WorldWideScience

Sample records for advanced current drive

  1. Predictions of fast wave heating, current drive, and current drive antenna arrays for advanced tokamaks

    Energy Technology Data Exchange (ETDEWEB)

    Batchelor, D.B.; Baity, F.W.; Carter, M.D. [and others

    1994-12-31

    The objective of the advanced tokamak program is to optimize plasma performance leading to a compact tokamak reactor through active, steady state control of the current profile using non-inductive current drive and profile control. To achieve these objectives requires compatibility and flexibility in the use of available heating and current drive systems--ion cyclotron radio frequency (ICRF), neutral beams, and lower hybrid. For any advanced tokamak, the following are important challenges to effective use of fast waves in various roles of direct electron heating, minority ion heating, and current drive: (1) to employ the heating and current drive systems to give self-consistent pressure and current profiles leading to the desired advanced tokamak operating modes; (2) to minimize absorption of the fast waves by parasitic resonances, which limit current drive; (3) to optimize and control the spectrum of fast waves launched by the antenna array for the required mix of simultaneous heating and current drive. The authors have addressed these issues using theoretical and computational tools developed at a number of institutions by benchmarking the computations against available experimental data and applying them to the specific case of TPX.

  2. Predictions of fast wave heating, current drive, and current drive antenna arrays for advanced tokamaks

    International Nuclear Information System (INIS)

    Batchelor, D.B.; Baity, F.W.; Carter, M.D.

    1994-01-01

    The objective of the advanced tokamak program is to optimize plasma performance leading to a compact tokamak reactor through active, steady state control of the current profile using non-inductive current drive and profile control. To achieve these objectives requires compatibility and flexibility in the use of available heating and current drive systems--ion cyclotron radio frequency (ICRF), neutral beams, and lower hybrid. For any advanced tokamak, the following are important challenges to effective use of fast waves in various roles of direct electron heating, minority ion heating, and current drive: (1) to employ the heating and current drive systems to give self-consistent pressure and current profiles leading to the desired advanced tokamak operating modes; (2) to minimize absorption of the fast waves by parasitic resonances, which limit current drive; (3) to optimize and control the spectrum of fast waves launched by the antenna array for the required mix of simultaneous heating and current drive. The authors have addressed these issues using theoretical and computational tools developed at a number of institutions by benchmarking the computations against available experimental data and applying them to the specific case of TPX

  3. Advanced induction motor drive control with single current sensor

    Directory of Open Access Journals (Sweden)

    Adžić Evgenije M.

    2016-01-01

    Full Text Available This paper proposes induction motor drive control method which uses minimal number of sensors, providing only DC-link current as a feedback signal. Improved DC-link current sampling scheme and modified asymmetrical switching pattern cancels characteristic waveform errors which exist in all three reconstructed motor line-currents. Motor linecurrent harmonic content is reduced to an acceptable level, eliminating torque and speed oscillations which were inherent for conventional single sensor drives. Consequently, use of single current sensor and line-current reconstruction technique is no longer acceptable only for low and medium performance drives, but also for drives where priority is obtaining a highly accurate, stable and fast response. Proposed control algorithm is validated using induction motor drive hardware prototype based on TMS320F2812 digital signal processor. [Projekat Ministarstva nauke Republike Srbije, br. III 042004 and by the Provincial Secretariat for Science and Technological Development of AP Vojvodina under contract No. 114-451-3508/2013-04

  4. First results on fast wave current drive in advanced tokamak discharges in DIII-D

    International Nuclear Information System (INIS)

    Prater, R.; Cary, W.P.; Baity, F.W.

    1995-07-01

    Initial experiments have been performed on the DIII-D tokamak on coupling, direct electron heating, and current drive by fast waves in advanced tokamak discharges. These experiments showed efficient central heating and current drive in agreement with theory in magnitude and profile. Extrapolating these results to temperature characteristic of a power plant (25 keV) gives current drive efficiency of about 0.3 MA/m 2

  5. Advanced antenna system for Alfven wave plasma heating and current drive in TCABR tokamak

    International Nuclear Information System (INIS)

    Ruchko, L.F.; Ozono, E.; Galvao, R.M.O.; Nascimento, I.C.; Degasperi, F.T.; Lerche, E.

    1998-01-01

    An advanced antenna system that has been developed for investigation of Alfven wave plasma heating and current drive in the TCABR tokamak is described. The main goal was the development of such a system that could insure the excitation of travelling single helicity modes with predefined wave mode numbers M and N. The system consists of four similar modules with poloidal windings. The required spatial spectrum is formed by proper phasing of the RF feeding currents. The impedance matching of the antenna with the four-phase oscillator is accomplished by resonant circuits which form one assembly unit with the RF feeders. The characteristics of the antenna system design with respect to the antenna-plasma coupling and plasma wave excitation, for different phasing of the feeding currents, are summarised. The antenna complex impedance Z=Z R +Z I is calculated taking into account both the plasma response to resonant excitation of fast Alfven waves and the nonresonant excitation of vacuum magnetic fields in conducting shell. The matching of the RF generator with the antenna system during plasma heating is simulated numerically, modelling the plasma response with mutually coupled effective inductances with corresponding active Z R and reactive Z I impedances. The results of the numerical simulation of the RF system performance, including both the RF magnetic field spectrum analysis and the modeling of the RF generator operation with plasma load, are presented. (orig.)

  6. Advanced launcher design options for electron cyclotron current drive on ITER based on remote steering

    NARCIS (Netherlands)

    Graswinckel, M. R.; Bongers, W. A.; M.R. de Baar,; van den Berg, M. A.; Denisov, G.; Donne, A. J. H.; Elzendoorn, B. S. Q.; Goede, A. P. H.; Heidinger, R.; Kuzikov, S.; Kruijt, O. G.; Kruizinga, B.; Moro, A.; Poli, E.; Ronden, D. M. S.; Saibene, G.; Thoen, D. J.; Verhoeven, A. G. A.

    2008-01-01

    Electron cyclotron current drive will become the main scheme on ITER for the stabilization of neoclassical tearing modes (NTMs) and the control of sawtooth oscillations. The effectiveness of this scheme forms the basis for the requirements of the ITER Upper Port Launcher. These requirements include

  7. Summary and viewgraphs from the Q-121 US/Japan advanced current drive concepts workshop

    International Nuclear Information System (INIS)

    Bonoli, P.; Porkolab, M.; Chan, V.; Pinsker, R.; Politzer, P.; Darrow, D.; Fukuyama, Atsushi; Imai, Tsuyoshi; Watari, Tetsuo; Itoh, Satoshi; Nakamura, Yukio; James, R.; Logan, G.; Porter, G.; Thomassen, K.; Lyon, J.; Mau, Tak; Tanaka, Hitoshi; Tanaka, Shigetoshi

    1990-01-01

    With the emphasis placed on current drive by ITER, which requires steady state operation in its engineering phase, it is important to bring theory and experiment in agreement for each of the schemes that could be used in that design. Both neutral beam and lower hybrid (LH) schemes are in excellent shape in that regard. Since the projected efficiency of all schemes is marginal it is also important to continue our search for more efficient processes. This workshop featured experimental and theoretical work in each processes. This workshop featured experimental and theoretical work in each of these areas, that is, validation of theory and the search for better ideas. There were a number of notable results to report, the most striking again (as with last year) the long pulse operation of TRIAM-1M. A low current was sustained for over 1 hour with LH waves, using new hall-effect sensors in the equilibrium field circuit to maintain position control. In JT-60, by sharpening the wave spectrum the current drive efficiency was improved to 0.34 x 10 20 m -2 A/W and 1.5 MA of current was driven entirely by the lower hybrid system. Also in that machine, using two different LH frequencies, the H-mode was entered. Finally, by using the LH system for startup they saved 2.5 resistive volt-sec of flux, which if extrapolated to ITER would save 40 volt-sec there. For the first time, and experiment on ECH current drive showed reasonable agreement with theory. Those experiments are reported here by James (LLNL) on the D3-D machine. Substantially lower ECH current drive than expected theoretically was observed on WT-3, but if differed by being in a low absorption regime. Nonetheless, excellent physics results were achieved in the WT-3 experiments, notably in having careful measurements of the parallel velocity distributions

  8. FED-A, an advanced performance FED based on low safety factor and current drive

    International Nuclear Information System (INIS)

    Peng, Y.K.M.; Rutherford, P.H.

    1983-08-01

    The FED-A study aims to quantify the potential improvement in cost-effectiveness of the Fusion Engineering Device (FED) by assuming low safety factor q (less than 2 as opposed to about 3) at the plasma edge and noninductive current drive (as opposed to only inductive current drive). The FED-A performance objectives are set to be : (1) ignition assuming International Tokamak Reactor (INTOR) plamsa confinement scaling, but still achieving a fusion power amplification Q greater than or equal to 5 when the confinement is degraded by a factor of 2; (2) neutron wall loading of about 1 MW/m 2 , with 0.5 MW/m 2 as a conservative lower bound; and (3) more clearly power-reactor-like operations, such as steady state

  9. Effect of Wave Accessibility on Lower Hybrid Wave Current Drive in Experimental Advanced Superconductor Tokamak with H-Mode Operation

    International Nuclear Information System (INIS)

    Li Xin-Xia; Xiang Nong; Gan Chun-Yun

    2015-01-01

    The effect of the wave accessibility condition on the lower hybrid current drive in the experimental advanced superconductor Tokamak (EAST) plasma with H-mode operation is studied. Based on a simplified model, a mode conversion layer of the lower hybrid wave between the fast wave branch and the slow wave branch is proved to exist in the plasma periphery for typical EAST H-mode parameters. Under the framework of the lower hybrid wave simulation code (LSC), the wave ray trajectory and the associated current drive are calculated numerically. The results show that the wave accessibility condition plays an important role on the lower hybrid current drive in EAST plasma. For wave rays with parallel refractive index n ‖ = 2.1 or n ‖ = 2.5 launched from the outside midplane, the wave rays may penetrate the core plasma due to the toroidal geometry effect, while numerous reflections of the wave ray trajectories in the plasma periphery occur. However, low current drive efficiency is obtained. Meanwhile, the wave accessibility condition is improved if a higher confined magnetic field is applied. The simulation results show that for plasma parameters under present EAST H-mode operation, a significant lower hybrid wave current drive could be obtained for the wave spectrum with peak value n ‖ = 2.1 if a toroidal magnetic field B T = 2.5 T is applied. (paper)

  10. Turbulent current drive mechanisms

    Science.gov (United States)

    McDevitt, Christopher J.; Tang, Xian-Zhu; Guo, Zehua

    2017-08-01

    Mechanisms through which plasma microturbulence can drive a mean electron plasma current are derived. The efficiency through which these turbulent contributions can drive deviations from neoclassical predictions of the electron current profile is computed by employing a linearized Coulomb collision operator. It is found that a non-diffusive contribution to the electron momentum flux as well as an anomalous electron-ion momentum exchange term provide the most efficient means through which turbulence can modify the mean electron current for the cases considered. Such turbulent contributions appear as an effective EMF within Ohm's law and hence provide an ideal means for driving deviations from neoclassical predictions.

  11. Study on lower hybrid current drive efficiency at high density towards long-pulse regimes in Experimental Advanced Superconducting Tokamak

    International Nuclear Information System (INIS)

    Li, M. H.; Ding, B. J.; Zhang, J. Z.; Gan, K. F.; Wang, H. Q.; Zhang, L.; Wei, W.; Li, Y. C.; Wu, Z. G.; Ma, W. D.; Jia, H.; Chen, M.; Yang, Y.; Feng, J. Q.; Wang, M.; Xu, H. D.; Shan, J. F.; Liu, F. K.; Peysson, Y.

    2014-01-01

    Significant progress on both L- and H-mode long-pulse discharges has been made recently in Experimental Advanced Superconducting Tokamak (EAST) with lower hybrid current drive (LHCD) [J. Li et al., Nature Phys. 9, 817 (2013) And B. N. Wan et al., Nucl. Fusion 53, 104006 (2013).]. In this paper, LHCD experiments at high density in L-mode plasmas have been investigated in order to explore possible methods of improving current drive (CD) efficiency, thus to extend the operational space in long-pulse and high performance plasma regime. It is observed that the normalized bremsstrahlung emission falls much more steeply than 1/n e-av (line-averaged density) above n e-av  = 2.2 × 10 19  m −3 indicating anomalous loss of CD efficiency. A large broadening of the operating line frequency (f = 2.45 GHz), measured by a radio frequency (RF) probe located outside the EAST vacuum vessel, is generally observed during high density cases, which is found to be one of the physical mechanisms resulting in the unfavorable CD efficiency. Collisional absorption of lower hybrid wave in the scrape off layer (SOL) may be another cause, but this assertion needs more experimental evidence and numerical analysis. It is found that plasmas with strong lithiation can improve CD efficiency largely, which should be benefited from the changes of edge parameters. In addition, several possible methods are proposed to recover good efficiency in future experiments for EAST

  12. Noninductive current drive in tokamaks

    International Nuclear Information System (INIS)

    Uckan, N.A.

    1985-01-01

    Various current drive mechanisms may be grouped into four classes: (1) injection of energetic particle beams; (2) launching of rf waves; (3) hybrid schemes, which are combinations of various rf schemes (rf plus beams, rf and/or beam plus ohmic heating, etc.); and (4) other schemes, some of which are specific to reactor plasma conditions requiring the presence of alpha particle or intense synchrotron radiation. Particle injection schemes include current drive by neutral beams and relativistic electron beams. The rf schemes include current drive by the lower hybrid (LH) waves, the electron waves, the waves in the ion cyclotron range of frequencies, etc. Only a few of these approaches, however, have been tested experimentally, with the broadest data base available for LH waves. Included in this report are (1) efficiency criteria for current drive, (2) current drive by neutral beam injection, (3) LH current drive, (4) electron cyclotron current drive, (5) current drive by ion cyclotron waves - minority species heating, and (6) current drive by other schemes (such as hybrids and low frequency waves)

  13. Synergy in RF Current Drive

    International Nuclear Information System (INIS)

    Dumont, R.J.; Giruzzi, G.

    2005-01-01

    Auxiliary methods for efficient non-inductive current drive in tokamaks generally involve the interaction of externally driven waves with superthermal electrons. Among the possible schemes, Lower Hybrid (LH) and Electron Cyclotron (EC) current drive have been so far the most successful. An interesting aspect of their combined use is the fact that since they involve possibly overlapping domains in velocity and configuration spaces, a synergy between them is expected for appropriate parameters. The signature of this effect, significant improvement of the EC current drive efficiency, results from a favorable interplay of the quasilinear diffusions induced by both waves. Recently, improvements of the EC current drive efficiency in the range of 2-4 have been measured in fully non-inductive discharges in the Tore Supra tokamak, providing the first clear evidence of this effect in steady-state conditions. We present here the experimental aspects of these discharges. The associated kinetic modeling and current state of understanding of the LH-EC synergy phenomenon are also discussed. (authors)

  14. Synergy in RF Current Drive

    International Nuclear Information System (INIS)

    Dumont, R.J.; Giruzzi, G.

    2005-01-01

    Auxiliary methods for efficient non-inductive current drive in tokamaks generally involve the interaction of externally driven waves with superthermal electrons. Among the possible schemes, Lower Hybrid (LH) and Electron Cyclotron (EC) current drive have been so far the most successful. An interesting aspect of their combined use is the fact that since they involve possibly overlapping domains in velocity and configuration spaces, a synergy between them is expected for appropriate parameters. The signature of this effect, significant improvement of the EC current drive efficiency, results from a favorable interplay of the quasilinear diffusions induced by both waves. Recently, improvements of the EC current drive efficiency in the range of 2-4 have been measured in fully non-inductive discharges in the Tore Supra tokamak, providing the first clear evidence of this effect in steady-state conditions. We present here the experimental aspects of these discharges. The associated kinetic modeling and current state of understanding of the LH-EC synergy phenomenon are also discussed

  15. Current drive for rotamak plasmas

    Indian Academy of Sciences (India)

    Abstract. Experiments which have been undertaken over a number of years have shown that a rotating magnetic field can drive a significant non-linear Hall current in a plasma. Successful experiments of this concept have been made with a device called rotamak. In its original configuration this device was a field reversed ...

  16. Current challenges in autonomous driving

    Science.gov (United States)

    Barabás, I.; Todoruţ, A.; Cordoş, N.; Molea, A.

    2017-10-01

    Nowadays the automotive industry makes a quantum shift to a future, where the driver will have smaller and smaller role in driving his or her vehicle ending up being totally excluded. In this paper, we have investigated the different levels of driving automatization, the prospective effects of these new technologies on the environment and traffic safety, the importance of regulations and their current state, the moral aspects of introducing these technologies and the possible scenarios of deploying the autonomous vehicles. We have found that the self-driving technologies are facing many challenges: a) They must make decisions faster in very diverse conditions which can include many moral dilemmas as well; b) They have an important potential in reducing the environmental pollution by optimizing their routes, driving styles by communicating with other vehicles, infrastructures and their environment; c) There is a considerable gap between the self-drive technology level and the current regulations; fortunately, this gap shows a continuously decreasing trend; d) In case of many types of imminent accidents management there are many concerns about the ability of making the right decision. Considering that this field has an extraordinary speed of development, our study is up to date at the submission deadline. Self-driving technologies become increasingly sophisticated and technically accessible, and in some cases, they can be deployed for commercial vehicles as well. According to the current stage of research and development, it is still unclear how the self-driving technologies will be able to handle extreme and unexpected events including their moral aspects. Since most of the traffic accidents are caused by human error or omission, it is expected that the emergence of the autonomous technologies will reduce these accidents in their number and gravity, but the very few currently available test results have not been able to scientifically underpin this issue yet. The

  17. Stability, current drive and heating, energetic particles

    International Nuclear Information System (INIS)

    Razumova, K.

    2001-01-01

    The paper summarizes the results presented at the conference Fusion Energy 2000 (FEC 2000) in relation to the following subjects: 1. The possibility of realizing plasma parameters for ITER needs, advanced regimes in tokamaks and stellarators. 2. Stability of plasmas with an appreciable component of fast particles. 3. Low aspect ratio tokamaks. 4. New results with auxiliary heating and current drive methods. 5. β limit and neoclassical tearing mode (NTM) stabilization. 6. Internal transport barriers. (author)

  18. Motion feedback in advanced driving manoeuvres

    NARCIS (Netherlands)

    Correia Grácio, B.; Wentink, M.; Feenstra, P.J; Mulder, M.; Paassen M.M. van; Bles, W.

    2009-01-01

    During advanced driving manoeuvres, drivers can be hypothesized to use all the available cues to optimize their performance. Fixed-base simulators are commonly used for training of these advanced driving manoeuvres, despite the fact that motion cues are not present. In this experiment we hypothesize

  19. Lower hybrid current drive in shaped tokamaks

    International Nuclear Information System (INIS)

    Kesner, J.

    1993-01-01

    A time dependent lower hybrid current drive tokamak simulation code has been developed. This code combines the BALDUR tokamak simulation code and the Bonoli/Englade lower hybrid current drive code and permits the study of the interaction of lower hybrid current drive with neutral beam heating in shaped cross-section plasmas. The code is time dependent and includes the beam driven and bootstrap currents in addition to the current driven by the lower hybrid system. Examples of simulations are shown for the PBX-M experiment which include the effect of cross section shaping on current drive, ballooning mode stabilization by current profile control and sawtooth stabilization. A critical question in current drive calculations is the radial transport of the energetic electrons. The authors have developed a response function technique to calculate radial transport in the presence of an electric field. The consequences of the combined influences of radial diffusion and electric field acceleration are discussed

  20. Current drive for rotamak plasmas

    Indian Academy of Sciences (India)

    toroidal fields. It is clear that the current driven may depend on the actual experi- mental situation and that increasing either of these fields may not necessarily lead to better performance. Acknowledgement. The author acknowledges the financial support provided through the Australian. Research Council and the Australian ...

  1. High Field Side Lower Hybrid Current Drive Simulations for Off- axis Current Drive in DIII-D

    Science.gov (United States)

    Wukitch, S. J.; Shiraiwa, S.; Wallace, G. M.; Bonoli, P. T.; Holcomb, C.; Pinsker, R. I.

    2017-10-01

    Efficient off-axis current drive scalable to reactors is a key enabling technology for developing economical, steady state tokamak. Previous studies have focussed on high field side (HFS) launch of lower hybrid current drive (LHCD) in double null configurations in reactor grade plasmas and found improved wave penetration and high current drive efficiency with driven current profile peaked near a normalized radius, ρ, of 0.6-0.8, consistent with advanced tokamak scenarios. Further, HFS launch potentially mitigates plasma material interaction and coupling issues. For this work, we sought credible HFS LHCD scenario for DIII-D advanced tokamak discharges through utilizing advanced ray tracing and Fokker Planck simulation tools (GENRAY+CQL3D) constrained by experimental considerations. For a model and existing discharge, HFS LHCD scenarios with excellent wave penetration and current drive were identified. The LHCD is peaked off axis, ρ˜0.6-0.8, with FWHM Δρ=0.2 and driven current up to 0.37 MA/MW coupled. For HFS near mid plane launch, wave penetration is excellent and have access to single pass absorption scenarios for variety of plasmas for n||=2.6-3.4. These DIII-D discharge simulations indicate that HFS LHCD has potential to demonstrate efficient off axis current drive and current profile control in DIII-D existing and model discharge.

  2. Current drive in high density tokamak plasma

    International Nuclear Information System (INIS)

    Sakaguchi, Seiichiro; Jotaki, Eriko; Kawasaki, Shoji; Moriyama, Shin-ichi; Nagao, Akihiro; Nakamura, Kazuo; Nakamura, Yukio; Hiraki, Naoki; Itoh, Satoshi

    1989-01-01

    Current drive in high density tokamak plasma is investigated, with special attention given to mode conversion and proximity conditions that characterize the propagation of electromagnetic waves in the case of current drive by lower hybrid waves. A simple model is used to evaluate the current drive efficiency, and its dependence on various parameters associated with equipment is investigated to provide information required in designing experimental equipment. A strong troidal magnetic field is necessary to produce high density plasma, and incident electromagnetic waves should have a high frequency to prevent the mode conversion, suggesting that a high frequency and a strong troidal field are essential to permit desirable propagation of incident electromagnetic waves. The evaluation of the current drive efficiency shows that the proximity conditions and the power spectrum of the lower hybrid waves entering the plasma are of importance. The average refraction factor in the direction of the troidal field should be larger than but close to that determined from the proximity conditions in order to increase the drive efficiency. As the intensity of the troidal field increases, the refraction factor determined from the proximity conditions decreases, leading to an increase in the drive efficiency. (N.K.)

  3. Stability, energetic particles, waves, and current drive summary

    International Nuclear Information System (INIS)

    Stambaugh, R.D.

    2005-01-01

    This is the summary paper for the subjects of plasma stability, energetic particles, waves, and current drive for the 20th IAEA Fusion Energy Conference, 1-6 November 2004, Vilamoura, Portugal. Material summarized herein was drawn from 65 contributed papers and 21 overview papers. The distribution of contributed papers by subjects is shown. Significant advances were reported on the principal instabilities in magnetically confined plasmas, even looking forward to the burning plasma state. Wave-plasma physics is maturing and novel methods of current drive and noninductive current generation are being developed. (author)

  4. Electron cyclotron resonance heating and current drive

    Energy Technology Data Exchange (ETDEWEB)

    Fidone, I.; Castejon, F.

    1992-07-01

    A brief summary of the theory and experiments on electron- cyclotron heating and current drive is presented. The general relativistic formulation of wave propagation and linear absorption is considered in some detail. The O-mode and the X-mode for normal and oblique propagation are investigated and illustrated by several examples. The experimental verification of the theory in T-10 and D- III-D is briefly discussed. Quasilinear evolution of the momentum distribution and related applications as, for instance, non linear wave, damping and current drive, are also considered for special cases of wave frequencies, polarization and propagation. In the concluding section we present the general formulation of the wave damping and current drive in the absence of electron trapping for arbitrary values of the wave frequency. (Author) 13 refs.

  5. Electron - cyclotron resonance heating and current drive

    International Nuclear Information System (INIS)

    Fidone, I.; Castejon, F.

    1992-01-01

    A brief summary of the theory and experiments on electron- cyclotron heating and current drive is presented. The general relativistic formulation of wave propagation and linear absorption is considered in some detail. The O-mode and the X-mode for normal and oblique propagation are investigated and illustrated by several examples. The experimental verification of the theory in T-10 and D- III-D is briefly discussed. Quasilinear evolution of the momentum distribution and related applications as, for instance, non linear wave, damping and current drive, are also considered for special cases of wave frequencies, polarization and propagation. In the concluding section we present the general formulation of the wave damping and current drive in the absence of electron trapping for arbitrary values of the wave frequency. (Author) 13 refs

  6. Fast wave current drive system design for DIII-D

    Energy Technology Data Exchange (ETDEWEB)

    deGrassie, J.S.; Callis, R.; Lin-Liu, Y.R.; Moeller, C..; Petty, C.C.; Phelps, D.R.; Pinsker, R.I.; Remsen, D. (General Atomics, San Diego, CA (United States)); Baity, F.W.; Hoffman, D.J.; Taylor, D.J. (Oak Ridge National Lab., TN (United States)); Arnold, W.; Martin, S. (ANT-Nachrichtentechnik GmbH, Backnang (Germany))

    1992-09-01

    DIII-D has a major effort underway to develop the physics and technology of fast wave electron heating and current drive in conjunction with electron cyclotron heating. The present system consists of a four strap antenna driven by one 2 MW transmitter in the 32--60 MHz band. Experiments have been successful in demonstrating the physics of heating and current drive. In order to validate fast wave current drive for future machines a greater power capability is necessary to drive all of the plasma current. Advanced tokamak modeling for DIII-D has indicated that this goal can be met for plasma configurations of interest (i.e. high [beta] VH-mode discharges) with 8 MW of transmitter fast wave capability. It is proposed that four transmitters drive fast wave antennas at three locations in DIII-D to provide the power for current drive and current profile modification. As the next step in acquiring this capability, two modular four strap antennas are in design and the procurement of a high power transmitter in the 30--120 MHz range is in progress. Additionally, innovations in the technology are being investigated, such as the use of a coupled combine antenna to reduce the number of required feedthroughs and to provide for parallel phase velocity variation with a relatively small change in frequency, and the use of fast ferrite tuners to provide millisecond timescale impedance matching. A successful test of a low power fast ferrite prototype was conducted on DIII-D.

  7. Fast wave current drive system design for DIII-D

    Energy Technology Data Exchange (ETDEWEB)

    deGrassie, J.S.; Callis, R.; Lin-Liu, Y.R.; Moeller, C..; Petty, C.C.; Phelps, D.R.; Pinsker, R.I.; Remsen, D. [General Atomics, San Diego, CA (United States); Baity, F.W.; Hoffman, D.J.; Taylor, D.J. [Oak Ridge National Lab., TN (United States); Arnold, W.; Martin, S. [ANT-Nachrichtentechnik GmbH, Backnang (Germany)

    1992-09-01

    DIII-D has a major effort underway to develop the physics and technology of fast wave electron heating and current drive in conjunction with electron cyclotron heating. The present system consists of a four strap antenna driven by one 2 MW transmitter in the 32--60 MHz band. Experiments have been successful in demonstrating the physics of heating and current drive. In order to validate fast wave current drive for future machines a greater power capability is necessary to drive all of the plasma current. Advanced tokamak modeling for DIII-D has indicated that this goal can be met for plasma configurations of interest (i.e. high {beta} VH-mode discharges) with 8 MW of transmitter fast wave capability. It is proposed that four transmitters drive fast wave antennas at three locations in DIII-D to provide the power for current drive and current profile modification. As the next step in acquiring this capability, two modular four strap antennas are in design and the procurement of a high power transmitter in the 30--120 MHz range is in progress. Additionally, innovations in the technology are being investigated, such as the use of a coupled combine antenna to reduce the number of required feedthroughs and to provide for parallel phase velocity variation with a relatively small change in frequency, and the use of fast ferrite tuners to provide millisecond timescale impedance matching. A successful test of a low power fast ferrite prototype was conducted on DIII-D.

  8. Current drive for spherical tokamak plasmas

    International Nuclear Information System (INIS)

    Storer, R.

    1999-01-01

    Very low aspect ratio spherical tokamaks have proved to have some very useful and remarkable properties including very high values of the plasma pressure to magnetic field pressure. Following the construction of the Start tokamak, a number of such configurations have been constructed. One of the difficulties encountered is in providing sufficient inductive current drive due to the competing requirements of the need to keep the aspect ratio low and providing the space for the central current-carrying rod with an internal inductive coil. An alternative current drive technique would be very useful. In a parallel development it has been shown that a rotating magnetic field can drive a significant non-linear Hall current in a spherical plasma. Successful experiments of this concept have been made with a device called the Rotamak. In its original configuration this device was a field reversed configuration without a toroidal magnetic field but with a vertical field to establish the magnetic hydrodynamical equilibrium. However, recent modifications have shown that increased current can be driven if a central current-carrying rod is used to provide an applied toroidal field. The new Rotamak has then a spherical tokamak magnetic field structure. This work will present new calculations which model the above structure and include the effect of the applied toroidal field in addition to the steady vertical field and the rotating (current-drive) magnetic field. The problem is fully three dimensional and non-linear and involves the application of interesting computational techniques. The potential of using the rotating field current drive technique for spherical tokamaks will be evaluated

  9. Theory of beat-wave current drive

    Energy Technology Data Exchange (ETDEWEB)

    Mendonca, J.T.; Galvao, R.M.O.

    1986-06-01

    The beat-wave scheme for current drive is studied in the frame of plasma weak-turbulence theory. The value of the driven current is limited by a quasi-linear diffusion mechanism. The one-dimensional problem, corresponding to the resonant excitation of electron plasma oscillations by two beating electro-magnetic beams is discussed in detail. The results may be relevant to the continuous operation of tokamak discharges.

  10. Comments on ICRH current drive in JET

    International Nuclear Information System (INIS)

    Fried, B.; Hellsten, T.; Moreau, D.

    1989-01-01

    To study current drive via the mode-converted slow wave during ICRH an assessment for which plasma compositions and wave number mode conversion from the magnetosonic wave to the slow wave can dominate is made. A simple slab model is used to investigate the competition between mode conversion and minority cyclotron absorption for a deuterium plasma with H + and 3 He 2+ minority species in JET. A 3 He 2+ minority should be more appropriate for mode conversion current drive than H + because the 3 He 2+ concentration can be chosen near its optimum for the ''Budden absorption'' without bringing the ion hybrid resonance and the cyclotron resonance so close that the minority absorption dominates. 3 He 2+ minority also allows operation at toroidal numbers which are characteristic of present JET antennae. (author)

  11. Disturbance observer based current controller for vector controlled IM drives

    DEFF Research Database (Denmark)

    Teodorescu, Remus; Dal, Mehmet

    2008-01-01

    In order to increase the accuracy of the current control loop, usually, well known parameter compensation and/or cross decoupling techniques are employed for advanced ac drives. In this paper, instead of using these techniques an observer-based current controller is proposed for vector controlled...... induction motor (IM) drives. The control design, based on synchronously rotating d-q frame model of the machine, has a simple structure that combines the proportional portion of a conventional PI control and output of the observer. The observer is predicted to estimate the disturbances caused by parameters...... change in current control loop and, also to remove undesired cross coupling existing between components of the stator current. The observer uses the measured stator currents and estimated PWM voltages, and produces a disturbance signal with a low pass filter. The proposed control scheme reduces cross...

  12. Advanced and intelligent control in power electronics and drives

    CERN Document Server

    Blaabjerg, Frede; Rodríguez, José

    2014-01-01

    Power electronics and variable frequency drives are continuously developing multidisciplinary fields in electrical engineering, and it is practically not possible to write a book covering the entire area by one individual specialist. Especially by taking account the recent fast development in the neighboring fields like control theory, computational intelligence and signal processing, which all strongly influence new solutions in control of power electronics and drives. Therefore, this book is written by individual key specialist working on the area of modern advanced control methods which penetrates current implementation of power converters and drives. Although some of the presented methods are still not adopted by industry, they create new solutions with high further research and application potential. The material of the book is presented in the following three parts: Part I: Advanced Power Electronic Control in Renewable Energy Sources (Chapters 1-4), Part II: Predictive Control of Power Converters and D...

  13. Fast wave current drive on DIII-D

    Energy Technology Data Exchange (ETDEWEB)

    deGrassie, J.S.; Petty, C.C.; Pinsker, R.I. [and others

    1995-07-01

    The physics of electron heating and current drive with the fast magnetosonic wave has been demonstrated on DIII-D, in reasonable agreement with theoretical modeling. A recently completed upgrade to the fast wave capability should allow full noninductive current drive in steady state advanced confinement discharges and provide some current density profile control for the Advanced Tokamak Program. DIII-D now has three four-strap fast wave antennas and three transmitters, each with nominally 2 MW of generator power. Extensive experiments have been conducted with the first system, at 60 MHz, while the two newer systems have come into operation within the past year. The newer systems are configured for 60 to 120 MHz. The measured FWCD efficiency is found to increase linearly with electron temperature as {gamma} = 0.4 {times} 10{sup 18} T{sub eo} (keV) [A/m{sup 2}W], measured up to central electron temperature over 5 keV. A newly developed technique for determining the internal noninductive current density profile gives efficiencies in agreement with this scaling and profiles consistent with theoretical predictions. Full noninductive current drive at 170 kA was achieved in a discharge prepared by rampdown of the Ohmic current. Modulation of microwave reflectometry signals at the fast wave frequency is being used to investigate fast wave propagation and damping. Additionally, rf pick-up probes on the internal boundary of the vessel provide a comparison with ray tracing codes, with dear evidence for a toroidally directed wave with antenna phasing set for current drive. There is some experimental evidence for fast wave absorption by energetic beam ions at high cyclotron harmonic resonances.

  14. Fast wave current drive on DIII-D

    International Nuclear Information System (INIS)

    deGrassie, J.S.; Petty, C.C.; Pinsker, R.I.; Forest, C.B.; Ikezi, H.; Prater, R.; Baity, F.W.; Callis, R.W.; Cary, W.P.; Chiu, S.C.; Doyle, E.J.; Ferguson, S.W.; Hoffman, D.J.; Jaeger, E.F.; Kim, K.W.; Lee, J.H.; Lin-Liu, Y.R.; Murakami, M.; ONeill, R.C.; Porkolab, M.; Rhodes, T.L.; Swain, D.W.

    1996-01-01

    The physics of electron heating and current drive with the fast magnetosonic wave has been demonstrated on DIII-D, in reasonable agreement with theoretical modeling. A recently completed upgrade to the fast wave capability should allow full noninductive current drive in steady state advanced confinement discharges and provide some current density profile control for the Advanced Tokamak Program. DIII-D now has three four-strap fast wave antennas and three transmitters, each with nominally 2 MW of generator power. Extensive experiments have been conducted with the first system, at 60 MHz, while the two newer systems have come into operation within the past year. The newer systems are configured for 60 to 120 MHz. The measured FWCD efficiency is found to increase linearly with electron temperature as γ=0.4x10 18 T e0 (keV) [A/m 2 W], measured up to central electron temperature over 5 keV. A newly developed technique for determining the internal noninductive current density profile gives efficiencies in agreement with this scaling and profiles consistent with theoretical predictions. Full noninductive current drive at 170 kA was achieved in a discharge prepared by rampdown of the Ohmic current. Modulation of microwave reflectometry signals at the fast wave frequency is being used to investigate fast wave propagation and damping. Additionally, rf pick-up probes on the internal boundary of the vessel provide a comparison with ray tracing codes, with clear evidence for a toroidally directed wave with antenna phasing set for current drive. copyright 1996 American Institute of Physics

  15. Fast wave current drive on DIII-D

    International Nuclear Information System (INIS)

    deGrassie, J.S.; Petty, C.C.; Pinsker, R.I.

    1995-01-01

    The physics of electron heating and current drive with the fast magnetosonic wave has been demonstrated on DIII-D, in reasonable agreement with theoretical modeling. A recently completed upgrade to the fast wave capability should allow full noninductive current drive in steady state advanced confinement discharges and provide some current density profile control for the Advanced Tokamak Program. DIII-D now has three four-strap fast wave antennas and three transmitters, each with nominally 2 MW of generator power. Extensive experiments have been conducted with the first system, at 60 MHz, while the two newer systems have come into operation within the past year. The newer systems are configured for 60 to 120 MHz. The measured FWCD efficiency is found to increase linearly with electron temperature as γ = 0.4 x 10 18 T eo (keV) [A/m 2 W], measured up to central electron temperature over 5 keV. A newly developed technique for determining the internal noninductive current density profile gives efficiencies in agreement with this scaling and profiles consistent with theoretical predictions. Full noninductive current drive at 170 kA was achieved in a discharge prepared by rampdown of the Ohmic current. Modulation of microwave reflectometry signals at the fast wave frequency is being used to investigate fast wave propagation and damping. Additionally, rf pick-up probes on the internal boundary of the vessel provide a comparison with ray tracing codes, with dear evidence for a toroidally directed wave with antenna phasing set for current drive. There is some experimental evidence for fast wave absorption by energetic beam ions at high cyclotron harmonic resonances

  16. Current drive in spherical tokamak plasmas

    International Nuclear Information System (INIS)

    Storer, R.

    1999-01-01

    The early experiments on a spherical rotamak showed that a rotating magnetic field could be used to drive substantial currents and create a compact torus magnetic field configuration. The theoretical analysis of the spherical rotamak has been essentially confined to this class. Recent experiments on the Flinders Rotamak-ST have included a toroidal field, produced by a current-carrying central rod, with encouraging results; for it has been shown that an enhanced current can be driven with this configuration which is the equivalent of a spherical tokamak. This paper will be devoted to a theoretical and computational analysis of this situation. We use a model where the rotating magnetic field is applied to a spherical plasma, with the rotating field oriented parallel to the equatorial plane, taken to be the x-y plane. In our model the ions form a uniform background and the frequency of the rotating Held is very much less than the electron cyclotron frequency (with respect to the rotating field strength) and very much greater than the ion cyclotron frequency. This condition is satisfied by the rotamak experiments

  17. Current Drive in a Ponderomotive Potential with Sign Reversal

    International Nuclear Information System (INIS)

    Fisch, N.J.; Rax, J.M.; Dodin, I.Y.

    2003-01-01

    Noninductive current drive can be accomplished through ponderomotive forces with high efficiency when the potential changes sign over the interaction region. The effect can practiced upon both ions and electrons. The current drive efficiencies, in principle, might be higher than those possible with conventional radio-frequency current-drive techniques, since different considerations come into play

  18. Advanced insulated gate bipolar transistor gate drive

    Science.gov (United States)

    Short, James Evans [Monongahela, PA; West, Shawn Michael [West Mifflin, PA; Fabean, Robert J [Donora, PA

    2009-08-04

    A gate drive for an insulated gate bipolar transistor (IGBT) includes a control and protection module coupled to a collector terminal of the IGBT, an optical communications module coupled to the control and protection module, a power supply module coupled to the control and protection module and an output power stage module with inputs coupled to the power supply module and the control and protection module, and outputs coupled to a gate terminal and an emitter terminal of the IGBT. The optical communications module is configured to send control signals to the control and protection module. The power supply module is configured to distribute inputted power to the control and protection module. The control and protection module outputs on/off, soft turn-off and/or soft turn-on signals to the output power stage module, which, in turn, supplies a current based on the signal(s) from the control and protection module for charging or discharging an input capacitance of the IGBT.

  19. Fast wave current drive above the slow wave density limit

    International Nuclear Information System (INIS)

    McWilliams, R.; Sheehan, D.P.; Wolf, N.S.; Edrich, D.

    1989-01-01

    Fast wave and slow wave current drive near the mean gyrofrequency were compared in the Irvine Torus using distinct phased array antennae of similar principal wavelengths, frequencies, and input powers. The slow wave current drive density limit was measured for 50ω ci ≤ω≤500ω ci and found to agree with trends in tokamaks. Fast wave current drive was observed at densities up to the operating limit of the torus, demonstrably above the slow wave density limit

  20. Mechanisms of the negative synergy effect between electron cyclotron current drive and lower hybrid current drive in tokamak

    International Nuclear Information System (INIS)

    Chen Shaoyong; Hong Binbin; Tang Changjian; Yang Wen; Zhang Xinjun

    2013-01-01

    The synergy current drive by combining electron cyclotron wave (ECW) with lower hybrid wave (LHW) can be used to either increase the noninductive current drive efficiency or shape the plasma current profile. In this paper, the synergy current drive by ECW and LHW is studied with numerical simulation. The nonlinear relationship between the wave powers and the synergy current of ECW and LHW is revealed. When the LHW power is small, the synergy current reduces as the ECW power increases, and the synergy current is even reduced to lower than zero, which is referred as negative synergy in the this context. Research shows that the mechanism of the negative synergy is the peaking effect of LHW power profile and the trapped electrons effect. The present research is helpful for understanding the physics of synergy between electron cyclotron current drive and lower hybrid current drive, it can also instruct the design of experiments. (authors)

  1. Theoretical studies of non inductive current drive in compact toroids

    NARCIS (Netherlands)

    Farengo, R; Lifschitz, AF; Caputi, KI; Arista, NR; Clemente, RA

    Three non inductive current drive methods that can be applied to compact toroids axe studied. The use of neutral beams to drive current in field reversed configurations and spheromaks is studied using a Monte Carlo code that includes a complete ionization package and follows the exact particle

  2. Current deposition profiles in advanced geometries

    International Nuclear Information System (INIS)

    Wright, J.C.; Phillips, C.K.; Bonoli, P.T.

    1997-01-01

    In advanced toroidal devices, plasma shaping can have a significant effect on quantities of interest, including the radio frequency (RF) deposited power and current. Most 2D RF modeling codes use a parameterization of current drive efficiencies to calculate fast wave driven currents. This parameterization is derived from a ray-tracing model in a low-beta model equilibrium. There are difficulties in applying it to a spectrum of waves, and it cannot account for multiple resonances and coherency effects between the electrons and the waves. By evaluating a formulation of the quasilinear diffusion coefficient in an arbitrary inhomogenous geometry with the fields from a full wave code, we address the effects of wave spectra, plasma inhomogeneity, and plasma profile on the evaluation of current deposition profiles. Current profiles are calculated directly from the quasilinear diffusion using the adjoint formulation, with the magnetic equilibrium specified consistently in both the adjoint routine and the full wave code. Results are benchmarked by comparing a power deposition calculation from conductivity to one from the quasilinear expression. RF driven current profiles for various devices, including tokamaks with different aspect ratios, will be presented. copyright 1997 American Institute of Physics

  3. Theory of current-drive in plasmas

    Energy Technology Data Exchange (ETDEWEB)

    Fisch, N.J.

    1986-12-01

    The continuous operation of a tokamak fusion reactor requires, among other things, a means of providing continuous toroidal current. Such operation is preferred to the conventional pulsed operation, where the plasma current is induced by a time-varying magnetic field. A variety of methods has been proposed to provide continuous current, including methods which utilize particle beams or radio frequency waves in any of several frequency regimes. Currents as large as half a mega-amp have now been produced in the laboratory by such means, and experimentation in these techniques has now involved major tokamak facilities worldwide.

  4. Theory of current-drive in plasmas

    International Nuclear Information System (INIS)

    Fisch, N.J.

    1986-12-01

    The continuous operation of a tokamak fusion reactor requires, among other things, a means of providing continuous toroidal current. Such operation is preferred to the conventional pulsed operation, where the plasma current is induced by a time-varying magnetic field. A variety of methods has been proposed to provide continuous current, including methods which utilize particle beams or radio frequency waves in any of several frequency regimes. Currents as large as half a mega-amp have now been produced in the laboratory by such means, and experimentation in these techniques has now involved major tokamak facilities worldwide

  5. Transport effects on current drive efficiency and localisation

    International Nuclear Information System (INIS)

    Cox, M.; McKenzie, J.S.; O'Brien, M.R.

    1990-01-01

    In this paper we discuss the effects of radial transport of electrons on the efficiency and profiles of a radiofrequency and Ohmic current drive in tokamaks. It has been recognised theoretically and experimentally that such processes can reduce the potential current drive efficiency of both Lower Hybrid (LH) and Electron Cyclotron Resonance Heating (ECRH) in tokamaks in which the energy confinement time (τ E ) is comparable with or less than the collision time of the heated electrons. Also, even in tokamaks in which this condition is not satisfied, radial transport can broaden the driven current profile and perhaps limit the effectiveness of the use of current drive for tailoring the current profile to control localised MHD modes. Here we solve numerically for the perturbed current-carrying component of the electron distribution function produced by balancing collisional, heating and transport processes. Three cases are considered: current drive by LH waves, the ECRH current drive experiments on CLEO in which the discrepancy between observed and predicted driven current was attributed to these effects; and the effect on Ohmic current drive. (author) 7 refs., 4 figs

  6. High Harmonic Fast Wave heating and current drive for NSTX

    Science.gov (United States)

    Robinson, J. A.; Majeski, R.; Hosea, J.; Menard, J.; Ono, M.; Phillips, C. K.; Wilson, J. R.; Wright, J.; Batchelor, D. B.; Carter, M. D.; Jaeger, E. F.; Ryan, P.; Swain, D.; Mau, T. K.; Chiu, S. C.; Smithe, D.

    1997-11-01

    Heating and noninductive current drive in NSTX will initially use 6 MW of rf power in the high harmonic fast wave (HHFW) regime. We present numerical modelling of HHFW heating and current drive in NSTX using the PICES, CURRAY, FISIC, and METS95 codes. High electron β during the discharge flattop in NSTX is predicted to result in off-axis power deposition and current drive. However, reductions in the trapped electron fraction (due also to high β effects) are predicted to result in adequate current drive efficiency, with ~ 400 - 500 kA of noninductive current driven. Sufficient per-pass absorption (>10%) to ensure effective electron heating is also expected for the startup plasma. Present plans call for a single twelve strap antenna driven by six FMIT transmitters operating at 30 MHz. The design for the antenna and matching system will also be discussed.

  7. Assessment of driving-related performance in chronic whiplash using an advanced driving simulator.

    Science.gov (United States)

    Takasaki, Hiroshi; Treleaven, Julia; Johnston, Venerina; Rakotonirainy, Andry; Haines, Andrew; Jull, Gwendolen

    2013-11-01

    Driving is often nominated as problematic by individuals with chronic whiplash associated disorders (WAD), yet driving-related performance has not been evaluated objectively. The purpose of this study was to test driving-related performance in persons with chronic WAD against healthy controls of similar age, gender and driving experience to determine if driving-related performance in the WAD group was sufficiently impaired to recommend fitness to drive assessment. Driving-related performance was assessed using an advanced driving simulator during three driving scenarios; freeway, residential and a central business district (CBD). Total driving duration was approximately 15min. Five driving tasks which could cause a collision (critical events) were included in the scenarios. In addition, the effect of divided attention (identify red dots projected onto side or rear view mirrors) was assessed three times in each scenario. Driving performance was measured using the simulator performance index (SPI) which is calculated from 12 measures. z-Scores for all SPI measures were calculated for each WAD subject based on mean values of the control subjects. The z-scores were then averaged for the WAD group. A z-score of ≤-2 indicated a driving failing grade in the simulator. The number of collisions over the five critical events was compared between the WAD and control groups as was reaction time and missed response ratio in identifying the red dots. Seventeen WAD and 26 control subjects commenced the driving assessment. Demographic data were comparable between the groups. All subjects completed the freeway scenario but four withdrew during the residential and eight during the CBD scenario because of motion sickness. All scenarios were completed by 14 WAD and 17 control subjects. Mean z-scores for the SPI over the three scenarios was statistically lower in the WAD group (-0.3±0.3; P0.05). Assessment of driving in an advanced driving simulator for approximately 15min revealed

  8. Evolving rocket optics applications drive manufacturing advances

    Science.gov (United States)

    Myer, Brian; Perdue, Jamie; Bartlett, Kevin; DeGroote Nelson, Jessica

    2017-10-01

    Improvements to sensing hardware and image processing for airborne optical systems have inspired designers to propose new optics and windows which may be any of: more precise, conformal/freeform and multi-functional. Manufacture of these optics has required innovations in machining, polishing and metrology. The performance requirements and manufacturing methods demand more from conventional optical materials, while also driving development of new formulations with tailored optical and mechanical properties. We describe innovations in manufacturing and adaptations for optical materials selected for end-use performance, though some such materials may present unusual challenges related to their composition, how they are produced, and/or the design geometry. Our desire is to share some observations with the optical designer, who may be able to incorporate some tips into parts "designed for manufacture."

  9. Current drive by Alfven waves in elongated cross section tokamak

    Energy Technology Data Exchange (ETDEWEB)

    Tsypin, V.S.; Elfimov, A.G.; Nekrasov, F.M.; Azevedo, C.A. [Universidade Federal, Rio de Janeiro, RJ (Brazil). Inst. de Fisica; Assis, A.S. de [Universidade Federal Fluminense, Niteroi, RJ (Brazil). Inst. de Fisica

    1997-12-31

    Full text. The problem of the noninductive current drive in cylindrical plasma model and in circular cross-section tokamaks had been already discussed intensively. At the beginning of the study of this problem it have been clear that there are significant difficulties in using of the current-drive in toroidal magnetic traps, especially in a tokamak reactor. Thus, in the case of the lower-hybrid current-drive the efficiency of this current-drive drops strongly as the plasma density increases. For the Alfven waves, there is an opinion that the efficiency of the current-drive drops as a result of waves absorption by the trapped particles 1,2. Okhawa proposed that the current in a magnetized plasma can be maintained also by means of forces, depending on the radiofrequency (rf) field amplitude gradients (the helicity injection). This idea was developed later, some new hopes appeared, connected with the possibility of the current-drive efficiency increasing. It was shown that for the cylindrical plasmas the local efficiency of Alfev wave current drive can be increased by one order of magnitude due to gradient forces, for the kinetic Alfven waves (KAW) and the global Alfven waves (GAW) at some range of the phase velocity. For tokamaks, this additional nonresonant current drive does not depend on the trapped particle effects, which reduce strongly the Alfven current drive efficiency in tokamaks, as it is supposed. Now, the theory development of the Alfven wave (AW) current drive is very important in the cource of the future experiments on the TCA/BR tokamak (Brazil). In this paper, an attempt is made to clarify some general aspects of this problems for magnetic traps. For large aspects ratio tokamaks, with an elongated cross-section, some general formulas concerning the untrapped and trapped particles dynamics and their input to the Landau damping of the Alfven waves, are presented. They are supposed to be used for the further development of the Alfven current drive theory

  10. Advancements, prospects, and impacts of automated driving systems

    Directory of Open Access Journals (Sweden)

    Ching-Yao Chan

    2017-09-01

    Full Text Available Over the last decade, significant progress has been made in automated driving systems (ADS. Given the current momentum and progress, ADS can be expected to continue to advance and a variety of ADS products will become commercially available within a decade. It is envisioned that automated driving technology will lead to a paradigm shift in transportation systems in terms of user experience, mode choices, and business models. In this paper, we start with a review of the state-of-the-art in the field of ADS and their deployment paths. It is followed by a discussion of the future prospects of ADS and their effects on various aspects of the transportation field. We then identify two specific use cases of ADS where the impacts can be significant – personal mobility services and vehicle automation for aging society. A survey of impact assessment studies and the associated methodologies for evaluating ADS is given, which is followed by concluding remarks at the end of the paper.

  11. Treeline advance - driving processes and adverse factors

    Directory of Open Access Journals (Sweden)

    F.-K. Holtmeier

    2007-06-01

    Full Text Available The general trend of climatically-driven treeline advance is modified by regional, local and temporal variations. Treelines will not advance in a closed front parallel to the shift of any isotherm to higher elevations and more northern latitudes. The effects of varying topography on site conditions and the after-effects of historical disturbances by natural and anthropogenic factors may override the effects of slightly higher average temperatures. Moreover, the varying treeline-forming species respond in different ways to a changing climate. Forest advance upwards and northwards primarily depends on successful regeneration and survival of young growth rather than on increasing growth rates of mature trees. Every assessment of treeline response to future climate change must consider the effects of local site conditions and feedbacks of in-creasing tree population in modulating the climatically-driven change. Treeline-shift will influence regional and local climates, pedogenesis, plant communities, animal populations and biodiversity as well as having a considerable effect on economic changes in primary production. A better understanding of the functional relationships between the many treeline-relevant factors and treeline dynamics can be achieved only by extensive research at different scales within different climatic regions supported by as many as possible experimental studies in the field together with laboratory and remote sensing techniques.

  12. Approximate quantitative relationships for rotating magnetic field current drive

    International Nuclear Information System (INIS)

    Hugrass, W.N.; Ohnishi, M.

    1999-01-01

    A simplified model for the rotating magnetic field (RMF) current drive in an infinitely long cylindrical plasma is used to obtain approximate relationships between the fluid flow velocities, collisionality and degree of nonlinearity. These approximate relationships provide simple quantitative estimates for the basic conditions required for the RMF current drive technique to be applied successfully. In particular, the condition required for the motion of the ion fluid not to be flux-preserving, is evaluated quantitatively for the first time. (author)

  13. Oversampled deadbeat current control strategy for PMSM drives

    OpenAIRE

    Rovere, Luca; Formentini, Andrea; Zanchetta, Pericle

    2016-01-01

    This paper presents a novel deadbeat current control approach for Permanent Magnet Synchronous Motors (PMSMs) drives capable of operating at a controller sampling frequency multiple of the power converter switching frequency. The proposed technique permits to achieve a constant switching frequency and an optimal current ripple along with a high current loop bandwidth and robust behaviour to parameter variation.

  14. Current drive experiments at the electron cyclotron frequency

    International Nuclear Information System (INIS)

    Erckmann, V.; Gasparino, U.; Maassberg, H.; Renner, H.; Tutter, M.; Kasparek, W.; Mueller, G.A.; Schueller, P.G.; Thumm, M.

    1991-01-01

    The experimental investigation of non-inductive current drive by electromagnetic waves in the electron cyclotron range of frequencies and the comparison with theoretical predictions attracts increasing interest in both, tokamak as well as stellarator research. In spite of the low current drive efficiency (compared to Lower Hybrid Current Drive) Electron Cyclotron Current Drive (ECCD) is a candidate for MHD-mode control and current profil shaping in tokamaks and stellarators due to the high localization of the driven currents and the capability to drive currents in the plasma centre in large machines. ECCD is an appropriate tool for the control of the pressure effects on the profile of the rotational transform, particularly the bootstrap current in stellarators. This is a crucial condition to maintain good confinement properties in low shear configurations such as W VII-AS. Basic experimental investigations were performed at the W VII-AS stellarator, where the small EC-driven currents are not masked by large inductively driven currents as in tokamaks. The theoretical treatment of ECCD in stellarators would require a Fokker Planck solution in full phase space taking into account the complex magnetic field configuration (trapped particles, loss cone effects) which is untractable. In a first approach, we have compared our experimental data to a simple analytical current drive model (linearized in slab geometry) which is incorporated in a ray-tracing code. In a second step, we have analysed the sensitivity of the model with respect to simplified assumptions on trapped particles and quasi-linear effects. (orig.)

  15. Model for ICRF fast wave current drive in self-consistent MHD equilibria

    International Nuclear Information System (INIS)

    Bonoli, P.T.; Englade, R.C.; Porkolab, M.; Fenstermacher, M.E.

    1993-01-01

    Recently, a model for fast wave current drive in the ion cyclotron radio frequency (ICRF) range was incorporated into the current drive and MHD equilibrium code ACCOME. The ACCOME model combines a free boundary solution of the Grad Shafranov equation with the calculation of driven currents due to neutral beam injection, lower hybrid (LH) waves, bootstrap effects, and ICRF fast waves. The equilibrium and current drive packages iterate between each other to obtain an MHD equilibrium which is consistent with the profiles of driven current density. The ICRF current drive package combines a toroidal full-wave code (FISIC) with a parameterization of the current drive efficiency obtained from an adjoint solution of the Fokker Planck equation. The electron absorption calculation in the full-wave code properly accounts for the combined effects of electron Landau damping (ELD) and transit time magnetic pumping (TTMP), assuming a Maxwellian (or bi-Maxwellian) electron distribution function. Furthermore, the current drive efficiency includes the effects of particle trapping, momentum conserving corrections to the background Fokker Planck collision operator, and toroidally induced variations in the parallel wavenumbers of the injected ICRF waves. This model has been used to carry out detailed studies of advanced physics scenarios in the proposed Tokamak Physics Experiment (TPX). Results are shown, for example, which demonstrate the possibility of achieving stable equilibria at high beta and high bootstrap current fraction in TPX. Model results are also shown for the proposed ITER device

  16. RF current drive: common fallacies in simple theory

    International Nuclear Information System (INIS)

    Canobbio, E.; Croci, R.

    1982-01-01

    Two RF current drive models are briefly re-examined: 1) current drive parallel to B-vector 0 as given by the 1 D quasi-linear Fokker-Planck equation. It is shown that the predicted j and P values do not tend to the correct linearized 2 D values when the RF field amplitude is small, although the ratio j/P is essentially correct; 2) current drive perpendicular to B-vector 0 by means of rotating magnetic fields (the Blevin-Thonemann mechanism). The RF field configuration considered so far is found to be incomplete. As a result stable current generation not only occurs under different conditions but also requires much less power than recently estimated. (author)

  17. Fast wave current drive in DIII-D

    International Nuclear Information System (INIS)

    Petty, C.C.; Callis, R.W.; Chiu, S.C.; deGrassie, J.S.; Forest, C.B.; Freeman, R.L.; Gohil, P.; Harvey, R.W.; Ikezi, H.; Lin-Liu, Y.-R.

