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Sample records for advanced integrated solvent

  1. Advanced integrated solvent extraction systems

    Energy Technology Data Exchange (ETDEWEB)

    Horwitz, E.P.; Dietz, M.L.; Leonard, R.A. [Argonne National Lab., IL (United States)

    1997-10-01

    Advanced integrated solvent extraction systems are a series of novel solvent extraction (SX) processes that will remove and recover all of the major radioisotopes from acidic-dissolved sludge or other acidic high-level wastes. The major focus of this effort during the last 2 years has been the development of a combined cesium-strontium extraction/recovery process, the Combined CSEX-SREX Process. The Combined CSEX-SREX Process relies on a mixture of a strontium-selective macrocyclic polyether and a novel cesium-selective extractant based on dibenzo 18-crown-6. The process offers several potential advantages over possible alternatives in a chemical processing scheme for high-level waste treatment. First, if the process is applied as the first step in chemical pretreatment, the radiation level for all subsequent processing steps (e.g., transuranic extraction/recovery, or TRUEX) will be significantly reduced. Thus, less costly shielding would be required. The second advantage of the Combined CSEX-SREX Process is that the recovered Cs-Sr fraction is non-transuranic, and therefore will decay to low-level waste after only a few hundred years. Finally, combining individual processes into a single process will reduce the amount of equipment required to pretreat the waste and therefore reduce the size and cost of the waste processing facility. In an ongoing collaboration with Lockheed Martin Idaho Technology Company (LMITCO), the authors have successfully tested various segments of the Advanced Integrated Solvent Extraction Systems. Eichrom Industries, Inc. (Darien, IL) synthesizes and markets the Sr extractant and can supply the Cs extractant on a limited basis. Plans are under way to perform a test of the Combined CSEX-SREX Process with real waste at LMITCO in the near future.

  2. Advanced integrated solvent extraction and ion exchange systems

    Energy Technology Data Exchange (ETDEWEB)

    Horwitz, P. [Argonne National Lab., IL (United States)

    1996-10-01

    Advanced integrated solvent extraction (SX) and ion exchange (IX) systems are a series of novel SX and IX processes that extract and recover uranium and transuranics (TRUs) (neptunium, plutonium, americium) and fission products {sup 90}Sr, {sup 99}Tc, and {sup 137}Cs from acidic high-level liquid waste and that sorb and recover {sup 90}Sr, {sup 99}Tc, and {sup 137}Cs from alkaline supernatant high-level waste. Each system is based on the use of new selective liquid extractants or chromatographic materials. The purpose of the integrated SX and IX processes is to minimize the quantity of waste that must be vitrified and buried in a deep geologic repository by producing raffinates (from SX) and effluent streams (from IX) that will meet the specifications of Class A low-level waste.

  3. Advanced Amine Solvent Formulations and Process Integration for Near-Term CO2 Capture Success

    Energy Technology Data Exchange (ETDEWEB)

    Fisher, Kevin S.; Searcy, Katherine; Rochelle, Gary T.; Ziaii, Sepideh; Schubert, Craig

    2007-06-28

    This Phase I SBIR project investigated the economic and technical feasibility of advanced amine scrubbing systems for post-combustion CO2 capture at coal-fired power plants. Numerous combinations of advanced solvent formulations and process configurations were screened for energy requirements, and three cases were selected for detailed analysis: a monoethanolamine (MEA) base case and two “advanced” cases: an MEA/Piperazine (PZ) case, and a methyldiethanolamine (MDEA) / PZ case. The MEA/PZ and MDEA/PZ cases employed an advanced “double matrix” stripper configuration. The basis for calculations was a model plant with a gross capacity of 500 MWe. Results indicated that CO2 capture increased the base cost of electricity from 5 cents/kWh to 10.7 c/kWh for the MEA base case, 10.1 c/kWh for the MEA / PZ double matrix, and 9.7 c/kWh for the MDEA / PZ double matrix. The corresponding cost per metric tonne CO2 avoided was 67.20 $/tonne CO2, 60.19 $/tonne CO2, and 55.05 $/tonne CO2, respectively. Derated capacities, including base plant auxiliary load of 29 MWe, were 339 MWe for the base case, 356 MWe for the MEA/PZ double matrix, and 378 MWe for the MDEA / PZ double matrix. When compared to the base case, systems employing advanced solvent formulations and process configurations were estimated to reduce reboiler steam requirements by 20 to 44%, to reduce derating due to CO2 capture by 13 to 30%, and to reduce the cost of CO2 avoided by 10 to 18%. These results demonstrate the potential for significant improvements in the overall economics of CO2 capture via advanced solvent formulations and process configurations.

  4. Advances in integrated optics

    CERN Document Server

    Chester, A; Bertolotti, M

    1994-01-01

    This volwne contains the Proceedings of a two-week summer conference titled "Advances in Integrated Optics" held June 1-9, 1993, in Erice, Sicily. This was the 18th annual course organized by the International School of Quantum Electronics, under the auspices of the "Ettore Majorana" Centre for Scientific Culture. The term Integrated Optics signifies guided-wave optical circuits consisting of two or more devices on a single substrate. Since its inception in the late 1960's, Integrated Optics has evolved from a specialized research topic into a broad field of work, ranging from basic research through commercial applications. Today many devices are available on market while a big effort is devolved to research on integrated nonlinear optical devices. This conference was organized to provide a comprehensive survey of the frontiers of this technology, including fundamental concepts, nonlinear optical materials, devices both in the linear and nonlinear regimes, and selected applications. These Proceedings update a...

  5. Advanced Integrated Traction System

    Energy Technology Data Exchange (ETDEWEB)

    Greg Smith; Charles Gough

    2011-08-31

    The United States Department of Energy elaborates the compelling need for a commercialized competitively priced electric traction drive system to proliferate the acceptance of HEVs, PHEVs, and FCVs in the market. The desired end result is a technically and commercially verified integrated ETS (Electric Traction System) product design that can be manufactured and distributed through a broad network of competitive suppliers to all auto manufacturers. The objectives of this FCVT program are to develop advanced technologies for an integrated ETS capable of 55kW peak power for 18 seconds and 30kW of continuous power. Additionally, to accommodate a variety of automotive platforms the ETS design should be scalable to 120kW peak power for 18 seconds and 65kW of continuous power. The ETS (exclusive of the DC/DC Converter) is to cost no more than $660 (55kW at $12/kW) to produce in quantities of 100,000 units per year, should have a total weight less than 46kg, and have a volume less than 16 liters. The cost target for the optional Bi-Directional DC/DC Converter is $375. The goal is to achieve these targets with the use of engine coolant at a nominal temperature of 105C. The system efficiency should exceed 90% at 20% of rated torque over 10% to 100% of maximum speed. The nominal operating system voltage is to be 325V, with consideration for higher voltages. This project investigated a wide range of technologies, including ETS topologies, components, and interconnects. Each technology and its validity for automotive use were verified and then these technologies were integrated into a high temperature ETS design that would support a wide variety of applications (fuel cell, hybrids, electrics, and plug-ins). This ETS met all the DOE 2010 objectives of cost, weight, volume and efficiency, and the specific power and power density 2015 objectives. Additionally a bi-directional converter was developed that provides charging and electric power take-off which is the first step

  6. Solvent

    OpenAIRE

    Hamida Y. Mostafa; Ebaa A. El-Shamy; Amal S. Farag; Nadia G. Kandile

    2013-01-01

    Neat ethylacetoacetate (EAA) and its mixtures with a co-solvent and an anti-solvent have been studied for refining of heavy wax distillate fraction to produce substantially non-carcinogenic base oil. The co-solvent and anti-solvent used are dipropylene glycol (DPG) and ethylene glycol (EG) respectively. The solubility characteristics of the main solvent and its mixed solvent systems were studied. Selection of the optimum solvent mixture and extraction variables has been studied. The effect of...

  7. Recent Advances in Anhydrous Solvents for CO2 Capture: Ionic Liquids, Switchable Solvents, and Nanoparticle Organic Hybrid Materials

    Directory of Open Access Journals (Sweden)

    YOUNGJUNE ePARK

    2015-10-01

    Full Text Available CO2 capture by amine scrubbing, which has a high CO2 capture capacity and a rapid reaction rate, is the most employed and investigated approach to date. There are a number of recent large-scale demonstrations including the Boundary Dam Carbon Capture Project by SaskPower in Canada that have reported successful implementations of aqueous amine solvent in CO2 capture from flue gases. The findings from these demonstrations will significantly advance the field of CO2 capture in the coming years. While the latest efforts in aqueous amine solvents are exciting and promising, there are still several drawbacks to amine-based CO2 capture solvents including high volatility and corrosiveness of the amine solutions, as well as the high parasitic energy penalty during the solvent regeneration step. Thus, in a parallel effort, alternative CO2 capture solvents, which are often anhydrous, have been developed as the third-generation CO2 capture solvents. These novel classes of liquid materials include: Ionic Liquids (ILs, CO2-triggered switchable solvents (i.e., CO2 Binding Organic Liquids (CO2BOLs, Reversible Ionic Liquids (RevILs, and Nanoparticle Organic Hybrid Materials (NOHMs. This paper provides a review of these various anhydrous solvents and their potential for CO2 capture. Particular attention is given to the mechanisms of CO2 absorption in these solvents, their regeneration and their processability – especially taking into account their viscosity. While not intended to provide a complete coverage of the existing literature, this review aims at pointing the major findings reported for these new classes of CO2 capture media.

  8. Advanced integrated enhanced vision systems

    Science.gov (United States)

    Kerr, J. R.; Luk, Chiu H.; Hammerstrom, Dan; Pavel, Misha

    2003-09-01

    In anticipation of its ultimate role in transport, business and rotary wing aircraft, we clarify the role of Enhanced Vision Systems (EVS): how the output data will be utilized, appropriate architecture for total avionics integration, pilot and control interfaces, and operational utilization. Ground-map (database) correlation is critical, and we suggest that "synthetic vision" is simply a subset of the monitor/guidance interface issue. The core of integrated EVS is its sensor processor. In order to approximate optimal, Bayesian multi-sensor fusion and ground correlation functionality in real time, we are developing a neural net approach utilizing human visual pathway and self-organizing, associative-engine processing. In addition to EVS/SVS imagery, outputs will include sensor-based navigation and attitude signals as well as hazard detection. A system architecture is described, encompassing an all-weather sensor suite; advanced processing technology; intertial, GPS and other avionics inputs; and pilot and machine interfaces. Issues of total-system accuracy and integrity are addressed, as well as flight operational aspects relating to both civil certification and military applications in IMC.

  9. Advanced optical manufacturing digital integrated system

    Science.gov (United States)

    Tao, Yizheng; Li, Xinglan; Li, Wei; Tang, Dingyong

    2012-10-01

    It is necessarily to adapt development of advanced optical manufacturing technology with modern science technology development. To solved these problems which low of ration, ratio of finished product, repetition, consistent in big size and high precision in advanced optical component manufacturing. Applied business driven and method of Rational Unified Process, this paper has researched advanced optical manufacturing process flow, requirement of Advanced Optical Manufacturing integrated System, and put forward architecture and key technology of it. Designed Optical component core and Manufacturing process driven of Advanced Optical Manufacturing Digital Integrated System. the result displayed effective well, realized dynamic planning Manufacturing process, information integration improved ratio of production manufactory.

  10. Recent Advances in Anhydrous Solvents for CO2 Capture: Ionic Liquids, Switchable Solvents, and Nanoparticle Organic Hybrid Materials

    OpenAIRE

    YOUNGJUNE ePARK; Kun-Yi Andrew eLin; Ah-Hyung Alissa Park; Camille ePetit

    2015-01-01

    CO2 capture by amine scrubbing, which has a high CO2 capture capacity and a rapid reaction rate, is the most employed and investigated approach to date. There are a number of recent large-scale demonstrations including the Boundary Dam Carbon Capture Project by SaskPower in Canada that have reported successful implementations of aqueous amine solvent in CO2 capture from flue gases. The findings from these demonstrations will significantly advance the field of CO2 capture in the coming years. ...

  11. Advanced Microgravity Compatible, Integrated Laundry System Project

    Data.gov (United States)

    National Aeronautics and Space Administration — An Advanced Microgravity Compatible, Integrated laundry System (AMCILS) is proposed that uses a two phase water / water vapor system to allow good agitation of...

  12. Integration of process and solvent design towards a novel generation of CO2 absorption capture systems

    NARCIS (Netherlands)

    Oyarzun, B.A.; Bardow, A.; Gross, J.

    2011-01-01

    A method for the integrated process and solvent design of absorption separation systems is proposed in this work. The method is employed here to improve the energetic performance of a pre-combustion CO2 absorption capture process by simultaneous optimization of process and solvent variables. In the

  13. Advanced Integrated Power Systems (AIPS)

    Science.gov (United States)

    2012-10-08

    microgrid environment. Fault current distribution during islanded and grid-connected operation was the primary issue investigated. Their paper...describes an earthing or grounding system design for integration into a microgrid . Their design would rely on over current sensing technologies that are...were compared to actual data to verify the validity of the model. The model can now be used with microgrid models to simulate control and response

  14. ADVANCING THE SCIENCE OF NATURAL AND ENHANCED ATTENUATION FOR CHLORINATED SOLVENTS

    Energy Technology Data Exchange (ETDEWEB)

    Looney, B; TOM O. EARLY, T; TYLER GILMORE, T; FRANCIS H. CHAPELLE, F; NORMAN H. CUTSHALL, N; JEFF ROSS, J; MARK ANKENY, M; Michael Heitkamp, M; DAVID MAJOR, D; CHARLES J. NEWELL, C; W. JODY WAUGH, W; GARY WEIN, G; Karen Vangelas, K; Karen-M Adams, K; CLAIRE H. SINK, C

    2006-12-27

    This report summarizes the results of a three-year program that addressed key scientific and technical aspects related to natural and enhanced attenuation of chlorinated organics. The results from this coordinated three-year program support a variety of technical and regulatory advancements. Scientists, regulators, engineers, end-users and stakeholders participated in the program, which was supported by the U.S. Department of Energy (DOE) and the Interstate Technology and Regulatory Council (ITRC). The overarching objective of the effort was to examine environmental remedies that are based on natural processes--remedies such as Monitored Natural Attenuation (MNA) or Enhanced Attenuation (EA). A key result of the recent effort was the general affirmation of the approaches and guidance in the original U.S. Environmental Protection Agency (EPA) chlorinated solvent MNA protocols and directives from 1998 and 1999, respectively. The research program did identify several specific opportunities for advances based on: (1) mass balance as the central framework for attenuation based remedies, (2) scientific advancements and achievements during the past ten years, (3) regulatory and policy development and real-world experience using MNA, and (4) exploration of various ideas for integrating attenuation remedies into a systematic set of ''combined remedies'' for contaminated sites. These opportunities are summarized herein and are addressed in more detail in referenced project documents and journal articles, as well as in the technical and regulatory documents being developed within the ITRC. Natural attenuation processes occur in all soil and groundwater systems and act, to varying degrees, on all contaminants. Thus, a decision to rely on natural attenuation processes as part of a site-remediation strategy does not depend on the occurrence of natural attenuation, but on its effectiveness in meeting site-specific remediation goals. Meeting these goals

  15. Requirements for a Dynamic Solvent Extraction Module to Support Development of Advanced Technologies for the Recycle of Used Nuclear Fuel

    Energy Technology Data Exchange (ETDEWEB)

    Jack Law; Veronica Rutledge; Candido Pereira; Jackie Copple; Kurt Frey; John Krebs; Laura Maggos; Kevin Nichols; Kent Wardle; Pratap Sadasivan; Valmor DeAlmieda; David Depaoli

    2011-06-01

    The Department of Energy's Nuclear Energy Advanced Modeling and Simulation (NEAMS) Program has been established to create and deploy next generation, verified and validated nuclear energy modeling and simulation capabilities for the design, implementation, and operation of future nuclear energy systems to improve the U.S. energy security. As part of the NEAMS program, Integrated Performance and Safety Codes (IPSC's) are being produced to significantly advance the status of modeling and simulation of energy systems beyond what is currently available to the extent that the new codes be readily functional in the short term and extensible in the longer term. The four IPSC areas include Safeguards and Separations, Reactors, Fuels, and Waste Forms. As part of the Safeguards and Separations (SafeSeps) IPSC effort, interoperable process models are being developed that enable dynamic simulation of an advanced separations plant. A SafeSepss IPSC 'toolkit' is in development to enable the integration of separation process modules and safeguards tools into the design process by providing an environment to compose, verify and validate a simulation application to be used for analysis of various plant configurations and operating conditions. The modules of this toolkit will be implemented on a modern, expandable architecture with the flexibility to explore and evaluate a wide range of process options while preserving their stand-alone usability. Modules implemented at the plant-level will initially incorporate relatively simple representations for each process through a reduced modeling approach. Final versions will incorporate the capability to bridge to subscale models to provide required fidelity in chemical and physical processes. A dynamic solvent extraction model and its module implementation are needed to support the development of this integrated plant model. As a stand-alone application, it will also support solvent development of extraction flowsheets

  16. Recent advances on integrated quantum communications

    Science.gov (United States)

    Orieux, Adeline; Diamanti, Eleni

    2016-08-01

    In recent years, the use of integrated technologies for applications in the field of quantum information processing and communications has made great progress. The resulting devices feature valuable characteristics such as scalability, reproducibility, low cost and interconnectivity, and have the potential to revolutionize our computation and communication practices in the future, much in the way that electronic integrated circuits have drastically transformed our information processing capacities since the last century. Among the multiple applications of integrated quantum technologies, this review will focus on typical components of quantum communication systems and on overall integrated system operation characteristics. We are interested in particular in the use of photonic integration platforms for developing devices necessary in quantum communications, including sources, detectors and both passive and active optical elements. We also illustrate the challenges associated with performing quantum communications on chip, by using the case study of quantum key distribution—the most advanced application of quantum information science. We conclude with promising perspectives in this field.

  17. Integrating Advanced Molecular Technologies into Public Health.

    Science.gov (United States)

    Gwinn, Marta; MacCannell, Duncan R; Khabbaz, Rima F

    2017-03-01

    Advances in laboratory and information technologies are transforming public health microbiology. High-throughput genome sequencing and bioinformatics are enhancing our ability to investigate and control outbreaks, detect emerging infectious diseases, develop vaccines, and combat antimicrobial resistance, all with increased accuracy, timeliness, and efficiency. The Advanced Molecular Detection (AMD) initiative has allowed the Centers for Disease Control and Prevention (CDC) to provide leadership and coordination in integrating new technologies into routine practice throughout the U.S. public health laboratory system. Collaboration and partnerships are the key to navigating this transition and to leveraging the next generation of methods and tools most effectively for public health.

  18. Advanced materials for integrated optical waveguides

    CERN Document Server

    Tong Ph D, Xingcun Colin

    2014-01-01

    This book provides a comprehensive introduction to integrated optical waveguides for information technology and data communications. Integrated coverage ranges from advanced materials, fabrication, and characterization techniques to guidelines for design and simulation. A concluding chapter offers perspectives on likely future trends and challenges. The dramatic scaling down of feature sizes has driven exponential improvements in semiconductor productivity and performance in the past several decades. However, with the potential of gigascale integration, size reduction is approaching a physical limitation due to the negative impact on resistance and inductance of metal interconnects with current copper-trace based technology. Integrated optics provides a potentially lower-cost, higher performance alternative to electronics in optical communication systems. Optical interconnects, in which light can be generated, guided, modulated, amplified, and detected, can provide greater bandwidth, lower power consumption, ...

  19. Quantum-classical path integral with self-consistent solvent-driven reference propagators.

    Science.gov (United States)

    Banerjee, Tuseeta; Makri, Nancy

    2013-10-24

    Efficient procedures for evaluating the quantum-classical path integral (QCPI) [J. Chem. Phys. 2013, 137, 22A552] are described. The main idea is to identify a trajectory-specific reference Hamiltonian that captures the dominant effects of the classical "solvent" degrees of freedom on the dynamics of the quantum "system". This time-dependent reference is used to construct a system propagator that is valid for large time increments. Residual "quantum memory" interactions are included via the path integral representation of the density matrix, which converges with large time steps. Two physically motivated reference schemes are considered. The first involves the dynamics of the solvent unperturbed by the system, which forms the basis for the "classical path" approximation. The second is based on solvent trajectories determined self-consistently with the evolution of the system, according to the time-dependent self-consistent field or Ehrenfest model. Application to dissipative two-level systems indicates that both reference schemes allow a substantial increase of the path integral time step, leading to rapid convergence of the path sum. In addition, the time-dependent reference propagators automatically weigh state-to-state coupling against solvent reorganization in the determination of transition probabilities, further enhancing the convergence of the path integral.

  20. INTEGRATED PLASMA CONTROL FOR ADVANCED TOKAMAKS

    Energy Technology Data Exchange (ETDEWEB)

    HUMPHREYS,D.A; FERRON,J.R; JOHNSON,R.D; LEUER,J.A; PENAFLOR,B.G; WALKER,M.L; WELANDER,A.S; KHAYRUTDINOV,R.R; DOKOUKA,V; EDGELL,D.H; FRANSSON,C.M

    2003-10-01

    OAK-B135 Advanced tokamaks (AT) are distinguished from conventional tokamaks by their high degree of shaping, achievement of profiles optimized for high confinement and stability characteristics, and active stabilization of MHD instabilities to attain high values of normalized beta and confinement. These high performance fusion devices thus require accurate regulation of the plasma boundary, internal profiles, pumping, fueling, and heating, as well as simultaneous and well-coordinated MHD control action to stabilize such instabilities as tearing modes and resistive wall modes. Satisfying the simultaneous demands on control accuracy, reliability, and performance for all of these subsystems requires a high degree of integration in both design and operation of the plasma control system in an advanced tokamak. The present work describes the approach, benefits, and progress made in integrated plasma control with application examples drawn from the DIII-D tokamak. The approach includes construction of plasma and system response models, validation of models against operating experiments, design of integrated controllers which operate in concert with one another as well as with supervisory modules, simulation of control action against off-line and actual machine control platforms, and iteration of the design-test loop to optimize performance.

  1. Final Report - Energy Reduction and Advanced Water Removal via Membrane Solvent Extraction Technology

    Energy Technology Data Exchange (ETDEWEB)

    Reed, John; Fanselow, Dan; Abbas, Charles; Sammons, Rhea; Kinchin, Christopher

    2014-08-06

    3M and Archer Daniels Midland (ADM) collaborated with the U.S. Department of Energy (DOE) to develop and demonstrate a novel membrane solvent extraction (MSE) process that can substantially reduce energy and water consumption in ethanol production, and accelerate the fermentation process. A cross-flow membrane module was developed, using porous membrane manufactured by 3M. A pilot process was developed that integrates fermentation, MSE and vacuum distillation. Extended experiments of 48-72 hours each were conducted to develop the process, verify its performance and begin establishing commercial viability.

  2. Nuclear integrated database and design advancement system

    Energy Technology Data Exchange (ETDEWEB)

    Ha, Jae Joo; Jeong, Kwang Sub; Kim, Seung Hwan; Choi, Sun Young

    1997-01-01

    The objective of NuIDEAS is to computerize design processes through an integrated database by eliminating the current work style of delivering hardcopy documents and drawings. The major research contents of NuIDEAS are the advancement of design processes by computerization, the establishment of design database and 3 dimensional visualization of design data. KSNP (Korea Standard Nuclear Power Plant) is the target of legacy database and 3 dimensional model, so that can be utilized in the next plant design. In the first year, the blueprint of NuIDEAS is proposed, and its prototype is developed by applying the rapidly revolutionizing computer technology. The major results of the first year research were to establish the architecture of the integrated database ensuring data consistency, and to build design database of reactor coolant system and heavy components. Also various softwares were developed to search, share and utilize the data through networks, and the detailed 3 dimensional CAD models of nuclear fuel and heavy components were constructed, and walk-through simulation using the models are developed. This report contains the major additions and modifications to the object oriented database and associated program, using methods and Javascript.. (author). 36 refs., 1 tab., 32 figs.

  3. Technology advancement for integrative stem cell analyses.

    Science.gov (United States)

    Jeong, Yoon; Choi, Jonghoon; Lee, Kwan Hyi

    2014-12-01

    Scientists have endeavored to use stem cells for a variety of applications ranging from basic science research to translational medicine. Population-based characterization of such stem cells, while providing an important foundation to further development, often disregard the heterogeneity inherent among individual constituents within a given population. The population-based analysis and characterization of stem cells and the problems associated with such a blanket approach only underscore the need for the development of new analytical technology. In this article, we review current stem cell analytical technologies, along with the advantages and disadvantages of each, followed by applications of these technologies in the field of stem cells. Furthermore, while recent advances in micro/nano technology have led to a growth in the stem cell analytical field, underlying architectural concepts allow only for a vertical analytical approach, in which different desirable parameters are obtained from multiple individual experiments and there are many technical challenges that limit vertically integrated analytical tools. Therefore, we propose--by introducing a concept of vertical and horizontal approach--that there is the need of adequate methods to the integration of information, such that multiple descriptive parameters from a stem cell can be obtained from a single experiment.

  4. Integrating advanced facades into high performance buildings

    Energy Technology Data Exchange (ETDEWEB)

    Selkowitz, Stephen E.

    2001-05-01

    Glass is a remarkable material but its functionality is significantly enhanced when it is processed or altered to provide added intrinsic capabilities. The overall performance of glass elements in a building can be further enhanced when they are designed to be part of a complete facade system. Finally the facade system delivers the greatest performance to the building owner and occupants when it becomes an essential element of a fully integrated building design. This presentation examines the growing interest in incorporating advanced glazing elements into more comprehensive facade and building systems in a manner that increases comfort, productivity and amenity for occupants, reduces operating costs for building owners, and contributes to improving the health of the planet by reducing overall energy use and negative environmental impacts. We explore the role of glazing systems in dynamic and responsive facades that provide the following functionality: Enhanced sun protection and cooling load control while improving thermal comfort and providing most of the light needed with daylighting; Enhanced air quality and reduced cooling loads using natural ventilation schemes employing the facade as an active air control element; Reduced operating costs by minimizing lighting, cooling and heating energy use by optimizing the daylighting-thermal tradeoffs; Net positive contributions to the energy balance of the building using integrated photovoltaic systems; Improved indoor environments leading to enhanced occupant health, comfort and performance. In addressing these issues facade system solutions must, of course, respect the constraints of latitude, location, solar orientation, acoustics, earthquake and fire safety, etc. Since climate and occupant needs are dynamic variables, in a high performance building the facade solution have the capacity to respond and adapt to these variable exterior conditions and to changing occupant needs. This responsive performance capability

  5. Advanced Low Energy Enzyme Catalyzed Solvent for CO{sub 2} Capture

    Energy Technology Data Exchange (ETDEWEB)

    Zaks, Alex; Reardon, John

    2013-09-30

    A proof-of-concept biocatalyst enhanced solvent process was developed and demonstrated in an integrated bench-scale system using coal post combustion flue gas. The biocatalyst was deployed as a coating on M500X structured packing. Rate enhancement was evaluated using a non-volatile and non- toxic 20 wt% potassium carbonate solution. Greater than 500-fold volumetric scale-up from laboratory to bench scale was demonstrated in this project. Key technical achievements included: 10-fold mass transfer enhancement demonstrated in laboratory testing relative to blank potassium carbonate at 45°C; ~ 7-fold enhancement over blank in bench-scale field testing at National Carbon Capture Center; aerosol emissions were below detection limits (< 0.8 ppm); 90% capture was demonstrated at ~19.5 Nm{sup 3}/hr (dry basis); and ~ 80% CO{sub 2} capture was demonstrated at ~ 30 Nm{sup 3}/hr (dry basis) for more than 2800-hrs on flue gas with minimal detectible decline in activity. The regeneration energy requirement was 3.5 GJ/t CO{sub 2} for this solvent, which was below the target of <2.1 GJ/t CO{sub 2}. Bench unit testing revealed kinetic limitations in the un-catalyzed stripper at around 85°C, but process modeling based on bench unit data showed that equivalent work of less than 300 kWh/t CO{sub 2} including all CO{sub 2} compression can be achieved at lower temperature stripping conditions. Cost analysis showed that 20% potassium carbonate in a basic solvent flow sheet with biocatalyst coated packing has economic performance comparable to the reference NETL Case-12, 30% MEA. A detailed techno-economic analysis indicated that addition of catalyst in the stripper could reduce the cost of capture by ~6% and cost of avoided CO{sub 2} by ~10% below reference NETL Case-12. Based on these results, a directional plan was identified to reduce the cost of CO{sub 2} capture in future work.

  6. The advanced microgrid. Integration and interoperability

    Energy Technology Data Exchange (ETDEWEB)

    Bower, Ward Isaac [Ward Bower Innovations, LLC, Albuquerque, NM (United Staes); Ton, Dan T. [U.S. Dept. of Energy, Washington, DC (United States); Guttromson, Ross [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Glover, Steven F [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Stamp, Jason Edwin [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Bhatnagar, Dhruv [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Reilly, Jim [Reily Associates, Pittston, PA (United States)

    2014-02-01

    This white paper focuses on "advanced microgrids," but sections do, out of necessity, reference today's commercially available systems and installations in order to clearly distinguish the differences and advances. Advanced microgrids have been identified as being a necessary part of the modern electrical grid through a two DOE microgrid workshops, the National Institute of Standards and Technology, Smart Grid Interoperability Panel and other related sources. With their grid-interconnectivity advantages, advanced microgrids will improve system energy efficiency and reliability and provide enabling technologies for grid-independence to end-user sites. One popular definition that has been evolved and is used in multiple references is that a microgrid is a group of interconnected loads and distributed-energy resources within clearly defined electrical boundaries that acts as a single controllable entity with respect to the grid. A microgrid can connect and disconnect from the grid to enable it to operate in both grid-connected or island-mode. Further, an advanced microgrid can then be loosely defined as a dynamic microgrid.

  7. Integrating advanced reasoning into a SAT solver

    Institute of Scientific and Technical Information of China (English)

    DING Min; TANG Pushan; ZHOU Dian

    2005-01-01

    In this paper, we present a SAT solver based on the combination of DPLL (Davis Putnam Logemann and Loveland) algorithm and Failed Literal Detection (FLD), one of the advanced reasoning techniques. We propose a Dynamic Filtering method that consists of two restriction rules for FLD: internal and external filtering. The method reduces the number of tested literals in FLD and its computational time while maintaining the ability to find most of the failed literals in each decision level. Unlike the pre-defined criteria, literals are removed dynamically in our approach. In this way, our FLD can adapt itself to different real-life benchmarks. Many useless tests are therefore avoided and as a consequence it makes FLD fast. Some other static restrictions are also added to further improve the efficiency of FLD. Experiments show that our optimized FLD is much more efficient than other advanced reasoning techniques.

  8. Advances in the theory of box integrals

    Energy Technology Data Exchange (ETDEWEB)

    Bailey, David H.; Borwein, J.M.; Crandall, R.E.

    2009-06-25

    Box integrals - expectations <|{rvec r}|{sup s}> or <|{rvec r}-{rvec q}|{sup s}> over the unit n-cube (or n-box) - have over three decades been occasionally given closed forms for isolated n,s. By employing experimental mathematics together with a new, global analytic strategy, we prove that for n {le} 4 dimensions the box integrals are for any integer s hypergeometrically closed in a sense we clarify herein. For n = 5 dimensions, we show that a single unresolved integral we call K{sub 5} stands in the way of such hyperclosure proofs. We supply a compendium of exemplary closed forms that naturally arise algorithmically from this theory.

  9. Advancing Instructional Communication: Integrating a Biosocial Approach

    Science.gov (United States)

    Horan, Sean M.; Afifi, Tamara D.

    2014-01-01

    Celebrating 100 years of the National Communication Association necessitates that, as we commemorate our past, we also look toward our future. As part of a larger conversation about the future of instructional communication, this essay reinvestigates the importance of integrating biosocial approaches into instructional communication research. In…

  10. Recent advances in quantum integrable systems

    Energy Technology Data Exchange (ETDEWEB)

    Amico, L.; Belavin, A.; Buffenoir, E.; Castro Alvaredo, A.; Caudrelier, V.; Chakrabarti, A.; Corrig, E.; Crampe, N.; Deguchi, T.; Dobrev, V.K.; Doikou, A.; Doyon, B.; Feher, L.; Fioravanti, D.; Gohmann, F.; Hallnas, M.; Jimbo, M.; Konno, N.C.H.; Korchemsky, G.; Kulish, P.; Lassalle, M.; Maillet, J.M.; McCoy, B.; Mintchev, M.; Pakuliak, S.; Quano, F.Y.Z.; Ragnisco, R.; Ravanini, F.; Rittenberg, V.; Rivasseau, V.; Rossi, M.; Satta, G.; Sedrakyan, T.; Shiraishi, J.; Suzuki, N.C.J.; Yamada, Y.; Zamolodchikov, A.; Ishimoto, Y.; Nagy, Z.; Posta, S.; Sedra, M.B.; Zuevskiy, A.; Gohmann, F

    2005-07-01

    This meeting was dedicated to different aspects of the theory of quantum integrable systems. The organizers have intended to concentrate on topics related to the study of correlation functions, to systems with boundaries and to models at roots of unity. This document gathers the abstracts of 32 contributions, most of the contributions are accompanied by the set of transparencies.

  11. Advanced techniques for efficient data integrity checking

    DEFF Research Database (Denmark)

    Martinenghi, Davide

    ” that may go beyond predefined constraints such as primary keys and foreign keys. General integrity constraints are, however, far from being widely available in commercial systems; in fact, their usage is commonly not encouraged, since the database management system would not be able to provide...... their incremental evaluation. Given the size of today’s data repositories and the frequency at which updates may occur, any non-incremental approach, even for conditions whose complexity is only linear in the size of the database, may prove unfeasible in practice. Typically it is the database designer...... modifications in such programs. In this respect, database management systems need to be extended with means to verify, automatically and incrementally, that no violation of integrity is introduced by database updates. For this purpose we develop a procedure aimed at producing incremental checks whose...

  12. Advanced Wireless Integrated Navy Network (AWINN)

    Science.gov (United States)

    2005-12-31

    was developed, with components to model sensor and air defense cannon control systems, a tracking service, and a command-and-control (C2) capability...and respond to failed control services. From time to time, a cannon control service will fail, modeling an enemy strike, hardware/software fault, or...The expression in (4.1-24) can be easily evaluated using numerical integration using Gauss -Chebyshev quadrature method for all the known fading

  13. Demonstration of advanced APBS solvent at TNO's CO2 capture pilot plant

    NARCIS (Netherlands)

    Bumb, P.; Kumar, R.; Khakharia, P.M.; Goetheer, E.L.V.

    2014-01-01

    The company Carbon Clean Solutions (CCS) has developed a variety of energy efficient solvents and processes such as PCCMax, which aim to reduce the overall operating and capital cost of CO2 capture. Highly successful R&D in collaboration with TNO, considering aspects from fundamental properties such

  14. Low Cost, Advanced, Integrated Microcontroller Training Kit

    Science.gov (United States)

    Somantri, Y.; Fushshilat, I.

    2017-03-01

    This paper describes the design of an AVR microcontroller training kit with a low cost and the additional feature of an integrated downloader. The main components of this device include: Microcontroller, terminal, I/O keypad, push button, LED, seven segment display, LCD, motor stepper, and sensors. The device configuration results in low cost and ease of use; this device is suitable for laboratories with limited funding. The device can also be used as a training kit for the teaching and learning of microcontrollers.

  15. Advanced integrated WDM system for POF communication

    Science.gov (United States)

    Haupt, M.; Fischer, U. H. P.

    2009-01-01

    Polymer Optical Fibres (POFs) show clear advantages compared to copper and glass fibres. In essence, POFs are inexpensive, space-saving and not susceptible to electromagnetic interference. Thus, the usage of POFs have become a reasonable alternative in short distance data communication. Today, POFs are applied in a wide number of applications due to these specific advantages. These applications include automotive communication systems and in-house-networks. State-of-the-art is to transmit data with only one channel over POF, this limits the bandwidth. To solve this problem, an integrated MUX/DEMUX-element for WDM over POF is designed and developed to use multiple channels. This integration leads to low costs, therefore this component is suitable for mass market applications. The fundamental idea is to separate the chromatic parts of the light in its monochromatic components by means of a grating based on an aspheric mirror. Due to the high NA of the POF the setup has to be designed in a 3D-approach. Therefore this setup cannot be compared with the planar solutions available on market, they would result high losses in the 3rd dimension. To achieve a fast and optimized design an optical simulation program is used. Particular attention has to be paid to the design of the POF as a light source in the simulation program and the optimisation of the grating. The following realization of the demultiplexer is planed to be done with injection molding. This technology offers easy and very economical processing. These advantages make this technology first choice for optical components in the low-cost array.

  16. Advances in Solvent Effect of Quaternarization%季铵化反应中的溶剂效应

    Institute of Scientific and Technical Information of China (English)

    蒋波; 詹晓力; 陈丰秋

    2006-01-01

      Quaternarization is an important SN2 nucleophilic substitution reaction;solvent has remarkable effect on it. The recent advances in solvent effect of quaternarization were summarized. We emphasized on the empirical correlation of quaternarization reaction rate, quaternarization transition state theory proposed by Abraham, quantum chemistry and molecular simulation which were implied to study the solvent effect quantitatively. The results acquired by different methods and problems were discussed.%  季铵化反应是一类重要的SN2亲核取代反应,溶剂对该反应的影响很显著。本文综述了近年来季铵化反应中溶剂效应的研究进展,介绍了季铵化反应速率的经验关联式、Abraham提出的季铵化反应过渡态理论,以及量子化学和分子模拟在季铵化反应的溶剂效应研究中的应用,并讨论了不同研究方法取得的结果和存在的问题。

  17. Integration of advanced nuclear materials separation processes

    Energy Technology Data Exchange (ETDEWEB)

    Jarvinen, G.D.; Worl, L.A.; Padilla, D.D.; Berg, J.M.; Neu, M.P.; Reilly, S.D.; Buelow, S.

    1998-12-31

    This is the final report of a two-year, Laboratory Directed Research and Development (LDRD) project at the Los Alamos National Laboratory (LANL). This project has examined the fundamental chemistry of plutonium that affects the integration of hydrothermal technology into nuclear materials processing operations. Chemical reactions in high temperature water allow new avenues for waste treatment and radionuclide separation.Successful implementation of hydrothermal technology offers the potential to effective treat many types of radioactive waste, reduce the storage hazards and disposal costs, and minimize the generation of secondary waste streams. The focus has been on the chemistry of plutonium(VI) in solution with carbonate since these are expected to be important species in the effluent from hydrothermal oxidation of Pu-containing organic wastes. The authors investigated the structure, solubility, and stability of the key plutonium complexes. Installation and testing of flow and batch hydrothermal reactors in the Plutonium Facility was accomplished. Preliminary testing with Pu-contaminated organic solutions gave effluent solutions that readily met discard requirements. A new effort in FY 1998 will build on these promising initial results.

  18. ADVANCED COMPRESSOR ENGINE CONTROLS TO ENHANCE OPERATION, RELIABILITY AND INTEGRITY

    Energy Technology Data Exchange (ETDEWEB)

    Gary D. Bourn; Jess W. Gingrich; Jack A. Smith

    2004-03-01

    This document is the final report for the ''Advanced Compressor Engine Controls to Enhance Operation, Reliability, and Integrity'' project. SwRI conducted this project for DOE in conjunction with Cooper Compression, under DOE contract number DE-FC26-03NT41859. This report addresses an investigation of engine controls for integral compressor engines and the development of control strategies that implement closed-loop NOX emissions feedback.

  19. Advanced Communication System in Substation for Integrated Protection

    Institute of Scientific and Technical Information of China (English)

    HE Jinghan; REN Yingli; BO Zhiqian; Klimek Adrew

    2008-01-01

    This paper proposes an advanced substation integrated protection communication sys- tem based on the latest development in power system. The integrated protection communication system within a substation comprises a number of major components such as the merging unit, communication network and integrated protection unit. The design and capability evaluation of the communication network based on IEC61850 are focused on. Results show that huge information from 4 merging units can be transmitted real-time via adopting 100 Mbit/s optical fiber in a sub-station, and the proposed communication network is able to achieve required performance.

  20. Material Protection, Accounting, and Control Technologies (MPACT) Advanced Integration Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    Miller, Mike [Idaho National Lab. (INL), Idaho Falls, ID (United States); Cipiti, Ben [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Demuth, Scott Francis [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Durkee, Jr., Joe W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Fallgren, Andrew James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Jarman, Ken [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Li, Shelly [Idaho National Lab. (INL), Idaho Falls, ID (United States); Meier, Dave [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Osburn, Laura Ann [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Pereira, Candido [Argonne National Lab. (ANL), Argonne, IL (United States); Dasari, Venkateswara Rao [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Ticknor, Lawrence O. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Yoo, Tae-Sic [Idaho National Lab. (INL), Idaho Falls, ID (United States)

    2017-01-30

    The development of sustainable advanced nuclear fuel cycles is a long-term goal of the Office of Nuclear Energy’s (DOE-NE) Fuel Cycle Technologies program. The Material Protection, Accounting, and Control Technologies (MPACT) campaign is supporting research and development (R&D) of advanced instrumentation, analysis tools, and integration methodologies to meet this goal (Miller, 2015). This advanced R&D is intended to facilitate safeguards and security by design of fuel cycle facilities. The lab-scale demonstration of a virtual facility, distributed test bed, that connects the individual tools being developed at National Laboratories and university research establishments, is a key program milestone for 2020. These tools will consist of instrumentation and devices as well as computer software for modeling, simulation and integration.

  1. Material Protection, Accounting, and Control Technologies (MPACT) Advanced Integration Roadmap

    Energy Technology Data Exchange (ETDEWEB)

    Durkee, Joe W. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Cipiti, Ben [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Demuth, Scott Francis [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Fallgren, Andrew James [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Jarman, Ken [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Li, Shelly [Argonne National Lab. (ANL), Argonne, IL (United States); Meier, Dave [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Miller, Mike [Argonne National Lab. (ANL), Argonne, IL (United States); Osburn, Laura Ann [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Pereira, Candido [Argonne National Lab. (ANL), Argonne, IL (United States); Dasari, Venkateswara Rao [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Ticknor, Lawrence O. [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Yoo, Tae-Sic [Argonne National Lab. (ANL), Argonne, IL (United States)

    2016-09-30

    The development of sustainable advanced nuclear fuel cycles is a long-term goal of the Office of Nuclear Energy’s (DOE-NE) Fuel Cycle Technologies program. The Material Protection, Accounting, and Control Technologies (MPACT) campaign is supporting research and development (R&D) of advanced instrumentation, analysis tools, and integration methodologies to meet this goal (Miller, 2015). This advanced R&D is intended to facilitate safeguards and security by design of fuel cycle facilities. The lab-scale demonstration of a virtual facility, distributed test bed, that connects the individual tools being developed at National Laboratories and university research establishments, is a key program milestone for 2020. These tools will consist of instrumentation and devices as well as computer software for modeling, simulation and integration.

  2. Probing Ternary Solvent Effect in High V(oc) Polymer Solar Cells Using Advanced AFM Techniques.

    Science.gov (United States)

    Li, Chao; Ding, Yi; Soliman, Mikhael; Lorenzo, Josie; Dhasmana, Nitesh; Chantharasupawong, Panit; Ievlev, Anton V; Gesquiere, Andre J; Tetard, Laurene; Thomas, Jayan

    2016-02-01

    This work describes a simple method to develop a high V(oc) low band gap PSCs. In addition, two new atomic force microscopy (AFM)-based nanoscale characterization techniques to study the surface morphology and physical properties of the structured active layer are introduced. With the help of ternary solvent processing of the active layer and C60 buffer layer, a bulk heterojunction PSC with V(oc) more than 0.9 V and conversion efficiency 7.5% is developed. In order to understand the fundamental properties of the materials ruling the performance of the PSCs tested, AFM-based nanoscale characterization techniques including Pulsed-Force-Mode AFM (PFM-AFM) and Mode-Synthesizing AFM (MSAFM) are introduced. Interestingly, MSAFM exhibits high sensitivity for direct visualization of the donor-acceptor phases in the active layer of the PSCs. Finally, conductive-AFM (cAFM) studies reveal local variations in conductivity in the donor and acceptor phases as well as a significant increase in photocurrent in the PTB7:ICBA sample obtained with the ternary solvent processing.

  3. Amine Solvent Regeneration for CO2 Capture Using Geothermal Energy with Advanced Stripper Configurations

    Directory of Open Access Journals (Sweden)

    Van Wagener D.H.

    2014-11-01

    Full Text Available Absorption/stripping using alkanolamine solvents for removing CO2 from the flue gas of coal-fired power plants requires a substantial amount of energy. Typical designs anticipate the use of steam extraction between the Intermediate Pressure (IP and Low Pressure (LP turbines to provide heat for the reboiler. Geothermal energy in the form of hot brine offers an alternative to this large parasitic load on the power generation cycle. We investigate the requirements (number and spacing of extraction/injection well pairs to provide heat at 150°C for a pilot scale (60 MWe and a full scale (900 MWe capture process for thirty years. The calculations are based on properties of a geopressured/geothermal aquifer near the Texas Gulf Coast. In the vicinity of a large coal-fired power plant in South Texas, this aquifer lies between 3 050 and 3 350 m (10 000 and 11 000 ft below the surface. We present a novel design of the stripper/regenerator process based on heat exchange with the brine, discharging the brine at 100°C. The results indicate that the overall process is feasible and that costs are of similar magnitude to standard designs.

  4. Advanced Integrated Power and Attitude Control System (IPACS) study

    Science.gov (United States)

    Oglevie, R. E.; Eisenhaure, D. B.

    1985-01-01

    Integrated Power and Attitude Control System (IPACS) studies performed over a decade ago established the feasibility of simultaneously satisfying the demands of energy storage and attitude control through the use of rotating flywheels. It was demonstrated that, for a wide spectrum of applications, such a system possessed many advantages over contemporary energy storage and attitude control approaches. More recent technology advances in composite material rotors, magnetic suspension systems, and power control electronics have triggered new optimism regarding the applicability and merits of this concept. This study is undertaken to define an advanced IPACS and to evaluate its merits for a space station application. System and component designs are developed to establish the performance of this concept and system trade studies conducted to examine the viability of this approach relative to conventional candidate systems. It is clearly demonstrated that an advanced IPACS concept is not only feasible, but also offers substantial savings in mass and life-cycle cost for the space station mission.

  5. Advanced Laser Chemical Processing For Microelectronics and Integrated Optics

    Science.gov (United States)

    1992-08-15

    Barbara, CA (June 25-27, 1990). 15. R.M. Osgood, Jr., " Laser - Fabrication for Integrated Electronics and Optics," OITDA Conference, Tokyo, Japan, (July 5...Society Meeting, Boston, MA, November 26 - December 3, 1990. 20. R.M. Osgood, Jr., "Advances in Laser Fabrication for Solid-State Electronics and...Thin, Excimer Laser-Deposited Cd Interlayers," J. Elec. Mat. 12, 1239 (July, 1990). 14. R.M. Osgood, Jr., " Laser - Fabrication for Solid State

  6. Advances in organic field-effect transistors and integrated circuits

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    Organic field-effect transistors (OFETs) have received significant research interest because of their promising applications in low cast, lager area, plastic circuits, and tremendous progress has been made in materials, device performance, OFETs based circuits in recent years. In this article we introduce the advances in organic semiconductor materials, OFETs based integrating techniques, and in particular highlight the recent progress. Finally, the prospects and problems of OFETs are discussed.

  7. Advances in Developing Transitions in Microwave Integrated Circuits

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yun-chuan; WANG Bing-zhong

    2005-01-01

    Advances in developing transitions in microwave integrated circuits during the last ten years are reviewed. Some typical structures of transition are introduced. Transition structures can be classified into two basic types: one is transition between the same kind of transmission lines on different planes of a common substrate, the other transition between different types of transmission lines.Furthermore, future development of transition structures is discussed.

  8. Advances in organic field-effect transistors and integrated circuits

    Institute of Scientific and Technical Information of China (English)

    WANG Hong; JI ZhuoYu; LIU Ming; SHANG LiWei; LIU Ge; LIU XingHua; LIU Jiang; PENG YingQuan

    2009-01-01

    Organic field-effect transistors (OFETs) have received significant research interest because of their promising applications in low cast, lager area, plastic circuits, and tremendous progress has been made in materials, device performance, OFETs based circuits in recent years.In this article we intro-duce the advances in organic semiconductor materials, OFETs based integrating techniques, and in particular highlight the recent progress.Finally, the prospects and problems of OFETs are discussed.

  9. Foundational development of an advanced nuclear reactor integrated safety code.

    Energy Technology Data Exchange (ETDEWEB)

    Clarno, Kevin (Oak Ridge National Laboratory, Oak Ridge, TN); Lorber, Alfred Abraham; Pryor, Richard J.; Spotz, William F.; Schmidt, Rodney Cannon; Belcourt, Kenneth (Ktech Corporation, Albuquerque, NM); Hooper, Russell Warren; Humphries, Larry LaRon

    2010-02-01

    This report describes the activities and results of a Sandia LDRD project whose objective was to develop and demonstrate foundational aspects of a next-generation nuclear reactor safety code that leverages advanced computational technology. The project scope was directed towards the systems-level modeling and simulation of an advanced, sodium cooled fast reactor, but the approach developed has a more general applicability. The major accomplishments of the LDRD are centered around the following two activities. (1) The development and testing of LIME, a Lightweight Integrating Multi-physics Environment for coupling codes that is designed to enable both 'legacy' and 'new' physics codes to be combined and strongly coupled using advanced nonlinear solution methods. (2) The development and initial demonstration of BRISC, a prototype next-generation nuclear reactor integrated safety code. BRISC leverages LIME to tightly couple the physics models in several different codes (written in a variety of languages) into one integrated package for simulating accident scenarios in a liquid sodium cooled 'burner' nuclear reactor. Other activities and accomplishments of the LDRD include (a) further development, application and demonstration of the 'non-linear elimination' strategy to enable physics codes that do not provide residuals to be incorporated into LIME, (b) significant extensions of the RIO CFD code capabilities, (c) complex 3D solid modeling and meshing of major fast reactor components and regions, and (d) an approach for multi-physics coupling across non-conformal mesh interfaces.

  10. Enhanced performance in graphene RF transistors via advanced process integration

    Science.gov (United States)

    Hong, Seul Ki; Oh, Joong Gun; Hwang, Wan Sik; Cho, Byung Jin

    2017-04-01

    The state-of-the-art performance of a graphene radio-frequency (RF) field-effect transistor (FET) made of chemical vapor deposition (CVD) graphene is presented. The record high cut-off frequency as high as 380 GHz using CVD graphene was attributed to the implementation of advanced process integration. On the one hand, interface engineering has become critical in two-dimensional (2D) electronics since the charge transport of a 2D electron system like graphene is highly affected by the interface. The interface engineering was made for both the top and bottom of the graphene surface by implementing a non-polar material (1, 3, 5-trimethyl-1, 3, 5-trivinyl cyclotrisiloxane). In contrast to conventional polar materials, such as SiO2, the non-polar materials significantly reduce the surface optical phonon scattering in the graphene channel, leading to the enhanced RF performance of graphene FET. On the other hand, micro-scaled holes over the multilayer graphene and self-aligned structure also become a critical factor in minimizing the parasitic resistance that is inversely proportional to RF performance. As the growth technique of CVD graphene greatly advances, the advanced process integration scheme could bring graphene electronics one step further towards practical application.

  11. Integration of Advanced Simulation and Visualization for Manufacturing Process Optimization

    Science.gov (United States)

    Zhou, Chenn; Wang, Jichao; Tang, Guangwu; Moreland, John; Fu, Dong; Wu, Bin

    2016-05-01

    The integration of simulation and visualization can provide a cost-effective tool for process optimization, design, scale-up and troubleshooting. The Center for Innovation through Visualization and Simulation (CIVS) at Purdue University Northwest has developed methodologies for such integration with applications in various manufacturing processes. The methodologies have proven to be useful for virtual design and virtual training to provide solutions addressing issues on energy, environment, productivity, safety, and quality in steel and other industries. In collaboration with its industrial partnerships, CIVS has provided solutions to companies, saving over US38 million. CIVS is currently working with the steel industry to establish an industry-led Steel Manufacturing Simulation and Visualization Consortium through the support of National Institute of Standards and Technology AMTech Planning Grant. The consortium focuses on supporting development and implementation of simulation and visualization technologies to advance steel manufacturing across the value chain.

  12. MASS BALANCE: A KEY TO ADVANCING MONITORED AND ENHANCED ATTENUATION FOR CHLORINATED SOLVENTS

    Energy Technology Data Exchange (ETDEWEB)

    Looney, B; Karen Vangelas, K; Karen-M Adams, K; Francis H. Chappelle; Tom O. Early; Claire H. Sink

    2006-06-30

    Monitored natural attenuation (MNA) and enhanced attenuation (EA) are two environmental management strategies that rely on a variety of attenuation processes to degrade or immobilize contaminants and are implemented at appropriate sites by demonstrating that contaminant plumes have low risk and are stable or shrinking. The concept of a mass balance between the loading and attenuation of contaminants in a groundwater system is a powerful framework for conceptualizing and documenting the relative stability of a contaminant plume. As a result, this concept has significant potential to support appropriate implementation of monitored natural attenuation (MNA) and enhanced attenuation (EA). For mass balance to be useful in engineering practice, however, it is necessary to quantify it in practical ways that facilitate overall site remediation and which are consistent with existing regulatory guidance. Two divergent philosophies exist for quantifying plume stability--empirical and deterministic. The first relies on historical contaminant concentration data and bulk geochemical information from a monitoring well network and documents plume stability using trend analysis and statistical tools. This empirical approach, when feasible, provides powerful and compelling documentation of plume behavior and mass balance. It provides an interpretation on a relevant scale under field conditions. It integrates the operative attenuation processes measured by observing their actual impact on the plume. The power of the empirical approach was recognized early in the development of MNA guidance and protocols and it is currently the basis of the three lines of evidence used in MNA studies. The empirical approach has some weaknesses, however. It requires a relatively long period of undisturbed historical data. Thus it cannot be effectively applied to sites where active remediation was initiated quickly and is currently operating. It cannot be used as a tool to determine how much source

  13. Advances in numerical solutions to integral equations in liquid state theory

    Science.gov (United States)

    Howard, Jesse J.

    Solvent effects play a vital role in the accurate description of the free energy profile for solution phase chemical and structural processes. The inclusion of solvent effects in any meaningful theoretical model however, has proven to be a formidable task. Generally, methods involving Poisson-Boltzmann (PB) theory and molecular dynamic (MD) simulations are used, but they either fail to accurately describe the solvent effects or require an exhaustive computation effort to overcome sampling problems. An alternative to these methods are the integral equations (IEs) of liquid state theory which have become more widely applicable due to recent advancements in the theory of interaction site fluids and the numerical methods to solve the equations. In this work a new numerical method is developed based on a Newton-type scheme coupled with Picard/MDIIS routines. To extend the range of these numerical methods to large-scale data systems, the size of the Jacobian is reduced using basis functions, and the Newton steps are calculated using a GMRes solver. The method is then applied to calculate solutions to the 3D reference interaction site model (RISM) IEs of statistical mechanics, which are derived from first principles, for a solute model of a pair of parallel graphene plates at various separations in pure water. The 3D IEs are then extended to electrostatic models using an exact treatment of the long-range Coulomb interactions for negatively charged walls and DNA duplexes in aqueous electrolyte solutions to calculate the density profiles and solution thermodynamics. It is found that the 3D-IEs provide a qualitative description of the density distributions of the solvent species when compared to MD results, but at a much reduced computational effort in comparison to MD simulations. The thermodynamics of the solvated systems are also qualitatively reproduced by the IE results. The findings of this work show the IEs to be a valuable tool for the study and prediction of

  14. Integrated process for microbial solvent production from whey permeate. Final report

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-06-01

    Acetone and butanol were historically produced through fermentation of carbohydrate raw materials. Conventional feedstocks such as grain and molasses, and the energy required to recover products by distillation, are too costly for traditional batch fermentation to compete with petrochemical synthesis. The authors proposed to evaluate an acetone-butanol-ethanol fermentation of acid whey permeate, a cheap carbohydrate source, using up-to-date bioreactor technology continuous fermentation with cell recycle and in-situ butanol recovery by gas stripping. Clostridium acetobutylicum P262 was the strain chosen, as it assimilates both the lactose and lactic acid in acid whey. Single-stage continuous culture proved unsuitable for butanol production, since productivity is low and cultures degenerated quickly. Two-stage culture improved productivity by a factor of two over batch runs. All continuous cultures showed major oscillations in cell density, substrate concentration and products formed. Under these conditions, cell recycle did not affect productivity in two-stage culture. Gas stripping with fermentor off-gases recovered a clean condensate of butanol and acetone at 70--90% yield and with purification factors of 14 to 35. Stripping maintained solvent concentrations in the range of 2--4 g/l even at the peak of solventogenesis, eliminating product inhibition. Gas stripping produced a 50% improvement in substrate uptake and a 10--20% improvement in solvent productivity.

  15. Integrity evaluation for steam generator tube of system integrated modular advanced reactor

    Energy Technology Data Exchange (ETDEWEB)

    Kim, J. S.; Jin, T. E. [KOPEC, Taejon (Korea, Republic of); Jeong, M. J.; Choi, Y. H.; Jeo, J. C. [KINS, Taejon (Korea, Republic of)

    2003-10-01

    In this study, the structural integrity for SG tube of system integrated modular advanced reactor, which is subjected to dominant external pressure as well as helical type, is evaluated using the commercial finite element package ABAQUS and the American petrochemical industry code API 579 Appendix B. First of all, the crack behavior under the assumption of local heating is assessed using ABAQUS. And, the buckling behavior of tube with 40% wall thinning is assessed using API 579 Appendix B. As a result, it is found that the crack closure phenomenon occurs under external pressure and the buckling doesn't occur even if 40% wall thinning exists in tube.

  16. Integrated metrology: an enabler for advanced process control (APC)

    Science.gov (United States)

    Schneider, Claus; Pfitzner, Lothar; Ryssel, Heiner

    2001-04-01

    Advanced process control (APC) techniques become more and more important as short innovation cycles in microelectronics and a highly competitive market requires cost-effective solutions in semiconductor manufacturing. APC marks a paradigm shift from statistically based techniques (SPC) using monitor wafers for sampling measurement data towards product wafer control. The APC functionalities including run-to-run control, fault detection, and fault analysis allow to detect process drifts and excursions at an early stage and to minimize the number of misprocessed wafers. APC is being established as part of factory control systems through the definition of an APC framework. A precondition for APC is the availability of sensors and measurement methods providing the necessary wafer data. This paper discusses integrated metrology as an enabler for APC and demonstrates practical implementations in semiconductor manufacturing.

  17. Advanced multiresponse process optimisation an intelligent and integrated approach

    CERN Document Server

    Šibalija, Tatjana V

    2016-01-01

    This book presents an intelligent, integrated, problem-independent method for multiresponse process optimization. In contrast to traditional approaches, the idea of this method is to provide a unique model for the optimization of various processes, without imposition of assumptions relating to the type of process, the type and number of process parameters and responses, or interdependences among them. The presented method for experimental design of processes with multiple correlated responses is composed of three modules: an expert system that selects the experimental plan based on the orthogonal arrays; the factor effects approach, which performs processing of experimental data based on Taguchi’s quality loss function and multivariate statistical methods; and process modeling and optimization based on artificial neural networks and metaheuristic optimization algorithms. The implementation is demonstrated using four case studies relating to high-tech industries and advanced, non-conventional processes.

  18. Lime enhanced chromium removal in advanced integrated wastewater pond system.

    Science.gov (United States)

    Tadesse, I; Isoaho, S A; Green, F B; Puhakka, J A

    2006-03-01

    The removal of trivalent chromium from a combined tannery effluent in horizontal settling tanks and subsequent Advanced Integrated Wastewater Pond System (AIWPS) reactors was investigated. The raw combined effluent from Modjo tannery had pH in the range of 11.2-12. At this pH, a trivalent chromium removal of 46-72% was obtained in the horizontal settling tanks after a one-day detention time. Trivalent chromium precipitated as chromium hydroxide, Cr(OH)3. 58-95% Cr(III) was removed in the advanced facultative pond (AFP) where the water column pH of 7.2-8.4 was close to pH 8, which is the optimum precipitation pH for trivalent chromium. Chromium removals in the secondary facultative pond (SFP) and maturation pond (MP) were 30-50% and 6-16%, respectively. With Cr(III) concentration of 0.2-0.8 mg/l in the final treated effluent, the AIWPS preceded by horizontal settling tanks produced effluent that could easily meet most of the current Cr(III) discharge limits to receive water bodies.

  19. Cancer Pharmacogenomics: Integrating Discoveries in Basic, Clinical and Population Sciences to Advance Predictive Cancer Care

    Science.gov (United States)

    Cancer Pharmacogenomics: Integrating Discoveries in Basic, Clinical and Population Sciences to Advance Predictive Cancer Care, a 2010 workshop sponsored by the Epidemiology and Genomics Research Program.

  20. Integration of advanced oxidation technologies and biological processes: recent developments, trends, and advances.

    Science.gov (United States)

    Tabrizi, Gelareh Bankian; Mehrvar, Mehrab

    2004-01-01

    The greatest challenge of today's wastewater treatment technology is to optimize the use of biological and chemical wastewater treatment processes. The choice of the process and/or integration of the processes depend strongly on the wastewater characteristics, concentrations, and the desired efficiencies. It has been observed by many investigators that the coupling of a bioreactor and advanced oxidation processes (AOPs) could reduce the final concentrations of the effluent to the desired values. However, optimizing the total cost of the treatment is a challenge, as AOPs are much more expensive than biological processes alone. Therefore, an appropriate design should not only consider the ability of this coupling to reduce the concentration of organic pollutants, but also try to obtain the desired results in a cost effective process. To consider the total cost of the treatment, the residence time in biological and photochemical reactors, the kinetic rates, and the capital and operating costs of the reactors play significant roles. In this study, recent developments and trends (1996-2003) on the integration of photochemical and biological processes for the degradation of problematic pollutants in wastewater have been reviewed. The conditions to get the optimum results from this integration have also been considered. In most of the studies, it has been shown that the integrated processes were more efficient than individual processes. However, slight changes in the configuration of the reactors, temperature, pH, treatment time, concentration of the oxidants, and microorganism's colonies could lead to a great deviation in results. It has also been demonstrated that the treatment cost in both reactors is a function of time, which changes by the flow rate. The minimum cost in the coupling of the processes cannot be achieved unless considering the best treatment time in chemical and biological reactors individually.

  1. Green procedure with a green solvent for fats and oils' determination. Microwave-integrated Soxhlet using limonene followed by microwave Clevenger distillation.

    Science.gov (United States)

    Virot, Matthieu; Tomao, Valérie; Ginies, Christian; Visinoni, Franco; Chemat, Farid

    2008-07-04

    Here is described a green and original alternative procedure for fats and oils' determination in oleaginous seeds. Extractions were carried out using a by-product of the citrus industry as extraction solvent, namely d-limonene, instead of hazardous petroleum solvents such as n-hexane. The described method is achieved in two steps using microwave energy: at first, extractions are attained using microwave-integrated Soxhlet, followed by the elimination of the solvent from the medium using a microwave Clevenger distillation in the second step. Oils extracted from olive seeds were compared with both conventional Soxhlet and microwave-integrated Soxhlet extraction procedures performed with n-hexane in terms of qualitative and quantitative determination. No significant difference was obtained between each extract allowing us to conclude that the proposed method is effective and valuable.

  2. Cooperative Research and Development for Advanced Microturbines Program on Advanced Integrated Microturbine System

    Energy Technology Data Exchange (ETDEWEB)

    Michael J. Bowman

    2007-05-30

    The Advanced Integrated Microturbine Systems (AIMS) project was kicked off in October of 2000 to develop the next generation microturbine system. The overall objective of the project was to develop a design for a 40% electrical efficiency microturbine system and demonstrate many of the enabling technologies. The project was initiated as a collaborative effort between several units of GE, Elliott Energy Systems, Turbo Genset, Oak Ridge National Lab and Kyocera. Since the inception of the project the partners have changed but the overall direction of the project has stayed consistent. The project began as a systems study to identify design options to achieve the ultimate goal of 40% electrical efficiency. Once the optimized analytical design was identified for the 40% system, it was determined that a 35% efficient machine would be capable of demonstrating many of the advanced technologies within the given budget and timeframe. The items that would not be experimentally demonstrated were fully produced ceramic parts. However, to understand the requirements of these ceramics, an effort was included in the project to experimentally evaluate candidate materials in representative conditions. The results from this effort would clearly identify the challenges and improvement required of these materials for the full design. Following the analytical effort, the project was dedicated to component development and testing. Each component and subsystem was designed with the overall system requirements in mind and each tested to the fullest extent possible prior to being integrated together. This method of component development and evaluation helps to minimize the technical risk of the project. Once all of the components were completed, they were assembled into the full system and experimentally evaluated.

  3. Integration of advanced teleoperation technologies for control of space robots

    Science.gov (United States)

    Stagnaro, Michael J.

    1993-01-01

    Teleoperated robots require one or more humans to control actuators, mechanisms, and other robot equipment given feedback from onboard sensors. To accomplish this task, the human or humans require some form of control station. Desirable features of such a control station include operation by a single human, comfort, and natural human interfaces (visual, audio, motion, tactile, etc.). These interfaces should work to maximize performance of the human/robot system by streamlining the link between human brain and robot equipment. This paper describes development of a control station testbed with the characteristics described above. Initially, this testbed will be used to control two teleoperated robots. Features of the robots include anthropomorphic mechanisms, slaving to the testbed, and delivery of sensory feedback to the testbed. The testbed will make use of technologies such as helmet mounted displays, voice recognition, and exoskeleton masters. It will allow tor integration and testing of emerging telepresence technologies along with techniques for coping with control link time delays. Systems developed from this testbed could be applied to ground control of space based robots. During man-tended operations, the Space Station Freedom may benefit from ground control of IVA or EVA robots with science or maintenance tasks. Planetary exploration may also find advanced teleoperation systems to be very useful.

  4. Integrated Refrigeration and Storage for Advanced Liquid Hydrogen Operations

    Science.gov (United States)

    Swanger, A. M.; Notardonato, W. U.; Johnson, W. L.; Tomsik, T. M.

    2016-01-01

    NASA has used liquefied hydrogen (LH2) on a large scale since the beginning of the space program as fuel for the Centaur and Apollo upper stages, and more recently to feed the three space shuttle main engines. The LH2 systems currently in place at the Kennedy Space Center (KSC) launch pads are aging and inefficient compared to the state-of-the-art. Therefore, the need exists to explore advanced technologies and operations that can drive commodity costs down, and provide increased capabilities. The Ground Operations Demonstration Unit for Liquid Hydrogen (GODU-LH2) was developed at KSC to pursue these goals by demonstrating active thermal control of the propellant state by direct removal of heat using a cryocooler. The project has multiple objectives including zero loss storage and transfer, liquefaction of gaseous hydrogen, and densification of liquid hydrogen. The key technology challenge was efficiently integrating the cryogenic refrigerator into the LH2 storage tank. A Linde LR1620 Brayton cycle refrigerator is used to produce up to 900W cooling at 20K, circulating approximately 22 g/s gaseous helium through the hydrogen via approximately 300 m of heat exchanger tubing. The GODU-LH2 system is fully operational, and is currently under test. This paper will discuss the design features of the refrigerator and storage system, as well as the current test results.

  5. Advancements in Wind Integration Study Input Data Modeling: The Wind Integration National Dataset (WIND) Toolkit

    Science.gov (United States)

    Hodge, B.; Orwig, K.; McCaa, J. R.; Harrold, S.; Draxl, C.; Jones, W.; Searight, K.; Getman, D.

    2013-12-01

    projects to develop updated datasets: the Wind Integration National Dataset (WIND) Toolkit and the Solar Integration National Dataset (SIND) Toolkit. The WIND Toolkit spans 2007-2013 using advanced NWP methods run on a nationwide 2-km grid with 5-minute resolution, and includes over 110,000 onshore and offshore wind power production sites. This paper and presentation will discuss an overview of the WIND Toolkit modeling advancements, site selection, data accessibility, and validation results.

  6. United by Goals: There Is No Integrated Advancement without Communications and Marketing

    Science.gov (United States)

    DiConsiglio, John

    2011-01-01

    The idea behind integrated advancement is simple and dates back to the 1990s: A strong relationship between advancement offices conserves resources. It leads to a more efficient workforce. It portrays a highly unified message to stakeholders, including donors, alumni, local officials, and opinion leaders. In short, the entire advancement team…

  7. ADVANCE IN SOLVENTS OF CHITIN AND ITS APPLICATION%甲壳素良溶剂及其应用

    Institute of Scientific and Technical Information of China (English)

    刘廷国; 查萍萍; 李斌

    2011-01-01

    甲壳素是一种非常重要的高附加值生物质资源,由于无法溶于水、稀酸、稀碱和一般的有机溶剂,极大地限制了其广泛应用.目前寻找合适的甲壳素良溶剂仍是一个非常具有挑战性的课题.国内外文献中尚无专门的甲壳素溶剂方面的综述文章.本文综述了甲壳素的常用良溶剂,包括无机盐、浓酸、浓碱、氟化试剂和酰胺/氯化锂等溶剂.期望为甲壳素的深入研究和利用提供基础的文献参考.%Chitin is the second most abundant natural biopolymer on earth after cellulose, which is regarded as a high value-added biomass resource. However, it is insoluble in water, diluted acid, alkaline solution, and common organic solvents, due to the existence of strong intra- and inter- molecular hydrogen bonds. This strongly restricts many applications of chitin in many fields. Therefore, it is still a challenging study for searching better chitin solvents. In the literature, there are no special review articles for chitin solvent. This paper reviews the common good solvent of chitin, such as inorganic salts, concentrated acids or alkaline solutions, fluorinated solvents and amide/LiCl systems, and so on. Which is expected to provide a basic literature reference for further research and utilization of chitin.

