^{N-D}: A Tourism-Inspired High-Dimensional Space Exploration Framework with Overview and Detail.

      Science.gov (United States)

      Nam, Julia EunJu; Mueller, Klaus

      2013-02-01

      Gaining a true appreciation of high-dimensional space remains difficult since all of the existing high-dimensional space exploration techniques serialize the space travel in some way. This is not so foreign to us since we, when traveling, also experience the world in a serial fashion. But we typically have access to a map to help with positioning, orientation, navigation, and trip planning. Here, we propose a multivariate data exploration tool that compares high-dimensional space navigation with a sightseeing trip. It decomposes this activity into five major tasks: 1) Identify the sights: use a map to identify the sights of interest and their location; 2) Plan the trip: connect the sights of interest along a specifyable path; 3) Go on the trip: travel along the route; 4) Hop off the bus: experience the location, look around, zoom into detail; and 5) Orient and localize: regain bearings in the map. We describe intuitive and interactive tools for all of these tasks, both global navigation within the map and local exploration of the data distributions. For the latter, we describe a polygonal touchpad interface which enables users to smoothly tilt the projection plane in high-dimensional space to produce multivariate scatterplots that best convey the data relationships under investigation. Motion parallax and illustrative motion trails aid in the perception of these transient patterns. We describe the use of our system within two applications: 1) the exploratory discovery of data configurations that best fit a personal preference in the presence of tradeoffs and 2) interactive cluster analysis via cluster sculpting in N-D.

    12. Título da página electrónica: Projecto AmaZone – A Onça, a diferença e o pensamento ameríndio: uma construção contra-hegemónica e colectiva

      Directory of Open Access Journals (Sweden)

      Túlio de Souza Muniz

      2012-10-01

      Full Text Available Desde 2005, está em curso na Internet uma experiência inovadora de construção híbrida e colectiva de um pensamento filosófico baseado na vida e experiências dos povos indígenas da América do Sul e na agregação de estudos sobre e com eles. Por iniciativa do etnólogo Eduardo Viveiros de Castro, do Museu Nacional do Rio de Janeiro, o Projecto AmaZone, conforme apresentaçao do próprio site, “é a migração para o formato wiki de um estudo intitulado A Onça e a Diferença, em preparação desde 1997. E...

    13. The entomologist as a science partner and curriculum advisor: The Earth School model for grades 6--8

      Science.gov (United States)

      Marshall, Bethany Johnston

      The Earth School model for creation of partnerships between university scientists and public schools began with a traditional research project involving the study of macroinvertebrate recolonization of agriculturally based restored wetlands. From fieldwork designed to address hypotheses of community composition over time, protocols and equipment evolved for application in middle-school classrooms. In addition to classroom teachers guiding their students in replicating active scientific research, the inclusion of a science partner was key to the success of this model. To ensure that the classroom teachers were themselves comfortable as researchers, monthly staff development workshops were conducted as a component of the Earth School model. The use of entomology as a unifying theme for educational scientific investigation lets the student explore virtually every other system in the biosphere. Because of the unparalleled survivability and adaptability of insects, we can find examples from all biomes, all time references and all disciplines. Over the course of long-term continuous exploration, learners become familiar with relationships and patterns evident in natural situations. These same patterns of birth, growth and decay are much more vividly demonstrated in the field than in textbooks. Similarly, concrete examples of feeding relationships between organisms are plentiful in nearly any outdoor situation. The following model incorporates current research from multiple scientific disciplines but focuses on the many and varied research activities offered by the entomological community. Teachers and students in a primarily urban setting made extensive use of the materials developed through the course of this model's development. Their feedback as the materials were integrated into an established curriculum allowed for the fine-tuning of activity development. A conversion template has evolved that gives teachers, curriculum directors, parents and other educators a

    14. Software and Systems Test Track Architecture and Concept Definition

      Science.gov (United States)

      2007-05-01

      Raytheon, the Embedded Systems Consortium for Hybrid and Embedded Research ( ESCHER ) Research Institute, Vanderbilt University, and the University of...Stuart ESCHER PM: Larry Rohrbough UC Berkeley Co-PI: Prof. Shankar Sastry Tech Lead: Dr. Jonathan Sprinkle Vanderbilt Co-PI: Dr. Ted Bapty Advisor: Dr...Andrew Vandivort contributed greatly to the development of the SWTT CONOPS, and Don Wilson provided strategic technology leadership. From ESCHER

    15. Decision support systems

      DEFF Research Database (Denmark)

      Jørgensen, L N; Noe, E; Langvad, A M

      2007-01-01

      system Crop Protection Online is widely used by advisors and as a learning tool for students. Although the system has been validated in many field trials over the years and has shown reliable results, the number of end-users among farmers has been relatively low during the last 10 years (approximately...... 1000 farmers). A sociological investigation of farmers' decision-making styles in the area of crop protection has shown that arable farmers can be divided into three major groups: (a) system-orientated farmers, (b) experience-based farmers and (c) advisory-orientated farmers. The information required...... by these three groups to make their decisions varies and therefore different ways of using decision support systems need to be provided. Decision support systems need to be developed in close dialogue and collaboration with user groups....

    16. The psychiatrist as moral advisor.

      Science.gov (United States)

      Redmon, R B

      1989-12-01

      This paper is a critique of a paper by Robert Lipkin. Arguments for the following claims are put forward: (1) that what is 'essential' to the psychiatric relationship is what we want it to be for utilitarian reasons; (2) it would not be to our advantage to allow the medicalization of morality; (3) what we should expect from the psychiatrist is prudential advice, not moral advice, and that Lipkin has a confused view about the relationship between these two areas; and (4) we should not allow the psychiatrist to restrict individuals on moral grounds, but only on public safety grounds.

    17. Extrinsic Motivation of Part time Advisors and the Influencing Factors%高校兼职辅导员激励效果及影响因素探究--以中国人民大学为例

      Institute of Scientific and Technical Information of China (English)

      关一

      2014-01-01

      From the perspective of management science,this paper examines questionnaire surveys and interviews the extrinsic motivation of part time advisors from Renmin University of China and the in-fluencing factors in the hope of finding the relationships between the various motivators and the advi-sors'psychological expectations so universities can better manage and motivate part time advisors.%文章从管理学角度,通过问卷调查和访谈法,分析了中国人民大学兼职班级辅导员的激励效果现状及影响因素,找出影响大学生兼职辅导员激励效果的各类要素和辅导员心理期望之间的关系,对高校兼职辅导员的管理、激励提出建议。

    18. 高校辅导员博客现状分析及对策--以中国大学生在线网为例%Current Situation of College Advisors'Blogging and Countermeasures

      Institute of Scientific and Technical Information of China (English)

      王钰; 张勇

      2014-01-01

      本文运用传播学议程设置理论以及内容分析法对中国大学生在线推荐前十名辅导员博客进行研究,反映出辅导员博客文章数较多、文章内容涉及多方面、报道类信息时效性不强的现状,并总结出博客应具备议程设置意识、突出博客的多种功能、注重内容美与形式美相统一的对策。%This paper,using the Agenda setting Theory and Textual Analysis of communications, examines the top ten advisors'blogs recommended online by college students.It finds out that advisors writes blogs quite frequently about many things but with poor timeliness in information.The paper concludes that bloggers must have agenda setting consciousness,give play to the multiple functions of blogging and pay attention to the beauty of both content and form.

    19. The design of the AIE: An object-oriented application development system

      Energy Technology Data Exchange (ETDEWEB)

      Fuja, R.S.; Widing, M.A.

      1992-02-27

      Three years ago, in response to our challenging development context, the Advanced Modeling and Analysis Section designed and implemented an object-oriented environment -- the Application Interface Engine (AIE). Our prototyping requirements forced existing application development systems beyond their capabilities. Programmers at AMAS and its contractors have developed over twenty applications using AIE. Our initial experience has been very positive. AIE extends an object-oriented programming language with syntax and classes to support applications specification. This extended system improves all stages of the application engineering life cycle, from rapid prototyping to long term maintenance.