    1995-02-01

    The non-inductive current drive from fast Alfven waves launched by a directional four-element antenna was measured in the DIII-D tokamak. The fast wave frequency (60 MHz) was eight times the deuterium cyclotron frequency at the plasma center. An array of rf pickup loops at several locations around the torus was used to verify the directivity of the four-element antenna. Complete non-inductive current drive was achieved using a combination of fast wave current drive (FWCD) and electron cyclotron current drive (ECCD) in discharges for which the total plasma current was inductively ramped down from 400 to 170 kA. For discharges with steady plasma current, up to 110 kA of FWCD was inferred from an analysis of the loop voltage, with a maximum non-inductive current (FWCD, ECCD, and bootstrap) of 195 out of 310 kA. The FWCD efficiency increased linearly with central electron temperature. For low current discharges, the FWCD efficiency was degraded due to incomplete fast wave damping. The experimental FWCD was found to agree with predictions from the CURRAY ray-tracing code only when a parasitic loss of 4% per pass was included in the modeling along with multiple pass damping

  18. Joint Czechoslovak-Soviet workshop on current drive in tokamaks

    International Nuclear Information System (INIS)

    1985-10-01

    At the Joint Czechoslovak-Soviet Workshop on Current Drive in Tokamaks, five papers dealing with issues of general interest were presented. In a theoretical paper by Klima and Pavlo a one-dimensional model of the lower-hybrid current drive is described and the results of its analysis are used in a numerical simulation using T-7 tokamak parameters. In the second theoretical paper by Vojtsekhovich, Parail and Pereverzev the influence of the LH wave spectrum on the efficiency of the current drive is studied. Two papers deal with a new microwave system designed for experiments on LHCD in the T-7 tokamak. In particular, the power spectra of new four-waveguide grills are computed. In the last paper the non-inductive start-up of the discharge in the T-7 tokamak by means of electron cyclotron waves is investigated. (J.U.)

  19. Electron-cyclotron resonance heating and current drive

    International Nuclear Information System (INIS)

    Filone, I.

    1992-01-01

    A brief summary of the theory and experiments on electron-cyclotron heating and current drive is presented. the general relativistic formulation of wave propagation and linear absorption is considered in some detail. The O-mode and the X-mode for normal and oblique propagation are investigated and illustrated by several examples. The experimental verification of the theory in T-10 and D-III-D is briefly discussed. Quasilinear evolution of the momentum distribution and related applications as, for instance, non linear wave damping and current drive, are also considered for special cases of wave frequencies, polarization and propagation. In the concluding section we present the general formulation of the wave damping and current drive in the absence of electron trapping for arbitrary values of the wave frequency. (author) 8 fig. 13 ref

  20. High-current cyclotron to drive an electronuclear assembly

    CERN Document Server

    Alenitsky, Yu G

    2002-01-01

    The proposal on creation of a high-current cyclotron complex for driving an electronuclear assembly reported at the 17th Meeting on Accelerators of Charged Particles is discussed. Some changes in the basic design parameters of the accelerator are considered in view of new results obtained in the recent works. It is shown that the cyclotron complex is now the most real and cheapest accelerator for production of proton beams with a power of up to 10 MW. Projects on design of a high-current cyclotron complex for driving an electronuclear subcritical assembly are presented.

  1. ELECTRON CYCLOTRON CURRENT DRIVE EFFICIENCY IN GENERAL TOKAMAK GEOMETRY

    International Nuclear Information System (INIS)

    LIN-LUI, Y.R; CHAN, V.S; PRATER, R.

    2003-01-01

    Green's-function techniques are used to calculate electron cyclotron current drive (ECCD) efficiency in general tokamak geometry in the low-collisionality regime. Fully relativistic electron dynamics is employed in the theoretical formulation. The high-velocity collision model is used to model Coulomb collisions and a simplified quasi-linear rf diffusion operator describes wave-particle interactions. The approximate analytic solutions which are benchmarked with a widely used ECCD model, facilitate time-dependent simulations of tokamak operational scenarios using the non-inductive current drive of electron cyclotron waves

  2. Steady-state current drive by lower hybrid waves

    International Nuclear Information System (INIS)

    Belyanskaya, N.V.; Dnestrovskii, Y.N.; Kostomarov, D.P.; Smirnov, A.P.

    1986-01-01

    Steady-state current drive in a plasma by lower-hybrid waves with a square-wave spectrum is analyzed in the linear approximation. A linearized two-dimensional kinetic equation in velocity space for the electron distribution function is reduced to a one-dimensional expansion in Legendre polynomials. A numerical solution is found for the complete equation, and an analytic solution is found for the asymptotic equation. The results can be used to determine the effect of the spectral width of the excited waves on the efficiency of the current drive. The analytic solution agrees well with the numerical solution

  3. Numerical analysis on the synergy between electron cyclotron current drive and lower hybrid current drive in tokamak plasmas

    International Nuclear Information System (INIS)

    Chen, S Y; Hong, B B; Liu, Y; Lu, W; Huang, J; Tang, C J; Ding, X T; Zhang, X J; Hu, Y J

    2012-01-01

    The synergy between electron cyclotron current drive (ECCD) and lower hybrid current drive (LHCD) is investigated numerically with the parameters of the HL-2A tokamak. Based on the understanding of the synergy mechanisms, a high current driven efficiency or a desired radial current profile can be achieved through properly matching the parameters of ECCD and LHCD due to the flexibility of ECCD. Meanwhile, it is found that the total current driven by the electron cyclotron wave (ECW) and the lower hybrid wave (LHW) simultaneously can be smaller than the sum of the currents driven by the ECW and LHW separately, when the power of the ECW is much larger than the LHW power. One of the reasons leading to this phenomenon (referred to as negative synergy in this context) is that fast current-carrying electrons tend to be trapped, when the perpendicular velocity driven by the ECW is large and the parallel velocity decided by the LHW is correspondingly small. (paper)

  4. Current advances in seismic technology

    International Nuclear Information System (INIS)

    Sherwood, J.R.

    1996-01-01

    Recent advances in seismic technology that impact on the estimation of reserves and reduction in risks associated with reserves estimates, were discussed. It was noted that seismic data along with subsurface geological and engineering data is a powerful tool that has applications to interpret the petroleum system and the reserves associated with that system. For example, seismic data can be used to define the location of reserves and to show results of drilling activity. Other reserve parameters that can be estimated using seismic tools are: area, thickness, porosity, saturation, recovery factor, and formation volume factor. Two case histories where seismic techniques were used for reserves estimation were described

  5. Numerical modeling of lower hybrid heating and current drive

    Energy Technology Data Exchange (ETDEWEB)

    Valeo, E.J.; Eder, D.C.

    1986-03-01

    The generation of currents in toroidal plasma by application of waves in the lower hybrid frequency range involves the interplay of several physical phenomena which include: wave propagation in toroidal geometry, absorption via wave-particle resonances, the quasilinear generation of strongly nonequilibrium electron and ion distribution functions, and the self-consistent evolution of the current density in such a nonequilibrium plasma. We describe a code, LHMOD, which we have developed to treat these aspects of current drive and heating in tokamaks. We present results obtained by applying the code to a computation of current ramp-up and to an investigation of the possible importance of minority hydrogen absorption in a deuterium plasma as the ''density limit'' to current drive is approached.

  6. On Ion Cyclotron Current Drive for sawtooth control

    International Nuclear Information System (INIS)

    Eriksson, L.-G.; Johnson, T.; Hellsten, T.; Mayoral, M.-L.; McDonald, D.; Santala, M.; Vries, P. de; Coda, S.; Sauter, O.; Mueck, A.; Buttery, R.J.; Mantsinen, M.J.; Noterdaeme, J.-M.; Westerhof, E.

    2006-01-01

    Experiments using Ion Cyclotron Current Drive (ICCD) to control sawteeth are presented. In particular, discharges demonstrating shortening of fast ion induced long sawteeth reported in [L.-G. Eriksson et al., Physical Review Letters 92, 235004 (2004)] by ICCD have been analysed in detail. Numerical simulations of the ICCD driven currents are shown to be consistent with the experimental observations. They support the hypothesis that an increase of the magnetic shear, due to the driven current, at the surface where the safety factor is unity was the critical factor for the shortening of the sawteeth. In view of the potential utility of ICCD, the mechanisms for the current drive have been further investigated experimentally. This includes the influence of the averaged energy of the resonating ions carrying the current and the spectrum of the launched waves. The results of these experiments are discussed in the light of theoretical considerations. (author)

  7. Numerical modeling of lower hybrid heating and current drive

    International Nuclear Information System (INIS)

    Valeo, E.J.; Eder, D.C.

    1986-03-01

    The generation of currents in toroidal plasma by application of waves in the lower hybrid frequency range involves the interplay of several physical phenomena which include: wave propagation in toroidal geometry, absorption via wave-particle resonances, the quasilinear generation of strongly nonequilibrium electron and ion distribution functions, and the self-consistent evolution of the current density in such a nonequilibrium plasma. We describe a code, LHMOD, which we have developed to treat these aspects of current drive and heating in tokamaks. We present results obtained by applying the code to a computation of current ramp-up and to an investigation of the possible importance of minority hydrogen absorption in a deuterium plasma as the ''density limit'' to current drive is approached

  8. Hamiltonian analysis of fast wave current drive in tokamak plasmas

    International Nuclear Information System (INIS)

    Becoulet, A.; Fraboulet, D.; Giruzzi, G.; Moreau, D.; Saoutic, B.

    1993-12-01

    The Hamiltonian formalism is used to analyze the direct resonant interaction between the fast magnetosonic wave and the electrons in a tokamak plasma. The intrinsic stochasticity of the electron phase space trajectories is derived, and together with extrinsic de-correlation processes, assesses the validity of the quasilinear approximation for the kinetic studies of fast wave current drive (FWCD). A full-wave resolution of the Maxwell-Vlasov set of equations provides the exact pattern of the wave fields in a complete tokamak geometry, for a realistic antenna spectrum. The local quasilinear diffusion tensor is derived from the wave fields, and is used for a computation of the driven current and deposited power profiles, the current drive efficiency, including possible non-linear effects in the kinetic equation. Several applications of FWCD on existing and future machines are given, as well as results concerning combination of FWCD with other non inductive current drive methods. An analytical expression for the current drive efficiency is given in the high single-pass absorption regimes. (authors). 20 figs., 1 tab., 26 refs

  9. Research on Predicting Drive Current of Shipborne Satcom Antenna

    Directory of Open Access Journals (Sweden)

    Kong Jinping

    2015-01-01

    Full Text Available Predicting the effect of antenna wind load on servo system precisely is meaningful to ensure the safety of satcom antenna on operation, which can avoid overload operation. In this paper, the computational fluid dynamics is used to proceed numerical computation on the pressure distribution of the reflector and torque of drive shaft under different wind speed, windward angle and angle of pitch of the antenna. The simulation model is built under MATLAB/Simulink simulation environment, and the drive current of the antenna servo system is analyzed under wind load effect and ship swing. Then, a method of predicting drive current of antenna servo system according to the wind speed, wind direction and attitude of the antenna is concluded. And this method is verified by simulation at last.

  10. Lower-hybrid heating and current drive on PLT

    International Nuclear Information System (INIS)

    Hooke, W.; Bernabei, S.; Boyd, D.

    1983-02-01

    Steady currents up to 165 kA for 3.5 seconds and 420 kA for 0.3 seconds have been maintained by 800 MHz lower hybrid waves. For line-averaged densities up to 7 x 10 12 cm - 3 the current is maintained with no input power from the ohmic heating transformer. The waves are launched with an array of six waveguides. Measurements of X rays and electron cyclotron radiation show that the rf power produces and maintains a suprathermal tail of electrons apparently independent of the number of fast electrons in the plasma prior to turning on the rf power. Measurements of current-drive efficiency and the electron tail provide direct evidence for a resonant wave-particle interaction. The radial profile of the rf-sustained current inferred from x-ray measurements is peaked in the center of the plasma and appears to obey the same q-value restraints as the inductively driven ohmic heating current. Current drive is observed to be accompanied always by radiation at frequencies greater than or equal to #betta#/sub ce/ and less than or equal to #betta#/sub pe/. The connection between this radiation and the current-drive mechanism is under study

  11. Langmuir probe study in the nonresonant current drive regime of ...

    Indian Academy of Sciences (India)

    Abstract. Characterization of the current drive regime is done for helicon wave- generated plasma in a torus, at a very high operating frequency. A radiofrequency- compensated Langmuir probe is designed and used for the measurement of plasma parameters along with the electron energy distributions in radial scans of the ...

  12. Current advances in liver surgery

    Directory of Open Access Journals (Sweden)

    Shannon Melissa Chan

    2015-01-01

    Full Text Available Hepatobiliary surgery has taken a big step forward in recent decades especially in the minimally invasive approach for hepatectomy. From being sceptical at the beginning of the 1990s when laparoscopic surgery had become prevalent, to now, where laparoscopic hepatectomy has been well-established, especially in minor hepatectomies; this new technique has evolved rapidly over the past 20-years demonstrating better short-term outcomes and equivalent oncological outcomes in selected patients and in expert hands. Laparoscopic hepatectomy is indeed, more difficult to master than the open procedure with restrictions in working space, difficulty in haemostasis and the potential risk of gas embolism. However, with better visibility of the operative field around the liver, especially beneath the costal margin, the magnified view and theoretical advantage of pneumoperitoneum acting as haemostatic pressure have made laparoscopic hepatectomy increasingly popular. Another important advancement is the new surgical technique of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS. This procedure induces more rapid liver hypertrophy within a median period of 9-days, allowing resection to be performed in candidates with borderline functional liver remnant and at an earlier date. However, studies have shown that ALPPS is associated with a relatively higher rate of morbidity and mortality. Therefore, it remains a highly controversial treatment option and more studies have to be performed to establish its usefulness and define its role in liver surgery.

  13. Analysis of fast wave current drive from the Alcyon code

    International Nuclear Information System (INIS)

    Becoulet, A.; Moreau, D.; Giruzzi, G.; Saoutic, B.

    1991-01-01

    Fast Wave Current Drive simulations have been performed with the 2-D full wave code ALCYON. These simulations include the computation of the RF field in a Tokamak geometry, for a given launched power spectrum, a linear estimation of the driven current profile using this RF field, and the numerical derivation of the quasilinear diffusion operator for a complete Fokker-Planck calculation. Results concerning the ITER, and the DIII-D Tokamaks are presented and discussed

  14. Fast wave current drive in reactor scale tokamak plasmas

    International Nuclear Information System (INIS)

    Becoulet, A.; Moreau, D.; Saoutic, B.

    1991-01-01

    The possibility for driving current in large tokamak plasmas using the fast magnetosonic wave is analysed in terms of linear propagation-absorption, and also in terms of quasilinear absorption through an hamiltonian analysis of the wave-particle interaction. The tokamak geometry is shown to strongly influence the capability for the fast wave to sustain a significant part of the toroidal current. Synergetic effects with other scenarios are also discussed

  15. AMCP Partnership Forum: Driving New Advances in Dyslipidemia Management.

    Science.gov (United States)

    2016-04-01

    Proprotein convertase subtilisin kexin 9 (PCSK9) inhibitors are specialty medications approved for the treatment of dyslipidemia. Because dyslipidemia is a prevalent and chronic condition, the costs associated with PCSK9 inhibitors must be carefully weighed against the benefits that they provide. However, the long-term clinical benefits of these agents are not yet fully defined, creating a complex situation for third-party payers who must determine how to allocate limited resources. To engage national stakeholders in a discussion of how to wisely use PCSK9 inhibitors in health care, the Academy of Managed Care Pharmacy organized a forum in Washington, DC, on September 16, 2015. The forum began with presentations reviewing the current environment for dyslipidemia treatment. Following these presentations, participants engaged in discussions regarding how to best select patients for treatment based on current treatment guidelines, how managed care pharmacy can best manage high-cost specialty products that may be indicated for large numbers of patients, and how managed care organizations can use real-world evidence to assess the impact of evolving treatment guidelines and options. Participants called for the development of a national database to gather more meaningful data regarding the impact of PCSK9 inhibitors on clinical outcomes. Such a database would be invaluable for determining the real-world impact of specialty medications and would support the development of sensible third-party payer benefit structures, coverage decisions, medical policies, and risk-sharing contracts. In the meantime, participants recommended enhanced collaboration among stakeholders for improved information sharing, increased collection and evaluation of real-world evidence, use of available cost-effectiveness analyses, and the implementation of strategies that optimize the use of evidence-based therapies. The AMCP Partnership Forum on Driving New Advances in Dyslipidemia Management and the

  16. Enhanced lower hybrid current drive experiments on HT-7 tokamak

    International Nuclear Information System (INIS)

    Shen Weici; Kuang Guangli; Liu Yuexiu; Ding Bojiang; Shi Yaojiang

    2003-01-01

    Effective Lower Hybrid Current Driving (LHCD) and improved confinement experiments in higher plasma parameters (I p >200 kA, n e >2 x 10 13 cm -3 , T e ≥1 keV) have been curried out in optimized LH wave spectrum and plasma parameters in HT-7 superconducting tokamak. The dependence of current driving efficiency on LH power spectrum, plasma density (anti n e ) and toroidal magnetic field B T has been obtained under optimal conditions. A good CD efficiency was obtained at higher plasma current and higher electron density. The improvement of the energy confinement time is accompanied with the increase in line averaged electron density, and in ion and electron temperatures. The highest current driving efficiency reached η CD =I p (anti n e )R/P RF ≅1.05 x 10 19 Am -2 /W. Wave-plasma coupling was sustained in a good state and the reflective coefficient was less than 5%. The experiments have also demonstrated the ability of LH wave in the start-up and ramp-up of the plasma current. The measurement of the temporal distribution of plasma parameter shows that lower hybrid leads to a broader profile in plasma parameter. The LH power deposition profile and the plasma current density profile were modeled with a 2D Fokker-Planck code corresponding to the evolution process of the hard x-ray detector array

  17. Electric machine and current source inverter drive system

    Science.gov (United States)

    Hsu, John S

    2014-06-24

    A drive system includes an electric machine and a current source inverter (CSI). This integration of an electric machine and an inverter uses the machine's field excitation coil for not only flux generation in the machine but also for the CSI inductor. This integration of the two technologies, namely the U machine motor and the CSI, opens a new chapter for the component function integration instead of the traditional integration by simply placing separate machine and inverter components in the same housing. Elimination of the CSI inductor adds to the CSI volumetric reduction of the capacitors and the elimination of PMs for the motor further improve the drive system cost, weight, and volume.

  18. Physics of electron cyclotron current drive on DIII-D

    CERN Document Server

    Petty, C C; Harvey, R W; Kinsey, J E; Lao, L L; Lohr, J; Luce, T C; Makowski, M A; Prater, R

    2002-01-01

    OAK A271 PHYSICS OF ELECTRON CYCLOTRON CURRENT DRIVE ON DIII-D. Recent experiments on the DIII-D tokamak have focused on determining the effect of trapped particles on the electron cyclotron current drive (ECCD) efficiency. The measured ECCD efficiency increases as the deposition location is moved towards the inboard midplane or towards smaller minor radius for both co and counter injection. The measured ECCD efficiency also increases with increasing electron density and/or temperature. The experimental ECCD is compared to both the linear theory (Toray-GA) as well as a quasilinear Fokker-Planck model (CQL3D). The experimental ECCD is found to be in better agreement with the more complete Fokker-Planck calculation, especially for cases of high rf power density and/or loop voltage. The narrow width of the measured ECCD profile is consistent with only low levels of radial transport for the current carrying electrons.

  19. Current-Drive Efficiency in a Degenerate Plasma

    Energy Technology Data Exchange (ETDEWEB)

    S. Son and N.J. Fisch

    2005-11-01

    a degenerate plasma, the rates of electron processes are much smaller than the classical model would predict, affecting the efficiencies of current generation by external non-inductive means, such as by electromagnetic radiation or intense ion beams. For electron-based mechanisms, the current-drive efficiency is higher than the classical prediction by more than a factor of 6 in a degenerate hydrogen plasma, mainly because the electron-electron collisions do not quickly slow down fast electrons. Moreover, electrons much faster than thermal speeds are more readily excited without exciting thermal electrons. In ion-based mechanisms of current drive, the efficiency is likewise enhanced due to the degeneracy effects, since the electron stopping power on slow ion beams is significantly reduced.

  20. Current advances in orthodontic pain.

    Science.gov (United States)

    Long, Hu; Wang, Yan; Jian, Fan; Liao, Li-Na; Yang, Xin; Lai, Wen-Li

    2016-06-30

    Orthodontic pain is an inflammatory pain that is initiated by orthodontic force-induced vascular occlusion followed by a cascade of inflammatory responses, including vascular changes, the recruitment of inflammatory and immune cells, and the release of neurogenic and pro-inflammatory mediators. Ultimately, endogenous analgesic mechanisms check the inflammatory response and the sensation of pain subsides. The orthodontic pain signal, once received by periodontal sensory endings, reaches the sensory cortex for pain perception through three-order neurons: the trigeminal neuron at the trigeminal ganglia, the trigeminal nucleus caudalis at the medulla oblongata and the ventroposterior nucleus at the thalamus. Many brain areas participate in the emotion, cognition and memory of orthodontic pain, including the insular cortex, amygdala, hippocampus, locus coeruleus and hypothalamus. A built-in analgesic neural pathway-periaqueductal grey and dorsal raphe-has an important role in alleviating orthodontic pain. Currently, several treatment modalities have been applied for the relief of orthodontic pain, including pharmacological, mechanical and behavioural approaches and low-level laser therapy. The effectiveness of nonsteroidal anti-inflammatory drugs for pain relief has been validated, but its effects on tooth movement are controversial. However, more studies are needed to verify the effectiveness of other modalities. Furthermore, gene therapy is a novel, viable and promising modality for alleviating orthodontic pain in the future.

  1. Dynamic modelling of tearing mode stabilization by RF current drive

    International Nuclear Information System (INIS)

    Giruzzi, G.; Zabiego, M.; Gianakon, T.A.; Garbet, X.; Bernabei, S.

    1998-01-01

    The theory of tearing mode stabilization in toroidal plasmas by RF-driven currents that are modulated in phase with the island rotation is investigated. A time scale analysis of the phenomena involved indicates that transient effects, such as finite time response of the driven currents, island rotation during the power pulses, and the inductive response of the plasma, are intrinsically important. A dynamic model of such effects is developed, based on a 3-D Fokker-Planck code coupled to both the electric field diffusion and the island evolution equations. Extensive applications to both Electron Cyclotron and Lower Hybrid current drive in ITER are presented. (author)

  2. Direct calculation of current drive efficiency in FISIC code

    International Nuclear Information System (INIS)

    Wright, J.C.; Phillips, C.K.; Bonoli, P.T.

    1996-01-01

    Two-dimensional RF modeling codes use a parameterization (1) of current drive efficiencies to calculate fast wave driven currents. This parameterization assumes a uniform quasi-linear diffusion coefficient and requires a priori knowledge of the wave polarizations. These difficulties may be avoided by a direct calculation of the quasilinear diffusion coefficient from the Kennel-Englemann form with the field polarizations calculated by the full wave code, FISIC (2). Current profiles are calculated using the adjoint formulation (3). Comparisons between the two formulations are presented. copyright 1996 American Institute of Physics

  3. Direct calculation of current drive efficiency in FISIC code

    Science.gov (United States)

    Wright, J. C.; Phillips, C. K.; Bonoli, P. T.

    1996-02-01

    Two-dimensional RF modeling codes use a parameterization (1) of current drive efficiencies to calculate fast wave driven currents. This parameterization assumes a uniform quasi-linear diffusion coefficient and requires a priori knowledge of the wave polarizations. These difficulties may be avoided by a direct calculation of the quasilinear diffusion coefficient from the Kennel-Englemann form with the field polarizations calculated by the full wave code, FISIC (2). Current profiles are calculated using the adjoint formulation (3). Comparisons between the two formulations are presented.

  4. Direct calculation of current drive efficiency in FISIC code

    Energy Technology Data Exchange (ETDEWEB)

    Wright, J.C.; Phillips, C.K. [Plasma Physics Laboratory, Princeton University, Princeton, New Jersey 08543-0451 (United States); Bonoli, P.T. [Plasma Fusion Center, MIT Cambridge, Massachusetts 02139 (United States)

    1996-02-01

    Two-dimensional RF modeling codes use a parameterization (1) of current drive efficiencies to calculate fast wave driven currents. This parameterization assumes a uniform quasi-linear diffusion coefficient and requires {ital a} {ital priori} knowledge of the wave polarizations. These difficulties may be avoided by a direct calculation of the quasilinear diffusion coefficient from the Kennel-Englemann form with the field polarizations calculated by the full wave code, FISIC (2). Current profiles are calculated using the adjoint formulation (3). Comparisons between the two formulations are presented. {copyright} {ital 1996 American Institute of Physics.}

  5. RF heating and current drive in Tore Supra

    International Nuclear Information System (INIS)

    Litaudon, X.

    1995-01-01

    Recent RF heating and current drive experiments in the Lower Hybrid (LH) and Ion Cyclotron (IC) frequency ranges are reported. In the 4T improved confinement LHEP regime, steady-state LHCD operation has been realized with a new ''constant-flux'' scenario. A new, reversed shear, 2T improved confinement plasma regime has also been investigated when the core plasma is inaccessible to the LH waves. Stable, LH driven 0.4 MA discharges were obtained with H rlw = 2 at βp = 0.8, q o above 2 and with a reduced electron thermal diffusivity in the central reversed shear region. Efficient direct coupling of the fast magnetosonic wave to the electrons for heating and current drive is observed during 48 MHz/2T operation. Fast wave electron heating has produced improved confinement with H rlw = 2 at βp = 1.6, and a bootstrap current fraction up to 45%. Fast wave current drive has been observed at the level of 80 kA in a 0.4 MA discharge. (authors). 28 refs., 7 figs

  6. Hot spots and dark current in advanced plasma wakefield accelerators

    Directory of Open Access Journals (Sweden)

    G. G. Manahan

    2016-01-01

    Full Text Available Dark current can spoil witness bunch beam quality and acceleration efficiency in particle beam-driven plasma wakefield accelerators. In advanced schemes, hot spots generated by the drive beam or the wakefield can release electrons from higher ionization threshold levels in the plasma media. These electrons may be trapped inside the plasma wake and will then accumulate dark current, which is generally detrimental for a clear and unspoiled plasma acceleration process. Strategies for generating clean and robust, dark current free plasma wake cavities are devised and analyzed, and crucial aspects for experimental realization of such optimized scenarios are discussed.

  7. Optimized calculation of the synergy conditions between electron cyclotron current drive and lower hybrid current drive on EAST

    International Nuclear Information System (INIS)

    Wei Wei; Ding Bo-Jiang; Li Miao-Hui; Zhang Xin-Jun; Wang Xiao-Jie; Peysson, Y; Decker, J; Zhang Lei

    2016-01-01

    The optimized synergy conditions between electron cyclotron current drive (ECCD) and lower hybrid current drive (LHCD) with normal parameters of the EAST tokamak are studied by using the C3PO/LUKE code based on the understanding of the synergy mechanisms so as to obtain a higher synergistic current and provide theoretical reference for the synergistic effect in the EAST experiment. The dependences of the synergistic effect on the parameters of two waves (lower hybrid wave (LHW) and electron cyclotron wave (ECW)), including the radial position of the power deposition, the power value of the LH and EC waves, and the parallel refractive indices of the LHW (N ∥ ) are presented and discussed. (paper)

  8. PHYSICS OF ELECTRON CYCLOTRON CURRENT DRIVE ON DIII-D

    International Nuclear Information System (INIS)

    PETTY, C.C.; PRATER, R.; LUCE, T.C.; ELLIS, R.A.; HARVEY, R.W.; KINSEY, J.E.; LAO, L.L.; LOHR, J.; MAKOWSKI, M.A.

    2002-01-01

    OAK A271 PHYSICS OF ELECTRON CYCLOTRON CURRENT DRIVE ON DIII-D. Recent experiments on the DIII-D tokamak have focused on determining the effect of trapped particles on the electron cyclotron current drive (ECCD) efficiency. The measured ECCD efficiency increases as the deposition location is moved towards the inboard midplane or towards smaller minor radius for both co and counter injection. The measured ECCD efficiency also increases with increasing electron density and/or temperature. The experimental ECCD is compared to both the linear theory (Toray-GA) as well as a quasilinear Fokker-Planck model (CQL3D). The experimental ECCD is found to be in better agreement with the more complete Fokker-Planck calculation, especially for cases of high rf power density and/or loop voltage

  9. Survey of heating and current drive for K-DEMO

    Science.gov (United States)

    Mikkelsen, D. R.; Kessel, C. E.; Poli, F. M.; Bertelli, N.; Kim, K.

    2018-03-01

    We present calculations of heating and current drive by neutral injection and by electromagnetic waves in the ion cyclotron, helicon, lower hybrid, and electron cyclotron frequency ranges for the steady state burn conditions in a K-DEMO configuration with I_p=12.3 MA, a  =  2.1 m, R_o=6.8 m, B_o=7.4 T, \

  10. Electron cyclotron current drive experiments on DIII-D

    Energy Technology Data Exchange (ETDEWEB)

    James, R.A. (Lawrence Livermore National Lab., CA (USA)); Giruzzi, G.; Gentile, B. de; Rodriguez, L. (Association Euratom-CEA, Centre d' Etudes Nucleaires de Cadarache, 13 - Saint-Paul-les-Durance (France)); Fyaretdinov, A.; Gorelov, Yu.; Trukhin, V. (Kurchatov Inst. of Atomic Energy, Moscow (USSR)); Harvey, R.; Lohr, J.; Luce, T.C.; Matsuda, K.; Politzer, P.; Prater, R.; Snider, R. (General Atomics, San Di

    1990-05-01

    Electron Cyclotron Current Drive (ECCD) experiments on the DIII-D tokamak have been performed using 60 GHz waves launched from the high field side of the torus. Preliminary analysis indicates rf driven currents between 50 and 100 kA in discharges with total plasma currents between 200 and 500 kA. These are the first ECCD experiments with strong first pass absorption, localized deposition of the rf power, and {tau}{sub E} much longer than the slowing-down time of the rf generated current carriers. The experimentally measured profiles for T{sub e}, {eta}{sub e} and Z{sub eff} are used as input for a 1D transport code and a multiply-ray, 3D ray tracing code. Comparisons with theory and assessment of the influence of the residual electric field, using a Fokker-Planck code, are in progress. The ECH power levels were between 1 and 1.5 MW with pulse lengths of about 500 msec. ECCD experiments worldwide are motivated by issues relating to the physics and technical advantages of the use of high frequency rf waves to drive localized currents. ECCD is accomplished by preferentially heating electrons moving in one toroidal direction, reducing their collisionality and thereby producing a non-inductively driven toroidal current. 6 refs., 4 figs.

  11. Towards fully non-inductive current drive operation in JET

    International Nuclear Information System (INIS)

    Litaudon, X.; Crisanti, F.; Alper, B.

    2002-01-01

    Quasi steady operation has been achieved at JET in the high confinement regime with Internal Transport Barriers, ITBs. The ITBs' performances are maintained up to 11 s. This duration, much larger than the energy confinement time, is already approaching a current resistive time. The high performance phase is limited only by plant constraints. The radial profiles of the thermal electron and ion pressures have steep gradients typically at mid-plasma radius. A large fraction of non-inductive current (above 80%) is sustained throughout the high performance phase with a poloidal beta exceeding unity. The safety factor profile plays an important role in sustaining the ITB characteristics. In this regime where the self-generated bootstrap current (up to LOMA) represents 50% of the total current, the resistive evolution of the non-monotonic q-profile is slowed down by using off-axis lower hybrid current drive. (authors)

  12. Towards fully non-inductive current drive operation in JET

    Energy Technology Data Exchange (ETDEWEB)

    Litaudon, X. [Association Euratom-CEA Cadarache, Dept. de Recherches sur la Fusion Controlee, 13 - Saint-Paul-lez-Durance (France); Crisanti, F. [Association Euratom-ENEA sulla Fusione, Centro Ricerche Frascati (Italy); Alper, B. [Euratom-UKAEA Fusion Association, Culham Science Centre, Abingdon, Oxon (United Kingdom)] [and others

    2002-01-01

    Quasi steady operation has been achieved at JET in the high confinement regime with Internal Transport Barriers, ITBs. The ITBs' performances are maintained up to 11 s. This duration, much larger than the energy confinement time, is already approaching a current resistive time. The high performance phase is limited only by plant constraints. The radial profiles of the thermal electron and ion pressures have steep gradients typically at mid-plasma radius. A large fraction of non-inductive current (above 80%) is sustained throughout the high performance phase with a poloidal beta exceeding unity. The safety factor profile plays an important role in sustaining the ITB characteristics. In this regime where the self-generated bootstrap current (up to LOMA) represents 50% of the total current, the resistive evolution of the non-monotonic q-profile is slowed down by using off-axis lower hybrid current drive. (authors)

  13. Direct Calculations of Current Drive with a Full Wave Code

    Science.gov (United States)

    Wright, John C.; Phillips, Cynthia K.

    1997-11-01

    We have developed a current drive package that evaluates the current driven by fast magnetosonic waves in arbitrary flux geometry. An expression for the quasilinear flux has been derived which accounts for coupling between modes in the spectrum of waves launched from the antenna. The field amplitudes are calculated in the full wave code, FISIC, and the current response function, \\chi, also known as the Spitzer function, is determined with Charles Karney's Fokker-Planck code, adj.f. Both codes have been modified to incorporate the same numerical equilibria. To model the effects of a trapped particle population, the bounce averaged equations for current and power are used, and the bounce averaged flux is calculated. The computer model is benchmarked against the homogenous equations for a high aspect ratio case in which the expected agreement is confirmed. Results from cases for TFTR, NSTX and CDX-U are contrasted with the predictions of the Ehst-Karney parameterization of current drive for circular equilibria. For theoretical background, please see the authors' archive of papers. (http://w3.pppl.gov/ ~jwright/Publications)

  14. FreedomCAR Advanced Traction Drive Motor Development Phase I

    Energy Technology Data Exchange (ETDEWEB)

    Ley, Josh (UQM Technologies, Inc.); Lutz, Jon (UQM Technologies, Inc.)

    2006-09-01

    The overall objective of this program is to design and develop an advanced traction motor that will meet the FreedomCAR and Vehicle Technologies (FCVT) 2010 goals and the traction motor technical targets. The motor specifications are given in Section 1.3. Other goals of the program include providing a cost study to ensure the motor can be developed within the cost targets needed for the automotive industry. The program has focused on using materials that are both high performance and low costs such that the performance can be met and cost targets are achieved. In addition, the motor technologies and machine design features must be compatible with high volume manufacturing and able to provide high reliability, efficiency, and ruggedness while simultaneously reducing weight and volume. Weight and volume reduction will become a major factor in reducing cost, material cost being the most significant part of manufacturing cost at high volume. Many motor technology categories have been considered in the past and present for traction drive applications, including: brushed direct current (DC), PM (PM) brushless dc (BLDC), alternating current (AC) induction, switched reluctance and synchronous reluctance machines. Of these machine technologies, PM BLDC has consistently demonstrated an advantage in terms of power density and efficiency. As rare earth magnet cost has declined, total cost may also be reduced over the other technologies. Of the many different configurations of PM BLDC machines, those which incorporate power production utilizing both magnetic torque as well as reluctance torque appear to have the most promise for traction applications. There are many different PM BLDC machine configurations which employ both of these torque producing mechanisms; however, most would fall into one of two categories--some use weaker magnets and rely more heavily on reluctance torque (reluctance-dominant PM machines), others use strong PMs and supplement with reluctance torque

  15. Electron cyclotron current drive in the Wendelstein 7-AS stellarator

    International Nuclear Information System (INIS)

    Maassberg, H; Rome, M; Erckmann, V; Geiger, J; Laqua, H P; Marushchenko, N B

    2005-01-01

    High power electron cyclotron current drive (ECCD) experiments in the W7-AS stellarator are analysed. In these net-current-free discharges, the ECCD and the bootstrap current are feedback controlled by an inductive current. Based on the measured density and temperature profiles, the neoclassical predictions of the bootstrap (with the ambipolar radial electric field taken into account) and the inductive current densities as well as the ECCD from the linear adjoint approach with trapped particles included are calculated. For stationary conditions, the current balance is checked. Launch-angle scans at fixed density as well as density scans at fixed launch-angle are described. Low-frequency MHD mode activity is obtained for strong co-ECCD, and for counter-ECCD a ' ι-bar approx.= 0 feature' with complete loss of the central confinement is found. The linear ECCD prediction is in reasonable agreement with the current balance except for low-density discharges with highly peaked on-axis deposition, where the ECCD predicted from linear theory exceeds by a factor of about 2 the one from the current balance. Since the bootstrap current is well balanced by the inductive current without ECCD, the linear ECCD overestimate is compared with nonlinear Fokker-Planck (FP) simulations, where two different power loss models are used to reach steady state. These volume-averaged FP simulations cannot describe the ECCD degradation at the low densities

  16. Lower hybrid heating and current drive in Iter operation scenarios and outline system design

    International Nuclear Information System (INIS)

    1994-11-01

    Lower Hybrid Waves (LHW) are considered a valid method of plasma heating and the best demonstrated current drive method. Current drive by LHW possesses the unique feature, as compared to the other methods, to retain a good current drive efficiency in plasma regions of low to medium temperature, or in low-β phases of the discharges. This makes them an essential element to realize the so called 'advanced steady-state Tokamak scenarios' in which a hollow current density profile (deep shear reversal) - established during the ramp-up of the plasma current - offers the prospects of improved confinement and an MHD-stable route to continuous burn. This report contains both modelling and design studies of an LHW system for ITER. It aims primarily at the definition of concepts and parameters for steady-state operation using LHW combined with Fast Waves (FW), or other methods of generating a central seed current for high bootstrap current operation. However simulations addressing the use of LHW for current profile control in the high current pulsed operation scenario are also presented. The outline design of a LHW system which covers the needs for both pulsed and steady-state operation is described in detail. (author). 28 refs., 49 figs

  17. Modeling of finite aspect ratio effects on current drive

    International Nuclear Information System (INIS)

    Wright, J.C.; Phillips, C.K.

    1996-01-01

    Most 2D RF modeling codes use a parameterization of current drive efficiencies to calculate fast wave driven currents. This parameterization assumes a uniform diffusion coefficient and requires a priori knowledge of the wave polarizations. These difficulties may be avoided by a direct calculation of the quasilinear diffusion coefficient from the Kennel-Englemann form with the field polarizations calculated by a full wave code. This eliminates the need to use the approximation inherent in the parameterization. Current profiles are then calculated using the adjoint formulation. This approach has been implemented in the FISIC code. The accuracy of the parameterization of the current drive efficiency, η, is judged by a comparison with a direct calculation: where χ is the adjoint function, ε is the kinetic energy, and rvec Γ is the quasilinear flux. It is shown that for large aspect ratio devices (ε → 0), the parameterization is nearly identical to the direct calculation. As the aspect ratio approaches unity, visible differences between the two calculations appear

  18. Modeling of finite aspect ratio effects on current drive

    Energy Technology Data Exchange (ETDEWEB)

    Wright, J.C.; Phillips, C.K. [Princeton Plasma Physics Lab., NJ (United States)

    1996-12-31

    Most 2D RF modeling codes use a parameterization of current drive efficiencies to calculate fast wave driven currents. This parameterization assumes a uniform diffusion coefficient and requires a priori knowledge of the wave polarizations. These difficulties may be avoided by a direct calculation of the quasilinear diffusion coefficient from the Kennel-Englemann form with the field polarizations calculated by a full wave code. This eliminates the need to use the approximation inherent in the parameterization. Current profiles are then calculated using the adjoint formulation. This approach has been implemented in the FISIC code. The accuracy of the parameterization of the current drive efficiency, {eta}, is judged by a comparison with a direct calculation: where {chi} is the adjoint function, {epsilon} is the kinetic energy, and {rvec {Gamma}} is the quasilinear flux. It is shown that for large aspect ratio devices ({epsilon} {r_arrow} 0), the parameterization is nearly identical to the direct calculation. As the aspect ratio approaches unity, visible differences between the two calculations appear.

  19. Intense relativistic electron beam injector system for tokamak current drive

    International Nuclear Information System (INIS)

    Bailey, V.L.; Creedon, J.M.; Ecker, B.M.; Helava, H.I.

    1983-01-01

    We report experimental and theoretical studies of an intense relativistic electron beam (REB) injection system designed for tokamak current drive experiments. The injection system uses a standard high-voltage pulsed REB generator and a magnetically insulated transmission line (MITL) to drive an REB-accelerating diode in plasma. A series of preliminary experiments has been carried out to test the system by injecting REBs into a test chamber with preformed plasma and applied magnetic field. REBs were accelerated from two types of diodes: a conventional vacuum diode with foil anode, and a plasma diode, i.e., an REB cathode immersed in the plasma. REB current was in the range of 50 to 100 kA and REB particle energy ranged from 0.1 to 1.0 MeV. MITL power density exceeded 10 GW/cm 2 . Performance of the injection system and REB transport properties is documented for plasma densities from 5 x 10 12 to 2 x 10 14 cm -3 . Injection system data are compared with numerical calculations of the performance of the coupled system consisting of the generator, MITL, and diode

  20. Technology of fast-wave current drive antennas

    International Nuclear Information System (INIS)

    Hoffman, D.J.; Baity, F.W.; Goulding, R.H.; Haste, G.R.; Ryan, P.M.; Taylor, D.J.; Swain, D.W.; Mayberry, M.J.; Yugo, J.J.

    1989-01-01

    The design of fast-wave current drive (FWCD) antennas combines the usual antenna considerations (e.g., the plasma/antenna interface, disruptions, high currents and voltages, and thermal loads) with new requirements for spectral shaping and phase control. The internal configuration of the antenna array has a profound effect on the spectrum and the ability to control phasing. This paper elaborates on these considerations, as epitomized by a proof-of-principle (POP) experiment designed for the DIII-D tokamak. The extension of FWCD for machines such as the International Thermonuclear Engineering Reactor (ITER) will require combining ideas implemented in the POP experiment with reactor-relevant antenna concepts, such as the folded waveguide. 6 refs., 8 figs

  1. Lower hybrid current drive in Tore Supra and JET

    International Nuclear Information System (INIS)

    Moreau, D.; Gormezano, C.

    1991-01-01

    Recent Lower Hybrid Current Drive (LHCD) experiments in TORE SUPRA and JET are reported. Large multijunction launchers have allowed the coupling of 5MW to the plasma for several seconds with a maximum of 3.8 kW/cm 2 . Measurements of the scattering matrices of the antennae show good agreement with theory. The current drive efficiency in TORE SUPRA is about 0.2 x 10 20 Am -2 /W with LH power alone and reaches 0.4 x 10 20 Am -2 /W in JET thanks to a high volume-averaged electron temperature (1.9 keV) and also to a synergy between Lower Hybrid and Fast Magnetosonic Waves. At n e = 1.5 x 10 19 m -3 in TORE SUPRA, sawteeth are suppressed and m = 1MHD oscillations the frequency of which clearly depends on the amount of LH power are observed on soft X-rays, and also on non-thermal ECE. In Jet ICRH produced sawtooth free periods are extended by the application of LHCD and current profile broadening has been clearly observed consistent with off-axis fast electron populations. LH power modulation experiments performed in TORE SUPRA at n e = 4 x 10 19 m -3 show a delayed central electron heating despite the off-axis creation of suprathermal electrons, thus ruling out the possibility of a direct heating through central wave absorption. A possible explanation in terms of anomalous fast electron transport and classical slowing down would yield a diffusion coefficient of the order of 10 m 2 /s for the fast electrons. Finally, successful pellet fuelling of a partially LH driven plasma was obtained in TORE SUPRA, 28 successive pellets allowing the density to rise to n e = 4 x 10 19 m -3 . This could be achieved by switching the LH power off for 90 ms before each pellet injection, i.e. without modifying significantly the current density profile

  2. Simulation of enhanced tokamak performance on DIII-D using fast wave current drive

    International Nuclear Information System (INIS)

    Grassie, J.S. de; Lin-Liu, Y.R.; Petty, C.C.; Pinsker, R.I.; Chan, V.S.; Prater, R.; John, H. St.; Baity, F.W.; Goulding, R.H.; Hoffman, D.H.

    1993-01-01

    The fast magnetosonic wave is now recognized to be a leading candidate for noninductive current drive for the tokamak reactor due to the ability of the wave to penetrate to the hot dense core region. Fast wave current drive (FWCD) experiments on DIII-D have realized up to 120 kA of rf current drive, with up to 40% of the plasma current driven noninductively. The success of these experiments at 60 MHz with a 2 MW transmitter source capability has led to a major upgrade of the FWCD system. Two additional transmitters, 30 to 120 MHz, with a 2 MW source capability each, will be added together with two new four-strap antennas in early 1994. Another major thrust of the DIII-D program is to develop advanced tokamak modes of operation, simultaneously demonstrating improvements in confinement and stability in quasi-steady-state operation. In some of the initial advanced tokamak experiments on DIII-D with neutral beam heated (NBI) discharges it has been demonstrated that energy confinement time can be improved by rapidly elongating the plasma to force the current density profile to be more centrally peaked. However, this high-l i phase of the discharge with the commensurate improvement in confinement is transient as the current density profile relaxes. By applying FWCD to the core of such a κ-ramped discharge it may be possible to sustain the high internal inductance and elevated confinement. Using computational tools validated on the initial DIII-D FWCD experiments we find that such a high-l i advanced tokamak discharge should be capable of sustainment at the 1 MA level with the upgraded capability of the FWCD system. (author) 16 refs., 3 figs., 1 tab

  3. Naturalistic Driving: A Framework and Advances in Using Big Data

    Directory of Open Access Journals (Sweden)

    Frank Knoefel

    2018-03-01

    Full Text Available Driving is an activity that facilitates physical, cognitive, and social stimulation in older adults, ultimately leading to better physical and cognitive health. However, aging is associated with declines in vision, physical health, and cognitive health, all of which can affect driving ability. One way of assessing driving ability is with the use of sensors in the older adult’s own vehicle. This paper provides a framework for driving assessment and addresses how naturalistic driving studies can assist in such assessments. The framework includes driving characteristics (how much driving, speed, position, type of road, actions and reactions (lane changes, intersections, passing, merging, traffic lights, pedestrians, other vehicles, destinations (variety and distance, sequencing and route planning, and driving conditions (time of day and season. Data from a subset of Ottawa drivers from the Candrive study is used to illustrate the use of naturalistic driving data. Challenges in using naturalistic driving big data and the changing technology in vehicles are discussed.

  4. Electron cyclotron heating and current drive in toroidal geometry

    Energy Technology Data Exchange (ETDEWEB)

    Kritz, A.H.

    1993-03-01

    The Principal Investigator has continued to work on problems associated both with the deposition and with the emission of electron cyclotron heating power electron cyclotron heating in toroidal plasmas. Inparticular, the work has focused on the use of electron cyclotron heating to stabilize q = 1 and q = 2 instabilities in tokamaks and on the use of electron cyclotron emission as a plasma diagnostic. The research described in this report has been carried out in collaboration with scientists at Princeton, MIT and Livermore. The Principal Investigator is now employed at Lehigh University, and a small group effort on electron cyclotron heating in plasmas has begun to evolve at Lehigh involving undergraduate and graduate students. Work has also been done in support of the electron cyclotron heating and current drive program at the Center for Research in Plasma Physics in Lausanne, Switzerland.

  5. Trapped electron effects on ICRF Current Drive Predictions in TFTR

    Science.gov (United States)

    Wright, John C.; Phillips, Cynthia K.; Bonoli, Paul T.

    1996-11-01

    Most 2D RF modeling codes use a parameterization^1 of current drive efficiencies to calculate fast wave driven currents. Because this parameterization is derived from a ray--tracing model, there are difficulties in applying it to a spectrum of waves. In addition, one cannot account for multiple resonances and coherency effects between the electrons and the waves. These difficulties may be avoided by a direct calculation of the quasilinear diffusion coefficient in an inhomogenous geometry coupled with a full wave code for the field polarizations. Current profiles are then calculated using the adjoint formulation^2, with the magnetic equilibrium specified consistently in both the adjoint routine and the full wave code. This approach has been implemented in the FISIC code^3. Results are benchmarked by comparing a power deposition calculation from conductivity to one from the quasilinear expression. It is shown that the two expressions agree. We quantify differences seen based upon aspect ratio and elongation. The largest discrepancies are seen in the regime of small aspect ratio, and little loss in accuracy for moderate aspect ratios ~>3. This work supported by DoE contract No. DE--AC02--76--CH03073. ^1 D. A. Ehst and C. F. F. Karney, Nucl. Fusion 31, 1933 (1991). ^2 C. F. F. Karney, Computer Physics Reports 4, 183 (1986). ^3 M. Brambilla and T. Krücken, Nucl. Fusion 28, 1813 (1988).

  6. Current advances in neutron diffraction stress measurement

    International Nuclear Information System (INIS)

    Suzuki, Hiroshi; Tomota, Yo

    2007-01-01

    Neutron diffraction has been employed for stress evaluation of various mechanical components. The hkl lattice plane spacings in a diffraction gauge volume are measured, then elastic strains are calculated and finally stresses are determined by using the Hooke's law. Since the real engineering mechanical parts are so complicated that more sophisticated method must be progressed to obtain stress distribution in the inside of a sample. Current advances on this issue are reviewed. (author)

  7. Lower hybrid current drive in Tore Supra and jet

    International Nuclear Information System (INIS)

    Moreau, D.; Gormezano, C.

    1991-07-01

    Recent Lower Hybrid Current Drive (LHCD) experiments in TORE SUPRA and JET are reported. Large multijunction launchers have allowed the coupling of 5 MW to the plasma for several seconds with a maximum of 3.8 kW/cm 2 . Measurements of the scattering matrices of the antennae show good agreement with theory. The current drive efficiency in TORE SUPRA is about 0.2 x 10 20 Am -2 /W with LH power alone and reaches 0.4 x 10 20 Am -2 /W in JET thanks to a high volume-averaged electron temperature (1.9 keV) and also to a synergy between Lower Hybrid and Fast Magnetosonic Waves. At average n e = 1.5 x 10 19 m -3 in TORE SUPRA, sawteeth are suppressed and m = 1 MHD oscillations the frequency of which clearly depends on the amount of LH power are observed on soft X-rays, and also on non-thermal ECE. In JET ICRH produced sawtooth-free periods are extended by the application of LHCD (2.9 s. with 4 MW ICRH) and current profile broadening has been clearly observed consistent with off-axis fast electron populations. LH power modulation experiments performed in TORE SUPRA at average n e = 4 x 10 19 m -3 show a delayed central electron heating despite the off-axis creation of suprathermal electrons, thus ruling out the possibility of a direct heating through central wave absorption. A possible explanation in terms of anomalous fast electron transport and classical slowing down would yield a diffusion coefficient of the order of 10 m 2 /s for the fast electrons. Other interpretations such as an anomalous heat pinch or a central confinement enhancement cannot be excluded. Finally, successful pellet fuelling of a partially LH driven plasma was obtained in TORE SUPRA, 28 successive pellets allowing the density to rise to average n e = 4 x 10 19 m -3 . This could be achieved by switching the LH power off for 90 ms before each pellet injection, i.e. without modifying significantly the current density profile

  8. Current profile evolution during fast wave current drive on the DIII-D tokamak

    International Nuclear Information System (INIS)

    Petty, C.C.; Forest, C.B.; Baity, F.W.

    1995-06-01

    The effect of co and counter fast wave current drive (FWCD) on the plasma current profile has been measured for neutral beam heated plasmas with reversed magnetic shear on the DIII-D tokamak. Although the response of the loop voltage profile was consistent with the application of co and counter FWCD, little difference was observed between the current profiles for the opposite directions of FWCD. The evolution of the current profile was successfully modeled using the ONETWO transport code. The simulation showed that the small difference between the current profiles for co and counter FWCD was mainly due to an offsetting change in the o at sign c current proffie. In addition, the time scale for the loop voltage to reach equilibrium (i.e., flatten) was found to be much longer than the FWCD pulse, which limited the ability of the current profile to fully respond to co or counter FWCD

  9. Conditions for Lower Hybrid Current Drive in ITER

    Science.gov (United States)

    Cesario, R.; Amicucci, L.; Cardinali, A.; Castaldo, C.; Ceccuzzi, S.; Napoli, F.; Tuccillo, A. A.; Galli, A.; Schettini, G.

    2012-12-01

    To control the plasma current profile represents one of the most important problems of the research of nuclear fusion energy based on the tokamak concept, as in the plasma column the necessary conditions of stability and confinement should be satisfied. This problem can be solved by using the lower hybrid current drive (LHCD) effect, which was demonstrated to occur also at reactor grade high plasma densities provided that a proper method should be utilised, as assessed on FTU (Frascati Tokamak Upgrade). This method, based on theoretical predictions confirmed by experiment, produces relatively high electron temperature at the plasma periphery and scrape-off layer (SOL), consequently reducing the broadening of the spectrum launched by the antenna produced by parasitic wave physics of the edge, namely parametric instability (PI). The new results presented here show that, for kinetic profiles now foreseen for the SOL of ITER, PI is expected to hugely broaden the antenna spectrum and prevent any penetration in the core of the coupled LH power. However, considering the FTU method and assuming higher electron temperature at the edge (which would be however reasonable for ITER) the PI-produced spectral broadening would be mitigated, and enable the penetration of the coupled LH power in the main plasma. By successful LHCD effect, the control of the plasma current profile at normalised minor radius of about 0.8 would be possible, with much higher efficiency than that obtainable by other tools. A very useful reinforce of bootstrap current effects would be thus possible by LHCD in ITER.

  10. Lower Hybrid Current Drive Experiments in Alcator C-Mod

    Energy Technology Data Exchange (ETDEWEB)

    J.R. Wilson, S. Bernabei, P. Bonoli, A. Hubbard, R. Parker, A. Schmidt, G. Wallace, J. Wright, and the Alcator C-Mod Team

    2007-10-09

    A Lower Hybrid Current Drive (LHCD) system has been installed on the Alcator C-MOD tokamak at MIT. Twelve klystrons at 4.6 GHz feed a 4x22 waveguide array. This system was designed for maximum flexibility in the launched parallel wave-number spectrum. This flexibility allows tailoring of the lower hybrid deposition under a variety of plasma conditions. Power levels up to 900 kW have been injected into the tokomak. The parallel wave number has been varied over a wide range, n|| ~ 1.6–4. Driven currents have been inferred from magnetic measurements by extrapolating to zero loop voltage and by direct comparison to Fisch-Karney theory, yielding an efficiency of n20IR/P ~ 0.3. Modeling using the CQL3D code supports these efficiencies. Sawtooth oscillations vanish, accompanied with peaking of the electron temperature (Te0 rises from 2.8 to 3.8 keV). Central q is inferred to rise above unity from the collapse of the sawtooth inversion radius, indicating off-axis cd as expected. Measurements of non-thermal x-ray and electron cyclotron emission confirm the presence of a significant fast electron population that varies with phase and plasma density. The x-ray emission is observed to be radialy broader than that predicted by simple ray tracing codes. Possible explanations for this broader emission include fast electron diffusion or broader deposition than simple ray tracing predictions (perhaps due to diffractive effects).

  11. Neoclassical Physics for Current Drive in Tokamak Plasmas

    International Nuclear Information System (INIS)

    Duthoit, F.X.

    2012-03-01

    The Lie transform formalism is applied to charged particle dynamics in tokamak magnetic topologies, in order to build a Fokker-Planck type operator for Coulomb collisions usable for current drive. This approach makes it possible to reduce the problem to three dimensions (two in velocity space, one in real space) while keeping the wealth of phase-space cross-term coupling effects resulting from conservation of the toroidal canonical momentum (axisymmetry). This kinetic approach makes it possible to describe physical phenomena related to the presence of strong pressure gradients in plasmas of an unspecified form, like the bootstrap current which role will be paramount for the future ITER machine. The choice of coordinates and the method used are particularly adapted to the numerical resolution of the drift kinetic equation making it possible to calculate the particle distributions, which may present a strong variation with respect to the Maxwellian under the effect of an electric field (static or produced by a radio-frequency wave). This work, mainly dedicated to plasma physics of tokamaks, was extended to those of space plasmas with a magnetic dipole configuration. (author)

  12. Current Behaviours and Attitudes Towards Texting While Driving in Australia

    DEFF Research Database (Denmark)

    Adamsen, Jannie Mia; Beasley, Keiran

    This paper aims to understand the behaviour of texting and driving among the broader driving public in Australia and uncover whether attitudes are congruent with behaviours. Recent studies have generally been focussing on the behaviours of 18-24 year olds suggesting that the practice is mainly...... confined to people in this age bracket. Findings from an anonymous online survey show that the practice of texting and driving is widespread in Australia and not just confined to the younger demographic. Additionally, evidence suggests smart phone users are more likely to engage in texting while driving...

  13. Fokker-Planck modeling of current penetration during electron cyclotron current drive

    International Nuclear Information System (INIS)

    Merkulov, A.; Westerhof, E.; Schueller, F. C.

    2007-01-01

    The current penetration during electron cyclotron current drive (ECCD) on the resistive time scale is studied with a Fokker-Planck simulation, which includes a model for the magnetic diffusion that determines the parallel electric field evolution. The existence of the synergy between the inductive electric field and EC driven current complicates the process of the current penetration and invalidates the standard method of calculation in which Ohm's law is simply approximated by j-j cd =σE. Here it is proposed to obtain at every time step a self-consistent approximation to the plasma resistivity from the Fokker-Planck code, which is then used in a concurrent calculation of the magnetic diffusion equation in order to obtain the inductive electric field at the next time step. A series of Fokker-Planck calculations including a self-consistent evolution of the inductive electric field has been performed. Both the ECCD power and the electron density have been varied, thus varying the well known nonlinearity parameter for ECCD P rf [MW/m -3 ]/n e 2 [10 19 m -3 ] [R. W. Harvey et al., Phys. Rev. Lett 62, 426 (1989)]. This parameter turns out also to be a good predictor of the synergetic effects. The results are then compared with the standard method of calculations of the current penetration using a transport code. At low values of the Harvey parameter, the standard method is in quantitative agreement with Fokker-Planck calculations. However, at high values of the Harvey parameter, synergy between ECCD and E parallel is found. In the case of cocurrent drive, this synergy leads to the generation of large amounts of nonthermal electrons and a concomitant increase of the electrical conductivity and current penetration time. In the case of countercurrent drive, the ECCD efficiency is suppressed by the synergy with E parallel while only a small amount of nonthermal electrons is produced

  14. Heating, current drive and MHD control using ECH in TCV

    International Nuclear Information System (INIS)

    Goodman, T.

