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Sample records for advanced direct contact

  1. Geysers advanced direct contact condenser research

    Energy Technology Data Exchange (ETDEWEB)

    Henderson, J.; Bahning, T.; Bharathan, D.

    1997-12-31

    The first geothermal application of the Advanced Direct Contact Condenser (ADCC) technology developed by the National Renewable Energy Laboratory (NREL) is now operational and is being tested at The Geysers Power Plant Unit 11. This major research effort is being supported through the combined efforts of NREL, The Department of Energy (DOE), and Pacific Gas and Electric (PG&E). NREL and PG&E have entered into a Cooperative Research And Development Agreement (CRADA) for a project to improve the direct-contact condenser performance at The Geysers Power Plant. This project is the first geothermal adaptation of an advanced condenser design developed for the Ocean Thermal Energy Conversion (OTEC) systems. PG&E expects this technology to improve power plant performance and to help extend the life of the steam field by using steam more efficiently. In accordance with the CRADA, no money is transferred between the contracting parties. In this case the Department of Energy is funding NREL for their efforts in this project and PG&E is contributing funds in kind. Successful application of this technology at The Geysers will provide a basis for NREL to continue to develop this technology for other geothermal and fossil power plant systems.

  2. Advance Directives

    Science.gov (United States)

    ... Caring Connections is a national consumer and community engagement program of NHPCO that works to improve care ... Institutes of Health FOLLOW US Facebook Twitter Instagram YouTube Google+ LinkedIn GovDelivery RSS CONTACT INFORMATION Contact Us ...

  3. Direct contact condensation in packed beds

    Energy Technology Data Exchange (ETDEWEB)

    Li, Yi; Klausner, James F.; Mei, Renwei; Knight, Jessica [Department of Mechanical and Aerospace Engineering, University of Florida, Gainesville, FL 32611 (United States)

    2006-12-15

    A diffusion driven desalination process was recently described where a very effective direct contact condenser with a packed bed is used to condense water vapor out of an air/vapor mixture. A laboratory scale direct contact condenser has been fabricated as a twin tower structure with two stages, co-current and countercurrent. Experiments have been operated in each stage with respective saturated air inlet temperatures of 36, 40 and 43{sup o}C. The temperature and humidity data have been collected at the inlet and exit of the packed bed for different water to air mass flow ratios that vary between 0 and 2.5. A one-dimensional model based on conservation principles has been developed, which predicts the variation of temperature, humidity, and condensation rate through the condenser stages. Agreement between the model and experiments is very good. It is observed that the countercurrent flow stage condensation effectiveness is significantly higher than that for the co-current stage. The condensation heat and mass transfer rates were found to decrease when water blockages occur within the packed bed. Using high-speed digital cinematography, it was observed that this problem can occur at any operating condition, and is dependent on the packing surface wetting characteristics. This observation is used to explain the requirement for two different empirical constants, depending on packing diameter, suggested by Onda for the air side mass transfer coefficient correlation. (author)

  4. Modeling and simulation of direct contact evaporators

    Directory of Open Access Journals (Sweden)

    Campos F.B.

    2001-01-01

    Full Text Available A dynamic model of a direct contact evaporator was developed and coupled to a recently developed superheated bubble model. The latter model takes into account heat and mass transfer during the bubble formation and ascension stages and is able to predict gas holdup in nonisothermal systems. The results of the coupled model, which does not have any adjustable parameter, were compared with experimental data. The transient behavior of the liquid-phase temperature and the vaporization rate under quasi-steady-state conditions were in very good agreement with experimental data. The transient behavior of liquid height was only reasonably simulated. In order to explain this partial disagreement, some possible causes were analyzed.

  5. Dementia, death and advance directives.

    Science.gov (United States)

    Wolff, Jonathan

    2012-10-01

    This article considers the ethics of advance directives, especially in relation to conditions such as dementia. For some choices, such as over whether one's life should end at home or in a hospice, advance directives can be very enlightened and helpful. For others, such as those to end the life of an autonomous subject, against their will, have no moral appeal and would rightly be ignored. In a wide range of intermediate cases, given our typical lack of insight into how changes in our health condition will affect us in other ways, we should be very cautious indeed in promoting the use of advance directives in end-of-life decisions, at least where a reasonable quality of life remains. There may be some reasons for giving priority to the earlier autonomous self over a later, contented but non-autonomous self, but these reasons seem far from compelling. PMID:23079306

  6. Dementia, death and advance directives.

    OpenAIRE

    Wolff, J.

    2012-01-01

    This article considers the ethics of advance directives, especially in relation to conditions such as dementia. For some choices, such as over whether one's life should end at home or in a hospice, advance directives can be very enlightened and helpful. For others, such as those to end the life of an autonomous subject, against their will, have no moral appeal and would rightly be ignored. In a wide range of intermediate cases, given our typical lack of insight into how changes in our health ...

  7. Applying Directed Graph Theory to Faculty Contact Structure.

    Science.gov (United States)

    House, Ernest R.; Long, John M.

    Although recent writings indicate the importance of personal contact structures in diffusing innovations and in determining perceptions, the internal contact structure of the school faculty remains unexamined. This study applies directed graph theory, a new branch of mathematics, to analyzing school contact structure. Sociometric data and…

  8. Direct measurement of graphene contact resistivity to pre-deposited metal in buried contact test structure

    KAUST Repository

    Qaisi, Ramy M.

    2013-08-01

    We demonstrate a buried contact based novel test structure for direct contact resistivity measurement of graphene-metal interfaces. We also observe excellent contact resistivity 1 μO-cm2 without any additional surface modification suggesting that the intrinsic Au-graphene contact is sufficient for achieving devices with low contact resistance. The chemical mechanical polishing less test structure and data described herein highlights an ideal methodology for systematic screening and engineering of graphene-metal contact resistivity to enable low power high speed carbon electronics. © 2013 IEEE.

  9. Steamdrive direct contact steam generation for SAGD

    Energy Technology Data Exchange (ETDEWEB)

    Betzer-Zilevitch, Maoz [Society of Petroleum Engineers (Canada)

    2011-07-01

    Recently, focus has been shifted from the traditional once-through steam generator (OTSG) to the use of an evaporator and industrial high-pressure (HP) steam boilers in steam assisted gravity drainage (SAGD) steam generation technologies. As a result, the temperatures and pressures attainable are significantly higher than required for injection. This excess steam enthalpy drives the novel steam generation method presented in this paper. The process generates additional steam from highly contaminated oily water with zero liquid waste discharge using industrial boiler superheated steam. The process generates tailor-made pressure and temperature steam required for injection into the underground oil bearing formation. An additional 8-24% steam can be generated from highly contaminated oily water as is seen from the simulation results. The amount of additional steam generated is directly proportional to the temperature of the driving steam and the decrease in pressure of the formation.

  10. Method and apparatus for high-efficiency direct contact condensation

    Energy Technology Data Exchange (ETDEWEB)

    Bharathan, Desikan (Lakewood, CO); Parent, Yves (Golden, CO); Hassani, A. Vahab (Golden, CO)

    1999-01-01

    A direct contact condenser having a downward vapor flow chamber and an upward vapor flow chamber, wherein each of the vapor flow chambers includes a plurality of cooling liquid supplying pipes and a vapor-liquid contact medium disposed thereunder to facilitate contact and direct heat exchange between the vapor and cooling liquid. The contact medium includes a plurality of sheets arranged to form vertical interleaved channels or passageways for the vapor and cooling liquid streams. The upward vapor flow chamber also includes a second set of cooling liquid supplying pipes disposed beneath the vapor-liquid contact medium which operate intermittently in response to a pressure differential within the upward vapor flow chamber. The condenser further includes separate wells for collecting condensate and cooling liquid from each of the vapor flow chambers. In alternate embodiments, the condenser includes a cross-current flow chamber and an upward flow chamber, a plurality of upward flow chambers, or a single upward flow chamber. The method of use of the direct contact condenser of this invention includes passing a vapor stream sequentially through the downward and upward vapor flow chambers, where the vapor is condensed as a result of heat exchange with the cooling liquid in the contact medium. The concentration of noncondensable gases in the resulting condensate-liquid mixtures can be minimized by controlling the partial pressure of the vapor, which depends in part upon the geometry of the vapor-liquid contact medium. In another aspect of this invention, the physical and chemical performance of a direct contact condenser can be predicted based on the vapor and coolant compositions, the condensation conditions. and the geometric properties of the contact medium.

  11. Method and apparatus for high-efficiency direct contact condensation

    Science.gov (United States)

    Bharathan, D.; Parent, Y.; Hassani, A.V.

    1999-07-20

    A direct contact condenser having a downward vapor flow chamber and an upward vapor flow chamber, wherein each of the vapor flow chambers includes a plurality of cooling liquid supplying pipes and a vapor-liquid contact medium disposed thereunder to facilitate contact and direct heat exchange between the vapor and cooling liquid. The contact medium includes a plurality of sheets arranged to form vertical interleaved channels or passageways for the vapor and cooling liquid streams. The upward vapor flow chamber also includes a second set of cooling liquid supplying pipes disposed beneath the vapor-liquid contact medium which operate intermittently in response to a pressure differential within the upward vapor flow chamber. The condenser further includes separate wells for collecting condensate and cooling liquid from each of the vapor flow chambers. In alternate embodiments, the condenser includes a cross-current flow chamber and an upward flow chamber, a plurality of upward flow chambers, or a single upward flow chamber. The method of use of the direct contact condenser of this invention includes passing a vapor stream sequentially through the downward and upward vapor flow chambers, where the vapor is condensed as a result of heat exchange with the cooling liquid in the contact medium. The concentration of noncondensable gases in the resulting condensate-liquid mixtures can be minimized by controlling the partial pressure of the vapor, which depends in part upon the geometry of the vapor-liquid contact medium. In another aspect of this invention, the physical and chemical performance of a direct contact condenser can be predicted based on the vapor and coolant compositions, the condensation conditions, and the geometric properties of the contact medium. 39 figs.

  12. Directions in advanced reactor technology

    International Nuclear Information System (INIS)

    Successful nuclear power plant concepts must simultaneously performance in terms of both safety and economics. To be attractive to both electric utility companies and the public, such plants must produce economical electric energy consistent with a level of safety which is acceptable to both the public and the plant owner. Programs for reactor development worldwide can be classified according to whether the reactor concept pursues improved safety or improved economic performance as the primary objective. When improved safety is the primary goal, safety enters the solution of the design problem as a constraint which restricts the set of allowed solutions. Conversely, when improved economic performance is the primary goal, it is allowed to be pursued only to an extent which is compatible with stringent safety requirements. The three major reactor coolants under consideration for future advanced reactor use are water, helium and sodium. Reactor development programs focuses upon safety and upon economics using each coolant are being pursued worldwide. These programs are discussed

  13. Modeling of Direct Contact Condensation With OpenFOAM

    OpenAIRE

    Thiele, Roman

    2010-01-01

    Within the course of the master thesis project, two thermal phase change models for direct contact conden-sation were developed with different modeling approaches, namely inter-facial heat transfer and combustionanalysis approach. After understanding the OpenFOAM framework for two phase flow solvers with phase change capabilities, a new solver, including the two developed models for phase change, was implemented under the name of interPhaseChangeCondenseTempFoam and analyzed in a series of 18...

  14. Advance Directives - Multiple Languages: MedlinePlus

    Science.gov (United States)

    ... Supplements Videos & Tools You Are Here: Home → Multiple Languages → All Health Topics → Advance Directives URL of this page: https://medlineplus.gov/languages/advancedirectives.html Other topics A-Z A B ...

  15. Development of a direct contact ice storage system

    Energy Technology Data Exchange (ETDEWEB)

    Poirier, R. [Chicago Bridge & Iron Company, Plainfield, IL (United States)

    1989-03-01

    The program described involves the design, construction, and performance testing of a Direct Freeze Thermal Energy Storage System. Task 1 (Design) has been completed; and Task 2 (construction) is in progress, with equipment procurements presently underway. Once constructed, the system will undergo extensive laboratory performance testing and analysis, followed by an assessment of the system`s cost effectiveness. This study will advance the understanding and development of the direct freeze concept, which offers inherent benefits for thermal energy storage.

  16. Preferences for Advance Directives in Korea

    OpenAIRE

    KiSun Yeo; Jung-Eun Lee; JooYoung Cheon; Won-Hee Lee; So-Sun Kim; JuHee Lee

    2011-01-01

    Background. The goal of advance directives is to help patients retain their dignity and autonomy by making their own decisions regarding end-stage medical treatment. The purpose of this study was to examine preferences of advance directives among general population in Korea. Method. A descriptive cross-sectional survey was performed from October 2007 to June 2008 in Seoul, Korea. A total of 336 city-dwelling adults self-administered the questionnaire and returned it via mail. Data analyses we...

  17. Study of the advancing and receding contact angles: liquid sorption as a cause of contact angle hysteresis.

    Science.gov (United States)

    Lam, C N C; Wu, R; Li, D; Hair, M L; Neumann, A W

    2002-02-25

    Two types of experiments were used to study the behavior of both advancing and receding contact angles, namely the dynamic one-cycle contact angle (DOCA) and the dynamic cycling contact angle (DCCA) experiments. For the preliminary study, DOCA measurements of different liquids on different solids were performed using an automated axisymmetric drop shape analysis-profile (ADSA-P). From these experimental results, four patterns of receding contact angle were observed: (1) time-dependent receding contact angle; (2) constant receding contact angle; (3) 'stick/slip'; (4) no receding contact angle. For the purpose of illustration, results from four different solid surfaces are shown. These solids are: FC-732-coated surface; poly(methyl methacrylate/n-butyl methacrylate) [P(MMA/nBMA)]; poly(lactic acid) (DL-PLA); and poly(lactic/glycolic acid) 50/50 (DL-PLGA 50/50). Since most of the surfaces in our studies exhibit time dependence in the receding contact angle, a more extended study was conducted using only FC-732-coated surfaces to better understand the possible causes of decreasing receding contact angle and contact angle hysteresis. Contact angle measurements of 21 liquids from two homologous series (i.e. n-alkanes and 1-alcohols) and octamethylcyclotetrasiloxane (OCMTS) on FC-732-coated surfaces were performed. It is apparent that the contact angle hysteresis decreases with the chain length of the liquid. It was found that the receding contact angle equals the advancing angle when the alkane molecules are infinitely large. These results strongly suggest that the chain length and size of the liquid molecule could contribute to contact angle hysteresis phenomena. Furthermore, DCCA measurements of six liquids from the two homologous series on FC-732-coated surfaces were performed. With these experimental results, one can construe that the time dependence of contact angle hysteresis on relatively smooth and homogeneous surfaces is mainly caused by liquid retention

  18. Polyazole hollow fiber membranes for direct contact membrane distillation

    KAUST Repository

    Maab, Husnul

    2013-08-07

    Porous hollow fiber membranes were fabricated from fluorinated polyoxadiazole and polytriazole by a dry-wet spinning method for application in desalination of Red Sea water by direct contact membrane distillation (DCMD). The data were compared with commercially available hollow fiber MD membranes prepared from poly(vinylidene fluoride). The membranes were characterized by electron microscopy, liquid entry pressure (LEP), and pore diameter measurements. Finally, the hollow fiber membranes were tested for DCMD. Salt selectivity as high as 99.95% and water fluxes as high as 35 and 41 L m -2 h-1 were demonstrated, respectively, for polyoxadiazole and polytriazole hollow fiber membranes, operating at 80 C feed temperature and 20 C permeate. © 2013 American Chemical Society.

  19. 21 CFR 882.1570 - Powered direct-contact temperature measurement device.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Powered direct-contact temperature measurement....1570 Powered direct-contact temperature measurement device. (a) Identification. A powered direct-contact temperature measurement device is a device which contains a power source and is used to...

  20. Boron removal from aqueous solution by direct contact membrane distillation

    International Nuclear Information System (INIS)

    The removal of boron from aqueous solution by direct contact membrane distillation (DCMD) was studied with self-prepared polyvinylidene fluoride (PVDF) hollow fiber membranes in the present work. The effect of pH, boron concentration, temperature and salt concentration of the feed solution on the boron rejection was investigated. The experimental results indicated that boron rejection was less dependent on the feed pH and salt concentration. DCMD process had high boron removal efficiency (>99.8%) and the permeate boron was below the maximum permissible level even at feed concentration as high as 750 mg/L. Although the permeate flux was enhanced exponentially with the feed temperature increasing, the influence of feed temperature on the boron rejection could be neglected. Finally, the natural groundwater sample containing 12.7 mg/L of boron was treated by DCMD process. The permeate boron kept below 20 μg/L whether the feed was acidified or not, but pre-acidification was helpful to maintain the permeate flux stability. All the experimental results indicated that DCMD could be efficiently used for boron removal from aqueous solution.

  1. Treatment of radioactive wastewater using direct contact membrane distillation

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Haiyang [Laboratory of Environmental Technology, Institute of Nuclear and New Energy Technology (INET), Tsinghua University, Beijing 100084 (China); Wang, Jianlong, E-mail: wangjl@tsinghua.edu.cn [Laboratory of Environmental Technology, Institute of Nuclear and New Energy Technology (INET), Tsinghua University, Beijing 100084 (China); Key Laboratory of Advanced Reactor Engineering and Safety, Ministry of Education, Tsinghua University, Beijing 100084 (China)

    2013-10-15

    Highlights: • DCMD process can separate almost all Cs{sup +}, Sr{sup 2+}, Co{sup 2+} from liquid wastes. • The permeate flux decreased linearly when NaNO{sub 3}concentration increased. • DGM could be used to estimate the mass transfer. • DCMD is a promising separation process for LLRW treatment. -- Abstract: Direct contact membrane distillation (DCMD) was used to treat low level radioactive wastewater (LLRW). The dusty gas model (DGM) was used to analyze the mass transfer mechanism and calculate the permeate flux. The operating parameters such as feed temperature, feed velocity and feed concentration were studied. The experimental results showed that DCMD process can separate almost all Cs{sup +}, Sr{sup 2+} and Co{sup 2+} from wastewater. The permeate flux decreased linearly when NaNO{sub 3} concentration increased from 1.0 to 200 g/L. The permeate flux remained about 60% of its initial flux even when NaNO{sub 3} concentration in feed solution was as high as 200 g/L. The dusty gas model can be successfully applied to estimate the mass transfer, and the experimental permeate flux values fitted well with that calculated by DGM. DCMD is a promising separation process for low level radioactive wastewater treatment.

  2. Treatment of radioactive wastewater using direct contact membrane distillation

    International Nuclear Information System (INIS)

    Highlights: • DCMD process can separate almost all Cs+, Sr2+, Co2+ from liquid wastes. • The permeate flux decreased linearly when NaNO3concentration increased. • DGM could be used to estimate the mass transfer. • DCMD is a promising separation process for LLRW treatment. -- Abstract: Direct contact membrane distillation (DCMD) was used to treat low level radioactive wastewater (LLRW). The dusty gas model (DGM) was used to analyze the mass transfer mechanism and calculate the permeate flux. The operating parameters such as feed temperature, feed velocity and feed concentration were studied. The experimental results showed that DCMD process can separate almost all Cs+, Sr2+ and Co2+ from wastewater. The permeate flux decreased linearly when NaNO3 concentration increased from 1.0 to 200 g/L. The permeate flux remained about 60% of its initial flux even when NaNO3 concentration in feed solution was as high as 200 g/L. The dusty gas model can be successfully applied to estimate the mass transfer, and the experimental permeate flux values fitted well with that calculated by DGM. DCMD is a promising separation process for low level radioactive wastewater treatment

  3. Advanced Automated Directional Solidification Furnace (AADSF)

    Science.gov (United States)

    1983-01-01

    The Advanced Automated Directional Solidification Furnace (AADSF) with the Experimental Apparatus Container (EAC) attached flew during the USMP-2 mission. This assembly consists of a furnace module, a muffle tube assembly and a translation mechanism which are enclosed in the EAC. During USMP-2, the AADSF was used to study the growth of mercury cadmium telluride crystals in microgravity by directional solidification, a process commonly used on earth to process metals and grow crystals. The furnace is tubular and has three independently controlled temperature zone . The sample travels from the hot zone of the furnace (1600 degrees F) where the material solidifies as it cools. The solidification region, known as the solid/liquid interface, moves from one end of the sample to the other at a controlled rate, thus the term directional solidification.

  4. Directional close-contact melting in glacier ice

    Science.gov (United States)

    Kowalski, Julia; Schüller, Kai

    2015-04-01

    The Saturnian moon Enceladus shows incidence of liquid water underneath a thick ice sheet cover and is thought to be a potential candidate for extraterrestrial life. However, direct exploration of these subglacial aquatic ecosystems is very challenging. Within the scope of the joint research project 'Enceladus Explorer' (EnEx) (consisting of FH Aachen, RWTH Aachen, Bergische Universität Wuppertal, Universität Bremen, TU Braunschweig und Bundeswehr Universität München), initiated by the German Space Agency, a maneuverable close-contact melting probe has been developed. The force-regulated and heater-controlled probe is able to melt against gravity or even on a curved trajectory. Hence, it offers additional degrees of freedom in its melting motion, e.g. for target oriented melting or obstacle avoidance strategies. General feasibility of the concept has been demonstrated in various field tests. However, in order to optimize its design and to adopt it to extraterrestrial missions a simulation model is needed, capable of determining melting velocity and efficiency at given environmental conditions and system configurations. Within this contribution, the physical situation is abstracted into a quasi-stationary mathematical model description, and a numerical solution strategy is developed to compute melting velocity and temperature distribution within the probe and the surrounding ice. We present an inverse solution approach, in which a background velocity field of the ice mimics the melting velocity. The fundamental balance laws are solved with the corresponding melting rate. Following Newton's laws, the resulting force acting on the probe has to balance the contact force exerted by the probe and can hence be used for convergence. We present both, analytical results to a simplified head geometry, as well as results from a simulation model implemented into the open source software Elmer for arbitrary head geometries. The latter can deal with the full 3d situation

  5. Polymer-Metal Schottky Contact with Direct-Current Outputs.

    Science.gov (United States)

    Shao, Hao; Fang, Jian; Wang, Hongxia; Dai, Liming; Lin, Tong

    2016-02-17

    A freestanding conducting polymer plate with one side forming a Schottky contact and the other side an Ohmic contact with two different metal electrodes can generate a DC voltage with an output current density as high as 218.6 μA cm(-2) upon mechanical deformation. PMID:26639910

  6. Whither papillon? Future directions for contact radiotherapy in rectal cancer

    DEFF Research Database (Denmark)

    Lindegaard, J; Gerard, J P; Sun Myint, A;

    2007-01-01

    Although contact radiotherapy was developed 70 years ago, and is highly effective with cure rates of over 90% for early rectal cancer, there are few centres that offer this treatment today. One reason is the lack of replacement of ageing contact X-ray machines, many of which are now over 30 years...

  7. [Euthanasia in advanced dementia: directive is useful].

    Science.gov (United States)

    Wijsbek, Henri

    2013-01-01

    The Dutch Euthanasia Act states that an advance directive can replace an actual request for euthanasia in cases in which a patient has become unable to make autonomous decisions. In Euthanasia and the Severely Demented, I agree with Keizer that the severely demented can suffer unbearably, but contrary to Keizer I do not believe that it is impossible to state in advance the conditions under which one would not wish to go on living any longer. Consequently, euthanasia can be permissible even in patients with late-stage dementia, provided that the other due-care criteria are met. Permissibility by itself, however, will not settle disputes about borderline cases. Due to the erratic course of the disease, the right moment for euthanasia may very well be impossible to determine. PMID:23777971

  8. Direct determination of three-phase contact line properties on nearly molecular scale.

    Science.gov (United States)

    Winkler, P M; McGraw, R L; Bauer, P S; Rentenberger, C; Wagner, P E

    2016-01-01

    Wetting phenomena in multi-phase systems govern the shape of the contact line which separates the different phases. For liquids in contact with solid surfaces wetting is typically described in terms of contact angle. While in macroscopic systems the contact angle can be determined experimentally, on the molecular scale contact angles are hardly accessible. Here we report the first direct experimental determination of contact angles as well as contact line curvature on a scale of the order of 1nm. For water nucleating heterogeneously on Ag nanoparticles we find contact angles around 15 degrees compared to 90 degrees for the corresponding macroscopically measured equilibrium angle. The obtained microscopic contact angles can be attributed to negative line tension in the order of -10(-10) J/m that becomes increasingly dominant with increasing curvature of the contact line. These results enable a consistent theoretical description of heterogeneous nucleation and provide firm insight to the wetting of nanosized objects. PMID:27183880

  9. Dietary biomarkers: advances, limitations and future directions

    Directory of Open Access Journals (Sweden)

    Hedrick Valisa E

    2012-12-01

    Full Text Available Abstract The subjective nature of self-reported dietary intake assessment methods presents numerous challenges to obtaining accurate dietary intake and nutritional status. This limitation can be overcome by the use of dietary biomarkers, which are able to objectively assess dietary consumption (or exposure without the bias of self-reported dietary intake errors. The need for dietary biomarkers was addressed by the Institute of Medicine, who recognized the lack of nutritional biomarkers as a knowledge gap requiring future research. The purpose of this article is to review existing literature on currently available dietary biomarkers, including novel biomarkers of specific foods and dietary components, and assess the validity, reliability and sensitivity of the markers. This review revealed several biomarkers in need of additional validation research; research is also needed to produce sensitive, specific, cost-effective and noninvasive dietary biomarkers. The emerging field of metabolomics may help to advance the development of food/nutrient biomarkers, yet advances in food metabolome databases are needed. The availability of biomarkers that estimate intake of specific foods and dietary components could greatly enhance nutritional research targeting compliance to national recommendations as well as direct associations with disease outcomes. More research is necessary to refine existing biomarkers by accounting for confounding factors, to establish new indicators of specific food intake, and to develop techniques that are cost-effective, noninvasive, rapid and accurate measures of nutritional status.

  10. Workshop on Direct Contact Heat Transfer at the Solar Energy Research Institute

    CERN Document Server

    Boehm, R

    1988-01-01

    to increase the use of direct contact processes, the National Science Foundation sup­ ported a workshop on direct contact heat transfer at the Solar Energy Research Insti­ tute in the summer of 1985. We served as organizers for this workshop, which em­ phasized an area of thermal engineering that, in our opinion, has great promise for the future, but has not yet reached the point of wide-spread commercial application. Hence, a summary of the state of knowledge at this point is timely. The workshop had a dual objective: 1. To summarize the current state of knowledge in such a form that industrial practi­ tioners can make use of the available information. 2. To indicate the research and development needed to advance the state-of-the-art, indicating not only what kind of research is needed, but also the industrial poten­ tial that could be realized if the information to be obtained through the proposed research activities were available.

  11. Atomic-Scale Engineering of Abrupt Interface for Direct Spin Contact of Ferromagnetic Semiconductor with Silicon

    Science.gov (United States)

    Averyanov, Dmitry V.; Karateeva, Christina G.; Karateev, Igor A.; Tokmachev, Andrey M.; Vasiliev, Alexander L.; Zolotarev, Sergey I.; Likhachev, Igor A.; Storchak, Vyacheslav G.

    2016-03-01

    Control and manipulation of the spin of conduction electrons in industrial semiconductors such as silicon are suggested as an operating principle for a new generation of spintronic devices. Coherent injection of spin-polarized carriers into Si is a key to this novel technology. It is contingent on our ability to engineer flawless interfaces of Si with a spin injector to prevent spin-flip scattering. The unique properties of the ferromagnetic semiconductor EuO make it a prospective spin injector into silicon. Recent advances in the epitaxial integration of EuO with Si bring the manufacturing of a direct spin contact within reach. Here we employ transmission electron microscopy to study the interface EuO/Si with atomic-scale resolution. We report techniques for interface control on a submonolayer scale through surface reconstruction. Thus we prevent formation of alien phases and imperfections detrimental to spin injection. This development opens a new avenue for semiconductor spintronics.

  12. Direct-contact condensation of low-density steam on seawater at high inlet noncondensable concentrations

    Energy Technology Data Exchange (ETDEWEB)

    Zangrando, F.; Bharathan, D. (National Renewable Energy Lab., Golden, CO (United States))

    1993-08-01

    Computer models and experimental data are summarized to characterize the condensation of low-density steam in direct contact with a process fluid that is distributed over structured packings of various geometries. The one-dimensional models integrate the heat, mass, and momentum processes in the two streams, over the height of the contactor. Both cocurrent and countercurrent flows of the two streams were analyzed. The models were validated extensively with experimental data obtained with fresh water and with seawater, at high inlet noncondensable concentrations. The data obtained in these experiments provide a broad engineering data base to design and evaluate the performance of advanced heat exchangers for a number of applications, such as production of electrical power and/or potable water using low-density steam, as could be used in Ocean Thermal Energy Conversion systems and in the low-pressure stages of conventional power cycles. 13 refs., 14 figs., 3 tabs.

  13. Toward full-chip prediction of yield-limiting contact patterning failure: correlation of simulated image parameters to advanced contact metrology metrics

    Science.gov (United States)

    Sturtevant, John L.; Chou, Dyiann

    2006-03-01

    Electrical failure due to incomplete contacts or vias has arisen as one of the primary modes of yield loss for 130 nm and below designs in manufacturing. Such failures are generally understood to arise from both random and systematic sources. The addition of redundant vias, where possible, has long been an accepted DFM practice for mitigating the impact of random defects. Incomplete vias are often characterized by having a diameter near the target dimension but a depth of less than 100% of target. As such, it is a difficult problem to diagnose and debug in-line, since bright and dark field optical inspection systems cannot typically distinguish between a closed, partially open and fully open contact. Advanced metrology systems have emerged in recent years to meet this challenge, but no perfect manufacturing solution has yet been identified for full field verification of all contacts. Voltage Contrast (VC) SEM metrology biases the wafer to directly measure electrical conductivity after fill / polish, and can therefore easily discern a lack of electrical connection to the underlying conductor caused by incomplete photo, etch, or fill processing. While an entire wafer can in principal be VC scanned, throughput limitations dictate very sparse sampling in manufacturing. SEM profile grading (PG) leverages the rich content of the secondary electron waveform to decipher information about the bottom of the contact. Several authors have demonstrated an excellent response of the Profile Grade to intentional defocus vectors. However, the SEM can only target discreet or single digit groupings of contacts, and therefore requires intelligent guidance to identify those contacts which are most prone to failure, enabling protection of the fab WIP. An a-priori knowledge of which specific contacts in a layout are most likely to fail would prove very useful for proactive inspection in manufacturing. Model based pre-manufacturing verification allows for such knowledge to be communicated

  14. State-of-the-art and needs for jet instability and direct contact condensation model improvements

    Directory of Open Access Journals (Sweden)

    Bousbia-Salah Anis

    2007-01-01

    Full Text Available There is a common understanding among thermal-hydraulic experts that the system analysis codes have currently reached an acceptable degree of maturity. Reliable application, however, is still limited to the validated domain. There is a growing need for qualified codes in assessing the safety of the existing reactors and for developing advanced reactor systems. Under conditions involving multi-phase flow simulations, the use of classical methods, mainly based upon the one dimensional approach, is not appropriate at all. The use of new computational models, such as the direct numerical simulation, large-eddy simulation or other advanced computational fluid dynamics methods, seems to be more suitable for more complex events. For this purpose, the European Commission financed NURESIM Integrated Project (as a part of the FP6 programme, was adopted to provide the initial step towards a Common European Standard Software Platform for Modeling, recording and recovering computer data for nuclear reactor simulations. Some of the studies carried out at the University of Pisa within the framework of the NURESIM project are presented in this paper. They mainly concern the investigation of two critical phenomena connected with jet instabilities and direct contact condensation that occur during emergency core cooling. Through these examples, the state-of-the-art and the need for model improvements and validation against new experimental data for the sake of getting a better understanding and more accurate predictions are discussed.

  15. Beyond competence: advance directives in dementia research.

    Science.gov (United States)

    Jongsma, Karin Rolanda; van de Vathorst, Suzanne

    2015-01-01

    Dementia is highly prevalent and incurable. The participation of dementia patients in clinical research is indispensable if we want to find an effective treatment for dementia. However, one of the primary challenges in dementia research is the patients' gradual loss of the capacity to consent. Patients with dementia are characterized by the fact that, at an earlier stage of their life, they were able to give their consent to participation in research. Therefore, the phase when patients are still competent to decide offers a valuable opportunity to authorize research, by using an advance research directive (ARD). Yet, the use of ARDs as an authorization for research participation remains controversial. In this paper we discuss the role of autonomous decision-making and the protection of incompetent research subjects. We will show why ARDs are a morally defensible basis for the inclusion of this population in biomedical research and that the use of ARDs is compatible with the protection of incompetent research subjects. PMID:26458366

  16. Sibling Relation, Ethnic Prejudice, Direct and Indirect Contact: There is a Connection?

    OpenAIRE

    Sara Alfieri; Elena Marta

    2015-01-01

    The literature on the socialisation of prejudice has concentrated on “vertical” processes (from parents to children), ignoring siblings’ contribution. This work aims to investigate the effect of contact (direct or indirect) with the outgroup that young people experience a) directly or b) indirectly through older or younger siblings’ friendships. Our hypotheses are a) that young people with friends in the outgroup will report lower prejudice levels (direct contact), as will young people who ha...

  17. Models of advance directives in mental health care: stakeholder views

    OpenAIRE

    Atkinson, J.M.; Garner, H.C.; Gilmour, W H

    2004-01-01

    Objective: The aim of this study was to examine perceptions of the place of advance directives in mental health care. Methods: Postal survey of stakeholders was carried out to assess their views on different models of advance directives in mental health care. A total of 473 responded. Results: In all, 28% of psychiatrists thought advance directives were needed compared to 89% of voluntary organisations and above two–thirds of the other stakeholder groups. There were clear tensions be...

  18. Numerical Analysis of Lead-Bismuth-Water Direct Contact Boiling Heat Transfer

    Science.gov (United States)

    Yamada, Yumi; Takahashi, Minoru

    Direct contact boiling heat transfer of sub-cooled water with lead-bismuth eutectic (Pb-Bi) was investigated for the evaluation of the performance of steam generation in direct contact of feed water with primary Pb-Bi coolant in upper plenum above the core in Pb-Bi-cooled direct contact boiling water fast reactor. An analytical two-fluid model was developed to estimate the heat transfer numerically. Numerical results were compared with experimental ones for verification of the model. The overall volumetric heat transfer coefficient was calculated from heat exchange rate in the chimney. It was confirmed that the calculated results agreed well with the experimental result.

  19. Direct therapeutic intervention for advanced pancreatic cancer

    OpenAIRE

    Takakura, Kazuki; Koido, Shigeo

    2015-01-01

    Currently, chemotherapy is an accredited, standard treatment for unresectable, advanced pancreatic cancer (PC). However, it has been still showed treatment-resistance and followed dismal prognosis in many cases. Therefore, some sort of new, additional treatments are needed for the better therapeutic results for advanced PC. According to the previous reports, it is obvious that interventional endoscopic ultrasonography (EUS) is a well-established, helpful and low-risky procedure in general. As...

  20. A method of heat accumulation and a direct-contact latent melting heat thermal accumulator

    International Nuclear Information System (INIS)

    The invention relates to a method for the accumulation of heat, and to a direct-contact latent melting-heat thermal accumulator. According to the invention, a coolant fluid F is caused to be in direct contact with a material C having a high latent melting-heat, said fluid F and material C being in heat exchange relationship at a temperature in the vicinity of the melting point of C, whereby, when hot fluid F is caused to be in direct contact with material C, the later will melt and store heat in the form of latent melting-heat while cooling fluid F, and when cold fluid F is caused to be in direct contact with material C, the latter will solidify by transferring heat to fluid F. This can be applied to the manufacturing of heat-exchangers for coupling an electric power-station to a distribution network

  1. The efficiency of direct integration methods in elastic contact-impact problems

    Institute of Scientific and Technical Information of China (English)

    Ibrahim H. Guzelbey; Ahmet Erklig; Bahattin Kanber; Keren Wang

    2005-01-01

    A comparison of direct integration methods is made and their efficiency is investigated for impact problems. Newmark, Wilson-θ, Central Difference and Houbolt Methods are used as direct integration methods. Impact analysis includes that of elastic and large deformation based upon updated Lagrangian including buckling check. The results show that the direct integration methods give different results in different contact-impact cases.

  2. Universal scaling behavior of directed percolation and the pair contact process in an external field

    OpenAIRE

    Lubeck, S.; R. D. Willmann

    2002-01-01

    We consider the scaling behavior of directed percolation and of the pair contact process with a conjugated field. In particular we determine numerically the equation of state and show that both models are characterized by the same universal scaling function. Furthermore we derive the equation of state for the pair contact process within a mean-field approach which again agrees with the mean-field equation of state of the directed percolation universality class.

  3. Universal scaling behaviour of directed percolation and the pair contact process in an external field

    International Nuclear Information System (INIS)

    We consider the scaling behaviour of directed percolation and of the pair contact process with a conjugated field. In particular we determine numerically the equation of state and show that both models are characterized by the same universal scaling function. Furthermore we derive the equation of state for the pair contact process within a mean-field approach which again agrees with the mean-field equation of state of the directed percolation universality class

  4. Parallel analog VLSI architectures for computation of heading direction and time-to-contact

    OpenAIRE

    Indiveri, Giacomo; Kramer, Jörg; Koch, Christof

    1996-01-01

    We describe two parallel analog VLSI architectures that integrate optical flow data obtained from arrays of elementary velocity sensors to estimate heading direction and time-to-contact. For heading direction computation, we performed simulations to evaluate the most important qualitative properties of the optical flow field and determine the best functional operators for the implementation of the architecture. For time-to-contact we exploited the divergence theorem to integrate data from ...

  5. Direct therapeutic intervention for advanced pancreatic cancer

    Science.gov (United States)

    Takakura, Kazuki; Koido, Shigeo

    2015-01-01

    Currently, chemotherapy is an accredited, standard treatment for unresectable, advanced pancreatic cancer (PC). However, it has been still showed treatment-resistance and followed dismal prognosis in many cases. Therefore, some sort of new, additional treatments are needed for the better therapeutic results for advanced PC. According to the previous reports, it is obvious that interventional endoscopic ultrasonography (EUS) is a well-established, helpful and low-risky procedure in general. As the additional treatments of the conventional therapy for advanced PC, many therapeutic strategies, such as immunotherapies, molecular biological therapies, physiochemical therapies, radioactive therapies, using siRNA, using autophagy have been developing in recent years. Moreover, the efficacy of the other potential therapeutic targets for PC using EUS-fine needle injection, for example, intra-tumoral chemotherapeutic agents (paclitaxel, irinotecan), several ablative energies (radiofrequency ablation and cryothermal treatment, neodymium-doped yttrium aluminum garnet laser, high-intensity focused ultrasound), etc., has already been showed in animal models. Delivering these promising treatments reliably inside tumor, interventional EUS may probably be indispensable existence for the treatment of locally advanced PC in near future. PMID:26677434

  6. Direct therapeutic intervention for advanced pancreatic cancer.

    Science.gov (United States)

    Takakura, Kazuki; Koido, Shigeo

    2015-12-10

    Currently, chemotherapy is an accredited, standard treatment for unresectable, advanced pancreatic cancer (PC). However, it has been still showed treatment-resistance and followed dismal prognosis in many cases. Therefore, some sort of new, additional treatments are needed for the better therapeutic results for advanced PC. According to the previous reports, it is obvious that interventional endoscopic ultrasonography (EUS) is a well-established, helpful and low-risky procedure in general. As the additional treatments of the conventional therapy for advanced PC, many therapeutic strategies, such as immunotherapies, molecular biological therapies, physiochemical therapies, radioactive therapies, using siRNA, using autophagy have been developing in recent years. Moreover, the efficacy of the other potential therapeutic targets for PC using EUS-fine needle injection, for example, intra-tumoral chemotherapeutic agents (paclitaxel, irinotecan), several ablative energies (radiofrequency ablation and cryothermal treatment, neodymium-doped yttrium aluminum garnet laser, high-intensity focused ultrasound), etc., has already been showed in animal models. Delivering these promising treatments reliably inside tumor, interventional EUS may probably be indispensable existence for the treatment of locally advanced PC in near future. PMID:26677434

  7. A modified captive bubble method for determining advancing and receding contact angles

    Energy Technology Data Exchange (ETDEWEB)

    Xue, Jian; Shi, Pan; Zhu, Lin [Key Laboratory of High Performance Polymer Materials and Technology (Nanjing University), Ministry of Eduction, Nanjing 210093 (China); Ding, Jianfu [Security and Disruptive Technologies, National Research Council Canada, 1200 Montreal Road, Ottawa, K1A 0R6, Ontario (Canada); Chen, Qingmin [Key Laboratory of High Performance Polymer Materials and Technology (Nanjing University), Ministry of Eduction, Nanjing 210093 (China); Wang, Qingjun, E-mail: njuwqj@nju.edu.cn [Key Laboratory of High Performance Polymer Materials and Technology (Nanjing University), Ministry of Eduction, Nanjing 210093 (China)

    2014-03-01

    Graphical abstract: - Highlights: • A modified captive bubble method for determining advancing and receding contact angle is proposed. • We have designed a pressure chamber with a pressure control system to the original experimental. • The modified method overcomes the deviation of the bubble in the traditional captive bubble method. • The modified captive bubble method allows a smaller error from the test. - Abstract: In this work, a modification to the captive bubble method was proposed to test the advancing and receding contact angle. This modification is done by adding a pressure chamber with a pressure control system to the original experimental system equipped with an optical angle mater equipped with a high speed CCD camera, a temperature control system and a computer. A series of samples with highly hydrophilic, hydrophilic, hydrophobic and superhydrophobic surfaces were prepared. The advancing and receding contact angles of these samples with highly hydrophilic, hydrophilic, and hydrophobic surfaces through the new methods was comparable to the result tested by the traditional sessile drop method. It is proved that this method overcomes the limitation of the traditional captive bubble method and the modified captive bubble method allows a smaller error from the test. However, due to the nature of the captive bubble technique, this method is also only suitable for testing the surface with advancing or receding contact angle below 130°.

  8. Sibling Relation, Ethnic Prejudice, Direct and Indirect Contact: There is a Connection?

    Science.gov (United States)

    Alfieri, Sara; Marta, Elena

    2015-11-01

    The literature on the socialisation of prejudice has concentrated on "vertical" processes (from parents to children), ignoring siblings' contribution. This work aims to investigate the effect of contact (direct or indirect) with the outgroup that young people experience a) directly or b) indirectly through older or younger siblings' friendships. Our hypotheses are a) that young people with friends in the outgroup will report lower prejudice levels (direct contact), as will young people who have older or younger siblings with friends in the outgroup (indirect contact); b) that other forms of contact such as having classmates/coworkers, neighbours, or employees are not effective in reducing either direct or indirect prejudice. 88 sibling dyads were administered the blatant and subtle prejudice questionnaire (Pettigrew & Meertens, 1995) and some ad hoc items aimed at investigating the typology of the contact experienced. The analysis of mixed ANOVA reveals that the first hypothesis was partially confirmed in that prejudice (subtle for the younger sibling and blatant for the older one) decreases in a statistically significant way only when there is the co-presence of direct and indirect contact. The second hypothesis is fully confirmed as no statistically significant differences emerged between the groups. PMID:27247684

  9. Sibling Relation, Ethnic Prejudice, Direct and Indirect Contact: There is a Connection?

    Directory of Open Access Journals (Sweden)

    Sara Alfieri

    2015-11-01

    Full Text Available The literature on the socialisation of prejudice has concentrated on “vertical” processes (from parents to children, ignoring siblings’ contribution. This work aims to investigate the effect of contact (direct or indirect with the outgroup that young people experience a directly or b indirectly through older or younger siblings’ friendships. Our hypotheses are a that young people with friends in the outgroup will report lower prejudice levels (direct contact, as will young people who have older or younger siblings with friends in the outgroup (indirect contact; b that other forms of contact such as having classmates/coworkers, neighbours, or employees are not effective in reducing either direct or indirect prejudice. 88 sibling dyads were administered the blatant and subtle prejudice questionnaire (Pettigrew & Meertens, 1995 and some ad hoc items aimed at investigating the typology of the contact experienced. The analysis of mixed ANOVA reveals that the first hypothesis was partially confirmed in that prejudice (subtle for the younger sibling and blatant for the older one decreases in a statistically significant way only when there is the co-presence of direct and indirect contact. The second hypothesis is fully confirmed as no statistically significant differences emerged between the groups.

  10. Advances in the directed evolution of proteins

    OpenAIRE

    Lane, Michael D.; Seelig, Burckhard

    2014-01-01

    Natural evolution has produced a great diversity of proteins that can be harnessed for numerous applications in biotechnology and pharmaceutical science. Commonly, specific applications require proteins to be tailored by protein engineering. Directed evolution is a type of protein engineering that yields proteins with the desired properties under well-defined conditions and in a practical time frame. While directed evolution has been employed for decades, recent creative developments enable t...

  11. [Written advance directives in dementia: useful and relevant].

    Science.gov (United States)

    Widdershoven, Guy A M; Nieuwenhuijzen Kruseman, Arie C; van Wijmen, Frans C B

    2014-01-01

    According to the Dutch euthanasia law, the current wishes of the patient can be replaced by an advance directive if the patient is unable to give consent. However, Dutch physicians say they have difficulty responding to advance directives in people with dementia. A crucial issue is how to establish whether the patient actually suffers in a specific situation. We argue that the patient's wishes, views and decisions should be discussed in a timely manner, and laid down both in patient directives and in the doctor's files. We also ask for regular discussion, updating and reaffirmation of the advance directive so that the patient can trust the doctor knowing the patient's wishes and what constitutes unbearable suffering for that patient. Through frequent discussion and reaffirmation, the advance directive can play the role intended by the law on euthanasia. PMID:25424631

  12. Integrating Advance Research Directives into the European Legal Framework.

    Science.gov (United States)

    Andorno, Roberto; Gennet, Eloïse; Jongsma, Karin; Elger, Bernice

    2016-04-01

    The possibility of using advance directives to prospectively consent to research participation in the event of dementia remains largely unexplored in Europe. Moreover, the legal status of advance directives for research is unclear in the European regulations governing biomedical research. The article explores the place that advance research directives have in the current European legal framework, and considers the possibility of integrating them more explicitly into the existing regulations. Special focus is placed on issues regarding informed consent, the role of proxies, and the level of acceptable risks and burdens. PMID:27228684

  13. Put It in Writing: Questions and Answers on Advance Directives

    Science.gov (United States)

    ... at any time. Any alterations and any written revocation should be signed and dated, and copies should ... the National Hospice and Palliative Care Organization (NHPCO) offers free, state-specific advance directives and advice for ...

  14. Evidence for transmission of bluetongue virus serotype 26 through direct contact.

    Directory of Open Access Journals (Sweden)

    Carrie Batten

    Full Text Available The aim of this study was to assess the mechanisms of transmission of bluetongue virus serotype 26 (BTV-26 in goats. A previous study, which investigated the pathogenicity and infection kinetics of BTV-26 in goats, unexpectedly revealed that one control goat may have been infected through a direct contact transmission route. To investigate the transmission mechanisms of BTV-26 in more detail an experimental infection study was carried out in which three goats were infected with BTV-26, three goats were kept uninfected, but were housed in direct contact with the infected goats, and an additional four goats were kept in indirect contact separated from infected goats by metal gates. This barrier allowed the goats to have occasional face-to-face contact in the same airspace, but feeding, watering, sampling and environmental cleaning was carried out separately. The three experimentally infected goats did not show clinical signs of BTV, however high levels of viral RNA were detected and virus was isolated from their blood. At 21 dpi viral RNA was detected in, and virus was isolated from the blood of the three direct contact goats, which also seroconverted. The four indirect barrier contact goats remained uninfected throughout the duration of the experiment. In order to assess replication in a laboratory model species of Culicoides biting midge, more than 300 Culicoides sonorensis were fed a BTV-26 spiked blood meal and incubated for 7 days. The dissemination of BTV-26 in individual C. sonorensis was inferred from the quantity of virus RNA and indicated that none of the insects processed at day 7 possessed transmissible infections. This study shows that BTV-26 is easily transmitted through direct contact transmission between goats, and the strain does not seem to replicate in C. sonorensis midges using standard incubation conditions.

  15. New directions in point-contact spectroscopy based on scanning tunneling microscopy techniques (Review Article)

    International Nuclear Information System (INIS)

    Igor Yanson showed 38 years ago for the first time a point-contact measurement where he probed the energy resolved spectroscopy of the electronic scattering inside the metal. Since this first measurement, the pointcontact spectroscopy (PCS) technique improved enormously. The application of the scanning probe microscopy (SPM) techniques in the late 1980s allowed achieving contacts with a diameter of a single atom. With the introduction of the mechanically controlled break junction technique, even spectroscopy on freely suspended chains of atoms could be performed. In this paper, we briefly review the current developments of PCS and show recent experiments in advanced scanning PCS based on SPM techniques. We describe some results obtained with both needle-anvil type of point contacts and scanning tunneling microscopy (STM). We also show our first attempt to lift up with a STM a chain of single gold atoms from a Au(110) surface.

  16. Advance directives, dementia, and withholding food and water by mouth.

    Science.gov (United States)

    Menzel, Paul T; Chandler-Cramer, M Colette

    2014-01-01

    People with dementia who are no longer competent have limited control over how their lives end. But an advance directive to withhold food and water by mouth could be used to ensure that one does not live for years in severe dementia. Such directives are arguably already legal. PMID:24821250

  17. Evaluation of antibacterial effects of pulp capping agents with direct contact test method

    OpenAIRE

    Yalcin, Muhammet; Arslan, Ugur; Dundar, Ayse

    2014-01-01

    Objectives: Calcium hydroxide has been used in dentistry as a major capping material having the capacity to introduce the formation of a mineralized dentin bridge, but it has no direct inducing effect to the pulp cells. The purpose of this study was to evaluate the antibacterial properties of three different pulp capping agents using a direct contact test (DCT). Materials and Methods: The antibacterial properties of three pulp capping agents were evaluated a DCT. For the DCT, wells (n = 12) o...

  18. Livestock-Associated MRSA Carriage in Patients without Direct Contact with Livestock

    OpenAIRE

    van Rijen, Miranda M. L.; Bosch, Thijs; Verkade, Erwin J. M.; Schouls, Leo; Kluytmans, Jan A. J. W.; ,

    2014-01-01

    Background Livestock-associated MRSA (MC398) has emerged and is related to an extensive reservoir in pigs and veal calves. Individuals with direct contact with these animals and their family members are known to have high MC398 carriage rates. Until now it was assumed that MC398 does not spread to individuals in the community without pig or veal calf exposure. To test this, we identified the proportion of MC398 in MRSA positive individuals without contact with pigs/veal calves or other known ...

  19. Direct probing of contact electrification by using optical second harmonic generation technique

    Science.gov (United States)

    Chen, Xiangyu; Taguchi, Dai; Manaka, Takaaki; Iwamoto, Mitsumasa; Wang, Zhong Lin

    2015-08-01

    Contact electrification between two different materials is one of the oldest fields of study in solid-state physics. Here, we introduced an innovative system based on optical electric-field-induced second harmonic generation (EFI-SHG) technique that can directly monitor the dynamic performance of the contact electrification on the surface of polyimide film. After the contact, the EFI-SHG system visualized briefly three relaxations of the tribo-induced charges on the surface of a polyimide film, a fast relaxation within 3 min followed by two much slower relaxations, which were possibly related to different charge diffusion routes. The contact electrification under several special experimental conditions (wind, water and steam) was studied to demonstrate the high flexibility and material selectivity of the EFI-SHG. The EFI-SHG studies confirmed the motion of the water can remove the surface charge, while the appearance and the evaporation of a thin water layer cannot enhance the charge diffusion. We anticipate that this experimental technique will find a variety of applications in the field of contact electrification and the development of the recently invented triboelectric nano generator.

  20. Interspecific Contact and Competition May Affect the Strength and Direction of Disease-Diversity Relationships for Directly Transmitted Microparasites.

    Science.gov (United States)

    O'Regan, Suzanne M; Vinson, John E; Park, Andrew W

    2015-10-01

    The frequency of opportunities for transmission is key to the severity of directly transmitted disease outbreaks in multihost communities. Transmission opportunities for generalist microparasites often arise from competitive and trophic interactions. Additionally, contact heterogeneities within and between species either hinder or promote transmission. General theory incorporating competition and contact heterogeneities for disease-diversity relationships is underdeveloped. Here, we present a formal framework to explore disease-diversity relationships for directly transmitted parasites that infect multiple host species, including influenza viruses, rabies virus, distemper viruses, and hantaviruses. We explicitly include host regulation via intra- and interspecific competition, where the latter can be dependent on or independent of interspecific contact rates (covering resource utilization overlap, habitat selection preferences, and temporal niche partitioning). We examine how these factors interact with frequency- and density-dependent transmission along with traits of the hosts in the assemblage, culminating in the derivation of a relationship describing the propensity for parasite fitness to decrease in species assemblages relative to that in single-host species. This relationship reveals that increases in biodiversity do not necessarily suppress frequency-dependent parasite transmission and that regulation of hosts via interspecific competition does not always lead to a reduction in parasite fitness. Our approach explicitly shows that species identity and ecological interactions between hosts together determine microparasite transmission outcomes in multispecies communities. PMID:26655572

  1. Solar Upgrade of Methane Using Dry Reforming In Direct Contact Bubble Reactor

    OpenAIRE

    Al-Ali, Khalid; Kodama, Satoshi; Kaneko, Hiroshi; Sekiguchi, Hidetoshi; Tamaura, Yutaka; Chiesa, Matteo

    2012-01-01

    The reforming behavior of a direct contact bubbling CH4-CO2 mixture, was quantitatively investigated, in an alkali carbonate based molten salt system containing suspended Ni-Al2O3 catalyst. A thermodynamical process of a solar reformer of dry methane reforming was proposed to operate in a temperature range of 600-800oC. The selectivity of the thermal fluid have been validated according to specific requirements including lower melting point, thermal and chemical stability, acting simultaneousl...

  2. Livestock-associated MRSA carriage in patients without direct contact with livestock.

    Directory of Open Access Journals (Sweden)

    Miranda M L van Rijen

    Full Text Available BACKGROUND: Livestock-associated MRSA (MC398 has emerged and is related to an extensive reservoir in pigs and veal calves. Individuals with direct contact with these animals and their family members are known to have high MC398 carriage rates. Until now it was assumed that MC398 does not spread to individuals in the community without pig or veal calf exposure. To test this, we identified the proportion of MC398 in MRSA positive individuals without contact with pigs/veal calves or other known risk factors (MRSA of unknown origin; MUO. METHODS: In 17 participating hospitals, we determined during two years the occurrence of MC398 in individuals without direct contact with livestock and no other known risk factor (n = 271 and tested in a post analysis the hypothesis whether hospitals in pig-dense areas have higher proportions of MC398 of all MUO. RESULTS: Fifty-six individuals (20.7% without animal contact carried MC398. In hospitals with high pig-densities in the adherence area, the proportion of MC398 of all MUO was higher than this proportion in hospitals without pigs in the surroundings. CONCLUSIONS: One fifth of the individuals carrying MUO carried MC398. So, MC398 is found in individuals without contact to pigs or veal calves. The way of transmission from the animal reservoir to these individuals is unclear, probably by human-to-human transmission or by exposure to the surroundings of the stables. Further research is needed to investigate the way of transmission.

  3. Advance Directive from the Romanian Social Cultural Perspective

    Directory of Open Access Journals (Sweden)

    Silvia DUMITRAS

    2013-03-01

    Full Text Available Giving value to the wishes of the terminal patients regarding the treatment at the end of their life, the use of the advance directive, as an extension of their autonomy when the patients are incompetent, represents a mean to respect and promote their dignity. The authors present and discuss the results of their research that analysed the attitude of Romanians toward the use of the advance directive to identify the usefulness of implementing such a document in the Romanian social cultural context.The target group in this research is general population over 18 years old, speaking Romanian and without psychological illnesses. The representative random sample lot included 828 persons from Iasi County. The data were recorded based on a transversal descriptive study, using the method of questionnaire enquiryThe persons participating in the study admitted the importance of respecting the patient’s dignity and autonomy with reference to decisions concerning the treatment at the end of life. For the subjects agreeing with legalizing the advance directive, the main advantages of such a document are firstly the respect of the patient’s right to decide and secondly the improvement of the medical treatment.The study showed that young, healthy and better educated individuals are interested in the advance directive and are in favour of introducing it in the current medical practice. The results of our research suggest that educational and informative programmes are needed in Romania regarding the role and usefulness of the advance directive, as well as the way to implement it, in order to encourage the implication of all adult persons in planning their own medical treatment in general and in particular in the medical decisions concerning the end of life.

  4. Development of separation techniques for a direct contact thermal energy storage system

    Energy Technology Data Exchange (ETDEWEB)

    Min, T.C. [North Carolina A& T State Univ., Greensboro, NC (United States); Tomlinson, J.J. [Oak Ridge National Lab., TN (United States)

    1989-03-01

    In direct contact ice-making processes, the refrigerant will pick up water vapor through direct percolation and oil from the compressor. The purpose of this project is to investigate methods for separating water vapor and oil from a mixture to complete a refrigeration cycle. In this paper, we report critical review on two separation techniques. From a literature search, we have identified a third technique; and plan to evaluate this method by bench-scale experiments. A recommendation for future work is included.

  5. An approach to directional drilling simulation: finite element and finite segment methods with contact

    Science.gov (United States)

    Arbatani, Siamak; Callejo, Alfonso; Kövecses, József; Kalantari, Masoud; Marchand, Nick R.; Dargahi, Javad

    2016-06-01

    Directional drilling is a popular technique for oil well drilling. Accurate prediction of the directional performance is critical in order to achieve the desired well profile. Simplified geometry methods are, to date, the industry standard for predicting directional performance. A comprehensive, high-fidelity method for the simulation of directional drilling is presented here. It consists of a detailed discretization of the actual geometry and a rigorous application of two modeling techniques: the finite element and the finite segment methods. By doing so, the dynamic problem is addressed from two different yet complementary perspectives: structural mechanics and rigid-body motion. Collision detection and contact dynamics algorithms are also presented. Results show that both methods agree in terms of the dynamic response, and that the build rate estimations are consistent with available experimental data. Owing to the framework efficiency and physics-based nature, the presented tools are very well-suited for design engineering and real-time simulation.