  8. On the Integration Role of Solvents in Process Synthesis-Design-Intensification: Application to DMC/MeOH separation

    DEFF Research Database (Denmark)

    Gani, Rafiqul; Babi, Deenesh Kavi

    2015-01-01

    and the heavier boiling compound is obtained as the top product of the second distillation column where the solvent is recovered (for re-use and recycle). Therefore, the solvent design problem can be defined as follows, given an azeotropic mixture to be separated into two pure streams that utilizes a mass...... separating agent, find the best (optimal or near-optimal) solvent candidate (or mixture) that can perform the separation subject to economic, environmental and thermo-physical property constraints. This design problem inherently is a mixed integer non-linear programming problem because the property...... design problem into manageable sub-problems. In the first stage, a number of solvent candidates are generated based on pre-defined structural constraints, for example, acyclic, cyclic and/or aromatic compounds, etc. In the second stage, the solvent candidates are screened using property constraints...

  9. Energy Systems Integration: NREL + Advanced Energy (Fact Sheet)

    Energy Technology Data Exchange (ETDEWEB)

    2015-02-01

    This fact sheet describes the collaboration between NREL and Advanced Energy Industries at the ESIF to test its advanced photovoltaic inverter technology with the ESIF's power hardware-in-the-loop system and megawatt-scale grid simulators.

  10. Grid Integration Studies: Advancing Clean Energy Planning and Deployment

    Energy Technology Data Exchange (ETDEWEB)

    Katz, Jessica [National Renewable Energy Lab. (NREL), Golden, CO (United States); Chernyakhovskiy, Ilya [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2016-07-01

    Integrating significant variable renewable energy (VRE) into the grid requires an evolution in power system planning and operation. To plan for this evolution, power system stakeholders can undertake grid integration studies. This Greening the Grid document reviews grid integration studies, common elements, questions, and guidance for system planners.

  11. Integration of continuous production and recovery of solvents from whey permeate: Use of immobilized cells of Clostridium acetobutylicum in a fluidized bed reactor coupled with gas stripping

    Energy Technology Data Exchange (ETDEWEB)

    Qureshi, N.; Maddox, I.S. (Massey Univ., Palmerston North (New Zealand). Biotechnology Dept.)

    1991-01-01

    An investigation was performed into the operation of an integrated system for continuous production and product recovery of solvents (acetone-butanol-ethanol) from the ABE fermentation process. Cells of Clostridium acetobutylicum were immobilized by adsorption onto bonechar, and used in a fluidized bed reactor for continuous solvent production from whey permeate. The reactor effluent was stripped of the solvents using nitrogen gas, and was recycled to the reactor. This relieved product inhibition and allowed further sugar utilization. At a dilution rate of 1.37 h{sup -1} a reactor productivity of 5.1 kg/(cm{sup 3}xh) was achieved. The solvents in the stripping gas were condensed to give a solution of 53.7 kg/m{sup 3}. This system has the advantages of relieving product inhibition, and providing a more concentrated solution for recovery by distillation. Residual sugar and non-volatile reaction intermediate are not removed by gas stripping and this contributes to high solvent yields. (orig.).

  12. Advances in Research on Hepatitis B Virus DNA Integration

    Institute of Scientific and Technical Information of China (English)

    Ju-sheng LIN; Lin-lin GAO

    2008-01-01

    Since HBV DNA integration was discovered for the first time in 1980, various methods have been used to detect and study it, such as Southern Blot, in situ hybridization, polymerase chain reaction and so on. HBV DNA integration is thought to be random on the whole although some hot spots of integration were described by some researchers, one of which might be the repetitive sequences of the genomic DNA. Besides, DNA damage, especially double-strand breaks could promote HBV DNA integration into host genome. HBV DNA integration into cells may damage the stability of the genome, cause DNA rearrangement, promote DNA deletion and induce the formation of HCC.

  13. EXPODE -- Advanced Exponential Time Integration Toolbox for MATLAB

    OpenAIRE

    2014-01-01

    We present a MATLAB toolbox for five different classes of exponential integrators for solving (mildly) stiff ordinary differential equations or time-dependent partial differential equations. For the efficiency of such exponential integrators it is essential to approximate the products of the matrix functions arising in these integrators with vectors in a stable, reliable and efficient way. The toolbox contains options for computing the matrix functions directly by diagonalization or by Pade a...

  14. Advanced solvent based methods for molecular characterization of soil organic matter by high-resolution mass spectrometry

    Energy Technology Data Exchange (ETDEWEB)

    Tfaily, Malak M.; Chu, Rosalie K.; Tolic, Nikola; Roscioli, Kristyn M.; Anderton, Christopher R.; Pasa-Tolic, Ljiljana; Robinson, Errol W.; Hess, Nancy J.

    2015-05-19

    Soil organic matter (SOM) a complex, heterogeneous mixture of above and belowground plant litter and animal and microbial residues at various degrees of decomposition, is a key reservoir for carbon (C) and nutrient biogeochemical cycling in soil based ecosystems. A limited understanding of the molecular composition of SOM limits the ability to routinely decipher chemical processes within soil and predict accurately how terrestrial carbon fluxes will response to changing climatic conditions and land use. To elucidate the molecular-level structure of SOM, we selectively extracted a broad range of intact SOM compounds by a combination of different organic solvents from soils with a wide range of C content. Our use of Electrospray ionization (ESI) coupled with Fourier transform ion cyclotron resonance mass spectrometry (FTICR MS) and a suite of solvents with varying polarity significantly expands the inventory of the types of organic molecules present in soils. Specifically, we found that hexane is selective for lipid-like compounds with very low O:C ratios; water was selective for carbohydrates with high O:C ratios; acetonitrile preferentially extracts lignin, condensed structures, and tannin poly phenolic compounds with O:C > 0.5; methanol has higher selectivity towards compounds characterized with low O:C < 0.5; and hexane, MeOH, ACN and water solvents increase the number and types of organic molecules extracted from soil for a broader range of chemically diverse soil types. Our study of SOM molecules by ESI-FTICR MS revealed new insight into the molecular-level complexity of organics contained in soils.

  15. Advanced computer algebra algorithms for the expansion of Feynman integrals

    Energy Technology Data Exchange (ETDEWEB)

    Ablinger, Jakob; Round, Mark; Schneider, Carsten [Johannes Kepler Univ., Linz (Austria). Research Inst. for Symbolic Computation; Bluemlein, Johannes [Deutsches Elektronen-Synchrotron (DESY), Zeuthen (Germany)

    2012-10-15

    Two-point Feynman parameter integrals, with at most one mass and containing local operator insertions in 4+{epsilon}-dimensional Minkowski space, can be transformed to multi-integrals or multi-sums over hyperexponential and/or hypergeometric functions depending on a discrete parameter n. Given such a specific representation, we utilize an enhanced version of the multivariate Almkvist-Zeilberger algorithm (for multi-integrals) and a common summation framework of the holonomic and difference field approach (for multi-sums) to calculate recurrence relations in n. Finally, solving the recurrence we can decide efficiently if the first coefficients of the Laurent series expansion of a given Feynman integral can be expressed in terms of indefinite nested sums and products; if yes, the all n solution is returned in compact representations, i.e., no algebraic relations exist among the occurring sums and products.

  16. Advanced Computer Algebra Algorithms for the Expansion of Feynman Integrals

    CERN Document Server

    Ablinger, J; Round, M; Schneider, C

    2012-01-01

    Two-point Feynman parameter integrals, with at most one mass and containing local operator insertions in $4+\\ep$-dimensional Minkowski space, can be transformed to multi-integrals or multi-sums over hyperexponential and/or hypergeometric functions depending on a discrete parameter $n$. Given such a specific representation, we utilize an enhanced version of the multivariate Almkvist--Zeilberger algorithm (for multi-integrals) and a common summation framework of the holonomic and difference field approach (for multi-sums) to calculate recurrence relations in $n$. Finally, solving the recurrence we can decide efficiently if the first coefficients of the Laurent series expansion of a given Feynman integral can be expressed in terms of indefinite nested sums and products; if yes, the all $n$ solution is returned in compact representations, i.e., no algebraic relations exist among the occurring sums and products.

  17. Advancing Integrated Systems Modelling Framework for Life Cycle Sustainability Assessment

    Directory of Open Access Journals (Sweden)

    Anthony Halog

    2011-02-01

    Full Text Available The need for integrated methodological framework for sustainability assessment has been widely discussed and is urgent due to increasingly complex environmental system problems. These problems have impacts on ecosystems and human well-being which represent a threat to economic performance of countries and corporations. Integrated assessment crosses issues; spans spatial and temporal scales; looks forward and backward; and incorporates multi-stakeholder inputs. This study aims to develop an integrated methodology by capitalizing the complementary strengths of different methods used by industrial ecologists and biophysical economists. The computational methodology proposed here is systems perspective, integrative, and holistic approach for sustainability assessment which attempts to link basic science and technology to policy formulation. The framework adopts life cycle thinking methods—LCA, LCC, and SLCA; stakeholders analysis supported by multi-criteria decision analysis (MCDA; and dynamic system modelling. Following Pareto principle, the critical sustainability criteria, indicators and metrics (i.e., hotspots can be identified and further modelled using system dynamics or agent based modelling and improved by data envelopment analysis (DEA and sustainability network theory (SNT. The framework is being applied to development of biofuel supply chain networks. The framework can provide new ways of integrating knowledge across the divides between social and natural sciences as well as between critical and problem-solving research.

  18. Silicon integrated circuits advances in materials and device research

    CERN Document Server

    Kahng, Dawon

    1981-01-01

    Silicon Integrated Circuits, Part B covers the special considerations needed to achieve high-power Si-integrated circuits. The book presents articles about the most important operations needed for the high-power circuitry, namely impurity diffusion and oxidation; crystal defects under thermal equilibrium in silicon and the development of high-power device physics; and associated technology. The text also describes the ever-evolving processing technology and the most promising approaches, along with the understanding of processing-related areas of physics and chemistry. Physicists, chemists, an

  19. Academic Integration Supplement to the Advanced Food Science and Nutrition Curriculum Guide.

    Science.gov (United States)

    Texas Tech Univ., Lubbock. Home Economics Curriculum Center.

    This supplement to an advanced food science and nutrition curriculum guide was developed for use in integrating academic principles with vocational home economics education in Texas. It contains learning and evaluation experiences specifically designed to integrate mathematics, science, language arts, and social studies principles within the…

  20. Recent advances in tailoring the aggregation of heavier alkaline earth metal halides, alkoxides and aryloxides from non-aqueous solvents.

    Science.gov (United States)

    Fromm, Katharina M

    2006-11-21

    This overview on one of the subjects treated in our group deals with the synthesis and study of low-dimensional polymer and molecular solid state structures formed with alkaline earth metal ions in non-aqueous solvents. We have chosen several synthetic approaches in order to obtain such compounds. The first concept deals with the "cutting out" of structural fragments from a solid state structure of a binary compound, which will be explained with reference to BaI2. Depending on the size and concentration of oxygen donor ligands, used as chemical scissors on BaI2, three-, two-, one- and zero-dimensional derived adducts of BaI2 are obtained, comparable to a structural genealogy tree for BaI2. A second part deals with the supramolecular approach for the synthesis of low dimensional polymeric compounds based on alkaline earth metal iodides, obtained by the combination of metal ion coordination with hydrogen bonding between the cationic complexes and their anions. Certain circumstances allow rules to be established for the prediction of the dimensionality of a given compound, contributing to the fundamental problem of structure prediction in crystal engineering. A third section describes a synthetic approach for generating pure alkaline earth metal cage compounds as well as alkali and alkaline earth mixed metal clusters. A first step deals with different molecular solvated alkaline earth metal iodides which are investigated as a function of the ligand size in non-aqueous solvents. These are then reacted with some alkali metal compound in order to partially or totally eliminate alkali iodide and to form the targeted clusters. These unique structures of ligand stabilized metal halide, hydroxide and/or alkoxide and aryloxide aggregates are of interest as potential precursors for oxide materials and as catalysts. Approaches to two synthetic methods of the latter, sol-gel and (MO)CVD (metal-organic chemical vapour deposition), are investigated with some of our compounds. (D

  1. Universal Plug-n-Play Sensor Integration for Advanced Navigation

    Science.gov (United States)

    2012-03-22

    noticed due to trial and error was that the SICK, which is attached to the PowerBot and connected to the motherboard with the aid of a dedicated...be specific to MobileRobots’s robots in particular. For the PowerBot, there is a laser integration board that is connected to the motherboard within

  2. System design and control integration for advanced manufacturing

    CERN Document Server

    Li, Han-Xiong

    2014-01-01

    Most existing robust design books address design for static systems, or achieve robust design from experimental data via the Taguchi method. Little work considers model information for robust design particularly for the dynamic system. This book covers robust design for both static and dynamic systems using the nominal model information or the hybrid model/data information, and also integrates design with control under a large operating region. This design can handle strong nonlinearity and more uncertainties from model and parameters.

  3. Integrated Modeling of Advanced Opto-Mechanical Systems

    Science.gov (United States)

    Briggs, Hugh C.; Phillips, Charles J.; Orzewalla, Mathew A.

    2006-01-01

    The design of optical hardware for space applications is particularly challenging when developing high performance, novel systems that have no precedent. Integrated modeling and analysis of such opto-mechanical systems seeks to describe the end-to-end performance of the hardware using mission-relevant metrics. This multidisciplinary analysis might start with thermal disturbances from observation maneuvers, compute the system temperatures, compute the distorted positions and shapes of the hardware and compute the resulting optical performance. Dynamic disturbances such as reaction wheel imbalance or inertia imbalance of optical delay lines might be applied to a structural dynamic model and used in a guidance and control analysis. Mission-relevant science metrics might include wavefront quality, pointing error or imaging stability. Assembling a tool chain that can be both nimble and effective when scaled to the high fidelity models of detail design has been challenging. An integrated thermal, mechanical and optical analysis capability suitable for detail design has been developed and verified through experimental measurement. This capability was used in the design of flight-like breadboard hardware and development of a test apparatus that established both the level of performance of the hardware and the validity of the analysis. The analysis includes prediction of the thermal environment of the test chamber, detailed temperature distributions on the breadboard hardware, fine scale deformations of the optical elements, and computation of the wavefront quality using geometric optics. A battery of tests were conducted to assess the experiment data acquisition, measurement and control system and to establish the performance of the hardware design and accuracy of the integrated modeling. Thermal loads that represent operational observing maneuvers were imposed and the hardware optical performance was measured and compared to analytical predictions.

  4. Research on Visual Display Integration for Advanced Fighter Aircraft.

    Science.gov (United States)

    1978-11-01

    516 Unclassified St. Louis, Mo. 63166 Isa . DECLA SSIFICATIO N/DOW NGRAOING SCH EDULE I~~~~~iSTRI BUTION STATEMENT (of eM. R.port) Approved for public...Correlator RH Relative Humidity RHAWS Radar Homing and Warning System ROE Rules of Engagement RPM Revolutions per Minute RTU Remote Terminal Unit SAN...ipment BCIU , RTU Integrated within sensor or processor Fêqur. 20 Tsdino$o.y Advsncss Av•ilabls for Mid-1980s DAIS 39 p - ‘ - .- ‘~~~~.-1?;- - . 4.ft

  5. Ceramic Integration Technologies for Advanced Energy Systems: Critical Needs, Technical Challenges, and Opportunities

    Science.gov (United States)

    Singh, Mrityunjay

    2010-01-01

    Advanced ceramic integration technologies dramatically impact the energy landscape due to wide scale application of ceramics in all aspects of alternative energy production, storage, distribution, conservation, and efficiency. Examples include fuel cells, thermoelectrics, photovoltaics, gas turbine propulsion systems, distribution and transmission systems based on superconductors, nuclear power generation and waste disposal. Ceramic integration technologies play a key role in fabrication and manufacturing of large and complex shaped parts with multifunctional properties. However, the development of robust and reliable integrated systems with optimum performance requires the understanding of many thermochemical and thermomechanical factors, particularly for high temperature applications. In this presentation, various needs, challenges, and opportunities in design, fabrication, and testing of integrated similar (ceramic ceramic) and dissimilar (ceramic metal) material www.nasa.gov 45 ceramic-ceramic-systems have been discussed. Experimental results for bonding and integration of SiC based Micro-Electro-Mechanical-Systems (MEMS) LDI fuel injector and advanced ceramics and composites for gas turbine applications are presented.

  6. Glycerol based solvents: synthesis, properties and applications

    OpenAIRE

    García, José I.; García-Marín, Héctor; Pires, Elísabet

    2014-01-01

    The most recent advances in the use of glycerol and glycerol derivatives as solvents are reviewed. There are an increasing number of examples of the use of glycerol itself as a reaction medium, solvent-reagent or a dispersive medium for a large variety of applications. In the case of glycerol derivatives, new synthetic methods, physico-chemical properties and application examples as solvents are revised. Recent studies in the field of solvent classification, as well as solvent substitution is...

  7. Advancing population ecology with integral projection models: a practical guide

    DEFF Research Database (Denmark)

    Merow, Cory; Dahlgren, Johan; Metcall, C. Jessica E.;

    2014-01-01

    (e.g., environment). By combining regressions of vital rates, an IPM provides mechanistic insight into emergent ecological patterns such as population dynamics, species geographic distributions, or life history strategies. Here, we review important resources for building IPMs and provide......Integral Projection Models (IPMs) use information on how an individual's state influences its vital rates - survival, growth and reproduction - to make population projections. IPMs are constructed from regression models predicting vital rates from state variables (e.g., size or age) and covariates...... a comprehensive guide, with extensive R code, for their construction. IPMs can be applied to any stage-structured population; here we illustrate IPMs for a series of plant life histories of increasing complexity and biological realism, highlighting the utility of various regression methods for capturing...

  8. Advancing the integration of history and ecology for conservation.

    Science.gov (United States)

    Szabó, Péter; Hédl, Radim

    2011-08-01

    The important role of humans in the development of current ecosystems was recognized decades ago; however, the integration of history and ecology in order to inform conservation has been difficult. We identified four issues that hinder historical ecological research and considered possible solutions. First, differences in concepts and methods between the fields of ecology and history are thought to be large. However, most differences stem from miscommunication between ecologists and historians and are less substantial than is usually assumed. Cooperation can be achieved by focusing on the features ecology and history have in common and through understanding and acceptance of differing points of view. Second, historical ecological research is often hampered by differences in spatial and temporal scales between ecology and history. We argue that historical ecological research can only be conducted at extents for which sources in both disciplines have comparable resolutions. Researchers must begin by clearly defining the relevant scales for the given purpose. Third, periods for which quantitative historical sources are not easily accessible (before AD 1800) have been neglected in historical ecological research. Because data from periods before 1800 are as relevant to the current state of ecosystems as more recent data, we suggest that historical ecologists actively seek out data from before 1800 and apply analytic methods commonly used in ecology to these data. Fourth, humans are not usually considered an intrinsic ecological factor in current ecological research. In our view, human societies should be acknowledged as integral parts of ecosystems and societal processes should be recognized as driving forces of ecosystem change.

  9. V5 AND V10 CONTACTOR TESTING WITH THE NEXT GENERATION (CSSX) SOLVENT FOR THE SAVANNAH RIVER SITE INTEGRATED SALT DISPOSITION PROCESS

    Energy Technology Data Exchange (ETDEWEB)

    Restivo, M.; Peters, T.; Pierce, R.; Fondeur, F.; Steeper, T.; Williams, M.; Giddings, B.; Hickman, B.; Fink, S.

    2012-01-17

    A solvent extraction system for removal of cesium (Cs) from alkaline solutions was developed utilizing a novel solvent invented at the Oak Ridge National Laboratory (ORNL). This solvent consists of a calix[4]arene-crown-6 extractant dissolved in an inert hydrocarbon matrix. A Modifier is added to the solvent to enhance the extraction power of the calixarene and to prevent the formation of a third phase. An additional additive, called a suppressor, is used to improve stripping performance. The process that deploys this solvent system is known as Caustic Side Solvent Extraction (CSSX). The solvent system has been deployed at the Savannah River Site (SRS) in the Modular CSSX Unit (MCU) since 2008. Subsequent development efforts by ORNL identified an improved solvent system that can raise the expected decontamination factor (DF) in MCU from {approx}200 to more than 40,000. The improved DF is attributed to an improved distribution ratio for cesium [D(Cs)] in extraction from {approx}15 to {approx}60, an increased solubility of the calixarene in the solvent from 0.007 M to >0.050 M, and use of boric acid (H{sub 3}BO{sub 3}) stripping that also yields improved D(Cs) values. Additionally, the changes incorporated into the Next Generation CSSX Solvent (NGS) are intended to reduce solvent entrainment by virtue of more favorable physical properties. The MCU and Salt Waste Processing Facility (SWPF) facilities are actively pursuing the changeover from the current CSSX solvent to the NGS solvent. To support this integration of the NGS into the MCU and SWPF facilities, the Savannah River Remediation (SRR)/ARP/MCU Life Extension Project requested that the Savannah River National Laboratory (SRNL) perform testing of the new solvent for the removal of Cs from the liquid salt waste stream. Additionally, SRNL was tasked with characterizing both strip (20-in long, 10 micron pore size) and extraction (40-in long, 20 micron pore size) coalescers. SRNL designed a pilot-scale experimental

  10. V5 AND V10 CONTACTOR TESTING WITH THE NEXT GENERATION (CSSX) SOLVENT FOR THE SAVANNAH RIVER SITE INTEGRATED SALT DISPOSITION PROCESS

    Energy Technology Data Exchange (ETDEWEB)

    Restivo, M.; Peters, T.; Pierce, R.; Fondeur, F.; Steeper, T.; Williams, M.; Giddings, B.; Hickman, B.; Fink, S.

    2012-01-17

    A solvent extraction system for removal of cesium (Cs) from alkaline solutions was developed utilizing a novel solvent invented at the Oak Ridge National Laboratory (ORNL). This solvent consists of a calix[4]arene-crown-6 extractant dissolved in an inert hydrocarbon matrix. A Modifier is added to the solvent to enhance the extraction power of the calixarene and to prevent the formation of a third phase. An additional additive, called a suppressor, is used to improve stripping performance. The process that deploys this solvent system is known as Caustic Side Solvent Extraction (CSSX). The solvent system has been deployed at the Savannah River Site (SRS) in the Modular CSSX Unit (MCU) since 2008. Subsequent development efforts by ORNL identified an improved solvent system that can raise the expected decontamination factor (DF) in MCU from {approx}200 to more than 40,000. The improved DF is attributed to an improved distribution ratio for cesium [D(Cs)] in extraction from {approx}15 to {approx}60, an increased solubility of the calixarene in the solvent from 0.007 M to >0.050 M, and use of boric acid (H{sub 3}BO{sub 3}) stripping that also yields improved D(Cs) values. Additionally, the changes incorporated into the Next Generation CSSX Solvent (NGS) are intended to reduce solvent entrainment by virtue of more favorable physical properties. The MCU and Salt Waste Processing Facility (SWPF) facilities are actively pursuing the changeover from the current CSSX solvent to the NGS solvent. To support this integration of the NGS into the MCU and SWPF facilities, the Savannah River Remediation (SRR)/ARP/MCU Life Extension Project requested that the Savannah River National Laboratory (SRNL) perform testing of the new solvent for the removal of Cs from the liquid salt waste stream. Additionally, SRNL was tasked with characterizing both strip (20-in long, 10 micron pore size) and extraction (40-in long, 20 micron pore size) coalescers. SRNL designed a pilot-scale experimental

  11. Advanced Model Compounds for Understanding Acid-Catalyzed Lignin Depolymerization: Identification of Renewable Aromatics and a Lignin-Derived Solvent.

    Science.gov (United States)

    Lahive, Ciaran W; Deuss, Peter J; Lancefield, Christopher S; Sun, Zhuohua; Cordes, David B; Young, Claire M; Tran, Fanny; Slawin, Alexandra M Z; de Vries, Johannes G; Kamer, Paul C J; Westwood, Nicholas J; Barta, Katalin

    2016-07-20

    The development of fundamentally new approaches for lignin depolymerization is challenged by the complexity of this aromatic biopolymer. While overly simplified model compounds often lack relevance to the chemistry of lignin, the direct use of lignin streams poses significant analytical challenges to methodology development. Ideally, new methods should be tested on model compounds that are complex enough to mirror the structural diversity in lignin but still of sufficiently low molecular weight to enable facile analysis. In this contribution, we present a new class of advanced (β-O-4)-(β-5) dilinkage models that are highly realistic representations of a lignin fragment. Together with selected β-O-4, β-5, and β-β structures, these compounds provide a detailed understanding of the reactivity of various types of lignin linkages in acid catalysis in conjunction with stabilization of reactive intermediates using ethylene glycol. The use of these new models has allowed for identification of novel reaction pathways and intermediates and led to the characterization of new dimeric products in subsequent lignin depolymerization studies. The excellent correlation between model and lignin experiments highlights the relevance of this new class of model compounds for broader use in catalysis studies. Only by understanding the reactivity of the linkages in lignin at this level of detail can fully optimized lignin depolymerization strategies be developed.

  12. AN ADVANCED TOOL FOR APPLIED INTEGRATED SAFETY MANAGEMENT

    Energy Technology Data Exchange (ETDEWEB)

    Potts, T. Todd; Hylko, James M.; Douglas, Terence A.

    2003-02-27

    WESKEM, LLC's Environmental, Safety and Health (ES&H) Department had previously assessed that a lack of consistency, poor communication and using antiquated communication tools could result in varying operating practices, as well as a failure to capture and disseminate appropriate Integrated Safety Management (ISM) information. To address these issues, the ES&H Department established an Activity Hazard Review (AHR)/Activity Hazard Analysis (AHA) process for systematically identifying, assessing, and controlling hazards associated with project work activities during work planning and execution. Depending on the scope of a project, information from field walkdowns and table-top meetings are collected on an AHR form. The AHA then documents the potential failure and consequence scenarios for a particular hazard. Also, the AHA recommends whether the type of mitigation appears appropriate or whether additional controls should be implemented. Since the application is web based, the information is captured into a single system and organized according to the >200 work activities already recorded in the database. Using the streamlined AHA method improved cycle time from over four hours to an average of one hour, allowing more time to analyze unique hazards and develop appropriate controls. Also, the enhanced configuration control created a readily available AHA library to research and utilize along with standardizing hazard analysis and control selection across four separate work sites located in Kentucky and Tennessee. The AHR/AHA system provides an applied example of how the ISM concept evolved into a standardized field-deployed tool yielding considerable efficiency gains in project planning and resource utilization. Employee safety is preserved through detailed planning that now requires only a portion of the time previously necessary. The available resources can then be applied to implementing appropriate engineering, administrative and personal protective equipment

  13. Multi-Purpose Thermal Hydraulic Loop: Advanced Reactor Technology Integral System Test (ARTIST) Facility for Support of Advanced Reactor Technologies

    Energy Technology Data Exchange (ETDEWEB)

    James E. O' Brien; Piyush Sabharwall; SuJong Yoon

    2001-11-01

    Effective and robust high temperature heat transfer systems are fundamental to the successful deployment of advanced reactors for both power generation and non-electric applications. Plant designs often include an intermediate heat transfer loop (IHTL) with heat exchangers at either end to deliver thermal energy to the application while providing isolation of the primary reactor system. In order to address technical feasibility concerns and challenges a new high-temperature multi-fluid, multi-loop test facility “Advanced Reactor Technology Integral System Test facility” (ARTIST) is under development at the Idaho National Laboratory. The facility will include three flow loops: high-temperature helium, molten salt, and steam/water. Details of some of the design aspects and challenges of this facility, which is currently in the conceptual design phase, are discussed

  14. Steam and solvent injection as an advanced recovering method for heavy oil reservoirs; Injecao de vapor e solvente como um metodo de recuperacao avancada em reservatorios de oleo pesado

    Energy Technology Data Exchange (ETDEWEB)

    Galvao, Edney Rafael V.P.; Rodrigues, Marcos Allyson F.; Barbosa, Janaina Medeiros D.; Barillas, Jennys Lourdes M.; Dutra Junior, Tarcilio V.; Mata, Wilson da [Universidade Federal do Rio Grande do Norte (UFRN), Natal, RN (Brazil)

    2008-07-01

    Currently a resource more and more used by the petroleum industry to increase the efficiency of steam flood mechanism is the addition of solvents. The process can be understood as a combination of a thermal method (steam injection) with a miscible method (solvent injection), promoting, thus, the reduction of interfacial tensions and oil viscosity. The mobility of the displaced fluid is then improved, resulting in an increase of oil recovery. To better understand this improved oil recovery method, a numerical study of the process was driven contemplating the effects of some operational parameters (distance between wells, injection fluids rate, kind of solvent and injected solvent volume) on the accumulated production of oil and recovery factor. Semisynthetic models were used in this study but reservoir data can be extrapolated for practical applications situations on Potiguar Basin. Simulations were performed in STARS (CMG, 2007.11). It was found that injected solvent volumes increased oil recovery and oil rates. Further the majority of the injected solvent was produced and can be recycled. (author)

  15. Solvent substitution

    Energy Technology Data Exchange (ETDEWEB)

    1990-01-01

    The DOE Environmental Restoration and Waste Management Office of Technology Development and the Air Force Engineering and Services Center convened the First Annual International Workshop on Solvent Substitution on December 4--7, 1990. The primary objectives of this joint effort were to share information and ideas among attendees in order to enhance the development and implementation of required new technologies for the elimination of pollutants associated with industrial use of hazardous and toxic solvents; and to aid in accelerating collaborative efforts and technology transfer between government and industry for solvent substitution. There were workshop sessions focusing on Alternative Technologies, Alternative Solvents, Recovery/Recycling, Low VOC Materials and Treatment for Environmentally Safe Disposal. The 35 invited papers presented covered a wide range of solvent substitution activities including: hardware and weapons production and maintenance, paint stripping, coating applications, printed circuit boards, metal cleaning, metal finishing, manufacturing, compliance monitoring and process control monitoring. This publication includes the majority of these presentations. In addition, in order to further facilitate information exchange and technology transfer, the US Air Force and DOE solicited additional papers under a general Call for Papers.'' These papers, which underwent review and final selection by a peer review committee, are also included in this combined Proceedings/Compendium. For those involved in handling, using or managing hazardous and toxic solvents, this document should prove to be a valuable resource, providing the most up-to-date information on current technologies and practices in solvent substitution. Individual papers are abstracted separated.

  16. Systems Engineering and Integration for Advanced Life Support System and HST

    Science.gov (United States)

    Kamarani, Ali K.

    2005-01-01

    Systems engineering (SE) discipline has revolutionized the way engineers and managers think about solving issues related to design of complex systems: With continued development of state-of-the-art technologies, systems are becoming more complex and therefore, a systematic approach is essential to control and manage their integrated design and development. This complexity is driven from integration issues. In this case, subsystems must interact with one another in order to achieve integration objectives, and also achieve the overall system's required performance. Systems engineering process addresses these issues at multiple levels. It is a technology and management process dedicated to controlling all aspects of system life cycle to assure integration at all levels. The Advanced Integration Matrix (AIM) project serves as the systems engineering and integration function for the Human Support Technology (HST) program. AIM provides means for integrated test facilities and personnel for performance trade studies, analyses, integrated models, test results, and validated requirements of the integration of HST. The goal of AIM is to address systems-level integration issues for exploration missions. It will use an incremental systems integration approach to yield technologies, baselines for further development, and possible breakthrough concepts in the areas of technological and organizational interfaces, total information flow, system wide controls, technical synergism, mission operations protocols and procedures, and human-machine interfaces.

  17. Using the Student Research Project to Integrate Macroeconomics and Statistics in an Advanced Cost Accounting Course

    Science.gov (United States)

    Hassan, Mahamood M.; Schwartz, Bill N.

    2014-01-01

    This paper discusses a student research project that is part of an advanced cost accounting class. The project emphasizes active learning, integrates cost accounting with macroeconomics and statistics by "learning by doing" using real world data. Students analyze sales data for a publicly listed company by focusing on the company's…

  18. Effects of the Integrated Online Advance Organizer Teaching Materials on Students' Science Achievement and Attitude

    Science.gov (United States)

    Korur, Fikret; Toker, Sacip; Eryilmaz, Ali

    2016-01-01

    This two-group quasi-experimental study investigated the effects of the Online Advance Organizer Concept Teaching Material (ONACOM) integrated with inquiry teaching and expository teaching methods. Grade 7 students' posttest performances on the light unit achievement and light unit attitude tests controlled for gender, previous semester science…

  19. Nuclear Energy Advanced Modeling and Simulation (NEAMS) Waste Integrated Performance and Safety Codes (IPSC) : FY10 development and integration.

    Energy Technology Data Exchange (ETDEWEB)

    Criscenti, Louise Jacqueline; Sassani, David Carl; Arguello, Jose Guadalupe, Jr.; Dewers, Thomas A.; Bouchard, Julie F.; Edwards, Harold Carter; Freeze, Geoffrey A.; Wang, Yifeng; Schultz, Peter Andrew

    2011-02-01

    This report describes the progress in fiscal year 2010 in developing the Waste Integrated Performance and Safety Codes (IPSC) in support of the U.S. Department of Energy (DOE) Office of Nuclear Energy Advanced Modeling and Simulation (NEAMS) Campaign. The goal of the Waste IPSC is to develop an integrated suite of computational modeling and simulation capabilities to quantitatively assess the long-term performance of waste forms in the engineered and geologic environments of a radioactive waste storage or disposal system. The Waste IPSC will provide this simulation capability (1) for a range of disposal concepts, waste form types, engineered repository designs, and geologic settings, (2) for a range of time scales and distances, (3) with appropriate consideration of the inherent uncertainties, and (4) in accordance with robust verification, validation, and software quality requirements. Waste IPSC activities in fiscal year 2010 focused on specifying a challenge problem to demonstrate proof of concept, developing a verification and validation plan, and performing an initial gap analyses to identify candidate codes and tools to support the development and integration of the Waste IPSC. The current Waste IPSC strategy is to acquire and integrate the necessary Waste IPSC capabilities wherever feasible, and develop only those capabilities that cannot be acquired or suitably integrated, verified, or validated. This year-end progress report documents the FY10 status of acquisition, development, and integration of thermal-hydrologic-chemical-mechanical (THCM) code capabilities, frameworks, and enabling tools and infrastructure.

  20. Requirements of Integrated Design Teams While Evaluating Advanced Energy Retrofit Design Options in Immersive Virtual Environments

    Directory of Open Access Journals (Sweden)

    Xue Yang

    2015-12-01

    Full Text Available One of the significant ways to save energy use in buildings is to implement advanced energy retrofits in existing buildings. Improving energy performance of buildings through advanced energy retrofitting requires a clear understanding of the cost and energy implications of design alternatives from various engineering disciplines when different retrofit options are considered. The communication of retrofit design alternatives and their energy implications is essential in the decision-making process, as it affects the final retrofit selections and hence the energy efficiency of the retrofitted buildings. The objective of the research presented here was to identify a generic list of information requirements that are needed to be shared and collectively analyzed by integrated design teams during advanced energy retrofit design review meetings held in immersive settings. While identifying such requirements, the authors used an immersive environment based iterative requirements elicitation approach. The technology was used as a means to better identify the information requirements of integrated design teams to be analyzed as a group. This paper provides findings on information requirements of integrated design teams when evaluating retrofit options in immersive virtual environments. The information requirements were identified through interactions with sixteen experts in design and energy modeling domain, and validated with another group of participants consisting of six design experts who were experienced in integrated design processes. Industry practitioners can use the findings in deciding on what information to share with integrated design team members during design review meetings that utilize immersive virtual environments.

  1. Recent Advances in Flexible and Stretchable Bio-Electronic Devices Integrated with Nanomaterials.

    Science.gov (United States)

    Choi, Suji; Lee, Hyunjae; Ghaffari, Roozbeh; Hyeon, Taeghwan; Kim, Dae-Hyeong

    2016-06-01

    Flexible and stretchable electronics and optoelectronics configured in soft, water resistant formats uniquely address seminal challenges in biomedicine. Over the past decade, there has been enormous progress in the materials, designs, and manufacturing processes for flexible/stretchable system subcomponents, including transistors, amplifiers, bio-sensors, actuators, light emitting diodes, photodetector arrays, photovoltaics, energy storage elements, and bare die integrated circuits. Nanomaterials prepared using top-down processing approaches and synthesis-based bottom-up methods have helped resolve the intrinsic mechanical mismatch between rigid/planar devices and soft/curvilinear biological structures, thereby enabling a broad range of non-invasive, minimally invasive, and implantable systems to address challenges in biomedicine. Integration of therapeutic functional nanomaterials with soft bioelectronics demonstrates therapeutics in combination with unconventional diagnostics capabilities. Recent advances in soft materials, devices, and integrated systems are reviewes, with representative examples that highlight the utility of soft bioelectronics for advanced medical diagnostics and therapies.

  2. PERFORMANCE STUDIES OF INTEGRATED FUZZY LOGIC CONTROLLER FOR BRUSHLESS DC MOTOR DRIVES USING ADVANCED SIMULATION MODEL

    Directory of Open Access Journals (Sweden)

    C. Subba Rami Reddy

    2011-07-01

    Full Text Available This paper introduces an Integrated fuzzy logic controller (IFLC for brushless dc (BLDC motor drives using advanced simulation model and presents a comparative study of performances of PID controller and IFLC. The dynamic characteristics of speed and torque are effectively monitored and analyzed using the proposed model. The aim of IFLC is to obtain improved performance in terms of disturbance rejection or parameter variation than obtained using PID controller. The IFLC is constructed by using Fuzzy logic controller (FLC and PID controller. A performance comparison of the controllers is also given based on the integral of the absolute value of the error (IAE, the integral of the squared error (ISE, the integral of the time-weighted absolute error (ITAE and the integral of the time-weighted squared error (ITSE. The results show the effectiveness of the proposed controller.

  3. Advanced, Integrated Control for Building Operations to Achieve 40% Energy Saving

    Energy Technology Data Exchange (ETDEWEB)

    Lu, Yan; Song, Zhen; Loftness, Vivian; Ji, Kun; Zheng, Sam; Lasternas, Bertrand; Marion, Flore; Yuebin, Yu

    2012-10-15

    We developed and demonstrated a software based integrated advanced building control platform called Smart Energy Box (SEB), which can coordinate building subsystem controls, integrate variety of energy optimization algorithms and provide proactive and collaborative energy management and control for building operations using weather and occupancy information. The integrated control system is a low cost solution and also features: Scalable component based architecture allows to build a solution for different building control system configurations with needed components; Open Architecture with a central data repository for data exchange among runtime components; Extendible to accommodate variety of communication protocols. Optimal building control for central loads, distributed loads and onsite energy resource; uses web server as a loosely coupled way to engage both building operators and building occupants in collaboration for energy conservation. Based on the open platform of SEB, we have investigated and evaluated a variety of operation and energy saving control strategies on Carnegie Mellon University Intelligent Work place which is equipped with alternative cooling/heating/ventilation/lighting methods, including radiant mullions, radiant cooling/heating ceiling panels, cool waves, dedicated ventilation unit, motorized window and blinds, and external louvers. Based on the validation results of these control strategies, they were integrated in SEB in a collaborative and dynamic way. This advanced control system was programmed and computer tested with a model of the Intelligent Workplace's northern section (IWn). The advanced control program was then installed in the IWn control system; the performance was measured and compared with that of the state of the art control system to verify the overall energy savings great than 40%. In addition advanced human machine interfaces (HMI's) were developed to communicate both with building

  4. Science based integrated approach to advanced nuclear fuel development - vision, approach, and overview

    Energy Technology Data Exchange (ETDEWEB)

    Unal, Cetin [Los Alamos National Laboratory; Pasamehmetoglu, Kemal [IDAHO NATIONAL LAB; Carmack, Jon [IDAHO NATIONAL LAB

    2010-01-01

    Advancing the performance of Light Water Reactors, Advanced Nuclear Fuel Cycles, and Advanced Rcactors, such as the Next Generation Nuclear Power Plants, requires enhancing our fundamental understanding of fuel and materials behavior under irradiation. The capability to accurately model the nuclear fuel systems is critical. In order to understand specific aspects of the nuclear fuel, fully coupled fuel simulation codes are required to achieve licensing of specific nuclear fuel designs for operation. The backbone of these codes, models, and simulations is a fundamental understanding and predictive capability for simulating the phase and microstructural behavior of the nuclear fuel system materials and matrices. The purpose of this paper is to identify the modeling and simulation approach in order to deliver predictive tools for advanced fuels development. The coordination between experimental nuclear fuel design, development technical experts, and computational fuel modeling and simulation technical experts is a critical aspect of the approach and naturally leads to an integrated, goal-oriented science-based R & D approach and strengthens both the experimental and computational efforts. The Advanced Fuels Campaign (AFC) and Nuclear Energy Advanced Modeling and Simulation (NEAMS) Fuels Integrated Performance and Safety Code (IPSC) are working together to determine experimental data and modeling needs. The primary objective of the NEAMS fuels IPSC project is to deliver a coupled, three-dimensional, predictive computational platform for modeling the fabrication and both normal and abnormal operation of nuclear fuel pins and assemblies, applicable to both existing and future reactor fuel designs. The science based program is pursuing the development of an integrated multi-scale and multi-physics modeling and simulation platform for nuclear fuels. This overview paper discusses the vision, goals and approaches how to develop and implement the new approach.

  5. Advancements in Wind Integration Study Data Modeling: The Wind Integration National Dataset (WIND) Toolkit; Preprint

    Energy Technology Data Exchange (ETDEWEB)

    Draxl, C.; Hodge, B. M.; Orwig, K.; Jones, W.; Searight, K.; Getman, D.; Harrold, S.; McCaa, J.; Cline, J.; Clark, C.

    2013-10-01

    Regional wind integration studies in the United States require detailed wind power output data at many locations to perform simulations of how the power system will operate under high-penetration scenarios. The wind data sets that serve as inputs into the study must realistically reflect the ramping characteristics, spatial and temporal correlations, and capacity factors of the simulated wind plants, as well as be time synchronized with available load profiles. The Wind Integration National Dataset (WIND) Toolkit described in this paper fulfills these requirements. A wind resource dataset, wind power production time series, and simulated forecasts from a numerical weather prediction model run on a nationwide 2-km grid at 5-min resolution will be made publicly available for more than 110,000 onshore and offshore wind power production sites.

  6. Solvent Binding Analysis and Computational Alanine Scanning of the Bovine Chymosin-Bovine κ-Casein Complex Using Molecular Integral Equation Theory.

    Science.gov (United States)

    Palmer, David S; Sørensen, Jesper; Schiøtt, Birgit; Fedorov, Maxim V

    2013-12-10

    We demonstrate that the relative binding thermodynamics of single-point mutants of a model protein-peptide complex (the bovine chymosin-bovine κ-casein complex) can be calculated accurately and efficiently using molecular integral equation theory. The results are shown to be in good overall agreement with those obtained using implicit continuum solvation models. Unlike the implicit continuum models, however, molecular integral equation theory provides useful information about the distribution of solvent density. We find that experimentally observed water-binding sites on the surface of bovine chymosin can be identified quickly and accurately from the density distribution functions computed by molecular integral equation theory. The bovine chymosin-bovine κ-casein complex is of industrial interest because bovine chymosin is widely used to cleave bovine κ-casein and to initiate milk clotting in the manufacturing of processed dairy products. The results are interpreted in light of the recent discovery that camel chymosin is a more efficient clotting agent than bovine chymosin for bovine milk.

  7. Flexible System Integration and Advanced Hierarchical Control Architectures in the Microgrid Research Laboratory of Aalborg University

    DEFF Research Database (Denmark)

    Meng, Lexuan; Hernández, Adriana Carolina Luna; Diaz, Enrique Rodriguez

    2016-01-01

    This paper presents the system integration and hierarchical control implementation in an inverter-based microgrid research laboratory (MGRL) in Aalborg University, Denmark. MGRL aims to provide a flexible experimental platform for comprehensive studies of microgrids. The structure of the laboratory...... system supervision, advanced secondary and tertiary management are realized in a microgrid central controller. The software and hardware schemes are described. Several example case studies are introduced and performed in order to achieve power quality regulation, energy management and flywheel energy...

  8. Integrated Computational Materials Engineering (ICME) for Third Generation Advanced High-Strength Steel Development

    Energy Technology Data Exchange (ETDEWEB)

    Savic, Vesna; Hector, Louis G.; Ezzat, Hesham; Sachdev, Anil K.; Quinn, James; Krupitzer, Ronald; Sun, Xin

    2015-06-01

    This paper presents an overview of a four-year project focused on development of an integrated computational materials engineering (ICME) toolset for third generation advanced high-strength steels (3GAHSS). Following a brief look at ICME as an emerging discipline within the Materials Genome Initiative, technical tasks in the ICME project will be discussed. Specific aims of the individual tasks are multi-scale, microstructure-based material model development using state-of-the-art computational and experimental techniques, forming, toolset assembly, design optimization, integration and technical cost modeling. The integrated approach is initially illustrated using a 980 grade transformation induced plasticity (TRIP) steel, subject to a two-step quenching and partitioning (Q&P) heat treatment, as an example.

  9. Limitation to Advanced Life Support in patients admitted to intensive care unit with integrated palliative care

    Science.gov (United States)

    Mazutti, Sandra Regina Gonzaga; Nascimento, Andréia de Fátima; Fumis, Renata Rego Lins

    2016-01-01

    Objective To estimate the incidence of limitations to Advanced Life Support in critically ill patients admitted to an intensive care unit with integrated palliative care. Methods This retrospective cohort study included patients in the palliative care program of the intensive care unit of Hospital Paulistano over 18 years of age from May 1, 2011, to January 31, 2014. The limitations to Advanced Life Support that were analyzed included do-not-resuscitate orders, mechanical ventilation, dialysis and vasoactive drugs. Central tendency measures were calculated for quantitative variables. The chi-squared test was used to compare the characteristics of patients with or without limits to Advanced Life Support, and the Wilcoxon test was used to compare length of stay after Advanced Life Support. Confidence intervals reflecting p ≤ 0.05 were considered for statistical significance. Results A total of 3,487 patients were admitted to the intensive care unit, of whom 342 were included in the palliative care program. It was observed that after entering the palliative care program, it took a median of 2 (1 - 4) days for death to occur in the intensive care unit and 4 (2 - 11) days for hospital death to occur. Many of the limitations to Advanced Life Support (42.7%) took place on the first day of hospitalization. Cardiopulmonary resuscitation (96.8%) and ventilatory support (73.6%) were the most adopted limitations. Conclusion The contribution of palliative care integrated into the intensive care unit was important for the practice of orthothanasia, i.e., the non-extension of the life of a critically ill patient by artificial means. PMID:27626949

  10. ADVANCED INTEGRATION OF MULTI-SCALE MECHANICS AND WELDING PROCESS SIMULATION IN WELD INTEGRITY ASSESSMENT

    Energy Technology Data Exchange (ETDEWEB)

    Wilkowski, Gery M.; Rudland, David L.; Shim, Do-Jun; Brust, Frederick W.; Babu, Sundarsanam

    2008-06-30

    -driving force by a factor of 2 depending on strain-hardening, pressure level as a % of SMYS, and flaw size. • From years of experience in circumferential fracture analyses and experimentation, there has not been sufficient integration of work performed for other industries into analogous problems facing the oil and gas pipeline markets. Some very basic concepts and problems solved previously in these fields could have circumvented inconsistencies seen in the stress-based and strain-based analysis efforts. For example, in nuclear utility piping work, more detailed elastic-plastic fracture analyses were always validated in their ability to predict loads and displacements (stresses and strains). The eventual implementation of these methodologies will result in acceleration of the industry adoption of higher-strength line-pipe steels.

  11. Integration Science and Technology of Advanced Ceramics for Energy and Environmental Applications

    Science.gov (United States)

    Singh, M.

    2012-01-01

    The discovery of new and innovative materials has been known to culminate in major turning points in human history. The transformative impact and functional manifestation of new materials have been demonstrated in every historical era by their integration into new products, systems, assemblies, and devices. In modern times, the integration of new materials into usable products has a special relevance for the technological development and economic competitiveness of industrial societies. Advanced ceramic technologies dramatically impact the energy and environmental landscape due to potential wide scale applications in all aspects of energy production, storage, distribution, conservation, and efficiency. Examples include gas turbine propulsion systems, fuel cells, thermoelectrics, photovoltaics, distribution and transmission systems based on superconductors, nuclear power generation, and waste disposal. Robust ceramic integration technologies enable hierarchical design and manufacturing of intricate ceramic components starting with geometrically simpler units that are subsequently joined to themselves and/or to metals to create components with progressively higher levels of complexity and functionality. However, for the development of robust and reliable integrated systems with optimum performance under different operating conditions, the detailed understanding of various thermochemical and thermomechanical factors is critical. Different approaches are required for the integration of ceramic-metal and ceramic-ceramic systems across length scales (macro to nano). In this presentation, a few examples of integration of ceramic to metals and ceramic to ceramic systems will be presented. Various challenges and opportunities in design, fabrication, and testing of integrated similar (ceramic-ceramic) and dissimilar (ceramic-metal) material systems will be discussed. Potential opportunities and need for the development of innovative design philosophies, approaches, and

  12. Response to waste electrical and electronic equipments in China: legislation, recycling system, and advanced integrated process.

    Science.gov (United States)

    Zhou, Lei; Xu, Zhenming

    2012-05-01

    Over the past 30 years, China has been suffering from negative environmental impacts from distempered waste electrical and electronic equipments (WEEE) recycling activities. For the purpose of environmental protection and resource reusing, China made a great effort to improve WEEE recycling. This article reviews progresses of three major fields in the development of China's WEEE recycling industry: legal system, formal recycling system, and advanced integrated process. Related laws concerning electronic waste (e-waste) management and renewable resource recycling are analyzed from aspects of improvements and loopholes. The outcomes and challenges for existing formal recycling systems are also discussed. The advantage and deficiency related to advanced integrated recycling processes for typical e-wastes are evaluated respectively. Finally, in order to achieve high disposal rates of WEEE, high-quantify separation of different materials in WEEE and high added value final products produced by separated materials from WEEE, an idea of integrated WEEE recycling system is proposed to point future development of WEEE recycling industry.

  13. Parametric study on the glacier advancement and the integrity of a salt diapir; Parameterstudie zur Gletscherueberfahrung und Integritaet eines Salzdiapirs

    Energy Technology Data Exchange (ETDEWEB)

    Kock, Ingo

    2013-07-15

    In the present work a parameter study on the consequences for geomechanical integrity of glacier advancement above a salt diapir is presented. Different glacier thicknesses as well as speed of advancement and retreat are considered. The parameter study is conducted using a geomechanical numerical model. Results show that relevant criteria (minimum stress criterion and dilatancy criterion) may be violated during advancement of a glacier. The possibility of violating these criteria increases with increasing thickness and increasing speed.

  14. Advanced field-solver techniques for RC extraction of integrated circuits

    CERN Document Server

    Yu, Wenjian

    2014-01-01

    Resistance and capacitance (RC) extraction is an essential step in modeling the interconnection wires and substrate coupling effect in nanometer-technology integrated circuits (IC). The field-solver techniques for RC extraction guarantee the accuracy of modeling, and are becoming increasingly important in meeting the demand for accurate modeling and simulation of VLSI designs. Advanced Field-Solver Techniques for RC Extraction of Integrated Circuits presents a systematic introduction to, and treatment of, the key field-solver methods for RC extraction of VLSI interconnects and substrate coupling in mixed-signal ICs. Various field-solver techniques are explained in detail, with real-world examples to illustrate the advantages and disadvantages of each algorithm. This book will benefit graduate students and researchers in the field of electrical and computer engineering, as well as engineers working in the IC design and design automation industries. Dr. Wenjian Yu is an Associate Professor at the Department of ...

  15. Energy and exergy analyses of an integrated gasification combined cycle power plant with CO2 capture using hot potassium carbonate solvent.

    Science.gov (United States)

    Li, Sheng; Jin, Hongguang; Gao, Lin; Mumford, Kathryn Anne; Smith, Kathryn; Stevens, Geoff

    2014-12-16

    Energy and exergy analyses were studied for an integrated gasification combined cycle (IGCC) power plant with CO2 capture using hot potassium carbonate solvent. The study focused on the combined impact of the CO conversion ratio in the water gas shift (WGS) unit and CO2 recovery rate on component exergy destruction, plant efficiency, and energy penalty for CO2 capture. A theoretical limit for the minimal efficiency penalty for CO2 capture was also provided. It was found that total plant exergy destruction increased almost linearly with CO2 recovery rate and CO conversion ratio at low CO conversion ratios, but the exergy destruction from the WGS unit and the whole plant increased sharply when the CO conversion ratio was higher than 98.5% at the design WGS conditions, leading to a significant decrease in plant efficiency and increase in efficiency penalty for CO2 capture. When carbon capture rate was over around 70%, via a combination of around 100% CO2 recovery rate and lower CO conversion ratios, the efficiency penalty for CO2 capture was reduced. The minimal efficiency penalty for CO2 capture was estimated to be around 5.0 percentage points at design conditions in an IGCC plant with 90% carbon capture. Unlike the traditional aim of 100% CO conversion, it was recommended that extremely high CO conversion ratios should not be considered in order to decrease the energy penalty for CO2 capture and increase plant efficiency.

  16. Study on the Integrated Geophysic Methods and Application of Advanced Geological Detection for Complicated Tunnel

    Science.gov (United States)

    Zhou, L.; Xiao, G.

    2014-12-01

    The engineering geological and hydrological conditions of current tunnels are more and more complicated, as the tunnels are elongated with deeper depth. In constructing these complicated tunnels, geological hazards prone to occur as induced by unfavorable geological bodies, such as fault zones, karst or hydrous structures, etc. The working emphasis and difficulty of the advanced geological exploration for complicated tunnels are mainly focused on the structure and water content of these unfavorable geological bodies. The technical aspects of my paper systematically studied the advanced geological exploration theory and application aspects for complicated tunnels, with discussion on the key technical points and useful conclusions. For the all-aroundness and accuracy of advanced geological exploration results, the objective of my paper is targeted on the comprehensive examination on the structure and hydrous characteristic of the unfavorable geological bodies in complicated tunnels. By the multi-component seismic modeling on a more real model containing the air medium, the wave field response characteristics of unfavorable geological bodies can be analyzed, thus providing theoretical foundation for the observation system layout, signal processing and interpretation of seismic methods. Based on the tomographic imaging theory of seismic and electromagnetic method, 2D integrated seismic and electromagnetic tomographic imaging and visualization software was designed and applied in the advanced drilling hole in the tunnel face, after validation of the forward and inverse modeling results on theoretical models. The transmission wave imaging technology introduced in my paper can be served as a new criterion for detection of unfavorable geological bodies. After careful study on the basic theory, data processing and interpretation, practical applications of TSP and ground penetrating radar (GPR) method, as well as serious examination on their application examples, my paper

  17. Recent Advances in Registration, Integration and Fusion of Remotely Sensed Data: Redundant Representations and Frames

    Science.gov (United States)

    Czaja, Wojciech; Le Moigne-Stewart, Jacqueline

    2014-01-01

    In recent years, sophisticated mathematical techniques have been successfully applied to the field of remote sensing to produce significant advances in applications such as registration, integration and fusion of remotely sensed data. Registration, integration and fusion of multiple source imagery are the most important issues when dealing with Earth Science remote sensing data where information from multiple sensors, exhibiting various resolutions, must be integrated. Issues ranging from different sensor geometries, different spectral responses, differing illumination conditions, different seasons, and various amounts of noise need to be dealt with when designing an image registration, integration or fusion method. This tutorial will first define the problems and challenges associated with these applications and then will review some mathematical techniques that have been successfully utilized to solve them. In particular, we will cover topics on geometric multiscale representations, redundant representations and fusion frames, graph operators, diffusion wavelets, as well as spatial-spectral and operator-based data fusion. All the algorithms will be illustrated using remotely sensed data, with an emphasis on current and operational instruments.

  18. Advancing Exposure Science through Chemical Data Curation and Integration in the Comparative Toxicogenomics Database

    Science.gov (United States)

    Grondin, Cynthia J.; Davis, Allan Peter; Wiegers, Thomas C.; King, Benjamin L.; Wiegers, Jolene A.; Reif, David M.; Hoppin, Jane A.; Mattingly, Carolyn J.

    2016-01-01

    Background: Exposure science studies the interactions and outcomes between environmental stressors and human or ecological receptors. To augment its role in understanding human health and the exposome, we aimed to centralize and integrate exposure science data into the broader biological framework of the Comparative Toxicogenomics Database (CTD), a public resource that promotes understanding of environmental chemicals and their effects on human health. Objectives: We integrated exposure data within the CTD to provide a centralized, freely available resource that facilitates identification of connections between real-world exposures, chemicals, genes/proteins, diseases, biological processes, and molecular pathways. Methods: We developed a manual curation paradigm that captures exposure data from the scientific literature using controlled vocabularies and free text within the context of four primary exposure concepts: stressor, receptor, exposure event, and exposure outcome. Using data from the Agricultural Health Study, we have illustrated the benefits of both centralization and integration of exposure information with CTD core data. Results: We have described our curation process, demonstrated how exposure data can be accessed and analyzed in the CTD, and shown how this integration provides a broad biological context for exposure data to promote mechanistic understanding of environmental influences on human health. Conclusions: Curation and integration of exposure data within the CTD provides researchers with new opportunities to correlate exposures with human health outcomes, to identify underlying potential molecular mechanisms, and to improve understanding about the exposome. Citation: Grondin CJ, Davis AP, Wiegers TC, King BL, Wiegers JA, Reif DM, Hoppin JA, Mattingly CJ. 2016. Advancing exposure science through chemical data curation and integration in the Comparative Toxicogenomics Database. Environ Health Perspect 124:1592–1599; http://dx.doi.org/10

  19. Advancing Environmental Flow Science: Developing Frameworks for Altered Landscapes and Integrating Efforts Across Disciplines

    Science.gov (United States)

    Brewer, Shannon K.; McManamay, Ryan A.; Miller, Andrew D.; Mollenhauer, Robert; Worthington, Thomas A.; Arsuffi, Tom

    2016-08-01

    Environmental flows represent a legal mechanism to balance existing and future water uses and sustain non-use values. Here, we identify current challenges, provide examples where they are important, and suggest research advances that would benefit environmental flow science. Specifically, environmental flow science would benefit by (1) developing approaches to address streamflow needs in highly modified landscapes where historic flows do not provide reasonable comparisons, (2) integrating water quality needs where interactions are apparent with quantity but not necessarily the proximate factor of the ecological degradation, especially as frequency and magnitudes of inflows to bays and estuaries, (3) providing a better understanding of the ecological needs of native species to offset the often unintended consequences of benefiting non-native species or their impact on flows, (4) improving our understanding of the non-use economic value to balance consumptive economic values, and (5) increasing our understanding of the stakeholder socioeconomic spatial distribution of attitudes and perceptions across the landscape. Environmental flow science is still an emerging interdisciplinary field and by integrating socioeconomic disciplines and developing new frameworks to accommodate our altered landscapes, we should help advance environmental flow science and likely increase successful implementation of flow standards.

  20. Advancing Environmental Flow Science: Developing Frameworks for Altered Landscapes and Integrating Efforts Across Disciplines.

    Science.gov (United States)

    Brewer, Shannon K; McManamay, Ryan A; Miller, Andrew D; Mollenhauer, Robert; Worthington, Thomas A; Arsuffi, Tom

    2016-08-01

    Environmental flows represent a legal mechanism to balance existing and future water uses and sustain non-use values. Here, we identify current challenges, provide examples where they are important, and suggest research advances that would benefit environmental flow science. Specifically, environmental flow science would benefit by (1) developing approaches to address streamflow needs in highly modified landscapes where historic flows do not provide reasonable comparisons, (2) integrating water quality needs where interactions are apparent with quantity but not necessarily the proximate factor of the ecological degradation, especially as frequency and magnitudes of inflows to bays and estuaries, (3) providing a better understanding of the ecological needs of native species to offset the often unintended consequences of benefiting non-native species or their impact on flows, (4) improving our understanding of the non-use economic value to balance consumptive economic values, and (5) increasing our understanding of the stakeholder socioeconomic spatial distribution of attitudes and perceptions across the landscape. Environmental flow science is still an emerging interdisciplinary field and by integrating socioeconomic disciplines and developing new frameworks to accommodate our altered landscapes, we should help advance environmental flow science and likely increase successful implementation of flow standards.

  1. Health-related quality of life among patients with advanced cancer: an integrative review

    Directory of Open Access Journals (Sweden)

    Maria Eliane Moreira Freire

    2014-04-01

    Full Text Available This integrative literature review aimed to characterize scientific articles on health-related quality of life – HRQoL – among patients with advanced cancer from national and international literature, and summarize those factors evidenced in the literature that contributed to the improvement or worsening of HRQoL among patients with advanced cancer. The search for materials was conducted in the following databases: CINAHL, EMBASE, PubMed, SciELO and LILACS. Among the 21 articles in the sample, 13 showed an improvement of HRQoL among patients with advanced cancer related to the development of physical, emotional and spiritual interventions. In eight studies, we identified predictive symptoms of low HRQoL, such as pain, fatigue, sleep disorders, depression, nutritional changes, and others. The results showed that clinical manifestations, which many times were inherent in cancer, such as factors that can lower patients’ HRQoL, while physical, psychological and spiritual benefits resulting from therapeutic interventions may promote its improvement.

  2. Solvent Immersion Imprint Lithography

    Energy Technology Data Exchange (ETDEWEB)

    Vasdekis, Andreas E.; Wilkins, Michael J.; Grate, Jay W.; Kelly, Ryan T.; Konopka, Allan; Xantheas, Sotiris S.; Chang, M. T.

    2014-06-21

    The mechanism of polymer disolution was explored for polymer microsystem prototyping, including microfluidics and optofluidics. Polymer films are immersed in a solvent, imprinted and finally brought into contact with a non-modified surface to permanently bond. The underlying polymer-solvent interactions were experimentally and theoretically investigated, and enabled rapid polymer microsystem prototyping. During imprinting, small molecule integration in the molded surfaces was feasible, a principle applied to oxygen sensing. Polystyrene (PS) was employed for microbiological studies at extreme environmental conditions. The thermophile anaerobe Clostridium Thermocellum was grown in PS pore-scale micromodels, revealing a double mean generation lifetime than under ideal culture conditions. Microsystem prototyping through directed polymer dissolution is simple and accessible, while simultaneous patterning, bonding, and surface/volume functionalization are possible in less than one minute.

  3. Geospace Science from Ground-based Magnetometer Arrays: Advances in Sensors, Data Collection, and Data Integration

    Science.gov (United States)

    Mann, Ian; Chi, Peter

    2016-07-01

    , acceleration, and loss of electrons in the radiation belts promise high profile science returns. Integrated, global scale data products also have potential importance and application for real-time monitoring of the space weather threats to electrical power grids from geomagnetically induced currents. Such data exploitation increasingly relies on the collaborations between multiple national magnetometer arrays to generate single data products with common file format and data properties. We review advances in geospace science which can be delivered by networks of ground-based magnetometers - in terms of advances in sensors, data collection, and data integration - including through collaborations within the Ultra-Large Terrestrial International Magnetometer Array (ULTIMA) consortium.

  4. INTEGRATING TECHNOLOGICAL ADVANCEMENTS IN BEHAVIORAL INTERVENTIONS TO PROMOTE HEALTH: UNPRECEDENTED OPORTUNITIES FOR BEHAVIOR ANALYSTS

    Science.gov (United States)

    KURTI, ALLISON N.; DALLERY, JESSE

    2015-01-01

    The use of mobile devices is growing worldwide in both industrialized and developing nations. Alongside the worldwide penetration of web-enabled devices, the leading causes of morbidity and mortality are increasingly modifiable lifestyle factors (e.g., improving one’s diet and exercising more). Behavior analysts have the opportunity to promote health by combining effective behavioral methods with technological advancements. The objectives of this paper are (1) to highlight the public health gains that may be achieved by integrating technology with a behavior analytic approach to developing interventions, and (2) to review some of the currently, under-examined issues related to merging technology and behavior analysis (enhancing sustainability, obtaining frequent measures of behavior, conducting component analyses, evaluating cost-effectiveness, incorporating behavior analysis in the creation of consumer-based applications, and reducing health disparities). Thorough consideration of these issues may inspire the development, implementation, and dissemination of innovative, efficacious interventions that substantially improve global public health. PMID:25774070

  5. BALANCED SCORECARD AS AN ADVANCED MANAGEMENT CONCEPT WITHIN THE INTEGRATED QUALITY MANAGEMENT MODEL

    Directory of Open Access Journals (Sweden)

    Stevan Zivojinovic

    2008-03-01

    Full Text Available The significance of >Integratedquality management< (IQM model, originating form St.Gallen-model, is reflected in the need for synergic application of new and advanced concepts of management theory and practise. Balanced score card (BSC within IQM model becomes a catalyst of business success for a modern organization by focusing on organizational variables-business strategy, organization structure and corporate culture. BSC is the leading system of performance tracking and strategy implementation, consistent with other management concepts and methods for managing process improvement. Through BSC, IQM processes' activities correlate with organization business results. BSC management processes enable integration of all decision-making levels, from institutional via strategic to operative, in the process starting from planing, i.e. formulating and implementation of strategy, to feed back by performance measurement and control.

  6. Effects of the Integrated Online Advance Organizer Teaching Materials on Students' Science Achievement and Attitude

    Science.gov (United States)

    Korur, Fikret; Toker, Sacip; Eryılmaz, Ali

    2016-08-01

    This two-group quasi-experimental study investigated the effects of the Online Advance Organizer Concept Teaching Material (ONACOM) integrated with inquiry teaching and expository teaching methods. Grade 7 students' posttest performances on the light unit achievement and light unit attitude tests controlled for gender, previous semester science grade, and pretest scores were analyzed. No significant treatment effects were found between the inquiry and expository approaches. However, both groups demonstrated significant pretest-posttest gains in achievement and attitude. Independent from the method used, ONACOM was judged effective in both groups as students demonstrated increased achievement and attitude scores. ONACOM has a social and semantic network-aided infrastructure that can be adapted to both methods to increase students' achievement and improve their attitude.

  7. INTEGRATING TECHNOLOGICAL ADVANCEMENTS IN BEHAVIORAL INTERVENTIONS TO PROMOTE HEALTH: UNPRECEDENTED OPORTUNITIES FOR BEHAVIOR ANALYSTS.

    Science.gov (United States)

    Kurti, Allison N; Dallery, Jesse

    2014-09-01

    The use of mobile devices is growing worldwide in both industrialized and developing nations. Alongside the worldwide penetration of web-enabled devices, the leading causes of morbidity and mortality are increasingly modifiable lifestyle factors (e.g., improving one's diet and exercising more). Behavior analysts have the opportunity to promote health by combining effective behavioral methods with technological advancements. The objectives of this paper are (1) to highlight the public health gains that may be achieved by integrating technology with a behavior analytic approach to developing interventions, and (2) to review some of the currently, under-examined issues related to merging technology and behavior analysis (enhancing sustainability, obtaining frequent measures of behavior, conducting component analyses, evaluating cost-effectiveness, incorporating behavior analysis in the creation of consumer-based applications, and reducing health disparities). Thorough consideration of these issues may inspire the development, implementation, and dissemination of innovative, efficacious interventions that substantially improve global public health.

  8. DEMONSTRATION OF AN ADVANCED INTEGRATED CONTROL SYSTEM FOR SIMULTANEOUS EMISSIONS REDUCTION

    Energy Technology Data Exchange (ETDEWEB)

    Suzanne Shea; Randhir Sehgal; Ilga Celmins; Andrew Maxson

    2002-02-01

    The primary objective of the project titled ''Demonstration of an Advanced Integrated Control System for Simultaneous Emissions Reduction'' was to demonstrate at proof-of-concept scale the use of an online software package, the ''Plant Environmental and Cost Optimization System'' (PECOS), to optimize the operation of coal-fired power plants by economically controlling all emissions simultaneously. It combines physical models, neural networks, and fuzzy logic control to provide both optimal least-cost boiler setpoints to the boiler operators in the control room, as well as optimal coal blending recommendations designed to reduce fuel costs and fuel-related derates. The goal of the project was to demonstrate that use of PECOS would enable coal-fired power plants to make more economic use of U.S. coals while reducing emissions.