    2001-01-01

    The 6 beam 2nd harmonic X-mode (X2), 3MW, ECH/ECCD system of the TCV tokamak allows a fine tailoring of the deposition profiles in the plasma. The sensitivity of the sawtooth period to the deposition location is used to increase the equilibria reconstruction and ray-tracing accuracy. Off-axis ECH, followed by on-axis counter-ECCD produces improved central confinement regimes in which τ Ee exceeds RLW scaling by a factor of 3.5. The PRETOR transport code (incorporating an RLW local transport model but constrained by the experimental density profiles) predicts an extreme sensitivity of τ Ee to the deposition location of the counter-ECCD. This is confirmed by experiments. Sawtooth simulations using PRETOR, including the effects of current drive with inputs from the TORAY ray-tracing code, are in good agreement with experimental results. These results are an initial benchmark for the package of analysis codes, LIUQE/TORAY/PRETOR used during ECH/ECCD experiments on TCV. (author)

  15. The current status of the psychoanalytic theory of instinctual drives. I: Drive concept, classification, and development.

    Science.gov (United States)

    Compton, A

    1983-07-01

    The evolution of Freud's theory of instinctual drives, with the accompanying models of a mental apparatus, is remarkable for its tenacious adherence to addressing the fundamental problems of human psychology, here phrased as the problems of body-mind-environment relationships. The concept of instinctual drives continues to be one of the most pervasive concepts of psychoanalysis, weathering considerable attack over the last several decades, although losing some clarity in the process. I have cited and discussed as basic issues of the concept of instinctual drives: the relationship of observational data and theoretical constructs in psychology; whether our construct of drives is or should be or can be purely psychological; the problem of conceptualizing the ontogenetic origin of mind; the issues of the "force-meaning conjunction" and the problem of psychic energy in psychoanalytic constructs; and the relation of our concept of instinctual drives to the concept of instincts in general. It seems that progress with these fundamental issues might be made by utilizing models that are more homologous with present knowledge in related fields than is Freud's reflex arc model of the nervous system, in order to build a better drive construct within the framework of psychoanalysis. The classification of instinctual drives remains a problem. Clinically, aggression seems to be a factor in conflict, very much like sexuality. Despite widespread acceptance of the idea of aggression as simply parallel to sexuality in all respects, there are major discrepancies. Perhaps aggression cannot be viewed as a drive after all; perhaps our drive construct needs to be modified to accommodate aggression. Certainly, controversy in this area has interfered with the production of good clinical studies which could begin to increase our understanding of aggression and its place in the human personality. The psychoanalytic theory of drive development has probably undergone less change in the last

  16. Recent advances in indirect drive ICF target physics

    International Nuclear Information System (INIS)

    Hammel, B.A.

    2002-01-01

    The National Ignition Facility (NIF), currently under construction, will be used for the study of ignition physics in inertially confined targets, as well as basic and applied research in the field of high energy density science. In preparing for ignition on the NIF, the Lawrence Livermore National Laboratory's Inertial Confinement Fusion Program, in collaboration with Los Alamos National Laboratory (LANL), Sandia National Laboratory (SNL), the Laboratory for Laser Energetics (LLE), General Atomics (GA), and the Commissariat a l'Energie Atomique (CEA), is working to refine ignition designs, develop improved experimental methods, and fabricate and test cryogenic targets required for ignition. This paper will briefly review NIF construction progress, and summarize advances in these areas. (author)

  17. Control systems for ITER diagnostics, heating and current drive

    Energy Technology Data Exchange (ETDEWEB)

    Simrock, Stefan, E-mail: stefan.simrock@iter.org

    2016-11-15

    The ITER Diagnostic, Heating and Current Drive systems might appear, on the face of it, to have very different control requirements. There are approximately 45 diagnostic systems, including magnetic sensors for plasma position and shape determination, imaging systems in the IR and visible, Thompson scattering for electron temperature and density, neutron detectors and collective scattering for alpha particle density and energy distribution. The H&CD systems encompass Electron Cyclotron Heating, using 24 1MW, 170 GHz gyrotrons and 5 steerable launchers to deliver 20 MW to the plasma, Ion Cyclotron Heating, using 8 3MW, 40–55 MHz sources and two multi-element launchers to deliver 20 MW to the plasma, and 2 Negative Ion Neutral Beam Injectors, each of which can deliver up to 16.5 MW of 1 MeV beams to the plasma. Although there are substantial differences in the needs for protection, when handling multi-MW heating systems, and in data throughput for many diagnostics, the formal processes needed to translate system requirements into Instrumentation and Control are identical. Due to the distributed procurement of ITER sub-systems and the need to integrate as painlessly as possible to CODAC, the formal processes, together with a substantial degree of standardization, are even more than usually essential. Starting from the technical, safety and protection, integration and operation requirements, a loop of functional analysis and signal listing is used to generate the controller configuration and the conceptual architecture. These elements in their turn lead to the physical and software design. The paper will describe the formal processes of control system design and the methods used by the ITER project to achieve the standardization of systems engineering practices. These have been applied to several use-cases covering all operation relevant phases such as plasma operation, maintenance, testing and conditioning. There are a number of running contracts that are developing

  18. Lower hybrid current drive at ITER-relevant high plasma densities

    International Nuclear Information System (INIS)

    Cesario, R.; Amicucci, L.; Cardinali, A.; Castaldo, C.; Marinucci, M.; Panaccione, L.; Pericoli-Ridolfini, V.; Tuccillo, A. A.; Tudisco, O.; Calabro, G.

    2009-01-01

    Recent experiments indicated that a further non-inductive current, besides bootstrap, should be necessary for developing advanced scenario for ITER. The lower hybrid current drive (LHCD) should provide such tool, but its effectiveness was still not proved in operations with ITER-relevant density of the plasma column periphery. Progress of the LH deposition modelling is presented, performed considering the wave physics of the edge, and different ITER-relevant edge parameters. Operations with relatively high edge electron temperatures are expected to reduce the LH || spectral broadening and, consequently, enabling the LH power to propagate also in high density plasmas ( || is the wavenumber component aligned to the confinement magnetic field). New results of FTU experiments are presented, performed by following the aforementioned modeling: they indicate that, for the first time, the LHCD conditions are established by operating at ITER-relevant high edge densities.

  19. Advances and current challenges in calcium signaling.

    Science.gov (United States)

    Kudla, Jörg; Becker, Dirk; Grill, Erwin; Hedrich, Rainer; Hippler, Michael; Kummer, Ursula; Parniske, Martin; Romeis, Tina; Schumacher, Karin

    2018-04-01

    Content Summary 414 I. Introduction 415 II. Ca 2+ importer and exporter in plants 415 III. The Ca 2+ decoding toolkit in plants 415 IV. Mechanisms of Ca 2+ signal decoding 417 V. Immediate Ca 2+ signaling in the regulation of ion transport 418 VI. Ca 2+ signal integration into long-term ABA responses 419 VII Integration of Ca 2+ and hormone signaling through dynamic complex modulation of the CCaMK/CYCLOPS complex 420 VIII Ca 2+ signaling in mitochondria and chloroplasts 422 IX A view beyond recent advances in Ca 2+ imaging 423 X Modeling approaches in Ca 2+ signaling 424 XI Conclusions: Ca 2+ signaling a still young blooming field of plant research 424 Acknowledgements 425 ORCID 425 References 425 SUMMARY: Temporally and spatially defined changes in Ca 2+ concentration in distinct compartments of cells represent a universal information code in plants. Recently, it has become evident that Ca 2+ signals not only govern intracellular regulation but also appear to contribute to long distance or even organismic signal propagation and physiological response regulation. Ca 2+ signals are shaped by an intimate interplay of channels and transporters, and during past years important contributing individual components have been identified and characterized. Ca 2+ signals are translated by an elaborate toolkit of Ca 2+ -binding proteins, many of which function as Ca 2+ sensors, into defined downstream responses. Intriguing progress has been achieved in identifying specific modules that interconnect Ca 2+ decoding proteins and protein kinases with downstream target effectors, and in characterizing molecular details of these processes. In this review, we reflect on recent major advances in our understanding of Ca 2+ signaling and cover emerging concepts and existing open questions that should be informative also for scientists that are currently entering this field of ever-increasing breath and impact. © 2018 The Authors. New Phytologist © 2018 New Phytologist Trust.

  20. Current Comparison of Advanced Fuel Cycle Options

    International Nuclear Information System (INIS)

    Steven J. Piet; B. W. Dixon; A. Goldmann; R. N. Hill; J. J. Jacobson; G. E. Matthern; J. D. Smith; A. M. Yacout

    2006-01-01

    The nuclear fuel cycle includes mining, enrichment, nuclear power plants, recycling (if done), and residual waste disposition. The U.S. Advanced Fuel Cycle Initiative (AFCI) has four program objectives to guide research on how best to glue these pieces together, as follows: waste management, proliferation resistance, energy recovery, and systematic management/economics/safety. We have developed a comprehensive set of metrics to evaluate fuel cycle options against the four program objectives. The current list of metrics is long-term heat, long-term dose, radiotoxicity and weapons usable material. This paper describes the current metrics and initial results from comparisons made using these metrics. The data presented were developed using a combination of ''static'' calculations and a system dynamic model, DYMOND. In many cases, we examine the same issue both dynamically and statically to determine the robustness of the observations. All analyses are for the U.S. reactor fleet. This work aims to clarify many of the issues being discussed within the AFCI program, including Inert Matrix Fuel (IMF) versus Mixed Oxide (MOX) fuel, single-pass versus multi-pass recycling, thermal versus fast reactors, and the value of separating cesium and strontium. The results from a series of dynamic simulations evaluating these options are included in this report. The model interface includes a few ''control knobs'' for flying or piloting the fuel cycle system into the future. The results from the simulations show that the future is dark (uncertain) and that the system is sluggish with slow time response times to changes (i.e., what types of reactors are built, what types of fuels are used, and the capacity of separation and fabrication plants). Piloting responsibilities are distributed among utilities, government, and regulators, compounding the challenge of making the entire system work and respond to changing circumstances. We identify four approaches that would increase our chances

  1. Progress in the ITER electron cyclotron heating and current drive system design

    International Nuclear Information System (INIS)

    Omori, Toshimichi; Albajar, Ferran; Bonicelli, Tullio; Carannante, Giuseppe; Cavinato, Mario; Cismondi, Fabio; Darbos, Caroline; Denisov, Grigory; Farina, Daniela; Gagliardi, Mario; Gandini, Franco; Gassmann, Thibault; Goodman, Timothy; Hanson, Gregory; Henderson, Mark A.; Kajiwara, Ken; McElhaney, Karen; Nousiainen, Risto; Oda, Yasuhisa; Oustinov, Alexander

    2015-01-01

    Highlights: • EC system is designed with an ability to upgrade in power to 28 MW then 40 MW. • The TL is capable of 3 buildings movements; ±15 mm displacements at the worst. • Improved power deposition access injecting 20 MW across nearly the entire plasma. • Ensured nuclear safety by appropriate definition of confinement boundaries. • Proposed I&C architecture for the overall EC plant was successfully reviewed. - Abstract: An electron cyclotron system is one of the four auxiliary plasma heating systems to be installed on the ITER tokamak. The ITER EC system consists of 24 gyrotrons with associated 12 high voltage power supplies, a set of evacuated transmission lines and two types of launchers. The whole system is designed to inject 20 MW of microwave power at 170 GHz into the plasma. The primary functions of the system include plasma start-up, central heating and current drive, and magneto-hydrodynamic instabilities control. The design takes present day technology and extends towards high power CW operation, which represents a large step forward as compared to the present state of the art. The ITER EC system will be a stepping stone to future EC systems for DEMO and beyond. The EC system is faced with significant challenges, which not only includes an advanced microwave system for plasma heating and current drive applications but also has to comply with stringent requirements associated with nuclear safety as ITER became the first fusion device licensed as basic nuclear installations as of 9 November 2012. Since conceptual design of the EC system established in 2007, the EC system has progressed to a preliminary design stage in 2012, and is now moving forward towards a final design. The majority of the subsystems have completed the detailed design and now advancing towards the final design completion.

  2. ELECTRON CYCLOTRON CURRENT DRIVE IN DIII-D: EXPERIMENT AND THEORY

    International Nuclear Information System (INIS)

    PRATER, R; PETTY, CC; LUCE, TC; HARVEY, RW; CHOI, M; LAHAYE, RJ; LIN-LIU, Y-R; LOHR, J; MURAKAMI, M; WADE, MR; WONG, K-L

    2003-01-01

    A271 ELECTRON CYCLOTRON CURRENT DRIVE IN DIII-D: EXPERIMENT AND THEORY. Experiments on the DIII-D tokamak in which the measured off-axis electron cyclotron current drive has been compared systematically to theory over a broad range of parameters have shown that the Fokker-Planck code CQL3D provides an excellent model of the relevant current drive physics. This physics understanding has been critical in optimizing the application of ECCD to high performance discharges, supporting such applications as suppression of neoclassical tearing modes and control and sustainment of the current profile

  3. Advanced electric drives analysis, control, and modeling using MATLAB/Simulink

    CERN Document Server

    Mohan, Ned

    2014-01-01

    Advanced Electric Drives utilizes a physics-based approach to explain the fundamental concepts of modern electric drive control and its operation under dynamic conditions. Gives readers a "physical" picture of electric machines and drives without resorting to mathematical transformations for easy visualization Confirms the physics-based analysis of electric drives mathematically Provides readers with an analysis of electric machines in a way that can be easily interfaced to common power electronic converters and controlled using any control scheme Makes the MATLAB/Simulink files used in exampl

  4. Current drive by asymmetrical heating in a toroidal plasma

    International Nuclear Information System (INIS)

    Gahl, J.M.

    1986-01-01

    This report describes the first experimental observation of current generation by asymmetrical heating of ions. A unidirectional fast Alfven wave launched by a slow-wave antenna inside the Texas Tech Tokamak, asymmetrically heated the ions. Measurements of the asymmetry of the toroidal plasma current with probes at the top and bottom of the toroidal plasma column confirmed the current generation indirectly. Current generation, obtained in a one-species, hydrogen plasma, is a phenomenon which had not been predicted previously. Calculations of the dispersion relation for the fast Alfven wave near the fundamental cyclotron resonance in a one-species, hydrogen plasma, using warm plasma theory, support the experimental results

  5. Radio-frequency current drive efficiency in the presence of ITBs and a dc electric field

    International Nuclear Information System (INIS)

    Rosa, P.R. da S; Mourao, R.; Ziebell, L.F.

    2009-01-01

    This paper discusses the current drive efficiency by the combined action of EC and LH waves in the presence of a dc electric field and transport, with an internal transport barrier. The transport is assumed to be produced by magnetic fluctuations. The study explores the different barrier parameters and their influence on the current drive efficiency. We study the subject by numerically solving the Fokker-Planck equation. Our main result is that the barrier depth and barrier width are important to determine the correct shape of the current density profile but not to determine the current drive efficiency, which is very little influenced by these parameters. We also found similar results for the influence of the level of magnetic fluctuations on the current density profile and on the current drive efficiency.

  6. Driving forces shaping advanced reactor designs: Near-term and long-term prospects

    International Nuclear Information System (INIS)

    Sholly, S.C.

    1990-01-01

    This paper explores the forces which have driven and which in the opinion of the author should be driving advanced reactor development programs. Four general driving forces are identified: cost, safety, environmental concerns, and non-proliferation concerns. It is suggested that the primary driving forces should be cost and safety concerns. It is suggested that advanced reactors need to demonstrate the following characteristics: (a) A design which explicitly accounts for severe accidents, including severe external events (not necessarily limited to contemporary design basis events) and which results in a frequency of severe core damage substantially lower than in current plants. The goal for the frequency of severe core damage should reflect a reasonable assurance that a severe core damage accident will not occur during the operating lifetime of a fleet' of such plants. (b) A design which explicitly accounts for severe accidents in terms of accident mitigation, resulting in a very low conditional likelihood of a substantial fission product release given a severe accident. (c) A design which utilizes near-passive and passive concepts (whose safety and reliability are demonstrable by experiment and/or full-scale test) for both accident prevention and accident mitigation to the maximum extent feasible. (d) A design which allows f a suitably long time between refueling outages, with a balance struck between refueling outage duration and refueling outage frequency so as to maximize availability and capacity factor. (e) A design which emphasizes modular construction and exceptional quality control. (f) A design which de emphasizes the importance of maintenance and human reliability more generally to assure that safety functions are performed with acceptable reliability, and to assure that passive safety characteristics are not compromised by design, manufacturing, or installation defects. It is further suggested that key factors in gaining public acceptance are the early

  7. A direct calculation of current drive in toroidal geometry

    International Nuclear Information System (INIS)

    Wright, J.C.; Phillips, C.K.; Bonoli, P.T.

    1998-01-01

    The magnitude and radial profiles of noninductive currents driven by fast magnetosonic waves in tokamaks have been calculated directly from the wave-induced quasilinear flux in a toroidal geometry and a Green's function for the current. An expression for the quasilinear flux has been derived which accounts for coupling between modes in the spectrum of waves launched from the antenna. A Fokker-Planck code for the Green's function and a full wave code for the electric field in the quasilinear flux are used to evaluate the current in a specified toroidal geometry

  8. Design and Construction of Variable Direct Current Speed Drive ...

    African Journals Online (AJOL)

    controlled rectifiers from the viewpoint of simplicity and cost effectiveness to act as power converter and controller. Design and construction of constituent circuits such as acceleration/deceleration, speed and current amplifier and the trigger ...

  9. Novel current drive experiments on the CDX-U, HIT, and DIII-D Tokamaks

    International Nuclear Information System (INIS)

    Ono, M.; Forest, C.B.; Hwang, Y.S.; Armstrong, R.J.; Choe, W.; Darrow, D.S.; Greene, G.; Jones, T.; Schaffer, M.J.; Hyatt, A.W.; Pinsker, R.I.; Staebler, G.M.; Stambaugh, R.D.; Strait, E.J.; Greene, K.L.; Leuer, J.A.; Lohr, J.M.

    1992-01-01

    Two types of novel, non-inductive current drive concepts for starting-up and maintaining tokamak discharges have been developed on the CDX-U, HIT, and DIII-D Tokamaks. On CDX-U, a new, non-inductive current drive technique utilizing fully internally generated pressure driven currents has been demonstrated. The measured current density profile shows a non-hollow profile which agrees with a modeling calculation including helicity conserving non-classical current transport providing the ''seed current''. Another current drive concept, dc-helicity injection, has been investigated on, CDX-U, HIT and DIII-D. This method utilizes injection of magnetic helicity via low energy electron currents, maintaining the plasma current through helicity conserving relaxiation. In these experiments, non-ohmic tokamak plasmas were formed and maintained in the tens of kA range

  10. Synergy between electron cyclotron and lower hybrid current drive on Tore Supra

    International Nuclear Information System (INIS)

    Giruzzi, G.; Artaud, J.F.; Dumont, R.J.; Imbeaux, F.; Bibet, P.; Berger-By, G.; Bouquey, F.; Clary, J.; Darbos, C.; Ekedahl, A.; Hoang, G.T.; Lennholm, M.; Maget, P.; Magne, R.; Segui, J.L.; Bruschi, A.; Granucci, G.

    2005-01-01

    Improvement (up to a factor ∼ 4) of the electron cyclotron (EC) current drive efficiency in plasmas sustained by lower hybrid (LH) current drive has been demonstrated in stationary conditions on the Tore Supra tokamak. This was made possible by feedback controlled discharges at zero loop voltage, constant plasma current and density. This effect, predicted by kinetic theory, results from a favorable interplay of the velocity space diffusions induced by the two waves: the EC wave pulling low-energy electrons out of the Maxwellian bulk, and the LH wave driving them to high parallel velocities. (author)

  11. Comparison between voltage by turn measured on different tokamaks operating in hybrid wave current drive regime

    International Nuclear Information System (INIS)

    Briffod, G.; Hoang, G.T.

    1987-06-01

    On a tokamak in a current drive operation with a hybrid wave, the R.F. current is estimated from the voltage drop by plasma turn generated by R.F. power application. This estimated current is not proportional to the injected power. There still exists in the plasma an electric field corresponding to the current part produced by induction. The role evaluation of this parameter on the current drive efficiency is important. In this report the relation voltage-R.F. current is studied on Petula and results on the voltage evolution by turn on different machines are compared [fr

  12. Review of experiments on current drive in tokamaks by means of RF waves

    International Nuclear Information System (INIS)

    Hooke, W.

    1984-01-01

    Experimental results on lower hybrid current drive in tokamak plasmas are reviewed. Pulse lengths of 3.5 seconds and currents above 400 kA have been generated at plasma densities such that the wave frequency is greater than about twice the lower hybrid frequency. Current drive ceases above a critical density, nsub(c). However, nsub(c) increases with wave frequency. So that for f = 4.6 GHz current drive has been seen at n-barsub(e) approx.= 10 14 cm -3 and a density limit has yet to be established. Evidence for a collisional scaling law for current-drive efficiency is summarized. Detailed measurements of bremsstrahlung x-rays show a distribution which is qualitatively similar to that predicted by quasilinear theory. Microwave emission at frequencies less than the plasma frequency may shed light on the current-drive mechanism. Applications of current drive including plasma and current start-up and transformer recharging are discussed. (author)

  13. Experimental demonstration of synergy between electron cyclotron and lower hybrid current drive on Tore Supra

    International Nuclear Information System (INIS)

    Artaud, J.F.; Giruzzi, G.; Dumont, R.J.; Imbeaux, F.; Bibet, P.; Bouquey, F.; Clary, J.; Ekedahl, A.; Hoang, G.T.; Lennholm, M.; Magne, R.; Segui, J.L.

    2004-01-01

    Non-inductive current drive (CD) has two main applications in tokamaks: sustainment of a substantial fraction of the toroidal plasma current necessary for the plasma confinement and control of the plasma stability and transport properties by appropriate shaping of the current density profile. For the first kind of applications, lower hybrid (LH) waves are known to provide the highest efficiency (defined as the ratio of the driven current to the injected wave power), although with limited control capability. Conversely, electron cyclotron (EC) waves drive highly localized currents, and are therefore particularly suited for control purposes, but their CD efficiency is much lower than that of LH waves (typically, an order of magnitude in present day experiments). Various calculations have demonstrated an interesting property: the current driven by the simultaneous use of the two waves, I(LH+EC), can be significantly larger than the sum I(LH)+I(EC) of the currents separately driven by the two waves in the same plasma conditions. This property, called synergy effect. The peculiar experimental conditions attainable on the Tore Supra tokamak have allowed the first experimental demonstration of the synergy between EC and LH current drive. The significant improvement of the electron cyclotron current drive (ECCD) efficiency in the presence of low hybrid current drive (LHCD), predicted by kinetic theory and confirmed by stationary experiments on Tore Supra, opens up the possibility of using ECCD as an efficient current profile control tool in LHCD plasmas

  14. The essential theory of fast wave current drive with full wave method

    International Nuclear Information System (INIS)

    Liu Yan; Gong Xueyu; Yang Lei; Yin Chenyan; Yin Lan

    2007-01-01

    The full wave numerical method is developed for analyzing fast wave current drive in the range of ion cyclotron waves in tokamak plasmas, taking into account finite larmor radius effects and parallel dispersion. the physical model, the dispersion relation on the assumption of Finite Larmor Radius (FLR) effects and the form of full wave be used for computer simulation are developed. All of the work will contribute to further study of fast wave current drive. (authors)

  15. RF current drive by electron cyclotron waves in the presence of magnetic islands

    Energy Technology Data Exchange (ETDEWEB)

    Da Silva Rosa, P.; Giruzzi, G

    1999-11-01

    The influence of the presence of magnetic islands, and the consequent modification of the tokamak magnetic surface topology, on electron current drive is analyzed. To this end, a new 3D Fokker-Planck code has been developed, taking into account the modifications of the magnetic equilibrium topology owing to the presence of the islands. Significant differences between electron cyclotron current drive efficiency with and without island inside the plasma are found, particularly in the case of interaction with locked modes. (authors)

  16. The advanced smart grid edge power driving sustainability

    CERN Document Server

    Carvallo, Andres

    2011-01-01

    Placing emphasis on practical ""how-to"" guidance, this cutting-edge resource provides you with a first-hand, insider's perspective on the advent and evolution of smart grids in the 21st century (smart grid 1.0). You gain a thorough understanding of the building blocks that comprise basic smart grids, including power plant, transmission substation, distribution, and meter automation. Moreover, this forward-looking volume explores the next step of this technology's evolution. It provides a detailed explanation of how an advanced smart grid incorporates demand response with smart appliances and

  17. Breast cancer stem cells: current advances and clinical implications.

    Science.gov (United States)

    Luo, Ming; Clouthier, Shawn G; Deol, Yadwinder; Liu, Suling; Nagrath, Sunitha; Azizi, Ebrahim; Wicha, Max S

    2015-01-01

    There is substantial evidence that many cancers, including breast cancer, are driven by a population of cells that display stem cell properties. These cells, termed cancer stem cells (CSCs) or tumor initiating cells, not only drive tumor initiation and growth but also mediate tumor metastasis and therapeutic resistance. In this chapter, we summarize current advances in CSC research with a major focus on breast CSCs (BCSCs). We review the prevailing methods to isolate and characterize BCSCs and recent evidence documenting their cellular origins and phenotypic plasticity that enables them to transition between mesenchymal and epithelial-like states. We describe in vitro and clinical evidence that these cells mediate metastasis and treatment resistance in breast cancer, the development of novel strategies to isolate circulating tumor cells (CTCs) that contain CSCs and the use of patient-derived xenograft (PDX) models in preclinical breast cancer research. Lastly, we highlight several signaling pathways that regulate BCSC self-renewal and describe clinical implications of targeting these cells for breast cancer treatment. The development of strategies to effectively target BCSCs has the potential to significantly improve the outcomes for patients with breast cancer.

  18. Lower hybrid current drive for edge current density modification in DIII-D: Final status report

    Energy Technology Data Exchange (ETDEWEB)

    Fenstermacher, M.E. [Lawrence Livermore National Lab., CA (United States); Porkolab, M. [Massachusetts Inst. of Tech., Cambridge, MA (United States). Plasma Fusion Center

    1993-08-04

    Application of Lower Hybrid (LH) Current Drive (CD) in the DIII-D tokamak has been studied at LLNL, off and on, for several years. The latest effort began in February 1992 in response to a letter from ASDEX indicating that the 2.45 GHz, 3 MW system there was available to be used on another device. An initial assessment of the possible uses for such a system on DIII-D was made and documented in September 1992. Multiple meetings with GA personnel and members of the LH community nationwide have occurred since that time. The work continued through the submission of the 1995 Field Work Proposals in March 1993 and was then put on hold due to budget limitations. The purpose of this document is to record the status of the work in such a way that it could fairly easily be restarted at a future date. This document will take the form of a collection of Appendices giving both background and the latest results from the FY 1993 work, connected by brief descriptive text. Section 2 will describe the final workshop on LHCD in DIII-D held at GA in February 1993. This was an open meeting with attendees from GA, LLNL, MIT and PPPL. Summary documents from the meeting and subsequent papers describing the results will be included in Appendices. Section 3 will describe the status of work on the use of low frequency (2.45 GHZ) LH power and Parametric Decay Instabilities (PDI) for the special case of high dielectric in the edge regions of the DIII-D plasma. This was one of the critical issues identified at the workshop. Other potential issues for LHCD in the DIII-D scenarios are: (1) damping of the waves on fast ions from neutral beam injection, (2) runaway electrons in the low density edge plasma, (3) the validity of the WKB approximation used in the ray-tracing models in the steep edge density gradients.

  19. Effects of passive components on the input current interharmonics of adjustable-speed drives

    DEFF Research Database (Denmark)

    Soltani, Hamid; Blaabjerg, Frede; Zare, Firuz

    2016-01-01

    Current and voltage source Adjustable Speed Drives (ASDs) exert distortion current into the grid, which may produce some interharmonic components other than the characteristic harmonic components. This paper studies the effects of passive components on the input current interharmonics of adjustable...... speed drives with and/or without motor current imbalance. The investigation is done at different motor operating frequencies and load torque values. It shows that selecting the small filter components (ac choke, dc choke and dc-link capacitor) results in different performances in respect to those...... interharmincs issued by motor current imbalance and other non-characteristic interharmonics. The results are helpful for engineers investigating the effects of drive filters on the input current interharmonic components....

  20. The drive to strive: goal generation based on current needs

    Directory of Open Access Journals (Sweden)

    Elisabeth A Murray

    2013-06-01

    Full Text Available Hungry animals are influenced by a multitude of different factors when foraging for sustenance. Much of the work on animal foraging has focused on factors relating to the amount of time and energy animals expend searching for and harvesting foods. Models that emphasize such factors have been invaluable in determining when it is beneficial for an animal to search for pastures new. When foraging, however, animals also have to determine how to direct their search. For what food should they forage? There is no point searching for more of a particular food when you are sated from eating it. Here we review work in macaques and humans that has sought to reveal the neural circuits critical for determining the subjective value of different foods and associated objects in our environment and tracking this value over time. There is mounting evidence that a network composed of the orbitofrontal cortex (OFC, amygdala and medial thalamus is critical for linking objects in the environment with food value and adjusting those valuations in real time based on current biological needs. Temporal inactivation studies have revealed that the amygdala and OFC play distinct, but complementary roles in this valuation process. Such a network for determining the subjective value of different foods and, by extension, associated objects, must interact with systems that determine where and for how long to forage. Only by efficiently incorporating these two factors into their decisions will animals be able to achieve maximal fitness.

  1. On current drive by Ohkawa mechanism of electron cyclotron wave in large inverse aspect ratio tokamaks

    Science.gov (United States)

    Zheng, Pingwei; Gong, Xueyu; Lu, Xingqiang; He, Lihua; Cao, Jingjia; Huang, Qianhong; Deng, Sheng

    2018-03-01

    A localized and efficient current drive method in the outer-half region of the tokamak with a large inverse aspect ratio is proposed via the Ohkawa mechanism of electron cyclotron (EC) waves. Further off-axis Ohkawa current drive (OKCD) via EC waves was investigated in high electron beta β e HL-2M-like tokamaks with a large inverse aspect ratio, and in EAST-like tokamaks with a low inverse aspect ratio. OKCD can be driven efficiently, and the driven current profile is spatially localized in the radial region, ranging from 0.62 to 0.85, where the large fraction of trapped electrons provides an excellent advantage for OKCD. Furthermore, the current drive efficiency increases with an increase in minor radius, and then drops when the minor radius beyond a certain value. The effect of trapped electrons greatly enhances the current driving capability of the OKCD mechanism. The highest current drive efficiency can reach 0.183 by adjusting the steering mirror to change the toroidal and poloidal incident angle, and the total driven current by OKCD can reach 20–32 kA MW‑1 in HL-2M-like tokamaks. The current drive is less efficient for the EAST-like scenario due to the lower inverse aspect ratio. The results show that OKCD may be a valuable alternative current drive method in large inverse aspect ratio tokamaks, and the potential capabilities of OKCD can be used to suppress some important magnetohydrodynamics instabilities in the far off-axis region.

  2. Fast wave and electron cyclotron current drive in the DIII-D tokamak

    International Nuclear Information System (INIS)

    Petty, C.C.; Pinsker, R.I.; Austin, M.E.

    1995-01-01

    The non-inductive current drive from directional fast Alfven and electron cyclotron waves was measured in the DIII-D tokamak in order to demonstrate these forms of radiofrequency (RF) current drive and to compare the measured efficiencies with theoretical expectations. The fast wave frequency was 8 times the deuterium cyclotron frequency at the plasma centre, while the electron cyclotron wave was at twice the electron cyclotron frequency. Complete non-inductive current drive was achieved using a combination of fast wave current drive (FWCD) and electron cyclotron current drive (ECCD) in discharges for which the total plasma current was inductively ramped down from 400 to 170 kA. For steady current discharges, an analysis of the loop voltage revealed up to 195 kA of a non-inductive current (out of 310 kA) during combined electron cyclotron and fast wave injection, with a maximum of 110 kA of FWCD and 80 kA of ECCD achieved (not simultaneously). The peakedness of the current profile increased with RF current drive, indicating that the driven current was centrally localized. The FWCD efficiency increased linearly with the central electron temperature as expected; however, the FWCD was severely degraded in low current discharges owing to incomplete fast wave absorption. The measured FWCD agreed with the predictions of a ray tracing code only when a parasitic loss of 4% per pass was included in the modelling along with multiple pass absorption. Enhancement of the second harmonic ECCD efficiency by the toroidal electric field was observed experimentally. The measured ECCD was in good agreement with Fokker-Planck code predictions. (author). 41 refs, 13 figs, 1 tab

  3. MSE measurements for sawtooth and non-inductive current drive studies in KSTAR

    Science.gov (United States)

    Ko, J.; Park, H.; Bea, Y. S.; Chung, J.; Jeon, Y. M.

    2016-10-01

    Two major topics where the measurement of the magnetic-field-line rotational transform profiles in toroidal plasma systems include the long-standing issue of complete versus incomplete reconnection model of the sawtooth instability and the issue with future reactor-relevant tokamak devices in which non-inductive steady state current sustainment is essential. The motional Stark effect (MSE) diagnostic based on the photoelastic-modulator (PEM) approach is one of the most reliable means to measure the internal magnetic pitch, and thus the rotational transform, or its reciprocal (q), profiles. The MSE system has been commissioned for the Korea Superconducting Tokamak Advanced Research (KSTAR) along with the development of various techniques to minimize systematic offset errors such as Faraday rotation and mis-alignment of the bandpass filters. The diagnostic has revealed the central q is well correlated with the sawtooth oscillation, maintaining its value above unity during the MHD quiescent period and that the response of the q profile to external current drive such as electron cyclotron wave injection not only involves the local change of the pitch angle gradient but also a significant shift of the magnetic topology due to the wave energy transport. Work supported by the Ministry of Science, ICT and Future Planning, Korea.

  4. Fast-wave current drive modelling for large non-circular tokamaks

    International Nuclear Information System (INIS)

    Batchelor, D.B.; Goldfinger, R.C.; Jaeger, E.F.; Carter, M.D.; Swain, D.W.; Ehst, D.; Karney, C.F.F.

    1990-01-01

    It is widely recognized that a key element in the development of an attractive tokamak reactor, and in the successful achievement of the mission of ITER, is the development of an efficient steady-state current drive technique. Fast waves in the ion cyclotron range of frequencies hold the promise to drive steady-state currents with the required efficiency and to effectively heat the plasma to ignition. Advantages over other heating and current drive techniques include low cost per watt and the ability to penetrate to the center of high-density plasmas. The primary issues that must be resolved are: can an antenna array be designed to radiate the required spectrum of waves and have adequate coupling properties? Will the rf power be efficiently absorbed by electrons in the desired velocity range without unacceptable parasitic damping by fuel ions or α particles? What will the efficiency of current drive be when toroidal effects such as trapped particles are included? Can a practical rf system be designed and integrated into the device? We have addressed these issues by performing extensive calculations with ORION, a 2-D code, and the ray tracing code RAYS, which calculate wave propagation, absorption and current drive in tokamak geometry, and with RIP, a 2-D code that self-consistently calculates current drive with MHD equilibrium. An important figure of merit in this context is the integrated, normalized current drive efficiency. The calculations that we present here emphasize the ITER device. We consider a low-frequency scenario such that no ion resonances appear in the machine, and a high-frequency scenario such that the deuterium second harmonic resonance is just outside the plasma and the tritium second harmonic is in the plasma, midway between the magnetic axis and the inside edge. In both cases electron currents are driven by combined TTMP and Landau damping of the fast waves

  5. Recovery Act - Sustainable Transportation: Advanced Electric Drive Vehicle Education Program

    Energy Technology Data Exchange (ETDEWEB)

    Caille, Gary

    2013-12-13

    The collective goals of this effort include: 1) reach all facets of this society with education regarding electric vehicles (EV) and plug–in hybrid electric vehicles (PHEV), 2) prepare a workforce to service these advanced vehicles, 3) create web–based learning at an unparalleled level, 4) educate secondary school students to prepare for their future and 5) train the next generation of professional engineers regarding electric vehicles. The Team provided an integrated approach combining secondary schools, community colleges, four–year colleges and community outreach to provide a consistent message (Figure 1). Colorado State University Ventures (CSUV), as the prime contractor, plays a key program management and co–ordination role. CSUV is an affiliate of Colorado State University (CSU) and is a separate 501(c)(3) company. The Team consists of CSUV acting as the prime contractor subcontracted to Arapahoe Community College (ACC), CSU, Motion Reality Inc. (MRI), Georgia Institute of Technology (Georgia Tech) and Ricardo. Collaborators are Douglas County Educational Foundation/School District and Gooru (www.goorulearning.org), a nonprofit web–based learning resource and Google spin–off.

  6. Advanced nuclear power options: The driving forces and their results

    International Nuclear Information System (INIS)

    Golay, M.W.

    1990-01-01

    Successful nuclear power plant concepts must simultaneously demonstrate satisfactory performance in terms of both safety and economics. In order to be attractive to both electric utility companies and the public, such plants must produce economical electric energy consistent with a level of safety which is acceptable to both the public and the plant owner. Programs for reactor development worldwide can be classified according to whether the reactor concept pursues improved safety or improved economic performance as the primary objective. When improved safety is the primary goal, safety enters the solution of the design problem as a constraint which restricts the set of allowed solutions. Conversely, when improved economic performance is the primary goal it is allowed to be pursued only to an extent which is compatible with stringent safety requirements. The three major reactor coolants under consideration for future advanced reactor use are water, helium and sodium. Reactor development programs focused upon safety and upon economics using each coolant are being pursued worldwide. It is seen that the safety-oriented concepts are typically of lower capacity by approximately an order of magnitude, than the economics-oriented concepts. This is the result, in the former concept, of using less efficient, but more reliable, means of accomplishing essential safety functions. (author)

  7. Fast wave current drive in H mode plasmas on the DIII-D tokamak

    International Nuclear Information System (INIS)

    Petty, C.C.; Grassie, J.S. de; Baity, F.W.

    1999-01-01

    Current driven by fast Alfven waves is measured in H mode and VH mode plasmas on the DIII-D tokamak for the first time. Analysis of the poloidal flux evolution shows that the fast wave current drive profile is centrally peaked but sometimes broader than theoretically expected. Although the measured current drive efficiency is in agreement with theory for plasmas with infrequent ELMs, the current drive efficiency is an order of magnitude too low for plasmas with rapid ELMs. Power modulation experiments show that the reduction in current drive with increasing ELM frequency is due to a reduction in the fraction of centrally absorbed fast wave power. The absorption and current drive are weakest when the electron density outside the plasma separatrix is raised above the fast wave cut-off density by the ELMs, possibly allowing an edge loss mechanism to dissipate the fast wave power since the cut-off density is a barrier for fast waves leaving the plasma. (author)

  8. Augmented Reality Head-Up-Display for Advanced Driver Assistance System: A Driving Simulation Study

    OpenAIRE

    HALIT, Lynda; KEMENY, Andras; GARBAYA, Samir; MERIENNE, Frédéric; MICHELIN, Sylvain; ALBAUT, Valentin

    2014-01-01

    Research and technological advance in the field of Augmented Reality (AR) is growing rapidly (Mas, 2011). One of the new application domains is the automobile industry, linked to the necessary men machine aspects of Advanced Driving Assistance Systems (ADAS). Relevant road traffic as well as useful navigation or path planning information may be displayed using partially or totally the windshield surface thanks to these emerging technologies. However, the way road traffic, signs or vehicle inf...

  9. Augmented Reality Head-Up-Display for Advanced Driver Assistance System: A Driving Simulation Study

    OpenAIRE

    HALIT , Lynda; Kemeny , Andras; Mohellebi , Hakim; GARBAYA , Samir; Merienne , Frédéric; Michelin , Sylvain; ALBAUT , Valentin

    2014-01-01

    International audience; Research and technological advance in the field of Augmented Reality (AR) is growing rapidly (Mas, 2011). One of the new application domains is the automobile industry, linked to the necessary men machine aspects of Advanced Driving Assistance Systems (ADAS). Relevant road traffic as well as useful navigation or path planning information may be displayed using partially or totally the windshield surface thanks to these emerging technologies. However, the way road traff...

  10. Current advances in hepatic SPECT imaging

    International Nuclear Information System (INIS)

    Van Heertum, R.L.

    1986-01-01

    Greater accuracy of SPECT imaging is primarily related to improved image contrast and better spatial resolution at increasing distances from the surface of the detector. The SPECT techniques appear to be most accurate in evaluation of liver disease when displayed and interpreted in at least three planes. This approach is particularly important in the evaluation of presence and extent of disease, as well as in the differentiation of intra-versus extra-hepatic disease. SPECT imaging of the liver compares quite well with transmission CAT scanning. The SPECT technique is superior to CAT in the evaluation of diffuse liver disease and is useful for the assessment of both superficial defects and deeper defects throughout the liver. CAT scanning is more useful for the assessment of the porta hepatis and for the evaluation of focal liver disease. The current approach is to recommend the SPECT examination as the first procedure for evaluation of focal and diffuse space-occupying liver disease. Those cases in need of additional diagnostic information are then referred for a CAT scan

  11. Advanced radiation chemistry research: Current status

    International Nuclear Information System (INIS)

    1995-10-01

    Radiation chemistry is a branch of chemistry that studies chemical transformations in materials exposed to high-energy radiations. It is based on the use of ionizing radiation as the initiator or catalyst in chemical reactions. The most significant advantage of radiation chemistry lies in its ability to be used in the production and study of almost any reactive atomic and molecular species playing a part in chemical reaction, synthesis, industrial processes, or in biological systems. Over the the last few years a number of meetings have taken place, under the auspices of the IAEA, in order to evaluate recent developments in radiation chemistry as well as the trends indicated by the results obtained. Radiation chemists from different countries have participated at these meetings. The present publication, a companion to the previous publication - New Trends and Development in Radiation Chemistry, IAEA-TECDOC-527 (1989) - includes some of the important contributions presented at these meetings. It is hoped that it will provide a useful overview of current activities and of emerging trends in this field, thus promoting better understanding of potential contributions of radiation chemistry to other fields of knowledge as well as to practical applications in industry, medicine and agriculture. Refs, figs and tabs

  12. Behavioral cardiology: current advances and future directions.

    Science.gov (United States)

    Rozanski, Alan

    2014-07-08

    Growing epidemiological evidence identifies key domains relevant to behavioral cardiology, including health behaviors, emotions, mental mindsets, stress management, social connectedness, and a sense of purpose. Each of these domains exists along a continuum, ranging from positive factors that promote health, to negative factors, which are pathophysiological. To date, there has been relatively little translation of this growing knowledge base into cardiology practice. Four initiatives are proposed to meet this challenge: 1) promulgating greater awareness of the potency of psychosocial risks factors; 2) overcoming a current "artificial divide" between conventional and psychosocial risk factors; 3) developing novel cost-effective interventions using Internet and mobile health applications, group-based counseling, and development of tiered-care behavioral management; and 4) in recognition that "one size does not fit all" with respect to behavioral interventions, developing specialists who can counsel patients in multidisciplinary fashion and use evidence-based approaches for promoting patient motivation and execution of health goals. Copyright © 2014 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

  13. GENERATING OF OPTIMAL QUANTIZATION LEVELS OF CONTROL CURRENTS FOR LINEAR STEPPING DRIVES OF PRECISION MOTION SYSTEMS

    Directory of Open Access Journals (Sweden)

    I. V. Dainiak

    2014-01-01

    Full Text Available The paper proposes a method of taking into account accumulated and temperature errors while forming coordinate discrete grid of a linear stepping drive. An algorithm for determination of optimal quantization levels of control currents of drive's phases has been developed in the paper; it minimizes an error of positioning that forms correction files for application of a control system in the software. Investigations on stability of discrete grid nodes coordinates have been carried our with the help of a monitoring station for accurate parameters of linear stepping drive. The investigations have proved an efficiency of the proposed algorithm and methodology for forming coordinate discrete grid.

  14. Current-drive by lower hybrid waves in the presence of energetic alpha-particles

    Energy Technology Data Exchange (ETDEWEB)

    Fisch, N.J.; Rax, J.M.

    1991-10-01

    Many experiments have now proved the effectiveness of lower hybrid waves for driving toroidal current in tokamaks. The use of these waves, however, to provide all the current in a reactor is thought to be uncertain because the waves may not penetrate the center of the more energetic reactor plasma, and, if they did, the wave power may be absorbed by alpha particles rather than by electrons. This paper explores the conditions under which lower-hybrid waves might actually drive all the current. 26 refs.

  15. Current-drive by lower hybrid waves in the presence of energetic alpha-particles

    International Nuclear Information System (INIS)

    Fisch, N.J.; Rax, J.M.

    1991-10-01

    Many experiments have now proved the effectiveness of lower hybrid waves for driving toroidal current in tokamaks. The use of these waves, however, to provide all the current in a reactor is thought to be uncertain because the waves may not penetrate the center of the more energetic reactor plasma, and, if they did, the wave power may be absorbed by alpha particles rather than by electrons. This paper explores the conditions under which lower-hybrid waves might actually drive all the current. 26 refs

  16. Lower-hybrid poloidal current drive for fluctuation reduction in a reversed field pinch

    International Nuclear Information System (INIS)

    Uchimoto, E.; Cekic, M.; Harvey, R.W.; Litwin, C.; Prager, S.C.; Sarff, J.S.; Sovinec, C.R.

    1994-06-01

    Current drive using the lower-hybrid slow wave is shown to be a promising candidate for improving confinement properties of a reversed field pinch (RFP). Ray-tracing calculations indicate that the wave will make a few poloidal turns while spiraling radially into a target zone inside the reversal layer. The poloidal antenna wavelength of the lower hybrid wave can be chosen so that efficient parallel current drive will occur mostly in the poloidal direction in this outer region. Three-dimensional resistive magnetohydrodynamic (MHD) computation demonstrates that an additive poloidal current in this region will reduce the magnetic fluctuations and magnetic stochasticity

  17. Modeling of the electron distribution based on bremsstrahlung emission during lower hybrid current drive on PLT

    Energy Technology Data Exchange (ETDEWEB)

    Stevens, J.E.; von Goeler, S.; Bernabei, S.; Bitter, M.; Chu, T.K.; Efthimion, P.; Fisch, N.; Hooke, W.; Hosea, J.; Jobes, F.

    1985-03-01

    Lower hybrid current drive requires the generation of a high energy electron tail anisotropic in velocity. Measurements of bremsstrahlung emission produced by this tail are compared with the calculated emission from reasonable model distributions. The physical basis and the sensitivity of this modeling process are described and the plasma properties of current driven discharges which can be derived from the model are discussed.

  18. Modeling of the electron distribution based on bremsstrahlung emission during lower hybrid current drive on PLT

    International Nuclear Information System (INIS)

    Stevens, J.E.; von Goeler, S.; Bernabei, S.

    1985-03-01

    Lower hybrid current drive requires the generation of a high energy electron tail anisotropic in velocity. Measurements of bremsstrahlung emission produced by this tail are compared with the calculated emission from reasonable model distributions. The physical basis and the sensitivity of this modeling process are described and the plasma properties of current driven discharges which can be derived from the model are discussed

  19. Closure of the single fluid magnetohydrodynamic equations in presence of electron cyclotron current drive

    NARCIS (Netherlands)

    Westerhof, E.; Pratt, J.

    2014-01-01

    In the presence of electron cyclotron current drive (ECCD), the Ohm's law of single fluid magnetohydrodynamics is modified as E + v × B = η(J – J EC). This paper presents a new closure relation for the EC driven current density appearing in this modified Ohm's law. The new relation

  20. Advancing eco-driving strategies for drivers and automated vehicles traveling within intersection vicinities : final report.

    Science.gov (United States)

    2016-01-01

    Vehicle emissions occupy a considerable share of emission inventories in the United States. One of the approaches taken to minimize vehicle emissions is eco-driving. Supported by advanced ITS technologies, it is available to provide the real-time eco...

  1. Evaluation of an Advanced Harmonic Filter for Adjustable Speed Drives using a Toolbox Approach

    DEFF Research Database (Denmark)

    Asiminoaei, Lucian; Hansen, Steffan; Blaabjerg, Frede

    2004-01-01

    A large diversity of solutions exists to reduce the harmonic emission of the 6-pulse Adjustable Speed Drive in order to fulfill the requirements of the international harmonic standards. Among them, new types of advanced harmonic filters recently gained an increased attention due to their good...

  2. Design of the RF system for Alfven wave heating and current drive in a TCA/BR tokamak

    International Nuclear Information System (INIS)

    Ruchko, L.; Andrade, M.L.; Ozono, E.; Galvao, R.M.O.; Degaspari, F.T.; Nascimento, I.C.

    1995-01-01

    The advanced RF system for Alfven wave plasma heating and current drive in TCA/BR tokamak is presented. The antenna system is capable of exciting the standing and travelling wave M = -1,N = 1,N =-4,-6 with single helicity and thus provides the possibility to improve Alfven wave plasma heating efficiency in TCA/BR tokamak and to increase input power level up to P ≅ 1 MW, without the uncontrolled density rise which was encountered in previous TCA (Switzerland) experiments. (author). 4 refs., 3 figs

  3. Analytical calculation of current drive synergy between LH and EC waves

    International Nuclear Information System (INIS)

    Dumont, R.; Giruzzi, G.

    2001-01-01

    An analytical model for the evaluation of electron cyclotron current drive efficiency improvement in lower hybrid current drive regimes is presented. The adjoint equation is written and solved by a perturbation treatment, allowing to derive a response function including both collisional and lower hybrid effects, in the limit where the former still dominate. This allows an analytical demonstration of the current drive synergy effects, previously found by numerical solutions of the kinetic equation. The model is especially useful for the determination of appropriate wave parameters optimizing this synergy effect, such as the EC launching angles suitable for a given LH target plasma. Under these conditions, it is shown that a significant improvement of the ECCD efficiency can be obtained

  4. Numerical calculation of high frequency fast wave current drive in a reactor grade tokamak

    International Nuclear Information System (INIS)

    Ushigusa, Kenkichi; Hamamatsu, Kiyotaka

    1988-02-01

    A fast wave current drive with a high frequency is estimated for a reactor grade tokamak by the ray tracing and the quasi-linear Fokker-Planck calculations with an assumption of single path absorption. The fast wave can drive RF current with the drive efficiency of η CD = n-bar e (10 19 m -3 )I RC (A)R(m)/P RF (W) ∼ 3.0 when the wave frequency is selected to be f/f ci > 7. A sharp wave spectrum and a ph|| >/υ Te ∼ 3.0 are required to obtain a good efficiency. A center peaked RF current profile can be formed with an appropriate wave spectrum even in the high temperature plasma. (author)

  5. Efficiency of LH current drive in tokamaks featuring an internal transport barrier

    International Nuclear Information System (INIS)

    Oliveira, C I de; Ziebell, L F; Rosa, P R da S

    2005-01-01

    In this paper, we study the effects of the occurrence of radial transport of particles in a tokamak on the efficiency of the current drive by lower hybrid (LH) waves, in the presence of an internal transport barrier. The results are obtained by numerical solution of the Fokker-Planck equation which rules the evolution of the electron distribution function. We assume that the radial transport of particles can be due to magnetic or electrostatic fluctuations. In both cases the efficiency of the current drive is shown to increase with the increase of the fluctuations that originate the transport. The dependence of the current drive efficiency on the depth and position of the barrier is also investigated

  6. Recent Improvements to the Control of the CTF3 High-Current Drive Beam

    CERN Document Server

    Constance, B; Gamba, D; Skowronski, P K

    2013-01-01

    In order to demonstrate the feasibility of the CLIC multiTeV linear collider option, the drive beam complex at the CLIC Test Facility (CTF3) at CERN is providing highcurrent electron pulses for a number of related experiments. By means of a system of electron pulse compression and bunch frequency multiplication, a fully loaded, 120 MeV linac is used to generate 140 ns electron pulses of around 28 Amperes. Subsequent deceleration of this high-current drive beam demonstrates principles behind the CLIC acceleration scheme, and produces 12 GHz RF power for experimental purposes. As the facility has progressed toward routine operation, a number of studies aimed at improving the drive beam performance have been carried out. Additional feedbacks, automated steering programs, and improved control of optics and dispersion have contributed to a more stable, reproducible drive beam with consequent benefits for the experiments.

  7. Analysis of JET LCHD/ICRH synergy experiments in terms of relativistic current drive theory

    International Nuclear Information System (INIS)

    Start, D.F.H.; Baranov, Y.; Brusati, M.; Ekedahl, A.; Froissard, P.; Gormezano, C.; Jacquinot, J.; Paquin, L.; Rimini, F.G.; Di Vita, A.

    1994-01-01

    The present analysis shows that the observed efficiency of current drive with synergy between LHCD and ICRH is in good agreement with the relativistic theory of Karney and Fisch for Landau damped waves. The predicted power absorption from the fast wave by the electron tail is within 30% of the measured value. In the presence of significant fast electron diffusion within a slowing down time it would be possible to produce central current drive using multiple ICRF resonances even when the LHCD deposition is at half radius, as in an ITER type device. (authors). 4 refs., 6 figs

  8. A Smart Current Modulation Scheme for Harmonic Reduction in Three- Phase Motor Drive Applications

    DEFF Research Database (Denmark)

    Davari, Pooya; Zare, Firuz; Blaabjerg, Frede

    2015-01-01

    harmonic mitigation methods have been developed over the years, the total cost and complexity has become the main obstacle in employing prior-art methods for motor drive systems. This paper presents a novel current modulation method based on the electronic inductor concept for three-phase ac-dc systems......Electric motor-driven systems consume considerable amount of the global electricity. Majority of three-phase motor drives are equipped with conventional diode rectifier and passive harmonic mitigation, being witnessed as the main source in generating input current harmonics. While many active...

  9. Investigation of the LH wave energy conversion and current drive efficiency in the HT-7 tokamak

    International Nuclear Information System (INIS)

    Chen, Z.Y.; Wan, B.N.; Shi, Y.J.; Lin, S.Y.; Hu, L.Q.; Asif, M.

    2005-01-01

    Lower hybrid current drive (LHCD) plasmas in the presence of DC electric filed have been investigated based on Karney-Fisch theory in the HT-7 tokamak. The relatively small scatter in the experimental data with various values of waveguide phasing and lower hybrid power, when plotted in the Karney-Fisch diagram, confirms that a reasonable theoretical interpretation is possible for the HT-7 data. The full non-inductively current drive efficiencies are obtained by fitting the experimental data to the theoretical curve. The efficiency strongly depends on the lower hybrid wave phase velocity

  10. Compensation methods applied in current control schemes for large AC drive systems

    DEFF Research Database (Denmark)

    Rus, D. C.; Preda, N. S.; Teodorescu, Remus

    2012-01-01

    The paper deals with modified PI current control structures for large AC drive systems which use surface mounted permanent magnet synchronous machines or squirrel-cage induction motors supplied with voltage source inverters. In order to reduce the power losses caused by high frequency switching...... of the semiconductor devices, various compensation methods are used and a modified structure for a PI current controller is proposed, to reduce the switching frequency of the inverter for the same operating frequency of the drive. Simulation, experimental development and test results are presented in order...

  11. An Evolutionary Approach to Driving Tendency Recognition for Advanced Driver Assistance Systems

    Directory of Open Access Journals (Sweden)

    Lee Jong-Hyun

    2016-01-01

    Full Text Available Driving tendency recognition is important for constructing Advanced Driver Assistance Systems (ADAS. However, it had not been a lot of research using vehicle sensing data, due to the high difficulty to define it. In this paper, we attempt to improve the learning capability of a machine learning method using evolutionary computation. We propose a driving tendency recognition method, with consideration of data characteristics. Comparison of our classification system with conventional methods demonstrated the effectiveness and accuracy over 92% in our system. Our proposed evolutionary approach is confirmed that improve the classification accuracy of the learning method through evolution in the experiment.

  12. Theory and experiments on RF plasma heating, current drive and profile control in TORE SUPRA

    Energy Technology Data Exchange (ETDEWEB)

    Moreau, D.

    1994-01-01

    This paper reviews the main experimental and theoretical achievements related to the study of RF heating and non-inductive current drive and particularly phenomena related to the current density profile control and the potentiality of producing stationary enhanced performance regimes: description of the Lower Hybrid (LH) and Ion Cyclotron Resonant Frequency (ICRF) systems; long pulse coupling performance of the RF systems; observation of the transition to the so-called ``stationary LHEP regime`` in which the (flat) central current density and (peaked) electron temperature profiles are fully decoupled; experiments on ICRF sawtooth stabilization with the combined effect of LHCD modifying the current density profile; diffusion of fast electrons generated by LH waves; ramp-up experiments in which the LH power provided a significant part of the resistive poloidal flux and flux consumption scaling; theory of spectral wave diffusion and multipass absorption; fast wave current drive modelling with the Alcyon full wave code; a reflector LH antenna concept. 18 figs., 48 refs.

  13. Theory and experiments on RF plasma heating, current drive and profile control in TORE SUPRA

    International Nuclear Information System (INIS)

    Moreau, D.