    20. The Robot of Deficient Emotion Needs Moral Care?---Robot’s Emotional Factors in the Future AMAs%无情感的机器人需要道德关护吗?--未来AMAs机器人的情感因素分析

      Institute of Scientific and Technical Information of China (English)

      王绍源; 张伟伟

      2014-01-01

      The current application field of robot is lack of emotion conditions ,such as consciousness, mental state and feeling ect. Robot is in accordance with the procedures which human sets certain rules to behave. That a robot can be called artifact moral agents (AMAs) seems to depend on whether the robot has the emotional factors. There is a closely relationship between morality and emotion. However, Behaviorism and expressionism consider that robot should also be ethical care ,even though they lack of emotion. From the perspective of the application practice of the robot, no matter the robots of cognitive impairment, robot of slave role or robot of property role, they all have the corresponding moral status. They should be given different ways of ethical caring. With the development of artificial intelligence, we believe that we will be able to create a kind of emotional AMAs robot in the future.%目前应用领域的机器人缺乏意识、精神状态和感觉这些情感条件,机器人只是按照人类设定的程序进行遵循一定的规则行为。判定一个机器人能否称得上人工物道德行为体(AMAs),似乎取决于是否具有情感因素。道德与情感之间有着紧密联系的关系。然而,行为主义和表现主义认为,即使缺乏情感的机器也应当受到道德关护。从机器人的应用实践来看,无论是认知缺陷角色的机器人、奴仆角色机器人还是财产物角色机器人,他们都有相应的道德地位,都应当受到不同方式的伦理关护。随着人工智能的发展,我们认为,未来我们一定能够制造出一种具有情感的AMAs机器人。

    1. Does Asimov's“Three Laws of Robotics”Fits to AMAs Robots Building in the Future?---An Analysis Based on Bicentennial Man%阿西莫夫的“机器人三定律”适合未来AMAs机器人的构建吗?--基于《机器人管家》的文本反思

      Institute of Scientific and Technical Information of China (English)

      武威利; 王绍源

      2016-01-01

      随着近年来应用伦理学新兴领域“机器人伦理学”的勃兴,人们开始探讨未来AMAs机器人的构建问题。现代美国科幻文学大师艾萨克·阿西莫夫的“机器人系列”等科幻文学成为探讨机器人伦理学的最早文本。其中在以“机器人三定律”为理论基点撰写的《机器人管家》(Bicentennial Man)中,映射出诸多机器人元伦理学问题。对机器人获得道德地位的必要性特征进行探讨,有助于人们以审慎的态度正视“机器人三定律”对未来AMAs机器人的建构作用。正视“机器人三定律”的理论缺陷并对其反思与修正,旨在为构建完备的AMAs机器人提供一种思想质料和理论借鉴。%In recent years,as applied ethics "robot ethics" emerges,ethicists began to explore build prob-lems of AMAs robots in the future. Modern American science fiction literature master Isaac asimov's "robot se-ries" is the earliest prototype of robot ethics. He put“three laws of robotics”into the basis of his literatures. The classic literature Bicentennial Man maps many problems of robots metaethics. That discussing the characteristics of robot for the necessity of the moral status can help people understand“Three laws of robotics”in a prudent at-titude. Faced up to the defects of“three laws of robotics”,we can amend theory and aim to build a perfect AMAs robot in the future.

    2. Student Advisors'Ethical Straits and Professional Burnout Adjustment in Medical Colleges%医学院校辅导员伦理困惑与职业倦怠的调适

      Institute of Scientific and Technical Information of China (English)

      胡其图

      2011-01-01

      医学院校辅导员出现的伦理困惑和职业倦怠如不及时纠正,不仅危害大学生的学业和日常生活,还会导致教育质量的降低.针对医学院校辅导员出现的人际关系紧张、职业兴趣降低、职业焦虑、职业角色矛盾、价值观冲突等伦理困惑与职业倦怠症状,应采取加强辅导员人文关怀、提高辅导员经济收入、关注辅导员心理健康等措施;探索辅导员转业新路径,集合各方力量建立有效的激励机制,进行有效的职业道德和职业意义教育;提升医学院校辅导员自我认同感,及时、有效地纠正、疏导其伦理困惑与职业倦怠.%Recent studies show student advisors in medical colleges are vulnerable for ethical straits and professional burnout. If not corrected in time , they would not only be harmful to students' daily study and life, but also cause a drop in the quality of college education. A series of countermeasures should be taken immediately, aiming at handling medical student advisors' syndromes of ethics straits and professional burnout including tension in interpersonal relationship, loss of professional interest, professional anxiety, professional roles contradiction, and moral concepts conflicts. Concrete countermeasures include strengthening humanistic concern for student advisors in medical colleges, increasing their income, paying close attention to their mental health, exploring possible choices of future professional transference, establishing an effective motive mechanism by comprehensively unifying all parties involved, providing professional ethics and professional significance education, and improving their identity acceptance, etc.

    3. Working Together: Planting the Seed. "Kia Pihi Ai Te Mahi Ngatahi." Proceedings of the 2012 Annual International Conference of the Association of Tertiary Learning Advisors of Aotearoa/New Zealand (ATLAANZ) (Hamilton, New Zealand, Nov 21-23, 2013). Volume 8

      Science.gov (United States)

      Gera, Christina, Ed.

      2013-01-01

      The 7 articles in this 8th volume comprise the referred proceedings of the 2012 ATLAANZ (Association of Tertiary Learning Advisors Aotearoa/New Zealand) conference. The first three chapters present tools that can assist students with their academic development: In chapter 1, ("The DELNA Language Advisory Session: How do Students…

    4. National Science Foundation Assistant Director for Mathematics and Physical Sciences Tony Chan (USA) visiting CMS experiment on 23rd May 2007 with Spokesperson T. Virdee, Deputy Spokesperson R. Cousins, Advisor to CERN Director-General J. Ellis, US CMS Research Program Deputy Manager D. Marlow and FNAL D. Green

      CERN Multimedia

      Maximilien Brice

      2007-01-01

      National Science Foundation Assistant Director for Mathematics and Physical Sciences Tony Chan (USA) visiting CMS experiment on 23rd May 2007 with Spokesperson T. Virdee, Deputy Spokesperson R. Cousins, Advisor to CERN Director-General J. Ellis, US CMS Research Program Deputy Manager D. Marlow and FNAL D. Green

    5. Los padres como consejeros o coparticipes en la toma de decisiones. Serie E: [E1] logro de la participacion de los padres. cuaderno 3. Edicion para el maestro. Cuadernos para el entrenamiento de maestros de educacion bilingue. (Parents as Advisors or Participants in Decision Making. Series E: Parent Participation, Book 3. Teacher Edition. Bilingual Education Teacher Training Packet).

      Science.gov (United States)

      Rodriguez, Rodolfo, Comp.

      This guide on training bilingual education teachers focuses on parents as advisors in the decision making process at bilingual schools. The two units, "An Introduction to Parent Participation" and "Parent Participation in Educational Decision Making," include objectives, definitions of terms, lists of materials and equipment, and learning…

    6. 新媒体视域下高校辅导员媒介素养的提升研究*--以安徽省芜湖市2所高校为例%On How to Improve College Advisors'Media Literacy in the Context of New Media

      Institute of Scientific and Technical Information of China (English)

      王夏露

      2014-01-01

      通过调查问卷的方式对安徽省芜湖市2所高校的辅导员进行调研,分析高校辅导员媒介接触、媒介认知、媒介应用、媒介批判、媒介道德、媒介素养及媒介素养教育认知等方面状况,从树立媒介素养主体意识和建立培训平台等方面提出了提高高校辅导员媒介素养的可行性对策和建议。%Based on questionnaire surveys of advisors from two Wuhu based colleges,this paper gives an analysis of college advisors'media exposure,media recognition,media application,media criticism, media ethics and media literacy,etc.Then it offers some workable suggestions and countermeasures for improvement of college advisors'media literacy,including increasing advisors'subj ect conscious-ness and building good training platforms.

    7. William Brinkman (centre), Director of the Department of Energy, U.S.A. at the superconducting magnet test hall SM18 with (from left to right) Coordinator for External Relations F. Pauss, Advisor for Non-Member States J. Ellis, J. Strait from Fermilab and Deputy Head of Technology Department L. Rossi on 13 November 2009.