  6. An approach to directional drilling simulation: finite element and finite segment methods with contact

    Science.gov (United States)

    Arbatani, Siamak; Callejo, Alfonso; Kövecses, József; Kalantari, Masoud; Marchand, Nick R.; Dargahi, Javad

    2016-03-01

    Directional drilling is a popular technique for oil well drilling. Accurate prediction of the directional performance is critical in order to achieve the desired well profile. Simplified geometry methods are, to date, the industry standard for predicting directional performance. A comprehensive, high-fidelity method for the simulation of directional drilling is presented here. It consists of a detailed discretization of the actual geometry and a rigorous application of two modeling techniques: the finite element and the finite segment methods. By doing so, the dynamic problem is addressed from two different yet complementary perspectives: structural mechanics and rigid-body motion. Collision detection and contact dynamics algorithms are also presented. Results show that both methods agree in terms of the dynamic response, and that the build rate estimations are consistent with available experimental data. Owing to the framework efficiency and physics-based nature, the presented tools are very well-suited for design engineering and real-time simulation.

  7. Fluid dynamics of jet-forming elements of contact devices with directional gas stream injection

    International Nuclear Information System (INIS)

    One way to intensify heat and mass transfer processes in column-type equipment is through use of contact devices with directional gas phase injection into a liquid. Making the perforations at an angle to the tray plane permits a rise in the permissible gas velocity in the column, since inertial force adds to gravity during separation. Different arrangements of the jet-forming elements relative to one another and to partitions and baffle-type contacts installed on the trays can improve phase contact conditions and intensify heat and mass transfer. Design of jet-type trays for a specific purpose requires that the influence of jet-forming, element design parameters on at least the fluid dynamic situation on the tray be known. In this work, the authors evaluate the influence of tab bend-up angle on jet tray working characteristics. These investigations demonstrate that the jet inclination angle (the angle of maximum gas velocity in the jet) exceeds the tab bend-up angle for all types of notches over the range of angles studied. The data presented here can be used in designing various types of trays utilizing cutout-type contact elements, to optimize the arrangement of notches relative to one another and to sectioning partitions and baffles, as well as to provide control of liquid stream structure. 9 refs., 3 figs

  8. Direct TFIIA-TFIID protein contacts drive budding yeast ribosomal protein gene transcription.

    Science.gov (United States)

    Layer, Justin H; Weil, P Anthony

    2013-08-01

    We have previously shown that yeast TFIID provides coactivator function on the promoters of ribosomal protein-encoding genes (RPGs) by making direct contact with the transactivator repressor activator protein 1 (Rap1). Further, our structural studies of assemblies generated with purified Rap1, TFIID, and TFIIA on RPG enhancer-promoter DNA indicate that Rap1-TFIID interaction induces dramatic conformational rearrangements of enhancer-promoter DNA and TFIID-bound TFIIA. These data indicate a previously unknown yet critical role for yeast TFIIA in the integration of activator-TFIID contacts with promoter conformation and downstream preinitiation complex formation and/or function. Here we describe the use of systematic mutagenesis to define how specific TFIIA contacts contribute to these processes. We have verified that TFIIA is required for RPG transcription in vivo and in vitro, consistent with the existence of a critical Rap1-TFIIA-TFIID interaction network. We also identified essential points of contact for TFIIA and Rap1 within the Rap1 binding domain of the Taf4 subunit of TFIID. These data suggest a mechanism for how interactions between TFIID, TFIIA, and Rap1 contribute to the high rate of transcription initiation seen on RPGs in vivo. PMID:23814059

  9. Direct-contact condensers for open-cycle OTEC applications: Model validation with fresh water experiments for structured packings

    Science.gov (United States)

    Bharathan, D.; Parsons, B. K.; Althof, J. A.

    1988-10-01

    The objective of the reported work was to develop analytical methods for evaluating the design and performance of advanced high-performance heat exchangers for use in open-cycle thermal energy conversion (OC-OTEC) systems. This report describes the progress made on validating a one-dimensional, steady-state analytical computer of fresh water experiments. The condenser model represents the state of the art in direct-contact heat exchange for condensation for OC-OTEC applications. This is expected to provide a basis for optimizing OC-OTEC plant configurations. Using the model, we examined two condenser geometries, a cocurrent and a countercurrent configuration. This report provides detailed validation results for important condenser parameters for cocurrent and countercurrent flows. Based on the comparisons and uncertainty overlap between the experimental data and predictions, the model is shown to predict critical condenser performance parameters with an uncertainty acceptable for general engineering design and performance evaluations.

  10. Direct-contact condensers for open-cycle OTEC applications: Model validation with fresh water experiments for structured packings

    Energy Technology Data Exchange (ETDEWEB)

    Bharathan, D.; Parsons, B.K.; Althof, J.A.

    1988-10-01

    The objective of the reported work was to develop analytical methods for evaluating the design and performance of advanced high-performance heat exchangers for use in open-cycle thermal energy conversion (OC-OTEC) systems. This report describes the progress made on validating a one-dimensional, steady-state analytical computer of fresh water experiments. The condenser model represents the state of the art in direct-contact heat exchange for condensation for OC-OTEC applications. This is expected to provide a basis for optimizing OC-OTEC plant configurations. Using the model, we examined two condenser geometries, a cocurrent and a countercurrent configuration. This report provides detailed validation results for important condenser parameters for cocurrent and countercurrent flows. Based on the comparisons and uncertainty overlap between the experimental data and predictions, the model is shown to predict critical condenser performance parameters with an uncertainty acceptable for general engineering design and performance evaluations. 33 refs., 69 figs., 38 tabs.

  11. Assessing fresh and weathered petroleum hydrocarbon (PHC) fraction 2 direct soil contact values for ecological receptors

    International Nuclear Information System (INIS)

    This study evaluated the toxicity of weathered petroleum hydrocarbon (PHC) Fraction 2 (>nC10 to C16) in soil and determined direct soil contact values for ecological receptors. Ecological Tier 1 Canada-wide standards (CWS) for PHC Fraction 2 (F2) in soil are derived using ecotoxicological assessment endpoints (EC/LC/IC25s) with freshly spiked fine-textured soils. However, when applied to field samples with weathered hydrocarbons, these soil standards may be overly conservative. In this study, fine-textured soils were spiked with distilled F2 and weathered for 6 months. Toxicity tests using plants and invertebrates were then conducted. Endpoint EC/IC25s were calculated and used to formulate soil standards for weathered F2 in fine-grained soil protective of ecological receptors exposed by direct soil contact. The values for weathered F2 were found to be less restrictive than current ecological Tier 1 CWS for F2 in soil, but values for fresh and weathered F2-spiked soils were similar when current CWS were adjusted using a non-linear, more accurately predictive regression. It was concluded that the soil contact values for fresh F2 in fine-textured soil would be approximately two times higher if current ecological Tier 1 CWS were adjusted.

  12. Acceptability of an Advance Directive That Limits Food and Liquids in Advanced Dementia.

    Science.gov (United States)

    Volicer, Ladislav; Stets, Karen

    2016-02-01

    Some individuals fear living with advanced dementia and may even commit suicide if they receive dementia diagnosis. Living with advanced dementia could be prevented if a person who cannot feed himself or herself would not be fed by others. The purpose of the study was to find out how acceptable would be an advance directive that includes discontinuation of feeding at certain stage of dementia for relatives of persons who died with dementia. All participants of 2 focus groups would be willing to indicate at least 1 condition in which they would not want to be fed. Some of them would be willing to make a proxy decision to stop feeding in the absence of advance directives. PMID:25313239

  13. Spatial interference between gaze direction and gaze location: a study on the eye contact effect.

    Science.gov (United States)

    Cañadas, Elena; Lupiáñez, Juan

    2012-01-01

    Perceived gaze in faces is an important social cue that influences spatial orienting of attention. In three experiments, we examined whether the social relevance of gaze direction modulated spatial interference in response selection, using three different stimuli: faces, isolated eyes, and symbolic eyes (Experiments 1, 2, and 3, respectively). Each experiment employed a variant of the spatial Stroop paradigm in which face location and gaze direction were put into conflict. Results showed a reverse congruency effect between face location to the right or left of fixation and gaze direction only for stimuli with a social meaning to participants (Experiments 1 and 2). The opposite was observed for the nonsocial stimuli used in Experiment 3. Results are explained as facilitation in response to eye contact. PMID:22530703

  14. Direct mineral identification with Geoscan Mk II Advanced Multispectral Scanner

    Science.gov (United States)

    Lyon, Ronald J. P.; Honey, Frank R.

    1990-09-01

    Analysis of the Geoscan Mk II scanner imagery obtained over the past twelve months in Australia and in the USA has shown that this advanced system can effect direct mineral identification (DM1) with only a minimum of processing and in an operational commercial mode of use. This paper attempts to show some of these results with imagery flown over goldmineralizaon (Leonora W. Australia) porphyry-copper mineralization and associated higher-level advanced argiffic alteration (Yerington NV--Ann Mason and Buckskin Ra. ) and a copper-gold skarn nearby (Ludwig NV). In all cases simple banddifferencing is all the processing that is required and this can be effected minutes after landing from a flight using a proprietary image-display system (GIPSy) which accepts the optical disks directly. [3 1.

  15. Technological advances in site-directed spin labeling of proteins

    OpenAIRE

    Hubbell, Wayne L.; López, Carlos J.; Altenbach, Christian; Yang, Zhongyu

    2013-01-01

    Molecular flexibility over a wide time range is of central importance to the function of many proteins, both soluble and membrane. Revealing the modes of flexibility, their amplitudes, and time scales under physiological conditions is the challenge for spectroscopic methods, one of which is site-directed spin labeling EPR (SDSL-EPR). Here we provide an overview of some recent technological advances in SDSL-EPR related to investigation of structure, structural heterogeneity, and dynamics of pr...

  16. Participant observation of time allocation, direct patient contact and simultaneous activities in hospital physicians

    Directory of Open Access Journals (Sweden)

    Zupanc Andrea

    2009-06-01

    Full Text Available Abstract Background Hospital physicians' time is a critical resource in medical care. Two aspects are of interest. First, the time spent in direct patient contact – a key principle of effective medical care. Second, simultaneous task performance ('multitasking' which may contribute to medical error, impaired safety behaviour, and stress. There is a call for instruments to assess these aspects. A preliminary study to gain insight into activity patterns, time allocation and simultaneous activities of hospital physicians was carried out. Therefore an observation instrument for time-motion-studies in hospital settings was developed and tested. Methods 35 participant observations of internists and surgeons of a German municipal 300-bed hospital were conducted. Complete day shifts of hospital physicians on wards, emergency ward, intensive care unit, and operating room were continuously observed. Assessed variables of interest were time allocation, share of direct patient contact, and simultaneous activities. Inter-rater agreement of Kappa = .71 points to good reliability of the instrument. Results Hospital physicians spent 25.5% of their time at work in direct contact with patients. Most time was allocated to documentation and conversation with colleagues and nursing staff. Physicians performed parallel simultaneous activities for 17–20% of their work time. Communication with patients, documentation, and conversation with colleagues and nursing staff were the most frequently observed simultaneous activities. Applying logit-linear analyses, specific primary activities increase the probability of particular simultaneous activities. Conclusion Patient-related working time in hospitals is limited. The potential detrimental effects of frequently observed simultaneous activities on performance outcomes need further consideration.

  17. Modeling a Direct Contact Heat Exchanger used in a supercritical water loop

    International Nuclear Information System (INIS)

    In the last thirty years, Direct Contact Heat Exchangers (DCHX) have found a great success in different power engineering applications. In fact, due to the direct contact of hot and cold working fluids, it is possible to reach very high mass and energy transfer efficiencies. Despite their high performance, it is still difficult to predict the correct heat transfer as a function of plant operating conditions. Thus, this paper concerns the study of a DCHX used in a supercritical water test facility. It consists of a vessel where superheated steam is cooled by mixing it with sub-cooled water via a nozzle that sprays the fluid under the form of tiny droplets. A thermodynamic model which includes the statistical distribution of droplets and their temperature evolution is presented. To this aim, a Cumulative Distribution Function (CDF) based on Rosin–Rammler's equation is used. To evaluate both convection and evaporation energy transfer, the evolution of the velocity of the droplet as function their size is studied. A comparison of model's predictions with experimental data, for steam pressures of 1.6 and 2.1 MPa, shows reasonable good agreement. At higher pressures the model over predicts the experimental trends. - Highlights: • Modelling the thermodynamic behavior of a Direct Contact Heat Exchanger. • Steam cooled by liquid droplets coming from a spray. • Predictions are reasonable for steam pressures lower than 2.1 MPa. • The effect of the droplet distribution functions is studied. • A new correlation that fits the data at higher pressures is proposed

  18. Feedback control for distributed heat transfer mechanisms in direct-contact membrane distillation system

    KAUST Repository

    Eleiwi, Fadi

    2015-09-21

    In this paper, the problem of stabilization and production rate reference tracking for a Direct-Contact Membrane Distillation (DCMD) system is addressed. Sufficient conditions for the asymptotic and exponential stabilization for DCMD system are presented using the Gronwall-Bellman lemma and Linear Matrix Inequalities (LMIs) approaches, respectively. A nonlinear observer is then proposed to estimate the temperature distribution among the DCMD domain. This contributes to propose a reference production rate control design for the DCMD process via observer-based output control approach. Finally, numerical simulations are given to show the effectiveness of the proposed methods.

  19. Electrical Thermal Network for Direct Contact Membrane Distillation Modeling and Analysis

    KAUST Repository

    Karam, Ayman M.

    2015-02-04

    Membrane distillation is an emerging water distillation technology that offers several advantages compared to conventional water desalination processes. Although progress has been made to model and understand the physics of the process, many studies are based on steady-state assumptions or are computationally not appropriate for real time control. This paper presents the derivation of a novel dynamical model, based on analogy between electrical and thermal systems, for direct contact membrane distillation (DCMD). The proposed model captures the dynamics of temperature distribution and distilled water flux. To demonstrate the adequacy of the proposed model, validation with transient and steady-state experimental data is presented.

  20. Crossover from directed percolation to mean field behavior in the diffusive contact process

    International Nuclear Information System (INIS)

    Recently Dantas, Oliveira and Stilck (2007 J. Stat. Mech. P08009) studied how the one-dimensional diffusive contact process crosses over from the critical behavior of directed percolation to an effective mean field behavior when the diffusion rate is sent to infinity. They showed that this crossover can be described in terms of a crossover exponent φ, finding the boundaries 3≤φ≤4 in one spatial dimension. In the present work we refine and extend this result up to four spatial dimensions by means of a field-theoretic calculation and extensive numerical simulations

  1. Directed compact percolation near a damp wall: mean length and mean number of wall contacts

    International Nuclear Information System (INIS)

    Key aspects of the cluster distribution in the case of directed, compact percolation near a damp wall are derived as functions of the bulk occupation probability p and the wall occupation probability pw. The mean length of finite clusters and mean number of contacts with the wall are derived exactly, and we find that both results involve elliptic integrals and further multiple sum functions of two variables. Despite the added complication of these multiple sum functions, our analysis shows that the critical behaviour is similar to the dry wall case where these functions do not appear. We derive the critical amplitudes as a function of pw. (paper)

  2. Evaluation of a direct contact heat exchanger; Evaluacion de un intercambiador de calor de contacto directo

    Energy Technology Data Exchange (ETDEWEB)

    Siqueiros, J.; Bonilla, O. [Instituto de Investigaciones Electricas, Cuernavaca (Mexico)

    1997-12-31

    In this paper the application areas of the direct contact heat exchangers is discussed, as well as its main characteristics. A description is made of the experimental equipment designed and built at pilot scale including the instrumentation employed. The methodology employed as well as the analysis and the discussion of the results are also presented. [Espanol] Se mencionan las areas de aplicacion de los intercambiadores de calor de contacto directo, asi como sus caracteristicas principales. Se describe el equipo experimental a nivel piloto disenado y construido incluyendo la instrumentacion utilizada. Se presenta la metodologia empleada asi como el analisis y discusion de los resultados.

  3. Apparent dynamic contact angle of an advancing gas--liquid meniscus

    International Nuclear Information System (INIS)

    The steady motion of an advancing meniscus in a gas-filled capillary tube involves a delicate balance of capillary, viscous, and intermolecular forces. The limit of small capillary numbers Ca (dimensionless speeds) is analyzed here with a matched asymptotic analysis that links the outer capillary region to the precursor film in front of the meniscus through a lubricating film. The meniscus shape in the outer region is constructed and the apparent dynamic contact angle Θ that the meniscus forms with the solid surface is derived as a function of the capillary number, the capillary radius, and the Hamaker's constant for intermolecular forces, under conditions of weak gas--solid interaction, which lead to fast spreading of the precursor film and weak intermolecular forces relative to viscous forces within the lubricating film. The dependence on intermolecular forces is very weak and the contact angle expression has a tight upper bound tan Θ=7.48 Ca1/3 for thick films, which is independent of the Hamaker constant. This upper bound is in very good agreement with existing experimental data for wetting fluids in any capillary and for partially wetting fluids in a prewetted capillary. Significant correction to the Ca1/3 dependence occurs only at very low Ca, where the intermolecular forces become more important and tan Θ diverges slightly from the above asymptotic behavior toward lower values

  4. Direct evaluation of contact injection efficiency into small molecule based transport layers: Influence of extrinsic factors

    Science.gov (United States)

    Abkowitz, M.; Facci, J. S.; Rehm, J.

    1998-03-01

    Studies of interface formation on conventional semiconductor materials are typically carried out under relatively pristine conditions. However, for devices based on the use of electronic polymers there is also compelling interest in exploring the variations in contact behavior that might result under realistic manufacturing conditions like multilayer device assembly based on solution coating technology. Small molecule doped polymers (MDPs) developed principally as large area coatings for electrophotographic use are now finding wider device applications. These polymers are insulators capable of transporting excess injected charge with a unipolar drift mobility which can be tuned over a wide range by varying the concentration of transport active species. Most significant in the present context, MDPs can be rendered trap free by molecular design. These unique characteristics of MDPs make it possible to analyze the relative injection efficiencies of their interfaces with various contacts simply by a direct comparison of current-voltage characteristics with time of flight drift mobility measurements carried out on the same film coatings. In this way, and apart from their intrinsic interest and practical value, MDPs and closely related polymeric media provide the ideal venue for the study of contact phenomena on molecular solids. Almost all the present measurements were carried out by measuring dark hole injection from various preformed metal substrates into the MDP film TPD/polycarbonate. Under these circumstances it was found that while injection efficiency nominally scaled with the estimated interfacial energy step there was significant variance that in some cases could be clearly associated with the specific details of interfacial chemistry. For one exceptional case where Au was evaporated on the free surface of an already cast film a time and temperature dependent contact forming process could be delineated in which the interface systematically evolved from emission

  5. Canadian advanced life support capacities and future directions

    Science.gov (United States)

    Bamsey, M.; Graham, T.; Stasiak, M.; Berinstain, A.; Scott, A.; Vuk, T. Rondeau; Dixon, M.

    2009-07-01

    Canada began research on space-relevant biological life support systems in the early 1990s. Since that time Canadian capabilities have grown tremendously, placing Canada among the emerging leaders in biological life support systems. The rapid growth of Canadian expertise has been the result of several factors including a large and technically sophisticated greenhouse sector which successfully operates under challenging climatic conditions, well planned technology transfer strategies between the academic and industrial sectors, and a strong emphasis on international research collaborations. Recent activities such as Canada's contribution of the Higher Plant Compartment of the European Space Agency's MELiSSA Pilot Plant and the remote operation of the Arthur Clarke Mars Greenhouse in the Canadian High Arctic continue to demonstrate Canadian capabilities with direct applicability to advanced life support systems. There is also a significant latent potential within Canadian institutions and organizations with respect to directly applicable advanced life support technologies. These directly applicable research interests include such areas as horticultural management strategies (for candidate crops), growth media, food processing, water management, atmosphere management, energy management, waste management, imaging, environment sensors, thermal control, lighting systems, robotics, command and data handling, communications systems, structures, in-situ resource utilization, space analogues and mission operations. With this background and in collaboration with the Canadian aerospace industry sector, a roadmap for future life support contributions is presented here. This roadmap targets an objective of at least 50% food closure by 2050 (providing greater closure in oxygen, water recycling and carbon dioxide uptake). The Canadian advanced life support community has chosen to focus on lunar surface infrastructure and not low Earth orbit or transit systems (i.e. microgravity

  6. Directions for advanced use of nuclear power in century XXI

    Energy Technology Data Exchange (ETDEWEB)

    Walter, C E

    1999-05-01

    Nuclear power can provide a significant contribution to electricity generation and meet other needs of the world and the US during the next century provided that certain directions are taken to achieve its public acceptance. These directions include formulation of projections of population, energy consumption, and energy resources over a responsible period of time. These projections will allow assessment of cumulative effects on the environment and on fixed resources. Use of fossil energy resources in a century of growing demand for energy must be considered in the context of long-term environmental damage and resource depletion. Although some question the validity of these consequences, they can be mitigated by use of advanced fast reactor technology. It must be demonstrated that nuclear power technology is safe, resistant to material diversion for weapon use, and economical. An unbiased examination of all the issues related to energy use, especially of electricity, is an essential direction to take.

  7. Analysis and hazard evaluation of heat-transfer fluids for the direct contact cooling system

    International Nuclear Information System (INIS)

    This paper discusses several low-temperature heat-transfer fluids, including water-based inorganic salt, organic salt, alcohol/glycol mixtures, silicones, and halogenated hydrocarbons in order to choose the best heat-transfer fluid for the newly designed direct contact refrigeration system. So, it contains a survey on commercial products such as propylene glycol and potassium formate as newly used in super market and food processing refrigeration. The stability of commercial fluids at the working temperature of -20 .deg. C was monitored as a function of time up to two months. And organic and inorganic compositions of candidate fluids were obtained by analytical instruments such as ES, XRF, AAS, ICP-AES, GC, and GC-MS. Analysis results indicate that commercial propylene glycol is very efficient and safe heat transfer fluids for the direct cooling system with liquid phase

  8. Advanced video extensometer for non-contact, real-time, high-accuracy strain measurement.

    Science.gov (United States)

    Pan, Bing; Tian, Long

    2016-08-22

    We developed an advanced video extensometer for non-contact, real-time, high-accuracy strain measurement in material testing. In the established video extensometer, a "near perfect and ultra-stable" imaging system, combining the idea of active imaging with a high-quality bilateral telecentric lens, is constructed to acquire high-fidelity video images of the test sample surface, which is invariant to ambient lighting changes and small out-of-plane motions occurred between the object surface and image plane. In addition, an efficient and accurate inverse compositional Gauss-Newton algorithm incorporating a temporal initial guess transfer scheme and a high-accuracy interpolation method is employed to achieve real-time, high-accuracy displacement tracking with negligible bias error. Tensile tests of an aluminum sample and a carbon fiber filament sample were performed to demonstrate the efficiency, repeatability and accuracy of the developed advanced video extensometer. The results indicate that longitudinal and transversal strains can be estimated and plotted at a rate of 117 fps and with a maximum strain error less than 30 microstrains. PMID:27557188

  9. Development and testing of new biologically-based polymers as advanced biocompatible contact lenses

    Energy Technology Data Exchange (ETDEWEB)

    Bertozzi, Carolyn R.

    2000-06-01

    Nature has evolved complex and elegant materials well suited to fulfill a myriad of functions. Lubricants, structural scaffolds and protective sheaths can all be found in nature, and these provide a rich source of inspiration for the rational design of materials for biomedical applications. Many biological materials are based in some fashion on hydrogels, the crosslinked polymers that absorb and hold water. Biological hydrogels contribute to processes as diverse as mineral nucleation during bone growth and protection and hydration of the cell surface. The carbohydrate layer that coats all living cells, often referred to as the glycocalyx, has hydrogel-like properties that keep cell surfaces well hydrated, segregated from neighboring cells, and resistant to non-specific protein deposition. With the molecular details of cell surface carbohydrates now in hand, adaptation of these structural motifs to synthetic materials is an appealing strategy for improving biocompatibility. The goal of this collaborative project between Prof. Bertozzi's research group, the Center for Advanced Materials at Lawrence Berkeley National Laboratory and Sunsoft Corporation was the design, synthesis and characterization of novel hydrogel polymers for improved soft contact lens materials. Our efforts were motivated by the urgent need for improved materials that allow extended wear, and essential feature for those whose occupation requires the use of contact lenses rather than traditional spectacles. Our strategy was to transplant the chemical features of cell surface molecules into contact lens materials so that they more closely resemble the tissue in which they reside. Specifically, we integrated carbohydrate molecules similar to those found on cell surfaces, and sulfoxide materials inspired by the properties of the carbohydrates, into hydrogels composed of biocompatible and manufacturable substrates. The new materials were characterized with respect to surface and bulk hydrophilicity

  10. Heat transfer modelling of two-phase bubbles swarm condensing in three - phase direct - contact condenser

    Directory of Open Access Journals (Sweden)

    Mahood Hameed B.

    2016-01-01

    Full Text Available An analytical model for the convective heat transfer coefficient and the two-phase bubble size of a three-phase direct contact heat exchanger was developed. Until the present, there has only been a theoretical model available that deals with a single two-phase bubble and a bubble train condensation in an immiscible liquid. However, to understand the actual heat transfer process within the three-phase direct contact condenser, characteristic models are required. A quasi - steady energy equation in a spherical coordinate system with a potential flow assumption and a cell model configuration has been simplified and solved analytically. The convective heat transfer in terms of Nu number has been derived, and it was found to be a function to Pe number and a system void fraction. In addition, the two-phase bubble size relates to the system void fraction and has been developed by solving a simple energy balance equation and using the derived convective heat transfer coefficient expression. Furthermore, the model correlates well with previous experimental data and theoretical results.

  11. Advanced materials for alternative fuel capable directly fired heat engines

    Energy Technology Data Exchange (ETDEWEB)

    Fairbanks, J.W.; Stringer, J. (eds.)

    1979-12-01

    The first conference on advanced materials for alternative fuel capable directly fired heat engines was held at the Maine Maritime Academy, Castine, Maine. It was sponsored by the US Department of Energy, (Assistant Secretary for Fossil Energy) and the Electric Power Research Institute, (Division of Fossil Fuel and Advanced Systems). Forty-four papers from the proceedings have been entered into EDB and ERA and one also into EAPA; three had been entered previously from other sources. The papers are concerned with US DOE research programs in this area, coal gasification, coal liquefaction, gas turbines, fluidized-bed combustion and the materials used in these processes or equipments. The materials papers involve alloys, ceramics, coatings, cladding, etc., and the fabrication and materials listing of such materials and studies involving corrosion, erosion, deposition, etc. (LTN)

  12. Antibiofouling Polyvinylidene Fluoride Membrane Modified by Quaternary Ammonium Compound: Direct Contact-Killing versus Induced Indirect Contact-Killing.

    Science.gov (United States)

    Zhang, Xingran; Ma, Jinxing; Tang, Chuyang Y; Wang, Zhiwei; Ng, How Yong; Wu, Zhichao

    2016-05-17

    Widespread applications of membrane technology call for the development of antibiofouling membranes. For the traditional contact-killing strategy, the antibacterial action is restricted to the surface: the membrane loses its antibiofouling efficacy once its surface is completely covered with a fouling layer. However, in this study, polyvinylidene fluoride (PVDF) microfiltration membranes blended with quaternary ammonium compound (QAC) exhibited a surprisingly lasting antimicrobial activity in the vicinity of the membrane surface. The results indicated that QAC was capable of driving surface segregation with a high structural stability, and the QAC modified membrane shows clear antibacterial effects against both Gram-positive and Gram-negative bacteria. Covering the modified membrane surface by an abiotic alginate layer resulted in a loss of antibacterial efficiency by 86.2%. In contrast, the antibacterial efficiency was maintained after developing a biofilm of Staphylococcus aureus of 30 μm in thickness. The current study may suggest that bacteria affected by contact-killing might interact with other bacteria in the vicinity, resulting in retarded biofilm growth. The antibiofouling effect and associated mechanism of the QAC modified membrane were further validated in a membrane bioreactor during long-term operation. PMID:27104660

  13. Recent Advances in Directed Assembly of Nanowires or Nanotub es

    Institute of Scientific and Technical Information of China (English)

    Mei Liu; Zhizheng Wu; Woon Ming Lau; Jun Yang

    2012-01-01

    Nanowires and nanotubes of diverse material compositions, properties and/or functions have been produced or fabricated through various bottom-up or top-down approaches. These nanowires or nanotubes have also been utilized as potential building blocks for functional nanodevices. The key for the integration of those nanowire or nanotube based devices is to assemble these one dimensional nanomaterials to specific locations using techniques that are highly controllable and scalable. Ideally such techniques should enable assembly of highly uniform nanowire/nanotube arrays with precise control of density, location, dimension or even ma-terial types of nanowires/nanotubes. Numerous assembly techniques are being developed that can quickly align and assemble large quantities of one type or multiple types of nanowires through parallel processes, in-cluding flow-assisted alignment, Langmuir-Blodgett assembly, bubble-blown technique, electric/magnetic- field directed assembly, contact/roll printing, knocking-down, etc.. With these assembling techniques, applications of nanowire/nanotube based devices such as flexible electronics and sensors have been demonstrated. This paper delivers an overall review of directed nanowire/nanotube assembling approaches and analyzes advantages and limitations of each method. The future research directions have also been discussed.

  14. Direct determination of contact angles of model soils in comparison with wettability characterization by capillary rise

    Science.gov (United States)

    Ramírez-Flores, Juan Carlos; Bachmann, Jörg; Marmur, Abraham

    2010-03-01

    SummaryAn accurate method to determine contact angles (CA) of soils as a measure of water repellency is still missing. In the present research, we evaluated and compared different methods to determine the CA of dry soil samples. Experiments were made by using a set of porous materials (silt, sand and glass beads) with different levels of water repellency. The CAs were measured with the Capillary Rise Method ( θCRM; liquid penetration into a 3-d system), the Wilhelmy plate method ( θWPM; measurement of capillary forces acting on a plane sample) and the Sessile Drop Method ( θSDM; optical CA analysis of drop contour on a plane sample). Results were compared with the CAs calculated from capillary rise in long vertical columns ( θECR), where liquid profiles of the final capillary rise of water and ethanol, respectively, were used to derive the contact angle under the assumed equilibrium conditions. The results showed the overestimation of the CA by using the well established bi-liquid CRM technique for porous materials, in particular for material with a low degree of water repellency (CA < 40°) and for the finer textured materials. In contrast, a variant of the Wilhelmy plate method, i.e. the cosine-averaged advancing CA and receding CA ( θEWPM), as well as the Sessile Drop CA, θSDM, were close to the ones of θECR. We concluded that θEWPM and θSDM are apparent CA, but nevertheless able to predict the impact of wettability on the final capillary rise which is affected by pore topology as well as by wettability.

  15. Development of a Direct Contact Heat Exchanger, Phase 1 Study Report

    Science.gov (United States)

    Manvi, R.

    1978-01-01

    Electric power generation from geothermal brine requires, first, bringing the hot brine to the surface and then converting the heat to electric power. Binary conversion schemes were proposed, with the heat transfer between the brine and the working organic fluid taking place in a conventional tube and shell heat exchanger. If the brine is heavily laden with dissolved solids, however, solids buildup on the heat exchanger surfaces leads to a considerable degree of fouling and an accompanying drop in performance is experienced. A possible solution to this problem is the use of a direct contact exchanger with the secondary fluid power cycle. The proposed concept involves the formation of fluid sheets and bells as heat angles. Results of a study concerning the fluid mechanics of such surfaces are given.

  16. Real time optimization of solar powered direct contact membrane distillation based on multivariable extremum seeking

    KAUST Repository

    Karam, Ayman M.

    2015-09-21

    This paper presents a real time optimization scheme for a solar powered direct contact membrane distillation (DCMD) water desalination system. The sun and weather conditions vary and are inconsistent throughout the day. Therefore, the solar powered DCMD feed inlet temperature is never constant, which influences the distilled water flux. The problem of DCMD process optimization has not been studied enough. In this work, the response of the process under various feed inlet temperatures is investigated, which demonstrates the need for an optimal controller. To address this issue, we propose a multivariable Newton-based extremum seeking controller which optimizes the inlet feed and permeate mass flow rates as the feed inlet temperature varies. Results are presented and discussed for a realistic temperature profile.

  17. Effect of pool turbulence on direct contact condensation at a steam/water interface

    International Nuclear Information System (INIS)

    Measurements of direct contact condensation beat transfer have been made for the case where the process takes place at the horizontal interface between saturated steam and a pool of water in a vertical cylindrical test section. A submerged vertical jet of subcooled water was injected upwards on the axis to promote the condensation and water was withdrawn at the same rate from the bottom of the pool. In conjunction with the above study, measurements of the turbulent velocity fluctuations just below a free surface produced by the injection of a vertical submerged jet have been measured using hot film anemometry on an isothermal air-water test facility of similar geometry for similar flow conditions at ambient temperature. A correlation is proposed in terms of a Stanton number based on turbulent velocity fluctuation near the interface on the liquid-side. Our results are in good agreement with those of others for similar configurations when compared in terms of condensation Stanton number. (author)

  18. Point-contact Andreev-reflection spectroscopy in anisotropic superconductors: the importance of directionality (Review Article)

    International Nuclear Information System (INIS)

    Point-contact Andreev-reflection spectroscopy (PCARS) has demonstrated to be one of the most effective experimental tools for the investigation of fundamental properties of superconductors such as the superconducting gap and the electron-phonon (or, more generally, electron-boson) coupling. By reviewing relevant examples reported in literature and presenting new results, in this paper we show that when the direction of the interface with respect to the crystallographic axes can be controlled (as in single crystals and epitaxial films) PCARS can provide invaluable information about the anisotropy of the pairing wavefunction or - in the case of multiband superconductors - on the number, amplitude and symmetry of the energy gaps. Moreover, the analysis of PCARS results within a suitable 3D generalization of the BTK model allows obtaining qualitative information about the topology of the Fermi surface.

  19. Computational simulations of direct contact condensation as the driving force for water hammer

    International Nuclear Information System (INIS)

    An analysis, based on Computer Simulations of the Direct Contact Condensation as the Driving Force for the Condensation Induced Water Hammer phenomenon is performed within this thesis. The goal of the work is to develop a mechanistic HTC model, with predictive capabilities for the simulation of horizontal or nearly horizontal two-phase ows with complex patterns including the e ect of interfacial heat and mass transfer. The newly developed HTC model was implemented into the system code ATHLET and into the CFD tools ANSYS CFX and OpenFOAM. Validation calculations have been performed for horizontal or nearly horizontal ows, where simulation results have been compared against the local measurement data such as void and temperature or area averaged data delivered by a wire mesh sensor.

  20. Computational simulations of direct contact condensation as the driving force for water hammer

    Energy Technology Data Exchange (ETDEWEB)

    Ceuca, Sabin-Cristian

    2015-04-27

    An analysis, based on Computer Simulations of the Direct Contact Condensation as the Driving Force for the Condensation Induced Water Hammer phenomenon is performed within this thesis. The goal of the work is to develop a mechanistic HTC model, with predictive capabilities for the simulation of horizontal or nearly horizontal two-phase ows with complex patterns including the e ect of interfacial heat and mass transfer. The newly developed HTC model was implemented into the system code ATHLET and into the CFD tools ANSYS CFX and OpenFOAM. Validation calculations have been performed for horizontal or nearly horizontal ows, where simulation results have been compared against the local measurement data such as void and temperature or area averaged data delivered by a wire mesh sensor.

  1. Measurement of mass transfer coefficient in direct contact sulfuric acid concentration for IS process

    International Nuclear Information System (INIS)

    Hydrogen is expected to serve as a clean secondary energy, because it can be manufactured from water, used in a variety of energy end-use sectors as fuel, and returned to water after burning. For the realization of hydrogen energy system, development of efficient and economical hydrogen production methods is required to meet the future huge demand of hydrogen. The Iodine-Sulfur (IS) process is a promising candidate of such hydrogen production methods, in which water reacts with iodine and sulfur dioxide to produce hydrogen iodide and sulfuric acid (Bunsen reaction) and the produced acids are then decomposed to produce hydrogen and oxygen, respectively. This study is concerned with the development of IS process equipment named direct contact sulfuric acid concentrator, in which gaseous mixture produced by thermal decomposition of sulfuric acid contacts directly with sulfuric acid solution. In the concentrator, the high temperature heat of the decomposed gas is recovered and used to concentrate sulfuric acid solution and, at the same time, the undecomposed sulfuric acid is condensed and separated from the decomposition products of sulfur dioxide and oxygen. Although the concept is very attractive from the viewpoint of the development of compact and efficient sulfuric acid concentrator, little is known on the heat and mass transfer relevant to the concentrator. Therefore, experimental methods were discussed to acquire the gas-phase mass transfer coefficient required for the optimal design of the concentrator. Assuming the use of wetted-wall column and also of the sulfuric acid of azeotropic composition as the test solution which could eliminate the liquid-phase mass transfer resistance, the column specification and the measurement conditions were determined by which flooding could be avoided and surface wetting could be assured, as well. (author)

  2. Numerical modelling of low-Reynolds number direct contact condensation in a suppression pool test facility

    International Nuclear Information System (INIS)

    Highlights: • A low-Reynolds number direct contact condensation mode was simulated. • Eulerian two-fluid approach was used without interfacial tracking. • The numerical results were validated with the steam blowdown test. • The surface divergence model predicted the condensation phenomena satisfactory. - Abstract: In the safety pressure suppression pool systems of Boiling Water Reactors (BWRs), the condensation rate has to be maintained high enough in order to fulfill their safety function. A major part of this condensation occurs as direct contact condensation (DCC), which governs different modes varying from vigorous chugging of collapsing bubbles to mild condensation on almost flat steam–water interface. This paper discusses the Computational Fluid Dynamics (CFD) simulations of the latter, low-Reynolds number weak condensation regime. The numerical simulations were performed with two CFD codes, NEPTUNECFD and OpenFOAM, in which the DCC phenomenon was modelled by using the Eulerian two-fluid approach of interpenetrating continua without interfacial tracking. The interfacial heat transfer between steam and water was modelled by using the DCC models based on the surface renewal and the surface divergence theories. Flow turbulence was solved by employing the standard k–∊ turbulence model. The CFD results of this study were validated against the test results of the POOLEX facility of Lappeenranta University of Technology. In the reference test STB-31, the condensation phenomena were limited to only occur on a stable steam–water interface by very low steam mass flux applied and thermal insulation of the blowdown pipe. The simulation results demonstrated that the surface divergence model predicted the condensation phenomena quite accurately both qualitatively and quantitatively while the surface renewal model overestimated it strongly

  3. Studi Eksperimental Keausan Permukaan Material Akibat Adanya Multi-Directional Contact Friction

    Directory of Open Access Journals (Sweden)

    Muhammad Hasry

    2014-03-01

    Full Text Available Penelitian terkait keausan akibat gesekan satu arah dan gesekan dua arah sampai saat ini telah banyak dilakukan, tetapi hanya sedikit yang mengkaji keausan akibat gesekan banyak arah (multi-directional friction, padahal tidak sedikit suatu mekanisme mengakibatkan terjadinya multi-directional contact  friction, seperti pada kontak ban mobil terhadap jalan saat melakukan drifting ataupun pada sistem yang meggunakan ball joint. Data penelitian berupa data keausan merupakan hasil pengujian menggunakan tribometer tipe Pin-on-disk dengan material Ultra high molecular weight polyethylene (UHMWPE sebagai pin uji dan material Stainless steel sebagai disk. Pada pengujian, masing-masing pin dan disk bergerak rotasi dan saling kontak permukaan sehingga pada permukaan material terjadi gesekan ke arah yang berubah-ubah sepanjang waktu. Secara garis besar penelitian dilakukan dalam 2 macam, yaitu penelitian keausan akibat gesekan tanpa pelumasan (dry sliding dan dengan pelumasan (wet sliding. Sebagai data pembanding, diambil juga data keausan akibat dari gesekan satu arah, yaitu dengan menggerakkan disk secara rotasi sedangkan pin hanya mengalami pembebanan dan tidak bergerak sama sekali. Permukaan spesimen yang telah diuji selanjutnya diamati struktur permukaannya menggunakan mikroskop optis dengan perbesaran 100 kali. Hasil dari penelitian menyebutkan bahwa gesekan banyak arah (Multi-Directional Friction akan menghasilkan keausan yang lebih besar dibanding gesekan satu arah (Uni-Directional Friction. Material yang mengalami gesekan banyak arah dengan pembebanan statis sebesar 39.2 N dan dengan kecepatan sesaat yang berubah-ubah mulai dari nol sampai 19.546 m/menit, akan mengalami keausan dengan mekanisme abrasi. Berdasarkan penelitian diketahui juga bahwa adanya pelumas memberi pengaruh yang besar dalam mengurangi keausan.

  4. Advance directives, dementia, and physician-assisted death.

    Science.gov (United States)

    Menzel, Paul T; Steinbock, Bonnie

    2013-01-01

    Physician-assisted suicide laws in Oregon and Washington require the person's current competency and a prognosis of terminal illness. In The Netherlands voluntariness and unbearable suffering are required for euthanasia. Many people are more concerned about the loss of autonomy and independence in years of severe dementia than about pain and suffering in their last months. To address this concern, people could write advance directives for physician-assisted death in dementia. Should such directives be implemented even though, at the time, the person is no longer competent and would not be either terminally ill or suffering unbearably? We argue that in many cases they should be, and that a sliding scale which considers both autonomy and the capacity for enjoyment provides the best justification for determining when: when written by a previously well-informed and competent person, such a directive gains in authority as the later person's capacities to generate new critical interests and to enjoy life decrease. Such an extension of legalized death assistance is grounded in the same central value of voluntariness that undergirds the current more limited legalization. PMID:23802899

  5. Emergency nurses' knowledge, attitudes, and experiential survey on advance directives.

    Science.gov (United States)

    Jezewski, Mary Ann; Feng, Jui-Ying

    2007-08-01

    The purpose of this study was to determine emergency nurses' knowledge of, attitudes toward, and experiences with advance directives (ADs). This was a descriptive, correlation, mailed survey study sent to a random sample of members of the Emergency Nurses Association. The results, based on the responses of 579 emergency nurses, found that the nurses were not very knowledgeable about ADs in general (68% correct) and even less knowledgeable about the Patient Self-Determination Act (PSDA) (51% correct) and their state laws (56% correct). The nurses were experienced with ADs but they were less confident in their ability to assist patients with completing ADs. Forty-seven percent of the nurses agreed that actively assisting some terminally ill patients to die should be made legal. Nurses need information pertaining to ADs in general, the PSDA, and their individual state laws. This could increase their level of confidence in being able to effectively assist patients to understand and complete ADs. PMID:17693216

  6. An assessment of the use of direct contact condensers with wet cooling systems for utility steam power plants

    Energy Technology Data Exchange (ETDEWEB)

    Bharathan, D; Hoo, E [National Renewable Energy Lab., Golden, CO (United States); D`Errico, P [Stone and Webster Engineering Corp., Boston, MA (United States)

    1992-02-01

    Potential use of a direct contact condenser for steam recovery at the turbine exhaust of a utility power plant using a wet cooling system is investigated. To maintain condensate separate from the cooling water, a bank of plate heat exchangers is used. In a case study for a nominal 130-MW steam power plant, two heat rejection systems, one using a conventional surface condenser and another using a direct contact condenser together with a set of plate heat exchangers are compared on the basis of their performance, operation and maintenance, and system economics. Despite a higher initial cost for the direct contact system, the advantages it offers suggests that this system is viable both technically and economically. Key to the improvements the direct contact system offers is a higher equivalent availability for the power system. Reduction of dissolved oxygen and other metallic ions in the condensate, reduced use of chemical scavengers and polishers, and potential elimination of a plant floor are also major benefits of this system. Drawbacks include added plant components and higher initial cost. The potential for long-term cost reduction for the direct contact system is also identified.

  7. Two-stage scaling methodology and direct contact condensation of the core makeup tank in a passive PWR

    International Nuclear Information System (INIS)

    Center for Advanced Reactor Research has developed a passive PWR concept called CARR passive reactor 1300MWe(CP-1300). The CP-1300 has new passive safety features. It is necessary to study the performance of the new safety feature and their interactions in order to assess the response of the CP-1300 under postulated accident conditions. Since it is not feasible to build and test a full power prototype system, a scaled-down integral facility is the best alternative. Therefore, it is necessary to have a rational scaling method. To the end, a two-stage scaling method with validation of scaling methodology is developed for a full-pressure full height scaled-down integral test facility simulating a small-break loss-of-coolant accident in the CP-1300. The present scaling method consists of two stages: scaling methodology stage and validation stage of the scaling methodology and a safety analysis code. In the scaling methodology stage, the whole system and the transient scenario are divided into several subsystems and several phases, respectively. For each subsystem potentially important phenomena are identified and ranked in terms of their relative importance for each phase. The global governing equations for each subsystem are nondimensionalized and expressed as nonlinear integral response functions with nondimensional scaling parameters. In the validation stage of code and scaling methodology the system code is assessed to identify little-known phenomena with high relative importance. The direct contact condensation in the CMT is identified as a little-known phenomenon with high importance. The scaling method is validated through comparison of the key parameters of the model and the prototype using the improved code. For full-height full-pressure scaling it is found out that the power scaling ratio is the same as the volume scaling ratio and the area scaling ratio and the horizontal pipes including the surge line are scaled by an exponent 2/5 of the scaling ratio. If

  8. Recovery Act: Advanced Direct Methanol Fuel Cell for Mobile Computing

    Energy Technology Data Exchange (ETDEWEB)

    Fletcher, James H. [University of North Florida; Cox, Philip [University of North Florida; Harrington, William J [University of North Florida; Campbell, Joseph L [University of North Florida

    2013-09-03

    ABSTRACT Project Title: Recovery Act: Advanced Direct Methanol Fuel Cell for Mobile Computing PROJECT OBJECTIVE The objective of the project was to advance portable fuel cell system technology towards the commercial targets of power density, energy density and lifetime. These targets were laid out in the DOE’s R&D roadmap to develop an advanced direct methanol fuel cell power supply that meets commercial entry requirements. Such a power supply will enable mobile computers to operate non-stop, unplugged from the wall power outlet, by using the high energy density of methanol fuel contained in a replaceable fuel cartridge. Specifically this project focused on balance-of-plant component integration and miniaturization, as well as extensive component, subassembly and integrated system durability and validation testing. This design has resulted in a pre-production power supply design and a prototype that meet the rigorous demands of consumer electronic applications. PROJECT TASKS The proposed work plan was designed to meet the project objectives, which corresponded directly with the objectives outlined in the Funding Opportunity Announcement: To engineer the fuel cell balance-of-plant and packaging to meet the needs of consumer electronic systems, specifically at power levels required for mobile computing. UNF used existing balance-of-plant component technologies developed under its current US Army CERDEC project, as well as a previous DOE project completed by PolyFuel, to further refine them to both miniaturize and integrate their functionality to increase the system power density and energy density. Benefits of UNF’s novel passive water recycling MEA (membrane electrode assembly) and the simplified system architecture it enabled formed the foundation of the design approach. The package design was hardened to address orientation independence, shock, vibration, and environmental requirements. Fuel cartridge and fuel subsystems were improved to ensure effective fuel

  9. Theoretical and Statistical Models for Predicting Flux in Direct Contact Membrane Distillation

    Directory of Open Access Journals (Sweden)

    Atia E. Khalifa

    2014-06-01

    Full Text Available Theoretical modelhas been applied to predict the performance of Direct Contact Membrane Distillation (DCMD based on the analysis of heat and mass transfer through the membrane. The performance of DCMD on the account of different operating parameters had been predicted. Feed inlet temperature, coolant inlet temperature, feed flow rate and coolant flow rate are the considered performance variables. Based on the data obtained from theoretical model, statistical analysis of variance (ANOVA was then performed to determine the significant effect of each operating factors on the DCMD system performance. A new regression model was subsequently developed for predicting the performance of the DCMD system. Resultsrevealed that both theoretical and regression models were in good agreement with each other and also with the selected experimental data used for validation. The maximum percentage error between the two models was found to be1.098%. Hence, the developed regression model is adequate for predict the performance of DCMD system within the domain of the considered analysis.

  10. Performance modeling of direct contact membrane distillation (DCMD) seawater desalination process using a commercial composite membrane

    KAUST Repository

    Lee, Junggil

    2015-01-10

    This paper presents the development of a rigorous theoretical model to predict the transmembrane flux of a flat sheet hydrophobic composite membrane, comprising both an active layer of polytetrafluoroethylene and a scrim-backing support layer of polypropylene, in the direct contact membrane distillation (DCMD) process. An integrated model includes the mass, momentum, species and energy balances for both retentate and permeate flows, coupled with the mass transfer of water vapor through the composite membrane and the heat transfer across the membrane and through the boundary layers adjacent to the membrane surfaces. Experimental results and model predictions for permeate flux and performance ratio are compared and shown to be in good agreement. The permeate flux through the composite layer can be ignored in the consideration of mass transfer pathways at the composite membrane. The effect of the surface porosity and the thickness of active and support layers on the process performance of composite membrane has also been studied. Among these parameters, surface porosity is identified to be the main factor significantly influencing the permeate flux and performance ratio, while the relative influence of the surface porosity on the performance ratio is less than that on flux.

  11. Dynamic modeling and experimental validation for direct contact membrane distillation (DCMD) process

    KAUST Repository

    Eleiwi, Fadi

    2016-02-01

    This work proposes a mathematical dynamic model for the direct contact membrane distillation (DCMD) process. The model is based on a 2D Advection–Diffusion Equation (ADE), which describes the heat and mass transfer mechanisms that take place inside the DCMD module. The model studies the behavior of the process in the time varying and the steady state phases, contributing to understanding the process performance, especially when it is driven by intermittent energy supply, such as the solar energy. The model is experimentally validated in the steady state phase, where the permeate flux is measured for different feed inlet temperatures and the maximum absolute error recorded is 2.78 °C. Moreover, experimental validation includes the time variation phase, where the feed inlet temperature ranges from 30 °C to 75 °C with 0.1 °C increment every 2min. The validation marks relative error to be less than 5%, which leads to a strong correlation between the model predictions and the experiments.

  12. Characterization of direct contact condensation of steam jets discharging into a subcooled water

    International Nuclear Information System (INIS)

    Direct contact condensation of steam jets discharging into a subcooled pool water has been experimentally investigated using five different sizes of horizontal nozzle over a wide range of steam mass flux and pool temperature conditions. Condensation phenomena have been observed visually and by taking pictures of steam jets using a video camera. Three kinds of steam jet shape were typically observed, which are dependent on the steam mass flux and pool temperature. The jet expansion ratio and the jet length as well as the condensation heat transfer coefficients were determined. The effect of steam mass flux, pool temperature, and nozzle diameter on these parameters were also discussed. The axial and radial temperature distributions in steam jet and in surrounding pool water as well as the dynamic pressure at the tank wall were measured under various test conditions. In addition, the relation between steam condensation and dynamic pressure at the tank wall was also discussed, which is dependent also on the steam mass flux and pool temperature. (author)

  13. Study of Direct-Contact HfO2/Si Interfaces

    Directory of Open Access Journals (Sweden)

    Noriyuki Miyata

    2012-03-01

    Full Text Available Controlling monolayer Si oxide at the HfO2/Si interface is a challenging issue in scaling the equivalent oxide thickness of HfO2/Si gate stack structures. A concept that the author proposes to control the Si oxide interface by using ultra-high vacuum electron-beam HfO2 deposition is described in this review paper, which enables the so-called direct-contact HfO2/Si structures to be prepared. The electrical characteristics of the HfO2/Si metal-oxide-semiconductor capacitors are reviewed, which suggest a sufficiently low interface state density for the operation of metal-oxide-semiconductor field-effect-transistors (MOSFETs but reveal the formation of an unexpected strong interface dipole. Kelvin probe measurements of the HfO2/Si structures provide obvious evidence for the formation of dipoles at the HfO2/Si interfaces. The author proposes that one-monolayer Si-O bonds at the HfO2/Si interface naturally lead to a large potential difference, mainly due to the large dielectric constant of the HfO2. Dipole scattering is demonstrated to not be a major concern in the channel mobility of MOSFETs.

  14. Experimental and Analytical Study of Lead-Bismuth-Water Direct Contact Boiling Two-Phase Flow

    Science.gov (United States)

    Novitrian; Dostal, Vaclav; Takahashi, Minoru

    The characteristics of lead-bismuth(Pb-Bi)-water boiling two-phase flow were investigated experimentally and analytically using a Pb-Bi-water direct contact boiling two-phase flow loop. Pb-Bi flow rates and void fraction were measured in a vertical circular tube at conditions of system pressure 7MPa, liquid metal temperature 460°C and injected water temperature 220°C. The drift-flux model with the assumption that bubble sizes were dependent on the fluid surface tension and the density ratio of Pb-Bi to steam-water mixture was chosen and modified by the best fit to the measured void fraction. Pb-Bi flow rates were analytically estimated using balance condition between buoyancy force and pressure losses, where the buoyancy force was calculated from void fraction estimated using the modified drift-flux model. The deviation of the analytical results of the flow rates from the experimental ones was less than 10%.

  15. Advance directives for non-therapeutic dementia research: some ethical and policy considerations.

    OpenAIRE

    Berghmans, R L

    1998-01-01

    This paper explores the use of advance directives in clinical dementia research. The focus is on advance consent to participation of demented patients in non-therapeutic research involving more than minimal risks and/or burdens. First, morally relevant differences between advance directives for treatment and care, and advance directives for dementia research are discussed. Then attention is paid to the philosophical issue of dementia and personal identity, and the implications for the moral a...

  16. Fundamental issues, recent advances, and future directions in myodynamics.

    Science.gov (United States)

    Hatze, H

    2002-12-01

    A state-of-the-art report is presented on recent progress in selected areas of myodynamics, but also on problems that severely hamper the further development of the discipline. Significant advances have been made in elucidating the force-producing interaction between actin and the myosin-S1-subunit, including the localization of the most probable molecular site of power stroke initiation. Concerning the architecture of the myostructures, strong experimental evidence has accumulated for numerous intra-, inter-, and extramuscular pathways for lateral force transmission in addition to the serial sarcomere-to-sarcomere myotendinous path. It is shown that contemporary muscle models are inadequate in most respects and lag far behind the requirements an appropriate myodynamic model should fulfil. A similar comment applies to the current approaches designed to solve the myoskeletal indeterminacy problem. These formulations neglect myodynamic properties and do not allow for the implementation of biologically realistic objective functions. The solutions currently obtained are highly unsatisfactory. New research directions to rectify these situations are suggested, also with regard to the identification of subject-specific myodynamic parameters. PMID:12435541

  17. Recent Advances in PV Research and Future Directions

    Science.gov (United States)

    Deb, Satyen K.

    1998-04-01

    The photovoltaic technology is making a major thrust in the commercial arena with 1997 worldwide production of PV modules reaching over 125 MW and growing at the rate of 20-25semiconductor materials and devices are emerging as strong contenders for PV applications even though silicon is still the 'work-horse' of the industry. Ultra-high efficiency solar cells fabricated from gallium arsenide (GaAs) and its ternary alloys like gallium indium phosphide (GaInP2) are finding applications in space technology. Enormous progress has also been made on various thin-film solar cell technologies, which offer the promise for substantially reducing the cost of PV systems. Some of the leading contenders are amorphous and polycrystalline silicon, compound semiconductor thin films such as copper indium diselenide (CuInSe2) based alloys, and cadmium telluride (CdTe) thin films. Exciting new developments are happening in the use of nano-particle semiconductor materials like titanium dioxide (TiO2) for low-cost PV devices. Intense research on these and other materials and devices is making a strong impact on the technology. In this presentation, a brief overview of recent advances in PV research will b e made and the trends and opportunities for future research directions will be identified.

  18. Performance investigation of a solar-assisted direct contact membrane distillation system

    KAUST Repository

    Kim, Youngdeuk

    2013-01-01

    This paper presents a solar-assisted direct contact membrane distillation (DCMD) system with novel energy recovery concepts for a continuous 24-h-a-day operation. A temperature modulating scheme is introduced to the solar-thermal system that supplies feed seawater to the DCMD modules. This scheme attenuates extreme temperature fluctuations of the feed water by storing the collected energy during solar-peak hours and reutilizing it throughout the day. Thus, the energy savings is realized yet the feed seawater temperature is maintained within the desired range. Additionally, the system employs heat recovery from the permeate and brine streams to the feed seawater. The simulations for such a system with a shell-and-tube type DCMD modules are carried out to examine the spatial property variations and the sensitivity of system performance (i.e., transmembrane pressure, permeate flux and performance ratio) to the operating conditions (inlet temperature and flow rate) and the fiber dimensions (fiber length and packing density). It is found that there are trade-offs between mean permeate flux and performance ratio with respect to permeate inlet temperature and flow rate and between total distillate production and performance ratio with respect to packing density. For the solar-assisted DCMD system having evacuated-tube collectors of 3360m2 with 160m3 seawater storage tanks and 50 DCMD modules, the annual solar fraction and the collector efficiency are found to be 77% and 53%, respectively, whilst the overall permeate production capacity is 31m3/day. The overall specific thermal energy consumption of the DCMD system with heat recovery is found to be 436kWh/m3 and it is about 43% lower as compared to the system without heat recovery. It is observed that the specific thermal energy consumption decreases significantly by 55% with increased collector area from 1983m2 to 3360m2 whereas the specific electrical energy consumption increases slightly by 16%. © 2012 Elsevier B.V.

  19. Contact allergy to the 26 specific fragrance ingredients to be declared on cosmetic products in accordance with the EU cosmetics directive

    DEFF Research Database (Denmark)

    Heisterberg, Maria V; Menné, Torkil; Johansen, Jeanne D

    2011-01-01

    Background. Fragrance ingredients are a frequent cause of allergic contact dermatitis. The EU Cosmetics Directive states that 26 specific fragrance ingredients, known to cause allergic contact dermatitis, must be declared on the ingredient lists of cosmetic products. Objectives. To investigate...

  20. New Directions for NASA's Advanced Life Support Program

    Science.gov (United States)

    Barta, Daniel J.