    1994-01-01

    This paper reviews the main experimental and theoretical achievements related to the study of RF heating and non-inductive current drive and particularly phenomena related to the current density profile control and the potentiality of producing stationary enhanced performance regimes: description of the Lower Hybrid (LH) and Ion Cyclotron Resonant Frequency (ICRF) systems; long pulse coupling performance of the RF systems; observation of the transition to the so-called ''stationary LHEP regime'' in which the (flat) central current density and (peaked) electron temperature profiles are fully decoupled; experiments on ICRF sawtooth stabilization with the combined effect of LHCD modifying the current density profile; diffusion of fast electrons generated by LH waves; ramp-up experiments in which the LH power provided a significant part of the resistive poloidal flux and flux consumption scaling; theory of spectral wave diffusion and multipass absorption; fast wave current drive modelling with the Alcyon full wave code; a reflector LH antenna concept. 18 figs., 48 refs

  14. The analysis of Alfven wave current drive and plasma heating in TCABR tokamak

    International Nuclear Information System (INIS)

    Ruchko, L.F.; Lerche, E.A.; Galvao, R.M.O.; Elfimov, A.G.; Nascimento, I.C.; Sa, W.P. de; Sanada, E.; Elizondo, J.I.; Ferreira, A.A.; Saettone, E.A.; Severo, J.H.F.; Bellintani, V.; Usuriaga, O.N.

    2002-01-01

    The results of experiments on Alfven wave current drive and plasma heating in the TCABR tokamak are analyzed with the help of a numerical code for simulation of the diffusion of the toroidal electric field. It permits to find radial distributions of plasma current density and conductivity, which match the experimentally measured total plasma current and loop voltage changes, and thus to study the performance of the RF system during Alfven wave plasma heating and current drive experiments. Regimes with efficient RF power input in TCABR have been analyzed and revealed the possibility of noninductive current generation with magnitudes up to ∼8 kA. The increase of plasma energy content due to RF power input is consistent with the diamagnetic measurements. (author)

  15. Measurement of current drive profile using electron cyclotron wave attenuation near the O-mode cutoff

    International Nuclear Information System (INIS)

    Fidone, I.; Meyer, R.L.; Caron, X.

    1992-01-01

    A method for determining the radial profile of the lower-hybrid current drive in tokamaks using electron cyclotron attenuation of the O mode for frequencies ω near the cutoff frequency is discussed. The basic idea is that, for a given wave frequency, the cutoff plays the role of a spatial filter selecting a variable portion of the noninductive current. It is shown that the incremental attenuation resulting from a small increase of ω displays specific features related to the current density near the cutoff point. Using the relation between the wave damping and the current density, it is possible to determine the radial profile of the current drive from the wave attenuation measurements. A numerical application is also presented for plasma parameters in the reactor regime

  16. Complex state variable- and disturbance observer-based current controllers for AC drives

    DEFF Research Database (Denmark)

    Dal, Mehmet; Teodorescu, Remus; Blaabjerg, Frede

    2013-01-01

    , extracted by a disturbance observer and then injected into the current controller. In this study, a revised version of a disturbance observer-based controller and a well known complex variable model-based design with a single set of complex pole are compared in terms of design aspects and performance......In vector-controlled AC drives, the design of current controller is usually based on a machine model defined in synchronous frame coordinate, where the drive performance may be degraded by both the variation of the machine parameters and the cross-coupling between the d- and q-axes components...... of the stator current. In order to improve the current control performance an alternative current control strategy was proposed previously aiming to avoid the undesired cross-coupling and non-linearities between the state variables. These effects are assumed as disturbances arisen in the closed-loop path...

  17. Lower hybrid heating and current drive in ignitor shear reversal scenarios

    Energy Technology Data Exchange (ETDEWEB)

    Barbato, E.; Pinaccione, L. [Italian Agengy for New Technologies, Energy and the Environment, Centro Ricerche Frascati, Rome (Italy). Dip. Energia

    1996-05-01

    Injection of Lower Hybrid (LH) Wave power at 8 GHz is considered into IGNITOR shear reversal scenarios, characterized by a reduced plasma current and density. Power deposition calculation are performed to establish whether LH waves can be used both as central heating and off axis current drive tool. It turns out that LH waves can be used (a) for central plasma heating purpose during the current vamp phase, to freeze the shear reversed configuration, at the power level of {approx}10 MW. (b) to drive a current in the outer part of the plasma at the power level of 20 MW. In this way around 1/3-1/6 of the total current in the proper plasma position (i.e. where q is minimum) is driven.

  18. Beat wave current drive with intense pulsed free-electron lasers

    International Nuclear Information System (INIS)

    Cohen, B.I.; Cohen, R.H.; Logan, B.G.; McCay Nevins, W.; Smith, G.R.; Kluge, A.V.; Kritz, A.H.

    1988-01-01

    High power free-electron lasers make possible new methods for driving current in toroidal devices with electromagnetic waves. Earlier considerations of beat wave current drive are applied to a hot magnetized plasma and an arbitrary beat wave. Here the beating of two electromagnetic waves resonantly excites a low frequency beat wave that accelerates and heats electrons and leads to a current. The absolute current drive efficiency depends non-linearly on the two pump wave intensities and is constrained by the Manley-Rowe relations. Accessibility at high plasma densities is not a difficulty, but a degree of frequency tunability of the wave sources is required. Particle simulations indicate that there is a good coupling to an electron velocity tail for a Langmuir beat wave with a phase velocity 1.5 to 3 times (T e /m e ) 1/2 , so that all of the high frequency wave source is absorbed and the beat wave damps completely on the electrons. A novel diagnostic, based on an analytical solution for the linearized Fokker-Planck equation describing electron scattering and slowing down, is added to the particle code. This permits the computation of the current drive efficiency, including both the non-linear beat wave coupling and the collisional relaxation of the electron distribution. A realistic scenario for a beat wave current drive experiment in the Livermore Microwave Tokamak Experiment is calculated using the TORAY toroidal ray tracing code, and the scaling to an engineering test reactor plasma is described. (author). 23 refs, 8 figs

  19. 60 MHz fast wave current drive experiment for DIII-D

    Energy Technology Data Exchange (ETDEWEB)

    Mayberry, M.J.; Chiu, S.C.; Porkolab, M.; Chan, V.; Freeman, R.; Harvey, R.; Pinsker, R. (General Atomics, San Diego, CA (USA))

    1989-07-01

    The DIII-D facility provides an opportunity to test fast wave current drive appoach. Efficient FWCD is achieved by direct electron absorption due to Landa damping and transit time magnetic pumping. To avoid competing damping mechamisms we seek to maximize the single-pass asorption of the fast waves by electrons. (AIP)

  20. Fast-ion transport and neutral beam current drive in ASDEX upgrade

    DEFF Research Database (Denmark)

    Geiger, B.; Weiland, M.; Jacobsen, Asger Schou

    2015-01-01

    The neutral beam current drive efficiency has been investigated in the ASDEX Upgrade tokamak by replacing on-axis neutral beams with tangential off-axis beams. A clear modification of the radial fast-ion profiles is observed with a fast-ion D-alpha diagnostic that measures centrally peaked profiles...

  1. Implications of rf current drive theory for next step steady-state tokamak design

    International Nuclear Information System (INIS)

    Schultz, J.H.

    1985-06-01

    Two missions have been identified for a next-step tokamak experiment in the United States. The more ambitious Mission II device would be a superconducting tokamak, capable of doing long-pulse ignition demonstrations, and hopefully capable of also being able to achieve steady-state burn. A few interesting lines of approach have been identified, using a combination of logical design criteria and parametric system scans [SC85]. These include: (1) TIBER: A point-design suggested by Lawrence Livermore, that proposes a machine with the capability of demonstrating ignition, high beta (10%) and high Q (=10), using high frequency, fast-wave current drive. The TIBER topology uses moderate aspect ratio and high triangularity to achieve high beta. (2) JET Scale-up. (3) Magic5: It is argued here that an aspect ratio of 5 is a magic number for a good steady-state current drive experiment. A moderately-sized machine that achieves ignition and is capable of high Q, using either fast wave or slow wave current drive is described. (4) ET-II: The concept of a highly elongated tokamak (ET) was first proposed as a low-cost approach to Mission I, because of the possibility of achieving ohmic ignition with low-stress copper magnets. We propose that its best application is really for commercial tokamaks, using fast-wave current drive, and suggest a Mission II experiment that would be prototypical of such a reactor

  2. Heating and current-drive with high phase velocity compressional Alfven waves

    International Nuclear Information System (INIS)

    Li, Y.M.; Mahajan, S.M.; Ross, D.W.

    1986-12-01

    It is shown that high phase velocity compressional Alfven waves have the desirable features needed for efficient current drive in fusion-reactor-like conditions; the energy deposition is low on the α-particles, and high on the hot electrons in the plasma interior

  3. Globalisation and the foreignisation of space: The seven processes driving the current global land grab.

    NARCIS (Netherlands)

    Zoomers, E.B.

    2010-01-01

    The current global land grab is causing radical changes in the use and ownership of land. The main process driving the land grab, or ‘foreignisation of space’, as highlighted in the media and the emerging literature is the production of food and biofuel for export in the aftermath of recent food

  4. On the evaluation of currents in a tokamak plasma during combined Ohmic and RF current drive

    International Nuclear Information System (INIS)

    Eckhartt, D.

    1986-09-01

    By taking into account the rf-generated enhancement of the plasma electric conductivity (as formulated by Fisch in the limit of weak dc electric fields) a relation is derived between the ratio of rf to Ohmically driven currents and other plasma parameters to be measured before and after the rf onset under the condition of constant net plasma current. (author)

  5. Sawtooth control by on-axis electron cyclotron current drive on the WT-3 tokamak

    International Nuclear Information System (INIS)

    Asakawa, M.; Tanabe, K.; Nakayama, A.; Watanabe, M.; Nakamura, M.; Tanaka, H.; Maekawa, T.; Terumichi, Y.

    1999-01-01

    The experiments on control of sawtooth oscillations (STO) by electron cyclotron current drive (ECCD) have been performed on the WT-3 tokamak. Stabilization and excitation of STO are observed for counter-ECCD and co-ECCD, respectively, when the position of the power deposition is located inside the inversion radius. These results are due to the modification of the current profile near the magnetic axis. (author)

  6. Sawtooth control by on-axis electron cyclotron current drive on the WT-3 tokamak

    International Nuclear Information System (INIS)

    Asakawa, M.; Tanabe, K.; Nakayama, A.; Watanabe, M.; Nakamura, M.; Tanaka, H.; Maekawa, T.; Terumichi, Y.

    2001-01-01

    The experiments on control of sawtooth oscillations (STO) by electron cyclotron current drive (ECCD) have been performed on the WT-3 tokamak. Stabilization and excitation of STO are observed for counter-ECCD and co-ECCD, respectively, when the position of the power deposition is located inside the inversion radius. These results are due to the modification of the current profile near the magnetic axis. (author)

  7. Hysteretic self-oscillating bandpass current mode control for Class D audio amplifiers driving capacitive transducers

    DEFF Research Database (Denmark)

    Nielsen, Dennis; Knott, Arnold; Andersen, Michael A. E.

    2013-01-01

    A hysteretic self-oscillating bandpass current mode control (BPCM) scheme for Class D audio amplifiers driving capacitive transducers are presented. The scheme provides excellent stability margins and low distortion over a wide range of operating conditions. Small-signal behavior of the amplifier...... is analysis through transfer function based linear control methodology. Measurements are performed on a single-ended ± 300 V half-bridge amplifier driving a capacitive load of 100 nF. Total Harmonic Distortion plus noise (THD+N) below 0.1 % are reported. Transducers representing a capacitive load and obeying...... the rules of electrostatics have been known as very interesting alternatives to the traditional inefficient electrodynamic transducers. When driving capacitive transducers from a Class D audio amplifier the high impedance nature of the load represents a key challenge. The BPCM control scheme ensures a flat...

  8. An analysis of JET fast-wave heating and current drive experiments directly related to ITER

    International Nuclear Information System (INIS)

    Bhatnagar, V.P.; Eriksson, L.; Gormezano, C.; Jacquinot, J.; Kaye, A.; Start, D.F.H.

    1994-01-01

    The ITER fast-wave system is required to serve a variety of purposes, in particular, plasma heating to ignition, current profile and burn control and eventually, in conjunction with other schemes, a central non-inductive current drive (CD) for the steady-state operation of ITER. The ICRF heating and current drive data that has been obtained in JET are analyzed in terms of dimensionless parameters, with a view to ascertaining its direct relevance to key ITER requirements. The analysis is then used to identify areas both in physics and technological aspects of ion-cyclotron resonance heating (ICRH) and CD that require further experimentation in ITER-relevant devices such as JET to establish the required data base. (authors). 12 refs., 8 figs

  9. Current drive studies for the ARIES steady-state tokamak reactors

    International Nuclear Information System (INIS)

    Mau, T.K.; Ehst, D.A.; Mandrekas, J.

    1994-01-01

    Steady-state plasma operating scenarios are designed for three versions of the ARIES reactor, using non-inductive current drive techniques that have an established database. R.f. waves, including fast and lower hybrid waves, are the reference drivers for the D-T burning ARIES-I and ARIES-II/IV, while neutral beam injection is employed for ARIES-III which burns D- 3 He. Plasma equilibria with a high bootstrap-current component have been used, in order to minimize the recirculating power fraction and cost of electricity. To maintain plasma stability, the driven current profile has been aligned with that of equilibrium by proper choices of the plasma profiles and power launch parameters. Except for ARIES-III, the current-drive power requirements and the relevant technology developments are found to be quite reasonable. The wave-power spectrum and launch requirements are also considered achievable with a modest development effort. Issues such as an improved database for fast-wave current drive, lower-hybrid power coupling to the plasma edge, profile control in the plasma core, and access to the design point of operation remain to be addressed. ((orig.))

  10. Simulations of current density profile control using lower hybrid current drive in the TdeV tokamak

    International Nuclear Information System (INIS)

    Fuchs, V.; Bonoli, P.T.; Shkarofsky, I.P.; Cote, A.; Demers, Y.; Janicki, C.

    1995-01-01

    The physics basis of a simulation model for lower hybrid current drive (LHCD) is discussed. Issues associated with LH power deposition - wave propagation, mode conversion and cut-offs in toroidal geometry, as well as linear and quasi-linear Landau damping - are analysed. A simulation model (ACCOME) is applied to the LHCD experiment now operating on the Tokamak de Varennes (TdeV). The profiles and values of density and temperature needed as inputs to ACCOME are taken from the experiment. The predictions of current density and loop voltage from ACCOME are then compared with experimental LHCD results. Possible LH current profile control experiments are also analysed for TdeV using composite LH spectra to control the location of RF power deposition. Finally, the relevance of these current profile control results to future devices is discussed and an example is shown for ITER-like parameters. (author). 44 refs, 15 figs, 4 tabs

  11. ENHANCING THE OPERATIONAL EFFICIENCY OF DIRECT CURRENT DRIVE BASED ON USE OF SUPERCONDENSER POWER STORAGE UNITS

    Directory of Open Access Journals (Sweden)

    А. M. Mukha

    2017-10-01

    Full Text Available Purpose.The scientific work is intended to analyse the expansion of the load range and the implementation of regeneration braking (RB of the direct current drive by using the supercondenser power storage units. Methodology.To solve the problem, we use the methods of the electric drive theory, impulse electronics and the method of calculation of transient electromagnetic processes in linear electric circuits in the presence of super-condensers therein. Findings.The stiffness of the mechanical and electromechanical characteristics of a series motor is significantly increased, which makes it possible to use a DC drive under load, much smaller than 15…20% of the nominal one. Numerical calculations of the operation process of the supercondenser power storage unit were fulfilled with a sharp decrease in the load of a traction electric motor of a direct current electric locomotive. The possibility of RB of the direct current drive with the series motor is substantiated. The equations of the process of charging and discharging of super-condenser storage unit in RB mode are solved. The authors examined the effect of capacitance on the nature of maintaining the excitation current of an electric motor in the mode of small loads.Originality.The paper developed theoretical approaches for the transformation of soft (mechanical and electromechanical characteristics into hard ones of DC series motors. For the first time a new, combined method of the series motor RB is proposed and substantiated. Further development obtained the methods for evaluating the storage unit parameters, taking into account the criteria for reliable parallel operation of super-condensers with an electric motor field. Practical value.The proposed and substantiated transformation of soft characteristics into stiff ones allows us to use general-purpose electric drives with series motors and at low loads, and in traction electric drives - to reduce the intensity of electric stockwheel

  12. A Phase Current Reconstruction Approach for Three-Phase Permanent-Magnet Synchronous Motor Drive

    Directory of Open Access Journals (Sweden)

    Hao Yan

    2016-10-01

    Full Text Available Three-phase permanent-magnet synchronous motors (PMSMs are widely used in renewable energy applications such as wind power generation, tidal energy and electric vehicles owing to their merits such as high efficiency, high precision and high reliability. To reduce the cost and volume of the drive system, techniques of reconstructing three-phase current using a single current sensor have been reported for three-phase alternating current (AC control system using the power converts. In existing studies, the reconstruction precision is largely influenced by reconstructing dead zones on the Space Vector Pulse Width Modulation (SVPWM plane, which requires other algorithms to compensate either by modifying PWM modulation or by phase-shifting of the PWM signal. In this paper, a novel extended phase current reconstruction approach for PMSM drive is proposed. Six novel installation positions are obtained by analyzing the sampling results of the current paths between each two power switches. By arranging the single current sensor at these positions, the single current sensor is sampled during zero voltage vectors (ZVV without modifying the PWM signals. This proposed method can reconstruct the three-phase currents without any complex algorithms and is available in the sector boundary region and low modulation region. Finally, this method is validated by experiments.

  13. Current Reversal Due to Coupling Between Asymmetrical Driving Force and Ratchet Potential

    International Nuclear Information System (INIS)

    Ai Baoquan; Xie Huizhang; Liu Lianggang

    2006-01-01

    Transport of a Brownian particle moving in a periodic potential is investigated in the presence of an asymmetric unbiased external force. The asymmetry of the external force and the asymmetry of the potential are the two ways of inducing a net current. It is found that the competition of the spatial asymmetry of potential with the temporal asymmetry of the external force leads to the phenomena like current reversal. The competition between the two opposite driving factors is a necessary but not a sufficient condition for current reversals.

  14. Noise and driving induced Brownian heat current in the Frenkel-Kontorova lattices

    Science.gov (United States)

    Chen, Chongyang; Chen, Ruyin; Nie, Linru; Wang, Chaojie; Jia, Youjian

    2018-02-01

    We investigate Brownian heat current induced by noise and driving in the heat conduction of Frenkel-Kontorova (FK) lattices, whose two ends contact respectively with two baths with temporally. Our numerical results indicate that thermal current of the system versus environmental reference temperature exhibits two peaks in symmetric cases, i.e., thermal SR. In asymmetric cases, the phenomenon also takes place, depending on on-site potentials of the atoms exerted on by the periodic signal, but disappears for harmonic lattices. Moreover, its intrinsic physical mechanism is analyzed in detail. The above results play important roles in controlling thermal current of nonlinear lattices.

  15. Current drive with fast waves, electron cyclotron waves, and neutral injection in the DIII-D tokamak

    International Nuclear Information System (INIS)

    Prater, R.; Petty, C.C.; Pinsker, R.I.

    1993-01-01

    Current drive experiments have been performed on the DIII-D tokamak using fast waves, electron cyclotron waves, and neutral injection. Fast wave experiments were performed using a 4-strap antenna with 1 MW of power at 60 MHz. These experiments showed effective heating of electrons, with a global heating efficiency equivalent to that of neutral injection even when the single pass damping was calculated to be as small as 5%. The damping was probably due to the effect of multiple passes of the wave through the plasma. Fast wave current drive experiments were performed with a toroidally directional phasing of the antenna straps. Currents driven by fast wave current drive (FWCD) in the direction of the main plasma current of up to 100 kA were found, not including a calculated 40 kA of bootstrap current. Experiments with FWCD in the counter current direction showed little current drive. In both cases, changes in the sawtooth behavior and the internal inductance qualitatively support the measurement of FWCD. Experiments on electron cyclotron current drive have shown that 100 kA of current can be driven by 1 MW of power at 60 GHz. Calculations with a Fokker-Planck code show that electron cyclotron current drive (ECCD) can be well predicted when the effects of electron trapping and of the residual electric field are included. Experiments on driving current with neutral injection showed that effective current drive could be obtained and discharges with full current drive were demonstrated. Interestingly, all of these methods of current drive had about the same efficiency. (Author)

  16. Application of Electron Bernstein Wave heating and current drive to high beta plasmas

    International Nuclear Information System (INIS)

    Efthimion, P.C.

    2002-01-01

    Electron Bernstein Waves (EBW) can potentially heat and drive current in high-beta plasmas. Electromagnetic waves can convert to EBW via two paths. O-mode heating, demonstrated on W-7AS, requires waves be launched within a narrow k-parallel range. Alternately, in high-beta plasmas, the X-mode cutoff and EBW conversion layers are millimeters apart, so the fast X-mode can tunnel to the EBW branch. We are studying the conversion of EBW to the X-mode by measuring the radiation temperature of the cyclotron emission and comparing it to the electron temperature. In addition, mode conversion has been studied with an approximate kinetic full-wave code. We have enhanced EBW mode conversion to ∼ 100% by encircling the antenna with a limiter that shortens the density scale length at the conversion layer in the scrape off of the CDX-U spherical torus (ST) plasma. Consequently, a limiter in front of a launch antenna achieves efficient X-mode coupling to EBW. Ray tracing and Fokker-Planck codes have been used to develop current drive scenarios in NSTX high-beta (∼ 40%) ST plasmas and a relativistic code will examine the potential synergy of EBW current drive with the bootstrap current. (author)

  17. Current Challenges in the First Principle Quantitative Modelling of the Lower Hybrid Current Drive in Tokamaks

    Science.gov (United States)

    Peysson, Y.; Bonoli, P. T.; Chen, J.; Garofalo, A.; Hillairet, J.; Li, M.; Qian, J.; Shiraiwa, S.; Decker, J.; Ding, B. J.; Ekedahl, A.; Goniche, M.; Zhai, X.

    2017-10-01

    The Lower Hybrid (LH) wave is widely used in existing tokamaks for tailoring current density profile or extending pulse duration to steady-state regimes. Its high efficiency makes it particularly attractive for a fusion reactor, leading to consider it for this purpose in ITER tokamak. Nevertheless, if basics of the LH wave in tokamak plasma are well known, quantitative modeling of experimental observations based on first principles remains a highly challenging exercise, despite considerable numerical efforts achieved so far. In this context, a rigorous methodology must be carried out in the simulations to identify the minimum number of physical mechanisms that must be considered to reproduce experimental shot to shot observations and also scalings (density, power spectrum). Based on recent simulations carried out for EAST, Alcator C-Mod and Tore Supra tokamaks, the state of the art in LH modeling is reviewed. The capability of fast electron bremsstrahlung, internal inductance li and LH driven current at zero loop voltage to constrain all together LH simulations is discussed, as well as the needs of further improvements (diagnostics, codes, LH model), for robust interpretative and predictive simulations.

  18. Simple multijunction launcher with oversized waveguides for lower hybrid current drive on JT-60U

    International Nuclear Information System (INIS)

    Ikeda, Y.; Naito, O.; Seki, M.; Kondoh, T.; Ide, S.; Anno, K.; Fukuda, H.; Ikeda, Y.; Kitai, T.; Kiyono, K.; Sawahata, M.; Shinozaki, S.; Suganuma, K.; Suzuki, N.; Ushigusa, K.

    1994-01-01

    A multijunction technique with oversized waveguides has been developed for the lower hybrid current drive launcher on JT-60U. The launcher consists of 4 (toroidal)x4 (poloidal) multijunction modules. RF power in the module is divided toroidally into 12 sub-waveguides at a junction point through an oversized waveguide. This method simplifies the structure of the multijunction launcher with a large number of subwaveguides. A maximum power density up to 25 MW m -2 has been achieved with a low reflection coefficient of less than 2%. The coupling and current drive efficiency are well explained by the designed wave spectra without taking account of higher modes in the oversize waveguides. Thus, the simple multijunction launcher has been demonstrated to excite expected wave spectra with high power handling capability. ((orig.))

  19. COMPASS-D magnetic equilibria with LH and NBI current drive

    Czech Academy of Sciences Publication Activity Database

    Hronová-Bilyková, Olena; Fuchs, Vladimír; Pánek, Radomír; Urban, Jakub; Žáček, František; Stöckel, Jan; Voitsekhovitch, I.; Valovič, M.; Fitzgerald, M.

    2006-01-01

    Roč. 56, suppl.B (2006), B24-B30 ISSN 0011-4626. [Symposium on Plasma Physics and Technology/22nd./. Praha, 26.6.2006-29.6.2006] Institutional research plan: CEZ:AV0Z20430508 Keywords : tokamak * COMPASS-D * magnetic equilibrium * ACCOME code * ASTRA code * Neutral Beam Injection * Low Hybrid Current Drive Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 0.568, year: 2006

  20. Roof Deformation, Failure Characteristics, and Preventive Techniques of Gob-Side Entry Driving Heading Adjacent to the Advancing Working Face

    Science.gov (United States)

    Bai, Jian-biao; Shen, Wen-long; Guo, Guan-long; Wang, Xiang-yu; Yu, Yang

    2015-11-01

    In mining excavation, the roof bending subsidence of gob-side entry driving heading adjacent to the advancing working face (HAWF) can be considerable. Influenced by the original rock pressure, the front and lateral abutment pressure of the adjacent working face, and the front abutment pressure of the current working face, the support body can easily fail, leading to serious instability of the rock mass surrounding the tunnel. To study the stress state and the deformation failure mechanism of the HAWF roof structure, we use on-site survey data, numerical simulation, and theoretical calculations to fit the spatial distribution law of mining abutment pressure piecewise, and establish a dynamic mechanical model of the roof structure. We then propose a roof failure criterion and examine the roof flexure deformation behavioral pattern. We found that the central part of the roof is the main point that controls the surrounding rock. To prevent the deformation and collapse of the roof and rock surrounding the tunnel, we propose techniques that can be applied to HAWF gob-side entry driving, including setting the coal pillar width, the driving stop and restart timing, and other control concepts.

  1. Theoretical studies of lower hybrid current drive and ion-cyclotron heating in tokamaks

    International Nuclear Information System (INIS)

    Perkins, F.W.; Valeo, E.J.; Eder, D.C.

    1985-02-01

    A computational model for PLT lower hybrid current drive and ramp-up experiments combines a parallel velocity Fokker-Planck treatment of lower hybrid current drive with minor radius flux diffusion and toroidal ray-tracing wave propagation. Computational and experimental results are in good accord. Analytic solutions of the two-dimensional velocity space (v/sub perpendicular/, v/sub parallel/) diffusion problem give values of the current drive parameter J/P/sub d/ which agree with numerical results, both relativistically and nonrelativistically. Turning to ICRF heating, two new all-metal antenna designs will permit power flux up to 10 kW/cm 2 . A full wave solution to the magnetosonic wave equation, based on the parabolic method, yields cylindrical convergence and treats the diffraction limitation on intensity correctly. Mode conversion with energy absorption has been added to the BALDUR ICRF modeling code. A Fokker-Planck treatment of high energy ion tail formation by ICRF finds that enhanced thermonuclear reactivity can occur

  2. Testing advanced driver assistance systems with the interactive driving simulator; Erprobung von Fahrerassistenzsystemen mit dem Interactive Driving Simulator

    Energy Technology Data Exchange (ETDEWEB)

    Friedrichs, A.; Grosse-Kappenberg, S.; Happe, J. [Zentrum fuer Lern- und Wissensmanagement und Lehrstuhl Informatik im Maschinenbau ZLW/IMA der RWTH Aachen (Germany)

    2005-07-01

    The Centre for Learning and Knowledge Management and Department of Computer Science in Engineering of the Technical University Aachen has developed a truck driving simulator which combines a driving simulation as well as traffic flow calculations to the interactive Driving Simulator (InDriveS). In real-time the effects of the driver's behaviour on the surrounding traffic are considered and vice versa. The integrative part of InDriveS is a software-in-the-loop and hardware-in-the-loop development environment. By means of this tool, all phases of development (Analysis, Design, Modelling, Simulation, Implementation as well as Testing and Evaluation) of new vehicle technologies, e.g. Information and Assistance Systems, can be realised in consideration of the road traffic and the driver's behaviour. (orig.)

  3. Load Torque Compensator for Model Predictive Direct Current Control in High Power PMSM Drive Systems

    DEFF Research Database (Denmark)

    Preindl, Matthias; Schaltz, Erik

    2010-01-01

    the use of a current controller which takes into account the discrete states of the inverter, e.g. DTC or a more modern approach: Model Predictive Direct Current Control (MPDCC). Moreover overshoots and oscillations in the speed are not desired in many applications, since they lead to mechanical stress......In drive systems the most used control structure is the cascade control with an inner torque, i.e. current and an outer speed control loop. The fairly small converter switching frequency in high power applications, e.g. wind turbines lead to modest speed control performance. An improvement bring...... behaviour. It compensates the load torque influence on the speed control setting a feed forward torque value, i.e. current reference value. The benefits are twice. The speed controller reaches immediately the speed reference value avoiding offsets which must be compensated by the weak integrator. Moreover...

  4. Leakage Currents and Gas Generation in Advanced Wet Tantalum Capacitors

    Science.gov (United States)

    Teverovsky, Alexander

    2015-01-01

    Currently, military grade, established reliability wet tantalum capacitors are among the most reliable parts used for space applications. This has been achieved over the years by extensive testing and improvements in design and materials. However, a rapid insertion of new types of advanced, high volumetric efficiency capacitors in space systems without proper testing and analysis of degradation mechanisms might increase risks of failures. The specifics of leakage currents in wet electrolytic capacitors is that the conduction process is associated with electrolysis of electrolyte and gas generation resulting in building up of internal gas pressure in the parts. The risk associated with excessive leakage currents and increased pressure is greater for high value advanced wet tantalum capacitors, but it has not been properly evaluated yet. In this work, in Part I, leakages currents in various types of tantalum capacitors have been analyzed in a wide range of voltages, temperatures, and time under bias. Gas generation and the level of internal pressure have been calculated in Part II for different case sizes and different hermeticity leak rates to assess maximal allowable leakage currents. Effects related to electrolyte penetration to the glass seal area have been studied and the possibility of failures analyzed in Part III. Recommendations for screening and qualification to reduce risks of failures have been suggested.

  5. Method for producing silicon thin-film transistors with enhanced forward current drive

    Science.gov (United States)

    Weiner, Kurt H.

    1998-01-01

    A method for fabricating amorphous silicon thin film transistors (TFTs) with a polycrystalline silicon surface channel region for enhanced forward current drive. The method is particularly adapted for producing top-gate silicon TFTs which have the advantages of both amorphous and polycrystalline silicon TFTs, but without problem of leakage current of polycrystalline silicon TFTs. This is accomplished by selectively crystallizing a selected region of the amorphous silicon, using a pulsed excimer laser, to create a thin polycrystalline silicon layer at the silicon/gate-insulator surface. The thus created polysilicon layer has an increased mobility compared to the amorphous silicon during forward device operation so that increased drive currents are achieved. In reverse operation the polysilicon layer is relatively thin compared to the amorphous silicon, so that the transistor exhibits the low leakage currents inherent to amorphous silicon. A device made by this method can be used, for example, as a pixel switch in an active-matrix liquid crystal display to improve display refresh rates.

  6. Driving with advanced vehicle technology: A qualitative investigation of older drivers' perceptions and motivations for use.

    Science.gov (United States)

    Gish, Jessica; Vrkljan, Brenda; Grenier, Amanda; Van Miltenburg, Benita

    2017-09-01

    For older drivers, in-vehicle technology offers much potential to improve safety and increase longevity of retaining both licensure and community mobility. However, little is known about how older drivers perceive Advanced Vehicle Technologies (AVTs) based on everyday driving experience. Interviews with 35 older drivers (20 men; 15 women) aged 60-85 who owned a vehicle with at least two AVTs (e.g., back-up camera, lane departure warning) were conducted to explore the meanings that older drivers assigned to AVTs and motivations for use, including whether age-related functional changes were part of their automobile purchase decision. Findings indicate that age-related changes are not a primary reason for why older adults seek out AVTs, but they still perceived and experienced AVTs to counteract age-related changes in driving performance based upon changes they felt occurring within the body. Older drivers also described AVTs as generating a sense of comfort behind-the-wheel. Comfort with this technology was equated with convenience, ease of use, and increased feelings of safety. Discussion emphasizes how assessments of the quality of driving performance and value of technology occur in relation to an aging body. Copyright © 2016 Elsevier Ltd. All rights reserved.

  7. The production of high poloidal tokamak equilibria in Versator II by means of RF current drive

    International Nuclear Information System (INIS)

    Luckhardt, S.C.; Chen, K.-I.; Kesner, J.; Kirkwood, R.; Lane, B.; Porkolab, M.; Squire, J.

    1989-01-01

    Experiments on the Versator II device have been carried out in a regime of low plasma current with the aim of reaching high poloidal beta, β p . Lower-Hybrid RF current drive is used to produce an energetic electron population which carries the plasma current and pressure. In this mode of operation, plasmas with εβ p approaching unity appear attainable. Data from equilibrium magnetic analysis, hard x-ray, and density profiles display an outward magnetic axis shift in agreement with equilibrium theory, and further indicate that q(O) is in the range of 4-6. PEST code modeling of these experiments suggests that some of these plasmas may be near or beyond the transition to the second stability region for ballooning modes. (author)

  8. Thyristor-based current-fed drive with direct power control for permanent magnet-assisted synchronous reluctance generator

    Science.gov (United States)

    Baek, J.; Kwak, S.-S.; Toliyat, H. A.

    2015-03-01

    This paper proposes a robust and simple direct power control (DPC) of a thyristor-based current-fed drive for generator applications. A current-fed drive and permanent magnet-assisted synchronous reluctance generator (PMa-SynRG) are investigated to deliver 3 kW power using a combustion engine. The current-fed drive utilises a thyristor-based three-phase rectifier to convert generator power to DC-link power and a single-phase current-fed inverter to supply a single-phase inductive load. In addition, a new control algorithm is developed based on DPC for the current-fed drive. The DC-link voltage-based DPC is proposed in order to directly control the output power. The goal of the DPC is to maintain the DC-link voltage at the required output power operating point. The DPC has advantages such as a simple algorithm for constant speed operation. Another feature of the developed current-fed drive is its inherent capability to provide generating action by making the PMa-SynRG operates as a generator, rectifying the phase voltages by means of the three-phase rectifier and feeding the power into the load. These features make the current-fed drive a good candidate for driving any type of synchronous generators including the proposed PMa-SynRG.

  9. Current Drive operation in a In-blanket ICRF Ring Array

    Directory of Open Access Journals (Sweden)

    G.Bosia

    2017-01-01

    Full Text Available The currently predicted Current Drive (CDefficiency in a tokamak reactor plasma is χCD ≤ 50 kA/MW for all auxiliary systems (NBCD, ICCD, ECCD. This would imply a relatively low reactor Q = Pelectric /Pauxiliary and an extremely high power density (>10 MW/m2 at the plasma boundary, if injected through the vacuum vessel ports or by in-port launchers.. In a previous paper the concept of an Ion Cyclotron Ring Array (RA of many elements, integrated in the reactor blanket first wall was proposed. An analysis of this RA operating in steady state Fast Wave Current Drive (FW CD with all elements individually controlled in magnitude and phase is presented in this paper. For CD operation the RA is operated at low frequency (f ≈ 20MHz so as to avoid the otherwise overwhelming RF power absorption by ions and α-particles. It is shown that the RA would feature a very directive radiation spectrum, a low power density operation (avoiding the drawbacks associated with high AC and DC potentials and a potentially high flexibility of operation..

  10. Current Drive operation in a In-blanket ICRF Ring Array

    Science.gov (United States)

    Bosia, G.; Ragona, R.

    2017-10-01

    The currently predicted Current Drive (CD)efficiency in a tokamak reactor plasma is χCD ≤ 50 kA/MW for all auxiliary systems (NBCD, ICCD, ECCD). This would imply a relatively low reactor Q = Pelectric /Pauxiliary and an extremely high power density (>10 MW/m2) at the plasma boundary, if injected through the vacuum vessel ports or by in-port launchers.. In a previous paper the concept of an Ion Cyclotron Ring Array (RA) of many elements, integrated in the reactor blanket first wall was proposed. An analysis of this RA operating in steady state Fast Wave Current Drive (FW CD) with all elements individually controlled in magnitude and phase is presented in this paper. For CD operation the RA is operated at low frequency (f ≈ 20MHz) so as to avoid the otherwise overwhelming RF power absorption by ions and α-particles. It is shown that the RA would feature a very directive radiation spectrum, a low power density operation (avoiding the drawbacks associated with high AC and DC potentials) and a potentially high flexibility of operation..

  11. Fast wave current drive in neutral beam heated plasmas on DIII-D

    International Nuclear Information System (INIS)

    Petty, C.C.; Forest, C.B.; Pinsker, R.I.

    1997-04-01

    The physics of non-inductive current drive and current profile control using the fast magnetosonic wave has been demonstrated on the DIII-D tokamak. In non-sawtoothing discharges formed by neutral beam injection (NBI), the radial profile of the fast wave current drive (FWCD) was determined by the response of the loop voltage profile to co, counter, and symmetric antenna phasings, and was found to be in good agreement with theoretical models. The application of counter FWCD increased the magnetic shear reversal of the plasma and delayed the onset of sawteeth, compared to co FWCD. The partial absorption of fast waves by energetic beam ions at high harmonics of the ion cyclotron frequency was also evident from a build up of fast particle pressure near the magnetic axis and a correlated increase in the neutron rate. The anomalous fast particle pressure and neutron rate increased with increasing NBI power and peaked when a harmonic of the deuterium cyclotron frequency passed through the center of the plasma. The experimental FWCD efficiency was highest at 2 T where the interaction between the fast waves and the beam ions was weakest; as the magnetic field strength was lowered, the FWCD efficiency decreased to approximately half of the maximum theoretical value

  12. Lower hybrid current drive system operated with two klystrons in the HL-1M tokamak

    International Nuclear Information System (INIS)

    Rao Jun; Li Xiaodong; Liu Yong; Xuan Weimin; Yuan Yong; Yang Maoyong; Xie Lifeng

    1999-03-01

    The lower hybrid current drive system on HL-1M was improved significantly in the past two years. The output power for one klystron was increased to 500 kW from previous 200 kW. In order to carry out LHCD experiments with higher RF power, the operation mode of the two klystrons in parallel was used. Some problems were solved, which involved frequency, balance of powers and phase control. With this operation mode, maximum output power of 850 kW was realized, and a series of experiment results were obtained

  13. Electrical conductivity and electron cyclotron current drive efficiencies for non-circular flux surfaces in tokamaks

    International Nuclear Information System (INIS)

    O'Brien, M.R.

    1989-01-01

    As is well known, the presence of electron trapping can strongly reduce the electrical conductivity and rf current drive efficiencies of tokamak plasmas. For example, the conductivity (in the low collisionality limit) of a flux surface with inverse aspect ratio ε=0.1 is approximately one half of the Spitzer conductivity (σ sp )for uniform magnetic fields. Previous estimates of these effects have assumed that the variation of magnetic field strength around a flux surface is given by the standard form for circular flux surfaces. (author) 11 refs., 4 figs

  14. Destabilization of fast particle stabilized sawteeth in ASDEX Upgrade with electron cyclotron current drive

    DEFF Research Database (Denmark)

    Igochine, V.; Chapman, I.T.; Bobkov, V.

    2011-01-01

    It is often observed that large sawteeth trigger the neoclassical tearing mode well below the usual threshold for this instability. At the same time, fast particles in the plasma core stabilize sawteeth and provide these large crashes. The paper presents results of first experiments in ASDEX...... Upgrade for destabilization of fast particle stabilized sawteeth with electron cyclotron current drive (ECCD). It is shown that moderate ECCD from a single gyrotron is able to destabilize the fast particle stabilized sawteeth. A reduction in sawtooth period by about 40% was achieved in first experiments...

  15. What drives the German current account? And how does it affect other EU member states?

    OpenAIRE

    In 'T Veld, Jan; Kollmann, Robert; Ratto, Marco; Roeger, Werner; Vogel, Lukas

    2014-01-01

    We estimate a three-country model using 1995-2013 data for Germany, the Rest of the Euro Area (REA) and the Rest of the World (ROW) to analyze the determinants of Germany’s current account surplus after the launch of the Euro. The most important factors driving the German surplus were positive shocks to the German saving rate and to ROW demand for German exports, as well as German labour market reforms and other positive German aggregate supply shocks. The convergence of REA interest rates to...

  16. Angular distribution of the bremsstrahlung emission during lower-hybrid current drive on PLT

    International Nuclear Information System (INIS)

    von Goeler, S.; Stevens, J.; Bernabei, S.

    1985-06-01

    The bremsstrahlung emission from the PLT tokamak during lower-hybrid current drive has been measured as a function of angle between the magnetic field and the emission direction. The emission is peaked strongly in the forward direction, indicating a strong anisotropy of the electron-velocity distribution. The data demonstrate the existence of a nearly flat tail of the velocity distribution, which extends out to approximately 500 keV and which is interpreted as the plateau created by Landau damping of the lower-hybrid waves

  17. Analyzing Operating Behavior of Hot Mill Table Roll Drives using Statistical Methods for Current Values

    Science.gov (United States)

    Kabakov, P. Z.; Kozhevnikov, A. V.; Ilatovsky, I. S.

    2017-12-01

    The article briefly describes failures of table rolls in Hot Rolling Mill 2000, PAO Severstal, and provides research results obtained by applying statistical methods. The statistical analysis showed a possibility of detecting deviations in roll behavior based on electric drive current changes, which cause failures. The statistical data analysis was employed to define roll critical behavior, which is to be checked using additional data. For this purpose, the research will be continued, roll operating behavior will be studied during the entire lifetime with due regard for deviations detected, comprehensive statistical analysis will be carried out, influence of rolling mill practices and roll failure predictability will be assessed.

  18. Commissioning of the long-pulse fast wave current drive antennas for DIII-D

    International Nuclear Information System (INIS)

    Baity, F.W.; Barber, G.C.; Goulding, R.H.; Hoffman, D.J.; DeGrassie, J.S.; Pinsker, R.I.; Petty, C.C.; Cary, W.

    1995-01-01

    Two new four-element fast wave current drive antennas have been installed on DIII-D. These antennas are designed for 10-s pulses at 2 MW each in the frequency range of 30 to 120 MHz. Each element comprises two poloidal segments fed in parallel in order to optimize plasma coupling at the upper end of the frequency range. The antennas are mounted on opposite sides of the vacuum vessel, in ports designated 0 degrees and 180 degrees after their toroidal angle. Each antenna array is fed by a single transmitter. The power is first split two ways by means of a 3-dB hybrid coupler, then each of these lines feeds a resonant loop connecting a pair of array elements. The power transfer during asymmetric phasing is shunted between resonant loops by a decoupler. The resonant loops are fitted with line stretchers so that multiple frequencies of operation are possible without reconfiguring the transmission line. Commissioning of these antennas has been underway since June 1994. Several deficiencies in the transmission line system were uncovered during initial vacuum conditioning, including problems with the transmission line insulators and with the drive rods for the variable elements. The former was solved by replacing the original alumina insulators, and the latter has been avoided during operation to date by positioning the tuners to avoid high voltage appearing on the drive rods. A modified design for the drive rods will be implemented before RF operations resume operation June 1995. New transmitters were procured from ABB for the new antennas and were installed in parallel with the antenna installation. During initial vacuum conditioning of the antenna in the 180 degree port a fast digital oscilloscope was used to try to pinpoint the location of arcing by a time-of-flight technique and to develop an understanding of the typical arc signature in the system

  19. SIMULATION OF A HIGH-POWERED VARIABLE FREQUENCY AC DRIVE BASED ON A MULTIPULSE CURRENT SOURCE INVERTER

    Directory of Open Access Journals (Sweden)

    G.G. Zhemerov

    2013-10-01

    Full Text Available A computer model building technique for an AC drive system with an autonomous 24-pulse current inverter is introduced. On the basis of the technique developed, a MATLAB variable-frequency drive model capable of working in both quasi-stationary and transient modes is built.

  20. Non-equilibrium reactivation of Na+ current drives early afterdepolarizations in mouse ventricle

    Science.gov (United States)

    Edwards, Andrew G.; Grandi, Eleonora; Hake, Johan E.; Patel, Sonia; Li, Pan; Miyamoto, Shigeki; Omens, Jeffrey H.; Brown, Joan Heller; Bers, Donald M.; McCulloch, Andrew D.

    2015-01-01

    Background Early-afterdepolarizations (EADs) are triggers of cardiac arrhythmia driven by L-type Ca2+ current (ICaL) reactivation or sarcoplasmic reticulum (SR) Ca2+ release and Na+/Ca2+ exchange. In large mammals the positive action potential (AP) plateau promotes ICaL reactivation, and the current paradigm holds that cardiac EAD dynamics are dominated by interaction between ICaL and the repolarizing K+ currents. However, EADs are also frequent in the rapidly repolarizing mouse AP, which should not readily permit ICaL reactivation. This suggests that murine EADs exhibit unique dynamics, which are key for interpreting arrhythmia mechanisms in this ubiquitous model organism. We investigated these dynamics in myocytes from arrhythmia-susceptible CaMKIIδC-overexpressing mice (Tg), and via computational simulations. Methods and Results In Tg myocytes, β-adrenergic challenge slowed late repolarization, potentiated SR Ca2+ release, and initiated EADs below the ICaL activation range (−47±0.7 mV). These EADs were abolished by caffeine and tetrodotoxin (but not Ranolazine), suggesting that SR Ca2+ release and Na+ current (INa), but not late INa, are required for EAD initiation. Simulations suggest that potentiated SR Ca2+ release and Na+/Ca2+ exchange triangulate late AP repolarization, which permits non-equilibrium reactivation of INa, and thereby drives the EAD upstroke. AP clamp experiments suggest that lidocaine eliminates virtually all inward current elicited by EADs, and that this effect occurs at concentrations (40-60 μM) for which lidocaine remains specific for inactivated Na+ channels. This strongly suggests that previously inactive channels are recruited during the EAD upstroke, and that non-equilibrium INa dynamics underlie murine EADs. Conclusions Non-equilibrium reactivation of INa drives murine EADs. PMID:25236710

  1. 4 MW upgrade to the DIII-D fast wave current drive system

    Energy Technology Data Exchange (ETDEWEB)

    deGrassie, J.S.; Pinsker, R.I.; Cary, W.P.

    1993-10-01

    The DIII-D fast wave current drive (FWCD) system is being upgraded by an additional 4 MW in the 30 to 120 MHz frequency range. This capability adds to the existing 2 MW 30 to 60 MHz system. Two new ABB transmitters of the type that are in use on the ASDEX-Upgrade tokamak in Garching will be used to drive two new water-cooled four-strap antennas to be installed in DIII-D in early 1994. The transmission and tuning system for each antenna will be similar to that now in use for the first 2 MW system on DIII-D, but with some significant improvements. One improvement consists of adding a decoupler element to counter the mutual coupling between the antenna straps which results in large imbalances in the power to a strap for the usual current drive intrastrap phasing of 90{degrees}. Another improvement is to utilize pressurized, ceramic-insulated transmission lines. The intrastrap phasing will again be controlled in pairs, with a pair of straps coupled in a resonant loop configuration, locking their phase difference at either 0 or 180{degrees}, depending upon the length of line installed. These resonant loops will incorporate a phase shifter so that they will be able to be tuned to resonance at several frequencies in the operating band of the transmitter. With the frequency change capability of the ABB generators, the FWCD frequency will thus be selectable on a shot-to-shot basis, from this preselected set of frequencies. The schedule is for experiments to begin with this added 4 MW capability in mid-1994. The details of the system are described.

  2. Current development status of advanced pressurized water reactors (APWRs)

    International Nuclear Information System (INIS)

    Seifritz, W.; Chawla, R.

    1985-08-01

    The current development status of advanced (high converting) pressurized water reactors (APWRs) is briefly reviewed. The areas covered are: reactor physics, thermohydraulics and other technical aspects, as well as electricity generating costs and longterm reactor strategical considerations related to the APWR's role in a plutonium economy. There does not seem to be any unsurmountable technical obstacle to the realization of an APWR. However, substantial further R and D efforts are required if an APWR is to go into commercial operation by the end of the century. (author)

  3. EC + LH current drive efficiency in the presence of an internal transport barrier

    International Nuclear Information System (INIS)

    Rosa, P.R. da S; Ziebell, L.F.

    2002-01-01

    In this paper we study the effects of the presence of an internal transport barrier (ITB) on the current drive efficiency and power deposition profiles in the case of electron cyclotron waves interacting with an extended tail generated by lower hybrid (LH) waves. We study the subject by numerically solving the Fokker-Planck equation, with temperature and density profiles corrected along the time evolution at each collision time, based on the actual time-evolving electron distribution function. The results obtained show that the LH and electron cyclotron (EC) power absorption profiles and the current driven by the combined action of both types of waves are weakly dependent on the depth of the ITB, slightly more dependent on the level of magnetic turbulence and much more dependent on the level of EC wave power. (author)

  4. PERFORMANCE STUDIES OF INTEGRATED FUZZY LOGIC CONTROLLER FOR BRUSHLESS DC MOTOR DRIVES USING ADVANCED SIMULATION MODEL

    Directory of Open Access Journals (Sweden)

    C. Subba Rami Reddy

    2011-07-01

    Full Text Available This paper introduces an Integrated fuzzy logic controller (IFLC for brushless dc (BLDC motor drives using advanced simulation model and presents a comparative study of performances of PID controller and IFLC. The dynamic characteristics of speed and torque are effectively monitored and analyzed using the proposed model. The aim of IFLC is to obtain improved performance in terms of disturbance rejection or parameter variation than obtained using PID controller. The IFLC is constructed by using Fuzzy logic controller (FLC and PID controller. A performance comparison of the controllers is also given based on the integral of the absolute value of the error (IAE, the integral of the squared error (ISE, the integral of the time-weighted absolute error (ITAE and the integral of the time-weighted squared error (ITSE. The results show the effectiveness of the proposed controller.

  5. High power lower hybrid current drive experiment in TORE SUPRA tokamak

    International Nuclear Information System (INIS)

    Peysson, Y.

    2001-01-01

    A review of the Lower Hybrid (LH) current drive experiments carried out on the TORE SUPRA tokamak is presented. This work highlights the issues for an effective application of the LH wave at high power in reactor relevant conditions. Very promising performances have been obtained with the new launcher that is designed to couple up to 4 MW during 1000 s at a power density of 25 MWm -2 . The heat load on the guard limiter of the antenna and the fast electron acceleration in the near electric field of the grill mouth remain at a low level, while the mean reflection coefficient never exceeds 10%. The powerful diagnosis capabilities of the hard x-ray (HXR) fast electron bremsstrahlung tomography has led to significant progresses in the understanding of the LH wave dynamics. The role of the fastest electrons driven by the LH wave is clearly identified. From HXR measurements, an increase of the LH current drive efficiency with the plasma current is predicted and confirmed by a direct determination at zero loop voltage. LH power absorption is observed to be off-axis in almost all plasma conditions, and its radial width clearly depends of antenna phasing conditions. A correlation between the HXR profiles and the onset of an improved core confinement is identified in fully non-inductive discharges. This regime ascribed to some vanishing of the magnetic shear is found to be transient and usually ends when the minimum of the safety factor becomes very close to 2, leading to a large MHD activity. Experimental observations and numerical simulations suggest that LH power is absorbed in a few number of passes. However, besides toroidal mode coupling, additional mechanisms may likely contribute to a spectral broadening to the LH wave. (author)

  6. Controlling fluctuations and transport in the reversed field pinch with edge current drive and plasma biasing

    International Nuclear Information System (INIS)

    Craig, D.J.G.

    1998-09-01

    Two techniques are employed in the Madison Symmetric Torus (MST) to test and control different aspects of fluctuation induced transport in the Reversed Field Pinch (RFP). Auxiliary edge currents are driven along the magnetic field to modify magnetic fluctuations, and the particle and energy transport associated with them. In addition, strong edge flows are produced by plasma biasing. Their effect on electrostatic fluctuations and the associated particle losses is studied. Both techniques are accomplished using miniature insertable plasma sources that are biased negatively to inject electrons. This type of emissive electrode is shown to reliably produce intense, directional current without significant contamination by impurities. The two most important conclusions derived from these studies are that the collective modes resonant at the reversal surface play a role in global plasma confinement, and that these modes can be controlled by modifying the parallel current profile outside of the reversal surface. This confirms predictions based on magnetohydrodynamic (MHD) simulations that auxiliary current drive in the sense to flatten the parallel current profile can be successful in controlling magnetic fluctuations in the RFP. However, these studies expand the group of magnetic modes believed to cause transport in MST and suggest that current profile control efforts need to address both the core resonant magnetic modes and those resonant at the reversal surface. The core resonant modes are not significantly altered in these experiments; however, the distribution and/or amplitude of the injected current is probably not optimal for affecting these modes. Plasma biasing generates strong edge flows with shear and particle confinement likely improves in these discharges. These experiments resemble biased H modes in other magnetic configurations in many ways. The similarities are likely due to the common role of electrostatic fluctuations in edge transport

  7. Role of the lower hybrid spectrum in the current drive modeling for DEMO scenarios

    Science.gov (United States)

    Cardinali, A.; Castaldo, C.; Cesario, R.; Santini, F.; Amicucci, L.; Ceccuzzi, S.; Galli, A.; Mirizzi, F.; Napoli, F.; Panaccione, L.; Schettini, G.; Tuccillo, A. A.

    2017-07-01

    The active control of the radial current density profile is one of the major issues of thermonuclear fusion energy research based on magnetic confinement. The lower hybrid current drive could in principle be used as an efficient tool. However, previous understanding considered the electron temperature envisaged in a reactor at the plasma periphery too large to allow penetration of the coupled radio frequency (RF) power due to strong Landau damping. In this work, we present new numerical results based on quasilinear theory, showing that the injection of power spectra with different {n}// widths of the main lobe produce an RF-driven current density profile spanning most of the outer radial half of the plasma ({n}// is the refractive index in a parallel direction to the confinement magnetic field). Plasma kinetic profiles envisaged for the DEMO reactor are used as references. We demonstrate the robustness of the modeling results concerning the key role of the spectral width in determining the lower hybrid-driven current density profile. Scans of plasma parameters are extensively carried out with the aim of excluding the possibility that any artefact of the utilised numerical modeling would produce any novelty. We neglect here the parasitic effect of spectral broadening produced by linear scattering due to plasma density fluctuations, which mainly occurs for low magnetic field devices. This effect will be analyzed in other work that completes the report on the present breakthrough.

  8. Alternative Design Study Report: WindPACT Advanced Wind Turbine Drive Train Designs Study; November 1, 2000 -- February 28, 2002

    Energy Technology Data Exchange (ETDEWEB)

    Poore, R.; Lettenmaier, T.

    2003-08-01

    This report presents the Phase I results of the National Renewable Energy Laboratory's (NREL's) WindPACT (Wind Partnership for Advanced Component Technologies) Advanced Wind Turbine Drive Train Designs Study. Global Energy Concepts, LLC performed this work under a subcontract with NREL. The purpose of the WindPACT project is to identify technology improvements that will enable the cost of energy (COE) from wind turbines to be reduced. Other parts of the WindPACT project have examined blade and logistics scaling, balance-of-station costs, and rotor design. This study was designed to investigate innovative drive train designs.

  9. Effects of ion cyclotron harmonic damping on current drive in the lower hybrid frequency range

    International Nuclear Information System (INIS)

    Wong, K.L.; Ono, M.

    1983-11-01

    We investigate the ion cyclotron harmonic damping effects on slow and fast waves in the lower hybrid frequency range for tokamak reactor parameters. Inclusion of the higher order terms in the hot plasma dielectric tensor introduces ion cyclotron harmonic damping; these terms also contribute to the real part of the dispersion relation and affect the wave trajectories. However, wave absorption by 15 keV deuterium and tritium ions can be avoided by choosing the slow wave frequency above the lower hybrid frequency and the fast wave frequency below the lower hybrid frequency. But preliminary estimates show that energetic alpha particles tend to absorb both the slow and the fast waves. This absorption may become a serious obstacle for fusion-reactor current drive in the lower hybrid frequency range

  10. Electron cyclotron heating and current drive in toroidal geometry. Technical progress report

    Energy Technology Data Exchange (ETDEWEB)

    Kritz, A.H.

    1993-03-01

    The Principal Investigator has continued to work on problems associated both with the deposition and with the emission of electron cyclotron heating power electron cyclotron heating in toroidal plasmas. Inparticular, the work has focused on the use of electron cyclotron heating to stabilize q = 1 and q = 2 instabilities in tokamaks and on the use of electron cyclotron emission as a plasma diagnostic. The research described in this report has been carried out in collaboration with scientists at Princeton, MIT and Livermore. The Principal Investigator is now employed at Lehigh University, and a small group effort on electron cyclotron heating in plasmas has begun to evolve at Lehigh involving undergraduate and graduate students. Work has also been done in support of the electron cyclotron heating and current drive program at the Center for Research in Plasma Physics in Lausanne, Switzerland.

  11. Compact ASD Topologies for Single-Phase Integrated Motor Drives with Sinusoidal Input Current

    DEFF Research Database (Denmark)

    Klumpner, Christian; Blaabjerg, Frede; Thoegersen, Paul

    2005-01-01

    A standard configuration of an Adjustable Speed Drive (ASD) consists of two separate units: an AC motor, which runs with fixed speed when it is supplied from a constant frequency grid voltage and a frequency converter, which is used to provide the motor with variable voltage-variable frequency......-density integration of the converter caused by the large size of the passive components (electrolytic capacitors and iron chokes) and vibration of the converter enclosure. This paper analyzes the implementation aspects for obtaining a compact and cost effective single-phase ASD with sinusoidal input current...... for high frequency operation, higher core losses will occur, but outside the converter enclosure. The advantages are: the reduction of the number of active semiconductor devices, the reduction of the ASD size and the better integration potential....