      CERN Multimedia

      Maximilien Brice; SM18

      2009-01-01

      William Brinkman (centre), Director of the Department of Energy, U.S.A. at the superconducting magnet test hall SM18 with (from left to right) Coordinator for External Relations F. Pauss, Advisor for Non-Member States J. Ellis, J. Strait from Fermilab and Deputy Head of Technology Department L. Rossi on 13 November 2009.

    8. Control System Design Language Implementation of a Gas Turbine Starting Controller.

      Science.gov (United States)

      1984-06-01

      THESIS _ CONTROL SYSTEM DESIGN LANGUAGE IMPLEMENTATION OF A GAS TURBINE STARTING CONTROLLER by Richard Preston Riley June 1984 *1Thesis Advisor: A. A...CONTRACT OR GRANT NUM11101(s) Richard Preston Riley S. P01111SOMNM @R11ANS ATION NAME AND ADDRESS iG. PROGRAM ELEMENT. PROJECT. TASKAREA A WORKC UNIT...Design Language Implementation of a Gas Turbine Starting Controller by *J.4 Richard Preston Riley Lieutenant Commander, United States Navy B.S

    9. Improving energy efficiency in agriculture - Proposal for the design of advisory systems; Energieffektivisering inom jordbruket - Foerslag till utformning av raadgivningssystem

      Energy Technology Data Exchange (ETDEWEB)

      Einarson, Elin; Hagerberg, Anna; Linder, Camilla; Sten, Roland; Vannesjoe, Binella; Holmberg, Rurik

      2011-07-01

      This report describes the results of a study that the Board of Agriculture has carried out after consultation with the Energy Agency. The aim is to give proposals for the design of a counseling system for improving energy efficiency in the agricultural sector. Such an advisory system should be designed as group counseling combined with a single advisors' visit on the farm. Board of Agriculture suggests that counseling is done within existing environmental counseling in the project 'Greppa Naeringen'. It is estimated that the counseling can reach 800-1500 participants during the period 2011-2013. The number of farmers that can be reached is limited by the budget available to the project but also by the number of active advisors

    10. The perspectives of Brazilian homemakers concerning living with type 2 diabetes mellitus La perspectiva de ama de casa brasileña sobre la vida con diabetes mellitus tipo 2 As perspectivas de donas de casa brasileiras sobre a sua experiência com diabetes mellitus tipo 2

      Directory of Open Access Journals (Sweden)

      Denise Maria Guerreiro Vieira da Silva

      2012-06-01

      Full Text Available The purpose of this study is to present an understanding of the experience of Brazilian homemakers with type 2 diabetes mellitus (DM2. A descriptive exploratory design was used and semi-structured interviews were conducted with 25 Brazilian homemakers concerning their experience. The interviews were recorded, transcribed, and the resulting text was analyzed using the sequential step method. Data converged to one dominant category, "constructing one's identity in the family context", which is comprised of three categories: gender differences; day-to-day concerns; and incongruity between knowledge and behavior related to DM2. These findings suggest that participants construct their identities within the family context and that their experience of living with DM2 is integral to their self-identification as wives and mothers. This, in turn, has implications for the design and implementation of programs to assist women in managing DM2 effectively.El propósito de este estudio es comprender la experiencia de las amas de casa brasileñas con la diabetes mellitus tipo 2 (DM2. Se empleo un abordaje exploratorio descriptivo, donde participaron de las entrevistas 25 amas de casa de Brasil acerca de su experiencia con el DM. Las entrevistas fueron grabadas, transcritas y el texto resultante se analizó mediante el método secuencial de cuatro etapas: aprensión, síntesis, teorización y transferencia. Los datos se reunieron en un tema dominante: "construyendo su identidad en el contexto familiar", que se compone de tres sub-temas: las diferencias de género, las preocupaciones del cotidiano y la incongruencia entre el conocimiento y el comportamiento relacionado con DM2. Estos hallazgos sugieren que los participantes construyen su propia identidad dentro del contexto familiar y que su experiencia de vivir con DM2 es parte integral de su identificación como esposas y madres. Esto, a su vez, tiene implicaciones para el planeamiento e implementación de

    11. Performance evaluation of the distance education system with fuzzy logic

      Science.gov (United States)

      Armaǧan, Hamit; Yiǧit, Tuncay

      2017-07-01

      Distance education is a kind of education that brought together course advisor, student and educational materials in a different time and place through communicational technologies. In this educational system the success of education is directly related to audio, video and interaction. In this study, a model is created by using fuzzy logic with the success of distance education students and the components of distance education. This study is made by MATLAB fuzzy logic toolbox. Audio, video, educational technology, student achievement are used as parameters in the evaluation. System assessment is carried out depending on parameter.

    12. Analysis of Maths Learning Activities Developed By Pre-service Teachers in Terms of the Components of Content, Purpose, Application Methods [Öğretmen Adaylarının Geliştirdikleri Matematik Öğrenme Etkinliklerinin Seçilen Konu, Amaç, Uygulama Şekli Bileşenleri Açısından Analizi

      Directory of Open Access Journals (Sweden)

      Çağla Toprak

      2014-04-01

      Full Text Available Today- when the influence of the alteration movement done in order to keep up with the age of the educational system is still continuing- the importance of teachers in students’ learning and achieving what is expected from the education system has been stated by the studies conducted (Hazır & Bıkmaz, 2006. Teachers own a critical role in the stage of both preparing teaching materials and using them (Stein & Smith, 1998b; Swan, 2007. When the existing curriculums –in particular, maths and geometry cirriculums- are analyzed, it can be observed that activities are the most significant teaching materials (Bozkurt, 2012. In fact, it is possible to characterize the existing curriculums as activity-based ones (Report of Workshop Examining Content of Primary School Curriculums According to Branches, 2010; Epö, 2005. Therefore, what sort of learning activities there are, what qualities they need to have, how to design and apply them are topics that must be elaborated (Uğurel et al., 2010. At this point, our study to increase the skills of pre-service teachers during the process of developing activities was conducted with 27 pre-service teachers -19 girls 8 boys- studying in the 4th year in Mathematics Education Department at a state university in the Aegean Region. The activity designs the pre-service teachers developed considering the patterns given after a series of practice were analyzed in documents in terms of the aim of design and the form of practice. As a result of the studies, it is observed that pre-service teachers deal with the topics from the maths curriculum and these topics are of different grade levels. The result of the examination named as target component suggests that activities developed aim firstly at providing learning and this is followed by reinforcing the concepts already learned. It is stated that pre-service teachers prefer mostly small group (cooperative studies in the activities they develop. [Today- when the

    13. „Þessi komment, mér finnst þau eiginlega mesta gullið.” Áhrif og notagildi upplýsinga á Trip Advisor.

      OpenAIRE

      Brynja Guðjónsdóttir 1986

      2014-01-01

      Rannsóknarverkefni þetta fjallar um viðhorf ferðamanna til vefsíðunnar Trip Advisor þar sem áhersla er lögð á að afla sér upplýsinga um vöru eða þjónustu út frá myndum, einkunnum eða stjörnugjöf og umsögnum annarra. Markmið rannsóknarinnar var að kanna hver áhrifin verða þegar notendur upplifa jákvæðar eða neikvæðar myndir, einkunnir eða stjörnugjafir og umsagnir. Einnig var það haft að markmiði að kanna hvaða þættir reyndust ferðamönnum mikilvægastir við upplýsingaöflun og af hverju. Með það...

    14. Analysis of Research into College Advisors'Quality in the Past 20 Years%近二十年来高校辅导员素质研究内容分析

      Institute of Scientific and Technical Information of China (English)

      祁明; 朱华珍; 陈华; 江鸿波

      2014-01-01

      本研究以近20年国内出版的关于“高校辅导员素质”的期刊论文为对象,以内容分析为主要研究方法,对论文数量、研究人员情况、论文所属研究项目、研究类型及论文主体内容进行了编码统计。结果显示相关领域研究数量有限,研究质量有待提高,定性研究为主,定量研究不足,研究成果有限,研究影响有待扩大。%T his paper studies journal articles on college advisors'quality published in the past 20 years . Focusing on content analysis ,the paper also provides coding statistics of the number of the articles , the research w riters ,the projects ,the types and the subject matters .It reveals that the above-men-tioned journal articles are limited in number and less than high in quality .T hey are mainly qualitative researches ,giving only inadequate consideration to the quantitative method ,and naturally the results are limited in both scope and influence .