    2006-01-01

    Exploration Life Support (ELS) Project, under the Exploration Technology Development Program, has recently been initiated to perform directed life support technology development in support of Constellation and the Crew Exploration Vehicle (CEV). ELS) has replaced ALS, with several major differences. Thermal Control Systems have been separated into a new stand alone project (Thermal Systems for Exploration Missions). Tasks in Advanced Food Technology have been relocated to the Human Research Program. Tasks in a new discipline area, Habitation Engineering, have been added. Research and technology development for capabilities required for longer duration stays on the Moon and Mars, including bioregenerative system, have been deferred.

  1. Direkte Kontakte zu Deutschland aus und in der Ferne (Direct Contact with Germany from and at a Distance).

    Science.gov (United States)

    Wicke, Rainer E.

    This guide is a summary of ideas for enhancing the teaching of German through direct contact with Germany or German people without traveling abroad. The following ideas are highlighted: (1) correspondence (pen pals) with students in Germany; (2) audiotape recordings as an alternative to letter writing; (3) the exchange of videotape recordings with…

  2. 77 FR 14022 - Guidance for Industry: Testing for Salmonella Species in Human Foods and Direct-Human-Contact...

    Science.gov (United States)

    2012-03-08

    ... 23, 2011 (76 FR 16425), FDA made available a draft guidance entitled ``Testing for Salmonella Species... HUMAN SERVICES Food and Drug Administration Guidance for Industry: Testing for Salmonella Species in Human Foods and Direct-Human-Contact Animal Foods; Availability AGENCY: Food and Drug...

  3. UTILITY OF MECHANISTIC MODELS FOR DIRECTING ADVANCED SEPARATIONS RESEARCH & DEVELOPMENT ACTIVITIES: Electrochemically Modulated Separation Example

    Energy Technology Data Exchange (ETDEWEB)

    Schwantes, Jon M.

    2009-06-01

    The objective for this work was to demonstrate the utility of mechanistic computer models designed to simulate actinide behavior for use in efficiently and effectively directing advanced laboratory R&D activities associated with developing advanced separations methods.

  4. Readability of state-sponsored advance directive forms in the United States: a cross sectional study

    OpenAIRE

    Mueller Paul S; Reid Kevin I; Mueller Luke A

    2010-01-01

    Abstract Background State governments provide preprinted advance directive forms to the general public. However, many adults in the United States (US) lack the skills necessary to read and comprehend health care-related materials. In this study, we sought to determine the readability of state government-sponsored advance directive forms. Methods A cross sectional study design was used. The readability of advance directive forms available online from all 50 US states and the District of Columb...

  5. Putin, Bush issue statement on advancing US-Russian human contacts

    CERN Multimedia

    2002-01-01

    "In addition to interstate, bilateral, regional and global issues discussed by Russian President Vladimir Putin and US President George Bush during their Kremlin summit on 24 May, the two leaders considered issues related to people-to-people contacts, ties between cities, states and regions, institutions and organizations" (1 page).

  6. Human exposure to trace elements through the skin by direct contact with clothing: Risk assessment

    Energy Technology Data Exchange (ETDEWEB)

    Rovira, Joaquim [Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, Sant Llorenç 21, 43201 Reus, Catalonia (Spain); Environmental Engineering Laboratory, Departament d' Enginyeria Quimica, Universitat Rovira i Virgili, Av. Països Catalans 26, 43007 Tarragona, Catalonia (Spain); Nadal, Martí [Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, Sant Llorenç 21, 43201 Reus, Catalonia (Spain); Schuhmacher, Marta [Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, Sant Llorenç 21, 43201 Reus, Catalonia (Spain); Environmental Engineering Laboratory, Departament d' Enginyeria Quimica, Universitat Rovira i Virgili, Av. Països Catalans 26, 43007 Tarragona, Catalonia (Spain); Domingo, José L., E-mail: joseluis.domingo@urv.cat [Laboratory of Toxicology and Environmental Health, School of Medicine, IISPV, Universitat Rovira i Virgili, Sant Llorenç 21, 43201 Reus, Catalonia (Spain)

    2015-07-15

    Metals in textile products and clothing are used for many purposes, such as metal complex dyes, pigments, mordant, catalyst in synthetic fabrics manufacture, synergists of flame retardants, antimicrobials, or as water repellents and odour-preventive agents. When present in textile materials, heavy metals may mean a potential danger to human health. In the present study, the concentrations of a number of elements (Al, As, B, Ba, Be, Bi, Cd, Co, Cr, Cu, Fe, Hg, Mg, Mn, Mo, Ni, Pb, Sb, Sc, Se, Sm, Sn, Sr, Tl, V, and Zn) were determined in skin-contact clothes. Analysed clothes were made of different materials, colours, and brands. Interestingly, we found high levels of Cr in polyamide dark clothes (605 mg/kg), high Sb concentrations in polyester clothes (141 mg/kg), and great Cu levels in some green cotton fabrics (around 280 mg/kg). Dermal contact exposure and human health risks for adult males, adult females, and for <1-year-old children were assessed. Non-carcinogenic and carcinogenic risks were below safe (HQ<1) and acceptable (<10{sup −6}) limits, respectively, according to international standards. However, for Sb, non-carcinogenic risk was above 10% of the safety limit (HQ>0.1) for dermal contact with clothes. - Highlights: • We determined in skin-contact clothes the concentrations of a number of metals. • Dermal contact exposure and health risks for adults and for 1-year-old children were assessed. • Carcinogenic risks were considered as acceptable (<10{sup −6}). • For non-carcinogenic risks, only Sb exceeded a 10% of the HQ for dermal contact with clothes.

  7. Human exposure to trace elements through the skin by direct contact with clothing: Risk assessment

    International Nuclear Information System (INIS)

    Metals in textile products and clothing are used for many purposes, such as metal complex dyes, pigments, mordant, catalyst in synthetic fabrics manufacture, synergists of flame retardants, antimicrobials, or as water repellents and odour-preventive agents. When present in textile materials, heavy metals may mean a potential danger to human health. In the present study, the concentrations of a number of elements (Al, As, B, Ba, Be, Bi, Cd, Co, Cr, Cu, Fe, Hg, Mg, Mn, Mo, Ni, Pb, Sb, Sc, Se, Sm, Sn, Sr, Tl, V, and Zn) were determined in skin-contact clothes. Analysed clothes were made of different materials, colours, and brands. Interestingly, we found high levels of Cr in polyamide dark clothes (605 mg/kg), high Sb concentrations in polyester clothes (141 mg/kg), and great Cu levels in some green cotton fabrics (around 280 mg/kg). Dermal contact exposure and human health risks for adult males, adult females, and for <1-year-old children were assessed. Non-carcinogenic and carcinogenic risks were below safe (HQ<1) and acceptable (<10−6) limits, respectively, according to international standards. However, for Sb, non-carcinogenic risk was above 10% of the safety limit (HQ>0.1) for dermal contact with clothes. - Highlights: • We determined in skin-contact clothes the concentrations of a number of metals. • Dermal contact exposure and health risks for adults and for 1-year-old children were assessed. • Carcinogenic risks were considered as acceptable (<10−6). • For non-carcinogenic risks, only Sb exceeded a 10% of the HQ for dermal contact with clothes

  8. The views of older Malaysians on advanced directive and advanced care planning: a qualitative study.

    Science.gov (United States)

    Htut, Y; Shahrul, K; Poi, P J H

    2007-01-01

    The provision of optimum care for the ageing population is dependent on the understanding of their views and values on end of life issues. A qualitative descriptive study was conducted to describe views of elderly Malaysians on Advanced Care Planning (henceforth ACP) and Advanced Directives (henceforth AD), and explore factors influencing these views. Fifteen elderly subjects with ages ranging from 65 to 83 years, representing different ethnic and religious groups in Malaysia were selected for in-depth interviews guided by a questionnaire. Five core themes were extracted from the interviews: 1) Considering the future 2) Contingency plans for future illnesses 3) Attitudes towards life prolonging treatment procedures 4) Doctor-patient relationships and 5) Influence of religion on decisions related to future illness. Despite the lack of knowledge on ACP and AD, older respondents were very receptive to their concept. Although the majority agreed on the importance of planning for future medical management and having open discussion on end of life issues with their doctor, they felt it unnecessary to make a formal written AD. Most felt that the future was best left to fate or God, and none had made any contingency plan for severe future illnesses citing religion as reason for this view. Cardiopulmonary resuscitation, mechanical ventilation and dialysis were considered by most to be invasive life prolonging treatments. We suggest that doctors initiate discussions on end of life care with every older patient and their family so as to promote awareness and introduce the concept of ACP/AD to a Malaysian setting. PMID:18330404

  9. Design and Experimental Study for Development of Pb-Bi Cooled Direct Contact Boiling Water Small Fast Reactor (PBWFR)

    International Nuclear Information System (INIS)

    A design concept of Pb-Bi cooled direct contact boiling water small fast reactor (PBWFR) has been formulated with some design parameters identified. In the PBWFR, water is injected into hot Pb-Bi above the core, and direct contact boiling takes place in the chimney. The boiling two-phase flow in the chimney serves as a steam lift pump and a steam generator. A two-region core is designed. A decrease in reactivity was estimated to be 1.5 % dk/kk' for 15 years. A fuel assembly has 271 fuel rods with 12.0 mm in diameter and 15.9 mm in pitch in a hexagonal wrapper tube. The chimney, cyclone separators and chevron dryers, direct heat exchangers (DHX), reactor vessel air cooling systems (RVACS) and guard vessel are designed. For the technical development of the PBWFR, experimental and analytical studies are performed for Pb-Bi direct contact boiling two-phase flow, steel corrosion in Pb-Bi flow, oxygen control and oxygen sensor, and removal of polonium contamination. (authors)

  10. Clonogenic growth of human breast cancer cells co-cultured in direct contact with serum-activated fibroblasts

    International Nuclear Information System (INIS)

    Accumulating evidence suggests that fibroblasts play a pivotal role in promoting the growth of breast cancer cells. The objective of the present study was to characterize and validate an in vitro model of the interaction between small numbers of human breast cancer cells and human fibroblasts. We measured the clonogenic growth of small numbers of human breast cancer cells co-cultured in direct contact with serum-activated, normal human fibroblasts. Using DNA microarrays, we also characterized the gene expression profile of the serum-activated fibroblasts. In order to validate the in vivo relevance of our experiments, we then analyzed clinical samples of metastatic breast cancer for the presence of myofibroblasts expressing α-smooth muscle actin. Clonogenic growth of human breast cancer cells obtained directly from in situ and invasive tumors was dramatically and consistently enhanced when the tumor cells were co-cultured in direct contact with serum-activated fibroblasts. This effect was abolished when the cells were co-cultured in transwells separated by permeable inserts. The fibroblasts in our experimental model exhibited a gene expression signature characteristic of 'serum response' (i.e. myofibroblasts). Immunostaining of human samples of metastatic breast cancer tissue confirmed that myofibroblasts are in direct contact with breast cancer cells. Serum-activated fibroblasts promote the clonogenic growth of human breast cancer cells in vitro through a mechanism that involves direct physical contact between the cells. This model shares many important molecular and phenotypic similarities with the fibroblasts that are naturally found in breast cancers

  11. A new technique for direct traceability of contact thermometry Co-C eutectic cells to the ITS-90

    Energy Technology Data Exchange (ETDEWEB)

    Failleau, G.; Deuzé, T.; Bourson, F.; Briaudeau, S.; Sadli, M. [Laboratoire Commun de Métrologie LNE-Cnam, 61 rue du Landy 93210 La Plaine Saint Denis (France)

    2013-09-11

    The eutectic Co-C melting point is a promising system to serve as a thermometric fixed-point in the temperature range above 1084.62 °C (copper freezing point). During the last decade, LNE-Cnam has developed and characterized some fixed-point devices, based on eutectic Co-C alloy, for applications to contact and radiation thermometry. Above 962 °C, the ITS-90 is realized by radiation thermometry by the extrapolation from a Ag, Au or Cu fixed point using the Planck law for radiation. So the only way for assigning a temperature in the scale to a Co-C cell (∼1324 °C) is by radiation thermometry. An indirect method is commonly used to assign a temperature to a high-temperature fixed point (HTFP) cell designed for contact thermometry is to fill a pyrometric cell with the same mixture as the contact thermometry cell. In this case, the temperature assigned to the pyrometric cell is attributed to the contact cell. This paper describes a direct method allowing the determination of the melting temperature realized by a 'contact thermometry' Co-C cell by comparison to a 'radiation thermometry' Co-C cell whose melting temperature was assigned in accordance to the scale by extrapolation from the Cu point. In addition, the same Co-C cell is studied with a standard Pt/Pd thermocouple.

  12. A new technique for direct traceability of contact thermometry Co-C eutectic cells to the ITS-90

    International Nuclear Information System (INIS)

    The eutectic Co-C melting point is a promising system to serve as a thermometric fixed-point in the temperature range above 1084.62 °C (copper freezing point). During the last decade, LNE-Cnam has developed and characterized some fixed-point devices, based on eutectic Co-C alloy, for applications to contact and radiation thermometry. Above 962 °C, the ITS-90 is realized by radiation thermometry by the extrapolation from a Ag, Au or Cu fixed point using the Planck law for radiation. So the only way for assigning a temperature in the scale to a Co-C cell (∼1324 °C) is by radiation thermometry. An indirect method is commonly used to assign a temperature to a high-temperature fixed point (HTFP) cell designed for contact thermometry is to fill a pyrometric cell with the same mixture as the contact thermometry cell. In this case, the temperature assigned to the pyrometric cell is attributed to the contact cell. This paper describes a direct method allowing the determination of the melting temperature realized by a 'contact thermometry' Co-C cell by comparison to a 'radiation thermometry' Co-C cell whose melting temperature was assigned in accordance to the scale by extrapolation from the Cu point. In addition, the same Co-C cell is studied with a standard Pt/Pd thermocouple

  13. Advanced health biotechnologies in Thailand: redefining policy directions

    Directory of Open Access Journals (Sweden)

    Velasco Román Pérez

    2013-01-01

    Full Text Available Abstract Background Thailand faces a significant burden in terms of treating and managing degenerative and chronic diseases. Moreover, incidences of rare diseases are rising. Many of these—such as diabetes, cancer, and inherited inborn metabolic diseases—have no definite treatments or cure. Meanwhile, advanced health biotechnology has been found, in principle, to be an effective solution for these health problems. Methods Qualitative approaches were employed to analyse the current situation and examine existing public policies related to advanced health biotechnologies in Thailand. The results of this analysis were then used to formulate policy recommendations. Results Our research revealed that the system in Thailand in relation to advanced health biotechnologies is fragmented, with multiple unaddressed gaps, underfunding of research and development (R&D, and a lack of incentives for the private sector. In addition, there are no clear definitions of advanced health biotechnologies, and coverage pathways are absent. Meanwhile, false advertising and misinformation are prevalent, with no responsible bodies to actively and effectively provide appropriate information and education (I&E. The establishment of a specialised institution to fill the gaps in this area is warranted. Conclusion The development and implementation of a comprehensive national strategic plan related to advanced health biotechnologies, greater investment in R&D and I&E for all stakeholders, collaboration among agencies, harmonisation of reimbursement across public health schemes, and provision of targeted I&E are specifically recommended.

  14. CFD simulation of direct contact condensation with ANSYS CFX using surface renewal theory based heat transfer coefficients

    Energy Technology Data Exchange (ETDEWEB)

    Wanninger, Andreas; Ceuca, Sabin Cristian; Macian-Juan, Rafael [Technische Univ. Muenchen, Garching (Germany). Dept. of Nuclear Engineering

    2013-07-01

    Different approaches for the calculation of Direct Contact Condensation (DCC) using Heat Transfer Coefficients (HTC) based on the Surface Renewal Theory (SRT) are tested using the CFD simulation tool ANSYS CFX. The present work constitutes a preliminary study of the flow patterns and conditions observed using different HTC models. A complex 3D flow pattern will be observed in the CFD simulations as well as a strong coupling between the condensation rate and the two-phase flow dynamics. (orig.)

  15. CFD simulation of direct contact condensation with ANSYS CFX using surface renewal theory based heat transfer coefficients

    International Nuclear Information System (INIS)

    Different approaches for the calculation of Direct Contact Condensation (DCC) using Heat Transfer Coefficients (HTC) based on the Surface Renewal Theory (SRT) are tested using the CFD simulation tool ANSYS CFX. The present work constitutes a preliminary study of the flow patterns and conditions observed using different HTC models. A complex 3D flow pattern will be observed in the CFD simulations as well as a strong coupling between the condensation rate and the two-phase flow dynamics. (orig.)

  16. Similarity of coupled heat and mass transfer between air-water and air-liquid desiccant direct-contact systems

    Energy Technology Data Exchange (ETDEWEB)

    Liu, Xiao-Hua; Jiang, Yi [Department of Building Science, School of Architecture, Tsinghua University, Beijing 100084 (China); Li, Zhen [Department of Engineering Mechanics, Tsinghua University, Beijing 100084 (China)

    2009-12-15

    Packed-bed heat and mass transfer devices are widely used in air-conditioning systems, such as cooling tower, evaporative cooler of air-water direct-contact devices, dehumidifier and regenerator of air-liquid desiccant direct-contact devices. Similarities of heat and mass transfer characteristics between air-water and air-liquid desiccant devices are considered and investigated in this paper. Same reachable handling region of outlet air can be obtained for both air-water and air-liquid desiccant devices, which is among three boundary lines, isenthalpic line of inlet air, iso-relative humidity line of inlet fluid (water or desiccant), and the connecting line of inlet statuses of air and fluid. Inlet conditions of air and fluid affect heat and mass transfer characteristics to some extent, so that a zonal method is proposed only according to the relative statuses of inlet air to inlet fluid. Four zones, dehumidification zones A, D and regeneration zones B, C, are divided for air-desiccant direct-contact devices. The first three zones A, B and C are divided for air-water direct-contact devices, with the same zonal properties as those of air-desiccant devices. In order to obtain better humidification performance, fluid should be heated (in zone C) rather than air (in zone B). And fluid should be cooled (in zone A) rather than air (in zone D) to obtain better dehumidification performance. Counter-flow pattern should be applied for best mass transfer performance in the same conditions within the recommended zone A or C, while parallel-flow pattern is the best in zone B or D. (author)

  17. Variations in Consumer Self-Determination within US Psychiatric Advance Directives

    Science.gov (United States)

    Zeman, Laura Dreuth; Swanke, Jayme

    2008-01-01

    Advance directives are legal documents that formalize consumer psychiatric care preferences. This article examines the statutes and goals of US psychiatric advance directives within the framework of consumer self-determination, a priority in national mental health reform. It seeks to distinguish between state models based on the degree that…

  18. Effect of Health Literacy on the Utilization of Advance Directives Based on the Health Belief Model

    Science.gov (United States)

    Henkelman, Wallace J.

    2010-01-01

    Research has demonstrated that only a small proportion of individuals in the United States complete advance directives as part of their planning for end-of-life care. This study sought to determine if health literacy is a significant factor in advance directive completion as has been posited by previous researchers. Analysis of the data collected…

  19. Heat and momentum transfer mechanisms under the direct-contact-condensation between supersonic steam flow and water jet

    International Nuclear Information System (INIS)

    Steam injector (SI) is a passive jet pump which operates without rotating machineries and a high efficiency heat exchanger driven by the direct-contact-condensation phenomena between a supersonic steam flow and a water jet. The objective of this study is to elucidate the mechanisms of the heat and momentum transfer phenomena, as well as to investigate the effect of interfacial behavior on heat and momentum transfer characteristics induced by direct-contact condensation phenomena. In the present study, a transparent test section of SI was adopted to observe the flow structure with a high speed video camera. In addition, special measurement instrumentations of temperature and total pressure were applied to obtain radial distribution of temperature and flow velocity in the mixing nozzle. Several indicators of heat and momentum transfer characteristics were estimated from those measurement results. Additionally, complex wavy behavior on the water jet surface was observed and quantified with the image processing technique and correlation method, and the velocity were correlated against inlet conditions such as inlet water and steam flow rate. Heat transfer characteristics between the flows were well described with Nusselt number and Jacob number, furthermore, it was confirmed that there was correlation between momentum transfer characteristics and interfacial behavior, which was reasonably described with the correlation of slip ratio between the flows and interfacial wave velocity. Mechanisms of heat and momentum transfer induced with the direct-contact-condensation mediated with complex interfacial behavior are discussed from those experimental results. (author)

  20. Thermal design of a lead-bismuth cooled fast reactor with in vessel direct-contact steam generation

    International Nuclear Information System (INIS)

    The choice of lead or lead alloys as the coolant of a fast reactor offers enhanced safety and reliability due to their benign physical and chemical characteristics. In an effort to make this class of coolants even more attractive for the nuclear systems of the next generation, an innovative fast reactor concept that eliminates the need for steam generators and main coolant pumps and thus offers potential capital and operating cost reduction was explored. The primary coolant is lead-bismuth eutectic, which flows through the core and removed the heat generated by fission in the fuel. Slightly subcooled water is injected into the hot primary coolant pool above the core. The direct contact heat transfer between the fluids causes water to rapidly vaporize leading to the formation of steam bubbles in the reactor chimney. Simple modeling of the multi-phase phenomena occurring in the chimney of a Pb-Bi/water direct contact heat transfer reactor was undertaken. Benchmarking against limited available data demonstrated that the model captures the essential nature of direct contact heat transfer. The model was then used to establish a design envelope for the reactor power, chimney height and steam superheat on the basis of the fuel, clad and vessel temperature limits. A 1260 MWth power is found possible for 10 meters chimney height and 25 Celsius degrees superheat

  1. Thermal design of a lead-bismuth cooled fast reactor with in vessel direct-contact steam generation

    Energy Technology Data Exchange (ETDEWEB)

    Buongiomo, J. [Idaho National Engineering and Environmental Lab., Nuclear Engineering Dept., Idaho Falls, ID (United States); Todreas, N.E.; Kazimi, M.S. [Massachusetts Institute of Technology, Nuclear Engineering Dept., Cambridge, MA (United States)

    2001-07-01

    The choice of lead or lead alloys as the coolant of a fast reactor offers enhanced safety and reliability due to their benign physical and chemical characteristics. In an effort to make this class of coolants even more attractive for the nuclear systems of the next generation, an innovative fast reactor concept that eliminates the need for steam generators and main coolant pumps and thus offers potential capital and operating cost reduction was explored. The primary coolant is lead-bismuth eutectic, which flows through the core and removed the heat generated by fission in the fuel. Slightly subcooled water is injected into the hot primary coolant pool above the core. The direct contact heat transfer between the fluids causes water to rapidly vaporize leading to the formation of steam bubbles in the reactor chimney. Simple modeling of the multi-phase phenomena occurring in the chimney of a Pb-Bi/water direct contact heat transfer reactor was undertaken. Benchmarking against limited available data demonstrated that the model captures the essential nature of direct contact heat transfer. The model was then used to establish a design envelope for the reactor power, chimney height and steam superheat on the basis of the fuel, clad and vessel temperature limits. A 1260 MWth power is found possible for 10 meters chimney height and 25 Celsius degrees superheat.

  2. Method for analyzing the chemical composition of liquid effluent from a direct contact condenser

    Energy Technology Data Exchange (ETDEWEB)

    Bharathan, Desikan (Lakewood, CO); Parent, Yves (Golden, CO); Hassani, A. Vahab (Golden, CO)

    2001-01-01

    A computational modeling method for predicting the chemical, physical, and thermodynamic performance of a condenser using calculations based on equations of physics for heat, momentum and mass transfer and equations of equilibrium thermodynamics to determine steady state profiles of parameters throughout the condenser. The method includes providing a set of input values relating to a condenser including liquid loading, vapor loading, and geometric characteristics of the contact medium in the condenser. The geometric and packing characteristics of the contact medium include the dimensions and orientation of a channel in the contact medium. The method further includes simulating performance of the condenser using the set of input values to determine a related set of output values such as outlet liquid temperature, outlet flow rates, pressures, and the concentration(s) of one or more dissolved noncondensable gas species in the outlet liquid. The method may also include iteratively performing the above computation steps using a plurality of sets of input values and then determining whether each of the resulting output values and performance profiles satisfies acceptance criteria.

  3. A survey of stakeholder knowledge, experience, and opinions of advance directives for mental health in Virginia.

    Science.gov (United States)

    Wilder, Christine M; Swanson, Jeffrey W; Bonnie, Richard J; Wanchek, Tanya; McLaughlin, Laura; Richardson, Jeanita

    2013-05-01

    An innovative Virginia health care law enables competent adults with serious mental illness to plan for treatment during incapacitating crises using an integrated advance directive with no legal distinction between psychiatric or other causes of decisional incapacity. This article reports results of a survey of 460 individuals in five stakeholder groups during the initial period of the law's implementation. All respondents held favorable views of advance directives for mental health care. Identified barriers to completing and using advance directives varied by group. We conclude that relevant stakeholders support implementation of advance directives for mental health, but level of baseline knowledge and perception of barriers vary. A multi-pronged approach will be needed to achieve successful implementation of advance directives for mental health. PMID:22240937

  4. Advanced characterization of carrier profiles in germanium using micro-machined contact probes

    DEFF Research Database (Denmark)

    Clarysse, T.; Konttinen, M.; Parmentier, B.;

    2012-01-01

    The accurate determination of the sheet resistance and carrier depth profile, i.e. active dopant profile, of shallow junction isolated structures involving new high mobility materials, such as germanium, is a crucial topic for future CMOS development. In this work, we discuss the capabilities of...... use of only two probes, a spreading resistance like setup is obtained with small spacing and drastically reduced electrical contact radii (~10 nm) leading to a substantial reduction of the correction factors which are normally required for converting spreading resistance profiles. We demonstrate the...

  5. Advanced Gasoline Turbocharged Direction Injection (GTDI) Engine Development

    Energy Technology Data Exchange (ETDEWEB)

    Wagner, Terrance [Ford Motor Co., Dearborn, MI (United States)

    2015-12-31

    This program was undertaken in response to US Department of Energy Solicitation DE-FOA-0000079, resulting in a cooperative agreement with Ford and MTU to demonstrate improvement of fuel efficiency in a vehicle equipped with an advanced GTDI engine. Ford Motor Company has invested significantly in GTDI engine technology as a cost effective, high volume, fuel economy solution, marketed globally as EcoBoost technology. Ford envisions additional fuel economy improvement in the medium and long term by further advancing EcoBoost technology. The approach for the project was to engineer a comprehensive suite of gasoline engine systems technologies to achieve the project objectives, and to progressively demonstrate the objectives via concept analysis / computer modeling, single-cylinder and multi-cylinder engine testing on engine dynamometer, and vehicle level testing on chassis rolls.

  6. Clinical Performance of Toris K Contact Lens in Patients with Moderate to Advanced Keratoconus: A Real Life Retrospective Analysis

    Science.gov (United States)

    Yilmaz, Ihsan; Ozcelik, Ferah; Basarir, Berna; Demir, Gokhan; Durusoy, Gonul; Taskapili, Muhittin

    2016-01-01

    Objectives. To evaluate the visual performance of Toris K soft contact lenses in patients with moderate-to-advanced keratoconus and also to compare the results according to cone types, cone location, and severity of keratoconus. Materials and Methods. Sixty eyes of 40 participants were included in this retrospective study. Uncorrected visual acuity (UCVA), best-spectacle corrected visual acuity (BCVA), best-contact lens corrected visual acuity (BCLCVA), and comfort rating via visual analogue scales (VAS) were measured. Results. The mean age was 27.3 ± 8.6 years (range: 18 to 54). The mean logMAR UCVA, BCVA, and BCLCVA were 0.85 ± 0.38 (range: 0.30–1.30), 0.47 ± 0.27 (range: 0.10–1.30), and 0.16 ± 0.20 (range: 0–1.00). There were significant increases in visual acuities with contact lenses (p < .05). BCLCVA was significantly better in oval type than globus type (p = .022). UCVA and BCLCVA were significantly better in moderate keratoconus group (p = .015, p = .018). The mean line gain in Snellen was 3.6 ± 1.8 lines (range: 0–7 lines). The mean line gain was higher in central cone group than paracentral cone group and oval group than globus group (p = .014, p = .045). The mean VAS score was 8.14 ± 1.88 (range: 6–10). Conclusions. Toris K can improve visual acuity of patients with keratoconus. Toris K is successful even in the moderate and advanced form of the disease. PMID:27144012

  7. Studies of dynamic contact of ceramics and alloys for advanced heat engines. Final report

    Energy Technology Data Exchange (ETDEWEB)

    Gaydos, P.A.; Dufrane, K.F. [Battelle, Columbus, OH (United States)

    1993-06-01

    Advanced materials and coatings for low heat rejection engines have been investigated for almost a decade. Much of the work has concentrated on the critical wear interface between the piston ring and cylinder liner. Simplified bench tests have identified families of coatings with high temperature wear performance that could meet or exceed that of conventional engine materials at today`s operating temperatures. More recently, engine manufacturers have begun to optimize material combinations and manufacturing processes so that the materials not only have promising friction and wear performance but are practical replacements for current materials from a materials and manufacturing cost standpoint. In this study, the advanced materials supplied by major diesel engine manufacturers were evaluated in an experimental apparatus that simulates many of the in-cylinder conditions of a low heat rejection diesel engine. Results include ring wear factors and average dynamic friction coefficients measured at intervals during the test. These results are compared with other advanced materials tested in the past as well as the baseline wear of current engines. Both fabricated specimens and sections of actual ring and cylinder liners were used in the testing. Observations and relative friction and wear performance of the individual materials are provided.

  8. Advance Care Planning in Nursing Homes: Correlates of Capacity and Possession of Advance Directives

    Science.gov (United States)

    Allen, Rebecca S.; DeLaine, Shermetra R.; Chaplin, William F.; Marson, Daniel C.; Bourgeois, Michelle S.; Dijkstra, Katinka; Burgio, Louis D.

    2003-01-01

    Purpose: The identification of nursing home residents who can continue to participate in advance care planning about end-of-life care is a critical clinical and bioethical issue. This study uses high quality observational research to identify correlates of advance care planning in nursing homes, including objective measurement of capacity. Design…

  9. Recent Advances and Future Directions for Quality Engineering

    DEFF Research Database (Denmark)

    Vining, Geoff; Kulahci, Murat; Pedersen, Søren

    2015-01-01

    The origins of quality engineering are in manufacturing, where quality engineers apply basic statistical methodologies to improve the quality and productivity of products and processes. In the past decade, people have discovered that these methodologies are effective for improving almost any type...... of system or process, such as financial, health care, and supply chains. This paper begins with a review of key advances and trends within quality engineering over the past decade. The second part uses the first part as a foundation to outline new application areas for the field. It also discusses...

  10. Human lung tissue macrophages, but not alveolar macrophages, express matrix metalloproteinases after direct contact with activated T lymphocytes.

    Science.gov (United States)

    Ferrari-Lacraz, S; Nicod, L P; Chicheportiche, R; Welgus, H G; Dayer, J M

    2001-04-01

    Human alveolar macrophages (AM) and lung tissue macrophages (LTM) have a distinct localization in the cellular environment. We studied their response to direct contact with activated T lymphocytes in terms of the production of interstitial collagenase (MMP-1), 92-kD gelatinase (MMP-9), and of TIMP-1, one of the counter-regulatory tissue inhibitors of metalloproteinases. Either AM obtained by bronchoalveolar lavage or LTM obtained by mincing and digestion of lung tissue were exposed for 48 h to plasma membranes of T lymphocytes previously activated with phorbol myristate acetate and phytohemagglutinin for 24 h. Membranes of activated T cells strongly induced the production of MMP-1, MMP-9, and TIMP-1 exclusively in LTM but not in AM, whereas membranes from unstimulated T cells failed to induce the release of MMPs. Both populations of mononuclear phagocytes spontaneously released only small amounts of MMPs and TIMP-1. Similar results were obtained when MMP and TIMP-1 expression was analyzed at pretranslational and biosynthetic levels, respectively. Blockade experiments with cytokine antagonists revealed the involvement of T-cell membrane-associated interleukin-1 and tumor necrosis factor-alpha in MMP production by LTM upon contact with T cells. These data suggest that the ability of lung macrophages to produce MMPs after direct contact with activated T cells is related to the difference in phenotype of mononuclear phagocytes and cell localization. In addition, these observations indicate that cell-cell contact represents an important biological mechanism in potentiating the inflammatory response of mononuclear phagocytes in the lungs. PMID:11306438

  11. The Degradation Interface of Magnesium Based Alloys in Direct Contact with Human Primary Osteoblast Cells

    OpenAIRE

    Ahmad Agha, Nezha; Willumeit-Römer, Regine; Laipple, Daniel; Luthringer, Bérengère; Feyerabend, Frank

    2016-01-01

    Magnesium alloys have been identified as a new generation material of orthopaedic implants. In vitro setups mimicking physiological conditions are promising for material / degradation analysis prior to in vivo studies however the direct influence of cell on the degradation mechanism has never been investigated. For the first time, the direct, active, influence of human primary osteoblasts on magnesium-based materials (pure magnesium, Mg-2Ag and Mg-10Gd alloys) is studied for up to 14 days. Se...

  12. Advanced cellular ceramics processed using direct foaming methods

    OpenAIRE

    Guzi De Moraes, Elisangela

    2015-01-01

    The research work presented in this thesis concerns the development of silicon nitride based ceramics with a cellular structure and containing designed interconnected porosity (> 80 vol%) and cell size distribution (10 up to 800 μm) by direct foaming processing routes. Concentrated emulsions (O/W oil-in-water) stabilized by surfactants and gelcasting using environmentally friendly biopolymers as gelling agents, were developed as intermediates in the production of highly porous inorganic mater...

  13. Importance of the Direct Contact of Amorphous Solid Particles with the Surface of Monolayers for the Transepithelial Permeation of Curcumin.

    Science.gov (United States)

    Kimura, Shunsuke; Kasatani, Sachiha; Tanaka, Megumi; Araki, Kaeko; Enomura, Masakazu; Moriyama, Kei; Inoue, Daisuke; Furubayashi, Tomoyuki; Tanaka, Akiko; Kusamori, Kosuke; Katsumi, Hidemasa; Sakane, Toshiyasu; Yamamoto, Akira

    2016-02-01

    The amorphization has been generally known to improve the absorption and permeation of poorly water-soluble drugs through the enhancement of the solubility. The present study focused on the direct contact of amorphous solid particles with the surface of the membrane using curcumin as a model for water-insoluble drugs. Amorphous nanoparticles of curcumin (ANC) were prepared with antisolvent crystallization method using a microreactor. The solubility of curcumin from ANC was two orders of magnitude higher than that of crystalline curcumin (CC). However, the permeation of curcumin from the saturated solution of ANC was negligible. The transepithelial permeation of curcumin from ANC suspension was significantly increased as compared to CC suspension, while the permeation was unlikely correlated with the solubility, and the increase in the permeation was dependent on the total concentration of curcumin in ANC suspension. The absorptive transport of curcumin (from apical to basal, A to B) from ANC suspension was much higher than the secretory transport (from basal to apical, B to A). In vitro transport of curcumin through air-interface monolayers is large from ANC but negligible from CC particles. These findings suggest that the direct contact of ANC with the absorptive membrane can play an important role in the transport of curcumin from ANC suspension. The results of the study suggest that amorphous particles may be directly involved in the transepithlial permeation of curcumin. PMID:26656401

  14. The Degradation Interface of Magnesium Based Alloys in Direct Contact with Human Primary Osteoblast Cells.

    Directory of Open Access Journals (Sweden)

    Nezha Ahmad Agha

    Full Text Available Magnesium alloys have been identified as a new generation material of orthopaedic implants. In vitro setups mimicking physiological conditions are promising for material / degradation analysis prior to in vivo studies however the direct influence of cell on the degradation mechanism has never been investigated. For the first time, the direct, active, influence of human primary osteoblasts on magnesium-based materials (pure magnesium, Mg-2Ag and Mg-10Gd alloys is studied for up to 14 days. Several parameters such as composition of the degradation interface (directly beneath the cells are analysed with a scanning electron microscope equipped with energy dispersive X-ray and focused ion beam. Furthermore, influence of the materials on cell metabolism is examined via different parameters like active mineralisation process. The results are highlighting the influences of the selected alloying element on the initial cells metabolic activity.

  15. Advanced Low Conductivity Thermal Barrier Coatings: Performance and Future Directions

    Science.gov (United States)

    Zhu, Dongming; Miller, Robert A.

    2008-01-01

    Thermal barrier coatings will be more aggressively designed to protect gas turbine engine hot-section components in order to meet future engine higher fuel efficiency and lower emission goals. In this presentation, thermal barrier coating development considerations and performance will be emphasized. Advanced thermal barrier coatings have been developed using a multi-component defect clustering approach, and shown to have improved thermal stability and lower conductivity. The coating systems have been demonstrated for high temperature combustor applications. For thermal barrier coatings designed for turbine airfoil applications, further improved erosion and impact resistance are crucial for engine performance and durability. Erosion resistant thermal barrier coatings are being developed, with a current emphasis on the toughness improvements using a combined rare earth- and transition metal-oxide doping approach. The performance of the toughened thermal barrier coatings has been evaluated in burner rig and laser heat-flux rig simulated engine erosion and thermal gradient environments. The results have shown that the coating composition optimizations can effectively improve the erosion and impact resistance of the coating systems, while maintaining low thermal conductivity and cyclic durability. The erosion, impact and high heat-flux damage mechanisms of the thermal barrier coatings will also be described.

  16. Advancements and future directions in enzyme technology for biomass conversion.

    Science.gov (United States)

    Zhang, Zisheng; Donaldson, Adam A; Ma, Xiaoxun

    2012-01-01

    Enzymatic hydrolysis of pre-treated lignocellulosic biomass is an ideal alternative to acid hydrolysis for bio-ethanol production, limited primarily by pre-treatment requirements and economic considerations arising from enzyme production costs and specific activities. The quest for cheaper and better enzymes has prompted years of bio-prospecting, strain optimization through genetic engineering, enzyme characterization for simple and complex lignocellulosic feedstock, and the development of pre-treatment strategies to mitigate inhibitory effects. The recent shift to systematic characterizations of de novo mixtures of purified proteins is a promising indicator of maturation within this field of study, facilitating progression towards feedstock assay-based rapid enzyme mixture optimization. It is imperative that international standards be developed to enable meaningful comparisons between these studies and the construction of a database of enzymatic activities and kinetics, aspects of which are explored here-in. Complementary efforts to improve the economic viability of enzymatic hydrolysis through process integration and reactor design are also considered, where membrane-confinement shows significant promise despite the associated technological challenges. Significant advancements in enzyme technology towards the economic conversion of lignocellulosic biomass should be expected within the next few years as systematic research in enzyme activities conforms to that of traditional reaction engineering. PMID:22306162

  17. Advances and directions of ion nitriding/carburizing

    Science.gov (United States)

    Spalvins, Talivaldis

    1989-01-01

    Ion nitriding and carburizing are plasma activated thermodynamic processes for the production of case hardened surface layers not only for ferrous materials, but also for an increasing number of nonferrous metals. When the treatment variables are properly controlled, the use of nitrogenous or carbonaceous glow discharge medium offers great flexibility in tailoring surface/near-surface properties independently of the bulk properties. The ion nitriding process has reached a high level of maturity and has gained wide industrial acceptance, while the more recently introduced ion carburizing process is rapidly gaining industrial acceptance. The current status of plasma mass transfer mechanisms into the surface regarding the formation of compound and diffusion layers in ion nitriding and carbon build-up ion carburizing is reviewed. In addition, the recent developments in design and construction of advanced equipment for obtaining optimized and controlled case/core properties is summarized. Also, new developments and trends such as duplex plasma treatments and alternatives to dc diode nitriding are highlighted.

  18. Ceramic thermal wind sensor based on advanced direct chip attaching package

    International Nuclear Information System (INIS)

    An advanced direct chip attaching packaged two-dimensional ceramic thermal wind sensor is studied. The thermal wind sensor chip is fabricated by metal lift-off processes on the ceramic substrate. An advanced direct chip attaching (DCA) packaging is adopted and this new packaged method simplifies the processes of packaging further. Simulations of the advanced DCA packaged sensor based on computational fluid dynamics (CFD) model show the sensor can detect wind speed and direction effectively. The wind tunnel testing results show the advanced DCA packaged sensor can detect the wind direction from 0° to 360° and wind speed from 0 to 20 m/s with the error less than 0.5 m/s. The nonlinear fitting based least square method in Matlab is used to analyze the performance of the sensor. (semiconductor devices)

  19. Status and future directions for advanced accelerator research - conventional and non-conventional collider concepts

    International Nuclear Information System (INIS)

    The relationship between advanced accelerator research and future directions for particle physics is discussed. Comments are made about accelerator research trends in hadron colliders, muon colliders, and e+3- linear colliders

  20. Light-addressable amperometric electrodes for enzyme sensors based on direct quantum dot-electrode contacts

    Science.gov (United States)

    Riedel, M.; Göbel, G.; Parak, W. J.; Lisdat, F.

    2014-03-01

    Quantum dots allow the generation of charge carriers upon illumination. When these particles are attached to an electrode a photocurrent can be generated. This allows their use as a light-switchable layer on the surface. The QDs can not only exchange electronics with the electrode, but can also interact with donor or acceptor compounds in solution providing access to the construction of signal chains starting from an analytic molecule. The magnitude and the direction of the photocurrent depend on several factors such as electrode polarization, solution pH and composition. These defined dependencies have been evaluated with respect to the combination of QD-electrodes with enzyme reactions for sensorial purpose. CdSe/ZnS-QD-modified electrodes can be used to follow enzymatic reactions in solution based on the oxygen sensitivity. In order to develop a photoelectrochemical biosensor, e.g. glucose oxidase is immobilized on the CdSe/ZnS-electrode. One immobilization strategy applies the layer-by-layer-technique of GOD and a polyelectrolyte. Photocurrent measurements of such a sensor show a clear concentration dependent behavior. The principle of combing QD oxidase. The sensitivity of quantum dot electrodes can be influenced by additional nanoparticles, but also by multiple layers of the QDs. In another direction of research it can be influenced by additional nanoparticles, but also by multiple layers of the QDs. In another direction of research it can be demonstrated that direct electron transfer from excited quantum dots can be achieved with the redox protein cytochrome c. This allows the detection of the protein, but also interaction partners such as a enzymes or superoxide.

  1. Process Knowledge Summary Report for Advanced Test Reactor Complex Contact-Handled Transuranic Waste Drum TRA010029

    Energy Technology Data Exchange (ETDEWEB)

    B. R. Adams; R. P. Grant; P. R. Smith; J. L. Weisgerber

    2013-09-01

    This Process Knowledge Summary Report summarizes information collected to satisfy the transportation and waste acceptance requirements for the transfer of one drum containing contact-handled transuranic (TRU) actinide standards generated by the Idaho National Laboratory at the Advanced Test Reactor (ATR) Complex to the Advanced Mixed Waste Treatment Project (AMWTP) for storage and subsequent shipment to the Waste Isolation Pilot Plant for final disposal. The drum (i.e., Integrated Waste Tracking System Bar Code Number TRA010029) is currently stored at the Materials and Fuels Complex. The information collected includes documentation that addresses the requirements for AMWTP and applicable sections of their Resource Conservation and Recovery Act permits for receipt and disposal of this TRU waste generated from ATR. This Process Knowledge Summary Report includes information regarding, but not limited to, the generation process, the physical form, radiological characteristics, and chemical contaminants of the TRU waste, prohibited items, and packaging configuration. This report, along with the referenced supporting documents, will create a defensible and auditable record for this TRU waste originating from ATR.

  2. Potable water recovery from As, U, and F contaminated ground waters by direct contact membrane distillation process

    Energy Technology Data Exchange (ETDEWEB)

    Yarlagadda, Saketa; Gude, Veera Gnaneswar; Camacho, Lucy Mar; Pinappu, Saireddy [Chemical Engineering Department, New Mexico State University, Las Cruces, NM 88003 (United States); Deng, Shuguang, E-mail: sdeng@nmsu.edu [Chemical Engineering Department, New Mexico State University, Las Cruces, NM 88003 (United States)

    2011-09-15

    Highlights: {yields} Direct contact membrane distillation. {yields} 99% of arsenic, uranium and fluoride rejection. {yields} Potable water recovery. - Abstract: In this study, the feasibility of the direct contact membrane distillation (DCMD) process to recover arsenic, uranium and fluoride contaminated saline ground waters was investigated. Two types of membranes (polypropylene, PP; and polytetrafluoroethylene, PTFE) were tested to compare the permeate production rates and contaminant removal efficiencies. Several experiments were conducted to study the effect of salts, arsenic, fluoride and uranium concentrations (synthetic brackish water with salts: 1000-10,000 ppm; arsenic and uranium: 10-400 ppb; fluoride: 1-30 ppm) on the desalination efficiency. The effect of process variables such as feed flow rate, feed temperature and pore size was studied. The experimental results proved that the DCMD process is able to achieve over 99% rejection of the salts, arsenic, fluoride and uranium contaminants and produced a high quality permeate suitable for many beneficial uses. The ability to utilize the low grade heat sources makes the DCMD process a viable option to recover potable water from a variety of impaired ground waters.

  3. Potable water recovery from As, U, and F contaminated ground waters by direct contact membrane distillation process

    International Nuclear Information System (INIS)

    Highlights: → Direct contact membrane distillation. → 99% of arsenic, uranium and fluoride rejection. → Potable water recovery. - Abstract: In this study, the feasibility of the direct contact membrane distillation (DCMD) process to recover arsenic, uranium and fluoride contaminated saline ground waters was investigated. Two types of membranes (polypropylene, PP; and polytetrafluoroethylene, PTFE) were tested to compare the permeate production rates and contaminant removal efficiencies. Several experiments were conducted to study the effect of salts, arsenic, fluoride and uranium concentrations (synthetic brackish water with salts: 1000-10,000 ppm; arsenic and uranium: 10-400 ppb; fluoride: 1-30 ppm) on the desalination efficiency. The effect of process variables such as feed flow rate, feed temperature and pore size was studied. The experimental results proved that the DCMD process is able to achieve over 99% rejection of the salts, arsenic, fluoride and uranium contaminants and produced a high quality permeate suitable for many beneficial uses. The ability to utilize the low grade heat sources makes the DCMD process a viable option to recover potable water from a variety of impaired ground waters.

  4. Direct Human Contact with Siloxanes (Silicones) – Safety or Risk Part 1. Characteristics of Siloxanes (Silicones)

    Science.gov (United States)

    Mojsiewicz-Pieńkowska, Krystyna; Jamrógiewicz, Marzena; Szymkowska, Katarzyna; Krenczkowska, Dominika

    2016-01-01

    Siloxanes are commonly known as silicones. They belong to the organosilicon compounds and are exclusively obtained by synthesis. Their chemical structure determines a range of physicochemical properties which were recognized as unique. Due to the susceptibility to chemical modifications, ability to create short, long or complex polymer particles, siloxanes found an application in many areas of human life. Siloxanes differ in particle size, molecular weight, shape and chemical groups. As a result, this determines the different physico-chemical properties, that directly affect the safety or the risk of their use. The areas that can be a source of danger to human health will be commented in this paper. PMID:27303296

  5. Advances and Research Directions in Data-Warehousing Technology

    Directory of Open Access Journals (Sweden)

    Mukesh Mohania

    1999-11-01

    Full Text Available Information is one of the most valuable assets of an organisation and when used properly can assist in intelligent decision making that can significantly improve the functioning of an organisation. Data Warehousing is a recent technology that allows information to be easily and efficiently accessed for decision-making activities by collecting data from many operational, legacy and possibly heterogeneous data sources. On-Line Analytical Processing (OLAP tools are well-suited for complex data analysis, such as multi-dimensional data analysis, and to assist in decision support activities while data mining tools take the process one step further and actively search the data for patterns and hidden knowledge in the data held in the warehouse. Many organisations are building, or are planning to develop, a data warehouse for their operational and decision support needs. In this paper, we present an overview of data warehousing, multi-dimensional databases, OLAP and data mining technology and discuss the directions of current research in the area. We also discuss recent developments in data warehouse modelling, view selection and maintenance, indexing schemes, parallel query processing and data mining issues. A number of technical issues for exploratory research are presented and possible solutions are also discussed.

  6. The appearance of direct contacts between Auerbach's plexus and smooth muscle cells in the small intestine of the chicken during in ovo development.

    Science.gov (United States)

    Boros, A; Fekete, E

    1993-01-01

    Direct contacts between the neural cell bodies of Auerbach's ganglia and the longitudinal smooth muscle cells in the chicken small intestine were demonstrated by electron microscopy during the second half of embryonic development. The possible functional explanation of these contacts is discussed. PMID:8317199

  7. Modeling 3D conjugate heat and mass transfer for turbulent air drying of Chilean papaya in a direct contact dryer

    Science.gov (United States)

    Lemus-Mondaca, Roberto A.; Vega-Gálvez, Antonio; Zambra, Carlos E.; Moraga, Nelson O.

    2016-03-01

    A 3D model considering heat and mass transfer for food dehydration inside a direct contact dryer is studied. The k- ɛ model is used to describe turbulent air flow. The samples thermophysical properties as density, specific heat, and thermal conductivity are assumed to vary non-linearly with temperature. FVM, SIMPLE algorithm based on a FORTRAN code are used. Results unsteady velocity, temperature, moisture, kinetic energy and dissipation rate for the air flow are presented, whilst temperature and moisture values for the food also are presented. The validation procedure includes a comparison with experimental and numerical temperature and moisture content results obtained from experimental data, reaching a deviation 7-10 %. In addition, this turbulent k- ɛ model provided a better understanding of the transport phenomenon inside the dryer and sample.

  8. Advance Directives

    Science.gov (United States)

    ... Local Offices Volunteer Employment Become a Supplier Report Fraud or ... reserved. The American Cancer Society is a qualified 501(c)(3) tax-exempt organization. Cancer.org is provided courtesy of ...

  9. Bringing Advanced Directives and Symptom Assessment and Management to Community Oncology Practices

    OpenAIRE

    Lesperance, Mary; Shannon, Robert; Phyllis K. Pumphrey; Dunbar, Erin; Genther, Renee; Coleman, C. Lynn; Tabano, Margaret; Maurer, Jennifer; Vazquez, Adrienne; Capp, Elizabeth; McMillan, Jessica; Wilkerson, Katie; Robbins, Gerald; Phillips, Dorothy Green; Howick, Priscilla

    2013-01-01

    Palliative care services are not available in most outpatient oncology practices. A program training 11 mid-level providers from oncology practices on advanced directive discussions and supportive symptom assessment and management performed by palliative care specialists was completed. A follow-up session 9 months later identified barriers to implementation. Of the 11 mid-level providers, 8 participated in the follow-up session, and 9 of the 11 providers implemented advanced directive’s discu...

  10. Early experience with digital advance care planning and directives, a novel consumer-driven program

    OpenAIRE

    Fine, Robert L.; Yang, Zhiyong; Spivey, Christy; Boardman, Bonnie; Courtney, Maureen

    2016-01-01

    Barriers to traditional advance care planning (ACP) and advance directive (AD) creation have limited the promise of ACP/AD for individuals and families, the healthcare team, and society. Our objectives were to determine the results of a digital ACP/AD through which consumers create, store, locate, and retrieve their ACP/AD at no charge and with minimal physician involvement, and the ACP/AD can be integrated into the electronic health record. The authors chose 900 users of MyDirectives, a digi...

  11. Solid-contact potentiometric aptasensor based on aptamer functionalized carbon nanotubes for the direct determination of proteins.

    Science.gov (United States)

    Düzgün, Ali; Maroto, Alicia; Mairal, Teresa; O'Sullivan, Ciara; Rius, F Xavier

    2010-05-01

    A facile, solid-contact selective potentiometric aptasensor exploiting a network of single-walled carbon nanotubes (SWCNT) acting as a transducing element is described in this work. The molecular properties of the SWCNT surface have been modified by covalently linking aptamers as biorecognition elements to the carboxylic groups of the SWCNT walls. As a model system to demonstrate the generic application of the approach, a 15-mer thrombin aptamer interacts with thrombin and the affinity interaction gives rise to a direct potentiometric signal that can be easily recorded within 15 s. The dynamic linear range, with a sensitivity of 8.0 mV/log a(Thr) corresponds to the 10(-7)-10(-6) M range of thrombin concentrations, with a limit of detection of 80 nM. The aptasensor displays selectivity against elastase and bovine serum albumin and is easily regenerated by immersion in 2 M NaCl. The aptasensor demonstrates the capacity of direct detection of the recognition event avoiding the use of labels, mediators, or the addition of further reagents or analyte accumulation. PMID:20419254

  12. Detection of the position, direction and speed of sliding contact with a multi-layer compliant tactile sensor fabricated using direct-print technology

    International Nuclear Information System (INIS)

    A multi-layer resistance based compliant tactile sensor was fabricated using direct-print (DP) and soft molding processes. The sensor consists of two layers of embedded stretchable sensing elements sandwiched by three layers of a polyurethane rubber material. The sensing elements were created by the DP process using a photopolymer filled with multi-wall carbon nanotubes, which exhibit the property of piezoresistivity. The printed sensing elements were fully cured using ultraviolet light. The sensing elements within each layer of the sensor structure change in electrical resistance when external forces are applied. By processing the measured sensor signals, the fabricated sensor was able to detect the position of contact forces with a 3 mm spatial resolution, as well as their two-dimensional translation directions and speeds. Based on the results, it is concluded that the fabricated sensors are promising in robotic applications and the developed process and material can be a reliable and robust way to build highly stretchable tactile sensors. (paper)

  13. The pathogenesis of highly virulent African Swine Fever virus in domestic pigs exposed via intraoropharyngeal, intranasopharyngeal, and intramuscular inoculation, and by direct contact with infected pigs

    Science.gov (United States)

    In order to optimize novel systems for African Swine Fever Virus (ASFV) vaccine development, domestic pigs were challenged with the highly virulent ASFV-Malawi strain via intraoropharyngeal (IOP), intranasopharyngeal (INP), intramuscular (IM), and direct contact (DC) routes. Direct challenge doses ...

  14. Direct release of the allergen tulipalin A from Alstroemeria cut flowers: a possible source of airborne contact dermatitis?

    Science.gov (United States)

    Christensen, L P

    1999-12-01

    The allergen tulipalin A was collected by dynamic headspace technique from cut flowers of 2 Alstroemeria hybrids and quantified and identified by gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS). The amounts of tulipalin A released into the air were correlated with the tulipalin A and the total allergen content (tulipalin A and tuliposides) in the plant tissue, respectively. Tulipalin A was released primarily from the wounded areas, i.e. the stems, although small amounts were also emitted from the undamaged flowers in one of the hybrids. The tulipalin A concentrations in the stems of the Alstroemeria hybrids investigated were 0.06% and 0.13% of fresh weight, respectively, and the amounts directly released from the cut flowers were 0.4 and 2.2 microg (cut flower)(-1) h(-1), respectively. The content of tulipalin A exceeded that of tuliposides in leaves and flowers of both hybrids, whereas the content of tulipalin A in stems (in % fresh weight) was slightly lower than the content of tuliposides. The possibility that airborne tulipalin A from Alstroemeria could be a source of airborne contact dermatitis is discussed. PMID:10617212

  15. The antibacterial activity of sodium hypochlorite and chlorhexidine against Enterococcus faecalis: A review on agar diffusion and direct contact methods

    Directory of Open Access Journals (Sweden)

    Norhayati Luddin

    2013-01-01

    Full Text Available Complete debridement and disinfection of the root canal system are fundamental requirements for successful endodontic treatment. Despite the morphological challenges of the internal root anatomy, root canal irrigants play an important role in the optimization of the root canal preparation, which is essentially a chemo-mechanical procedure. Enterococcus faecalis is one of the most resistant microorganisms that dominants the microbial ecosystem of persistent periradicular lesions in retreatment cases. For that reason, many in vitro and in vivo studies evaluated and compared the antibacterial activity of sodium hypochlorite and chlorhexidine at varying concentrations using different experimental models against this microorganism. However, many controversies with regard to the ideal irrigant and concentration do in fact exist. Hence, this review aims to discuss the antibacterial activity of these two main root canal irrigants against Enterococcus faecalis using the agar diffusion and direct contact methods and the possible modulating factors responsible for inconsistent findings among different studies. In addition, the disinfection potential of both chemical agents on gutta percha and Resilon cones are also discussed. The source of this review was conducted through an electronic literature search using PubMed database from December 1997 until December 2011, which analyze the related laboratory investigations of both irrigants, published in major endodontic journals.

  16. Organic rankine cycle coupled to a solar pond by direct-contact heat exchange - selection of a working fluid

    Science.gov (United States)

    Wright, J. D.

    1982-06-01

    Heat from a solar pond may be used to drive an organic Rankine cycle and produce electricity. Due to the inherent low efficiency of low temperature cycles, large amounts of heat must be transferred, and heat exchangers may account for up to 50% of the plant cost. Use of a direct contact boiler, in which the organic fluid is bubbled through a stream of pond brine, may reduce the plant cost by about 25%. The choice of a working fluid affects plant efficiency, turbine cost, and the loss rate of the organic fluid. Low vapor pressure fluids maximize cycle efficiency by minimizing pumping requirements, but require a larger turbine. Efficiency affects the size and cost of the entire plant and low pressure fluids are preferred. The saturated and halogenated hydrocarbons were evaluated for use as working fluids. It is found that the working fluid is best suited to this application, because of high efficiency, low solubility in the pond, and a reasonable turbine cost.