  12. Traveling-wave antenna for fast-wave heating and current drive in tokamaks

    International Nuclear Information System (INIS)

    Ikezi, H.; Phelps, D.A.

    1997-01-01

    The travelling-wave antenna for heating and current drive in the ion cyclotron range of frequencies is shown theoretically to have loading and wavenumber spectra that are largely independent of plasma conditions. These characteristics have been demonstrated in low-power experiments on the DIII-D tokamak, in which a standard four-strap antenna was converted to a traveling-wave antenna through use of external coupling elements. The experiments indicate that the array maintains good impedance matching without dynamic tuning during abrupt changes in the plasma, such as during L- to H-mode transitions, edge-localized mode activity, and disruptions. An analytic model was developed that exhibits the features observed in the experiments. Guidelines for the design of travelling-wave antennas are derived from the validated model. 11 refs., 14 figs

  13. Traveling wave antenna for fast wave heating and current drive in tokamaks

    International Nuclear Information System (INIS)

    Ikezi, H.; Phelps, D.A.

    1995-07-01

    The traveling wave antenna for heating and current drive in the ion cyclotron range of frequencies is shown theoretically to have loading and wavenumber spectrum which are largely independent of plasma conditions. These characteristics have been demonstrated in low power experiments on the DIII-D tokamak, in which a standard four-strap antenna was converted to a traveling wave antenna through use of external coupling elements. The experiments indicate that the array maintains good impedance matching without dynamic tuning during abrupt changes in the plasma, such as during L- to H-mode transitions, edge localized mode activity, and disruptions. An analytic model was developed which exhibits the features observed in the experiments. Guidelines for the design of traveling wave antennas are derived from the validated model

  14. RAMI Analysis of Neutral Beam Heating and Current Drive System for ITER

    International Nuclear Information System (INIS)

    Chang, Doo Hee; Lee, Sang Il

    2009-01-01

    A RAMI (Reliability, Availability, Maintainability, Inspectability) analysis has been performed for the neutral beam (NB) heating and current drive (H and CD) system of ITER (International Thermonuclear Experimental Reactor) device. The objective of this analysis is to implement RAMI engineering requirements for the design and testing to prepare a reliability-centred plan for commissioning, operation, and maintenance of the system in the framework of a technical risk control to support the overall ITER Project. These RAMI requirements will correspond to the RAMI targets for the ITER project and the compensating provisions to reach them as deduced from the necessary actions to decrease the risk level of the function failure modes. The RAMI analyses have to match with the procurement plan of the system

  15. Current drive by EC waves in the presence of magnetic islands and transport

    International Nuclear Information System (INIS)

    Rosa, P R da S; Ziebell, L F

    2008-01-01

    In this paper we address the problem of current drive by electron cyclotron (EC) waves in the presence of magnetic islands and transport. Our approach makes use of quasilinear theory by numerically solving the Fokker-Planck equation in cylindrical geometry. We take into account the actual geometry of the islands along the calculations as well as the changes in the plasma density profile due to the action of the radial particle transport. The particle transport is supposed to have a magnetic origin. The waves are assumed to be launched and propagated in the equatorial plane of the tokamak, as in the slab geometry. Our results show that the use of equilibrium profiles as usually done in the studies on neoclassical tearing mode control may not be a better choice and point to the need for taking into account the actual island geometry

  16. HHFW Heating and Current Drive Studies of NSTX H-Mode Plasmas

    Energy Technology Data Exchange (ETDEWEB)

    G. Taylor, P.T. Bonoli, D.L. Green, R.W. Harvey, J.C. Hosea, E.F. Jaeger, B.P. LeBlanc, R. Maingi, C.K. Phillips, P.M. Ryan, E.J. Valeo, J.R. Wilson, J.C. Wright, and the NSTX Team

    2011-06-08

    30 MHz high-harmonic fast wave (HHFW) heating and current drive are being developed to assist fully non-inductive plasma current (I{sub p}) ramp-up in NSTX. The initial approach to achieving this goal has been to heat I{sub p} = 300 kA inductive plasmas with current drive antenna phasing in order to generate an HHFW H-mode with significant bootstrap and RF-driven current. Recent experiments, using only 1.4 MW of RF power (P{sub RF}), achieved a noninductive current fraction, f{sub NI} {approx} 0.65. Improved antenna conditioning resulted in the generation of I{sub p} = 650 kA HHFW H-mode plasmas, with f{sub NI} {approx} 0.35, when P{sub RF} {ge} 2.5 MW. These plasmas have little or no edge localized mode (ELM) activity during HHFW heating, a substantial increase in stored energy and a sustained central electron temperature of 5-6 keV. Another focus of NSTX HHFW research is to heat an H-mode generated by 90 keV neutral beam injection (NBI). Improved HHFW coupling to NBI-generated H-modes has resulted in a broad increase in electron temperature profile when HHFW heating is applied. Analysis of a closely matched pair of NBI and HHFW+NBI H-mode plasmas revealed that about half of the antenna power is deposited inside the last closed flux surface (LCFS). Of the power damped inside the LCFS about two-thirds is absorbed directly by electrons and one-third accelerates fast-ions that are mostly promptly lost from the plasma. At longer toroidal launch wavelengths, HHFW+NBI H-mode plasmas can have an RF power flow to the divertor outside the LCFS that significantly reduces RF power deposition to the core. ELMs can also reduce RF power deposition to the core and increase power deposition to the edge. Recent full wave modeling of NSTX HHFW+NBI H-mode plasmas, with the model extended to the vessel wall, predicts a coaxial standing mode between the LCFS and the wall that can have large amplitudes at longer launch wavelengths. These simulation results qualitatively agree with HHFW

  17. Full-wave calculation of fast-wave current drive in tokamaks including kparallel upshifts

    International Nuclear Information System (INIS)

    Jaeger, E.F.; Batchelor, D.B.

    1991-01-01

    Numerical calculations of fast-wave current drive (FWCD) efficiency have generally been of two types: ray tracing or global wave calculations. Ray tracing shows that the projection of the wave number (k parallel) along the magnetic field can vary greatly over a ray trajectory, particularly when the launch point is above or below the equatorial plane. As the wave penetrates toward the center of the plasma, k parallel increases, causing a decrease in the parallel phase speed and a corresponding decrease in the current drive efficiency, γ. But the assumptions of geometrical optics, namely short wavelength and strong single-pass absorption, are not greatly applicable in FWCD scenarios. Eigenmode structure, which is ignored in ray tracing, can play an important role in determining electric field strength and Landau damping rates. In such cases, a full-wave or global solution for the wave fields is desirable. In full-wave calculations such as ORION k parallel appear as a differential operator (rvec B·∇) in the argument of the plasma dispersion function. Since this leads to a differential system of infinite order, such codes of necessity assume k parallel ∼ k var-phi = const, where k var-phi is the toroidal wave number. Thus, it is not possible to correctly include effects of the poloidal magnetic field on k parallel. The problem can be alleviated by expressing the electric field as a superposition of poloidal modes, in which case k parallel is purely algebraic. This paper describes a new full-wave calculation, Poloidal Ion Cyclotron Expansion Solution, which uses poloidal and toroidal mode expansions to solve the wave equation in general flux coordinates. The calculation includes a full solution for E parallel and uses a reduced-order form of the plasma conductivity tensor to eliminate numerical problems associated with resolution of the very short wavelength ion Bernstein wave

  18. Urogenital disease: current medical need and recent advances.

    Science.gov (United States)

    Holoboski, M

    1998-11-01

    The Medicinal Chemistry Division session on Urogenital Disease began with an overview by Dr P-O Andersson (Pharmacia and Upjohn, MI, USA) of current medical need and recent advances in the field. Dr Andersson drew attention to the limited interest that pharmaceutical companies have historically shown in the area of non-malignant diseases of the urogenital tract. Conditions such as bladder overactivity and urinary incontinence, benign prostatic hyperplasia (BPH) and erectile dysfunction have been poorly understood and have been regarded as unavoidable consequences of old age. One factor, which further compounds the problem, is that many people do not seek treatment, a practice which tends to lower the awareness of these conditions.

  19. A DEMO relevant fast wave current drive high harmonic antenna exploiting the high impedance technique

    Energy Technology Data Exchange (ETDEWEB)

    Milanesio, D., E-mail: daniele.milanesio@polito.it; Maggiora, R. [Politecnico di Torino, Dipartimento di Elettronica e Telecomunicazioni (DET), Torino (Italy)

    2015-12-10

    Ion Cyclotron (IC) antennas are routinely adopted in most of the existing nuclear fusion experiments, even though their main goal, i.e. to couple high power to the plasma (MW), is often limited by rather severe drawbacks due to high fields on the antenna itself and on the unmatched part of the feeding lines. In addition to the well exploited auxiliary ion heating during the start-up phase, some non-ohmic current drive (CD) at the IC range of frequencies may be explored in view of the DEMO reactor. In this work, we suggest and describe a compact high frequency DEMO relevant antenna, based on the high impedance surfaces concept. High-impedance surfaces are periodic metallic structures (patches) usually displaced on top of a dielectric substrate and grounded by means of vertical posts embedded inside the dielectric, in a mushroom-like shape. These structures present a high impedance, within a given frequency band, such that the image currents are in-phase with the currents of the antenna itself, thus determining a significant efficiency increase. After a general introduction on the properties of high impedance surfaces, we analyze, by means of numerical codes, a dielectric based and a full metal solution optimized to be tested and benchmarked on the FTU experiment fed with generators at 433MHz.

  20. Advanced Curation of Current and Future Extraterrestrial Samples

    Science.gov (United States)

    Allen, Carlton C.

    2013-01-01

    Curation of extraterrestrial samples is the critical interface between sample return missions and the international research community. Curation includes documentation, preservation, preparation, and distribution of samples. The current collections of extraterrestrial samples include: Lunar rocks / soils collected by the Apollo astronauts Meteorites, including samples of asteroids, the Moon, and Mars "Cosmic dust" (asteroid and comet particles) collected by high-altitude aircraft Solar wind atoms collected by the Genesis spacecraft Comet particles collected by the Stardust spacecraft Interstellar dust collected by the Stardust spacecraft Asteroid particles collected by the Hayabusa spacecraft These samples were formed in environments strikingly different from that on Earth. Terrestrial contamination can destroy much of the scientific significance of many extraterrestrial materials. In order to preserve the research value of these precious samples, contamination must be minimized, understood, and documented. In addition the samples must be preserved - as far as possible - from physical and chemical alteration. In 2011 NASA selected the OSIRIS-REx mission, designed to return samples from the primitive asteroid 1999 RQ36 (Bennu). JAXA will sample C-class asteroid 1999 JU3 with the Hayabusa-2 mission. ESA is considering the near-Earth asteroid sample return mission Marco Polo-R. The Decadal Survey listed the first lander in a Mars sample return campaign as its highest priority flagship-class mission, with sample return from the South Pole-Aitken basin and the surface of a comet among additional top priorities. The latest NASA budget proposal includes a mission to capture a 5-10 m asteroid and return it to the vicinity of the Moon as a target for future sampling. Samples, tools, containers, and contamination witness materials from any of these missions carry unique requirements for acquisition and curation. Some of these requirements represent significant advances over

  1. Evaluation of advanced and current leak detection systems

    International Nuclear Information System (INIS)

    Kupperman, D.S.

    1988-01-01

    U.S. Nuclear Regulatory Commission Guide 1.45 recommends the use of at least three different detection methods in reactors to detect leakage. Monitoring of both sump-flow and airborne particulate radioactivity is mandatory. A third method can involve either monitoring of condensate flow rate from air coolers or monitoring of airborne gaseous radioactivity. Although the methods currently used for leak detection reflect the state of the art, other techniques may be developed and used. Since the recommendations of Regulatory Guide 1.45 are not mandatory, Licensee Event Report Compilations have been reviewed to help establish actual capabilities for leak detection. The review of event reports, which had previously covered the period of June 1985 to August 1986 has been extended, and now covers events to June 1987. The total number of significant events is now 83. These reports have provided documented, sometimes detailed, summaries of reactor leaks. They have helped establish the capabilities of existing systems to detect and locate leaks. Differences between PWRs and BWRs with regard to leak detection have now been analyzed. With regard to detection methods, the greatest differences between reactor types are as follows: (a) The sump pump is reported as the detection method more frequently in BWRs than in PWRs (64% vs. 35%). (b) The radiation monitor is reported as the detection method (excluding false alarms) more frequently in PWRs. Current efforts at Argonne National Laboratory (ANL) to evaluate advanced acoustic leak detection methods are directed toward the generation and analysis of acoustic data from large (0.5 to 10 gal/min) leaks and modification of the software of the GARD/ANL advanced acoustic leak detection system. In order to reach the goal of 10 gal/min leaks, the Steam Generator Test Facility at ANL has been modified to carry out the leak testing. Tests were carried out with water at 525 deg. F and 1100 psi leaking through a fatigue crack in a 4-in

  2. Transportation and Aging: An Updated Research Agenda to Advance Safe Mobility among Older Adults Transitioning From Driving to Non-driving.

    Science.gov (United States)

    Dickerson, Anne E; Molnar, Lisa J; Bédard, Michel; Eby, David W; Berg-Weger, Marla; Choi, Moon; Grigg, Jenai; Horowitz, Amy; Meuser, Thomas; Myers, Anita; O'Connor, Melissa; Silverstein, Nina M

    2017-07-29

    Engagement in civic, social, and community life plays an important role in health, well-being, and quality of life, and requires individuals to be mobile in their environment. In this article, we review what is currently known about 2 areas relevant to safe mobility for older drivers and identify future research in these areas. Using a framework for transportation and safe mobility, 2 key areas were selected for review: the process of transitioning to non-driving and the maintenance of mobility after driving has ceased. This article serves as a companion to another article that used the same approach to explore safe mobility issues for older adults who are still driving. We found that although there has been progress in supporting transitioning process to non-driving and improving mobility options for older adults following driving cessation, many knowledge gaps still exist. We identified several research topics that would benefit from continued scientific inquiry. In addition, several themes emerged from the review, including the need for: multidisciplinary, community-wide solutions; large-scale, longitudinal studies; improved education and training for older adults and the variety of stakeholders involved in older adult transportation; and the need for programs and interventions that are flexible and responsive to individual needs and situational differences. © The Author 2017. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  3. Drugs in development for toxoplasmosis: advances, challenges, and current status

    Directory of Open Access Journals (Sweden)

    Alday PH

    2017-01-01

    Full Text Available P Holland Alday,1 Joseph Stone Doggett1,2 1Division of Infectious Diseases, Oregon Health & Science University, 2Portland Veterans Affairs Medical Center, Portland, OR, USA Abstract: Toxoplasma gondii causes fatal and debilitating brain and eye diseases. Medicines that are currently used to treat toxoplasmosis commonly have toxic side effects and require prolonged courses that range from weeks to more than a year. The need for long treatment durations and the risk of relapsing disease are in part due to the lack of efficacy against T. gondii tissue cysts. The challenges for developing a more effective treatment for toxoplasmosis include decreasing toxicity, achieving therapeutic concentrations in the brain and eye, shortening duration, eliminating tissue cysts from the host, safety in pregnancy, and creating a formulation that is inexpensive and practical for use in resource-poor areas of the world. Over the last decade, significant progress has been made in identifying and developing new compounds for the treatment of toxoplasmosis. Unlike clinically used medicines that were repurposed for toxoplasmosis, these compounds have been optimized for efficacy against toxoplasmosis during preclinical development. Medicines with enhanced efficacy as well as features that address the unique aspects of toxoplasmosis have the potential to greatly improve toxoplasmosis therapy. This review discusses the facets of toxoplasmosis that are pertinent to drug design and the advances, challenges, and current status of preclinical drug research for toxoplasmosis. Keywords: Toxoplasma gondii, therapeutics, preclinical medicine, experimental medicine, mechanism of action, Apicomplexa

  4. Drugs in development for toxoplasmosis: advances, challenges, and current status.

    Science.gov (United States)

    Alday, P Holland; Doggett, Joseph Stone

    2017-01-01

    Toxoplasma gondii causes fatal and debilitating brain and eye diseases. Medicines that are currently used to treat toxoplasmosis commonly have toxic side effects and require prolonged courses that range from weeks to more than a year. The need for long treatment durations and the risk of relapsing disease are in part due to the lack of efficacy against T. gondii tissue cysts. The challenges for developing a more effective treatment for toxoplasmosis include decreasing toxicity, achieving therapeutic concentrations in the brain and eye, shortening duration, eliminating tissue cysts from the host, safety in pregnancy, and creating a formulation that is inexpensive and practical for use in resource-poor areas of the world. Over the last decade, significant progress has been made in identifying and developing new compounds for the treatment of toxoplasmosis. Unlike clinically used medicines that were repurposed for toxoplasmosis, these compounds have been optimized for efficacy against toxoplasmosis during preclinical development. Medicines with enhanced efficacy as well as features that address the unique aspects of toxoplasmosis have the potential to greatly improve toxoplasmosis therapy. This review discusses the facets of toxoplasmosis that are pertinent to drug design and the advances, challenges, and current status of preclinical drug research for toxoplasmosis.

  5. Current Knowledge and Recent Advances in Marine Dinoflagellate Transcriptomic Research

    Directory of Open Access Journals (Sweden)

    Muhamad Afiq Akbar

    2018-02-01

    Full Text Available Dinoflagellates are essential components in marine ecosystems, and they possess two dissimilar flagella to facilitate movement. Dinoflagellates are major components of marine food webs and of extreme importance in balancing the ecosystem energy flux in oceans. They have been reported to be the primary cause of harmful algae bloom (HABs events around the world, causing seafood poisoning and therefore having a direct impact on human health. Interestingly, dinoflagellates in the genus Symbiodinium are major components of coral reef foundations. Knowledge regarding their genes and genome organization is currently limited due to their large genome size and other genetic and cytological characteristics that hinder whole genome sequencing of dinoflagellates. Transcriptomic approaches and genetic analyses have been employed to unravel the physiological and metabolic characteristics of dinoflagellates and their complexity. In this review, we summarize the current knowledge and findings from transcriptomic studies to understand the cell growth, effects on environmental stress, toxin biosynthesis, dynamic of HABs, phylogeny and endosymbiosis of dinoflagellates. With the advancement of high throughput sequencing technologies and lower cost of sequencing, transcriptomic approaches will likely deepen our understanding in other aspects of dinoflagellates’ molecular biology such as gene functional analysis, systems biology and development of model organisms.

  6. The ergodic limit of multipass absorption for fast wave current drive in tokamaks

    Science.gov (United States)

    Kupfer, K.; Forest, C. B.; Petty, C. C.; Pinsker, R. I.

    1994-12-01

    In many parameter regimes of interest for fast wave current drive (FWCD) in tokamaks, direct absorption of the fast wave by resonant electrons is a weak process and multipass absorption is an important issue. Although both full wave codes and ray tracing codes have been developed to model FWCD, in the multipass regime these tools are computationally intensive, and yield little insight into the nature of the solutions. In this work, an alternative approach is considered. Based on the wave kinetic equation, a natural limit emerges for the multipass regime, where wave energy density, convected along stochastic ray trajectories, uniformly fills the entire accessible phase space. In this ergodic, weak damping limit, the absorbed power density and corresponding wave-driven current density are readily obtained by calculating the appropriate set of one-dimensional k-space integrals at every point in configuration space. The method is used here to model FWCD on the DIII-D tokamak [R. I. Pinsker and the DIII-D Team, Plasma Physics and Controlled Nuclear Fusion Research 1992 (International Atomic Energy Agency, Vienna, 1993), Vol. 1, p. 683]. An example for reactor-grade plasma parameters is also considered.

  7. First lower hybrid current drive experiments at 3.7 GHz in Tore Supra

    International Nuclear Information System (INIS)

    Tonon, G.; Goniche, M.; Moreau, D.

    1989-01-01

    The results of electromagnetic waves injection in the Tore Supra plasma, at a frequency of 3.7 GHz, are reported. The process is applied for current generation and plasma heating, through Landau damping on the electron population. The experimental set-up is described. The lower hybrid current drive experiments in Tore Supra are carried out under the following conditions: major and minor radii of the plasma are respectively 2.37 m and 0.77 m and the toroidal magnetic field is 1.8 Teslas. A multijunction-grill composed of 128 waveguides is applied. Up to 1.25 MW of rf power is injected in Tore Supra, after less than 30 plasma shots. The results lead to the conclusion that the coupling, not yet optimized, is good enough for safe klystron operation with no circulator. The measured value RIp P RF -1 (δV L /V L ) obtained on Tore Supra (Bt = 1.8 T) is closed to one observed on PETULA-B (Bt = 2.75 T) at the same frequency and density

  8. RF heating and current drive on NSTX with high harmonic fast waves

    International Nuclear Information System (INIS)

    Ryan, P.M.

    2002-01-01

    NSTX is a small aspect ratio tokamak with a large dielectric constant (50-100); under these conditions high harmonic fast waves (HHFW) will readily damp on electrons via Landau damping and TTMP. The HHFW system is a 30 MHz, 12-element array capable of launching both symmetric and directional wave spectra for plasma heating and non-inductive current drive. It has delivered up to 6 MW for short pulses and has routinely operated at ∼3-4 MW for 100-200 ms pulses. Results include strong, centrally-peaked electron heating in both D and He plasmas, for both high and low phase velocity spectra. H-modes were obtained with application of HHFW power alone, with stored energy doubling after the L-H transition. Beta poloidal as large as unity has been obtained with large fractions (0.4) of bootstrap current. A fast ion tail with energies extending up to 140 keV has been observed when HHFW interacts with 80 keV neutral beams; neutron rate and lost ion measurements, as well as modeling, indicate significant power absorption by the fast ions. Radial power deposition profiles are being calculated with ray tracing and kinetic full-wave codes and benchmarked against measurements. (author)

  9. Current understanding of the driving mechanisms for spatiotemporal variations of atmospheric speciated mercury: a review

    Directory of Open Access Journals (Sweden)

    H. Mao

    2016-10-01

    Full Text Available Atmospheric mercury (Hg is a global pollutant and thought to be the main source of mercury in oceanic and remote terrestrial systems, where it becomes methylated and bioavailable; hence, atmospheric mercury pollution has global consequences for both human and ecosystem health. Understanding of spatial and temporal variations of atmospheric speciated mercury can advance our knowledge of mercury cycling in various environments. This review summarized spatiotemporal variations of total gaseous mercury or gaseous elemental mercury (TGM/GEM, gaseous oxidized mercury (GOM, and particulate-bound mercury (PBM in various environments including oceans, continents, high elevation, the free troposphere, and low to high latitudes. In the marine boundary layer (MBL, the oxidation of GEM was generally thought to drive the diurnal and seasonal variations of TGM/GEM and GOM in most oceanic regions, leading to lower GEM and higher GOM from noon to afternoon and higher GEM during winter and higher GOM during spring–summer. At continental sites, the driving mechanisms of TGM/GEM diurnal patterns included surface and local emissions, boundary layer dynamics, GEM oxidation, and for high-elevation sites mountain–valley winds, while oxidation of GEM and entrainment of free tropospheric air appeared to control the diurnal patterns of GOM. No pronounced diurnal variation was found for Tekran measured PBM at MBL and continental sites. Seasonal variations in TGM/GEM at continental sites were attributed to increased winter combustion and summertime surface emissions, and monsoons in Asia, while those in GOM were controlled by GEM oxidation, free tropospheric transport, anthropogenic emissions, and wet deposition. Increased PBM at continental sites during winter was primarily due to local/regional coal and wood combustion emissions. Long-term TGM measurements from the MBL and continental sites indicated an overall declining trend. Limited measurements suggested TGM

  10. Advanced Curation: Solving Current and Future Sample Return Problems

    Science.gov (United States)

    Fries, M.; Calaway, M.; Evans, C.; McCubbin, F.

    2015-01-01

    Advanced Curation is a wide-ranging and comprehensive research and development effort at NASA Johnson Space Center that identifies and remediates sample related issues. For current collections, Advanced Curation investigates new cleaning, verification, and analytical techniques to assess their suitability for improving curation processes. Specific needs are also assessed for future sample return missions. For each need, a written plan is drawn up to achieve the requirement. The plan draws while upon current Curation practices, input from Curators, the analytical expertise of the Astromaterials Research and Exploration Science (ARES) team, and suitable standards maintained by ISO, IEST, NIST and other institutions. Additionally, new technologies are adopted on the bases of need and availability. Implementation plans are tested using customized trial programs with statistically robust courses of measurement, and are iterated if necessary until an implementable protocol is established. Upcoming and potential NASA missions such as OSIRIS-REx, the Asteroid Retrieval Mission (ARM), sample return missions in the New Frontiers program, and Mars sample return (MSR) all feature new difficulties and specialized sample handling requirements. The Mars 2020 mission in particular poses a suite of challenges since the mission will cache martian samples for possible return to Earth. In anticipation of future MSR, the following problems are among those under investigation: What is the most efficient means to achieve the less than 1.0 ng/sq cm total organic carbon (TOC) cleanliness required for all sample handling hardware? How do we maintain and verify cleanliness at this level? The Mars 2020 Organic Contamination Panel (OCP) predicts that organic carbon, if present, will be present at the "one to tens" of ppb level in martian near-surface samples. The same samples will likely contain wt% perchlorate salts, or approximately 1,000,000x as much perchlorate oxidizer as organic carbon

  11. The payloads of Advanced Virgo: current status and upgrades

    Science.gov (United States)

    Naticchioni, L.; Virgo Collaboration

    2018-02-01

    The development and integration of new detector payloads has been an important part of the Advanced Virgo (AdV) project, the major upgrade of the Virgo interferometric detector of Gravitational Waves, aiming to increase the detector sensitivity by one order of magnitude. During the integration phase of the new AdV payloads with monolithic suspension of mirrors we experienced systematic suspension failures later identified as caused by dust contamination of the vacuum system. In order to not postpone the detector commissioning, making possible to join the LIGO O2 observation run, the Collaboration decided to proceed with the integration of the payloads relying on steel wire suspensions for all the mirrors. In this proceeding the status of the currently integrated payloads is reported, including their angular control characterization and the Q-factor measurements for test mass steel wire suspensions. The payload upgrade for the re-integration of monolithic suspensions after the O2 run is reported in the last section.

  12. Current advances in precious metal core–shell catalyst design

    Science.gov (United States)

    Wang, Xiaohong; He, Beibei; Hu, Zhiyu; Zeng, Zhigang; Han, Sheng

    2014-01-01

    Precious metal nanoparticles are commonly used as the main active components of various catalysts. Given their high cost, limited quantity, and easy loss of catalytic activity under severe conditions, precious metals should be used in catalysts at low volumes and be protected from damaging environments. Accordingly, reducing the amount of precious metals without compromising their catalytic performance is difficult, particularly under challenging conditions. As multifunctional materials, core–shell nanoparticles are highly important owing to their wide range of applications in chemistry, physics, biology, and environmental areas. Compared with their single-component counterparts and other composites, core–shell nanoparticles offer a new active interface and a potential synergistic effect between the core and shell, making these materials highly attractive in catalytic application. On one hand, when a precious metal is used as the shell material, the catalytic activity can be greatly improved because of the increased surface area and the closed interfacial interaction between the core and the shell. On the other hand, when a precious metal is applied as the core material, the catalytic stability can be remarkably improved because of the protection conferred by the shell material. Therefore, a reasonable design of the core–shell catalyst for target applications must be developed. We summarize the latest advances in the fabrications, properties, and applications of core–shell nanoparticles in this paper. The current research trends of these core–shell catalysts are also highlighted. PMID:27877695

  13. Proposed high voltage power supply for the ITER relevant lower hybrid current drive system

    International Nuclear Information System (INIS)

    Sharma, P.K.; Kazarian, F.; Garibaldi, P.; Gassman, T.; Artaud, J.F.; Bae, Y.S.; Belo, J.; Berger-By, G.; Bernard, J.M.; Cara, Ph.; Cardinali, A.; Castaldo, C.; Ceccuzzi, S.; Cesario, R.; Decker, J.; Delpech, L.; Ekedahl, A.; Garcia, J.; Goniche, M.; Guilhem, D.

    2011-01-01

    In the framework of the EFDA task HCD-08-03-01, the ITER lower hybrid current drive (LHCD) system design has been reviewed. The system aims to generate 24 MW of RF power at 5 GHz, of which 20 MW would be coupled to the plasmas. The present state of the art does not allow envisaging a unitary output of the klystrons exceeding 500 kW, so the project is based on 48 klystron units, leaving some margin when the transmission lines losses are taken into account. A high voltage power supply (HVPS), required to operate the klystrons, is proposed. A single HVPS would be used to feed and operate four klystrons in parallel configuration. Based on the above considerations, it is proposed to design and develop twelve HVPS, based on pulse step modulator (PSM) technology, each rated for 90 kV/90 A. This paper describes in details, the typical electrical requirements and the conceptual design of the proposed HVPS for the ITER LHCD system.

  14. Two-dimensional analysis of beat wave current drive with intense microwave pulses

    International Nuclear Information System (INIS)

    Amin, M.R.; Cairns, R.A.

    1990-01-01

    Current drive in tokamak plasmas by a beat wave is considered in two-dimensional (2-D) geometry. The beat wave is excited by the non-linear interaction of two intense microwave pulses (free electron lasers) in the plasma. The three-wave non-linear interaction equations in steady state are solved numerically. The 2-D toroidal effect and the effect of finite spatial width of the pump microwave pulses are taken into account for the excitation of the beat mode. To illustrate the principle, two types of tokamak are considered: one is small, such as, typically, the Microwave Tokamak Experiment (MTX). and the other one is larger, such as the Joint European Torus (JET). In both cases, it is found that good beat wave coupling exists for a Langmuir beat wave with a phase velocity of around 2.0 to 4.0 times the thermal velocity of the electrons. The fraction of total input power of the right circularly polarized pump waves deposited in the beat mode can be as high as 29% in JET and 32% in MTX. In these cases, there is almost complete pump depletion of the higher frequency pump microwave. It is also found that, for the same input parameters, left circularly polarized pump waves are less efficient than right circularly polarized pump waves for depositing power in the beat mode. (author). 12 refs, 15 figs, 5 tabs

  15. Advanced Research and Education in Electrical Drives by Using Digital Real-Time Hardware-in-the-Loop Simulation

    DEFF Research Database (Denmark)

    Bojoi, R.; Profumo, F.; Griva, G.

    2002-01-01

    The authors present in this paper a digital real-time hardware-in-the-loop simulation of a three-phase induction motor drive. The main real-time simulation tool is the dSPACE DS1103 PPC Controller Board which simulates the power and signal conditioning parts. The control algorithm of the virtual...... drive has been implemented on the Evaluation Board of TMS320F240 DSP. The experimental results validate this solution as a powerful tool to be used in research and advanced education. Thus, the students can put in practic the theory without spending too much time with details concerning the hardware...

  16. Active load current sharing in fuel cell and battery fed DC motor drive for electric vehicle application

    International Nuclear Information System (INIS)

    Pany, Premananda; Singh, R.K.; Tripathi, R.K.

    2016-01-01

    Highlights: • Load current sharing in FC and battery fed dc drive. • Active current sharing control using LabVIEW. • Detail hardware implementation. • Controller performance is verified through MATLAB simulation and experimental results. - Abstract: In order to reduce the stress on fuel cell based hybrid source fed electric drive system the controller design is made through active current sharing (ACS) technique. The effectiveness of the proposed ACS technique is tested on a dc drive system fed from fuel cell and battery energy sources which enables both load current sharing and source power management. High efficiency and reliability of the hybrid system can be achieved by proper energy conversion and management of power to meet the load demand in terms of required voltage and current. To overcome the slow dynamics feature of FC, a battery bank of adequate power capacity has to be incorporated as FC voltage drops heavily during fast load demand. The controller allows fuel cell to operate in normal load region and draw the excess power from battery. In order to demonstrate the performance of the drive using ACS control strategy different modes of operation of the hybrid source with the static and dynamic behavior of the control system is verified through simulation and experimental results. This control scheme is implemented digitally in LabVIEW with PCI 6251 DAQ I/O interface card. The efficacy of the controller performance is demonstrated in system changing condition supplemented by experimental validation.

  17. Current Advances in Detection and Treatment of Babesiosis

    Science.gov (United States)

    Mosqueda, J; Olvera-Ramírez, A; Aguilar-Tipacamú, G; Cantó, GJ

    2012-01-01

    Babesiosis is a disease with a world-wide distribution affecting many species of mammals principally cattle and man. The major impact occurs in the cattle industry where bovine babesiosis has had a huge economic effect due to loss of meat and beef production of infected animals and death. Nowadays to those costs there must be added the high cost of tick control, disease detection, prevention and treatment. In almost a century and a quarter since the first report of the disease, the truth is: there is no a safe and efficient vaccine available, there are limited chemotherapeutic choices and few low-cost, reliable and fast detection methods. Detection and treatment of babesiosis are important tools to control babesiosis. Microscopy detection methods are still the cheapest and fastest methods used to identify Babesia parasites although their sensitivity and specificity are limited. Newer immunological methods are being developed and they offer faster, more sensitive and more specific options to conventional methods, although the direct immunological diagnoses of parasite antigens in host tissues are still missing. Detection methods based on nucleic acid identification and their amplification are the most sensitive and reliable techniques available today; importantly, most of those methodologies were developed before the genomics and bioinformatics era, which leaves ample room for optimization. For years, babesiosis treatment has been based on the use of very few drugs like imidocarb or diminazene aceturate. Recently, several pharmacological compounds were developed and evaluated, offering new options to control the disease. With the complete sequence of the Babesia bovis genome and the B. bigemina genome project in progress, the post-genomic era brings a new light on the development of diagnosis methods and new chemotherapy targets. In this review, we will present the current advances in detection and treatment of babesiosis in cattle and other animals, with additional

  18. Prospects for stabilization of neoclassical tearing modes by electron cyclotron current drive in ITER

    International Nuclear Information System (INIS)

    La Haye, R.J.; Isayama, A.; Maraschek, M.

    2009-01-01

    The system planned for electron cyclotron current drive (ECCD) in ITER can mitigate the deleterious effects of neoclassical tearing modes (NTMs) provided that either adequate alignment of the ECCD to the rational surface is maintained or too large a misalignment is corrected on a time scale shorter than the deleterious plasma response to 'large' islands. Resistive neoclassical tearing modes will be the principal limit on stability and performance in the ITER standard scenario as the drag from rotating island induced eddy current in the resistive wall (particularly from the m/n = 2/1 mode) can slow the plasma rotation, produce locking to the wall and cause loss of high-confinement H-mode and disruption. Continuous wave (cw) ECCD at the island rational surface is successful in stabilization and/or prevention of NTMs in ASDEX Upgrade, DIII-D and JT-60U. Modulating the ECCD so that it is absorbed only on the rotating island O-point is proving successful in recovering effectiveness in ASDEX Upgrade when the ECCD is configured for wider deposition as expected in ITER. The models for the effect of misalignment on ECCD effectiveness are applied to ITER. Tolerances for misalignment are presented to establish criteria for both the alignment (by moving mirrors in ITER) in the presence of an island, and for the accuracy of real-time ITER MHD equilibrium reconstruction in the absence of an island, i.e. alignment to the mode or to the rational surface in the absence of the mode. The narrower ECCD with front steering makes precise alignment more necessary for the most effective stabilization even though the ECCD is still relatively broad, with current density deposition (full width half maximum) almost twice the marginal island width. This places strict requirements on ECCD alignment with the expected ECCD effectiveness dropping to zero for misalignments as small as 1.7 cm. The system response time for growing islands and slowing rotation without and with ECCD (at different

  19. Behavioral reactions to advanced cruise control: results of a driving simulator experiment

    NARCIS (Netherlands)

    Hoedemaeker, D.M.

    2000-01-01

    This chapter describes an experimental study that is conducted in the driving simulator at the Centre for Environmental and Traffic Psychology (COV) of the University of Groningen. In the experiment, two groups of drivers, who differed with respect to reported driving style in terms of speed, drove

  20. Advanced Direct-Drive Generator for Improved Availability of Oscillating Wave Surge Converter Power Generation Systems Final Technical Report

    Energy Technology Data Exchange (ETDEWEB)

    Englebretson, Steven [ABB Inc., Cary, NC (United States); Ouyang, Wen [ABB Inc., Cary, NC (United States); Tschida, Colin [ABB Inc., Cary, NC (United States); Carr, Joseph [ABB Inc., Cary, NC (United States); Ramanan, V.R. [ABB Inc., Cary, NC (United States); Johnson, Matthew [Texas A& M Univ., College Station, TX (United States); Gardner, Matthew [Texas A& M Univ., College Station, TX (United States); Toliyat, Hamid [Texas A& M Univ., College Station, TX (United States); Staby, Bill [Resolute Marine Energy, Inc., Boston, MA (United States); Chertok, Allan [Resolute Marine Energy, Inc., Boston, MA (United States); Hazra, Samir [ABB Inc., Cary, NC (United States); Bhattacharya, Subhashish [ABB Inc., Cary, NC (United States)

    2017-05-13

    This report summarizes the activities conducted under the DOE-EERE funded project DE-EE0006400, where ABB Inc. (ABB), in collaboration with Texas A&M’s Advanced Electric Machines & Power Electronics (EMPE) Lab and Resolute Marine Energy (RME) designed, derisked, developed, and demonstrated a novel magnetically geared electrical generator for direct-drive, low-speed, high torque MHK applications The project objective was to investigate a novel and compact direct-drive electric generator and its system aspects that would enable elimination of hydraulic components in the Power Take-Off (PTO) of a Marine and Hydrokinetic (MHK) system with an oscillating wave surge converter (OWSC), thereby improving the availability of the MHK system. The scope of this project was limited to the development and dry lab demonstration of a low speed generator to enable future direct drive MHK systems.

  1. Advanced robotics for medical rehabilitation current state of the art and recent advances

    CERN Document Server

    Xie, Shane

    2016-01-01

    Focussing on the key technologies in developing robots for a wide range of medical rehabilitation activities – which will include robotics basics, modelling and control, biomechanics modelling, rehabilitation strategies, robot assistance, clinical setup/implementation as well as neural and muscular interfaces for rehabilitation robot control – this book is split into two parts; a review of the current state of the art, and recent advances in robotics for medical rehabilitation. Both parts will include five sections for the five key areas in rehabilitation robotics: (i) the upper limb; (ii) lower limb for gait rehabilitation (iii) hand, finger and wrist; (iv) ankle for strains and sprains; and (v) the use of EEG and EMG to create interfaces between the neurological and muscular functions of the patients and the rehabilitation robots. Each chapter provides a description of the design of the device, the control system used, and the implementation and testing to show how it fulfils the needs of that specific ...

  2. Evolution of the Tore Supra Lower Hybrid Current Drive System for WEST

    Energy Technology Data Exchange (ETDEWEB)

    Delpech, Léna, E-mail: lena.delpech@cea.fr [CEA, IRFM, F-13108 St Paul-Lez-Durance (France); Achard, Joelle; Armitano, Arthur; Berger-By, Gilles; Ekedahl, Annika; Gargiulo, Laurent; Goniche, Marc; Guilhem, Dominique; Hertout, Patrick; Hillairet, Julien; Magne, Roland; Mollard, Patrick [CEA, IRFM, F-13108 St Paul-Lez-Durance (France); Piluso, P. [CNIM Industrial Systems, 83507 La Seyne-sur-Mer (France); Poli, Serge; Prou, Marc; Saille, Alain; Samaille, Franck [CEA, IRFM, F-13108 St Paul-Lez-Durance (France)

    2015-10-15

    Highlights: • Describe the state of the Lower Hybrid heating system for the WEST project. • Detailed the experiments to assess the coupling in WEST configuration. • Give the modifications required on the launchers to be adapted to WEST configuration. • Detailed the technical modifications with the CNIM company on the launchers. - Abstract: The WEST-project (W-tungsten Environment in Steady-state Tokamak) involves equipping Tore Supra with a full tungsten divertor, capable of withstanding heat load of 10 MW/m{sup 2} in steady-state conditions, in discharges sustained by Lower Hybrid Current Drive (LHCD). The LHCD generator, recently upgraded to deliver 9.2 MW/1000 s, is equipped with sixteen TH2103C klystrons powering two launchers. The WEST transformation involves reducing the plasma volume, thus moving the launchers ∼10 cm closer to the tokamak centre. The toroidal curvature of the launchers no longer fits the plasma curvature due to the strong magnetic field ripple effect, leading to a degradation of the LH wave coupling, especially with the Full Active Multijunction Launcher (FAM). The toroidal curvature radius of the FAM launcher mouth will therefore be reshaped from 1700 mm to 2300 mm. The machining process is described in this article. In order to improve the coupling of the LH wave, the local gas injection has been modified to help to meet the requirement of 7 MW/1000 s of LH power coupled to the plasma in the WEST scenarios. Finally, the curvature radius of the waveguide septa are rounded to minimize the excitation of suprathermal electrons near the plasma edge, which can induce high power loads on the plasma facing components.

  3. Advances in Modeling Direct-Drive Ignition at the National Ignition Facility

    Science.gov (United States)

    Collins, T. J. B.; Marozas, J. A.

    2017-10-01

    Polar direct drive (PDD) makes it possible to perform direct-drive-ignition experiments at the National Ignition Facility (NIF) while the facility is configured for indirect drive. We present for the first time PDD ignition-relevant target designs with decreased laser intensities. These designs include the physical effects of cross-beam energy transfer (CBET) and nonlocal heat transport, both of which substantially affect the target drive. In the PDD configuration, a multiwavelength detuning strategy was found to be effective in mitigating the loss of coupling caused by CBET, allowing for implosion speeds comparable to those of previous designs. Target designs will be presented that span the region from alpha-particle heating to ignition. In addition, ignition-relevant designs will also be discussed for use in symmetric direct drive on the NIF. This material is based upon work supported by the Department of Energy National Nuclear Security Administration under Award Number DE-NA0001944.

  4. MADD rates the states: a media advocacy event to advance the agenda against alcohol-impaired driving.

    Science.gov (United States)

    Russell, A; Voas, R B; Dejong, W; Chaloupka, M

    1995-01-01

    The "Rating the States" (RTS) Program of Mothers Against Drunk Driving (MADD) is designed to bring public attention to the status of State government efforts to combat alcohol-impaired driving. MADD's 1993 report, which evaluated each State with a grade from A to D, brought renewed visibility to MADD's fight for new prevention policies and helped to advance key State legislation. Because of MADD's national press conference and other media activities, more than 60 million Americans saw or heard a news story related to the program. This article outlines the program's objectives and methodology, efforts to publicize the results, and what was achieved in terms of news media coverage and in advancing public policy change. The RTS Program is a proven media advocacy strategy for prompting State legislatures and Governors to enact new policies. The article concludes with guidelines for other public health advocacy groups that may want to emulate this strategy.

  5. Analysis and Suppression of Zero Sequence Circulating Current in Open Winding PMSM Drives With Common DC Bus

    OpenAIRE

    Zhan, H.; Zhu, Z.Q.; Odavic, M.

    2017-01-01

    In this paper, the zero sequence circulating current in open winding permanent magnet synchronous machine (OW-PMSM) drives with common dc bus is systematically analyzed for the first time. It is revealed that the zero sequence circulating current is affected by zero sequence back-electromotive force, cross coupling voltages in zero sequence from the machine side, pulse-width modulation induced zero sequence voltage, and inverter nonlinearity from the inverter side. Particularly, the influence...

  6. The role of specific visual subfields in collisions with oncoming cars during simulated driving in patients with advanced glaucoma.

    Science.gov (United States)

    Kunimatsu-Sanuki, Shiho; Iwase, Aiko; Araie, Makoto; Aoki, Yuki; Hara, Takeshi; Fukuchi, Takeo; Udagawa, Sachiko; Ohkubo, Shinji; Sugiyama, Kazuhisa; Matsumoto, Chota; Nakazawa, Toru; Yamaguchi, Takuhiro; Ono, Hiroshi

    2017-07-01

    To assess the role of specific visual subfields in collisions with oncoming cars during simulated driving in patients with advanced glaucoma. Normal subjects and patients with glaucoma with mean deviation glaucoma. And, 5 of the 100 patients with advanced glaucoma experienced simulator sickness during the main test and were thus excluded. In total, 95 patients with advanced glaucoma and 43 normal subjects completed the main test of DS. Advanced glaucoma patients had significantly more collisions than normal patients in one or both DS scenarios (pglaucoma who were involved in collisions were older (p=0.050) and had worse visual acuity in the better eye (pglaucoma. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/.

  7. Technological advances in perioperative monitoring: Current concepts and clinical perspectives.

    Science.gov (United States)

    Chilkoti, Geetanjali; Wadhwa, Rachna; Saxena, Ashok Kumar

    2015-01-01

    Minimal mandatory monitoring in the perioperative period recommended by Association of Anesthetists of Great Britain and Ireland and American Society of Anesthesiologists are universally acknowledged and has become an integral part of the anesthesia practice. The technologies in perioperative monitoring have advanced, and the availability and clinical applications have multiplied exponentially. Newer monitoring techniques include depth of anesthesia monitoring, goal-directed fluid therapy, transesophageal echocardiography, advanced neurological monitoring, improved alarm system and technological advancement in objective pain assessment. Various factors that need to be considered with the use of improved monitoring techniques are their validation data, patient outcome, safety profile, cost-effectiveness, awareness of the possible adverse events, knowledge of technical principle and ability of the convenient routine handling. In this review, we will discuss the new monitoring techniques in anesthesia, their advantages, deficiencies, limitations, their comparison to the conventional methods and their effect on patient outcome, if any.

  8. Current status and prospect of therapy with advanced cancer

    International Nuclear Information System (INIS)

    Watari, Tsutomu

    1979-01-01

    Symtomatic or palliative therapy of the patients with advanced cancer must be directed to the relief of specific distressing symptoms caused by or associated with neoplasm. The radiotherapy must have a clear concepts of the potential accomplishments of other treatment modalities, such as neurosurgery, anesthesiology, chemotherapy, pharmacology and psychotherapy, so that he may use his own method in proper perspective. I discussed following is an list of contents in this papers. Relief of pain, Psychotherapy, SVC obstruction, Obstructive jaundice, Brain and lung metastasis, prevention of fracture, Skin metastasis, Liver metastasis and treatment of advanced pediaric tumor etc. For the future: 1) Establishment of Stage and Grade of advanced cancer. 2) Development of new chemotherapeutic drug and immunotherapy. 3) Combination of multidisciplinary team and multidisciplinary treatment. (author)

  9. When do we think it is Safe to Drive after Hand Surgery? – Current Practice and Legal Perspective

    LENUS (Irish Health Repository)

    Murphy, SF

    2016-11-01

    Patients recovering from hand surgery frequently ask when it is safe to drive and it is unclear where the responsibility lies; the surgeon, the patient or the insurance company. An eight-question survey looking at various aspects of clinical practice was circulated to consultant and trainee plastic and orthopaedic surgeons in Ireland and the UK. Of the 89 surgeons who replied, (53%) felt the decision when to drive was the patient’s compared with the insurance company (40%) and the surgeon (7%). 80% advised patients to contact their insurance company. 87% were unaware of current regulations or guidelines. National guidelines were vague and left the decision with the treating doctor. Similarly, major insurers advise patients to contact their doctor for advice. From a legal standpoint, the patient has a duty of care to other road users to be in full control of his vehicle prior to driving, regardless of any advice received.

  10. Study of lower hybrid current drive system in tokamak fusion devices

    Energy Technology Data Exchange (ETDEWEB)

    Maebara, Sunao [Japan Atomic Energy Research Inst., Tokai, Ibaraki (Japan). Tokai Research Establishment

    2001-01-01

    This report describes R and D of a high-power klystron, RF vacuum window, low-outgassing antenna and a front module for a plasma-facing antenna aiming the 5 GHz Lower Hybrid Current Drive (LHCD) system for the next Tokamak Fusion Device. 5 GHz klystron with a low-perveances of 0.7 {mu}P is designed for a high-power and a high-efficiency, the output-power of 715 kW and the efficiency of 63%, which are beyond the conventional design scaling of 450 kW-45%, are performed using the prototype klystron which operates at the pulse duration of 15 {mu}sec. A new pillbox window, which has an oversized length in both the axial and the radial direction, are designed to reduce the RF power density and the electric field strength at the ceramics. It is evaluated that the power capability by cooling edge of ceramics is 1 MW with continuous-wave operation. The antenna module using Dispersion Strengthened Copper which combines high mechanical property up to 500degC with high thermal conductivity, are developed for a low-outgassing antenna in a steady state operation. It is found that the outgassing rate is in the lower range of 4x10{sup -6} Pam{sup 3}/sm{sup 2} at the module temperature of 300degC, which requires no active vacuum pumping of the LHCD antenna. A front module using Carbon Fiber Composite (CFC) are fabricated and tested for a plasma facing antenna which has a high heat-resistive. Stationary operation of the CFC module with water cooling is performed at the RF power of 46 MWm{sup -2} (about 2 times higher than the design value) during 1000 sec, it is found that the outgassing rate is less than 10{sup -5} Pam{sup 3}/sm{sup 2} which is low enough for an antenna material. (author)

  11. Gate length scaling trends of drive current enhancement in CMOSFETs with dual stress overlayers and embedded-SiGe

    International Nuclear Information System (INIS)

    Flachowsky, S.; Wei, A.; Herrmann, T.; Illgen, R.; Horstmann, M.; Richter, R.; Salz, H.; Klix, W.; Stenzel, R.

    2008-01-01

    Strain engineering in MOSFETs using tensile nitride overlayer (TOL) films, compressive nitride overlayer (COL) films, and embedded-SiGe (eSiGe) is studied by extensive device experiments and numerical simulations. The scaling behavior was analyzed by gate length reduction down to 40 nm and it was found that drive current strongly depends on the device dimensions. The reduction of drain-current enhancement for short-channel devices can be attributed to two competing factors: shorter gate length devices have increased longitudinal and vertical stress components which should result in improved drain-currents. However, there is a larger degradation from external resistance as the gate length decreases, due to a larger voltage dropped across the external resistance. Adding an eSiGe stressor reduces the external resistance in the p-MOSFET, to the extent that the drive current improvement from COL continues to increase even down the shortest gate length studied. This is due to the reduced resistivity of SiGe itself and the SiGe valence band offset relative to Si, leading to a smaller silicide-active contact resistance. It demonstrates the advantage of combining eSiGe and COL, not only for increased stress, but also for parasitic resistance reduction to enable better COL drive current benefit

  12. The Effects of Transcranial Direct Current Stimulation (tDCS on Psychomotor and Visual Perception Functions Related to Driving Skills

    Directory of Open Access Journals (Sweden)

    Alexander Brunnauer

    2018-01-01

    Full Text Available Objective: It could be demonstrated that anodal transcranial direct current stimulation (tDCS of the left dorsolateral prefrontal cortex (DLPFC enhances accuracy in working memory tasks and reaction time in healthy adults and thus may also have an influence on complex everyday tasks like driving a car. However, no studies have applied tDCS to psychomotor skills related to a standard driving test so far.Methods: 10 female and 5 male healthy adults without any medication and history of psychiatric or neurological illness were randomly assigned to two groups receiving active and sham stimulation in a double blind, cross-over study design. Standardized computerized psychomotor tests according to the German guidelines for road and traffic safety were administered at baseline. Then they performed the same tests during an anodal or sham tDCS of the left DLPFC in two separated sessions.Results: No significant improvements in skills related to driving performance like visual perception, stress tolerance, concentration, and vigilance could be shown after left anodal prefrontal tDCS. Side effects were low and did not differ between active and sham stimulation.Conclusions: The findings of our study indicate that left prefrontal tDCS may not alter driving skills affording more automated action patterns but as shown in previous studies may have an influence on driving behavior requiring executive control processes. This however has to be proved in future studies and within greater samples.

  13. Compact ASD Topologies for Single-Phase Integrated Motor Drives with Sinusoidal Input Current

    DEFF Research Database (Denmark)

    Klumpner, Christian; Blaabjerg, Frede; Thoegersen, Paul

    2005-01-01

    A standard configuration of an Adjustable Speed Drive (ASD) consists of two separate units: an AC motor, which runs with fixed speed when it is supplied from a constant frequency grid voltage and a frequency converter, which is used to provide the motor with variable voltage-variable frequency ne...

  14. Input current interharmonics in adjustable speed drives caused by fixed-frequency modulation techniques

    DEFF Research Database (Denmark)

    Soltani, Hamid; Davari, Pooya; Loh, Poh Chiang

    2016-01-01

    Adjustable Speed Drives (ASDs) based on double-stage conversion systems may inject interharmonics distortion into the grid, other than the well-known characteristic harmonic components. The problems created by interharmonics make it necessary to find their precise sources, and, to adopt an approp...

  15. Recent Advances and Current Trends in Metamaterial-by-Design

    Science.gov (United States)

    Anselmi, N.; Gottardi, G.

    2018-02-01

    Thanks to their potential applications in several engineering areas, metamaterials gained much of attentions among different research communities, leading to the development of several analysis and synthesis tools. In this context, the metamaterial-by-design (MbD) paradigm has been recently introduced as a powerful tool for the design of complex metamaterials-based structures. In this work a review of the state-of-art, as well as the recent advancements of MbD-based methods are presented.

  16. Cancer and Radiation Therapy: Current Advances and Future Directions

    Science.gov (United States)

    Baskar, Rajamanickam; Lee, Kuo Ann; Yeo, Richard; Yeoh, Kheng-Wei

    2012-01-01

    In recent years remarkable progress has been made towards the understanding of proposed hallmarks of cancer development and treatment. However with its increasing incidence, the clinical management of cancer continues to be a challenge for the 21st century. Treatment modalities comprise of radiation therapy, surgery, chemotherapy, immunotherapy and hormonal therapy. Radiation therapy remains an important component of cancer treatment with approximately 50% of all cancer patients receiving radiation therapy during their course of illness; it contributes towards 40% of curative treatment for cancer. The main goal of radiation therapy is to deprive cancer cells of their multiplication (cell division) potential. Celebrating a century of advances since Marie Curie won her second Nobel Prize for her research into radium, 2011 has been designated the Year of Radiation therapy in the UK. Over the last 100 years, ongoing advances in the techniques of radiation treatment and progress made in understanding the biology of cancer cell responses to radiation will endeavor to increase the survival and reduce treatment side effects for cancer patients. In this review, principles, application and advances in radiation therapy with their biological end points are discussed. PMID:22408567

  17. Advanced fuel technology and performance: Current status and trends

    International Nuclear Information System (INIS)

    1990-11-01

    During the last years the Nuclear Fuel Cycle and Waste Management Division of the IAEA has been giving great attention to the collection, analysis and exchange of information in the field of reactor fuel technology. Most of these activities are being conducted in the framework of the International Working Group on Water Reactor Fuel Performance and Technology (IWGFPT). The purpose of this Advisory Group Meeting on Advanced Fuel Technology and Performance was to update and to continue the previous work, and to review the experience of advanced fuel technology, its performance with regard to all types of reactors and to outline the future trends on the basis of national experience and discussions during the meeting. As a result of the meeting a Summary Report was prepared which reflected the status of the advanced nuclear fuel technology up to 1990. The 10 papers presented by participants of this meeting are also published here. A separate abstract was prepared for each of these papers. Refs, figs and tabs

  18. Nonthermal particle and full-wave diffraction effects on heating and current drive in the ICRF and LHRF regimes

    International Nuclear Information System (INIS)

    Wright, J.C.; Bonoli, P.T.; Berry, L.A.; Batchelor, D.B.; Jaeger, E.F.; Carter, M.D.; D'Azevedo, E.; Phillips, C.K.; Okuda, H.; Harvey, R.W.; Smithe, D.N.; Myra, J.R.; D'Ippolito, D.A.; Brambilla, M.; Dumont, R.J.

    2005-01-01

    Fast waves (FW) are a primary technique for heating and current drive (CD) on the proposed burning plasma device, ITER, and lower hybrid (LH) waves are a candidate for edge current profile control. The models used to simulate these two waves rely on assumptions of Maxwellian populations that allow efficient analytic implementations of the plasma response, and in the case of the LH wave, the ray tracing models used are able to follow the very small wavelengths in a continuum manner without requiring a fine computational grid. Recent advances in algorithms and parallel computational methods have allowed these assumptions to be tested, permitting more accurate estimates of heating deposition and CD efficiencies in a burning plasma. Absorption by energetic particles for both waves can be significant, reducing electron heating and associated CD. Wave propagation and absorption is dependent on the velocity space distribution of particles in the plasma and on the geometric effects of focusing and diffraction. Fusion born alpha particles and neutral beam ions may interact with these waves in a manner that cannot be accurately modeled by Maxwellian distributions. The AORSA2D code has been modified to use a generalized non-Maxwellian conductivity, and has been applied to ITER reference scenarios. Preliminary analysis for ITER suggests that alpha absorption may be limited to a few tens of percent, and thus, allow reasonable CD efficiencies, assuming that the RF does not significantly alter the alpha slowing-down distribution. We also discuss the interaction of an energetic Tritium tail with FW in ITER. In addition, the effects of diffraction on LH waves in toroidal geometry are not well understood because computational limits have prohibited full-wave simulations at those small wavelengths. Simulations of LH waves have been restricted to WKB ray tracing techniques and 1D full-wave in the past, but the availability of massively parallel architectures have made full

  19. Advanced Microsystems for Automotive Applications 2015 : Smart Systems for Green and Automated Driving

    CERN Document Server

    Müller, Beate; Meyer, Gereon

    2016-01-01

    This edited volume presents the proceedings of the AMAA 2015 conference, Berlin, Germany. The topical focus of the 2015 conference lies on smart systems for green and automated driving. The automobile of the future has to respond to two major trends, the electrification of the drivetrain, and the automation of the transportation system. These trends will not only lead to greener and safer driving but re-define the concept of the car completely, particularly if they interact with each other in a synergetic way as for autonomous parking and charging, self-driving shuttles or mobile robots. Key functionalities like environment perception are enabled by electronic components and systems, sensors and actuators, communication nodes, cognitive systems and smart systems integration. The book will be a valuable read for research experts and professionals in the automotive industry but the book may also be beneficial for graduate students.