    15. An Intelligent Natural Language Conversational System for Academic Advising

      Directory of Open Access Journals (Sweden)

      Edward M. Latorre-Navarro

      2015-01-01

      Full Text Available Academic advisors assist students in academic, professional, social and personal matters. Successful advising increases student retention, improves graduation rates and helps students meet educational goals. This work presents an advising system that assists advisors in multiple tasks using natural language. This system features a conversational agent as the user interface, an academic advising knowledge base with a method to allow the users to contribute to it, an expert system for academic planning, and a web design structure for the implementation platform. The system is operational for several hundred students from a university department. The system performed well, obtaining close to 80%, on the traditional language processing measures of precision, recall, accuracy and F1 score. Assessment from the constituencies showed positive and assuring reviews. This work provides an assessment and technological solution to the academic advising field, i.e., the first-known advising multi-task conversational system with adaptive measures for improvement. The evaluation in a real-world scenario shows its viability, and initiated the development of a corpus for academic advising, valuable for the academic and language processing research communities.

    16. A Personalized System for Conversational Recommendations

      CERN Document Server

      Goker, M H; Thompson, C A; 10.1613/jair.1318

      2011-01-01

      Searching for and making decisions about information is becoming increasingly difficult as the amount of information and number of choices increases. Recommendation systems help users find items of interest of a particular type, such as movies or restaurants, but are still somewhat awkward to use. Our solution is to take advantage of the complementary strengths of personalized recommendation systems and dialogue systems, creating personalized aides. We present a system -- the Adaptive Place Advisor -- that treats item selection as an interactive, conversational process, with the program inquiring about item attributes and the user responding. Individual, long-term user preferences are unobtrusively obtained in the course of normal recommendation dialogues and used to direct future conversations with the same user. We present a novel user model that influences both item search and the questions asked during a conversation. We demonstrate the effectiveness of our system in significantly reducing the time and nu...

    17. Marketing na društvenim mrežama

      OpenAIRE

      Stanojević, Marija

      2011-01-01

      Društvene mreže kao što su Facebook, MySpace, LinkedIn, YouTube, Flicker, Digg, Foursqare i brojne druge, promijenile su način na koji demografska populacija ljudi do 35 godina komunicira (ili ne komunicira?) sa svijetom, kako kupuje i kako se informira. Došlo je vrijeme digitalnog stila života! Internet je svojim intenzivnim razvojem postao značajan marketinški medij koji će u budućnosti biti nezaobilazni faktor poslovanja tvrtki. Pojavom društvenih mreža došlo je do značajnih promjena u...

    18. Low-level radioactive wastes. AMA Council on Scientific Affairs.

      Science.gov (United States)

      1990-02-01

      Under a federal law, each state by January 1, 1993, must provide for safe disposal of its low-level radioactive wastes. Most of the wastes are from using nuclear power to produce electricity, but 25% to 30% are from medical diagnosis, therapy, and research. Exposures to radioactivity from the wastes are much smaller than those from natural sources, and federal standards limit public exposure. Currently operating disposal facilities are in Beatty, Nev, Barnwell, SC, and Richland, Wash. National policy encourages the development of regional facilities. Planning a regional facility, selecting a site, and building, monitoring, and closing the facility will be a complex project lasting decades that involves legislation, public participation, local and state governments, financing, quality control, and surveillance. The facilities will utilize geological factors, structural designs, packaging, and other approaches to isolate the wastes. Those providing medical care can reduce wastes by storing them until they are less radioactive, substituting nonradioactive compounds, reducing volumes, and incinerating. Physicians have an important role in informing and advising the public and public officials about risks involved with the wastes and about effective methods of dealing with them.

    19. Towards Small-Sized Long Tail Business with the Dual-Directed Recommendation System

      Science.gov (United States)

      Takahashi, Masakazu; Yamada, Takashi; Tsuda, Kazuhiko; Terano, Takao

      This paper describes a novel architecture to promote retail businesses using information recommendation systems. The main features of the architecture are 1) Dual-directed Recommendation system, 2) Portal site for three kinds of users: Producers, Retailers, and Consumers, which are considered to be Prosumers, and 3) Agent-based implementation. We have developed a web-based system DAIKOC (Dynamic Advisor for Information and Knowledge Oriented Communities) with the above architecture. In this paper, we focus on the recommendation functions to extract the items that will achieve the large sales in the future from the ID (IDentification)-POS (Point-Of-Sales) data.

    20. Intelligent Advisory System for Supporting University Managers in Law

      CERN Document Server

      Elalfi, Atta E E

      2009-01-01

      The rights and duties of both staff members and students are regulated by a large and different numbers of legal regulations and rules. This large number of rules and regulations makes the decision-making process time consuming and error boring. Smart advisory systems could provide rapid and accurate advices to managers and give the arguments for these advices. This paper presents an intelligent advisory system in law to assist the legal educational processes in universities and institutes. The aims of the system are: to provide smart legal advisors in the universities and institutes, to integrate rules and regulations of universities and institutes in the e-government, to ease the burden on the legal advisor and the provision of consulting services to users, to achieve accurate and timely presentation of the legal opinion to a given problem and to assure flexibility for accepting changes in the rules and legal regulations. The system is based on experienced jurists and the rules and regulations of the law or...

    1. Guidance Role of Advisor in the Subsequent Education of College Students Party Members%浅议辅导员在高校学生党员后续教育中的引导作用

      Institute of Scientific and Technical Information of China (English)

      蔡静; 钟敏; 鲍丽娟

      2012-01-01

        由于多元化社会价值观的冲击和大学生党员自身成长的需要,加强学生党员后续教育是非常必要的。同时,当今高校在大学生党建工作中普遍存在“重发展,轻教育”的现象,致使学生党员素质下降,特别是在党性修养和政治敏锐感等方面需要进一步加强教育和引导。辅导员作为一支高素质的政工干部队伍,在学生党员的后续教育中应当起到举足轻重的引导作用。%  Due to the impact of diverse social values ??and the need for growth of undergraduates’CCP members, it is necessary to strengthen the follow-up education of them. Meanwhile, it is a common phenomenon of"re-development and light follow-up education" in the construction work of universities, and the deterioration of the quality of undergraduates’party members is sharp. So it further needs to strengthen the education and guidance of the culture of party and sense of political acumen for undergraduates’party members. As a highly qualified team, advisors should play a pivotal role in guiding the follow-up education of undergraduates’party members.

    2. AN INTEGRATED PORTFOLIO AND ADVISING SYSTEM FOR UNDERGRADUATE ENGINEERING STUDENTS

      Directory of Open Access Journals (Sweden)

      EDWIN CHUNG

      2011-10-01

      Full Text Available Portfolios are important tools to document the professional experience of engineers, architects and other professionals. When implementing the portfolios at undergraduate level, often the quality of the portfolios’ entries and the frequency of their update by students are cited as obstacles. Other obstacles include the time consumed in assessing the portfolio and the timeliness of feedback given to students. To address these difficulties, an integrated Portfolio and Advising system was introduced at two modules offered at undergraduate engineering courses. The system requires the students to track the progress of their learning outcomes, provide documentary evidence to support claims of achievement of these learning outcomes and regularly meet their academic Advisors to seek feedback and validation of the achievement of the learning outcomes. This aimed at creating intentional learners out of these students as they take ownership of their academic progress. Feedback from both the students and the lecturers (Advisors is very encouraging as both students and lectures agreed that the system provides a useful and comprehensive tool to track the achievement of the module’s learning outcome.