  17. Direct-contact condensation in the presence of noncondensables over free-falling films with intermittent liquid feed

    International Nuclear Information System (INIS)

    An intermittent (periodic) liquid flow rate is examined as a means to enhance local condensation rates in a vertical column where quasi-stagnant vapor-gas mixtures come in direct contact with falling wavy liquid layers. The gas mixture being effectively stagnant is responsible for the major resistance to heat transfer due to its relatively large concentration of noncondensables. Flow intermittency is found to improve heat transfer rates by as much as an order of magnitude. The local condensation heat transfer coefficients depend greatly on both liquid flow mode and liquid flow rate. For the range of frequencies encountered here, the flow cycling frequency seems to have only a minor effect on the transport process, whereas the asymmetry in the intermittency (flow/pause time periods) appears to be more significant. Statistical analysis of the measured local fluctuations of film thickness reveals that condensation is responsible only for slight modifications of the isothermal liquid surface morphology. There is also evidence that the interfacial transport process is aided by increased liquid wave velocities. (author)

  18. Heavy-Metal Aerosol Transport in a Lead-Bismuth-Cooled Fast Reactor with In-Vessel Direct-Contact Steam Generation

    International Nuclear Information System (INIS)

    The choice of lead or lead alloys (Pb-Bi) as the coolant of a fast reactor offers the potential for enhanced safety and reliability due to their benign physical and chemical characteristics. In an effort to assess this class of coolants in advanced nuclear systems of the next generation, an innovative fast reactor concept that eliminates the need for steam generators and main coolant pumps and thus offers capital and operating cost reduction was explored. The working steam is generated by direct-contact vaporization of water by liquid metal in the chimney above the core and is then sent directly to the turbine. The presence of a lighter fluid in the chimney substantially enhances the natural circulation of the Pb-Bi within the reactor pool. A key technical issue of this reactor concept is the consequences of Pb-Bi aerosol generation within the vessel, its transport within the power cycle components and impact on the design and operation of the turbine.Generation, transport, and deposition of Pb-Bi aerosols were modeled. It was found that the utilization of a suitable chevron steam separator design reduces the heavy-liquid metal transported to the steam lines by about three orders of magnitude. Nevertheless, the residual Pb-Bi (∼0.003 kg/s) is predicted to be sufficient to cause embrittlement of the turbine blades if conventional materials are used and the plant is to operate for 40 yr. Four solutions to this problem were assessed and found potentially viable from a technical standpoint: blade coating, employment of alternative materials, electrostatic precipitation, and oxidation of the Pb-Bi droplets

  19. End-of-life communication in Korean older adults: With focus on advance care planning and advance directives.

    Science.gov (United States)

    Shin, Dong Wook; Lee, Ji Eun; Cho, BeLong; Yoo, Sang Ho; Kim, SangYun; Yoo, Jun-Hyun

    2016-04-01

    The present article aimed to provide a comprehensive review of current status of end-of-life (EOL) care and sociocultural considerations in Korea, with focus on the EOL communication and use of advance directives (AD) in elderly Koreans. Through literature review, we discuss the current status of EOL care and sociocultural considerations in Korea, and provide a look-ahead. In Korea, patients often receive life-sustaining treatment until the very end of life. Advance care planning is rare, and most do-not-resuscitate decisions are made between the family and physician at the very end of patient's life. Koreans, influenced mainly by Confucian tradition, prefer a natural death and discontinuation of life-sustaining treatment. Although Koreans generally believe that death is natural and unavoidable, they tend not to think about or discuss death, and regard preparation for death as unnecessary. As a result, AD are completed by just 4.7% of the general adult population. This situation can be explained by several sociocultural characteristics including opting for natural death, wish not to burden others, preference for family involvement and trust in doctor, avoidance of talking about death, and filial piety. Patients often receive life-sustaining treatment until the very EOL, advance care planning and the use of AD is not common in Korea. This was related to unique sociocultural characteristics of Korea. A more active role of physicians, development of a more deliberate EOL discussion process, development of culturally appropriate AD and promotion of advance care planning might be required to provide good EOL care in Korea. Geriatr Gerontol Int 2016; 16: 407-415. PMID:26459613

  20. Effects of metal/Ge contact and surface passivation on direct band gap light emission and detection for asymmetric metal/Ge/metal diodes

    Science.gov (United States)

    Maekura, Takayuki; Yamamoto, Keisuke; Nakashima, Hiroshi; Wang, Dong

    2016-04-01

    Direct band gap electroluminescence (EL) and light detection were studied at room temperature for n-type bulk germanium (Ge) by using fin-type asymmetric lateral metal/Ge/metal diodes. HfGe/Ge and PtGe/Ge contacts were used for injecting holes. Electron cyclotron resonance plasma oxidation and physical vapor deposition bilayer passivation (BLP) methods were employed for passivating the surface of the active region. A high EL intensity and a low dark current intensity were observed for the sample with PtGe/Ge contact and BLP, owing to the small/large barrier height of holes/electrons for PtGe/Ge contact, respectively, and the low density of interface states for the active region with BLP. The local-heating-induced redshift of the EL peak for the sample with PtGe/Ge contact is smaller than that for the sample with HfGe/Ge contact, owing to the lower parasitic resistance of PtGe/Ge contact. The diode with PtGe/Ge contact and BLP shows an on/off ratio of ∼104 and a responsivity of 0.70 A/W, corresponding to an external quantum efficiency of 56.0% under a wavelength of 1.55 µm.

  1. CFD based approach for modeling direct contact condensation heat transfer in two-phase turbulent stratified flows

    International Nuclear Information System (INIS)

    This paper describes a CFD based strategy for the modeling of stratified two-phase flows with heat and mass transfer across a moving steam-water interface due to direct contact condensation. Such flows have been of major importance for example in connection with the analysis of nuclear reactor safety systems, in particular during two-phase Pressurized Thermal Shock (PTS) scenarios. The approach is based on the two-fluid phase-average model. The interfacial friction was modeled by using an Algebraic Interfacial Area Density (AIAD) framework where the drag coefficient is a function of the local flow characteristics. To show the impact of the modeling of interfacial friction the simulation with the AIAD model was compared with a simulation where a constant drag coefficient of 0.44 was used in the whole domain. For the modeling of interfacial heat and mass transfer two correlations for the water heat transfer coefficient based on the penetration theory were utilized. The CFD simulations were validated against a steady-state TOPFLOW-PTS steam/water experiment. In the experiment, very detailed temperature measurements were conducted using special thermocouple lances and infrared thermography. Total condensation rate was determined indirectly by using three different methods. The simulations have shown that the results obtained with the AIAD model are considerably closer to the experimental observations than the results obtained with the constant drag coefficient. The condensation models used in the current study predict quite different total condensation rates. That caused significant differences in the temperature field. The simulations of the TOPFLOW-PTS steam/water experiment with condensation have shown that the proposed CFD modeling approach can be successfully applied for the prediction of temperature field and condensation rate during two-phase Pressurized Thermal Shock scenarios. However, the modeling of turbulent interfacial heat transfer should be improved

  2. Experimental study on dynamic pressure pulse in direct contact condation of steam jets discharging into subcooled water

    International Nuclear Information System (INIS)

    The dynamic pressure resulting from direct contact condensation of steam jets discharging into a subcooled water has been measured as a function of steam mass flux and subcooled water temperature. Steam is discharged in a horizontal direction through four different size nozzles placed in the middle of a quenching tank, which contains water at various temperatures. Four different horizontal nozzles with an internal diameter in the range of 5∼20mm were used under the various test conditions of the steam mass flux in the wide range of 24∼1190 kg/m2-s and the pool water temperature in the range of 20∼95 .deg. C. It is observed from the test results that the amplitude of dynamic pressure pulse at condensation oscillation condition becomes greater than that at a stable condensation condition of the same pool temperature . The dynamic pressure tends to increase with pool temperature at the beginning. The amplitude reached a peak at a pool temperature around 60 ∼80.deg. C depending on nozzle size and steam mass flux and then the amplitude decrased rapidly before the pool water reached saturation temperature. The amplitude of the dynamic pressure pulse at the unstable condition reached it peak at the condition of pool temperature 60.deg. C, but the amplitude peack at the stable condition was found at around 80.deg. C. The chugging phenomena have been observed at low steam mass flux (below 80 kg/m2-s). The condensation regime map has been constructed by acoustic/visual observations and dynamic pressure behaviors. The condensation regime map consists of six regimes such as chugging, transient chugging, condensation oscillation, stable condensation, bubble condensation oscillation, and interfacial oscillation condensation. As the pool temperature increases above 90 .deg. C the steam discharging into a subcooled water does not condense completely in the pool and part of it escapes through the free surface of water. The transition from condensation socillations to stable

  3. [Respect for autonomy of "incompetent" patients?--the ethical problem of advanced directives].

    Science.gov (United States)

    Rehbock, Theda

    2005-12-01

    In addressing the ethical and legal problems of advanced directives, the article discusses whether respect for the autonomy of the so-called "incompetent" patients is possible and morally required. Starting with a critique of how modern medicine threatens patient autonomy and care (2.), the author goes on to highlight the mutual interdependence between respect for autonomy and patient care as two moral requirements arising from respect for human dignity (3.). Finally; the article elucidates the practical consequences as they relate to a treatment approach for each patient that is simultaneously caring and respectful of their autonomy, commenting on the ramifications for a sensitive and conscientious approach to advanced medical directives and for the special -role of nursing in this context. PMID:16398303

  4. Direct contact transmission of three different foot-and-mouth disease virus strains in swine demonstrates important strain-specific differences

    Science.gov (United States)

    A novel direct contact transmission model for the study of foot-and-mouth disease virus (FMDV) infection of swine was utilized to investigate transmission characteristics of three FMDV strains belonging to serotypes A, O and Asia1. Each strain demonstrated distinct transmission characteristics and r...

  5. Perspectives on advance directives in Japanese society: A population-based questionnaire survey

    OpenAIRE

    Slingsby Brian; Akabayashi Akira; Kai Ichiro

    2003-01-01

    Abstract Background In Japan, discussion concerning advance directives (ADs) has been on the rise during the past decade. ADs are one method proposed to facilitate the process of communication among patients, families and health care providers regarding the plan of care of a patient who is no longer capable of communicating. In this paper, we report the results of the first in-depth survey on the general population concerning the preferences and use of ADs in Japan. Method A self-administered...

  6. Default options in advance directives: study protocol for a randomised clinical trial

    OpenAIRE

    Gabler, Nicole B.; Cooney, Elizabeth; Small, Dylan S.; Troxel, Andrea B.; Arnold, Robert M.; White, Douglas B.; Angus, Derek C.; Loewenstein, George; Volpp, Kevin G; Bryce, Cindy L.; Halpern, Scott D.

    2016-01-01

    Introduction Although most seriously ill Americans wish to avoid burdensome and aggressive care at the end of life, such care is often provided unless patients or family members specifically request otherwise. Advance directives (ADs) were created to provide opportunities to set limits on aggressive care near life's end. This study tests the hypothesis that redesigning ADs such that comfort-oriented care is provided as the default, rather than requiring patients to actively choose it, will pr...

  7. A Korean perspective on developing a global policy for advance directives.

    Science.gov (United States)

    Kim, Soyoon; Hahm, Ki-Hyun; Park, Hyoung Wook; Kang, Hyun Hee; Sohn, Myongsei

    2010-03-01

    Despite the wide and daunting array of cross-cultural obstacles that the formulation of a global policy on advance directives will clearly pose, the need is equally evident. Specifically, the expansion of medical services driven by medical tourism, just to name one important example, makes this issue urgently relevant. While ensuring consistency across national borders, a global policy will have the additional and perhaps even more important effect of increasing the use of advance directives in clinical settings and enhancing their effectiveness within each country, regardless of where that country's state of the law currently stands. One cross-cultural issue that may represent a major obstacle in formulating, let alone applying, a global policy is whether patient autonomy as the underlying principle for the use of advance directives is a universal norm or a construct of western traditions that must be reconciled with alternative value systems that may place lesser significance on individual choice. A global policy, at a minimum, must emphasize respect for patient autonomy, provision of medical information, limits to the obligations for physicians, and portability. And though the development of a global policy will be no easy task, active engagement in close collaboration with the World Health Organization can make it possible. PMID:20136819

  8. Thermal gasification or direct combustion? Comparison of advanced cogeneration systems in the sugarcane industry

    International Nuclear Information System (INIS)

    We compare different cogeneration system scenarios for efficient energy production from bagasse fuel in an Indonesian sugar and ethanol factory. These scenarios include the use of condensing-extraction steam turbines, variable speed electric drives for process equipment, measures to reduce low pressure steam demand for process needs, and two advanced cogeneration systems. One advanced system includes an 80 bar high pressure direct combustion steam Rankine cycle (advanced SRC), while the other uses a biomass integrated gasifier combined cycle (BIGCC); both utilize fuel dryers. Using steady-state thermodynamic models, we estimate that the net electricity generation potentials of the BIGCC and advanced SRC systems are approximately seven and five times the potential of the existing factory, respectively. The maximum net electricity generation potentials for the respective systems are 170 kWh/tc (BIGCC) and 140 kWh/tc (advanced SRC). However, the BIGCC system needs a bagasse feed rate that is 50 percent higher than the advanced SRC system to satisfy the factory low pressure steam demand for sugar and ethanol processing, which may affect its ability to provide steam and electricity during the off-season. For the Indonesian sugar factory, the annual revenue potential of the BIGCC system is US$14 million per year, approximately 50 percent higher than that of the advanced SRC system (electricity sale rate: US$45/MsWh; carbon credit price: US$13.60). BIGCC technology is still in an early stage of development and there are no commercial systems in sugar factories, so an advanced SRC system may be a more suitable option in the near future. -- Highlights: ► We use steady state thermodynamic models to simulate a sugar-ethanol factory. ► We compare existing performance with five improved and advanced cogeneration system scenarios. ► High pressure steam Rankine cycle can significantly increase electricity generation. ► Biomass integrated gasification combined cycle can

  9. Nitroreductase gene-directed enzyme prodrug therapy: insights and advances toward clinical utility.

    Science.gov (United States)

    Williams, Elsie M; Little, Rory F; Mowday, Alexandra M; Rich, Michelle H; Chan-Hyams, Jasmine V E; Copp, Janine N; Smaill, Jeff B; Patterson, Adam V; Ackerley, David F

    2015-10-15

    This review examines the vast catalytic and therapeutic potential offered by type I (i.e. oxygen-insensitive) nitroreductase enzymes in partnership with nitroaromatic prodrugs, with particular focus on gene-directed enzyme prodrug therapy (GDEPT; a form of cancer gene therapy). Important first indications of this potential were demonstrated over 20 years ago, for the enzyme-prodrug pairing of Escherichia coli NfsB and CB1954 [5-(aziridin-1-yl)-2,4-dinitrobenzamide]. However, it has become apparent that both the enzyme and the prodrug in this prototypical pairing have limitations that have impeded their clinical progression. Recently, substantial advances have been made in the biodiscovery and engineering of superior nitroreductase variants, in particular development of elegant high-throughput screening capabilities to enable optimization of desirable activities via directed evolution. These advances in enzymology have been paralleled by advances in medicinal chemistry, leading to the development of second- and third-generation nitroaromatic prodrugs that offer substantial advantages over CB1954 for nitroreductase GDEPT, including greater dose-potency and enhanced ability of the activated metabolite(s) to exhibit a local bystander effect. In addition to forging substantial progress towards future clinical trials, this research is supporting other fields, most notably the development and improvement of targeted cellular ablation capabilities in small animal models, such as zebrafish, to enable cell-specific physiology or regeneration studies. PMID:26431849

  10. Consciousness in humans and non-human animals: recent advances and future directions

    Science.gov (United States)

    Boly, Melanie; Seth, Anil K.; Wilke, Melanie; Ingmundson, Paul; Baars, Bernard; Laureys, Steven; Edelman, David B.; Tsuchiya, Naotsugu

    2013-01-01

    This joint article reflects the authors' personal views regarding noteworthy advances in the neuroscience of consciousness in the last 10 years, and suggests what we feel may be promising future directions. It is based on a small conference at the Samoset Resort in Rockport, Maine, USA, in July of 2012, organized by the Mind Science Foundation of San Antonio, Texas. Here, we summarize recent advances in our understanding of subjectivity in humans and other animals, including empirical, applied, technical, and conceptual insights. These include the evidence for the importance of fronto-parietal connectivity and of “top-down” processes, both of which enable information to travel across distant cortical areas effectively, as well as numerous dissociations between consciousness and cognitive functions, such as attention, in humans. In addition, we describe the development of mental imagery paradigms, which made it possible to identify covert awareness in non-responsive subjects. Non-human animal consciousness research has also witnessed substantial advances on the specific role of cortical areas and higher order thalamus for consciousness, thanks to important technological enhancements. In addition, much progress has been made in the understanding of non-vertebrate cognition relevant to possible conscious states. Finally, major advances have been made in theories of consciousness, and also in their comparison with the available evidence. Along with reviewing these findings, each author suggests future avenues for research in their field of investigation. PMID:24198791

  11. Non-contact biopotential sensing

    OpenAIRE

    Chi, Yu Mike

    2011-01-01

    Ubiquitous physiological monitoring will be a key driving force in the upcoming wireless health revolution. Cardiac and brain signals in the form of ECG and EEG are two critical health indicators that directly benefit from long -term monitoring. Despite advancements in wireless technology and electronics miniaturization, however, the use of wireless home ECG/EEG monitoring is still limited by the inconvenience and discomfort of wet, contact electrodes. This research focuses on the development...

  12. Contact dermatitis

    Science.gov (United States)

    Dermatitis - contact; Allergic dermatitis; Dermatitis - allergic; Irritant contact dermatitis; Skin rash - contact dermatitis ... There are 2 types of contact dermatitis. Irritant dermatitis: This ... can be by contact with acids, alkaline materials such as soaps ...

  13. Guest Editorial Special Issue on Recent Advances and New Directions in Switched Control Systems

    Institute of Scientific and Technical Information of China (English)

    2006-01-01

    @@ As guest editors, it is our great honor to bring this special issue of the Journal of Control Theory and Applications devoted to Recent Advances and New Directions in Switched Control Systems. Recently, switched control systems have attracted much attention in the control systems community. Problems in this area are not only academically challenging for the inherent mathematical complexity, but also are derived or motivated from advanced applications in natural sciences, engineering, and social sciences. For survival, natural biological systems switch their survival strategies in accordance with environmental changes. For improved performance, switching has been extensively utilized/exploited in engineering systems such as automotive drive train control, electronic devices, control of power systems, etc.

  14. Wild orangutan males plan and communicate their travel direction one day in advance.

    Directory of Open Access Journals (Sweden)

    Carel P van Schaik

    Full Text Available The ability to plan for the future beyond immediate needs would be adaptive to many animal species, but is widely thought to be uniquely human. Although studies in captivity have shown that great apes are capable of planning for future needs, it is unknown whether and how they use this ability in the wild. Flanged male Sumatran orangutans (Pongo abelii emit long calls, which females use to maintain earshot associations with them. We tested whether long calls serve to communicate a male's ever-changing predominant travel direction to facilitate maintaining these associations. We found that the direction in which a flanged male emits his long calls predicts his subsequent travel direction for many hours, and that a new call indicates a change in his main travel direction. Long calls given at or near the night nest indicate travel direction better than random until late afternoon on the next day. These results show that male orangutans make their travel plans well in advance and announce them to conspecifics. We suggest that such a planning ability is likely to be adaptive for great apes, as well as in other taxa.

  15. Bagaza virus is pathogenic and transmitted by direct contact in experimentally infected partridges, but is not infectious in house sparrows and adult mice.

    Science.gov (United States)

    Llorente, Francisco; Pérez-Ramírez, Elisa; Fernández-Pinero, Jovita; Elizalde, Maia; Figuerola, Jordi; Soriguer, Ramón C; Jiménez-Clavero, Miguel Ángel

    2015-01-01

    Bagaza virus (BAGV) is a mosquito-borne flavivirus belonging to the Ntaya serocomplex. In 2010, a disease outbreak was reported in Cádiz (Southern Spain) affecting game birds (red-legged partridges and common pheasants). In this work, red-legged partridges were inoculated experimentally with infectious BAGV isolated from this outbreak in order to make a complete clinical and analytical assessment of the disease caused by the pathogen in this species. Viral load (by real-time RT-PCR) in blood, oral and cloacal swabs, and feathers, and neutralizing antibody titres (by VNT) were measured. In order to determine direct contact transmission, non-inoculated partridges were caged together with the inoculated ones. To assess infectiousness in other species, house sparrows and mice were also inoculated with the virus. All the inoculated partridges were clinically affected, and 30% of them died. All the infected individuals lost weight, with larger losses being recorded in females. Conversely, no mortality or disease symptoms were observed in the sparrows or mice. Remarkably, all the contact partridges acquired the infection by direct (non-vectored) transmission. This study confirms that the red-legged partridge is a susceptible host for BAGV infection, and that this pathogen is transmitted by direct contact. Long-lasting viral loads detected in calami of immature feathers demonstrate that feather sampling could be a useful strategy in active surveillance programs for early detection of BAGV. PMID:26338714

  16. Direct current electric potential in an anisotropic half-space with vertical contact containing a conductive 3D body

    Directory of Open Access Journals (Sweden)

    Li Ping

    2004-01-01

    Full Text Available Detailed studies of anomalous conductors in otherwise homogeneous media have been modelled. Vertical contacts form common geometries in galvanic studies when describing geological formations with different electrical conductivities on either side. However, previous studies of vertical discontinuities have been mainly concerned with isotropic environments. In this paper, we deal with the effect on the electric potentials, such as mise-à-la-masse anomalies, due to a conductor near a vertical contact between two anisotropic regions. We also demonstrate the interactive effects when the conductive body is placed across the vertical contact. This problem is normally very difficult to solve by the traditional numerical methods. The integral equations for the electric potential in anisotropic half-spaces are established. Green's function is obtained using the reflection and transmission image method in which five images are needed to fit the boundary conditions on the vertical interface and the air-earth surface. The effects of the anisotropy of the environments and the conductive body on the electric potential are illustrated with the aid of several numerical examples.

  17. The Recent Revolution in the Design and Manufacture of Cranial Implants: Modern Advancements and Future Directions.

    Science.gov (United States)

    Bonda, David J; Manjila, Sunil; Selman, Warren R; Dean, David

    2015-11-01

    Large format (i.e., >25 cm) cranioplasty is a challenging procedure not only from a cosmesis standpoint, but also in terms of ensuring that the patient's brain will be well-protected from direct trauma. Until recently, when a patient's own cranial flap was unavailable, these goals were unattainable. Recent advances in implant computer-aided design and 3-dimensional (3-D) printing are leveraging other advances in regenerative medicine. It is now possible to 3-D-print patient-specific implants from a variety of polymer, ceramic, or metal components. A skull template may be used to design the external shape of an implant that will become well integrated in the skull, while also providing beneficial distribution of mechanical force in the event of trauma. Furthermore, an internal pore geometry can be utilized to facilitate the seeding of banked allograft cells. Implants may be cultured in a bioreactor along with recombinant growth factors to produce implants coated with bone progenitor cells and extracellular matrix that appear to the body as a graft, albeit a tissue-engineered graft. The growth factors would be left behind in the bioreactor and the graft would resorb as new host bone invades the space and is remodeled into strong bone. As we describe in this review, such advancements will lead to optimal replacement of cranial defects that are both patient-specific and regenerative. PMID:26171578

  18. Trial examination of direct pebble fabrication for advanced tritium breeders by the emulsion method

    Energy Technology Data Exchange (ETDEWEB)

    Hoshino, Tsuyoshi, E-mail: hoshino.tsuyoshi@jaea.go.jp

    2014-10-15

    Highlights: • The integration of raw material preparation and granulation is proposed as a new direct pebble fabrication process. • The emulsion method granulates gel spheres of Li{sub 2}CO{sub 3} and TiO{sub 2} or SiO{sub 2}. • The gel spheres are calcined and sintered in air. • The crush load of the sintered Li{sub 2}TiO{sub 3} or Li{sub 4}SiO{sub 4} pebbles obtained is 37.2 or 59.3 N, respectively. - Abstract: Demonstration power plant reactors require advanced tritium breeders with high thermal stability. For the mass production of advanced tritium breeder pebbles, pebble fabrication by the emulsion method is a promising technique. To develop the most efficient pebble fabrication method, a new direct pebble fabrication process utilizing the emulsion method was implemented. A prior pebble fabrication process consisted of the preparation of raw materials followed by granulation. The new process integrates the preparation and granulation of raw materials. The slurry for the emulsion granulation of Li{sub 2}TiO{sub 3} or Li{sub 4}SiO{sub 4} as a tritium breeder consists of mixtures of Li{sub 2}CO{sub 3} and TiO{sub 2} or SiO{sub 2} at specific ratios. Subsequently, gel spheres of tritium breeders are fabricated by controlling the relative flow speeds of slurry and oil. The average diameter and crush load of the obtained sintered Li{sub 2}TiO{sub 3} or Li{sub 4}SiO{sub 4} pebbles were 1.0 or 1.5 mm and 37.2 or 59.3 N, respectively. The trial fabrication results suggest that the new process has the potential to increase the fabrication efficiency of advanced tritium breeder pebbles.

  19. Trial examination of direct pebble fabrication for advanced tritium breeders by the emulsion method

    International Nuclear Information System (INIS)

    Highlights: • The integration of raw material preparation and granulation is proposed as a new direct pebble fabrication process. • The emulsion method granulates gel spheres of Li2CO3 and TiO2 or SiO2. • The gel spheres are calcined and sintered in air. • The crush load of the sintered Li2TiO3 or Li4SiO4 pebbles obtained is 37.2 or 59.3 N, respectively. - Abstract: Demonstration power plant reactors require advanced tritium breeders with high thermal stability. For the mass production of advanced tritium breeder pebbles, pebble fabrication by the emulsion method is a promising technique. To develop the most efficient pebble fabrication method, a new direct pebble fabrication process utilizing the emulsion method was implemented. A prior pebble fabrication process consisted of the preparation of raw materials followed by granulation. The new process integrates the preparation and granulation of raw materials. The slurry for the emulsion granulation of Li2TiO3 or Li4SiO4 as a tritium breeder consists of mixtures of Li2CO3 and TiO2 or SiO2 at specific ratios. Subsequently, gel spheres of tritium breeders are fabricated by controlling the relative flow speeds of slurry and oil. The average diameter and crush load of the obtained sintered Li2TiO3 or Li4SiO4 pebbles were 1.0 or 1.5 mm and 37.2 or 59.3 N, respectively. The trial fabrication results suggest that the new process has the potential to increase the fabrication efficiency of advanced tritium breeder pebbles

  20. Photometric and H-alpha studies of two extreme mass-ratio short period contact binaries in the direction of open cluster Praesepe

    CERN Document Server

    Rukmini, J

    2016-01-01

    We present the high precession photometric studies in V band and spectroscopic studies centered around H-alpha line for two extreme mass-ratio short period contact binaries ASAS J082243+1927.0 (V1) and ASAS J085710+1856.8 (V2). The variables in study are in the direction of open cluster Praesepe. From the light curve analysis V1 was found to be a low mass-ratio over-contact binary of A-type, with a mass ratio q 0.121 and fill-out factor f 72%, and V2 was found to be a low mass contact binary of W-type, with a mass-ratio q 1.29 and fill-out factor f 11% (marginal contact). The study of H-alpha absorption line profile of both the variables shows variation in equivalent widths (EWs) with orbital phases. The mean EWs of the H-alpha line were obtained as 1.6+or-0.13 A and 1.18+or-0.12 A for V1 and V2 respectively. The variation of H-alpha absorption with respect to phase is explained to be due to chromospheric activity in V1, as evident from the O Connell effect and that due to chromospheric flares, winds or photo...

  1. A numerical approach for the direct computation of flows including fluid-solid interaction: Modeling contact angle, film rupture, and dewetting

    Science.gov (United States)

    Mahady, K.; Afkhami, S.; Kondic, L.

    2016-06-01

    In this paper, we present a computationally efficient method for including fluid-solid interactions into direct numerical simulations of the Navier-Stokes equations. This method is found to be as powerful as our earlier formulation [K. Mahady et al., "A volume of fluid method for simulating fluid/fluid interfaces in contact with solid boundaries," J. Comput. Phys. 294, 243 (2015)], while outperforming the earlier method in terms of computational efficiency. The performance and efficacy of the presented method are demonstrated by computing contact angles of droplets at equilibrium. Furthermore, we study the instability of films due to destabilizing fluid-solid interactions, and discuss the influence of contact angle and inertial effects on film breakup. In particular, direct simulation results show an increase in the final characteristic length scales when compared to the predictions of a linear stability analysis, suggesting significant influence of nonlinear effects. Our results also show that emerging length scales differ, depending on a number of physical dimensions considered.

  2. Contact lens sensors in ocular diagnostics.

    Science.gov (United States)

    Farandos, Nicholas M; Yetisen, Ali K; Monteiro, Michael J; Lowe, Christopher R; Yun, Seok Hyun

    2015-04-22

    Contact lenses as a minimally invasive platform for diagnostics and drug delivery have emerged in recent years. Contact lens sensors have been developed for analyzing the glucose composition of tears as a surrogate for blood glucose monitoring and for the diagnosis of glaucoma by measuring intraocular pressure. However, the eye offers a wider diagnostic potential as a sensing site and therefore contact lens sensors have the potential to improve the diagnosis and treatment of many diseases and conditions. With advances in polymer synthesis, electronics and micro/nanofabrication, contact lens sensors can be produced to quantify the concentrations of many biomolecules in ocular fluids. Non- or minimally invasive contact lens sensors can be used directly in a clinical or point-of-care setting to monitor a disease state continuously. This article reviews the state-of-the-art in contact lens sensor fabrication, their detection, wireless powering, and readout mechanisms, and integration with mobile devices and smartphones. High-volume manufacturing considerations of contact lenses are also covered and a case study of an intraocular pressure contact lens sensor is provided as an example of a successful product. This Review further analyzes the contact lens market and the FDA regulatory requirements for commercialization of contact lens sensors. PMID:25400274

  3. A Modified Time Advancement Algorithm for Optimizing Channel Flow Analysis in Direct Numerical Simulation Method

    Directory of Open Access Journals (Sweden)

    E. Rajabi

    2014-01-01

    Full Text Available In this research a direct numerical simulation (DNS of turbulent flow is performed in a geometrically standard case like plane channel flow. Pseudo spectral (PS method is used due to geometry specifications and very high accuracy achieved despite relatively few grid points. A variable time-stepping algorithm is proposed which may reduce requirement of computational cost in simulation of such wall-bounded flow. Channel flow analysis is performed with both constant and varied time-step for 128 × 65×128 grid points. The time advancement is carried out by implicit third-order backward differentiation scheme for linear terms and explicit forward Euler for nonlinear convection term. PS method is used in Cartesian coordinates with Chebychev polynomial expansion in normal direction for one non-periodic boundary condition. Also Fourier series is employed in stream-wise and span-wise directions for two periodic boundary conditions. The friction Reynolds number is about Reτ=175 based on a friction velocity and channel half width. Standard common rotational form was chosen for discritization of nonlinear convective term of Navier-Stocks equation. The comparison is made between turbulent quantities such as the turbulent statistics, Reynolds stress, wall shear velocity, standard deviation of (u and total normalized energy of instantaneous velocities in both time-discretization methods. The results show that if final decision rests on economics, the proposed variable time-stepping algorithm will be proper choice which satisfies the accuracy and reduces the computational cost.

  4. Preparation and evaluation of the cytotoxic nature of TiO2 nanoparticles by direct contact method

    OpenAIRE

    Vijayalakshmi, U.

    2015-01-01

    M Chellappa,1 U Anjaneyulu,1 Geetha Manivasagam,2 U Vijayalakshmi1 1School of Advanced Sciences, Materials Chemistry Division, 2Centre for Biomaterials Science and Technology, School of Mechanical and Building Sciences, VIT University, Vellore, Tamil Nadu, India Abstract: The purpose of this study is to prepare and evaluate the effect of synthesized titanium dioxide (TiO2) nanoparticles for their biocompatibility on physiological body fluids and the effect of cell toxicity to produ...

  5. Preparation and evaluation of the cytotoxic nature of TiO2 nanoparticles by direct contact method

    OpenAIRE

    Chellappa M; Anjaneyulu U; Manivasagam G; Vijayalakshmi U

    2015-01-01

    M Chellappa,1 U Anjaneyulu,1 Geetha Manivasagam,2 U Vijayalakshmi1 1School of Advanced Sciences, Materials Chemistry Division, 2Centre for Biomaterials Science and Technology, School of Mechanical and Building Sciences, VIT University, Vellore, Tamil Nadu, India Abstract: The purpose of this study is to prepare and evaluate the effect of synthesized titanium dioxide (TiO2) nanoparticles for their biocompatibility on physiological body fluids and the effect of cell toxicity to produce o...

  6. Advance Directives in Some Western European Countries: A Legal and Ethical Comparison between Spain, France, England, and Germany.

    Science.gov (United States)

    Veshi, Denard; Neitzke, Gerald

    2015-09-01

    We have studied national laws on advance directives in various Western European countries: Romance-speaking countries (Italy, France, Portugal, and Spain), English-speaking countries (Ireland and the United Kingdom), and German-speaking countries (Austria, Germany, and Switzerland). We distinguish two potentially complementary types of advance medical declaration: the 'living will' and the nomination of a legal proxy. After examining the similarities and differences between countries, we analyse in detail the legislation of four countries (Spain, France, England, and Germany), since the other countries in this survey have similar legal principles and/or a similar political approach. In conclusion, we note that in all the countries examined, advance directives have been seen as an instrument to enable the patient's right to self-determination. Notwithstanding, in Romance-speaking countries, the involvement of physicians in the end-of-life process and risks arising from the execution of advance directives were also considered. PMID:26427271

  7. Functional connectivity measures as schizophrenia intermediate phenotypes: advances, limitations, and future directions.

    Science.gov (United States)

    Cao, Hengyi; Dixson, Luanna; Meyer-Lindenberg, Andreas; Tost, Heike

    2016-02-01

    The search for quantifiable biological mediators of genetic risk or 'intermediate phenotypes' is an essential strategy in psychiatric neuroscience and a useful tool for exploring the complex relationships between genes, neural circuits and behaviors. In recent years, the examination of connectivity-based intermediate phenotypes has gained increasing popularity in the study of schizophrenia, a brain disorder that manifests in early adulthood and disturbs a wide range of neural network functions. To date, several potential connectivity phenotypes have been identified that link neuroimaging measures of neural circuit interaction to genetic susceptibility for schizophrenia. This paper briefly reviews recent advances, current limitations and future directions in the search for functional connectivity intermediate phenotypes for schizophrenia across different cognitive domains. PMID:26276700

  8. Defending to the Four Directions Evolving Uechi-ryu’s Hojoundo Exercises for Advanced Students

    Directory of Open Access Journals (Sweden)

    Ihor Rymaruk

    2012-07-01

    Full Text Available This article introduces “Defending to the Four Directions,” techniques that add challenge to Uechi-ryu while incorporating and building upon the traditional katas which have formed the basis of the style. Making changes within a style’s training methods just to be different without any other purpose is of little value and actually destructive to the system. This article describes a meaningful and realistic addition to the practice of hojoundo, the formal exercises incorporating basic movements. “Defending to the Four Directions” is intended for advanced students who have mastered Uechi-ryu’s foundamentals. In addition, the practice is well-suited for adaptation and adoption into other martial art styles.

  9. Advances in direct numerical simulation for MHD modeling of free surface flows

    International Nuclear Information System (INIS)

    The utilization of FLiBe (LiF-BeF2) free-surface flow as a chamber protection scheme is considered in advanced nuclear fusion reactor. At the design of the nuclear fusion reactor from the viewpoint of thermofluid research, it would be very important to understand the influence of a magnetic field in turbulent free surface flow. On the other hand, turbulent free surface flow (called open channel flow) by direct numerical simulation (DNS) with non-deformable surface was first succeeded by imposing free-slip and non-slip conditions as velocity boundary conditions at the upper and lower, respectively. After that, the research by DNS has been advanced more, it has been clarified that turbulent structures generated from the lower wall travels to the free surface and affected the mechanism of heat and mass transfer at the free surface. The behavior of the structures is affected by the strong magnetic field in the nuclear fusion reactor. Therefore, a DNS of liquid film cooling in the nuclear fusion reactor is performed by authors, and the relations between a magnetic orientation and turbulent flow statistics are clearly observed. In this paper, the DNS result is introduced, and the trial turbulence modeling for MHD free-surface flow by using the DNS database is also discussed

  10. Tuberculosis-advances in development of new drugs, treatment regimens, host-directed therapies, and biomarkers.

    Science.gov (United States)

    Wallis, Robert S; Maeurer, Markus; Mwaba, Peter; Chakaya, Jeremiah; Rustomjee, Roxana; Migliori, Giovanni Battista; Marais, Ben; Schito, Marco; Churchyard, Gavin; Swaminathan, Soumya; Hoelscher, Michael; Zumla, Alimuddin

    2016-04-01

    Tuberculosis is the leading infectious cause of death worldwide, with 9·6 million cases and 1·5 million deaths reported in 2014. WHO estimates 480 000 cases of these were multidrug resistant (MDR). Less than half of patients who entered into treatment for MDR tuberculosis successfully completed that treatment, mainly due to high mortality and loss to follow-up. These in turn illustrate weaknesses in current treatment regimens and national tuberculosis programmes, coupled with operational treatment challenges. In this Review we provide an update on recent developments in the tuberculosis drug-development pipeline (including new and repurposed antimicrobials and host-directed drugs) as they are applied to new regimens to shorten and improve outcomes of tuberculosis treatment. Several new or repurposed antimicrobial drugs are in advanced trial stages for MDR tuberculosis, and two new antimicrobial drug candidates are in early-stage trials. Several trials to reduce the duration of therapy in MDR and drug-susceptible tuberculosis are ongoing. A wide range of candidate host-directed therapies are being developed to accelerate eradication of infection, prevent new drug resistance, and prevent permanent lung injury. As these drugs have been approved for other clinical indications, they are now ready for repurposing for tuberculosis in phase 2 clinical trials. We assess risks associated with evaluation of new treatment regimens, and highlight opportunities to advance tuberculosis research generally through regulatory innovation in MDR tuberculosis. Progress in tuberculosis-specific biomarkers (including culture conversion, PET and CT imaging, and gene expression profiles) can support this innovation. Several global initiatives now provide unique opportunities to tackle the tuberculosis epidemic through collaborative partnerships between high-income countries and middle-income and low-income countries for clinical trials training and research, allowing funders to

  11. Advanced direct liquefaction concepts for PETC generic units. Final report, Phase I

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-03-01

    The Advanced Concepts for Direct Coal Liquefaction program was initiated by the Department of Energy in 1991 to develop technologies that could significantly reduce the cost of producing liquid fuels by the direct liquefaction of coal. The advanced 2-stage liquefaction technology that was developed at Wilsonville over the past 10 years has contributed significantly toward decreasing the cost of producing liquids from coal to about $33/bbl. It remains, however, the objective of DOE to further reduce this cost to a level more competitive with petroleum based products. This project, among others, was initiated to investigate various alternative approaches to develop technologies that might ultimately lead to a 25 % reduction in cost of product. In this project a number of novel concepts were investigated, either individually or in a coupled configuration that had the potential to contribute toward meeting the DOE goal. The concepts included mature technologies or ones closely related to them, such as coal cleaning by oil agglomeration, fluid coking and distillate hydrotreating and dewaxing. Other approaches that were either embryonic or less developed were chemical pretreatment of coal to remove oxygen, and dispersed catalyst development for application in the 2-stage liquefaction process. This report presents the results of this project. It is arranged in four sections which were prepared by participating organizations responsible for that phase of the project. A summary of the overall project and the principal results are given in this section. First, however, an overview of the process economics and the process concepts that were developed during the course of this program is presented.

  12. State of the art and challenges in development of electrical contact materials in the light of the RoHS directive

    Directory of Open Access Journals (Sweden)

    Ćosović V.

    2012-01-01

    Full Text Available The article surveys current state of the art and challenges in the development of the electrical contact materials in the light of the EU Directive on Restriction of Hazardous Substances (RoHS. The focus was placed on widely used silver-cadmium alloys. According to this directive, as of July 1, 2006, use of six hazardous materials, including cadmium, are restricted for applicable electrical and electronic products intended for the EU market. In contrast, traditionally preferred material for production of electrical contacts is Ag-CdO, due to its outstanding functional properties. These conflicting interests result in present state where RoHS directive has not yet been implemented in its original form and has undergone numerous amendments and exceptions regarding the use of cadmium. Main reason for this seems to be the unrealistic time frame imposed by legislation. Although, significant effort has been put into research and development of alternative materials, there are still cases where adequate replacement materials had not been found. Therefore, importance of synchronicity between legislation and technological progress i.e. communication between legislative administration and industry and academia is brought to light as well as some common issues that may arise with an introduction of new replacement materials or product modification. [Projekat Ministarstva nauke Republike SRbije, br. OI 172037 and TR 34023

  13. Advances in directed monooxygenase evolution : from diversity generation and flow cytometry screening to tailor-made monooxygenases

    OpenAIRE

    Ruff, Anna Joëlle

    2012-01-01

    Directed Evolution became a powerful tool for proteins engineers to generate tailor-made biocatalyst. Directed protein evolution consist of the following three consecutive main steps, which are performed in iterative cycles; Step 1 the gene diversity generation, Step 2 the screening for improved variants and Step 3 the isolation of gene encoding for improved proteins. In this thesis, methodological advancements in the two key steps of the directed evolution, the diversity generation (SeSaM me...

  14. Grafting Poly(3-hexylthiophene) from Silicon Nanocrystal Surfaces: Synthesis and Properties of a Functional Hybrid Material with Direct Interfacial Contact.

    Science.gov (United States)

    Islam, Muhammad Amirul; Purkait, Tapas K; Mobarok, Md Hosnay; Hoehlein, Ignaz M D; Sinelnikov, Regina; Iqbal, Muhammad; Azulay, Doron; Balberg, Isaac; Millo, Oded; Rieger, Bernhard; Veinot, Jonathan G C

    2016-06-20

    Hybrid functional materials (HFMs) comprised of semiconductor nanoparticles and conjugated polymers offer the potential of synergetic photophysical properties. We have developed HFMs based upon silicon nanocrystals (SiNCs) and the conductive polymer poly(3-hexylthiophene) (SiNC@P3HT) by applying surface-initiated Kumada catalyst transfer polycondensation (SI-KCTP). One unique characteristic of the developed SiNC@P3HT is the formation of a direct covalent bonding between SiNCs and P3HT. The presented method for obtaining direct interfacial attachment, which is not accessible using other methods, may allow for the development of materials with efficient electronic communication at the donor-acceptor interfaces. Systematic characterization provides evidence of a core-shell structure, enhanced interfacial electron and/or energy transfer between the P3HT and SiNC components, as well as formation of a type-II heterostructure. PMID:27144670

  15. Factors associated with the designation of a health care proxy and writing advance directives for patients suffering from haematological malignancies

    OpenAIRE

    Trarieux-Signol, Sophie; Moreau, Stéphane; Gourin, Marie-Pierre; Penot, Amélie; Edoux de Lafont, Geoffroy; Preux, Pierre-Marie; Bordessoule, Dominique

    2014-01-01

    Background During the last few decades, patients’ rights have been reinforced in many countries by acts of law. Measures now include health care proxies to uphold the doctor-patient relationship and advance directives for end-of-life patients. These could be relevant tools as early as the initial diagnosis of haematological malignancies because of the uncertain disease course. The aim of this research was to assess the factors associated with the designation of a proxy and writing advance dir...

  16. Ultraviolet/violet dual-color electroluminescence based on n-ZnO single crystal/p-GaN direct-contact light-emitting diode

    International Nuclear Information System (INIS)

    We have fabricated a fully transparent ultraviolet (UV)/violet dual-color electroluminescence (EL) device based on n-ZnO single crystal and p-GaN via a simple direct-contact method. The device presents dual-color EL under forward and reverse biases—an intense violet emission centered at 400 nm from ZnO and a sharp UV emission peaked at 365 nm from GaN, respectively. The reason for dual color emissions is proposed in terms of the energy band theory and the transmission spectra of ZnO single crystal and p-GaN. -- Highlights: ► A fully transparent LED based on n-ZnO SC and p-GaN is fabricated via the direct-contact method. ► The n-ZnO SC/p-GaN device shows UV/violet dual-color emission under electrically pumped. ► The device presents a violet emission 400 nm and a UV emission 365 nm under forward and reverse biases. ► The EL of the dual-color device displays good stability and reproducibility

  17. Direct human contact with siloxanes (silicones – safety or riskPart 1. Characteristics of siloxanes (silicones

    Directory of Open Access Journals (Sweden)

    Krystyna eMojsiewicz-Pieńkowska

    2016-05-01

    Full Text Available Siloxanes are commonly known as silicones. They belong to the organosilicon compounds and are exclusively obtained by synthesis. Their chemical structure determines a range of physicochemical properties which were recognized as unique. Due to the susceptibility to chemical modifications, ability to create short, long or complex polymer particles, siloxanes found an application in many areas of human life. Siloxanes differ in particle size, molecular weight, shape and chemical groups. As a result, this determines the different physico-chemical properties, that directly affect the safety or the risk of their use. The areas that can be a source of danger to human health will be commented in this paper.

  18. Perspectives on advance directives in Japanese society: A population-based questionnaire survey

    Directory of Open Access Journals (Sweden)

    Slingsby Brian

    2003-10-01

    Full Text Available Abstract Background In Japan, discussion concerning advance directives (ADs has been on the rise during the past decade. ADs are one method proposed to facilitate the process of communication among patients, families and health care providers regarding the plan of care of a patient who is no longer capable of communicating. In this paper, we report the results of the first in-depth survey on the general population concerning the preferences and use of ADs in Japan. Method A self-administered questionnaire was sent via mail to a stratified random sampling of 560 residents listed in the residential registry of one district of Tokyo, Japan (n = 165,567. Association between correlating factors and specific preferences toward ADs was assessed using contingency table bivariate analysis and multivariate regression model to estimate independent contribution. Results Of the 560 questionnaires sent out, a total of 425 participants took part in the survey yielding a response rate of 75.9 %. The results of the present study indicate that: 1 the most important components to be addressed are the specifics of medical treatment at the end of life stage and disclosure of diagnosis and prognosis; 2 the majority of participants found it suitable to express their directives by word to family and/or physician and not by written documentation; 3 there is no strong need for legal measures in setting up an AD; 4 it is permissible for family and physician to loosely interpret one's directives; 5 the most suitable proxy is considered to be a family member, relative, or spouse. Multivariate analysis found the following five factors as significantly associated with preferences: 1 awareness regarding living wills, 2 experience with the use of ADs, 3 preferences for end-of-life treatment, 4 preferences for information disclosure, and 5 intentions of creating a will. Conclusions Written ADs might be useful in the Japanese setting when the individual either wishes: 1 to not

  19. Lightning Radio Source Retrieval Using Advanced Lightning Direction Finder (ALDF) Networks

    Science.gov (United States)

    Koshak, William J.; Blakeslee, Richard J.; Bailey, J. C.

    1998-01-01

    A linear algebraic solution is provided for the problem of retrieving the location and time of occurrence of lightning ground strikes from an Advanced Lightning Direction Finder (ALDF) network. The ALDF network measures field strength, magnetic bearing and arrival time of lightning radio emissions. Solutions for the plane (i.e., no Earth curvature) are provided that implement all of tile measurements mentioned above. Tests of the retrieval method are provided using computer-simulated data sets. We also introduce a quadratic planar solution that is useful when only three arrival time measurements are available. The algebra of the quadratic root results are examined in detail to clarify what portions of the analysis region lead to fundamental ambiguities in source location. Complex root results are shown to be associated with the presence of measurement errors when the lightning source lies near an outer sensor baseline of the ALDF network. In the absence of measurement errors, quadratic root degeneracy (no source location ambiguity) is shown to exist exactly on the outer sensor baselines for arbitrary non-collinear network geometries. The accuracy of the quadratic planar method is tested with computer generated data sets. The results are generally better than those obtained from the three station linear planar method when bearing errors are about 2 deg. We also note some of the advantages and disadvantages of these methods over the nonlinear method of chi(sup 2) minimization employed by the National Lightning Detection Network (NLDN) and discussed in Cummins et al.(1993, 1995, 1998).

  20. Development of an Advanced Flow Meter using the Averaging Bi-directional Flow Tube

    International Nuclear Information System (INIS)

    Advanced flow meter using the concept of averaging bi-directional flow tube was developed. To find characteristics of flow meter and derive theory of measurement in the single and two phase flow condition, some basic tests were attempted using flow meters with diameters of 27, 80 and 200 mm. The CFD(computational fluid dynamics) calculation was also performed to find the effects of temperature and pressure, and to optimize design of a prototypic flow meter. Following this procedure, prototypical flow meters with diameters of 200 and 500 mm were designed and manufactured. It is aimed to use in the region in which calibration constant was unchanged. The stress analysis showed that the proposed flow meter of H-beam shape is inherently strong against the bending force induced by flow. The flow computer was developed for the flow rate calculation from the measured pressure difference. In this study, the performance test using this prototype flow meter was carried out. The developed flow meter can be applied in the wide range of pressure and temperature. The basic tests showed that the lineality of the proposed flow meter is ± 0.5 % of full scale and flow turn down ratio is 1:20 where the Reynolds number is larger than 10,000

  1. [Physicians' views and perspectives on advanced directives in patients with incipient dementia].

    Science.gov (United States)

    Mattiussi, Mercedes; Dawidowski, Adriana; Restibo, Jimena; Pollán, Javier; Pezzano, Laura; Cámera, Luis

    2012-01-01

    Dementia is a progressive disease in which patients lose their ability to decide and communicate. Advance directives (AD) allow patients to express their preferences on end of life care in the early stages of the disease. Primary care practitioners (PCP) are in the best position to promote AD. The aim of this study was to elicit PCPs views about the discussion of AD with early stage dementia patients. A qualitative approach was taken, focus groups and individual interviews to elderly patients' PCPs from the Hospital italiano de buenos aires were conducted. A purposive sampling was performed, conforming homogeneous groups according to age and seniority. The discussion was stimulated by a vignette. We performed thematic content analysis in an interdisciplinary team. Twelve PCPs = 30 year of age, 32 middle-aged and 8 over 45 years participated of the study. The youngest group favored the discussion of AD while those over 45 regarded the family as the decision maker, and thus, the discussion as useless. Besides, they expressed that our society is not mature enough to discuss AD. Difficulties in AD implementation, in predicting the evolution of a patient's disease, the span of time between the discussion and AD implementation, lack of legislation and specific institutional policies were other factors that conditioned the discussion. Younger PCPs expressed concern on the lack of communication skills and difficulties to broach this subject with patients. PCPs perspectives on AD vary, their age should be taken into account when designing strategies to their implementation. PMID:22892082

  2. Preparation and evaluation of the cytotoxic nature of TiO2 nanoparticles by direct contact method

    Directory of Open Access Journals (Sweden)

    Chellappa M

    2015-10-01

    Full Text Available M Chellappa,1 U Anjaneyulu,1 Geetha Manivasagam,2 U Vijayalakshmi1 1School of Advanced Sciences, Materials Chemistry Division, 2Centre for Biomaterials Science and Technology, School of Mechanical and Building Sciences, VIT University, Vellore, Tamil Nadu, India Abstract: The purpose of this study is to prepare and evaluate the effect of synthesized titanium dioxide (TiO2 nanoparticles for their biocompatibility on physiological body fluids and the effect of cell toxicity to produce osteointegration when used as implantable materials. For the past few decades, the number of researches done to understand the importance of the biocompatibility of bioceramics, metals, and polymers and their effect on clinical settings of biomedical devices has increased. Hence, the total concept of biocompatibility encourages researchers to actively engage in the investigation of the most compatible materials in living systems by analyzing them using suitable physical, chemical, and biological (bioassay methods. The ceramic material nano TiO2 was prepared by sol-gel method and analyzed for its functional group and phase formation by Fourier transform infrared spectroscopy and powder X-ray diffraction. Furthermore, the particle size, shape, surface topography, and morphological behavior were analyzed by dynamic light scattering, zeta potential, scanning electron microscopy–energy dispersive X-ray analysis, and transmission electron microscopy analysis. In addition to this, the cytotoxicity and cytocompatibility were determined on MG63 cell lines with varying doses of concentrations such as 1 µg/mL, 10 µg/mL, 25 µg/mL, 50 µg/mL, and 100 µg/mL with different time periods such as 24 hours and 48 hours. The results have not shown any toxicity, whereas, it improved the cell viability/proliferation at various concentrations. Hence, these findings indicate that the nano TiO2 material acts as a good implantable material when used in the biomedical field as a

  3. γ-Aminobutyric Acid Type A (GABAA) Receptor Subunits Play a Direct Structural Role in Synaptic Contact Formation via Their N-terminal Extracellular Domains.

    Science.gov (United States)

    Brown, Laura E; Nicholson, Martin W; Arama, Jessica E; Mercer, Audrey; Thomson, Alex M; Jovanovic, Jasmina N

    2016-07-01

    The establishment of cell-cell contacts between presynaptic GABAergic neurons and their postsynaptic targets initiates the process of GABAergic synapse formation. GABAA receptors (GABAARs), the main postsynaptic receptors for GABA, have been recently demonstrated to act as synaptogenic proteins that can single-handedly induce the formation and functional maturation of inhibitory synapses. To establish how the subunit composition of GABAARs influences their ability to induce synaptogenesis, a co-culture model system incorporating GABAergic medium spiny neurons and the HEK293 cells, stably expressing different combinations of receptor subunits, was developed. Analyses of HEK293 cell innervation by medium spiny neuron axons using immunocytochemistry, activity-dependent labeling, and electrophysiology have indicated that the γ2 subunit is required for the formation of active synapses and that its effects are influenced by the type of α/β subunits incorporated into the functional receptor. To further characterize this process, the large N-terminal extracellular domains (ECDs) of α1, α2, β2, and γ2 subunits were purified using the baculovirus/Sf9 cell system. When these proteins were applied to the co-cultures of MSNs and α1/β2/γ2-expressing HEK293 cells, the α1, β2, or γ2 ECD each caused a significant reduction in contact formation, in contrast to the α2 ECD, which had no effect. Together, our experiments indicate that the structural role of GABAARs in synaptic contact formation is determined by their subunit composition, with the N-terminal ECDs of each of the subunits directly participating in interactions between the presynaptic and postsynaptic elements, suggesting the these interactions are multivalent and specific. PMID:27129275

  4. Direct patterning of metallic micro/nano-structures on flexible polymer substrates by roller-based contact printing and infrared heating

    International Nuclear Information System (INIS)

    This paper presents a new micro/nano-fabrication method which can directly transfer a patterned metallic film from a silicon mold to a flexible polymer substrate. The basic idea is to coat a metallic thin layer on a silicon mold which has pre-defined surface features in micro- or nano-scale. Prior to the metallic film deposition, an anti-adhesion layer is first applied to the mold's surface so that the subsequently deposited metallic layer is only weakly attached to the mold. The silicon mold is then pressed by a roller against a polymer substrate while an infrared light source, such as an infrared lamp, is used to heat up the mold/substrate assembly. Energy of the infrared heating source is absorbed by the metal layer and subsequently heats up the polymer material in contact with the metal film through heat conduction. The temperature rising and the contact pressure at the metal/polymer interface create a stronger bonding interface which finally transfers the metallic patterns defined by the mold's surface features to the polymer substrate. Experiments have been carried out to demonstrate the feasibility and capabilities of the proposed method. Metallic structures with a smallest feature size of 60 nm and an imprinted area of 4 × 4 cm2 have been successfully patterned into PET films.

  5. Recent Advances in Solution NMR: Fast Methods and Heteronuclear Direct Detection

    International Nuclear Information System (INIS)

    Today, NMR spectroscopy is the technique of choice to investigate molecular structure, dynamics, and interactions in solution at atomic resolution. A major limitation of NMR spectroscopy for the study of biological macromolecules such as proteins, nucleic acids, and their complexes, has always been its low sensitivity, a consequence of the weak magnetic spin interactions. Therefore many efforts have been invested in the last decade to improve NMR instrumentation in terms of experimental sensitivity. As a result of these efforts, the availability of high-field magnets, cryogenically cooled probes, and probably in the near future hyper-polarization techniques, the intrinsic NMR sensitivity has increased by at least one order of magnitude. Stimulated by new challenges in the life sciences, these technical improvements have triggered the development of new NMR methods for the study of molecular systems of increasing size and complexity. Herein, we focus on two examples of recently developed NMR methodologies. First, advanced multidimensional data acquisition schemes provide a speed increase of several orders of magnitude. Second, NMR methods based on the direct detection of low-gamma nuclei present a new spectroscopic tool, highly complementary to conventional NMR techniques. These new methods provide powerful new NMR tools for the study of short-lived molecules, large and intrinsically unstructured proteins, paramagnetic systems, as well as for the characterization of molecular kinetic processes at atomic resolution. These examples illustrate how NMR is continuously adapting to the new challenges in the life sciences, with the focus shifting from the characterization of single biomolecules to an integrated view of interacting molecular networks observed at varying levels of biological organization. (authors)

  6. [Advance directives in Italy: a goal not yet reached but already passed?].

    Science.gov (United States)

    Riccioni, Luigi; Gristina, Giuseppe

    2015-10-01

    The advance directives (ADs) have been adopted in many countries to defend patients' autonomy. In Italy, in the past, this topic gave rise to a heated debate involving philosophers, theologians, and politicians. In 2009, the government presented a bill of law on ADs firmly criticized from a scientific, moral and juridical point of view because the bill's content is against the principles of Italian Constitution, Italian Code of Medical Ethics, Oviedo Convention, and official statements of many scientific societies. Although the bill has passed the Low Chamber it lies, even since, in the Senate, lacking in regard any agreement among the political parties. The purpose of this article is to highlight that, in our country, patients, relatives and doctors deserve a law not only related to the specific topic of ADs, but - as in other European countries (Germany, Spain, France, UK) - aimed to deal with the complex issue of end of life care as a whole. This law should take into account the sound evidence existing in regard to the four fundamental principles supporting the best scientific and ethical approaches to the end of life issues: shared decision making process between doctors and patients/relatives; rejection of dying process marked by the suffering; withholding/withdrawing futile treatments together with palliative sedation as two crucial contributions to suppress the patient suffering and pain; clear-cut difference between these clinical/ethical options and euthanasia. At the same time, this law should be able to provide physicians with a legal coverage to make all the clinical and ethical decisions more and more complex because of the continuous evolution of medical science on one hand, and the impressive development of biotechnology on the other hand. PMID:26442974

  7. Default options in advance directives: study protocol for a randomised clinical trial

    Science.gov (United States)

    Gabler, Nicole B; Cooney, Elizabeth; Small, Dylan S; Troxel, Andrea B; Arnold, Robert M; White, Douglas B; Angus, Derek C; Loewenstein, George; Volpp, Kevin G; Bryce, Cindy L; Halpern, Scott D

    2016-01-01

    Introduction Although most seriously ill Americans wish to avoid burdensome and aggressive care at the end of life, such care is often provided unless patients or family members specifically request otherwise. Advance directives (ADs) were created to provide opportunities to set limits on aggressive care near life's end. This study tests the hypothesis that redesigning ADs such that comfort-oriented care is provided as the default, rather than requiring patients to actively choose it, will promote better patient-centred outcomes. Methods and analysis This multicentre trial randomises seriously ill adults to receive 1 of 3 different ADs: (1) a traditional AD that requires patients to actively choose their goals of care or preferences for specific interventions (eg, feeding tube insertion) or otherwise have their care guided by their surrogates and the prevailing societal default toward aggressive care; (2) an AD that defaults to life-extending care and receipt of life-sustaining interventions, enabling patients to opt out from such care; or (3) an AD that defaults to comfort care, enabling patients to opt into life-extending care. We seek to enrol 270 patients who return complete, legally valid ADs so as to generate sufficient power to detect differences in the primary outcome of hospital-free days (days alive and not in an acute care facility). Secondary outcomes include hospital and intensive care unit admissions, costs of care, hospice usage, decision conflict and satisfaction, quality of life, concordance of preferences with care received and bereavement outcomes for surrogates of patients who die. Ethics and dissemination This study has been approved by the Institutional Review Boards at all trial centres, and is guided by a data safety and monitoring board and an ethics advisory board. Study results will be disseminated using methods that describe the results in ways that key stakeholders can best understand and implement. Trial registration number NCT02017548

  8. Direct contacts between conserved motifs of different subunits provide major contribution to active site organization in human and mycobacterial dUTPases.