  20. Drive-train dynamics technology - State-of-the-art and design of a test facility for advanced development

    Science.gov (United States)

    Badgley, R. H.; Fleming, D. P.; Smalley, A. J.

    1975-01-01

    A program for the development and verification of drive-train dynamic technology is described along with its basis and the results expected from it. A central feature of this program is a drive-train test facility designed for the testing and development of advanced drive-train components, including shaft systems, dampers, and couplings. Previous efforts in designing flexible dynamic drive-train systems are reviewed, and the present state of the art is briefly summarized. The design of the test facility is discussed with major attention given to the formulation of the test-rig concept, dynamic scaling of model shafts, and the specification of design parameters. Specific efforts envisioned for the test facility are briefly noted, including evaluations of supercritical test shafts, stability thresholds for various sources and types of instabilities that can exist in shaft systems, effects of structural flexibility on the dynamic performance of dampers, and methods for vibration control in two-level and three-level flexible shaft systems.

  1. A Soft-Switching Inverter for High-Temperature Advanced Hybrid Electric Vehicle Traction Motor Drives

    Energy Technology Data Exchange (ETDEWEB)

    Lai, Jason [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Yu, Wensong [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Sun, Pengwei [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Leslie, Scott [Powerex, Inc., Harrison, OH (United States); Prusia, Duane [Powerex, Inc., Harrison, OH (United States); Arnet, Beat [Azure Dynamics, Oak Park, MI (United States); Smith, Chris [Azure Dynamics, Oak Park, MI (United States); Cogan, Art [Azure Dynamics, Oak Park, MI (United States)

    2012-03-31

    The state-of-the-art hybrid electric vehicles (HEVs) require the inverter cooling system to have a separate loop to avoid power semiconductor junction over temperatures because the engine coolant temperature of 105°C does not allow for much temperature rise in silicon devices. The proposed work is to develop an advanced soft-switching inverter that will eliminate the device switching loss and cut down the power loss so that the inverter can operate at high-temperature conditions while operating at high switching frequencies with small current ripple in low inductance based permanent magnet motors. The proposed tasks also include high-temperature packaging and thermal modeling and simulation to ensure the packaged module can operate at the desired temperature. The developed module will be integrated with the motor and vehicle controller for dynamometer and in-vehicle testing to prove its superiority. This report will describe the detailed technical design of the soft-switching inverters and their test results. The experiments were conducted both in module level for the module conduction and switching characteristics and in inverter level for its efficiency under inductive and dynamometer load conditions. The performance will be compared with the DOE original specification.

  2. Measurement of anisotropic soft X-ray emission during radio-frequency current drive in the JFT-2M tokamak

    International Nuclear Information System (INIS)

    Kawashima, Hisato; Matoba, Tohru; Hoshino, Katsumichi; Kawakami, Tomohide; Yamamoto, Takumi; Hasegawa, Mitsuru; Fuchs, Gerhard; Uesugi, Yoshihiko.

    1994-01-01

    A new vertical soft X-ray pulse height analyzer (PHA) system and a tangential PHA system were used to measure the anisotropy of soft X-ray emission during lower-hybrid current drive (LHCD) and also during current drive by the combination of LHCD and electron cyclotron resonance heating (ECRH) in the JFT-2M tokamak. The strong soft X-ray emission was measured in the parallel forward direction during LHCD. When ECRH was applied during LHCD, the perpendicular emission was enhanced. The high-energy electron velocity distribution was evaluated by comparing the measured and calculated X-ray spectra. The distribution form was consistent with the theoretical prediction based on the electron Landau damping of lower-hybrid waves and the electron cyclotron damping of electron cyclotron waves for reasonable energy ranges. (author)

  3. Development of 4.6 GHz lower hybrid current drive system for steady state and high performance plasma in EAST

    Energy Technology Data Exchange (ETDEWEB)

    Liu, F.K.; Li, J.G.; Shan, J.F.; Wang, M.; Liu, L.; Zhao, L.M.; Hu, H.C.; Feng, J.Q.; Yang, Y.; Jia, H.; Wang, X.J.; Wu, Z.G.; Ma, W.D.; Huang, Y.Y.; Xu, H.D.; Zhang, J.; Cheng, M.; Xu, L.; Li, M.H.; Li, Y.C.; and others

    2016-12-15

    In order to achieve steady state and high performance plasma in EAST, a new lower hybrid current drive system at a frequency of 4.6 GHz has been built. The system is composed of 24 continuous wave (CW) klystron amplifiers to generate 6MW/CW microwave, 24 standard rectangle waveguide transmission lines with water-cooling plate, a multi-junction grill composed of 576 active (in groups of 8) and 84 passive sub-waveguides arranged in 12 rows and 6 columns, and four sets of high voltage power supplies. The power value and the spectrum of the launched microwave from the antenna can be controlled by the low-power microwave circuits in front of the klystrons. The new LHCD system has been applied to the experiments on EAST tokmak since 2014, and the obtained results suggest that it is effective to couple the wave into plasma and drive plasma current.

  4. ORIENTED FOR CAD UNIVERSAL MATHEMATICAL MODEL OF THE EDDY CURRENT PROBE. PART 1. THE RESULTING FIELD OF THE DRIVE WINDING

    Directory of Open Access Journals (Sweden)

    A. G. Dedegkaev

    2015-01-01

    Full Text Available The work relates to the field of CAD methods and means of nondestructive electromagnetic testing of conductive flat products. The problem of constructing mathematical model of the drive winding eddy current probe linearly extended form is polygon in cross section. This allows you to create a universal mathematical model, which includes a model of a simpler shape in cross-section, as a special case. 

  5. Current implementation of advance encryption standard (AES) S-Box

    African Journals Online (AJOL)

    Although the attack on cryptosystem is still not severe, the development of the scheme is still ongoing especially for the design of S-Box. Two main approach has beenused, which are heuristic method and algebraic method. Algebraic method as in current AES implementation has been proven to be the most secure S-Box ...

  6. Current advances in T-cell-based cancer immunotherapy

    Science.gov (United States)

    Wang, Mingjun; Yin, Bingnan; Wang, Helen Y; Wang, Rong-Fu

    2015-01-01

    Cancer is a leading cause of death worldwide; due to the lack of ideal cancer biomarkers for early detection or diagnosis, most patients present with late-stage disease at the time of diagnosis, thus limiting the potential for successful treatment. Traditional cancer treatments, including surgery, chemotherapy and radiation therapy, have demonstrated very limited efficacy for patients with late-stage disease. Therefore, innovative and effective cancer treatments are urgently needed for cancer patients with late-stage and refractory disease. Cancer immunotherapy, particularly adoptive cell transfer, has shown great promise in the treatment of patients with late-stage disease, including those who are refractory to standard therapies. In this review, we will highlight recent advances and discuss future directions in adoptive cell transfer based cancer immunotherapy. PMID:25524383

  7. Advances in NDT and Materials Characterization by Eddy Currents

    OpenAIRE

    Almeida, G.; Gonzalez, J.; Rosado, L.; Vilaça, P.; Santos, Telmo G.

    2013-01-01

    VK: T20309 New materials and production technologies demand improved non-destructive techniques for inspection and defect evaluation, especially when critical safety applications are involved. In this paper a new non-destructive testing (NDT) system is presented. The innovative system is composed by a new type of eddy currents probe, electronic devices for signal generation, conditioning and conversion, automated mechanized scanning and analysis software. This new probe provides enhanced l...

  8. EVALUATION OF RESULTS OF ROAD RESEARCH OF LANOS CAR, EQUIPPED WITH AN ADVANCED HYDRAULIC BRAKE DRIVE

    Directory of Open Access Journals (Sweden)

    I. Nazarov

    2016-12-01

    Full Text Available The results of studies of road emergency braking of the car, the brake system equipped with an improved hydraulic brake actuator according to the patent number 76189 Ukraine are analyzed. This drive provides more efficient emergency braking of cars under operating conditions by of installing in each of the contours of the rear brakes one brake-power, each of which provides distribution of braking forces between the wheels of the corresponding side.

  9. A study on optimization of hybrid drive train using Advanced Vehicle Simulator (ADVISOR)

    Science.gov (United States)

    Same, Adam; Stipe, Alex; Grossman, David; Park, Jae Wan

    This study investigates the advantages and disadvantages of three hybrid drive train configurations: series, parallel, and "through-the-ground" parallel. Power flow simulations are conducted with the MATLAB/Simulink-based software ADVISOR. These simulations are then applied in an application for the UC Davis SAE Formula Hybrid vehicle. ADVISOR performs simulation calculations for vehicle position using a combined backward/forward method. These simulations are used to study how efficiency and agility are affected by the motor, fuel converter, and hybrid configuration. Three different vehicle models are developed to optimize the drive train of a vehicle for three stages of the SAE Formula Hybrid competition: autocross, endurance, and acceleration. Input cycles are created based on rough estimates of track geometry. The output from these ADVISOR simulations is a series of plots of velocity profile and energy storage State of Charge that provide a good estimate of how the Formula Hybrid vehicle will perform on the given course. The most noticeable discrepancy between the input cycle and the actual velocity profile of the vehicle occurs during deceleration. A weighted ranking system is developed to organize the simulation results and to determine the best drive train configuration for the Formula Hybrid vehicle. Results show that the through-the-ground parallel configuration with front-mounted motors achieves an optimal balance of efficiency, simplicity, and cost. ADVISOR is proven to be a useful tool for vehicle power train design for the SAE Formula Hybrid competition. This vehicle model based on ADVISOR simulation is applicable to various studies concerning performance and efficiency of hybrid drive trains.

  10. Long pulse FRC sustainment with enhanced edge driven rotating magnetic field current drive

    International Nuclear Information System (INIS)

    Hoffman, A.L.; Guo, H.Y.; Miller, K.E.; Milroy, R.D.

    2005-01-01

    FRCs have been formed and sustained for up to 50 normal flux decay times by Rotating Magnetic Fields (RMF) in the TCS experiment. For these longer pulse times a new phenomenon has been observed: switching to a higher performance mode delineated by shallower RMF penetration, higher ratios of generated poloidal to RMF drive field, and lower overall plasma resistivity. This global data is not explainable by previous RMF theory based on uniform electron rotational velocities or by numerical calculations based on uniform plasma resistivity, but agrees in many respects with new calculations made using strongly varying resistivity profiles. In order to more realistically model RMF driven FRCs with such non-uniform resistivity profiles, a double rigid rotor model has been developed with separate inner and outer electron rotational velocities and resistivities. The results of this modeling suggest that the RMF drive results in very high resistivity in a narrow edge layer, and that the higher performance mode is characterized by a sharp reduction in resistivity over the bulk of the FRC. (author)

  11. Current breast imaging modalities, advances, and impact on breast care.

    Science.gov (United States)

    Garcia, Evelyn M; Storm, Erik S; Atkinson, Lisa; Kenny, Eileen; Mitchell, Lisa S

    2013-09-01

    Mammography will continue as the breast cancer screening imaging study of choice for the foreseeable future. Ultrasound and magnetic resonance imaging (MRI) are widely available adjunctive studies for women with suspicious mammographic or clinical findings, and MRI is a screening tool for women with specific increased risks for breast cancer. Options for diagnosis will continue to evolve and progress. This article discusses a wide variety of imaging options currently used and in development, their strengths, limitations, and potential future roles in the continuing pursuit of early breast cancer diagnosis, treatment, and follow-up. Copyright © 2013 Elsevier Inc. All rights reserved.

  12. Advanced ultrasonic and eddy current examinations of the reactor vessel

    International Nuclear Information System (INIS)

    Cvitanovic, M.; Zado, V.

    1996-01-01

    In order to improve safety and reliability of nuclear power plant components, the existing examination methods are permanently developed as well as the new methods of examination are implemented. For the same reason, beside referent requirements, complementary NDE methods are utilized. Some examination methods techniques are not required to be used by referent safety codes and standards but they are frequently practiced as additional prevention to the component failure. This article presents the state of the art methods and techniques currently applied for examination of the reactor vessel base material, clad and weld materials. (author)

  13. Pathophysiology of recent advances in current thyroid function testing

    International Nuclear Information System (INIS)

    Hesch, R.D.

    1977-01-01

    In the first chapter I have discussed thyroid function and thyroid status which is determined by thyroid gland function in secreting T4 and peripheral biotransformation of T4. The accuracy of a current in-vitro diagnostic strategy allows high reliability in clinical routine. More recent test procedures for iodothyronines and immunological phenomena need further evaluation. In another chapter the biotransformation of T4 to bioactive and regulatory iodothyronines with respect to possible clinical implications is discussed. Finally, the role of TBG for interpration of T4 and T3 concentrations is determined and more attention directed to its functional heterogeneity. (orig.) [de

  14. Current drive drift waves as a possible mechanism for dynamo effect and transport in reversed field pinches

    International Nuclear Information System (INIS)

    Briguglio, S.; Romanelli, F.; Vlad, G.

    1986-01-01

    The possibility that a current driven drift wave turbulence may be responsible for the outward ion flux observed in Reversed Field Pinches (RFPs) is investigated; the latter flux was recently proposed as the driving mechanism of the dynamo sustaining the poloidal current in the external region of an RFP discharge. It is shown that this possibility can be supported by the linear theory of current driven drift waves. Finally, on the assumption that the transport is dominated by these instabilities, a scaling law for the temperature in RFPs is derived, which shows an approximately linear dependence on the current and a weak dependence on the size of the machine, in agreement with the experimental results. (author)

  15. Current advancements and challenges in soil-root interactions modelling

    Science.gov (United States)

    Schnepf, Andrea; Huber, Katrin; Abesha, Betiglu; Meunier, Felicien; Leitner, Daniel; Roose, Tiina; Javaux, Mathieu; Vanderborght, Jan; Vereecken, Harry

    2015-04-01

    Roots change their surrounding soil chemically, physically and biologically. This includes changes in soil moisture and solute concentration, the exudation of organic substances into the rhizosphere, increased growth of soil microorganisms, or changes in soil structure. The fate of water and solutes in the root zone is highly determined by these root-soil interactions. Mathematical models of soil-root systems in combination with non-invasive techniques able to characterize root systems are a promising tool to understand and predict the behaviour of water and solutes in the root zone. With respect to different fields of applications, predictive mathematical models can contribute to the solution of optimal control problems in plant recourse efficiency. This may result in significant gains in productivity, efficiency and environmental sustainability in various land use activities. Major challenges include the coupling of model parameters of the relevant processes with the surrounding environment such as temperature, nutrient concentration or soil water content. A further challenge is the mathematical description of the different spatial and temporal scales involved. This includes in particular the branched structures formed by root systems or the external mycelium of mycorrhizal fungi. Here, reducing complexity as well as bridging between spatial scales is required. Furthermore, the combination of experimental and mathematical techniques may advance the field enormously. Here, the use of root system, soil and rhizosphere models is presented through a number of modelling case studies, including image based modelling of phosphate uptake by a root with hairs, model-based optimization of root architecture for phosphate uptake from soil, upscaling of rhizosphere models, modelling root growth in structured soil, and the effect of root hydraulic architecture on plant water uptake efficiency and drought resistance.

  16. Assessing Risk and Driving Risk Mitigation for First-of-a-Kind Advanced Reactors

    Energy Technology Data Exchange (ETDEWEB)

    John W. Collins

    2011-09-01

    Planning and decision making amidst programmatic and technological risks represent significant challenges for projects. This presentation addresses the four step risk-assessment process needed to determine clear path forward to mature needed technology and design, license, and construct advanced nuclear power plants, which have never been built before, including Small Modular Reactors. This four step process has been carefully applied to the Next Generation Nuclear Plant. STEP 1 - Risk Identification Risks are identified, collected, and categorized as technical risks, programmatic risks, and project risks, each of which result in cost and schedule impacts if realized. These include risks arising from the use of technologies not previously demonstrated in a relevant application. These risks include normal and accident scenarios which the SMR could experience including events that cause the disablement of engineered safety features (typically documented in Phenomena Identification Ranking Tables (PIRT) as produced with the Nuclear Regulatory Commission) and design needs which must be addressed to further detail the design. Product - Project Risk Register contained in a database with sorting, presentation, rollup, risk work off functionality similar to the NGNP Risk Management System . STEP 2 - Risk Quantification The risks contained in the risk register are then scored for probability of occurrence and severity of consequence, if realized. Here the scoring methodology is established and the basis for the scoring is well documented. Product - Quantified project risk register with documented basis for scoring. STEP 3 - Risk Handling Strategy Risks are mitigated by applying a systematic approach to maturing the technology through Research and Development, modeling, test, and design. A Technology Readiness Assessment is performed to determine baseline Technology Readiness Levels (TRL). Tasks needed to mature the technology are developed and documented in a roadmap

  17. Assessing Risk and Driving Risk Mitigation for First-of-a-Kind Advanced Reactors

    International Nuclear Information System (INIS)

    Collins, John W.

    2011-01-01

    Planning and decision making amidst programmatic and technological risks represent significant challenges for projects. This presentation addresses the four step risk-assessment process needed to determine clear path forward to mature needed technology and design, license, and construct advanced nuclear power plants, which have never been built before, including Small Modular Reactors. This four step process has been carefully applied to the Next Generation Nuclear Plant. STEP 1 - Risk Identification Risks are identified, collected, and categorized as technical risks, programmatic risks, and project risks, each of which result in cost and schedule impacts if realized. These include risks arising from the use of technologies not previously demonstrated in a relevant application. These risks include normal and accident scenarios which the SMR could experience including events that cause the disablement of engineered safety features (typically documented in Phenomena Identification Ranking Tables (PIRT) as produced with the Nuclear Regulatory Commission) and design needs which must be addressed to further detail the design. Product - Project Risk Register contained in a database with sorting, presentation, rollup, risk work off functionality similar to the NGNP Risk Management System . STEP 2 - Risk Quantification The risks contained in the risk register are then scored for probability of occurrence and severity of consequence, if realized. Here the scoring methodology is established and the basis for the scoring is well documented. Product - Quantified project risk register with documented basis for scoring. STEP 3 - Risk Handling Strategy Risks are mitigated by applying a systematic approach to maturing the technology through Research and Development, modeling, test, and design. A Technology Readiness Assessment is performed to determine baseline Technology Readiness Levels (TRL). Tasks needed to mature the technology are developed and documented in a roadmap

  18. Radial profiles of hard X-ray emission during steady state current drive in the TRIAM-1M tokamak

    International Nuclear Information System (INIS)

    Nakamura, Y.; Takabatake, Y.; Jotaki, E.; Moriyama, S.; Nagao, A.; Nakamura, K.; Hiraki, N.; Itoh, S.

    1990-01-01

    The hard X-ray emission from the TRIAM-1M tokamak plasma during steady state lower hybrid current drive with a discharge duration of a few minutes was measured with sodium iodide scintillation spectrometers. The radial profiles of the X-ray emission were also measured and indicate that, in the low density regime (n e =(1-3)x10 12 cm -3 ), the current carrying high energy electrons are mainly in the inner region of the plasma column and their radial profile remains unchanged during current drive. On the other hand, high density discharges (n e =(3-6)x10 12 cm -3 ) are always accompanied by an abrupt drop of the plasma current, and the X-ray emission profile changes from peaked to broad. This change can be attributed to the conditions of wave accessibility. As the electron density increases, the accessibility of the plasma to lower hybrid waves with low values of the parallel wave number n parallel is significantly reduced and high energy electrons resonating with the waves are produced at the plasma periphery. Interaction of these electrons with the limiters causes an increase of the electron density in this region; waves with low n parallel then become completely excluded from the inner part of the plasma column. This interpretation is supported by measurements of the density profile and impurity radiation, and has been confirmed in an investigation of discharges with additional gas puffing. (author). 17 refs, 21 figs

  19. Current advances in transdermal delivery of drugs for Alzheimer's disease.

    Science.gov (United States)

    Nguyen, Thuy Trang; Giau, Vo Van; Vo, Tuong Kha

    2017-01-01

    Alzheimer's disease (AD) is a common, progressive, fatal neurodegenerative disorder, which will play an increasingly important role both socially and financially in the aging populations. Treatments for AD show modest improvements in cognition and global functioning among patients. Furthermore, the oral administration of treating AD has had some drawbacks that decrease the medication adherence and efficacy of the therapy. Transdermal drugs are proposed as an alternative remedy to overcome the disadvantages of current pharmaceutical dosage options for this chronic disorder. They could have different strengths, such as offering a stable diffusion of active substance, avoiding the first pass metabolism, and reducing system adverse reactions. This article reviews the technical principles, novel techniques of transdermal delivery drug, and prospects for future development for the management of cognitive and behavioral dysfunctions in AD patients.

  20. The current state of industry development in Ukraine: advance perspective

    Directory of Open Access Journals (Sweden)

    Skyba Maryna Valeriyivna

    2015-02-01

    Full Text Available The current state of the industry of Ukraine are considered at the article. The author determined that the stabilization of the situation and further development of the industry need first of all cessation of hostilities. It is necessary to implement effective measures to combat corruption, the development of consistent, constructive and concerted action on the formation of institutions guaranteeing stability, predictability and transparency of the market rules and procedures that minimize the impact of shadow factors, and implementation of professional privatization and limitation of monopoly at the markets, forming a transparent, competitive business environment, the introduction of new energy saving technologies. These measures will help attract investment, increase production and improve enterprise profitability.

  1. Advanced power flow technologies for high current ICF accelerators

    International Nuclear Information System (INIS)

    VanDevender, J.P.; McDaniel, D.H.

    1978-01-01

    Two new technologies for raising the power density in high current, inertial confinement fusion accelerators have been developed in the past two years. Magnetic flashover inhibition utilizes the self-magnetic fields around the vacuum insulator surface to inhibit surface flashover; average electric fields of 40 Mv/m at magnetic fields of 1.1 T have been achieved. Self-magnetic insulation of long, vacuum transmission lines has been used to transport power at 1.6 x 10 14 W/m 2 over six meters and up to 1.6 x 10 15 W/m 2 over short distances in a radial anode-cathode feed. The recent data relevant to these new technologies and their implications for ICF will be explored

  2. A mechanism for driving the gross Birkeland current configuration in the auroral oval

    International Nuclear Information System (INIS)

    Rostoker, G.; Bostrom, R.

    1976-01-01

    Birkeland (field-aligned) sheet currents flowing into and out of the auroral oval as reported by Zmuda and Armstrong (1974) are integrally associated with convective motion of plasma in the magnetotail. It is demonstrated that these currents can be driven by energy supplied by the braking of this convective motion of the plasma sheet particles as they drift toward the flanks of the magnetosphere. In the ionosphere the sheet currents close as Pedersen currents, resulting in the dissipation of power, while far from the earth the closure currents, which provide the braking force for the plasma, flow in the plasma sheet approximately normal to the neutral sheet out to radial distances of about 80 R/subE/. During periods of moderate magnetospheric activity the Birkeland currents result in a rate of dissipation of convective energy of the order of 10 GW

  3. Study on Rotor Current Waveforms in an Inverter-fed Induction Motor Drive During Overmodulation

    OpenAIRE

    Hari, Pavan Kumar VSS; Narayanan, G

    2011-01-01

    Overmodulation introduces low-order harmonics in the output voltage of a voltage source inverter. This paper presents the effects of low-order harmonics in the stator voltage on the rotor currents of an induction motor. Rotor current waveforms are presented for various operating zones in overmodulation, including six-step mode. Harmonic spectra of stator and rotor currents are compared in six-step mode of operation. Pulsating torque is evaluated at various depths of modulation during ov...

  4. Advanced therapy medicinal products: current and future perspectives.

    Science.gov (United States)

    Hanna, Eve; Rémuzat, Cécile; Auquier, Pascal; Toumi, Mondher

    2016-01-01

    Advanced therapy medicinal products (ATMPs) are innovative therapies that encompass gene therapy, somatic cell therapy, and tissue-engineered products. These therapies are expected to bring important health benefits, but also to substantially impact the pharmaceuticals budget. The aim of this study was to characterise the ATMPs in development and discuss future implications in terms of market access. Clinical trials were searched in the following databases: EudraCT (EU Drug Regulating Authorities Clinical Trials), ClinicalTrials.gov, and ICTRP (International Clinical Trials Registry Platform of the World Health Organization). Trials were classified by category of ATMP as defined by European regulation EC No. 1394/2007, as well as by development phase and disease area. The database search identified 939 clinical trials investigating ATMPs (85% ongoing, 15% completed). The majority of trials were in the early stages (Phase I, I/II: 64.3%, Phase II, II/III: 27.9%, Phase 3: 6.9%). Per category of ATMP, we identified 53.6% of trials for somatic cell therapies, 22.8% for tissue-engineered products, 22.4% for gene therapies, and 1.2% for combined products (incorporating a medical device). Disease areas included cancer (24.8%), cardiovascular diseases (19.4%), musculoskeletal (10.5%), immune system and inflammation (11.5%), neurology (9.1%), and others. Of the trials, 47.2% enrolled fewer than 25 patients. Due to the complexity and specificity of ATMPs, new clinical trial methodologies are being considered (e.g., small sample size, non-randomised trials, single-arm trials, surrogate endpoints, integrated protocols, and adaptive designs). Evidence generation post-launch will become unavoidable to address payers' expectations. ATMPs represent a fast-growing field of interest. Although most of the products are in an early development phase, the combined trial phase and the potential to cure severe chronic conditions suggest that ATMPs may reach the market earlier than

  5. Preemptive analgesia II: recent advances and current trends.

    LENUS (Irish Health Repository)

    Kelly, D J

    2012-02-03

    PURPOSE: This two-part review summarizes the current knowledge of physiological mechanisms, pharmacological modalities and controversial issues surrounding preemptive analgesia. SOURCE: Articles from 1966 to present were obtained from the MEDLINE databases. Search terms included analgesia, preemptive; neurotransmitters; pain, postoperative; hyperalgesia; sensitization, central nervous system; pathways, nociception; anesthetic techniques; analgesics, agents. Principal findings: In Part I of this review article, techniques and agents that attenuate or prevent central and peripheral sensitization were reviewed. In Part II, the conditions required for effective preemptive techniques are evaluated. Specifically, preemptive analgesia may be defined as an antinociceptive treatment that prevents establishment of altered central processing of afferent input from sites of injury. The most important conditions for establishment of effective preemptive analgesia are the establishment of an effective level of antinociception before injury, and the continuation of this effective analgesic level well into the post-injury period to prevent central sensitization during the inflammatory phase. Although single-agent therapy may attenuate the central nociceptive processing, multi-modal therapy is more effective, and may be associated with fewer side effects compared with the high-dose, single-agent therapy. CONCLUSION: The variable patient characteristics and timing of preemptive analgesia in relation to surgical noxious input require individualization of the technique(s) chosen. Multi-modal analgesic techniques appear more effective.

  6. Cutaneous wound healing: Current concepts and advances in wound care

    Directory of Open Access Journals (Sweden)

    Kenneth C Klein

    2014-01-01

    Full Text Available A non-healing wound is defined as showing no measurable signs of healing for at least 30 consecutive treatments with standard wound care. [1] It is a snapshot of a patient′s total health as well as the ongoing battle between noxious factors and the restoration of optimal macro and micro circulation, oxygenation and nutrition. In practice, standard therapies for non-healing cutaneous wounds include application of appropriate dressings, periodic debridement and eliminating causative factors. [2] The vast majority of wounds would heal by such approach with variable degrees of residual morbidity, disability and even mortality. Globally, beyond the above therapies, newer tools of healing are selectively accessible to caregivers, for various logistical or financial reasons. Our review will focus on the use of hyperbaric oxygen therapy (HBOT, as used at our institution (CAMC, and some other modalities that are relatively accessible to patients. HBOT is a relatively safe and technologically simpler way to deliver care worldwide. However, the expense for including HBOT as standard of care for recognized indications per UHMS(Undersea and Hyperbaric Medical Society may vary widely from country to country and payment system. [3] In the USA, CMS (Centers for Medicare and Medicaid Services approved indications for HBOT vary from that of the UHMS for logistical reasons. [1] We shall also briefly look into other newer therapies per current clinical usage and general acceptance by the medical community. Admittedly, there would be other novel tools with variable success in wound healing worldwide, but it would be difficult to include all in this treatise.

  7. Current advances on ABC drug transporters in fish.

    Science.gov (United States)

    Luckenbach, Till; Fischer, Stephan; Sturm, Armin

    2014-09-01

    Most members of the large ATP-binding cassette (ABC) gene family are transporters involved in substrate translocation across biological membranes. In eukaryotes, ABC proteins functioning as drug transporters are located in the plasma membrane and mediate the cellular efflux of a wide range of organic chemicals, with some transporters also transporting certain metals. As the enhanced expression of ABC drug transporters can confer multidrug resistance (MDR) to cancers and multixenobiotic resistance (MXR) to organisms from polluted habitats, these ABC family members are also referred to as MDR or MXR proteins. In mammals, ABC drug transporters show predominant expression in tissues involved in excretion or constituting internal or external body boundaries, where they facilitate the excretion of chemicals and their metabolites, and limit chemical uptake and penetration into "sanctuary" sites of the body. Available knowledge about ABC proteins is still limited in teleost fish, a large vertebrate group of high ecological and economic importance. Using transport activity measurements and immunochemical approaches, early studies demonstrated similarities in the tissue distribution of ABC drug transporters between teleosts and mammals, suggesting conserved roles of the transporters in the biochemical defence against toxicants. Recently, the availability of teleost genome assemblies has stimulated studies of the ABC family in this taxon. This review summarises the current knowledge regarding the genetics, functional properties, physiological function, and ecotoxicological relevance of teleostean ABC transporters. The available literature is reviewed with emphasis on recent studies addressing the tissue distribution, substrate spectrum, regulation, physiological function and phylogenetic origin of teleostean ABC transporters. Copyright © 2014 The Authors. Published by Elsevier Inc. All rights reserved.

  8. Cutaneous wound healing: Current concepts and advances in wound care

    Science.gov (United States)

    Klein, Kenneth C; Guha, Somes Chandra

    2014-01-01

    A non-healing wound is defined as showing no measurable signs of healing for at least 30 consecutive treatments with standard wound care.[1] It is a snapshot of a patient's total health as well as the ongoing battle between noxious factors and the restoration of optimal macro and micro circulation, oxygenation and nutrition. In practice, standard therapies for non-healing cutaneous wounds include application of appropriate dressings, periodic debridement and eliminating causative factors.[2] The vast majority of wounds would heal by such approach with variable degrees of residual morbidity, disability and even mortality. Globally, beyond the above therapies, newer tools of healing are selectively accessible to caregivers, for various logistical or financial reasons. Our review will focus on the use of hyperbaric oxygen therapy (HBOT), as used at our institution (CAMC), and some other modalities that are relatively accessible to patients. HBOT is a relatively safe and technologically simpler way to deliver care worldwide. However, the expense for including HBOT as standard of care for recognized indications per UHMS(Undersea and Hyperbaric Medical Society) may vary widely from country to country and payment system.[3] In the USA, CMS (Centers for Medicare and Medicaid Services) approved indications for HBOT vary from that of the UHMS for logistical reasons.[1] We shall also briefly look into other newer therapies per current clinical usage and general acceptance by the medical community. Admittedly, there would be other novel tools with variable success in wound healing worldwide, but it would be difficult to include all in this treatise. PMID:25593414

  9. Page 1 Switched reluctance motor drives – recent advances 831 5.1 ...

    Indian Academy of Sciences (India)

    A bi-cubic spline interpolation was used to model the nonlinear experimental data. | This method optimizes the current overlap at all torque levels so as to minimize the peak r phase current. This current profiling algorithm results in the highest possible operating speed range under constant torque operation. The torque ...

  10. Lower hybrid current drive and heating experiments at the 1 MW rf power level on Alcator C

    International Nuclear Information System (INIS)

    Porkolab, M.; Lloyd, B.; Schuss, J.J.

    1983-07-01

    Lower hybrid current drive experiments were carried out in the density range 1.0 x 10 13 less than or equal to anti n(cm -3 ) less than or equal to 1.0 x 10 14 , at magnetic fields 6.0 less than or equal to B(T) less than or equal to 10. Using one 16 waveguide array, plasma currents of 150 to 200 kA have been driven by rf powers up to 600 kW for times greater than 100 msec at anti n/sub e/ up to 5 x 10 13 cm -3 . With two arrays at anti n/sub e/ approx. = 4.3 x 10 13 cm -3 at B/sub T/ = 10 T, plasma currents of 160 kA have been maintained by the rf power for 300 msec with zero loop voltage and constant internal inductance

  11. Non inductive formation of an extremely overdense spherical Tokamak by electron Bernstein wave heating and current drive on LATE

    Directory of Open Access Journals (Sweden)

    Uchida Masaki

    2015-01-01

    Full Text Available An extremely overdense special Tokamak plasma has been non-inductively formed and maintained by electron Bernstein (EB wave heating and current drive in the Low Aspect ratio Torus Experiment (LATE device. The plasma current reaches 12 kA and the line-averaged electron density exceeds 7 times the plasma cut off density by injecting a 2.45 GHz microwave power of 60 kW. Such a highly overdense plasma is obtained when the upper hybrid resonance layer lies to the higher field side of the 2nd harmonic ECR layer, which may realize a good coupling to EB waves at their first propagation band. The effect of the injection polarization on the mode conversion rate to EB waves at the extremely overdense regime has been investigated and an improvement in the plasma current is observed.

  12. From advanced driver assistance to autonomous driving: perspectives for photonics sensors

    Science.gov (United States)

    Cochard, Jacques; Bouyé, Clémentine

    2016-03-01

    Optics components entered in the automotive vehicle one century ago with headlamps and since then move towards even more sophisticated designs in lighting functions. Photonics sensors are just entering now in this market through driver assistance, in complement of incumbent ultrasonic and radar technologies. Gain of market shares is expected for this components with autonomous driving, that was few years ago a nice dream and whose early results exceed surprisingly expectations of roadmaps and historic OEM have quickly joined the course launched by Google Company 5 years ago. Technological components, among them CMOS camera followed by Laser Scanners, cost-effective flash LIDAR are already experimenting their first miles in real condition and new consumers in South Asia plebiscite this new way to drive cars .The issue is still for photonics companies to move from well suited technological solution to mass-production components with corresponding cost reduction. MEMS components that follow the same curve 15 years ago (with market entries in airbags, tire pressure monitoring systems…) experimented the hard pressure on price for wide market adoption. Besides price, which is a CFO issue, photonic technologies will keep in place if they can both reassure OEM CEO and let CTO and designers dream. Reassurance will be through higher level of standardization and reliability of these components whereas dream will be linked to innovative sensing application, e.g spectroscopy.

  13. Assessment of quasi-linear effect of RF power spectrum for enabling lower hybrid current drive in reactor plasmas

    Science.gov (United States)

    Cesario, Roberto; Cardinali, Alessandro; Castaldo, Carmine; Amicucci, Luca; Ceccuzzi, Silvio; Galli, Alessandro; Napoli, Francesco; Panaccione, Luigi; Santini, Franco; Schettini, Giuseppe; Tuccillo, Angelo Antonio

    2017-10-01

    The main research on the energy from thermonuclear fusion uses deuterium plasmas magnetically trapped in toroidal devices. To suppress the turbulent eddies that impair thermal insulation and pressure tight of the plasma, current drive (CD) is necessary, but tools envisaged so far are unable accomplishing this task while efficiently and flexibly matching the natural current profiles self-generated at large radii of the plasma column [1-5]. The lower hybrid current drive (LHCD) [6] can satisfy this important need of a reactor [1], but the LHCD system has been unexpectedly mothballed on JET. The problematic extrapolation of the LHCD tool at reactor graded high values of, respectively, density and temperatures of plasma has been now solved. The high density problem is solved by the FTU (Frascati Tokamak Upgrade) method [7], and solution of the high temperature one is presented here. Model results based on quasi-linear (QL) theory evidence the capability, w.r.t linear theory, of suitable operating parameters of reducing the wave damping in hot reactor plasmas. Namely, using higher RF power densities [8], or a narrower antenna power spectrum in refractive index [9,10], the obstacle for LHCD represented by too high temperature of reactor plasmas should be overcome. The former method cannot be used for routinely, safe antenna operations, Thus, only the latter key is really exploitable in a reactor. The proposed solutions are ultimately necessary for viability of an economic reactor.

  14. Effect of resonant-to-bulk electron momentum transfer on the efficiency of electron-cyclotron current drive

    International Nuclear Information System (INIS)

    Matsuda, Y.; Smith, G.R.; Cohen, R.H.

    1988-01-01

    Efficiency of current drive by electron-cyclotron waves is investigated numerically by a bounce-average Fokker-Planck code to elucidate the effects of momentum transfer from resonant to bulk electrons, finite bulk temperature relative to the energy of resonant electrons, and trapped electrons. Comparisons are made with existing theories to assess their validity and quantitative difference between theory and code results. Difference of nearly a factor of 2 was found in efficiency between some theory and code results. 4 refs., 4 figs

  15. A model for the advantage of early electron cyclotron current drive in the suppression of neoclassical tearing modes

    International Nuclear Information System (INIS)

    Lazaros, Avrilios; Maraschek, Marc; Zohm, Hartmut

    2007-01-01

    An analytic model for the advantage of the early application of electron cyclotron current drive (ECCD) in the suppression of neoclassical tearing modes (NTMs) is presented. The improved performance of early ECCD is attributed to the second (smaller) saturation island width, which appears for sufficiently small (relative to the ECCD deposition width) critical island widths, in the strongly nonlinear growth rate profile. The operational range for the advantage of early ECCD is obtained, and it is shown that it is favored by broad deposition profiles. The preliminary experimental results in ASDEX Upgrade [H. Zohm et al., Nucl. Fusion 41, 197 (2001)] are consistent with the present model

  16. Behavior of impurity ion velocities during the pulsed poloidal current drive in the Madison symmetric torus reversed-field pinch

    International Nuclear Information System (INIS)

    Sakakita, Hajime; Craig, Darren; Anderson, Jay K.; Chapman, Brett E.; Den-Hartog, Daniel J.; Prager, Stewart C.; Biewer, Ted M.; Terry, Stephen D.

    2003-01-01

    We report on passive measurements of impurity ion velocities during the pulsed poloidal current drive (PPCD) in the Madison Symmetric Torus reversed-field pinch. During PPCD, the electron temperature increased and a sudden reduction of magnetic fluctuations was observed. For this change, we have studied whether plasma velocity is affected. Plasma rotation is observed to decrease during PPCD. From measurements of line intensities for several impurities at 10 poloidal chords, it is found that the impurity line emission shifts outward. The ion temperature of impurities is reasonably connected to that measured by charge exchange recombination spectroscopy from core to edge. (author)

  17. A Review of Voltage and Current Signature Diagnosis in Industrial Drives

    OpenAIRE

    K. Vinoth Kumar

    2011-01-01

    This paper presents the review of identify the different types of faults in the induction motor during online condition by using current and voltage signature analysis. Special attention is focused on the effect of both space distribution of rotor breakage and rotor dis-symmetry on the mechanism of generation of diagnosis signatures with the consideration of voltage supply unbalance and speed ripples. A comparison is made between the voltage signature analysis and current signature analysis. ...

  18. The rationale driving the evolution of deep brain stimulation to constant-current devices.

    Science.gov (United States)

    Bronstein, Jeff M; Tagliati, Michele; McIntyre, Cameron; Chen, Robert; Cheung, Tyler; Hargreaves, Eric L; Israel, Zvi; Moffitt, Michael; Montgomery, Erwin B; Stypulkowski, Paul; Shils, Jay; Denison, Timothy; Vitek, Jerrold; Volkman, Jens; Wertheimer, Jeffrey; Okun, Michael S

    2015-02-01

    Deep brain stimulation (DBS) is an effective therapy for the treatment of a number of movement and neuropsychiatric disorders. The effectiveness of DBS is dependent on the density and location of stimulation in a given brain area. Adjustments are made to optimize clinical benefits and minimize side effects. Until recently, clinicians would adjust DBS settings using a voltage mode, where the delivered voltage remained constant. More recently, a constant-current mode has become available where the programmer sets the current and the stimulator automatically adjusts the voltage as impedance changes. We held an expert consensus meeting to evaluate the current state of the literature and field on constant-current mode versus voltage mode in clinical brain-related applications. There has been little reporting of the use of constant-current DBS devices in movement and neuropsychiatric disorders. However, as impedance varies considerably between patients and over time, it makes sense that all new devices will likely use constant current. © 2014 International Neuromodulation Society.

  19. Dynamics of Dirac strings and monopolelike excitations in chiral magnets under a current drive

    Science.gov (United States)

    Lin, Shi-Zeng; Saxena, Avadh

    2016-02-01

    Skyrmion lines in metallic chiral magnets carry an emergent magnetic field experienced by the conduction electrons. The inflow and outflow of this field across a closed surface is not necessarily equal, thus it allows for the existence of emergent monopoles. One example is a segment of skyrmion line inside a crystal, where a monopole and antimonopole pair is connected by the emergent magnetic flux line. This is a realization of Dirac stringlike excitations. Here we study the dynamics of monopoles in chiral magnets under an electric current. We show that in the process of creation of skyrmion lines, skyrmion line segments are first created via the proliferation of monopoles and antimonopoles. Then these line segments join and span the whole system through the annihilation of monopoles. The skyrmion lines are destroyed via the proliferation of monopoles and antimonopoles at high currents, resulting in a chiral liquid phase. We also propose to create the monopoles in a controlled way by applying an inhomogeneous current to a crystal. Remarkably, an electric field component in the magnetic field direction proportional to the current squared in the low current region is induced by the motion of distorted skyrmion lines, in addition to the Hall and longitudinal voltage. The existence of monopoles can be inferred from transport or imaging measurements.

  20. DESIGN, FABRICATION, AND TESTING OF AN ADVANCED, NON-POLLUTING TURBINE DRIVE GAS GENERATOR

    International Nuclear Information System (INIS)

    Unknown

    2002-01-01

    The objectives of this report period were to complete the development of the Gas Generator design, which was done; fabricate and test of the non-polluting unique power turbine drive gas Gas Generator, which has been postponed. Focus during this report period has been to complete the brazing and bonding necessary to fabricate the Gas Generator hardware, continue making preparations for fabricating and testing the Gas Generator, and continuing the fabrication of the Gas Generator hardware and ancillary hardware in preparation for the test program. Fabrication is more than 95% complete and is expected to conclude in early May 2002. the test schedule was affected by relocation of the testing to another test supplier. The target test date for hot fire testing is now not earlier than June 15, 2002

  1. High-Speed Current dq PI Controller for Vector Controlled PMSM Drive

    Science.gov (United States)

    Reaz, Mamun Bin Ibne; Rahman, Labonnah Farzana; Chang, Tae Gyu

    2014-01-01

    High-speed current controller for vector controlled permanent magnet synchronous motor (PMSM) is presented. The controller is developed based on modular design for faster calculation and uses fixed-point proportional-integral (PI) method for improved accuracy. Current dq controller is usually implemented in digital signal processor (DSP) based computer. However, DSP based solutions are reaching their physical limits, which are few microseconds. Besides, digital solutions suffer from high implementation cost. In this research, the overall controller is realizing in field programmable gate array (FPGA). FPGA implementation of the overall controlling algorithm will certainly trim down the execution time significantly to guarantee the steadiness of the motor. Agilent 16821A Logic Analyzer is employed to validate the result of the implemented design in FPGA. Experimental results indicate that the proposed current dq PI controller needs only 50 ns of execution time in 40 MHz clock, which is the lowest computational cycle for the era. PMID:24574913

  2. 75 FR 51437 - Notice of Request for Extension of a Currently Approved Information Collection (Advanced Meat...

    Science.gov (United States)

    2010-08-20

    ... Request for Extension of a Currently Approved Information Collection (Advanced Meat Recovery) AGENCY: Food... information collection regarding the regulatory requirements associated with the production of meat from Advanced Meat Recovery systems because the OMB approval will expire on January 31, 2011. DATES: Comments on...

  3. Effects of modulation techniques on the input current interharmonics of Adjustable Speed Drives

    DEFF Research Database (Denmark)

    Soltani, Hamid; Davari, Pooya; Zare, Firuz

    2018-01-01

    operation of the grid. This paper presents the effect of the symmetrical regularly sampled Space Vector Modulation (SVM) and Discontinuous Pulse Width Modulation-30olag (DPWM2) techniques, as the most popular modulation methods in the ASD applications, on the drive’s input current interharmonic magnitudes....... Further investigations are also devoted to the cases, where the Random Modulation (RM) technique is applied on the selected modulation strategies. The comparative results show that how different modulation techniques can influence the ASD’s input current interharmonics and consequently may...

  4. Two-dimensional effects in the problem of tearing modes control by electron cyclotron current drive

    International Nuclear Information System (INIS)

    Comisso, L.; Lazzaro, E.

    2010-01-01

    The design of means to counteract robustly the classical and neoclassical tearing modes in a tokamak by localized injection of an external control current requires an ever growing understanding of the physical process, beyond the Rutherford-type zero-dimensional models. Here a set of extended magnetohydrodynamic nonlinear equations for four continuum fields is used to investigate the two-dimensional effects in the response of the reconnecting modes to specific inputs of the localized external current. New information is gained on the space- and time-dependent effects of the external action on the two-dimensional structure of magnetic islands, which is very important to formulate applicable control strategies.

  5. On the merits of heating and current drive for tearing mode stabilization

    NARCIS (Netherlands)

    De Lazzari, D.; Westerhof, E.

    2009-01-01

    Neoclassical tearing modes (NTMs) are magnetohydrodynamic modes that can limit the performance of high beta discharges in a tokamak, leading eventually to a plasma disruption. A NTM is sustained by the perturbation of the 'bootstrap' current, which is a consequence of the pressure

  6. Parametric study of lower-hybrid current drive in the FED-A design

    International Nuclear Information System (INIS)

    Iida, H.; Ehst, D.A.; Peng, Y.K.M.

    1983-08-01

    In the FED-A concept, a quasi-steady-state operating scenario is conceived in which the plasma current is maintained by the transformer coil during burn at high density and by the lower hybrid wave during transformer recharge at low density. A parametric study is carried out to obtain optimum plasma and wave parameters in the recharging phase

  7. Performance Evaluation of Electronic Inductor-Based Adjustable Speed Drives with Respect to Line Current Interharmonics

    DEFF Research Database (Denmark)

    Soltani, Hamid; Davari, Pooya; Blaabjerg, Frede

    2017-01-01

    attractive due to its improved harmonic performance compared to a conventional ASD. In this digest, the input currents of the EI-based ASD are investigated and compared with the conventional ASDs with respect to interharmonics, which is an emerging power quality topic. First, the main causes...

  8. Comparison of Output Current Ripple in Single and Dual Three-Phase Inverters for Electric Vehicle Motor Drives

    Directory of Open Access Journals (Sweden)

    Jelena Loncarski

    2015-04-01

    Full Text Available The standard solution for the traction system in battery powered electric vehicles (EVs is a two-level (2L inverter feeding a three-phase motor. A simple and effective way to achieve a three-level (3L inverter in battery-supplied electric vehicles consists of using two standard three-phase 2L inverters with the open-end winding connection of standard three-phase ac motors. The 3L inverter solution can be usefully adopted in EVs since it combines several benefits such as current ripple reduction, increment of phase motor voltage with limited voltage ratings of the two battery banks, improvement in system reliability, etc. The reduction in current ripple amplitude is particularly relevant since it is a source of electromagnetic interference and audio noise from the inverter-motor power connection cables and from the motor itself. By increasing the inverter switching frequency the ripple amplitude is reduced, but the drive efficiency decreases due to the proportionally increased switching losses. In this paper the peak-to-peak ripple amplitude of the dual-2L inverter is evaluated and compared with the corresponding ripple of the single-2L inverter, considering the same voltage and power motor ratings. The ripple analysis is carried out as a function of the modulation index to cover the whole modulation range of the inverter, and the theoretical results are verified with experimental tests carried out by an inverter-motor drive prototype.

  9. Non-linear effects in electron cyclotron current drive applied for the stabilization of neoclassical tearing modes

    International Nuclear Information System (INIS)

    Ayten, B.; Westerhof, E.

    2014-01-01

    Due to the smallness of the volumes associated with the flux surfaces around the O-point of a magnetic island, the electron cyclotron power density applied inside the island for the stabilization of neoclassical tearing modes (NTMs) can exceed the threshold for non-linear effects as derived previously by Harvey et al (1989 Phys. Rev. Lett. 62 426). We study the non-linear electron cyclotron current drive (ECCD) efficiency through bounce-averaged, quasi-linear Fokker–Planck calculations in the magnetic geometry as created by the islands. The calculations are performed for the parameters of a typical NTM stabilization experiment on ASDEX Upgrade. A particular feature of these experiments is that the rays of the EC wave beam propagate tangential to the flux surfaces in the power deposition region. The calculations show significant non-linear effects on the ECCD efficiency, when the ECCD power is increased from its experimental value of 1 MW to a larger value of 4 MW. The nonlinear effects are largest in the case of locked islands or when the magnetic island rotation period is longer than the collisional time scale. The non-linear effects result in an overall reduction of the current drive efficiency for this case with absorption of the EC power on the low-field side of the electron cyclotron resonance layer. As a consequence of the non-linear effects, also the stabilizing effect of the ECCD on the island is reduced from linear expectations. (paper)

  10. Current harmonics elimination control method for six-phase PM synchronous motor drives.

    Science.gov (United States)

    Yuan, Lei; Chen, Ming-liang; Shen, Jian-qing; Xiao, Fei

    2015-11-01

    To reduce the undesired 5th and 7th stator harmonic current in the six-phase permanent magnet synchronous motor (PMSM), an improved vector control algorithm was proposed based on vector space decomposition (VSD) transformation method, which can control the fundamental and harmonic subspace separately. To improve the traditional VSD technology, a novel synchronous rotating coordinate transformation matrix was presented in this paper, and only using the traditional PI controller in d-q subspace can meet the non-static difference adjustment, the controller parameter design method is given by employing internal model principle. Moreover, the current PI controller parallel with resonant controller is employed in x-y subspace to realize the specific 5th and 7th harmonic component compensation. In addition, a new six-phase SVPWM algorithm based on VSD transformation theory is also proposed. Simulation and experimental results verify the effectiveness of current decoupling vector controller. Copyright © 2015 ISA. Published by Elsevier Ltd. All rights reserved.

  11. Driving Pressure Influence in Voltage Maps Measurement Process Using Advanced Pneumatic Mapping Probe

    Directory of Open Access Journals (Sweden)

    Marek Kukucka

    2016-01-01

    Full Text Available Our paper deals with the method of the voltage-impedance map measurement process as a method useful for the electric mapping of human skin. The area of research extends from the basic research to its practical application in acupuncture skin mapping and acupuncture point localization and visualization. The problem of sufficient skin coverage and electrical contact with measuring electrodes is solved by the conventional mechanical telescopic electrodes and by the pneumatic matrix electrode probe. A 2D or 3D voltage-impedance map of skin is an output of the measuring, interpretation and evaluation process. New pneumatic construction of measuring probe was implemented to achieve a better coverage of specified skin area and get a reduced force range of the touching electrodes allowing the steady contact of the skin-electrode. A skin contact is related to the driving pressure of touching electrodes. Our paper offers experimentally measured results, voltage maps of skin on specific areas, selected measured and described acupuncture points and their applications in electro-acupuncture.

  12. Lower hybrid heating and current drive, and ion cyclotron heating experiments on the Alcator C and the Versator II tokamaks

    International Nuclear Information System (INIS)

    Porkolab, M.; Blackwell, B.; Bonoli, P.

    1984-08-01

    Lower hybrid electron Landau heting experiments have been carried out on the Alcator C tokamak at densities 0.8 x 10 14 less than or equal to anti n(cm -3 ) less than or equal to 1.7 x 10 14 , and at B = 7 T - 11 T. Using SiC coated graphite limiters, upon injection of 850 kW of power at a density of anti n/sub e/ approx. = 1.3 x 10 14 cm -3 in deuterium typical temperature increases of ΔTi approx. = 0.7 keV, ΔT/sub e/ approx. = 1.0 keV were observed. Current drive and ramping experiments have also been carried out at densities 10 13 less than or equal to anti n/sub e/(cm -3 ) less than or equal to 10 14 . The maximum current drive efficiency, defined as eta = anti n(10 14 cm -3 )I(MA)R(m)/P(MW), was eta approx. = 0.12 at B = 10 T and eta approx. = 0.08 at B = 8 T. Current ramping experiments have resulted in ramping rates of ΔI/Δt approx. = 400 kA/sec with P/sub rf/ approx. = 860 kW at a density of anti n/sub e/ approx. = 3.0 x 10 13 cm -3 . Initial results from the Alcator C 180 MHz ICRF heating program are reported. Significant heating results were obtained in the hydrogen minority regime: upon injection of 400 kW of rf power the ion temperature rose by as much as 600 eV at a density of anti n/sub e/ less than or equal to 1.9 x 10 14 cm -3 . In Versator II, during lower hybrid current drive experiments the global particle confinement increased by approximately a factor of two above the ohmic discharge value when the Parail-Pogutse electron tail instability was stabilized

  13. Magnetic ripple and the modeling of lower-hybrid current drive in tokamaks

    International Nuclear Information System (INIS)

    Peysson, Y.; Arslanbekov, R.; Basiuk, V.; Carrasco, J.; Litaudon, X.; Moreau, D.; Bizarro, J.P.

    1996-01-01

    Using ray-tracing, a detailed investigation of the lower hybrid (LH) wave propagation in presence of toroidal magnetic field ripple is presented. By coupling ray tracing with a one-dimensional relativistic Fokker-Planck code, simulations of LH experiments have been performed for the Tore Supra tokamak. Taking into account magnetic ripple in LH simulations, a better agreement is found between numerical predictions and experimental observations, such as non-thermal Bremsstrahlung emission, current profile, ripple-induced power losses in local magnetic mirrors, when plasma conditions correspond to the ' 'few passes' regime. (author)

  14. Electron cyclotron heating/current-drive system using high power tubes for QUEST spherical tokamak

    Science.gov (United States)

    Onchi, Takumi; Idei, H.; Hasegawa, M.; Nagata, T.; Kuroda, K.; Hanada, K.; Kariya, T.; Kubo, S.; Tsujimura, T. I.; Kobayashi, S.; Quest Team

    2017-10-01

    Electron cyclotron heating (ECH) is the primary method to ramp up plasma current non-inductively in QUEST spherical tokamak. A 28 GHz gyrotron is employed for short pulses, where the radio frequency (RF) power is about 300 kW. Current ramp-up efficiency of 0.5 A/W has been obtained with focused beam of the second harmonic X-mode. A quasi-optical polarizer unit has been newly installed to avoid arcing events. For steady-state tokamak operation, 8.56 GHz klystron with power of 200 kW is used as the CW-RF source. The high voltage power supply (54 kV/13 A) for the klystron has been built recently, and initial bench test of the CW-ECH system is starting. The array of insulated-gate bipolar transistor works to quickly cut off the input power for protecting the klystron. This work is supported by JSPS KAKENHI (15H04231), NIFS Collaboration Research program (NIFS13KUTR085, NIFS17KUTR128), and through MEXT funding for young scientists associated with active promotion of national university reforms.

  15. FPGA-based voltage and current dual drive system for high frame rate electrical impedance tomography.

    Science.gov (United States)

    Khan, Shadab; Manwaring, Preston; Borsic, Andrea; Halter, Ryan

    2015-04-01

    Electrical impedance tomography (EIT) is used to image the electrical property distribution of a tissue under test. An EIT system comprises complex hardware and software modules, which are typically designed for a specific application. Upgrading these modules is a time-consuming process, and requires rigorous testing to ensure proper functioning of new modules with the existing ones. To this end, we developed a modular and reconfigurable data acquisition (DAQ) system using National Instruments' (NI) hardware and software modules, which offer inherent compatibility over generations of hardware and software revisions. The system can be configured to use up to 32-channels. This EIT system can be used to interchangeably apply current or voltage signal, and measure the tissue response in a semi-parallel fashion. A novel signal averaging algorithm, and 512-point fast Fourier transform (FFT) computation block was implemented on the FPGA. FFT output bins were classified as signal or noise. Signal bins constitute a tissue's response to a pure or mixed tone signal. Signal bins' data can be used for traditional applications, as well as synchronous frequency-difference imaging. Noise bins were used to compute noise power on the FPGA. Noise power represents a metric of signal quality, and can be used to ensure proper tissue-electrode contact. Allocation of these computationally expensive tasks to the FPGA reduced the required bandwidth between PC, and the FPGA for high frame rate EIT. In 16-channel configuration, with a signal-averaging factor of 8, the DAQ frame rate at 100 kHz exceeded 110 frames s (-1), and signal-to-noise ratio exceeded 90 dB across the spectrum. Reciprocity error was found to be for frequencies up to 1 MHz. Static imaging experiments were performed on a high-conductivity inclusion placed in a saline filled tank; the inclusion was clearly localized in the reconstructions obtained for both absolute current and voltage mode data.

  16. Q-profile evolution and improved core electron confinement in the full current drive operation on Tore Supra

    International Nuclear Information System (INIS)

    Litaudon, X.; Peysson, Y.; Aniel, T.; Huysmans, G.; Imbeaux, F.; Joffrin, E.; Lasalle, J.; Lotte, Ph.; Schunke, B.; Segui, J.; Tresset, G.; Zabiego, M.