  9. Scenarios Evaluation Tool for Chlorinated Solvent MNA

    Energy Technology Data Exchange (ETDEWEB)

    Vangelas, Karen; Michael J. Truex; Charles J. Newell; Brian Looney

    2007-02-28

    Over the past three decades, much progress has been made in the remediation of chlorinated solvents from the subsurface. Yet these pervasive contaminants continue to present a significant challenge to the U.S. Department of Energy (DOE), other federal agencies, and other public and private organizations. The physical and chemical properties of chlorinated solvents make it difficult to rapidly reach the low concentrations typically set as regulatory limits. These technical challenges often result in high costs and long remediation time frames. In 2003, the DOE through the Office of Environmental Management funded a science-based technical project that uses the U.S. Environmental Protection Agency's technical protocol (EPA, 1998) and directives (EPA, 1999) on Monitored Natural Attenuation (MNA) as the foundation on which to introduce supporting concepts and new scientific developments that will support remediation of chlorinated solvents based on natural attenuation processes. This project supports the direction in which many site owners want to move to complete the remediation of their site(s), that being to complete the active treatment portion of the remedial effort and transition into MNA. The overarching objective of the effort was to examine environmental remedies that are based on natural processes--remedies such as Monitored Natural Attenuation (MNA) or Enhanced Attenuation (EA). The research program did identify several specific opportunities for advances based on: (1) mass balance as the central framework for attenuation based remedies, (2) scientific advancements and achievements during the past ten years, (3) regulatory and policy development and real-world experience using MNA, and (4) exploration of various ideas for integrating attenuation remedies into a systematic set of ''combined remedies'' for contaminated sites. These opportunities are summarized herein and are addressed in more detail in referenced project documents and

  10. Integration of Advanced Probabilistic Analysis Techniques with Multi-Physics Models

    Energy Technology Data Exchange (ETDEWEB)

    Cetiner, Mustafa Sacit; none,; Flanagan, George F. [ORNL; Poore III, Willis P. [ORNL; Muhlheim, Michael David [ORNL

    2014-07-30

    An integrated simulation platform that couples probabilistic analysis-based tools with model-based simulation tools can provide valuable insights for reactive and proactive responses to plant operating conditions. The objective of this work is to demonstrate the benefits of a partial implementation of the Small Modular Reactor (SMR) Probabilistic Risk Assessment (PRA) Detailed Framework Specification through the coupling of advanced PRA capabilities and accurate multi-physics plant models. Coupling a probabilistic model with a multi-physics model will aid in design, operations, and safety by providing a more accurate understanding of plant behavior. This represents the first attempt at actually integrating these two types of analyses for a control system used for operations, on a faster than real-time basis. This report documents the development of the basic communication capability to exchange data with the probabilistic model using Reliability Workbench (RWB) and the multi-physics model using Dymola. The communication pathways from injecting a fault (i.e., failing a component) to the probabilistic and multi-physics models were successfully completed. This first version was tested with prototypic models represented in both RWB and Modelica. First, a simple event tree/fault tree (ET/FT) model was created to develop the software code to implement the communication capabilities between the dynamic-link library (dll) and RWB. A program, written in C#, successfully communicates faults to the probabilistic model through the dll. A systems model of the Advanced Liquid-Metal Reactor–Power Reactor Inherently Safe Module (ALMR-PRISM) design developed under another DOE project was upgraded using Dymola to include proper interfaces to allow data exchange with the control application (ConApp). A program, written in C+, successfully communicates faults to the multi-physics model. The results of the example simulation were successfully plotted.

  11. CAPE-OPEN Integration for Advanced Process Engineering Co-Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Zitney, S.E.

    2006-11-01

    This paper highlights the use of the CAPE-OPEN (CO) standard interfaces in the Advanced Process Engineering Co-Simulator (APECS) developed at the National Energy Technology Laboratory (NETL). The APECS system uses the CO unit operation, thermodynamic, and reaction interfaces to provide its plug-and-play co-simulation capabilities, including the integration of process simulation with computational fluid dynamics (CFD) simulation. APECS also relies heavily on the use of a CO COM/CORBA bridge for running process/CFD co-simulations on multiple operating systems. For process optimization in the face of multiple and some time conflicting objectives, APECS offers stochastic modeling and multi-objective optimization capabilities developed to comply with the CO software standard. At NETL, system analysts are applying APECS to a wide variety of advanced power generation systems, ranging from small fuel cell systems to commercial-scale power plants including the coal-fired, gasification-based FutureGen power and hydrogen production plant.

  12. Robust Joining and Integration Technologies for Advanced Metallic, Ceramic, and Composite Systems

    Science.gov (United States)

    Singh, M.; Shpargel, Tarah; Morscher, Gregory N.; Halbig, Michael H.; Asthana, Rajiv

    2006-01-01

    Robust integration and assembly technologies are critical for the successful implementation of advanced metallic, ceramic, carbon-carbon, and ceramic matrix composite components in a wide variety of aerospace, space exploration, and ground based systems. Typically, the operating temperature of these components varies from few hundred to few thousand Kelvin with different working times (few minutes to years). The wide ranging system performance requirements necessitate the use of different integration technologies which includes adhesive bonding, low temperature soldering, active metal brazing, diffusion bonding, ARCJoinT, and ultra high temperature joining technologies. In this presentation, a number of joining examples and test results will be provided related to the adhesive bonding and active metal brazing of titanium to C/C composites, diffusion bonding of silicon carbide to silicon carbide using titanium interlayer, titanium and hastelloy brazing to silicon carbide matrix composites, and ARCJoinT joining of SiC ceramics and SiC matrix composites. Various issues in the joining of metal-ceramic systems including thermal expansion mismatch and resulting residual stresses generated during joining will be discussed. In addition, joint design and testing issues for a wide variety of joints will be presented.

  13. A membrane-integrated advanced scheme for treatment of industrial wastewater: dynamic modeling towards scale up.

    Science.gov (United States)

    Kumar, Ramesh; Pal, Parimal

    2013-08-01

    Modeling and simulation was carried out for an advanced membrane-integrated hybrid treatment process that ensures reuse of water with conversion and recovery of ammoniacal nitrogen as value-added struvite fertilizer from coke wastewater. While toxic cyanide was largely removed in a pre-chemical treatment unit using Fenton's reagents under optimized conditions, more than 95% of NH4(+)-N could be recovered as a valuable by-product called struvite through addition of appropriate doses of magnesium and phosphate salts. Water could be turned reusable through a polishing treatment by nanofiltration membranes in a largely fouling free membrane module following a biodegradation step. Mathematical modeling of such an integrated process was done with Haldane-Andrew approach for the associated microbial degradation of phenol by Pseudomonas putida. Residual NH4(+) was degraded by nitrification and denitrification following the modified Monod kinetics. The model could successfully predict the plant performance as reflected in reasonably low relative error (0.03-0.18) and high Willmott d-index (>0.98).

  14. Nuclear Energy Advanced Modeling and Simulation Waste Integrated Performance and Safety Codes (NEAMS Waste IPSC).

    Energy Technology Data Exchange (ETDEWEB)

    Schultz, Peter Andrew

    2011-12-01

    The objective of the U.S. Department of Energy Office of Nuclear Energy Advanced Modeling and Simulation Waste Integrated Performance and Safety Codes (NEAMS Waste IPSC) is to provide an integrated suite of computational modeling and simulation (M&S) capabilities to quantitatively assess the long-term performance of waste forms in the engineered and geologic environments of a radioactive-waste storage facility or disposal repository. Achieving the objective of modeling the performance of a disposal scenario requires describing processes involved in waste form degradation and radionuclide release at the subcontinuum scale, beginning with mechanistic descriptions of chemical reactions and chemical kinetics at the atomic scale, and upscaling into effective, validated constitutive models for input to high-fidelity continuum scale codes for coupled multiphysics simulations of release and transport. Verification and validation (V&V) is required throughout the system to establish evidence-based metrics for the level of confidence in M&S codes and capabilities, including at the subcontiunuum scale and the constitutive models they inform or generate. This Report outlines the nature of the V&V challenge at the subcontinuum scale, an approach to incorporate V&V concepts into subcontinuum scale modeling and simulation (M&S), and a plan to incrementally incorporate effective V&V into subcontinuum scale M&S destined for use in the NEAMS Waste IPSC work flow to meet requirements of quantitative confidence in the constitutive models informed by subcontinuum scale phenomena.

  15. Integration of magnetic bearings in the design of advanced gas turbine engines

    Science.gov (United States)

    Storace, Albert F.; Sood, Devendra K.; Lyons, James P.; Preston, Mark A.

    1994-01-01

    Active magnetic bearings provide revolutionary advantages for gas turbine engine rotor support. These advantages include tremendously improved vibration and stability characteristics, reduced power loss, improved reliability, fault-tolerance, and greatly extended bearing service life. The marriage of these advantages with innovative structural network design and advanced materials utilization will permit major increases in thrust to weight performance and structural efficiency for future gas turbine engines. However, obtaining the maximum payoff requires two key ingredients. The first key ingredient is the use of modern magnetic bearing technologies such as innovative digital control techniques, high-density power electronics, high-density magnetic actuators, fault-tolerant system architecture, and electronic (sensorless) position estimation. This paper describes these technologies. The second key ingredient is to go beyond the simple replacement of rolling element bearings with magnetic bearings by incorporating magnetic bearings as an integral part of the overall engine design. This is analogous to the proper approach to designing with composites, whereby the designer tailors the geometry and load carrying function of the structural system or component for the composite instead of simply substituting composites in a design originally intended for metal material. This paper describes methodologies for the design integration of magnetic bearings in gas turbine engines.

  16. Role of Third Party Logistics Providers with Advanced it to Increase Customer Satisfaction in Supply Chain Integration

    Directory of Open Access Journals (Sweden)

    Zaryab Sheikh

    2012-01-01

    Full Text Available The main area of change in organizational strategy is the extensive use of third party logistics providers who are using advanced information technology tools and integration of supply chain to enhance customer satisfaction. By outsourcing the logistics operations, companies can focus on their core competencies and other important areas of organization which can’t be outsourced. The analysis of this paper is conducted by discussing different concepts of supply chain integration, customer satisfaction, advanced information technology and third party logistics providers, and their impact on customer satisfaction with theoretical framework. An analytical model is also presented.

  17. Large-scale photonic integration for advanced all-optical routing functions

    Science.gov (United States)

    Nicholes, Steven C.

    Advanced InP-based photonic integrated circuits are a critical technology to manage the increasing bandwidth demands of next-generation all-optical networks. Integrating many of the discrete functions required in optical networks into a single device provides a reduction in system footprint and optical losses by eliminating the fiber coupling junctions between components. This translates directly into increased system reliability and cost savings. Although many key network components have been realized via InP-based monolithic integration over the years, truly large-scale photonic ICs have only recently emerged in the marketplace. This lag-time has been mostly due to historically low device yields. In all-optical routing applications, large-scale photonic ICs may be able to address two of the key roadblocks associated with scaling modern electronic routers to higher capacities---namely, power and size. If the functions of dynamic wavelength conversion and routing are moved to the optical layer, we can eliminate the need for power-hungry optical-to-electrical (O/E) and electrical-to-optical (E/O) data conversions at each router node. Additionally, large-scale photonic ICs could reduce the footprint of such a system by combining the similar functions of each port onto a single chip. However, robust design and manufacturing techniques that will enable high-yield production of these chips must be developed. In this work, we demonstrate a monolithic tunable optical router (MOTOR) chip consisting of an array of eight 40-Gbps wavelength converters and a passive arrayed-waveguide grating router that functions as the packet-forwarding switch fabric of an all-optical router. The device represents one of the most complex InP photonic ICs ever reported, with more than 200 integrated functional elements in a single chip. Single-channel 40 Gbps wavelength conversion and channel switching using 231-1 PRBS data showed a power penalty as low as 4.5 dB with less than 2 W drive power

  18. Joint force protection advanced security system (JFPASS) "the future of force protection: integrate and automate"

    Science.gov (United States)

    Lama, Carlos E.; Fagan, Joe E.

    2009-09-01

    The United States Department of Defense (DoD) defines 'force protection' as "preventive measures taken to mitigate hostile actions against DoD personnel (to include family members), resources, facilities, and critical information." Advanced technologies enable significant improvements in automating and distributing situation awareness, optimizing operator time, and improving sustainability, which enhance protection and lower costs. The JFPASS Joint Capability Technology Demonstration (JCTD) demonstrates a force protection environment that combines physical security and Chemical, Biological, Radiological, Nuclear, and Explosive (CBRNE) defense through the application of integrated command and control and data fusion. The JFPASS JCTD provides a layered approach to force protection by integrating traditional sensors used in physical security, such as video cameras, battlefield surveillance radars, unmanned and unattended ground sensors. The optimization of human participation and automation of processes is achieved by employment of unmanned ground vehicles, along with remotely operated lethal and less-than-lethal weapon systems. These capabilities are integrated via a tailorable, user-defined common operational picture display through a data fusion engine operating in the background. The combined systems automate the screening of alarms, manage the information displays, and provide assessment and response measures. The data fusion engine links disparate sensors and systems, and applies tailored logic to focus the assessment of events. It enables timely responses by providing the user with automated and semi-automated decision support tools. The JFPASS JCTD uses standard communication/data exchange protocols, which allow the system to incorporate future sensor technologies or communication networks, while maintaining the ability to communicate with legacy or existing systems.

  19. Advanced treatment of biologically pretreated coal gasification wastewater by a novel integration of catalytic ultrasound oxidation and membrane bioreactor.

    Science.gov (United States)

    Jia, Shengyong; Han, Hongjun; Zhuang, Haifeng; Xu, Peng; Hou, Baolin

    2015-01-01

    Laboratorial scale experiments were conducted to investigate a novel system integrating catalytic ultrasound oxidation (CUO) with membrane bioreactor (CUO-MBR) on advanced treatment of biologically pretreated coal gasification wastewater. Results indicated that CUO with catalyst of FeOx/SBAC (sewage sludge based activated carbon (SBAC) which loaded Fe oxides) represented high efficiencies in eliminating TOC as well as improving the biodegradability. The integrated CUO-MBR system with low energy intensity and high frequency was more effective in eliminating COD, BOD5, TOC and reducing transmembrane pressure than either conventional MBR or ultrasound oxidation integrated MBR. The enhanced hydroxyl radical oxidation, facilitation of substrate diffusion and improvement of cell enzyme secretion were the mechanisms for CUO-MBR performance. Therefore, the integrated CUO-MBR was the promising technology for advanced treatment in engineering applications.

  20. Advanced Communication and Control for Distributed Energy Resource Integration: Phase 2 Scientific Report

    Energy Technology Data Exchange (ETDEWEB)

    BPL Global

    2008-09-30

    The objective of this research project is to demonstrate sensing, communication, information and control technologies to achieve a seamless integration of multivendor distributed energy resource (DER) units at aggregation levels that meet individual user requirements for facility operations (residential, commercial, industrial, manufacturing, etc.) and further serve as resource options for electric and natural gas utilities. The fully demonstrated DER aggregation system with embodiment of communication and control technologies will lead to real-time, interactive, customer-managed service networks to achieve greater customer value. Work on this Advanced Communication and Control Project (ACCP) consists of a two-phase approach for an integrated demonstration of communication and control technologies to achieve a seamless integration of DER units to reach progressive levels of aggregated power output. Phase I involved design and proof-of-design, and Phase II involves real-world demonstration of the Phase I design architecture. The scope of work for Phase II of this ACCP involves demonstrating the Phase I design architecture in large scale real-world settings while integrating with the operations of one or more electricity supplier feeder lines. The communication and control architectures for integrated demonstration shall encompass combinations of software and hardware components, including: sensors, data acquisition and communication systems, remote monitoring systems, metering (interval revenue, real-time), local and wide area networks, Web-based systems, smart controls, energy management/information systems with control and automation of building energy loads, and demand-response management with integration of real-time market pricing. For Phase II, BPL Global shall demonstrate the Phase I design for integrating and controlling the operation of more than 10 DER units, dispersed at various locations in one or more Independent System Operator (ISO) Control Areas, at

  1. ADVANCING THE STUDY OF VIOLENCE AGAINST WOMEN USING MIXED METHODS: INTEGRATING QUALITATIVE METHODS INTO A QUANTITATIVE RESEARCH PROGRAM

    OpenAIRE

    Testa, Maria; Livingston, Jennifer A.; VanZile-Tamsen, Carol

    2011-01-01

    A mixed methods approach, combining quantitative with qualitative data methods and analysis, offers a promising means of advancing the study of violence. Integrating semi-structured interviews and qualitative analysis into a quantitative program of research on women’s sexual victimization has resulted in valuable scientific insight and generation of novel hypotheses for testing. This mixed methods approach is described and recommendations for integrating qualitative data into quantitative res...

  2. Advancing the study of violence against women using mixed methods: integrating qualitative methods into a quantitative research program.

    Science.gov (United States)

    Testa, Maria; Livingston, Jennifer A; VanZile-Tamsen, Carol

    2011-02-01

    A mixed methods approach, combining quantitative with qualitative data methods and analysis, offers a promising means of advancing the study of violence. Integrating semi-structured interviews and qualitative analysis into a quantitative program of research on women's sexual victimization has resulted in valuable scientific insight and generation of novel hypotheses for testing. This mixed methods approach is described and recommendations for integrating qualitative data into quantitative research are provided.

  3. Validation of spectral radiance assignments to integrating sphere radiance standards for the Advanced Baseline Imager

    Science.gov (United States)

    Johnson, B. C.; Maxwell, Stephen; Shirley, Eric; Slack, Kim; Graham, Gary D.

    2014-09-01

    The Advanced Baseline Imager (ABI) is the next-generation imaging sensor for the National Oceanic and Atmospheric Administration's (NOAA's) operational meteorological satellites in geostationary orbit. One pathway for traceability to reference standards of the visible and near-infrared radiometric response for ABI is to a 1.65 m diameter integrating sphere source standard of spectral radiance. This source illuminates the full entrance pupil via the ABI Earth-view port, thus determining the absolute spectral radiance responsivity in the visible and shortwave infrared. The spectral radiance values of the large sphere are assigned by Exelis using a double monochromator and a 15.24 cm diameter integrating sphere source standard that is calibrated by NIST. As part of the ABI program, Exelis was required by NASA to have the spectral radiance values assigned by Exelis to the large sphere be validated by NIST. Here we report the results of that activity, which took place in April, 2013. During the week of April 8, Exelis calibrated the 1.65 m diameter sphere at all 24 levels that correspond to the ABI calibration protocol. During the week of April 15, the NIST validation exercise for five selected levels took place. NIST deployed a portable spectral radiance source, a filter radiometer restricted to the visible and near-infrared, and two spectroradiometers that covered from 350 nm to 2500 nm. The NIST sphere source served as the validation standard. The comparison results, which are reported at the ABI bands, agreed to within the combined uncertainties. We describe the methodology, results, and uncertainty estimates related to this effort.

  4. Advanced receiver autonomous integrity monitoring using triple frequency data with a focus on treatment of biases

    Science.gov (United States)

    El-Mowafy, Ahmed

    2017-04-01

    Most current Advanced Receiver Autonomous Integrity Monitoring (ARAIM) methods are designed to use dual-frequency ionosphere-free observations. These methods assume that receiver bias is absorbed in the common receiver clock offset and bound satellite biases by nominal values. However, most multi-constellation Global Navigation Satellite Systems (GNSS) can offer triple frequency data that can be used for civilian applications in the future, which can improve observation redundancy, solution precision and detection of faults. In this contribution, we explore the use of this type of observations from GPS, Galileo and BeiDou in ARAIM. Nevertheless, the use of triple frequency data introduces receiver differential biases that have to be taken into consideration. To demonstrate the significance of these additional biases we first present a method to quantify them at stations of known coordinates and using available products from the International GNSS service (IGS). To deal with the additional receiver biases, we use a between-satellite single difference (BSSD) observation model that eliminates their effect. A pilot test was performed to evaluate ARAIM availability for Localizer Performance with Vertical guidance down to 200 feet (LPV-200) when using the triple-frequency observations. Real data were collected for one month at stations of known coordinates located in regions of different satellite coverage characteristics. The BSSD triple-frequency model was evaluated to give early indication about its feasibility, where the implementation phase still requires further comprehensive studies. The vertical position error was always found to be bounded by the protection level proven initial validity of the proposed integrity model.

  5. Advancing effects analysis for integrated, large-scale wildfire risk assessment.

    Science.gov (United States)

    Thompson, Matthew P; Calkin, David E; Gilbertson-Day, Julie W; Ager, Alan A

    2011-08-01

    In this article, we describe the design and development of a quantitative, geospatial risk assessment tool intended to facilitate monitoring trends in wildfire risk over time and to provide information useful in prioritizing fuels treatments and mitigation measures. The research effort is designed to develop, from a strategic view, a first approximation of how both fire likelihood and intensity influence risk to social, economic, and ecological values at regional and national scales. Three main components are required to generate wildfire risk outputs: (1) burn probability maps generated from wildfire simulations, (2) spatially identified highly valued resources (HVRs), and (3) response functions that describe the effects of fire (beneficial or detrimental) on the HVR. Analyzing fire effects has to date presented a major challenge to integrated risk assessments, due to a limited understanding of the type and magnitude of changes wrought by wildfire to ecological and other nonmarket values. This work advances wildfire effects analysis, recognizing knowledge uncertainty and appropriately managing it through the use of an expert systems approach. Specifically, this work entailed consultation with 10 fire and fuels program management officials from federal agencies with fire management responsibilities in order to define quantitative resource response relationships as a function of fire intensity. Here, we demonstrate a proof-of-concept application of the wildland fire risk assessment tool, using the state of Oregon as a case study.

  6. Indianapolis I3: the third generation Integrated Advanced Information Management Systems.

    Science.gov (United States)

    McGowan, Julie J; Overhage, J Marc; Barnes, Mike; McDonald, Clement J

    2004-04-01

    In 2001, the Regenstrief Institute for Health Care and the Indiana University School of Medicine (IUSM) began an IAIMS planning effort to create a vision and a tactical plan for the first Integrated Advanced Information Management Systems (IAIMS) implementation to cross a large area and include unaffiliated institutions. A number of elements made this planning effort unique. Among these elements were the existence of a network infrastructure that supported the Indianapolis Network for Patient Care, the existence of a mature medical informatics program at the Regenstrief Institute, and the existence of a wide-area knowledge network fostered by the IUSM libraries. However, the leadership for a strong information technology role in the IUSM that could promote collaboration in support of education and research across the diverse Indianapolis hospital systems had been lacking. By bringing together various groups, each with a commitment to improve health care quality and public health across the Indianapolis metropolitan area, regardless of individual institutional affiliation, the strategic directions for I3-Indianapolis IAIMS Initiative have been defined and the foundations for a third generation IAIMS construct have been laid in Indianapolis, Indiana.

  7. The experiences of pregnant women at an advanced maternal age: an integrative review

    Directory of Open Access Journals (Sweden)

    Juliane Dias Aldrighi

    2016-06-01

    Full Text Available Abstract OBJECTIVE To identify in the literature how the experiences of women age 35 or above are described in terms of pregnancy. METHOD Integrative review based on MEDLINE/PubMed, CINAHL, LILACS, and SciELO databases, with no time period constraint. RESULTS Eighteen studies that dealt with the experiences of pregnant women at an advanced maternal age were selected and analyzed. The studies evidenced four theme categories: the search for information, which pointed to a deficit of information supplied by health care professionals; perceiving the risks, which pointed to women's concerns about their own health and their children's; the ideal moment for motherhood, with different reasons for postponing it; and adjusting to a new routine, showing a concern regarding changes in daily life. CONCLUSION From the results, it was possible to understand that other factors, in addition to those that include risks, are present in the experiences of older pregnant women and point to a need to involve such aspects in nursing care to create comprehensive strategies that are aligned with these women's needs.

  8. Integration of advanced oxidation processes at mild conditions in wet scrubbers for odourous sulphur compounds treatment.

    Science.gov (United States)

    Vega, Esther; Martin, Maria J; Gonzalez-Olmos, Rafael

    2014-08-01

    The effectiveness of different advanced oxidation processes on the treatment of a multicomponent aqueous solution containing ethyl mercaptan, dimethyl sulphide and dimethyl disulphide (0.5 mg L(-1) of each sulphur compound) was investigated with the objective to assess which one is the most suitable treatment to be coupled in wet scrubbers used in odour treatment facilities. UV/H2O2, Fenton, photo-Fenton and ozone treatments were tested at mild conditions and the oxidation efficiency obtained was compared. The oxidation tests were carried out in magnetically stirred cylindrical quartz reactors using the same molar concentration of oxidants (hydrogen peroxide or ozone). The results show that ozone and photo-Fenton are the most efficient treatments, achieving up to 95% of sulphur compounds oxidation and a mineralisation degree around 70% in 10 min. Furthermore, the total costs of the treatments taking into account the capital and operational costs were also estimated for a comparative purpose. The economic analysis revealed that the Fenton treatment is the most economical option to be integrated in a wet scrubber to remove volatile organic sulphur compounds, as long as there are no space constraints to install the required reactor volume. In the case of reactor volume limitation or retrofitting complexities, the ozone and photo-Fenton treatments should be considered as viable alternatives.

  9. Joining and Integration of Advanced Carbon-Carbon Composites to Metallic Systems for Thermal Management Applications

    Science.gov (United States)

    Singh, M.; Asthana, R.

    2008-01-01

    Recent research and development activities in joining and integration of carbon-carbon (C/C) composites to metals such as Ti and Cu-clad-Mo for thermal management applications are presented with focus on advanced brazing techniques. A wide variety of carbon-carbon composites with CVI and resin-derived matrices were joined to Ti and Cu-clad Mo using a number of active braze alloys. The brazed joints revealed good interfacial bonding, preferential precipitation of active elements (e.g., Ti) at the composite/braze interface. Extensive braze penetration of the inter-fiber channels in the CVI C/C composites was observed. The chemical and thermomechanical compatibility between C/C and metals at elevated temperatures is assessed. The role of residual stresses and thermal conduction in brazed C/C joints is discussed. Theoretical predictions of the effective thermal resistance suggest that composite-to-metal brazed joints may be promising for lightweight thermal management applications.

  10. Weekly nanoparticle albumin bound-paclitaxel in combination with cisplatin versus weekly solvent-based paclitaxel plus cisplatin as first-line therapy in Chinese patients with advanced esophageal squamous cell carcinoma

    Directory of Open Access Journals (Sweden)

    Wang HY

    2016-09-01

    Full Text Available Hai-ying Wang, Zhi-hua Yao, Hong Tang, Yan Zhao, Xiao-san Zhang, Shu-na Yao, Shu-jun Yang, Yan-yan Liu Department of Internal Medicine, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, Henan, People’s Republic of China Objective: More effective regimens for advanced esophageal squamous cell carcinoma (ESCC are urgently needed. Therefore, a retrospective study concerning the efficacy and safety of nanoparticle albumin-bound paclitaxel plus cisplatin (nab-TP versus solvent-based paclitaxel plus cisplatin (sb-TP as a first-line therapy was conducted in Chinese patients with advanced ESCC.Methods: From June 2009 to June 2015, 32 patients were treated with nab-paclitaxel (125 mg/m2 on the first and eighth days (30 minutes infusion and cisplatin (75 mg/m2 on the second day every 21 days (nab-TP arm. Also, 43 patients were treated with solvent-based paclitaxel (80 mg/m2 intravenously on the first and eighth days and the same dose of cisplatin (sb-TP arm. The two groups were compared in terms of objective response rate (ORR, disease control rate, progression-free survival (PFS, overall survival (OS, and safety profile. OS and PFS were estimated using Kaplan–Meier methods to determine associations between chemotherapy regimens and survival outcomes.Results: Nab-TP demonstrated a higher ORR (50% vs 30%; P=0.082 and disease control rate (81% vs 65%; P=0.124 than sb-TP. Median OS was similar for nab-TP and sb-TP (12.5 vs 10.7 months; P=0.269. However, nab-TP resulted in a longer median PFS (6.1 months [95% confidence interval: 5.3–6.9] than sb-TP (5.0 months [95% confidence interval: 4.4–5.6] (P=0.029. The most common adverse events included anemia, leukopenia, neutropenia, febrile neutropenia, and thrombocytopenia in both the groups and no statistically significant differences were observed between the groups. With statistically significant differences, significantly less grade ≥3 peripheral neuropathy

  11. 酸性体系中钼的溶剂萃取研究进展%Research advances of molybdenum solvent extraction in acidic system

    Institute of Scientific and Technical Information of China (English)

    李波

    2013-01-01

    The acidic leaching process has been widely applied to the treatment of the materials bearing molyb-denum for the recovery of molybdenum. Moreover, there has been a growing concern on the separation of molybdenum from acidic leaching solutions by solvent extraction. Based on the review of the current research status on acidic, neutral and amine extraction agents that are used in the molybdenum extraction technique from the acid leaching solution, the extraction mechanisms of the various agents and their relative merits are analyzed, and the trend of further study is prospected as well.%目前酸浸工艺已广泛应用于各种含钼物料的处理,而由含钼酸浸溶液中萃取分离钼已愈来愈受到关注。文中在综述酸类萃取剂、中性萃取剂、胺类萃取剂从酸浸液中萃取分离钼工艺研究现状的基础上,对各类萃取剂萃钼机理及优缺点进行了分析,并指出了进一步研究的方向。

  12. Facile synthesis of N-rich carbon quantum dots by spontaneous polymerization and incision of solvents as efficient bioimaging probes and advanced electrocatalysts for oxygen reduction reaction

    Science.gov (United States)

    Lei, Zhouyue; Xu, Shengjie; Wan, Jiaxun; Wu, Peiyi

    2016-01-01

    In this study, uniform nitrogen-doped carbon quantum dots (N-CDs) were synthesized through a one-step solvothermal process of cyclic and nitrogen-rich solvents, such as N-methyl-2-pyrrolidone (NMP) and dimethyl-imidazolidinone (DMEU), under mild conditions. The products exhibited strong light blue fluorescence, good cell permeability and low cytotoxicity. Moreover, after a facile post-thermal treatment, it developed a lotus seedpod surface-like structure of seed-like N-CDs decorating on the surface of carbon layers with a high proportion of quaternary nitrogen moieties that exhibited excellent electrocatalytic activity and long-term durability towards the oxygen reduction reaction (ORR). The peak potential was -160 mV, which was comparable to or even lower than commercial Pt/C catalysts. Therefore, this study provides an alternative facile approach to the synthesis of versatile carbon quantum dots (CDs) with widespread commercial application prospects, not only as bioimaging probes but also as promising electrocatalysts for the metal-free ORR.In this study, uniform nitrogen-doped carbon quantum dots (N-CDs) were synthesized through a one-step solvothermal process of cyclic and nitrogen-rich solvents, such as N-methyl-2-pyrrolidone (NMP) and dimethyl-imidazolidinone (DMEU), under mild conditions. The products exhibited strong light blue fluorescence, good cell permeability and low cytotoxicity. Moreover, after a facile post-thermal treatment, it developed a lotus seedpod surface-like structure of seed-like N-CDs decorating on the surface of carbon layers with a high proportion of quaternary nitrogen moieties that exhibited excellent electrocatalytic activity and long-term durability towards the oxygen reduction reaction (ORR). The peak potential was -160 mV, which was comparable to or even lower than commercial Pt/C catalysts. Therefore, this study provides an alternative facile approach to the synthesis of versatile carbon quantum dots (CDs) with widespread

  13. Advanced Communication and Control for Distributed Energy Resource Integration: Phase 2 Scientific Report

    Energy Technology Data Exchange (ETDEWEB)

    BPL Global

    2008-09-30

    The objective of this research project is to demonstrate sensing, communication, information and control technologies to achieve a seamless integration of multivendor distributed energy resource (DER) units at aggregation levels that meet individual user requirements for facility operations (residential, commercial, industrial, manufacturing, etc.) and further serve as resource options for electric and natural gas utilities. The fully demonstrated DER aggregation system with embodiment of communication and control technologies will lead to real-time, interactive, customer-managed service networks to achieve greater customer value. Work on this Advanced Communication and Control Project (ACCP) consists of a two-phase approach for an integrated demonstration of communication and control technologies to achieve a seamless integration of DER units to reach progressive levels of aggregated power output. Phase I involved design and proof-of-design, and Phase II involves real-world demonstration of the Phase I design architecture. The scope of work for Phase II of this ACCP involves demonstrating the Phase I design architecture in large scale real-world settings while integrating with the operations of one or more electricity supplier feeder lines. The communication and control architectures for integrated demonstration shall encompass combinations of software and hardware components, including: sensors, data acquisition and communication systems, remote monitoring systems, metering (interval revenue, real-time), local and wide area networks, Web-based systems, smart controls, energy management/information systems with control and automation of building energy loads, and demand-response management with integration of real-time market pricing. For Phase II, BPL Global shall demonstrate the Phase I design for integrating and controlling the operation of more than 10 DER units, dispersed at various locations in one or more Independent System Operator (ISO) Control Areas, at

  14. Weekly nanoparticle albumin-bound paclitaxel in combination with cisplatin versus weekly solvent-based paclitaxel plus cisplatin as first-line therapy in Chinese patients with advanced esophageal squamous cell carcinoma

    Science.gov (United States)

    Wang, Hai-ying; Yao, Zhi-hua; Tang, Hong; Zhao, Yan; Zhang, Xiao-san; Yao, Shu-na; Yang, Shu-jun; Liu, Yan-yan

    2016-01-01

    Objective More effective regimens for advanced esophageal squamous cell carcinoma (ESCC) are urgently needed. Therefore, a retrospective study concerning the efficacy and safety of nanoparticle albumin-bound paclitaxel plus cisplatin (nab-TP) versus solvent-based paclitaxel plus cisplatin (sb-TP) as a first-line therapy was conducted in Chinese patients with advanced ESCC. Methods From June 2009 to June 2015, 32 patients were treated with nab-paclitaxel (125 mg/m2) on the first and eighth days (30 minutes infusion) and cisplatin (75 mg/m2) on the second day every 21 days (nab-TP arm). Also, 43 patients were treated with solvent-based paclitaxel (80 mg/m2) intravenously on the first and eighth days and the same dose of cisplatin (sb-TP arm). The two groups were compared in terms of objective response rate (ORR), disease control rate, progression-free survival (PFS), overall survival (OS), and safety profile. OS and PFS were estimated using Kaplan–Meier methods to determine associations between chemotherapy regimens and survival outcomes. Results Nab-TP demonstrated a higher ORR (50% vs 30%; P=0.082) and disease control rate (81% vs 65%; P=0.124) than sb-TP. Median OS was similar for nab-TP and sb-TP (12.5 vs 10.7 months; P=0.269). However, nab-TP resulted in a longer median PFS (6.1 months [95% confidence interval: 5.3–6.9]) than sb-TP (5.0 months [95% confidence interval: 4.4–5.6]) (P=0.029). The most common adverse events included anemia, leukopenia, neutropenia, febrile neutropenia, and thrombocytopenia in both the groups and no statistically significant differences were observed between the groups. With statistically significant differences, significantly less grade ≥3 peripheral neuropathy, arthralgia, and myalgia occurred in the nab-TP arm (all Pline therapy were similar between the two regimens. There were no treatment-related deaths in either group. Conclusion Nab-paclitaxel plus cisplatin is found to be an effective and tolerable option for advanced

  15. Advanced Differential Radar Interferometry (A-DInSAR) as integrative tool for a structural geological analysis

    Science.gov (United States)

    Crippa, B.; Calcagni, L.; Rossi, G.; Sternai, P.

    2009-04-01

    Advanced Differential SAR interferometry (A-DInSAR) is a technique monitoring large-coverage surface deformations using a stack of interferograms generated from several complex SLC SAR images, acquired over the same target area at different times. In this work are described the results of a procedure to calculate terrain motion velocity on highly correlated pixels (E. Biescas, M. Crosetto, M. Agudo, O. Monserrat e B. Crippa: Two Radar Interferometric Approaches to Monitor Slow and Fast Land Deformation, 2007) in two area Gemona - Friuli, Northern Italy, Pollino - Calabria, Southern Italy, and, furthermore, are presented some consideration, based on successful examples of the present analysis. The choice of these pixels whose displacement velocity is calculated depends on the dispersion index value (DA) or using coherence values along the stack interferograms. A-DInSAR technique allows to obtain highly reliable velocity values of the vertical displacement. These values concern the movement of minimum surfaces of about 80m2 at the maximum resolution and the minimum velocity that can be recognized is of the order of mm/y. Because of the high versatility of the technology, because of the large dimensions of the area that can be analyzed (of about 10000Km2) and because of the high precision and reliability of the results obtained, we think it is possible to exploit radar interferometry to obtain some important information about the structural context of the studied area, otherwise very difficult to recognize. Therefore we propose radar interferometry as a valid investigation tool whose results must be considered as an important integration of the data collected in fieldworks.

  16. Virtual Welded-Joint Design Integrating Advanced Materials and Processing Technologies

    Energy Technology Data Exchange (ETDEWEB)

    Yang, Z.; Dong, P.; Liu, S.; Babu, S.; Olson, G.; DebRoy, T.

    2005-04-15

    The primary goal of this project is to increase the fatigue life of a welded-joint by 10 times and to reduce energy use by 25% through product performance and productivity improvements using an integrated modeling approach. The fatigue strength of a welded-joint is currently the bottleneck to design high performance and lightweight welded structures using advanced materials such as high strength steels. In order to achieve high fatigue strength in a welded-joint it is necessary to manage the weld bead shape for lower stress concentration, produce preferable residual stress distribution, and obtain the desired microstructure for improved material toughness and strength. This is a systems challenge that requires the optimization of the welding process, the welding consumable, the base material, as well as the structure design. The concept of virtual welded-joint design has been proposed and established in this project. The goal of virtual welded-joint design is to develop a thorough procedure to predict the relationship of welding process, microstructure, property, residual stress, and the ultimate weld fatigue strength by a systematic modeling approach. The systematic approach combines five sub-models: weld thermal-fluid model, weld microstructure model, weld material property model, weld residual stress model, and weld fatigue model. The systematic approach is thus based on interdisciplinary applied sciences including heat transfer, computational fluid dynamics, materials science, engineering mechanics, and material fracture mechanics. The sub-models are based on existing models with further development. The results from modeling have been validated with critical experiments. The systematic modeling approach has been used to design high fatigue resistant welds considering the combined effects of weld bead geometry, residual stress, microstructure, and material property. In particular, a special welding wire has been developed in this project to introduce

  17. IEDA Thesaurus: A Controlled Vocabulary for IEDA Systems to Advance Integration

    Science.gov (United States)

    Ji, P.; Lehnert, K. A.; Arko, R. A.; Song, L.; Hsu, L.; Carter, M. R.; Ferrini, V. L.; Ash, J.

    2014-12-01

    Integrated Earth Data Applications (IEDA) is a community-based facility that serves to support, sustain, and advance the geosciences by providing data services for observational geoscience data from the Ocean, Earth, and Polar Sciences. Many dedicated systems such as the Petrological Database (PetDB), Marine Geoscience Data System (MGDS), System for Earth Sample Registration (SESAR), Data Coordination Center for the U.S. Antarctic Program (USAP-DCC), etc., under the umbrella of the IEDA framework, were developed to support the preservation, discovery, retrieval, and analysis of a wide range of observational field and analytical data types from diverse communities. However, it is currently difficult to maintain consistency of indexing content within IEDA schema, and perform unified or precise searching of the data in these diverse systems as each system maintains separate vocabularies, hierarchies, authority files, or sub taxonomies. We present here the IEDA Thesaurus, a system, which combines existing separate controlled vocabularies from the different systems under the IEDA schema into a single master controlled vocabulary, also introducing some new top facets for future long-term use. The IEDA thesaurus contains structured terminology for petrology, geochemistry, sedimentology, oceanography, geochronology, and volcanology, and other general metadata fields. 18 top facets (also called 'top categories') are defined, including equipment, geographic gazetteer, geologic ages, geologic units, materials, etc. The terms of the thesaurus are cross validated with others popular geoscience vocabularies such as GeoRef Thesaurus, U.S. Geological Survey Library Classification System, Global Change Master Directory (GCMD), and Semantic Web for Earth and Environmental Terminology (SWEET) ontologies. The thesaurus is organized along with the ANSI/NISO Z39.19-2005 Guidelines for the Construction, Format, and Management of Monolingual Controlled Vocabularies, and is published using

  18. Development of essential system technologies for advanced reactor - Development of natural circulation analysis code for integral reactor

    Energy Technology Data Exchange (ETDEWEB)

    Park, Goon Cherl; Park, Ik Gyu; Kim, Jae Hak; Lee, Sang Min; Kim, Tae Wan [Seoul National University, Seoul (Korea)

    1999-04-01

    The objective of this study is to understand the natural circulation characteristics of integral type reactors and to develope the natural circulation analysis code for integral type reactors. This study is focused on the asymmetric 3-dimensional flow during natural circulation such as 1/4 steam generator section isolation and the inclination of the reactor systems. Natural circulation experiments were done using small-scale facilities of integral reactor SMART (System-Integrated Modular Advanced ReacTor). CFX4 code was used to investigate the flow patterns and thermal mixing phenomena in upper pressure header and downcomer. Differences between normal operation of all steam generators and the 1/4 section isolation conditions were observed and the results were used as the data 1/4 section isolation conditions were observed and the results were used as the data for RETRAN-03/INT code validation. RETRAN-03 code was modified for the development of natural circulation analysis code for integral type reactors, which was development of natural circulation analysis code for integral type reactors, which was named as RETRAN-03/INT. 3-dimensional analysis models for asymmetric flow in integral type reactors were developed using vector momentum equations in RETRAN-03. Analysis results using RETRAN-03/INT were compared with experimental and CFX4 analysis results and showed good agreements. The natural circulation characteristics obtained in this study will provide the important and fundamental design features for the future small and medium integral reactors. (author). 29 refs., 75 figs., 18 tabs.

  19. Green-solvent-processable organic solar cells

    Directory of Open Access Journals (Sweden)

    Shaoqing Zhang

    2016-11-01

    Full Text Available Solution-processable organic photovoltaics (OPV has emerged as a promising clean energy-generating technology due to its potential for low-cost manufacturing with a high power/weight ratio. The state-of-the-art OPV devices are processed by hazardous halogenated solvents. Fabricating high-efficiency OPV devices using greener solvents is a necessary step toward their eventual commercialization. In this review, recent research efforts and advances in green-solvent-processable OPVs are summarized, and two basic strategies including material design and solvent selection of light-harvesting layers are discussed. In particular, the most recent green-solvent-processable OPVs with high efficiencies in excess of 9% are highlighted.

  20. Application of Transformational Leadership Principles in the Development and Integration of Palliative Care Within an Advanced Heart Failure Program.

    Science.gov (United States)

    George, Susan; Leasure, A Renee

    2016-01-01

    Heart failure (HF) is a major health problem in United States, and it has reached epidemic proportions. Heart failure is associated with significant morbidity, mortality, and cost. Although the prognosis of HF is worse than many forms of cancer, many patients, families, and clinicians are unaware of the dire prognosis. As the disease progress to advanced HF, patients are faced with many challenges, such as poor quality of life due to worsening symptoms and frequent hospitalizations. Heart failure management adds significant financial burden to the health care system. Palliative care can be integrated into HF care to improve quality of life and symptom management and to address physical, spiritual, and psychosocial needs of patients and families. Palliative care can be used concurrently with or independent of curative or life-prolonging HF therapies. Transformational leadership principles were used to guide the development of a plan to enhance integration of palliative care within traditional advanced HF care.

  1. Advanced treatment of biologically pretreated coal gasification wastewater by a novel integration of heterogeneous catalytic ozonation and biological process.

    Science.gov (United States)

    Zhuang, Haifeng; Han, Hongjun; Jia, Shengyong; Hou, Baolin; Zhao, Qian

    2014-08-01

    Advanced treatment of biologically pretreated coal gasification wastewater (CGW) was investigated employing heterogeneous catalytic ozonation integrated with anoxic moving bed biofilm reactor (ANMBBR) and biological aerated filter (BAF) process. The results indicated that catalytic ozonation with the prepared catalyst (i.e. MnOx/SBAC, sewage sludge was converted into sludge based activated carbon (SBAC) which loaded manganese oxides) significantly enhanced performance of pollutants removal by generated hydroxyl radicals. The effluent of catalytic ozonation process was more biodegradable and less toxic than that in ozonation alone. Meanwhile, ANMBBR-BAF showed efficient capacity of pollutants removal in treatment of the effluent of catalytic ozonation at a shorter reaction time, allowing the discharge limits to be met. Therefore, the integrated process with efficient, economical and sustainable advantages was suitable for advanced treatment of real biologically pretreated CGW.

  2. Solvents in novolak synthesis

    Science.gov (United States)

    Sobodacha, Chet J.; Lynch, Thomas J.; Durham, Dana L.; Paradis, Valerie R.

    1993-09-01

    Novolac resins may be prepared with or without a solvent present. We have found that solvent power greatly affects the properties of the finished resin and thus gives the resist chemist another variable with which to `fine-tune' resist properties. Using designed experiments, we investigated the effect of solvent power, as measured by Hansen's Solubility Parameters, of a number of solvents and solvent mixtures on the final properties of the novolac resin. We found that the relative molecular weight (RMW) and dissolution rate of a novolac resin can be varied by selection of a solvent or solvent mixture with the appropriate polarity and hydrogen- bonding characteristics. The solvent polarity and hydrogen-bonding characteristics may affect the stability of the cresol/formaldehyde transition state, thus causing the observed changes in RMW and dissolution rate.

  3. Moving integrated weed management from low level to a truly integrated and highly specific weed management system using advanced technologies

    NARCIS (Netherlands)

    Young, S.L.; Pitla, S.K.; Evert, Van F.K.; Schueller, J.K.; Pierce, F.J.; Liebman, Matt

    2017-01-01

    Integrated weed management (IWM) is one of the most commonly referred to approaches for sustainable and effective weed control in agriculture, yet it is not widely practiced, likely because current IWM systems fail to meet performance expectations of growers. The effectiveness and value of IWM syste

  4. Advanced treatment of biologically pretreated coal gasification wastewater by a novel integration of heterogeneous Fenton oxidation and biological process.

    Science.gov (United States)

    Xu, Peng; Han, Hongjun; Zhuang, Haifeng; Hou, Baolin; Jia, Shengyong; Xu, Chunyan; Wang, Dexin

    2015-04-01

    Laboratorial scale experiments were conducted in order to investigate a novel system integrating heterogeneous Fenton oxidation (HFO) with anoxic moving bed biofilm reactor (ANMBBR) and biological aerated filter (BAF) process on advanced treatment of biologically pretreated coal gasification wastewater (CGW). The results indicated that HFO with the prepared catalyst (FeOx/SBAC, sewage sludge based activated carbon (SBAC) which loaded Fe oxides) played a key role in eliminating COD and COLOR as well as in improving the biodegradability of raw wastewater. The surface reaction and hydroxyl radicals (OH) oxidation were the mechanisms for FeOx/SBAC catalytic reaction. Compared with ANMBBR-BAF process, the integrated system was more effective in abating COD, BOD5, total phenols (TPs), total nitrogen (TN) and COLOR and could shorten the retention time. Therefore, the integrated system was a promising technology for engineering applications.

  5. Solvent abuse: a review.

    Science.gov (United States)

    Barnes, G E

    1979-01-01

    The literature on solvent abuse is reviewed. Methods of use, symptoms of use, and effects of long-term solvent abuse are discussed. Several surveys on solvent use are summarized. The highest prevalence of solvent abuse seems to occur in native peoples undergoing periods of cultural change. Environmental conditions which are postulated as leading to psychological vulnerability and solvent abuse include: low social assets, parental drug use, peer and sibling influence, and acculturative stress. Solvent abuse seems to provide a pharmacological way out of a stressful environment for people who feel helpless to improve their situation in other ways. Methods of intervention that have been proposed for dealing with solvent abuse are discussed. Methods of intervention thus far employed generally have not been evaluated in any systematic fashion. Suggestions for future research are provided.

  6. FAA/NASA International Symposium on Advanced Structural Integrity Methods for Airframe Durability and Damage Tolerance

    Science.gov (United States)

    Harris, Charles E. (Editor)

    1994-01-01

    International technical experts in durability and damage tolerance of metallic airframe structures were assembled to present and discuss recent research findings and the development of advanced design and analysis methods, structural concepts, and advanced materials. The symposium focused on the dissemination of new knowledge and the peer-review of progress on the development of advanced methodologies. Papers were presented on: structural concepts for enhanced durability, damage tolerance, and maintainability; new metallic alloys and processing technology; fatigue crack initiation and small crack effects; fatigue crack growth models; fracture mechanics failure, criteria for ductile materials; structural mechanics methodology for residual strength and life prediction; development of flight load spectra for design and testing; and advanced approaches to resist corrosion and environmentally assisted fatigue.

  7. Integrated Advanced Monopropellant CMC Thruster / Thermal Stand-Off Assembly Project

    Data.gov (United States)

    National Aeronautics and Space Administration — High performance non-toxic monopropellants offer significant benefits relative to the current state-of-the-art. The benefits of these advanced monopropellants (AMP)...

  8. Integrating Prognostics in Automated Contingency Management Strategies for Advanced Aircraft Controls Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Impact Technologies, in collaboration with Georgia Institute of Technology, proposes to develop and demonstrate innovative technologies to integrate prognostics into...

  9. Is health systems integration being advanced through Local Health District planning?

    Science.gov (United States)

    Saunders, Carla; Carter, David J

    2016-04-21

    Objective Delivering genuine integrated health care is one of three strategic directions in the New South Wales (NSW) Government State Health Plan: Towards 2021. This study investigated the current key health service plan of each NSW Local Health District (LHD) to evaluate the extent and nature of health systems integration strategies that are currently planned.Methods A scoping review was conducted to identify common key principles and practices for successful health systems integration to enable the development of an appraisal tool to content assess LHD strategic health service plans.Results The strategies that are planned for health systems integration across LHDs focus most often on improvements in coordination, health care access and care delivery for complex at-risk patients across the care continuum by both state- and commonwealth-funded systems, providers and agencies. The most common reasons given for integrated activities were to reduce avoidable hospitalisation, avoid inappropriate emergency department attendance and improve patient care.Conclusions Despite the importance of health systems integration and finding that all NSW LHDs have made some commitment towards integration in their current strategic health plans, this analysis suggests that health systems integration is in relatively early development across NSW.What is known about the topic? Effective approaches to managing complex chronic diseases have been found to involve health systems integration, which necessitates sound communication and connection between healthcare providers across community and hospital settings. Planning based on current health systems integration knowledge to ensure the efficient use of scarce resources is a responsibility of all health systems.What does this paper add? Appropriate planning and implementation of health systems integration is becoming an increasingly important expectation and requirement of effective health systems. The present study is the first of its

  10. PRELIMINARY TECHNICAL AND ECONOMIC FEASIBILITY STUDY ON THE INTEGRATION OF A PROCESS UTILIZING LOW-ENERGY SOLVENTS FOR CARBON DIOXIDE CAPTURE ENABLED BY A COMBINATION OF ENZYMES AND ULTRASONICS WITH A SUBCRITICAL PC POWER PLANT

    Energy Technology Data Exchange (ETDEWEB)

    Swaminathan, Saravanan; Kuczynska, Agnieszka; Hume, Scott; Mulgundmath, Vinay; Freeman, Charles; Bearden, Mark; Remias, Joe; Ambedkar, Balraj; Salmon, Sonja; House, Alan

    2012-11-01

    The results of the preliminary techno-economic assessment for integrating a process utilizing low-energy solvents for carbon dioxide (CO2) capture enabled by a combination of enzymes and ultrasonics with a subcritical pulverized coal (PC) power plant are presented. Four cases utilizing the enzyme-activated solvent are compared using different methodologies of regeneration against the DOE/NETL reference MEA case. The results are shown comparing the energy demand for post-combustion CO2 capture and the net higher heating value (HHV) efficiency of the power plant integrated with the post-combustion capture (PCC) plant. A levelized cost of electricity (LCOE) assessment was performed showing the costs of the options presented in the study. The key factors contributing to the reduction of LCOE were identified as enzyme make-up rate and the capability of the ultrasonic regeneration process. The net efficiency of the integrated PC power plant with CO2 capture changes from 24.9% with the reference Case 10 plant to between 24.34% and 29.97% for the vacuum regeneration options considered, and to between 26.63% and 31.41% for the ultrasonic regeneration options. The evaluation also shows the effect of the critical parameters on the LCOE, with the main variable being the initial estimation of enzyme dosing rate. The LCOE ($/MWh) values range from 112.92 to 125.23 for the vacuum regeneration options and from 108.9 to 117.50 for the ultrasonic regeneration cases considered in comparison to 119.6 for the reference Case 10. A sensitivity analysis of the effect of critical parameters on the LCOE was also performed. The results from the preliminary techno-economic assessment show that the proposed technology can be investigated further with a view to being a viable alternative to conventional CO2 scrubbing technologies.

  11. AGAPE-ET: An Advanced HRA Method Integrating Errors of Omission (EOO) and Errors of Commission (EOC)

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Jae Whan; Jung, Won Dea; Park, Jin Kyun

    2007-01-15

    The objective of this project is to develop an advanced HRA framework or methodology that integrates the standard HRA method and the EOC analysis method in a single framework under emergency situations. Through the study, an advanced, integrated HRA method, which is named AGAPE-ET standing for Advanced Guidelines for Analysing Prospective human Events in Emergency Tasks, that can analyse human erroneous events involving EOCs and EOOs in accident scenarios of nuclear power plants. According to the basic structure of the emergency operating procedures (EOP) of the nuclear power plants, the AGAPE-ET method is composed of largely two parts, i.e. (1) group 1: analysis of the human erroneous events that might be caused from an initial diagnosis failure, and (2) group 2: analysis of the human erroneous events that could occur during event responses after a success in an initial diagnosis. The subjects of the group 1 can be single initiating events and the multiple events that could occur prior to the event diagnosis by the operators. For the group 2, accident scenarios are classified into 3 cases according to the situational characteristics of the human involvement, and analysis methods are suggested for each of the cases. In addition, the applicability and effectiveness of the AGAPE-ET framework has been verified through a pilot study for a small-loss of coolant accident (SLOCA). According to the application to the SLOCA event, the risk impact of a diagnosis failure is seen to be relatively high.

  12. Integrative advances for OCT-guided ophthalmic surgery and intraoperative OCT: microscope integration, surgical instrumentation, and heads-up display surgeon feedback.

    Directory of Open Access Journals (Sweden)

    Justis P Ehlers

    Full Text Available PURPOSE: To demonstrate key integrative advances in microscope-integrated intraoperative optical coherence tomography (iOCT technology that will facilitate adoption and utilization during ophthalmic surgery. METHODS: We developed a second-generation prototype microscope-integrated iOCT system that interfaces directly with a standard ophthalmic surgical microscope. Novel features for improved design and functionality included improved profile and ergonomics, as well as a tunable lens system for optimized image quality and heads-up display (HUD system for surgeon feedback. Novel material testing was performed for potential suitability for OCT-compatible instrumentation based on light scattering and transmission characteristics. Prototype surgical instruments were developed based on material testing and tested using the microscope-integrated iOCT system. Several surgical maneuvers were performed and imaged, and surgical motion visualization was evaluated with a unique scanning and image processing protocol. RESULTS: High-resolution images were successfully obtained with the microscope-integrated iOCT system with HUD feedback. Six semi-transparent materials were characterized to determine their attenuation coefficients and scatter density with an 830 nm OCT light source. Based on these optical properties, polycarbonate was selected as a material substrate for prototype instrument construction. A surgical pick, retinal forceps, and corneal needle were constructed with semi-transparent materials. Excellent visualization of both the underlying tissues and surgical instrument were achieved on OCT cross-section. Using model eyes, various surgical maneuvers were visualized, including membrane peeling, vessel manipulation, cannulation of the subretinal space, subretinal intraocular foreign body removal, and corneal penetration. CONCLUSIONS: Significant iterative improvements in integrative technology related to iOCT and ophthalmic surgery are demonstrated.

  13. DEVELOPMENT OF AN ADVANCED APPROACH FOR NEXT-GENERATION INTEGRATED RESERVOIR CHARACTERIZATION

    Energy Technology Data Exchange (ETDEWEB)

    Scott R. Reeves

    2005-04-01

    Accurate, high-resolution, three-dimensional (3D) reservoir characterization can provide substantial benefits for effective oilfield management. By doing so, the predictive reliability of reservoir flow models, which are routinely used as the basis for investment decisions involving hundreds of millions of dollars and designed to recover millions of barrels of oil, can be significantly improved. Even a small improvement in incremental recovery for high-value assets can result in important contributions to bottom-line profitability. Today's standard practice for developing a 3D reservoir description is to use seismic inversion techniques. These techniques make use of geostatistics and other stochastic methods to solve the inverse problem, i.e., to iteratively construct a likely geologic model and then upscale and compare its acoustic response to that actually observed in the field. This method has several inherent flaws, such as: (1) The resulting models are highly non-unique; multiple equiprobable realizations are produced, meaning (2) The results define a distribution of possible outcomes; the best they can do is quantify the uncertainty inherent in the modeling process, and (3) Each realization must be run through a flow simulator and history matched to assess it's appropriateness, and therefore (4) The method is labor intensive and requires significant time to complete a field study; thus it is applied to only a small percentage of oil and gas producing assets. A new approach to achieve this objective was first examined in a Department of Energy (DOE) study performed by Advanced Resources International (ARI) in 2000/2001. The goal of that study was to evaluate whether robust relationships between data at vastly different scales of measurement could be established using virtual intelligence (VI) methods. The proposed workflow required that three specific relationships be established through use of artificial neural networks (ANN's): core

  14. The Plant-Window System: A framework for an integrated computing environment at advanced nuclear power plants

    Energy Technology Data Exchange (ETDEWEB)

    Wood, R.T.; Mullens, J.A. [Oak Ridge National Lab., TN (United States); Naser, J.A. [Electric Power Research Inst., Palo Alto, CA (United States)

    1997-10-01

    Power plant data, and the information that can be derived from it, provide the link to the plant through which the operations, maintenance and engineering staff understand and manage plant performance. The extensive use of computer technology in advanced reactor designs provides the opportunity to greatly expand the capability to obtain, analyze, and present data about the plant to station personnel. However, to support highly efficient and increasingly safe operation of nuclear power plants, it is necessary to transform the vast quantity of available data into clear, concise, and coherent information that can be readily accessed and used throughout the plant. This need can be met by an integrated computer workstation environment that provides the necessary information and software applications, in a manner that can be easily understood and sued, to the proper users throughout the plan. As part of a Cooperative Research and Development Agreement with the Electric Power Research Institute, the Oak Ridge National laboratory has developed functional requirements for a Plant-Wide Integrated Environment Distributed On Workstations (Plant-Window) System. The Plant-Window System (PWS) can serve the needs of operations, engineering, and maintenance personnel at nuclear power stations by providing integrated data and software applications within a common computing environment. The PWS requirements identify functional capabilities and provide guidelines for standardized hardware, software, and display interfaces so as to define a flexible computing environment for both current generation nuclear power plants and advanced reactor designs.

  15. PRELIMINARY ENVIRONMENTAL, HEALTH AND SAFETY RISK ASSESSMENT ON THE INTEGRATION OF A PROCESS UTILIZING LOW-ENERGY SOLVENTS FOR CARBON DIOXIDE CAPTURE ENABLED BY A COMBINATION OF ENZYMES AND VACUUM REGENERATION WITH A SUBCRITICAL PC POWER PLANT

    Energy Technology Data Exchange (ETDEWEB)

    Fitzgerald, David; Vidal, Rafael; Russell, Tania; Babcock, Doosan; Freeman, Charles; Bearden, Mark; Whyatt, Greg; Liu, Kun; Frimpong, Reynolds; Lu, Kunlei; Salmon, Sonja; House, Alan; Yarborough, Erin

    2014-12-31

    The results of the preliminary environmental, health and safety (EH&S) risk assessment for an enzyme-activated potassium carbonate (K2CO3) solution post-combustion CO2 capture (PCC) plant, integrated with a subcritical pulverized coal (PC) power plant, are presented. The expected emissions during normal steady-state operation have been estimated utilizing models of the PCC plant developed in AspenTech’s AspenPlus® software, bench scale test results from the University of Kentucky, and industrial experience of emission results from a slipstream PCC plant utilizing amine based solvents. A review of all potential emission species and their sources was undertaken that identified two credible emission sources, the absorber off-gas that is vented to atmosphere via a stack and the waste removed from the PCC plant in the centrifuge used to reclaim enzyme and solvent. The conditions and compositions of the emissions were calculated and the potential EH&S effects were considered as well as legislative compliance requirements. Potential mitigation methods for emissions during normal operation have been proposed and solutions to mitigate uncontrolled releases of species have been considered. The potential emissions were found to pose no significant EH&S concerns and were compliant with the Federal legislation reviewed. The limitations in predicting full scale plant performance from bench scale tests have been noted and further work on a larger scale test unit is recommended to reduce the level of uncertainty.

  16. Therapeutic Evaluation on Advanced Pancreatic Cancer Treated by Integrative Chinese and Western Medicine Clinical Analysis of 56 Cases

    Institute of Scientific and Technical Information of China (English)

    刘鲁明; 吴良村; 林胜友; 杨维鸿; 郭勇; 徐颖扉; 舒琦瑾

    2003-01-01

    Objective: In comparison with chemotherapy, to evaluate therapeutic effcts on advanced pancreatic cancer treated by integrative Chinese and western medicine (ICWM) therapies. Methods: Based on the retrospective study of 56 patients with advanced pancreatic cancer,life table was applied to the analysis of patients' survival rate and χ2 test to the comparison of therapeutic response between ICWM and chemotherapy groups. Results: The results showed that 1-year survival rate in the ICWM group was 55.37%±3.24%; 2-year survival rate 34.61%±16.31%; 3-year survival rate 25.96%±24.64%; 5-year survival rate 25.96%±24.64%; and median survival period 16.3 months. However 1-year survival rate in the chemotherapy group was 21.95%±27.54%; 2-year survival rate 7.31%±27.54%; 3-year survival rate 0%; and median survival period 7.5 months. The therapeutic effects between two groups were significantly different (P=0.004). Further analysis suggested that the reduction of cancer mass in the ICWM group was more than that in chemotherapy group (P=0.049) and the improvement of advanced pancreatic cancer related-symptoms better than that of chemotherapy group (P=0.002). Conclusion: The ICWM comprehensive therapy is of important value in the treatment of advanced pancreatic cancer.

  17. Therapeutic Evaluation on Advanced Pancreatic Cancer Treated by Integrative Chinese and Western Medicine—Clinical Analysis of 56 Cases

    Institute of Scientific and Technical Information of China (English)

    LIULu-ming; WULiang-cun; 等

    2003-01-01

    Objective:In comparison with chemotherapy,to evaluate therapeutic effects on advanced pancreatic cancer treated by integrative Chinese and western medicine(ICWM) therapies.Methods:Based on the retrospective study of 56 patients with advanced pancreatic cancer,life table was applied to the anal-ysis of patients' survival rate and X2 test to the comparison of therapeutic response between ICWM and chemotherapy groups.Results:The results showed that 1-year survival rate 25.96%±24.64%; 5-year 37%±3.24%;2-year survival rate 34.61%±16.31%;3-year survival rate 25.96%±24.64%;5-year survival rate 25.96%±24.64%; and median survival period 16.3 months.However 1-year survival rate in the chemotherapy group was 21.95%±27.54%;2-year survival rate 7.31%±27.54%;3-year survival rate 0%; and median survival period 7.5months.The therapeutic effects between two groups were signifi-cantly different(P=0.004).Further analysis suggested that the reduction of cancer mass in the ICWM group was more than that in chemotherapy group(P=0.049) and the improvement of advanced pancreatic cancer related-symptoms better than that of chemotherapy group(P=0.002).Conclusion:The ICWM comprehensive therapy is of important value in the treatment of advanced pancreatic cancer.

  18. Integrated Advanced Microwave Sounding Unit-A (AMSU-A). Performance Verification Report: Antenna Drive Subsystem METSAT AMSU-A2 (PN:1331200-2, SN:108)

    Science.gov (United States)

    Haapala, C.

    1999-01-01

    This is the Performance Verification Report, Antenna Drive Subassembly, Antenna Drive Subsystem, METSAT AMSU-A2 (P/N 1331200-2, SN: 108), for the Integrated Advanced Microwave Sounding Unit-A (AMSU-A).

  19. Developing and Integrating Advanced Movement Features Improves Automated Classification of Ciliate Species.

    Directory of Open Access Journals (Sweden)

    Ali Soleymani

    Full Text Available Recent advances in tracking technologies such as GPS or video tracking systems describe the movement paths of individuals in unprecedented details and are increasingly used in different fields, including ecology. However, extracting information from raw movement data requires advanced analysis techniques, for instance to infer behaviors expressed during a certain period of the recorded trajectory, or gender or species identity in case data is obtained from remote tracking. In this paper, we address how different movement features affect the ability to automatically classify the species identity, using a dataset of unicellular microbes (i.e., ciliates. Previously, morphological attributes and simple movement metrics, such as speed, were used for classifying ciliate species. Here, we demonstrate that adding advanced movement features, in particular such based on discrete wavelet transform, to morphological features can improve classification. These results may have practical applications in automated monitoring of waste water facilities as well as environmental monitoring of aquatic systems.

  20. [Neurotoxicity of organic solvents--recent findings].

    Science.gov (United States)

    Matsuoka, Masato

    2007-06-01

    In this review, the recent findings of central nervous system (CNS) or peripheral nervous system (PNS) dysfunction induced by occupational exposure to organic solvents are described. While acute, high-level exposure to almost all organic solvents causes the general, nonspecific depression of CNS, it is still not clear whether chronic, low-level occupational exposure causes the chronic neurological dysfunction which has been called "organic solvent syndrome", "painters syndrome", "psycho-organic syndrome" or "chronic solvent encephalopathy". At least at lower than occupational exposure limits, chronic and low-level organic solvent exposure does not appear to cause the "sy mptomatic" neurological dysfunction. The chronic, moderate- to high-level exposure to a few organic solvents (such as carbon disulfide, n-hexane and methyl n-butyl ketone) affects CNS or PNS specifically. The substitutes for chlorofluorocarbons, 2-bromopropane and 1-bromopropane were shown to have the peripheral nerve toxicity in the experimental animals. Shortly after these observations, human cases of 1-bromopropane intoxication with the dysfunction of CNS and PNS were reported in the United States. Neurological abnormalities in workers of a 1-bromopropane factory in China were also reported. Thus, the possible neurotoxicity of newly introduced substitutes for ozone-depleting solvents into the workplace must be considered. Enough evidences indicate that some common solvents (such as toluene and styrene) induce sensorineural hearing loss and acquired color vision disturbances in workers. In some studies using magnetic resonance imaging (MRI), cerebral atrophy, patchy periventricular hyperintensities and hypointensities in the basal ganglia were found in solvent-exposed workers as have been shown in toluene abusers (toluene leukoencephalopathy). Further studies using the neurobehavioral test batteries, neurophysiological measurements and advanced neuroimaging techniques are required to detect the

  1. Advanced Energy Harvesting from Macroalgae—Innovative Integration of Drying, Gasification and Combined Cycle

    Directory of Open Access Journals (Sweden)

    Muhammad Aziz

    2014-12-01

    Full Text Available State-of-the-art integrated macroalgae utilization processes, consisting of drying, gasification, and combined cycle, are proposed and their performance with respect to energy efficiency are evaluated. To achieve high exergy efficiency, the integration is performed through two main principles: exergy recovery and process integration. Initially, the energy involved in one process is recirculated intensively through exergy elevation and effective heat coupling. Furthermore, the unrecoverable energy from one process will be utilized in the other processes through process integration. As the result, the total exergy destruction from the whole integrated processes can be minimized significantly leading to significant improvement in energy efficiency. The first analysis relates to the performance of integrated drying process, especially the influence of target moisture content to energy consumption. Furthermore, the influences of gasification fluidization velocity to the total generated power and power generation efficiency are also calculated. As the results of study, the proposed integrated-processes proved a very high energy efficiency. A positive energy harvesting with the total power generation efficiency of about 40% could be achieved.

  2. The Attending Nurse Caring Model: integrating theory, evidence and advanced caring-healing therapeutics for transforming professional practice.

    Science.gov (United States)

    Watson, Jean; Foster, Roxie

    2003-05-01

    This paper presents a proposed model: The Attending Nursing Caring Model (ANCM) as an exemplar for advancing and transforming nursing practice within a reflective, theoretical and evidence-based context. Watson's theory of human caring is used as a guide for integrating theory, evidence and advanced therapeutics in the area of children's pain. The ANCM is offered as a programme for renewing the profession and its professional practices of caring-healing arts and science, during an era of decline, shortages, and crises in care, safety, and hospital and health reform. The ANCM elevates contemporary nursing's caring values, relationships, therapeutics and responsibilities to a higher/deeper order of caring science and professionalism, intersecting with other professions, while sustaining the finest of its heritage and traditions of healing.

  3. Development and Integration of a HEMS with an Advanced Smart Metering Infrastructure

    DEFF Research Database (Denmark)

    Diaz, Enrique Rodriguez; Palacios-Garcia, Emilio; Savaghebi, Mehdi

    2016-01-01

    Advanced metering infrastructures (AMI) are required for the future smart grid operation by providing useful information about users’ behavior as well as grid performance such as the consumption and power quality. This paper is focused on the development of a LabVIEW application for user-interfac......Advanced metering infrastructures (AMI) are required for the future smart grid operation by providing useful information about users’ behavior as well as grid performance such as the consumption and power quality. This paper is focused on the development of a LabVIEW application for user...

  4. Integrating Prognostics in Automated Contingency Management Strategies for Advanced Aircraft Controls Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Automated Contingency Management (ACM) is an emerging and game-changing area of engineering and scientific research that integrates prognostics and health management...