    Science.gov (United States)

    Takács, Eniko; Nagy, Gergely; Leveles, Ibolya; Harmat, Veronika; Lopata, Anna; Tóth, Judit; Vértessy, Beáta G

    2010-07-16

    dUTP pyrophosphatases (dUTPases) are essential for genome integrity. Recent results allowed characterization of the role of conserved residues. Here we analyzed the Asp/Asn mutation within conserved Motif I of human and mycobacterial dUTPases, wherein the Asp residue was previously implicated in Mg(2+)-coordination. Our results on transient/steady-state kinetics, ligand binding and a 1.80 A resolution structure of the mutant mycobacterial enzyme, in comparison with wild type and C-terminally truncated structures, argue that this residue has a major role in providing intra- and intersubunit contacts, but is not essential for Mg(2+) accommodation. We conclude that in addition to the role of conserved motifs in substrate accommodation, direct subunit interaction between protein atoms of active site residues from different conserved motifs are crucial for enzyme function. PMID:20493855

  9. Toxicological evaluation of liquids proposed for use in direct contact liquid--liquid heat exchangers for solar heated and cooled buildings

    Energy Technology Data Exchange (ETDEWEB)

    Buchan, R.M.; Majestic, J.R.; Billau, R.

    1976-09-01

    This report contains the results of the toxicological evaluation part of the project entitled, ''Direct Contact Liquid-Liquid Heat Exchangers for Solar Heated and Cooled Buildings.'' Obviously any liquid otherwise suitable for use in such a device should be subjected to a toxicological evaluation. 34 liquids (24 denser than water, 10 less dense) have physical and chemical properties that would make them suitable for use in such a device. In addition to the complexity involved in selecting the most promising liquids from the standpoint of their chemical and physical properties is added the additional difficulty of also considering their toxicological properties. Some of the physical and chemical properties of these liquids are listed. The liquids are listed in alphabetical order within groups, the denser than water liquids are listed first followed by those liquids less dense than water.

  10. Direct observation of both contact and remote oxygen scavenging of GeO2 in a metal-oxide-semiconductor stack

    International Nuclear Information System (INIS)

    In the path to incorporating Ge based metal-oxide-semiconductor into modern nano-electronics, one of the main issues is the oxide-semiconductor interface quality. Here, the reactivity of Ti on Ge stacks and the scavenging effect of Ti were studied using synchrotron X-ray photoelectron spectroscopy measurements, with an in-situ metal deposition and high resolution transmission electron microscopy imaging. Oxygen removal from the Ge surface was observed both in direct contact as well as remotely through an Al2O3 layer. The scavenging effect was studied in situ at room temperature and after annealing. We find that the reactivity of Ti can be utilized for improved scaling of Ge based devices.

  11. The role of advance directives in end-of-life decisions in Austria: survey of intensive care physicians

    Directory of Open Access Journals (Sweden)

    Schopper Andrea

    2010-10-01

    Full Text Available Abstract Background Currently, intensive care medicine strives to define a generally accepted way of dealing with end-of-life decisions, therapy limitation and therapy discontinuation. In 2006 a new advance directive legislation was enacted in Austria. Patients may now document their personal views regarding extension of treatment. The aim of this survey was to explore Austrian intensive care physicians' experiences with and their acceptance of the new advance directive legislation two years after enactment (2008. Methods Under the aegis of the OEGARI (Austrian Society of Anaesthesiology, Resuscitation and Intensive Care an anonymised questionnaire was sent to the medical directors of all intensive care units in Austria. The questions focused on the physicians' experiences regarding advance directives and their level of knowledge about the underlying legislation. Results There were 241 questionnaires sent and 139 were turned, which was a response rate of 58%. About one third of the responders reported having had no experience with advance directives and only 9 directors of intensive care units had dealt with more than 10 advance directives in the previous two years. Life-supporting measures, resuscitation, and mechanical ventilation were the predominantly refused therapies, wishes were mainly expressed concerning pain therapy. Conclusion A response rate of almost 60% proves the great interest of intensive care professionals in making patient-oriented end-of-life decisions. However, as long as patients do not make use of their right of co-determination, the enactment of the new law can be considered only a first important step forward.

  12. Advancements in the development of a directional-position sensing fast neutron detector using acoustically tensioned metastable fluids

    Science.gov (United States)

    Archambault, Brian C.; Webster, Jeffrey A.; Grimes, Thomas F.; Fischer, Kevin F.; Hagen, Alex R.; Taleyakhan, Rusi P.

    2015-06-01

    Advancements in the development of a direction and position sensing fast neutron detector which utilizes the directional acoustic tensioned metastable fluid detector (D-ATMFD) are described. The resulting D-ATMFD sensor is capable of determining the direction of neutron radiation with a single compact detector versus use of arrays of detectors in conventional directional systems. Directional neutron detection and source positioning offer enhanced detection speeds in comparison to traditional proximity searching; including enabling determination of the neutron source shape, size, and strength in near real time. This paper discusses advancements that provide the accuracy and precision of ascertaining directionality and source localization information utilizing enhanced signal processing-cum-signal analysis, refined computational algorithms, and on-demand enlargement capability of the detector sensitive volume. These advancements were accomplished utilizing experimentation and theoretical modeling. Benchmarking and qualifications studies were successfully conducted with random and fission based special nuclear material (SNM) neutron sources (239Pu-Be and 252Cf). These results of assessments have indicated that the D-ATMFD compares well in technical performance with banks of competing directional fast neutron detector technologies under development worldwide, but it does so with a single detector unit, an unlimited field of view, and at a significant reduction in both cost and size while remaining completely blind to common background (e.g., beta-gamma) radiation. Rapid and direct SNM neutron source imaging with two D-ATMFD sensors was experimentally demonstrated, and furthermore, validated via multidimensional nuclear particle transport simulations utilizing MCNP-PoliMi. Characterization of a scaled D-ATMFD based radiation portal monitor (RPM) as a cost-effective and efficient 3He sensor replacement was performed utilizing MCNP-PoliMi simulations, the results of which

  13. Advancements in the development of a directional-position sensing fast neutron detector using acoustically tensioned metastable fluids

    International Nuclear Information System (INIS)

    Advancements in the development of a direction and position sensing fast neutron detector which utilizes the directional acoustic tensioned metastable fluid detector (D-ATMFD) are described. The resulting D-ATMFD sensor is capable of determining the direction of neutron radiation with a single compact detector versus use of arrays of detectors in conventional directional systems. Directional neutron detection and source positioning offer enhanced detection speeds in comparison to traditional proximity searching; including enabling determination of the neutron source shape, size, and strength in near real time. This paper discusses advancements that provide the accuracy and precision of ascertaining directionality and source localization information utilizing enhanced signal processing-cum-signal analysis, refined computational algorithms, and on-demand enlargement capability of the detector sensitive volume. These advancements were accomplished utilizing experimentation and theoretical modeling. Benchmarking and qualifications studies were successfully conducted with random and fission based special nuclear material (SNM) neutron sources (239Pu–Be and 252Cf). These results of assessments have indicated that the D-ATMFD compares well in technical performance with banks of competing directional fast neutron detector technologies under development worldwide, but it does so with a single detector unit, an unlimited field of view, and at a significant reduction in both cost and size while remaining completely blind to common background (e.g., beta-gamma) radiation. Rapid and direct SNM neutron source imaging with two D-ATMFD sensors was experimentally demonstrated, and furthermore, validated via multidimensional nuclear particle transport simulations utilizing MCNP-PoliMi. Characterization of a scaled D-ATMFD based radiation portal monitor (RPM) as a cost-effective and efficient 3He sensor replacement was performed utilizing MCNP-PoliMi simulations, the results of

  14. Advance directives and nursing home stays associated with less aggressive end-of-life care for patients with severe dementia.

    Science.gov (United States)

    Nicholas, Lauren H; Bynum, Julie P W; Iwashyna, Theodore J; Weir, David R; Langa, Kenneth M

    2014-04-01

    The number of older adults with cognitive impairment is increasing, and such adults often require a surrogate to make decisions about health care. However, little is known about the aggressiveness of end-of-life care for these people, especially those who reside in the community. We found that cognitive impairment is common among older adults approaching the end of life, whether they live in the community or in a nursing home, and that nearly 30 percent of patients with severe dementia remained in the community until death. Among those patients, having an advance directive in the form of a living will was associated with significantly less aggressive care at the end of life, compared to similar patients without an advance directive-as measured by Medicare spending ($11,461 less per patient), likelihood of in-hospital death (17.9 percentage points lower), and use of the intensive care unit (9.4 percentage points lower). In contrast, advance directives were not associated with differences in care for people with normal cognition or mild dementia, whether they resided in the community or in a nursing home. Timely advance care planning after a diagnosis of cognitive impairment may be particularly important for older adults who reside in the community. PMID:24711329

  15. Sigma Team for Advanced Actinide Recycle FY2015 Accomplishments and Directions

    Energy Technology Data Exchange (ETDEWEB)

    Moyer, Bruce A. [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

    2015-09-30

    noncomplexing aqueous solution and submission of this scientific breakthrough as a paper in Science; The first-ever co-crystallization of Am(VI) with UO2(NO3)2 ∙ 6H2O, opening the door to a new approach for separating hexavalent actinides as a group; Results showing that three potentially problematic metals will not present risk in ALSEP; Improvement in ALSEP contactor stripping kinetics to acceptable performance; A comparison of centrifugal contactors vs mixer-settlers showing the former performs better in ALSEP stripping; Synthesis of new mixed N,O-donor extractants with enhanced solubility and strength for selective trivalent actinide extraction; Development of computational methods showing promise in prediction of the selectivity of new extractants for trivalent actinides vs lanthanides; An order-of-magnitude improvement in aqueous Am/Eu complexation selectivity of an alternative macrocyclic stripping agent for ALSEP, potentially enabling an option for an Am product stream free from both Ln and Cm. An alternative aqueous combination of dipicolinate complexant and malonate buffer that may present options for ALSEP and TALSPEAK (Trivalent Actinide-Lanthanide Separations by Phosphorus-reagent Extraction from Aqueous Komplexes) type separations. The ALSEP concept is advancing toward a benchtop flowsheet demonstration planned for FY 2016, and a bench-scale test bed at Idaho National Laboratory (INL) will be employed to demonstrate at least one tandem Am oxidation and separation concept. This report outlines the goals of the STAAR, significance of achieving these goals, STAAR organization around the above aims and questions, recent highlights, and future directions. The report also includes a listing of publications, reports, patents, and dissertations.

  16. Direct and indirect contact effect between Al and TiO2 on the conduction mechanism for polymer-TiO2 Schottky diodes

    International Nuclear Information System (INIS)

    Two kinds of Schottky diodes comprising an of Al/a mixture of TiO2 nanoparticles and poly(3,4-ethylenedioxythiophene) : poly(4-styrenesulfonate) (PEDOT : PSS)/Au and Al/TiO2/PEDOT : PSS/Au were fabricated to investigate the effect of direct and indirect contacts of Al/TiO2 on the conduction mechanism. A mixture of TiO2 nanoparticles and PEDOT : PSS was coated to fabricate an Al/TiO2-PEDOT : PSS/Au Schottky diode (IATPA). TiO2 nanoparticles were directly coated on the Al electrode prior to PEDOT : PSS coating to fabricate an Al/TiO2/PEDOT : PSS/Au Schottky diode (DATPA). The forward current of DATPA increased by more than three-fold with respect to that of IATPA. Three conduction models including space charge limited conduction (SCLC), Schottky conduction and Poole-Frenkel conduction (PFC) models were employed to analyse the conduction mechanism. The major conduction mechanisms for both IATPA and DATPA closely follow the SCLC and PFC models. Higher slope and bigger beta value than those of the theoretical SCLC and PFC models for the DATPA indicate more involvement of the PFC mechanism in SCLC or vice versa. The reason for following the SCLC mechanism might be the low conductive property of PEDOT : PSS and the reason for following the PFC mechanism may be the partial positive and negative charges of the PEDOT : PSS.

  17. Technologies for hydrogen production based on direct contact of gaseous hydrocarbons and evaporated water with Molten Pb or Pb-Bi

    International Nuclear Information System (INIS)

    Results of studies intended for the substantiation of a new energy-saving and safe technology for low cost hydrogen production have been presented. The technology's basis is direct mixing of water and (or) gaseous hydrocarbons with heavy liquid metal coolants (HLMC) Pb or Pb-Bi. Preliminary research has been done on thermal dynamics and kinetics of the processes taking place in the interaction of HLMC with hydrocarbon-containing gases. It has been shown as a result that water and gaseous hydrocarbons interact with molten Pb and Pb-Bi relatively quietly in chemical aspect (without ignition and explosions). Therefore, (and taking into account the thermal physics, physical and chemical properties of HLMC such as low pressure of saturated vapor of Pb and Pb- Bi in enhanced temperatures, their good heat conductivity and heat capacity, low viscosity, etc.) heat transfer is possible from the molten metal to water and hydrocarbons without heat transferring partitions (that is, by direct contact of the working media). Devices to implement this method of heating liquid and gaseous media provide essential advantages: - A simple design; - None heat-transferring surfaces subject to corrosion, contamination, thermal fatigue, vibration impacts; - A high effectiveness owing to a larger heat exchanging surface per volume unit; - A small hydraulic resistance. The possibility and effectiveness of heating various gaseous and liquid media in their direct contact with molten Pb and Pb-Bi has been substantiated convincingly by experimental results at IPPE. Besides, the following processes of hydrogen-containing media conversion have been proved feasible thereby. 1. Water decomposition into hydrogen and oxygen. The process can develop at temperatures of 400-1000 degree C. It is necessary to provide constant removal of oxygen from the reaction zone and maintain a minimum possible content of chemically active oxygen in the melt. 2. Pyrolytic decomposition of hydrocarbons into carbon and

  18. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... same level of care or consideration as a standard contact lens because they can be purchased over- ... lifestyle choices can directly affect your eyes. The best way to take care of your eyes during ...

  19. Telocyte's contacts.

    Science.gov (United States)

    Faussone-Pellegrini, Maria-Simonetta; Gherghiceanu, Mihaela

    2016-07-01

    Telocytes (TC) are an interstitial cell type located in the connective tissue of many organs of humans and laboratory mammals. By means of homocellular contacts, TC build a scaffold whose meshes integrity and continuity are guaranteed by those contacts having a mechanical function; those contacts acting as sites of intercellular communication allow exchanging information and spreading signals. Heterocellular contacts between TC and a great variety of cell types give origin to mixed networks. TC, by means of all these types of contacts, their interaction with the extracellular matrix and their vicinity to nerve endings, are part of an integrated system playing tissue/organ-specific roles. PMID:26826524

  20. Inapplicability of advance directives in a paternalistic setting: the case of a post-communist health system

    OpenAIRE

    Kruja Jera; Vyshka Gentian

    2011-01-01

    Abstract Background The Albanian medical system and Albanian health legislation have adopted a paternalistic position with regard to individual decision making. This reflects the practices of a not-so-remote past when state-run facilities and a totalitarian philosophy of medical care were politically imposed. Because of this history, advance directives concerning treatment refusal and do-not-resuscitate decisions are still extremely uncommon in Albania. Medical teams cannot abstain from inter...

  1. Advance Directives for End-of-Life Care and the Role of Health Education Specialists: Applying the Theory of Reasoned Action

    Science.gov (United States)

    Tremethick, Mary Jane; Johnson, Maureen K.; Carter, Mary R.

    2011-01-01

    Quality end-of-life care is subjective and based on individual values and beliefs. An advance directive provides a legal means of communicating these values and beliefs, as well as preferences in regards to end-of-life care when an individual is no longer able to make his or her desires known. In many nations, advance directives are underused…

  2. Engaging Men and Boys in Advancing Women's Agency : Where We Stand and New Directions

    OpenAIRE

    Fleming, Paul J.; Barker, Gary; McCleary-Sills, Jennifer; Morton, Matthew

    2013-01-01

    Despite advances in gender equality, women and girls still face disadvantages and limits on their agency. Men and boys can be key stakeholders and allies to increase women's agency. This paper focuses on examining men's attitudes and behaviors related to gender equality and violence perpetration to better understand how to engage men and boys as. It uses data collected from men and women f...

  3. A Framework for Better Understanding and Enhancing Direct Contact Membrane Distillation (DCMD) in Terms of Module Design, Cost Analysis and Energy Required

    KAUST Repository

    AbuHannoud, Ali

    2011-07-01

    Water is becoming scarcer and several authors have highlighted the upcoming problem of higher water salinity and the difficulty of treating and discharging water. Moreover, current discoveries of problems with chemicals that have been used for pretreating or post-treating water alerted scientists to research better solutions to treat water. Membrane distillation (MD) is a promising technology that might replace current processes as it has lower pretreatment requirements combined with a tremendous ability to treat a wide range of feed sources while producing very high product quality. If it enters the market, it will have a big influence on all products, from food industry to spaceflight. However, there are several problems which make MD a hot topic for research. One of them is the question about the real cost of MD in terms of heating feed and cooling distillate over time with respect to product quantity and quality. In this work, extensive heating and cooling analyses are covered to answer this question in order to enhance the MD process. Results show energy cost to produce water and the main source of energy loss for direct contact membrane distillation (DCMD), and several suggestions are made in order to better understand and hence enhance the process.

  4. A direct contact between astrocyte and vitreous body is possible in the rabbit eye due to discontinuities in the basement membrane of the retinal inner limiting membrane

    Directory of Open Access Journals (Sweden)

    A. Haddad

    2003-02-01

    Full Text Available Different from most mammalian species, the optic nerve of the rabbit eye is initially formed inside the retina where myelination of the axons of the ganglion cells starts and vascularization occurs. Astrocytes are confined to these regions. The aforementioned nerve fibers known as medullated nerve fibers form two bundles that may be identified with the naked eye. The blood vessels run on the inner surface of these nerve fiber bundles (epivascularization and, accordingly, the accompanying astrocytes lie mostly facing the vitreous body from which they are separated only by the inner limiting membrane of the retina. The arrangement of the astrocytes around blood vessels leads to the formation of structures known as glial tufts. Fragments (N = 3 or whole pieces (N = 3 of the medullated nerve fiber region of three-month-old male rabbits (Orictolagus cuniculus were fixed in glutaraldehyde followed by osmium tetroxide, and their thin sections were examined with a transmission electron microscope. Randomly located discontinuities (up to a few micrometers long of the basement membrane of the inner limiting membrane of the retina were observed in the glial tufts. As a consequence, a direct contact between the astrocyte plasma membrane and vitreous elements was demonstrated, making possible functional interactions such as macromolecular exchanges between this glial cell type and the components of the vitreous body.

  5. Mechanistic approaches to understanding and predicting mammalian space use: Recent advances, future directions

    OpenAIRE

    Moorcroft, Paul R.

    2012-01-01

    The coming of age of global positioning system telemetry, in conjunction with recent theoretical innovations for formulating quantitative descriptions of how different ecological forces and behavioral mechanisms shape patterns of animal space use, has led to renewed interest and insight into animal home-range patterns. This renaissance is likely to continue as a result of ongoing synergies between these empirical and theoretical advances. In this article I review key developments that have oc...

  6. Imaging-Genetics in Autism Spectrum Disorder: Advances, Translational Impact, and Future Directions

    OpenAIRE

    StephanieH.Ameis; PeterSzatmari

    2012-01-01

    Autism Spectrum Disorder (ASD) refers to a group of heterogeneous neurodevelopmental disorders that are unified by impairments in reciprocal social communication and a pattern of inflexible behaviors. Recent genetic advances have resolved some of the complexity of the genetic architecture underlying ASD by identifying several genetic variants that contribute to the disorder. Different etiological pathways associated with ASD may converge through effects on common molecular mechanisms, such as...

  7. Induction of mucosal immune responses and protection of cattle against direct-contact challenge by intranasal delivery with foot-and-mouth disease virus antigen mediated by nanoparticles

    Directory of Open Access Journals (Sweden)

    Pan L

    2014-12-01

    Full Text Available Li Pan,1,2 Zhongwang Zhang,1,2 Jianliang Lv,1,2 Peng Zhou,1,2 Wenfa Hu,1,2 Yuzhen Fang,1,2 Haotai Chen,1,2 Xinsheng Liu,1,2 Junjun Shao,1,2 Furong Zhao,1,2 Yaozhong Ding,1,2 Tong Lin,1,2 Huiyun Chang,1,2 Jie Zhang,1,2 Yongguang Zhang,1,2 Yonglu Wang1,2 1State Key Laboratory of Veterinary Etiological Biology, National Foot-and-Mouth Disease Reference Laboratory, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences (CAAS, Lanzhou, Gansu, People’s Republic of China; 2Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou, People’s Republic of China Abstract: The aim of this study was to enhance specific mucosal, systemic, and cell-mediated immunity and to induce earlier onset of protection against direct-contact challenge in cattle by intranasal delivery of a nanoparticle-based nasal vaccine against type A foot-and-mouth disease (FMD. In this study, two kinds of nanoparticle-based nasal vaccines against type A FMD were designed: (1 chitosan-coated poly(lactic-co-glycolic acid (PLGA loaded with plasmid DNA (Chi-PLGA-DNA and (2 chitosan-trehalose and inactivated foot-and-mouth disease virus (FMDV (Chi-Tre-Inactivated. Cattle were immunized by an intranasal route with nanoparticles and then challenged for 48 hours by direct contact with two infected donor cattle per pen. Donors were inoculated intradermally in the tongue 48 hours before challenge, with 0.2 mL cattle-passaged FMDV. Serological and mucosal antibody responses were evaluated, and virus excretion and the number of contact infections were quantified. FMDV-specific secretory immunoglobulin (IgA (sIgA antibodies in nasal washes were initially detected at 4 days postvaccination (dpv with two kinds of nanoparticles. The highest levels of sIgA expression were observed in nasal washes, at 10 dpv, from animals with Chi-PLGA-DNA nanoparticles, followed by animals immunized once by intranasal route with

  8. Direct contact of indium tin oxide layer to Al(Ni) alloy electrodes for a-Si:H thin film transistors: Effects of Ni alloying on interfacial oxide growth and contact resistance

    International Nuclear Information System (INIS)

    Sputtering of indium tin oxide (ITO) on pure Al substrate produces an Al2O3 layer at the interface, leading to Schottky contact characteristics. A very small amount of Ni (2 at.% Ni) added to Al drastically reduces the contact resistance of an ITO/Al(Ni) alloy electrode to approximately 4.3 × 10-4 Ω-cm2, with a low electrical resistivity of ∼ 3 μΩ-cm, demonstrating the feasibility of using ITO/Al(Ni) alloy structures as electrodes for a-Si:H thin film transistors. The mechanism for initial interfacial oxidation occurring during sputtering of ITO on the surface of Al(Ni) and subsequent annealing at 320 °C was proposed to reveal the role of Ni during the sputtering and annealing processes. - Highlights: • Indium tin oxide (ITO)/Al(Ni) alloy contacts were fabricated. • Contact resistance of ITO/Al(Ni) alloy varied with Ni content. • Mechanism for initial interfacial oxidation during sputtering of ITO was proposed

  9. Recent advances in direct-drive ICF target physics at the laboratory for laser energetics

    International Nuclear Information System (INIS)

    The principal role of the Laboratory for Laser Energetics (LLE) is the development and validation of the direct-drive approach to inertial fusion. The LLE experimental and theoretical programs in support of this mission were organized to provide a moderate-gain option for the U.S. National Ignition Facility (NIF). Experimental implementation of the LLE program is carried out on the LLE's 30-kJ, 60-beam, UV OMEGA laser. This paper summarizes the status of the direct-drive ICF physics program at LLE with emphasis on the development of beam-smoothing techniques, long-scale-length plasma interaction experiments, direct-drive planar-foil hydrodynamic instability experiments, the effect of laser nonuniformity on target stability, integrated spherical target implosion experiments, design of direct-drive targets, development of target diagnostic techniques, and implementation of cryogenic-fuel-layering technology. (author)

  10. Direct methods for limit and shakedown analysis of structures advanced computational algorithms and material modelling

    CERN Document Server

    Pisano, Aurora; Weichert, Dieter

    2015-01-01

    Articles in this book examine various materials and how to determine directly the limit state of a structure, in the sense of limit analysis and shakedown analysis. Apart from classical applications in mechanical and civil engineering contexts, the book reports on the emerging field of material design beyond the elastic limit, which has further industrial design and technological applications. Readers will discover that “Direct Methods” and the techniques presented here can in fact be used to numerically estimate the strength of structured materials such as composites or nano-materials, which represent fruitful fields of future applications.   Leading researchers outline the latest computational tools and optimization techniques and explore the possibility of obtaining information on the limit state of a structure whose post-elastic loading path and constitutive behavior are not well defined or well known. Readers will discover how Direct Methods allow rapid and direct access to requested information in...

  11. Recent advances in direct-drive ICF target physics at the Laboratory for Laser Energetics

    International Nuclear Information System (INIS)

    The principal role of the Laboratory for Laser Energetics (LLE) is the development and validation of the direct-drive approach to inertial fusion. The LLE experimental and theoretical programs in support of this mission were organized to provide a moderate-gain option for the U.S. National Ignition Facility (NIF). Experimental implementation of the LLE program is carried out on the LLE's 30-kJ, 60-beam, UV OMEGA laser. This paper summarizes the status of the direct-drive ICF physics program at LLE with emphasis on the development of beam-smoothing techniques, long-scale-length plasma interaction experiments, direct-drive planar-foil hydrodynamic instability experiments, the effect of laser nonuniformity on target stability, integrated spherical target implosion experiments, design of direct-drive targets, development of target diagnostic techniques, and implementation of cryogenic-fuel-layering technology. (author)

  12. Family consent, communication, and advance directives for cancer disclosure: a Japanese case and discussion.

    OpenAIRE

    Akabayashi, A.; Fetters, M. D.; Elwyn, T S

    1999-01-01

    The dilemma of whether and how to disclose a diagnosis of cancer or of any other terminal illness continues to be a subject of worldwide interest. We present the case of a 62-year-old Japanese woman afflicted with advanced gall bladder cancer who had previously expressed a preference not to be told a diagnosis of cancer. The treating physician revealed the diagnosis to the family first, and then told the patient: "You don't have any cancer yet, but if we don't treat you, it will progress to a...

  13. Comparative study of electrical characteristics in (1 0 0) and (1 1 0) surface-oriented nMOSFETs with direct contact La-silicate/Si interface structure

    Science.gov (United States)

    Kawanago, T.; Kakushima, K.; Ahmet, P.; Kataoka, Y.; Nishiyama, A.; Sugii, N.; Tsutsui, K.; Natori, K.; Hattori, T.; Iwai, H.

    2013-06-01

    This study reports on the electrical characteristics of (1 1 0)-oriented nMOSFETs with a direct contact La-silicate/Si interface structure and the detailed comparison with (1 0 0)-oriented nMOSFETs. Precise control of oxygen partial pressure can provide the scaled EOT down to 0.73 nm on (1 1 0) orientation in common with (1 0 0) orientation. No frequency dispersion in Cgc-V characteristic for (1 1 0)-oriented nMOSFETs is successfully demonstrated at scaled EOT region, while higher amount of available bonds on (1 1 0) surface results in a larger interface state density, leading to the degradation of sub-threshold slope. High breakdown voltages of 2.85 V and 2.9 V for (1 0 0)- and (1 1 0)-oriented nMOSFETs are considered to be due to superior interfacial property. The electron mobility on (1 1 0) orientation is lower than that on (1 0 0) orientation because of the smaller energy split between fourfold valleys and twofold valleys as well as the larger density of states for lower-energy valleys in the (1 1 0) surface. Moreover, electron mobility is reduced with decreasing EOT in both (1 0 0)- and (1 1 0)-oriented nMOSFETs. It is found that threshold voltage instability by positive bias stress is mainly responsible for bulk trapping of electron even with a larger interface state density in (1 1 0) orientation and influence of surface orientation on threshold voltage instability is negligibly small.

  14. Effect of non-solvent additives on the morphology, pore structure, and direct contact membrane distillation performance of PVDF-CTFE hydrophobic membranes.

    Science.gov (United States)

    Zheng, Libing; Wu, Zhenjun; Zhang, Yong; Wei, Yuansong; Wang, Jun

    2016-07-01

    Four common types of additives for polymer membrane preparation including organic macromolecule and micromolecule additives, inorganic salts and acids, and the strong non-solvent H2O were used to prepare poly (vinylidene fluoride-co-chlorotrifluoroethylene) (PVDF-CTFE) hydrophobic flat-sheet membranes. Membrane properties including morphology, porosity, hydrophobicity, pore size and pore distribution were investigated, and the permeability was evaluated via direct contact membrane distillation (DCMD) of 3.5g/L NaCl solution in a DCMD configuration. Both inorganic and organic micromolecule additives were found to slightly influence membrane hydrophobicity. Polyethylene glycol (PEG), organic acids, LiCl, MgCl2, and LiCl/H2O mixtures were proved to be effective additives to PVDF-CTFE membranes due to their pore-controlling effects and the capacity to improve the properties and performance of the resultant membranes. The occurrence of a pre-gelation process showed that when organic and inorganic micromolecules were added to PVDF-CTFE solution, the resultant membranes presented a high interconnectivity structure. The membrane prepared with dibutyl phthalate (DBP) showed a nonporous surface and symmetrical cross-section. When H2O and LiCl/H2O mixtures were also used as additives, they were beneficial for solid-liquid demixing, especially when LiCl/H2O mixed additives were used. The membrane prepared with 5% LiCl+2% H2O achieved a flux of 24.53kg/(m(2)·hr) with 99.98% salt rejection. This study is expected to offer a reference not only for PVDF-CTFE membrane preparation but also for other polymer membranes. PMID:27372116

  15. Advancing Scientific Reasoning in Upper Elementary Classrooms: Direct Instruction Versus Task Structuring

    NARCIS (Netherlands)

    Lazonder, A.W.; Wiskerke-Drost, Sjanou

    2015-01-01

    Several studies found that direct instruction and task structuring can effectively promote children’s ability to design unconfounded experiments. The present study examined whether the impact of these interventions extends to other scientific reasoning skills by comparing the inquiry activities of 5

  16. Objectification Theory and Psychology of Women: A Decade of Advances and Future Directions

    Science.gov (United States)

    Moradi, Bonnie; Huang, Yu-Ping

    2008-01-01

    Fredrickson and Roberts (1997) proposed objectification theory as an integrative framework for understanding how women's socialization and experiences of sexual objectification are translated into mental health problems. This article reviews the past decade of research grounded in objectification theory and highlights needed directions for future…

  17. Helpful Contacts

    Data.gov (United States)

    U.S. Department of Health & Human Services — The data used to populate the Helpful Contacts database is available for public usage. This functionality is primarily used by health policy researchers and the...

  18. Contact dermatitis

    Science.gov (United States)

    ... type. It can be by contact with acids, alkaline materials such as soaps and detergents , fabric softeners, ... dyes, and permanent wave solutions Nickel or other metals (found in jewelry, watch straps, metal zips, bra ...

  19. Contact problems

    CERN Document Server

    Galin, Lev Aleksandrovich

    2008-01-01

    L.A. Galin's book on contact problems is a remarkable work. Actually there are two books: the first, published in 1953 deals with contact problems in the classical theory of elasticity; this is the one that was translated into English in 1961. The second book, published in 1980, included the first, and then had new sections on contact problems for viscoelastic materials, and rough contact problems; this section has not previously been translated into English. In this new translation, the original text and the mathematical analysis have been completely revised, new material has been added, and the material appearing in the 1980 Russian translation has been completely rewritten. In addition there are three essays by students of Galin, bringing the analysis up to date.

  20. Direct evidence of lymphatic function improvement after advanced pneumatic compression device treatment of lymphedema

    OpenAIRE

    Adams, Kristen E.; Rasmussen, John C.; Darne, Chinmay; Tan, I-Chih; Aldrich, Melissa B.; Marshall, Milton V.; Fife, Caroline E.; Maus, Erik A.; Smith, Latisha A.; Guilloid, Renie; Hoy, Sunday; Sevick-Muraca, Eva M.

    2010-01-01

    Lymphedema affects up to 50% of all breast cancer survivors. Management with pneumatic compression devices (PCDs) is controversial, owing to the lack of methods to directly assess benefit. This pilot study employed an investigational, near-infrared (NIR) fluorescence imaging technique to evaluate lymphatic response to PCD therapy in normal control and breast cancer-related lymphedema (BCRL) subjects. Lymphatic propulsion rate, apparent lymph velocity, and lymphatic vessel recruitment were mea...

  1. Direct puncture embolization for the treatment of advanced juvenile nasopharyngeal angiofibroma

    International Nuclear Information System (INIS)

    Objective: To discuss the clinical application of direct puncture tumor embolization, which is used as a preoperative supplementary embolization,in treating juvenile nasopharyngeal angiofibroma (JNA). Methods: Twenty-nine patients were enrolled in this study. The shape and location of JNA were documented through the carotid angiography. Then, an 18-gauge needle was used to puncture the tumor. After the needle's position was confirmed to be in the right site and it was certain that no contrast leaked into the brain, 20-25% N-butyl-2-cyanoacrylate was slowly injected under fluoroscopic guidance until the entire JNA was fully filled with it. Results: Angiography revealed that the JNA received its blood supply from both the internal carotid artery and the external carotid artery in all 29 patients. After direct puncture tumor embolization the tumor stain became lessened and the distal end of the supplying arteries was not obviously displayed. Surgical resection was carried out within one week after embolization and the blood loss during the surgery was significantly reduced to 150-500 ml (mean 350 ml). Conclusion: Percutaneous direct puncture tumor embolization is a safe treatment for juvenile nasopharyngeal angiofibroma, it can effectively occlude the tumor's vessels and markedly reduce the blood loss during the surgery. (authors)

  2. Inapplicability of advance directives in a paternalistic setting: the case of a post-communist health system

    Directory of Open Access Journals (Sweden)

    Kruja Jera

    2011-06-01

    Full Text Available Abstract Background The Albanian medical system and Albanian health legislation have adopted a paternalistic position with regard to individual decision making. This reflects the practices of a not-so-remote past when state-run facilities and a totalitarian philosophy of medical care were politically imposed. Because of this history, advance directives concerning treatment refusal and do-not-resuscitate decisions are still extremely uncommon in Albania. Medical teams cannot abstain from intervening even when the patient explicitly and repeatedly solicits therapeutic abstinence. The Albanian law on health care has no provisions regarding limits or withdrawal of treatment. This restricts the individual's healthcare choices. Discussion The question of 'medically futile' interventions and pointless life-prolonging treatment has been discussed by several authors. Dutch physicians call such interventions 'medisch zinloos' (senseless, and the Netherlands, as one of the first states to legislate on end-of-life situations, actually regulates such issues through appropriate laws. In contrast, leaving an 'advance directive' is not a viable option for Albanian ailing individuals of advanced age. Verbal requests are provided during periods of mental competence, but unfortunately such instructions are rarely taken seriously, and none of them has ever been upheld in a legal or other official forum. Summary End-of-life decisions, treatment refusal and do-not-resuscitate policies are hazardous options in Albania, from the legal point of view. Complying with them involves significant risk on the part of the physician. Culturally, the application of such instructions is influenced from a mixture of religious beliefs, death coping-behaviors and an immense confusion concerning the role of proxies as decision-makers. Nevertheless, Albanian tradition is familiar with the notion of 'amanet', a sort of living will that mainly deals the property and inheritance issues

  3. A carbon dioxide partial condensation direct cycle for advanced gas cooled fast and thermal reactors

    International Nuclear Information System (INIS)

    A carbon dioxide partial condensation direct cycle concept has been proposed for gas cooled fast and thermal reactors. The fast reactor with the concept are evaluated to be a potential alternative option to liquid metal cooled fast reactors, providing comparable cycle efficiency at the same core outlet temperature, eliminating the safety problems, simplifying the heat transport system and making easier plant maintenance. The thermal reactor with the concept is expected to be an alternative solution to current high temperature gas cooled reactors (HTGRs) with helium gas turbines, allowing comparable cycle efficiency at the moderate temperature of 650 C instead of 800 C in HTGRs. (author)

  4. Human Identity Verification based on Heart Sounds: Recent Advances and Future Directions

    CERN Document Server

    Beritelli, Francesco

    2011-01-01

    Identity verification is an increasingly important process in our daily lives, and biometric recognition is a natural solution to the authentication problem. One of the most important research directions in the field of biometrics is the characterization of novel biometric traits that can be used in conjunction with other traits, to limit their shortcomings or to enhance their performance. The aim of this work is to introduce the reader to the usage of heart sounds for biometric recognition, describing the strengths and the weaknesses of this novel trait and analyzing in detail the methods developed so far by different research groups and their performance.

  5. Advanced Low Conductivity Thermal Barrier Coatings: Performance and Future Directions (Invited paper)

    Science.gov (United States)

    Zhu, Dongming; Miller, Robert A.

    2008-01-01

    Thermal barrier coatings will be more aggressively designed to protect gas turbine engine hot-section components in order to meet future engine higher fuel efficiency and lower emission goals. In this presentation, thermal barrier coating development considerations and performance will be emphasized. Advanced thermal barrier coatings have been developed using a multi-component defect clustering approach, and shown to have improved thermal stability and lower conductivity. The coating systems have been demonstrated for high temperature combustor applications. For thermal barrier coatings designed for turbine airfoil applications, further improved erosion and impact resistance are crucial for engine performance and durability. Erosion resistant thermal barrier coatings are being developed, with a current emphasis on the toughness improvements using a combined rare earth- and transition metal-oxide doping approach. The performance of the toughened thermal barrier coatings has been evaluated in burner rig and laser heat-flux rig simulated engine erosion and thermal gradient environments. The results have shown that the coating composition optimizations can effectively improve the erosion and impact resistance of the coating systems, while maintaining low thermal conductivity and cyclic durability. The erosion, impact and high heat-flux damage mechanisms of the thermal barrier coatings will also be described.

  6. Imaging-Genetics in Autism Spectrum Disorder: Advances, Translational Impact and Future Directions

    Directory of Open Access Journals (Sweden)

    StephanieH.Ameis

    2012-05-01

    Full Text Available Autism Spectrum Disorder (ASD refers to a group of heterogeneous neurodevelopmental disorders that are unified by impairments in reciprocal social communication and a pattern of inflexible behaviours. Recent genetic advances have resolved some of the complexity of the genetic architecture underlying ASD by identifying several genetic variants that contribute to the disorder. Different etiological pathways associated with ASD may converge through effects on common molecular mechanisms, such as synaptogenesis, neuronal motility, and axonal guidance. Recently, with more sophisticated techniques, neuroimaging and neuropathological studies have provided some consistency of evidence that altered structure, activity, and connectivity within complex neural networks is present in ASD, compared to typically developing children. The imaging-genetics approach promises to help bridge the gap between genetic variation, resultant biological effects on the brain, and production of complex neuropsychiatric symptoms. Here, we review recent findings from the developing field of imaging-genetics applied to ASD. Studies to date have indicated that relevant risk genes are associated with alterations in circuits that mediate socio-emotional, visuospatial and language processing. Longitudinal studies ideally focused on early development, in conjunction with investigation for gene-gene, and gene-environment interactions may move the promise of imaging-genetics in ASD closer to the clinical domain.

  7. Fairly direct hit. Advances in imaging of shotgun projectiles in MRI

    Energy Technology Data Exchange (ETDEWEB)

    Eggert, Sebastian [Kantonsspital Baden AG, Department of Radiology, Baden (Switzerland); University of Zurich, Institute of Forensic Medicine, Zurich (Switzerland); Kubik-Huch, Rahel A.; Peters, Alexander [Kantonsspital Baden AG, Department of Radiology, Baden (Switzerland); Klarhoefer, Markus [Siemens Healthcare, Zurich (Switzerland); Bolliger, Stephan A.; Thali, Michael J. [University of Zurich, Institute of Forensic Medicine, Zurich (Switzerland); Anderson, Suzanne [Kantonsspital Baden AG, Department of Radiology, Baden (Switzerland); University of Notre Dame Australia, Radiology, Sydney School of Medicine, Sydney, NSW (Australia); Froehlich, Johannes M. [Federal Institute of Technology, Pharmaceutical Sciences, Zurich (Switzerland)

    2015-09-15

    To investigate the magnetic properties of different types of projectiles and qualify the metal artefact reduction technique for diagnostic and/or forensic MRI. Ten different projectiles embedded in ordnance gelatine blocks underwent an in vitro 1.5-T MR study with seven sequences including a recently developed metal artefact reduction sequence (Advanced WARP) combining VAT (view-angle-tilting) and SEMAC (slice-encoding metal-artefact-correction). Resulting image quality (five-point scale: 1=best; 5=worst) was scored. Quantifiable magnetic characteristics were correlated with qualitative rating of the MR sequences and torque dislodgment. Metal artefact reduction sequence (median: 2.5) significantly (p < 0.001) improves depiction of projectiles in comparison to all other MR pulse sequences (median: 4.75). Images from diamagnetic composed bullets (median: 2) are much less disturbed compared to magnetic attracted ones (median: 5). Correlation (0.623) between deflection angle measurement (ferromagnetic mean 84.2 ; paramagnetic 62 ; diamagnetic mean 0 ) and median qualitative image quality was highly significant (p = 0.027). Torque dislodgement was distinct for elongated magnetic attracted projectiles. Significant improvement of MR imaging of projectiles using metal artefact reduction techniques has important implications for diagnostic/forensic work-up. The correlations between magnetic attraction force, deflection-angle results and image properties demonstrate that the MR safety of projectiles can be estimated with one of these methods. (orig.)

  8. Fairly direct hit. Advances in imaging of shotgun projectiles in MRI

    International Nuclear Information System (INIS)

    To investigate the magnetic properties of different types of projectiles and qualify the metal artefact reduction technique for diagnostic and/or forensic MRI. Ten different projectiles embedded in ordnance gelatine blocks underwent an in vitro 1.5-T MR study with seven sequences including a recently developed metal artefact reduction sequence (Advanced WARP) combining VAT (view-angle-tilting) and SEMAC (slice-encoding metal-artefact-correction). Resulting image quality (five-point scale: 1=best; 5=worst) was scored. Quantifiable magnetic characteristics were correlated with qualitative rating of the MR sequences and torque dislodgment. Metal artefact reduction sequence (median: 2.5) significantly (p < 0.001) improves depiction of projectiles in comparison to all other MR pulse sequences (median: 4.75). Images from diamagnetic composed bullets (median: 2) are much less disturbed compared to magnetic attracted ones (median: 5). Correlation (0.623) between deflection angle measurement (ferromagnetic mean 84.2 ; paramagnetic 62 ; diamagnetic mean 0 ) and median qualitative image quality was highly significant (p = 0.027). Torque dislodgement was distinct for elongated magnetic attracted projectiles. Significant improvement of MR imaging of projectiles using metal artefact reduction techniques has important implications for diagnostic/forensic work-up. The correlations between magnetic attraction force, deflection-angle results and image properties demonstrate that the MR safety of projectiles can be estimated with one of these methods. (orig.)

  9. Development of advanced direct perception displays for nuclear power plants to enhance monitoring, control and fault management

    International Nuclear Information System (INIS)

    With recent theoretical and empirical research in basic and applied psychology, human factors, and engineering, it is now sufficient to define an integrated approach to the deign of advanced displays for present and future nuclear power plants. Traditionally, the conventional displays have shown operators the individual variables on gauges, meters, strip charts, etc. This design approach requires the operators to mentally integrate the separately displayed variables and determine the implications for the plant state. This traditional approach has been known as the single-sensor-single-indicator display design and it places an intolerable amount of mental workload on operators during transients and abnormal conditions. This report discusses a new alternative approach which is the use of direct perception interfaces. Direct perception a interfaces display the underlying physical and system constraints of the situation in a directly perceptual way, such that the viewer need not reason about what is seen to identify system states, but can identify the state of the system perceptually. It is expected that displays which show the dynamics of fundamental physical laws should better support operator decisions and diagnoses of plant states. The purpose of this research project is to develop a suite of direct perception displays for PWR nuclear power plant operations

  10. Direct-contact condensation heat transfer with noncondensable gases and interfacial shear for co-current stratified wavy flow in nearly-horizontal channels

    International Nuclear Information System (INIS)

    channel data group (0.7 .deg. ≤ θ ≤10 .deg. ). Experimental observations show that the super-critical flow only exists in the channel for the inclined channel data group while the water level gradient and hydraulic jump do for the nearly horizontal data group. For the inclined channel data group, a dimensionless wave height, Δh/h, is empirically correlated in terms of ReG and h/H. A modified root-mean-square wave height is proposed to consider the effects of the interfacial and wave propagation velocities. It is found that an equivalent roughness has a linear relationship with the modified root-mean-square wave height. Direct-contact condensation experiments of atmospheric steam and steam/air mixture on subcooled water flowing co-currently in nearly horizontal channels are carried out and the logarithmic and local heat transfer coefficients are obtained. In the case of pure steam, the heat transfer coefficient increases as an increase in the inlet steam flow rate and inclination. The heat transfer coefficient due to the increased inlet water flow rate is slightly increased. In the presence of noncondensable gas, the heat transfer coefficient is much reduced as an increase in the inlet air mass fraction. The heat transfer coefficient increases as an increase in the inlet mixture flow rate. However, it decreases as an increase in the inlet water flow rate due to the change of the heat transfer mechanism from water layer to the mixture layer. The local heat transfer coefficient is enhanced in the large amplitude region even though the noncondensable gas exists. The heat transfer resistance also depends on the water side for the large amplitude region. For all cases it is found that the heat transfer coefficient increases as an increase in inclination. Direct-contact condensation database is constructed. Assessment and improvement of the direct-condensation model in RELAP5/MOD3.2 are performed. The horizontally stratified condensation model of RELAP5/MOD3.2 overpredicts

  11. On recent advances and future research directions for computational fluid dynamics

    Science.gov (United States)

    Baker, A. J.; Soliman, M. O.; Manhardt, P. D.

    1986-01-01

    This paper highlights some recent accomplishments regarding CFD numerical algorithm constructions for generation of discrete approximate solutions to classes of Reynolds-averaged Navier-Stokes equations. Following an overview of turbulent closure modeling, and development of appropriate conservation law systems, a Taylor weak-statement semi-discrete approximate solution algorithm is developed. Various forms for completion to the final linear algebra statement are cited, as are a range of candidate numerical linear algebra solution procedures. This development sequence emphasizes the key building blocks of a CFD RNS algorithm, including solution trial and test spaces, integration procedure and added numerical stability mechanisms. A range of numerical results are discussed focusing on key topics guiding future research directions.

  12. MOTHER MK II: An advanced direct cycle high temperature gas reactor

    International Nuclear Information System (INIS)

    The MOTHER (MOdular Thermal HElium Reactor) power plant concepts employ high temperature gas reactors utilizing TRISO fuel, graphite moderator, and helium coolant, in combination with a direct Brayton cycle for electricity generation. The helium coolant from the reactor vessel passes through a Power Conversion Unit (PCU), which includes a turbine-generator, recuperator, precooler, intercooler and turbine-compressors, before being returned to the reactor vessel. The PCU substitutes for the reactor coolant system pumps and steam generators and most of the Balance Of Plant (BOP), including the steam turbines and condensers, employed by conventional nuclear power plants utilizing water cooled reactors. This provides a compact, efficient, and relatively simple plant configuration. The MOTHER MK I conceptual design, completed in the 1987 - 1989 time frame, was developed to economically meet the energy demands for extracting and processing heavy oil from the tar sands of western Canada. However, considerable effort was made to maximize the market potential beyond this application. Consistent with the remote and very high labour rate environment in the tar sands region, simplification of maintenance procedures and facilitation of 'change-out' in lieu of in situ repair was a design focus. MOTHER MK I had a thermal output of 288 MW and produced 120 MW electrical when operated in the electricity only production mode. An annular Prismatic reactor core was utilized, largely to minimize day-to-day operations activities. Key features of the power conversion system included two Power Conversion Units (144 MWth each), the horizontal orientation of all rotating machinery and major heat exchangers axes, high speed rotating machinery (17,030 rpm for the turbine-compressors and 10,200 rpm for the power turbine-generator), gas (helium) bearings for all rotating machinery, and solid state frequency conversion from 170 cps (at full power) to the grid frequency. Recognizing that the on

  13. Advancing predictive models for particulate formation in turbulent flames via massively parallel direct numerical simulations

    KAUST Repository

    Bisetti, Fabrizio

    2014-07-14

    Combustion of fossil fuels is likely to continue for the near future due to the growing trends in energy consumption worldwide. The increase in efficiency and the reduction of pollutant emissions from combustion devices are pivotal to achieving meaningful levels of carbon abatement as part of the ongoing climate change efforts. Computational fluid dynamics featuring adequate combustion models will play an increasingly important role in the design of more efficient and cleaner industrial burners, internal combustion engines, and combustors for stationary power generation and aircraft propulsion. Today, turbulent combustion modelling is hindered severely by the lack of data that are accurate and sufficiently complete to assess and remedy model deficiencies effectively. In particular, the formation of pollutants is a complex, nonlinear and multi-scale process characterized by the interaction of molecular and turbulent mixing with a multitude of chemical reactions with disparate time scales. The use of direct numerical simulation (DNS) featuring a state of the art description of the underlying chemistry and physical processes has contributed greatly to combustion model development in recent years. In this paper, the analysis of the intricate evolution of soot formation in turbulent flames demonstrates how DNS databases are used to illuminate relevant physico-chemical mechanisms and to identify modelling needs. © 2014 The Author(s) Published by the Royal Society.

  14. Advancing predictive models for particulate formation in turbulent flames via massively parallel direct numerical simulations.

    Science.gov (United States)

    Bisetti, Fabrizio; Attili, Antonio; Pitsch, Heinz

    2014-08-13

    Combustion of fossil fuels is likely to continue for the near future due to the growing trends in energy consumption worldwide. The increase in efficiency and the reduction of pollutant emissions from combustion devices are pivotal to achieving meaningful levels of carbon abatement as part of the ongoing climate change efforts. Computational fluid dynamics featuring adequate combustion models will play an increasingly important role in the design of more efficient and cleaner industrial burners, internal combustion engines, and combustors for stationary power generation and aircraft propulsion. Today, turbulent combustion modelling is hindered severely by the lack of data that are accurate and sufficiently complete to assess and remedy model deficiencies effectively. In particular, the formation of pollutants is a complex, nonlinear and multi-scale process characterized by the interaction of molecular and turbulent mixing with a multitude of chemical reactions with disparate time scales. The use of direct numerical simulation (DNS) featuring a state of the art description of the underlying chemistry and physical processes has contributed greatly to combustion model development in recent years. In this paper, the analysis of the intricate evolution of soot formation in turbulent flames demonstrates how DNS databases are used to illuminate relevant physico-chemical mechanisms and to identify modelling needs. PMID:25024412

  15. Advances of direct drive schemes in laser fusion research at ILE Osaka

    International Nuclear Information System (INIS)

    ILE Osaka is concentrating on the physical elements of fast ignition aiming at the proof of principle for ignition-and-burn of direct-drive laser fusion. A 1PW laser will be introduced to fast ignition experiments by the middle of 2001. A high intensity plasma experimental research system, HIPER, has been in operation for obtaining scientific data base relevant to ignition target. By irradiating a intense short pulse onto a long scale length plasma observed are penetration of a relativistically self-focused laser beam into over-dense region without considerable energy loss in under-dense region, MeV electrons generation with conversion efficiency of 25%, heating of compressed core plasma by irradiating a 100 ps, 1017W/cm2 pulse and 1 ps, 1019W/cm2 pulse. In the hydrodynamic instability, the initial imprint of hydrodynamic instability and Rayleigh-Taylor growth rate at wavelength less than 10 μm have been investigated extensively. (author)

  16. Direct observation of macro-layer for advanced understanding of critical heat flux mechanism

    International Nuclear Information System (INIS)

    Full text of publication follows: Water and R134a boiling phenomena have investigated in the subcooled flow boiling. The results emphasize that the behavior of a liquid layer near the boiling surface plays the most important role in occurring boiling crisis. However, actually its dynamic behavior could not be investigated due to very fast and complex near-wall phenomena. Therefore, it is considered that an investigation in rather slower phenomena can provide the dynamic behavior of the liquid layer or its actual existence. Therefore, pool boiling experiment was tried to observe it. In vertical pool boiling, a thin liquid film adhering to a heater surface was directly observed underneath a massive vapor bubble. Its repeated life cycle continues with the periodic formation of a large vapor bubble. The liquid film of this structure plays a significant role on a heat transfer process. The liquid film results from internally trapping by means of both lateral and vertical coalescence of nucleate bubbles and externally supplying with spreading. The film consists of three parts such as liquid wetting area, dry spots, nucleating bubbles in charge of heat transfer from the heater surface during the growth period of a vapor bubble. Dryout proceeds with evaporation of the film starting from centers of some dry spots. Boiling crisis occurs by means of no wetting with interfering liquid resupply due to increase of wall temperature of repeated dryout. (authors)

  17. Advance care directives and the position in Ireland: what lessons can Ireland learn from the United Kingdom, the United States and Europe?

    OpenAIRE

    Laura Donnellan

    2008-01-01

    An Advance care directive entitles a person to request in advance either the refusal of or consent to certain medical treatment if that person is not competent to consent or refuse at the time such refusal or consent is required.  The 2003 Law Reform Commission’s Consultation Paper on Law and the Elderly briefly mentioned advance directives.  However, the Paper decided to leave the issue to a future Paper that would give a more comprehensive analysis.  There is no Irish legislation on the mat...

  18. Contact Dermatitis

    Science.gov (United States)

    ... resources Meet our partners Español Donate Diseases and treatments Acne and rosacea Bumps and growths Color problems Contagious skin diseases ... Contact dermatitis public SPOT Skin Cancer™ Diseases and treatments Acne and rosacea Bumps and growths Color problems Contagious skin diseases ...

  19. ADVANCED BYPRODUCT RECOVERY: DIRECT CATALYTIC REDUCTION OF SO2 TO ELEMENTAL SULFUR

    Energy Technology Data Exchange (ETDEWEB)

    Robert S. Weber

    1999-05-01

    Arthur D. Little, Inc., together with its commercialization partner, Engelhard Corporation, and its university partner Tufts, investigated a single-step process for direct, catalytic reduction of sulfur dioxide from regenerable flue gas desulfurization processes to the more valuable elemental sulfur by-product. This development built on recently demonstrated SO{sub 2}-reduction catalyst performance at Tufts University on a DOE-sponsored program and is, in principle, applicable to processing of regenerator off-gases from all regenerable SO{sub 2}-control processes. In this program, laboratory-scale catalyst optimization work at Tufts was combined with supported catalyst formulation work at Engelhard, bench-scale supported catalyst testing at Arthur D. Little and market assessments, also by Arthur D. Little. Objectives included identification and performance evaluation of a catalyst which is robust and flexible with regard to choice of reducing gas. The catalyst formulation was improved significantly over the course of this work owing to the identification of a number of underlying phenomena that tended to reduce catalyst selectivity. The most promising catalysts discovered in the bench-scale tests at Tufts were transformed into monolith-supported catalysts at Engelhard. These catalyst samples were tested at larger scale at Arthur D. Little, where the laboratory-scale results were confirmed, namely that the catalysts do effectively reduce sulfur dioxide to elemental sulfur when operated under appropriate levels of conversion and in conditions that do not contain too much water or hydrogen. Ways to overcome those limitations were suggested by the laboratory results. Nonetheless, at the end of Phase I, the catalysts did not exhibit the very stringent levels of activity or selectivity that would have permitted ready scale-up to pilot or commercial operation. Therefore, we chose not to pursue Phase II of this work which would have included further bench-scale testing

  20. Advance Care Directives and the Position in Ireland: What lessons can Ireland learn from the United Kingdom, the United States and Europe?

    Directory of Open Access Journals (Sweden)

    Laura Donnellan

    2007-12-01

    Full Text Available An Advance care directive entitles a person to request in advance either the refusal of or consent to certain medical treatment if that person is not competent to consent or refuse at the time such refusal or consent is required.  The 2003 Law Reform Commission’s Consultation Paper on Law and the Elderly briefly mentioned advance directives.  However, the Paper decided to leave the issue to a future Paper that would give a more comprehensive analysis.  There is no Irish legislation on the matter and consequently the legal position is unclear.  The English Mental Capacity Act 2005 has given recognition to advance directives under section 24.  It is interesting to note that only refusal is covered by the Act.  The 2005 Law Reform Commission Consultation Paper on Vulnerable Adults discusses the issue of advance directives in more detail.  This Paper will examine the Irish position of advance directives.  The British Mental Capacity Act and recent case law will provide a comparative analysis.  The UN Convention on the Protection of the Rights and Dignity of Persons with Disabilities will also be examined.