    2000-12-01

    The formation of a core region with improved electron confinement is reported in the recent full current drive operation of Tore Supra where the plasma current is sustained with the Lower Hybrid, LH, wave. Current profile evolution and thermal electron transport coefficients are directly assessed using the data of the new fast electron Bremsstrahlung tomography that provides the most accurate determination of the LH current and power deposition profiles. The spontaneous rise of the core electron temperature observed a few seconds after the application of the LH power is ascribed to a bifurcation towards a state of reduced electron transport. The role of the magnetic shear is invoked to partly stabilize the anomalous electron turbulence. The electron temperature transition occurs when the q-profile evolves towards a non-inductive state with a non-monotonic shape i.e. when the magnetic shear is reduced close to zero in the plasma core. The improved core confinement phase is often terminated by a sudden MHD activity when the minimum q approaches two. (authors)

  17. Technological and physics assessments on heating and current drive systems for DEMO

    Energy Technology Data Exchange (ETDEWEB)

    Franke, Thomas, E-mail: thomas.franke@efda.org [EFDA Close Support Unit, Boltzmannstr. 2, D-85748 Garching (Germany); Max Planck Institute for Plasma Physics, Boltzmannstr. 2, D-85748 Garching (Germany); Barbato, E. [Unità Tecnica Fusione ENEA, C. R. Frascati, via E. Fermi 45, 00044 Frascati (Roma) (Italy); Bosia, G. [Department of Physics, University of Turin, Via P. Giuria 1, 10125 Turin (Italy); Cardinali, A.; Ceccuzzi, S.; Cesario, R. [Unità Tecnica Fusione ENEA, C. R. Frascati, via E. Fermi 45, 00044 Frascati (Roma) (Italy); Van Eester, D. [Laboratory for Plasma Physics, LPP-ERM/KMS, TEC & Belgian EUROfusion Consortium Partner, Brussels (Belgium); Federici, G. [EFDA Close Support Unit, Boltzmannstr. 2, D-85748 Garching (Germany); Gantenbein, G. [Karlsruhe Institute of Technology (KIT), Association EURATOM-KIT, Kaiserstrasse 12, 76131 Karlsruhe (Germany); Helou, W.; Hillairet, J. [CEA, IRFM, F-13108 Saint-Paul-lez-Durance (France); Jenkins, I. [CCFE, Culham Science Centre, Abingdon OX143DB (United Kingdom); Kazakov, Ye.O. [Laboratory for Plasma Physics, LPP-ERM/KMS, TEC & Belgian EUROfusion Consortium Partner, Brussels (Belgium); Kemp, R. [CCFE, Culham Science Centre, Abingdon OX143DB (United Kingdom); Lerche, E. [Laboratory for Plasma Physics, LPP-ERM/KMS, TEC & Belgian EUROfusion Consortium Partner, Brussels (Belgium); Mirizzi, F. [Unità Tecnica Fusione ENEA, C. R. Frascati, via E. Fermi 45, 00044 Frascati (Roma) (Italy); Noterdaeme, J.-M.; Poli, E. [Max Planck Institute for Plasma Physics, Boltzmannstr. 2, D-85748 Garching (Germany); Porte, L. [Centre de Recherches en Physique des Plasmas, Ecole Polytechnique Fédérale de Lausanne (EPFL), Station 13, CH-1015 Lausanne (Switzerland); Ravera, G.L. [Unità Tecnica Fusione ENEA, C. R. Frascati, via E. Fermi 45, 00044 Frascati (Roma) (Italy); and others

    2015-10-15

    Highlights: • Basic physics requirements of H&CD systems in DEMO have been captured. • The four H&CD systems NBI, EC, IC and LH were analysed to optimize performance. • Novel solutions were studied to overcome the limitations of the present H&CD systems. • RAMI as well as efficiency and optimized design of H&CD systems have been assessed. • Further constraints by remote maintenance or breeding blanket interactions were considered. - Abstract: The physics requirements of the heating and current (H&CD) systems in a Demonstration Fusion Power Plant (DEMO) are often beyond the actual level of design maturity and technology readiness required. The recent EU fusion roadmap advocates a pragmatic approach and favours, for the initial design integration studies, systems to be as much as possible, extrapolated from the ITER experience. To reach the goal of demonstrating the production of electricity in DEMO with a closed fuel cycle by 2050, one must ensure reliability, availability, maintainability, inspectability (RAMI) as well as performance, efficiency and optimized design for the H&CD systems. In the recent Power Plant Physics & Technology (PPP&T) Work Programme, a number of H&CD studies were performed. The four H&CD systems Neutral Beam (NB) Injection, Electron Cyclotron (EC), Ion Cyclotron (IC) and Lower Hybrid (LH) were considered. First, a physics optimization study was made assuming all technologies are available and identifying which parameters are needed to optimize the performance for given plasma parameters. Separately, the (i) technological maturity was considered (e.g. 240 GHz gyrotrons for EC) and (ii) technologies were adapted (e.g. multi-stage depressed collector for EC) or (iii) novel solutions (e.g. photo-neutralization for NB or new antennae concepts for IC) were studied to overcome the limitations of the present H&CD systems with respect to DEMO requirements. Further constraints imposed by remote maintenance or breeding blanket interactions

  18. RF high voltage performance of RF transmission line components on the DIII-D Fast Wave Current Drive (FWCD) system

    International Nuclear Information System (INIS)

    Ferguson, S.W.; Callis, R.W.; Cary, W.P.; Phelps, D.A.; Ponce, D.; Baity, F.W.; Barber, G.

    1995-01-01

    The performance of the high voltage rf components of the DIII-D Fast Wave Current Drive System (FWCD) have been evaluated under various conditions of insulator configuration, insulator material, insulating gas and gas pressure. The insulator materials that have been investigated are alumina, steatite, pyrex, quartz, and teflon. The results of this evaluation are discussed in this paper. Additionally a rf high potter was developed to aid in the evaluation of rf high voltage components. The high potter consists of a 50 Ω, 1/4 wavelength cavity with a variable position short and a 50 ohm matched tap at one end of the cavity. With this configuration rf voltages were generated in excess of 100 kVp in the frequency range 30 to 60 MHz

  19. RF high voltage performance of RF transmission line components on the DIII-D Fast Wave Current Drive (FWCD) System

    International Nuclear Information System (INIS)

    Ferguson, S.W.; Callis, R.W.; Cary, W.P.; Phelps, D.A.; Ponce, D.; Baity, F.W.; Barber, G.

    1995-12-01

    The performance of the high voltage rf components of the DIII-D Fast Wave Current Drive System (FWCD) have been evaluated under various conditions of insulator configuration, insulator material, insulating gas and gas pressure. The insulator materials that have been investigated are alumina, steatite, pyrex, quartz, and teflon. The results of this evaluation are discussed in this paper. Additionally a rf high potter was developed to aid in the evaluation of rf high voltage components. The high potter consists of a 50 Ω, 1/4 wavelength cavity with a variable position short and a 50 ohm matched tap at one end of the cavity. With this configuration rf voltages were generated in excess of 100 kVp in the frequency range 30 to 60 MHz

  20. Quasilinear description of heating and current drive in tokamaks by means of test particle Fokker-Planck equation

    International Nuclear Information System (INIS)

    Faulconer, D.W.; Evrard, M.P.

    1991-01-01

    The Fokker-Planck equation is employed to describe wave heating and current drive in fields which are strong enough to distort the zero-order velocity distribution in the face of Maxwellianization by collisions. The effect of the imposed HF wave enters this equation as an additional diffusive term alongside the usual collision term, with a diffusion coefficient, D, calculated from quasilinear theory. In order to account for the irregular motion of trapped and passing particles in a tokamak, this equation is 'bounce averaged' over this motion. Such approaches employ either of two general procedures: 1) averaging of the D which follows from locally homogeneous theory or 2) deriving D from a quasilinear theory which employs the motion of individual particles in the inhomogeneous tokamak magnetic field. Considering low collisionality, we adopt the latter approach as more fundamental in allowing retention of wave-particle phase effects which can limit heating and current drive due to the coherent HF perturbation. An earlier model of the second type which incorporates this limitation has adopted a Hamiltonian formalism, deriving D by proceeding through the Vlasov equation written in action-angle variables. In contrast to this work which uses the kinetic equation, we derive D directly, employing a test particle approach along the lines of work on electron cyclotron resonance. The full Hamiltonian formalism is not used, nor is modal decomposition of poloidal spatial dependence imposed, these points favoring adaptation to diverse field geometries and wave codes (e.g. the SPRUCE 2-D finite difference full wave code which uses Fourier analysis only in toroidal angle). (author) 3 refs

  1. [Current recommendations for basic/advanced life support : Addressing unanswered questions and future prospects].

    Science.gov (United States)

    Fink, K; Schmid, B; Busch, H-J

    2016-11-01

    The revised guidelines for cardiopulmonary resuscitation were implemented by the European Resuscitation Council (ERC) in October 2015. There were few changes concerning basic and advanced life support; however, some issues were clarified compared to the ERC recommendations from 2010. The present paper summarizes the procedures of basic and advanced life support according to the current guidelines and highlights the updates of 2015. Furthermore, the article depicts future prospects of cardiopulmonary resuscitation that may improve outcome of patients after cardiac arrest in the future.

  2. Automated driving safer and more efficient future driving

    CERN Document Server

    Horn, Martin

    2017-01-01

    The main topics of this book include advanced control, cognitive data processing, high performance computing, functional safety, and comprehensive validation. These topics are seen as technological bricks to drive forward automated driving. The current state of the art of automated vehicle research, development and innovation is given. The book also addresses industry-driven roadmaps for major new technology advances as well as collaborative European initiatives supporting the evolvement of automated driving. Various examples highlight the state of development of automated driving as well as the way forward. The book will be of interest to academics and researchers within engineering, graduate students, automotive engineers at OEMs and suppliers, ICT and software engineers, managers, and other decision-makers.

  3. submitter Direct Drive and Eddy Current Septa Magnet Designs for CERN's PSB Extraction at 2 GeV

    CERN Document Server

    Szoke, Z; Balhan, B; Baud, C; Borburgh, J; Hourican, M; Masson, T; Prost, A

    2016-01-01

    In the framework of the LIU project, new septa magnets have been designed between CERN's PS booster (PSB) extraction and PS injection. The upgraded devices are to deal with the increased beam energy from 1.4 to 2 GeV at extraction of the PSB. The direct drive recombination septa in the PSB transfer line to the PS and the eddy current PS injection septum together with a bumper at injection have been investigated using finite-element software. For the recombination magnets, an increase in magnet length is sufficient to obtain the required deflection; however, for the PS injection elements, a more novel solution is necessary to also achieve increased robustness to extend the expected lifetime of the pulsed device. The injection septum will share the same vacuum vessel with an injection bumper, and both magnets will be located adjacent to each other. The new PS injection magnet will be the first septum operated at CERN based on eddy current technology. The magnetic modeling of the devices, the comparison of the p...

  4. Direct Drive and Eddy Current Septa Magnet Designs for CERN’s PSB Extraction at 2 GeV

    CERN Multimedia

    Szoke, Zsolt; Balhan, Bruno; Baud, Cedric; Borburgh, Jan; Hourican, Michael; Masson, Thierry; Prost, Antoine

    2015-01-01

    In the framework of the LIU project, new septa magnets have been designed between CERN’s PS Booster (PSB) extraction and PS injection. The upgraded devices are to deal with the increased beam energy from 1.4 GeV to 2 GeV at extraction of the PSB. The direct drive recombination septa in the PSB transfer line to the PS, the eddy current PS injection septum together with a bumper at injection have been investigated using finite element software. For the recombination magnets an increase in magnet length is sufficient to obtain the required deflection; however, for the PS injection elements a more novel solution is necessary to also achieve increased robustness to extend the expected lifetime of the pulsed device. The injection septum will share the same vacuum vessel with an injection bumper and both magnets will be located adjacent to each other. The new PS injection magnet will be the first septum operated at CERN based on eddy current technology. The magnetic modelling of the devices, the comparison of the ...

  5. Plasma simulation by macroscale, electromagnetic particle code and its application to current-drive by relativistic electron beam injection

    International Nuclear Information System (INIS)

    Tanaka, M.; Sato, T.

    1985-01-01

    A new implicit macroscale electromagnetic particle simulation code (MARC) which allows a large scale length and a time step in multi-dimensions is described. Finite mass electrons and ions are used with relativistic version of the equation of motion. The electromagnetic fields are solved by using a complete set of Maxwell equations. For time integration of the field equations, a decentered (backward) finite differencing scheme is employed with the predictor - corrector method for small noise and super-stability. It is shown both in analytical and numerical ways that the present scheme efficiently suppresses high frequency electrostatic and electromagnetic waves in a plasma, and that it accurately reproduces low frequency waves such as ion acoustic waves, Alfven waves and fast magnetosonic waves. The present numerical scheme has currently been coded in three dimensions for application to a new tokamak current-drive method by means of relativistic electron beam injection. Some remarks of the proper macroscale code application is presented in this paper

  6. Effects of magnetized alpha particles on lower hybrid heating and current drive in a reactor grade plasma

    International Nuclear Information System (INIS)

    Pavlo, P.; Krlin, L.; Tluchor, Z.

    1991-01-01

    The results of computer simulations of lower hybrid current drive (LHCD) for ITER parameters are presented. The damping of LH waves by alpha particles due to the interaction at high cyclotron resonances is obtained by solving the 2-D Fokker-Planck equation with the corresponding quasi-linear term (FPA code). This code is incorporated into a spatially 1-D LHCD code so as to obtain radial profiles of the radiofrequency (RF) power absorbed by electrons (1-D Fokker-Planck code) and alpha particles as well as the radial profile of the driven current. One-pass absorption is assumed and verified by a detailed analysis of LH rays for an ITER-like magnetic configuration. Noticeable absorption by alpha particles is observed only below ∼ 5 GHz of the generator frequency and is still acceptable down to ∼ 3 Ghz (19% of the input power P in, with a 16% reduction of the total driven current for P in = 50 MW). Two competing quasi-linear effects influence the damping rates: the RF field reduces the slopes of the alpha particle distribution function but, since the absorption is accompanied by acceleration of groups of alpha particles above their initial velocity, the RF field also increases the number of resonant particles. Both the global results and the damping rates are compared with those obtained for unmagnetized alpha particles and with the linear approximation. For frequencies above ∼ 3 GHz, the latter approach was found to significantly overestimate the absorption by alpha particles. Some further mechanisms not included in the code but having possible effects on the interaction are also discussed. (author). 21 refs, 11 figs, 1 tab

  7. Locally Advanced Colon Cancer : Evaluation of Current Clinical Practice and Treatment Outcomes at the Population Level

    NARCIS (Netherlands)

    Klaver, Charlotte E. L.; Gietelink, Lieke; Bemelman, Willem A.; Wouters, Michel W. J. M.; Wiggers, Theo; Tollenaar, Rob A. E. M.; Tanis, Pieter J.

    Background: The goal of this study was to evaluate current clinical practice and treatment outcomes regarding locally advanced colon cancer (LACC) at the population level. Methods: Data were used from the Dutch Surgical Colorectal Audit from 2009 to 2014. A total of 34,527 patients underwent

  8. Locally Advanced Colon Cancer: Evaluation of Current Clinical Practice and Treatment Outcomes at the Population Level

    NARCIS (Netherlands)

    Klaver, Charlotte E. L.; Gietelink, Lieke; Bemelman, Willem A.; Wouters, Michel W. J. M.; Wiggers, Theo; Tollenaar, Rob A. E. M.; Tanis, Pieter J.

    2017-01-01

    Background: The goal of this study was to evaluate current clinical practice and treatment outcomes regarding locally advanced colon cancer (LACC) at the population level. Methods: Data were used from the Dutch Surgical Colorectal Audit from 2009 to 2014. A total of 34,527 patients underwent

  9. Runaway electron studies with hard x-ray and microwave diagnostics in the FT-2 lower hybrid current drive discharges

    Science.gov (United States)

    Shevelev, A. E.; Khilkevitch, E. M.; Lashkul, S. I.; Rozhdestvensky, V. V.; Pandya, S. P.; Plyusnin, V. V.; Altukhov, A. B.; Kouprienko, D. V.; Chugunov, I. N.; Doinikov, D. N.; Esipov, L. A.; Gin, D. B.; Iliasova, M. V.; Naidenov, V. O.; Polunovsky, I. A.; Sidorov, A. V.; Kiptily, V. G.

    2018-01-01

    Studies of the super-thermal and runaway electron behavior in ohmic and lower hybrid current drive FT-2 tokamak plasmas have been carried out using information obtained from measurements of hard x-ray spectra and non-thermal microwave radiation intensity at the frequency of 10 GHz and in the range of (53 ÷ 78) GHz. A gamma-ray spectrometer based on a scintillation detector with a LaBr3(Ce) crystal was used, which provides measurements at counting rates up to 107 s-1. Reconstruction of the energy distribution of RE interacting with the poloidal limiter of the tokamak chamber was made with application of the DeGaSum code. Super-thermal electrons accelerated up to 2 MeV by the LH waves at the high-frequency pumping of the plasma with low density ≤ft ~ 2  ×  1013 cm-3 and then up to 7 MeV by vortex electric field have been found. Experimental analysis of the runaway electron beam generation and evolution of their energy distribution in the FT-2 plasmas is presented in the article and compared with the numerical calculation of the maximum energy gained by runaway electrons for given plasma parameters. In addition, possible mechanisms for limiting the maximum energy gained by the runaway electrons are also calculated and described for a FT-2 plasma discharge.

  10. A distributed control system for the lower-hybrid current drive system on the Tokamak de Varennes

    International Nuclear Information System (INIS)

    Bagdoo, J.; Guay, J.M.; Chaudron, G.A.; Decoste, R.; Demers, Y.; Hubbard, A.

    1990-01-01

    An rf current drive system with an output power of 1 MW at 3.7 GHz is under development for the Tokamak de Varennes. The control system is based on an Ethernet local-area network of programmable logic controllers as front end, personal computers as consoles, and CAMAC-based DSP processors. The DSP processors ensure the PID control of the phase and rf power of each klystron, and the fast protection of high-power rf hardware, all within a 40 μs loop. Slower control and protection, event sequencing and the run-time database are provided by the programmable logic controllers, which communicate, via the LAN, with the consoles. The latter run a commercial process-control console software. The LAN protocol respects the first four layers of the ISO/OSI 802.3 standard. Synchronization with the tokamak control system is provided by commercially available CAMAC timing modules which trigger shot-related events and reference waveform generators. A detailed description of each subsystem and a performance evaluation of the system will be presented. (orig.)

  11. A distributed control system for the lower-hybrid current drive system on the Tokamak de Varennes

    Science.gov (United States)

    Bagdoo, J.; Guay, J. M.; Chaudron, G.-A.; Decoste, R.; Demers, Y.; Hubbard, A.

    1990-08-01

    An rf current drive system with an output power of 1 MW at 3.7 GHz is under development for the Tokamak de Varennes. The control system is based on an Ethernet local-area network of programmable logic controllers as front end, personal computers as consoles, and CAMAC-based DSP processors. The DSP processors ensure the PID control of the phase and rf power of each klystron, and the fast protection of high-power rf hardware, all within a 40 μs loop. Slower control and protection, event sequencing and the run-time database are provided by the programmable logic controllers, which communicate, via the LAN, with the consoles. The latter run a commercial process-control console software. The LAN protocol respects the first four layers of the ISO/OSI 802.3 standard. Synchronization with the tokamak control system is provided by commercially available CAMAC timing modules which trigger shot-related events and reference waveform generators. A detailed description of each subsystem and a performance evaluation of the system will be presented.

  12. EDITORIAL: Special section on recent progress on radio frequency heating and current drive studies in the JET tokamak Special section on recent progress on radio frequency heating and current drive studies in the JET tokamak

    Science.gov (United States)

    Ongena, Jef; Mailloux, Joelle; Mayoral, Marie-Line

    2009-04-01

    This special cluster of papers summarizes the work accomplished during the last three years in the framework of the Task Force Heating at JET, whose mission it is to study the optimisation of heating systems for plasma heating and current drive, launching and deposition questions and the physics of plasma rotation. Good progress and new physics insights have been obtained with the three heating systems available at JET: lower hybrid (LH), ion cyclotron resonance heating (ICRH) and neutral beam injection (NBI). Topics covered in the present issue are the use of edge gas puffing to improve the coupling of LH waves at large distances between the plasma separatrix and the LH launcher. Closely linked with this topic are detailed studies of the changes in LH coupling due to modifications in the scrape-off layer during gas puffing and simultaneous application of ICRH. We revisit the fundamental ICRH heating of D plasmas, include new physics results made possible by recently installed new diagnostic capabilities on JET and point out caveats for ITER when NBI is simultaneously applied. Other topics are the study of the anomalous behaviour of fast ions from NBI, and a study of toroidal rotation induced by ICRH, both again with possible implications for ITER. In finalizing this cluster of articles, thanks are due to all colleagues involved in preparing and executing the JET programme under EFDA in recent years. We want to thank the EFDA leadership for the special privilege of appointing us as Leaders or Deputies of Task Force Heating, a wonderful and hardworking group of colleagues. Thanks also to all other European and non-European scientists who contributed to the JET scientific programme, the Operations team of JET and the colleagues of the Close Support Unit (CSU). Thanks are also due to the Editors, Editorial Board and referees of Plasma Physics and Controlled Fusion together with the publishing staff of IOP Publishing who have supported and contributed substantially to

  13. A model of the plasma flow and current in Saturn's polar ionosphere under conditions of strong Dungey cycle driving

    Directory of Open Access Journals (Sweden)

    C. M. Jackman

    2006-05-01

    Full Text Available We propose a simple model of the flow and currents in Saturn's polar ionosphere. This model is motivated by theoretical reasoning, and guided quantitatively by in situ field and flow data from space missions, ground-based IR Doppler measurements, and Hubble Space Telescope images. The flow pattern consists of components which represent (1 plasma sub-corotation in the middle magnetosphere region resulting from plasma pick-up and radial transport from internal sources; (2 the Vasyliunas-cycle of internal plasma mass-loss down the magnetospheric tail at higher latitudes; and (3 the polar Dungey-cycle flow driven by the solar wind interaction. Upstream measurements of the interplanetary magnetic field (IMF indicate the occurrence of both extended low-field rarefaction intervals with essentially negligible Dungey-cycle flow, and few-day high-field compression regions in which the Dungey-cycle voltage peaks at a few hundred kV. Here we model the latter conditions when the Dungey-cycle is active, advancing on previous axi-symmetric models which may be more directly applicable to quiet conditions. For theoretical convenience the overall flow pattern is constructed by adding together two components - a purely rotational flow similar to previous axi-symmetric models, and a sun-aligned twin vortex representing the dawn-dusk asymmetry effects associated with the Vasyliunas-and Dungey-cycle flows. We calculate the horizontal ionospheric current associated with the flow and the field-aligned current from its divergence. These calculations show that a sheet of upward-directed field-aligned current flows at the boundary of open field lines which is strongly modulated in local-time by the Dungey-cycle flows. We then consider implications of the field-aligned current for magnetospheric electron acceleration and aurorae using two plasma source populations (hot outer magnetospheric electrons and cool dense magnetosheath electrons. Both sources display a strong dawn

  14. Analysis of Advanced Fuel Assemblies and Core Designs for the Current and Next Generations of LWRs

    International Nuclear Information System (INIS)

    Ragusa, Jean; Vierow, Karen

    2011-01-01

    The objective of the project is to design and analyze advanced fuel assemblies for use in current and future light water reactors and to assess their ability to reduce the inventory of transuranic elements, while preserving operational safety. The reprocessing of spent nuclear fuel can delay or avoid the need for a second geological repository in the US. Current light water reactor fuel assembly designs under investigation could reduce the plutonium inventory of reprocessed fuel. Nevertheless, these designs are not effective in stabilizing or reducing the inventory of minor actinides. In the course of this project, we developed and analyzed advanced fuel assembly designs with improved thermal transmutation capability regarding transuranic elements and especially minor actinides. These designs will be intended for use in thermal spectrum (e.g., current and future fleet of light water reactors in the US). We investigated various fuel types, namely high burn-up advanced mixed oxides and inert matrix fuels, in various geometrical designs that are compliant with the core internals of current and future light water reactors. Neutronic/thermal hydraulic effects were included. Transmutation efficiency and safety parameters were used to rank and down-select the various designs.

  15. Analysis of Advanced Fuel Assemblies and Core Designs for the Current and Next Generations of LWRs

    Energy Technology Data Exchange (ETDEWEB)

    Ragusa, Jean; Vierow, Karen

    2011-09-01

    The objective of the project is to design and analyze advanced fuel assemblies for use in current and future light water reactors and to assess their ability to reduce the inventory of transuranic elements, while preserving operational safety. The reprocessing of spent nuclear fuel can delay or avoid the need for a second geological repository in the US. Current light water reactor fuel assembly designs under investigation could reduce the plutonium inventory of reprocessed fuel. Nevertheless, these designs are not effective in stabilizing or reducing the inventory of minor actinides. In the course of this project, we developed and analyzed advanced fuel assembly designs with improved thermal transmutation capability regarding transuranic elements and especially minor actinides. These designs will be intended for use in thermal spectrum (e.g., current and future fleet of light water reactors in the US). We investigated various fuel types, namely high burn-up advanced mixed oxides and inert matrix fuels, in various geometrical designs that are compliant with the core internals of current and future light water reactors. Neutronic/thermal hydraulic effects were included. Transmutation efficiency and safety parameters were used to rank and down-select the various designs.

  16. Current status of advanced gastrointestinal endoscopy training fellowships in the United States

    Directory of Open Access Journals (Sweden)

    Stephen J Heller

    2011-01-01

    Full Text Available Stephen J Heller, Jeffrey L TokarDepartment of Medicine, Fox Chase Cancer Center, Philadelphia, PA, USAAbstract: Rapid growth in the field of advanced gastrointestinal endoscopy has led to an increase in specialized therapeutic endoscopy fellowships. The cornerstones of these programs are training in endoscopic retrograde cholangiopancreatography (ERCP and endoscopic ultrasound. These procedures are more complex and challenging to master than routine colonoscopy and upper endoscopy, and in the case of ERCP, higher risk. The concentration of the educational experience in the hands of relatively fewer trainees with specialized interest in advanced endoscopy has resulted in providing a focused cohort of graduating fellows with higher case volumes in training, which likely enhances diagnostic and therapeutic success and safer performance of these procedures. Endoscopic simulators, although not currently in widespread use, have the potential to improve advanced procedural training without jeopardizing patient safety.Keywords: gastrointestinal endoscopy, training, procedures, safety 

  17. IMS advances in studies of field-aligned currents and their related electrodynamics

    Energy Technology Data Exchange (ETDEWEB)

    Kamide, Y.

    1985-12-01

    During the IMS period, there have been major advances in four areas regarding field-aligned currents which directly reflect the electrical coupling between the magnetosphere and the ionosphere. First, the spatial distribution of the large-scale field-aligned currents (in particular, their average configuration) has been extensively examined with respect to IMF (interplanetary magnetic field) parameters. The role of the field-aligned currents in the dayside polar cap including their IMF B/sub y/ dependence and seasonal dependence has been cleared to some extent. It remains to be answered, however, if the substorm pattern differs uniquely from the average disturbed pattern. Second, the three-dimensional current system has been studied by using satellite and ground-based, as well as radar, measurements. The nature of the substorm current system, which changes quite dynamically depending upon the different substorm phases as well as upon different auroral forms, has been more clearly defined. A third major advance has been in the efforts to find the relative location of the field-aligned currents to various ionospheric parameters, such as electric fields, conductivities, and discrete and diffuse auroras. Finally, numerical simulations of assumptions have increasingly become a powerful tool for the study of the dynamics of the magnetosphere-ionosphere system. It appears that the large-scale characteristics of the system under steady state conditions are known in the sense that the measured key parameters are mutually consistent for average data sets.

  18. Study on fundamental mechanism of nuclear advanced robot. Some consideration of driving mechanism on remotely operated and submerged vehicle using the maintenance for nuclear power plant

    International Nuclear Information System (INIS)

    Ohki, Arahiko; Hirano, Sigeo; Oogihara, Hirotugu

    1998-01-01

    A propulsion system of fish was studied as a research of the driving mechanism of robot for nuclear maintenance in water. Fish sailing with higher speed than a constant value can sail by an Ostraciform type swimming method. Fish can advance by a winding actuation. The movement of fishes trunk and caudal at the stationary movement was studied in this paper. The hypothetical formulae of movement were constructed on the basis of the movements of trunk and caudal. The elements related to the driving force were analysed and evaluated. Then, a model for reproducing the movement was designed. The movement of model was tested. The theoretical formula proved that the driving forces were consisted of the force vectors in the forward direction to be generated by the phase differences of each points of trunk and caudal in their cyclic movements. (S.Y.)

  19. Neurogenic thoracic outlet syndrome: current diagnostic criteria and advances in MRI diagnostics.

    Science.gov (United States)

    Magill, Stephen T; Brus-Ramer, Marcel; Weinstein, Philip R; Chin, Cynthia T; Jacques, Line

    2015-09-01

    Neurogenic thoracic outlet syndrome (nTOS) is caused by compression of the brachial plexus as it traverses from the thoracic outlet to the axilla. Diagnosing nTOS can be difficult because of overlap with other complex pain and entrapment syndromes. An nTOS diagnosis is made based on patient history, physical exam, electrodiagnostic studies, and, more recently, interpretation of MR neurograms with tractography. Advances in high-resolution MRI and tractography can confirm an nTOS diagnosis and identify the location of nerve compression, allowing tailored surgical decompression. In this report, the authors review the current diagnostic criteria, present an update on advances in MRI, and provide case examples demonstrating how MR neurography (MRN) can aid in diagnosing nTOS. The authors conclude that improved high-resolution MRN and tractography are valuable tools for identifying the source of nerve compression in patients with nTOS and can augment current diagnostic modalities for this syndrome.

  20. Experimental characterization and modelling of non-linear coupling of the lower hybrid current drive power on Tore Supra

    International Nuclear Information System (INIS)

    Preynas, M.; Goniche, M.; Hillairet, J.; Litaudon, X.; Ekedahl, A.; Colas, L.

    2013-01-01

    To achieve steady-state operation on future fusion devices, in particular on ITER, the coupling of the lower hybrid wave must be optimized on a wide range of edge conditions. However, under some specific conditions, deleterious effects on the lower hybrid current drive (LHCD) coupling are sometimes observed on Tore Supra. In this way, dedicated LHCD experiments have been performed using the LHCD system of Tore Supra, composed of two different conceptual designs of launcher: the fully active multi-junction (FAM) and the new passive active multi-junction (PAM) antennas. A non-linear interaction between the electron density and the electric field has been characterized in a thin plasma layer in front of the two LHCD antennas. The resulting dependence of the power reflection coefficient (RC) with the LHCD power is not predicted by the standard linear theory of the LH wave coupling. A theoretical model is suggested to describe the non-linear wave–plasma interaction induced by the ponderomotive effect and implemented in a new full wave LHCD code, PICCOLO-2D (ponderomotive effect in a coupling code of lower hybrid wave-2D). The code self-consistently treats the wave propagation in the antenna vicinity and its interaction with the local edge plasma density. The simulation reproduces very well the occurrence of a non-linear behaviour in the coupling observed in the LHCD experiments. The important differences and trends between the FAM and the PAM antennas, especially a larger increase in RC for the FAM, are also reproduced by the PICCOLO-2D simulation. The working hypothesis of the contribution of the ponderomotive effect in the non-linear observations of LHCD coupling is therefore validated through this comprehensive modelling for the first time on the FAM and PAM antennas on Tore Supra. (paper)

  1. High speed control of electro-mechanical transduction Advanced Drive Techniques for Optimized Step-and-Settle Response of MEMS Micromirrors

    OpenAIRE

    Imboden, Matthias; Chang, Jackson; Pollock, Corey; Lowell, Evan; Akbulut, Mehmet; Morrison, Jessica; Stark, Thomas; Bifano, Thomas G.; Bishop, David J.

    2015-01-01

    Micro/Nano Electro Mechanical Systems (MEMS/NEMS) provide the engineer with a powerful set of solutions to a wide variety of technical challenges. However, because they are mechanical systems, response times can be a limitation. In some situations, advanced engineered drive techniques can improve response times by as much as a thousand, significantly opening up the application space for MEMS/NEMS solutions.

  2. Advances based on digital technology named TEDDY+ for inspection of eddy current

    International Nuclear Information System (INIS)

    Barcenilla, V.; Hernandez, J.; Ribes, B.

    2007-01-01

    As a result of the recent developing line of eddy current data acquisition system a new product based on digital technology named TEDDY+, comes to the market. With only 4 kg of weight constitutes a great advance with regards to other equipment's available in the market. These advances, have enabled, among others, to increase considerably the signal to noise (S/N) ratio, avoid typical saturation problems in the eddy current signal, increase the inspection speed, eliminate the reference probe, detect the air/tube signal in real time, and the possibility to integrate the tester inside a push puller thanks to its reduced size and to have integrated as part of the ET equipment the mechanical systems control board. Two product lines have been developed, one oriented to any market and application (nuclear market, industrial and aeronautical, chemical and petrochemical, etc) and other specially dedicated to the massive inspection of tubes, named TEDDY+SP (Suitcase Pusher). Both lines are prepared to use eddy current arrays which clearly constitute the future of the eddy current inspection systems. The new TEDDY+ line of products presented in this paper constitutes one of the most powerful and reliable existing in the market. These improvements and novelties place the new ET inspection system from Tecnatom as one of the most powerful and reliable in the market. (Author)

  3. Warfighter nutrition: current opportunities and advanced technologies report from a Department of Defense workshop.

    Science.gov (United States)

    Deuster, Patricia A; Weinstein, Ali A; Sobel, Annette; Young, Andrew J

    2009-07-01

    The Uniformed Services University hosted a conference in July 2008 entitled "Warfighter Nutrition: Advanced Technologies and Opportunities" with Health Affairs and the Defense Advanced Research Projects Agency to develop strategic and tactical plans that could enhance Force Health Protection (FHP) by optimizing warfighter nutrition within the Department of Defense (DoD). The conference focused on three aspects of military nutrition: (1) fueling the forces, or garrison feeding; (2) performance optimization or operational feeding during deployment; and (3) nutritional interventions to support health reset and healing. Presentations by speakers addressed practical interventions (i.e., ready for implementation now) and advanced technologies (i.e., approaches meriting prioritized research and development efforts to transition into application). The conference concluded that nutritional optimization represents an integral and proactive approach to prevent illness, injury, and performance degradation throughout all phases of military service. The overarching consensus achieved was that warfighter nutrition, as a cornerstone of FHP, warrants the critical attention of both medical and line leadership to move quickly to support current initiatives and future advanced technologies.

  4. Current status of environmental, health, and safety issues of electrochemical capacitors for advanced vehicle applications

    Energy Technology Data Exchange (ETDEWEB)

    Vimmerstedt, L J; Hammel, C J

    1997-04-01

    Electrochemical capacitors are a candidate for traction power assists in hybrid electric vehicles (HEVs). Other advanced automotive applications, while not the primary focus of current development efforts, are also possible. These include load leveling high-energy batteries, power conditioning electronics, electrically hated catalysts, electric power steering, and engine starter power. Higher power and longer cycle life are expected for electrochemical capacitors than for batteries. Evaluation of environmental, health, and safety (EH and S) issues of electrochemical capacitors is an essential part of the development and commercialization of electrochemical capacitors for advanced vehicles. This report provides an initial EH and S assessment. This report presents electrochemical capacitor electrochemistry, materials selection, intrinsic material hazards, mitigation of those hazards, environmental requirements, pollution control options, and shipping requirements. Most of the information available for this assessment pertains to commercial devices intended for application outside the advanced vehicle market and to experiment or prototype devices. Electrochemical capacitors for power assists in HEVs are not produced commercially now. Therefore, materials for advanced vehicle electrochemical capacitors may change, and so would the corresponding EH and S issues. Although changes are possible, this report describes issues for likely electrochemical capacitor designs.

  5. Human immune responses against Shigella and enterotoxigenic E. coli: Current advances and the path forward.

    Science.gov (United States)

    McArthur, Monica A; Maciel, Milton; Pasetti, Marcela F

    2017-12-14

    Robust and well-established immunological assays and firm immune correlates of protection that can predict disease outcome and/or vaccine efficacy are essential to adequately assess human immune responses to infection and vaccination. The availability of reagents and calibrated controls is also critically important to standardize assays and generate comparable results among different laboratories. The workshop "Human Immune Responses against Shigella and ETEC: Current Advances and the Path Forward" held during the VASE meeting provided an opportunity to disseminate and discuss recent advances in the field of Shigella and ETEC immunology, identify research needs, and propose collaborative activities to advance the field. Four presentations featured current knowledge on humoral and cellular immune responses to Shigella and ETEC during infection and vaccination. A discussion followed on immunological methods relevant for clinical studies, immune parameters associated with protection, harmonization of assays among laboratories, and availability of reagents and standards. Specific recommendations proposed to facilitate "the path forward" included supporting communication among scientists, harmonization of assays and sharing of protocols, the creation of a repository of reagents and calibrated controls and distribution of such material to the research community, and expansion of exploratory studies to better understand the interactions between these pathogens and the human immune system and the ensuing responses. Copyright © 2017. Published by Elsevier Ltd.

  6. Improved current-regulated delta modulator for reducing switching frequency and low-frequency current error in permanent magnet brushless AC drives \\ud

    OpenAIRE

    Wipasuramonton, P.; Zhu, Z.Q.; Howe, D.

    2005-01-01

    The conventional current-regulated delta modulator (CRDM) results in a high current ripple and a high switching frequency at low rotational speeds, and in low-frequency current harmonics, including a fundamental current error, at high rotational speeds. An improved current controller based on CRDM is proposed which introduces a zero-vector zone and a current error correction technique. It reduces the current ripple and switching frequency at low speeds, without the need to detect the back-emf...

  7. Design of the beam shut-off current monitor upgrade for the Advanced Photon Source

    International Nuclear Information System (INIS)

    Pietryla, A.; Decker, G.

    2000-01-01

    Plans to eliminate the positron accumulator ring (PAR) from the Advanced Photon Source (APS) injector complex have created the need for a device to limit the allowable beam charge injected into the APS injector synchrotrons. The beam shut-off current monitor (BESOCM) was chosen to provide this function. This new application of the BESOCM provided the opportunity to explore new design philosophies. Two design goals were to de-emphasize reliance on external signals and to become insensitive to timing variations. Both of these goals were accomplished by deriving the trigger directly from the beam. This paper will discuss the features of the new BESOCM design and present data demonstrating its function

  8. Advanced alarm system design and human performance: Guidance development and current research

    International Nuclear Information System (INIS)

    O'Hara, J.M.

    1997-01-01

    This paper describes a research program sponsored by the U.S. Nuclear Regulatory Commission to address the human factors engineering (HFE) aspects of nuclear power plant alarm systems. The overall objective of the program is to develop HFE review guidance for advanced alarm systems. Guidance has been developed based on a broad base of technical and research literature. As part of the development effort, aspects of alarm system design for which the technical basis was insufficient to support guidance development were identified and prioritized. Research is currently underway to address the highest priority topics: alarm processing and display characteristics. (author). 29 refs, 2 figs

  9. Electric Drive Dynamic Thermal System Model for Advanced Vehicle Propulsion Technologies: Cooperative Research and Development Final Report, CRADA Number CRD-09-360

    Energy Technology Data Exchange (ETDEWEB)

    Bennion, K. [National Renewable Energy Lab. (NREL), Golden, CO (United States)

    2013-10-01

    Electric drive systems, which include electric machines and power electronics, are a key enabling technology for advanced vehicle propulsion systems that reduce the dependence of the U.S. transportation sector on petroleum. However, to penetrate the market, these electric drive technologies must enable vehicle solutions that are economically viable. The push to make critical electric drivesystems smaller, lighter, and more cost-effective brings respective challenges associated with heat removal and system efficiency. In addition, the wide application of electric drive systems to alternative propulsion technologies ranging from integrated starter generators, to hybrid electric vehicles, to full electric vehicles presents challenges in terms of sizing critical components andthermal management systems over a range of in-use operating conditions. This effort focused on developing a modular modeling methodology to enable multi-scale and multi-physics simulation capabilities leading to generic electric drive system models applicable to alternative vehicle propulsion configurations. The primary benefit for the National Renewable Energy Laboratory (NREL) is the abilityto define operating losses with the respective impact on component sizing, temperature, and thermal management at the component, subsystem, and system level. However, the flexible nature of the model also allows other uses related to evaluating the impacts of alternative component designs or control schemes depending on the interests of other parties.

  10. Current advances and trends in electro-Fenton process using heterogeneous catalysts - A review.

    Science.gov (United States)

    Poza-Nogueiras, Verónica; Rosales, Emilio; Pazos, Marta; Sanromán, M Ángeles

    2018-06-01

    Over the last decades, advanced oxidation processes have often been used alone, or combined with other techniques, for remediation of ground and surface water pollutants. The application of heterogeneous catalysis to electrochemical advanced oxidation processes is especially useful due to its efficiency and environmental safety. Among those processes, electro-Fenton stands out as the one in which heterogeneous catalysis has been broadly applied. Thus, this review has introduced an up-to-date collation of the current knowledge of the heterogeneous electro-Fenton process, highlighting recent advances in the use of different catalysts such as iron minerals (pyrite, magnetite or goethite), prepared catalysts by the load of metals in inorganic and organic materials, nanoparticles, and the inclusion of catalysts on the cathode. The effects of physical-chemical parameters as well as the mechanisms involved are critically assessed. Finally, although the utilization of this process to remediation of wastewater overwhelmingly outnumber other utilities, several applications have been described in the context of regeneration of adsorbent or the remediation of soils as clear examples of the feasibility of the electro-Fenton process to solve different environmental problems. Copyright © 2018 Elsevier Ltd. All rights reserved.

  11. Advances in Wound Healing: A Review of Current Wound Healing Products

    Directory of Open Access Journals (Sweden)

    Patrick S. Murphy

    2012-01-01

    Full Text Available Successful wound care involves optimizing patient local and systemic conditions in conjunction with an ideal wound healing environment. Many different products have been developed to influence this wound environment to provide a pathogen-free, protected, and moist area for healing to occur. Newer products are currently being used to replace or augment various substrates in the wound healing cascade. This review of the current state of the art in wound-healing products looks at the latest applications of silver in microbial prophylaxis and treatment, including issues involving resistance and side effects, the latest uses of negative pressure wound devices, advanced dressings and skin substitutes, biologic wound products including growth factor applications, and hyperbaric oxygen as an adjunct in wound healing. With the abundance of available products, the goal is to find the most appropriate modality or combination of modalities to optimize healing.

  12. Safety design features for current UK advanced gas-cooled reactors

    International Nuclear Information System (INIS)

    Yellowlees, J.M.; Cobb, E.C.

    1981-01-01

    The nuclear power stations planned for Heysham II and Torness will each have twin 660 MW(e) Advanced Gas-cooled Reactors (AGR) based on the design of those which have been operating at Hinkley Point 'B' and Hunterston 'B' since 1976. This paper has described the way in which the shutdown and cooling systems for the Heysham II and Torness AGRs have been selected in order to meet current UK safety requirements. Fault tree analyses have been used to identify the credible fault sequences, the probabilities of which have been calculated. By this means the relative importance of the various protective systems has been established and redundancy and reliability requirements identified. This systematic approach has led to a balanced design giving protection over the complete spectrum of fault sequences. Current safety requirements for thermal reactors in the UK and particular requirements in the design of the Heysham II and Torness reactors are discussed

  13. Whistlers, helicons, and lower hybrid waves: The physics of radio frequency wave propagation and absorption for current drive via Landau damping

    International Nuclear Information System (INIS)

    Pinsker, R. I.

    2015-01-01

    This introductory-level tutorial article describes the application of plasma waves in the lower hybrid range of frequencies (LHRF) for current drive in tokamaks. Wave damping mechanisms in a nearly collisionless hot magnetized plasma are briefly described, and the connections between the properties of the damping mechanisms and the optimal choices of wave properties (mode, frequency, wavelength) are explored. The two wave modes available for current drive in the LHRF are described and compared. The terms applied to these waves in different applications of plasma physics are elucidated. The character of the ray paths of these waves in the LHRF is illustrated in slab and toroidal geometries. Applications of these ideas to experiments in the DIII-D tokamak are discussed

  14. Modulation method for a multiple drive system based on a two-stage direct power conversion topology with reduced input current ripple

    DEFF Research Database (Denmark)

    Klumpner, Christian; Blaabjerg, Frede

    2005-01-01

    A new two-stage multi-drive direct power conversion (DPC) topology suited for multi-drive application is proposed, having an input port for a three-phase power supply and several output ports to connect three-phase loads, which are independently controlled and allow for sine wave in-sine wave out...... operation. This is a cost effective topology compared to a standard matrix converter because the multiple three-phase loads share the cost of the controlled rectification stage. A new method to reduce the high frequency ripple from the input current is also proposed based on interleaving the switching...... patterns of the inversion stages, which have to form two groups, allowing for size reduction of the input current filter. This is validated by experiments on a realistic laboratory prototype, while its limitations are determined by simulations....

  15. Corneal stem cells and tissue engineering: Current advances and future perspectives.

    Science.gov (United States)

    de Araujo, Aline Lütz; Gomes, José Álvaro Pereira

    2015-06-26

    Major advances are currently being made in regenerative medicine for cornea. Stem cell-based therapies represent a novel strategy that may substitute conventional corneal transplantation, albeit there are many challenges ahead given the singularities of each cellular layer of the cornea. This review recapitulates the current data on corneal epithelial stem cells, corneal stromal stem cells and corneal endothelial cell progenitors. Corneal limbal autografts containing epithelial stem cells have been transplanted in humans for more than 20 years with great successful rates, and researchers now focus on ex vivo cultures and other cell lineages to transplant to the ocular surface. A small population of cells in the corneal endothelium was recently reported to have self-renewal capacity, although they do not proliferate in vivo. Two main obstacles have hindered endothelial cell transplantation to date: culture protocols and cell delivery methods to the posterior cornea in vivo. Human corneal stromal stem cells have been identified shortly after the recognition of precursors of endothelial cells. Stromal stem cells may have the potential to provide a direct cell-based therapeutic approach when injected to corneal scars. Furthermore, they exhibit the ability to deposit organized connective tissue in vitro and may be useful in corneal stroma engineering in the future. Recent advances and future perspectives in the field are discussed.

  16. Current status of selected oral peptide technologies in advanced preclinical development and in clinical trials.

    Science.gov (United States)

    Aguirre, T A S; Teijeiro-Osorio, D; Rosa, M; Coulter, I S; Alonso, M J; Brayden, D J

    2016-11-15

    The development of oral dosage forms that allows absorption of therapeutic peptides to the systemic circulation is one of the greatest challenges for the pharmaceutical industry. Currently, a number of technologies including either mixtures of penetration enhancers or protease inhibitors and/or nanotechnology-based products are under clinical development. Typically, these formulations are presented in the form of enteric-coated tablets or capsules. Systems undergoing preclinical investigation include further advances in nanotechnology, including intestinal microneedle patches, as well as their combination with regional delivery to the colon. This review critically examines four selected promising oral peptide technologies at preclinical stage and the twelve that have progressed to clinical trials, as indicated in www.clinicaltrials.gov. We examined these technologies under the criteria of peptide selection, formulation design, system components and excipients, intestinal mechanism of action, efficacy in man, and safety issues. The conclusion is that most of the technologies in clinical trials are incremental rather than paradigm-shifting and that even the more clinically advanced oral peptide drugs examples of oral bioavailability appear to yield oral bioavailability values of only 1-2% and are, therefore, only currently suitable for a limited range of peptides. Copyright © 2016 Elsevier B.V. All rights reserved.

  17. JSC Advanced Curation: Research and Development for Current Collections and Future Sample Return Mission Demands

    Science.gov (United States)

    Fries, M. D.; Allen, C. C.; Calaway, M. J.; Evans, C. A.; Stansbery, E. K.

    2015-01-01

    Curation of NASA's astromaterials sample collections is a demanding and evolving activity that supports valuable science from NASA missions for generations, long after the samples are returned to Earth. For example, NASA continues to loan hundreds of Apollo program samples to investigators every year and those samples are often analyzed using instruments that did not exist at the time of the Apollo missions themselves. The samples are curated in a manner that minimizes overall contamination, enabling clean, new high-sensitivity measurements and new science results over 40 years after their return to Earth. As our exploration of the Solar System progresses, upcoming and future NASA sample return missions will return new samples with stringent contamination control, sample environmental control, and Planetary Protection requirements. Therefore, an essential element of a healthy astromaterials curation program is a research and development (R&D) effort that characterizes and employs new technologies to maintain current collections and enable new missions - an Advanced Curation effort. JSC's Astromaterials Acquisition & Curation Office is continually performing Advanced Curation research, identifying and defining knowledge gaps about research, development, and validation/verification topics that are critical to support current and future NASA astromaterials sample collections. The following are highlighted knowledge gaps and research opportunities.

  18. Does knowledge of teen driving risks and awareness of current law translate into support for stronger GDL provisions? Lessons learned from one state.

    Science.gov (United States)

    Campbell, Brendan T; Chaudhary, Neil K; Saleheen, Hassan; Borrup, Kevin; Lapidus, Garry

    2009-08-01

    Many states are considering strengthening their graduated driving licensing (GDL) systems for teenage drivers but most do not know the level of public support for proposed upgrades. This study provides a method for states to identify specific demographic groups that may differ with regard to their awareness of teen driving risks, knowledge of current GDL law, and support for GDL upgrades. A 28-item questionnaire was administered to Connecticut adults by phone survey during January 2008. We collected demographic information and whether respondents understood driving risks, were aware of the current GDL system, and whether they would support GDL upgrades. The state's motor vehicle crash file (1999-2006) was used to calculate motor vehicle crash rate among 16- and 17-year-old drivers by town and correlate that with support for GDL upgrades. Eight hundred seven people were interviewed. More women than men (92% vs. 86%, p towns (38%). Two thirds supported a passenger restriction upgrade with no differences based upon sex or geographic location. There was less support for an increased penalties in Fairfield County when compared to all other counties (55% vs. 63%, p County versus all other counties (70% vs. 58%, p < .05). Parents of Connecticut teens were more knowledgeable of current law but less supportive of GDL upgrades compared to other adults. Women were more apt to favor GDL upgrades than men. This study identifies subgroups that can be targeted for prevention activities and illustrates a useful method to assess public support for GDL upgrades.

  19. Fundamental analysis and development of the current and voltage control method by changing the driving frequency for the transcutaneous energy transmission system.

    Science.gov (United States)

    Miura, Hidekazu; Yamada, Akihiro; Shiraishi, Yasuyuki; Yambe, Tomoyuki

    2015-08-01

    We have been developing transcutaneous energy transmission system (TETS) for a ventricular assist device, shape memory alloy (SMA) fibered artificial organs and so on, the system has high efficiency and a compact size. In this paper, we summarize the development, design method and characteristics of the TETS. New control methods for stabilizing output voltage or current of the TETS are proposed. These methods are primary side, are outside of the body, not depending on a communication system from the inside the body. Basically, the TETS operates at the fixed frequency with a suitable compensation capacitor so that the internal impedance is minimalized and a flat load characteristic is obtained. However, when the coil shifted from the optimal position, the coupling factor changes and the output is fluctuated. TETS has a resonant property; its output can be controlled by changing the driving frequency. The continuous current to continuous voltage driving method was implemented by changing driving frequency and setting of limitation of low side frequency. This method is useful for battery charging system for electrically driven artificial hearts and also useful for SMA fibered artificial organs which need intermittent high peak power comsumption. In this system, the internal storage capacitor is charged slowly while the fibers are turned off and discharge the energy when the fibers are turned on. We examined the effect of the system. It was found that the size and maximum output of the TETS would able to be reduced.

  20. Failure of the Current Advance Care Planning Paradigm: Advocating for a Communications-Based Approach.

    Science.gov (United States)

    Vearrier, Laura

    2016-12-01

    The purpose of advance care planning (ACP) is to allow an individual to maintain autonomy in end-of-life (EOL) medical decision-making even when incapacitated by disease or terminal illness. The intersection of EOL medical technology, ethics of EOL care, and state and federal law has driven the development of the legal framework for advance directives (ADs). However, from an ethical perspective the current legal framework is inadequate to make ADs an effective EOL planning tool. One response to this flawed AD process has been the development of Physician Orders for Life Sustaining Treatment (POLST). POLST has been described as a paradigm shift to address the inadequacies of ADs. However, POLST has failed to bridge the gap between patients and their autonomous, preferred EOL care decisions. Analysis of ADs and POLST reveals that future policy should focus on a communications-based approach to ACP that emphasizes ongoing interactions between healthcare providers and patients to optimize EOL medical care to the individual patient.

  1. An eddy-current model for three-dimensional nondestructive evaluation of advanced composites

    Science.gov (United States)

    Sabbagh, Harold A.; Murphy, R. Kim; Sabbagh, Elias H.

    2015-03-01

    We have developed a rigorous electromagnetic model and an inversion algorithm for the three-dimensional NDE of advanced composite materials. This approach extends Victor Technologies' work in eddy-current NDE of conventional metals, and allows one to determine in localized regions the fiber-resin ratio in graphite-epoxy, and to determine those anomalies, e.g., delaminations, broken fibers, moisture content, etc., that can be reconstructed by our inversion method. In developing the model, we apply rigorous electromagnetic theory to determine a Green's function for a slab of anisotropic composite material, and then determine the integral relations for the forward and inverse problems using the Green's function. We will give examples of the solution of forward problems using this model.

  2. Advances for prosthetic technology from historical perspective to current status to future application

    CERN Document Server

    LeMoyne, Robert

    2016-01-01

    This book focuses on the advances in transtibial prosthetic technology and targets research in the evolution of the powered prosthesis such as the BiOM, which was derived from considerable research and development at the Massachusetts Institute of Technology. The concept of the book spans the historical evolution of prosthetic applications from passive to new and futuristic robotic prosthetic technologies.  The author describes the reasons for amputation, surgical procedures, and an historical perspective of the prosthesis for the lower limb. He also addresses the phases and sub-phases of gait and compensatory mechanisms arising for a transtibial prosthesis and links the compensatory mechanisms to long-term morbidities.  The general technologies for gait analysis central to prosthetic design and the inherent biomechanics foundations for analysis are also explored.  The book reports on recent-past to current-term applications with passive elastic prostheses.  The core of the book deals with futuristic robo...

  3. Current Animal Models of Postoperative Spine Infection and Potential Future Advances

    Directory of Open Access Journals (Sweden)

    Alexandra eStavrakis

    2015-05-01

    Full Text Available Implant related infection following spine surgery is a devastating complication for patients and can potentially lead to significant neurological compromise, disability, morbidity, and even mortality. This paper provides an overview of the existing animal models of postoperative spine infection and highlights the strengths and weaknesses of each model. In addition there is discussion regarding potential modifications to these animal models to better evaluate preventative and treatment strategies for this challenging complication. Current models are effective in simulating surgical procedures but fail to evaluate infection longitudinally using multiple techniques. Potential future modifications to these models include using advanced imaging technologies to evaluate infection, use of bioluminescent bacterial species, and testing of novel treatment strategies against multiple bacterial strains. There is potential to establish a postoperative spine infection model using smaller animals, such as mice, as these would be a more cost-effective screening tool for potential therapeutic interventions.

  4. Current Advancements and Strategies in Tissue Engineering for Wound Healing: A Comprehensive Review.

    Science.gov (United States)

    Ho, Jasmine; Walsh, Claire; Yue, Dominic; Dardik, Alan; Cheema, Umber

    2017-06-01

    Significance: With an aging population leading to an increase in diabetes and associated cutaneous wounds, there is a pressing clinical need to improve wound-healing therapies. Recent Advances: Tissue engineering approaches for wound healing and skin regeneration have been developed over the past few decades. A review of current literature has identified common themes and strategies that are proving successful within the field: The delivery of cells, mainly mesenchymal stem cells, within scaffolds of the native matrix is one such strategy. We overview these approaches and give insights into mechanisms that aid wound healing in different clinical scenarios. Critical Issues: We discuss the importance of the biomimetic niche, and how recapitulating elements of the native microenvironment of cells can help direct cell behavior and fate. Future Directions: It is crucial that during the continued development of tissue engineering in wound repair, there is close collaboration between tissue engineers and clinicians to maintain the translational efficacy of this approach.

  5. GRAPEVINE VIRUS DISEASES:ECONOMIC IMPACT AND CURRENT ADVANCES IN VIRAL PROSPECTION AND MANAGEMENT

    Directory of Open Access Journals (Sweden)

    MARCOS FERNANDO BASSO

    Full Text Available ABSTRACT Grapevine (Vitis spp. is a major vegetative propagated fruit crop with high socioeconomic importance worldwide. It is susceptible to several graft-transmitted agents that cause several diseases and substantial crop losses, reducing fruit quality and plant vigor, and shorten the longevity of vines. The vegetative propagation and frequent exchanges of propagative material among countries contribute to spread these pathogens, favoring the emergence of complex diseases. Its perennial life cycle further accelerates the mixing and introduction of several viral agents into a single plant. Currently, approximately 65 viruses belonging to different families have been reported infecting grapevines, but not all cause economically relevant diseases. The grapevine leafroll, rugose wood complex, leaf degeneration and fleck diseases are the four main disorders having worldwide economic importance. In addition, new viral species and strains have been identified and associated with economically important constraints to grape production. In Brazilian vineyards, eighteen viruses, three viroids and two virus-like diseases had already their occurrence reported and were molecularly characterized. Here, we review the current knowledge of these viruses, report advances in their diagnosis and prospection of new species, and give indications about the management of the associated grapevine diseases.