  5. Advanced Data Mining and Deployment for Integrated Vehicle Health Management and the Space Vehicle Lifecycle Project

    Data.gov (United States)

    National Aeronautics and Space Administration — In a successful Phase 1 project for NASA SBIR topic A1.05, "Data Mining for Integrated Vehicle Health Management," Michigan Aerospace Corporation (MAC) demonstrated...

  6. The role of business information management in advanced integrated environmental management systems

    DEFF Research Database (Denmark)

    Ulhøi, John Parm

    2000-01-01

    investments in the individual company. Secondly, based on the above, to calculate and assess some typical quantifiable savings, e.g. on energy and raw materials, over a period of four years (after the implementation of the integrated environmental management system). In line with other similar investigations......, the study shows that the implementation of systematic and integrated environmental management systems results in significant savings. This supports the general, albeit rarely tested, hypothesis that it pays to be an environmentally responsible enterprise....

  7. Integrated hot fuel gas cleaning for advanced gasification combined cycle process

    Energy Technology Data Exchange (ETDEWEB)

    Nieminen, M.; Kangasmaa, K.; Laatikainen, J.; Staahlberg, P.; Kurkela, E. [VTT Energy, Espoo (Finland). Gasification and Advanced Combustion

    1996-12-01

    The fate of halogens in pressurised fluidized-bed gasification and hot gas filtration is determined. Potential halogen removal sorbents, suitable for integrated hot gas cleaning, are screened and some selected sorbents are tested in bench scale. Finally, halogen removal results are verified using the PDU-scale pressurised fluidized-bed gasification and integrated hot gas cleaning facilities of VTT. The project is part of the JOULE II Extension programme of the European Union. (author)

  8. Influence of Solvent-Solvent and Solute-Solvent Interaction Properties on Solvent-Mediated Potential

    Institute of Scientific and Technical Information of China (English)

    ZHOU Shi-Qi

    2005-01-01

    A recently proposed universal calculational recipe for solvent-mediated potential is applied to calculate excess potential of mean force between two large Lennard-Jones (LJ) or hard core attractive Yukawa particles immersed in small LJ solvent bath at supercritical state. Comparison between the present prediction with a hypernetted chain approximation adopted for solute-solute correlation at infinitely dilute limit and existing simulation data shows high accuracy for the region with large separation, and qualitative reliability for the solute particle contact region. The calculational simplicity of the present recipe allows for a detailed investigation on the effect of the solute-solvent and solvent-solvent interaction details on the excess potential of mean force. The resultant conclusion is that gathering of solvent particles near a solute particle leads to repulsive excess PMF, while depletion of solvent particles away from the solute particle leads to attractive excess PMF, and minor change of the solvent-solvent interaction range has large influence on the excess PMF.

  9. Integrating Social Neuroscience and Social Work: Innovations for Advancing Practice-Based Research

    Science.gov (United States)

    Matto, Holly C.; Strolin-Goltzman, Jessica

    2010-01-01

    Throughout the social work profession, there is ongoing interest in building a social science agenda that can address the complex practice-based questions faced by social work professionals today. Methodological innovations and unique funding opportunities have already significantly advanced research on social work practice. Still, there is…

  10. Special Features of the Advanced Loans Module of the ABCD Integrated Library System

    Science.gov (United States)

    de Smet, Egbert

    2011-01-01

    Purpose: The "advanced loans" module of the relatively new library software, ABCD, is an addition to the normal loans module and it offers a "generic transaction decision-making engine" functionality. The module requires extra installation effort and parameterisation, so this article aims to explain to the many potentially interested libraries,…

  11. Integrated Computer Aided Planning and Manufacture of Advanced Technology Jet Engines

    Directory of Open Access Journals (Sweden)

    B. K. Subhas

    1987-10-01

    Full Text Available This paper highlights an attempt at evolving a computer aided manufacturing system on a personal computer. A case study of an advanced technology jet engine component is included to illustrate various outputs from the system. The proposed system could be an alternate solution to sophisticated and expensive CAD/CAM workstations.

  12. Integrating movement in academic classrooms: understanding, applying and advancing the knowledge base.

    Science.gov (United States)

    Webster, C A; Russ, L; Vazou, S; Goh, T L; Erwin, H

    2015-08-01

    In the context of comprehensive and coordinated approaches to school health, academic classrooms have gained attention as a promising setting for increasing physical activity and reducing sedentary time among children. The aims of this paper are to review the rationale and knowledge base related to movement integration in academic classrooms, consider the practical applications of current knowledge to interventions and teacher education, and suggest directions for future research. Specifically, this paper (i) situates movement integration amid policy and research related to children's health and the school as a health-promoting environment; (ii) highlights the benefits of movement integration; (iii) summarizes movement integration programs and interventions; (iv) examines factors associated with classroom teachers' movement integration; (v) offers strategies for translating research to practice and (vi) forwards recommendations for future inquiry related to the effectiveness and sustainability of efforts to integrate movement into classroom routines. This paper provides a comprehensive resource for developing state-of-the-art initiatives to maximize children's movement in academic classrooms as a key strategy for important goals in both education and public health.

  13. Preliminary Data from an Advanced Dementia Consult Service: Integrating Research, Education, and Clinical Expertise

    Science.gov (United States)

    Catic, Angela G.; Mitchell, Susan L.

    2013-01-01

    Hospitalized patients with advanced dementia often receive care that is of limited clinical benefit and inconsistent with preferences. We designed an Advanced Dementia Consult Service and conducted a pre and post pilot study to evaluate it in a Boston hospital. Consults were conducted by geriatricians and palliative care nurse practitioner. They consisted of structured consultation, counseling and provision of an information booklet to the family, and post-discharge follow-up with the family and primary care providers. Patients > 65 admitted with advanced dementia were identified and consults were solicited using pop-ups programmed into the computerized provider order entry (POE) system. In the initial 3-month period, patients received usual care (N=24). In the subsequent 3-month period, consults were provided to patients for whom it was requested (N=5). Data were obtained from the electronic medical record and proxies interviews (admission, 1-month post-discharge). The patients’ mean age in the combined sample (N=29) was 85.4, 58.6% were from nursing homes, and 86.2% of their proxies stated comfort was the goal of care. Nonetheless, their hospitalizations were characterized by high rates of intravenous antibiotics (86.2%), > 5 venipunctures (44.8%), and radiological exams (96.6%). Acknowledging the small sample size, there were trends towards better outcomes in the intervention group including: higher proxy knowledge of the disease, greater communication between proxies and providers, more advance care planning, lower re-hospitalization rates, and fewer feeding tube insertions after discharge. Targeted consultation for advanced dementia is feasible and may promote greater engagement of proxies and goal-directed care for patients after discharge. PMID:24219202

  14. Continuous flow analytical microsystems based on low-temperature co-fired ceramic technology. Integrated potentiometric detection based on solvent polymeric ion-selective electrodes.

    Science.gov (United States)

    Ibanez-Garcia, Nuria; Mercader, Manel Bautista; Mendes da Rocha, Zaira; Seabra, Carlos Antonio; Góngora-Rubio, Mario Ricardo; Chamarro, Julian Alonso

    2006-05-01

    In this paper, the low-temperature co-fired ceramics (LTCC) technology, which has been commonly used for electronic applications, is presented as a useful alternative to construct continuous flow analytical microsystems. This technology enables not only the fabrication of complex three-dimensional structures rapidly and at a realistic cost but also the integration of the elements needed to carry out a whole analytical process, such as pretreatment steps, mixers, and detection systems. In this work, a simple and general procedure for the integration of ion-selective electrodes based on liquid ion exchanger is proposed and illustrated by using ammonium- and nitrate-selective membranes. Additionally, a screen-printed reference electrode was easily incorporated into the microfluidic LTCC structure allowing a complete on-chip integration of the potentiometric detection. Analytical features of the proposed systems are presented.

  15. A self-sustaining advanced lignocellulosic biofuel production by integration of anaerobic digestion and aerobic fungal fermentation.

    Science.gov (United States)

    Zhong, Yuan; Ruan, Zhenhua; Zhong, Yingkui; Archer, Steven; Liu, Yan; Liao, Wei

    2015-03-01

    High energy demand hinders the development and application of aerobic microbial biofuel production from lignocellulosic materials. In order to address this issue, this study focused on developing an integrated system including anaerobic digestion and aerobic fungal fermentation to convert corn stover, animal manure and food wastes into microbial lipids for biodiesel production. Dairy manure and food waste were first anaerobically digested to produce energy and solid digestate (AD fiber). AD fiber and corn stover were then processed by a combined alkali and acid hydrolysis, followed by fungal lipid accumulation. The integrated process can generate 1L biodiesel and 1.9 kg methane from 12.8 kg dry dairy manure, 3.1 kg dry food wastes and 12.2 kg dry corn stover with a positive net energy of 57 MJ, which concludes a self-sustaining lignocellulosic biodiesel process and provides a new route to co-utilize corn stover and organic wastes for advanced biofuel production.

  16. Advanced Stirling Convertor Dual Convertor Controller Testing at NASA Glenn Research Center in the Radioisotope Power Systems System Integration Laboratory

    Science.gov (United States)

    Dugala, Gina M.; Taylor, Linda M.; Bell, Mark E.; Dolce, James L.; Fraeman, Martin; Frankford, David P.

    2015-01-01

    NASA Glenn Research Center developed a nonnuclear representation of a Radioisotope Power System (RPS) consisting of a pair of Advanced Stirling Convertors (ASCs), Dual Convertor Controller (DCC) EMs (engineering models) 2 and 3, and associated support equipment, which were tested in the Radioisotope Power Systems System Integration Laboratory (RSIL). The DCC was designed by the Johns Hopkins University Applied Physics Laboratory (JHU/APL) to actively control a pair of ASCs. The first phase of testing included a Dual Advanced Stirling Convertor Simulator (DASCS), which was developed by JHU/APL and simulates the operation and electrical behavior of a pair of ASCs in real time via a combination of hardware and software. RSIL provides insight into the electrical interactions between a representative radioisotope power generator, its associated control schemes, and realistic electric system loads. The first phase of integration testing included the following spacecraft bus configurations: capacitive, battery, and super-capacitor. A load profile, created based on data from several missions, tested the RPS's and RSIL's ability to maintain operation during load demands above and below the power provided by the RPS. The integration testing also confirmed the DCC's ability to disconnect from the spacecraft when the bus voltage dipped below 22 volts or exceeded 36 volts. Once operation was verified with the DASCS, the tests were repeated with actual operating ASCs. The goal of this integration testing was to verify operation of the DCC when connected to a spacecraft and to verify the functionality of the newly designed RSIL. The results of these tests are presented in this paper.

  17. Integrating social neuroscience and social work: innovations for advancing practice-based research.

    Science.gov (United States)

    Matto, Holly C; Strolin-Goltzman, Jessica

    2010-04-01

    Throughout the social work profession, there is ongoing interest in building a social science agenda that can address the complex practice-based questions faced by social work professionals today. Methodological innovations and unique funding opportunities have already significantly advanced research on social work practice. Still, there is enthusiastic discussion of how to ensure that such capacity development helps the profession move forward in ways that make use of the biological sciences and that facilitate social work-specific contributions to the larger interdisciplinary scientific community. This article describes how the social work profession can make use of biomedical knowledge and technological advances from social neuroscience to inform psychosocial treatment development, and it illustrates an application to social work practice by giving an example of a substance abuse treatment development process built on social neuroscientific research.

  18. Controlling Actinide Hydration in Mixed Solvent Systems: Towards Tunable Solvent Systems to Close the Fuel Cycle

    Energy Technology Data Exchange (ETDEWEB)

    Clark, Sue B. [Washington State Univ., Pullman, WA (United States). Dept. of Chemistry

    2016-10-31

    The goal of this project has been to define the extent of hydration the f-elements and other cations in mixed solvent electrolyte systems. Methanol-water and other mixed solvent systems have been studied, where the solvent dielectric constant was varied systematically. Thermodynamic and spectroscopic studies provide details concerning the energetics of complexation and other reactions of these cations. This information has also been used to advance new understanding of the behavior of these cations in a variety of systems, ranging from environmental studies, chromatographic approaches, and ionization processes for mass spectrometry.

  19. NCD Diamond Semiconductor System for Advanced Power Electronics Systems Integration : CRADA report

    Energy Technology Data Exchange (ETDEWEB)

    Sumant, Anirudha [AKHAN Semiconductor, Inc., Hoffman Estates, IL (United States)

    2016-07-22

    The integration of 2D materials such as molybdenum disulphide (MoS2) with diamond (3D) was achieved by forming an heterojunction between these two materials and its electrical performance was studied experimentally. The device charactertics did show good rectifying nature when p-type single crystal diamond was integrated with n-type MoS2. These results are very encouraging indicating possible applications in semiconductor electronics, however further studies are required for a detailed understanding of the transport phenomena at the MoS2/diamond interface.

  20. Guidelines for Implementing Advanced Distribution Management Systems-Requirements for DMS Integration with DERMS and Microgrids

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Jianhui [Argonne National Lab. (ANL), Argonne, IL (United States); Chen, Chen [Argonne National Lab. (ANL), Argonne, IL (United States); Lu, Xiaonan [Argonne National Lab. (ANL), Argonne, IL (United States)

    2015-08-01

    This guideline focuses on the integration of DMS with DERMS and microgrids connected to the distribution grid by defining generic and fundamental design and implementation principles and strategies. It starts by addressing the current status, objectives, and core functionalities of each system, and then discusses the new challenges and the common principles of DMS design and implementation for integration with DERMS and microgrids to realize enhanced grid operation reliability and quality power delivery to consumers while also achieving the maximum energy economics from the DER and microgrid connections.

  1. Alternative Green Solvents Project

    Science.gov (United States)

    Maloney, Phillip R.

    2012-01-01

    Necessary for safe and proper functioning of equipment. Mainly halogenated solvents. Tetrachloride, Trichloroethylene (TCE), CFC-113. No longer used due to regulatory/safety concerns. Precision Cleaning at KSC: Small % of total parts. Used for liquid oxygen (LOX) systems. Dual solvent process. Vertrel MCA (decafluoropentane (DFP) and trons-dichloroethylene) HFE-7100. DFP has long term environmental concerns. Project Goals: a) Identify potential replacements. b) 22 wet chemical processes. c) 3 alternative processes. d) Develop test procedures. e) Contamination and cleaning. f) Analysis. g) Use results to recommend alternative processes. Conclusions: a) No alternative matched Vertrel in this study. b) No clear second place solvent. c) Hydrocarbons- easy; Fluorinated greases- difficult. d) Fluorinated component may be needed in replacement solvent. e) Process may need to make up for shortcoming of the solvent. f) Plasma and SCC02 warrant further testing.

  2. Integrating Syntax, Semantics, and Discourse DARPA (Defense Advanced Research Projects Agency) Natural Language Understanding Program

    Science.gov (United States)

    1988-08-01

    resolution of anaphoric references, and an analysis of temporal relations. The resulting data structure is known as the Integrated Discourse Representation... binding procedures * semantics.pl - the Semantic Interpreter * world.pl - general knowledge base procedures - Pragmatics * discourse-rules.pl - manage

  3. Advanced low-energy building at Innsbruck. Integral concept; Niedrigenergie-Neubau in Innsbruck. Integrales Konzept

    Energy Technology Data Exchange (ETDEWEB)

    Waldhoff, C.; Lenzen, B.; Schrag, T.; Raedler, J. [Dezentral - Energiekonzepte und Gebaeudesimulationen Waldhoff Raedler Lenzen Schrag GbR, Berlin (Germany)

    2006-04-15

    The new administrative building of the Tyrol state government integrates architecture, utilisation and technical facilities into an optimized overall system. Thermal simulations were used in the project in order to achieve optimum energy efficiency and thermal comfort. The building has a surface of about 11,000 m{sup 2}; the total cost was about 21 million Euros. (orig.)

  4. Leadership Education Is Not Enough: Advancing an Integrated Model of Student-Athlete Development

    Science.gov (United States)

    DiPaolo, Donald G.

    2017-01-01

    This article advocates a new approach to how we work with the millions of student-athletes in schools by examining a more holistic model of player development. Rather than assisting students in separate silos and initiatives, the argument is made for integrating the areas of leadership education, performance psychology, and personal development…

  5. Silicon Compatible Materials, Processes, and Technologies for Advanced Integrated Circuits and Emerging Applications 6

    NARCIS (Netherlands)

    Roozeboom, F.; Narayanan, V.; Kakushima, K.; Timans, P.J.; Gusev, E.P.; Karim, Z.; Gendt, S. De

    2016-01-01

    The topics of this annual symposium continue to describe the evolution of traditional scaling in CMOS integrated circuit manufacturing (More Moore for short), combined with the opportunities from growing diversification and embedded functionality (More than Moore). Once again, the main objective was

  6. Advances in directed self assembly integration and manufacturability at 300 mm

    Science.gov (United States)

    Rathsack, Benjamen; Somervell, Mark; Muramatsu, Makato; Tanouchi, Keiji; Kitano, Takahiro; Nishimura, Eiichi; Yatsuda, Koichi; Nagahara, Seiji; Iwaki, Hiroyuki; Akai, Keiji; Ozawa, Mariko; Romo Negreira, Ainhoa; Tahara, Shigeru; Nafus, Kathleen

    2013-03-01

    Directed self-assembly (DSA) has the potential to extend scaling for both line/space and hole patterns. DSA has shown the capability for pitch reduction (multiplication), hole shrinks, CD self-healing as well as a pathway towards LWR and pattern collapse improvement [1-10]. TEL has developed a DSA development ecosystem (collaboration with customers, consortia, inspection vendors and material suppliers) to successfully demonstrate directed PS-PMMA DSA patterns using chemo-epitaxy (lift-off and etch guide) and grapho-epitaxy integrations on 300 mm wafers. New processes are being developed to simplify process integration, to reduce defects and to address design integration challenges with the long term goal of robust manufacturability. For hole DSA applications, a wet development process has been developed that enables traditional post-develop metrology through the high selectivity removal of PMMA cylindrical cores. For line/ space DSA applications, new track, cleans and etch processes have been developed to improve manufacturability. In collaboration with universities and consortia, fundamental process studies and simulations are used to drive process improvement and defect investigation. To extend DSA resolution beyond a PS-PMMA system, high chi materials and processes are also explored. In this paper, TEL's latest process solutions for both hole and line/space DSA process integrations are presented.

  7. A flexible sulfur-graphene-polypropylene separator integrated electrode for advanced Li-S batteries.

    Science.gov (United States)

    Zhou, Guangmin; Li, Lu; Wang, Da-Wei; Shan, Xu-Yi; Pei, Songfeng; Li, Feng; Cheng, Hui-Ming

    2015-01-27

    A flexible Li-S battery based on an integrated structure of sulfur and graphene on a separator is developed. The internal graphene current collector offers a continuous conductive pathway, a modified interface with sulfur, and a good barrier to and an effective reservoir for dissolved polysulfides, consequently improving the capacity and cyclic life of the Li-S battery.

  8. Advancing Integrated Pest Management for Dermanyssus gallinae in laying hen facilities

    NARCIS (Netherlands)

    Mul, Monique F.

    2017-01-01

    Pest and diseases in agricultural systems reduce the yield and quality of available food and feed worldwide. To meet the global growing demand for these products, losses should be reduced, preferably in a sustainable way. Integrated Pest Management (IPM) is a sustaina

  9. Advancing Coordination Between DRM and CCA in Integrated Flood Risk Management

    DEFF Research Database (Denmark)

    Jebens, Martin; Sørensen, Carlo Sass

    lack of planning and awareness. This, we argue, may be the golden opportunity to improve the national DRM-CCA integration. Past coastal risk mitigation and adaptation in Denmark only focused on structural measures. Due to a long coastline this is neither a sustainable nor an economically feasible...

  10. Technologies for Inclusive Education: Beyond Traditional Integration Approaches. Advances in Educational Technologies and Instructional Design

    Science.gov (United States)

    Barres, David Griol; Carrion, Zoraida Callejas; Lopez-Cozar Delgado, Ramon

    2013-01-01

    By providing students with the opportunities to receive a high quality education regardless of their social or cultural background, inclusive education is a new area that goes beyond traditional integration approaches. These approaches hope to provide the educative system with the ability to adapt to the diversity of its students. Technologies for…

  11. Advances in three-dimensional integral imaging: sensing, display, and applications [Invited].

    Science.gov (United States)

    Xiao, Xiao; Javidi, Bahram; Martinez-Corral, Manuel; Stern, Adrian

    2013-02-01

    Three-dimensional (3D) sensing and imaging technologies have been extensively researched for many applications in the fields of entertainment, medicine, robotics, manufacturing, industrial inspection, security, surveillance, and defense due to their diverse and significant benefits. Integral imaging is a passive multiperspective imaging technique, which records multiple two-dimensional images of a scene from different perspectives. Unlike holography, it can capture a scene such as outdoor events with incoherent or ambient light. Integral imaging can display a true 3D color image with full parallax and continuous viewing angles by incoherent light; thus it does not suffer from speckle degradation. Because of its unique properties, integral imaging has been revived over the past decade or so as a promising approach for massive 3D commercialization. A series of key articles on this topic have appeared in the OSA journals, including Applied Optics. Thus, it is fitting that this Commemorative Review presents an overview of literature on physical principles and applications of integral imaging. Several data capture configurations, reconstruction, and display methods are overviewed. In addition, applications including 3D underwater imaging, 3D imaging in photon-starved environments, 3D tracking of occluded objects, 3D optical microscopy, and 3D polarimetric imaging are reviewed.

  12. Integrated Design for Manufacturing of Braided Preforms for Advanced Composites Part I: 2D Braiding

    Science.gov (United States)

    Gao, Yan Tao; Ko, Frank K.; Hu, Hong

    2013-12-01

    This paper presents a 2D braiding design system for advanced textile structural composites was based on dynamic models. A software package to assist in the design of braided preform manufacturing has been developed. The package allows design parameters (machine speeds, fiber volume fraction, tightness factor, etc.) to be easily obtained and the relationships between said parameters to be demonstrated graphically. The fabirc geometry model (FGM) method was adopted to evaluate the mechanical properties of the composites. Experimental evidence demonstrates the success of the use of dynamic models in the design software for the manufacture of braided fabric preforms.

  13. Pilot vehicle interface on the advanced fighter technology integration F-16

    Science.gov (United States)

    Dana, W. H.; Smith, W. B.; Howard, J. D.

    1986-01-01

    This paper focuses on the work load aspects of the pilot vehicle interface in regard to the new technologies tested during AMAS Phase II. Subjects discussed in this paper include: a wide field-of-view head-up display; automated maneuvering attack system/sensor tracker system; master modes that configure flight controls and mission avionics; a modified helmet mounted sight; improved multifunction display capability; a voice interactive command system; ride qualities during automated weapon delivery; a color moving map; an advanced digital map display; and a g-induced loss-of-consciousness and spatial disorientation autorecovery system.

  14. Advanced control strategies to integrate German offshore wind potential into electrical energy sypply

    Energy Technology Data Exchange (ETDEWEB)

    Rohrig, K.; Schloegl, F.; Jursa, R.; Wolff, M. [Institut fuer Solare Energieversorgungstechnik (ISET), Kassel (Germany); Fischer, F.; Hartge, S. [ENERCON GmbH, Aurich (Germany); Valov, B.; Heier, S. [Kassel Univ. (Gesamthochschule) (Germany)

    2005-07-01

    The paper describes the technical status and presents new concepts, models and approaches for the technical assistance of large scale wind power integration into the electrical energy supply system in Germany. It shows the technical and economic problems with the integration of high penetration of wind power plant in the network and the total electrical system. After an analysis of the effects of increased wind power generation on system planning and grid operation, we discuss innovative operational control concepts for large (offshore) wind farms. These concepts will provide a multitude of new possibilities to enable simple, flexible and undisturbed reaction to the demands of participants (wind farm operators, grid operators). These operational control strategies are mainly based on ISETs successful employed wind power prediction tools, operated by all German TSO's, and will enable energy and power control, as well as the provision of reactive power, in order to achieve comparable properties to conventional power plant types. (orig.)

  15. Advances in gallium arsenide monolithic microwave integrated-circuit technology for space communications systems

    Science.gov (United States)

    Bhasin, K. B.; Connolly, D. J.

    1986-01-01

    Future communications satellites are likely to use gallium arsenide (GaAs) monolithic microwave integrated-circuit (MMIC) technology in most, if not all, communications payload subsystems. Multiple-scanning-beam antenna systems are expected to use GaAs MMIC's to increase functional capability, to reduce volume, weight, and cost, and to greatly improve system reliability. RF and IF matrix switch technology based on GaAs MMIC's is also being developed for these reasons. MMIC technology, including gigabit-rate GaAs digital integrated circuits, offers substantial advantages in power consumption and weight over silicon technologies for high-throughput, on-board baseband processor systems. In this paper, current developments in GaAs MMIC technology are described, and the status and prospects of the technology are assessed.

  16. Advancing the Automated Design of Integrated Intelligent Multi-Sensory Systems with Self-X Properties

    OpenAIRE

    Thongpull, Kittikhun

    2016-01-01

    The recently established technologies in the areas of distributed measurement and intelligent information processing systems, e.g., Cyber Physical Systems (CPS), Ambient Intelligence/Ambient Assisted Living systems (AmI/AAL), the Internet of Things (IoT), and Industry 4.0 have increased the demand for the development of intelligent integrated multi-sensory systems as to serve rapid growing markets [1, 2]. These increase the significance of complex measurement systems, that inco...

  17. Integration of CFD codes and advanced combustion models for quantitative burnout determination

    Energy Technology Data Exchange (ETDEWEB)

    Javier Pallares; Inmaculada Arauzo; Alan Williams [University of Zaragoza, Zaragoza (Spain). Centre of Research for Energy Resources and Consumption (CIRCE)

    2007-10-15

    CFD codes and advanced kinetics combustion models are extensively used to predict coal burnout in large utility boilers. Modelling approaches based on CFD codes can accurately solve the fluid dynamics equations involved in the problem but this is usually achieved by including simple combustion models. On the other hand, advanced kinetics combustion models can give a detailed description of the coal combustion behaviour by using a simplified description of the flow field, this usually being obtained from a zone-method approach. Both approximations describe correctly general trends on coal burnout, but fail to predict quantitative values. In this paper a new methodology which takes advantage of both approximations is described. In the first instance CFD solutions were obtained of the combustion conditions in the furnace in the Lamarmora power plant (ASM Brescia, Italy) for a number of different conditions and for three coals. Then, these furnace conditions were used as inputs for a more detailed chemical combustion model to predict coal burnout. In this, devolatilization was modelled using a commercial macromolecular network pyrolysis model (FG-DVC). For char oxidation an intrinsic reactivity approach including thermal annealing, ash inhibition and maceral effects, was used. Results from the simulations were compared against plant experimental values, showing a reasonable agreement in trends and quantitative values. 28 refs., 4 figs., 4 tabs.

  18. The integration of anthracyclines in the treatment of advanced ovarian cancer.

    Science.gov (United States)

    Lück, H J; Du Bois, A; Weber, B; Pfisterer, J; Goupil, A; Kuhn, W; Barats, J C; Blohmer, J; Mousseau, M; Schröder, W; Meier, W; Möbus, V; Richter, B

    2001-01-01

    Since the publication of the Gynecologic Oncology Group (GOG) protocol 111 in 1996, and the results of the Arbeitgemeinschaft Gyna kologische Onkologie (AGO) trial Ovar-3 and the GOG protocol 158, the combination of platinum and paclitaxel has been adopted as the standard therapy in advanced ovarian cancer. One option for achieving further progress in the first-line treatment of advanced ovarian cancer might be the addition of noncross-resistant drugs to the two-drug regimen. Meta-analysis showed a survival benefit for platinum-anthracycline based combinations as compared to platinum-based combinations without anthracyclines. An AGO phase I/II trial compared epirubicin in combination with carboplatin and paclitaxel in untreated patients with gynecological malignancies. Based on the results of this study a randomized phase III trial together with the French GINECO group was conducted. The trial started 11/97 and was closed 11/99. All 1281 patients were randomized. Currently, 1132 end-of-therapy reports have been issued. Nine hundred eighty nine (87%) patients completed six cycles of treatment. Treatment and toxicity data are available for these patients. Three hundred thirty five patients had a measurable residual tumor after initial debulking surgery. Response data of 228 patients (111 ET-Carbo, 117 Carbo-T) are available.

  19. Advances and challenges in logical modeling of cell cycle regulation: perspective for multi-scale, integrative yeast cell models.

    Science.gov (United States)

    Barberis, Matteo; Todd, Robert G; van der Zee, Lucas

    2017-01-01

    The eukaryotic cell cycle is robustly designed, with interacting molecules organized within a definite topology that ensures temporal precision of its phase transitions. Its underlying dynamics are regulated by molecular switches, for which remarkable insights have been provided by genetic and molecular biology efforts. In a number of cases, this information has been made predictive, through computational models. These models have allowed for the identification of novel molecular mechanisms, later validated experimentally. Logical modeling represents one of the youngest approaches to address cell cycle regulation. We summarize the advances that this type of modeling has achieved to reproduce and predict cell cycle dynamics. Furthermore, we present the challenge that this type of modeling is now ready to tackle: its integration with intracellular networks, and its formalisms, to understand crosstalks underlying systems level properties, ultimate aim of multi-scale models. Specifically, we discuss and illustrate how such an integration may be realized, by integrating a minimal logical model of the cell cycle with a metabolic network.

  20. Gravity Spy: Integrating Advanced LIGO Detector Characterization, Machine Learning, and Citizen Science

    CERN Document Server

    Zevin, Michael; Bahaadini, Sara; Besler, Emre; Rohani, Neda; Allen, Sarah; Cabero, Miriam; Crowston, Kevin; Katsaggelos, Aggelos; Larson, Shane; Lee, Tae Kyoung; Lintott, Chris; Littenberg, Tyson; Lundgren, Andrew; Oesterlund, Carsten; Smith, Joshua; Trouille, Laura; Kalogera, Vicky

    2016-01-01

    (abridged for arXiv) With the first direct detection of gravitational waves, the Advanced Laser Interferometer Gravitational-wave Observatory (LIGO) has initiated a new field of astronomy by providing an alternate means of sensing the universe. The extreme sensitivity required to make such detections is achieved through exquisite isolation of all sensitive components of LIGO from non-gravitational-wave disturbances. Nonetheless, LIGO is still susceptible to a variety of instrumental and environmental sources of noise that contaminate the data. Of particular concern are noise features known as glitches, which are transient and non-Gaussian in their nature, and occur at a high enough rate so that accidental coincidence between the two LIGO detectors is non-negligible. In this paper we describe an innovative project that combines crowdsourcing with machine learning to aid in the challenging task of categorizing all of the glitches recorded by the LIGO detectors. Through the Zooniverse platform, we engage and rec...

  1. Advance and Economic Benefit Made in Petroleum Integrated Exploration of CNPC

    Institute of Scientific and Technical Information of China (English)

    Deng Longwu; Guo Qianjie

    1996-01-01

    @@ The modern integrated petroleum exploration method,consisting of basin analysis and simulation, description and assessment of traps and description and assessment of oil/gas reservoirs, is a key component of the modern petroleum exploration system. With a deepening understanding of the modern petroleum exploration method, more and more attention has been paid to basin analysing and simulating, trap description and assessment and oil/gas reservoir description and assessment in the oil fields of China National Petroleum Corporation (CNPC),encouraging results and precious experience have been achieved.

  2. Nationwide Buildings Energy Research enabled through an integrated Data Intensive Scientific Workflow and Advanced Analysis Environment

    Energy Technology Data Exchange (ETDEWEB)

    Kleese van Dam, Kerstin [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Lansing, Carina S. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Elsethagen, Todd O. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hathaway, John E. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Guillen, Zoe C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Dirks, James A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Skorski, Daniel C. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Stephan, Eric G. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Gorrissen, Willy J. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Gorton, Ian [Carnegie Mellon Univ., Pittsburgh, PA (United States); Liu, Yan [Concordia Univ., Montreal, QC (Canada)

    2014-01-28

    Modern workflow systems enable scientists to run ensemble simulations at unprecedented scales and levels of complexity, allowing them to study system sizes previously impossible to achieve, due to the inherent resource requirements needed for the modeling work. However as a result of these new capabilities the science teams suddenly also face unprecedented data volumes that they are unable to analyze with their existing tools and methodologies in a timely fashion. In this paper we will describe the ongoing development work to create an integrated data intensive scientific workflow and analysis environment that offers researchers the ability to easily create and execute complex simulation studies and provides them with different scalable methods to analyze the resulting data volumes. The integration of simulation and analysis environments is hereby not only a question of ease of use, but supports fundamental functions in the correlated analysis of simulation input, execution details and derived results for multi-variant, complex studies. To this end the team extended and integrated the existing capabilities of the Velo data management and analysis infrastructure, the MeDICi data intensive workflow system and RHIPE the R for Hadoop version of the well-known statistics package, as well as developing a new visual analytics interface for the result exploitation by multi-domain users. The capabilities of the new environment are demonstrated on a use case that focusses on the Pacific Northwest National Laboratory (PNNL) building energy team, showing how they were able to take their previously local scale simulations to a nationwide level by utilizing data intensive computing techniques not only for their modeling work, but also for the subsequent analysis of their modeling results. As part of the PNNL research initiative PRIMA (Platform for Regional Integrated Modeling and Analysis) the team performed an initial 3 year study of building energy demands for the US Eastern

  3. Separations and safeguards model integration.

    Energy Technology Data Exchange (ETDEWEB)

    Cipiti, Benjamin B.; Zinaman, Owen

    2010-09-01

    Research and development of advanced reprocessing plant designs can greatly benefit from the development of a reprocessing plant model capable of transient solvent extraction chemistry. This type of model can be used to optimize the operations of a plant as well as the designs for safeguards, security, and safety. Previous work has integrated a transient solvent extraction simulation module, based on the Solvent Extraction Process Having Interaction Solutes (SEPHIS) code developed at Oak Ridge National Laboratory, with the Separations and Safeguards Performance Model (SSPM) developed at Sandia National Laboratory, as a first step toward creating a more versatile design and evaluation tool. The goal of this work was to strengthen the integration by linking more variables between the two codes. The results from this integrated model show expected operational performance through plant transients. Additionally, ORIGEN source term files were integrated into the SSPM to provide concentrations, radioactivity, neutron emission rate, and thermal power data for various spent fuels. This data was used to generate measurement blocks that can determine the radioactivity, neutron emission rate, or thermal power of any stream or vessel in the plant model. This work examined how the code could be expanded to integrate other separation steps and benchmark the results to other data. Recommendations for future work will be presented.

  4. SCENARIOS EVALUATION TOOL FOR CHLORINATED SOLVENT MNA

    Energy Technology Data Exchange (ETDEWEB)

    Vangelas, K; Brian02 Looney, B; Michael J. Truex; Charles J. Newell

    2006-08-16

    Over the past three decades, much progress has been made in the remediation of chlorinated solvents from the subsurface. Yet these pervasive contaminants continue to present a significant challenge to the U.S. Department of Energy (DOE), other federal agencies, and other public and private organizations. The physical and chemical properties of chlorinated solvents make it difficult to rapidly reach the low concentrations typically set as regulatory limits. These technical challenges often result in high costs and long remediation time frames. In 2003, the DOE through the Office of Environmental Management funded a science-based technical project that uses the U.S. Environmental Protection Agency's technical protocol (EPA, 1998) and directives (EPA, 1999) on Monitored Natural Attenuation (MNA) as the foundation on which to introduce supporting concepts and new scientific developments that will support remediation of chlorinated solvents based on natural attenuation processes. This project supports the direction in which many site owners want to move to complete the remediation of their site(s), that being to complete the active treatment portion of the remedial effort and transition into MNA. The overarching objective of the effort was to examine environmental remedies that are based on natural processes--remedies such as Monitored Natural Attenuation (MNA) or Enhanced Attenuation (EA). The research program did identify several specific opportunities for advances based on: (1) mass balance as the central framework for attenuation based remedies, (2) scientific advancements and achievements during the past ten years, (3) regulatory and policy development and real-world experience using MNA, and (4) exploration of various ideas for integrating attenuation remedies into a systematic set of ''combined remedies'' for contaminated sites. These opportunities are summarized herein and are addressed in more detail in referenced project documents and

  5. Application Evaluation of Air-Sparging and Aerobic Bioremediation in PAM(Physical Aquifer Model) with Advanced and Integrated Module

    Science.gov (United States)

    Hong, U.; Ko, J.; Park, S.; Kim, Y.; Kwon, S.; Ha, J.; Lim, J.; Han, K.

    2010-12-01

    It is generally difficult for a single process to remediate contaminated soil and groundwater contaminated with various organic compounds such as total petroleum hydrocarbon (TPH), benzene, toluene, ethylbenzene, xylene (BTEX), chlorinated aliphatic hydrocarbons (CAHs) because those contaminants show different chemical properties in two phases (e.g. soil and groundwater). Therefore, it is necessary to design an in-situ remediation system which can remove various contaminants simultaneously. For the purpose, we constructed integrated well module which can apply several remediation process such as air sparging, soil vapor extraction, and bioventing. The advanced integrated module consisted of three main parts such as head, body, and end cap. First of all, head part has three 3.6-cm-diameter stainless lines and can simultaneously inject air or extract NAPL, respectively. Secondly, body part has two 10-cm-height screen intervals with 100-mesh stainless inserts for unsaturated and smear zone. Lastly, we constructed three different sizes of end caps for injection and extraction from a saturated zone. We assumed that the integrated module can play bioremediation, air sparging, cometabolic sparging, chemical oxidation. In this study, we examined application of air sparing and aerobic bioremediation of toluene in Physical Aquifer Model (PAM) with an integrated well module. During air sparging experiments, toluene concentration decreased by injection of air. In addition, we accomplished bioremediation experiment to evaluate removal of toluene by indigenous microbes in PAM with continuous air injection. From the two experiments result, we confirmed that air sparging and aerobic bioremediation processes can be simultaneously carried out by an intergrated well module.

  6. Advances in the integration of transcriptional regulatory information into genome-scale metabolic models.

    Science.gov (United States)

    Vivek-Ananth, R P; Samal, Areejit

    2016-09-01

    A major goal of systems biology is to build predictive computational models of cellular metabolism. Availability of complete genome sequences and wealth of legacy biochemical information has led to the reconstruction of genome-scale metabolic networks in the last 15 years for several organisms across the three domains of life. Due to paucity of information on kinetic parameters associated with metabolic reactions, the constraint-based modelling approach, flux balance analysis (FBA), has proved to be a vital alternative to investigate the capabilities of reconstructed metabolic networks. In parallel, advent of high-throughput technologies has led to the generation of massive amounts of omics data on transcriptional regulation comprising mRNA transcript levels and genome-wide binding profile of transcriptional regulators. A frontier area in metabolic systems biology has been the development of methods to integrate the available transcriptional regulatory information into constraint-based models of reconstructed metabolic networks in order to increase the predictive capabilities of computational models and understand the regulation of cellular metabolism. Here, we review the existing methods to integrate transcriptional regulatory information into constraint-based models of metabolic networks.

  7. Recent advances in nanoplasmonic biosensors: applications and lab-on-a-chip integration

    Directory of Open Access Journals (Sweden)

    Lopez Gerardo A.

    2016-08-01

    Full Text Available Motivated by the recent progress in the nanofabrication field and the increasing demand for cost-effective, portable, and easy-to-use point-of-care platforms, localized surface plasmon resonance (LSPR biosensors have been subjected to a great scientific interest in the last few years. The progress observed in the research of this nanoplasmonic technology is remarkable not only from a nanostructure fabrication point of view but also in the complete development and integration of operative devices and their application. The potential benefits that LSPR biosensors can offer, such as sensor miniaturization, multiplexing opportunities, and enhanced performances, have quickly positioned them as an interesting candidate in the design of lab-on-a-chip (LOC optical biosensor platforms. This review covers specifically the most significant achievements that occurred in recent years towards the integration of this technology in compact devices, with views of obtaining LOC devices. We also discuss the most relevant examples of the use of the nanoplasmonic biosensors for real bioanalytical and clinical applications from assay development and validation to the identification of the implications, requirements, and challenges to be surpassed to achieve fully operative devices.

  8. Measure and integration an advanced course in basic procedures and applications

    CERN Document Server

    König, Heinz

    1997-01-01

    This book sets out to restructure certain fundamentals in measure and integration theory, and thus to fee the theory from some notorious drawbacks. It centers around the ubiquitous task of producing appropriate contents and measures from more primitive data, in order to extend elementary contents and to represent elementary integrals. This task has not been met with adequate unified means so far. The traditional main tools, the Carathéodory and Daniell-Stone theorems, are too restrictive and had to be supplemented by other ad-hoc procedures. Around 1970 a new approach emerged, based on the notion of regularity, which in traditional measure theory is linked to topology. The present book develops the new approach into a systematic theory. The theory unifies the entire context and is much more powerful than the former means. It has striking implications all over measure theory and beyond. Thus it extends the Riesz representation theorem in terms of Randon measures from locally compact to arbitrary Hausdorff top...

  9. Recent advances in nanoplasmonic biosensors: applications and lab-on-a-chip integration

    Science.gov (United States)

    Lopez, Gerardo A.; Estevez, M.-Carmen; Soler, Maria; Lechuga, Laura M.

    2017-01-01

    Motivated by the recent progress in the nanofabrication field and the increasing demand for cost-effective, portable, and easy-to-use point-of-care platforms, localized surface plasmon resonance (LSPR) biosensors have been subjected to a great scientific interest in the last few years. The progress observed in the research of this nanoplasmonic technology is remarkable not only from a nanostructure fabrication point of view but also in the complete development and integration of operative devices and their application. The potential benefits that LSPR biosensors can offer, such as sensor miniaturization, multiplexing opportunities, and enhanced performances, have quickly positioned them as an interesting candidate in the design of lab-on-a-chip (LOC) optical biosensor platforms. This review covers specifically the most significant achievements that occurred in recent years towards the integration of this technology in compact devices, with views of obtaining LOC devices. We also discuss the most relevant examples of the use of the nanoplasmonic biosensors for real bioanalytical and clinical applications from assay development and validation to the identification of the implications, requirements, and challenges to be surpassed to achieve fully operative devices.

  10. Integration Process Development for Improved Compatibility with Organic Non-Porous Ultralow-k Dielectric Fluorocarbon on Advanced Cu Interconnects

    Science.gov (United States)

    Gu, Xun; Tomita, Yugo; Nemoto, Takenao; Miyatani, Kotaro; Saito, Akane; Kobayashi, Yasuo; Teramoto, Akinobu; Kuroda, Rihito; Kuroki, Shin-Ichiro; Kawase, Kazumasa; Nozawa, Toshihisa; Matsuoka, Takaaki; Sugawa, Shigetoshi; Ohmi, Tadahiro

    2012-05-01

    Integration of an organic non-porous ultralow-k dielectric, fluorocarbon (k= 2.2), into advanced Cu interconnects was demonstrated. The challenges of process-induced damage, such as delamination and variances of both the structure and electrical properties of the fluorocarbon during fabrication, were investigated on Cu/fluorocarbon damascene interconnects. A titanium-based barrier layer, instead of a tantalum-based barrier layer, was used to avoid delamination between Cu and fluorocarbon in Cu/fluorocarbon interconnects. A moisture-hermetic dielectric protective layer was also effective to avoid damage induced by wet chemical cleaning. On the other hand, a post-etching nitrogen plasma treatment to form a stable protective layer on the surface of the fluorocarbon was proposed for the practical minimization of damage introduction to fluorocarbon in the following damascene process, such as post-etching cleaning.

  11. Cleaning without chlorinated solvents

    Energy Technology Data Exchange (ETDEWEB)

    Thompson, L.M.; Simandl, R.F.

    1994-12-31

    Because of health and environmental concerns, many regulations have been passed in recent years regarding the use of chlorinated solvents. The Oak Ridge Y-12 Plant has had an active program to find alternatives for these solvents used in cleaning applications for the past 7 years. During this time frame, the quantity of solvents purchased has been reduced by 92%. The program has been a twofold effort. Vapor degreasers used in batch cleaning-operations have been replaced by ultrasonic cleaning with aqueous detergent, and other organic solvents have been identified for use in hand-wiping or specialty operations. In order to qualify these alternatives for use, experimentation was conducted on cleaning ability as well as effects on subsequent operations such as welding, painting and bonding. Cleaning ability was determined using techniques such as X-ray photoelectron spectroscopy (XPS) and Fourier Transform Infrared Spectroscopy (FTIR) which are capable of examining monolayer levels of contamination on a surface. Solvents have been identified for removal of rust preventative oils, lapping oils, machining coolants, lubricants, greases, and mold releases. Solvents have also been evaluated for cleaning urethane foam spray guns, swelling of urethanes and swelling of epoxies.

  12. 3D Navigation and Integrated Hazard Display in Advanced Avionics: Workload, Performance, and Situation Awareness

    Science.gov (United States)

    Wickens, Christopher D.; Alexander, Amy L.

    2004-01-01

    We examined the ability for pilots to estimate traffic location in an Integrated Hazard Display, and how such estimations should be measured. Twelve pilots viewed static images of traffic scenarios and then estimated the outside world locations of queried traffic represented in one of three display types (2D coplanar, 3D exocentric, and split-screen) and in one of four conditions (display present/blank crossed with outside world present/blank). Overall, the 2D coplanar display best supported both vertical (compared to 3D) and lateral (compared to split-screen) traffic position estimation performance. Costs of the 3D display were associated with perceptual ambiguity. Costs of the split screen display were inferred to result from inappropriate attention allocation. Furthermore, although pilots were faster in estimating traffic locations when relying on memory, accuracy was greatest when the display was available.

  13. Advances in environmental genomics: towards an integrated view of micro-organisms and ecosystems.

    Science.gov (United States)

    Bertin, Philippe N; Médigue, Claudine; Normand, Philippe

    2008-02-01

    Microbial genome sequencing has, for the first time, made accessible all the components needed for both the elaboration and the functioning of a cell. Associated with other global methods such as protein and mRNA profiling, genomics has considerably extended our knowledge of physiological processes and their diversity not only in human, animal and plant pathogens but also in environmental isolates. At a higher level of complexity, the so-called meta approaches have recently shown great promise in investigating microbial communities, including uncultured micro-organisms. Combined with classical methods of physico-chemistry and microbiology, these endeavours should provide us with an integrated view of how micro-organisms adapt to particular ecological niches and participate in the dynamics of ecosystems.

  14. Potential for integrated optical circuits in advanced aircraft with fiber optic control and monitoring systems

    Science.gov (United States)

    Baumbick, Robert

    1991-01-01

    The current Fiber Optic Control System Integration (FOCSI) program is reviewed and the potential role of IOCs in FOCSI applications is described. The program is intended for building, environmentally testing, and demonstrating operation in piggyback flight tests (no active control with optical sensors) of a representative sensor system for propulsion and flight control. The optical sensor systems are to be designed to fit alongside the bill-of-materials sensors for comparison. The sensors are to be connected to electrooptic architecture cards which will contain the optical sources and detectors to recover and process the modulated optical signals. The FOCSI program is to collect data on the behavior of passive optical sensor systems in a flight environment and provide valuable information on installation amd maintenance problems for this technology, as well as component survivability (light sources, connectors, optical fibers, etc.).

  15. Advancing Coordination Between DRM and CCA in Integrated Flood Risk Management

    DEFF Research Database (Denmark)

    Flood hazards in coastal regions induce risks toward lives, property, economy and the environment. In need of sustainable and holistic actions to reduce risks, these should include innovative Disaster Risk Management (DRM) and Climate Change Adaptation (CCA) measures. While differing on important...... parameters such as political commitment, awareness and uncertainty of the hazard/risk, commonalities between DRM and CCA can also be identified that affect human settlement, institutional adaptation, and the economy. This supports coordination of mitigation and adaptation measures to create resilience...... and sustainable solutions that take into account present and future outcomes. Adaptation must be integrated in existing policy making and be a planning process priority to become effective, however. In relation to coastal hazards in Denmark, deficits are identified in how DRM is brought into effect, e.g. though...

  16. An Advanced Data Warehouse for Integrating Large Sets of GPS Data

    DEFF Research Database (Denmark)

    Andersen, Ove; Krogh, Benjamin Bjerre; Thomsen, Christian

    2014-01-01

    GPS data recorded from driving vehicles is available from many sources and is a very good data foundation for answering traffic related queries. However, most approaches so far have not considered combining GPS data from many sources into a single data warehouse. Further, the integration of GPS...... data with fuel consumption data (from the so-called CAN bus in the vehicles) and weather data has not been done. In this paper, we propose a data warehouse design for handling GPS data, fuel consumption data, and weather data. The design is fully implemented in a running system using the Postgre......SQL DBMS. The system has been in production since March 2011 and the main fact table contains today approximately 3.4 billion rows from 16 different data sources. We show that the system can be used for a number of novel traffic related analyses such as relating the fuel consumption of vehicles...

  17. Automated, Miniaturized and Integrated Quality Control-on-Chip (QC-on-a-Chip) for Advanced Cell Therapy Applications

    Science.gov (United States)

    Wartmann, David; Rothbauer, Mario; Kuten, Olga; Barresi, Caterina; Visus, Carmen; Felzmann, Thomas; Ertl, Peter

    2015-09-01

    The combination of microfabrication-based technologies with cell biology has laid the foundation for the development of advanced in vitro diagnostic systems capable of evaluating cell cultures under defined, reproducible and standardizable measurement conditions. In the present review we describe recent lab-on-a-chip developments for cell analysis and how these methodologies could improve standard quality control in the field of manufacturing cell-based vaccines for clinical purposes. We highlight in particular the regulatory requirements for advanced cell therapy applications using as an example dendritic cell-based cancer vaccines to describe the tangible advantages of microfluidic devices that overcome most of the challenges associated with automation, miniaturization and integration of cell-based assays. As its main advantage lab-on-a-chip technology allows for precise regulation of culturing conditions, while simultaneously monitoring cell relevant parameters using embedded sensory systems. State-of-the-art lab-on-a-chip platforms for in vitro assessment of cell cultures and their potential future applications for cell therapies and cancer immunotherapy are discussed in the present review.

  18. Automated, Miniaturized and Integrated Quality Control-on-Chip (QC-on-a-Chip for Advanced Cell Therapy Applications

    Directory of Open Access Journals (Sweden)

    David eWartmann

    2015-09-01

    Full Text Available The combination of microfabrication-based technologies with cell biology has laid the foundation for the development of advanced in vitro diagnostic systems capable of evaluating cell cultures under defined, reproducible and standardizable measurement conditions. In the present review we describe recent lab-on-a-chip developments for cell analysis and how these methodologies could improve standard quality control in the field of manufacturing cell-based vaccines for clinical purposes. We highlight in particular the regulatory requirements for advanced cell therapy applications using as an example dendritic cell-based cancer vaccines to describe the tangible advantages of microfluidic devices that overcome most of the challenges associated with automation, miniaturization and integration of cell-based assays. As its main advantage lab-on-a-chip technology allows for precise regulation of culturing conditions, while simultaneously monitoring cell relevant parameters using embedded sensory systems. State-of-the-art lab-on-a-chip platforms for in vitro assessment of cell cultures and their potential future applications for cell therapies and cancer immunotherapy are discussed in the present review.

  19. Integrated methodological frameworks for modelling agent-based advanced supply chain planning systems: A systematic literature review

    Directory of Open Access Journals (Sweden)

    Luis Antonio Santa-Eulalia

    2011-12-01

    Full Text Available Purpose: The objective of this paper is to provide a systematic literature review of recent developments in methodological frameworks for the modelling and simulation of agent-based advanced supply chain planning systems.Design/methodology/approach: A systematic literature review is provided to identify, select and make an analysis and a critical summary of all suitable studies in the area. It is organized into two blocks: the first one covers agent-based supply chain planning systems in general terms, while the second one specializes the previous search to identify those works explicitly containing methodological aspects.Findings: Among sixty suitable manuscripts identified in the primary literature search, only seven explicitly considered the methodological aspects. In addition, we noted that, in general, the notion of advanced supply chain planning is not considered unambiguously, that the social and individual aspects of the agent society are not taken into account in a clear manner in several studies and that a significant part of the works are of a theoretical nature, with few real-scale industrial applications. An integrated framework covering all phases of the modelling and simulation process is still lacking in the literature visited.Research limitations/implications: The main research limitations are related to the period covered (last four years, the selected scientific databases, the selected language (i.e. English and the use of only one assessment framework for the descriptive evaluation part.Practical implications: The identification of recent works in the domain and discussion concerning their limitations can help pave the way for new and innovative researches towards a complete methodological framework for agent-based advanced supply chain planning systems.Originality/value: As there are no recent state-of-the-art reviews in the domain of methodological frameworks for agent-based supply chain planning, this paper contributes to

  20. Integration and Exploitation of Advanced Visualization and Data Technologies to Teach STEM Subjects

    Science.gov (United States)

    Brandon, M. A.; Garrow, K. H.

    2014-12-01

    We live in an age where the volume of content available online to the general public is staggering. Integration of data from new technologies gives us amazing educational opportunities when appropriate narratives are provided. We prepared a distance learning credit bearing module that showcased many currently available data sets and state of the art technologies. It has been completed by many thousands of students with good feedback. Module highlights were the wide ranging and varied online activities which taught a wide range of STEM content. For example: it is well known that on Captain Scott's Terra Nova Expedition 1910-13, three researchers completed the "the worst journey in the world" to study emperor penguins. Using their primary records and clips from location filmed television documentaries we can tell their story and the reasons why it was important. However using state of the art content we can go much further. Using satellite data students can trace the path the researchers took and observe the penguin colony that they studied. Linking to modern Open Access literature students learn how they can estimate the numbers of animals in this and similar locations. Then by linking to freely available data from Antarctic Automatic Weather Stations students can learn quantitatively about the climatic conditions the animals are enduring in real time. They can then download and compare this with the regional climatic record to see if their observations are what could be expected. By considering the environment the penguins live in students can be taught about the evolutionary and behavioural adaptations the animals have undergone to survive. In this one activity we can teach a wide range of key learning points in an engaging and coherent way. It opened some students' eyes to the range of possibilities available to learn about our, and other planets. The addition and integration of new state of the art techniques and data sets only increases the opportunities to

  1. Gas-phase advanced oxidation as an integrated air pollution control technique

    Directory of Open Access Journals (Sweden)

    Getachew A. Adnew

    2016-03-01

    Full Text Available Gas-phase advanced oxidation (GPAO is an emerging air cleaning technology based on the natural self-cleaning processes that occur in the Earth’s atmosphere. The technology uses ozone, UV-C lamps and water vapor to generate gas-phase hydroxyl radicals that initiate oxidation of a wide range of pollutants. In this study four types of GPAO systems are presented: a laboratory scale prototype, a shipping container prototype, a modular prototype, and commercial scale GPAO installations. The GPAO systems treat volatile organic compounds, reduced sulfur compounds, amines, ozone, nitrogen oxides, particles and odor. While the method covers a wide range of pollutants, effective treatment becomes difficult when temperature is outside the range of 0 to 80 °C, for anoxic gas streams and for pollution loads exceeding ca. 1000 ppm. Air residence time in the system and the rate of reaction of a given pollutant with hydroxyl radicals determine the removal efficiency of GPAO. For gas phase compounds and odors including VOCs (e.g. C6H6 and C3H8 and reduced sulfur compounds (e.g. H2S and CH3SH, removal efficiencies exceed 80%. The method is energy efficient relative to many established technologies and is applicable to pollutants emitted from diverse sources including food processing, foundries, water treatment, biofuel generation, and petrochemical industries.

  2. Advancing biopharmaceutical process development by system-level data analysis and integration of omics data.

    Science.gov (United States)

    Schaub, Jochen; Clemens, Christoph; Kaufmann, Hitto; Schulz, Torsten W

    2012-01-01

    Development of efficient bioprocesses is essential for cost-effective manufacturing of recombinant therapeutic proteins. To achieve further process improvement and process rationalization comprehensive data analysis of both process data and phenotypic cell-level data is essential. Here, we present a framework for advanced bioprocess data analysis consisting of multivariate data analysis (MVDA), metabolic flux analysis (MFA), and pathway analysis for mapping of large-scale gene expression data sets. This data analysis platform was applied in a process development project with an IgG-producing Chinese hamster ovary (CHO) cell line in which the maximal product titer could be increased from about 5 to 8 g/L.Principal component analysis (PCA), k-means clustering, and partial least-squares (PLS) models were applied to analyze the macroscopic bioprocess data. MFA and gene expression analysis revealed intracellular information on the characteristics of high-performance cell cultivations. By MVDA, for example, correlations between several essential amino acids and the product concentration were observed. Also, a grouping into rather cell specific productivity-driven and process control-driven processes could be unraveled. By MFA, phenotypic characteristics in glycolysis, glutaminolysis, pentose phosphate pathway, citrate cycle, coupling of amino acid metabolism to citrate cycle, and in the energy yield could be identified. By gene expression analysis 247 deregulated metabolic genes were identified which are involved, inter alia, in amino acid metabolism, transport, and protein synthesis.

  3. Developing a common framework for integrated solid waste management advances in Managua, Nicaragua.

    Science.gov (United States)

    Olley, Jane E; IJgosse, Jeroen; Rudin, Victoria; Alabaster, Graham

    2014-09-01

    This article describes the municipal solid waste management system in Managua, Nicaragua. It updates an initial profile developed by the authors for the 2010 UN-HABITAT publication Solid Waste Management in the World's Cities and applies the methodology developed in that publication. In recent years, the municipality of Managua has been the beneficiary of a range of international cooperation projects aimed at improving municipal solid waste management in the city. The article describes how these technical assistance and infrastructure investments have changed the municipal solid waste management panorama in the city and analyses the sustainability of these changes. The article concludes that by working closely with the municipal government, the UN-HABITAT project Strengthening Capacities for Solid Waste Management in Managua was able to unite these separate efforts and situate them within a strategic framework to guide the evolution of the municipal solid waste management system in the forthcoming years. The creation of this multi-stakeholder platform allowed for the implementation of joint activities and ensured coherence in the products generated by the different projects. This approach could be replicated in other cities and in other sectors with similar effect. Developing a long term vision was essential for the advancement of municipal solid waste management in the city. Nevertheless, plan implementation may still be undermined by the pressures of the short term municipal administrative government, which emphasize operational over strategic investment.

  4. Solvent selection methodology for pharmaceutical processes: Solvent swap

    DEFF Research Database (Denmark)

    Papadakis, Emmanouil; Kumar Tula, Anjan; Gani, Rafiqul

    2016-01-01

    A method for the selection of appropriate solvents for the solvent swap task in pharmaceutical processes has been developed. This solvent swap method is based on the solvent selection method of Gani et al. (2006) and considers additional selection criteria such as boiling point difference, volati...

  5. Effect of integrated Chinese medical treatment on the survival time of patients with advanced non-small-cell lung cancer: a clinical study

    Institute of Scientific and Technical Information of China (English)

    刘苓霜

    2014-01-01

    Objective To observe clinical effect of integrated Chinese medical(CM)treatment(as maintenance therapy)on the progression-free survival(PFS)and overall survival(OS)in patients with advanced non-small-cell lung cancer(NSCLC)after first-line chemotherapy.Methods The study was a prospective,randomized,controlled clinical trial.Totally 69 non-progressive advanced NSCLC patients treated with first-line chemotherapy were

  6. Integrated Graphics Operations and Analysis Lab Development of Advanced Computer Graphics Algorithms

    Science.gov (United States)

    Wheaton, Ira M.

    2011-01-01

    The focus of this project is to aid the IGOAL in researching and implementing algorithms for advanced computer graphics. First, this project focused on porting the current International Space Station (ISS) Xbox experience to the web. Previously, the ISS interior fly-around education and outreach experience only ran on an Xbox 360. One of the desires was to take this experience and make it into something that can be put on NASA s educational site for anyone to be able to access. The current code works in the Unity game engine which does have cross platform capability but is not 100% compatible. The tasks for an intern to complete this portion consisted of gaining familiarity with Unity and the current ISS Xbox code, porting the Xbox code to the web as is, and modifying the code to work well as a web application. In addition, a procedurally generated cloud algorithm will be developed. Currently, the clouds used in AGEA animations and the Xbox experiences are a texture map. The desire is to create a procedurally generated cloud algorithm to provide dynamically generated clouds for both AGEA animations and the Xbox experiences. This task consists of gaining familiarity with AGEA and the plug-in interface, developing the algorithm, creating an AGEA plug-in to implement the algorithm inside AGEA, and creating a Unity script to implement the algorithm for the Xbox. This portion of the project was unable to be completed in the time frame of the internship; however, the IGOAL will continue to work on it in the future.

  7. Integrating organic micropollutant removal into tertiary filtration: Combining PAC adsorption with advanced phosphorus removal.

    Science.gov (United States)

    Altmann, Johannes; Sperlich, Alexander; Jekel, Martin

    2015-11-01

    Direct addition of powdered activated carbon (PAC) to a deep-bed filter was investigated at pilot-scale as a single advanced treatment stage for simultaneous removal of organic micropollutants (OMPs) and phosphorus from secondary effluent. PAC doses of 10-50 mg/L were assessed with regard to their impacts on filter performance and removal of 15 selected OMPs over a period of 18 months. The PAC was effectively retained by the filter and had no negative effect on filter head loss. Filter runtime until particle breakthrough depended mainly on coagulant dose and did not decrease significantly due to the additional PAC load. Removal of suspended solids and phosphorus by coagulation was effective independent of the PAC dose. A PAC dose of 35 mg/L PAC was suitable to remove well-adsorbing OMPs (e.g. carbamazepine, diclofenac) by >80% and medium adsorbing OMPs (e.g. primidone, sulfamethoxazole) by 50-80%. Median removals were 50-80% for well-adsorbing and 30-50% for medium adsorbing OMPs with 20 mg/L PAC. Abatement of all OMPs was low (PAC, possibly because of the high effluent organic matter content (median dissolved organic carbon (DOC) concentrations of 11.2 mg/L). In addition to adsorptive removal, relevant concentration decreases of certain OMPs (e.g. 4-formylaminoantipyrine) were attributed to biological transformation in the filter. Adsorption onto accumulating PAC in the top layer of the filter bed led to improved OMP adsorption with increasing filter runtime. The comparison of OMP removal in the pilot filter with laboratory adsorption tests demonstrates that batch test results can be applied to estimate adsorptive OMP removal in real applications.

  8. Noble gas and hydrocarbon tracers in multiphase unconventional hydrocarbon systems: Toward integrated advanced reservoir simulators

    Science.gov (United States)

    Darrah, T.; Moortgat, J.; Poreda, R. J.; Muehlenbachs, K.; Whyte, C. J.

    2015-12-01

    Although hydrocarbon production from unconventional energy resources has increased dramatically in the last decade, total unconventional oil and gas recovery from black shales is still less than 25% and 9% of the totals in place, respectively. Further, the majority of increased hydrocarbon production results from increasing the lengths of laterals, the number of hydraulic fracturing stages, and the volume of consumptive water usage. These strategies all reduce the economic efficiency of hydrocarbon extraction. The poor recovery statistics result from an insufficient understanding of some of the key physical processes in complex, organic-rich, low porosity formations (e.g., phase behavior, fluid-rock interactions, and flow mechanisms at nano-scale confinement and the role of natural fractures and faults as conduits for flow). Noble gases and other hydrocarbon tracers are capably of recording subsurface fluid-rock interactions on a variety of geological scales (micro-, meso-, to macro-scale) and provide analogs for the movement of hydrocarbons in the subsurface. As such geochemical data enrich the input for the numerical modeling of multi-phase (e.g., oil, gas, and brine) fluid flow in highly heterogeneous, low permeability formations Herein we will present a combination of noble gas (He, Ne, Ar, Kr, and Xe abundances and isotope ratios) and molecular and isotopic hydrocarbon data from a geographically and geologically diverse set of unconventional hydrocarbon reservoirs in North America. Specifically, we will include data from the Marcellus, Utica, Barnett, Eagle Ford, formations and the Illinois basin. Our presentation will include geochemical and geological interpretation and our perspective on the first steps toward building an advanced reservoir simulator for tracer transport in multicomponent multiphase compositional flow (presented separately, in Moortgat et al., 2015).

  9. Advanced Recovery and Integrated Extraction System (ARIES): The United State's demonstration line for pit disassembly and conversion

    Energy Technology Data Exchange (ETDEWEB)

    Nelson, Timothy O.

    1998-03-01

    The Advanced Recovery and Integrated Extraction System (ARIES) is a pit disassembly and conversion demonstration line at Los Alamos National Laboratory's plutonium facility. Pits are the core of a nuclear weapon that contains fissile material. With the end of the cold war, the United States began a program to dispose of the fissile material contained in surplus nuclear weapons. In January of 1997, the Department of Energy's Office of Fissile Material Disposition issued a Record of Decision (ROD) on the disposition of surplus plutonium. This decision contained a hybrid option for disposition of the plutonium, immobilization and mixed oxide fuel. ARIES is the cornerstone of the United States plutonium disposition program that supplies the pit demonstration plutonium feed material for either of these disposition pathways. Additionally, information from this demonstration is being used to design the United States Pit Disassembly and Conversion Facility. AH of the ARIES technologies were recently developed and incorporate waste minimization. The technologies include pit bisection, hydride/dehydride, metal to oxide conversion process, packaging, and nondestructive assay (NDA). The current schedule for the ARIES integrated Demonstration will begin in the Spring of 1998. The ARIES project involves a number of DOE sites including Los Alamos National Laboratory as the lead laboratory, Lawrence Livermore National Laboratory (LLNL), and Sandia National Laboratories. Moreover, the ARIES team is heavily involved in working with Russia in their pit disassembly and conversion activities.

  10. Integrating Compassionate, Collaborative Care (the "Triple C") Into Health Professional Education to Advance the Triple Aim of Health Care.

    Science.gov (United States)

    Lown, Beth A; McIntosh, Sharrie; Gaines, Martha E; McGuinn, Kathy; Hatem, David S

    2016-03-01

    Empathy and compassion provide an important foundation for effective collaboration in health care. Compassion (the recognition of and response to the distress and suffering of others) should be consistently offered by health care professionals to patients, families, staff, and one another. However, compassion without collaboration may result in uncoordinated care, while collaboration without compassion may result in technically correct but depersonalized care that fails to meet the unique emotional and psychosocial needs of all involved. Providing compassionate, collaborative care (CCC) is critical to achieving the "triple aim" of improving patients' health and experiences of care while reducing costs. Yet, values and skills related to CCC (or the "Triple C") are not routinely taught, modeled, and assessed across the continuum of learning and practice. To change this paradigm, an interprofessional group of experts recently recommended approaches and a framework for integrating CCC into health professional education and postgraduate training as well as clinical care. In this Perspective, the authors describe how the Triple C framework can be integrated and enhance existing competency standards to advance CCC across the learning and practice continuum. They also discuss strategies for partnering with patients and families to improve health professional education and health care design and delivery through quality improvement projects. They emphasize that compassion and collaboration are important sources of professional, patient, and family satisfaction as well as critical aspects of professionalism and person-centered, relationship-based high-quality care.

  11. Recent advances in marching-on-in-time schemes for solving time domain volume integral equations

    KAUST Repository

    Sayed, Sadeed Bin

    2015-05-16

    Transient electromagnetic field interactions on inhomogeneous penetrable scatterers can be analyzed by solving time domain volume integral equations (TDVIEs). TDVIEs are constructed by setting the summation of the incident and scattered field intensities to the total field intensity on the volumetric support of the scatterer. The unknown can be the field intensity or flux/current density. Representing the total field intensity in terms of the unknown using the relevant constitutive relation and the scattered field intensity in terms of the spatiotemporal convolution of the unknown with the Green function yield the final form of the TDVIE. The unknown is expanded in terms of local spatial and temporal basis functions. Inserting this expansion into the TDVIE and testing the resulting equation at discrete times yield a system of equations that is solved by the marching on-in-time (MOT) scheme. At each time step, a smaller system of equations, termed MOT system is solved for the coefficients of the expansion. The right-hand side of this system consists of the tested incident field and discretized spatio-temporal convolution of the unknown samples computed at the previous time steps with the Green function.

  12. Raising Expectations for U.S. Youth with Disabilities: Federal Disability Policy Advances Integrated Employment

    Directory of Open Access Journals (Sweden)

    Jeanne Novak

    2015-03-01

    Full Text Available While conversations around the inclusion of individuals with disabilities often focus on the educational rights and needs of children with disabilities during their school years, there is a growing recognition that the period of transition from secondary school to adult roles is a critical time in the lives of individuals with disabilities. For young people, gaining meaning ful employment in a typical community job is an important step towards realising full community membership. The present article examines how contemporary U.S. federal disability policy has heightened expectations that youth with disabilities – including those with significant disabilities – can and should be prepared to work in integrated workplaces. The article begins with a consideration of how evolving assumptions about the nature of disability and the employment potential of individuals with significant disabilities have influenced the development of federal disability policy in the U.S. This is followed by an overview of key legislative and policy developments in the areas of civil rights and workforce development that have the potential to dramatically impact the employment outlook for young people with disabilities. The article concludes with a discussion of challenges in translating the legislative intent of federal disability policy into noticeable improvements in employment outcomes, along with recommendations for aligning legislation, funding priorities and service delivery systems to achieve policy goals.