    3. ¿Educadores, orientadores, terapeutas? Juventud, sexualidad e intervención social Educators, advisors, therapists? Youth, sexuality, and social intervention

      Directory of Open Access Journals (Sweden)

      Mara Viveros-Vigoya

      2006-01-01

      relationships with other agents of socialization of adolescents (fathers, mothers, educators, etc., but also with the public health system. In this field we identified the predominant perspectives of social intervention that seeks to direct and structure the possible field of action of youth in sexual matters. These perspectives emphasize individual responsibility in relation to self care and articulate very well with the effective model of health, based on market rationality.

    4. Structural characterization of an intestinal immune system-modulating arabino-3,6-galactan-like polysaccharide from the above-ground part of Astragalus membranaceus (Bunge).

      Science.gov (United States)

      Lim, Jung Dae; Yu, Chang Yeon; Kim, Seung Hyun; Chung, Ill Min

      2016-01-20

      Arabino-3,6-galactan (AMA-1-b-PS2), an intestinal immunomodulatory compound, was purified from the above-ground portion of Astragalus membranaceus (Bunge). Its structure was characterized using sequential enzymatic digestion with exo-α-L-arabinofuranosidase (AFase) and exo-β-D-(1 → 3)-galactanase (GNase), producing small amounts of intermediate-sized and shorter oligosaccharide (AF-PS2-G2 and AF-PS2-G3) fractions, and a large GNase-resistant fraction (AF-PS2-G1). Simultaneous AFase and GNase digestion of the enzyme-resistant fraction produced two long fragments (AF3-PS2-G1-1-1 and AF3-PS2-G1-1-2). Products of GNase digestion of the upper fractions showed decreased intestinal immunomodulatory activity; the GNase-resistant fraction (AF-PS2-G1) retained significant activity. Sugar component, methylation, and FAB-MS analyses indicated that the oligosaccharides consisted of hexosyl tri- to hexa-decasaccharides and hexosyl di- to hepta-saccharides mainly comprising 6-linked Gal(f) and Gal(p); some were partially mono- or di-arabinosylated. These oligosaccharide fractions were attached to the non-reducing terminus of the β-D-(1 → 3)-galactan backbone as side chains at position 6. AMA-1-b-PS2 likely modulates both the systemic and gastric mucosal immune systems.

    5. Isıtma Amaçlı Enerji Değişiminin Karabük İli İçin Araştırılması / A Research for Heating Energy Values in Karabuk Province

      Directory of Open Access Journals (Sweden)

      Mustafa ERTÜRK

      2012-12-01

      Full Text Available Bu çalışmada Devlet Meteoroloji Genel Müdürlüğü’nden temin edilen son otuz iki yılın meteorolojik veri seti kullanılmıştır. Bu veri seti ile Karabük ili ısıtma derece saat değerleri on bir farklı iç ortam referans sıcaklığına (18-28°C göre hesaplanmıştır. Karabük ili ısıtma derece saat değerleri baz alınarak seçilen iç ortam referans sıcaklığının 1-11°C üzerinde veya altında olması durumunda enerji talebindeki artışın veya azalmanın oransal olarak değişimi hesaplanmıştır. Bu çalışma konfor ortamını bozmadan iç ortam sıcaklığını yaşam alışkanlıklarımızda yapacağımız ufak düzenlemelerle çözmeyi amaçlamaktadır. Aile bütçesine, ülke ekonomisine, ülkenin enerji bağımlılığının azaltılmasına ve çevre-hava kirliliğinden dolayı oluşan küresel ısınmanın azaltılmasına önemli katkıda bulunacaktır. A Research for Heating Energy Values in Karabuk Province In this study, the data set of the past 32 years obtained from Turkish State Meteorological Services was used. With this data set, heating degree-hour values of Karabuk province were estimated according to eleven different indoor reference temperatures (18-28°C. The increase or the decrease in energy demand was estimated proportionally depending on the condition that the indoor reference temperature, which was selected based on the heating degree-hour values of Karabuk province, is above or below the range of 1-11°C. This study indicates that minor arrangements to be made pertaining to the indoor temperature without disturbing the comfort of the environment will make a significant contribution to reduce the global warming originating from environmental-air pollution as well as the energy dependency of our country.

    6. Hospitality Management: Perspectives from Industry Advisor

      Directory of Open Access Journals (Sweden)

      Rachel Roginsky

      2013-07-01

      Full Text Available In prior quarterly reports, Pinnacle Advisory Group presented timely updates about the New England lodging industry, which included focused profiles on particular cities. In this issue, the firm offers more general insight about the hospitality industry. Several Pinnacle executives recently participated in a panel discussion about investment, management, and careers in the hospitality industry.

    7. Meet Charles, big data query advisor

      NARCIS (Netherlands)

      Sellam, T.; Kersten, M.

      2013-01-01

      In scientific data management and business analytics, the most informative queries are a holy grail. Data collection becomes increasingly simpler, yet data exploration gets significantly harder. Exploratory querying is likely to return an empty or an overwhelming result set. On the other hand, data

    8. Meet Charles, big data query advisor

      NARCIS (Netherlands)

      Sellam, T.; Kersten, M.

      2013-01-01

      In scientific data management and business analytics, the most informative queries are a holy grail. Data collection becomes increasingly simpler, yet data exploration gets significantly harder. Exploratory querying is likely to return an empty or an overwhelming result set. On the other hand, data

    9. Advisor arrested on corruption charges / Matt Withers

      Index Scriptorium Estoniae

      Withers, Matt

      2008-01-01

      Tallinna abilinnapea nõunik Ivo Parbus vahistati kahtlustatuna pistise võtmises. Justiitsministeeriumi avalike suhete juhi Ivi Papsteli sõnul näitavad sagedased korruptsioonisüüdistused, et riik tegeleb korruptsioonivastase võitlusega

    10. 78 FR 67467 - Registration of Municipal Advisors

      Science.gov (United States)

      2013-11-12

      ... on municipal issuers requirements relating to governance, budgeting, accounting, and other financial... and pricing data for swap transactions. See 77 FR 1182 (January 9, 2012). Moreover, the Dodd- Frank... Commission and the public dissemination of security-based swap transaction, volume, and pricing information...

    11. Hospitality Management: Perspectives from Industry Advisor

      OpenAIRE

      Rachel Roginsky; Matthew Arrants

      2013-01-01

      In prior quarterly reports, Pinnacle Advisory Group presented timely updates about the New England lodging industry, which included focused profiles on particular cities. In this issue, the firm offers more general insight about the hospitality industry. Several Pinnacle executives recently participated in a panel discussion about investment, management, and careers in the hospitality industry.

    12. Peacetime Engagement: A Role for Military Advisors?

      Science.gov (United States)

      2000-01-01

      small num- ber of officers going to Pakistan, Bangladesh , Britain, and the United States. There are branch schools, but in-unit training is the norm...through direct deposits to bank accounts ■ improving health care for soldiers with simple preventive medicine (mosquito nets, hand-washing, and condoms

    13. Advisor arrested on corruption charges / Matt Withers

      Index Scriptorium Estoniae

      Withers, Matt

      2008-01-01

      Tallinna abilinnapea nõunik Ivo Parbus vahistati kahtlustatuna pistise võtmises. Justiitsministeeriumi avalike suhete juhi Ivi Papsteli sõnul näitavad sagedased korruptsioonisüüdistused, et riik tegeleb korruptsioonivastase võitlusega

    14. Konrad Adenauer’s Military Advisors

      Science.gov (United States)

      1989-02-13

      Ausgabe. Hans-Peter Schwarz and 45 Rudolf Morsey, Hg. Vol. 1, Briefe 1945-1947 hg. v. Hans Peter Mensing. Berlin: Siedler Verlag, 1983. Vol. 2, Briefe 1949...Dietrich, Rudolf Morsey and Hans-Peter Schwarz, ed. Quellen zur Geschichte des Parlarnentarismus und der politischen Partein. Bd. 3, Auftakt zur Ara...New York: Penguin, 1982. Steiner , Jirg. European Democracies. New York: Longman, 1986. Taylor, A.J.P. The Origens of the Second World War. 2d. ed. New

    15. So You Want to Be an Advisor

      Science.gov (United States)

      2006-04-01

      SPONSORING/ MONITORING AGENCY NAME(S) AND ADDRESS(ES) 10. SPONSOR/MONITOR’S ACRONYM(S) 11. SPONSOR/MONITOR’S REPORT NUMBER(S) 12. DISTRIBUTION...Football League’s kickers on the sidelines, practicing and practicing kicks into a net. On summer days in Major League baseball, throw- ing “on the side

    16. Design, Analysis and Implementation of the Primary Operation, RETRIEVE-COMMON, of the Multi-Backend Database System (MBDS).