  1. Proceedings of the advanced research and technology development direct utilization, instrumentation and diagnostics contractors' review meeting

    Energy Technology Data Exchange (ETDEWEB)

    Geiling, D.W. (USDOE Morgantown Energy Technology Center, WV (USA)); Goldberg, P.M. (eds.) (USDOE Pittsburgh Energy Technology Center, PA (USA))

    1990-01-01

    The 1990 Advanced Research and Technology Development (AR TD) Direct Utilization, and Instrumentation and Diagnostics Contractors Review Meeting was held September 16--18, 1990, at the Hyatt at Chatham Center in Pittsburgh, PA. The meeting was sponsored by the US Department of Energy (DOE), Office of Fossil Energy, and the Pittsburgh and Morgantown Energy Technology Centers. Each year the meeting provides a forum for the exchange of information among the DOE AR TD contractors and interested parties. This year's meeting was hosted by the Pittsburgh Energy Technology Center and was attended by 120 individuals from industry, academia, national laboratories, and other governmental agencies. Papers were presented on research addressing coal surface, science, devolatilization and combustion, ash behavior, emission controls for gases particulates, fluid bed combustion and utilization in diesels and turbines. Individual reports are processed separately for the data bases.

  2. Advanced direct liquefaction concepts for PETC generic units, Phase 2. Quarterly technical progress report, January--March 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-05-01

    The aims of this research program are to advance to bench-scale testing, concepts that have the potential for making net reductions in direct coal liquefaction process costs. The research involves a teaming arrangement between the University of Kentucky Center for Applied Energy Research (CAER), Consolidation Coal Company (CONSOL), Sandia National Laboratories (SNL), and LDP Associates. Progress reports are presented for: Task 2.1.1 development of a catalyst screening test (UK/CAER); Task 2.1.2 activation of impregnated catalysts (UK/CAER); Task 2.2 laboratory support (CONSOL); Task 3 continuous operations/parametric studies (Hydrocarbon Technologies, Inc.) and; Task 4.4 conceptual design, preliminary technical assessment (LDP Associates).

  3. Do Spanish Hospital Professionals Educate Their Patients About Advance Directives? : A Descriptive Study in a University Hospital in Madrid, Spain.

    Science.gov (United States)

    Pérez, María; Herreros, Benjamín; Martín, M Dolores; Molina, Julia; Kanouzi, Jack; Velasco, María

    2016-06-01

    It is unknown whether hospital-based medical professionals in Spain educate patients about advance directives (ADs). The objective of this research was to determine the frequency of hospital-based physicians' and nurses' engagement in AD discussions in the hospital and which patient populations merit such efforts. A short question-and-answer-based survey of physicians and nurses taking care of inpatients was conducted at a university hospital in Madrid, Spain. In total, 283 surveys were collected from medical professionals, of whom 71 per cent were female, with an average age of thirty-four years. Eighty-four per cent had never educated patients about ADs because of lack of perceived responsibility, time, or general knowledge of ADs. Patient populations that warranted AD discussions included those with terminal illnesses (77 per cent), chronic diseases (61 per cent), and elderly patients (43 per cent). Regarding degree of AD understanding in medical professionals: 57 per cent of medical professionals claimed sufficient general knowledge of ADs, 19 per cent understood particulars regarding AD document creation, and 16 per cent were aware of AD regulatory policies. Engagement in AD discussions was considered important by 83 per cent of medical professionals, with 79 per cent interested in participating in such discussions themselves. The majority of hospital physicians and nurses do not educate their patients about ADs, despite acknowledging their importance. Patient populations of highest priority included those with terminal diseases or chronic illness or who are of advanced age. PMID:26797513

  4. Scientific Opinion on the safety assessment of the process LPR based on EREMA Advanced and Colortronic SSP ® technology used to recycle post-consumer PET into food contact materials

    OpenAIRE

    EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF)

    2014-01-01

    This scientific opinion of the EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids deals with the safety assessment of the recycling process LPR (EU register No RECYC061) which is based on the EREMA advanced and Colortronic SSP ® technologies. The input to the process is hot caustic washed and dried PET flakes originating from collected post-consumer PET bottles and containing no more than 5 % of PET from non-food consumer applications. In this process, washed and d...

  5. CD8+ but not CD4+ T cells require cognate interactions with target tissues to mediate GVHD across only minor H antigens, whereas both CD4+ and CD8+ T cells require direct leukemic contact to mediate GVL

    OpenAIRE

    Matte-Martone, Catherine; Liu, Jinli; Jain, Dhanpat; McNiff, Jennifer; Shlomchik, Warren D.

    2008-01-01

    Whether T-cell antigen receptors (TCR) on donor T cells require direct interactions with major histocompatibility complex class I or class II (MHCI/MHCII) molecules on target cells to mediate graft-versus-host disease (GVHD) and graft-versus-leukemia (GVL) is a fundamental question in allogeneic stem-cell transplantation (alloSCT). In MHC-mismatched mouse models, these contacts were not required for GVHD. However, this conclusion may not apply to MHC-matched, multiple minor histocompatibility...

  6. Understanding contact angle hysteresis on an ambient solid surface

    Science.gov (United States)

    Wang, Yong Jian; Guo, Shuo; Chen, Hsuan-Yi; Tong, Penger

    2016-05-01

    We report a systematic study of contact angle hysteresis (CAH) with direct measurement of the capillary force acting on a contact line formed on the surface of a long glass fiber intersecting a liquid-air interface. The glass fiber of diameter 1 -2 μ m and length 100 -200 μ m is glued onto the front end of a rectangular cantilever beam, which is used for atomic force microscopy. From the measured hysteresis loop of the capillary force for 28 different liquids with varying surface tensions and contact angles, we find a universal behavior of the unbalanced capillary force in the advancing and receding directions and the spring constant of a stretched meniscus by the glass fiber. Measurements of the capillary force and its fluctuations suggest that CAH on an ambient solid surface is caused primarily by two types of coexisting and spatially intertwined defects with opposite natures. The contact line is primarily pinned by the relatively nonwetting (repulsive) defects in the advancing direction and by the relatively wetting (attractive) defects in the receding direction. Based on the experimental observations, we propose a "composite model" of CAH and relevant scaling laws, which explain the basic features of the measured hysteresis force loops.

  7. Advanced direct liquefaction concepts for PETC generic units: Phase 2. Quarterly technical progress report, July--September, 1996

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1996-11-01

    The Advanced Direct Liquefaction Concepts Program sponsored by the DOE Pittsburgh Energy Technology Center was initiated in 1991 with the objective of promoting the development of new and emerging technology that has the potential for reducing the cost of producing liquid fuels by direct coal liquefaction. The laboratory research program (Phase I) was completed in 1995 by UK/CAER, CONSOL, Sandia National Laboratories and LDP Associates. A three year extension was subsequently awarded in October 1995 to further develop several promising concepts derived from the laboratory program. During Phase II, four continuous bench scale runs will be conducted at Hydrocarbon Technologies, Inc. using a 2 kg/hr continuous bench scale unit located at their facility in Lawrenceville, NJ. The first run in this program (ALC-1), conducted between April 19 and May 14, 1996, consisted of five test conditions to evaluate the affect of coal cleaning and recycle solvent modification. A detailed discussion of this run is included in Section Two of this report. Results obtained during this reporting period for all participants in this program are summarized.

  8. Directional Advanced Intruder Handling Ad-hoc on Demand Distance Vector Protocol Using Divide and Conquer Strategy Implementation

    Directory of Open Access Journals (Sweden)

    S. Hemalatha

    2015-03-01

    Full Text Available The Aim of this study is to develop the protocol for identify the failure node, intruder node with power optimized routing protocol named Directional Advanced Intruder Handling Adhoc On demand Vector protocol. Mobile Ad-hoc Network is an infrastructure less network, nodes in mobile Ad-hoc are comprised to work with wireless nodes, can move freely and dynamically self organized in to arbitrary topologies. Over the past twenty years the development of Ad-hoc network was developed from tactical networks to Bluetooth, HyperLAN and IEEE 802.11. In the protocol stack of Ad-hoc network, the major issues on network layers, which has a responsibility to transfer the packets from one node to another. Many protocols have been proposed in Ad-hoc network, but none of the protocol is working under the principle of handling checking on packet delivery. This study presents the Directional Advanced Intruder Handling Ad-hoc on demand Vector protocol algorithm definition and implementation. The working principle of this protocol is checking the packet delivery to the destination. If any one of the nodes in the route is not forwarding the packet, that corresponding node will be identified and redirect the packet to the new route. For doing this checking this protocol uses divide and conquer strategy. The number hop between the source to destination is divided into two halves and check whether the up to the middle node the packet are flowing in a proper order or not. Recursively doing the divide and conquer of the route path, can identify the node which is not forward the packet to the next node. The design of this protocol itself able to identify the intruder in the routing path. Contains several stages from path discovery, packet transmits, apply divide and conquer strategy on route, identify the node which is not forward the packet, redirect the new path, alert all the nodes about the victim node. Finally performance of the protocol is improved with transmission

  9. Advanced Parkinson’s disease effect on goal-directed and habitual processes involved in visuomotor associative learning

    Directory of Open Access Journals (Sweden)

    Fadila eHadj-Bouziane

    2013-01-01

    Full Text Available The present behavioral study readdresses the question of habit learning in Parkinson's disease. Patients were early onset, non-demented, dopa-responsive, candidates for surgical treatment, similar to those we found earlier as suffering greater dopamine depletion in the putamen than in the caudate nucleus. The task was the same conditional associative learning task as that used previously in monkeys and healthy humans to unveil the striatum involvement in habit learning. Sixteen patients and 20 age- and education-matched healthy control subjects learned sets of 3 visuo-motor associations between complex patterns and joystick displacements during two testing sessions separated by a few hours. We distinguished errors preceding versus following the first correct response to compare patients' performance during the earliest phase of learning dominated by goal-directed actions with that observed later on, when responses start to become habitual. The disease significantly retarded both learning phases, especially in patients under sixty years of age. However, only the late phase deficit was disease severity-dependent and persisted on the second testing session. These findings provide the first corroboration in Parkinson patients of two ideas well-established in the animal literature. The first is the idea that associating visual stimuli to motor acts is a form of habit learning that engages the striatum. It is confirmed here by the global impairment in visuo-motor learning induced by Parkinson's disease. The second idea is that goal-directed behaviors are predominantly caudate-dependent whereas habitual responses are primarily putamen-dependent. At the advanced Parkinson's disease stages tested here, dopamine depletion is greater in the putamen than in the caudate nucleus. Accordingly, the late phase of learning corresponding to the emergence of habitual responses was more vulnerable to the disease than the early phase dominated by goal-directed

  10. Mechanical Contact Experiments and Simulations

    DEFF Research Database (Denmark)

    Nielsen, Chris Valentin; Martins, P; Zhang, W.; Bay, Niels

    geometries and different materials are analyzed including contact between dissimilar materials. The numerical implementation is performed with a finite element computer program based on the irreducible flow formulation, and contact between deformable objects is modelled by applying the penalty method. The......Mechanical contact is studied under dynamic development by means of a combined numerical and experimental investigation. The experiments are designed to allow dynamical development of non-planar contact areas with significant expansion in all three directions as the load is increased. Different...... overall investigation serves for testing and validating the numerical implementation of the mechanical contact, which is one of the main contributions to a system intended for 3D simulation of resistance welding. Correct modelling of contact between parts to be welded, as well as contact with electrodes...

  11. Advance care directives

    Science.gov (United States)

    ... order on your medical chart. Fill out an organ donation card and carry it in your wallet. Keep ... your important papers. You can find out about organ donation from your doctor. You can also have this ...

  12. Direct contact between dendritic cells and bronchial epithelial cells inhibits T cell recall responses towards mite and pollen allergen extracts in vitro

    DEFF Research Database (Denmark)

    Papazian, Dick; Wagtmann, Valery R; Hansen, Soren;

    2015-01-01

    (DCs), we have investigated recall T cell responses in allergic patients sensitized to house dust mite, grass, and birch pollen. Conclusions: Using allergen extract-loaded DCs to stimulate autologous allergen-specific T cell lines, we show that AEC-imprinted DCs inhibit T cell proliferation...... cell recall responses towards Bet v 1, Phl p 5 and Der p 1 in vitro, suggesting that AECs-DC contact in vivo constitute a key element in mucosal homeostasis. This article is protected by copyright. All rights reserved....

  13. La perspectiva de las personas mayores sobre el testamento vital Elders´perspective about Advance Directives

    Directory of Open Access Journals (Sweden)

    Inés Mª Barrio Cantalejo

    2006-06-01

    Full Text Available Antecedentes. La popularización del testamento vital (TV exige conocer la perspectiva que sobre él tienen sus potenciales usuarios. Cualquier intento de generalizar el TV sin evaluar cómo será recibido por las personas mayores está condenado al fracaso. Objetivo: Explorar la perspectiva de los mayores sobre el testamento vital. Diseño: Estudio cualitativo. 40 personas mayores, usuarios de 3 Centros de Salud y 1 Residencia Asistida de Madrid, se reunieron en 5 grupos de discusión en abril de 2004. Participantes: 14 mediadores captaron a 2-3 participantes cada uno. Se consideró que edad y residencia en medio familiar o institucional son las variables que más diferencian la elaboración de los discursos sobre el TV. Se utilizaron, pues, como criterios de segmentación, buscando heterogeneidad entre grupos y homogeneidad y heterogeneidad intragrupal. La saturación se consideró cuando las ideas expresadas resultaron recurrentes. Resultados: 4 ideas se extraen de los datos: 1 los mayores prefieren la planificación anticipada de decisiones al TV. 2 Su opinión sobre el TV se asocia a la vivencia singular de otros eventos en el final de la vida. 3 Conceden un papel relevante a la familia. 4 Desean conducir su propia vida, pero "sin papeles escritos". Conclusiones. La implementación del TV a través de una estrategia educativa e institucional se beneficiará si consideramos la perspectiva de la población mayor española sobre el TV.Background: The introduction of advance directives (AD require to examine the perspective their potential users have about. Any public policy about the implementation of ADs adressed to elders will fall if their perspective is unknown. Objective: To examine the elders' perspective about advance directives. Methods: Qualitative study. 40 elders, users of 3 Primary Health Care Center, and of 1 Nursing Home from Madrid. 5 focus groups were organized in 2004 April. Participants: 14 providers recruited 2

  14. Non-CAR resists and advanced materials for Massively Parallel E-Beam Direct Write process integration

    Science.gov (United States)

    Pourteau, Marie-Line; Servin, Isabelle; Lepinay, Kévin; Essomba, Cyrille; Dal'Zotto, Bernard; Pradelles, Jonathan; Lattard, Ludovic; Brandt, Pieter; Wieland, Marco

    2016-03-01

    The emerging Massively Parallel-Electron Beam Direct Write (MP-EBDW) is an attractive high resolution high throughput lithography technology. As previously shown, Chemically Amplified Resists (CARs) meet process/integration specifications in terms of dose-to-size, resolution, contrast, and energy latitude. However, they are still limited by their line width roughness. To overcome this issue, we tested an alternative advanced non-CAR and showed it brings a substantial gain in sensitivity compared to CAR. We also implemented and assessed in-line post-lithographic treatments for roughness mitigation. For outgassing-reduction purpose, a top-coat layer is added to the total process stack. A new generation top-coat was tested and showed improved printing performances compared to the previous product, especially avoiding dark erosion: SEM cross-section showed a straight pattern profile. A spin-coatable charge dissipation layer based on conductive polyaniline has also been tested for conductivity and lithographic performances, and compatibility experiments revealed that the underlying resist type has to be carefully chosen when using this product. Finally, the Process Of Reference (POR) trilayer stack defined for 5 kV multi-e-beam lithography was successfully etched with well opened and straight patterns, and no lithography-etch bias.

  15. Thermal contact conductance

    CERN Document Server

    Madhusudana, Chakravarti V

    2013-01-01

    The work covers both theoretical and practical aspects of thermal contact conductance. The theoretical discussion focuses on heat transfer through spots, joints, and surfaces, as well as the role of interstitial materials (both planned and inadvertent). The practical discussion includes formulae and data that can be used in designing heat-transfer equipment for a variety of joints, including special geometries and configurations. All of the material has been updated to reflect the latest advances in the field.

  16. Advance Health Care Directives and “Public Guardian”: The Italian Supreme Court Requests the Status of Current and Not Future Inability

    Directory of Open Access Journals (Sweden)

    Francesco Paolo Busardò

    2014-01-01

    Full Text Available Advance health care decisions animate an intense debate in several European countries, which started more than 20 years ago in the USA and led to the adoption of different rules, based on the diverse legal, sociocultural and philosophical traditions of each society. In Italy, the controversial issue of advance directives and end of life’s rights, in the absence of a clear and comprehensive legislation, has been over time a subject of interest of the Supreme Court. Since 2004 a law introduced the “Public Guardian,” aiming to provide an instrument of assistance to the person lacking in autonomy because of an illness or incapacity. Recently, this critical issue has once again been brought to the interest of the Supreme Court, which passed a judgment trying to clarify the legislative application of the appointment of the Guardian in the field of advance directives.

  17. Nurses' knowledge of advance directives and perceived confidence in end-of-life care: a cross-sectional study in five countries.

    LENUS (Irish Health Repository)

    Coffey, Alice

    2016-01-28

    Nurses\\' knowledge regarding advance directives may affect their administration and completion in end-of-life care. Confidence among nurses is a barrier to the provision of quality end-of-life care. This study investigated nurses\\' knowledge of advance directives and perceived confidence in end-of-life care, in Hong Kong, Ireland, Israel, Italy and the USA using a cross-sectional descriptive design (n = 1089). In all countries, older nurses and those who had more professional experience felt more confident managing patients\\' symptoms at end-of-life and more comfortable stopping preventive medications at end-of-life. Nurses in the USA reported that they have more knowledge and experience of advance directives compared with other countries. In addition, they reported the highest levels of confidence and comfort in dealing with end-of-life care. Although legislation for advance directives does not yet exist in Ireland, nurses reported high levels of confidence in end-of-life care.

  18. Contribution of Morphological Awareness and Lexical Inferencing Ability to L2 Vocabulary Knowledge and Reading Comprehension among Advanced EFL Learners: Testing Direct and Indirect Effects

    Science.gov (United States)

    Zhang, Dongbo; Koda, Keiko

    2012-01-01

    Within the Structural Equation Modeling framework, this study tested the direct and indirect effects of morphological awareness and lexical inferencing ability on L2 vocabulary knowledge and reading comprehension among advanced Chinese EFL readers in a university in China. Using both regular z-test and the bootstrapping (data-based resampling)…

  19. Hydrogen production with short contact time. Catalytic partial oxidation of hydrocarbons and oxygenated compounds: Recent advances in pilot- and bench-scale testing and process design

    Energy Technology Data Exchange (ETDEWEB)

    Guarinoni, A.; Ponzo, R.; Basini, L. [ENI Refining and Marketing Div., San Donato Milanese (Italy)

    2010-12-30

    ENI R and D has been active for fifteen years in the development of Short Contact Time - Catalytic Partial Oxidation (SCT-CPO) technologies for producing Hydrogen/Synthesis Gas. From the beginning the experimental work addressed either at defining the fundamental principles or the technical and economical potential of the technology. Good experimental responses, technical solutions' simplicity and flexibility, favourable techno-economical evaluations promoted the progressive widening of the field of the investigations. From Natural Gas (NG) the range of ''processable'' Hydrocarbons extended to Liquefied Petroleum Gas (LPG) and Gasoils, including those characterised by high levels of unsaturated and sulphurated molecules and, lately, to other compounds with biological origin. The extensive work led to the definition of different technological solutions, grouped as follows: Technology 1: Air Blown SCT-CPO of Gaseous Hydrocarbons and/or Light Compounds with biological origin Technology 2: Enriched Air/Oxygen Blown SCT-CPO of Gaseous Hydrocarbons and/or Light Compounds with biological origin Technology 3: Enriched Air/Oxygen Blown SCT-CPO of Liquid Hydrocarbons and/or Compounds with biological origin Recently, the licence rights on a non-exclusive basis for the commercialisation of SCT-CPO based processes for H{sub 2}/Synthesis gas production from light hydrocarbons with production capacity lower than 5,000 Nm{sup 3}/h of H{sub 2} or 7,500 Nm3/h of syngas have been assigned to two external companies. In parallel, development of medium- and large-scale plant solutions is progressing within the ENI group framework. These last activities are addressed to the utilisation of SCT-CPO for matching the variable Hydrogen demand in several contexts of oil refining operation. This paper will report on the current status of SCT-CPO with a focus on experimental results obtained, either at pilot- and bench- scale level. (orig.)

  20. Advanced byproduct recovery: Direct catalytic reduction of sulfur dioxide to elemental sulfur. Quarterly report, April 1--June 30, 1997

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-12-31

    The team of Arthur D. Little, Tufts University and Engelhard Corporation are conducting Phase 1 of a four and a half year, two-phase effort to develop and scale-up an advanced byproduct recovery technology that is a direct, single-stage, catalytic process for converting sulfur dioxide to elemental sulfur. This catalytic process reduces SO{sub 2} over a fluorite-type oxide (such as ceria and zirconia). The catalytic activity can be significantly promoted by active transition metals, such as copper. More than 95% elemental sulfur yield, corresponding to almost complete sulfur dioxide conversion, was obtained over a Cu-Ce-O oxide catalyst as part of an on-going DOE-sponsored, University Coal Research Program. This type of mixed metal oxide catalyst has stable activity, high selectivity for sulfur production, and is resistant to water and carbon dioxide poisoning. Tests with CO and CH{sub 4} reducing gases indicate that the catalyst has the potential for flexibility with regard to the composition of the reducing gas, making it attractive for utility use. The performance of the catalyst is consistently good over a range of SO{sub 2} inlet concentration (0.1 to 10%) indicating its flexibility in treating SO{sub 2} tail gases as well as high concentration streams. The principal objective of the Phase 1 program is to identify and evaluate the performance of a catalyst which is robust and flexible with regard to choice of reducing gas. In order to achieve this goal, the authors have planned a structured program including: Market/process/cost/evaluation; Lab-scale catalyst preparation/optimization studies; Lab-scale, bulk/supported catalyst kinetic studies; Bench-scale catalyst/process studies; and Utility review. Progress is reported from all three organizations.

  1. Environmental Barrier Coating Development for SiC/SiC Ceramic Matrix Composites: Recent Advances and Future Directions

    Science.gov (United States)

    Zhu, Dongming

    2016-01-01

    This presentation briefly reviews the SiC/SiC major environmental and environment-fatigue degradations encountered in simulated turbine combustion environments, and thus NASA environmental barrier coating system evolution for protecting the SiC/SiC Ceramic Matrix Composites for meeting the engine performance requirements. The presentation will review several generations of NASA EBC materials systems, EBC-CMC component system technologies for SiC/SiC ceramic matrix composite combustors and turbine airfoils, highlighting the temperature capability and durability improvements in simulated engine high heat flux, high pressure, high velocity, and with mechanical creep and fatigue loading conditions. This paper will also focus on the performance requirements and design considerations of environmental barrier coatings for next generation turbine engine applications. The current development emphasis is placed on advanced NASA candidate environmental barrier coating systems for SiC/SiC CMCs, their performance benefits and design limitations in long-term operation and combustion environments. The efforts have been also directed to developing prime-reliant, self-healing 2700F EBC bond coat; and high stability, lower thermal conductivity, and durable EBC top coats. Major technical barriers in developing environmental barrier coating systems, the coating integrations with next generation CMCs having the improved environmental stability, erosion-impact resistance, and long-term fatigue-environment system durability performance will be described. The research and development opportunities for turbine engine environmental barrier coating systems by utilizing improved compositions, state-of-the-art processing methods, and simulated environment testing and durability modeling will be briefly discussed.

  2. Editorial, Workshop on New Directions for Advanced Computer Simulations and Experiments in Fusion-Related Plasma-Surface Interactions

    International Nuclear Information System (INIS)

    Because plasma-boundary physics encompasses some of the most important unresolved issues for both the International Thermonuclear Experimental Reactor (ITER) project and future fusion power reactors, there is a strong interest in the fusion community for better understanding and characterization of plasma-wall interactions. Chemical and physical sputtering cause the erosion of the limiters/divertor plates and vacuum vessel walls (made of C, Be and W, for example) and degrade fusion performance by diluting the fusion fuel and excessively cooling the core, while carbon redeposition could produce long-term in-vessel tritium retention, degrading the superior thermo-mechanical properties of the carbon materials. Mixed plasma-facing materials are proposed, requiring optimization for different power and particle flux characteristics. Knowledge of material properties as well as characteristics of the plasma-material interaction are prerequisites for such optimizations. Computational power will soon reach hundreds of teraflops, so that theoretical and plasma science expertise can be matched with new experimental capabilities in order to mount a strong response to these challenges. To begin to address such questions, a Workshop on New Directions for Advanced Computer Simulations and Experiments in Fusion-Related Plasma-Surface Interactions for Fusion (PSIF) was held at the Oak Ridge National Laboratory from 21 to 23 March, 2005. The purpose of the workshop was to bring together researchers in fusion related plasma-wall interactions in order to address these topics and to identify the most needed and promising directions for study, to exchange opinions on the present depth of knowledge of surface properties for the main fusion-related materials, e.g., C, Be and W, especially for sputtering, reflection, and deuterium (tritium) retention properties. The goal was to suggest the most important next steps needed for such basic computational and experimental work to be facilitated

  3. Direct assessment of the mechanical modulus of graphene co-doped with low concentrations of boron-nitrogen by a non-contact approach

    Science.gov (United States)

    Pan, Shun-Hsien; Medina, Henry; Wang, Sheng-Bo; Chou, Li-Jen; Wang, Zhiming M.; Chen, Kuei-Hsien; Chen, Li-Chyong; Chueh, Yu-Lun

    2014-07-01

    Boron and nitrogen co-doping has been shown to be an effective way to induce a band gap in graphene for electrical applications but only a few theoretical studies have been done to understand the elastic and mechanical properties of the modified graphene. Until now, no experimental assessment of the mechanical modulus of boron-nitrogen-doped graphene (BNG) has been reported in the literature. Here, we demonstrate a novel non-contact approach to determine the in-plane stiffness of BNG at low BN concentrations. The in-plane stiffness of BNG with 2 at% BN concentration was estimated to be about 309 N m-1, which is lower than that of pristine graphene, in good agreement with some theoretical studies. Moreover, we correlated the conductivity of BNG with induced strain and found the BNG to be more sensitive than pristine graphene in response to externally applied strain. This result indicates that BNG is a more suitable material than graphene for strain sensor applications.Boron and nitrogen co-doping has been shown to be an effective way to induce a band gap in graphene for electrical applications but only a few theoretical studies have been done to understand the elastic and mechanical properties of the modified graphene. Until now, no experimental assessment of the mechanical modulus of boron-nitrogen-doped graphene (BNG) has been reported in the literature. Here, we demonstrate a novel non-contact approach to determine the in-plane stiffness of BNG at low BN concentrations. The in-plane stiffness of BNG with 2 at% BN concentration was estimated to be about 309 N m-1, which is lower than that of pristine graphene, in good agreement with some theoretical studies. Moreover, we correlated the conductivity of BNG with induced strain and found the BNG to be more sensitive than pristine graphene in response to externally applied strain. This result indicates that BNG is a more suitable material than graphene for strain sensor applications. Electronic supplementary

  4. Contact: Releasing the news

    Science.gov (United States)

    Pinotti, Roberto

    The problem of mass behavior after man's future contacts with other intelligences in the universe is not only a challenge for social scientists and political leaders all over the world, but also a cultural time bomb as well. In fact, since the impact of CETI (Contact with Extraterrestrial Intelligence) on human civilization, with its different cultures, might cause a serious socio-anthropological shock, a common and predetermined worldwide strategy is necessary in releasing the news after the contact, in order to keep possible manifestations of fear, panic and hysteria under control. An analysis of past studies in this field and of parallel historical situations as analogs suggests a definite "authority crisis" in the public as a direct consequence of an unexpected release of the news, involving a devastating "chain reaction" process (from both the psychological and sociological viewpoints) of anomie and maybe the collapse of today's society. The only way to prevent all this is to prepare the world's public opinion concerning contact before releasing the news, and to develop a long-term strategy through the combined efforts of scientists, political leaders, intelligence agencies and the mass media, in order to create the cultural conditions in which a confrontation with ETI won't affect mankind in a traumatic way. Definite roles and tasks in this multi-level model are suggested.

  5. Almost contact 5-folds are contact

    CERN Document Server

    Casals, Roger; Presas, Francisco

    2012-01-01

    We prove that every homotopy class of an almost contact structure on a closed 5-dimensional manifold with no 2-torsion in $H^2(M,\\Z)$ admits a contact structure. If there is 2-torsion, we prove that there is a contact structure with the same first Chern class as the given almost contact structure.

  6. Lipstick Induced Contact Leucoderma

    OpenAIRE

    Gupta Lalit Kumar; Jain Suresh Kumar; Khare Ashok Kumar

    2001-01-01

    Lipstick is a commonly used cosmetic. Its use may sometimes lead to contact dermatitis. Contact leucoderma to lipsticks however, is not common. We report a patient developing contact leucoderma to lipstick in association with contact dermatitis.

  7. Lipstick Induced Contact Leucoderma

    Directory of Open Access Journals (Sweden)

    Gupta Lalit Kumar

    2001-01-01

    Full Text Available Lipstick is a commonly used cosmetic. Its use may sometimes lead to contact dermatitis. Contact leucoderma to lipsticks however, is not common. We report a patient developing contact leucoderma to lipstick in association with contact dermatitis.

  8. Simulation and economic analysis of a liquid-based solar system with a direct-contact liquid-liquid heat exchanger, in comparison to a system with a conventional heat exchanger

    Science.gov (United States)

    Brothers, P.; Karaki, S.

    Using a solar computer simulation package called TRNSYS, simulations of the direct contact liquid-liquid heat exchanger (DCLLHE) solar system and a system with conventional shell-and-tube heat exchanger were developed, based in part on performance measurements of the actual systems. The two systems were simulated over a full year on an hour-by-hour basis at five locations; Boston, Massachusetts, Charleston, South Carolina, Dodge City, Kansas, Madison, Wisconsin, and Phoenix, Arizona. Typically the direct-contact system supplies slightly more heat for domestic hot water and space heating in all locations and about 5 percentage points more cooling as compared to the conventional system. Using a common set of economic parameters and the appropriate federal and state income tax credits, as well as property tax legislation for solar systems in the corresponding states, the results of the study indicate for heating-only systems, the DCLLHE system has a slight life-cycle cost disadvantage compared to the conventional system. For combined solar heating and cooling systems, the DCLLHE has a slight life-cycle cost advantage which varies with location and amounts to one to three percent difference from the conventional system.

  9. Comparative Evaluation of the Antibacterial Efficacy of Type II Glass lonomer Cement, Type IX Glass lonomer Cement, and AMALGOMER™ Ceramic Reinforcement by Modified “Direct Contact Test”: An in vitro Study

    Science.gov (United States)

    Assudani, Harsha G; Patil, Vidyavathi; Kukreja, Pratibha; Uppin, Chaitanya; Thakkar, Prachi

    2016-01-01

    ABSTRACT Background: Streptococcus mutans (ATCC25175) has a profound effect on the incidence of dental decay in the human population. Many studies have been performed to assess the antimicrobial activity of different cements. However, little or no information is available about the antibacterial properties of Type II glass ionomer cement (GIC), Type IX GIC, and AMALGOMER™ ceramic reinforcement (CR). Aim: To comparatively evaluate the antibacterial activity of Type II GIC, Type IX GIC, and AMALGOMER™ CR by modified direct contact test. Materials and methods: The total sample size was 72 which was divided into four study groups. Six wells were coated by each: Type II GIC, Type IX GIC, AMALGOMER™ CR, and control group (only S. mutans). Statistical analysis was done using analysis of variance and the intergroup comparison was done using post hoc Tukey test. Results: AMALGOMER™ CR was found to have a better antibacterial effect as compared with Type II and IX GIC. Conclusion: AMALGOMER™ CR can serve as a valuable cement in pediatric dentistry due to its anticariogenic property. How to cite this article: Hugar SM, Assudani HG, Patil V, Kukreja P, Uppin C, Thakkar P. Comparative Evaluation of the Antibacterial Efficacy of Type II Glass lonomer Cement, Type IX Glass Ionomer Cement, and AMALGOMER™ Ceramic Reinforcement by Modified “Direct Contact Test”: An in vitro Study. Int J Clin Pediatr Dent 2016;9(2):114-117. PMID:27365930

  10. EDITORIAL: Close contact Close contact

    Science.gov (United States)

    Demming, Anna

    2010-07-01

    The development of scanning probe techniques, such as scanning tunnelling microscopy [1], has often been touted as the catalyst for the surge in activity and progress in nanoscale science and technology. Images of nanoscale structural detail have served as an invaluable investigative resource and continue to fascinate with the fantastical reality of an intricate nether world existing all around us, but hidden from view of the naked eye by a disparity in scale. As is so often the case, the invention of the scanning tunnelling microscope heralded far more than just a useful new apparatus, it demonstrated the scope for exploiting the subtleties of electronic contact. The shrinking of electronic devices has been a driving force for research into molecular electronics, in which an understanding of the nature of electronic contact at junctions is crucial. In response, the number of experimental techniques in molecular electronics has increased rapidly in recent years. Scanning tunnelling microscopes have been used to study electron transfer through molecular films on a conducting substrate, and the need to monitor the contact force of scanning tunnelling electrodes led to the use of atomic force microscopy probes coated in a conducting layer as studied by Cui and colleagues in Arizona [2]. In this issue a collaboration of researchers at Delft University and Leiden University in the Netherlands report a new device architecture for the independent mechanical and electrostatic tuning of nanoscale charge transport, which will enable thorough studies of molecular transport in the future [3]. Scanning probes can also be used to pattern surfaces, such as through spatially-localized Suzuki and Heck reactions in chemical scanning probe lithography. Mechanistic aspects of spatially confined Suzuki and Heck chemistry are also reported in this issue by researchers in Oxford [4]. All these developments in molecular electronics fabrication and characterization provide alternative

  11. Non-targeted screening for contaminants in paper and board food-contact materials using effect-directed analysis and accurate mass spectrometry.

    Science.gov (United States)

    Bengtström, Linda; Rosenmai, Anna Kjerstine; Trier, Xenia; Jensen, Lisbeth Krüger; Granby, Kit; Vinggaard, Anne Marie; Driffield, Malcolm; Højslev Petersen, Jens

    2016-06-01

    Due to large knowledge gaps in chemical composition and toxicological data for substances involved, paper and board food-contact materials (P&B FCM) have been emerging as a FCM type of particular concern for consumer safety. This study describes the development of a step-by-step strategy, including extraction, high-performance liquid chromatography (HPLC) fractionation, tentative identification of relevant substances and in vitro testing of selected tentatively identified substances. As a case study, we used two fractions from a recycled pizza box sample which exhibited aryl hydrocarbon receptor (AhR) activity. These fractions were analysed by gas chromatography (GC) and ultra-HPLC (UHPLC) coupled to quadrupole time-of-flight mass spectrometers (QTOF MS) in order tentatively to identify substances. The elemental composition was determined for peaks above a threshold, and compared with entries in a commercial mass spectral library for GC-MS (GC-EI-QTOF MS) analysis and an in-house built library of accurate masses for substances known to be used in P&B packaging for UHPLC-QTOF analysis. Of 75 tentatively identified substances, 15 were initially selected for further testing in vitro; however, only seven were commercially available and subsequently tested in vitro and quantified. Of these seven, the identities of three pigments found in printing inks were confirmed by UHPLC tandem mass spectrometry (QqQ MS/MS). Two pigments had entries in the database, meaning that a material relevant accurate mass database can provide a fast tentative identification. Pure standards of the seven tentatively identified substances were tested in vitro but could not explain a significant proportion of the AhR-response in the extract. Targeted analyses of dioxins and PCBs, both well-known AhR agonists, was performed. However, the dioxins could explain approximately 3% of the activity observed in the pizza box extract indicating that some very AhR active substance(s) still remain to be

  12. Physician perspectives and compliance with patient advance directives: the role external factors play on physician decision making

    Directory of Open Access Journals (Sweden)

    Burkle Christopher M

    2012-11-01

    Full Text Available Abstract Background Following passage of the Patient Self Determination Act in 1990, health care institutions that receive Medicare and Medicaid funding are required to inform patients of their right to make their health care preferences known through execution of a living will and/or to appoint a surrogate-decision maker. We evaluated the impact of external factors and perceived patient preferences on physicians’ decisions to honor or forgo previously established advance directives (ADs. In addition, physician views regarding legal risk, patients’ ability to comprehend complexities involved with their care, and impact of medical costs related to end-of-life care decisions were explored. Methods Attendees of two Mayo Clinic continuing medical education courses were surveyed. Three scenarios based in part on previously court-litigated matters assessed impact of external factors and perceived patient preferences on physician compliance with patient-articulated wishes regarding resuscitation. General questions measured respondents’ perception of legal risk, concerns over patient knowledge of idiosyncrasies involved with their care, and impact medical costs may have on compliance with patient preferences. Responses indicating strength of agreement or disagreement with statements were treated as ordinal data and analyzed using the Cochran Armitage trend test. Results Three hundred eighty-eight of 951 surveys were completed (41% response rate. Eighty percent reported they were likely to honor a patient’s AD despite its 5 year age. Fewer than half (41% would honor the AD of a patient in ventricular fibrillation who had expressed a desire to “pass away in peace.” Few (17% would forgo an AD following a family’s request for continued resuscitative treatment. A majority (52% considered risk of liability to be lower when maintaining someone alive against their wishes than mistakenly failing to provide resuscitative efforts. A large percentage

  13. Direct Melanoma Cell Contact Induces Stromal Cell Autocrine Prostaglandin E2-EP4 Receptor Signaling That Drives Tumor Growth, Angiogenesis, and Metastasis.

    Science.gov (United States)

    Inada, Masaki; Takita, Morichika; Yokoyama, Satoshi; Watanabe, Kenta; Tominari, Tsukasa; Matsumoto, Chiho; Hirata, Michiko; Maru, Yoshiro; Maruyama, Takayuki; Sugimoto, Yukihiko; Narumiya, Shuh; Uematsu, Satoshi; Akira, Shizuo; Murphy, Gillian; Nagase, Hideaki; Miyaura, Chisato

    2015-12-11

    The stromal cells associated with tumors such as melanoma are significant determinants of tumor growth and metastasis. Using membrane-bound prostaglandin E synthase 1 (mPges1(-/-)) mice, we show that prostaglandin E2 (PGE2) production by host tissues is critical for B16 melanoma growth, angiogenesis, and metastasis to both bone and soft tissues. Concomitant studies in vitro showed that PGE2 production by fibroblasts is regulated by direct interaction with B16 cells. Autocrine activity of PGE2 further regulates the production of angiogenic factors by fibroblasts, which are key to the vascularization of both primary and metastatic tumor growth. Similarly, cell-cell interactions between B16 cells and host osteoblasts modulate mPGES-1 activity and PGE2 production by the osteoblasts. PGE2, in turn, acts to stimulate receptor activator of NF-κB ligand expression, leading to osteoclast differentiation and bone erosion. Using eicosanoid receptor antagonists, we show that PGE2 acts on osteoblasts and fibroblasts in the tumor microenvironment through the EP4 receptor. Metastatic tumor growth and vascularization in soft tissues was abrogated by an EP4 receptor antagonist. EP4-null Ptger4(-/-) mice do not support B16 melanoma growth. In vitro, an EP4 receptor antagonist modulated PGE2 effects on fibroblast production of angiogenic factors. Our data show that B16 melanoma cells directly influence host stromal cells to generate PGE2 signals governing neoangiogenesis and metastatic growth in bone via osteoclast erosive activity as well as angiogenesis in soft tissue tumors. PMID:26475855

  14. 7 CFR 1737.10 - Initial contact.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Initial contact. 1737.10 Section 1737.10 Agriculture... Preapplication Stage § 1737.10 Initial contact. Initial loan applicants seeking assistance should write the Rural.... Existing borrowers initiate the contact directly with their assigned field representative....

  15. Partial direct contact transmission in ferrets of a mallard H7N3 influenza virus with typical avian-like receptor specificity

    Directory of Open Access Journals (Sweden)

    Araya Yonas

    2009-08-01

    Full Text Available Abstract Background Avian influenza viruses of the H7 subtype have caused multiple outbreaks in domestic poultry and represent a significant threat to public health due to their propensity to occasionally transmit directly from birds to humans. In order to better understand the cross species transmission potential of H7 viruses in nature, we performed biological and molecular characterizations of an H7N3 virus isolated from mallards in Canada in 2001. Results Sequence analysis that the HA gene of the mallard H7N3 virus shares 97% identity with the highly pathogenic avian influenza (HPAI H7N3 virus isolated from a human case in British Columbia, Canada in 2004. The mallard H7N3 virus was able to replicate in quail and chickens, and transmitted efficiently in quail but not in chickens. Interestingly, although this virus showed preferential binding to analogs of avian-like receptors with sialic acid (SA linked to galactose in an α2–3 linkage (SAα2–3Gal, it replicated to high titers in cultures of primary human airway epithelial (HAE cells, comparable to an avian H9N2 influenza virus with human-like α2–6 linkage receptors (SAα2–6Gal. In addition, the virus replicated in mice and ferrets without prior adaptation and was able to transmit partially among ferrets. Conclusion Our findings highlight the importance and need for systematic in vitro and in vivo analysis of avian influenza viruses isolated from the natural reservoir in order to define their zoonotic potential.

  16. Scientific Opinion on the safety assessment of the process LPR based on EREMA Advanced and Colortronic SSP ® technology used to recycle post-consumer PET into food contact materials

    Directory of Open Access Journals (Sweden)

    EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF

    2014-02-01

    Full Text Available This scientific opinion of the EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids deals with the safety assessment of the recycling process LPR (EU register No RECYC061 which is based on the EREMA advanced and Colortronic SSP ® technologies. The input to the process is hot caustic washed and dried PET flakes originating from collected post-consumer PET bottles and containing no more than 5 % of PET from non-food consumer applications. In this process, washed and dried PET flakes are heated successively in two continuous reactors under vacuum before being extruded into pellets. After extrusion they are crystallised and solid state polymerized. Having examined the results of the challenge test provided, the Panel concluded that the four steps, the decontamination in two continuous reactors, extrusion, crystallisation and solid state polymerization are the critical steps that determine the decontamination efficiency of the process. The operating parameters to control the performance of these critical steps are temperature, pressure, gas flow and residence time. Under these conditions, it was demonstrated that the recycling process is able to ensure that the level of migration of potential unknown contaminants into food is below the modelled migration of 0.1 μg/kg food derived from exposure scenario for infants and 0.15 μg/kg food derived from the exposure scenario for toddlers. The Panel concluded that recycled PET obtained from LPR process is not of safety concern when used to manufacture articles intended for food contact materials applications in compliance with the conditions as specified in the conclusion of the opinion.

  17. Contact Control, Version 1

    Energy Technology Data Exchange (ETDEWEB)

    2016-07-21

    The contact control code is a generalized force control scheme meant to interface with a robotic arm being controlled using the Robot Operating System (ROS). The code allows the user to specify a control scheme for each control dimension in a way that many different control task controllers could be built from the same generalized controller. The input to the code includes maximum velocity, maximum force, maximum displacement, and a control law assigned to each direction and the output is a 6 degree of freedom velocity command that is sent to the robot controller.

  18. 精神障碍患者的预先指示权与自愿治疗%Mentally disordered patients' right to advance directives and voluntary treatment

    Institute of Scientific and Technical Information of China (English)

    孙也龙

    2013-01-01

    《中华人民共和国精神卫生法》确立了精神障碍患者自愿治疗原则,预先指示权应是这项原则的重要内容.预先指示权不仅能够保障患者自治,而且也具有多重的现实意义.我国具有确立预先指示权的法律环境,但大众对预先指示权比较陌生,建议对其进行适当的提倡和推广.%Mental Health Law of the People's Republic of China establishes the principle of voluntary treatment for mentally disordered patients. The right to advance directives should be an important aspect of the principle of voluntary treatment because it can protect mentally disordered patients'autonomy and has multiple practical values. China has the legal environment to establish mentally disordered patients'right to advance directives. However, most Chinese people are not fairly familiar with this right Therefore it is suggested to advocate and promote the right to advance directives in China.

  19. Contact homology of good toric contact manifolds

    CERN Document Server

    Abreu, Miguel

    2010-01-01

    In this paper we show that any good toric contact manifold has well defined cylindrical contact homology and describe how it can be combinatorially computed from the associated moment cone. As an application we compute the cylindrical contact homology of a particularly nice family of examples that appear in the work of Gauntlett-Martelli-Sparks-Waldram on Sasaki-Einstein metrics. We show in particular that these give rise to a new infinite family of non-equivalent contact structures on $S^2 \\times S^{3}$ in the unique homotopy class of almost contact structures with vanishing first Chern class.

  20. Contact Lens Solution Toxicity

    Science.gov (United States)

    ... rash and rashes clinical tools newsletter | contact Share | Contact Lens Solution Toxicity Information for adults A A A This image shows a reaction to contact lens solution. The prominent blood vessels and redness ...

  1. Contact Lens Risks

    Science.gov (United States)

    ... Health and Consumer Devices Consumer Products Contact Lenses Contact Lens Risks Share Tweet Linkedin Pin it More ... redness blurred vision swelling pain Serious Hazards of Contact Lenses Symptoms of eye irritation can indicate a ...

  2. Diabetes and contact lens wear.

    Science.gov (United States)

    O'Donnell, Clare; Efron, Nathan

    2012-05-01

    The literature suggests that diabetic patients may have altered tear chemistry and tear secretion as well as structural and functional changes to the corneal epithelium, endothelium and nerves. These factors, together with a reported increased incidence of corneal infection, suggest that diabetic patients may be particularly susceptible to developing ocular complications during contact lens wear. Reports of contact lens-induced complications in diabetic patients do exist, although a number of these reports concern patients with advanced diabetic eye disease using lenses on an extended wear basis. Over the past decade or so, there have been published studies documenting the response of the diabetic eye to more modern contact lens modalities. The results of these studies suggest that contact lenses can be a viable mode of refractive correction for diabetic patients. Furthermore, new research suggests that the measurement of tear glucose concentration could, in future, be used to monitor metabolic control non-invasively in diabetic patients. This could be carried out using contact lenses manufactured from hydrogel polymers embedded with glucose-sensing agents or nanoscale digital electronic technology. The purpose of this paper is to review the literature on the anterior ocular manifestations of diabetes, particularly that pertaining to contact lens wear. PMID:22537249

  3. Contact handle decompositions

    OpenAIRE

    Özbağcı, Burak

    2009-01-01

    We review Giroux’s contact handles and contact handle attachments in dimension three and show that a bypass attachment consists of a pair of contact 1 and 2-handles. As an application we describe explicit contact handle decompositions of infinitely many pairwise non-isotopic overtwisted 3-spheres. We also give an alternative proof of the fact that every compact contact 3-manifold (closed or with convex boundary) admits a contact handle decomposition, which is a result originally due to Giroux.

  4. Advance directives and physicians' orders in nursing home residents with dementia in Flanders, Belgium: prevalence and associated outcomes

    OpenAIRE

    Vandervoort, An; Van den Block, Lieve; van der Steen, Jenny T; Vander Stichele, Robert; Bilsen, Johan; Deliens, Luc

    2012-01-01

    Background: Advance care planning (ACP) is an important element of high-quality care in nursing homes, especially for residents having dementia who are often incompetent in decision-making toward the end of life. The aim of this study was describe the prevalence of documented ACP among nursing home residents with dementia in Flanders, Belgium, and associated clinical characteristics and outcomes. Methods: All 594 nursing homes in Flanders were asked to participate in a retrospective cross...

  5. Advanced Manufacturing of Intermediate Temperature, Direct Methane Oxidation Membrane Electrode Assemblies for Durable Solid Oxide Fuel Cell Project

    Data.gov (United States)

    National Aeronautics and Space Administration — The proposed innovation builds on the successes of the Phase I program by integrating our direct oxidation membrane electrode assembly (MEA) into a monolithic solid...

  6. Integral manifolds of contact distributions

    International Nuclear Information System (INIS)

    The existence of an integral manifold of the contact distribution (a Legendre submanifold) that passes through an arbitrary point in a contact manifold M2n+1, in an arbitrary totally real n-dimensional direction is established. A Legendre submanifold with these initial data is not unique in general, but in the case of a K-contact manifold of dimension greater than 5 the set of these submanifolds is shown to contain a totally geodesic submanifold (which is called a Blair submanifold in the paper) if and only if this K-contact manifold is a Sasakian space form. Each Blair submanifold of a Sasakian space form of Φ-holomorphic sectional curvature c is a space of constant curvature (c+3)/4. Applications of these results to the geometry of principal toroidal bundles are found

  7. Contact Lenses for Vision Correction

    Science.gov (United States)

    ... Ask an Ophthalmologist Español Eye Health / Glasses & Contacts Contact Lenses Sections Contact Lenses for Vision Correction Proper ... to Know About Contact Lenses Colored Contact Lenses Contact Lenses for Vision Correction Written by: Kierstan Boyd ...

  8. Contact fiber bundles

    OpenAIRE

    Lerman, Eugene

    2003-01-01

    We define contact fiber bundles and investigate conditions for the existence of contact structures on the total space of such a bundle. The results are analogous to minimal coupling in symplectic geometry. The two applications are construction of K-contact manifolds generalizing Yamazaki's fiber join construction and a cross-section theorem for contact moment maps

  9. Systemic contact dermatitis

    Directory of Open Access Journals (Sweden)

    Daria Nowak

    2016-02-01

    Full Text Available Systemic contact dermatitis (SCD is a skin inflammation occurring in a patient after systemic administration of a hapten, which previously caused an allergic contact skin reaction in the same person. Most frequently, hypersensitivity reactions typical for SCD occur after absorption of haptens with food or inhalation. Haptens occur mainly in the forms of metals and compounds present in natural resins, preservatives, food thickeners, flavorings and medicines. For many years, several studies have been conducted on understanding the pathogenesis of SCD in which both delayed type hypersensitivity (type IV and immediate type I are observed. Components of the complement system are also suspected to attend there. Helper T cells (Th (Th1 and Th2, cytotoxic T lymphocytes (Tc, and NK cells play a crucial role in the pathogenesis of SCD. They secrete a number of pro-inflammatory cytokines. In addition, regulatory T cells (Tregs have an important role. They control and inhibit activity of the immune system during inflammation. Tregs release suppressor cytokines and interact directly with a target cell through presentation of immunosuppressive particles at the cell surface. Diagnostic methods are generally the patch test, oral provocation test, elimination diet and lymphocyte stimulation test. There are many kinds of inflammatory skin reactions caused by systemic haptens’ distribution. They are manifested in a variety of clinical phenotypes of the disease.

  10. Contact patterns among high school students

    CERN Document Server

    Fournet, Julie

    2014-01-01

    Face-to-face contacts between individuals contribute to shape social networks and play an important role in determining how infectious diseases can spread within a population. It is thus important to obtain accurate and reliable descriptions of human contact patterns occurring in various day-to-day life contexts. Recent technological advances and the development of wearable sensors able to sense proximity patterns have made it possible to gather data giving access to time-varying contact networks of individuals in specific environments. Here we present and analyze two such data sets describing with high temporal resolution the contact patterns of students in a high school. We define contact matrices describing the contact patterns between students of different classes and show the importance of the class structure. We take advantage of the fact that the two data sets were collected in the same setting during several days in two successive years to perform a longitudinal analysis on two very different timescal...

  11. Atmospheric pressure gas chromatography coupled to quadrupole-time of flight mass spectrometry as a tool for identification of volatile migrants from autoadhesive labels used for direct food contact.

    Science.gov (United States)

    Canellas, Elena; Vera, Paula; Nerín, Cristina

    2014-11-01

    Pressure-sensitive adhesives (PSA) are used to manufacture labels that are applied directly on the food. These adhesives could contain not only intentionally added compounds (IAS) to the adhesive formula but also non-intentionally added substances (NIAS), due to the impurities from the raw materials used, decomposition of the initial components or from chemical interactions between them. These compounds could migrate to the food and contaminate it. In this study, gas chromatography coupled with mass spectrometry (GC-MS/Q) and atmospheric pressure gas chromatography coupled to a quadrupole hyphenated to a time of flight mass spectrometer (APGC-MS/Q-TOF) have been used for identification of unknown compounds and NIAS coming from a PSA. Seven compounds were identified by GC-MS/Q, and other eight compounds remained initially unknown. The structure of these eight new compounds was elucidated by working with the spectra obtained by APGC-MS/Q-TOF. Finally, two different migration studies were carried out. The first one with Tenax as solid food simulant in contact with the paper label containing the adhesive and the second one with isooctane filled in a natural pork intestine where the label containing the adhesive was applied on the external side. The results are shown and discussed. PMID:25395134

  12. Development of advanced pump impeller fabrication technology using direct nano- ceramic dispersion casting for long time erosion durability

    Energy Technology Data Exchange (ETDEWEB)

    Rhee, Chang Kyu; Lee, Min Ku; Park, Jin Ju [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)] (and others)

    2008-09-15

    Many components of pump impeller of nuclear power plants is generally made of stainless steel and Al-bronze with superior corrosion resistance to sea water. However, they should be replaced by one- to five-year period because of material damage by a very big cavitation impact load, even though their designed durability is twenty years. Especially, in case of Young-Gwang nuclear power plant located at the west sea, damage of components of pump impeller is so critical due to the additional damage by solid particle erosion and hence their replacement period is very short as several months compared to other nuclear power plants. In addition, it is very difficult to maintain and repair the components of pump impeller since there is no database on the exact durability and damage mechanism. Therefore, in this study, fabrication technology of new advanced materials modified by dispersion of nano-carbide and -oxide ceramics into the matrix is developed first. Secondly, technology to estimate the dynamic damage by solid particle erosion is established and hence applied to the prediction of the service life of the components of pump impeller.

  13. Preoperative Direct Puncture Embolization of Advanced Juvenile Nasopharyngeal Angiofibroma in Combination with Transarterial Embolization: An Analysis of 22 Consecutive Patients

    Energy Technology Data Exchange (ETDEWEB)

    Lv Mingming, E-mail: lvmingming001@163.com; Fan, Xin-dong, E-mail: fanxindong@yahoo.com.cn [Shanghai Jiao Tong University School of Medicine, Department of Radiology, Ninth People' s Hospital (China); Su Lixin, E-mail: sulixin1975@126.com [Shanghai Jiao Tong University School of Medicine, Department of Oral and Maxillofacial Surgery, Ninth People' s Hospital (China); Chen Dong, E-mail: chenjsun@public8.sta.net.cn [Shanghai Jiao Tong University School of Medicine, Department of Otolaryngology, Ninth People' s Hospital (China)

    2013-02-15

    ObjectiveThis study was designed to evaluate the clinical application of preoperative auxiliary embolization for juvenile nasopharyngeal angiofibroma (JNA) by direct puncture embolization (DPE) of the tumor in combination with transarterial embolization (TAE). The study included 22 patients. An 18-gauge needle was used to puncture directly into the tumor, and 20-25 % N-butyl cyanoacrylate was injected under the guidance of fluoroscopy after confirming the placement of the needle into the JNA and no leaking into the surrounding tissue. Tumors were obstructed later via TAE. The supplying arteries of JNA were from branches of the internal carotid and external carotid arteries. Control angiography showed the obliteration of contrast stain in the entire tumor mass and the distal supplying arteries disappeared after DPE in combination with TAE. Surgical resection was performed within 4 days after embolization and none of the patients required blood transfusion. The use of DPE in combination with TAE was a safe, feasible, and efficacious method. It can devascularize effectively the JNAs and reduce intraoperative bleeding when JNAs are extirpated.

  14. Preoperative Direct Puncture Embolization of Advanced Juvenile Nasopharyngeal Angiofibroma in Combination with Transarterial Embolization: An Analysis of 22 Consecutive Patients

    International Nuclear Information System (INIS)

    ObjectiveThis study was designed to evaluate the clinical application of preoperative auxiliary embolization for juvenile nasopharyngeal angiofibroma (JNA) by direct puncture embolization (DPE) of the tumor in combination with transarterial embolization (TAE). The study included 22 patients. An 18-gauge needle was used to puncture directly into the tumor, and 20–25 % N-butyl cyanoacrylate was injected under the guidance of fluoroscopy after confirming the placement of the needle into the JNA and no leaking into the surrounding tissue. Tumors were obstructed later via TAE. The supplying arteries of JNA were from branches of the internal carotid and external carotid arteries. Control angiography showed the obliteration of contrast stain in the entire tumor mass and the distal supplying arteries disappeared after DPE in combination with TAE. Surgical resection was performed within 4 days after embolization and none of the patients required blood transfusion. The use of DPE in combination with TAE was a safe, feasible, and efficacious method. It can devascularize effectively the JNAs and reduce intraoperative bleeding when JNAs are extirpated.

  15. Development of advanced direct perception displays for nuclear power plants to enhance monitoring, control and fault management

    International Nuclear Information System (INIS)

    Traditional Single-Sensor-Single Indicator (SSSI) displays are poorly matched to the cognitive abilities of operators, especially for large and complex systems. It is difficult for operators to monitor very large arrays of displays and controls, and to integrate the information displayed therein. In addition, standard operating procedures (SOPs) are bulky (running to many hundreds of pages) and difficult to use, and operators may become lost. For these reasons, and also because it is becoming increasingly difficult to find replacements for aging hardware components, there is a trend towards computerized graphical interfaces for nuclear power plants (NPPs). There is, however, little rational theory for display design in this domain. This report describes some recent theoretical developments and shows how to develop displays which will greatly reduce the cognitive load on the operator and allow the use of perceptual rather than cognitive mechanisms while using SON and to support state diagnosis and fault management. The report outlines the conceptual framework within which such a new approach could be developed, and provides an example of how the operating procedures for the start-up sequence of a NPP could be realized. A detailed description of a set of displays for a graphical interface for the SON of the feedwater system is provided as an example of how the proposed approach could be realized, and a general account of how it would fit into the overall start-up sequence is given. Examples of open-quotes direct perceptionclose quotes or open-quotes ecologicalclose quotes configural state space displays to support the use of the proposed direct manipulation SOP interface are provided, and also a critical discussion which identifies some difficulties which may be anticipated should the general approach herein advocated be adopted

  16. Development of advanced direct perception displays for nuclear power plants to enhance monitoring, control and fault management

    Energy Technology Data Exchange (ETDEWEB)

    Jones, B.G.; Shaheen, S.; Moray, N. [and others

    1997-08-01

    Traditional Single-Sensor-Single Indicator (SSSI) displays are poorly matched to the cognitive abilities of operators, especially for large and complex systems. It is difficult for operators to monitor very large arrays of displays and controls, and to integrate the information displayed therein. In addition, standard operating procedures (SOPs) are bulky (running to many hundreds of pages) and difficult to use, and operators may become lost. For these reasons, and also because it is becoming increasingly difficult to find replacements for aging hardware components, there is a trend towards computerized graphical interfaces for nuclear power plants (NPPs). There is, however, little rational theory for display design in this domain. This report describes some recent theoretical developments and shows how to develop displays which will greatly reduce the cognitive load on the operator and allow the use of perceptual rather than cognitive mechanisms while using SON and to support state diagnosis and fault management. The report outlines the conceptual framework within which such a new approach could be developed, and provides an example of how the operating procedures for the start-up sequence of a NPP could be realized. A detailed description of a set of displays for a graphical interface for the SON of the feedwater system is provided as an example of how the proposed approach could be realized, and a general account of how it would fit into the overall start-up sequence is given. Examples of {open_quotes}direct perception{close_quotes} or {open_quotes}ecological{close_quotes} configural state space displays to support the use of the proposed direct manipulation SOP interface are provided, and also a critical discussion which identifies some difficulties which may be anticipated should the general approach herein advocated be adopted.