  13. New politics, an opportunity for maternal health advancement in eastern myanmar: an integrative review.

    Science.gov (United States)

    Loyer, Adam B; Ali, Mohammed; Loyer, Diana

    2014-09-01

    Myanmar (formerly Burma) is a southeast Asian country, with a long history of military dictatorship, human rights violations, and poor health indicators. The health situation is particularly dire among pregnant women in the ethnic minorities of the eastern provinces (Kachin, Shan, Mon, Karen and Karenni regions). This integrative review investigates the current status of maternal mortality in eastern Myanmar in the context of armed conflict between various separatist groups and the military regime. The review examines the underlying factors contributing to high maternal mortality in eastern Myanmar and assesses gaps in the existing research, suggesting areas for further research and policy response. Uncovered were a number of underlying factors uniquely contributing to maternal mortality in eastern Myanmar. These could be grouped into the following analytical themes: ongoing conflict, health system deficits, and political and socioeconomic influences. Abortion was interestingly not identified as an important contributor to maternal mortality. Recent political liberalization may provide space to act upon identified roles and opportunities for the Myanmar Government, the international community, and non-governmental organizations (NGOs) in a manner that positively impacts on maternal healthcare in the eastern regions of Myanmar. This review makes a number of recommendations to this effect.

  14. Integration

    DEFF Research Database (Denmark)

    Emerek, Ruth

    2004-01-01

    Bidraget diskuterer de forskellige intergrationsopfattelse i Danmark - og hvad der kan forstås ved vellykket integration......Bidraget diskuterer de forskellige intergrationsopfattelse i Danmark - og hvad der kan forstås ved vellykket integration...

  15. Gravity Spy: integrating advanced LIGO detector characterization, machine learning, and citizen science

    Science.gov (United States)

    Zevin, M.; Coughlin, S.; Bahaadini, S.; Besler, E.; Rohani, N.; Allen, S.; Cabero, M.; Crowston, K.; Katsaggelos, A. K.; Larson, S. L.; Lee, T. K.; Lintott, C.; Littenberg, T. B.; Lundgren, A.; Østerlund, C.; Smith, J. R.; Trouille, L.; Kalogera, V.

    2017-03-01

    With the first direct detection of gravitational waves, the advanced laser interferometer gravitational-wave observatory (LIGO) has initiated a new field of astronomy by providing an alternative means of sensing the universe. The extreme sensitivity required to make such detections is achieved through exquisite isolation of all sensitive components of LIGO from non-gravitational-wave disturbances. Nonetheless, LIGO is still susceptible to a variety of instrumental and environmental sources of noise that contaminate the data. Of particular concern are noise features known as glitches, which are transient and non-Gaussian in their nature, and occur at a high enough rate so that accidental coincidence between the two LIGO detectors is non-negligible. Glitches come in a wide range of time-frequency-amplitude morphologies, with new morphologies appearing as the detector evolves. Since they can obscure or mimic true gravitational-wave signals, a robust characterization of glitches is paramount in the effort to achieve the gravitational-wave detection rates that are predicted by the design sensitivity of LIGO. This proves a daunting task for members of the LIGO Scientific Collaboration alone due to the sheer amount of data. In this paper we describe an innovative project that combines crowdsourcing with machine learning to aid in the challenging task of categorizing all of the glitches recorded by the LIGO detectors. Through the Zooniverse platform, we engage and recruit volunteers from the public to categorize images of time-frequency representations of glitches into pre-identified morphological classes and to discover new classes that appear as the detectors evolve. In addition, machine learning algorithms are used to categorize images after being trained on human-classified examples of the morphological classes. Leveraging the strengths of both classification methods, we create a combined method with the aim of improving the efficiency and accuracy of each individual

  16. Purex process solvent: literature review

    Energy Technology Data Exchange (ETDEWEB)

    Geier, R.G.

    1979-10-01

    This document summarizes the data on Purex process solvent presently published in a variety of sources. Extracts from these various sources are presented herein and contain the work done, the salient results obtained, and the original, unaltered conclusions of the author of each paper. Three major areas are addressed: solvent stability, solvent quality testing, and solvent treatment processes. 34 references, 44 tables.

  17. Complete pathological responses in locally advanced rectal cancer after preoperative IMRT and integrated-boost chemoradiation

    Energy Technology Data Exchange (ETDEWEB)

    Hernando-Requejo, Ovidio [Hospital Universitario Sanchinarro, Department of Radiation Oncology, Madrid (Spain); Hospital Universitario Sanchinarro, CEU San Pablo University, Madrid (Spain); HM Universitario Sanchinarro, Centro Integral Oncologico Clara Campal, Madrid (Spain); Lopez, Mercedes; Rodriguez, Almudena; Ciervide, Raquel; Valero, Jeannette; Sanchez, Emilio; Garcia-Aranda, Mariola; Potdevin, Guillermo [Hospital Universitario Sanchinarro, Department of Radiation Oncology, Madrid (Spain); Cubillo, Antonio; Rodriguez, Jesus [Hospital Universitario Sanchinarro, Department of Medical Oncology, Madrid (Spain); Hospital Universitario Sanchinarro, CEU San Pablo University, Madrid (Spain); Rubio, Carmen [Hospital Universitario Sanchinarro, Department of Radiation Oncology, Madrid (Spain); Hospital Universitario Sanchinarro, CEU San Pablo University, Madrid (Spain)

    2014-06-15

    To analyze the efficacy and safety of a new preoperative intensity-modulated radiotherapy (IMRT) and integrated-boost chemoradiation scheme. In all, 74 patients were treated with IMRT and concurrent standard dose capecitabine. The dose of the planning target volume (PTV) encompassing the tumor, mesorectum, and pelvic lymph nodes was 46 Gy in 23 fractions; the boost PTV, at a dose of 57.5 Gy in 23 fractions, included the macroscopic primary tumor and pathological lymph nodes. The patients underwent surgery 6-8 weeks after chemoradiation. The complete treatment data of 72 patients were analyzed. Tumor downstaging was achieved in 55 patients (76.38 %) and node downstaging in 34 (47.2 %). In 22 patients (30.6 %), there was complete pathological response (ypCR). The circumferential resection margin was free of tumor in 70 patients (97.2 %). The 3-year estimated overall survival and disease-free survival rates were 95.4 and 85.9 % respectively, and no local relapse was found; however, ten patients (13.8 %) developed distant metastases. High pathologic tumor (pT) downstaging was shown as a favorable prognostic factor for disease-free survival. No grade 4 acute radiotherapy-related toxicity was found. The IMRT and integrated-boost chemoradiation scheme offered higher rates of ypCR and pT downstaging, without a significant increase in toxicity. The circumferential margins were free of tumors in the majority of patients. Primary tumor regression was associated with better disease-free survival. (orig.) [German] Analyse von Wirksamkeit und Sicherheit eines neuen praeoperativen intensitaetsmodulierten Bestrahlungsschemas (IMRT) mit integriertem Boost. Insgesamt 74 Patienten wurden simultan mit IMRT und Capecitabin (Standarddosis) behandelt. Die Dosis des Planungszielvolumens (PTV) umfasste den Tumor, das Mesorektum sowie die Beckenlymphknoten und betrug 46 Gy in 23 Fraktionen. Das Boost-PTV betrug 57,5 Gy in 23 Fraktionen und umfasste den makroskopischen Primaertumor und die

  18. Development of ITM oxygen technology for integration in IGCC and other advanced power generation

    Energy Technology Data Exchange (ETDEWEB)

    Armstrong, Phillip A. [Air Products And Chemicals, Inc., Allentown, PA (United States)

    2015-03-31

    Ion Transport Membrane (ITM) technology is based on the oxygen-ion-conducting properties of certain mixed-metal oxide ceramic materials that can separate oxygen from an oxygen-containing gas, such as air, under a suitable driving force. The “ITM Oxygen” air separation system that results from the use of such ceramic membranes produces a hot, pure oxygen stream and a hot, pressurized, oxygen-depleted stream from which significant amounts of energy can be extracted. Accordingly, the technology integrates well with other high-temperature processes, including power generation. Air Products and Chemicals, Inc., the Recipient, in conjunction with a dozen subcontractors, developed ITM Oxygen technology under this five-phase Cooperative Agreement from the laboratory bench scale to implementation in a pilot plant capable of producing power and 100 tons per day (TPD) of purified oxygen. A commercial-scale membrane module manufacturing facility (the “CerFab”), sized to support a conceptual 2000 TPD ITM Oxygen Development Facility (ODF), was also established and operated under this Agreement. In the course of this work, the team developed prototype ceramic production processes and a robust planar ceramic membrane architecture based on a novel ceramic compound capable of high oxygen fluxes. The concept and feasibility of the technology was thoroughly established through laboratory pilot-scale operations testing commercial-scale membrane modules run under industrial operating conditions with compelling lifetime and reliability performance that supported further scale-up. Auxiliary systems, including contaminant mitigation, process controls, heat exchange, turbo-machinery, combustion, and membrane pressure vessels were extensively investigated and developed. The Recipient and subcontractors developed efficient process cycles that co-produce oxygen and power based on compact, low-cost ITMs. Process economics assessments show significant benefits relative to state

  19. RENEWABLE ENERGY, A KEY TO INTEGRATING COMPETITIVE POLICIES WITH ADVANCED ENVIRONMENT PROTECTION STRATEGIES

    Directory of Open Access Journals (Sweden)

    Cinade Lucian Ovidiu

    2011-12-01

    Full Text Available Development of competitive policies and improvement of environment protection strategies are two basic trends of the development of the European Unique Market. Energy, also known as 'industry bread', is basic product and strategic resource, where energy industry plays an obvious role in the economic and social development of any community. Traditional energy production is marred by three major drawbacks: it generates negative externalities by polluting; it is totally in the hands of the producers; hence, prices rise at their will, of fossil fuels such as oil and gas. Present study focuses on electric energy industry, yet bearing over the whole length of the chain producer-to-end-consumer, thus revealed as particularly complex. The question is do alternative energy sources meet the prerequisite of market being competitive meanwhile environment protection being highly observed. We identify limits in point, of the energy market; effects of market liberalization; entry barriers; interchangeability level of energy sources; active forces on the energy market. Competitive rivalry has been expressed as per market micro-economic analysis, based on Michael Porter's 5-forces model. It will thus be noticed that, morphologically, competition evolution depends firstly on the market type. For the time being, the consumer on the energy market stays captive, for various reasons such as: legislation; limits of energy transfer infrastructure; scarcity of resources; resources availability imbalance; no integrative strategy available, of renewable energy resources usage. Energy availability is vital for human society to function. Comparative advantages of renewable energy resources are twofold, as manifested: in terms of economics, i.e. improving competition by substitute products entered at the same time as new producers enter market; and in terms of ecology, by reducing CO2 emissions. As to energy production technology and transfer, the complementary nature will

  20. Advances in EBSD and EBSD/EDS integration for the characterization of mineralogical samples

    Science.gov (United States)

    Palasse, L.; Goran, D.; Schwager, T.

    2013-12-01

    (<10 nm) of this technique compared to conventional EBSD. EBSD phase map of an oxide gabbro collected by the Integrated Ocean Drilling Program Expedition 304/305, U1309D. phases: clinopyroxene, clinohypersthene, magnetite, ilmenite, tremolite, plagioclase, quartz, pyrrhotite, apatite, clinochlore. Sample courtesy: Dr. Angela Halfpenny, CSIRO Perth, Australia.

  1. Photonics-on-a-chip: recent advances in integrated waveguides as enabling detection elements for real-world, lab-on-a-chip biosensing applications.

    Science.gov (United States)

    Washburn, Adam L; Bailey, Ryan C

    2011-01-21

    By leveraging advances in semiconductor microfabrication technologies, chip-integrated optical biosensors are poised to make an impact as scalable and multiplexable bioanalytical measurement tools for lab-on-a-chip applications. In particular, waveguide-based optical sensing technology appears to be exceptionally amenable to chip integration and miniaturization, and, as a result, the recent literature is replete with examples of chip-integrated waveguide sensing platforms developed to address a wide range of contemporary analytical challenges. As an overview of the most recent advances within this dynamic field, this review highlights work from the last 2-3 years in the areas of grating-coupled, interferometric, photonic crystal, and microresonator waveguide sensors. With a focus towards device integration, particular emphasis is placed on demonstrations of biosensing using these technologies within microfluidically controlled environments. In addition, examples of multiplexed detection and sensing within complex matrices--important features for real-world applicability--are given special attention.

  2. Developing a Patient Care Co-ordination Centre in Trafford, England: lessons from the International Foundation for Integrated Care (IFIC/Advancing Quality Alliance integrated care fellowship experience

    Directory of Open Access Journals (Sweden)

    Michael Gregory

    2015-05-01

    Full Text Available The NHS and Social Care in England are facing one of the biggest financial challenges for a generation. Commissioners and providers need to work on collaborative schemes to manage the increasing demand on health and social care within a period of financial constraint. Different forms of care co-ordination have been developed at different levels across the world.In the north-west of England, the Trafford health and social care economy have been working through a competitive dialogue process with industry to develop an innovative and dynamic solution to deliver seamless co-ordination for all patients and service users. The strategy is to develop a new Patient Care Co-ordination Centre, which will be responsible for the delivery of co-ordinated, quality care. The Patient Care Co-ordination Centre will work at clinical, service, functional and community levels across multiple providers covering risk stratification, preventative, elective and unscheduled care.I am the clinical lead for the Patient Care Co-ordination Centre and during my year as an Advancing Quality Alliance Integrated Care Fellow, I have had the opportunity to study examples of care coordination from UK and international sites. The learning from these visits has been assimilated into the design process of the Patient Care Co-ordination Centre.

  3. Advanced variable speed air source integrated heat pump (AS-IHP) development - CRADA final report

    Energy Technology Data Exchange (ETDEWEB)

    Baxter, Van D. [Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States); Rice, C. Keith [Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States); Munk, Jeffrey D. [Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States); Ally, Moonis Raza [Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States); Shen, Bo [Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

    2015-09-30

    Between August 2011 and September 2015, Oak Ridge National Laboratory (ORNL) and Nordyne, LLC (now Nortek Global HVAC LLC, NGHVAC) engaged in a Cooperative Research and Development Agreement (CRADA) to develop an air-source integrated heat pump (AS-IHP) system for the US residential market. Two generations of laboratory prototype systems were designed, fabricated, and lab-tested during 2011-2013. Performance maps for the system were developed using the latest research version of the DOE/ORNL Heat Pump Design Model, or HPDM, (Rice 1991; Rice and Jackson 2005; Shen et al 2012) as calibrated against the lab test data. These maps were the input to the TRNSYS (SOLAR Energy Laboratory, et al, 2010) system to predict annual performance relative to a baseline suite of equipment meeting minimum efficiency standards in effect in 2006 (combination of 13 SEER air-source heat pump (ASHP) and resistance water heater with Energy Factor (EF) of 0.9). Predicted total annual energy savings, while providing space conditioning and water heating for a tight, well insulated 2600 ft2 (242 m2) house at 5 U.S. locations, ranged from 46 to 61%, averaging 52%, relative to the baseline system (lowest savings at the cold-climate Chicago location). Predicted energy use for water heating was reduced 62 to 76% relative to resistance WH. Based on these lab prototype test and analyses results a field test prototype was designed and fabricated by NGHVAC. The unit was installed in a 2400 ft2 (223 m2) research house in Knoxville, TN and field tested from May 2014 to April 2015. Based on the demonstrated field performance of the AS-IHP prototype and estimated performance of a baseline system operating under the same loads and weather conditions, it was estimated that the prototype would achieve ~40% energy savings relative to the minimum efficiency suite. The estimated WH savings were >60% and SC mode savings were >50%. But estimated SH savings were only about 20%. It is believed that had the test

  4. Soil Contamination, Advanced integrated characterisation and time-lapse Monitoring, SoilCAM project highlights

    Science.gov (United States)

    French, H. K.; Van Der Zee, S. E.; Wehrer, M.; Godio, A.; Pedersen, L. B.; Tsocano, G.

    2013-12-01

    measurements indicate where the remaining crude oil can be found. Water samples from multilevel samplers reveal crude oil present in emulsion in the zone of groundwater fluctuations, highlighting the importance of colloidal transport. Modelling of multiphase flow of the fluctuating groundwater level explains the lack of horizontal displacement of the plume in the area. Geochemistry of the groundwater clearly indicates degradation of hydrocarbons under iron- and sulphate reducing conditions, but changes were too slow to be mapped by time-lapse geophysical measurements during the project period. MODFLOW was used to simulate the regional groundwater flow and transport in the area. Highlights of the results from both test sites will be presented as an integrated overview. Snow removal at Oslo airport

  5. Single Stage Contactor Testing Of The Next Generation Solvent Blend

    Energy Technology Data Exchange (ETDEWEB)

    Herman, D. T.; Peters, T. B.; Duignan, M. R.; Williams, M. R.; Poirier, M. R.; Brass, E. A.; Garrison, A. G.; Ketusky, E. T.

    2014-01-06

    The Modular Caustic Side Solvent Extraction (CSSX) Unit (MCU) facility at the Savannah River Site (SRS) is actively pursuing the transition from the current BOBCalixC6 based solvent to the Next Generation Solvent (NGS)-MCU solvent to increase the cesium decontamination factor. To support this integration of NGS into the MCU facility the Savannah River National Laboratory (SRNL) performed testing of a blend of the NGS (MaxCalix based solvent) with the current solvent (BOBCalixC6 based solvent) for the removal of cesium (Cs) from the liquid salt waste stream. This testing utilized a blend of BOBCalixC6 based solvent and the NGS with the new extractant, MaxCalix, as well as a new suppressor, tris(3,7dimethyloctyl) guanidine. Single stage tests were conducted using the full size V-05 and V-10 liquid-to-liquid centrifugal contactors installed at SRNL. These tests were designed to determine the mass transfer and hydraulic characteristics with the NGS solvent blended with the projected heel of the BOBCalixC6 based solvent that will exist in MCU at time of transition. The test program evaluated the amount of organic carryover and the droplet size of the organic carryover phases using several analytical methods. The results indicate that hydraulically, the NGS solvent performed hydraulically similar to the current solvent which was expected. For the organic carryover 93% of the solvent is predicted to be recovered from the stripping operation and 96% from the extraction operation. As for the mass transfer, the NGS solvent significantly improved the cesium DF by at least an order of magnitude when extrapolating the One-stage results to actual Seven-stage extraction operation with a stage efficiency of 95%.

  6. Halogenated solvent remediation

    Science.gov (United States)

    Sorenson, Kent S.

    2004-08-31

    Methods for enhancing bioremediation of ground water contaminated with nonaqueous halogenated solvents are disclosed. A preferred method includes adding a composition to the ground water wherein the composition is an electron donor for microbe-mediated reductive dehalogenation of the halogenated solvents and enhances mass transfer of the halogenated solvents from residual source areas into the aqueous phase of the ground water. Illustrative compositions effective in these methods include surfactants such as C.sub.2 -C.sub.4 carboxylic acids and hydroxy acids, salts thereof, esters of C.sub.2 -C.sub.4 carboxylic acids and hydroxy acids, and mixtures thereof. Especially preferred compositions for use in these methods include lactic acid, salts of lactic acid, such as sodium lactate, lactate esters, and mixtures thereof. The microbes are either indigenous to the ground water, or such microbes can be added to the ground water in addition to the composition.

  7. Solvent System Selection Strategies in Countercurrent Separation

    Science.gov (United States)

    Liu, Yang; Friesen, J. Brent; McAlpine, James B.; Pauli, Guido F.

    2015-01-01

    The majority of applications in countercurrent and centrifugal partition chromatography, collectively known as countercurrent separation, are dedicated to medicinal plant and natural product research. In countercurrent separation, the selection of the appropriate solvent system is of utmost importance as it is the equivalent to the simultaneous choice of column and eluent in liquid chromatography. However, solvent system selection is often laborious, involving extensive partition and/or analytical trials. Therefore, simplified solvent system selection strategies that predict the partition coefficients and, thus, analyte behavior are in high demand and may advance both the science of countercurrent separation and its applications. The last decade of solvent system selection theory and applications are critically reviewed, and strategies are classified according to their data input requirements. This offers the practitioner an up-to-date overview of rationales and methods for choosing an efficient solvent system, provides a perspective regarding their accuracy, reliability, and practicality, and discusses the possibility of combining multiple methods for enhanced prediction power. PMID:26393937

  8. Assessing the performance of an advanced integrated facade by means of simulation: The ACTRESS facade case study

    Directory of Open Access Journals (Sweden)

    Fabio Favoino

    2015-11-01

    Full Text Available The growing demand for both building energy efficiency and indoor environmental comfort is leading to a substantial evolution of the traditional concept of the building envelope. The future building skin is required to be responsive and dynamic, actively regulating the flows of heat, light, air and water from outdoor to indoor and vice versa, in order to effectively respond to ever-changing climatic conditions, occupant comfort and energy efficiency requirements. In the framework of a decade-long research activity on Advanced Integrated Facade, AIF, a new Multifunctional Facade Module called ACTRESS has been conceived: the ACTive, RESponsive and Solar envelope is designedto play different roles through its ability to change its thermo-physical behaviour in order to suit the different environmental conditions. This paper briefly illustrates the ACTRESS MFM concept and its functional strategies, focusing on the simulation and the assessment of the performance of such a dynamic envelope. The numerical study was conducted in order to evaluate the potential energy savings achievable with such a facade and to evaluate different functional strategies and options. The evaluation of the performance in terms of energy savings was done at both component and whole-building level. Moreover this work presents an example of the applicability of Building Performance Simulation tools to the design of an innovative and dynamic facade system, discussing the capability of BPS software in simulating and evaluating the performance of such systems. The results show that the ACTRESS MFM can effectively reduce the total primary energy consumption of an office building up to 55% compared with a reference facade complying with national regulations. On the other hand modelling assumptions and simplifications are needed in order to evaluate the performance of such a system with BPS software, representing a barrier to the design and the adoption of advanced facade systems in

  9. A Capstone Course with a Comprehensive and Integrated Review of the Pharmacy Curriculum and Student Assessment as a Preparation for Advanced Pharmacy Practice Experiences

    OpenAIRE

    Hirsch, Adina C.; Parihar, Harish S.

    2014-01-01

    Objective. To create a capstone course that provides a comprehensive and integrated review of the pharmacy curriculum with a broad range of assessment tools to evaluate student knowledge and skills as a final preparation prior to beginning fourth-year advanced pharmacy practice experiences (APPEs).

  10. Integrating Remote Sensing Data, Hybrid-Cloud Computing, and Event Notifications for Advanced Rapid Imaging & Analysis (Invited)

    Science.gov (United States)

    Hua, H.; Owen, S. E.; Yun, S.; Lundgren, P.; Fielding, E. J.; Agram, P.; Manipon, G.; Stough, T. M.; Simons, M.; Rosen, P. A.; Wilson, B. D.; Poland, M. P.; Cervelli, P. F.; Cruz, J.

    2013-12-01

    Space-based geodetic measurement techniques such as Interferometric Synthetic Aperture Radar (InSAR) and Continuous Global Positioning System (CGPS) are now important elements in our toolset for monitoring earthquake-generating faults, volcanic eruptions, hurricane damage, landslides, reservoir subsidence, and other natural and man-made hazards. Geodetic imaging's unique ability to capture surface deformation with high spatial and temporal resolution has revolutionized both earthquake science and volcanology. Continuous monitoring of surface deformation and surface change before, during, and after natural hazards improves decision-making from better forecasts, increased situational awareness, and more informed recovery. However, analyses of InSAR and GPS data sets are currently handcrafted following events and are not generated rapidly and reliably enough for use in operational response to natural disasters. Additionally, the sheer data volumes needed to handle a continuous stream of InSAR data sets also presents a bottleneck. It has been estimated that continuous processing of InSAR coverage of California alone over 3-years would reach PB-scale data volumes. Our Advanced Rapid Imaging and Analysis for Monitoring Hazards (ARIA-MH) science data system enables both science and decision-making communities to monitor areas of interest with derived geodetic data products via seamless data preparation, processing, discovery, and access. We will present our findings on the use of hybrid-cloud computing to improve the timely processing and delivery of geodetic data products, integrating event notifications from USGS to improve the timely processing for response, as well as providing browse results for quick looks with other tools for integrative analysis.

  11. Challenge problem and milestones for : Nuclear Energy Advanced Modeling and Simulation (NEAMS) waste Integrated Performance and Safety Codes (IPSC).

    Energy Technology Data Exchange (ETDEWEB)

    Freeze, Geoffrey A.; Wang, Yifeng; Howard, Robert; McNeish, Jerry A.; Schultz, Peter Andrew; Arguello, Jose Guadalupe, Jr.

    2010-09-01

    This report describes the specification of a challenge problem and associated challenge milestones for the Waste Integrated Performance and Safety Codes (IPSC) supporting the U.S. Department of Energy (DOE) Office of Nuclear Energy Advanced Modeling and Simulation (NEAMS) Campaign. The NEAMS challenge problems are designed to demonstrate proof of concept and progress towards IPSC goals. The goal of the Waste IPSC is to develop an integrated suite of modeling and simulation capabilities to quantitatively assess the long-term performance of waste forms in the engineered and geologic environments of a radioactive waste storage or disposal system. The Waste IPSC will provide this simulation capability (1) for a range of disposal concepts, waste form types, engineered repository designs, and geologic settings, (2) for a range of time scales and distances, (3) with appropriate consideration of the inherent uncertainties, and (4) in accordance with robust verification, validation, and software quality requirements. To demonstrate proof of concept and progress towards these goals and requirements, a Waste IPSC challenge problem is specified that includes coupled thermal-hydrologic-chemical-mechanical (THCM) processes that describe (1) the degradation of a borosilicate glass waste form and the corresponding mobilization of radionuclides (i.e., the processes that produce the radionuclide source term), (2) the associated near-field physical and chemical environment for waste emplacement within a salt formation, and (3) radionuclide transport in the near field (i.e., through the engineered components - waste form, waste package, and backfill - and the immediately adjacent salt). The initial details of a set of challenge milestones that collectively comprise the full challenge problem are also specified.

  12. Introduction to special section of the Journal of Family Psychology, advances in mixed methods in family psychology: integrative and applied solutions for family science.

    Science.gov (United States)

    Weisner, Thomas S; Fiese, Barbara H

    2011-12-01

    Mixed methods in family psychology refer to the systematic integration of qualitative and quantitative techniques to represent family processes and settings. Over the past decade, significant advances have been made in study design, analytic strategies, and technological support (such as software) that allow for the integration of quantitative and qualitative methods and for making appropriate inferences from mixed methods. This special section of the Journal of Family Psychology illustrates how mixed methods may be used to advance knowledge in family science through identifying important cultural differences in family structure, beliefs, and practices, and revealing patterns of family relationships to generate new measurement paradigms and inform clinical practice. Guidance is offered to advance mixed methods research in family psychology through sound principles of peer review.

  13. Advancing Access, Attribution, and Integration of Earth & Ocean Science Data: Integrated Services of the Marine Geoscience Data System and the Geoinformatics for Geochemistry Program

    Science.gov (United States)

    Lehnert, K. A.; Carbotte, S. M.; Ferrini, V.; Arko, R. A.; Chan, S.; Ryan, W. B.

    2010-12-01

    Development and operation of digital data collections are needed across all areas of the earth and ocean sciences to ensure access and preservation of data sets collected in support of earth and ocean sciences in order to maximize the return on research investments, while enabling verification of research results and contributing to new science initiatives. This is particularly true for data sets that are acquired at high cost, particularly in the marine environment, and that contain irreplaceable observations made of earth’s dynamic properties. The Marine Geoscience Data System (MGDS, www.marine-geo.org) and the Geoinformatics for Geochemistry Program (GfG, www.geoinfogeochem.org) have over the past decade developed, maintained, and operated community-driven data collections that support the preservation, discovery, retrieval, and analysis of a wide range of observational field and analytical data types from the marine and terrestrial environments, among them the PetDB database, the EarthChem data network, the Ridge2000 and MARGINS databases, the Antarctic and Southern Ocean Data System (ASODS), the Global Multi Resolution Topography Synthesis, and the System for Earth Sample Registration (SESAR). MGDS and GfG systems have been developed based on an active understanding of the practices, needs, and concerns of their user communities. They have engaged investigators in the design of the systems, seeking their feedback, and educating the community about responsibilities and benefits of scientific data management and sharing, and worked with funding agencies, editors, publishers, professional societies, and researchers to achieve broad community support, to proactively drive the development of community standards and best practices for data submission, data publication, data documentation, and data archiving, and to advance implementation. In a new formal partnership named IEDA (Integrated Earth Data Applications), the MGDS and GfG will be funded by the US National

  14. Next Generation Solvent Performance in the Modular Caustic Side Solvent Extraction Process - 15495

    Energy Technology Data Exchange (ETDEWEB)

    Smith, Tara E. [Savannah River Remediation, LLC., Aiken, SC (United States); Scherman, Carl [Savannah River Remediation, LLC., Aiken, SC (United States); Martin, David [Savannah River Remediation, LLC., Aiken, SC (United States); Suggs, Patricia [Savannah River Site (SRS), Aiken, SC (United States)

    2015-01-14

    Changes to the Modular Caustic Side Solvent Extraction Unit (MCU) flow-sheet were implemented in the facility. Implementation included changing the scrub and strip chemicals and concentrations, modifying the O/A ratios for the strip, scrub, and extraction contactor banks, and blending the current BoBCalixC6 extractant-based solvent in MCU with clean MaxCalix extractant-based solvent. During the successful demonstration period, the MCU process was subject to rigorous oversight to ensure hydraulic stability and chemical/radionuclide analysis of the key process tanks (caustic wash tank, solvent hold tank, strip effluent hold tank, and decontaminated salt solution hold tank) to evaluate solvent carryover to downstream facilities and the effectiveness of cesium removal from the liquid salt waste. Results indicated the extraction of cesium was significantly more effective with an average Decontamination Factor (DF) of 1,129 (range was 107 to 1,824) and that stripping was effective. The contactor hydraulic performance was stable and satisfactory, as indicated by contactor vibration, contactor rotational speed, and flow stability; all of which remained at or near target values. Furthermore, the Solvent Hold Tank (SHT) level and specific gravity was as expected, indicating that solvent integrity and organic hydraulic stability were maintained. The coalescer performances were in the range of processing results under the BOBCalixC6 flow sheet, indicating negligible adverse impact of NGS deployment. After the Demonstration period, MCU began processing via routine operations. Results to date reiterate the enhanced cesium extraction and stripping capability of the Next Generation Solvent (NGS) flow sheet. This paper presents process performance results of the NGS Demonstration and continued operations of MCU utilizing the blended BobCalixC6-MaxCalix solvent under the NGS flowsheet.

  15. Organic solvent topical report

    Energy Technology Data Exchange (ETDEWEB)

    Cowley, W.L.

    1998-04-30

    This report is the technical basis for the accident and consequence analyses used in the Hanford Tank Farms Basis for Interim Operation. The report also contains the scientific and engineering information and reference material needed to understand the organic solvent safety issue. This report includes comments received from the Chemical Reactions Subcommittee of the Tank Advisory Panel.

  16. Organic solvent topical report

    Energy Technology Data Exchange (ETDEWEB)

    COWLEY, W.L.

    1999-05-13

    This report provides the basis for closing the organic solvent safety issue. Sufficient information is presented to conclude that risk posed by an organic solvent fire is within risk evaluation guidelines. This report updates information contained in Analysis of Consequences of Postulated Solvent Fires in Hanford Site Waste Tanks. WHC-SD-WM-CN-032. Rev. 0A (Cowley et al. 1996). However, this document will not replace Cowley et al (1996) as the primary reference for the Basis for Interim Operation (BIO) until the recently submitted BIO amendment (Hanson 1999) is approved by the US Department of Energy. This conclusion depends on the use of controls for preventing vehicle fuel fires and for limiting the use of flame cutting in areas where hot metal can fall on the waste surface.The required controls are given in the Tank Waste Remediation System Technical Safety Requirements (Noorani 1997b). This is a significant change from the conclusions presented in Revision 0 of this report. Revision 0 of this calcnote concluded that some organic solvent fire scenarios exceeded risk evaluation guidelines, even with controls imposed.

  17. Non-CAR resists and advanced materials for Massively Parallel E-Beam Direct Write process integration

    Science.gov (United States)

    Pourteau, Marie-Line; Servin, Isabelle; Lepinay, Kévin; Essomba, Cyrille; Dal'Zotto, Bernard; Pradelles, Jonathan; Lattard, Ludovic; Brandt, Pieter; Wieland, Marco

    2016-03-01

    The emerging Massively Parallel-Electron Beam Direct Write (MP-EBDW) is an attractive high resolution high throughput lithography technology. As previously shown, Chemically Amplified Resists (CARs) meet process/integration specifications in terms of dose-to-size, resolution, contrast, and energy latitude. However, they are still limited by their line width roughness. To overcome this issue, we tested an alternative advanced non-CAR and showed it brings a substantial gain in sensitivity compared to CAR. We also implemented and assessed in-line post-lithographic treatments for roughness mitigation. For outgassing-reduction purpose, a top-coat layer is added to the total process stack. A new generation top-coat was tested and showed improved printing performances compared to the previous product, especially avoiding dark erosion: SEM cross-section showed a straight pattern profile. A spin-coatable charge dissipation layer based on conductive polyaniline has also been tested for conductivity and lithographic performances, and compatibility experiments revealed that the underlying resist type has to be carefully chosen when using this product. Finally, the Process Of Reference (POR) trilayer stack defined for 5 kV multi-e-beam lithography was successfully etched with well opened and straight patterns, and no lithography-etch bias.

  18. Computational Aerodynamic Prediction for Integration of an Advanced Reconnaissance Pod on a 5th Generation Fighter Type Aircraft

    Directory of Open Access Journals (Sweden)

    De Paolis P

    2015-06-01

    Full Text Available In this paper a computational aerodynamic prediction to support the aeromechanical integration of an advanced reconnaissance pod on a 5th generation fighter type aircraft is presented. The aim of the activity was to compare the aerodynamic characteristics of the new pod to a previous one already cleared on the same aircraft fleet, given verified inertial and structural similarity. Verifying the aforementioned aerodynamic similarity without involving extensive flight test activity was a must, to save time and to reduce costs. A two steps approach was required by the Certification Authority to verify, initially, the performance data compatibility in terms of aerodynamic coefficients of the old pod with the new one, in order to allow performance flight manual data interchangeability (a quantitative comparison was required; afterwards, a qualitative assessment was conducted to verify the absence of unsteadiness induced by the introduction in the external structure of the new pod of an auxiliary antenna case. Computational results are presented both for Straight and Level Un-accelerated Flight and SteadySideslip flight conditions at different Angles of Attack.

  19. Advanced treatment of biologically pretreated coal gasification wastewater by a novel integration of three-dimensional catalytic electro-Fenton and membrane bioreactor.

    Science.gov (United States)

    Jia, Shengyong; Han, Hongjun; Hou, Baolin; Zhuang, Haifeng

    2015-12-01

    Laboratorial scale experiments were conducted to investigate a novel system three-dimensional catalytic electro-Fenton (3DCEF, catalyst of sewage sludge based activated carbon which loaded Fe3O4) integrating with membrane bioreactor (3DCEF-MBR) on advanced treatment of biologically pretreated coal gasification wastewater. The results indicated that 3DCEF-MBR represented high efficiencies in eliminating COD and total organic carbon, giving the maximum removal efficiencies of 80% and 75%, respectively. The integrated 3DCEF-MBR system significantly reduced the transmembrane pressure, giving 35% lower than conventional MBR after 30 days operation. The enhanced hydroxyl radical oxidation and bacteria self repair function were the mechanisms for 3DCEF-MBR performance. Therefore, the integrated 3DCEF-MBR was expected to be the promising technology for advanced treatment in engineering applications.

  20. Advanced MicroObserver UGS integration with and cueing of the BattleHawk squad level loitering munition and UAV

    Science.gov (United States)

    Steadman, Bob; Finklea, John; Kershaw, James; Loughman, Cathy; Shaffner, Patti; Frost, Dean; Deller, Sean

    2014-06-01

    Textron's Advanced MicroObserver(R) is a next generation remote unattended ground sensor system (UGS) for border security, infrastructure protection, and small combat unit security. The original MicroObserver(R) is a sophisticated seismic sensor system with multi-node fusion that supports target tracking. This system has been deployed in combat theaters. The system's seismic sensor nodes are uniquely able to be completely buried (including antennas) for optimal covertness. The advanced version adds a wireless day/night Electro-Optic Infrared (EOIR) system, cued by seismic tracking, with sophisticated target discrimination and automatic frame capture features. Also new is a field deployable Gateway configurable with a variety of radio systems and flexible networking, an important upgrade that enabled the research described herein. BattleHawkTM is a small tube launched Unmanned Air Vehicle (UAV) with a warhead. Using transmitted video from its EOIR subsystem an operator can search for and acquire a target day or night, select a target for attack, and execute terminal dive to destroy the target. It is designed as a lightweight squad level asset carried by an individual infantryman. Although BattleHawk has the best loiter time in its class, it's still relatively short compared to large UAVs. Also it's a one-shot asset in its munition configuration. Therefore Textron Defense Systems conducted research, funded internally, to determine if there was military utility in having the highly persistent MicroObserver(R) system cue BattleHawk's launch and vector it to beyond visual range targets for engagement. This paper describes that research; the system configuration implemented, and the results of field testing that was performed on a government range early in 2013. On the integrated system that was implemented, MicroObserver(R) seismic detections activated that system's camera which then automatically captured images of the target. The geo-referenced and time-tagged Micro

  1. Human Exploration System Test-Bed for Integration and Advancement (HESTIA) Support of Future NASA Deep-Space Missions

    Science.gov (United States)

    Marmolejo, Jose; Ewert, Michael

    2016-01-01

    The Engineering Directorate at the NASA - Johnson Space Center is outfitting a 20-Foot diameter hypobaric chamber in Building 7 to support future deep-space Environmental Control & Life Support System (ECLSS) research as part of the Human Exploration System Test-bed for Integration and Advancement (HESTIA) Project. This human-rated chamber is the only NASA facility that has the unique experience, chamber geometry, infrastructure, and support systems capable of conducting this research. The chamber was used to support Gemini, Apollo, and SkyLab Missions. More recently, it was used to conduct 30-, 60-, and 90-day human ECLSS closed-loop testing in the 1990s to support the International Space Station and life support technology development. NASA studies show that both planetary surface and deep-space transit crew habitats will be 3-4 story cylindrical structures driven by human occupancy volumetric needs and launch vehicle constraints. The HESTIA facility offers a 3-story, 20-foot diameter habitat consistent with the studies' recommendations. HESTIA operations follow stringent processes by a certified test team that including human testing. Project management, analysis, design, acquisition, fabrication, assembly and certification of facility build-ups are available to support this research. HESTIA offers close proximity to key stakeholders including astronauts, Human Research Program (who direct space human research for the agency), Mission Operations, Safety & Mission Assurance, and Engineering Directorate. The HESTIA chamber can operate at reduced pressure and elevated oxygen environments including those proposed for deep-space exploration. Data acquisition, power, fluids and other facility resources are available to support a wide range of research. Recently completed HESTIA research consisted of unmanned testing of ECLSS technologies. Eventually, the HESTIA research will include humans for extended durations at reduced pressure and elevated oxygen to demonstrate

  2. Putting Integrated Systems Health Management Capabilities to Work: Development of an Advanced Caution and Warning System for Next-Generation Crewed Spacecraft Missions

    Science.gov (United States)

    Mccann, Robert S.; Spirkovska, Lilly; Smith, Irene

    2013-01-01

    Integrated System Health Management (ISHM) technologies have advanced to the point where they can provide significant automated assistance with real-time fault detection, diagnosis, guided troubleshooting, and failure consequence assessment. To exploit these capabilities in actual operational environments, however, ISHM information must be integrated into operational concepts and associated information displays in ways that enable human operators to process and understand the ISHM system information rapidly and effectively. In this paper, we explore these design issues in the context of an advanced caution and warning system (ACAWS) for next-generation crewed spacecraft missions. User interface concepts for depicting failure diagnoses, failure effects, redundancy loss, "what-if" failure analysis scenarios, and resolution of ambiguity groups are discussed and illustrated.

  3. The necessity of the use of social networks as an ingredient of computer-integrated marketing communications for advancement of higher educational establishments

    Directory of Open Access Journals (Sweden)

    Kostiuk Mariia

    2016-04-01

    Full Text Available The volume of demand and supply on educational services constantly grows and education becomes the perspective sphere of the Ukrainian economy. In the conditions of the permanent increased competition between educational establishments, it is impossible to do without marketing, namely - to marketing of educational services. The article substantiates the necessity of the use of computer-integrated marketing communications in advancement of higher educational establishment. It considers questions of advancement of higher educational establishments and educational services in Internet, analyses indexes of advancement of higher educational establishment in «VKontakte» social network. The recommendations for the promotion of universities in social networks were formulated on the basis of the study results.

  4. AISI/DOE Advanced Process Control Program Vol. 3 of 6 Microstructure Engineering in Hot Strip Mills, Part 1 of 2: Integrated Mathematical Model

    Energy Technology Data Exchange (ETDEWEB)

    J.K. Brimacombe; I.V. Samarasekera; E.B. Hawbolt; T.R. Meadowcroft; M. Militzer; W.J. Pool; D.Q. Jin

    1999-07-31

    This report describes the work of developing an integrated model used to predict the thermal history, deformation, roll forces, microstructural evolution and mechanical properties of steel strip in a hot-strip mill. This achievement results from a joint research effort that is part of the American Iron and Steel Institute's (AIS) Advanced Process Control Program, a collaboration between the U.S. DOE and fifteen North American Steelmakers.

  5. Occupational solvent exposure and cognition

    Science.gov (United States)

    Sabbath, E.L.; Glymour, M.M.; Berr, C.; Singh-Manoux, A.; Zins, M.; Goldberg, M.

    2012-01-01

    Objective: Chronic occupational solvent exposure is associated with long-term cognitive deficits. Cognitive reserve may protect solvent-exposed workers from cognitive impairment. We tested whether the association between chronic solvent exposure and cognition varied by educational attainment, a proxy for cognitive reserve. Methods: Data were drawn from a prospective cohort of French national gas and electricity (GAZEL) employees (n = 4,134). Lifetime exposure to 4 solvent types (chlorinated solvents, petroleum solvents, benzene, and nonbenzene aromatic solvents) was assessed using a validated job-exposure matrix. Education was dichotomized at less than secondary school or below. Cognitive impairment was defined as scoring below the 25th percentile on the Digit Symbol Substitution Test at mean age 59 (SD 2.8; 88% of participants were retired at testing). Log-binomial regression was used to model risk ratios (RRs) for poor cognition as predicted by solvent exposure, stratified by education and adjusted for sociodemographic and behavioral factors. Results: Solvent exposure rates were higher among less-educated patients. Within this group, there was a dose-response relationship between lifetime exposure to each solvent type and RR for poor cognition (e.g., for high exposure to benzene, RR = 1.24, 95% confidence interval 1.09–1.41), with significant linear trends (p < 0.05) in 3 out of 4 solvent types. Recency of solvent exposure also predicted worse cognition among less-educated patients. Among those with secondary education or higher, there was no significant or near-significant relationship between any quantification of solvent exposure and cognition. Conclusions: Solvent exposure is associated with poor cognition only among less-educated individuals. Higher cognitive reserve in the more-educated group may explain this finding. PMID:22641403

  6. Solvent effects in chemistry

    CERN Document Server

    Buncel, Erwin

    2015-01-01

    This book introduces the concepts, theory and experimental knowledge concerning solvent effects on the rate and equilibrium of chemical reactions of all kinds.  It begins with basic thermodynamics and kinetics, building on this foundation to demonstrate how a more detailed understanding of these effects may be used to aid in determination of reaction mechanisms, and to aid in planning syntheses. Consideration is given to theoretical calculations (quantum chemistry, molecular dynamics, etc.), to statistical methods (chemometrics), and to modern day concerns such as ""green"" chemistry, where ut

  7. Essential roles of protein-solvent many-body correlation in solvent-entropy effect on protein folding and denaturation: comparison between hard-sphere solvent and water.

    Science.gov (United States)

    Oshima, Hiraku; Kinoshita, Masahiro

    2015-04-14

    In earlier works, we showed that the entropic effect originating from the translational displacement of water molecules plays the pivotal role in protein folding and denaturation. The two different solvent models, hard-sphere solvent and model water, were employed in theoretical methods wherein the entropic effect was treated as an essential factor. However, there were similarities and differences in the results obtained from the two solvent models. In the present work, to unveil the physical origins of the similarities and differences, we simultaneously consider structural transition, cold denaturation, and pressure denaturation for the same protein by employing the two solvent models and considering three different thermodynamic states for each solvent model. The solvent-entropy change upon protein folding/unfolding is decomposed into the protein-solvent pair (PA) and many-body (MB) correlation components using the integral equation theories. Each component is further decomposed into the excluded-volume (EV) and solvent-accessible surface (SAS) terms by applying the morphometric approach. The four physically insightful constituents, (PA, EV), (PA, SAS), (MB, EV), and (MB, SAS), are thus obtained. Moreover, (MB, SAS) is discussed by dividing it into two factors. This all-inclusive investigation leads to the following results: (1) the protein-water many-body correlation always plays critical roles in a variety of folding/unfolding processes; (2) the hard-sphere solvent model fails when it does not correctly reproduce the protein-water many-body correlation; (3) the hard-sphere solvent model becomes problematic when the dependence of the many-body correlation on the solvent number density and temperature is essential: it is not quite suited to studies on cold and pressure denaturating of a protein; (4) when the temperature and solvent number density are limited to the ambient values, the hard-sphere solvent model is usually successful; and (5) even at the ambient

  8. Science based integrated approach to advanced nuclear fuel development - integrated multi-scale multi-physics hierarchical modeling and simulation framework Part III: cladding

    Energy Technology Data Exchange (ETDEWEB)

    Tome, Carlos N [Los Alamos National Laboratory; Caro, J A [Los Alamos National Laboratory; Lebensohn, R A [Los Alamos National Laboratory; Unal, Cetin [Los Alamos National Laboratory; Arsenlis, A [LLNL; Marian, J [LLNL; Pasamehmetoglu, K [INL

    2010-01-01

    Advancing the performance of Light Water Reactors, Advanced Nuclear Fuel Cycles, and Advanced Reactors, such as the Next Generation Nuclear Power Plants, requires enhancing our fundamental understanding of fuel and materials behavior under irradiation. The capability to accurately model the nuclear fuel systems to develop predictive tools is critical. Not only are fabrication and performance models needed to understand specific aspects of the nuclear fuel, fully coupled fuel simulation codes are required to achieve licensing of specific nuclear fuel designs for operation. The backbone of these codes, models, and simulations is a fundamental understanding and predictive capability for simulating the phase and microstructural behavior of the nuclear fuel system materials and matrices. In this paper we review the current status of the advanced modeling and simulation of nuclear reactor cladding, with emphasis on what is available and what is to be developed in each scale of the project, how we propose to pass information from one scale to the next, and what experimental information is required for benchmarking and advancing the modeling at each scale level.

  9. The construction, prediction and measurement of co-crystal ternary phase diagrams as a tool for solvent selection.

    Science.gov (United States)

    Holaň, Jan; Stěpánek, František; Billot, Pascal; Ridvan, Luděk

    2014-10-15

    Many active pharmaceutical ingredients (APIs) are poorly soluble and therefore poorly bioavailable. In recent years, the advances in crystal engineering have motivated the research in the design of pharmaceutical co-crystals. This study examines the combination of solvent selection and co-crystal ternary phase diagram prediction on the basis of solubility measurements into a single methodology that can be integrated into the pharmaceutical process development workflow. Ternary diagrams constructed from agomelatine citric acid co-crystal solubility data were compared with those obtained by modern calorimetric method called discontinuous isoperibolic thermal analysis (DITA). A suitable solvent for the co-crystallization process has been chosen on the basis of agomelatine citric acid co-crystal solubility, which is connected to the yield of the crystallization process. Furthermore, the quality of final crystals from crystallization experiments was evaluated.

  10. Dispersion of Single-Walled Carbon Nanotubes in Organic Solvents

    OpenAIRE

    Cheng, Qiaohuan

    2010-01-01

    This thesis contains a systematic study of the dispersion of pristine HiPco Single Walled Carbon Nanotubes (SWNTs) in a series of organic solvents. A double beamed UV-Vis-NIR absorption spectrometer coupled with an integrating sphere was employed to demonstrate the dispersibility of SWNTs in different solvents. Raman Spectroscopy and Atomic Force Microscopy (AFM) were used to confirm the debundling and exfoliation of SWNTs aggregates. An investigation of the solubility of SWNTs in four chlori...

  11. Advanced W-Band Gallium Nitride Monolithic Microwave Integrated Circuits (MMICs) for Cloud Doppler Radar Supporting ACE Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Develop W-band Gallium Nitride (GaN) MMICs to enable the advanced cross-track scanning, dual-frequency Doppler cloud radar concept in support of the...

  12. 'Integration'

    DEFF Research Database (Denmark)

    Olwig, Karen Fog

    2011-01-01

    After a long history dominated by out-migration, Denmark, Norway and Sweden have, in the past 50 years, become immigration societies. This article compares how these Scandinavian welfare societies have sought to incorporate immigrants and refugees into their national communities. It suggests that......, while the countries have adopted disparate policies and ideologies, differences in the actual treatment and attitudes towards immigrants and refugees in everyday life are less clear, due to parallel integration programmes based on strong similarities in the welfare systems and in cultural notions...... of equality in the three societies. Finally, it shows that family relations play a central role in immigrants’ and refugees’ establishment of a new life in the receiving societies, even though the welfare society takes on many of the social and economic functions of the family....

  13. Endocervical ultrasound applicator for integrated hyperthermia and HDR brachytherapy in the treatment of locally advanced cervical carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Wootton, Jeffery H.; Hsu, I-Chow Joe; Diederich, Chris J. [Thermal Therapy Research Group, Department of Radiation Oncology, University of California, San Francisco, California 94115 (United States) and Joint Graduate Group in Bioengineering, University of California, Berkeley and San Francisco, California 94115 (United States)

    2011-02-15

    Purpose: The clinical success of hyperthermia adjunct to radiotherapy depends on adequate temperature elevation in the tumor with minimal temperature rise in organs at risk. Existing technologies for thermal treatment of the cervix have limited spatial control or rapid energy falloff. The objective of this work is to develop an endocervical applicator using a linear array of multisectored tubular ultrasound transducers to provide 3-D conformal, locally targeted hyperthermia concomitant to radiotherapy in the uterine cervix. The catheter-based device is integrated within a HDR brachytherapy applicator to facilitate sequential and potentially simultaneous heat and radiation delivery. Methods: Treatment planning images from 35 patients who underwent HDR brachytherapy for locally advanced cervical cancer were inspected to assess the dimensions of radiation clinical target volumes (CTVs) and gross tumor volumes (GTVs) surrounding the cervix and the proximity of organs at risk. Biothermal simulation was used to identify applicator and catheter material parameters to adequately heat the cervix with minimal thermal dose accumulation in nontargeted structures. A family of ultrasound applicators was fabricated with two to three tubular transducers operating at 6.6-7.4 MHz that are unsectored (360 deg.), bisectored (2x180 deg.), or trisectored (3x120 deg.) for control of energy deposition in angle and along the device length in order to satisfy anatomical constraints. The device is housed in a 6 mm diameter PET catheter with cooling water flow for endocervical implantation. Devices were characterized by measuring acoustic efficiencies, rotational acoustic intensity distributions, and rotational temperature distributions in phantom. Results: The CTV in HDR brachytherapy plans extends 20.5{+-}5.0 mm from the endocervical tandem with the rectum and bladder typically <8 mm from the target boundary. The GTV extends 19.4{+-}7.3 mm from the tandem. Simulations indicate that for 60

  14. Advanced Development of a Compact 5-15 lbf Lox/Methane Thruster for an Integrated Reaction Control and Main Engine Propulsion System

    Science.gov (United States)

    Hurlbert, Eric A.; McManamen, John Patrick; Sooknanen, Josh; Studak, Joseph W.

    2011-01-01

    This paper describes the advanced development and testing of a compact 5 to 15 lbf LOX/LCH4 thruster for a pressure-fed integrated main engine and RCS propulsion system to be used on a spacecraft "vertical" test bed (VTB). The ability of the RCS thruster and the main engine to operate off the same propellant supply in zero-g reduces mass and improves mission flexibility. This compact RCS engine incorporates several features to dramatically reduce mass and parts count, to ease manufacturing, and to maintain acceptable performance given that specific impulse (Isp) is not the driver. For example, radial injection holes placed on the chamber body for easier drilling, and high temperature Haynes 230 were selected for the chamber over other more expensive options. The valve inlets are rotatable before welding allowing different orientations for vehicle integration. In addition, the engine design effort selected a coil-on-plug ignition system which integrates a relay and coil with the plug electrode, and moves some exciter electronics to avionics driver board. The engine injector design has small dribble volumes to target minimum pulse widths of 20 msec. and an efficient minimum impulse bit of less than 0.05 lbf-sec. The propellants, oxygen and methane, were chosen because together they are a non-toxic, Mars-forward, high density, space storable, and high performance propellant combination that is capable of pressure-fed and pump-fed configurations and integration with life support and power subsystems. This paper will present the results of the advanced development testing to date of the RCS thruster and the integration with a vehicle propulsion system.

  15. Integrated Advanced Microwave Sounding Unit-A (AMSU-A). As-Designed Parts List: Electrical, Electronic, and Electromechanical (EEE) As-Built Parts List for the AMSU-A Instruments

    Science.gov (United States)

    2000-01-01

    This is the As-Designed Parts List, Electrical, Electronic, and Electromechanical (EEE) As-Built Parts Lists For The AMSU-A Instruments, for the Integrated Advanced Microwave Sounding Unit-A (AMSU-A).

  16. Equipment concept design and development plans for microgravity science and applications research on space station: Combustion tunnel, laser diagnostic system, advanced modular furnace, integrated electronics laboratory

    Science.gov (United States)

    Uhran, M. L.; Youngblood, W. W.; Georgekutty, T.; Fiske, M. R.; Wear, W. O.

    1986-01-01

    Taking advantage of the microgravity environment of space NASA has initiated the preliminary design of a permanently manned space station that will support technological advances in process science and stimulate the development of new and improved materials having applications across the commercial spectrum. Previous studies have been performed to define from the researcher's perspective, the requirements for laboratory equipment to accommodate microgravity experiments on the space station. Functional requirements for the identified experimental apparatus and support equipment were determined. From these hardware requirements, several items were selected for concept designs and subsequent formulation of development plans. This report documents the concept designs and development plans for two items of experiment apparatus - the Combustion Tunnel and the Advanced Modular Furnace, and two items of support equipment the Laser Diagnostic System and the Integrated Electronics Laboratory. For each concept design, key technology developments were identified that are required to enable or enhance the development of the respective hardware.

  17. SOLVENT EXTRACTION OF URANIUM VALUES

    Science.gov (United States)

    Feder, H.M.; Ader, M.; Ross, L.E.

    1959-02-01

    A process is presented for extracting uranium salt from aqueous acidic solutions by organic solvent extraction. It consists in contacting the uranium bearing solution with a water immiscible dialkylacetamide having at least 8 carbon atoms in the molecule. Mentioned as a preferred extractant is dibutylacetamide. The organic solvent is usually used with a diluent such as kerosene or CCl/sub 4/.

  18. Selection and design of solvents

    DEFF Research Database (Denmark)

    Gani, Rafiqul

    . With increasing interest on issues such as waste, sustainability, environmental impact and green chemistry, the selection and design of solvents have become important problems that need to be addressed during chemical product-process design and development. Systematic methods and tools suitable for selection...... and design of solvents will be presented together with application examples. The selection problem is defined as finding known chemicals that match the desired functions of a solvent for a specified set of applications. The design problem is defined as finding the molecular structure (or mixture of molecules......) that match the desired functions of a solvent for a specified set of applications. Use of organic chemicals and ionic liquids as solvents will be covered....

  19. Solvent degradation products in nuclear fuel processing solvents

    Energy Technology Data Exchange (ETDEWEB)

    Shook, H.E. Jr.

    1988-06-01

    The Savannah River Plant uses a modified Purex process to recover enriched uranium and separate fission products. This process uses 7.5% tri-n-butyl phosphate (TBP) dissolved in normal paraffin hydrocarbons for the solvent extraction of a nitric acid solution containing the materials to be separated. Periodic problems in product decontamination result from solvent degradation. A study to improve process efficiency has identified certain solvent degradation products and suggested mitigation measures. Undecanoic acid, lauric acid, and tridecanoic acid were tentatively identified as diluent degradation products in recycle solvent. These long-chain organic acids affect phase separation and lead to low decontamination factors. Solid phase extraction (SPE) was used to concentrate the organic acids in solvent prior to analysis by high performance liquid chromatography (HPLC). SPE and HPLC methods were optimized in this work for analysis of decanoic acid, undecanoic acid, and lauric acid in solvent. Accelerated solvent degradation studies with 7.5% TBP in normal paraffin hydrocarbons showed that long-chain organic acids and long-chain alkyl butyl phosphoric acids are formed by reactions with nitric acid. Degradation of both tributyl phosphate and hydrocarbon can be minimized with purified normal paraffin replacing the standard grade presently used. 12 refs., 1 fig., 3 tabs.

  20. Best of Both Worlds: A Conceptual Model for Integrating an Aging Specialization within an Advanced Generalist MSW Program

    Science.gov (United States)

    Dakin, Emily K.; Quijano, Louise M.; Bishop, Pamela S.; Sheafor, Bradford W.

    2015-01-01

    Must a master's of social work (MSW) program's orientation be either advanced generalist or some form of specialist? Or is there the possibility of a hybrid curriculum that provides enough breadth to prepare MSW graduates for a wide range of social work jobs, but that also addresses students' and community agencies' demands for student…

  1. Switchable Polarity Solvents: Are They Green?

    Science.gov (United States)

    Plaumann, Heinz

    2017-03-01

    Solvents play an incredibly important role in large scale chemical reactions. Switchable polarity solvents may prove to be a class of solvent that offers energy and material efficiencies greater than existing solvents. This paper examines such solvents and their potential in a variety of chemical reactions.

  2. Integrated Advanced Microwave Sounding Unit-A (AMSU-A). As-Designed Parts List: Electrical, Electronic and Electromechanical (EEE) As-Designed Parts List

    Science.gov (United States)

    Lorenz, E.

    1999-01-01

    This report comprises the Electrical, Electronic, and Electromechanical (EEE) As Designed Parts List to be used in the Integrated Advanced Microwave Sounding Unit-A (AMSU-A) instrument. The purpose of the EEE As-Designed Parts List is to provide a listing of EEE parts identified for use on the Integrated AMSU-A. All EEE parts used on the AMSU-A must meet the parts control requirements as defined in the Parts Control Plan (POP). All part applications are reviewed by the Parts Control Board (PCB) and granted approval if POP requirements are met. The "As Designed Parts Lists" indicates PCB approval status, and thus also serves as the Program Approved Parts List.

  3. Preliminary experimental results using the thermal-hydraulic integral test facility (VISTA) for the pilot plant of the system integrated modular advanced reactor, SMART-P

    Energy Technology Data Exchange (ETDEWEB)

    Choi, Ki Yong; Pak, Hyun Sik; Cho, Seok; Pak, Choon Kyung; Lee, Sung Jae; Song, Chul Hwa; Chung, Moon Ki [KAERI, Taejon (Korea, Republic of)

    2003-07-01

    Preliminary experimental tests were carried out using the thermal-hydraulic integral test facility, VISTA (Experimental Verification by Integral Simulation of Transients and Accidents), which has been constructed to simulate the SMART-P. The VISTA facility is an integral test facility including the primary and secondary systems as well as safety-related Passive Residual heat removal (PRHR) systems. Its scaled ratio with respect to the SMART-P is 1/1 in height and 1/96 in volume and heater power. So far, several steady states and transient tests have been carried out to verify the overall thermal hydraulic primary and secondary characteristics in a range of 10% to 100% power operation. As results of preliminary results, the steady state conditions were found to coincide with the expected design values of the SMART-P. But the major thermal hydraulic parameters are greatly affected by the initial water level and the nitrogen pressure in the reactor upper annular cavity. In the PRHR transient tests, the steam inlet temperature of the PRHR system is found to drop suddenly from a superheated condition to a saturated condition at the end period of PRHR operation.

  4. To Explore the Chinese Medicine Syndrome Types and Integrative Therapy from Clinical Relative Factors of Patients with Advanced Prostate Cancer

    Institute of Scientific and Technical Information of China (English)

    王伊光

    2009-01-01

    Current Situation and Problems of the Treatment in Advanced Prostate Cancer In recent years,the incidence of prostate cancer shows a rising trend in China with an increase of 70%and has been the first place in the growth rate of malignant tumor in the male reproductive system. Prostate cancer has become a serious threat to male senior's health.Because of the application of

  5. Handbook of organic solvent properties

    CERN Document Server

    Smallwood, Ian

    2012-01-01

    The properties of 72 of the most commonly used solvents are given, tabulated in the most convenient way, making this book a joy for industrial chemists to use as a desk reference. The properties covered are those which answer the basic questions of: Will it do the job? Will it harm the user? Will it pollute the air? Is it easy to handle? Will it pollute the water? Can it be recovered or incinerated? These are all factors that need to be considered at the early stages of choosing a solvent for a new product or process.A collection of the physical properties of most commonly used solvents, their

  6. The Solvent Selection framework: solvents for organic synthesis, separation processes and ionic-organic synthesis

    DEFF Research Database (Denmark)

    Mitrofanov, Igor; Sansonetti, Sascha; Abildskov, Jens;

    2012-01-01

    problems are presented: 1) solvent selection and design for organic synthesis, 2) solvent screening and design of solvent mixtures for pharmaceutical applications and 3) ionic liquids selection and design as solvents. The application of the framework is highlighted successfully through case studies...... focusing on solvent replacement problem in organic synthesis and solvent mixture design for ibuprofen respectively....

  7. Bio-refinery of orange peels waste: a new concept based on integrated green and solvent free extraction processes using ultrasound and microwave techniques to obtain essential oil, polyphenols and pectin.

    Science.gov (United States)

    Boukroufa, Meryem; Boutekedjiret, Chahrazed; Petigny, Loïc; Rakotomanomana, Njara; Chemat, Farid

    2015-05-01

    In this study, extraction of essential oil, polyphenols and pectin from orange peel has been optimized using microwave and ultrasound technology without adding any solvent but only "in situ" water which was recycled and used as solvent. The essential oil extraction performed by Microwave Hydrodiffusion and Gravity (MHG) was optimized and compared to steam distillation extraction (SD). No significant changes in yield were noticed: 4.22 ± 0.03% and 4.16 ± 0.05% for MHG and SD, respectively. After extraction of essential oil, residual water of plant obtained after MHG extraction was used as solvent for polyphenols and pectin extraction from MHG residues. Polyphenols extraction was performed by ultrasound-assisted extraction (UAE) and conventional extraction (CE). Response surface methodology (RSM) using central composite designs (CCD) approach was launched to investigate the influence of process variables on the ultrasound-assisted extraction (UAE). The statistical analysis revealed that the optimized conditions of ultrasound power and temperature were 0.956 W/cm(2) and 59.83°C giving a polyphenol yield of 50.02 mgGA/100 g dm. Compared with the conventional extraction (CE), the UAE gave an increase of 30% in TPC yield. Pectin was extracted by conventional and microwave assisted extraction. This technique gives a maximal yield of 24.2% for microwave power of 500 W in only 3 min whereas conventional extraction gives 18.32% in 120 min. Combination of microwave, ultrasound and the recycled "in situ" water of citrus peels allow us to obtain high added values compounds in shorter time and managed to make a closed loop using only natural resources provided by the plant which makes the whole process intensified in term of time and energy saving, cleanliness and reduced waste water.

  8. Astragalus polysaccharide injection integrated with vinorelbine and cisplatin for patients with advanced non-small cell lung cancer: effects on quality of life and survival.

    Science.gov (United States)

    Guo, Li; Bai, Shu-Ping; Zhao, Ling; Wang, Xiao-Hong

    2012-09-01

    A platinum-based two-drug regimen is currently the standard of care for patients with advanced non-small-cell lung cancer (NSCLC). However, chemotherapy-induced side effects still remain a significant clinical problem. Astragalus polysaccharide (APS) is a polysaccharide isolated from the radix of astragalus membranaceus, a commonly used herbal compound in traditional Chinese medicine. APS was reported to increase tumor response, stabilize and improve performance status, and reduce chemotherapy toxicity. We designed this trial to determine whether APS injection integrated with vinorelbine and cisplatin (VC) offered an improved QOL over VC for patients with advanced NSCLC. Secondary objectives were tumor response, toxicity, and survival results. One hundred thirty-six patients with histologically or cytologically confirmed NSCLC were enrolled in this study from May 2008 to March 2010. Patients were randomized to receive either VC (VC arm) or VC combined with APS (VC-APS arm). The objective response rate of was 42.64% in the VC-APS arm and 36.76% in the VC arm. The difference was not statistically significant (P = 0.483). Median survival time was 10.7 and 10.2 months (P = 0.76) in VC-APS arm and VC arm, with 1-year survival rates of 35.3 and 32.4% (P = 0.717), respectively. After 3 cycles of treatment, there were significant differences in the overall patient QOL (P = 0.003), physical function (P = 0.01), fatigue (P pain (P = 0.007), and loss of appetite (P = 0.023) between the two study groups. In summary, we have proved that the treatment of APS integrated with VC had significantly improved QOL in patients with advanced NSCLC compared with VC alone.

  9. Hansen Cleaning Solvent Research Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Environmental regulation will force current baseline  precision cleaning solvent (AK-225) to be phased out starting 2015. We plan to develop  a new...

  10. Integrated Approach for a Knowledge-Based Process Layout for Simultaneous 5-Axis Milling of Advanced Materials

    Directory of Open Access Journals (Sweden)

    F. Klocke

    2011-01-01

    Full Text Available Advanced materials, like nickel-based alloys, gain importance in turbomachinery manufacturing, where creating complex surfaces constitute a major challenge. However, milling strategies that provide high material removal rates at acceptable tooling costs demand optimized tool geometry and process parameter selection. In this paper, a description of circular milling is given, focusing on resulting engagement conditions. Regarding this, a test bench was designed to investigate the chip formation process in an analogy milling process. Furthermore, the methodology for the approach in the analogy process was developed. Results of a first test run in Inconel 718 verify the presented approach.

  11. Applied biotransformations in green solvents.

    Science.gov (United States)

    Hernáiz, María J; Alcántara, Andrés R; García, José I; Sinisterra, José V

    2010-08-16

    The definite interest in implementing sustainable industrial technologies has impelled the use of biocatalysts (enzymes or cells), leading to high chemo-, regio- and stereoselectivities under mild conditions. As usual substrates are not soluble in water, the employ of organic solvents is mandatory. We will focus on different attempts to combine the valuable properties of green solvents with the advantages of using biocatalysts for developing cleaner synthetic processes.

  12. Advances in integrated and sustainable supply chain planning concepts, methods, tools and solution approaches toward a platform for industrial practice

    CERN Document Server

    Laínez-Aguirre, José Miguel

    2015-01-01

    Decision making at the enterprise level often encompass not only production operations and  product R&D, but other strategic functions such as financial planning and marketing. With the aim of maximizing growth and a firm’s value, companies often focus on co-ordinating these functional components as well as traditional hierarchical decision levels. Understanding this interplay can enhance enterprise capabilities of adaptation and response to uncertainties arising from internal processes as well as the external environment. This book presents concepts, methods, tools and solutions based on mathematical programming, which provides the quantitative support needed for integrated decision-making and ultimately for improving the allocation of overall corporate resources (e.g., materials, cash and personnel). Through a systems perspective, the integrated planning of the supply chain also promotes activities of reuse, reduction and recycling for achieving more sustainable environmental impacts of production/di...

  13. Comparative and integrative environmental assessment of advanced wastewater treatment processes based on an average removal of pharmaceuticals.

    Science.gov (United States)

    Igos, Elorri; Benetto, Enrico; Venditti, Silvia; Köhler, Christian; Cornelissen, Alex

    2013-01-01

    Pharmaceuticals are normally barely removed by conventional wastewater treatments. Advanced technologies as a post-treatment, could prevent these pollutants reaching the environment and could be included in a centralized treatment plant or, alternatively, at the primary point source, e.g. hospitals. In this study, the environmental impacts of different options, as a function of several advanced treatments as well as the centralized/decentralized implementation options, have been evaluated using Life Cycle Assessment (LCA) methodology. In previous publications, the characterization of the toxicity of pharmaceuticals within LCA suffers from high uncertainties. In our study, LCA was therefore only used to quantify the generated impacts (electricity, chemicals, etc.) of different treatment scenarios. These impacts are then weighted by the average removal rate of pharmaceuticals using a new Eco-efficiency Indicator EFI. This new way of comparing the scenarios shows significant advantages of upgrading a centralized plant with ozonation as the post-treatment. The decentralized treatment option reveals no significant improvement on the avoided environmental impact, due to the comparatively small pollutant load coming from the hospital and the uncertainties in the average removal of the decentralized scenarios. When comparing the post-treatment technologies, UV radiation has a lower performance than both ozonation and activated carbon adsorption.

  14. NREL/SCE High-Penetration PV Integration Project: Report on Field Demonstration of Advanced Inverter Functionality in Fontana, CA

    Energy Technology Data Exchange (ETDEWEB)

    Mather, B.