      Science.gov (United States)

      1985-06-01

      Hsiang -lung Tung 2 8 lane 46 Ming- Chuan Road Ctia-i CiLty Taiwan 600 Pepublic of 6hina tit 148 •, 1,,J., ., FILMED 4.~ 0-85 DTIC p.0 ...DATABASE SYSTEM (MBDS) by ~i. Hsiang -Lung Tung June 1985 Thesis Advisor: David K. Hsiao -’-" Approved for public release; distribution is unlimited P- A...Desi n. Analysis and Implementation of the grimazy operation Retriee-Coamon of the Rulti-BAckbnd Datafase System (MBDS by Hsiang -Lung Tung

    17. The importance of input variables to a neural network fault-diagnostic system for nuclear power plants

      Energy Technology Data Exchange (ETDEWEB)

      Lanc, T.L.

      1992-12-31

      This thesis explores safety enhancement for nuclear power plants. Emergency response systems currently in use depend mainly on automatic systems engaging when certain parameters go beyond a pre-specified safety limit. Often times the operator has little or no opportunity to react since a fast scram signal shuts down the reactor smoothly and efficiently. These accidents are of interest to technical support personnel since examining the conditions that gave rise to these situations help determine causality. In many other cases an automated fault-diagnostic advisor would be a valuable tool in assisting the technicians and operators to determine what just happened and why.

    18. The importance of input variables to a neural network fault-diagnostic system for nuclear power plants

      Energy Technology Data Exchange (ETDEWEB)

      Lanc, T.L.

      1992-01-01

      This thesis explores safety enhancement for nuclear power plants. Emergency response systems currently in use depend mainly on automatic systems engaging when certain parameters go beyond a pre-specified safety limit. Often times the operator has little or no opportunity to react since a fast scram signal shuts down the reactor smoothly and efficiently. These accidents are of interest to technical support personnel since examining the conditions that gave rise to these situations help determine causality. In many other cases an automated fault-diagnostic advisor would be a valuable tool in assisting the technicians and operators to determine what just happened and why.

    19. Intrusion Deception in Defense of Computer Systems

      Science.gov (United States)

      2007-03-01

      Goh March 2007 Thesis Advisor: Neil C. Rowe Second Reader: Daniel F . Warren Approved for public release; distribution is unlimited...the NAVAL POSTGRADUATE SCHOOL March 2007 Author: Han Chong Goh Approved by: Neil C. Rowe Thesis Advisor Daniel F . Warren

    20. A Generic Adaptive Method for Corruption Mitigation in Trial Monitoring System with Restful Authorization

      Directory of Open Access Journals (Sweden)

      Suryanaraayan.B1 , Subramanian.M2 , Saikrishna.K.K3 , Sujitha.G4

      2015-10-01

      Full Text Available The purpose of a Trial Monitoring System is to provide a comprehensive suite where cases are created. Trial proceedings are monitored progressively to make informed decisions that include assignment of investigating entities and requesting advisors for opinions to take over the prosecution of the case. It provides a platform for applying counter petitions against an allegation's disposal and integrate proceedings in different levels of scrutiny and across tribunal entities. The outcome is the aggregation of such a data, to classify cases for statistical information and relaying the information in presentable format.

    1. systems

      Directory of Open Access Journals (Sweden)

      Alexander Leonessa

      2000-01-01

      Full Text Available A nonlinear robust control-system design framework predicated on a hierarchical switching controller architecture parameterized over a set of moving nominal system equilibria is developed. Specifically, using equilibria-dependent Lyapunov functions, a hierarchical nonlinear robust control strategy is developed that robustly stabilizes a given nonlinear system over a prescribed range of system uncertainty by robustly stabilizing a collection of nonlinear controlled uncertain subsystems. The robust switching nonlinear controller architecture is designed based on a generalized (lower semicontinuous Lyapunov function obtained by minimizing a potential function over a given switching set induced by the parameterized nominal system equilibria. The proposed framework robustly stabilizes a compact positively invariant set of a given nonlinear uncertain dynamical system with structured parametric uncertainty. Finally, the efficacy of the proposed approach is demonstrated on a jet engine propulsion control problem with uncertain pressure-flow map data.

    2. „Ert ekki slæmur fyrr en þú færð slæmt“: Viðhorf og viðbrögð veitingastaða við TripAdvisor

      OpenAIRE

      Kristinn Jaferian 1991

      2016-01-01

      Undanfarin ár hafa samfélagsmiðlar skipað stóran sess í lífi fólks. Hver samfélagsmiðill hefur sinn tilgang en oft á tíðum notar fólk miðlana vegna hentugleika hvort sem miðillinn er hannaður til að auðvelda samskipti við kunningja eða sem upplýsingaveita. Í þessari rannsókn er samfélagsmiðillinn TripAdvisor til umfjöllunnar og gert verður grein fyrir þeim áhrifum sem miðillinn hefur haft í för með sér. Tilgangur rannsóknarinnar var að kanna viðhorf stjórnenda veitingastaða til TripAdvisor...

    3. [Certified occupational physician system of Japan Society for Occupational Health].

      Science.gov (United States)

      Ogami, Akira; Higashi, Toshiaki

      2013-10-01

      Certified Occupational Physician System (COPS) of Japan Society for Occupational Health has been in existence for 21 years, since 1992. UOEH has supported this system as a secretary general. In this report, we review the 2012 revision of COPS. With the new title of Certified Associate Occupational Physician (CAOP), this revision was established to produce well-educated and experienced occupational physicians. The title of COP is not competitive but independent to other titles such as occupational physician, medical advisor in industrial health or industrial health consultant. In addition, the aim of COPS is not the replacement to these existing systems. Furthermore, the COP should be active in industrial and occupational health, and should cooperate with existing systems through the sharing of experience and knowledge.

    4. Dégradation des écosystèmes steppiques et stratégie de développement durable. Mise au point méthodologique appliquée à la Wilaya de Nâama (Algérie

      Directory of Open Access Journals (Sweden)

      Arslan A. Bouchetata

      2005-09-01

      Full Text Available Le désert avance dangereusement… inexorablement du Sud vers le Nord. Un diagnostic écologique récent (2000, réalisé le long d’un transect Nord – Sud de la zone steppique à l’Ouest du territoire algérien (Wilaya de Nâama, l’a établi. Un diagnostic plus récent (2003 réalisé dans la même zone, une centaine de Km à l’Est, l’a confirmé. Une approche diachronique fondée sur la comparaison des relevés de 2000 avec les unités physionomiques des cartes pastorales de l’Algérie éditées par le CRBT en 1980, indique qu’en l’espace de 20 ans deux espèces caractéristiques de cette zone comme Stipa tenacissima et Artemisia herba alba ont perdu une grande partie de leur territoire. Dans certains espaces, elles ont complètement disparu. Les approches technicistes et fragmentaires, et la planification centralisée technico–administrative, accompagnés localement de comportements tenant insuffisamment compte de la fragilité de l’écosystème ont abouti à l’extension d’actions écologiquement néfastes : défrichement inconsidéré, surpâturage, abandon… dont les effets négatifs ont été aggravés par de longues périodes de sécheresse. Pourtant, des méthodes et techniques de protection et de régénération des parcours peuvent être utilisées dans le cadre de programmes d’aménagement pertinents engageant pleinement les populations locales directement concernées : réduction de la charge animale, rotation des pacages, mise en défens, resemis des parcours dégradés, plantation d’arbustes fourragers…L’utilisation d’une méthodologie appropriée fondée sur l’approche participative et la planification par objectifs semble être un moyen efficace pour une planification adaptée afin d’atteindre un développement durable dans le territoire steppique. En application de cette démarche, nous avons procédé à l’élaboration d’un « arbre des problèmes » qui a permis l