  17. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... like a suction cup." Halloween is a popular time for people to use colored contact lenses to ... wear costume contact lenses for Halloween or any time of year, follow these guidelines: Get an eye ...

  18. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... popping touch. But colored contact lenses are popular year-round, not just at Halloween. But few know ... contact lenses for Halloween or any time of year, follow these guidelines: Get an eye exam from ...

  19. Irritant Contact Dermatitis

    Science.gov (United States)

    ... rashes clinical tools newsletter | contact Share | Irritant Contact Dermatitis Information for adults A A A This image ... scaling bumps and slightly elevated lesions typical of dermatitis, with severe involvement in the patient's armpit. Overview ...

  20. Corporate Consumer Contact API

    Data.gov (United States)

    General Services Administration — The data in the Corporate Consumer Contact API is based on the content you can find in the Corporate Consumer Contact listing in the Consumer Action Handbook (PDF)....

  1. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... sell contacts without a prescription are breaking the law, and may be fined $11,000 per violation. " ... about the members of the eye-care team . Consumer warning about the improper use of colored contact ...

  2. Complementary Barrier Infrared Detector (CBIRD) Contact Methods

    Science.gov (United States)

    Ting, David Z.; Hill, Cory J.; Gunapala, Sarath D.

    2013-01-01

    The performance of the CBIRD detector is enhanced by using new device contacting methods that have been developed. The detector structure features a narrow gap adsorber sandwiched between a pair of complementary, unipolar barriers that are, in turn, surrounded by contact layers. In this innovation, the contact adjacent to the hole barrier is doped n-type, while the contact adjacent to the electron barrier is doped p-type. The contact layers can have wider bandgaps than the adsorber layer, so long as good electrical contacts are made to them. If good electrical contacts are made to either (or both) of the barriers, then one could contact the barrier(s) directly, obviating the need for additional contact layers. Both the left and right contacts can be doped either n-type or ptype. Having an n-type contact layer next to the electron barrier creates a second p-n junction (the first being the one between the hole barrier and the adsorber) over which applied bias could drop. This reduces the voltage drop over the adsorber, thereby reducing dark current generation in the adsorber region.

  3. New Cosmetic Contact Allergens

    OpenAIRE

    An Goossens

    2015-01-01

    Allergic and photo-allergic contact dermatitis, and immunologic contact urticaria are potential immune-mediated adverse effects from cosmetics. Fragrance components and preservatives are certainly the most frequently observed allergens; however, all ingredients must be considered when investigating for contact allergy.

  4. Mixed lubricated line contacts

    NARCIS (Netherlands)

    Faraon, Irinel Cosmin

    2005-01-01

    The present work deals with friction in mixed lubricated line contacts. Components in systems are becoming smaller and due to, for instance power transmitted, partial contact may occur. In industrial applications, friction between the moving contacting surfaces cannot be avoided, therefore it is ess

  5. New Cosmetic Contact Allergens

    Directory of Open Access Journals (Sweden)

    An Goossens

    2015-02-01

    Full Text Available Allergic and photo-allergic contact dermatitis, and immunologic contact urticaria are potential immune-mediated adverse effects from cosmetics. Fragrance components and preservatives are certainly the most frequently observed allergens; however, all ingredients must be considered when investigating for contact allergy.

  6. Facile synthesis of Pt-Pd@Silicon nanostructure as an advanced electrocatalyst for direct methanol fuel cells

    Science.gov (United States)

    Ensafi, Ali A.; Jafari-Asl, M.; Rezaei, B.; Abarghoui, M. Mokhtari; Farrokhpour, H.

    2015-05-01

    In this work, platinum-palladium (Pt-Pd) is assembled in-situ on the surface of porous silicon flour (PSiF) through chemical reduction of PtCl62-/PdCl42- and oxidation of the precursor solution SiF64-. The components and the morphological properties of the Pt-Pd on PSiF is investigated by means of transmission electron microscopy, energy dispersive X-ray spectroscopy, X-ray photoelectron spectroscopy, and X-ray diffraction techniques. In the next stage, screen printed graphene electrode (SPGE) is prepared by electro-reduction of exfoliated graphene oxide at the surface of a screen printed carbon electrode (SPCE), which is subsequently characterized by FT-IR, Raman spectroscopy, FE-SEM, and electrochemical methods. Finally, a combination of Pt-Pd@PSi nanostructure and SPGE is used for the electro-oxidation of methanol in direct methanol fuel cell. The electrochemical results demonstrate that the Pt-Pd@PSiF-SPGE exhibits an excellent electrocatalytic activity for methanol oxidation. In addition, the electron transfer kinetic of methanol oxidation on Pt-Pd@PSiF-SPGE is investigated by electrochemical impedance spectroscopy. The results showed that the surface of Pt-Pd@PSiF-SPGE is not affected (poisoned) by intermediate products such as CO.

  7. DYNAMIC CONTACT STIFFNESS OF VIBRATING RIGID SPHERE CONTACTING SEMI-INFINITE TRANSVERSELY ISOTROPIC VISCOELASTIC SOLID

    Institute of Scientific and Technical Information of China (English)

    Jiayong Tian; Zhoumin Xie

    2008-01-01

    Dynamic contact stiffness at the interface between a vibrating rigid sphere and a semi-infinite transversely isotropic viscoelastic solid is investigated. An oscillating force superimposed onto a static compressive force in the vertical direction excites the vibration of a rigid sphere, which causes variable contact radius and contact pressure distribution in the contact region. The assumption of a sufficiently small oscillating force yields a dynamic contact-pressure distribution of a constant contact radius, which gives dynamic contact stiffness at the interface between the rigid sphere and the semi-infinite solid. Numerical calculations show the influence of vibration frequency of the sphere, and elastic constants of the transversely isotropic solid on dynamic contact stiffness, which benefits quantitative evaluation of elastic constants and orientation of single hexagonal grains by resonance-frequency shifts of the oscillator in resonance ultrasound microscopy.

  8. Advances in the simulation and automated measurement of well-sorted granular material: 2. Direct measures of particle properties

    Science.gov (United States)

    Buscombe, Daniel D.; Rubin, David M.

    2012-01-01

    1. In this, the second of a pair of papers on the structure of well-sorted natural granular material (sediment), new methods are described for automated measurements from images of sediment, of: 1) particle-size standard deviation (arithmetic sorting) with and without apparent void fraction; and 2) mean particle size in material with void fraction. A variety of simulations of granular material are used for testing purposes, in addition to images of natural sediment. Simulations are also used to establish that the effects on automated particle sizing of grains visible through the interstices of the grains at the very surface of a granular material continue to a depth of approximately 4 grain diameters and that this is independent of mean particle size. Ensemble root-mean squared error between observed and estimated arithmetic sorting coefficients for 262 images of natural silts, sands and gravels (drawn from 8 populations) is 31%, which reduces to 27% if adjusted for bias (slope correction between observed and estimated values). These methods allow non-intrusive and fully automated measurements of surfaces of unconsolidated granular material. With no tunable parameters or empirically derived coefficients, they should be broadly universal in appropriate applications. However, empirical corrections may need to be applied for the most accurate results. Finally, analytical formulas are derived for the one-step pore-particle transition probability matrix, estimated from the image's autocorrelogram, from which void fraction of a section of granular material can be estimated directly. This model gives excellent predictions of bulk void fraction yet imperfect predictions of pore-particle transitions.

  9. Crane-Load Contact Sensor

    Science.gov (United States)

    Youngquist, Robert; Mata, Carlos; Cox, Robert

    2005-01-01

    An electronic instrument has been developed as a prototype of a portable crane-load contact sensor. Such a sensor could be helpful in an application in which the load rests on a base in a horizontal position determined by vertical alignment pins (see Figure 1). If the crane is not positioned to lift the load precisely vertically, then the load can be expected to swing once it has been lifted clear of the pins. If the load is especially heavy, large, and/or fragile, it could hurt workers and/or damage itself and nearby objects. By indicating whether the load remains in contact with the pins when it has been lifted a fraction of the length of the pins, the crane-load contact sensor helps the crane operator determine whether it is safe to lift the load clear of the pins: If there is contact, then the load is resting against the sides of the pins and, hence, it may not be safe to lift; if contact is occasionally broken, then the load is probably not resting against the pins, so it should be safe to lift. It is assumed that the load and base, or at least the pins and the surfaces of the alignment holes in the load, are electrically conductive, so the instrument can use electrical contact to indicate mechanical contact. However, DC resistance cannot be used as an indicator of contact for the following reasons: The load and the base are both electrically grounded through cables (the load is grounded through the lifting cable of the crane) to prevent discharge of static electricity. In other words, the DC resistance between the load and the pins is always low, as though they were always in direct contact. Therefore, instead of DC resistance, the instrument utilizes the AC electrical impedance between the pins and the load. The signal frequency used in the measurement is high enough (.1 MHz) that the impedance contributed by the cables and the electrical ground network of the building in which the crane and the base are situated is significantly greater than the contact

  10. Contact lens in keratoconus

    Directory of Open Access Journals (Sweden)

    Varsha M Rathi

    2013-01-01

    Full Text Available Contact lenses are required for the visual improvement in patients with keratoconus. Various contact lens options, such as rigid gas permeable (RGP lenses, soft and soft toric lenses, piggy back contact lenses (PBCL, hybrid lenses and scleral lenses are availble. This article discusses about selection of a lens depending on the type of keratoconus and the fitting philosophies of various contact lenses including the starting trial lens. A Medline search was carried out for articles in the English language with the keywords keratoconus and various contact lenses such as Rose k lens, RGP lens, hybrid lens, scleral lens and PBCL.

  11. Advance directives in the perioperative setting: Managing ethical and legal issues when patient rights and perceived obligations of the healthcare provider conflict.

    Science.gov (United States)

    Williams, Stephen P; Howe, Christopher L

    2013-01-01

    Perhaps individual wishes are not always acknowledged or accepted when it comes to end-of-life care. This possibility, in conjunction with the experiences of healthcare risk managers, should cause concern in the healthcare risk management community. One particularly concerning issue where a persistent failure to honor a patient's wishes exists is with Do Not Resuscitate (DNR) orders in the perioperative arena. Despite a strong focus on informed consent and advance directives, evidence suggests a number of healthcare organizations either have no policy in place regarding DNR orders during the perioperative period, or, for those organizations that do have a policy, many call for automatic suspension of the DNR order without consultation with the patient. This latter practice poses many ethical, medico-legal, and regulatory concerns, and healthcare organizations with such a policy in place should strongly consider revisiting this practice. PMID:23609975

  12. Advances in solar photoelectro-Fenton: Decolorization and mineralization of the Direct Yellow 4 diazo dye using an autonomous solar pre-pilot plant

    International Nuclear Information System (INIS)

    Highlights: • Assessment of an autonomous solar pre-pilot plant for solar photoelectro-Fenton. • Total decolorization and 96-97% mineralization for solutions of Direct Yellow 4 diazo dye at pH 3.0. • More rapid dye decay and mineralization at 0.50 mmol dm−3 Fe2+ and maximum current of 5.0 A. • 11 aromatics, 22 hydroxylated derivatives and 9 carboxylic acids detected as intermediates. • Release of NH4+ and SO42−as main inorganic ions. - Abstract: Here, an overview on the advances in solar photoelectro-Fenton (SPEF) is initially presented to show that it is the more potent electrochemical advanced oxidation process based on Fenton's reaction chemistry to remove organic pollutants from waters, due to the synergistic action of generated hydroxyl radicals and solar irradiation. As a novel advance for SPEF, an autonomous solar pre-pilot plant is proposed to make an energetically inexpensive process that can be viable at industrial level. The plant of 10 dm3 capacity contained a Pt/air-diffusion cell with 90.2 cm2 electrode area, coupled to a solar compound parabolic collectors (CPCs) photoreactor of 1.57 dm3 irradiation volume and to a solar photovoltaic panel that provides a maximum average current of 5.0 A. The oxidation ability of this plant was assessed by studying the degradation of Direct Yellow 4 (DY4) diazo dye, which involved the predominant destruction of organics by ·OH formed from Fenton's reaction between H2O2 generated at the cathode and added Fe2+, along with the photolysis of Fe(III)-carboxylate complexes with sunlight in the CPCs photoreactor. The effect of Fe2+ and dye contents as well as current on decolorization rate, substrate decay and mineralization rate was examined. About 96-97% mineralization was rapidly attained using 0.50 mmol dm−3 Fe2+ and up to 0.32 mmol dm−3 DY4 at 5.0 A. The DY4 decay always obeyed a pseudo-first-order kinetics. Eleven aromatic products, twenty two hydroxylated derivatives and nine short

  13. An overview on the advanced oxidation processes applied for the treatment of water pollutants defined in the recently launched Directive 2013/39/EU.

    Science.gov (United States)

    Ribeiro, Ana R; Nunes, Olga C; Pereira, Manuel F R; Silva, Adrián M T

    2015-02-01

    Environmental pollution is a recognized issue of major concern since a wide range of contaminants has been found in aquatic environment at ngL(-1) to μgL(-1) levels. In the year 2000, a strategy was defined to identify the priority substances concerning aquatic ecosystems, followed by the definition of environmental quality standards (EQS) in 2008. Recently it was launched the Directive 2013/39/EU that updates the water framework policy highlighting the need to develop new water treatment technologies to deal with such problem. This review summarizes the data published in the last decade regarding the application of advanced oxidation processes (AOPs) to treat priority compounds and certain other pollutants defined in this Directive, excluding the inorganic species (cadmium, lead, mercury, nickel and their derivatives). The Directive 2013/39/EU includes several pesticides (aldrin, dichlorodiphenyltrichloroethane, dicofol, dieldrin, endrin, endosulfan, isodrin, heptachlor, lindane, pentachlorophenol, chlorpyrifos, chlorfenvinphos, dichlorvos, atrazine, simazine, terbutryn, diuron, isoproturon, trifluralin, cypermethrin, alachlor), solvents (dichloromethane, dichloroethane, trichloromethane and carbon tetrachloride), perfluorooctane sulfonic acid and its derivatives (PFOS), polychlorinated biphenyls (PCBs), polycyclic aromatic hydrocarbons (PAHs), nonylphenol and octylphenol, as well as the three compounds included in the recommendation for the first watch list of substances (diclofenac, 17-alpha-ethinylestradiol (EE2) and 17-beta-estradiol (E2)). Some particular pesticides (aclonifen, bifenox, cybutryne, quinoxyfen), organotin compounds (tributyltin), dioxins and dioxin-like compounds, brominated diphenylethers, hexabromocyclododecanes and di(2-ethylhexyl)phthalate are also defined in this Directive, but studies dealing with AOPs are missing. AOPs are recognized tools to destroy recalcitrant compounds or, at least, to transform them into biodegradable species

  14. Rigid Bodies in Contact

    DEFF Research Database (Denmark)

    Niebe, Sarah Maria

    The topic of this thesis is the numerics of rigid body simulation, with focus on the contact force problem. Three contact force models are presented, followed by three contact point determination methods. To solve the contact force problem, six different numerical methods are presented, each...... tailored to solve problems in the form of one of the three contact force models. The scientific contributions of this thesis, lies in part in the dissection of existing methods in which issues are uncovered and – where possible – fixes are suggested, and in part in the development of novel methods. A...... contact point determination method, based on boolean surface maps, is developed to handle collisions between tetrahedral meshes. The novel nonsmooth nonlinear conjugate gradient (NNCG) method is presented. The NNCG method is comparable in terms of accuracy to the state-of-the-art method, projected Gauss...

  15. Contact resistance evolution of highly cycled, lightly loaded micro-contacts

    Science.gov (United States)

    Stilson, Christopher; Coutu, Ronald

    2014-03-01

    Reliable microelectromechanical systems (MEMS) switches are critical for developing high performance radio frequency circuits like phase shifters. Engineers have attempted to improve reliability and lifecycle performance using novel contact metals, unique mechanical designs and packaging. Various test fixtures including: MEMS devices, atomic force microscopes (AFM) and nanoindentors have been used to collect resistance and contact force data. AFM and nanoindentor test fixtures allow direct contact force measurements but are severely limited by low resonance sensors, and therefore low data collection rates. This paper reports the contact resistance evolution results and fabrication of thin film, sputtered and evaporated gold, micro-contacts dynamically tested up to 3kHz. The upper contact support structure consists of a gold surface micromachined, fix-fix beam designed with sufficient restoring force to overcome adhesion. The hemisphere-upper and planar-lower contacts are mated with a calibrated, external load resulting in approximately 100μN of contact force and are cycled in excess of 106 times or until failure. Contact resistance is measured, in-situ, using a cross-bar configuration and the entire apparatus is isolated from external vibration and housed in an enclosure to minimize contamination due to ambient environment. Additionally, contact cycling and data collection are automated using a computer and LabVIEW. Results include contact resistance measurements of 6 and 8 μm radius contact bumps and lifetime testing up to 323.6 million cycles.

  16. Using SpaceClaimTD Direct for Modeling Components with Complex Geometries for the Thermal Desktop-Based Advanced Stirling Radioisotope Generator Model

    Science.gov (United States)

    Fabanich, William A., Jr.

    2014-01-01

    SpaceClaim/TD Direct has been used extensively in the development of the Advanced Stirling Radioisotope Generator (ASRG) thermal model. This paper outlines the workflow for that aspect of the task and includes proposed best practices and lessons learned. The ASRG thermal model was developed to predict component temperatures and power output and to provide insight into the prime contractor's thermal modeling efforts. The insulation blocks, heat collectors, and cold side adapter flanges (CSAFs) were modeled with this approach. The model was constructed using mostly TD finite difference (FD) surfaces/solids. However, some complex geometry could not be reproduced with TD primitives while maintaining the desired degree of geometric fidelity. Using SpaceClaim permitted the import of original CAD files and enabled the defeaturing/repair of those geometries. TD Direct (a SpaceClaim add-on from CRTech) adds features that allowed the "mark-up" of that geometry. These so-called "mark-ups" control how finite element (FE) meshes are to be generated through the "tagging" of features (e.g. edges, solids, surfaces). These tags represent parameters that include: submodels, material properties, material orienters, optical properties, and radiation analysis groups. TD aliases were used for most tags to allow analysis to be performed with a variety of parameter values. "Domain-tags" were also attached to individual and groups of surfaces and solids to allow them to be used later within TD to populate objects like, for example, heaters and contactors. These tools allow the user to make changes to the geometry in SpaceClaim and then easily synchronize the mesh in TD without having to redefine the objects each time as one would if using TDMesher. The use of SpaceClaim/TD Direct helps simplify the process for importing existing geometries and in the creation of high fidelity FE meshes to represent complex parts. It also saves time and effort in the subsequent analysis.

  17. Using SpaceClaim/TD Direct for Modeling Components with Complex Geometries for the Thermal Desktop-Based Advanced Stirling Radioisotope Generator Model

    Science.gov (United States)

    Fabanich, William

    2014-01-01

    SpaceClaim/TD Direct has been used extensively in the development of the Advanced Stirling Radioisotope Generator (ASRG) thermal model. This paper outlines the workflow for that aspect of the task and includes proposed best practices and lessons learned. The ASRG thermal model was developed to predict component temperatures and power output and to provide insight into the prime contractors thermal modeling efforts. The insulation blocks, heat collectors, and cold side adapter flanges (CSAFs) were modeled with this approach. The model was constructed using mostly TD finite difference (FD) surfaces solids. However, some complex geometry could not be reproduced with TD primitives while maintaining the desired degree of geometric fidelity. Using SpaceClaim permitted the import of original CAD files and enabled the defeaturing repair of those geometries. TD Direct (a SpaceClaim add-on from CRTech) adds features that allowed the mark-up of that geometry. These so-called mark-ups control how finite element (FE) meshes were generated and allowed the tagging of features (e.g. edges, solids, surfaces). These tags represent parameters that include: submodels, material properties, material orienters, optical properties, and radiation analysis groups. TD aliases were used for most tags to allow analysis to be performed with a variety of parameter values. Domain-tags were also attached to individual and groups of surfaces and solids to allow them to be used later within TD to populate objects like, for example, heaters and contactors. These tools allow the user to make changes to the geometry in SpaceClaim and then easily synchronize the mesh in TD without having to redefine these objects each time as one would if using TD Mesher.The use of SpaceClaim/TD Direct has helped simplify the process for importing existing geometries and in the creation of high fidelity FE meshes to represent complex parts. It has also saved time and effort in the subsequent analysis.

  18. Eldercare at Home: Advanced Directives

    Science.gov (United States)

    ... which means someone who has the authority to act for another person. (Other terms that refer to the same role ... included in the medical record if the older person is admitted to a hospital or skilled ... Act, patients or their representatives will be asked if ...

  19. Nurses’ perceptions of advance directives

    Directory of Open Access Journals (Sweden)

    Ernestina Silva

    2014-11-01

    Conclusion: Nurses have little experience with AD. They are available to respect the patient's will but did not feel able to address the issue on their own initiative. Most agree that the AD can “fail” if the patient does not reevaluate it periodically. Reflection and debate on the ethical issues surrounding AD should be promoted: promoting patient autonomy, care in vulnerable situations, team decisions and conscientious objection.

  20. Sutures and contact homology I

    OpenAIRE

    Colin, Vincent; Ghiggini, Paolo; Honda, Ko; Hutchings, Michael

    2010-01-01

    We define a relative version of contact homology for contact manifolds with convex boundary, and prove basic properties of this relative contact homology. Similar considerations also hold for embedded contact homology.

  1. Contact Hamiltonian Mechanics

    CERN Document Server

    Bravetti, Alessandro; Tapias, Diego

    2016-01-01

    In this work we introduce contact Hamiltonian mechanics, an extension of symplectic Hamiltonian mechanics, and show that it is a natural candidate for a geometric description of non-dissipative and dissipative systems. For this purpose we review in detail the major features of standard symplectic Hamiltonian dynamics and show that all of them can be generalized to the contact case.

  2. Contact dermatitis. A review

    DEFF Research Database (Denmark)

    Andersen, Klaus Ejner; Benezra, C; Burrows, D;

    1987-01-01

    In recent years, there has been a dramatic rise in our understanding of contact dermatitis. This paper is a review of our knowledge of the mechanisms involved in contact dermatitis and related phenomena, the investigation of these events and the emergence of significant new allergens during the...

  3. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... I had not been properly fitted by an eye care professional, the lenses stuck to my eye like a suction cup." ... lenses, costume contacts can certainly add a spooky, eye-popping touch. But colored contact lenses are popular year-round, not just at Halloween. ...

  4. Superconducting quantum point contacts

    Science.gov (United States)

    Bretheau, L.; Girit, Ç.; Tosi, L.; Goffman, M.; Joyez, P.; Pothier, H.; Esteve, D.; Urbina, C.

    2012-01-01

    We review our experiments on the electronic transport properties of atomic contacts between metallic electrodes, in particular superconducting ones. Despite ignorance of the exact atomic configuration, these ultimate quantum point contacts can be manipulated and well characterized in-situ. They allow performing fundamental tests of the scattering theory of quantum transport. In particular, we discuss the case of the Josephson effect.

  5. Superconducting Quantum Point Contacts

    OpenAIRE

    Bretheau, L.; Girit, Ç.; Tosi, L.; Goffman, M.; Joyez, P.; Pothier, H.; Esteve, D.; Urbina, C.

    2012-01-01

    We review our experiments on the electronic transport properties of atomic contacts between metallic electrodes, in particular superconducting ones. Despite ignorance of the exact atomic configuration, these ultimate quantum point contacts can be manipulated and well characterized in-situ. They allow performing fundamental tests of the scattering theory of quantum transport. In particular, we discuss the case of the Josephson effect.

  6. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... Halloween Hazard: The Hidden Dangers of Buying Decorative Contact Lenses Without a Prescription Sep. 26, 2013 It started ... vampire eyes to glow-in-the-dark lizard lenses, costume contacts can certainly add a spooky, eye-popping touch. ...

  7. Contact materials for nanoelectronics

    KAUST Repository

    Alshareef, Husam N.

    2011-02-01

    In this article, we review current research activities in contact material development for electronic and nanoelectronic devices. A fundamental issue in contact materials research is to understand and control interfacial reactions and phenomena that modify the expected device performance. These reactions have become more challenging and more difficult to control as new materials have been introduced and as device sizes have entered the deep nanoscale. To provide an overview of this field of inquiry, this issue of MRS Bulletin includes articles on gate and contact materials for Si-based devices, junction contact materials for Si-based devices, and contact materials for alternate channel substrates (Ge and III-V), nanodevices. © 2011 Materials Research Society.

  8. Recent Trends in Occupational Contact Dermatitis.

    Science.gov (United States)

    Wiszniewska, Marta; Walusiak-Skorupa, Jolanta

    2015-07-01

    Occupational contact dermatitis (OCD) remains prevalent among workers and impacts quality of life and workability. The purpose of this review is to summarize the recent advances in occupational contact dermatitis as well as potential hazardous agents in the workplaces causing OCD. The review covers new developments in the epidemiology, etiology, diagnosis, and management of occupational contact dermatitis. This article also provides updated information on the prevalence of work-related skin symptoms and on new contact allergens among working population. It is emphasized that in the context of prevention of OCD, special attention should be focused on the identified high-risk occupational groups, especially healthcare workers and hairdressers starting with the apprentices. Current approaches include working out the standards and guidelines to improve the education, knowledge, diagnosis, and management of OCD based on a multidisciplinary team of medical specialists and an employer. PMID:26143395

  9. Quantized conductance in an atom-sized point contact

    DEFF Research Database (Denmark)

    Olesen, L.; Laegsgaard, E.; Stensgaard, I.; Besenbacher, Flemming; Schiøtz, Jakob; Stoltze, Per; Jacobsen, Karsten Wedel; Nørskov, Jens Kehlet

    1994-01-01

    We present direct measurements at room temperature of the conductance of a point contact between a scanning tunneling microscope tip and Ni, Cu, and Pt surfaces. As the contact is stretched the conductance jumps in units of 2e2/h. Atomistic simulations of the stretch of the contact combined with...

  10. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... Center Global Ophthalmology Guide Find an Ophthalmologist Advanced Search Annual Meeting Clinical Education Practice Management Member Services ... Center Global Ophthalmology Guide Find an Ophthalmologist Advanced ... Subspecialties Cataract/Anterior Segment Comprehensive Ophthalmology Cornea/External ...

  11. Computational contact mechanics

    CERN Document Server

    Wriggers, Peter

    2006-01-01

    Contact mechanics has its application in many engineering problems. No one can walk without frictional contact, and no car would move for the same r- son. Hence contact mechanics has, from an engineering point of view, a long history, beginning in ancient Egypt with the movement of large stone blocks, over ?rst experimental contributions from leading scientists like Leonardo da Vinci andCoulomb, to today's computational methods. In the past c- tact conditions were often modelled in engineering analysis by more simple boundary conditions since analytical solutions were not present for real worl

  12. Asynchronous Variational Contact Mechanics

    CERN Document Server

    Vouga, Etienne; Tamstorf, Rasmus; Grinspun, Eitan

    2010-01-01

    An asynchronous, variational method for simulating elastica in complex contact and impact scenarios is developed. Asynchronous Variational Integrators (AVIs) are extended to handle contact forces by associating different time steps to forces instead of to spatial elements. By discretizing a barrier potential by an infinite sum of nested quadratic potentials, these extended AVIs are used to resolve contact while obeying momentum- and energy-conservation laws. A series of two- and three-dimensional examples illustrate the robustness and good energy behavior of the method.

  13. Model calculation and analysis of heat and mass transfer of air and water in direct contact counter flow%空气与水逆流直接接触热质交换过程模型计算及分析

    Institute of Scientific and Technical Information of China (English)

    宋垚臻

    2005-01-01

    Based on reasonable model hypotheses and the energy analysis of heat and mass transfer of air and water in a direct contact counter flow, a set of general equations that can describe the internal relationship between the state parameters of air and water and dimensionless parameters of transfer process are given. A method utilizing MATLAB to solve these general equations is also proposed. Calculations and analysis with the model of a cooling- dehumidifying process give a consistent result with that of previous experiment. A new method for designing equipment such as evaporating cooler and cooling tower, and for analyzing experiment data of heat and mass transfer of air and water in a direct contact counter flow can be derived from this study.

  14. High Tc superconductors and the contact properties

    OpenAIRE

    Huang, Hua; Grovenor, C.; Dr. C. R. M. Grovenor

    1992-01-01

    Methods of processing large grained textured superconductor have been successfully developed, based on a melt texturing process. Large grained textured superconductor with grain size over 10mm along the growth direction and Jc over 3600A/cm2 (77K, 0.5 Tesla) has been produced in both one - zone and two - zone furnaces with good reproducibility. Two kinds of design of reactive metal contacts have been proposed and investigated, aiming to make low resistivity contacts with st...

  15. Quantitative non contact dynamic Casimir force measurements

    OpenAIRE

    Jourdan, Guillaume; Lambrecht, Astrid; Comin, Fabio; Chevrier, Joël

    2009-01-01

    We show that the Casimir force gradient can be quantitatively measured with no contact involved. Results of the Casimir force measurement with systematic uncertainty of 3% are presented for the distance range of 100-600 nm. The statistical uncertainty is shown to be due to the thermal fluctuations of the force probe. The corresponding signal to noise ratio equals unity at the distance of 600 nm. Direct contact between surfaces used in most previous studies to determine absolute distance separ...

  16. Directional self-cleaning superoleophobic surface.

    Science.gov (United States)

    Zhao, Hong; Law, Kock-Yee

    2012-08-14

    In this work, we report the creation of a grooved surface comprising 3 μm grooves (height ~4 μm) separated by 3 μm from each other on a silicon wafer by photolithography. The grooved surface was then modified chemically with a fluorosilane layer (FOTS). The surface property was studied by both static and dynamic contact angle measurements using water, hexadecane, and a polyethylene wax ink as the probing liquids. Results show that the grooved surface is both superhydrophobic and superoleophobic. Its observed contact angles agree well with the calculated Cassie-Baxter angles. More importantly, we are able to make a replica of the composite wax ink-air interface and study it by SEM. Microscopy results not only show that the droplet of the wax ink "sits" on air in the composite interface but also further reveal that the ink drop actually pins underneath the re-entrant structure in the side wall of the grooved structure. Contact angle measurement results indicate that wetting on the grooved surface is anisotropic. Although liquid drops are found to have lower static and advancing contact angles in the parallel direction, the drops are found to be more mobile, showing smaller hysteresis and lower sliding angles (as compared to the FOTS wafer surface and a comparable 3-μm-diameter pillar array FOTS surface). The enhanced mobility is attributable to the lowering of the resistance against an advancing liquid because 50% of the advancing area is made of a solid strip where the liquid likes to wet. This also implies that the contact line for advancing is no longer smooth but rather is ragged, having the solid strip area leading the wetting and the air strip area trailing behind. This interpretation is supported by imaging the geometry of the contact lines using molten ink drops recovered from the sliding angle experiments in both the parallel and orthogonal directions. Because the grooved surface is mechanically stronger against mechanical abrasion, the self

  17. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... also available in Spanish . Follow The Academy Professionals: Education Guidelines News Multimedia Public & Patients: Contact Us About the Academy Jobs at the Academy Financial Relationships with Industry Medical ...

  18. Colored Contact Lens Dangers

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  19. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... be purchased over-the-counter or on the Internet," says Thomas Steinemann, MD, professor of ophthalmology at ... ask for a prescription. There is no such thing as a "one size fits all" contact lens. ...

  20. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... Many of the lenses found online or in beauty salons, novelty shops or in pop-up Halloween ... in the United States. Related Stories Are six-month contact lenses purchased in Korea safe? May 13, ...

  1. Occupational Contact Dermatitis

    Directory of Open Access Journals (Sweden)

    Sasseville Denis

    2008-06-01

    Full Text Available Occupational contact dermatitis accounts for 90% of all cases of work-related cutaneous disorders. It can be divided into irritant contact dermatitis, which occurs in 80% of cases, and allergic contact dermatitis. In most cases, both types will present as eczematous lesions on exposed parts of the body, notably the hands. Accurate diagnosis relies on meticulous history taking, thorough physical examination, careful reading of Material Safety Data Sheets to distinguish between irritants and allergens, and comprehensive patch testing to confirm or rule out allergic sensitization. This article reviews the pathogenesis and clinical manifestations of occupational contact dermatitis and provides diagnostic guidelines and a rational approach to management of these often frustrating cases.

  2. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... Follow The Academy Professionals: Education Guidelines News Multimedia Public & Patients: Contact Us About the Academy Jobs at the Academy Financial Relationships with Industry Medical Disclaimer Privacy Policy Terms of Service For Advertisers For Media Ophthalmology ...

  3. Colored Contact Lens Dangers

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    Full Text Available ... had not been properly fitted by an eye care professional, the lenses stuck to my eye like ... lenses do not require the same level of care or consideration as a standard contact lens because ...

  4. Colored Contact Lens Dangers

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  5. Colored Contact Lens Dangers

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  6. Colored Contact Lens Dangers

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  7. Colored Contact Lens Dangers

    Medline Plus

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  8. Colored Contact Lens Dangers

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  9. Colored Contact Lens Dangers

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  10. Colored Contact Lens Dangers

    Medline Plus

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  11. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... lenses do not require the same level of care or consideration as a standard contact lens because they can be purchased over-the-counter or on the Internet," says Thomas Steinemann, MD, professor of ophthalmology at ...

  12. On Contact Anosov Flows

    OpenAIRE

    Carlangelo, Liverani

    2003-01-01

    Exponential decay of correlations for $\\Co^{(4)}$ Contact Anosov flows is established. This implies, in particular, exponential decay of correlations for all smooth geodesic flows in strictly negative curvature.

  13. Acoustoconductance of quantum contacts

    OpenAIRE

    Blencowe, M. P.; Shik, A. Y.

    1998-01-01

    We describe theoretically the acoustoconductance (AC) of quantum contacts. One characteristic of a contact which distinguishes it from a long, uniform wire is a strong, energy-dependent transmission probability. This has several consequences for AC. Electrons which are forward scattered by phonons can contribute to AC and, furthermore, AC can have positive sign (i.e. a conductance-increase under the influence of phonons). By contrast, for uniform wires only backscattered electrons contribute ...

  14. Pediatric contact dermatitis

    OpenAIRE

    Sharma Vinod; Asati Dinesh

    2010-01-01

    Allergic contact dermatitis (ACD) in children, until recently, was considered rare. ACD was considered as a disorder of the adult population and children were thought to be spared due to a lack of exposure to potential allergens and an immature immune system. Prevalence of ACD to even the most common allergens in children, like poison ivy and parthenium, is relatively rare as compared to adults. However, there is now growing evidence of contact sensitization of the pediatric population, and i...

  15. Harmonic almost contact structures

    OpenAIRE

    Vergara-Diaz, E.; Wood, C. M.

    2006-01-01

    An almost contact metric structure is parametrized by a section of an associated homogeneous fibre bundle, and conditions for this to be a harmonic section, and a harmonic map, are studied. These involve the characteristic vector field, and the almost complex structure in the contact subbundle. Several examples are given where the harmonic section equations reduce to those for the characteristic field to be a harmonic section of the unit tangent bundle. These include trans-Sasakian structures...

  16. Point-Contact Spectroscopy

    CERN Document Server

    Naidyuk, Yu G; Naidyuk, Yu. G.

    2003-01-01

    The history is described of how one of the most commonly used electric circuit components, an ordinary electric contact, has become a powerful tool for the physicists to study various mechanisms of electron scattering in metals. The physical principles of spectroscopy of quasi-particle excitations in metals by means of point contacts (PCs) whose dimensions range from only a few to tens of nanometers are presented in a popular form.

  17. Advanced Condenser Boosts Geothermal Power Plant Output (Fact Sheet), The Spectrum of Clean Energy Innovation

    Energy Technology Data Exchange (ETDEWEB)

    2010-12-01

    When power production at The Geysers geothermal power complex began to falter, the National Renewable Energy Laboratory (NREL) stepped in, developing advanced condensing technology that dramatically boosted production efficiency - and making a major contribution to the effective use of geothermal power. NREL developed advanced direct-contact condenser (ADCC) technology to condense spent steam more effectively, improving power production efficiency in Unit 11 by 5%.

  18. Lettuce contact allergy.

    Science.gov (United States)

    Paulsen, Evy; Andersen, Klaus E

    2016-02-01

    Lettuce (Lactuca sativa L.) and its varieties are important vegetable crops worldwide. They are also well-known, rarely reported, causes of contact allergy. As lettuce allergens and extracts are not commercially available, the allergy may be underdiagnosed. The aims of this article are to present new data on lettuce contact allergy and review the literature. Lettuce is weakly allergenic, and occupational cases are mainly reported. Using aimed patch testing in Compositae-allergic patients, two recent Danish studies showed prevalence rates of positive lettuce reactions of 11% and 22%. The majority of cases are non-occupational, and may partly be caused by cross-reactivity. The sesquiterpene lactone mix seems to be a poor screening agent for lettuce contact allergy, as the prevalence of positive reactions is significantly higher in non-occupationally sensitized patients. Because of the easy degradability of lettuce allergens, it is recommended to patch test with freshly cut lettuce stem and supplement this with Compositae mix. As contact urticaria and protein contact dermatitis may present as dermatitis, it is important to perform prick-to-prick tests, and possibly scratch patch tests as well. Any person who is occupationally exposed to lettuce for longer periods, especially atopics, amateur gardeners, and persons keeping lettuce-eating pets, is potentially at risk of developing lettuce contact allergy. PMID:26289653

  19. Double pendulum contact problem

    Directory of Open Access Journals (Sweden)

    Špička J.

    2014-06-01

    Full Text Available The work concerns contact problems focused on biomechanical systems modelled by a multibody approach. The example is modelling of impact between a body and an infrastructure. The paper firstly presents algorithm for minimum distance calculation. An analytical approach using a tangential plain perpendicular to an initial one is applied. Contact force generated during impact is compared by three different continuous force models, namely the Hertz’s model, the spring-dashpot model and the non-linear damping model. In order to identify contact parameters of these particular models, the method of numerical optimization is used. Purpose of this method is to find the most corresponding results of numerical simulation to the original experiment. Numerical optimization principle is put upon a bouncing ball example for the purpose of evaluation of desirable contact force parameters. The contact modelling is applied to a double pendulum problem. The equation of motion of the double pendulum system is derived using Lagrange equation of the second kind with multipliers, respecting the contact phenomena. Applications in biomechanical research are hinted at arm gravity motion and a double pendulum impact example.

  20. Contact processes in crowded environments.

    Science.gov (United States)

    Xu, S-L-Y; Schwarz, J M

    2013-11-01

    Periodically sheared colloids at low densities demonstrate a dynamical phase transition from an inactive to active phase as the strain amplitude is increased. The inactive phase consists of no collisions (contacts) between particles in the steady state limit, while in the active phase collisions persist. To investigate this system at higher densities, we construct and study a conserved-particle-number contact process with three-body interactions, which are potentially more likely than two-body interactions at higher densities. For example, consider one active (diffusing) particle colliding with two inactive (nondiffusing) particles such that they become active and consider spontaneous inactivation. In mean field, this system exhibits a continuous dynamical phase transition. Simulations on square lattices also indicate a continuous transition with exponents similar to those measured for the conserved lattice gas (CLG) model. In contrast, the three-body interaction requiring two active particles to activate one inactive particle exhibits a discontinuous transition. Finally, inspired by kinetically constrained models of the glass transition, we investigate the "caging effect" at even higher particle densities to look for a second dynamical phase transition back to an inactive phase. Square lattice simulations suggest a continuous transition with a new set of exponents differing from both the CLG model and what is known as directed percolation, indicating a potentially new universality class for a contact process with a conserved particle number. PMID:24329237

  1. Topological contact dynamics II: topological automorphisms, contact homeomorphisms, and non-smooth contact dynamical systems

    OpenAIRE

    Müller, Stefan; Spaeth, Peter

    2012-01-01

    This sequel to our previous paper [MS11b] continues the study of topological contact dynamics and applications to contact dynamics and topological dynamics. We provide further evidence that the topological automorphism groups of a contact structure and a contact form are the appropriate transformation groups of contact dynamical systems. The article includes an examination of the groups of time-one maps of topological contact and strictly contact isotopies, and the construction of a bi-invari...

  2. Local address and emergency contact details

    CERN Multimedia

    2013-01-01

    The HR Department would like to remind members of the personnel that they are responsible for ensuring that their personal data concerning local address and preferred emergency contact details remains valid and up-to-date.   Both are easily accessible via the links below: Local address: https://edh.cern.ch/Document/Personnel/LocalAddressChange   Emergency contacts: https://edh.cern.ch/Document/Personnel/EC   Please take a few minutes to check your details and modify if necessary. Thank you in advance. HR Department Head Office

  3. Contact Thermocouple Methodology and Evaluation for Temperature Measurement in the Laboratory

    Science.gov (United States)

    Brewer, Ethan J.; Pawlik, Ralph J.; Krause, David L.

    2013-01-01

    Laboratory testing of advanced aerospace components very often requires highly accurate temperature measurement and control devices, as well as methods to precisely analyze and predict the performance of such components. Analysis of test articles depends on accurate measurements of temperature across the specimen. Where possible, this task is accomplished using many thermocouples welded directly to the test specimen, which can produce results with great precision. However, it is known that thermocouple spot welds can initiate deleterious cracks in some materials, prohibiting the use of welded thermocouples. Such is the case for the nickel-based superalloy MarM-247, which is used in the high temperature, high pressure heater heads for the Advanced Stirling Converter component of the Advanced Stirling Radioisotope Generator space power system. To overcome this limitation, a method was developed that uses small diameter contact thermocouples to measure the temperature of heater head test articles with the same level of accuracy as welded thermocouples. This paper includes a brief introduction and a background describing the circumstances that compelled the development of the contact thermocouple measurement method. Next, the paper describes studies performed on contact thermocouple readings to determine the accuracy of results. It continues on to describe in detail the developed measurement method and the evaluation of results produced. A further study that evaluates the performance of different measurement output devices is also described. Finally, a brief conclusion and summary of results is provided.

  4. Eye Contact Facilitates Awareness of Faces during Interocular Suppression

    Science.gov (United States)

    Stein, Timo; Senju, Atsushi; Peelen, Marius V.; Sterzer, Philipp

    2011-01-01

    Eye contact captures attention and receives prioritized visual processing. Here we asked whether eye contact might be processed outside conscious awareness. Faces with direct and averted gaze were rendered invisible using interocular suppression. In two experiments we found that faces with direct gaze overcame such suppression more rapidly than…

  5. Tomato contact dermatitis

    DEFF Research Database (Denmark)

    Paulsen, Evy; Christensen, Lars P; Andersen, Klaus Ejner

    2012-01-01

    plants and review the literature on contact dermatitis caused by both plants and fruits. An ether extract of tomato plants made as the original oleoresin plant extracts, was used in aimed patch testing, and between 2005 and 2011. 8 of 93 patients (9%) tested positive to the oleoresin extracts. This...... caused by tomato plants and fruit may be established with the use of ether extracts and fresh fruits, respectively.......The tomato plant (Solanum lycopersicum) is an important crop worldwide. Whereas immediate-type reactions to tomato fruits are well known, contact dermatitis caused by tomatoes or tomato plants is rarely reported. The aims of this study were to present new data on contact sensitization to tomato...

  6. Shoe allergic contact dermatitis.

    Science.gov (United States)

    Matthys, Erin; Zahir, Amir; Ehrlich, Alison

    2014-01-01

    Foot dermatitis is a widespread condition, affecting men and women of all ages. Because of the location, this condition may present as a debilitating problem to those who have it. Allergic contact dermatitis involving the feet is frequently due to shoes or socks. The allergens that cause shoe dermatitis can be found in any constituent of footwear, including rubber, adhesives, leather, dyes, metals, and medicaments. The goal of treatment is to identify and minimize contact with the offending allergen(s). The lack of product information released from shoe manufacturers and the continually changing trends in footwear present a challenge in treating this condition. The aim of this study is to review the current literature on allergic contact shoe dermatitis; clinical presentation, allergens, patch testing, and management will be discussed. PubMed and MEDLINE databases were used for the search, with a focus on literature updates from the last 15 years. PMID:25000234

  7. ALLERGIC CONTACT DERMATITIS

    Directory of Open Access Journals (Sweden)

    Trisna Yuliharti Tersinanda

    2013-07-01

    Full Text Available Normal 0 false false false EN-US X-NONE X-NONE Allergic contact dermatitis is an immunologic reaction that tends to involve the surrounding skin and may even spread beyond affected sites. This skin disease is one of the more frequent, and costly dermatologic problems. Recent data from United Kingdom and United States suggest that the percentage of occupational contact dermatitis due to allergy may be much higher, thus raising the economic impact of occupational allergic contact dermatitis. There is not enough data about the epidemiology of allergic contact dermatitis in Indonesia, however based on research that include beautician in Denpasar, about 27,6 percent had side effect of cosmetics, which is 25,4 percent of it manifested as allergic contact dermatitis. Diagnosis of allergic contact dermatitis is based on anamnesis, physical examination, patch test, and this disease should be distinguished from other eczematous skin disease. The management is prevention of allergen exposure, symptomatic treatment, and physicochemical barrier /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:"Times New Roman"; mso-bidi-theme-font:minor-bidi;}

  8. Weight gain is associated with medial contact site of subthalamic stimulation in Parkinson's disease.

    Directory of Open Access Journals (Sweden)

    Filip Růžička

    Full Text Available The aim of our study was to assess changes in body-weight in relation to active electrode contact position in the subthalamic nucleus. Regular body weight measurements were done in 20 patients with advanced Parkinson's disease within a period of 18 months after implantation. T1-weighted (1.5T magnetic resonance images were used to determine electrode position in the subthalamic nucleus and the Unified Parkinson's disease rating scale (UPDRS-III was used for motor assessment. The distance of the contacts from the wall of the third ventricle in the mediolateral direction inversely correlated with weight gain (r = -0.55, p<0.01 and with neurostimulation-related motor condition expressed as the contralateral hemi-body UPDRS-III (r = -0.42, p<0.01. Patients with at least one contact within 9.3 mm of the wall experienced significantly greater weight gain (9.4 ± (SD4.4 kg, N = 11 than those with both contacts located laterally (3.9 ± 2.7 kg, N = 9 (p<0.001. The position of the active contact is critical not only for motor outcome but is also associated with weight gain, suggesting a regional effect of subthalamic stimulation on adjacent structures involved in the central regulation of energy balance, food intake or reward.

  9. Theory of reciprocating contact for viscoelastic solids

    Science.gov (United States)

    Putignano, Carmine; Carbone, Giuseppe; Dini, Daniele

    2016-04-01

    A theory of reciprocating contacts for linear viscoelastic materials is presented. Results are discussed for the case of a rigid sphere sinusoidally driven in sliding contact with a viscoelastic half-space. Depending on the size of the contact, the frequency and amplitude of the reciprocating motion, and on the relaxation time of the viscoelastic body, we establish that the contact behavior may range from the steady-state viscoelastic solution, in which traction forces always oppose the direction of the sliding rigid punch, to a more elaborate trend, which is due to the strong interaction between different regions of the path covered during the reciprocating motion. Practical implications span a number of applications, ranging from seismic engineering to biotechnology.

  10. Cylindrical contact homology of subcritical Stein-fillable contact manifolds

    OpenAIRE

    Yau, Mei-Lin

    2004-01-01

    We use contact handle decompositions and a stabilization process to compute the cylindrical contact homology of a subcritical Stein-fillable contact manifold with vanishing first Chern class, and show that it is completely determined by the homology of a subcritical Stein-filling of the contact manifold.

  11. Vanishing of the contact homology of overtwisted contact 3--manifolds

    OpenAIRE

    Yau, Mei-Lin

    2004-01-01

    We give a proof of, for the case of contact structures defined by global contact 1-forms, a Theorem stated by Eliashberg that for any overtwisted contact structure on a closed 3-manifold, its contact homology is 0. A different proof is also outlined in the appendix by Yakov Eliashberg.

  12. Molecular dynamics study of contact mechanics: contact area and interfacial separation from small to full contact

    OpenAIRE

    Yang, C; Persson, B. N. J.

    2007-01-01

    We report a molecular dynamics study of the contact between a rigid solid with a randomly rough surface and an elastic block with a flat surface. We study the contact area and the interfacial separation from small contact (low load) to full contact (high load). For small load the contact area varies linearly with the load and the interfacial separation depends logarithmically on the load. For high load the contact area approaches to the nominal contact area (i.e., complete contact), and the i...

  13. Lettuce contact allergy

    DEFF Research Database (Denmark)

    Paulsen, Evy; Andersen, Klaus E

    2016-01-01

    Lettuce (Lactuca sativa L.) and its varieties are important vegetable crops worldwide. They are also well-known, rarely reported, causes of contact allergy. As lettuce allergens and extracts are not commercially available, the allergy may be underdiagnosed. The aims of this article are to present...... person who is occupationally exposed to lettuce for longer periods, especially atopics, amateur gardeners, and persons keeping lettuce-eating pets, is potentially at risk of developing lettuce contact allergy.......Lettuce (Lactuca sativa L.) and its varieties are important vegetable crops worldwide. They are also well-known, rarely reported, causes of contact allergy. As lettuce allergens and extracts are not commercially available, the allergy may be underdiagnosed. The aims of this article are to present...... new data on lettuce contact allergy and review the literature. Lettuce is weakly allergenic, and occupational cases are mainly reported. Using aimed patch testing in Compositae-allergic patients, two recent Danish studies showed prevalence rates of positive lettuce reactions of 11% and 22%. The...

  14. Have Confidence in Contact

    Science.gov (United States)

    Crisp, Richard J.; Turner, Rhiannon N.

    2010-01-01

    In an article in the May-June 2009 "American Psychologist," we discussed a new approach to reducing prejudice and encouraging more positive intergroup relations (Crisp & Turner, 2009). We named the approach imagined intergroup contact and defined it as "the mental simulation of a social interaction with a member or members of an outgroup category"…

  15. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... in the United States. All contact lenses are medical devices that require a prescription and proper fitting by ... do point to the importance of using digital devices smartly to avoid eye strain. Pet Fish Fitted with ... Relationships with Industry Medical Disclaimer Privacy Policy Terms of Service For Advertisers ...

  16. Language Contact and Bilingualism

    NARCIS (Netherlands)

    Appel, René; Muysken, Pieter

    2006-01-01

    What happens - sociologically, linguistically, educationally, politically - when more than one language is in regular use in a community? How do speakers handle these languages simultaneously, and what influence does this language contact have on the languages involved? Although most people in the w

  17. Colored Contact Lens Dangers

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  18. Colored Contact Lens Dangers

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  19. Colored Contact Lens Dangers

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  20. Colored Contact Lens Dangers

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    Full Text Available ... use of colored contact lenses , from the U.S. Food and Drug Administration (FDA). Are the colored lenses ... Cheryl terHorst On one of his regular mid-day swims, 78-year old Leroy Muffler noticed a ...

  1. Religious Allergic Contact Dermatitis.

    Science.gov (United States)

    Goldenberg, Alina; Matiz, Catalina; Eichenfield, Lawrence F

    2015-01-01

    Henna, derived from a combination of natural leaves and coloring additives, is a common decorative dye traditionally used in many Islamic religious celebrations. Para-phenylenediamine (PPD), a major component of black henna tattoo, is a strong sensitizer and common allergen. We report a case of severe connubial allergic contact dermatitis after black henna heterotransfer in a girl. PMID:25968562

  2. Induction of contact sensitivity

    International Nuclear Information System (INIS)

    Cells taken from the draining lymph nodes of mice 1 day after painting with picryl chloride can induce contact hypersensitivity when injected into the footpads of normal recipients. Footpad injection of 5 x 106 1-day draining lymph node cells induced a similar degree of hypersensitivity to the original skin painting with picryl chloride but no antibody, as judged by anti-TNP splenic PFC and serum antibody, in constrast to the moderate antibody response found after skin painting. The apprarent inability to induce a response did, however, correlate with the finding that the draining lymph nodes of mice painted with picryl chloride had few PFC. Some effect of the cells on antibody was noted in that after mice were challenged on the ear to produce contact sensitivity reactions they produced an antibody response larger than that of mice not injected with cells. This was not a large phenomenon but was unusual because 2.5 x 106 cells was more effective than either 106 or 5 x 106 cells, even though 5 x 106 cells produced the largest contact sensitivity reactions. The augmentation was antigen specific and the same dose-response effect could be obtained with irradiated cells (2000 rad). It is suggested that these cells may have an important role in the immunogenicity of contact sensitizing agents, which can induce large delayed-type hypersensitivity reactions accompanied only by moderate antibody responses. (author)

  3. Simulating frictional contact in smoothed particle hydrodynamics

    Institute of Scientific and Technical Information of China (English)

    WANG; Jian; WU; Hao; GU; ChongShi; HUA; Hui

    2013-01-01

    Smoothed Particle Hydrodynamics (SPH) is a powerful tool for large deformation computation of soil flow. However, the method to simulate frictional contact in the framework of SPH is still absent and needs to be developed. This paper presents an algorithm to simulate frictional contact between soil and rigid or deformable structure in the framework of SPH. In this algo-rithm, the computational domain is divided into several sub-domains according to the existing contact boundaries, and contact forces are used as bridges of these sub-domains to fulfill problem solving. In the process of the SPH discretization for govern-ing equation of each sub-domain, the inherent problem of boundary deficiency of SPH is handled properly. Therefore, the par-ticles located at contact boundary can have precise acceleration, which is critical for contact detection. Then, based on the as-sumption that the SPH particle of soil can slightly penetrate into the structure, the contact forces along normal and tangential directions of the contact surface are computed by momentum principle, and the frictional force is modified if sliding occurs.Compared with previous methods, in which only particle-to-particle contact is considered or frictional sliding is just ignored,the method proposed in this study is more efficient and accurate, and is suitable for simulating interaction between soft materi-als and rigid or deformable structures, which are very common in geotechnical engineering. A number of numerical tests have been carried out to verify the accuracy and stability of the proposed algorithm, and the results have been compared with ana-lytical solutions or FEM results. The consistency obtained from these comparisons indicates that the algorithm is robust and can enhance the computing capability of SPH.

  4. Duality based contact shape optimization

    DEFF Research Database (Denmark)

    Vondrák, Vít; Dostal, Zdenek; Rasmussen, John

    An implementation of semi-analytic method for the sensitivity analysis in contact shape optimization without friction is described. This method is then applied to the contact shape optimization.......An implementation of semi-analytic method for the sensitivity analysis in contact shape optimization without friction is described. This method is then applied to the contact shape optimization....

  5. Analysis of Wetting and Contact Angle Hysteresis on Chemically Patterned Surfaces

    KAUST Repository

    Xu, Xianmin

    2011-01-01

    Wetting and contact angle hysteresis on chemically patterned surfaces in two dimensionsare analyzed from a stationary phase-field model for immiscible two phase fluids. We first study the sharp-interface limit of the model by the method of matched asymptotic expansions. We then justify the results rigorously by the γ-convergence theory for the related variational problem and study the properties of the limiting minimizers. The results also provide a clear geometric picture of the equilibrium configuration of the interface. This enables us to explicitly calculate the total surface energy for the two phase systems on chemically patterned surfaces with simple geometries, namely the two phase flow in a channel and the drop spreading. By considering the quasi-staticmotion of the interface described by the change of volume (or volume fraction), we can follow the change-of-energy landscape which also reveals the mechanism for the stick-slip motion of the interface and contact angle hysteresis on the chemically patterned surfaces. As the interface passes throughpatterned surfaces, we observe not only stick-slip of the interface and switching of the contact angles but also the hysteresis of contact point and contact angle. Furthermore, as the size of the patternde creases to zero, the stick-slip becomes weaker but the hysteresis becomes stronger in the sense that one observes either the advancing contact angle or the receding contact angle (when the interface ismoving in the opposite direction) without the switching in between. © 2011 Society for Industrial and Applied Mathematics.

  6. Using a surrogate contact pair to evaluate polyethylene wear in prosthetic knee joints.

    Science.gov (United States)

    Sanders, Anthony P; Lockard, Carly A; Weisenburger, Joel N; Haider, Hani; Raeymaekers, Bart

    2016-01-01

    With recent improvements to the properties of ultra-high molecular weight polyethylene (UHMWPE) used in joint replacements, prosthetic knee and hip longevity may extend beyond two decades. However, it is difficult and costly to replicate such a long in vivo lifetime using clinically relevant in vitro wear testing approaches such as walking gait joint simulators. We advance a wear test intermediate in complexity between pin-on-disk and knee joint simulator tests. The test uses a surrogate contact pair, consisting of a surrogate femoral and tibial specimen that replicate the contact mechanics of any full-scale knee condyle contact pair. The method is implemented in a standard multi-directional pin-on-disk wear test machine, and we demonstrate its application via a two-million-cycle wear test of three different UHMWPE formulations. Further, we demonstrate the use of digital photography and image processing to accurately quantify fatigue damage based on the reduced transmission of light through a damage area in a UHMWPE specimen. The surrogate contact pairs replicate the knee condyle contact areas within -3% to +12%. The gravimetric wear test results reflect the dose of crosslinking radiation applied to the UHMWPE: 35 kGy yielded a wear rate of 7.4 mg/Mcycles, 55 kGy yielded 1.0 mg/Mcycles, and 75 kGy (applied to a 0.1% vitamin E stabilized UHMWPE) yielded 1.5 mg/Mcycles. A precursor to spalling fatigue is observed and precisely measured in the radiation-sterilized (35 kGy) and aged UHMWPE specimen. The presented techniques can be used to evaluate the high-cycle fatigue performance of arbitrary knee condyle contact pairs under design-specific contact stresses, using existing wear test machines. This makes the techniques more economical and well-suited to standardized comparative testing. PMID:25677393

  7. Colored Contact Lens Dangers

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  8. Colored Contact Lens Dangers

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  9. Colored Contact Lens Dangers

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    Full Text Available ... Guide Find an Ophthalmologist Advanced Search Annual Meeting Clinical Education Practice Management Member Services Advocacy Foundation About Subspecialties & More Eye Health Home Annual Meeting Clinical Education Practice Management Member Services Advocacy Foundation About ...