    2014-08-01

    The National Renewable Energy Laboratory/Southern California Edison High-Penetration PV Integration Project is (1) researching the distribution system level impacts of high-penetration photovoltaic (PV) integration, (2) determining mitigation methods to reduce or eliminate those impacts, and (3) seeking to demonstrate these mitigation methods on actual high-penetration PV distribution circuits. This report describes a field demonstration completed during the fall of 2013 on the Fontana, California, study circuit, which includes a total of 4.5 MW of interconnected utility-scale rooftop PV systems. The demonstration included operating a 2-MW PV system at an off-unity power factor that had been determined during previously completed distribution system modeling and PV impact assessment analyses. Data on the distribution circuit and PV system operations were collected during the 2-week demonstration period. This demonstration reinforces the findings of previous laboratory testing that showed that utility-scale PV inverters are capable of operating at off-unity power factor to mitigate PV impacts; however, because of difficulties setting and retaining PV inverter power factor set points during the field demonstration, it was not possible to demonstrate the effectiveness of off-unity power factor operation to mitigate the voltage impacts of high-penetration PV integration. Lessons learned from this field demonstration are presented to inform future field demonstration efforts.

  15. A novel integration of three-dimensional electro-Fenton and biological activated carbon and its application in the advanced treatment of biologically pretreated Lurgi coal gasification wastewater.

    Science.gov (United States)

    Hou, Baolin; Han, Hongjun; Zhuang, Haifeng; Xu, Peng; Jia, Shengyong; Li, Kun

    2015-11-01

    A novel integrated process with three-dimensional electro-Fenton (3D EF) and biological activated carbon (BAC) was employed in advanced treatment of biologically pretreated Lurgi coal gasification wastewater. SAC-Fe (sludge deserved activated carbon from sewage and iron sludge) and SAC (sludge deserved activated carbon) were used in 3D EF as catalytic particle electrodes (CPEs) and in BAC as carriers respectively. Results indicated that 3D EF with SAC-Fe as CPEs represented excellent pollutants and COLOR removals as well as biodegradability improvement. The efficiency enhancement attributed to generating more H2O2 and OH. The integrated process exhibited efficient performance of COD, BOD5, total phenols, TOC, TN and COLOR removals at a much shorter retention time, with the corresponding concentrations in effluent of 31.18, 6.69, 4.29, 17.82, 13.88mg/L and <20 times, allowing discharge criteria to be met. The integrated system was efficient, cost-effective and ecological sustainable and could be a promising technology for engineering applications.

  16. VOCs elimination and health risk reduction in e-waste dismantling workshop using integrated techniques of electrostatic precipitation with advanced oxidation technologies.

    Science.gov (United States)

    Chen, Jiangyao; Huang, Yong; Li, Guiying; An, Taicheng; Hu, Yunkun; Li, Yunlu

    2016-01-25

    Volatile organic compounds (VOCs) emitted during the electronic waste dismantling process (EWDP) were treated at a pilot scale, using integrated electrostatic precipitation (EP)-advanced oxidation technologies (AOTs, subsequent photocatalysis (PC) and ozonation). Although no obvious alteration was seen in VOC concentration and composition, EP technology removed 47.2% of total suspended particles, greatly reducing the negative effect of particles on subsequent AOTs. After the AOT treatment, average removal efficiencies of 95.7%, 95.4%, 87.4%, and 97.5% were achieved for aromatic hydrocarbons, aliphatic hydrocarbons, halogenated hydrocarbons, as well as nitrogen- and oxygen-containing compounds, respectively, over 60-day treatment period. Furthermore, high elimination capacities were also seen using hybrid technique of PC with ozonation; this was due to the PC unit's high loading rates and excellent pre-treatment abilities, and the ozonation unit's high elimination capacity. In addition, the non-cancer and cancer risks, as well as the occupational exposure cancer risk, for workers exposed to emitted VOCs in workshop were reduced dramatically after the integrated technique treatment. Results demonstrated that the integrated technique led to highly efficient and stable VOC removal from EWDP emissions at a pilot scale. This study points to an efficient approach for atmospheric purification and improving human health in e-waste recycling regions.

  17. Molecular Modeling of Enzyme Dynamics Towards Understanding Solvent Effects

    DEFF Research Database (Denmark)

    Wedberg, Nils Hejle Rasmus Ingemar

    the concentration of water in a region of the simulation box far from the protein surface. In order to evaluate the corresponding activity, a previously developed methodology based on fluctuation solution theory is employed to compute the excess Gibbs energy of the water/organic solvent mixture. This requires...... that separate simulations of this mixture are carried out at different compositions, and that the total correlation function integrals, i.e. spatial integrals of the pair radial distribution functions (RDFs), are evaluated. A main challenge is that the total correlation function integrals do not converge within...... integration, while for small systems, it seems to be even better. The method is applied to compute the excess Gibbs energy of the mixtures of water and organic solvents used in the simulations of CALB. This allows to determine the water activity of the simulated systems and thus to compare protein properties...

  18. Dissociation of a strong acid in neat solvents: diffusion is observed after reversible proton ejection inside the solvent shell.

    Science.gov (United States)

    Veiga-Gutiérrez, Manoel; Brenlla, Alfonso; Carreira Blanco, Carlos; Fernández, Berta; Kovalenko, Sergey A; Rodríguez-Prieto, Flor; Mosquera, Manuel; Lustres, J Luis Pérez

    2013-11-14

    Strong-acid dissociation was studied in alcohols. Optical excitation of the cationic photoacid N-methyl-6-hydroxyquinolinium triggers proton transfer to the solvent, which was probed by spectral reconstruction of picosecond fluorescence traces. The process fulfills the classical Eigen-Weller mechanism in two stages: (a) solvent-controlled reversible dissociation inside the solvent shell and (b) barrierless splitting of the encounter complex. This can be appreciated only when fluorescence band integrals are used to monitor the time evolution of the reactant and product concentrations. Band integrals are insensitive to solvent dynamics and report relative concentrations directly. This was demonstrated by first measuring the fluorescence decay of the conjugate base across the full emission band, independently of the proton-transfer reaction. Multiexponential decay curves at single wavelengths result from a dynamic red shift of fluorescence in the course of solvent relaxation, whereas clean single exponential decays are obtained if the band integral is monitored instead. The extent of the shift is consistent with previously reported femtosecond transient absorption measurements, continuum theory of solvatochromism, and molecular properties derived from quantum chemical calculations. In turn, band integrals show clean biexponential decay of the photoacid and triexponential evolution of the conjugate base in the course of the proton transfer to solvent reaction. The dissociation step follows the slowest stage of solvation, which was measured here independently by picosecond fluorescence spectroscopy in five aliphatic alcohols. Also, the rate constant of the encounter-complex splitting stage is compatible with proton diffusion. Thus, for this photoacid, both stages reach the highest possible rates: solvation and diffusion control. Under these conditions, the concentration of the encounter complex is substantial during the earliest nanosecond.

  19. Solvent/Non-Solvent Sintering To Make Microsphere Scaffolds

    Science.gov (United States)

    Laurencin, Cato T.; Brown, Justin L.; Nair, Lakshmi

    2011-01-01

    A solvent/non-solvent sintering technique has been devised for joining polymeric microspheres to make porous matrices for use as drug-delivery devices or scaffolds that could be seeded with cells for growing tissues. Unlike traditional sintering at elevated temperature and pressure, this technique is practiced at room temperature and pressure and, therefore, does not cause thermal degradation of any drug, protein, or other biochemical with which the microspheres might be loaded to impart properties desired in a specific application. Also, properties of scaffolds made by this technique are more reproducible than are properties of comparable scaffolds made by traditional sintering. The technique involves the use of two miscible organic liquids: one that is and one that is not a solvent for the affected polymer. The polymeric microspheres are placed in a mold having the size and shape of the desired scaffold, then the solvent/non-solvent mixture is poured into the mold to fill the void volume between the microspheres, then the liquid mixture is allowed to evaporate. Some of the properties of the resulting scaffold can be tailored through choice of the proportions of the liquids and the diameter of the microspheres.

  20. The outcome of interprofessional education: Integrating communication studies into a standardized patient experience for advanced practice nursing students.

    Science.gov (United States)

    Defenbaugh, Nicole; Chikotas, Noreen E

    2016-01-01

    The purpose of this qualitative study was to examine the impact of standardized patient experiences (SPE) in the education of the Advanced Practice Nurse (APN). The education of the APN requires educators to make every attempt to promote competency in the areas of communication and clinical-decision making. SPE programs have been found to improve the interpersonal, problem solving, and critical thinking skills of nursing students. For this research twenty-nine APN students participated in SPEs over the course of two semesters. Fifteen student volunteers of those 29 participants were then interviewed three months after the experience. Results revealed that having an expert in the field of communication studies increased awareness of communication skills and how to improve nurse-patient encounters in the clinical setting. The interprofessional collaboration during the SPEs assisted in facilitating the application of learned communication skills into patient-centered care of the APN student.

  1. Next generation bioelectronics: Advances in fabrication coupled with clever chemistries enable the effective integration of biomaterials and organic conductors

    Science.gov (United States)

    Molino, Paul J.; Wallace, Gordon G.

    2015-01-01

    Organic bioelectronics is making an enormous impact in the field of tissue engineering, providing not just biocompatible, but biofunctional conducting material platforms. For their true potential to be reached, it is critical to integrate organic conductors with other biopolymers in a targeted manner, allowing the development of devices and scaffold architectures capable of delivering a number of physical, chemical, and electrical stimuli. Herein, we provide an overview of the methods currently being employed to tailor organic conductors for bioapplications, with a focus on the development of fabrication techniques vital to the development of the next generation of intelligent bionic devices.

  2. Next generation bioelectronics: Advances in fabrication coupled with clever chemistries enable the effective integration of biomaterials and organic conductors

    Directory of Open Access Journals (Sweden)

    Paul J. Molino

    2015-01-01

    Full Text Available Organic bioelectronics is making an enormous impact in the field of tissue engineering, providing not just biocompatible, but biofunctional conducting material platforms. For their true potential to be reached, it is critical to integrate organic conductors with other biopolymers in a targeted manner, allowing the development of devices and scaffold architectures capable of delivering a number of physical, chemical, and electrical stimuli. Herein, we provide an overview of the methods currently being employed to tailor organic conductors for bioapplications, with a focus on the development of fabrication techniques vital to the development of the next generation of intelligent bionic devices.

  3. Advances in Integrating Traditional and Omic Biomarkers When Analyzing the Effects of the Mediterranean Diet Intervention in Cardiovascular Prevention

    Science.gov (United States)

    Fitó, Montserrat; Melander, Olle; Martínez, José Alfredo; Toledo, Estefanía; Carpéné, Christian; Corella, Dolores

    2016-01-01

    Intervention with Mediterranean diet (MedDiet) has provided a high level of evidence in primary prevention of cardiovascular events. Besides enhancing protection from classical risk factors, an improvement has also been described in a number of non-classical ones. Benefits have been reported on biomarkers of oxidation, inflammation, cellular adhesion, adipokine production, and pro-thrombotic state. Although the benefits of the MedDiet have been attributed to its richness in antioxidants, the mechanisms by which it exercises its beneficial effects are not well known. It is thought that the integration of omics including genomics, transcriptomics, epigenomics, and metabolomics, into studies analyzing nutrition and cardiovascular diseases will provide new clues regarding these mechanisms. However, omics integration is still in its infancy. Currently, some single-omics analyses have provided valuable data, mostly in the field of genomics. Thus, several gene-diet interactions in determining both intermediate (plasma lipids, etc.) and final cardiovascular phenotypes (stroke, myocardial infarction, etc.) have been reported. However, few studies have analyzed changes in gene expression and, moreover very few have focused on epigenomic or metabolomic biomarkers related to the MedDiet. Nevertheless, these preliminary results can help to better understand the inter-individual differences in cardiovascular risk and dietary response for further applications in personalized nutrition. PMID:27598147

  4. Damage assessment using advanced non-intrusive inspection methods: integration of space, UAV, GPR, and field spectroscopy

    Science.gov (United States)

    Themistocleous, Kyriacos; Neocleous, Kyriacos; Pilakoutas, Kypros; Hadjimitsis, Diofantos G.

    2014-08-01

    The predominant approach for conducting road condition surveys and analyses is still largely based on extensive field observations. However, visual assessment alone cannot identify the actual extent and severity of damage. New non-invasive and cost-effective non-destructive (NDT) remote sensing technologies can be used to monitor road pavements across their life cycle, including remotely sensed aerial and satellite visual and thermal image (AI) data, Unmanned Aerial Vehicles (UAVs), Spectroscopy and Ground Penetrating Radar (GRP). These non-contact techniques can be used to obtain surface and sub-surface information about damage in road pavements, including the crack depth, and in-depth structural failure. Thus, a smart and cost-effective methodology is required that integrates several of these non-destructive/ no-contact techniques for the damage assessment and monitoring at different levels. This paper presents an overview of how an integration of the above technologies can be used to conduct detailed road condition surveys. The proposed approach can also be used to predict the future needs for road maintenance; this information is proven to be valuable to a strategic decision making tools that optimizes maintenance based on resources and environmental issues.

  5. Integration of an advanced sealed-tube neutron generator into a mobile neutron radiology system and resulting performance

    Science.gov (United States)

    Dance, William E.; Cluzeau, Serge; Mast, Hans-Ulrich

    1991-05-01

    The first DIANE ∗ neutron radiology system is being prepared for operation in the IABG laboratories in Ottobrunn (Germany). It utilizes a new D-T generator, designated GENIE 46, developed by SODERN (France) for this application. The generator is being integrated into an upgraded LTV-produced mobile neutron radiology system suitable for practical nonreactor inspection of components and structures. The maximum output of the present version of the GENIE 46 is 5 × 10 11 n s -1 (14 MeV) with less than 10 mA ion beam current at 225 kV. Tube lifetime at maximum output is approximately 500 h, while at 10 11 n s -1 the tube is designed for a lifetime of 1500 h. The geometry of the neutron tube, VHV connectors, ion source power supply, and cooling tubes comprises a cannister designed to be compatible with the 10-in. diameter opening in the LTV moderator/collimator assembly. 3-D Monte Carlo neutron/photon transport simulations of the new integrated radiology system operation have been performed by IABG. The calculations predict a thermal neutron flux at the collimator exit ( {L}/{D} = 13) of φth(0 ≤ En ≤ 0.3 eV) = 1.2 × 10 5 n cm -2 s -1. Comparisons of this value and other Monte Carlo results with actual performance will be made in the near future with the accrual of operational data.

  6. Advances in Integrating Traditional and Omic Biomarkers When Analyzing the Effects of the Mediterranean Diet Intervention in Cardiovascular Prevention.

    Science.gov (United States)

    Fitó, Montserrat; Melander, Olle; Martínez, José Alfredo; Toledo, Estefanía; Carpéné, Christian; Corella, Dolores

    2016-09-02

    Intervention with Mediterranean diet (MedDiet) has provided a high level of evidence in primary prevention of cardiovascular events. Besides enhancing protection from classical risk factors, an improvement has also been described in a number of non-classical ones. Benefits have been reported on biomarkers of oxidation, inflammation, cellular adhesion, adipokine production, and pro-thrombotic state. Although the benefits of the MedDiet have been attributed to its richness in antioxidants, the mechanisms by which it exercises its beneficial effects are not well known. It is thought that the integration of omics including genomics, transcriptomics, epigenomics, and metabolomics, into studies analyzing nutrition and cardiovascular diseases will provide new clues regarding these mechanisms. However, omics integration is still in its infancy. Currently, some single-omics analyses have provided valuable data, mostly in the field of genomics. Thus, several gene-diet interactions in determining both intermediate (plasma lipids, etc.) and final cardiovascular phenotypes (stroke, myocardial infarction, etc.) have been reported. However, few studies have analyzed changes in gene expression and, moreover very few have focused on epigenomic or metabolomic biomarkers related to the MedDiet. Nevertheless, these preliminary results can help to better understand the inter-individual differences in cardiovascular risk and dietary response for further applications in personalized nutrition.

  7. Advances in Integrating Traditional and Omic Biomarkers When Analyzing the Effects of the Mediterranean Diet Intervention in Cardiovascular Prevention

    Directory of Open Access Journals (Sweden)

    Montserrat Fitó

    2016-09-01

    Full Text Available Intervention with Mediterranean diet (MedDiet has provided a high level of evidence in primary prevention of cardiovascular events. Besides enhancing protection from classical risk factors, an improvement has also been described in a number of non-classical ones. Benefits have been reported on biomarkers of oxidation, inflammation, cellular adhesion, adipokine production, and pro-thrombotic state. Although the benefits of the MedDiet have been attributed to its richness in antioxidants, the mechanisms by which it exercises its beneficial effects are not well known. It is thought that the integration of omics including genomics, transcriptomics, epigenomics, and metabolomics, into studies analyzing nutrition and cardiovascular diseases will provide new clues regarding these mechanisms. However, omics integration is still in its infancy. Currently, some single-omics analyses have provided valuable data, mostly in the field of genomics. Thus, several gene-diet interactions in determining both intermediate (plasma lipids, etc. and final cardiovascular phenotypes (stroke, myocardial infarction, etc. have been reported. However, few studies have analyzed changes in gene expression and, moreover very few have focused on epigenomic or metabolomic biomarkers related to the MedDiet. Nevertheless, these preliminary results can help to better understand the inter-individual differences in cardiovascular risk and dietary response for further applications in personalized nutrition.

  8. Security-Oriented and Load-Balancing Wireless Data Routing Game in the Integration of Advanced Metering Infrastructure Network in Smart Grid

    Energy Technology Data Exchange (ETDEWEB)

    He, Fulin; Cao, Yang; Zhang, Jun Jason; Wei, Jiaolong; Zhang, Yingchen; Muljadi, Eduard; Gao, Wenzhong

    2016-11-21

    Ensuring flexible and reliable data routing is indispensable for the integration of Advanced Metering Infrastructure (AMI) networks, we propose a secure-oriented and load-balancing wireless data routing scheme. A novel utility function is designed based on security routing scheme. Then, we model the interactive security-oriented routing strategy among meter data concentrators or smart grid meters as a mixed-strategy network formation game. Finally, such problem results in a stable probabilistic routing scheme with proposed distributed learning algorithm. One contributions is that we studied that different types of applications affect the routing selection strategy and the strategy tendency. Another contributions is that the chosen strategy of our mixed routing can adaptively to converge to a new mixed strategy Nash equilibrium (MSNE) during the learning process in the smart grid.

  9. Handbook of green chemistry, green solvents, supercritical solvents

    CERN Document Server

    Anastas, Paul T; Jessop, Philip G

    2014-01-01

    Green Chemistry is a vitally important subject area in a world where being as green and environmentally sound as possible is no longer a luxury but a necessity. Its applications include the design of chemical products and processes that help to reduce or eliminate the use and generation of hazardous substances. The Handbook of Green Chemistry comprises 12 volumes, split into subject-specific sets as follows: Set I: Green Catalysis Set II: Green Solvents Volume 4: Supercritical Solvents Volume 5: Reactions in Water Volume 6: Ionic Liquids

  10. DOE solvent handbook information sheet

    Energy Technology Data Exchange (ETDEWEB)

    Chavez, A.A.

    1992-01-01

    Solvents and cleaners are used in the Department of Defense (DOD) and the Department of Energy-Defense Program (DOE-DP) maintenance facilities for removing wax, grease, oil, carbon, machining fluids, solder fluxes, mold releases, and other contaminants before repairing or electroplating parts. Private industry also uses cleaners and degreasers for surface preparation of various metals. Growing environmental and worker safety concerns have brought attention to these solvents and cleaners, most of which are classified as toxic. Tightening government regulations have already excluded the use of some chemicals, and restrict the use of various halogenated hydrocarbons because of their atmospheric-ozone depleting effects, as well as their cancer-related risks. As a result, a program was established to develop an efficient, easily accessible, electronic solvent utilization handbook. This is being accomplished by: (1) identifying solvents (alternatives) that are not currently restricted by government regulations for use DOE-DP facilities, and private industry, (2) evaluating their cleaning performance, (3) evaluating their corrosivity, (4) evaluating their air emissions, (5) evaluating the possibility of recycling or recovering all or portions of the alternative degreasers, (6) testing substitute solvents compatibility with non-metallic materials, (7) inputting all of the data gathered (including previous biodegradability information) into a database, and (8) developing a methodology for efficient, widespread access to the data base information system.

  11. DOE solvent handbook information sheet

    Energy Technology Data Exchange (ETDEWEB)

    Chavez, A.A.

    1992-05-01

    Solvents and cleaners are used in the Department of Defense (DOD) and the Department of Energy-Defense Program (DOE-DP) maintenance facilities for removing wax, grease, oil, carbon, machining fluids, solder fluxes, mold releases, and other contaminants before repairing or electroplating parts. Private industry also uses cleaners and degreasers for surface preparation of various metals. Growing environmental and worker safety concerns have brought attention to these solvents and cleaners, most of which are classified as toxic. Tightening government regulations have already excluded the use of some chemicals, and restrict the use of various halogenated hydrocarbons because of their atmospheric-ozone depleting effects, as well as their cancer-related risks. As a result, a program was established to develop an efficient, easily accessible, electronic solvent utilization handbook. This is being accomplished by: (1) identifying solvents (alternatives) that are not currently restricted by government regulations for use DOE-DP facilities, and private industry, (2) evaluating their cleaning performance, (3) evaluating their corrosivity, (4) evaluating their air emissions, (5) evaluating the possibility of recycling or recovering all or portions of the alternative degreasers, (6) testing substitute solvents compatibility with non-metallic materials, (7) inputting all of the data gathered (including previous biodegradability information) into a database, and (8) developing a methodology for efficient, widespread access to the data base information system.

  12. A protocol for an exploratory phase I mixed-methods study of enhanced integrated care for care home residents with advanced dementia: the Compassion Intervention

    Science.gov (United States)

    Elliott, Margaret; Harrington, Jane; Moore, Kirsten; Davis, Sarah; Kupeli, Nuriye; Vickerstaff, Victoria; Gola, Anna; Candy, Bridget; Sampson, Elizabeth L; Jones, Louise

    2014-01-01

    Introduction In the UK approximately 700 000 people are living with, and a third of people aged over 65 will die with, dementia. People with dementia may receive poor quality care towards the end of life. We applied a realist approach and used mixed methods to develop a complex intervention to improve care for people with advanced dementia and their family carers. Consensus on intervention content was achieved using the RAND UCLA appropriateness method and mapped to sociological theories of process and impact. Core components are: (1) facilitation of integrated care, (2) education, training and support, (3) investment from commissioners and care providers. We present the protocol for an exploratory phase I study to implement components 1 and 2 in order to understand how the intervention operates in practice and to assess feasibility and acceptability. Methods and analysis An ‘Interdisciplinary Care Leader (ICL)’ will work within two care homes, alongside staff and associated professionals to facilitate service integration, encourage structured needs assessment, develop the use of personal and advance care plans and support staff training. We will use qualitative and quantitative methods to collect data for a range of outcome and process measures to detect effects on individual residents, family carers, care home staff, the intervention team, the interdisciplinary team and wider systems. Analysis will include descriptive statistics summarising process and care home level data, individual demographic and clinical characteristics and data on symptom burden, clinical events and quality of care. Qualitative data will be explored using thematic analysis. Findings will inform a future phase II trial. Ethics and dissemination Ethical approval was granted (REC reference 14/LO/0370). We shall publish findings at conferences, in peer-reviewed journals, on the Marie Curie Cancer Care website and prepare reports for dissemination by organisations involved with end

  13. Integrated biorefinery concept for grass silage using a combination of adapted pulping methods for advanced saccharification and extraction of lignin.

    Science.gov (United States)

    Schwarz, Dominik; Dörrstein, Jörg; Kugler, Sabine; Schieder, Doris; Zollfrank, Cordt; Sieber, Volker

    2016-09-01

    An integrated refining and pulping process for ensiled biomass from permanent grassland was established on laboratory scale. The liquid phase, containing the majority of water-soluble components, including 24% of the initial dry matter (DM), was first separated by mechanical pressing. The fiber fraction was subjected to high solid load saccharification (25% DM) to enhance the lignin content in the feed for subsequent organosolvation. The saccharification enzymes were pre-selected applying experimental design approaches. Cellulose convertibility was improved by a secondary pressing step during liquefaction. Combined saccharification and organosolvation showed high degree of saccharide solubilization with recovery of 98% of the glucan and 73% of the xylan from the fiber fraction in the hydrolysates, and enabled the recovery of 41% of the grass silage lignin. The effects of the treatment were confirmed by XRD and SEM tracking of cellulose crystallinity and fiber morphology throughout the pulping procedure.

  14. The use of regional advance mitigation planning (RAMP) to integrate transportation infrastructure impacts with sustainability; a perspective from the USA

    Science.gov (United States)

    Thorne, James H.; Huber, Patrick R.; O'Donoghue, Elizabeth; Santos, Maria J.

    2014-05-01

    Globally, urban areas are expanding, and their regional, spatially cumulative, environmental impacts from transportation projects are not typically assessed. However, incorporation of a Regional Advance Mitigation Planning (RAMP) framework can promote more effective, ecologically sound, and less expensive environmental mitigation. As a demonstration of the first phase of the RAMP framework, we assessed environmental impacts from 181 planned transportation projects in the 19 368 km2 San Francisco Bay Area. We found that 107 road and railroad projects will impact 2411-3490 ha of habitat supporting 30-43 threatened or endangered species. In addition, 1175 ha of impacts to agriculture and native vegetation are expected, as well as 125 crossings of waterways supporting anadromous fish species. The extent of these spatially cumulative impacts shows the need for a regional approach to associated environmental offsets. Many of the impacts were comprised of numerous small projects, where project-by-project mitigation would result in increased transaction costs, land costs, and lost project time. Ecological gains can be made if a regional approach is taken through the avoidance of small-sized reserves and the ability to target parcels for acquisition that fit within conservation planning designs. The methods are straightforward, and can be used in other metropolitan areas.

  15. Solvent Extraction in Hydrometallurgy: Present and Future

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    During the past 10 years, there have been incremental advances in the application of solvent extraction to process hydrometallurgy. The most cited areas in the literature include chemistry, chemical engineering, pilot plants, and plant operation. Within these areas, there were considerable interest in synergism,diluents, degradation, contactors, surfactants, hydrometallurgical applications, environmental and secondary applications, and health and safety. The summary to the present is followed by a prediction for the future in the above areas of interest. These include the use of speciation; improved understanding of the role of surfactants on the system; optimization through modelling, pilot plants, and contactor selection; improvements in plant operation; further new applications; and plant safety. The review has indicated that considerable knowledge is now available to optimize and improve on process design and plant applications.

  16. Multiple sclerosis and organic solvents

    DEFF Research Database (Denmark)

    Mortensen, J T; Brønnum-Hansen, Henrik; Rasmussen, K

    1998-01-01

    We investigated a possible causal relation between exposure to organic solvents in Danish workers (housepainters, typographers/printers, carpenters/cabinetmakers) and onset of multiple sclerosis. Data on men included in the Danish Multiple Sclerosis Register (3,241 men) were linked with data from......, and butchers. Over a follow-up period of 20 years, we observed no increase in the incidence of multiple sclerosis among men presumed to be exposed to organic solvents. It was not possible to obtain data on potential confounders, and the study design has some potential for selection bias. Nevertheless......, the study does not support existing hypotheses regarding an association between occupational exposure to organic solvents and multiple sclerosis....

  17. Memory-related white matter tract integrity in amyotrophic lateral sclerosis: an advanced neuroimaging and neuropsychological study.

    Science.gov (United States)

    Christidi, Foteini; Karavasilis, Efstratios; Zalonis, Ioannis; Ferentinos, Panagiotis; Giavri, Zoi; Wilde, Elisabeth A; Xirou, Sophia; Rentzos, Michalis; Zouvelou, Vasiliki; Velonakis, George; Toulas, Panagiotis; Efstathopoulos, Efstathios; Poulou, Loukia; Argyropoulos, Georgios; Athanasakos, Athanasios; Zambelis, Thomas; Levin, Harvey S; Karandreas, Nikolaos; Kelekis, Nikolaos; Evdokimidis, Ioannis

    2017-01-01

    We aimed to investigate structural changes in vivo in memory-related white matter tracts (i.e., perforant pathway zone [PPZ]; uncinate fasciculus [UF]; fornix) using diffusion tensor tractography and evaluate possible associations with memory performance in nondemented patients with amyotrophic lateral sclerosis (ALS). Forty-two ALS patients and 25 healthy controls (HCs) underwent a 30-directional diffusion-weighted imaging on a 3T MR scanner, followed by tractography of PPZ, UF, and fornix and analysis of fractional anisotropy (FA), axial diffusivity and radial diffusivity (Dr). Patients were administered neuropsychological measures of verbal (list learning via Rey Auditory Verbal Learning Test [RAVLT] and prose memory via Babcock Story Recall Test) and nonverbal (Rey's Complex Figure Test) episodic memory. After correcting for multiple comparisons, ALS patients showed increased Dr in the left PPZ compared to HC. We then fitted a multivariate general linear model within ALS patients with neuropsychological measures as dependent variables and age, age(2), gender, verbal IQ, and diffusion tensor tractography metrics with at least medium effect size differences between ALS and HC as independent variables. We found that (1) left PPZ FA, gender, and verbal IQ contributed to RAVLT-Total Learning; (2) left PPZ FA, left UF Dr, and gender contributed to RAVLT-Immediate Recall; and (3) left PPZ FA and left UF axial diffusivity contributed to Babcock Story Recall Test-Immediate and Delayed Recall. Advanced neuroimaging techniques verified in this study previously reported neuropathological findings regarding PPZ degeneration in ALS. We also detected a unique contribution of microstructural changes in hippocampal and frontotemporal white matter tracts on patients' memory profile.

  18. Development of ITM Oxygen Technology for Integration in IGCC and Other Advanced Power Generation DECISION POINT 1 UNDER PHASE 3

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, Lori

    2013-08-01

    Air Products and the DOE have partnered over a number of years in the development of ITM Oxygen technology in support of gasification technology. Throughout this process, studies of application of the technology to IGCC and oxy-coal combustion have shown significant reduction in capital and operating costs compared to similar systems using conventional cryogenic air separation. Phase 3, the current phase of the program, focuses on the design, construction and operation of a 30- to 100-TPD pilot facility, the Intermediate Scale Test Unit (ISTU). Execution of this phase to date has resulted in significant advances in a number of areas including ceramic membrane material development, module design and production, ceramic-to-metal seal design, process control strategies, and engineering development of process cycles. Phase 3 will be complete upon successful operation of the ISTU in a series of tests making oxygen from ceramic membrane modules and producing power from a hot gas expander. Phase 3 work has extended beyond the planned schedule due to a delay in delivery of equipment from vendors. Air Products is currently managing the equipment delay by close involvement with the vendor to redesign the problematic equipment and oversee its fabrication. The result of these unforeseen challenges is that the ISTU project completion date has been delayed. Tight cost controls have been implemented both by DOE program management and APCI to meet budget constraints despite increased costs due to budget delays. Total project costs have increased in several areas. Increased costs in the ISTU project include purchased equipment, instruments, construction, and contractor engineering. Increased costs for other tasks include additional work in support of module production by Ceramatec, Inc, and increased Air Products labor for component testing. Air Products plans to complete testing as outlined in the SOPO and successfully complete all project objectives by the end of FY14.

  19. Advancing satellite-based solar power forecasting through integration of infrared channels for automatic detection of coastal marine inversion layer

    Energy Technology Data Exchange (ETDEWEB)

    Kostylev, Vladimir; Kostylev, Andrey; Carter, Chris; Mahoney, Chad; Pavlovski, Alexandre; Daye, Tony [Green Power Labs Inc., Dartmouth, NS (Canada); Cormier, Dallas Eugene; Fotland, Lena [San Diego Gas and Electric Co., San Diego, CA (United States)

    2012-07-01

    The marine atmospheric boundary layer is a layer or cool, moist maritime air with the thickness of a few thousand feet immediately below a temperature inversion. In coastal areas as moist air rises from the ocean surface, it becomes trapped and is often compressed into fog above which a layer of stratus clouds often forms. This phenomenon is common for satellite-based solar radiation monitoring and forecasting. Hour ahead satellite-based solar radiation forecasts are commonly using visible spectrum satellite images, from which it is difficult to automatically differentiate low stratus clouds and fog from high altitude clouds. This provides a challenge for cloud motion tyracking and cloud cover forecasting. San Diego Gas and Electric {sup registered} (SDG and E {sup registered}) Marine Layer Project was undertaken to obtain information for integration with PV forecasts, and to develop a detailed understanding of long-term benefits from forecasting Marine Layer (ML) events and their effects on PV production. In order to establish climatological ML patterns, spatial extent and distribution of marine layer, we analyzed visible and IR spectrum satellite images (GOES WEST) archive for the period of eleven years (2000 - 2010). Historical boundaries of marine layers impact were established based on the cross-classification of visible spectrum (VIS) and infrared (IR) images. This approach is successfully used by us and elsewhere for evaluating cloud albedo in common satellite-based techniques for solar radiation monitoring and forecasting. The approach allows differentiation of cloud cover and helps distinguish low laying fog which is the main consequence of marine layer formation. ML occurrence probability and maximum extent inland was established for each hour and day of the analyzed period and seasonal/patterns were described. SDG and E service area is the most affected region by ML events with highest extent and probability of ML occurrence. Influence of ML was the

  20. Simultaneous Integrated Boost Using Intensity-Modulated Radiotherapy Compared With Conventional Radiotherapy in Patients Treated With Concurrent Carboplatin and 5-Fluorouracil for Locally Advanced Oropharyngeal Carcinoma

    Energy Technology Data Exchange (ETDEWEB)

    Clavel, Sebastien, E-mail: sebastien.clavel@umontreal.ca [Department of Radiation Oncology, Centre Hospitalier de l' Universite de Montreal, Montreal, QC (Canada); Nguyen, David H.A.; Fortin, Bernard [Department of Radiation Oncology, Hopital Maisonneuve-Rosemont, Montreal, QC (Canada); Despres, Philippe [Department of Radiation Oncology, Centre Hospitalier de l' Universite de Montreal, Montreal, QC (Canada); Khaouam, Nader [Department of Radiation Oncology, Hopital Maisonneuve-Rosemont, Montreal, QC (Canada); Donath, David [Department of Radiation Oncology, Centre Hospitalier de l' Universite de Montreal, Montreal, QC (Canada); Soulieres, Denis [Department of Medical Oncology, Centre Hospitalier de l' Universite de Montreal, Montreal, QC (Canada); Guertin, Louis [Department of Head and Neck Surgery, Centre Hospitalier de l' Universite de Montreal, Montreal, QC (Canada); Nguyen-Tan, Phuc Felix [Department of Radiation Oncology, Hopital Maisonneuve-Rosemont, Montreal, QC (Canada)

    2012-02-01

    Purpose: To compare, in a retrospective study, the toxicity and efficacy of simultaneous integrated boost using intensity-modulated radiotherapy (IMRT) vs. conventional radiotherapy (CRT) in patients treated with concomitant carboplatin and 5-fluorouracil for locally advanced oropharyngeal cancer. Methods and Materials: Between January 2000 and December 2007, 249 patients were treated with definitive chemoradiation. One hundred patients had 70 Gy in 33 fractions using IMRT, and 149 received CRT at 70 Gy in 35 fractions. Overall survival, disease-free survival, and locoregional control were estimated using the Kaplan-Meier method. Results: Median follow-up was 42 months. Three-year actuarial rates for locoregional control, disease-free survival, and overall survival were 95.1% vs. 84.4% (p = 0.005), 85.3% vs. 69.3% (p = 0.001), and 92.1% vs. 75.2% (p < 0.001) for IMRT and CRT, respectively. The benefit of the radiotherapy regimen on outcomes was also observed with a Cox multivariate analysis. Intensity-modulated radiotherapy was associated with less acute dermatitis and less xerostomia at 6, 12, 24, and 36 months. Conclusions: This study suggests that simultaneous integrated boost using IMRT is associated with favorable locoregional control and survival rates with less xerostomia and acute dermatitis than CRT when both are given concurrently with chemotherapy.

  1. Summary Describing Integration of ERM Methodology into Supervisory Control Framework with Software Package Documentation; Advanced Reactor Technology Milestone: M4AT-16PN2301052

    Energy Technology Data Exchange (ETDEWEB)

    Ramuhalli, Pradeep [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Hirt, Evelyn H. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Dib, Gerges [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Veeramany, Arun [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Bonebrake, Christopher A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Roy, Surajit [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

    2016-09-20

    This project involved the development of enhanced risk monitors (ERMs) for active components in Advanced Reactor (AdvRx) designs by integrating real-time information about equipment condition with risk monitors. Health monitoring techniques in combination with predictive estimates of component failure based on condition and risk monitors can serve to indicate the risk posed by continued operation in the presence of detected degradation. This combination of predictive health monitoring based on equipment condition assessment and risk monitors can also enable optimization of maintenance scheduling with respect to the economics of plant operation. This report summarizes PNNL’s multi-year project on the development and evaluation of an ERM concept for active components while highlighting FY2016 accomplishments. Specifically, this report provides a status summary of the integration and demonstration of the prototypic ERM framework with the plant supervisory control algorithms being developed at Oak Ridge National Laboratory (ORNL), and describes additional case studies conducted to assess sensitivity of the technology to different quantities. Supporting documentation on the software package to be provided to ONRL is incorporated in this report.

  2. Advancing medical education: connecting interprofessional collaboration and education opportunities with integrative medicine initiatives to build shared learning.

    Science.gov (United States)

    Templeman, Kate; Robinson, Anske; McKenna, Lisa

    2016-12-01

    BackgroundImproved teamwork between conventional and complementary medicine (CM) practitioners is indicated to achieve effective healthcare. However, little is known about interprofessional collaboration and education in the context of integrative medicine (IM). MethodsThis paper reports the findings from a constructivist-grounded theory method study that explored and highlighted Australian medical students' experiences and opportunities for linking interprofessional collaboration and learning in the context of IM. Following ethical approval, in-depth semi-structured interviews were conducted with 30 medical students from 10 medical education faculties across Australian universities. Results Medical students recognised the importance of interprofessional teamwork between general medical practitioners and CM professionals in patient care and described perspectives of shared responsibilities, profession-specific responsibilities, and collaborative approaches within IM. While students identified that limited interprofessional collaboration currently occurred in the medical curriculum, interprofessional education was considered a means of increasing communication and collaboration between healthcare professionals, helping coordinate effective patient care, and understanding each healthcare team members' professional role and value. Conclusions The findings suggest that medical curricula should include opportunities for medical students to develop required skills, behaviours, and attitudes for interprofessional collaboration and interprofessional education within the context of IM. While this is a qualitative study that reflects theoretical saturation from a selected cohort of medical students, the results also point to the importance of including CM professionals within interprofessional collaboration, thus contributing to more person-centred care.

  3. Development of design technology for system - integrated modular advanced react or (SMART) /technology support of NSSS design for SMART

    Energy Technology Data Exchange (ETDEWEB)

    Joon, Hah Yung; Kim, Kee Eun [KOPEC, Taejeon (Korea)

    2002-03-01

    SMART design concept is very different from that of the commercial PWRs, as the main components such as the steam generator, pressurizer, and the main coolant pumps are incorporate the related sub-part systems into the reactor vessel. In this report the design for SMART is the basic design stage and is the new design technology development task for the first trial in Korea. KOPEC NED has participated with Korea Atomic Energy Research Institute for the task of 'Development of Design Technology for SMART' as supporting sub-task of it. The system design (ECCS, Makeup and Purification System), mechanical design (Seismic Analysis, BLPB Analysis, Structural Analysis, Design Load Calculation, Stress Fatigue Evaluation, Fracture Mechanical and Structural Integrity Evaluation), MMIS design (Alarm and Indication System, Information Processing System, Large Display Panel, Human System Interface Guideline) have been performed as a basic design for SMART during 31 months (1999. 9.1{approx}2002.3.31). This report is the final one for the support of the main task of Korea Atomic Energy Research Institute. 124 refs., 154 figs., 97 tabs. (Author)

  4. Recent Advances and Field Trial Results Integrating Cosmic Ray Muon Tomography with Other Data Sources for Mineral Exploration

    Science.gov (United States)

    Schouten, D.

    2015-12-01

    CRM GeoTomography Technologies, Inc. is leading the way in applying muon tomography to discovery and definition of dense ore bodies for mineral exploration and resource estimation. We have successfully imaged volcanogenic massive sulfide (VMS) deposits at mines in North America using our suite of field-proven muon tracking detectors, and are at various stages of development for other applications. Recently we developed in-house inversion software that integrates data from assays, surface and borehole gravity, and underground muon flux measurements. We have found that the differing geophysical data sources provide complementary information and that dramatic improvements in inversion results are attained using various inversion performance metrics related to the excess tonnage of the mineral deposits, as well as their spatial extents and locations. This presentation will outline field tests of muon tomography performed by CRM Geotomography in some real world examples, and will demonstrate the effectiveness of joint muon tomography, assay and gravity inversion techniques in field tests (where data are available) and in simulations.

  5. Application of Spatial Data Modeling Systems, Geographical Information Systems (GIS), and Transportation Routing Optimization Methods for Evaluating Integrated Deployment of Interim Spent Fuel Storage Installations and Advanced Nuclear Plants

    Energy Technology Data Exchange (ETDEWEB)

    Mays, Gary T [ORNL; Belles, Randy [ORNL; Cetiner, Sacit M [ORNL; Howard, Rob L [ORNL; Liu, Cheng [ORNL; Mueller, Don [ORNL; Omitaomu, Olufemi A [ORNL; Peterson, Steven K [ORNL; Scaglione, John M [ORNL

    2012-06-01

    The objective of this siting study work is to support DOE in evaluating integrated advanced nuclear plant and ISFSI deployment options in the future. This study looks at several nuclear power plant growth scenarios that consider the locations of existing and planned commercial nuclear power plants integrated with the establishment of consolidated interim spent fuel storage installations (ISFSIs). This research project is aimed at providing methodologies, information, and insights that inform the process for determining and optimizing candidate areas for new advanced nuclear power generation plants and consolidated ISFSIs to meet projected US electric power demands for the future.

  6. Advances in understanding energy consumption behavior and the governance of its change - Outline of an integrated framework

    Directory of Open Access Journals (Sweden)

    Paul eBurger

    2015-06-01

    Full Text Available Transforming today’s energy systems in industrialized countries requires a substantial reduction of the total energy consumption at the individual level. Selected instruments have been found to be effective in changing people’s behavior in single domains. However, the so far weak success story on reducing overall energy consumption indicates that our understanding of the determining factors of individual energy consumption as well as of its change is far from being conclusive. Among others, the scientific state of the art is dominated by analyzing single domains of consumption and by neglecting embodied energy. It also displays strong disciplinary splits and the literature often fails to distinguish between explaining behavior and explaining change of behavior. Moreover, there are knowledge gaps regarding the legitimacy and effectiveness of the governance of individual consumption behavior and its change. Against this backdrop, the aim of this paper is to establish an integrated interdisciplinary framework that offers a systematic basis for linking the different aspects in research on energy related consumption behavior, thus paving the way for establishing a better evidence base to inform societal actions. The framework connects the three relevant analytical aspects of the topic in question: (1 It systematically and conceptually frames the objects, i.e. the energy consumption behavior and its change (explananda; (2 it structures the factors that potentially explain the energy consumption behavior and its change (explanantia; (3 it provides a differentiated understanding of change inducing interventions in terms of governance. Based on the existing states of the art approaches from different disciplines within the social sciences the proposed framework is supposed to guide interdisciplinary empirical research.

  7. Computer-aided tool for solvent selection in pharmaceutical processes: Solvent swap

    DEFF Research Database (Denmark)

    Papadakis, Emmanouil; K. Tula, Anjan; Gernaey, Krist V.;

    In the pharmaceutical processes, solvents have a multipurpose role since different solvents can be used in different stages (such as chemical reactions, separations and purification) in the multistage active pharmaceutical ingredients (APIs) production process. The solvent swap and selection task...

  8. Improved Purex solvent scrubbing methods

    Energy Technology Data Exchange (ETDEWEB)

    Mailen, J.C.; Tallent, O.K.

    1984-01-01

    Studies of hydrazine and hydroxylamine salts as solvent scrubbing agents that can be decomposed into gases are summarized. Results from testing of countercurrent scrubbers and solid sorber columns that produce lesser amounts of permanent salts are reported. The status of studies of the acid-degradation of paraffin diluent and the options for removal of long-chain organic acids is given.

  9. Which solvent for olfactory testing?

    Science.gov (United States)

    Philpott, C M; Goodenough, P C; Wolstenholme, C R; Murty, G E

    2004-12-01

    The physical properties of any carrier can deteriorate over time and thus alter the results in any olfactory test. The aim of this study was to evaluate clinically potential solvents as a clean odourless carrier for olfactory testing. Sweet almond oil, pure coconut oil, pure peach kernel oil, dipropylene glycol, monopropylene glycol, mineral oil and silicone oil were studied. The experimentation was conducted in two parts. First, an olfactory device was used to conduct air through the solvents on a weekly basis using a cohort of six volunteers to assess the perceived odour of each solvent at weekly intervals. Secondly a cross-reference test was performed using small bottled solutions of phenylethyl-alcohol and 1-butanol in 10-fold dilutions to compare any perceived difference in concentrations over a period of 8 weeks. We concluded that mineral oil is the most suitable carrier for the purpose of olfactory testing, possessing many desirable characteristics of an olfactory solvent, and that silicone oil may provide a suitable alternative for odorants with which it is miscible.

  10. Carbon dioxide-based supercritical fluids as IC manufacturing solvents

    Energy Technology Data Exchange (ETDEWEB)

    Rubin, J.B.; Davenhall, L.B.; Taylor, C.M.V.; Sivils, L.D.; Pierce, T.; Tiefert, K.

    1999-05-11

    The production of integrated circuits (IC's) involves a number of discrete steps which utilize hazardous or regulated solvents and generate large waste streams. ES&H considerations associated with these chemicals have prompted a search for alternative, more environmentally benign solvent systems. An emerging technology for conventional solvent replacement is the use of supercritical fluids based on carbon dioxide (CO{sub 2}). Research work, conducted at Los Alamos in conjunction with the Hewlett-Packard Company, has lead to the development of a CO{sub 2}-based supercritical fluid treatment system for the stripping of hard-baked photoresists. This treatment system, known as Supercritical CO{sub 2} Resist Remover, or CORR, uses a two-component solvent composed of a nonhazardous, non-regulated compound, dissolved in supercritical CO{sub 2}. The solvent/treatment system has been successfully tested on metallized Si wafers coated with negative and positive photoresist, the latter both before and after ion-implantation. A description of the experimental data will be presented. Based on the initial laboratory results, the project has progressed to the design and construction of prototype, single-wafer photoresist-stripping equipment. The integrated system involves a closed-loop, recirculating cycle which continuously cleans and regenerates the CO{sub 2}, recycles the dissolved solvent, and separates and concentrates the spent resist. The status of the current design and implementation strategy of a treatment system to existing IC fabrication facilities will be discussed. Additional remarks will be made on the use of a SCORR-type system for the cleaning of wafers prior to processing.

  11. Method for analyzing solvent extracted sponge core

    Energy Technology Data Exchange (ETDEWEB)

    Ellington, W.E.; Calkin, C.L.

    1988-11-22

    For use in solvent extracted sponge core measurements of the oil saturation of earth formations, a method is described for quantifying the volume of oil in the fluids resulting from such extraction. The method consists of: (a) separating the solvent/oil mixture from the water in the extracted fluids, (b) distilling at least a portion of the solvent from the solvent/oil mixture substantially without co-distillation or loss of the light hydrocarbons in the mixture, (c) determining the volume contribution of the solvent remaining in the mixture, and (d) determining the volume of oil removed from the sponge by substracting the determined remaining solvent volume.

  12. Radiation Chemistry of Advanced TALSPEAK Flowsheet

    Energy Technology Data Exchange (ETDEWEB)

    Mincher, Bruce; Peterman, Dean; Mcdowell, Rocklan; Olson, Lonnie; Lumetta, Gregg J.

    2013-08-28

    This report summarizes the results of initial experiments designed to understand the radiation chemistry of an Advanced TALSPEAK process for separating trivalent lanthanides form the actinides. Biphasic aerated samples were irradiated and then analyzed for post-irradiation constituent concentrations and solvent extraction distribution ratios. The effects of irradiation on the TALSPEAK and Advanced TALSPEAK solvents were similar, with very little degradation of the organic phase extractant. Decomposition products were detected, with a major product in common for both solvents. This product may be responsible for the slight increase in distribution ratios for Eu and Am with absorbed dose, however; separation factors were not greatly affected.

  13. Hypofractionated Image-Guided IMRT in Advanced Pancreatic Cancer With Simultaneous Integrated Boost to Infiltrated Vessels Concomitant With Capecitabine: A Phase I Study

    Energy Technology Data Exchange (ETDEWEB)

    Passoni, Paolo, E-mail: passoni.paolo@hsr.it [Department of Radiation Oncology, San Raffaele Scientific Institute, Milan (Italy); Reni, Michele [Department of Medical Oncology, San Raffaele Scientific Institute, Milan (Italy); Cattaneo, Giovanni M. [Department of Medical Physics, San Raffaele Scientific Institute, Milan (Italy); Slim, Najla [Department of Radiation Oncology, San Raffaele Scientific Institute, Milan (Italy); Cereda, Stefano [Department of Medical Oncology, San Raffaele Scientific Institute, Milan (Italy); Balzano, Gianpaolo; Castoldi, Renato [Department of Surgery, San Raffaele Scientific Institute, Milan (Italy); Longobardi, Barbara [Department of Medical Physics, San Raffaele Scientific Institute, Milan (Italy); Bettinardi, Valentino; Gianolli, Luigi [Department of Nuclear Medicine, San Raffaele Scientific Institute, Milan (Italy); Gusmini, Simone [Department of Radiology, San Raffaele Scientific Institute, Milan (Italy); Staudacher, Carlo [Department of Surgery, San Raffaele Scientific Institute, Milan (Italy); Calandrino, Riccardo [Department of Medical Physics, San Raffaele Scientific Institute, Milan (Italy); Di Muzio, Nadia [Department of Radiation Oncology, San Raffaele Scientific Institute, Milan (Italy)

    2013-12-01

    Purpose: To determine the maximum tolerated radiation dose (MTD) of an integrated boost to the tumor subvolume infiltrating vessels, delivered simultaneously with radical dose to the whole tumor and concomitant capecitabine in patients with pretreated advanced pancreatic adenocarcinoma. Methods and Materials: Patients with stage III or IV pancreatic adenocarcinoma without progressive disease after induction chemotherapy were eligible. Patients underwent simulated contrast-enhanced four-dimensional computed tomography and fluorodeoxyglucose-labeled positron emission tomography. Gross tumor volume 1 (GTV1), the tumor, and GTV2, the tumor subvolume 1 cm around the infiltrated vessels, were contoured. GTVs were fused to generate Internal Target Volume (ITV)1 and ITV2. Biological tumor volume (BTV) was fused with ITV1 to create the BTV+Internal Target Volume (ITV) 1. A margin of 5/5/7 mm (7 mm in cranium-caudal) was added to BTV+ITV1 and to ITV2 to create Planning Target Volume (PTV) 1 and PTV2, respectively. Radiation therapy was delivered with tomotherapy. PTV1 received a fixed dose of 44.25 Gy in 15 fractions, and PTV2 received a dose escalation from 48 to 58 Gy as simultaneous integrated boost (SIB) in consecutive groups of at least 3 patients. Concomitant chemotherapy was capecitabine, 1250 mg/m{sup 2} daily. Dose-limiting toxicity (DLT) was defined as any treatment-related G3 nonhematological or G4 hematological toxicity occurring during the treatment or within 90 days from its completion. Results: From June 2005 to February 2010, 25 patients were enrolled. The dose escalation on the SIB was stopped at 58 Gy without reaching the MTD. One patient in the 2{sup nd} dose level (50 Gy) had a DLT: G3 acute gastric ulcer. Three patients had G3 late adverse effects associated with gastric and/or duodenal mucosal damage. All patients received the planned dose of radiation. Conclusions: A dose of 44.25 Gy in 15 fractions to the whole tumor with an SIB of 58 Gy to small

  14. Simultaneous Integrated Boost–Intensity Modulated Radiation Therapy With Concomitant Capecitabine and Mitomycin C for Locally Advanced Anal Carcinoma: A Phase 1 Study

    Energy Technology Data Exchange (ETDEWEB)

    Deenen, Maarten J. [Division of Clinical Pharmacology, Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam (Netherlands); Dewit, Luc [Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam (Netherlands); Boot, Henk [Division of Gastroenterology and Hepatology, Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam (Netherlands); Beijnen, Jos H. [Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam (Netherlands); Faculty of Science, Department of Pharmaceutical Sciences, Division of Pharmaco-epidemiology and Clinical Pharmacology, Utrecht University, Utrecht (Netherlands); Schellens, Jan H.M. [Division of Clinical Pharmacology, Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam (Netherlands); Faculty of Science, Department of Pharmaceutical Sciences, Division of Pharmaco-epidemiology and Clinical Pharmacology, Utrecht University, Utrecht (Netherlands); Cats, Annemieke, E-mail: a.cats@nki.nl [Division of Gastroenterology and Hepatology, Department of Medical Oncology, The Netherlands Cancer Institute, Amsterdam (Netherlands)

    2013-04-01

    Purpose: Newer radiation techniques, and the application of continuous 5-FU exposure during radiation therapy using oral capecitabine may improve the treatment of anal cancer. This phase 1, dose-finding study assessed the feasibility and efficacy of simultaneous integrated boost–intensity modulated radiation therapy (SIB-IMRT) with concomitant capecitabine and mitomycin C in locally advanced anal cancer, including pharmacokinetic and pharmacogenetic analyses. Methods and Materials: Patients with locally advanced anal carcinoma were treated with SIB-IMRT in 33 daily fractions of 1.8 Gy to the primary tumor and macroscopically involved lymph nodes and 33 fractions of 1.5 Gy electively to the bilateral iliac and inguinal lymph node areas. Patients received a sequential radiation boost dose of 3 × 1.8 Gy on macroscopic residual tumor if this was still present in week 5 of treatment. Mitomycin C 10 mg/m{sup 2} (maximum 15 mg) was administered intravenously on day 1, and capecitabine was given orally in a dose-escalated fashion (500-825 mg/m{sup 2} b.i.d.) on irradiation days, until dose-limiting toxicity emerged in ≥2 of maximally 6 patients. An additional 8 patients were treated at the maximum tolerated dose (MTD). Results: A total of 18 patients were included. The MTD of capecitabine was determined to be 825 mg/m{sup 2} b.i.d. The predominant acute grade ≥3 toxicities included radiation dermatitis (50%), fatigue (22%), and pain (6%). Fifteen patients (83% [95%-CI: 66%-101%]) achieved a complete response, and 3 (17%) patients a partial response. With a median follow-up of 28 months, none of the complete responders, and 2 partial responders had relapsed. Conclusions: SIB-IMRT with concomitant single dose mitomycin C and capecitabine 825 mg/m{sup 2} b.i.d. on irradiation days resulted in an acceptable safety profile, and proved to be a tolerable and effective treatment regimen for locally advanced anal cancer.

  15. Nuclear Energy Advanced Modeling and Simulation Waste Integrated Performance and Safety Codes (NEAMS Waste IPSC) verification and validation plan. version 1.

    Energy Technology Data Exchange (ETDEWEB)

    Bartlett, Roscoe Ainsworth; Arguello, Jose Guadalupe, Jr.; Urbina, Angel; Bouchard, Julie F.; Edwards, Harold Carter; Freeze, Geoffrey A.; Knupp, Patrick Michael; Wang, Yifeng; Schultz, Peter Andrew; Howard, Robert (Oak Ridge National Laboratory, Oak Ridge, TN); McCornack, Marjorie Turner

    2011-01-01

    The objective of the U.S. Department of Energy Office of Nuclear Energy Advanced Modeling and Simulation Waste Integrated Performance and Safety Codes (NEAMS Waste IPSC) is to provide an integrated suite of computational modeling and simulation (M&S) capabilities to quantitatively assess the long-term performance of waste forms in the engineered and geologic environments of a radioactive-waste storage facility or disposal repository. To meet this objective, NEAMS Waste IPSC M&S capabilities will be applied to challenging spatial domains, temporal domains, multiphysics couplings, and multiscale couplings. A strategic verification and validation (V&V) goal is to establish evidence-based metrics for the level of confidence in M&S codes and capabilities. Because it is economically impractical to apply the maximum V&V rigor to each and every M&S capability, M&S capabilities will be ranked for their impact on the performance assessments of various components of the repository systems. Those M&S capabilities with greater impact will require a greater level of confidence and a correspondingly greater investment in V&V. This report includes five major components: (1) a background summary of the NEAMS Waste IPSC to emphasize M&S challenges; (2) the conceptual foundation for verification, validation, and confidence assessment of NEAMS Waste IPSC M&S capabilities; (3) specifications for the planned verification, validation, and confidence-assessment practices; (4) specifications for the planned evidence information management system; and (5) a path forward for the incremental implementation of this V&V plan.

  16. Steady state recycling chromatography with solvent removal-effect of solvent removal constraints on process operation under ideal conditions.

    Science.gov (United States)

    Siitonen, Jani; Sainio, Tuomo

    2014-05-09

    Steady state recycling chromatography (SSR) offers a means to reduce eluent consumption and increase productivity in preparative and production scale chromatographic separations. Even better performance is obtained with an integrated process by coupling solvent removal unit to the chromatographic separation unit. Here a design method for SSR with an integrated solvent removal unit (SSR-SR) is presented. The method is more practical than previous work as the effect of physical constraints, such as solubility or viscosity, imposed on the amount of solvent removed is included. The method holds under ideal conditions for binary systems with competitive Langmuir isotherm model. The design equations allow calculation of the regions of feasible operating parameters when either the maximum concentrations in the solvent removal unit or of the solution fed into the chromatographic column is restricted. The method was applied to analyze the performance of different SSR-SR configurations in two case studies: the separation of mandelic acid enantiomers and the separation of EMD 53986 enantiomers. The benefits of SSR-SR are relatively small under ideal conditions but the design method developed here can give a good starting point for designing SSR-SR processes under non-ideal conditions.

  17. The hype with ionic liquids as solvents

    Science.gov (United States)

    Kunz, Werner; Häckl, Katharina

    2016-09-01

    In this mini review, we give our personal opinion about the present state of the art concerning Ionic Liquids, proposed as alternative solvents. In particular, we consider their different drawbacks and disadvantages and discuss the critical aspects of the research of Ionic Liquids as solvents. Finally, we point out some aspects on potentially promising Ionic Liquid solvents.

  18. The solvent component of macromolecular crystals

    Energy Technology Data Exchange (ETDEWEB)

    Weichenberger, Christian X. [European Academy of Bozen/Bolzano (EURAC), Viale Druso 1, Bozen/Bolzano, I-39100 Südtirol/Alto Adige (Italy); Afonine, Pavel V. [Lawrence Berkeley National Laboratory (LBNL), 1 Cyclotron Road, Mail Stop 64R0121, Berkeley, CA 94720 (United States); Kantardjieff, Katherine [California State University, San Marcos, CA 92078 (United States); Rupp, Bernhard, E-mail: br@hofkristallamt.org [k.-k. Hofkristallamt, 991 Audrey Place, Vista, CA 92084 (United States); Medical University of Innsbruck, Schöpfstrasse 41, A-6020 Innsbruck (Austria)

    2015-04-30

    On average, the mother liquor or solvent and its constituents occupy about 50% of a macromolecular crystal. Ordered as well as disordered solvent components need to be accurately accounted for in modelling and refinement, often with considerable complexity. The mother liquor from which a biomolecular crystal is grown will contain water, buffer molecules, native ligands and cofactors, crystallization precipitants and additives, various metal ions, and often small-molecule ligands or inhibitors. On average, about half the volume of a biomolecular crystal consists of this mother liquor, whose components form the disordered bulk solvent. Its scattering contributions can be exploited in initial phasing and must be included in crystal structure refinement as a bulk-solvent model. Concomitantly, distinct electron density originating from ordered solvent components must be correctly identified and represented as part of the atomic crystal structure model. Herein, are reviewed (i) probabilistic bulk-solvent content estimates, (ii) the use of bulk-solvent density modification in phase improvement, (iii) bulk-solvent models and refinement of bulk-solvent contributions and (iv) modelling and validation of ordered solvent constituents. A brief summary is provided of current tools for bulk-solvent analysis and refinement, as well as of modelling, refinement and analysis of ordered solvent components, including small-molecule ligands.

  19. Reactions and Separations in Green Solvents

    NARCIS (Netherlands)

    Van Spronsen, J.

    2010-01-01

    Most chemical processes involve solvents in the reaction and the separation step. These solvents give rise to a heavy environmental and economical burden. Moreover, these solvents are based on non-sustainable resources like petroleum. The aim of this thesis has been to develop a number of alternativ

  20. Waste Classification based on Waste Form Heat Generation in Advanced Nuclear Fuel Cycles Using the Fuel-Cycle Integration and Tradeoffs (FIT) Model

    Energy Technology Data Exchange (ETDEWEB)

    Denia Djokic; Steven J. Piet; Layne F. Pincock; Nick R. Soelberg

    2013-02-01

    This study explores the impact of wastes generated from potential future fuel cycles and the issues presented by classifying these under current classification criteria, and discusses the possibility of a comprehensive and consistent characteristics-based classification framework based on new waste streams created from advanced fuel cycles. A static mass flow model, Fuel-Cycle Integration and Tradeoffs (FIT), was used to calculate the composition of waste streams resulting from different nuclear fuel cycle choices. This analysis focuses on the impact of waste form heat load on waste classification practices, although classifying by metrics of radiotoxicity, mass, and volume is also possible. The value of separation of heat-generating fission products and actinides in different fuel cycles is discussed. It was shown that the benefits of reducing the short-term fission-product heat load of waste destined for geologic disposal are neglected under the current source-based radioactive waste classification system , and that it is useful to classify waste streams based on how favorable the impact of interim storage is in increasing repository capacity.

  1. Advanced 3-D analysis, client-server systems, and cloud computing—Integration of cardiovascular imaging data into clinical workflows of transcatheter aortic valve replacement

    Science.gov (United States)

    Zimmermann, Mathis; Falkner, Juergen

    2013-01-01

    Degenerative aortic stenosis is highly prevalent in the aging populations of industrialized countries and is associated with poor prognosis. Surgical valve replacement has been the only established treatment with documented improvement of long-term outcome. However, many of the older patients with aortic stenosis (AS) are high-risk or ineligible for surgery. For these patients, transcatheter aortic valve replacement (TAVR) has emerged as a treatment alternative. The TAVR procedure is characterized by a lack of visualization of the operative field. Therefore, pre- and intra-procedural imaging is critical for patient selection, pre-procedural planning, and intra-operative decision-making. Incremental to conventional angiography and 2-D echocardiography, multidetector computed tomography (CT) has assumed an important role before TAVR. The analysis of 3-D CT data requires extensive post-processing during direct interaction with the dataset, using advance analysis software. Organization and storage of the data according to complex clinical workflows and sharing of image information have become a critical part of these novel treatment approaches. Optimally, the data are integrated into a comprehensive image data file accessible to multiple groups of practitioners across the hospital. This creates new challenges for data management requiring a complex IT infrastructure, spanning across multiple locations, but is increasingly achieved with client-server solutions and private cloud technology. This article describes the challenges and opportunities created by the increased amount of patient-specific imaging data in the context of TAVR. PMID:24282750

  2. Advanced 3-D analysis, client-server systems, and cloud computing-Integration of cardiovascular imaging data into clinical workflows of transcatheter aortic valve replacement.

    Science.gov (United States)

    Schoenhagen, Paul; Zimmermann, Mathis; Falkner, Juergen

    2013-06-01

    Degenerative aortic stenosis is highly prevalent in the aging populations of industrialized countries and is associated with poor prognosis. Surgical valve replacement has been the only established treatment with documented improvement of long-term outcome. However, many of the older patients with aortic stenosis (AS) are high-risk or ineligible for surgery. For these patients, transcatheter aortic valve replacement (TAVR) has emerged as a treatment alternative. The TAVR procedure is characterized by a lack of visualization of the operative field. Therefore, pre- and intra-procedural imaging is critical for patient selection, pre-procedural planning, and intra-operative decision-making. Incremental to conventional angiography and 2-D echocardiography, multidetector computed tomography (CT) has assumed an important role before TAVR. The analysis of 3-D CT data requires extensive post-processing during direct interaction with the dataset, using advance analysis software. Organization and storage of the data according to complex clinical workflows and sharing of image information have become a critical part of these novel treatment approaches. Optimally, the data are integrated into a comprehensive image data file accessible to multiple groups of practitioners across the hospital. This creates new challenges for data management requiring a complex IT infrastructure, spanning across multiple locations, but is increasingly achieved with client-server solutions and private cloud technology. This article describes the challenges and opportunities created by the increased amount of patient-specific imaging data in the context of TAVR.

  3. Integrated Advanced Microwave Sounding Unit-A (AMSU-A). Performance Verification Report: AMSU-A1 Antenna Drive Subsystem, PN 1331720-2, S/N 106

    Science.gov (United States)

    Luu, D.

    1999-01-01

    This is the Performance Verification Report, AMSU-A1 Antenna Drive Subsystem, P/N 1331720-2, S/N 106, for the Integrated Advanced Microwave Sounding Unit-A (AMSU-A). The antenna drive subsystem of the METSAT AMSU-A1, S/N 106, P/N 1331720-2, completed acceptance testing per A-ES Test Procedure AE-26002/lD. The test included: Scan Motion and Jitter, Pulse Load Bus Peak Current and Rise Time, Resolver Reading and Position Error, Gain/ Phase Margin, and Operational Gain Margin. The drive motors and electronic circuitry were also tested at the component level. The drive motor test includes: Starting Torque Test, Motor Commutation Test, Resolver Operation/ No-Load Speed Test, and Random Vibration. The electronic circuitry was tested at the Circuit Card Assembly (CCA) level of production; each test exercised all circuit functions. The transistor assembly was tested during the W3 cable assembly (1356941-1) test.

  4. Integrated biological and advanced oxidation based treatment of hexamine bearing wastewater: Effect of cow-dung as a co-substrate.

    Science.gov (United States)

    Gupta, Mandeep Kumar; Mittal, Atul K

    2016-05-05

    This work examines the treatment of hexamethylenetetramine (HMT) bearing effluent from N, N-dinitroso pentamethylene tetra-mine producing industrial plants in India. Chemical treatment using Fenton's reagent and aerobic treatment using batch reactors with co-substrate were investigated. Aerobic batch reactors integrated with advanced oxidation process of Fenton's reagent provides effective treatment of HMT effluents. Influence of Fenton's reagent dose reaction/contact and effect of varying co-substrate with effluent initial concentration was observed. Higher dose 100 mL of Fenton's reagent with higher reaction time 20 h resulted better degradation (34.88%) of wastewater. HMT hydrolyzes in acidic environment to ammonia and formaldehyde. Formaldehyde under normal conditions is toxic for biological treatment processes. When hydrolysis and acidification in the reactors are accompanied by low pH, aerobic batch reactors with use of co-substrates glucose, sucrose, and cow-dung extract separately in different proportion to wastewater ranging from 0.67 to 4.00, degraded wastewater effectively. Higher proportion of co-substrate to wastewater resulted better degradation. The relationships between nitrate, pH, turbidity and COD are discussed.

  5. Solvent cleaning system and method for removing contaminants from solvent used in resin recycling

    Science.gov (United States)

    Bohnert, George W.; Hand, Thomas E.; DeLaurentiis, Gary M.

    2009-01-06

    A two step solvent and carbon dioxide based system that produces essentially contaminant-free synthetic resin material and which further includes a solvent cleaning system for periodically removing the contaminants from the solvent so that the solvent can be reused and the contaminants can be collected and safely discarded in an environmentally safe manner.

  6. Nuclear Energy Advanced Modeling and Simulation (NEAMS) waste Integrated Performance and Safety Codes (IPSC) : gap analysis for high fidelity and performance assessment code development.

    Energy Technology Data Exchange (ETDEWEB)

    Lee, Joon H.; Siegel, Malcolm Dean; Arguello, Jose Guadalupe, Jr.; Webb, Stephen Walter; Dewers, Thomas A.; Mariner, Paul E.; Edwards, Harold Carter; Fuller, Timothy J.; Freeze, Geoffrey A.; Jove-Colon, Carlos F.; Wang, Yifeng

    2011-03-01

    This report describes a gap analysis performed in the process of developing the Waste Integrated Performance and Safety Codes (IPSC) in support of the U.S. Department of Energy (DOE) Office of Nuclear Energy Advanced Modeling and Simulation (NEAMS) Campaign. The goal of the Waste IPSC is to develop an integrated suite of computational modeling and simulation capabilities to quantitatively assess the long-term performance of waste forms in the engineered and geologic environments of a radioactive waste storage or disposal system. The Waste IPSC will provide this simulation capability (1) for a range of disposal concepts, waste form types, engineered repository designs, and geologic settings, (2) for a range of time scales and distances, (3) with appropriate consideration of the inherent uncertainties, and (4) in accordance with rigorous verification, validation, and software quality requirements. The gap analyses documented in this report were are performed during an initial gap analysis to identify candidate codes and tools to support the development and integration of the Waste IPSC, and during follow-on activities that delved into more detailed assessments of the various codes that were acquired, studied, and tested. The current Waste IPSC strategy is to acquire and integrate the necessary Waste IPSC capabilities wherever feasible, and develop only those capabilities that cannot be acquired or suitably integrated, verified, or validated. The gap analysis indicates that significant capabilities may already exist in the existing THC codes although there is no single code able to fully account for all physical and chemical processes involved in a waste disposal system. Large gaps exist in modeling chemical processes and their couplings with other processes. The coupling of chemical processes with flow transport and mechanical deformation remains challenging. The data for extreme environments (e.g., for elevated temperature and high ionic strength media) that are

  7. Molecular Thermodynamic Modeling of Mixed Solvent Solubility

    DEFF Research Database (Denmark)

    Ellegaard, Martin Dela; Abildskov, Jens; O’Connell, John P.