    5. Evaluation of the Field of Listening / Watching of Goals and Objectives Dimension in Turkish Language Teaching Curriculum According to Teachers’ Views / Türkçe Dersi Öğretim Programı Dinleme / İzleme Alanı Amaç ve Kazanımlar Boyutunun Öğretmen Görüşleri Doğrultusunda Değerlendirilmesi

      Directory of Open Access Journals (Sweden)

      Faruk YILDIRIM

      2013-06-01

      Full Text Available The aim of this study was to evaluate according to goals and objectives dimension of listening/watching domain in 8th grade Turkish Language Curriculum based on teachers’ views. This study was a descriptive study based on survey model and qualitative research was designed according to the method. Population of the study was composed of Turkish Language teachers teaching 8th graders in public and private schools in Kars city center. For qualitative data, 15 Turkish Language teachers were selected through convenient sampling method and they were interviewed. Quantitative data were gathered through “Evaluation of Listening/Watching Domain of 8th Grade Turkish Language Curriculum Questionnaire” which was developed by the researcher, and qualitative data were gathered through semi-structured interview form. Qualitative data gathered with interview, then, were analyzed with content analysis method. As a result of Listening/watching’s goals and objectives of 8th grade Turkish Language Curriculum is adequate according to Turkish language teachers. Bu araştırmanın amacı, sekizinci sınıf Türkçe Dersi Öğretim Programı (TDÖP Dinleme / İzleme alanına yönelik amaç ve kazanımları öğretmen görüşleri doğrultusunda değerlendirmektir. Araştırma tarama modelinde betimsel bir çalışmadır ve nitel yönteme göre desenlenmiştir. Araştırma evrenini Kars ilindeki resmî ve özel ilköğretim okullarında görev yapan ve sekizinci sınıflarda Türkçe derslerini yürüten branş öğretmenleri oluşturmaktadır. Araştırmada nitel verileri elde etmek için kolay ulaşılabilir durum örneklemesi kullanılmış ve 15 Türkçe öğretmeni ile görüşme yapılmıştır. Nitel veriler yarı yapılandırılmış görüşme formu kullanılarak toplanmıştır. Yapılan görüşmeler sonucunda elde edilen nitel verilerin analiz edilmesinde içerik analizi tekniği kullanılmıştır. Araştırma sonucunda Türkçe öğretmenleri ama

    6. Parameter design and performance simulation of electric automotive transmission system based on ADVISOR%基于ADVISOR的电动汽车传动系统参数设计与性能仿真

      Institute of Scientific and Technical Information of China (English)

      方锡邦; 王方

      2011-01-01

      对电动汽车电动机、传动系的传动比和电池组容量等参数设计的原则和方法进行了研究,以某种型号电动汽车为研究对象,对其动力传动系的参数进行合理的选择和设计.建立了整车动力传动系统的仿真模型,应用电动汽车仿真软件ADVISOR对整车动力性进行了仿真计算.仿真结果表明,以铅酸电池为能源的电动汽车的加速性、爬坡能力、最大车速、续驶里程等动力性能均满足设计指标要求,设计的动力传动系的参数能够确保整车动力性能达到相应的技术要求.从而验证了文中的传动系统参数选择的正确性.

    7. Simulation and Characteristics Analysis of the Automotive 48 V Power System Based on ADVISOR%基于ADVISOR的汽车48V动力系统仿真及特性分析

      Institute of Scientific and Technical Information of China (English)

      周夏威; 朱昌吉; 曲大为

      2014-01-01

      随着汽车新技术的快速发展和新电子元件、半导体的广泛应用,汽车上电能的消耗量不断增加,使得传统的12 V电源无法输出所需的功率.介绍了汽车新型48 V电源总线架构,应用ADVISOR软件对汽车48 V动力系统进行建模仿真,对其仿真结果进行特性分析,并与相同配置的传统车进行对比分析.结果表明,汽车48 V动力系统能实现减小油耗、降低排放和节能的目标.

    8. Influence of commonly used clinical antidotes on antioxidant systems in human hepatocyte culture intoxicated with alpha-amanitin.

      Science.gov (United States)

      Magdalan, Jan; Piotrowska, Aleksandra; Gomułkiewicz, Agnieszka; Sozański, Tomasz; Szeląg, Adam; Dziegięl, Piotr

      2011-01-01

      α-Amanitin (α-AMA) is the main toxin of Amanita phalloides and its subspecies (A. virosa and A. verna). The primary mechanism of α-AMA toxicity is associated with protein synthesis blocking in hepatocytes. Additionally, α-AMA exhibits prooxidant properties that may contribute to its severe hepatotoxicity. The aim of the present study was to assess the effect of α-AMA on lipid peroxidation and the activities of superoxide dismutase (SOD) and catalase (CAT) in human hepatocyte culture. The effects of benzylpenicillin (BPCN), N-acetyl-L-cysteine (ACC), and silibinin (SIL) on SOD and CAT activities and on lipid peroxidation in human hepatocyte culture intoxicated with α-AMA were also examined. In human hepatocyte culture, 48-hour exposure to α-AMA at a 2-μM concentration caused an increase in SOD activity, a reduction of CAT activity, and a significant increase in lipid peroxidation. Changes in SOD and CAT activity caused by α-AMA could probably enhance lipid peroxidation by increased generation of hydrogen peroxide combined with reduced detoxification of that oxygen radical. The addition of antidotes (ACC or SIL) to the culture medium provided more effective protection against lipid peroxidation in human hepatocytes intoxicated with α-AMA than the addition of BPCN, possessing no antioxidant properties.

    9. On the development of an expert system for wheelchair selection

      Science.gov (United States)

      Madey, Gregory R.; Bhansin, Charlotte A.; Alaraini, Sulaiman A.; Nour, Mohamed A.

      1994-01-01

      The presentation of wheelchairs for the Multiple Sclerosis (MS) patients involves the examination of a number of complicated factors including ambulation status, length of diagnosis, and funding sources, to name a few. Consequently, only a few experts exist in this area. To aid medical therapists with the wheelchair selection decision, a prototype medical expert system (ES) was developed. This paper describes and discusses the steps of designing and developing the system, the experiences of the authors, and the lessons learned from working on this project. Wheelchair Advisor, programmed in CLIPS, serves as diagnosis, classification, prescription, and training tool in the MS field. Interviews, insurance letters, forms, and prototyping were used to gain knowledge regarding the wheelchair selection problem. Among the lessons learned are that evolutionary prototyping is superior to the conventional system development life-cycle (SDLC), the wheelchair selection is a good candidate for ES applications, and that ES can be applied to other similar medical subdomains.

    10. A novel pen-based Bluetooth-enabled insulin delivery system with insulin dose tracking and advice.

      Science.gov (United States)

      Bailey, Timothy S; Stone, Jenine Y

      2017-05-01

      Diabetes is growing in prevalence internationally. As more individuals require insulin as part of their treatment, technology evolves to optimize delivery, improve adherence, and reduce dosing errors. Insulin pens outperform vial and syringe in simplicity, dosing accuracy, and user preference. Bolus advisors improve dosing confidence and treatment adherence. The InPen System offers a novel approach to treatment via a wireless pen that syncs to a mobile application featuring a bolus advisor, enabling convenient insulin dose tracking and more accurate bolus advice among other features. Areas covered: Existing technology for insulin delivery and bolus advice are reviewed. The mechanics and functionality of the InPen device are delineated. Findings from formative testing and usability studies of the InPen system are reported. Future directions for the InPen system in the treatment of diabetes are discussed. Expert opinion: Diabetes management is complex and largely data-driven. The InPen System offers a promising new opportunity to avail insulin pen-users of features known to improve treatment efficacy, which have otherwise primarily been available to those using pumps. Given that the majority of insulin users do not use insulin pumps, the InPen System is poised to improve glucose control in a significant portion of the diabetes population.