  10. Experimental Determination of Contact Area

    Directory of Open Access Journals (Sweden)

    O. Maršálek

    2015-12-01

    Full Text Available The main goal of this article is to experimentally evaluate the contact area and to compare the measured results with the different contact model theories. The experiment takes advantage of the electrical contact resistivity principle in a dry piston/cylinder liner test rig assembly. Analytical contact models are implemented into the computational simulation. The calculated contact area depends on the dynamics and precomputed database of contact pressure and contact area in the relation to the separation distance of surfaces. Multibody System (MBS is augmented by a user-written FORTRAN subroutine and used for the solution.

  11. Electrical contacts principles and applications

    CERN Document Server

    Slade, Paul G

    2013-01-01

    Covering the theory, application, and testing of contact materials, Electrical Contacts: Principles and Applications, Second Edition introduces a thorough discussion on making electric contact and contact interface conduction; presents a general outline of, and measurement techniques for, important corrosion mechanisms; considers the results of contact wear when plug-in connections are made and broken; investigates the effect of thin noble metal plating on electronic connections; and relates crucial considerations for making high- and low-power contact joints. It examines contact use in switch

  12. New aspects in allergic contact dermatitis

    DEFF Research Database (Denmark)

    Mørtz, Charlotte G; Andersen, Klaus Ejner

    2008-01-01

    contact dermatitis. The main culprits include fragrance chemicals, preservatives, and hair dyes. We are all more or less exposed to cosmetics and topical drugs on a daily basis. The labelling requirements given in the Cosmetics Directive is of great help in tracing the causative allergenic ingredients...

  13. Contact Graph Routing

    Science.gov (United States)

    Burleigh, Scott C.

    2011-01-01

    Contact Graph Routing (CGR) is a dynamic routing system that computes routes through a time-varying topology of scheduled communication contacts in a network based on the DTN (Delay-Tolerant Networking) architecture. It is designed to enable dynamic selection of data transmission routes in a space network based on DTN. This dynamic responsiveness in route computation should be significantly more effective and less expensive than static routing, increasing total data return while at the same time reducing mission operations cost and risk. The basic strategy of CGR is to take advantage of the fact that, since flight mission communication operations are planned in detail, the communication routes between any pair of bundle agents in a population of nodes that have all been informed of one another's plans can be inferred from those plans rather than discovered via dialogue (which is impractical over long one-way-light-time space links). Messages that convey this planning information are used to construct contact graphs (time-varying models of network connectivity) from which CGR automatically computes efficient routes for bundles. Automatic route selection increases the flexibility and resilience of the space network, simplifying cross-support and reducing mission management costs. Note that there are no routing tables in Contact Graph Routing. The best route for a bundle destined for a given node may routinely be different from the best route for a different bundle destined for the same node, depending on bundle priority, bundle expiration time, and changes in the current lengths of transmission queues for neighboring nodes; routes must be computed individually for each bundle, from the Bundle Protocol agent's current network connectivity model for the bundle s destination node (the contact graph). Clearly this places a premium on optimizing the implementation of the route computation algorithm. The scalability of CGR to very large networks remains a research topic

  14. HTSC-Josephson step contacts

    International Nuclear Information System (INIS)

    In this work the properties of josephson step contacts are investigated. After a short introduction into Josephson step contacts the structure, properties and the Josphson contacts of YBa2Cu3O7-x high-Tc superconductors is presented. The fabrication of HTSC step contacts and the microstructure is discussed. The electric properties of these contacts are measured together with the Josephson emission and the magnetic field dependence. The temperature dependence of the stationary transport properties is given. (WL)

  15. Contact dermatitis from propolis.

    Science.gov (United States)

    Wanscher, B

    1976-04-01

    Two patients with contact dermatitis due to the natural product propolis (bee glue) are reported. They presented perioral eczema and stomatitis which were recalcitrant until propolis was considered as the cause. Patch tests with propolis preparations were positive in both patients, and, furthermore, in the second patient the lesions relapsed after provocation tests. European standard patch test including balsam of Peru were negative. The complexity of propolis, its supposed anti-inflammatory effect due to flavonoids, and the sensitizing agents originating mainly from the poplar trees are discussed together with the cross-sensitization to balsam of Peru. Contact dermatitis due to propolis should be considered in unexplained eczemas, mainly perioral but also in other areas, as propolis preparations are available also as ointments and cosmetic creams. PMID:1268058

  16. "I don't need my patients' opinion to withdraw treatment": patient preferences at the end-of-life and physician attitudes towards advance directives in England and France.

    OpenAIRE

    Horn, R

    2014-01-01

    This paper presents the results of a qualitative interview study exploring English and French physicians' moral perspectives and attitudes towards end-of-life decisions when patients lack capacity to make decisions for themselves. The paper aims to examine the importance physicians from different contexts accord to patient preferences and to explore the (potential) role of advance directives (ADs) in each context. The interviews focus on (1) problems that emerge when deciding to withdraw/-hol...

  17. Contact stress sensor

    Science.gov (United States)

    Kotovsky, Jack

    2012-02-07

    A contact stress sensor includes one or more MEMS fabricated sensor elements, where each sensor element of includes a thin non-recessed portion, a recessed portion and a pressure sensitive element adjacent to the recessed portion. An electric circuit is connected to the pressure sensitive element. The circuit includes a thermal compensator and a pressure signal circuit element configured to provide a signal upon movement of the pressure sensitive element.

  18. Hydrogels contact lenses

    Czech Academy of Sciences Publication Activity Database

    Michálek, Jiří; Hobzová, Radka; Přádný, Martin; Dušková, Miroslava

    New York : Springer, 2010 - (Ottenbrite, R.; Park, K.; Okano, T.), s. 303-315 ISBN 978-1-4419-5918-8 R&D Projects: GA AV ČR KAN200520804 Institutional research plan: CEZ:AV0Z40500505 Keywords : contact lenses * hydrogels * silicone-hydrogels Subject RIV: EI - Biotechnology ; Bionics http://www.springerlink.com/content/l32kx3303v110unn/

  19. Occupational protein contact dermatitis.

    Science.gov (United States)

    Barbaud, Annick; Poreaux, Claire; Penven, Emmanuelle; Waton, Julie

    2015-12-01

    Occupational contact dermatitis is generally caused by haptens but can also be induced by proteins causing mainly immunological contact urticaria (ICU); chronic hand eczema in the context of protein contact dermatitis (PCD). In a monocentric retrospective study, from our database, only 31 (0.41%) of patients with contact dermatitis had positive skin tests with proteins: 22 had occupational PCD, 3 had non-occupational PCD, 5 occupational ICU and 1 cook had a neutrophilic fixed food eruption (NFFE) due to fish. From these results and analysis of literature, the characteristics of PCD can be summarized as follows. It is a chronic eczematous dermatitis, possibly exacerbated by work, suggestive if associated with inflammatory perionyxix and immediate erythema with pruritis, to be investigated when the patient resumes work after a period of interruption. Prick tests with the suspected protein-containing material are essential, as patch tests have negative results. In case of multisensitisation revealed by prick tests, it is advisable to analyse IgE against recombinant allergens. A history of atopy, found in 56 to 68% of the patients, has to be checked for. Most of the cases are observed among food-handlers but PCD can also be due to non-edible plants, latex, hydrolysed proteins or animal proteins. Occupational exposure to proteins can thus lead to the development of ICU. Reflecting hypersensitivity to very low concentrations of allergens, investigating ICU therefore requires caution and prick tests should be performed with a diluted form of the causative protein-containing product. Causes are food, especially fruit peel, non-edible plants, cosmetic products, latex, animals. PMID:26242922

  20. Pediatric contact dermatitis

    Directory of Open Access Journals (Sweden)

    Sharma Vinod

    2010-01-01

    Full Text Available Allergic contact dermatitis (ACD in children, until recently, was considered rare. ACD was considered as a disorder of the adult population and children were thought to be spared due to a lack of exposure to potential allergens and an immature immune system. Prevalence of ACD to even the most common allergens in children, like poison ivy and parthenium, is relatively rare as compared to adults. However, there is now growing evidence of contact sensitization of the pediatric population, and it begins right from early childhood, including 1-week-old neonates. Vaccinations, piercing, topical medicaments and cosmetics in younger patients are potential exposures for sensitization. Nickel is the most common sensitizer in almost all studies pertaining to pediatric contact dermatitis. Other common allergens reported are cobalt, fragrance mix, rubber, lanolin, thiomersol, neomycin, gold, mercapto mix, balsum of Peru and colophony. Different factors like age, sex, atopy, social and cultural practices, habit of parents and caregivers and geographic changes affect the patterns of ACD and their variable clinical presentation. Patch testing should be considered not only in children with lesions of a morphology suggestive of ACD, but in any child with dermatitis that is difficult to control.

  1. Pediatric contact dermatitis.

    Science.gov (United States)

    Sharma, Vinod K; Asati, Dinesh P

    2010-01-01

    Allergic contact dermatitis (ACD) in children, until recently, was considered rare. ACD was considered as a disorder of the adult population and children were thought to be spared due to a lack of exposure to potential allergens and an immature immune system. Prevalence of ACD to even the most common allergens in children, like poison ivy and parthenium, is relatively rare as compared to adults. However, there is now growing evidence of contact sensitization of the pediatric population, and it begins right from early childhood, including 1-week-old neonates. Vaccinations, piercing, topical medicaments and cosmetics in younger patients are potential exposures for sensitization. Nickel is the most common sensitizer in almost all studies pertaining to pediatric contact dermatitis. Other common allergens reported are cobalt, fragrance mix, rubber, lanolin, thiomersol, neomycin, gold, mercapto mix, balsum of Peru and colophony. Different factors like age, sex, atopy, social and cultural practices, habit of parents and caregivers and geographic changes affect the patterns of ACD and their variable clinical presentation. Patch testing should be considered not only in children with lesions of a morphology suggestive of ACD, but in any child with dermatitis that is difficult to control. PMID:20826990

  2. Functional modular contact lens

    Science.gov (United States)

    Shum, Angela J.; Cowan, Melissa; Lähdesmäki, Ilkka; Lingley, Andrew; Otis, Brian; Parviz, Babak A.

    2009-08-01

    Tear fluid offers a potential route for non-invasive sensing of physiological parameters. Utilization of this potential depends on the ability to manufacture sensors that can be placed on the surface of the eye. A contact lens makes a natural platform for such sensors, but contact lens polymers present a challenge for sensor fabrication. This paper describes a microfabrication process for constructing sensors that can be integrated into the structure of a functional contact lens in the future. To demonstrate the capabilities of the process, an amperometric glucose sensor was fabricated on a polymer substrate. The sensor consists of platinum working and counter electrodes, as well as a region of indium-tin oxide (ITO) for glucose oxidase immobilization. An external silver-silver chloride electrode was used as the reference electrode during the characterization experiments. Sensor operation was validated by hydrogen peroxide measurements in the 10- 20 μM range and glucose measurements in the 0.125-20 mM range.

  3. Optimizing contact force during ablation of atrial fibrillation: available technologies and a look to the future.

    Science.gov (United States)

    de Vries, Lennart J; Szili-Torok, Tamas

    2016-03-01

    In a select atrial fibrillation population, catheter ablation is considered first-line therapy. Prevention of early reconnection of the isolated pulmonary veins is an important goal for a successful treatment. Here, adequate catheter-tissue contact is crucial. One of the most promising new advances, therefore, is contact force (CF) sensing technology. The aim of this review is to provide an overview of innovations regarding catheter ablation of atrial fibrillation with a special focus on CF optimization. Both experimental and human studies show how CF sensing catheters lead to a reduction of fluoroscopy time, increased procedural safety and a better clinical outcome. Possible future developments include new parameters combining real-time ablation data, direct visualization of lesion formation and incorporation of robotics. PMID:26916025

  4. Dual contact pogo pin assembly

    Energy Technology Data Exchange (ETDEWEB)

    Hatch, Stephen McGarry

    2016-06-21

    A contact assembly includes a base and a pair of electrical contacts supported by the base. A first end of the first electrical contact corresponds to a first end of the base and is configured to engage a first external conductive circuit element. A first end of the second electrical contact also corresponds to the first end of the base and is configured to engage a second external conductive circuit element. The first contact and the second contact are electrically isolated from one another and configured to compress when engaging an external connector element. The base includes an aperture positioned on a second end of the base outboard of a second end of the first and second electrical contacts. The aperture presents a narrowing shape with a wide mouth distal the electrical contacts and a narrow internal through-hole proximate the electrical contacts.

  5. FY2001 Final Report Laboratory Directed Research and Development (LDRD) on Advanced Nuclear Fuel Design in the Future Nuclear Energy Market

    Energy Technology Data Exchange (ETDEWEB)

    Christensen, D.; Choi, J.-S.; DiSabatino, A.; Wirth, B.

    2001-09-30

    This study is to research the maturity of advanced nuclear fuel and cladding technology and to explore the suitability of existing technology for addressing the emerging requirements for Generation IV reactors and emerging thermal/fast spectrum reactors, while simultaneously addressing nuclear waste management, and proliferation resistance concerns.

  6. Tight Planar Contact Manifolds with Vanishing Heegaard Floer Contact Invariants

    OpenAIRE

    Conway, James; Kaloti, Amey; Kulkarni, Dheeraj

    2014-01-01

    In this note, we exhibit infinite families of tight non-fillable contact manifolds supported by planar open books with vanishing Heegaard Floer contact invariants. Moreover, we also exhibit an infinite such family where the supported manifold is hyperbolic.

  7. Measuring the specific contact resistance of contacts to semiconductor nanowires

    Science.gov (United States)

    Mohney, S. E.; Wang, Y.; Cabassi, M. A.; Lew, K. K.; Dey, S.; Redwing, J. M.; Mayer, T. S.

    2005-02-01

    Ohmic contacts to semiconductor nanowires are essential components of many new nanoscale electronic devices. Equations for extracting specific contact resistance (or contact resistivity) from several different test structures have been developed by modeling the metal/semiconductor contact as a transmission line, leading to the development of equations analogous to those used for planar contacts. The advantages and disadvantages of various test structures are discussed. To fabricate test structures using a convenient four-point approach, silicon nanowires have been aligned using field-assisted assembly and contacts fabricated. Finally, specific contact resistances near 5 × 10 -4 Ω cm 2 have been measured for Ti/Au contacts to p-type Si nanowires with diameters of 78 and 104 nm.

  8. 医学院校本科生对医疗预立的认知状况分析%Study on the Cognition of Undergraduates on Advance Directives in Medical Undergraduates

    Institute of Scientific and Technical Information of China (English)

    管秉书; 刘婵娟; 崔仕臣; 孟雪晖

    2015-01-01

    目的:了解某医学高校本科生对医疗预立的认知现状,分析医疗预立认知的影响因素。方法采用分层整群随机抽样的方法,采用自行设计的调查问卷对某医学高校的594名本科生进行问卷调查。结果调查对象对医疗预立的认知情况总体较差。在认知影响因素的分析中,性别、健康状况自评、平均月生活费、生存时间和生存质量的情景选择、家庭医疗保险的种类等变量差异有统计学意义(P<0.05)。结论医学高校本科生对医疗预立的认知情况总体较差,应采取相关措施来提高大学生对医疗预立的认知。%Objective:To explore the cognition of undergraduates on advance directives in a medical universi -ty, and to analyze the affect factors on cognition status of advance directives .Method: Total 594 undergraduates were selected by stratified cluster random sampling and this study conducted a face to face interview using self -de-signed questionnaire .Results: The cognitive status on advance directives was poor .This study found the inde-pendent variables of the gender , religion, the self-reported health, the average monthly living expenditure , the survival time and quality choice and the type of health insurance were the effect factors (P<0.05).Conclusion:the undergraduates′cognitive status on advance directives was poor in this medical university , and we need adopt relevant measures to improve the cognitive of undergraduates on advance directives .

  9. Multicrystalline and Back Contact Buried Contact Silicon Solar Cells

    OpenAIRE

    Jooß, Wolfgang

    2002-01-01

    This thesis examines multicrystalline silicon (mc-Si) as well as back contact silicon solar cells applying the Buried Contact Solar Cell (BCSC) technology. In this metallisation approach, the electrical contacts are buried into the silicon wafer leading to low shadowing losses in conjunction with highly conducting contact fingers. Further features include a selective emitter structure as well as surface passivation. A baseline process for the manufacturing of BCSC was developed which includes...

  10. Thermal conductance of carbon nanotube contacts: Molecular dynamics simulations and general description of the contact conductance

    Science.gov (United States)

    Salaway, Richard N.; Zhigilei, Leonid V.

    2016-07-01

    The contact conductance of carbon nanotube (CNT) junctions is the key factor that controls the collective heat transfer through CNT networks or CNT-based materials. An improved understanding of the dependence of the intertube conductance on the contact structure and local environment is needed for predictive computational modeling or theoretical description of the effective thermal conductivity of CNT materials. To investigate the effect of local structure on the thermal conductance across CNT-CNT contact regions, nonequilibrium molecular dynamics (MD) simulations are performed for different intertube contact configurations (parallel fully or partially overlapping CNTs and CNTs crossing each other at different angles) and local structural environments characteristic of CNT network materials. The results of MD simulations predict a stronger CNT length dependence present over a broader range of lengths than has been previously reported and suggest that the effect of neighboring junctions on the conductance of CNT-CNT junctions is weak and only present when the CNTs that make up the junctions are within the range of direct van der Waals interaction with each other. A detailed analysis of the results obtained for a diverse range of intertube contact configurations reveals a nonlinear dependence of the conductance on the contact area (or number of interatomic intertube interactions) and suggests larger contributions to the conductance from areas of the contact where the density of interatomic intertube interactions is smaller. An empirical relation accounting for these observations and expressing the conductance of an arbitrary contact configuration through the total number of interatomic intertube interactions and the average number of interatomic intertube interactions per atom in the contact region is proposed. The empirical relation is found to provide a good quantitative description of the contact conductance for various CNT configurations investigated in the MD

  11. Liquid contact resonance AFM: analytical models, experiments, and limitations

    Science.gov (United States)

    Parlak, Zehra; Tu, Qing; Zauscher, Stefan

    2014-11-01

    Contact resonance AFM (CR-AFM) is a scanning probe microscopy technique that utilizes the contact resonances of the AFM cantilever for concurrent imaging of topography and surface stiffness. The technique has not been used in liquid until recently due to analytical and experimental difficulties, associated with viscous damping of cantilever vibrations and fluid loading effects. To address these difficulties, (i) an analytical approach for contact resonances in liquid is developed, and (ii) direct excitation of the contact resonances is demonstrated by actuating the cantilever directly in a magnetic field. By implementing the analytical approach and the direct actuation through magnetic particles, quantitative stiffness imaging on surfaces with a wide range of stiffness can be achieved in liquid with soft cantilevers and low contact forces.

  12. Liquid contact resonance AFM: analytical models, experiments, and limitations

    International Nuclear Information System (INIS)

    Contact resonance AFM (CR-AFM) is a scanning probe microscopy technique that utilizes the contact resonances of the AFM cantilever for concurrent imaging of topography and surface stiffness. The technique has not been used in liquid until recently due to analytical and experimental difficulties, associated with viscous damping of cantilever vibrations and fluid loading effects. To address these difficulties, (i) an analytical approach for contact resonances in liquid is developed, and (ii) direct excitation of the contact resonances is demonstrated by actuating the cantilever directly in a magnetic field. By implementing the analytical approach and the direct actuation through magnetic particles, quantitative stiffness imaging on surfaces with a wide range of stiffness can be achieved in liquid with soft cantilevers and low contact forces. (paper)

  13. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... damages the optic nerve. When Cancer Treatment Caused Cataracts, Surgery Helped Her See Again MAY 06, 2016 By Cheryl terHorst Judy Borger has faced many treatment-related challenges since being diagnosed with acute lymphocytic leukemia nearly eight years ago. Among them was the development of ... Ophthalmologist Advanced Search ...

  14. Contact resistivities of metal-insulator-semiconductor contacts and metal-semiconductor contacts

    Science.gov (United States)

    Yu, Hao; Schaekers, Marc; Barla, Kathy; Horiguchi, Naoto; Collaert, Nadine; Thean, Aaron Voon-Yew; De Meyer, Kristin

    2016-04-01

    Applying simulations and experiments, this paper systematically compares contact resistivities (ρc) of metal-insulator-semiconductor (MIS) contacts and metal-semiconductor (MS) contacts with various semiconductor doping concentrations (Nd). Compared with the MS contacts, the MIS contacts with the low Schottky barrier height are more beneficial for ρc on semiconductors with low Nd, but this benefit diminishes gradually when Nd increases. With high Nd, we find that even an "ideal" MIS contact with optimized parameters cannot outperform the MS contact. As a result, the MIS contacts mainly apply to devices that use relatively low doped semiconductors, while we need to focus on the MS contacts to meet the sub-1 × 10-8 Ω cm2 ρc requirement for future Complementary Metal-Oxide-Semiconductor (CMOS) technology.

  15. Cosmetic Contact Allergens

    OpenAIRE

    An Goossens

    2016-01-01

    This article presents trends in the frequency of cosmetics as causal factors of allergic contact dermatitis during a 26-year period in 14,911 patients patch-tested between 1990 and 2014, and discusses the cosmetic allergens identified during the last six years (2010–2015) in 603 patients out of 3105 tested. The data were retrieved from, and evaluated with, a patient database developed in-house. The results show the increasing importance of cosmetic allergies, up to 25% of the patients tested ...

  16. Contact dermatitis to sandalwood

    Directory of Open Access Journals (Sweden)

    Gupta Ramji

    1994-01-01

    Full Text Available A 80-year-old priest developed itchy, erythematous, scaly and fissured area on the centre of his forehead, palmar aspect of right hand fingers and medial half of left palm. These were suspected to be contact dermatitis due to sandalwood paste he was using on these areas. Patch test with sandalwood paste was positive. All the lesions cleared in 10 days after stopping application of sandalwood paste and topical application of betamethasone valerate cream and recurred in 2 days when the application of paste was restarted.

  17. Contact dermatitis in Nigeria.

    Science.gov (United States)

    Olumide, Y M

    1985-05-01

    Nickel is the most important sensitizer in Lagos, with an incidence of 12.3% of 453 patients tested. There was no sex difference, as the wearing of necklaces and bracelets was equally fashionable among both sexes. Housewife eczema is not common, probably because of hardening. Dermatitis from additives in the processing of leather and rubber footwear was the next most common. Chromate sensitivity comes usually from leather or cement. Cultural and climatic factors are mainly responsible for differences in the incidence of contact dermatitis found in Lagos from other countries. PMID:4028699

  18. Advance directives in action in a regional palliative care service: "road testing" the provisions of the Medical Treatment Act 1988 (VIC).

    Science.gov (United States)

    Brown, Margaret; Fisher, John W; Brumley, David J; Ashby, Michael A; Milliken, Jan

    2005-11-01

    In order to explore the usefulness and acceptability of the provisions of the Medical Treatment Act 1988 (Vic) for palliative care patients in a rural region in Victoria, Australia, between July and December 2004 patients were given information explaining the Act and the opportunity to discuss it with the research officer. Grounded theory methodology was used to evaluate client responses. Findings suggested that palliative care patients are willing to engage in advance care planning but they have to be well enough and need skilled, practical, face-to-face assistance to complete the required legal forms. Written materials alone are not adequate, but provide the opportunity for medical staff to have conversations about death and dying. Doctors and nurses should understand the provisions of the Act to assist patients and families. It is recommended that advance care planning, appropriate to the jurisdiction, be an integral part of the palliative care assessment process. PMID:16304759

  19. A Method for Biomarker Directed Survival Prediction in Advanced Non-Small-Cell Lung Cancer Patients Treated with Carboplatin-Based Therapy

    Directory of Open Access Journals (Sweden)

    Wei Chen

    2013-09-01

    Full Text Available Platinum-based chemotherapy is a primary treatment of choice for advanced non-small-cell lung cancer (NSCLC. Analytical methods to specifically evaluate biomarkers predictive of therapeutic efficacy have not been developed. Two randomized phase III trials of carboplatin-based chemotherapy in advanced NSCLC were used for learning and validating the predictive value of ERCC1 in situ protein levels, as measured by accurate quantitative analysis (AQUA. A novel Bayesian method was applied to identify the outcome-based threshold in the learning trial only. Overall survival (OS was assessed by Kaplan-Meier analysis with log rank testing to determine statistical significance in the validating trial. For patients treated with gemcitabine and carboplatin, the median OS was 9.5 months (95% CI 6.7 to 11.8 for the high ERCC1 group compared to 15.6 months (95% CI 11.6 to 24.8 for the low ERCC1 group in the validation trial (log rank p-value = 0.007. The hazard ratio for low ERCC1 was 0.598 (95% CI, 0.394 to 0.908; p = 0.016 relative to high ERCC1 adjusted for age, sex, and histology. Conclusions: Patients with advanced NSCLC could be stratified into high and low ERCC1 expression groups. Patients with low levels benefited from platinum-based chemotherapy, whereas those with high levels did not.

  20. Current management and future directions in the treatment of advanced renal cell carcinoma-a latin american perspective: 10 years in review.

    Science.gov (United States)

    Smaletz, Oren

    2015-01-01

    The worldwide incidence of kidney cancer is estimated at 337,860 new cases per year in the International Agency for Research on Cancer's GLOBOCAN 2012 update, with an estimated 143,369 deaths annually. Over the past 10 years, there have been significant advances in the treatment of advanced/metastatic renal cell carcinoma, including the development of targeted therapies. Currently recommended first-line treatments include sunitinib, temsirolimus, bevacizumab plus interferon, and pazopanib, or high-dose interleukin-2 or sorafenib for selected patients. Recommended second-line treatments include all of the above agents, as well as everolimus and axitinib. Unfortunately, combination therapies have generally resulted in increased toxicity and little improvement in efficacy. Recent studies focused on identification of predictive biomarkers for responses to specific targeted therapies and have not been successful to date. Despite recent advances in targeted treatment for metastatic renal cell carcinoma, important questions regarding biomarkers of efficacy, and optimal combination and sequencing of agents remain to be answered. This paper reviews literature concerned with first-and second-line treatment of metastatic renal cell carcinoma and will discuss key issues in Latin America. PMID:26689508

  1. Current management and future directions in the treatment of advanced renal cell carcinoma-a latin american perspective: 10 years in review

    Directory of Open Access Journals (Sweden)

    Oren Smaletz

    2015-10-01

    Full Text Available ABSTRACT The worldwide incidence of kidney cancer is estimated at 337,860 new cases per year in the International Agency for Research on Cancer's GLOBOCAN 2012 update, with an estimated 143,369 deaths annually. Over the past 10 years, there have been significant advances in the treatment of advanced/metastatic renal cell carcinoma, including the development of targeted therapies. Currently recommended first-line treatments include sunitinib, temsirolimus, bevacizumab plus interferon, and pazopanib, or high-dose interleukin-2 or sorafenib for selected patients. Recommended second-line treatments include all of the above agents, as well as everolimus and axitinib. Unfortunately, combination therapies have generally resulted in increased toxicity and little improvement in efficacy. Recent studies focused on identification of predictive biomarkers for responses to specific targeted therapies and have not been successful to date. Despite recent advances in targeted treatment for metastatic renal cell carcinoma, important questions regarding biomarkers of efficacy, and optimal combination and sequencing of agents remain to be answered. This paper reviews literature concerned with first-and second-line treatment of metastatic renal cell carcinoma and will discuss key issues in Latin America.

  2. Optimal contact definition for reconstruction of Contact Maps

    Directory of Open Access Journals (Sweden)

    Stehr Henning

    2010-05-01

    Full Text Available Abstract Background Contact maps have been extensively used as a simplified representation of protein structures. They capture most important features of a protein's fold, being preferred by a number of researchers for the description and study of protein structures. Inspired by the model's simplicity many groups have dedicated a considerable amount of effort towards contact prediction as a proxy for protein structure prediction. However a contact map's biological interest is subject to the availability of reliable methods for the 3-dimensional reconstruction of the structure. Results We use an implementation of the well-known distance geometry protocol to build realistic protein 3-dimensional models from contact maps, performing an extensive exploration of many of the parameters involved in the reconstruction process. We try to address the questions: a to what accuracy does a contact map represent its corresponding 3D structure, b what is the best contact map representation with regard to reconstructability and c what is the effect of partial or inaccurate contact information on the 3D structure recovery. Our results suggest that contact maps derived from the application of a distance cutoff of 9 to 11Å around the Cβ atoms constitute the most accurate representation of the 3D structure. The reconstruction process does not provide a single solution to the problem but rather an ensemble of conformations that are within 2Å RMSD of the crystal structure and with lower values for the pairwise average ensemble RMSD. Interestingly it is still possible to recover a structure with partial contact information, although wrong contacts can lead to dramatic loss in reconstruction fidelity. Conclusions Thus contact maps represent a valid approximation to the structures with an accuracy comparable to that of experimental methods. The optimal contact definitions constitute key guidelines for methods based on contact maps such as structure prediction through

  3. Allergic contact dermatitis from octylisothiazolinone

    DEFF Research Database (Denmark)

    Mose, Anja Pahlow; Frost, Simon; Ohlund, Ulf;

    2013-01-01

    Octylisothiazolinone is a biocide that has been reported as a moderate, but rare contact allergen.......Octylisothiazolinone is a biocide that has been reported as a moderate, but rare contact allergen....

  4. Contact Center Manager Administration (CCMA)

    Data.gov (United States)

    Social Security Administration — CCMA is the server that provides a browser-based tool for contact center administrators and supervisors. It is used to manage and configure contact center resources...

  5. Contact Lenses in the Laboratory.

    Science.gov (United States)

    Kingston, David W.

    1981-01-01

    Summarizes results of a three-item questionnaire returned by 43 Michigan institutions expressing views on wearing contact lenses in chemical laboratories. Questions focused on eye protection, type of protection, and use of contact lenses. (SK)

  6. Advanced energy projects: FY 1987 research summaries

    International Nuclear Information System (INIS)

    This report contains brief summaries of all projects active in the Division of Advanced Energy Projects during Fiscal Year 1987 (October 1, 1986-September 30, 1987). The intent of this compilation is to provide a convenient means for quickly acquainting an interested reader with the program in Advanced Energy Projects. More detailed information on research activities in a particular project may be obtained by contacting directly the principal investigator. Some projects will have reached the end of their contract periods by the time this book appears, and will, therefore, no longer be active. Those cases in which work was completed in FY '87 are indicated by the footnote: Project completed. The annual funding level of each project is shown

  7. 21 CFR 886.5916 - Rigid gas permeable contact lens.

    Science.gov (United States)

    2010-04-01

    ... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Rigid gas permeable contact lens. 886.5916 Section... lens. (a) Identification. A rigid gas permeable contact lens is a device intended to be worn directly against the cornea of the eye to correct vision conditions. The device is made of various materials,...

  8. Contextualizing Intergroup Contact: Do Political Party Cues Enhance Contact Effects?

    DEFF Research Database (Denmark)

    Sønderskov, Kim Mannemar; Thomsen, Jens Peter Frølund

    2015-01-01

    political parties on us-them categorizations heightens the awareness of group memberships. This focus in turn enhances the positive intergroup contact effect by stimulating majority members to perceive contacted persons as prototypical outgroup members. A multilevel analysis of 22 countries and almost 37......,000 individuals confirms that the ability of intergroup contact to reduce antiforeigner sentiment increases when political parties focus intensively on immigration issues and cultural differences. Specifically, both workplace contact and interethnic friendship become more effective in reducing antiforeigner...... sentiment when intergroup relations are politicized. These findings demonstrate the need for widening the scope of the intergroup contact theory in order to cover macro-political conditions....

  9. Contact and non-contact ultrasonic measurement in the food industry: a review

    International Nuclear Information System (INIS)

    The monitoring of the food manufacturing process is vital since it determines the safety and quality level of foods which directly affect the consumers’ health. Companies which produce high quality products will gain trust from consumers. This factor helps the companies to make profits. The use of efficient and appropriate sensors for the monitoring process can also reduce cost. The food assessing process based on an ultrasonic sensor has attracted the attention of the food industry due to its excellent capabilities in several applications. The utilization of low or high frequencies for the ultrasonic transducer has provided an enormous benefit for analysing, modifying and guaranteeing the quality of food. The contact and non-contact ultrasonic modes for measurement also contributed significantly to the food processing. This paper presents a review of the application of the contact and non-contact mode of ultrasonic measurement focusing on safety and quality control areas. The results from previous researches are shown and elaborated. (topical review)

  10. Contact and non-contact ultrasonic measurement in the food industry: a review

    Science.gov (United States)

    Taufiq Mohd Khairi, Mohd; Ibrahim, Sallehuddin; Yunus, Mohd Amri Md; Faramarzi, Mahdi

    2016-01-01

    The monitoring of the food manufacturing process is vital since it determines the safety and quality level of foods which directly affect the consumers’ health. Companies which produce high quality products will gain trust from consumers. This factor helps the companies to make profits. The use of efficient and appropriate sensors for the monitoring process can also reduce cost. The food assessing process based on an ultrasonic sensor has attracted the attention of the food industry due to its excellent capabilities in several applications. The utilization of low or high frequencies for the ultrasonic transducer has provided an enormous benefit for analysing, modifying and guaranteeing the quality of food. The contact and non-contact ultrasonic modes for measurement also contributed significantly to the food processing. This paper presents a review of the application of the contact and non-contact mode of ultrasonic measurement focusing on safety and quality control areas. The results from previous researches are shown and elaborated.

  11. Quantum Contact Transmission

    Institute of Scientific and Technical Information of China (English)

    崔迪

    2015-01-01

    Abstract:Quantum transmission is based on quantum entanglement, which is a kind of the phenomenon of quantum mechanics. Quantum object refers to two or more between the localized, the classic strong correlation. When two object quantum entanglement in the quantum state is not independent, but related, and the correlation distance, a pair of electronic of entanglement state, no matter how far apart, they spin direction will remain an up and a down. If one of the electronic spin direction is changed, another of the electron spin direction wil follow to change immediately.

  12. Mass spectrometry-based proteomic analyses of contact lens deposition

    OpenAIRE

    Green-Church, Kari B.; Nichols, Jason J.

    2008-01-01

    Purpose The purpose of this report is to describe the contact lens deposition proteome associated with two silicone hydrogel contact lenses and care solutions using a mass spectrometric-based approach. Methods This was a randomized, controlled, examiner-masked crossover clinical trial that included 48 participants. Lenses and no-rub care solutions evaluated included galyfilcon A (Acuvue Advance, Vistakon Inc., Jacksonville, FL), lotrafilcon B (O2 Optix, CIBA Vision Inc., Duluth, GA), AQuify (...

  13. Phosphoinositides in membrane contact sites.

    Science.gov (United States)

    Raiborg, Camilla; Wenzel, Eva M; Pedersen, Nina M; Stenmark, Harald

    2016-04-15

    Cellular membranes communicate extensively via contact sites that form between two membranes. Such sites allow exchange of specific ions, lipids or proteins between two compartments without content mixing, thereby preserving organellar architecture during the transfer process. Even though the molecular compositions of membrane contact sites are diverse, it is striking that several of these sites, including contact sites between the endoplasmic reticulum (ER) and endosomes, Golgi and the plasma membrane (PM), and contact sites between lysosomes and peroxisomes, contain phosphorylated derivatives of phosphatidylinositol known as phosphoinositides. In this mini-review we discuss the involvement and functions of phosphoinositides in membrane contact sites. PMID:27068950

  14. Cosmetic Contact Allergens

    Directory of Open Access Journals (Sweden)

    An Goossens

    2016-02-01

    Full Text Available This article presents trends in the frequency of cosmetics as causal factors of allergic contact dermatitis during a 26-year period in 14,911 patients patch-tested between 1990 and 2014, and discusses the cosmetic allergens identified during the last six years (2010–2015 in 603 patients out of 3105 tested. The data were retrieved from, and evaluated with, a patient database developed in-house. The results show the increasing importance of cosmetic allergies, up to 25% of the patients tested during the last five-year period. As expected, fragrance materials, preservatives, and hair dyes were the most frequent culprits, but a great variety of other allergenic ingredients were involved as well. This underlines the need of additional and extensive patch testing with the patient’s products used and their ingredients.

  15. Contact dermatitis to Alstroemeria.

    Science.gov (United States)

    Santucci, B; Picardo, M; Iavarone, C; Trogolo, C

    1985-04-01

    A study was carried out on 50 workers in a floriculture centre to evaluate the incidence of contact dermatitis to Alstroemeria. 3 subjects gave positive reactions to aqueous and ethanolic extracts of cut flowers, stems and leaves. By column chromatography, the allergen was isolated and its chemical structure identified as 6-tuliposide A by proton magnetic resonance and carbon-13 magnetic resonance. Only 6-tuliposide A was isolated from cut flowers, and this gave positive reactions when patch tested at 0.01%; a-methylene-gamma-butyrolactone at 10(-5) (v/v) was positive in the same 3 subjects. Other lactones (gamma-methylene-gamma-butyrolactone, alantolactone, isoalantolactone) were negative at all concentrations used. PMID:3160533

  16. Phonon relaxation of subgap levels in superconducting quantum point contacts

    International Nuclear Information System (INIS)

    Superconducting quantum point contacts (SQPC) are known to possess two subgap states per each propagating mode. The phonon relaxation in SQPC is considered for the case, when the superconducting phases on the contact terminal ase assumed to be rigidly fixed. The direct relaxation rate of subgap states in SQPC with the emission of an acoustic phonon is calculated at low temperature T. If the reflection in the contact is small, the relaxation time may become much longer than the characteristic lifetime of a bulk quasiparticle. The relaxation rate does not vanish T → 0, but it is strongly suppressed in the case of a nearly ballistic contact

  17. Langerhans cells in allergic contact dermatitis.

    Science.gov (United States)

    Tuchinda, P; Gaspari, A A

    2010-12-01

    Allergic contact dermatitis (ACD) is a common skin disease that has significant socio-economic impact. ACD is mediated by a T-cell mediated inflammatory reaction. Langerhans cells (LCs) are an epidermal DCs subset specialized in antigen presentation. After hapten exposure, LCs play a major role as in induction adaptive immune response against allergens. LCs recognize, take up and process haptens and migrate to the local draining lymph nodes. However, LCs specific functions and the LCs migration to local draining lymph nodes are not yet clearly defined. Recent advance in the knowledge of LCs function has increased in the past decades including the evidence for a tolerogenic function of LCs. The present review will focus on the role for LCs response to contact allergens. PMID:21139551

  18. Contact and Non-contact Measurements of Grinding Pins

    Directory of Open Access Journals (Sweden)

    Magdziak Marek

    2015-01-01

    Full Text Available The paper presents the results of contact and non-contact measurements of external profiles of selected grinding pins. The measurements were conducted in order to choose the appropriate measuring technique in the case of the considered measurement task. In the case of contact measurements the coordinate measuring machine ACCURA II was applied. The used coordinate measuring machine was equipped with the contact scanning probe VAST XT and the Calypso inspection software. Contact coordinate measurements were performed by using of different measurement strategies. The applied strategies included different scanning velocities and distances between measured points. Non-contact measurements were conducted by means of the tool presetter produced by the Mahr company. On the basis of gained results the guidelines concerning measurements of grinding pins were formulated. The measurements of analyzed grinding pins performed by means of the non-contact measuring system are characterized by higher reproducibility than the contact measurements. The low reproducibility of contact measurements may be connected with the inaccuracy of the selected coordinate measuring machine and the measuring probe, the measurement parameters and environmental conditions in the laboratory where the coordinate measuring machine is located. Moreover, the paper presents the possible application of results of conducted investigations. The results of non-contact measurements can be used in the simulation studies of grinding processes. The simulations may reduce the costs of machining processes.

  19. On-demand supply of slurry fuels to a porous anode of a direct carbon fuel cell: Attempts to increase fuel-anode contact and realize long-term operation

    Science.gov (United States)

    Li, Chengguo; Yi, Hakgyu; Lee, Donggeun

    2016-03-01

    In this paper, we propose a novel idea that might allow resolution of the two biggest challenges that hinder practical use of direct carbon fuel cells (DCFC). This work involved 1) the use of three types of porous Ni anode with different pore sizes, 2) size matching between the anode pores and solid fuel particles in a molten-carbonate (MC) slurry, and 3) provision of a continuous supply of fuel-MC slurry through the porous Ni anode. As a result, larger numbers of smaller pores in the anode were preferred for extending the triple phase boundary (TPB), as long as the fuel particles were sufficiently small to have full access to the inner pore spaces of the anode. For example, the maximal power density achieved in the case of optimal size matching, reached 645 mW cm-2, which is 14-times greater than that for the case of poorest size-matching and 64-times larger than that for a non-porous anode, and lasted for more than 20 h. After 20 h of steady operation at a fixed current density (700 mA cm-2), the electric potential slightly decreased due to partial consumption of the fuel. The cell performance readily recovered after restarting the supply of MC-fuel slurry.

  20. Point contacts in encapsulated graphene

    International Nuclear Information System (INIS)

    We present a method to establish inner point contacts with dimensions as small as 100 nm on hexagonal boron nitride (hBN) encapsulated graphene heterostructures by pre-patterning the top-hBN in a separate step prior to dry-stacking. 2- and 4-terminal field effect measurements between different lead combinations are in qualitative agreement with an electrostatic model assuming point-like contacts. The measured contact resistances are 0.5–1.5 kΩ per contact, which is quite low for such small contacts. By applying a perpendicular magnetic field, an insulating behaviour in the quantum Hall regime was observed, as expected for inner contacts. The fabricated contacts are compatible with high mobility graphene structures and open up the field for the realization of several electron optical proposals

  1. The contact network of patients in a regional healthcare system

    CERN Document Server

    Liljeros, Fredrik; Giesecke, Johan

    2007-01-01

    Yet in spite of advances in hospital treatment, hospitals continue to be a breeding ground for several airborne diseases and for diseases that are transmitted through close contacts like SARS, methicillin-resistant Staphylococcus aureus (MRSA), norovirus infections and tuberculosis (TB). Here we extract contact networks for up to 295,108 inpatients for durations up to two years from a database used for administrating a local public healthcare system serving a population of 1.9 million individuals. Structural and dynamical properties of the network of importance for the transmission of contagious diseases are then analyzed by methods from network epidemiology. The contact networks are found to be very much determined by an extreme (age independent) variation in duration of hospital stays and the hospital structure. We find that that the structure of contacts between in-patients exhibit structural properties, such as a high level of transitivity, assortativity and variation in number of contacts, that are likel...

  2. A CONTACT SEARCHING ALGORITHM FOR CONTACT-IMPACT PROBLEMS

    Institute of Scientific and Technical Information of China (English)

    Wang Fujun; Cheng Jiangang; Yao Zhenhan

    2000-01-01

    A new contact searching algorithm for contact-impact systems is proposed in this paper. In terms of the cell structure and the linked-list, this algorithm solves the problem of sorting and searching contacts in three dimensions by transforming it to a retrieving process from two one-dimensional arrays, and binary searching is no longer required. Using this algorithm, the cost of contact searching is reduced to the order of O(N) instead of O(Nlog2N) for traditional ones, where N is the node number in the system. Moreover, this algorithm can handle contact systems with arbitrary mesh layouts. Due to the simplicity of this algorithm it can be easily implemented in a dynamic explicit finite element Program. Our numerical experimental result shows that this algorithm is reliable and efficient for contact searching of three dimensional systems.

  3. Colored Contact Lens Dangers

    Medline Plus

    Full Text Available ... selling them in the United States. More Eye Health News Healthy Vision Month: How to Stay in Shape to Protect Your Eyes MAY 05, 2016 By Dan Gudgel Diet and lifestyle choices can directly affect your eyes. The best way to take care of your eyes during May’s Healthy Vision Month ...

  4. Contact sport and osteoarthritis.

    LENUS (Irish Health Repository)

    Molloy, Michael G

    2011-04-01

    Osteoarthritis (OA) is the most common joint disease in the world and the single largest cause of disability for those over 18 years. It affects more than twice as many people as does cardiac disease, and increases in incidence and prevalence with age. Animal and human studies have shown no evidence of increased risk of hip or knee OA with moderate exercise and in the absence of traumatic injury, sporting activity has a protective effect. One age-matched case control study found recreational runners who ran 12-14 miles per week for up to 40 years had no increase in radiological or symptomatic hip or knee OA. However, higher rates of hip OA occur in contact sports than in age-matched controls, with the highest rate in professional players. Soccer players with torn anterior cruciate ligaments (ACL) are more likely to develop knee OA than those with intact ACL. Early ACL repair reduces the risk of knee OA, but does not prevent it. Established injury prevention programmes have been refined to prevent injuries such as ACL rupture.

  5. Methylisothiazolinone contact allergy - A review

    DEFF Research Database (Denmark)

    Lundov, M D; Krongaard, Teddy; L Menné, T; Johansen, J D

    2011-01-01

    frequent causes of preservative contact allergy and early studies showed that both MI and MCI are sensitizers. The prevalence of MI contact allergy is already around 1·5% and sources of exposure are associated with occupation, cosmetic products or household products. Use of MI in industrial products is not...... restricted and cases of occupational contact allergy to MI e.g. in painters are reported. The frequency of use of MI in cosmetics is low, around 1%, while up to 16·5% of household products were preserved with MI. We found 19 (1·5%) out of 1272 cosmetic products labelled with MI, primarily rinse-off products...... contact allergy could be the first sign of an epidemic of MI contact allergy. The development in prevalence of MI contact allergy should be closely monitored by including MI in the European Baseline Series at 2000ppm....

  6. Methylisothiazolinone contact allergy: a review

    DEFF Research Database (Denmark)

    Lundov, M D; Krongaard, T; Menné, T L; Johansen, J D

    2011-01-01

    frequent causes of preservative contact allergy and early studies showed that both MI and MCI are sensitizers. The prevalence of MI contact allergy is already around 1·5% and sources of exposure are associated with occupation, cosmetic products or household products. Use of MI in industrial products is not...... restricted and cases of occupational contact allergy to MI e.g. in painters are reported. The frequency of use of MI in cosmetics is low, around 1%, while up to 16·5% of household products were preserved with MI. We found 19 (1·5%) out of 1272 cosmetic products labelled with MI, primarily rinse-off products...... contact allergy could be the first sign of an epidemic of MI contact allergy. The development in prevalence of MI contact allergy should be closely monitored by including MI in the European Baseline Series at 2000ppm....

  7. Advanced DVI+

    Energy Technology Data Exchange (ETDEWEB)

    Kwon, Tae Soon; Lee, S. T.; Euh, D. J.; Chu, I. C.; Youn, Y. J. [Korea Atomic Energy Research Institute, Daejeon (Korea, Republic of)

    2012-10-15

    A new advanced safety feature of DVI+ (Direct Vessel Injection Plus) for the APR+ (Advanced Power Reactor Plus), to mitigate the ECC (Emergency Core Cooling) bypass fraction and to prevent switching an ECC outlet to a break flow inlet during a DVI line break, is presented for an advanced DVI system. In the current DVI system, the ECC water injected into the downcomer is easily shifted to the broken cold leg by a high steam cross flow which comes from the intact cold legs during the late reflood phase of a LBLOCA (Large Break Loss Of Coolant Accident). For the new DVI+ system, an ECBD (Emergency Core Barrel Duct) is installed on the outside of a core barrel cylinder. The ECBD has a gap (From the core barrel wall to the ECBD inner wall to the radial direction) of 3/25-7/25 of the downcomer annulus gap. The DVI nozzle and the ECBD are only connected by the ECC water jet, which is called a hydrodynamic water bridge, during the ECC injection period. Otherwise these two components are disconnected from each other without any pipes inside the downcomer. The ECBD is an ECC downward isolation flow sub-channel which protects the ECC water from the high speed steam crossflow in the downcomer annulus during a LOCA event. The injected ECC water flows downward into the lower downcomer through the ECBD without a strong entrainment to a steam cross flow. The outer downcomer annulus of the ECBD is the major steam flow zone coming from the intact cold leg during a LBLOCA. During a DVI line break, the separated DVI nozzle and ECBD have the effect of preventing the level of the cooling water from being lowered in the downcomer due to an inlet-outlet reverse phenomenon at the lowest position of the outlet of the ECBD.

  8. Emotional Satisfaction of Customer Contacts

    OpenAIRE

    Güngör, Hüseyin

    2007-01-01

    For marketing and customer services researchers and professionals who are interested in customer contacts, customer satisfaction and loyalty issues. Contact centers are playing a pivotal role in customer services of the 21st century. Nevertheless, despite their growing importance and presence, contact centers are increasingly becoming the center for customer frustration, and frequently associated with negative comments in the media. Therefore, this research explores the Emotional, Cognitive, ...

  9. Contact Lens Related Corneal Ulcer

    OpenAIRE

    Loh, KY; P Agarwal

    2010-01-01

    A corneal ulcer caused by infection is one of the major causes of blindness worldwide. One of the recent health concerns is the increasing incidence of corneal ulcers associated with contact lens user especially if the users fail to follow specific instruction in using their contact lenses. Risk factors associated with increased risk of contact lens related corneal ulcers are: overnight wear, long duration of continuous wear, lower socio-economic classes, smoking, dry eye and poor hygiene. Th...

  10. Contact vitiligo: etiology and treatment

    OpenAIRE

    Singh P; Singh J; Agarwal U; Bhargava R

    2003-01-01

    Fifty patients of contact vitiligo were studied. EtiologicaI agents of contact vitiligo were identified by clinical history, distribution of lesions and patch testing with suspected material. All patients were advised to avoid the suspected agent and treated with PUVASOL and topical steroid. Out of 50 patients (Male 8%, Female 92% age 14-60 years)., etiological agent of contact vitiligo was found to be sticking bindi alone in 24 (48%), while bindi along with other etiolog...

  11. Children, contact and domestic abuse

    OpenAIRE

    Morrison, Fiona

    2014-01-01

    In recent years the issue of children’s contact with non-resident parents has been increasingly debated. The policy gaze has focused on contested contact when there are allegations of domestic abuse. Some commentators argue that in circumstances of domestic abuse, contact with an abusive father may not be in the ‘best interests’ of the child. To support these claims they point to evidence that domestic abuse adversely affects children, and domestic abuse often continues followi...

  12. Experimental and numerical investigation of contact-area-limited doping for top-contact pentacene thin-film transistors with Schottky contact.

    Science.gov (United States)

    Noda, Kei; Wada, Yasuo; Toyabe, Toru

    2015-10-28

    Effects of contact-area-limited doping for pentacene thin-film transistors with a bottom-gate, top-contact configuration were investigated. The increase in the drain current and the effective field-effect mobility was achieved by preparing hole-doped layers underneath the gold contact electrodes by coevaporation of pentacene and 2,3,5,6-tetrafluoro-7,7,8,8-tetracyanoquinodimethane (F4TCNQ), confirmed by using a thin-film organic transistor advanced simulator (TOTAS) incorporating Schottky contact with a thermionic field emission (TFE) model. Although the simulated electrical characteristics fit the experimental results well only in the linear regime of the transistor operation, the barrier height for hole injection and the gate-voltage-dependent hole mobility in the pentacene transistors were evaluated with the aid of the device simulation. This experimental data analysis with the simulation indicates that the highly-doped semiconducting layers prepared in the contact regions can enhance the charge carrier injection into the active semiconductor layer and concurrent trap filling in the transistor channel, caused by the mitigation of a Schottky energy barrier. This study suggests that both the contact-area-limited doping and the device simulation dealing with Schottky contact are indispensable in designing and developing high-performance organic thin-film transistors. PMID:24922359

  13. Elastic-properties measurement at high temperatures through contact resonance atomic force microscopy

    DEFF Research Database (Denmark)

    Marinello, Francesco; Pezzuolo, Andrea; Carmignato, Simone;

    2015-01-01

    . To this regard, some open issues are of particular interest: low depth of penetration, high lateral resolution and measurements at elevated temperatures. An interesting solution is given by acoustic microscopy techniques, which can be successfully implemented for advanced research in surface...... elasticity, allowing fast direct and non-destructive measurement of Young's modulus and related surface parameters.In this work an instrument set up for Contact Resonance Atomic Force Microscopy is proposed, where the sample with is coupled to a heating stage and a piezoelectric transducer directly vibrate...... the cantilever during scanning, in order to allow exploitation of high resolution measurements at relatively high temperatures. Such instrument set up was undergone a set of calibration experiments in order to allow not only qualitative but also quantitative characterization of surfaces. The work was...

  14. Ion Implanted Passivated Contacts for Interdigitated Back Contacted Solar Cells

    Energy Technology Data Exchange (ETDEWEB)

    Young, David L.; Nemeth, William; LaSalvia, Vincenzo; Reedy, Robert; Bateman, Nicholas; Stradins, Pauls

    2015-06-14

    We describe work towards an interdigitated back contacted (IBC) solar cell utilizing ion implanted, passivated contacts. Formation of electron and hole passivated contacts to n-type CZ wafers using tunneling SiO2 and ion implanted amorphous silicon (a-Si) are described. P and B were ion implanted into intrinsic amorphous Si films at several doses and energies. A series of post-implant anneals showed that the passivation quality improved with increasing annealing temperatures up to 900 degrees C. The recombination parameter, Jo, as measured by a Sinton lifetime tester, was Jo ~ 14 fA/cm2 for Si:P, and Jo ~ 56 fA/cm2 for Si:B contacts. The contact resistivity for the passivated contacts, as measured by TLM patterns, was 14 milliohm-cm2 for the n-type contact and 0.6 milliohm-cm2 for the p-type contact. These Jo and pcontact values are encouraging for forming IBC cells using ion implantation to spatially define dopants.

  15. A generalization of contact metric manifolds

    OpenAIRE

    Kim, J H; Park, J.H.; Sekigawa, K.

    2013-01-01

    We give a characterization of a contact metric manifold as a special almost contact metric manifold and discuss an almost contact metric manifold which is {a} natural generalization of the contact metric manifolds introduced by Y. Tashiro.

  16. CISM Course on Rolling Contact Phenomena

    CERN Document Server

    Kalker, Joost

    2000-01-01

    Preface.- Rolling Contact Phenomena - Linear Elasticity.- Finite Element Methods for Rolling Contact.- Plastic Deformation in Rolling Contact.- Non-Steady State Rolling Contact and Corrugations.- Modelling of Tyre Force and Moment Generation.- Rolling Noise.- Lubrication

  17. Advances in Non-contact Measurement of Creep Properties

    Science.gov (United States)

    Hyers, Robert W.; Canepari, Stacy; Rogers, Jan. R.

    2009-01-01

    Our team has developed a novel approach to measuring creep at extremely high temperatures using electrostatic levitation (ESL). This method has been demonstrated on niobium up to 2300 C, while ESL has melted tungsten (3400 C). High-precision machined spheres of the sample are levitated in the NASA MSFC ESL, a national user facility, and heated with a laser. The laser is aligned off-center so that the absorbed photons transfer their momentum to the sample, causing it to rotate at up to 250,000+ RPM. The rapid rotation loads the sample through centripetal acceleration, causing it to deform. The deformation of the sample is captured on high-speed video, which is analyzed by machine-vision software from the University of Massachusetts. The deformations are compared to finite element models to determine the constitutive constants in the creep relation. Furthermore, the noncontact method exploits stress gradients within the sample to determine the stress exponent in a single test. This method was validated in collaboration with the University of Tennessee for niobium at 1985 C, with agreement within the uncertainty of the conventional measurements. A similar method is being employed on Ultra-High-Temperature ZrB2- SiC composites, which may see application in rocket nozzles and sharp leading edges for hypersonic vehicles.

  18. Evaluation of residue-residue contact prediction in CASP10

    KAUST Repository

    Monastyrskyy, Bohdan

    2013-08-31

    We present the results of the assessment of the intramolecular residue-residue contact predictions from 26 prediction groups participating in the 10th round of the CASP experiment. The most recently developed direct coupling analysis methods did not take part in the experiment likely because they require a very deep sequence alignment not available for any of the 114 CASP10 targets. The performance of contact prediction methods was evaluated with the measures used in previous CASPs (i.e., prediction accuracy and the difference between the distribution of the predicted contacts and that of all pairs of residues in the target protein), as well as new measures, such as the Matthews correlation coefficient, the area under the precision-recall curve and the ranks of the first correctly and incorrectly predicted contact. We also evaluated the ability to detect interdomain contacts and tested whether the difficulty of predicting contacts depends upon the protein length and the depth of the family sequence alignment. The analyses were carried out on the target domains for which structural homologs did not exist or were difficult to identify. The evaluation was performed for all types of contacts (short, medium, and long-range), with emphasis placed on long-range contacts, i.e. those involving residues separated by at least 24 residues along the sequence. The assessment suggests that the best CASP10 contact prediction methods perform at approximately the same level, and comparably to those participating in CASP9.

  19. Contact allergy to epoxy resin

    DEFF Research Database (Denmark)

    Bangsgaard, Nannie; Thyssen, Jacob Pontoppidan; Menné, Torkil;

    2012-01-01

    . Objectives. To evaluate the prevalence of contact allergy to epoxy resin monomer (diglycidyl ether of bisphenol A; MW 340) among patients with suspected contact dermatitis and relate this to occupation and work-related consequences. Patients/methods. The dataset comprised 20 808 consecutive dermatitis...

  20. The importance of contact quality

    DEFF Research Database (Denmark)

    van Bakel, Marian; Gerritsen, Marinel; van Oudenhoven, Jan Pieter

    Establishing contact between expatriates and a local host has been found to reap benefits with regard to Interaction Adjustment, Host National Social Support, Open-mindedness, and Social Initiative. This longitudinal study examines the role of the quality of contact for these four aspects. Expatr...