    2010-01-01

    A method based on statistical mechanical fluctuation solution theory for composition derivatives of activity coefficients is employed for estimating dilute solubilities of 11 solid pharmaceutical solutes in nearly 70 mixed aqueous and nonaqueous solvent systems. The solvent mixtures range from...... nearly ideal to strongly nonideal. The database covers a temperature range from 293 to 323 K. Comparisons with available data and other existing solubility methods show that the method successfully describes a variety of observed mixed solvent solubility behaviors using solute−solvent parameters from...... global regression of ternary data as well as predictions based on pure solvent solubilities with an average error of about 10% on mole fractions....

  8. Solvents and Parkinson disease: A systematic review of toxicological and epidemiological evidence

    Energy Technology Data Exchange (ETDEWEB)

    Lock, Edward A., E-mail: e.lock@ljmu.ac.uk [Liverpool John Moores University, School of Pharmacy and Biomolecular Sciences, Byrom Street, Liverpool (United Kingdom); Zhang, Jing [University of Washington, Department of Pathology, School of Medicine, Seattle, WA (United States); Checkoway, Harvey [University of Washington, Department of Environmental and Occupational Health Sciences, Seattle, WA (United States)

    2013-02-01

    Parkinson disease (PD) is a debilitating neurodegenerative motor disorder, with its motor symptoms largely attributable to loss of dopaminergic neurons in the substantia nigra. The causes of PD remain poorly understood, although environmental toxicants may play etiologic roles. Solvents are widespread neurotoxicants present in the workplace and ambient environment. Case reports of parkinsonism, including PD, have been associated with exposures to various solvents, most notably trichloroethylene (TCE). Animal toxicology studies have been conducted on various organic solvents, with some, including TCE, demonstrating potential for inducing nigral system damage. However, a confirmed animal model of solvent-induced PD has not been developed. Numerous epidemiologic studies have investigated potential links between solvents and PD, yielding mostly null or weak associations. An exception is a recent study of twins indicating possible etiologic relations with TCE and other chlorinated solvents, although findings were based on small numbers, and dose–response gradients were not observed. At present, there is no consistent evidence from either the toxicological or epidemiologic perspective that any specific solvent or class of solvents is a cause of PD. Future toxicological research that addresses mechanisms of nigral damage from TCE and its metabolites, with exposure routes and doses relevant to human exposures, is recommended. Improvements in epidemiologic research, especially with regard to quantitative characterization of long-term exposures to specific solvents, are needed to advance scientific knowledge on this topic. -- Highlights: ► The potential for organic solvents to cause Parkinson's disease has been reviewed. ► Twins study suggests etiologic relations with chlorinated solvents and Parkinson's. ► Animal studies with TCE showed potential to cause damage to dopaminergic neurons. ► Need to determine if effects in animals are relevant to human

  9. Integrated approach to advanced machining

    Energy Technology Data Exchange (ETDEWEB)

    LeSar, R.A.; Bourke, M.A.M.; Rangaswamy, P.; Day, R.D.; Hatch, D.J.

    1997-08-01

    The residual stress state induced by machining in a Ti alloy as function of cutting tool sharpness and depth of cut was predicted and measured. Residual stresses were greater for the dull tool than for the sharp tool. XRD was used to measure the residual stress state of the material; these measurements revealed that the hoop stress increased with depth of cut; however the radial stress decreased with depth of cut. An elastic-plastic model provided a possible explanation for this behavior in that, for small depths of cut, the tool makes multiple passes through the damage subsurface layer. This causes both residual stress components to increase, but the radial stress increases by a much greater amount than the hoop stress.

  10. Integrated Manufacturing for Advanced MEAs

    Energy Technology Data Exchange (ETDEWEB)

    Emory S. De Castro; Yu-Min Tsou; Mark G. Roelofs; Olga Polevaya

    2007-03-30

    This program addressed a two-pronged goal for developing fuel cell components: lowering of precious metal content in membrane electrode assemblies (MEAs), thereby reducing the fuel cell cost, and creating MEAs that can operate at 120oC and 25% RH whereby the system efficiency and effectiveness is greatly improved. In completing this program, we have demonstrated a significant reduction in precious metal while at the same time increasing the power output (achieved 2005 goal of 0.6g/Kw). We have also identified a technology that allows for one step fabrication of MEAs and appears to be a feasible path toward achieving DOE’s 2010 targets for precious metal and power (approaches 0.2g/Kw). Our team partner Du Pont invented a new class of polymer electrolyte membrane that has sufficient stability and conductivity to demonstrate feasibility for operation at 120 oC and low relative humidity. Through the course of this project, the public has benefited greatly from numerous presentations and publications on the technical understanding necessary to achieve these goals.

  11. Advancing Leadership

    Directory of Open Access Journals (Sweden)

    Penny L. Tenuto

    2014-04-01

    Full Text Available Preparing students to become active citizens and contributors to a democratic society is premised on teaching democratic principles and modeling standards of democratic practice at all levels of education. The purpose of this integrative literature review is to establish a conceptual framework grounded in literature and a model for cultivating democratic professional practice in education (DPPE to advance leadership for school improvement. This work is presented in three parts: (a a review of historical references, reports, and legislation that culminated in increased accountability and standards in P-12 public education; (b a discussion of social patterns in education generally associated with bureaucracy versus democracy; and (c a new contribution to the literature, a model for cultivating DPPE is conceptualized to encourage leading and teaching professionals to reflect on beliefs and evaluate practices in advancing leadership for school improvement. Recommendations are included for further research.

  12. Advanced capacitors

    Science.gov (United States)

    Ennis, J. B.; Buritz, R. S.

    1984-10-01

    This report describes an experimental program to develop and test advanced dielectric materials for capacitors for airborne power systems. Five classes of capacitors were considered: high rep rate and low rep rate pulse capacitors for use in pulse-forming networks, high voltage filter capacitors, high frequency AC capacitors for series resonant inverters, and AC filter capacitors. To meet these requirements, existing dielectric materials were modified, and new materials were developed. The initial goal was to develop an improved polysulfone film with fewer imperfections that could operate at significantly higher electrical stresses. It was shown that contaminants enter the film via the resin and solvent, and that they can be partially removed. As far as developed, however, these treatments did not significantly improved the breakdown characteristics. The technique of casting films on a roughened drum was demonstrated, and found useful in preparing textured films -- the first step toward a replacement for Kraft paper. A new material, Ultem, was proposed for use in high energy density capacitors. This new polyetherimide resin has properties similar to polysulfone and polyimide, with improvement in breakdown characteristics and temperature capability. This material was selected for further study in model capacitor designs.

  13. Effect of solvents on the characteristics of rosin walled microcapsules prepared by a solvent evaporation technique.

    Science.gov (United States)

    Sheorey, D S; Dorle, A K

    1991-01-01

    Rosin microcapsules were prepared by a solvent evaporation technique using solvents with different rates of evaporation. Sulphadiazine was used as a model drug. The microcapsules were studied for their size, drug content, wall thickness, surface characteristics and in vitro release. The mean diameter increased and the drug content decreased as the rate of evaporation of the solvent increased. Fast evaporating solvents produced thick walled microcapsules with innumerable surface pores/cracks compared with slow evaporating solvents.

  14. Thin-film composite crosslinked polythiosemicarbazide membranes for organic solvent nanofiltration (OSN)

    KAUST Repository

    Aburabie, Jamaliah

    2015-01-01

    In this work we report a new class of solvent stable thin-film composite (TFC) membrane fabricated on crosslinked polythiosemicarbazide (PTSC) as substrate that exhibits superior stability compared with other solvent stable polymeric membranes reported up to now. Integrally skinned asymmetric PTSC membranes were prepared by the phase inversion process and crosslinked with an aromatic bifunctional crosslinker to improve the solvent stability. TFC membranes were obtained via interfacial polymerization using trimesoyl chloride (TMC) and diaminopiperazine (DAP) monomers. The membranes were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and contact angle measurement.The membranes exhibited high fluxes toward solvents like tetrahydrofuran (THF), dimethylformamide (DMF) and dimethylsulfoxide (DMSO) ranging around 20L/m2 h at 5bar with a molecular weight cut off (MWCO) of around 1000g/mol. The PTSC-based thin-film composite membranes are very stable toward polar aprotic solvents and they have potential applications in the petrochemical and pharmaceutical industry.

  15. Advances in microwaves 8

    CERN Document Server

    Young, Leo

    2013-01-01

    Advances in Microwaves, Volume 8 covers the developments in the study of microwaves. The book discusses the circuit forms for microwave integrated circuits; the analysis of microstrip transmission lines; and the use of lumped elements in microwave integrated circuits. The text also describes the microwave properties of ferrimagnetic materials, as well as their interaction with electromagnetic waves propagating in bounded waveguiding structures. The integration techniques useful at high frequencies; material technology for microwave integrated circuits; specific requirements on technology for d

  16. Advanced control room design review guidelines: Integration of the NUREG-0700 guidelines and development of new human-system interface guidelines

    Energy Technology Data Exchange (ETDEWEB)

    Carter, R.J.

    1997-07-01

    This report documents the work conducted in four tasks of the Nuclear Regulatory Commission (NRC) project entitled Review Criteria for Human Factors Aspects of Advanced Controls and Instrumentation. The purpose of the first task was to integrate the applicable sections of NUREG-0700 into the advanced control room design review (ACRDR) guidelines to ensure that all applicable guidelines are together in one document and conveniently accessible to users. The primary objective of the second task was to formulate a strategy for the development of new ACRDR guidelines that have not otherwise been identified. The main focus of the third task was to modify the individual ACRDR guidelines generated to date to ensure that they are suitable for the intended nuclear power plant (NPP) control station system application. The goal of the fourth task was to develop human factors guidelines for two human-system interface categories that are missing from the current ACRDR guidelines document. During the first task those areas in NUREG-0700 that are not addressed by the ACRDR guidelines document were identified, the areas were subsequently reviewed against six recent industry human factors engineering review guidelines, and the NUREG-0700 guidelines were updated as necessary. In the second task 13 general categories of human-system interface guidelines that are either missing from or not adequately addressed by the ACRDR document were discovered. An approach was derived for the development of new ACRDR guidelines, a preliminary assessment of the available sources that may be useful in the creation of new guidelines and their applicability to the identified human-system interface categories was performed, and an estimate was made of the amount of time and level of effort required to complete the development of needed new ACRDR guidelines. During the third task those NPP control station systems to which the NUREG-0700 and ACRDR guidelines apply were identified, matrices of such

  17. Advanced calculus

    CERN Document Server

    Friedman, Avner

    2007-01-01

    This rigorous two-part treatment advances from functions of one variable to those of several variables. Intended for students who have already completed a one-year course in elementary calculus, it defers the introduction of functions of several variables for as long as possible, and adds clarity and simplicity by avoiding a mixture of heuristic and rigorous arguments.The first part explores functions of one variable, including numbers and sequences, continuous functions, differentiable functions, integration, and sequences and series of functions. The second part examines functions of several

  18. Advanced Microanalysis Facility

    Data.gov (United States)

    Federal Laboratory Consortium — The Advanced Microanalysis Facility fully integrates capabilities for chemical and structural analysis of electronic materials and devices for the U.S. Army and DoD....

  19. In situ aerobic cometabolism of chlorinated solvents: a review.

    Science.gov (United States)

    Frascari, Dario; Zanaroli, Giulio; Danko, Anthony S

    2015-01-01

    The possible approaches for in situ aerobic cometabolism of aquifers and vadose zones contaminated by chlorinated solvents are critically evaluated. Bioaugmentation of resting-cells previously grown in a fermenter and in-well addition of oxygen and growth substrate appear to be the most promising approaches for aquifer bioremediation. Other solutions involving the sparging of air lead to satisfactory pollutant removals, but must be integrated by the extraction and subsequent treatment of vapors to avoid the dispersion of volatile chlorinated solvents in the atmosphere. Cometabolic bioventing is the only possible approach for the aerobic cometabolic bioremediation of the vadose zone. The examined studies indicate that in situ aerobic cometabolism leads to the biodegradation of a wide range of chlorinated solvents within remediation times that vary between 1 and 17 months. Numerous studies include a simulation of the experimental field data. The modeling of the process attained a high reliability, and represents a crucial tool for the elaboration of field data obtained in pilot tests and for the design of the full-scale systems. Further research is needed to attain higher concentrations of chlorinated solvent degrading microbes and more reliable cost estimates. Lastly, a procedure for the design of full-scale in situ aerobic cometabolic bioremediation processes is proposed.

  20. One-pot preparation of unsaturated polyester nanocomposites containing functionalized graphene sheets via a novel solvent-exchange method

    Science.gov (United States)

    This paper reports a convenient one-pot method integrating a novel solvent-exchange method into in situ melt polycondensation to fabricate unsaturated polyester nanocomposites containing functionalized graphene sheets (FGS). A novel solvent-exchange method was first developed to prepare graphene oxi...

  1. Integrated NY-ESO-1 antibody and CD8+ T-cell responses correlate with clinical benefit in advanced melanoma patients treated with ipilimumab.

    Science.gov (United States)

    Yuan, Jianda; Adamow, Matthew; Ginsberg, Brian A; Rasalan, Teresa S; Ritter, Erika; Gallardo, Humilidad F; Xu, Yinyan; Pogoriler, Evelina; Terzulli, Stephanie L; Kuk, Deborah; Panageas, Katherine S; Ritter, Gerd; Sznol, Mario; Halaban, Ruth; Jungbluth, Achim A; Allison, James P; Old, Lloyd J; Wolchok, Jedd D; Gnjatic, Sacha

    2011-10-04

    Ipilimumab, a monoclonal antibody against cytotoxic T lymphocyte antigen 4 (CTLA-4), has been shown to improve survival in patients with advanced metastatic melanoma. It also enhances immunity to NY-ESO-1, a cancer/testis antigen expressed in a subset of patients with melanoma. To characterize the association between immune response and clinical outcome, we first analyzed NY-ESO-1 serum antibody by ELISA in 144 ipilimumab-treated patients with melanoma and found 22 of 140 (16%) seropositive at baseline and 31 of 144 (22%) seropositive following treatment. These NY-ESO-1-seropositive patients had a greater likelihood of experiencing clinical benefit 24 wk after ipilimumab treatment than NY-ESO-1-seronegative patients (P = 0.02, relative risk = 1.8, two-tailed Fisher test). To understand why some patients with NY-ESO-1 antibody failed to experience clinical benefit, we analyzed NY-ESO-1-specific CD4(+) and CD8(+) T-cell responses by intracellular multicytokine staining in 20 NY-ESO-1-seropositive patients and found a surprising dissociation between NY-ESO-1 antibody and CD8 responses in some patients. NY-ESO-1-seropositive patients with associated CD8(+) T cells experienced more frequent clinical benefit (10 of 13; 77%) than those with undetectable CD8(+) T-cell response (one of seven; 14%; P = 0.02; relative risk = 5.4, two-tailed Fisher test), as well as a significant survival advantage (P = 0.01; hazard ratio = 0.2, time-dependent Cox model). Together, our data suggest that integrated NY-ESO-1 immune responses may have predictive value for ipilimumab treatment and argue for prospective studies in patients with established NY-ESO-1 immunity. The current findings provide a strong rationale for the clinical use of modulators of immunosuppression with concurrent approaches to favor tumor antigen-specific immune responses, such as vaccines or adoptive transfer, in patients with cancer.

  2. Dynamics around solutes and solute-solvent complexes in mixed solvents.

    Science.gov (United States)

    Kwak, Kyungwon; Park, Sungnam; Fayer, M D

    2007-09-04

    Ultrafast 2D-IR vibrational echo experiments, IR pump-probe experiments, and FT-IR spectroscopy of the hydroxyl stretch of phenol-OD in three solvents, CCl4, mesitylene (1, 3, 5 trimethylbenzene), and the mixed solvent of mesitylene and CCl4 (0.83 mole fraction CCl4), are used to study solute-solvent dynamics via observation of spectral diffusion. Phenol forms a complex with Mesitylene. In the mesitylene solution, there is only complexed phenol; in the CCl4 solution, there is only uncomplexed phenol; and in the mixed solvent, both phenol species are present. Dynamics of the free phenol in CCl4 or the mixed solvent are very similar, and dynamics of the complex in mesitylene and in the mixed solvent are very similar. However, there are differences in the slowest time scale dynamics between the pure solvents and the mixed solvents. The mixed solvent produces slower dynamics that are attributed to first solvent shell solvent composition variations. The composition variations require a longer time to randomize than is required in the pure solvents, where only density variations occur. The experimental results and recent MD simulations indicate that the solvent structure around the solute may be different from the mixed solvent's mole fraction.

  3. NMR Chemical Shift Ranges of Urine Metabolites in Various Organic Solvents

    Directory of Open Access Journals (Sweden)

    Benjamin Görling

    2016-09-01

    Full Text Available Signal stability is essential for reliable multivariate data analysis. Urine samples show strong variance in signal positions due to inter patient differences. Here we study the exchange of the solvent of a defined urine matrix and how it affects signal and integral stability of the urinary metabolites by NMR spectroscopy. The exchange solvents were methanol, acetonitrile, dimethyl sulfoxide, chloroform, acetone, dichloromethane, and dimethyl formamide. Some of these solvents showed promising results with a single batch of urine. To evaluate further differences between urine samples, various acid, base, and salt solutions were added in a defined way mimicking to some extent inter human differences. Corresponding chemical shift changes were monitored.

  4. NMR Chemical Shift Ranges of Urine Metabolites in Various Organic Solvents

    Science.gov (United States)

    Görling, Benjamin; Bräse, Stefan; Luy, Burkhard

    2016-01-01

    Signal stability is essential for reliable multivariate data analysis. Urine samples show strong variance in signal positions due to inter patient differences. Here we study the exchange of the solvent of a defined urine matrix and how it affects signal and integral stability of the urinary metabolites by NMR spectroscopy. The exchange solvents were methanol, acetonitrile, dimethyl sulfoxide, chloroform, acetone, dichloromethane, and dimethyl formamide. Some of these solvents showed promising results with a single batch of urine. To evaluate further differences between urine samples, various acid, base, and salt solutions were added in a defined way mimicking to some extent inter human differences. Corresponding chemical shift changes were monitored. PMID:27598217

  5. Lebesgue integration

    CERN Document Server

    Williamson, JH

    2014-01-01

    This concise introduction to Lebesgue integration is geared toward advanced undergraduate math majors and may be read by any student possessing some familiarity with real variable theory and elementary calculus. The self-contained treatment features exercises at the end of each chapter that range from simple to difficult. The approach begins with sets and functions and advances to Lebesgue measure, including considerations of measurable sets, sets of measure zero, and Borel sets and nonmeasurable sets. A two-part exploration of the integral covers measurable functions, convergence theorems, co

  6. OCCUPATIONAL SOLVENT EXPOSURE ASSOCIATED WITH DEVELOPMENTAL TOXICITY

    Directory of Open Access Journals (Sweden)

    Alina-Costina LUCA

    2016-05-01

    Full Text Available Organic solvent is a broad term that applies to many classes of chemicals. The solvent (benzene, toluene etc. aspects of occupational exposure are reviewed via the examination of the use, occurrence, and disposition as well as population’s potential of risk. The general public can be exposed to solvent in ambient air as a result of its occurrence in paint process. Solvents are primarily irritants to the skin and mucous membranes and have narcotic properties at high concentrations. Published epidemiological data identified various types of birth defects in certain occupations.

  7. A solvent tolerant isolate of Enterobacter aerogenes.

    Science.gov (United States)

    Gupta, Anshu; Singh, Rajni; Khare, S K; Gupta, M N

    2006-01-01

    A solvent tolerant strain of Enterobacter aerogenes was isolated from soil by cyclohexane enrichment. Presence of cyclohexane (20%) in culture media prolonged the lag phase and caused reduction in biomass. Transmission electron micrographs showed convoluted cell membrane and accumulation of solvent in case of the cells grown in cyclohexane. The Enterobacter isolate was able to grow in the range of organic solvents having log P above 3.2 and also in presence of mercury, thus showing potential for treatment of solvent rich wastes.

  8. Extractive Distillation with Salt in Solvent

    Institute of Scientific and Technical Information of China (English)

    1999-01-01

    Extractive distillation with salt in solvent is a new process for producing anhydrous ethanol by combining the principle of "salt effect" and some traditional extractive distillation methods. Compared with the common extractive distillation the performance of solvent is improved, the recycling amount of solvent is reduced to 1/4-1/5, and the number of theoretical plates is reduced to 1/3. Energy consumption and cost of equipment are also reduced and continuous production is realized. High efficiency and low solvent wastage make this technique feasible.

  9. Organic solvent use in enterprises in Japan.

    Science.gov (United States)

    Nagasawa, Yasuhiro; Ukai, Hirohiko; Okamoto, Satoru; Samoto, Hajime; Itoh, Kenji; Moriguchi, Jiro; Sakuragi, Sonoko; Ohashi, Fumiko; Takada, Shiro; Kawakami, Tetsuya; Ikeda, Masayuki

    2011-01-01

    This study was initiated to elucidate possible changes in types of organic solvents (to be called solvents in short) used in enterprises in Japan through comparison of current solvent types with historical data since 1983. To investigate current situation in solvent use in enterprises, surveys were conducted during one year of 2009 to 2010. In total, workroom air samples in 1,497 unit workplaces with solvent use were analyzed in accordance with regulatory requirements. Typical use pattern of solvents was as mixtures, accounting for >70% of cases. Adhesives spreading (followed by adhesion) was relatively common in small-scale enterprises, whereas printing and painting work was more common in middle-scale ones, and solvent use for testing and research purpose was basically in large-scaled enterprises. Through-out printing, painting, surface coating and adhesive application, toluene was most common (being detected in 49 to 82% of workplaces depending on work types), whereas isopropyl alcohol was most common (49%) in degreasing, cleaning and wiping workplaces. Other commonly used solvents were methyl alcohol, ethyl acetate and acetone (33 to 37%). Comparison with historical data in Japan and literature-retrieved data outside of Japan all agreed with the observation that toluene is the most commonly used solvent. Application of trichloroethylene and 1,1,1-trichloroethane, once common in 1980s, has ceased to exist in recent years.

  10. Interfacial Phenomena in Solvent Extraction and Its Influence on Process Performance

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    Solvent extraction is now finding applications in a broader range of fields than the past. Many of these applications require process equipment with shorter contact times, and in some cases to the point where the traditional equilibrium stage approach is not a good model for predicting performance. In addition,feed streams are becoming lower in concentration of the solute. This means greater feed to solvent flow ratios are being used and so loss of organics as entrainment in the feed is more of a concern both economically and environmentally. These trends mean that a greater emphasis is being placed on the kinetics of extraction and stripping in models to predict performance and on formation and coalescence of drops to control entrainment. This paper reviews recent advances in the tools for investigating kinetics and coalescence in solvent extraction processes and some of the insights that are being uncovered in these fundamental processes in solvent extraction technology.

  11. Effects of organic solvents on the enzyme activity of Trypanosoma cruzi glyceraldehyde-3-phosphate dehydrogenase in calorimetric assays

    DEFF Research Database (Denmark)

    Wiggers, Henrik; Cheleski, J; Zottis, A

    2007-01-01

    is sixfold higher. The favorable effects of the organic solvents on the Michaelis-Menten enzyme-substrate complex formation ensure the consistency of the biological assays, structural integrity of the protein, and reproducibility over the measurement time. The reaction was also kinetically monitored......In drug discovery programs, dimethyl sulfoxide (DMSO) is a standard solvent widely used in biochemical assays. Despite the extensive use and study of enzymes in the presence of organic solvents, for some enzymes the effect of organic solvent is unknown. Macromolecular targets may be affected...... by the presence of different solvents in such a way that conformational changes perturb their active site structure accompanied by dramatic variations in activity when performing biochemical screenings. To address this issue, in this work we studied the effects of two organic solvents, DMSO and methanol (Me...

  12. Solvent substitution: an analysis of comprehensive hazard screening indices.

    Science.gov (United States)

    Debia, M; Bégin, D; Gérin, M

    2011-06-01

    The air index (ψ(i)(air)) of the PARIS II software (Environmental Protection Agency), the Indiana Relative Chemical Hazard Score (IRCHS), and the Final Hazard Score (FHS) used in the P2OASys system (Toxics Use Reduction Institute) are comprehensive hazard screening indices that can be used in solvent substitution. The objective of this study was to evaluate these indices using a list of 67 commonly used or recommended solvents. The indices ψ(i)(air), IRCHS and FHS were calculated considering 9, 13, and 33 parameters, respectively, that summarized health and safety hazards, and environmental impacts. Correlation and sensitivity analyses were performed. The vapor hazard ratio (VHR) was used as a reference point. Two good correlations were found: (1) between VHR and ψ(i)(air) (ρ = 0.84), (2) and between IRCHS and FHS (ρ = 0.81). Values of sensitivity ratios above 0.2 were found with ψ(i)(air) (4 of 9 parameters) and IRCHS (3 of 13 parameters), but not with FHS. Overall, the three indices exhibited important differences in the way they integrate key substitution factors, such as volatility, occupational exposure limit, skin exposure, flammability, carcinogenicity, photochemical oxidation potential, atmospheric global effects, and environmental terrestrial and aquatic effects. These differences can result in different choices of alternatives between indices, including the VHR. IRCHS and FHS are the most comprehensive indices but are very tedious and complex to use and lack sensitivity to several solvent-specific parameters. The index ψ(i)(air) is simpler to calculate but does not cover some parameters important to solvents. There is presently no suitably comprehensive tool available for the substitution of solvents. A two-tier approach for the selection of solvents is recommended to avoid errors that could be made using only a global index or the consideration of the simple VHR. As a first tier, one would eliminate solvent candidates having crucial impacts. As a

  13. Additive diffusion from LDPE slabs into contacting solvents as a function of solvent absorption

    NARCIS (Netherlands)

    Helmroth, I.E.; Dekker, M.; Hankemeier, Th.

    2003-01-01

    This article describes the simultaneous diffusion of a migrant and a solvent in low density polyethylene (LDPE). The migrant (Irganox 1076) moves out of the slab, while the solvent (isooctane, n-heptane or cyclohexane) moves inwards. Solvent absorption was measured separately by following the increa

  14. Additive Diffusion from LDPE Slabs into Contacting Solvents as a Function of Solvent Absorption

    NARCIS (Netherlands)

    Helmroth, I.E.; Dekker, M.; Hankemeier, T.

    2003-01-01

    This article describes the simultaneous diffusion of a migrant and a solvent in low density polyethylene (LDPE). The migrant (Irganox 1076) moves out of the slab, while the solvent (isooctane, n-heptane or cyclohexane) moves inwards. Solvent absorption was measured separately by following the increa

  15. Relationship between Fermi Resonance and Solvent Effects

    Institute of Scientific and Technical Information of China (English)

    JIANG Xiu-Lan; LI Dong-Fei; SUN Cheng-Lin; LI Zhan-Long; YANG Guang; ZHOU Mi; LI Zuo-Wei; GAO Shu-Qin

    2011-01-01

    We theoretically and experimentally study the relationship between Fermi resonance and solvent effects and investigate the Fermi resonance of p-benzoquinone and cyclopentanone in different solvents and the Fermi resonance of CS2 in C6H6 at different concentrations. Also, we investigate the Fermi resonance of C6H6 and CCl4 in their solution at different pressures. It is found that solvent effects can be utilized to search Fermi resonance parameters such as coupling coefficient and spectral intensity ratio, etc., on the other hand, the mechanism of solvent effects can be revealed according to Fermi resonance at high pressure.%@@ We theoretically and experimentally study the relationship between Fermi resonance and solvent effects and investigate the Fermi resonance of p-benzoquinone and cyclopentanone in different solvents and the Fermi resonance of CS2 in C6H6 at different concentrations.Also,we investigate the Fermi resonance of C6H6 and CCl4 in their solution at different pressures.It is found that solvent effects can be utilized to search Fermi resonance parameters such as coupling coefficient and spectral intensity ratio,etc.,on the other hand,the mechanism of solvent effects can be revealed according to Fermi resonance at high pressure.

  16. Solvation of rhodamine575 in some solvents

    Science.gov (United States)

    Sharma, Amit

    2016-05-01

    FTIR spectra of Rhodamine575 dye in powder form and in different solvents are reported. Positions of some of the observed FTIR bands show noticeable change in solvents. The bands, which shift, have contributions from the vibrational motion of nitrogen atoms of the ethylamine groups, oxygen atom of the carboxylic group attached to the phenyl ring and oxygen atom of the Xanthene ring.

  17. Solvent effect in the Walden inversion reactions

    Science.gov (United States)

    Jaume, J.; Lluch, J. M.; Oliva, A.; Bertrán, J.

    1984-04-01

    The solvent effect on the fluoride exchange reaction has been studied by means of ab initio calculations using the 3-21G basis set. It is shown that the motion of the solvent molecules is an important part of the reaction coordinate.

  18. Freeform electronics for advanced healthcare

    KAUST Repository

    Hussain, Muhammad Mustafa

    2017-02-16

    Freeform (physically flexible, stretchable and reconfigurable) electronics can be critical enabler for advanced personalized healthcare. With increased global population and extended average lifetime of mankind, it is more important than ever to integrate advanced electronics into our daily life for advanced personalized healthcare. In this paper, we discuss some critical criteria to design such electronics with enabling applications.

  19. Efficient cellulose solvent: quaternary ammonium chlorides.

    Science.gov (United States)

    Kostag, Marc; Liebert, Tim; El Seoud, Omar A; Heinze, Thomas

    2013-10-01

    Pure quaternary tetraalkylammonium chlorides with one long alkyl chain dissolved in various organic solvents constitute a new class of cellulose solvents. The electrolytes are prepared in high yields and purity by Menshutkin quaternization, an inexpensive and easy synthesis route. The pure molten tetraalkylammonium chlorides dissolve up to 15 wt% of cellulose. Cosolvents, including N,N-dimethylacetamide (DMA), may be added in large excess, leading to a system of decreased viscosity. Contrary to the well-established solvent DMA/LiCl, cellulose dissolves in DMA/quaternary ammonium chlorides without any pretreatment. Thus, the use of the new solvent avoids some disadvantages of DMA/LiCl and ionic liquids, the most extensively employed solvents for homogeneous cellulose chemistry.

  20. Assessment of solvents for cellulose dissolution.

    Science.gov (United States)

    Ghasemi, Mohammad; Tsianou, Marina; Alexandridis, Paschalis

    2017-03-01

    A necessary step in the processing of biomass is the pretreatment and dissolution of cellulose. A good solvent for cellulose involves high diffusivity, aggressiveness in decrystallization, and capability of disassociating the cellulose chains. However, it is not clear which of these factors and under what conditions should be improved in order to obtain a more effective solvent. To this end, a newly-developed phenomenological model has been applied to assess the controlling mechanism of cellulose dissolution. Among the findings, the cellulose fibers remain crystalline almost to the end of the dissolution process for decrystallization-controlled kinetics. In such solvents, decreasing the fiber crystallinity, e.g., via pretreatment, would result in a considerable increase in the dissolution rate. Such insights improve the understanding of cellulose dissolution and facilitate the selection of more efficient solvents and processing conditions for biomass. Specific examples of solvents are provided where dissolution is limited due to decrystallization or disentanglement.

  1. Toxic hepatitis in occupational exposure to solvents

    Institute of Scientific and Technical Information of China (English)

    Giulia Malaguarnera; Emanuela Cataudella; Maria Giordano; Giuseppe Nunnari; Giuseppe Chisari; Mariano Malaguarnera

    2012-01-01

    The liver is the main organ responsible for the metabolism of drugs and toxic chemicals,and so is the primary target organ for many organic solvents.Work activities with hepatotoxins exposures are numerous and,moreover,organic solvents are used in various industrial processes.Organic solvents used in different industrial processes may be associated with hepatotoxicity.Several factors contribute to liver toxicity; among these are:species differences,nutritional condition,genetic factors,interaction with medications in use,alcohol abuse and interaction,and age.This review addresses the mechanisms of hepatotoxicity.The main pathogenic mechanisms responsible for functional and organic damage caused by solvents are:inflammation,dysfunction of cytochrome P450,mitochondrial dysfunction and oxidative stress.The health impact of exposure to solvents in the workplace remains an interesting and worrying question for professional health work.

  2. Computer Aided Solvent Selection and Design Framework

    DEFF Research Database (Denmark)

    Mitrofanov, Igor; Conte, Elisa; Abildskov, Jens

    for indentifying the best candidates depending on different multi-objective criteria namely environment, health, safety, process feasibility and economics. One of the criteria of solvent selection is the environmental impact because of the excessive consumption and utilization in a wide range of industries......Solvents are widely used as a reaction medium, as a reactant or as carrier at some stages of the manufacturing chain in products from the chemical, fine chemical, pharmaceutical, food, and agrochemical industries. Solvent are either required for processing after which they are removed...... or they are part of the final product formulation. Therefore, solvents are playing an important role in product synthesis and formulation, product delivery, separation processes etc [1]. On the other hand, solvent selection and design is a complex problem, which requires decision making in several levels...

  3. Integration of Advanced Manufacturing Supply Chain and Construction of Shanghai International Trade Center%先进制造业供应链整合与上海国际贸易中心建设

    Institute of Scientific and Technical Information of China (English)

    李红霞

    2011-01-01

    目前中国企业只是处于全球供应链的最末端,制造业特别是先进制造业供应链整合对推进上海国际贸易中心建设有着非常重要的意义。上海先进制造业供应链整合的目标主要是将物流、信息流、资金流等有效整合,从而能够提高利润、降低成本、提高服务质量和响应速度。就上海制造业供应链整合的现状,结合国外经验启示,提出整合先进制造业供应链,推进上海国际贸易中心建设的对策措施。%At present, China's enterprises are only at the end of the global supply chain. Manufacturing industries, especially the integration of advanced manufacturing supply chain play a significant role in promoting the construction of Shanghai international trade center. Shanghai's advanced manufacturing supply chain targets mainly at effective integration of logistics, information flow and capital flow, which can increase profits, reduce costs and improve service quality and responsiveness. Based on the status quo of integration of Shanghai manufacturing supply chain, combined with experience, countermeasures of integrating advanced manufacturing supply chain were proposed to promote the construction of Shanghai International Trade Center.

  4. The chemistry of nonaqueous solvents v.4 solution phenomena and aprotic solvents

    CERN Document Server

    Lagowski, J J

    1976-01-01

    The Chemistry of Nonaqueous Solvents, Volume IV: Solution Phenomena and Aprotic Solvents focuses on the chemistry of nonaqueous solvents, with emphasis on solution phenomena and aprotic solvents such as tetramethylurea, inorganic acid chlorides, cyclic carbonates, and sulfolane. This book is organized into seven chapters and begins with an overview of the theory of electrical conductivity and elementary experimental considerations, along with some of the interesting research on nonaqueous solvents. It then turns to a discussion on hydrogen bonding phenomena in nonaqueous systems as probed

  5. PARIS II: Computer Aided Solvent Design for Pollution Prevention

    Science.gov (United States)

    This product is a summary of U.S. EPA researchers' work developing the solvent substitution software tool PARIS II (Program for Assisting the Replacement of Industrial Solvents, version 2.0). PARIS II finds less toxic solvents or solvent mixtures to replace more toxic solvents co...

  6. Predicting the Solubility of Pharmaceutical Cocrystals in Solvent/Anti-Solvent Mixtures

    Directory of Open Access Journals (Sweden)

    Linda Lange

    2016-05-01

    Full Text Available In this work, the solubilities of pharmaceutical cocrystals in solvent/anti-solvent systems were predicted using PC-SAFT in order to increase the efficiency of cocrystal formation processes. Modeling results and experimental data were compared for the cocrystal system nicotinamide/succinic acid (2:1 in the solvent/anti-solvent mixtures ethanol/water, ethanol/acetonitrile and ethanol/ethyl acetate at 298.15 K and in the ethanol/ethyl acetate mixture also at 310.15 K. The solubility of the investigated cocrystal slightly increased when adding small amounts of anti-solvent to the solvent, but drastically decreased for high anti-solvent amounts. Furthermore, the solubilities of nicotinamide, succinic acid and the cocrystal in the considered solvent/anti-solvent mixtures showed strong deviations from ideal-solution behavior. However, by accounting for the thermodynamic non-ideality of the components, PC-SAFT is able to predict the solubilities in all above-mentioned solvent/anti-solvent systems in good agreement with the experimental data.

  7. Integration of Advanced Concepts and Vehicles Into the Next Generation Air Transportation System. Volume 1; Introduction, Key Messages, and Vehicle Attributes

    Science.gov (United States)

    Zellweger, Andres; Resnick, Herbert; Stevens, Edward; Arkind, Kenneth; Cotton William B.

    2010-01-01

    Raytheon, in partnership with NASA, is leading the way in ensuring that the future air transportation continues to be a key driver of economic growth and stability and that this system provides an environmentally friendly, safe, and effective means of moving people and goods. A Raytheon-led team of industry and academic experts, under NASA contract NNA08BA47C, looked at the potential issues and impact of introducing four new classes of advanced aircraft into the next generation air transportation system -- known as NextGen. The study will help determine where NASA should further invest in research to support the safe introduction of these new air vehicles. Small uncrewed or unmanned aerial systems (SUAS), super heavy transports (SHT) including hybrid wing body versions (HWB), very light jets (VLJ), and supersonic business jets (SSBJ) are the four classes of aircraft that we studied. Understanding each vehicle's business purpose and strategy is critical to assessing the feasibility of new aircraft operations and their impact on NextGen's architecture. The Raytheon team used scenarios created by aviation experts that depict vehicles in year 2025 operations along with scripts or use cases to understand the issues presented by these new types of vehicles. The information was then mapped into the Joint Planning and Development Office's (JPDO s) Enterprise Architecture to show how the vehicles will fit into NextGen's Concept of Operations. The team also identified significant changes to the JPDO's Integrated Work Plan (IWP) to optimize the NextGen vision for these vehicles. Using a proven enterprise architecture approach and the JPDO s Joint Planning Environment (JPE) web site helped make the leap from architecture to planning efficient, manageable and achievable. Very Light Jets flying into busy hub airports -- Supersonic Business Jets needing to climb and descend rapidly to achieve the necessary altitude Super-heavy cargo planes requiring the shortest common flight

  8. Solvent Effect on the Photolysis of Riboflavin.

    Science.gov (United States)

    Ahmad, Iqbal; Anwar, Zubair; Ahmed, Sofia; Sheraz, Muhammad Ali; Bano, Raheela; Hafeez, Ambreen

    2015-10-01

    The kinetics of photolysis of riboflavin (RF) in water (pH 7.0) and in organic solvents (acetonitrile, methanol, ethanol, 1-propanol, 1-butanol, ethyl acetate) has been studied using a multicomponent spectrometric method for the assay of RF and its major photoproducts, formylmethylflavin and lumichrome. The apparent first-order rate constants (k obs) for the reaction range from 3.19 (ethyl acetate) to 4.61 × 10(-3) min(-1) (water). The values of k obs have been found to be a linear function of solvent dielectric constant implying the participation of a dipolar intermediate along the reaction pathway. The degradation of this intermediate is promoted by the polarity of the medium. This indicates a greater stabilization of the excited-triplet states of RF with an increase in solvent polarity to facilitate its reduction. The rate constants for the reaction show a linear relation with the solvent acceptor number indicating the degree of solute-solvent interaction in different solvents. It would depend on the electron-donating capacity of RF molecule in organic solvents. The values of k obs are inversely proportional to the viscosity of the medium as a result of diffusion-controlled processes.

  9. Organic Solvent Tolerant Lipases and Applications

    Directory of Open Access Journals (Sweden)

    Shivika Sharma

    2014-01-01

    Full Text Available Lipases are a group of enzymes naturally endowed with the property of performing reactions in aqueous as well as organic solvents. The esterification reactions using lipase(s could be performed in water-restricted organic media as organic solvent(s not only improve(s the solubility of substrate and reactant in reaction mixture but also permit(s the reaction in the reverse direction, and often it is easy to recover the product in organic phase in two-phase equilibrium systems. The use of organic solvent tolerant lipase in organic media has exhibited many advantages: increased activity and stability, regiospecificity and stereoselectivity, higher solubility of substrate, ease of products recovery, and ability to shift the reaction equilibrium toward synthetic direction. Therefore the search for organic solvent tolerant enzymes has been an extensive area of research. A variety of fatty acid esters are now being produced commercially using immobilized lipase in nonaqueous solvents. This review describes the organic tolerance and industrial application of lipases. The main emphasis is to study the nature of organic solvent tolerant lipases. Also, the potential industrial applications that make lipases the biocatalysts of choice for the present and future have been presented.

  10. Polar Solvents Trigger Formation of Reverse Micelles.

    Science.gov (United States)

    Khoshnood, Atefeh; Firoozabadi, Abbas

    2015-06-09

    We use molecular dynamics simulations and molecular thermodynamics to investigate the formation of reverse micelles in a system of surfactants and nonpolar solvents. Since the early observation of reverse micelles, the question has been whether the existence of polar solvent molecules such as water is the driving force for the formation of reverse micelles in nonpolar solvents. In this work, we use a simple coarse-grained model of surfactants and solvents to show that a small number of polar solvent molecules triggers the formation of large permanent aggregates. In the absence of polar molecules, both the thermodynamic model and molecular simulations show that small aggregates are more populated in the solution and larger ones are less frequent as the system evolves over time. The size and shape of reverse micelles depend on the size of the polar core: the shape is spherical for a large core and ellipsoidal for a smaller one. Using the coarse-grained model, we also investigate the effect of temperature and surfactant tail length. Our results reveal that the number of surfactant molecules in the micelle decreases as the temperature increases, but the average diameter does not change because the size of the polar core remains invariant. A reverse micelle with small polar core attracts fewer surfactants when the tail is long. The uptake of solvent particles by a micelle of longer surfactant tail is less than shorter ones when the polar solvent particles are initially distributed randomly.

  11. Auditory dysfunction associated with solvent exposure

    Directory of Open Access Journals (Sweden)

    Fuente Adrian

    2013-01-01

    Full Text Available Abstract Background A number of studies have demonstrated that solvents may induce auditory dysfunction. However, there is still little knowledge regarding the main signs and symptoms of solvent-induced hearing loss (SIHL. The aim of this research was to investigate the association between solvent exposure and adverse effects on peripheral and central auditory functioning with a comprehensive audiological test battery. Methods Seventy-two solvent-exposed workers and 72 non-exposed workers were selected to participate in the study. The test battery comprised pure-tone audiometry (PTA, transient evoked otoacoustic emissions (TEOAE, Random Gap Detection (RGD and Hearing-in-Noise test (HINT. Results Solvent-exposed subjects presented with poorer mean test results than non-exposed subjects. A bivariate and multivariate linear regression model analysis was performed. One model for each auditory outcome (PTA, TEOAE, RGD and HINT was independently constructed. For all of the models solvent exposure was significantly associated with the auditory outcome. Age also appeared significantly associated with some auditory outcomes. Conclusions This study provides further evidence of the possible adverse effect of solvents on the peripheral and central auditory functioning. A discussion of these effects and the utility of selected hearing tests to assess SIHL is addressed.

  12. Prediction of Corrosion of Alloys in Mixed-Solvent Environments

    Energy Technology Data Exchange (ETDEWEB)

    Anderko, Andrzej [OLI Systems Inc. Morris Plains (United States); Wang, Peiming [OLI Systems Inc. Morris Plains (United States); Young, Robert D. [OLI Systems Inc. Morris Plains (United States); Riemer, Douglas P. [OLI Systems Inc. Morris Plains (United States); McKenzie, Patrice [OLI Systems Inc. Morris Plains (United States); Lencka, Malgorzata M. [OLI Systems Inc. Morris Plains (United States); Babu, Sudarsanam Suresh [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Angelini, Peter [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2003-06-05

    Corrosion is much less predictable in organic or mixed-solvent environments than in aqueous process environments. As a result, US chemical companies face greater uncertainty when selecting process equipment materials to manufacture chemical products using organic or mixed solvents than when the process environments are only aqueous. Chemical companies handle this uncertainty by overdesigning the equipment (wasting money and energy), rather than by accepting increased risks of corrosion failure (personnel hazards and environmental releases). Therefore, it is important to develop simulation tools that would help the chemical process industries to understand and predict corrosion and to develop mitigation measures. To create such tools, we have developed models that predict (1) the chemical composition, speciation, phase equilibria, component activities and transport properties of the bulk (aqueous, nonaqueous or mixed) phase that is in contact with the metal; (2) the phase equilibria and component activities of the alloy phase(s) that may be subject to corrosion and (3) the interfacial phenomena that are responsible for corrosion at the metal/solution or passive film/solution interface. During the course of this project, we have completed the following: (1) Development of thermodynamic modules for calculating the activities of alloy components; (2) Development of software that generates stability diagrams for alloys in aqueous systems; these diagrams make it possible to predict the tendency of metals to corrode; (3) Development and extensive verification of a model for calculating speciation, phase equilibria and thermodynamic properties of mixed-solvent electrolyte systems; (4) Integration of the software for generating stability diagrams with the mixed-solvent electrolyte model, which makes it possible to generate stability diagrams for nonaqueous or mixed-solvent systems; (5) Development of a model for predicting diffusion coefficients in mixed-solvent electrolyte

  13. TRUEX process solvent cleanup with solid sorbents

    Energy Technology Data Exchange (ETDEWEB)

    Tse, Pui-Kwan; Reichley-Yinger, L.; Vandegrift, G.F.

    1989-01-01

    Solid sorbents, alumina, silica gel, and Amberlyst A-26 have been tested for the cleanup of degraded TRUEX-NPH solvent. A sodium carbonate scrub alone does not completely remove acidic degradation products from highly degraded solvent and cannot restore the stripping performance of the solvent. By following the carbonate scrub with either neutral alumina or Amberlyst A-26 anion exchange resin, the performance of the TRUEX-NPH is substantially restored. The degraded TRUEX-NPH was characterized before and after treatment by supercritical fluid chromatography. Its performance was evaluated by americium distribution ratios, phase-separation times, and lauric acid distribution coefficients. 17 refs., 2 figs., 5 tabs.

  14. Modeling of Salt Solubilities in Mixed Solvents

    DEFF Research Database (Denmark)

    Chiavone-Filho, O.; Rasmussen, Peter

    2000-01-01

    A method to correlate and predict salt solubilities in mixed solvents using a UNIQUAC+Debye-Huckel model is developed. The UNIQUAC equation is applied in a form with temperature-dependent parameters. The Debye-Huckel model is extended to mixed solvents by properly evaluating the dielectric...... constants and the liquid densities of the solvent media. To normalize the activity coefficients, the symmetric convention is adopted. Thermochemical properties of the salt are used to estimate the solubility product. It is shown that the proposed procedure can describe with good accuracy a series of salt...

  15. Chemical reactions in solvents and melts

    CERN Document Server

    Charlot, G

    1969-01-01

    Chemical Reactions in Solvents and Melts discusses the use of organic and inorganic compounds as well as of melts as solvents. This book examines the applications in organic and inorganic chemistry as well as in electrochemistry. Organized into two parts encompassing 15 chapters, this book begins with an overview of the general properties and the different types of reactions, including acid-base reactions, complex formation reactions, and oxidation-reduction reactions. This text then describes the properties of inert and active solvents. Other chapters consider the proton transfer reactions in

  16. Rational Design of Molecular Gelator - Solvent Systems Guided by Solubility Parameters

    Science.gov (United States)

    Lan, Yaqi

    Self-assembled architectures, such as molecular gels, have attracted wide interest among chemists, physicists and engineers during the past decade. However, the mechanism behind self-assembly remains largely unknown and no capability exists to predict a priori whether a small molecule will gelate a specific solvent or not. The process of self-assembly, in molecular gels, is intricate and must balance parameters influencing solubility and those contrasting forces that govern epitaxial growth into axially symmetric elongated aggregates. Although the gelator-gelator interactions are of paramount importance in understanding gelation, the solvent-gelator specific (i.e., H-bonding) and nonspecific (dipole-dipole, dipole-induced and instantaneous dipole induced forces) intermolecular interactions are equally important. Solvent properties mediate the self-assembly of molecular gelators into their self-assembled fibrillar networks. Herein, solubility parameters of solvents, ranging from partition coefficients (logP), to Henry's law constants (HLC), to solvatochromic ET(30) parameters, to Kamlet-Taft parameters (beta, alpha and pi), to Hansen solubility parameters (deltap, deltad, deltah), etc., are correlated with the gelation ability of numerous classes of molecular gelators. Advanced solvent clustering techniques have led to the development of a priori tools that can identify the solvents that will be gelled and not gelled by molecular gelators. These tools will greatly aid in the development of novel gelators without solely relying on serendipitous discoveries.

  17. Bio-based solvents: an emerging generation of fluids for the design of eco-efficient processes in catalysis and organic chemistry.

    Science.gov (United States)

    Gu, Yanlong; Jérôme, François

    2013-12-21

    Biomass and waste exhibit great potential for replacing fossil resources in the production of chemicals. The search for alternative reaction media to replace petroleum-based solvents commonly used in chemical processes is an important objective of significant environmental consequence. Recently, bio-based derivatives have been either used entirely as green solvents or utilized as pivotal ingredients for the production of innovative solvents potentially less toxic and more bio-compatible. This review presents the background and classification of these new media and highlights recent advances in their use in various areas including organic synthesis, catalysis, biotransformation and separation. The greenness, advantages and limitations of these solvents are also discussed.

  18. "Solvent Effects" in 1H NMR Spectroscopy.

    Science.gov (United States)

    Cavaleiro, Jose A. S.

    1987-01-01

    Describes a simple undergraduate experiment in chemistry dealing with the "solvent effects" in nuclear magnetic resonance (NMR) spectroscopy. Stresses the importance of having students learn NMR spectroscopy as a tool in analytical chemistry. (TW)

  19. Solvent Extraction Developments in Southern Africa

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    The largest solvent-extraction plant in the world at the time, the Nchanga Copper Operation, was in Zambia. The first commercial process using solvent extraction for the refining of the platinum-group metals was in South Africa. More recently, the Southern African region has seen the implementation of solvent extraction for other base metals, precious metals, and specialty metals. These include the world firsts of primary production of zinc at Skorpion Zinc in Namibia and the large-scale refining of gold by Harmony Gold in South Africa. Several other flowsheets that use solvent-extraction technology are currently under commissioning, development, or feasibility study for implementation in this part of the world, including those for the recovery of copper, cobalt, nickel, tantalum, and niobium.

  20. Solvent-Free Synthesis of New Coumarins

    Directory of Open Access Journals (Sweden)

    Redah I. Al-Bayati

    2012-01-01

    Full Text Available A solvent-free synthesis of five series of coumarin derivatives using microwave assistant is presented herein. The synthesized compounds are fully characterized by UV-VIS, FT-IR, and NMR spectroscopy.

  1. Water as a Solvent for Life

    Science.gov (United States)

    Pohorille, Andrew; Pratt, Lawrence R.

    2015-01-01

    "Follow the water" is our basic strategy in searching for life in the universe. The universality of water as the solvent for living systems is usually justified by arguing that water supports the rich organic chemistry that seeds life, but alternative chemistries are possible in other organic solvents. Here, other, essential criteria for life that have not been sufficiently considered so far, will be discussed.

  2. Competitive solvent-molecule interactions govern primary processes of diphenylcarbene in solvent mixtures

    Science.gov (United States)

    Knorr, Johannes; Sokkar, Pandian; Schott, Sebastian; Costa, Paolo; Thiel, Walter; Sander, Wolfram; Sanchez-Garcia, Elsa; Nuernberger, Patrick

    2016-10-01

    Photochemical reactions in solution often proceed via competing reaction pathways comprising intermediates that capture a solvent molecule. A disclosure of the underlying reaction mechanisms is challenging due to the rapid nature of these processes and the intricate identification of how many solvent molecules are involved. Here combining broadband femtosecond transient absorption and quantum mechanics/molecular mechanics simulations, we show for one of the most reactive species, diphenylcarbene, that the decision-maker is not the nearest solvent molecule but its neighbour. The hydrogen bonding dynamics determine which reaction channels are accessible in binary solvent mixtures at room temperature. In-depth analysis of the amount of nascent intermediates corroborates the importance of a hydrogen-bonded complex with a protic solvent molecule, in striking analogy to complexes found at cryogenic temperatures. Our results show that adjacent solvent molecules take the role of key abettors rather than bystanders for the fate of the reactive intermediate.

  3. Solvent dependent photophysical properties of dimethoxy curcumin

    Science.gov (United States)

    Barik, Atanu; Indira Priyadarsini, K.

    2013-03-01

    Dimethoxy curcumin (DMC) is a methylated derivative of curcumin. In order to know the effect of ring substitution on photophysical properties of curcumin, steady state absorption and fluorescence spectra of DMC were recorded in organic solvents with different polarity and compared with those of curcumin. The absorption and fluorescence spectra of DMC, like curcumin, are strongly dependent on solvent polarity and the maxima of DMC showed red shift with increase in solvent polarity function (Δf), but the above effect is prominently observed in case of fluorescence maxima. From the dependence of Stokes' shift on solvent polarity function the difference between the excited state and ground state dipole moment was estimated as 4.9 D. Fluorescence quantum yield (ϕf) and fluorescence lifetime (τf) of DMC were also measured in different solvents at room temperature. The results indicated that with increasing solvent polarity, ϕf increased linearly, which has been accounted for the decrease in non-radiative rate by intersystem crossing (ISC) processes.

  4. Influence of solvent polarity on preferential solvation of molecular recognition probes in solvent mixtures.

    Science.gov (United States)

    Amenta, Valeria; Cook, Joanne L; Hunter, Christopher A; Low, Caroline M R; Vinter, Jeremy G

    2012-12-13

    The association constants for formation of 1:1 complexes between a H-bond acceptor, tri-n-butylphosphine oxide, and a H-bond donor, 4-phenylazophenol, have been measured in a range of different solvent mixtures. Binary mixtures of n-octane and a more polar solvent (ether, ester, ketone, nitrile, sulfoxide, tertiary amide, and halogenated and aromatic solvents) have been investigated. Similar behavior was observed in all cases. When the concentration of the more polar solvent is low, the association constant is identical to that observed in pure n-octane. Once a threshold concentration of the more polar solvent in reached, the logarithm of the association constant decreases in direct proportion to the logarithm of the concentration of the more polar solvent. This indicates that one of the two solutes is preferentially solvated by the more polar solvent, and it is competition with this solvation equilibrium that determines the observed association constant. The concentration of the more polar solvent at which the onset of preferential solvation takes place depends on solvent polarity: 700 mM for toluene, 60 mM for 1,1,2,2-tetrachloroethane, 20 mM for the ether, ester, ketone, and nitrile, 0.2 mM for the tertiary amide, and 0.1 mM for the sulfoxide solvents. The results can be explained by a simple model that considers only pairwise interactions between specific sites on the surfaces of the solutes and solvents, which implies that the bulk properties of the solvent have little impact on solvation thermodynamics.

  5. Caustic-Side Solvent Extraction: Chemical and Physical Properties of the Optimized Solvent

    Energy Technology Data Exchange (ETDEWEB)

    Delmau, L.H.

    2002-10-08

    This work was undertaken to optimize the solvent used in the Caustic Side Solvent Extraction (CSSX) process and to measure key chemical and physical properties related to its performance in the removal of cesium from the alkaline high-level salt waste stored in tanks at the Savannah River Site. The need to adjust the solvent composition arose from the prior discovery that the previous baseline solvent was supersaturated with respect to the calixarene extractant. The following solvent-component concentrations in Isopar{reg_sign} L diluent are recommended: 0.007 M calix[4]arene-bis(tert-octylbenzo-crown-6) (BOBCalixC6) extractant, 0.75 M 1-(2,2,3,3-tetrafluoropropoxy)-3-(4-sec-butylphenoxy)-2-propanol (Cs-7SB) phase modifier, and 0.003 M tri-n-octylamine (TOA) stripping aid. Criteria for this selection included BOBCalixC6 solubility, batch cesium distribution ratios (D{sub Cs}), calculated flowsheet robustness, third-phase formation, coalescence rate (dispersion numbers), and solvent density. Although minor compromises within acceptable limits were made in flowsheet robustness and solvent density, significant benefits were gained in lower risk of third-phase formation and lower solvent cost. Data are also reported for the optimized solvent regarding the temperature dependence of D{sub Cs} in extraction, scrubbing, and stripping (ESS); ESS performance on recycle; partitioning of BOBCalixC6, Cs-7SB, and TOA to aqueous process solutions; partitioning of organic anions; distribution of metals; solvent phase separation at low temperatures; solvent stability to elevated temperatures; and solvent density and viscosity. Overall, the technical risk of the CSSX process has been reduced by resolving previously identified issues and raising no new issues.

  6. The use of environmentally sustainable bio-derived solvents in solvent extraction applications-A review

    Institute of Scientific and Technical Information of China (English)

    Zheng Li; Kathryn H. Smith; Geoffrey W. Stevens

    2016-01-01

    Replacement of volatile organic compounds (VOCs) by greener or more environmental y sustainable solvents is becoming increasingly important due to the increasing health and environmental concerns as wel as economic pressures associated with VOCs. Solvents that are derived from biomass, namely bio-derived solvents, are a type of green solvent that have attracted intensive investigations in recent years because of their advantages over con-ventional VOCs, such as low toxicity, biodegradability and renewability. This review aims to summarize the use of bio-derived solvents in solvent extraction applications, with special emphasis given to utilization of biodiesels and terpenes. Compared with the conventional VOCs, the overall performance of these bio-derived solvents is comparable in terms of extraction yields and selectivity for natural product extraction and no difference was found for metal extraction. To date most researchers have focused on laboratory scale thermodynamics studies. Future work is required to develop and test new bio-derived solvents and understand the kinetic performance as well as solvent extraction pilot plant studies.

  7. CHEMICAL STABILITY OF POLYPHENYLENE SULFIDE IN THE NEXT GENERATION SOLVENT FOR CAUSTIC-SIDE SOLVENT EXTRACTION

    Energy Technology Data Exchange (ETDEWEB)

    Fondeur, F.; Fink, S.

    2011-12-08

    The Office of Waste Processing, within the Office of Technology Innovation and Development, is funding the development of an enhanced solvent for deployment at the Savannah River Site for removal of cesium from High Level Waste. For simplicity, this solvent is referred to as the Next Generation Solvent (NGS). The technical effort is collaboration between Oak Ridge National Laboratory (ORNL), Savannah River National Laboratory (SRNL), and Argonne National Laboratory. The initial deployment target envisioned for the technology was within the Modular Caustic-Side Solvent Extraction Unit (MCU). Deployment of a new chemical within an existing facility requires verification that the chemical components are compatible with the installed equipment. In the instance of a new organic solvent, the primary focus is on compatibility of the solvent with polyphenylene sulfide (PPS), the polymer used in the coalescers within MCU. This report provides the data from exposing PPS polymer to NGS. The test was conducted over a three month period. PPS is remarkably stable in the presence of the next generation solvent. Testing showed no indication of swelling or significant leaching. Preferential sorption of the Modifier on PPS was observed but the same behavior occurs with the baseline solvent. Therefore, PPS coalescers exposed to the NGS are expected to perform comparably to those in contact with the baseline solvent.

  8. Influence of Energy on Solvent Diffusion in Polymer/Solvent Systems

    Institute of Scientific and Technical Information of China (English)

    HUHuijun; JIANGWenhua; 等

    2002-01-01

    The Vrentas-Duda free-volume theory has been extensively used to correlate or predict the solvent diffusion coefficient of a polymer/solvent system.The energy term in the free volume diffusion equation is difficult to estimate,so the energy term was usually neglected in previous predictive versions of the free volume diffusion coefficient equation.Recent studies show that the energy effect is very important even above the glass transition temperature of the system. In this paper, a new evaluation method of the energy term is proposed,that is the diffusion energy at different solvent concentrations is assumed to be a linear function of the solvent diffusion energy in pure solvents and that in polymers under the condition that the solvent in infinite dilution.By taking consideration of the influence of energy on the solvent diffustion,the prediction of solvent diffusion coefficient was preformed for three polymer/solvent systems over a wide range of concentrations and temperatures.The results show an improvement on the predictive capability of the free volume diffusion theory.

  9. A novel 9 × 9 map-based solvent selection strategy for targeted counter-current chromatography isolation of natural products.

    Science.gov (United States)

    Liang, Junling; Meng, Jie; Wu, Dingfang; Guo, Mengzhe; Wu, Shihua

    2015-06-26

    Counter-current chromatography (CCC) is an efficient liquid-liquid chromatography technique for separation and purification of complex mixtures like natural products extracts and synthetic chemicals. However, CCC is still a challenging process requiring some special technical knowledge especially in the selection of appropriated solvent systems. In this work, we introduced a new 9 × 9 map-based solvent selection strategy for CCC isolation of targets, which permit more than 60 hexane-ethyl acetate-methanol-water (HEMWat) solvent systems as the start candidates for the selection of solvent systems. Among these solvent systems, there are clear linear correlations between partition coefficient (K) and the system numbers. Thus, an appropriate CCC solvent system (i.e., sweet spot for K = 1) may be hit by measurement of k values of the target only in two random solvent systems. Besides this, surprisingly, we found that through two sweet spots, we could get a line ("Sweet line") where there are infinite sweet solvent systems being suitable for CCC separation. In these sweet solvent systems, the target has the same partition coefficient (K) but different solubilities. Thus, the better sweet solvent system with higher sample solubility can be obtained for high capacity CCC preparation. Furthermore, we found that there is a zone ("Sweet zone") where all solvent systems have their own sweet partition coefficients values for the target in range of 0.4 natural products as standards and further confirmed by isolation of several targets including honokiol and magnolol from the extracts of Magnolia officinalis Rehd. Et Wils and tanshinone IIA from Salvia miltiorrhiza Bunge. In practice, it is much easier to get a suitable solvent system only by making a simple screening two to four HEMWat two-phase solvent systems to obtain the sweet line or sweet zone without special knowledge or comprehensive standards as references. This is an important advancement for solvent system selection

  10. Stability of the Caustic-Side Solvent Extraction (CSSX) Process Solvent: Effect of High Nitrite on Solvent Nitration

    Energy Technology Data Exchange (ETDEWEB)

    Bonnesen, P.V.

    2002-06-26

    The purpose of this investigation was to determine whether nitrated organic compounds could be formed during operation of the Caustic-Side Solvent Extraction (CSSX) process, and whether such compounds would present a safety concern. The CSSX process was developed to remove cesium from alkaline high-level salt waste stored at the US Department of Energy Savannah River Site (SRS). The solvent is composed of the cesium extractant calix[4]arene-bis-(4-tert-octylbenzo-crown-6) (BOBCalixC6), a fluorinated alcohol phase modifier, tri-n-octylamine (TOA), and an isoparaffinic diluent (Iospar{reg_sign}). During the CSSX process, the solvent is expected to be exposed to high concentrations of nitrate and nitrite dissolved in the alkaline waste feed. The solvent will also be exposed to dilute (50 mM) nitric acid solutions containing low concentrations of nitrite during scrubbing, followed by stripping with 1 mM nitric acid. The solvent is expected to last for one year of plant operation, and the temperatures the solvent may experience during the process could range from as low as 15 C to as high as 35 C. Excursions from standard process conditions could result in the solvent experiencing higher temperatures, as well as concentrations of nitrate, nitrite, and most importantly nitric acid, that exceed normal operating conditions. Accordingly, conditions may exist where nitration reactions involving the solvent components, possibly leading to other chemical reactions stemming from nitration reactions, could occur. To model such nitration reactions, the solvent was exposed to the types of nitrate- and nitrite-containing solutions that might be expected to be encountered during the process (even under off-normal conditions), as a function of time, temperature, and concentration of nitrate, nitrite, and nitric acid. The experiments conducted as part of this report were designed to examine the more specific effect that high nitrite concentrations could have on forming nitrated

  11. "I'm the Same Teacher": The Attitudes of Science and Computer Literacy Teachers Regarding Integrating ICT in Instruction to Advance Meaningful Learning

    Science.gov (United States)

    Steiner, Dasi; Mendelovitch, Miriam

    2017-01-01

    The communications revolution reaches all sectors of the population and makes information accessible to all. This development presents complex challenges which require changes in the education system, teaching methods and learning environment. The integration of ICT (Information and Communications Technology) and science teaching requires…

  12. Lipase catalyzed esterification of glycidol in nonaqueous solvents: solvent effects on enzymatic activity.

    Science.gov (United States)

    Martins, J F; de Sampaio, T C; de Carvalho, I B; Barreiros, S

    1994-06-05

    We studied the effect of organic solvents on the kinetics of porcine pancreatic lipase (pp) for the resolution of racemic glycidol through esterification with butyric acid. We quantified ppl hydration by measuring water sorption isotherms for the enzyme in the solvents/mixtures tested. The determination of initial rates as a function of enzyme hydration revealed that the enzyme exhibits maximum apparent activity in the solvents/mixtures at the same water content (9% to 11% w/w) within the associated experimental error. The maximum initial rates are different in all the media and correlate well with the logarithm of the molar solubility of water in the media, higher initial rates being observed in the solvents/mixtures with lower water solubilities. The data for the mixtures indicate that ppl apparent activity responds to bulk property of the solvent. Measurements of enzyme particle sizes in five of the solvents, as function of enzyme hydration, revealed that mean particle sizes increased with enzyme hydration in all the solvents, differences between solvents being more pronounced at enzyme hydration levels close to 10%. At this hydration level, solvents having a higher water content lead to lower reaction rates; these are the solvents where the mean enzyme particle sizes are greater. Calculation of the observable modulus indicates there are no internal diffusion limitations. The observed correlation between changes in initial rates and changes in external surface area of the enzyme particles suggests that interfacial activation of ppl is only effective at the external surface of the particles. Data obtained for the mixtures indicate that ppl enantioselectivity depends on specific solvent-enzyme interactions. We make reference to ppl hydration and activity in supercritical carbon dioxide.

  13. Role of Solvents in Improvement of Dissolution Rate of Drugs: Crystal Habit and Crystal Agglomeration

    Directory of Open Access Journals (Sweden)

    Maryam Maghsoodi

    2015-03-01

    Full Text Available Crystallization is often used for manufacturing drug substances. Advances of crystallization have achieved control over drug identity and purity, but control over the physical form remains poor. This review discusses the influence of solvents used in crystallization process on crystal habit and agglomeration of crystals with potential implication for dissolution. According to literature it has been known that habit modification of crystals by use of proper solvents may enhance the dissolution properties by changing the size, number and the nature of crystal faces exposed to the dissolution medium. Also, the faster dissolution rate of drug from the agglomerates of crystals compared with the single crystals may be related to porous structure of the agglomerates and consequently their better wettability. It is concluded from this review that in-depth understanding of role of the solvents in crystallization process can be applied to engineering of crystal habit or crystal agglomeration, and predictably dissolution improvement in poorly soluble drugs.

  14. PSE For Solvent Applications: A Generic Computer-aided Solvent Selection and Design Framework

    DEFF Research Database (Denmark)

    Mitrofanov, Igor; Sin, Gürkan; Gani, Rafiqul

    Solvents are widely used across a number of industries in many applications such as separation agents, reaction mediums, cleaning agents and product carriers. Selection of optimal solvents in these applications is mostly based on previous experiences and experimental trial and error. A process sy...

  15. The orientation of solvent-dipoles at the surface of the pure solvent

    NARCIS (Netherlands)

    Nedermeijer-Denessen, H.J.M.; Ligny, C.L. de

    1975-01-01

    A method is described for the assessment of the preferential orientation of solvent-dipoles at the surface of the solvent from the surface potential χ and its temperature coefficient, dχ/dT. The method is based on the model of Levine et al. of the Stern inner region at the mercury-water interface in

  16. Chlorinated solvent replacements recycle/recovery review report

    Energy Technology Data Exchange (ETDEWEB)

    Beal, M.; Hsu, D.; McAtee, R.E.; Weidner, J.R. (EG and G Idaho, Inc., Idaho Falls, ID (United States)); Berg, L.; McCandless, F.P.; Waltari, S.; Peterson, C. (Montana State Univ., Bozeman, MT (United States). Dept. of Chemical Engineering)

    1992-08-01

    This report is a literature review of waste solvents recycle/recovery methods and shows the results of solvent separations using membrane and distillation technologies. The experimental solvent recovery methods were conducted on solvent replacements for chlorinated solvents at Montana State University. The literature review covers waste solvents separation using distillation, membranes decantation, filtration, carbon adsorption, solvent extraction, and other vapor-phase separation techniques. The results of this study identify solvent distillation methods as the most common separation technique. The alternative separation methods typically supplement distillation. The study shows the need for industries to identify waste solvent disposal methods and investigate the economics of waste solvent recycling as a possible waste reduction method.