    11. Analyzing the impact of shading on photovoltaic arrays to optimize system effectiveness

      Energy Technology Data Exchange (ETDEWEB)

      Ho Jo, Jin; Kennell, Dave; Richey, Steve [Illinois State University (United States)], e-mail: jjo@ilstu.edu, email: drkennell@ilstu.edu, email: spriche@ilstu.edu

      2011-07-01

      The empirical and simulation modeling analyses of the impact of partial shading on a photovoltaic array by rooftop objects, e.g. HVAC equipment, is reported in this paper to determine optimized system capacity, configuration and orientation. In this study, a design approach that can be applied to determine both the appropriate area for photovoltaic system installation and the system capacity that optimizes the overall performance of the photovoltaic system is proposed. On-site data collection from the installed photovoltaic system was compared with a renewable energy computer simulation, the System Advisor Model, developed by the National Renewable Energy Laboratory, which has been used to examine the potential effects of different application options and suggest optimized array designs to maximize energy production and boost return-on-investment throughout the year. It was found that partial shading may not have a significant impact on the annual electrical output and can be tolerable within a certain range.

    12. How Can Medical Students Add Value? Identifying Roles, Barriers, and Strategies to Advance the Value of Undergraduate Medical Education to Patient Care and the Health System.

      Science.gov (United States)

      Gonzalo, Jed D; Dekhtyar, Michael; Hawkins, Richard E; Wolpaw, Daniel R

      2017-09-01

      As health systems evolve, the education community is seeking to reimagine student roles that combine learning with meaningful contributions to patient care. The authors sought to identify potential stakeholders regarding the value of student work, and roles and tasks students could perform to add value to the health system, including key barriers and associated strategies to promote value-added roles in undergraduate medical education. In 2016, 32 U.S. medical schools in the American Medical Association's (AMA's) Accelerating Change in Education Consortium met for a two-day national meeting to explore value-added medical education; 121 educators, systems leaders, clinical mentors, AMA staff leadership and advisory board members, and medical students were included. A thematic qualitative analysis of workshop discussions and written responses was performed, which extracted key themes. In current clinical roles, students can enhance value by performing detailed patient histories to identify social determinants of health and care barriers, providing evidence-based medicine contributions at the point-of-care, and undertaking health system research projects. Novel value-added roles include students serving as patient navigators/health coaches, care transition facilitators, population health managers, and quality improvement team extenders. Six priority areas for advancing value-added roles are student engagement, skills, and assessments; balance of service versus learning; resources, logistics, and supervision; productivity/billing pressures; current health systems design and culture; and faculty factors. These findings provide a starting point for collaborative work to positively impact clinical care and medical education through the enhanced integration of value-added medical student roles into care delivery systems.

    13. systems

      Directory of Open Access Journals (Sweden)

      Patrick L. Brockett

      1978-01-01

      Full Text Available Suppose S={{Xnj,   j=1,2,…,kn}} is an infinitesimal system of random variables whose centered sums converge in law to a (necessarily infinitely divisible distribution with Levy representation determined by the triple (γ,σ2,M. If {Yj,   j=1,2,…} are independent indentically distributed random variables independent of S, then the system S′={{YjXnj,j=1,2,…,kn}} is obtained by randomizing the scale parameters in S according to the distribution of Y1. We give sufficient conditions on the distribution of Y in terms of an index of convergence of S, to insure that centered sums from S′ be convergent. If such sums converge to a distribution determined by (γ′,(σ′2,Λ, then the exact relationship between (γ,σ2,M and (γ′,(σ′2,Λ is established. Also investigated is when limit distributions from S and S′ are of the same type, and conditions insuring products of random variables belong to the domain of attraction of a stable law.

    14. system

      Science.gov (United States)

      Garcilazo, H.; Valcarce, A.; Vijande, J.

      2017-07-01

      Using local central Yukawa-type Malfliet-Tjon interactions reproducing the low-energy parameters and phase shifts of the nn system, and the latest updates of the nΛ and ΛΛ Nijmegen ESC08c potentials, we study the possible existence of a bound state. Our results indicate that the is unbound, being just above threshold. We discuss the role played by the 1 S 0 nn repulsive term of the Yukawa-type Malfliet-Tjon interaction. Supported by COFAA-IPN (México), Ministerio de Economía, Industria y Competitividad and EU FEDER (FPA2013-47443, FPA2015-69714-REDT, FPA2016-77177), Junta de Castilla y León (SA041U16) and Generalitat Valenciana PrometeoII/2014/066

    15. SYSTEM

      Directory of Open Access Journals (Sweden)

      K. Swarnalatha

      2013-01-01

      Full Text Available Risk analysis of urban aquatic systems due to heavy metals turns significant due to their peculiar properties viz. persis tence, non-degradab ility, toxicity, and accumulation. Akkulam Veli (AV, an urba n tropical lake in south India is subjected to various environmental stresses due to multiple waste discharge, sand mining, developmental activities, tour ism related activitie s etc. Hence, a comprehensive approach is adopted for risk assessment using modified degree of contamination factor, toxicity units based on numerical sediment quality guidelines (SQGs, and potentialecological risk indices. The study revealed the presence of toxic metals such as Cr, C d, Pb and As and the lake is rated under ‘low ecological risk’ category.

    16. 75 FR 26815 - AdvisorShares Investments, LLC and AdvisorShares Trust; Notice of Application

      Science.gov (United States)

      2010-05-12

      ... investment objective by utilizing an ``active'' management strategy. Funds may invest in equity securities or... and not in any other registered investment company. \\2\\ Depositary Receipts include ADRs and Global...-managed exchange- traded fund.'' All marketing materials that describe the features or method of...

    17. 电动汽车仿真软件ADVISOR%Electric Vehicles Simulation Software ADVISOR

      Institute of Scientific and Technical Information of China (English)

      张翔; 赵韩; 钱立军; 张炳力

      2003-01-01

      分析了美国电动汽车仿真软件ADVISOR的系统功能,ADVISOR可以仿真传统汽车、电动汽车、燃料电池汽车和混合动力汽车等多种汽车的性能,并且能与其它多种软件共同仿真.本文对我国开发自己的电动汽车仿真软件具有参考作用.

    18. 78 FR 11702 - AdvisorShares Investments, LLC and AdvisorShares Trust; Notice of Application

      Science.gov (United States)

      2013-02-19

      ..., LLC, Pring Turner Capital Group, Newfleet Asset Management, LLC, and Treesdale Partners LLC. 4... statement and shareholder reports filed with the Commission. Sections 6-07(2)(a), (b) and (c) of Regulation... majority of the Fund's outstanding voting securities, as defined in the Act, or, in the case of a...

    19. Design of an Efficient Integrated System for Ambulance Management

      Directory of Open Access Journals (Sweden)

      Raid S. Sarhan

      2015-08-01

      Full Text Available Because the increases in accidents and emergencies require less time and faster access whenever possible in order to reduce the chances of death, This study designed an ambulance management system (AMaSy which utilize GIS, GPS, and GPRS that was tested in principle in Al-Mansoura City - EGYPT. The proposed system takes into consideration the emergency cases that could possibly occur. The research work considers all possible cases. While an ambulance could already be occupied with one patient, the system considers it as an available ambulance and requests it for another case, being that the ambulance only needs a short period of time to drop-off the current case and that the second case is relatively close to the ambulance. This forces the ambulance to quicken the processes of drop-off and pick-up between the two cases. The main objective of this research work is to make an ambulance system which enables ambulances to have faster arrivals and take less time to reach accident sites

    20. A development process meta-model for Web based expert systems: The Web engineering point of view

      DEFF Research Database (Denmark)

      Dokas, I.M.; Alapetite, Alexandre

      2006-01-01

      Similar to many legacy computer systems, expert systems can be accessed via the Web, forming a set of Web applications known as Web based expert systems. The tough Web competition, the way people and organizations rely on Web applications and theincreasing user requirements for better services have...... raised their complexity. Unfortunately, there is so far no clear answer to the question: How may the methods and experience of Web engineering and expert systems be combined and applied in order todevelop effective and successful Web based expert systems? In an attempt to answer this question......, a development process meta-model for Web based expert systems will be presented. Based on this meta-model, a publicly available Web based expert systemcalled Landfill Operation Management Advisor (LOMA) was developed. In addition, the results of an accessibility evaluation on LOMA – the first ever reported...