  17. Ion Exchange and Solvent Extraction: Supramolecular Aspects of Solvent Exchange Volume 21

    Energy Technology Data Exchange (ETDEWEB)

    Gloe, Karsten [Technischen Universität Dresden; Tasker, Peter A [ORNL; Oshima, Tatsuya [University of Miyazaki; Watarai, Hitoshi [Institute for NanoScience Design at Osaka University; Nilsson, Mikael [University of California, Irvine

    2013-01-01

    inverse micelles swollen with water molecules. Extraction systems involving long-chain cations such as alkylammonium species or long-chain anions such as sulfonates or carboxylates proved especially prone to extensive aggregate formation. The related phenomenon of third-phase formation in SX systems, long misunderstood, is now yielding to spectroscopic and scattering techniques showing extensive long-range organization. Over the last 50 years, tools for studying the structure and thermodynamics of aggregation have grown increasingly sophisticated, leading to a rich and detailed understanding of what we can now recognize as SC phenomena in SX. In the 1970s and 1980s, the rapid growth of SC elicited a paradigm shift in SX. The influence of SC principles had two major effects on the course of SX research. First, it provided a framework for understanding the supramolecular behavior that was already well appreciated in the field of SX, though earlier without the SC terminology. Second, it provided the conceptual tools to control supramolecular behavior in SX, direct it for intended functionality, and to simplify it. Extraction by designed reagents has been steadily progressing ever since, with commercial applications emerging to successfully validate this approach. With the discovery of crown ethers in the late 1960s, the advancement of extractant design has fruitfully employed the concept of inclusion. While considerable initial progress occurred with such molecules, especially because of their affinity and selectivity for alkali and alkaline earth metals, other molecular platforms such as calixarenes have proven more versatile. Multidentate receptors for partial to full inclusion of cations, anions, ion pairs, as well as neutral species, have now become commonplace for selective extraction. This volume of Ion Exchange and Solvent Extraction examines how the principles of SC are being employed both in advancing the design of new highly selective SX systems and in

  18. Recommended methods for purification of solvents and tests for impurities

    CERN Document Server

    Coetzee, J F

    1982-01-01

    Recommended Methods for Purification of Solvents and Tests for Impurities is a compilation of recommended procedures for purification of solvents and tests for solvent impurities. Ten solvents are covered: acetonitrile, sulfolane, propylene carbonate, dimethyl sulfoxide, dimethylformamide, hexamethylphosphoramide, pyridine, ethylenediamine, N-methylacetamide, and N-methylpropionamide. This book is comprised of 12 chapters and opens with an introduction to general aspects of impurity effects. The rationale for the selection of solvent is explained, and the relative reactivities of solutes in di

  19. To gel or not to gel: correlating molecular gelation with solvent parameters.

    Science.gov (United States)

    Lan, Y; Corradini, M G; Weiss, R G; Raghavan, S R; Rogers, M A

    2015-10-07

    Rational design of small molecular gelators is an elusive and herculean task, despite the rapidly growing body of literature devoted to such gels over the past decade. The process of self-assembly, in molecular gels, is intricate and must balance parameters influencing solubility and those contrasting forces that govern epitaxial growth into axially symmetric elongated aggregates. Although the gelator-gelator interactions are of paramount importance in understanding gelation, the solvent-gelator specific (i.e., H-bonding) and nonspecific (dipole-dipole, dipole-induced and instantaneous dipole induced forces) intermolecular interactions are equally important. Solvent properties mediate the self-assembly of molecular gelators into their self-assembled fibrillar networks. Herein, solubility parameters of solvents, ranging from partition coefficients (log P), to Henry's law constants (HLC), to solvatochromic parameters (ET(30)), and Kamlet-Taft parameters (β, α and π), and to Hansen solubility parameters (δp, δd, δh), are correlated with the gelation ability of numerous classes of molecular gelators. Advanced solvent clustering techniques have led to the development of a priori tools that can identify the solvents that will be gelled and not gelled by molecular gelators. These tools will greatly aid in the development of novel gelators without solely relying on serendipitous discoveries. These tools illustrate that the quest for the universal gelator should be left in the hands of Don Quixote and as researchers we must focus on identifying gelators capable of gelling classes of solvents as there is likely no one gelator capable of gelling all solvents.

  20. Alternative Solvents through Green Chemistry Project

    Science.gov (United States)

    Hintze, Paul E.; Quinn, Jacqueline

    2014-01-01

    Components in the aerospace industry must perform with accuracy and precision under extreme conditions, and surface contamination can be detrimental to the desired performance, especially in cases when the components come into contact with strong oxidizers such as liquid oxygen. Therefore, precision cleaning is an important part of a components preparation prior to utilization in aerospace applications. Current cleaning technologies employ a variety of cleaning agents, many of which are halogenated solvents that are either toxic or cause environmental damage. Thus, this project seeks to identify alternative precision cleaning solvents and technologies, including use of less harmful cleaning solvents, ultrasonic and megasonic agitation, low-pressure plasma cleaning techniques, and supercritical carbon dioxide extraction. Please review all data content found in the Public Data tab located at: https:techport.nasa.govview11697public

  1. Solvent-resistant microporous polymide membranes

    Science.gov (United States)

    Miller, Warren K.; McCray, Scott B.; Friesen, Dwayne T.

    1998-01-01

    An asymmetric microporous membrane with exceptional solvent resistance and highly desirable permeability is disclosed. The membrane is made by a solution-casting or solution-spinning process from a copolyamic acid comprising the condensation reaction product in a solvent of at least three reactants selected from certain diamines and dianhydrides and post-treated to imidize and in some cases cross-link the copolyamic acid. The membrane is useful as an uncoated membrane for ultrafiltration, microfiltration, and membrane contactor applications, or may be used as a support for a permselective coating to form a composite membrane useful in gas separations, reverse osmosis, nanofiltration, pervaporation, or vapor permeation.

  2. Solvent-free fluidic organic dye lasers.

    Science.gov (United States)

    Choi, Eun Young; Mager, Loic; Cham, Tran Thi; Dorkenoo, Kokou D; Fort, Alain; Wu, Jeong Weon; Barsella, Alberto; Ribierre, Jean-Charles

    2013-05-06

    We report on the demonstration of liquid organic dye lasers based on 9-(2-ethylhexyl)carbazole (EHCz), so-called liquid carbazole, doped with green- and red-emitting laser dyes. Both waveguide and Fabry-Perot type microcavity fluidic organic dye lasers were prepared by capillary action under solvent-free conditions. Cascade Förster-type energy transfer processes from liquid carbazole to laser dyes were employed to achieve color-variable amplified spontaneous emission and lasing. Overall, this study provides the first step towards the development of solvent-free fluidic organic semiconducting lasers and demonstrates a new kind of optoelectronic applications for liquid organic semiconductors.

  3. NMR spectroscopy using liquid crystal solvents

    CERN Document Server

    Emsley, JW

    2013-01-01

    NMR Spectroscopy using Liquid Crystal Solvents covers the importance of using a liquid crystal solvent in NMR to derive nuclear dipolar spin-spin coupling constants. This book is composed of ten chapters, and begins with a brief description of the features and benefits of liquid crystal in NMR spectroscopic analysis. The succeeding chapters deal with the mode of operation of nuclear spin Hamiltonian for partially oriented molecules and the analysis of NMR spectra of partially oriented molecules, as well as the determination of rigid molecule structure. These topics are followed by discussions

  4. Occupational exposure to solvents and bladder cancer

    DEFF Research Database (Denmark)

    Hadkhale, Kishor; Martinsen, Jan Ivar; Weiderpass, Elisabete;

    2017-01-01

    logistic regression model was used to estimate hazard ratios (HR) and their 95% confidence intervals (95% CI). Increased risks were observed for trichloroethylene (HR 1.23, 95% 95% CI 1.12-1.40), toluene (HR 1.20, 95% CI 1.00-1.38), benzene (HR 1.16, 95% CI 1.04-1.31), aromatic hydrocarbon solvents (HR 1...... of occupational exposure to trichloroethylene, perchloroethylene, aromatic hydrocarbon solvents, benzene and toluene and the risk of bladder cancer. This article is protected by copyright. All rights reserved....

  5. 局部晚期鼻腔鼻窦胚胎性横纹肌肉瘤的多模式治疗经验%Integrated multimodality therapy for local advanced embryonal rhabdomyosarcoma of nasal cavity and paranasal sinus

    Institute of Scientific and Technical Information of China (English)

    任伟; 闫婧; 殷海涛; 孔炜伟; 钱晓萍; 刘宝瑞

    2011-01-01

    目的 探讨无法手术的原发性局部晚期鼻腔鼻窦胚胎性横纹肌肉瘤的多模式综合治疗.方法对l例无法手术的局部晚期鼻腔鼻窦胚胎性横纹肌肉瘤初治患者,采用术前同步放化疗→手术→术后同步放化疗→辅助化疗的多模式综合治疗,观察治疗效果、不良反应和生活质量情况.结果经多模式综合治疗后患者的症状、体征完全消失,局部肿瘤病灶接近完全缓解,不良反应可耐受,患者容貌恢复正常.随访至2011年3月,患者仍无病生存中,生活质量佳,可正常工作.结论无法手术的局部晚期鼻腔鼻窦胚胎性横纹肌肉瘤通过多模式综合治疗近期疗效好,症状显著缓解,生活质量提高,生存期延长.%Objective To investigate integrated multimodality comprehensive therapy for inoperable primary locally advanced embryonal rhabdomyosarcoma of the nasal cavity and paranasal sinus. Methods One newly diagnostic adolescent patient with inoperable locally advanced embryonal rhabdomyosarcoma of the nasal cavity and paranasal sinus was treated with integrated multimodality comprehensive therapy of preoperative concurrently chemoradiotherapy-+surgery operation-?postoperative concurrently chemoradiothera-py-?adjuvant chemotherapy. The therapeutic effect, adverse effect and quality of life were investigated. Results The symptom and physical sign of the patient was all disappear,and the local tumor nearly reached complete response after the treatment with tolerable adverse effects. The facial feature of the patient recovery absolutely normal again. Until March 2011, the patient was currently disease-free with very good quality of life and normal job. Conclusion The integrated multimodality comprehensive therapy for the patients with inoperable locally advanced embryonal rhabdomyosarcoma of the nasal cavity and paranasal sinus can obviously release the clinical symptom , protect the patient's feature, improve quality of life, and

  6. Integration of advanced geoscience and engineering techniques to quantify interwell heterogeneity in reservoir models. Final report, September 29, 1993--September 30, 1996

    Energy Technology Data Exchange (ETDEWEB)

    Weiss, W.W.; Buckley, J.S.; Ouenes, A.

    1997-05-01

    The goal of this three-year project was to provide a quantitative definition of reservoir heterogeneity. This objective was accomplished through the integration of geologic, geophysical, and engineering databases into a multi-disciplinary understanding of reservoir architecture and associated fluid-rock and fluid-fluid interactions. This interdisciplinary effort integrated geological and geophysical data with engineering and petrophysical results through reservoir simulation to quantify reservoir architecture and the dynamics of fluid-rock and fluid-fluid interactions. An improved reservoir description allows greater accuracy and confidence during simulation and modeling as steps toward gaining greater recovery efficiency from existing reservoirs. A field laboratory, the Sulimar Queen Unit, was available for the field research. Several members of the PRRC staff participated in the development of improved reservoir description by integration of the field and laboratory data as well as in the development of quantitative reservoir models to aid performance predictions. Subcontractors from Stanford University and the University of Texas at Austin (UT) collaborated in the research and participated in the design and interpretation of field tests. The three-year project was initiated in September 1993 and led to the development and application of various reservoir description methodologies. A new approach for visualizing production data graphically was developed and implemented on the Internet. Using production data and old gamma rays logs, a black oil reservoir model that honors both primary and secondary performance was developed. The old gamma ray logs were used after applying a resealing technique, which was crucial for the success of the project. In addition to the gamma ray logs, the development of the reservoir model benefitted from an inverse Drill Stem Test (DST) technique which provided initial estimates of the reservoir permeability at different wells.

  7. Unmanned Aircraft Systems (UAS) Integration in the National Airspace System (NAS) Project: Advanced Collision Avoidance System for UAS (ACAS Xu) Interoperability White Paper Presentation

    Science.gov (United States)

    Fern, Lisa

    2017-01-01

    The Phase 1 DAA Minimum Operational Performance Standards (MOPS) provided requirements for two classes of DAA equipment: equipment Class 1 contains the basic DAA equipment required to assist a pilot in remaining well clear, while equipment Class 2 integrates the Traffic Alert and Collision Avoidance (TCAS) II system. Thus, the Class 1 system provides RWC functionality only, while the Class 2 system is intended to provide both RWC and Collision Avoidance (CA) functionality, in compliance with the Minimum Aviation System Performance (MASPS) for the Interoperability of Airborne Collision Avoidance Systems. The FAAs TCAS Program Office is currently developing Airborne Collision Avoidance System X (ACAS X) to support the objectives of the Federal Aviation Administrations (FAA) Next Generation Air Transportation System Program (NextGen). ACAS X has a suite of variants with a common underlying design that are intended to be optimized for their intended airframes and operations. ACAS Xu being is designed for UAS and allows for new surveillance technologies and tailored logic for platforms with different performance characteristics. In addition to Collision Avoidance (CA) alerting and guidance, ACAS Xu is being tuned to provide RWC alerting and guidance in compliance with the SC 228 DAA MOPS. With a single logic performing both RWC and CA functions, ACAS Xu will provide industry with an integrated DAA solution that addresses many of the interoperability shortcomings of Phase I systems. While the MOPS for ACAS Xu will specify an integrated DAA system, it will need to show compliance with the RWC alerting thresholds and alerting requirements defined in the DAA Phase 2 MOPS. Further, some functional components of the ACAS Xu system such as the remote pilots displayed guidance might be mostly references to the corresponding requirements in the DAA MOPS. To provide a seamless, integrated, RWC-CA system to assist the pilot in remaining well clear and avoiding collisions, several

  8. Integration of a Higher Plant Chamber into the European Space Agency's MELiSSA Pilot Plant: The Canadian Role in Advanced Life Support Test-Bed Development

    Science.gov (United States)

    Waters, Geoffrey; Lawson, Jamie; Gidzinski, Danuta; Stasiak, Michael; Dixon, Mike; Peiro, Enrique; Godia, Francesc; Paille, Christel; Fossen, Arnaud; Lamaze, Brigitte; Lasseur, Christophe

    The European Space Agency's Micro-Ecological Life Support System Alternative (MELiSSA) project has been conceived as a tool for developing the technology of future biological life support systems required for long-term human space exploration missions to the Moon or Mars. The main life support functions of MELiSSA are the recycling of waste (inedible plant biomass, human excrement), carbon dioxide and minerals and the production of food, fresh water and air revitalization. Based on the principle of an aquatic ecosystem, MELiSSA is comprised of four microbial compartments and a higher plant compartment integrated in a closed loop. Each compartment is studied, designed and demonstrated at laboratory scale before being scaled-up for subsequent integration into the MELISSA Pilot Plant (MPP) at the Universitat Aut`noma de Barcelona. Work related to higher plant cultivation systems, o which have been historically focussed at the University of Guelph's Controlled Environment Systems Research Facility (CESRF), has included design of the HPC for the MPP, the metabolic characterization of MELiSSA candidate crops and the validation of theoretical gas exchange and nutrient dynamic models, The presented paper will review some of the recent data and HPC design work of CESRF conducted as part of Canada's involvement in the MELiSSA program and its partnership in the development of the MPP terrestrial demonstration test-bed.

  9. Grid integration of electric-powered vehicles in existing and future energy supply structures. Advances in systems analyses 1. Final report; Netzintegration von Fahrzeugen mit elektrifizierten Antriebssystemen in bestehende und zukuenftige Energieversorgungsstrukturen. Advances in System Analyses 1. Endbericht

    Energy Technology Data Exchange (ETDEWEB)

    Linssen, Jochen; Bickert, Stefan; Hennings, Wilfried [Forschungszentrum Juelich GmbH (Germany). Inst. fuer Energie- und Klimaforschung, Systemforschung und Technologische Entwicklung (IEK-STE)] [and others

    2012-07-01

    The research project examines whether a fleet of vehicles with electric propulsion system (xEV) can be integrated into existing and future energy supply systems for effective integration of fluctuating power production as well as for energy storage. A multi-sectoral, system-wide scenario analysis is performed to evaluate the grid integration of electric vehicles. The effect of an xEV fleet and the impacts of various battery charging scenarios, including the option of feeding power back into the grid, are addressed by detailed technical and economic models and summarized by an energy system model. The suitability of different powertrain concepts is analysed, giving consideration to their individual applications by users. Based on the results of a German nationwide survey of mobility patterns and analyses of 47 test subjects, individual driving profiles for private cars are drawn up and stored in a database. They are used as input for the vehicle energy model. This model calculates the energy requirements of different xEV concepts and facilitates optimized powertrain design and battery sizing for the respective applications. The results show that if the batteries are charged overnight it is possible to cover a major fraction of daily driving distances by electric power. Additional charging during the day does not significantly improve this fraction. The auxiliaries have a greater influence on the vehicle's energy demand than individual driving patterns. Battery lifetime is extended by recharging the battery as required and preferably as late as possible before the next trip. In most cases, using the batteries for grid services reduces battery lifetime and leads to higher specific costs. Models of the transmission grid and typical distribution grids are developed. It is shown that charging one million xEV in 2020 and six million in 2030 (as envisaged by the German Federal Government) is technically feasible without major structural modifications of the

  10. Grid integration of electric-powered vehicles in existing and future energy supply structures. Advances in systems analyses 1. Final report; Netzintegration von Fahrzeugen mit elektrifizierten Antriebssystemen in bestehende und zukuenftige Energieversorgungsstrukturen. Advances in System Analyses 1. Endbericht

    Energy Technology Data Exchange (ETDEWEB)

    Linssen, Jochen; Bickert, Stefan; Hennings, Wilfried [Forschungszentrum Juelich GmbH (Germany). Inst. fuer Energie- und Klimaforschung, Systemforschung und Technologische Entwicklung (IEK-STE)] [and others

    2012-07-01

    The research project examines whether a fleet of vehicles with electric propulsion system (xEV) can be integrated into existing and future energy supply systems for effective integration of fluctuating power production as well as for energy storage. A multi-sectoral, system-wide scenario analysis is performed to evaluate the grid integration of electric vehicles. The effect of an xEV fleet and the impacts of various battery charging scenarios, including the option of feeding power back into the grid, are addressed by detailed technical and economic models and summarized by an energy system model. The suitability of different powertrain concepts is analysed, giving consideration to their individual applications by users. Based on the results of a German nationwide survey of mobility patterns and analyses of 47 test subjects, individual driving profiles for private cars are drawn up and stored in a database. They are used as input for the vehicle energy model. This model calculates the energy requirements of different xEV concepts and facilitates optimized powertrain design and battery sizing for the respective applications. The results show that if the batteries are charged overnight it is possible to cover a major fraction of daily driving distances by electric power. Additional charging during the day does not significantly improve this fraction. The auxiliaries have a greater influence on the vehicle's energy demand than individual driving patterns. Battery lifetime is extended by recharging the battery as required and preferably as late as possible before the next trip. In most cases, using the batteries for grid services reduces battery lifetime and leads to higher specific costs. Models of the transmission grid and typical distribution grids are developed. It is shown that charging one million xEV in 2020 and six million in 2030 (as envisaged by the German Federal Government) is technically feasible without major structural modifications of the

  11. Solvent tuned single molecule dual emission in protic solvents: effect of polarity and H-bonding.

    Science.gov (United States)

    Chevreux, S; Allain, C; Wilbraham, L; Nakatani, K; Jacques, P; Ciofini, I; Lemercier, G

    2015-01-01

    Phen-PENMe2 has recently been proposed as a promising new molecule displaying solvent-tuned dual emission, highlighting an original and newly-described charge transfer model. The study of the photophysical behaviour of this molecule was extended to include protic solvents. The effects of polarity and hydrogen bonding lead to an even more evident dual emission associated with a large multi-emission band in some solvents like methanol, highlighting Phen-PENMe2 as a promising candidate for white light emission.

  12. Used Solvent Testing and Reclamation. Volume 2. Vapor Degreasing and Precision Cleaning Solvents

    Science.gov (United States)

    1988-12-01

    Dependence of the 1,3-Dioxolane/AlCI 3 Reaction Using Arrhenius’ Law 88 36 Effect of 1,4-Dioxane on Reactor Pressure 91 67 Effect of 1,4-Dioxane on HCI...and spent solvent. This process was performed for all of the three solvents. Inhibitor Kinetic Studies Batch Reactions. Batch reactor kinetic studies...acceptor in chlorinated solvents. It is an 4 80. Levenspiel , Chemical Reaction Engineering, 2nd ed. (John Wiley and Sons, 1972), pp 41-86. 490

  13. Mixed Solvent Reactive Recrystallization of Sodium Carbonate

    NARCIS (Netherlands)

    Gaertner, R.S.

    2005-01-01

    Investigation of the reactive recrystallization of trona (sodium sesquicarbonate) and sodium bicarbonate to sodium carbonate (soda) in a mixed solvent led to the design of several alternative, less energy consumptive, economically very attractive process routes for the production of soda from all pr

  14. ESES: Software for Eulerian solvent excluded surface.

    Science.gov (United States)

    Liu, Beibei; Wang, Bao; Zhao, Rundong; Tong, Yiying; Wei, Guo-Wei

    2017-03-15

    Solvent excluded surface (SES) is one of the most popular surface definitions in biophysics and molecular biology. In addition to its usage in biomolecular visualization, it has been widely used in implicit solvent models, in which SES is usually immersed in a Cartesian mesh. Therefore, it is important to construct SESs in the Eulerian representation for biophysical modeling and computation. This work describes a software package called Eulerian solvent excluded surface (ESES) for the generation of accurate SESs in Cartesian grids. ESES offers the description of the solvent and solute domains by specifying all the intersection points between the SES and the Cartesian grid lines. Additionally, the interface normal at each intersection point is evaluated. Furthermore, for a given biomolecule, the ESES software not only provides the whole surface area, but also partitions the surface area according to atomic types. Homology theory is utilized to detect topological features, such as loops and cavities, on the complex formed by the SES. The sizes of loops and cavities are measured based on persistent homology with an evolutionary partial differential equation-based filtration. ESES is extensively validated by surface visualization, electrostatic solvation free energy computation, surface area and volume calculations, and loop and cavity detection and their size estimation. We used the Amber PBSA test set in our electrostatic solvation energy, area, and volume validations. Our results are either calibrated by analytical values or compared with those from the MSMS software. © 2017 Wiley Periodicals, Inc.

  15. Solvent-Free Synthesis of Chalcones

    Science.gov (United States)

    Palleros, Daniel R.

    2004-01-01

    The synthesis of twenty different chalcones in the absence of solvent is presented. The results indicated that out of the twenty different chalcones investigated seventeen can be obtained in a matter of minutes by mixing the corresponding benzaldehyde and acetophenone in the presence of solid NaOH in a mortar with pestle.

  16. Computer-Aided Solvent Screening for Biocatalysis

    DEFF Research Database (Denmark)

    Abildskov, Jens; Leeuwen, M.B. van; Boeriu, C.G.;

    2013-01-01

    . Esterification of acrylic acid with octanol is also addressed. Solvents are screened and candidates identified, confirming existing experimental results. Although the examples involve lipases, the method is quite general, so there seems to be no preclusion against application to other biocatalysts....

  17. Organic solvent nanofiltration: prospects and application

    Energy Technology Data Exchange (ETDEWEB)

    Volkov, A V; Korneeva, G A; Tereshchenko, Gennadii F [A. V. Topchiev Institute of Petrochemical Synthesis, Russian Academy of Sciences, Moscow (Russian Federation)

    2008-11-30

    The key lines of research in a new field of the membrane science and technology, viz., organic solvent nanofiltration, are considered. The prospects for its use in chemical, petrochemical and food industries are discussed. Attention is focused on membranes developed for this method.

  18. Organic solvents in electromembrane extraction: recent insights

    DEFF Research Database (Denmark)

    Huang, Chuixiu; Gjelstad, Astrid; Pedersen-Bjergaard, Stig

    2016-01-01

    Electromembrane extraction (EME) was invented in 2006 as a miniaturized sample preparation technique for the separation of ionized species from aqueous samples. This concept has been investigated in different areas of analytical chemistry by different research groups worldwide since the introduct......Electromembrane extraction (EME) was invented in 2006 as a miniaturized sample preparation technique for the separation of ionized species from aqueous samples. This concept has been investigated in different areas of analytical chemistry by different research groups worldwide since...... the introduction. Under the influence of an electrical field, EME is based on electrokinetic migration of the analytes through a supported liquid membrane (SLM), which is an organic solvent immobilized in the pores of the polymeric membrane, and into the acceptor solution. Up to date, close to 150 research...... articles with focus on EME have been published. The current review summarizes the performance of EME with different organic solvents and discusses several criteria for efficient solvents in EME. In addition, the authors highlight their personal perspective about the most promising organic solvents for EME...

  19. Selective solvent absorption in coal conversion

    Energy Technology Data Exchange (ETDEWEB)

    Larsen, J.W.; Lapucha, A.; Lazarov, L.; Amui, J.

    1992-04-01

    The objectives of this project are: (1) to determine the importance of the presence of added hydrogen donor compounds within the coal in the first stage of direct liquefaction processes; and (2) to determine the composition of the solvent absorbed by and present within the coal in the first stage of direct coal liquefaction.

  20. Axiomatic Characterizations of the Choquet Integral

    DEFF Research Database (Denmark)

    Groes, Ebbe; Whitta-Jacobsen, Hans Jørgen; Sloth, Birgitte;

    The Choquet integral is an integral part of recent advances in decision theory involving non-additive measures. In this article we present two new axiomatic characterizations of this functional......The Choquet integral is an integral part of recent advances in decision theory involving non-additive measures. In this article we present two new axiomatic characterizations of this functional...

  1. 外来入侵豚草综合治理研究进展%Cai-taiAdvances in Integrated Control of Invasive Alien Plant Ambrosia artemisiifolia

    Institute of Scientific and Technical Information of China (English)

    王娟; 邓旭; 谭济才

    2011-01-01

    Ambrosia is a kind of invasive alien weed, whose invasion not only threatens native biodiversity and ecosystems, but also causes considerable economic loss. In order to control the damage of Ambrosia effectively, on the basis of introducing mechanical, chemical and biological control methods, the insufficiencies of them were clarified and an integrated control measure was proposed.%豚草属(Ambrosia)是一种外来恶性杂草,它的入侵不仅威胁了当地生物多样性和生态系统,还导致巨大的经济损失.为有效控制其危害,在介绍豚草人工、化学、生物控制方法的基础上,针对各种方法不足之处.提出了综合控制措施.

  2. Effect of yield to tensile (Y/T) ratio on the structural integrity of offshore pipeline: advanced engineering assessment using limit state design approach

    Energy Technology Data Exchange (ETDEWEB)

    Malatesta, G.; Mannucci, G.; Demofonti, G. [Centro Sviluppo Materiali S.p.A., Rome (Italy); Cumino, G. [TenarisDalmine (Italy); Izquierdo, A.; Tivelli, M. [Tenaris Group (Mexico); Quintanilla, H. [TENARIS Group (Mexico). TAMSA

    2005-07-01

    Nowadays specifications require strict Yield to Tensile ratio limitation, nevertheless a fully accepted engineering assessment of its influence on pipeline integrity is still lacking. Probabilistic analysis based on structural reliability approach (Limit State Design) aimed at quantifying the Y/T ratio influence on failure probabilities of offshore pipelines was made. In particular, Tenaris seamless pipe data were used as input for the probabilistic failure analysis. The LSD approach has been applied to two actual deep water design cases that have been on purpose selected, and the most relevant failure modes have been considered. Main result of the work is that the quantitative effect of the Y/T ratio on failure probabilities of a deep water pipeline resulted not so big as expected; it has a minor effect, especially when failure modes are governed by Y only. (author)

  3. Advancing the Integration of Population Medicine into Medical Curricula at The Warren Alpert Medical School of Brown University: A New Master's Degree Program.

    Science.gov (United States)

    Mello, Michael J; Feller, Edward; George, Paul; Borkan, Jeffrey

    2015-09-01

    Additional knowledge, attitudes and skills are required for the next generation of medical students as they expand the traditional focus on individual patients to include population-based health and scholarly investigation. The Warren Alpert Medical School of Brown University (AMS) is initiating a master's degree program as a key component of the new Primary Care-Population Medicine program at AMS leading to both a Doctorate in Medicine (MD) and Master of Science in Population Medicine (ScM) degrees in four years. The ScM is composed of a series of nine courses, integrated into the four-year MD curriculum, as well as a thesis. Additional attention will be given to leadership and quality improvement training. The goal is to produce graduates competent in the care of individual patients, panels, communities, and populations.

  4. Designing an advanced available-to-promise mechanism compatible with the make-to-forecast production systems through integrating inventory allocation and job shop scheduling with due dates and weighted earliness/tardiness cost

    Directory of Open Access Journals (Sweden)

    Masoud Rabbani

    2016-06-01

    Full Text Available In the competitive business world, applying a reliable and powerful mechanism to support decision makers in manufacturing companies and helping them save time by considering varieties of effective factors is an inevitable issue. Advanced Available-to-Promise is a perfect tool to design and perform such a mechanism. In this study, this mechanism which is compatible with the Make-to-Forecast production systems is presented. The ability to distinguish between batch mode and real-time mode advanced available-to-promise is one of the unique superiorities of the proposed model. We also try to strengthen this mechanism by integrating the inventory allocation and job shop scheduling by considering due dates and weighted earliness/tardiness cost that leads to more precise decisions. A mixed integer programming (MIP model and a heuristic algorithm according to its disability to solve large size problems are presented. The designed experiments and the obtained results have proved the efficiency of the proposed heuristic method.

  5. Manufacturing technology supported by advanced and integrated information system through international cooperation in fiscal 1995; Kan`i sosagata denshi sekkei seisan shien system no kaihatsu ni kansuru kenkyu kyoryoku

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-03-01

    Informatization using mainly computers is more and more important contributing to the upgrading in society, economy and a variety of fields. As to informatization in developing countries, however, there has still been few to be seen. Accordingly, gaps are getting larger between developing countries and developed countries where informatization is acceleratedly advanced. In the light of such actual state, Center of the International Cooperation for Computerization (CICC) contracted with NEDO and promoted a project `Manufacturing technology supported by advanced and integrated information system through international cooperation.` This is a project to study jointly with five Asian countries with which NEDO made a basic contract, China, Indonesia, Malaysia, Singapore and Thailand. Working group is set up for each theme such as automobiles/parts, electric home appliances/parts, and fiber/apparel, to study the construction of a model house and the design of a system. In fiscal 1994, the field survey was conducted, and in fiscal 1995 the system design was started. 16 figs., 1 tab.

  6. Research cooperation project on manufacturing technology supported by advanced and integrated information system through international cooperation (MATIC); Kan`i sosagata denshi sekkei seisan shien system no kaihatsu ni kansuru kenkyu kyoryoku

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-03-01

    To support the advancement of basic industries including machine industry in Asian countries, research cooperation has been conducted for developing the manufacturing technology supported by advanced and integrated information system suitable for actual circumstances of individual countries. For the automotive and the parts industries, it is significant for the preparation works of manufacturing in overseas factories to possess common information between Japan and overseas factories. In this project, a system is constructed, which can be used in industries surrounding automotive industry, such as parts and facility industries, as well as in the automotive industry. In FY 1996, a primary system has been developed, and the demonstration tests were carried out. For the home electric machine and the parts industries, the technology applicable to the design of printed board circuit was developed, and the catalog of electronic parts was constructed. In FY 1996, a preliminary prototype system of the electronic parts catalog system was designed and developed. For the textile and apparel industries, the EDI, exchange system of CAD/CAM data, and construction of data bank were investigated. 87 figs., 19 tabs.

  7. Recent advances in the Lesser Antilles observatories Part 2 : WebObs - an integrated web-based system for monitoring and networks management

    Science.gov (United States)

    Beauducel, François; Bosson, Alexis; Randriamora, Frédéric; Anténor-Habazac, Christian; Lemarchand, Arnaud; Saurel, Jean-Marie; Nercessian, Alexandre; Bouin, Marie-Paule; de Chabalier, Jean-Bernard; Clouard, Valérie

    2010-05-01

    Seismological and Volcanological observatories have common needs and often common practical problems for multi disciplinary data monitoring applications. In fact, access to integrated data in real-time and estimation of measurements uncertainties are keys for an efficient interpretation, but instruments variety, heterogeneity of data sampling and acquisition systems lead to difficulties that may hinder crisis management. In Guadeloupe observatory, we have developed in the last years an operational system that attempts to answer the questions in the context of a pluri-instrumental observatory. Based on a single computer server, open source scripts (Matlab, Perl, Bash, Nagios) and a Web interface, the system proposes: an extended database for networks management, stations and sensors (maps, station file with log history, technical characteristics, meta-data, photos and associated documents); a web-form interfaces for manual data input/editing and export (like geochemical analysis, some of the deformation measurements, ...); routine data processing with dedicated automatic scripts for each technique, production of validated data outputs, static graphs on preset moving time intervals, and possible e-mail alarms; computers, acquisition processes, stations and individual sensors status automatic check with simple criteria (files update and signal quality), displayed as synthetic pages for technical control. In the special case of seismology, WebObs includes a digital stripchart multichannel continuous seismogram associated with EarthWorm acquisition chain (see companion paper Part 1), event classification database, location scripts, automatic shakemaps and regional catalog with associated hypocenter maps accessed through a user request form. This system leads to a real-time Internet access for integrated monitoring and becomes a strong support for scientists and technicians exchange, and is widely open to interdisciplinary real-time modeling. It has been set up at

  8. Development of an Integrated Multi-Contaminant Removal Process Applied to Warm Syngas Cleanup for Coal-Based Advanced Gasification Systems

    Energy Technology Data Exchange (ETDEWEB)

    Meyer, Howard

    2010-11-30

    This project met the objective to further the development of an integrated multi-contaminant removal process in which H2S, NH3, HCl and heavy metals including Hg, As, Se and Cd present in the coal-derived syngas can be removed to specified levels in a single/integrated process step. The process supports the mission and goals of the Department of Energy's Gasification Technologies Program, namely to enhance the performance of gasification systems, thus enabling U.S. industry to improve the competitiveness of gasification-based processes. The gasification program will reduce equipment costs, improve process environmental performance, and increase process reliability and flexibility. Two sulfur conversion concepts were tested in the laboratory under this project, i.e., the solventbased, high-pressure University of California Sulfur Recovery Process High Pressure (UCSRP-HP) and the catalytic-based, direct oxidation (DO) section of the CrystaSulf-DO process. Each process required a polishing unit to meet the ultra-clean sulfur content goals of <50 ppbv (parts per billion by volume) as may be necessary for fuel cells or chemical production applications. UCSRP-HP was also tested for the removal of trace, non-sulfur contaminants, including ammonia, hydrogen chloride, and heavy metals. A bench-scale unit was commissioned and limited testing was performed with simulated syngas. Aspen-Plus®-based computer simulation models were prepared and the economics of the UCSRP-HP and CrystaSulf-DO processes were evaluated for a nominal 500 MWe, coal-based, IGCC power plant with carbon capture. This report covers the progress on the UCSRP-HP technology development and the CrystaSulf-DO technology.

  9. High frequency of loss of allelic integrity at Wilms′ tumor suppressor gene-1 locus in advanced breast tumors associated with aggressiveness of the tumor

    Directory of Open Access Journals (Sweden)

    S Gupta

    2009-01-01

    Full Text Available Background: The product of Wilms′ tumor suppressor gene (WT1, a nuclear transcription factor, regulates the expression of the insulin-like growth factor (IGF and transforming growth factor (TGF systems, both of which are implicated in breast tumorigenesis and are known to facilitate angiogenesis. In the present study, WT1 allelic integrity was examined by Loss of Heterozygosity (LOH studies in infiltrating breast carcinoma (n=60, ductal carcinoma in situ (DCIS (n=10 and benign breast disease (n=5 patients, to determine its possible association with tumor progression. Methods: LOH at the WT1 locus (11p13 as determined by PCR-RFLP for Hinf1 restriction site and was subsequently examined for its association with intratumoral expression of various growth factors i.e. TGF-β1, IGF-II, IGF-1R and angiogenesis (VEGF and Intratumoral micro-vessel density in breast carcinoma. Results: Six of 22 (27.2% genetically heterozygous of infiltrating breast carcinoma and 1 of 4 DCIS cases showed loss of one allele at WT1 locus. Histologically, the tumors with LOH at WT1 were Intraductal carcinoma (IDC and were of grade II and III. There was no correlation in the appearance of LOH at WT1 locus with age, tumor stage, menopausal status, chemotherapy status and lymph node metastasis. The expression of factor IGF-II and its receptor, IGF-1R was significantly higher in carcinoma having LOH at WT1 locus. A positive correlation was observed between the TGF-β1, VEGF expression and IMD scores in infiltrating carcinoma. Conclusions: The current study indicates that the high frequency of loss of allelic integrity at Wilms′ tumor suppressor gene-1 locus in high-graded breast tumors is associated with aggressiveness of the tumor.

  10. Development and Integration of an Advanced Stirling Convertor Linear Alternator Model for a Tool Simulating Convertor Performance and Creating Phasor Diagrams

    Science.gov (United States)

    Metscher, Jonathan F.; Lewandowski, Edward J.

    2013-01-01

    A simple model of the Advanced Stirling Convertors (ASC) linear alternator and an AC bus controller has been developed and combined with a previously developed thermodynamic model of the convertor for a more complete simulation and analysis of the system performance. The model was developed using Sage, a 1-D thermodynamic modeling program that now includes electro-magnetic components. The convertor, consisting of a free-piston Stirling engine combined with a linear alternator, has sufficiently sinusoidal steady-state behavior to allow for phasor analysis of the forces and voltages acting in the system. A MATLAB graphical user interface (GUI) has been developed to interface with the Sage software for simplified use of the ASC model, calculation of forces, and automated creation of phasor diagrams. The GUI allows the user to vary convertor parameters while fixing different input or output parameters and observe the effect on the phasor diagrams or system performance. The new ASC model and GUI help create a better understanding of the relationship between the electrical component voltages and mechanical forces. This allows better insight into the overall convertor dynamics and performance.

  11. Final report for %22High performance computing for advanced national electric power grid modeling and integration of solar generation resources%22, LDRD Project No. 149016.

    Energy Technology Data Exchange (ETDEWEB)

    Reno, Matthew J.; Riehm, Andrew Charles; Hoekstra, Robert John; Munoz-Ramirez, Karina; Stamp, Jason Edwin; Phillips, Laurence R.; Adams, Brian M.; Russo, Thomas V.; Oldfield, Ron A.; McLendon, William Clarence, III; Nelson, Jeffrey Scott; Hansen, Clifford W.; Richardson, Bryan T.; Stein, Joshua S.; Schoenwald, David Alan; Wolfenbarger, Paul R.

    2011-02-01

    Design and operation of the electric power grid (EPG) relies heavily on computational models. High-fidelity, full-order models are used to study transient phenomena on only a small part of the network. Reduced-order dynamic and power flow models are used when analysis involving thousands of nodes are required due to the computational demands when simulating large numbers of nodes. The level of complexity of the future EPG will dramatically increase due to large-scale deployment of variable renewable generation, active load and distributed generation resources, adaptive protection and control systems, and price-responsive demand. High-fidelity modeling of this future grid will require significant advances in coupled, multi-scale tools and their use on high performance computing (HPC) platforms. This LDRD report demonstrates SNL's capability to apply HPC resources to these 3 tasks: (1) High-fidelity, large-scale modeling of power system dynamics; (2) Statistical assessment of grid security via Monte-Carlo simulations of cyber attacks; and (3) Development of models to predict variability of solar resources at locations where little or no ground-based measurements are available.

  12. SU-E-T-126: Dosimetric Comparisons of VMAT, IMRT and 3DCRT for Locally Advanced Rectal Cancer with Simultaneous Integrated Boost

    Energy Technology Data Exchange (ETDEWEB)

    Zhao, J; Wang, J; Zhang, Z; Hu, W [Fudan University Shanghai Caner Center, Shanghai, Shanghai (China)

    2014-06-01

    Purpose: The purpose of this study is to compare the dosimetric differences among volumetric modulated arc therapy (VMAT), fixed-field intensity modulated radiotherapy (IMRT) and three-dimensional conformal radiotherapy (3D-CRT) for the preoperative locally advanced rectal cancer (LARC). Methods: Ten LARC patients treated in our department using the simultaneous escalate strategy were retrospectively analyzed in this study. All patients had T3 with N+/− and were treated with IMRT. Two additional VMAT and 3DCRT plans were created for each patient. Both IMRT and VMAT had similar optimization objectives. The prescription was 50Gy to the PTV and 55Gy to the GTV. The target coverage and organs at risk were compared for all the techniques.The paired, two-tailed Wilcoxcon signed-rank test was applied for statistical analysis. Results: IMRT and VMAT plans achieved comparable tumor response except for the conformality index (1.07 vs 1.19 and 1.08 vs 1.03 of IMRT vs VMAT for PTV-G and PTV-C respectively). Compared to VMAT, IMRT showed superior or similar dose sparing in the small bowel, bladder, femoral head. Both IMRT and VMAT had better organs at risk sparing and homogeneity index of PTV-G. Conclusion: All 3DCRT, IMRT and VMAT meet the prescript. The IMRT and VMAT provided comparable dosemitric parameters for target volume. IMRT shows better sparing for small bowel, bladder, femoral heads and normal tissue to 3DCRT and VMAT.

  13. Regolith and Environment Science and Oxygen and Lunar Volatile Extraction (RESOLVE): Lunar Advanced Volatile Analysis (LAVA) Integration and Testing - Evaluation of Lee Valve

    Science.gov (United States)

    Bower, Hannah; Cryderman, Kate; Captain, Janine

    2016-01-01

    The Resource Prospector (RP) mission with the Regolith and Environment Science and Oxygen and Lunar Volatile Extraction (RESOLVE) payload will prospect for water within the lunar regolith and provide a proof of concept for In-Situ Resource Utilization (ISRU) techniques, which could be used on future lunar and Martian missions. One system within the RESOLVE payload is the Lunar Advanced Volatiles Analysis (LAVA) subsystem, which consists of a Fluid Sub System (FSS) that transports volatiles to the Gas Chromatograph-Mass Spectrometer (GC-MS) instrument. In order for the FSS to transport precise and accurate amounts of volatiles to the GC-MS instrumentation, high performance valves are used within the system. The focus of this investigation is to evaluate the redesigned Lee valve. Further work is needed to continue to evaluate the Lee valve. Initial data shows that the valve could meet our requirements however further work is required to raise the TRL to an acceptable level to be included in the flight design of the system. At this time the risk is too high to change our baseline design to include these non-latching Lee solenoid valves.

  14. 积分运算中一题多解诌议%Comment of Advanced-solution to a Math Problem in Integrated Operation

    Institute of Scientific and Technical Information of China (English)

    程书红

    2012-01-01

    It is prevalent and regular that an advanced math question has more than one answer in calculus. To foster the ability of diverging thinking and awareness of creation, emphasis should be laid on the training of giving more answers to a question,in which attention be paid to the combina- tion of basic answering ways and specific methods, as well as to the exploration of the common issues and particular ones between those methods.%在微积分中,一题多解的可能性经常存在,并且有规律可循。为培养学生发散性思维能力和创新意识,应加强一题多解的训练,其中更应着眼于一般解题思想方法与具体技巧的结合,要深入考查和探讨解题方法之间的共同点与特殊性。

  15. Development of an integrated approach for α-pinene recovery and sugar production from loblolly pine using ionic liquids

    DEFF Research Database (Denmark)

    Papa, Gabriella; Kirby, James; Murthy Konda, N. V. S. N.

    2017-01-01

    perspective for the production of advanced cellulosic biofuels. To date, there have been very few examples where a single conversion process has enabled recovery of both terpenes and fermentable sugars in an integrated fashion. We have used the ionic liquid (IL), 1-ethyl-3-methylimidazolium acetate [C2C1Im......][OAc] at 120 °C and 160 °C in conjunction with analytical protocols using GC-MS, to extract α-pinene and simultaneously pretreat the pine to generate high yields of fermentable sugars after saccharification. Compared to solvent extraction, the IL process enabled higher recovery rates for α-pinene, from three...

  16. Solvent density mode instability in non-polar solutions

    Indian Academy of Sciences (India)

    Susmita Kar; Ranjit Biswas; J Chakrabarti

    2008-08-01

    We analyse the origin of the multiple long time scales associated with the long time decay observed in non-polar solvation dynamics by linear stability analysis of solvent density modes where the effects of compressibility and solvent structure are systematically incorporated. The coupling of the solute–solvent interactions at both ground and excited states of the solute with the compressibility and solvent structure is found to have important effects on the time scales. The present theory suggests that the relatively longer time constant is controlled by the solvent compressibility, while the solvent structure at the nearest-neighbour length scale dominates the shorter time constant.

  17. Analog filtering of large solvent signals for improved dynamic range in high-resolution NMR.

    Science.gov (United States)

    Redfield, A G; Kunz, S D

    1998-01-01

    The large solvent signal from samples in H2O solvent still challenges the dynamic range capability of any spectrometer. The solvent signal can be largely removed with a pair of simple resistor-capacitor (RC) high-pass filters when the solvent frequency is set at center band (zero frequency) using quadrature detection, with RC approximately 0.5 ms. However, an approximately 0.5-ms transient remains at initial time, which we reduce fourfold for a short time only, just before the A/D converter, by means of a variable-gain amplifier, and later restore with software. This modification can result in a nearly fourfold increase in dynamic range. When we converted to a frequency-shifted mode (A. G. Redfield and S. D. Kunz, 1994, J. Magn. Reson. A 108, 234-237) we replaced the RC high-pass filter with a quadrature feedback notch filter tuned to the solvent frequency (5.06 kHz). This filter is an example of a class of two-input/two-output filters which maintain the spectral integrity (image-free character) of quadrature signals. Digital filters of the same type are also considered briefly. We discuss the implications of these ideas for spectrometer input design, including schemes for elimination of radiation damping, and effects of probe bandwidth on extreme oversampling.

  18. Enhanced sampling and applications in protein folding in explicit solvent

    CERN Document Server

    Zhang, Cheng

    2010-01-01

    We report a single-copy tempering method for enhancing sampling in simulating large complex systems. A continuous temperature space random walk is achieved by a Langevin equation, which is guided by a runtime estimate of the thermal average energy through a novel integral identity. We first validated the method in a two-dimensional Ising model and a Lennard-Jones liquid system. Then the method was applied to folding of three small proteins, trpzip2, trp-cage, and villin headpiece in explicit solvent. Within 0.5~1 microsecond, all three systems were folded into atomic accuracy: the alpha carbon root mean square deviation of the best folded conformations from the native states are 0.2 A, 0.4 A, and 0.4 A, for trpzip2, trp-cage, and villin headpiece, respectively.

  19. Treatment of an actual slaughterhouse wastewater by integration of biological and advanced oxidation processes: Modeling, optimization, and cost-effectiveness analysis.

    Science.gov (United States)

    Bustillo-Lecompte, Ciro Fernando; Mehrvar, Mehrab

    2016-11-01

    Biological and advanced oxidation processes are combined to treat an actual slaughterhouse wastewater (SWW) by a sequence of an anaerobic baffled reactor, an aerobic activated sludge reactor, and a UV/H2O2 photoreactor with recycle in continuous mode at laboratory scale. In the first part of this study, quadratic modeling along with response surface methodology are used for the statistical analysis and optimization of the combined process. The effects of the influent total organic carbon (TOC) concentration, the flow rate, the pH, the inlet H2O2 concentration, and their interaction on the overall treatment efficiency, CH4 yield, and H2O2 residual in the effluent of the photoreactor are investigated. The models are validated at different operating conditions using experimental data. Maximum TOC and total nitrogen (TN) removals of 91.29 and 86.05%, respectively, maximum CH4 yield of 55.72%, and minimum H2O2 residual of 1.45% in the photoreactor effluent were found at optimal operating conditions. In the second part of this study, continuous distribution kinetics is applied to establish a mathematical model for the degradation of SWW as a function of time. The agreement between model predictions and experimental values indicates that the proposed model could describe the performance of the combined anaerobic-aerobic-UV/H2O2 processes for the treatment of SWW. In the final part of the study, the optimized combined anaerobic-aerobic-UV/H2O2 processes with recycle were evaluated using a cost-effectiveness analysis to minimize the retention time, the electrical energy consumption, and the overall incurred treatment costs required for the efficient treatment of slaughterhouse wastewater effluents.

  20. Advance care directives

    Science.gov (United States)

    ... advance directive; Do-not-resuscitate - advance directive; Durable power of attorney - advance care directive; POA - advance care directive; Health care agent - advance care directive; Health care proxy - ...

  1. Integrated, systems metabolic picture of acetone-butanol-ethanol fermentation by Clostridium acetobutylicum.

    Science.gov (United States)

    Liao, Chen; Seo, Seung-Oh; Celik, Venhar; Liu, Huaiwei; Kong, Wentao; Wang, Yi; Blaschek, Hans; Jin, Yong-Su; Lu, Ting

    2015-07-07

    Microbial metabolism involves complex, system-level processes implemented via the orchestration of metabolic reactions, gene regulation, and environmental cues. One canonical example of such processes is acetone-butanol-ethanol (ABE) fermentation by Clostridium acetobutylicum, during which cells convert carbon sources to organic acids that are later reassimilated to produce solvents as a strategy for cellular survival. The complexity and systems nature of the process have been largely underappreciated, rendering challenges in understanding and optimizing solvent production. Here, we present a system-level computational framework for ABE fermentation that combines metabolic reactions, gene regulation, and environmental cues. We developed the framework by decomposing the entire system into three modules, building each module separately, and then assembling them back into an integrated system. During the model construction, a bottom-up approach was used to link molecular events at the single-cell level into the events at the population level. The integrated model was able to successfully reproduce ABE fermentations of the WT C. acetobutylicum (ATCC 824), as well as its mutants, using data obtained from our own experiments and from literature. Furthermore, the model confers successful predictions of the fermentations with various network perturbations across metabolic, genetic, and environmental aspects. From foundation to applications, the framework advances our understanding of complex clostridial metabolism and physiology and also facilitates the development of systems engineering strategies for the production of advanced biofuels.

  2. Integrating an Advanced Technological Research Centre in its Social Environment. Results of a Psycho-Social Research; El Centro de Tecnologias Avanzadas de El Bierzo y su Integracion en el Entorno Social. Resultados de la Investigacion Psico-Social

    Energy Technology Data Exchange (ETDEWEB)

    Sola, R.; Prades, A.; Espluga, J.; Real, M.

    2006-07-01

    This Report illustrates the main results of a research on citizen's perceptions and expectations regarding the siting of a Research Centre of Advanced Technologies in Spain, notably in the Bierzo area. The aims were to examine the needs and preferences in terms of public Information and communication processes; to explore the risks and benefits that the public links to the centre; and to analyse the hypothetical expectations of citizen participation in the long-term control of the Technological Research Centre. A singular methodological strategy integrating quantitative and qualitative techniques was implemented to achieve these aims. This methodological approach allows not only an in-depth knowledge of the social reality, but also the generation of hypotheses and theoretical knowledge about risk management and perception, and the role of trust in the social acceptance of technologies. Conclusions underline the importance of carrying out psychosocial studies in the hosting area to properly address the idiosyncrasy of the region, as well as the local population concerns, preferences and capabilities to better integrate technological installations in their social context, and to improve the social efficiency of technology. (Author) 6 refs.

  3. 复合型人才需求下的高校日语教学——以听力教学为例%University Japanese Language Teaching under the Need of Integrated Advanced Talents

    Institute of Scientific and Technical Information of China (English)

    单瑜阳

    2011-01-01

    为了满足社会对复合型外语人才的需求,高校日语听力课程需要不断改革。本文通过分析日语听力的难点和听力课现存的问题,结合日语固有特点,提出通过利用精读课文训练听力,介绍口语特有的缩略音现象,场景专题训练,掌握做题技巧等方式,力求有效地提高听力教学效果。%In order to meet the society's need for integrated advanced talents of foreign languages, the listening classes for Japanese language in the universities are required to reform consistently. By analyzing difficulties and problems in Japanese listening classes and integrating the innate characteristics of Japanese language, this article brings up the idea of improving students'listening competence through intensive reading studies, abbreviated pronunciation analysis in oral Japanese, situational training and skills training. With all these methods, the teaching effect can be improved dramatically.

  4. Advanced router architectures

    CERN Document Server

    Kloth, Axel K

    2005-01-01

    Routers, switches, and transmission equipment form the backbone of the Internet, yet many users and service technicians do not understand how these nodes really work.Advanced Router Architectures addresses how components of advanced routers work together and how they are integrated with each other. This book provides the background behind why these building blocks perform certain functions, and how the function is implemented in general use. It offers an introduction to the subject matter that is intended to trigger deeper interest from the reader. The book explains, for example, why traffic m

  5. Advanced Surface Technology

    DEFF Research Database (Denmark)

    Møller, Per; Nielsen, Lars Pleht

    This new significant book on advanced modern surface technology in all its variations, is aimed at both teaching at engineering schools and practical application in industry. The work covers all the significant aspects of modern surface technology and also describes how new advanced techniques make......, nitriding, carbonitriding, and many other lesser-known thermochemical processes used for solving technological problems. The book is richly illustrated with pictures and figures showing how the technology creates new innovative solutions for industry and how surfaces are becoming integral to the function...

  6. Integration of Known Transcription Factor Binding Site Information and Gene Expression Data to Advance from Co-Expression to Co-Regulation

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The common approach to find co-regulated genes is to cluster genes based on gene expression. However, due to the limited information present in any dataset, genes in the same cluster might be co-expressed but not necessarily co-regulated. In this paper, we propose to integrate known transcription factor binding site informa tion and gene expression data into a single clustering scheme. This scheme will find clusters of co-regulated genes that are not only expressed similarly under the measured conditions, but also share a regulatory structure that may explain their common regulation. We demonstrate the utility of this approach on a microarray dataset of yeast grown under different nutrient and oxygen limitations. Our in tegrated clustering method not only unravels many regulatory modules that are consistent with current biological knowledge, but also provides a more profound understanding of the underlying process. The added value of our approach, compared with the clustering solely based on gene expression, is its ability to uncover clusters of genes that are involved in more specific biological processes and are evidently regulated by a set of transcription factors.

  7. Integrating 3D Flower-Like Hierarchical Cu2NiSnS4 with Reduced Graphene Oxide as Advanced Anode Materials for Na-Ion Batteries.

    Science.gov (United States)

    Yuan, Shuang; Wang, Sai; Li, Lin; Zhu, Yun-hai; Zhang, Xin-bo; Yan, Jun-min

    2016-04-13

    Development of an anode material with high performance and low cost is crucial for implementation of next-generation Na-ion batteries (NIBs) electrode, which is proposed to meet the challenges of large scale renewable energy storage. Metal chalcogenides are considered as promising anode materials for NIBs due to their high theoretical capacity, low cost, and abundant sources. Unfortunately, their practical application in NIBs is still hindered because of low conductivity and morphological collapse caused by their volume expansion and shrinkage during Na(+) intercalation/deintercalation. To solve the daunting challenges, herein, we fabricated novel three-dimensional (3D) Cu2NiSnS4 nanoflowers (CNTSNs) as a proof-of-concept experiment using a facile and low-cost method. Furthermore, homogeneous integration with reduced graphene oxide nanosheets (RGNs) endows intrinsically insulated CNTSNs with superior electrochemical performances, including high specific capacity (up to 837 mAh g(-1)), good rate capability, and long cycling stability, which could be attributed to the unique 3D hierarchical structure providing fast ion diffusion pathway and high contact area at the electrode/electrolyte interface.

  8. On the Role of Integrated Team Training in Advancing University Student's Professional Competence%关于“综合团队训练”提升大学生职业能力的研究

    Institute of Scientific and Technical Information of China (English)

    滕云

    2012-01-01

    This paper aims at assessing the role of integrated team training in advancing the professional competence of university students. Altogether 60 freshmen participated in the one-year-long "integrated team training" program, with other 217 university students of the same major and grade as the control group. The results of candidates' responses to the Eureka Skills Inventory Questionnaire before and after the program was initiated showed that candidates did experience remarkable improvement in their competence at self-management and dealing with details, communicative skills, interpersonal relationship, as well as leadership skills. Therefore, it was concluded that integrated team training could significantly enhance university students' professional competence and deserve well of popularization.%本研究以同专业同年级的其他217名学生为参照,针对60名大一学生实施为期一年的“综合团队训练”方案。通过方案实施前后学生们在(EUREKA技能问卷》的测评结果,验证“综合团队训练”在提高大学生职业能力方面的作用。结果显示,参训学生在自我管理、处理细节的能力、沟通技能、人际交往技能、领导技能等方面明显提高。所以,“综合团队训练”能显著提高大学生的职业能力,具有推广价值。

  9. Thermal dosimetry analysis combined with patient-specific thermal modeling of clinical interstitial ultrasound hyperthermia integrated within HDR brachytherapy for treatment of locally advanced prostate cancer

    Science.gov (United States)

    Salgaonkar, Vasant A.; Wootton, Jeff; Prakash, Punit; Scott, Serena; Hsu, I. C.; Diederich, Chris J.

    2017-03-01

    This study presents thermal dosimetry analysis from clinical treatments where ultrasound hyperthermia (HT) was administered following high-dose rate (HDR) brachytherapy treatment for locally advanced prostate cancer as part of a clinical pilot study. HT was administered using ultrasound applicators from within multiple 13-g brachytherapy catheters implanted along the posterior periphery of the prostate. The heating applicators were linear arrays of sectored tubular transducers (˜7 MHz), with independently powered array elements enabling energy deposition with 3D spatial control. Typical heat treatments employed time-averaged peak acoustic intensities of 1 - 3 W/cm2 and lasted for 60 - 70 minutes. Throughout the treatments, temperatures at multiple points were monitored using multi-junction thermocouples, placed within available brachytherapy catheters throughout mid-gland prostate and identified as the hyperthermia target volume (HTV). Clinical constraints allowed placement of 8 - 12 thermocouple sensors in the HTV and patient-specific 3D thermal modeling based on finite element methods (FEM) was used to supplement limited thermometry. Patient anatomy, heating device positions, orientations, and thermometry junction locations were obtained from patient CT scans and HDR and hyperthermia planning software. The numerical models utilized the applied power levels recorded during the treatments. Tissue properties such as perfusion and acoustic absorption were varied within physiological ranges such that squared-errors between measured and simulated temperatures were minimized. This data-fitting was utilized for 6 HT treatments to estimate volumetric temperature distributions achieved in the HTV and surrounding anatomy devoid of thermocouples. For these treatments, the measured and simulated T50 values in the hyperthermia target volume (HTV) were between 40.1 - 43.9 °C and 40.3 - 44.9 °C, respectively. Maximum temperatures between 46.8 - 49.8 °C were measured during

  10. Selection and evaluation of alternative solvents for caprolactam extraction

    NARCIS (Netherlands)

    Delden, van Mathijs L.; Kuipers, Norbert J.M.; Haan, de André B.

    2006-01-01

    Because of the strict legislation for currently applied solvents in the industrial extraction of caprolactam, being benzene, toluene and chlorinated hydrocarbons, a need exists for alternative, environmentally benign solvents. An experimental screening procedure consisting of several steps was used

  11. Effect of solvents on propylene epoxidation over TS-1 catalyst

    Institute of Scientific and Technical Information of China (English)

    Yulong WU; Qingshan LIU; Xueli SU; Zhentao MI

    2008-01-01

    Solvents have an important effect on the epoxidation of propylene catalyzed by TS-1. The experimental results show that, in different solvents, the catalytic activity of epoxidation is in the following order: methanol > 2-propanol > 2-butanol > acetoni-trile > acetone > tetrahydrofuran. Based on the reaction mechanism, the effects of solvents on the epoxidation were studied from eight aspects, which included the electronic effect, the steric effect, the polarity of solvent, the effect of solvent on sorption and diffusion of reactant, the oxidation of alcohol, the etherification of PO, the deactivation of TS-1 and the solubility of propylene in the solvents. The electronic effect, steric effect and the polarity of solvent were considered to be the main aspects. This work may provide theoretical guidance for choosing solvents for these kinds of reactions and also may serve as basis for further industrialization.

  12. The Ideal Solvent for Paper Chromatography of Food Dyes.

    Science.gov (United States)

    Markow, Peter G.

    1988-01-01

    Uses paper chromatography with food dyes to provide a simple and inexpensive basis for teaching chromatography. Provides experimental methodology and tabled results. Includes a solvent system comparison (Rf) for seven dyes and twenty-two solvents. (MVL)

  13. Occupational exposure to chlorinated and petroleum solvents and mycosis fungoides

    DEFF Research Database (Denmark)

    Morales-Suárez-Varela, Maria M; Olsen, Jørn; Villeneuve, Sara;

    2013-01-01

    To evaluate the potential association between occupational exposure to chlorinated and petroleum solvents and mycosis fungoides (MF).......To evaluate the potential association between occupational exposure to chlorinated and petroleum solvents and mycosis fungoides (MF)....

  14. Organic Solvent Tropical Report [SEC 1 and 2

    Energy Technology Data Exchange (ETDEWEB)

    COWLEY, W.L.

    2000-06-21

    This report provides the basis for closing the organic solvent safety issue. Sufficient information is presented to conclude that risk posed by an unmitigated organic solvent fire is within risk evaluation guidelines.

  15. Advancing Land-Sea Conservation Planning: Integrating Modelling of Catchments, Land-Use Change, and River Plumes to Prioritise Catchment Management and Protection.

    Science.gov (United States)

    Álvarez-Romero, Jorge G; Pressey, Robert L; Ban, Natalie C; Brodie, Jon

    2015-01-01

    study demonstrates a practical approach to integrating models of catchments, land-use change, and river plumes with conservation planning software to inform prioritisation of catchment management.

  16. 橄榄加工技术和综合利用研究进展%Advances in Processing Technology and Integrated Utilization of Chinese Olive

    Institute of Scientific and Technical Information of China (English)

    任思琪; 蒋璇靓; 林艺芬; 张珅; 林河通

    2015-01-01

    Chinese olive [Canarium album (Lour.)Raeusch],a special subtropical fruit in South China, has high nutritional and medicinal values.In order to promote the development of Chinese olive industry,and improved the standard of processing technology and integrated utilization of Chinese olive.The cultivation and distribution,fruit quality characteristics of Chinese olive,traditional processing products of Chinese olive fruit including salted Chinese olive and Chinese olive preserved fruit,new types of processing products of Chinese olive fruit like Chinese olive juice,Chinese olive-tea,Chinese olive oral liquid and Chinese olive chewable tab-let,functional components of Chinese olive including polyphenol,flavonoid and fatty acid,and the by-product development of Chinese olive leaf and Chinese olive nucleolus are comprehensively introduced in this paper.%橄榄是中国南方特色亚热带水果,具有丰富的营养价值和药用价值。为促进橄榄产业发展,提高橄榄加工技术和综合利用水平,就橄榄生产分布与果实品质特性,咸橄榄、橄榄蜜饯等传统橄榄加工产品,橄榄汁、橄榄茶、橄榄口服液、橄榄咀嚼片等橄榄新型加工产品,橄榄多酚、类黄酮、脂肪酸等功能性成分及橄榄叶、橄榄核仁等副产物开发利用的研究进展进行综述。

  17. Intensity modulated radiation therapy with simultaneous integrated boost based dose escalation on neoadjuvant chemoradiation therapy for locally advanced distal esophageal adenocarcinoma

    Institute of Scientific and Technical Information of China (English)

    Ming Zeng; Fernando N Aguila; Taral Patel; Mark Knapp; XueQiang Zhu; XiLin Chen; Phillip D Price

    2016-01-01

    AIM:To evaluate impact of radiation therapy dose escalation through intensity modulated radiation therapy with simultaneous integrated boost(IMRT-SIB).METHODS:We retrospectively reviewed the patients who underwent four-dimensional-based IMRT-SIBbased neoadjuvant chemoradiation protocol.During the concurrent chemoradiation therapy,radiation therapy was through IMRT-SIB delivered in 28 consecutive daily fractions with total radiation doses of 56 Gy to tumor and 5040 Gy dose-painted to clinical tumor volume,with a regimen at the discretion of the treating medical oncologist.This was followed by surgical tumor resection.We analyzed pathological completion response(p CR) rates its relationship with overall survival and event-freesurvival.RESULTS:Seventeen patients underwent dose escalation with the IMRT-SIB protocol between 2007 and 2014 and their records were available for analysis.Among the IMRT-SIB-treated patients,the toxicity appeared mild,the most common side effects were grade 1-3 esophagitis(46%) and pneumonitis(11.7%).There were no cardiac events.The Ro resection rate was 94%(n = 16),the p CR rate was 47%(n = 8),and the postoperative morbidity was zero.There was one mediastinal failure found,one patient had local failure at the anastomosis site,and the majority of failures were distant in the lung or bone.The 3-year diseasefree survival and overall survival rates were 41%(n = 7) and 53%(n = 9),respectively.CONCLUSION:The dose escalation through IMRT-SIB in the chemoradiation regimen seems responsible for down-staging the distal esophageal with well-tolerated complications.

  18. Advances in air pollution abatement. Production-integrated emission reduction and waste gas cleaning. Proceedings; Fortschritte in der Luftreinhaltetechnik. Produktionsintegrierte Emissionsminderung und Abgasreinigung. Tagungsband

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2002-07-01

    Conferences on emission reduction have been held by the Kommission Reinhaltung der Luft im VDI and the DIN-Normenausschuss KRdL since 1960. Recent European regulations as well as the TA Luft 2002 set the current boundary conditions. They necessitate that primary measures, i.e. measures integrated in the production process, must be fully utilized. Examples are presented and discussed. As a rule, the exhaust purification systems must be improved as well. This colloquium presented improvements and new developments that were successfully tested in practice and have become an established state-of-the-art technology. This proceedings volume contains the papers read at the colloquium of 19/20 November 2002, in Fulda, as well as the long versions of the posters presented there. [German] Seit 1960 werden von der Kommission Reinhaltung der Luft im VDI und DIN - Normenausschuss KRdL regelmaessig Veranstaltungen durchgefuehrt, um ueber die Fortschritte in der Luftreinhaltetechnik, insbesondere bei Verfahren zur Emissionsminderung von Schadstoffen aus industriellen und gewerblichen Prozessen, zu berichten. Neben den europaeischen Rahmenbedingungen fuer den Umweltschutz stellt die TA Luft 2002 neue Anforderungen an emissionsmindernde Massnahmen. Um die geforderten verringerten Emissionswerte zu erreichen, muessen die Moeglichkeiten des produktionsintegrierten Umweltschutzes ('primaere Massnahmen') vorab ausgeschoepft werden. Beispiele fuer produktionsintegrierte Loesungen zur Emissionsminderung werden vorgestellt und diskutiert. In der Regel sind verfahrenstechnische Verbesserungen der Abgasreinigungsanlagen zusaetzlich unumgaenglich. Zentrales Anliegen des Kolloquiums ist es, die Verbesserungen und Neuentwicklungen des gesamten Spektrums der Emissionsminderung vorzustellen, die mit Erfolg in der Praxis eingefuehrt wurden und sich als Stand der Technik etabliert haben. Der vorliegende Tagungsband enthaelt die Vortraege, die anlaesslich des Kolloquiums &apos

  19. A solvent/non-solvent system for achieving solution-processed multilayer organic light-emitting devices

    Energy Technology Data Exchange (ETDEWEB)

    Yu, Yue; Wu, Zhaoxin, E-mail: zhaoxinwu@mail.xjtu.edu.cn; He, Lin; Jiao, Bo; Hou, Xun

    2015-08-31

    We developed a solvent/non-solvent system to fabricate the multilayer organic light-emitting devices (OLEDs) based on poly(N-vinylcarbazole) (PVK) by solution-process. This solvent system consists of both the solvent and non-solvent of PVK, in which fluorescent small molecules could be fully dissolved and directly spin-coated on top of the PVK layer; it could effectively avoid the redissolution of PVK during the spin-coating process of small molecules emitting layer. In the further investigation of this system, we also demonstrated the three-component solvent system, and found out that the third component, a less volatile solvent of PVK, was crucial for preparing a smoother interface between PVK and emitting layer. Compared with OLEDs through the vacuum deposition, the devices fabricated by solution-process from the solvent/non-solvent system showed comparable efficiency, which indicate that the solvent/non-solvent system can be used as an alternative process to prepare the polymer and small molecule multilayer devices through all-solution-process. - Highlights: • We fabricate the multilayer OLEDs by solution-process using a novel system. • We develop a solvent/non-solvent system of polymer (PVK) to avoid redissolution. • Small molecules could be fully dissolved and directly spin-coated on PVK layer. • The devices fabricated by the system and vacuum deposition show comparable efficiency.

  20. NMR microscopy of tissue in organic and mixed solvents

    OpenAIRE

    Macura Slobodan; Mishra Prasanna K.; Gamez Jeffrey D.; Pirko Istvan

    2013-01-01

    We propose to use organic and mixed solvents for nuclear magnetic resonance microscopy of fixed tissue as a means for improving image information content. NMR properties of some standard solvents (methanol, acetone, DMSO) and solvents in use for tissue processing in pathology (xylenes, paraffin, ‘Clearify’) have been measured, reviewed, and analyzed. It was found that DMSO and paraffin are very useful solvents that provide images of better quality than thos...