  6. Current Advance and Future Prospects of Tissue Engineering Approach to Dentin/Pulp Regenerative Therapy

    Directory of Open Access Journals (Sweden)

    Ting Gong

    2016-01-01

    Full Text Available Recent advances in biomaterial science and tissue engineering technology have greatly spurred the development of regenerative endodontics. This has led to a paradigm shift in endodontic treatment from simply filling the root canal systems with biologically inert materials to restoring the infected dental pulp with functional replacement tissues. Currently, cell transplantation has gained increasing attention as a scientifically valid method for dentin-pulp complex regeneration. This multidisciplinary approach which involves the interplay of three key elements of tissue engineering—stem cells, scaffolds, and signaling molecules—has produced an impressive number of favorable outcomes in preclinical animal studies. Nevertheless, many practical hurdles need to be overcome prior to its application in clinical settings. Apart from the potential health risks of immunological rejection and pathogenic transmission, the lack of a well-established banking system for the isolation and storage of dental-derived stem cells is the most pressing issue that awaits resolution and the properties of supportive scaffold materials vary across different studies and remain inconsistent. This review critically examines the classic triad of tissue engineering utilized in current regenerative endodontics and summarizes the possible techniques developed for dentin/pulp regeneration.

  7. Current Advance and Future Prospects of Tissue Engineering Approach to Dentin/Pulp Regenerative Therapy

    Science.gov (United States)

    Gong, Ting; Heng, Boon Chin; Lo, Edward Chin Man; Zhang, Chengfei

    2016-01-01

    Recent advances in biomaterial science and tissue engineering technology have greatly spurred the development of regenerative endodontics. This has led to a paradigm shift in endodontic treatment from simply filling the root canal systems with biologically inert materials to restoring the infected dental pulp with functional replacement tissues. Currently, cell transplantation has gained increasing attention as a scientifically valid method for dentin-pulp complex regeneration. This multidisciplinary approach which involves the interplay of three key elements of tissue engineering—stem cells, scaffolds, and signaling molecules—has produced an impressive number of favorable outcomes in preclinical animal studies. Nevertheless, many practical hurdles need to be overcome prior to its application in clinical settings. Apart from the potential health risks of immunological rejection and pathogenic transmission, the lack of a well-established banking system for the isolation and storage of dental-derived stem cells is the most pressing issue that awaits resolution and the properties of supportive scaffold materials vary across different studies and remain inconsistent. This review critically examines the classic triad of tissue engineering utilized in current regenerative endodontics and summarizes the possible techniques developed for dentin/pulp regeneration. PMID:27069484

  8. A robust predictive current controller for healthy and open-circuit faulty conditions of five-phase BLDC drives applicable for wind generators and electric vehicles

    International Nuclear Information System (INIS)

    Salehi Arashloo, Ramin; Salehifar, Mehdi; Romeral, Luis; Sala, Vicent

    2015-01-01

    Highlights: • Model predictive deadbeat control of generator stator phase currents. • Fault tolerant control of five-phase BLDC generator. • Control of stator phase currents under normal and open-circuit faulty conditions. • MATLAB simulation and experimental verification of proposed control method. • Verification of robustness and fast respond of proposed controlling method. - Abstract: Fault tolerant control of five-phase brushless direct current (BLDC) machines is gaining more importance in high-safety applications such as offshore wind generators and automotive industries. In many applications, traditional controllers (such as PI controllers) are used to control the stator currents under faulty conditions. These controllers have good performance with dc signals. However, in the case of missing one or two of the phases, appropriate reference currents of these machines have oscillatory dynamics both in phase- and synchronous-reference frames. Non-constant nature of these reference values requires the implication of fast current controllers. In this paper, model predictive deadbeat controllers are proposed to control the stator currents of five-phase BLDC machines under normal and faulty conditions. Open circuit fault is considered for both one and two stator phases, and the behaviour of proposed controlling method is evaluated. This evaluation is generally focused on first, sensitivity of proposed controlling method and second, its speed in following reference current values under transient states. Proposed method is simulated and is verified experimentally on a five-phase BLDC drive

  9. Design, construction, and electrical test results of dual phase controlled multi-megawatt oscillators for ''oscillating field current drive'' on ZT40M

    International Nuclear Information System (INIS)

    Reass, W.A.; Gribble, R.F.; Hammer, C.F.

    1985-01-01

    This paper provides the design and construction details and the electrical test results of 1 kHz, 10 MW and 20 MW phase controlled class D or E driven oscillators. To test the concept of oscillating field current drive, the 10 MW oscillator is directly coupled to the toroidal field (TF) circuits; the 20 MW oscillator to the poloidal field (PF) circuits. By maintaining the proper phase angle between PF and TF oscillators, theory shows that for reversed field pinch plasmas, discharges can be sustained without expenditure of mean magnetizing (or drive) flux. Each oscillator consists of an L-C tank circuit driven by 20 parallel ML8618 magnetically beamed triodes. Each circuit can provide up to 45 MVAR of tank circulating power when driven at its maximum rating. For the 10 MW and 20 MW load power requirements, 450 kJ, 22 kV B + capacitor banks will provide for over a 10 mS oscillating envelope. To control phase and amplitude, the grid drive waveform timing and conduction angle of the output tubes are changed. Each driver circuit consists of a fiber optic controlled hot deck with 2 ML8618s in a cathode follower configuration

  10. Measurement of critical current density of YBCO film by a mutual inductive method using a drive coil with a sharp iron core

    International Nuclear Information System (INIS)

    Yamada, H.; Bitoh, A.; Mitsuno, Y.; Imai, I.; Nomura, K.; Kanayama, K.; Nakagawa, S.; Mawatari, Y.; Yamasaki, H.

    2005-01-01

    Recent developments in high-temperature superconductors have facilitated the production of high critical current and large-area films by the PLD method or MOD method. Nondestructive measurement techniques for high quality films are of great importance to estimate superconducting properties, such as the critical current density, J C . The inductive method using the third-harmonic voltage component, V 3 , is a promising technique for the measurement of the properties of J C . On inductive determination of J C for high-J C thin films and thicker films (thickness d ≥ 0.1 mm), the drive coil must generate a magnetic field sufficiently large to break the complete field shielding of the film. Therefore, we investigated a mutual inductance technique using a drive coil with a sharp ferromagnetic core for investigation of the J C of the PLD-YBCO film. As a result, an abrupt nonlinear increase in the voltage across the pick-up coil was detected after magnetic full penetration of the film, and the threshold of the drive current I th was suppressed to 0.23-0.28 times as compared with that measured by the inductive method using the third-harmonic voltage, V 3 . FEM analysis indicated the diameter of the excitation field region to be 0.6 mm in the case of a 0.4 mm φ iron core. The E-J characters measured by the mutual inductive method as a function of frequency agreed well with those measured by the inductive method using V 3

  11. On the NBI system for substantial current drive in a fusion power plant: Status and R and D needs for ion source and laser neutralizer

    Energy Technology Data Exchange (ETDEWEB)

    Franzen, P., E-mail: peter.franzen@ipp.mpg.de; Fantz, U.

    2014-11-15

    Highlights: • NBI is a candidate for a cw tokamak DEMO due to its high current drive efficiency. • The plug-in efficiency must be improved from the present 20–30% to more than 50%. • A suitable candidate is a photo neutralizer with almost 100% neutralization efficiency; basic feasibility studies are underway. • Cw operation with a large availability puts rather high demands on source operation with some safety margins, especially for the components with high power density loads (source back plate and extraction system). • Alternatives to the present use of cesium are under exploitations. - Abstract: The requirements for the heating and current drive systems of a fusion power plant will strongly depend on the DEMO scenario. The paper discusses the R and D needs for a neutral beam injection system — being a candidate due to the highest current drive efficiency — for the most demanding scenario, a steady state tokamak DEMO. Most important issues are the improvement of the wall-plug efficiency from the present ∼25% to the required 50–60% by improving the neutralization efficiency with a laser neutralizer system and the improvement of the reliability of the ion source operation. The demands on and the potential of decreasing the ion source operation pressure, as well as decreasing the amount of co-extracted electrons and backstreaming ions are discussed using the ITER requirements and solutions as basis. A further concern is the necessity of cesium for which either the cesium management must be improved or alternatives to cesium for the production of negative ions have to be identified.

  12. Comparison of Current Control Methods on Carrier Based VSI-PWM Inverter Drives From Line Power Quality Aspect

    Directory of Open Access Journals (Sweden)

    Muh. Imran Hamid

    2008-08-01

    Full Text Available This paper describes simulation result of two methods in current controlling for carrier based VSI-PWM inverter: hysteresis and ramp comparison control. The simulation is useful in selection of ASDs and generally–converter, from power quality point of view. Simulation results show that both ramp comparison and hysteresis control methods gives difference characteristic on line voltage and line current. A ramp comparison method is better in form of lower effect on line current distortion compare with hysteresis control method. Meanwhile, for line voltage distortion, hysteresis control seen better.

  13. Firing-rate response of linear and nonlinear integrate-and-fire neurons to modulated current-based and conductance-based synaptic drive.

    Science.gov (United States)

    Richardson, Magnus J E

    2007-08-01

    Integrate-and-fire models are mainstays of the study of single-neuron response properties and emergent states of recurrent networks of spiking neurons. They also provide an analytical base for perturbative approaches that treat important biological details, such as synaptic filtering, synaptic conductance increase, and voltage-activated currents. Steady-state firing rates of both linear and nonlinear integrate-and-fire models, receiving fluctuating synaptic drive, can be calculated from the time-independent Fokker-Planck equation. The dynamic firing-rate response is less easy to extract, even at the first-order level of a weak modulation of the model parameters, but is an important determinant of neuronal response and network stability. For the linear integrate-and-fire model the response to modulations of current-based synaptic drive can be written in terms of hypergeometric functions. For the nonlinear exponential and quadratic models no such analytical forms for the response are available. Here it is demonstrated that a rather simple numerical method can be used to obtain the steady-state and dynamic response for both linear and nonlinear models to parameter modulation in the presence of current-based or conductance-based synaptic fluctuations. To complement the full numerical solution, generalized analytical forms for the high-frequency response are provided. A special case is also identified--time-constant modulation--for which the response to an arbitrarily strong modulation can be calculated exactly.

  14. Current status on advanced aqueous reprocessing process (next) in FaCT project

    International Nuclear Information System (INIS)

    Washiya, Tadahiro; Myochin, Munetaka; Koyama, Tomozo

    2009-01-01

    Japan Atomic Energy Agency (JAEA) launched the Fast Reactor Cycle Technology Development (FaCT) project in cooperation with the Japanese electric utilities in 2006. An integration of the advanced aqueous reprocessing concept and the simplified pelletizing fuel fabrication was selected as the most promising fuel cycle system. In order to accomplish the integration, R and D tasks were launched as FaCT Project in 2006 by Japanese joint team. The New Extraction System for TRU Recovery (NEXT) system is an advanced aqueous reprocessing concept which was based on the well established aqueous reprocessing for LWR spent fuel and newly applied processes such as uranium crystallization and extraction chromatography for MAs recovery. Main task of the NEXT process is to develop the TRU recovery process and equipments with high reliability, criticality safety, high durability and remote maintainability. In the FaCT project, all innovative technologies are planned to be developed within the next decade focusing on the future commercialization of FBR cycle systems. The judgment of the adoption of each innovative technology will be made by 2010 based on the results of R and Ds. The development of each technology is to be completed by around 2015. By the same time, it is scheduled to present the conceptual design of commercial and demonstrative fast reactor cycle facilities. The six items (Disassembling and shearing, Fuel dissolution, Uranium Crystallization, Single cycle co-extraction of U, Pu and Np, MA recovery by extraction chromatography and Waste treatment) have been identified as the issues to be developed corresponding to each process step. Current R and D status and prospects of this system until around 2015 is reported. (author)

  15. An advanced current control compensation scheme to improve the microgrid power quality without using dedicated compensation devices

    DEFF Research Database (Denmark)

    Naderipour, A.; Zin, A. A.Mohd; Habibuddin, M. H.

    2016-01-01

    of the harmonics in Microgrid (MG) and between MG and Power Common Coupling (PCC). The current harmonics in the grid and MG are compensated without using dedicated compensation devices, such as active power filters (APFs), by the proposed current controller which is contain an advanced synchronous reference frame...

  16. Advanced thermal-hydraulic and neutronic codes: current and future applications. Summary and conclusions

    International Nuclear Information System (INIS)

    2001-05-01

    An OECD Workshop on Advanced Thermal-Hydraulic and Neutronic Codes Applications was held from 10 to 13 April 2000, in Barcelona, Spain, sponsored by the Committee on the Safety of Nuclear Installations (CSNI) of the OECD Nuclear Energy Agency (NEA). It was organised in collaboration with the Spanish Nuclear Safety Council (CSN) and hosted by CSN and the Polytechnic University of Catalonia (UPC) in collaboration with the Spanish Electricity Association (UNESA). The objectives of the Workshop were to review the developments since the previous CSNI Workshop held in Annapolis [NEA/CSNI/ R(97)4; NUREG/CP-0159], to analyse the present status of maturity and remnant needs of thermal-hydraulic (TH) and neutronic system codes and methods, and finally to evaluate the role of these tools in the evolving regulatory environment. The Technical Sessions and Discussion Sessions covered the following topics: - Regulatory requirements for Best-Estimate (BE) code assessment; - Application of TH and neutronic codes for current safety issues; - Uncertainty analysis; - Needs for integral plant transient and accident analysis; - Simulators and fast running codes; - Advances in next generation TH and neutronic codes; - Future trends in physical modeling; - Long term plans for development of advanced codes. The focus of the Workshop was on system codes. An incursion was made, however, in the new field of applying Computational Fluid Dynamic (CFD) codes to nuclear safety analysis. As a general conclusion, the Barcelona Workshop can be considered representative of the progress towards the targets marked at Annapolis almost four years ago. The Annapolis Workshop had identified areas where further development and specific improvements were needed, among them: multi-field models, transport of interfacial area, 2D and 3D thermal-hydraulics, 3-D neutronics consistent with level of details of thermal-hydraulics. Recommendations issued at Annapolis included: developing small pilot/test codes for

  17. Proceedings of the workshop on advanced thermal-hydraulic and neutronic codes: current and future applications

    International Nuclear Information System (INIS)

    2001-01-01

    An OECD Workshop on Advanced Thermal-Hydraulic and Neutronic Codes Applications was held from 10 to 13 April 2000, in Barcelona, Spain, sponsored by the Committee on the Safety of Nuclear Installations (CSNI) of the OECD Nuclear Energy Agency (NEA). It was organised in collaboration with the Spanish Nuclear Safety Council (CSN) and hosted by CSN and the Polytechnic University of Catalonia (UPC) in collaboration with the Spanish Electricity Association (UNESA). The objectives of the Workshop were to review the developments since the previous CSNI Workshop held in Annapolis [NEA/CSNI/ R(97)4; NUREG/CP-0159], to analyse the present status of maturity and remnant needs of thermal-hydraulic (TH) and neutronic system codes and methods, and finally to evaluate the role of these tools in the evolving regulatory environment. The Technical Sessions and Discussion Sessions covered the following topics: - Regulatory requirements for Best-Estimate (BE) code assessment; - Application of TH and neutronic codes for current safety issues; - Uncertainty analysis; - Needs for integral plant transient and accident analysis; - Simulators and fast running codes; - Advances in next generation TH and neutronic codes; - Future trends in physical modeling; - Long term plans for development of advanced codes. The focus of the Workshop was on system codes. An incursion was made, however, in the new field of applying Computational Fluid Dynamic (CFD) codes to nuclear safety analysis. As a general conclusion, the Barcelona Workshop can be considered representative of the progress towards the targets marked at Annapolis almost four years ago. The Annapolis Workshop had identified areas where further development and specific improvements were needed, among them: multi-field models, transport of interfacial area, 2D and 3D thermal-hydraulics, 3-D neutronics consistent with level of details of thermal-hydraulics. Recommendations issued at Annapolis included: developing small pilot/test codes for

  18. Malignant gliomas: current perspectives in diagnosis, treatment, and early response assessment using advanced quantitative imaging methods

    Directory of Open Access Journals (Sweden)

    Ahmed R

    2014-03-01

    Full Text Available Rafay Ahmed,1 Matthew J Oborski,2 Misun Hwang,1 Frank S Lieberman,3 James M Mountz11Department of Radiology, 2Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA, USA; 3Department of Neurology and Department of Medicine, Division of Hematology/Oncology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USAAbstract: Malignant gliomas consist of glioblastomas, anaplastic astrocytomas, anaplastic oligodendrogliomas and anaplastic oligoastrocytomas, and some less common tumors such as anaplastic ependymomas and anaplastic gangliogliomas. Malignant gliomas have high morbidity and mortality. Even with optimal treatment, median survival is only 12–15 months for glioblastomas and 2–5 years for anaplastic gliomas. However, recent advances in imaging and quantitative analysis of image data have led to earlier diagnosis of tumors and tumor response to therapy, providing oncologists with a greater time window for therapy management. In addition, improved understanding of tumor biology, genetics, and resistance mechanisms has enhanced surgical techniques, chemotherapy methods, and radiotherapy administration. After proper diagnosis and institution of appropriate therapy, there is now a vital need for quantitative methods that can sensitively detect malignant glioma response to therapy at early follow-up times, when changes in management of nonresponders can have its greatest effect. Currently, response is largely evaluated by measuring magnetic resonance contrast and size change, but this approach does not take into account the key biologic steps that precede tumor size reduction. Molecular imaging is ideally suited to measuring early response by quantifying cellular metabolism, proliferation, and apoptosis, activities altered early in treatment. We expect that successful integration of quantitative imaging biomarker assessment into the early phase of clinical trials could provide a novel approach for testing new therapies

  19. Advanced simulation capability for environmental management - current status and future applications

    International Nuclear Information System (INIS)

    Freshley, Mark; Scheibe, Timothy; Robinson, Bruce; Moulton, J. David; Dixon, Paul; Marble, Justin; Gerdes, Kurt; Stockton, Tom; Seitz, Roger; Black, Paul

    2013-01-01

    The U.S. Department of Energy (US DOE) Office of Environmental Management (EM), Office of Soil and Groundwater (EM-12), is supporting development of the Advanced Simulation Capability for Environmental Management (ASCEM). ASCEM is a state-of-the-art scientific tool and approach that is currently aimed at understanding and predicting contaminant fate and transport in natural and engineered systems. ASCEM is a modular and open source high-performance computing tool. It will be used to facilitate integrated approaches to modeling and site characterization, and provide robust and standardized assessments of performance and risk for EM cleanup and closure activities. The ASCEM project continues to make significant progress in development of capabilities, with current emphasis on integration of capabilities in FY12. Capability development is occurring for both the Platform and Integrated Tool-sets and High-Performance Computing (HPC) multi-process simulator. The Platform capabilities provide the user interface and tools for end-to-end model development, starting with definition of the conceptual model, management of data for model input, model calibration and uncertainty analysis, and processing of model output, including visualization. The HPC capabilities target increased functionality of process model representations, tool-sets for interaction with Platform, and verification and model confidence testing. The integration of the Platform and HPC capabilities were tested and evaluated for EM applications in a set of demonstrations as part of Site Applications Thrust Area activities in 2012. The current maturity of the ASCEM computational and analysis capabilities has afforded the opportunity for collaborative efforts to develop decision analysis tools to support and optimize radioactive waste disposal. Recent advances in computerized decision analysis frameworks provide the perfect opportunity to bring this capability into ASCEM. This will allow radioactive waste

  20. High Current ESD Test of Advanced Triple Junction Solar Array Coupon

    Science.gov (United States)

    Wright, Kenneth H., Jr.; Schneider, Todd A.; Vaughn, Jason A.; Hoang, Bao; Wong, Frankie

    2015-01-01

    A test was conducted on an Advanced Triple Junction (ATJ) coupon that was part of a risk reduction effort in the development of a high-powered solar array design by SSL. The ATJ coupon was a small, 4-cell, two-string configuration that has served as the basic test coupon design used in previous SSL environmental aging campaigns. The coupon has many attributes of the flight design; e.g., substrate structure with graphite face sheets, integrated by-pass diodes, cell interconnects, RTV grout, wire routing, etc. The objective of the present test was to evaluate the performance of the coupon after being subjected to induced electrostatic discharge testing at two string voltages (100 V, 150 V) and four array current (1.65 A, 2.0 A, 2.475 A, and 3.3 A). An ESD test circuit, unique to SSL solar array design, was built that simulates the effect of missing cells and strings in a full solar panel with special primary arc flashover circuitry. A total of 73 primary arcs were obtained that included 7 temporary sustained arcs (TSA) events. The durations of the TSAs ranged from 50 micros to 2.9 ms. All TSAs occurred at a string voltage of 150 V. Post-test Large Area Pulsed Solar Simulator (LAPSS), Dark I-V, and By-Pass Diode tests showed that no degradation occurred due to the TSA events. In addition, the post-test insulation resistance measured was > 50 G-ohms between cells and substrate. These test results indicate a robust design for application to a high-current, high-power mission application.

  1. Spermatogonial stem cells: Current biotechnological advances in reproduction and regenerative medicine.

    Science.gov (United States)

    Aponte, Pedro Manuel

    2015-05-26

    Spermatogonial stem cells (SSCs) are the germ stem cells of the seminiferous epithelium in the testis. Through the process of spermatogenesis, they produce sperm while concomitantly keeping their cellular pool constant through self-renewal. SSC biology offers important applications for animal reproduction and overcoming human disease through regenerative therapies. To this end, several techniques involving SSCs have been developed and will be covered in this article. SSCs convey genetic information to the next generation, a property that can be exploited for gene targeting. Additionally, SSCs can be induced to become embryonic stem cell-like pluripotent cells in vitro. Updates on SSC transplantation techniques with related applications, such as fertility restoration and preservation of endangered species, are also covered on this article. SSC suspensions can be transplanted to the testis of an animal and this has given the basis for SSC functional assays. This procedure has proven technically demanding in large animals and men. In parallel, testis tissue xenografting, another transplantation technique, was developed and resulted in sperm production in testis explants grafted into ectopical locations in foreign species. Since SSC culture holds a pivotal role in SSC biotechnologies, current advances are overviewed. Finally, spermatogenesis in vitro, already demonstrated in mice, offers great promises to cope with reproductive issues in the farm animal industry and human clinical applications.

  2. Clinical Applications of Contrast-Enhanced Perfusion MRI Techniques in Gliomas: Recent Advances and Current Challenges

    Directory of Open Access Journals (Sweden)

    Junfeng Zhang

    2017-01-01

    Full Text Available Gliomas possess complex and heterogeneous vasculatures with abnormal hemodynamics. Despite considerable advances in diagnostic and therapeutic techniques for improving tumor management and patient care in recent years, the prognosis of malignant gliomas remains dismal. Perfusion-weighted magnetic resonance imaging techniques that could noninvasively provide superior information on vascular functionality have attracted much attention for evaluating brain tumors. However, nonconsensus imaging protocols and postprocessing analysis among different institutions impede their integration into standard-of-care imaging in clinic. And there have been very few studies providing a comprehensive evidence-based and systematic summary. This review first outlines the status of glioma theranostics and tumor-associated vascular pathology and then presents an overview of the principles of dynamic contrast-enhanced MRI (DCE-MRI and dynamic susceptibility contrast-MRI (DSC-MRI, with emphasis on their recent clinical applications in gliomas including tumor grading, identification of molecular characteristics, differentiation of glioma from other brain tumors, treatment response assessment, and predicting prognosis. Current challenges and future perspectives are also highlighted.

  3. Modeling interfacial glass-water reactions: recent advances and current limitations

    International Nuclear Information System (INIS)

    Pierce, Eric M.; Frugier, Pierre; Criscenti, Louise J.; Kwon, Kideok D.; Kerisit, Sebastien N.

    2014-01-01

    Describing the reactions that occur at the glass-water interface and control the development of the altered layer constitutes one of the main scientific challenges impeding existing models from providing accurate radionuclide release estimates. Radionuclide release estimates are a critical component of the safety basis for geologic repositories. The altered layer (i.e., amorphous hydrated surface layer and crystalline reaction products) represents a complex region, both physically and chemically, sandwiched between two distinct boundaries-pristine glass surface at the inner most interface and aqueous solution at the outer most interface. Computational models, spanning different length and timescales, are currently being developed to improve our understanding of this complex and dynamic process with the goal of accurately describing the mesoscale changes that occur as the system evolves. These modeling approaches include geochemical simulations (i.e., classical reaction path simulations and glass reactivity in allowance for alteration layer simulations), Monte Carlo simulations, and molecular dynamics methods. Discussed in this manuscript are the advances and limitations of each modeling approach placed in the context of the glass-water reaction and how collectively these approaches provide insights into the mechanisms that control the formation and evolution of altered layers. New results are presented as examples of each approach. (authors)

  4. Study of the dynamics of the lower hybrid wave during current drive in tokamaks and of the Weyl-Wigner in quantum mechanics

    International Nuclear Information System (INIS)

    Bizarro, J.P.

    1993-10-01

    A comprehensive and detailed investigation is presented on the dynamics of the lower hybrid wave during current drive in tokamaks in situations where toroidally induced ray stochasticity is important and on the Weyl-Wigner formalism for rotation angle and angular momentum variables in quantum mechanics. It is shown that ray-tracing and Fokker-Planck codes are reliable tools for modelling the physics of lower-hybrid current drive provided a large number of rays is used when stochastic effects are important, and, in particular, that such codes are capable of reproducing the experimentally observed features of the hard X-ray emission. The balance between the wave damping and the stochastic divergence of nearby ray trajectories appears to be of great importance in governing the dynamics of the launched power spectrum and in establishing the characteristics of the deposition patterns. The implications of rotational periodicity and of angular momentum quantization for the Weyl-Wigner formalism are analyzed. Particular attention is paid to discreteness and its consequences: importance of evenness and oddness, use of two difference operators instead of one differential operator. 24 refs

  5. Current-drive and plasma formation experiments on the Versator-II tokamak using lower-hybrid and electron-cyclotron waves

    International Nuclear Information System (INIS)

    Colborn, J.A.

    1992-01-01

    During lower-hybrid current-driven (LHCD) tokamak discharges with thermal electron temperature T e ∼ 150 eV, a two-parallel-temperature tail is observed in the electron distribution function. The cold tail extends to parallel energy E parallel ∼ 4.5 keV with temperature T cold tail ∼ 1.5 keV, and the hot tail extends to E parallel > 150 keV with T hot tail > 40 keV. Fokker-Planck computer simulations suggest the cold tail is created by low power, high-N parallel sidelobes in the lower-hybrid antenna spectrum, and that these sidelobes bridge the spectral gap, enabling current drive on small tokamaks such as Versator. During plasma-formation experiments using 28 GHz electroncyclotron (EC) waves, the plasma is born near the EC layer, then moves toward the upper-hybrid (UH) layer within 100-200μs. Wave power is detected in the plasma with frequency f = 300 MHz. Measured turbulent plasma fluctuations are correlated with decay-wave amplitude. Electron-cyclotron current-drive (ECCD) is observed with loop voltage V loop ≤ 0 and fully sustained plasma current I p approx-lt 15 kA at densities up to [n e ] = 2 x 10 12 cm -3 . The efficiency falls rapidly to zero as the density is raised, suggesting the ECCD depends on low collisonality. The EC waves enhance magnetic turbulence in the frequency range 50 kHz approx-lt f approx-lt 400 kHz by up to an order of magnitude. The time-of-arrival of the turbulence to probes at the plasma boundary is longer when the EC layer is farther from the probes

  6. Development of ball bearing in high temperature water for in-vessel type control rod drive mechanism of advanced marine reactor

    International Nuclear Information System (INIS)

    Nunokawa, Hiroshi; Yoritsune, Tsutomu; Imayoshi, Shou; Ochiai, Masa-aki; Ishida, Toshihisa

    2001-06-01

    An advanced marine reactor MRX designed by Japan Atomic Energy Research Institute (JAERI) adopts an in-vessel type control rod drive mechanism, which is installed inside the reactor vessel. Since the in-vessel type control rod drive mechanism should work at a severe condition of a high temperature and high pressure water - 310degC and 12 MPa -, the JAERI has developed the components, a ball bearing of which especially is one of key technologies for realization of this type mechanism. The present report describes the development of the ball bearing containing a survey of materials, material screening tests on oxidation in an autoclave and rolling wear by a small facility, a trial fabrication of the full size ball bearing, and endurance test of it in the high temperature water. As a result, it was found from the development that the materials of cobalt alloy for both of the inner and outer races, cermet for the ball, and graphite for the retainer can satisfy the design condition of the ball bearing. (author)

  7. Integrated Application of Active Controls (IAAC) technology to an advanced subsonic transport project: Current and advanced act control system definition study

    Science.gov (United States)

    1982-01-01

    The Current and Advanced Technology ACT control system definition tasks of the Integrated Application of Active Controls (IAAC) Technology project within the Energy Efficient Transport Program are summarized. The systems mechanize six active control functions: (1) pitch augmented stability; (2) angle of attack limiting; (3) lateral/directional augmented stability; (4) gust load alleviation; (5) maneuver load control; and (6) flutter mode control. The redundant digital control systems meet all function requirements with required reliability and declining weight and cost as advanced technology is introduced.

  8. Numerical Simulations of Electrokinetic Processes Comparing the Use of a Constant Voltage Difference or a Constant Current as Driving Force

    DEFF Research Database (Denmark)

    Paz-Garcia, Juan Manuel; Johannesson, Björn; Ottosen, Lisbeth M.

    materials and the prevention of the reinforced concrete corrosion. The electrical energy applied in an electrokinetic process produces electrochemical reactions at the electrodes. Different electrode processes can occur. When considering inert electrodes in aqueous solutions, the reduction of water...... are transported from the anode to the cathode through the closed electrical circuit of the cell. In the solution, the electrical current is carried by the ions, which move towards the electrode with different charge. Therefore, different authors have studied the system using the circuit theory. Assuming...

  9. Current advanced therapy cell-based medicinal products for type-1-diabetes treatment.

    Science.gov (United States)

    Cañibano-Hernández, Alberto; Del Burgo, Laura Sáenz; Espona-Noguera, Albert; Ciriza, Jesús; Pedraz, Jose Luis

    2018-03-27

    In the XXI century diabetes mellitus has become one of the main threats to human health with higher incidence in regions such as Europe and North America. Type 1 diabetes mellitus (T1DM) occurs as a consequence of the immune-mediated destruction of insulin producing β-cells located in the endocrine part of the pancreas, the islets of Langerhans. The administration of exogenous insulin through daily injections is the most prominent treatment for T1DM but its administration is frequently associated to failure in glucose metabolism control, finally leading to hyperglycemia episodes. Other approaches have been developed in the past decades, such as whole pancreas and islet allotransplantation, but they are restricted to patients who exhibit frequent episodes of hypoglycemia or renal failure because the lack of donors and islet survival. Moreover, patients transplanted with either whole pancreas or islets require of immune suppression to avoid the rejection of the transplant. Currently, advanced therapy medicinal products (ATMP), such as implantable devices, have been developed in order to reduce immune rejection response while increasing cell survival. To overcome these issues, ATMPs must promote vascularization, guaranteeing the nutritional contribution, while providing O 2 until vasculature can surround the device. Moreover, it should help in the immune-protection to avoid acute and chronic rejection. The transplanted cells or islets should be embedded within biomaterials with tunable properties like injectability, stiffness and porosity mimicking natural ECM structural characteristics. And finally, an infinitive cell source that solves the donor scarcity should be found such as insulin producing cells derived from mesenchymal stem cells (MSCs), embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs). Several companies have registered their ATMPs and future studies envision new prototypes. In this review, we will discuss the mechanisms and etiology of

  10. Coevolution of patients and hospitals: how changing epidemiology and technological advances create challenges and drive organizational innovation.

    Science.gov (United States)

    Lega, Federico; Calciolari, Stefano

    2012-01-01

    Over the last 20 years, hospitals have revised their organizational structures in response to new environmental pressures. Today, demographic and epidemiologic trends and recent technological advances call for new strategies to cope with ultra-elderly frail patients characterized by chronic conditions, high-severity health problems, and complex social situations. The main areas of change surround new ways of managing emerging clusters of patients whose needs are not efficiently or effectively met within traditional hospital organizations. Following the practitioner and academic literature, we first identify the most relevant clusters of new kinds of patients who represent an increasingly larger share of the hospital population in developed countries. Second, we propose a framework that synthesizes the major organizational innovations adopted by successful organizations around the world. We conclude by substantiating the trends of and the reasoning behind the prospective pattern of hospital organizational development.

  11. Dementia & Driving

    Science.gov (United States)

    ... find the loss of driving privileges and the inherent loss of independence upsetting. Encourage the individual with ... to modify their driving. This can reduce the risk of an accident if the individual’s driving skills ...

  12. Drive Stands

    Data.gov (United States)

    Federal Laboratory Consortium — The Electrical Systems Laboratory (ESL)houses numerous electrically driven drive stands. A drive stand consists of an electric motor driving a gearbox and a mounting...

  13. The Receptor for Advanced Glycation Endproducts (RAGE) drives T cell survival and inflammation in Type 1 diabetes mellitus

    Science.gov (United States)

    Durning, Sean P.; Preston-Hurlburt, Paula; Clark, Paul R.; Xu, Ding; Herold, Kevan C.

    2016-01-01

    The ways in which environmental factors participate in the progression of autoimmune diseases are not known. After initiation, it takes years before patients at risk for type 1 diabetes (T1D) develop hyperglycemia. The receptor for advanced glycated endproducts (RAGE) is a scavenger receptor of the immunoglobulin family that binds damage associated molecular patterns (DAMPs) and advanced glycated endproducts (AGEs) and can trigger cell activation. We previously found constitutive intracellular RAGE expression in lymphocytes from patients with T1D. Herein, we show that there is increased RAGE expression in T cells from at-risk euglycemic relatives who progress to T1D compared to healthy control subjects, and in the CD8+ T cells in the at-risk relatives who do vs those who do not progress to T1D. Detectable levels of the RAGE ligand HMGB1 were present in serum from at-risk subjects and patients with T1D. Transcriptome analysis of RAGE+ vs RAGE- T cells from patients with T1D showed differences in signaling pathways associated with increased cell activation and survival‥ Additional markers for effector memory cells and inflammatory function were elevated in the RAGE+ CD8+ cells of T1D patients and at-risk relatives of patients prior to disease onset. These studies suggest that expression of RAGE in T cells of subjects progressing to disease predates dysglycemia. These findings imply that RAGE expression enhances the inflammatory function of T cells and its increased levels observed in T1D patients may account for the chronic autoimmune response when DAMPs are released following cell injury and killing. PMID:27655844

  14. Development of long-pulse heating & current drive actuators & operational techniques compatible with a high-Z divertor & first wall

    Energy Technology Data Exchange (ETDEWEB)

    Tynan, George [Univ. of California, San Diego, CA (United States)

    2018-01-09

    This was a collaboration between UCSD and MIT to study the effective application of ion-cyclotron heating (ICRH) on the EAST tokamak, located in China. The original goal was for UCSD to develop a diagnostic that would allow measurement of the steady state, or DC, convection pattern that develops on magnetic field lines that attach or connect to the ICRH antenna. This diagnostic would then be used to develop techniques and approaches that minimize or even eliminate such DC convection during application of strong ICRH heating. This was thought to then indicate reduction or elimination of parasitic losses of heating power, and thus be an indicator of effective RF heating. The original plan to use high speed digital gas-puff imaging (GPI) of the antenna-edge plasma region in EAST was ultimately unsuccessful due to limitations in machine and camera operations. We then decided to attempt the same experiment on the ALCATOR C-MOD tokamak at MIT which had a similar instrument already installed. This effort was ultimately successful, and demonstrated that the underlying idea of using GPI as a diagnostic for ICRH antenna physics would, in fact, work. The two-dimensional velocity fields of the turbulent structures, which are advected by RF-induced E x B flows, are obtained via the time-delay estimation (TDE) techniques. Both the magnitude and radial extension of the radial electric field E-r were observed to increase with the toroidal magnetic field strength B and the ICRF power. The TDE estimations of RF-induced plasma potentials are consistent with previous results based on the probe measurements of poloidal phase velocity. The results suggest that effective ICRH heating with reduced impurity production is possible when the antenna/box system is designed so as to reduce the RF-induced image currents that flow in the grounded conducting antenna frame elements that surround the RF antenna current straps.

  15. Identifying Method of Drunk Driving Based on Driving Behavior

    Directory of Open Access Journals (Sweden)

    Xiaohua Zhao

    2011-05-01

    Full Text Available Drunk driving is one of the leading causes contributing to traffic crashes. There are numerous issues that need to be resolved with the current method of identifying drunk driving. Driving behavior, with the characteristic of real-time, was extensively researched to identify impaired driving behaviors. In this paper, the drives with BACs above 0.05% were defined as drunk driving state. A detailed comparison was made between normal driving and drunk driving. The experiment in driving simulator was designed to collect the driving performance data of the groups. According to the characteristics analysis for the effect of alcohol on driving performance, seven significant indicators were extracted and the drunk driving was identified by the Fisher Discriminant Method. The discriminant function demonstrated a high accuracy of classification. The optimal critical score to differentiate normal from drinking state was found to be 0. The evaluation result verifies the accuracy of classification method.

  16. Integrated Application of Active Controls (IAAC) technology to an advanced subsonic transport project: Current and advanced act control system definition study. Volume 2: Appendices

    Science.gov (United States)

    Hanks, G. W.; Shomber, H. A.; Dethman, H. A.; Gratzer, L. B.; Maeshiro, A.; Gangsaas, D.; Blight, J. D.; Buchan, S. M.; Crumb, C. B.; Dorwart, R. J.

    1981-01-01

    The current status of the Active Controls Technology (ACT) for the advanced subsonic transport project is investigated through analysis of the systems technical data. Control systems technologies under examination include computerized reliability analysis, pitch axis fly by wire actuator, flaperon actuation system design trade study, control law synthesis and analysis, flutter mode control and gust load alleviation analysis, and implementation of alternative ACT systems. Extensive analysis of the computer techniques involved in each system is included.

  17. Drive Cost Reduction, Increase Innovation and Mitigate Risk with Advanced Knowledge Discovery Tools Designed to Unlock and Leverage Prior Knowledge

    International Nuclear Information System (INIS)

    Mitchell, I.

    2016-01-01

    Full text: The nuclear industry is knowledge-intensive and includes a diverse number of stakeholders. Much of this knowledge is at risk as engineers, technicians and project professionals retire, leaving a widening skills and information gap. This knowledge is critical in an increasingly complex environment with information from past projects often buried in decades-old, non-integrated systems enterprise. Engineers can spend 40% or more of their time searching for answers across the enterprise instead of solving problems. The inability to access trusted industry knowledge results in increased risk and expense. Advanced knowledge discovery technologies slash research times by as much as 75% and accelerate innovation and problem solving by giving technical professionals access to the information they need, in the context of the problems they are trying to solve. Unlike traditional knowledge management approaches, knowledge discovery tools powered by semantic search technologies are adept at uncovering answers in unstructured data and require no tagging, organization or moving of data, meaning a smaller IT footprint and faster time-to-knowledge. This session will highlight best-in-class knowledge discovery technologies, content, and strategies to give nuclear industry organizations the ability to leverage the corpus of enterprise knowledge into the future. (author

  18. Current trends and recent advances in diagnosis, therapy, and prevention of hepatocellular carcinoma.

    Science.gov (United States)

    Wang, Chun-Hsiang; Wey, Keh-Cherng; Mo, Lein-Ray; Chang, Kuo-Kwan; Lin, Ruey-Chang; Kuo, Jen-Juan

    2015-01-01

    Hepatocellular carcinoma (HCC) has been one of the most fatal malignant tumors worldwide and its associated morbidity and mortality remain of significant concern. Based on in-depth reviews of serological diagnosis of HCC, in addition to AFP, there are other biomarkers: Lens culinaris agglutinin-reactive AFP (AFP-L3), des- carboxyprothrombin (DCP), tyrosine kinase with Ig and eprdermal growth factor (EGF) homology domains 2 (TIE2)-espressing monocytes (TEMs), glypican-3 (GPC3), Golgi protein 73 (GP73), interleukin-6 (IL-6), and squamous cell carcinoma antigen (SCCA) have been proposed as biomarkers for the early detection of HCC. The diagnosis of HCC is primarily based on noninvasive standard imaging methods, such as ultrasound (US), dynamic multiphasic multidetector-row CT (MDCT) and magnetic resonance imaging (MRI). Some experts advocate gadolinium diethyl-enetriamine pentaacetic acid (Gd-EOB-DTPA) MRI and contrast-enhanced US as the promising imaging madalities of choice. With regard to recent advancements in tissue markers, many cuting-edge technologies using genome-wide DNA microarrays, qRT-PCR, and proteomic and inmunostaining studies have been implemented in an attempt to identify markers for early diagnosis of HCC. Only less than half of HCC patients at initial diagnosis are at an early stage treatable with curative options: local ablation, surgical resection, or liver transplant. Transarterial chemoembolization (TACE) is considered the standard of care with palliation for intermediate stage HCC. Recent innovative procedures using drug-eluting-beads and radioembolization using Yttrium-90 may exhibit beneficial effects in HCC treatment. During the past few years, several molecular targeted agents have been evaluated in clinical trials in advanced HCC. Sorafenib is currently the only approved systemic treatment for HCC. It has been approved for the therapy of asymptomatic HCC patients with well-preserved liver function who are not candidates for potentially

  19. Generation of runaway electrons during deterioration of lower hybrid power coupling in lower hybrid current drive plasmas in the HT-7 tokamak

    International Nuclear Information System (INIS)

    Chen, Z Y; Ju, H J; Zhu, J X; Li, M; Cai, W D; Liang, H F; Wan, B N; Shi, Y J; Xu, H D

    2009-01-01

    Efficient coupling of lower hybrid (LH) power from the wave launcher to the plasma is a very important issue in lower hybrid current drive (LHCD) experiments. The large unbalanced reflections in the grill trigger the LH protection system, which will trip the power, resulting in the reduction of the coupled LH power. The generation of runaway electrons has been investigated in LHCD plasmas with deterioration of LH coupling in the HT-7 tokamak. The deterioration of LH coupling results in an increase of the loop voltage and a more energetic fast electron population. These two effects favor the generation of a runaway population. It is found that most of the fast electrons generated by LH waves through parallel electron Landau damping were converted into a runaway population through the acceleration from the toroidal electric field when significant deterioration of LH coupling occurs.

  20. Current and future studies of actinides materials at the advanced light source

    International Nuclear Information System (INIS)

    Shuh, D.K.

    2002-01-01

    The vacuum ultraviolet (VUV)/soft X-ray region of the synchrotron radiation (SR) spectrum has revolutionized the approach to surface materials chemistry/physics. This spectral region has long been recognised for its potential to afford investigations of fundamental actinide science and to provide an improved analytical surface characterisation capabilities for actinide materials. Previously, the actinide science community was unable to take advantage of the opportunities afforded by VUV/soft X-ray SR methodologies because of radiological safety concerns and the need to prepare pristine actinide materials compatible with experiments in ultra-high vacuum end stations. With the advent of third-generation light sources operating in the VUV/soft X-ray region, such as the Advanced Light Source (ALS) at LBNL, experiments with small amounts of actinide materials are possible. Actinide investigations at the ALS are based on a graded approach to radioactive materials safety and are conducted with the assistance of LBNL Environment, Health and Safety (EH and S) personnel during the experiments. LBNL EH and S personnel have many years of experience supporting experiments utilising radioactive materials at LBNL user-based accelerator facilities. The SR techniques and technologies used in this energy region have continued to mature, permitting more complicated investigations and enabling new spectroscopic approaches. Of particular importance for work with actinides is the development of the micro-spectroscopy and spectro-microscopy capabilities on several beamlines at the ALS. These capabilities allow the use of small amounts of actinide material. In addition, these techniques can provide information on the spatial distribution of actinide species that complements the spectral information. Early demonstrations of the ability to safely collect data from actinide micro-samples and the active support of the ALS for such experiments has led to the investigations of actinide

  1. High-power converters and AC drives

    CERN Document Server

    Wu, Bin

    2017-01-01

    This new edition reflects the recent technological advancements in the MV drive industry, such as advanced multilevel converters and drive configurations. It includes three new chapters, Control of Synchronous Motor Drives, Transformerless MV Drives, and Matrix Converter Fed Drives. In addition, there are extensively revised chapters on Multilevel Voltage Source Inverters and Voltage Source Inverter-Fed Drives. This book includes a systematic analysis on a variety of high-power multilevel converters, illustrates important concepts with simulations and experiments, introduces various megawatt drives produced by world leading drive manufacturers, and addresses practical problems and their mitigations methods.

  2. Application of Advanced Technology to Improve Plant Performance. Safety and Performance in Current NPPs

    International Nuclear Information System (INIS)

    Hashemian, H.M.

    2011-01-01

    Advances in computer technologies, signal processing, analytical modeling, and the advent of wireless sensors have provided the nuclear industry with ample means to automate and optimize maintenance activities and improve safety, efficiency, and availability, while reducing costs and radiation exposure to maintenance personnel. This paper provides a review of these developments and presents examples of their use in the nuclear power industry and the financial and safety benefits that they have produced. As the current generation of nuclear power plants have passed their mid-life, increased monitoring of their health is critical to their safe operation. This is especially true now that license renewal of nuclear power plants has accelerated, allowing some plants to operate up to 60 years or more. Furthermore, many utilities are maximizing their power output through uprating projects and retrofits. This puts additional demand and more stress on the plant equipment such as the instrumentation and control (I and C) systems and the reactor internal components making them more vulnerable to the effects of aging, degradation, and failure. In the meantime, the nuclear power industry is working to reduce generation costs by adopting condition-based maintenance strategies and automation of testing activities. These developments have stimulated great interest in on-line monitoring (OLM) technologies and new diagnostic and prognostic methods to anticipate, identify, and resolve equipment and process problems and ensure plant safety, efficiency, and immunity to accidents. The foundation for much of the required technologies has already been established through 40 years of research and development (R and D) efforts performed by numerous organizations, scientists, and engineers around the world including the author. This paper provides examples of these technologies and demonstrates how the gap between some of the more important R and D efforts and end users have been filled

  3. Current status of the active test at RRP and development programs for the advanced melter

    International Nuclear Information System (INIS)

    Kanehira, Norio

    2016-01-01

    The vitrification facility in Rokkasho Reprocessing Plant started the active tests to solidify HAW into the glass in 2007 which was the examination of the final stage before the operation, but the active test had to be discontinued due to the trouble of glass melter operation with down of pouring by deposit of noble metals on the melter bottom. After the equipment and operating conditions were improved in response to the result of the mock-up tests, a series of active tests were restarted active tests in May, 2012. These tests were finished with enough confirmation of stability in the state such as glass temperature and controlling the noble metals. JNFL has been developed the advanced melter, Joule heated ceramic melter, and the design of the advanced melter is largely different from the existing one. For the confirmation of the advanced melter performances, the full-scale inactive tests had been performed and successfully finished. This paper describes outline of development for advanced melter in Rokkasho Reprocessing Plant. (author)

  4. Faculty Development for Advancing Community Engagement in Higher Education: Current Trends and Future Directions

    Science.gov (United States)

    Welch, Marshall; Plaxton-Moore, Star

    2017-01-01

    This research involved the conduct of a conceptual review of 28 refereed journal articles and a survey of campus centers for community engagement staff to identify salient features and trends of existing faculty development programming designed to advance service-learning and community engagement in higher education. Results of this investigation…

  5. A Current Control Approach for an Abnormal Grid Supplied Ultra Sparse Z-Source Matrix Converter with a Particle Swarm Optimization Proportional-Integral Induction Motor Drive Controller

    Directory of Open Access Journals (Sweden)

    Seyed Sina Sebtahmadi

    2016-11-01

    Full Text Available A rotational d-q current control scheme based on a Particle Swarm Optimization- Proportional-Integral (PSO-PI controller, is used to drive an induction motor (IM through an Ultra Sparse Z-source Matrix Converter (USZSMC. To minimize the overall size of the system, the lowest feasible values of Z-source elements are calculated by considering the both timing and aspects of the circuit. A meta-heuristic method is integrated to the control system in order to find optimal coefficient values in a single multimodal problem. Henceforth, the effect of all coefficients in minimizing the total harmonic distortion (THD and balancing the stator current are considered simultaneously. Through changing the reference point of magnitude or frequency, the modulation index can be automatically adjusted and respond to changes without heavy computational cost. The focus of this research is on a reliable and lightweight system with low computational resources. The proposed scheme is validated through both simulation and experimental results.

  6. Emerging optical techniques in advanced cystoscopy for bladder cancer diagnosis: A review of the current literature

    NARCIS (Netherlands)

    Cauberg Evelyne, C. C.; de La Rosette, Jean J. M. C. H.; de Reijke, Theo M.

    2011-01-01

    The current standard for the diagnosis and followup of bladder cancer remains white light cystoscopy, despite its well-known limitations. The aim of this paper is to review the current literature on three optical diagnostics that have been developed to improve the performance of white light

  7. Current advances and strategies towards fully automated sample preparation for regulated LC-MS/MS bioanalysis.

    Science.gov (United States)

    Zheng, Naiyu; Jiang, Hao; Zeng, Jianing

    2014-09-01

    Robotic liquid handlers (RLHs) have been widely used in automated sample preparation for liquid chromatography-tandem mass spectrometry (LC-MS/MS) bioanalysis. Automated sample preparation for regulated bioanalysis offers significantly higher assay efficiency, better data quality and potential bioanalytical cost-savings. For RLHs that are used for regulated bioanalysis, there are additional requirements, including 21 CFR Part 11 compliance, software validation, system qualification, calibration verification and proper maintenance. This article reviews recent advances in automated sample preparation for regulated bioanalysis in the last 5 years. Specifically, it covers the following aspects: regulated bioanalysis requirements, recent advances in automation hardware and software development, sample extraction workflow simplification, strategies towards fully automated sample extraction, and best practices in automated sample preparation for regulated bioanalysis.

  8. Advances in Instrumental Analysis of Brominated Flame Retardants: Current Status and Future Perspectives

    Science.gov (United States)

    2014-01-01

    This review aims to highlight the recent advances and methodological improvements in instrumental techniques applied for the analysis of different brominated flame retardants (BFRs). The literature search strategy was based on the recent analytical reviews published on BFRs. The main selection criteria involved the successful development and application of analytical methods for determination of the target compounds in various environmental matrices. Different factors affecting chromatographic separation and mass spectrometric detection of brominated analytes were evaluated and discussed. Techniques using advanced instrumentation to achieve outstanding results in quantification of different BFRs and their metabolites/degradation products were highlighted. Finally, research gaps in the field of BFR analysis were identified and recommendations for future research were proposed. PMID:27433482

  9. Key Advances in the Systemic Therapy for Soft tissue Sarcomas: Current Status and Future Directions

    Directory of Open Access Journals (Sweden)

    Neelesh Soman

    2013-10-01

    Full Text Available Soft tissue sarcomas (STS represent a heterogeneous group of diverse neoplasms of mesenchymal origin. Once relapsed from standard therapy, STS patients have limited treatment options especially those that present with advanced or metastatic disease. In this review article, we highlight recent clinical data that led to the US Food and Drug Administration (FDA approval of pazopanib (Votrient® for STS and regorafenib (Stivarga®, BAY 73-4506 in gastrointestinal stromal tumours. We also review ongoing safety/efficacy data for trabectedin (Yondelis®, ET-743, and data from clinical studies of ridaforolimus (AP23573; MK-8669 and palifosfamide (ZIO-201. We provide a list of some promising ongoing trials in soft tissue sarcomas including first line studies of TH-302 and trabectedin. Finally, our article delves into recent advances in our understanding of the molecular pathogenesis of STS and novel therapies that might be explored as treatment options for specific STS histologies.

  10. Advances in regional anaesthesia: A review of current practice, newer techniques and outcomes

    Directory of Open Access Journals (Sweden)

    Christopher Wahal

    2018-01-01

    Full Text Available Advances in ultrasound guided regional anaesthesia and introduction of newer long acting local anaesthetics have given clinicians an opportunity to apply novel approaches to block peripheral nerves with ease. Consequently, improvements in outcomes such as quality of analgesia, early rehabilitation and patient satisfaction have been observed. In this article we will review some of the newer regional anaesthetic techniques, long acting local anaesthetics and adjuvants, and discuss evidence for key outcomes such as cancer recurrence and safety with ultrasound guidance.

  11. The importance of collaboration in the advancement of current and next generation reactors

    International Nuclear Information System (INIS)

    Jackson, Kate; Goossen, John; Anness, Mike; Meston, Tom

    2010-01-01

    The sections of the contribution are as follows: Tradition of innovation. Growing demand for nuclear power; Collaboration drivers; Responses. Knowledge transfer and management is critical. What kind of focus? Equipment reliability. Advanced repair, replacement and construction approaches. Materials. Plant safety margins. Spent fuel management. Examples of European collaboration. Zorita materials examination. Collaboration in the development of next generation reactors; Westinghouse R and D priorities; A look to the future. (P.A.)

  12. Marijuana and actual driving performance

    Science.gov (United States)

    1993-11-01

    This report concerns the effects of marijuana smoking on actual driving performance. It presents the results of one pilot and three actual driving studies. The pilot study's major purpose was to establish the THC dose current marijuana users smoke to...

  13. Social Media, Big Data, and Mental Health: Current Advances and Ethical Implications.

    Science.gov (United States)

    Conway, Mike; O'Connor, Daniel

    2016-06-01

    Mental health (including substance abuse) is the fifth greatest contributor to the global burden of disease, with an economic cost estimated to be US $2.5 trillion in 2010, and expected to double by 2030. Developing information systems to support and strengthen population-level mental health monitoring forms a core part of the World Health Organization's Comprehensive Action Plan 2013-2020. In this paper, we review recent work that utilizes social media "big data" in conjunction with associated technologies like natural language processing and machine learning to address pressing problems in population-level mental health surveillance and research, focusing both on technological advances and core ethical challenges.

  14. Advanced National Seismic System—Current status, development opportunities, and priorities for 2017–2027

    Science.gov (United States)

    ,

    2017-05-25

    SummaryEarthquakes pose a threat to the safety of over 143 million people living in the United States. Earthquake impacts can be significantly reduced if communities understand their risk and take proactive steps to mitigate that risk. The Advanced National Seismic System (ANSS) is a cooperative effort to collect and analyze seismic and geodetic data on earthquakes, issue timely and reliable notifications of their occurrence and impacts, and provide data for earthquake research and the hazard and risk assessments that are the foundation for creating an earthquakeresilient nation.

  15. Modelling marine sediment biogeochemistry: Current knowledge gaps, challenges, and some methodological advice for advancement

    DEFF Research Database (Denmark)

    Lessin, Gennadi; Artioli, Yuri; Almroth-Rosell, Elin

    2018-01-01

    -pronged approach for the advancement of benthic and benthic-pelagic modelling, essential for improved understanding, management and prediction of the marine environment. This includes: (A) Development of a traceable and hierarchical framework for benthic-pelagic models, which will facilitate integration among...... models, reduce risk of bias, and clarify model limitations; (B) extended cross-disciplinary approach to promote effective collaboration between modelling and empirical scientists of various backgrounds and better involvement of stakeholders and end-users; (C) a common vocabulary for terminology used...

  16. Development of Long-Pulse Heating and Current Drive Actuators and Operational Techniques Compatible with a High-Z Divertor and First Wall

    Energy Technology Data Exchange (ETDEWEB)

    Wang, Guiding [Univ. of California, Los Angeles, CA (United States)

    2017-11-02

    Accurate measurement of the edge electron density profile is essential to optimizing antenna coupling and assessment of impurity contamination in studying long-pulse plasma heating and current drive in fusion devices. Measurement of the edge density profile has been demonstrated on the US fusion devices such as C-Mod, DIII-D, and TFTR amongst many devices, and has been used for RF loading and impurity modeling calculations for many years. University of Science and Technology of China (USTC) has recently installed a density profile reflectometer system on the EAST fusion device at the Institute of Plasma Physics, Chinese Academy of Sciences in China based on the University of California Los Angeles (UCLA)-designed reflectometer system on the DIII-D fusion device at General Atomics Company in San Diego, California. UCLA has been working with USTC to optimize the existing microwave antenna, waveguide system, microwave electronics, and data analysis to produce reliable edge density profiles. During the past budget year, progress has been made in all three major areas: effort to achieve reliable system operations under various EAST operational conditions, effort to optimize system performance, and effort to provide quality density profiles into EAST’s database routinely.

  17. Current advances and challenges in microfluidic free-flow electrophoresis-A critical review.

    Science.gov (United States)

    Novo, Pedro; Janasek, Dirk

    2017-10-23

    The research field on microfluidic free-flow electrophoresis has developed vast amounts of devices, methods, applications and raised new questions, often in analogy to conventional techniques from which it derives. Most efforts have been employed on device development and a myriad of architectures and fabrication techniques have been reported using simple proof-of-principle separations. As technological aspects reach a quite mature state, researchers' new challenges include the development of protocols for the separation of complex mixtures, as required in the fields of application. The success of this effort is extremely dependent on the capability to transfer the device's fabrication to an industrial setting as well as to ensure interfacing simplicity, namely at the solutions' supply and collection, and actuation such as electric potential application and temperature control. Other advanced applications such as direct interfacing to downstream systems such as mass spectrometry, integration of sensing and feedback controls will require further development in the laboratory. In this review we provide an overview on the field, from basic concepts, through advanced developments both in the theoretical and experimental arenas, and addressing the above details. A comprehensive survey of designs, materials and applications is presented with particular highlights to most recent developments, namely the integration of electrodes, flow control and hyphenation of microfluidic free-flow electrophoresis with other techniques. Copyright © 2017 Elsevier B.V. All rights reserved.

  18. Advanced molecular diagnostic techniques for detection of food-borne pathogens: Current applications and future challenges.

    Science.gov (United States)

    Umesha, S; Manukumar, H M

    2018-01-02

    The elimination of disease-causing microbes from the food supply is a primary goal and this review deals with the overall techniques available for detection of food-borne pathogens. Now-a-days conventional methods are replaced by advanced methods like Biosensors, Nucleic Acid-based Tests (NAT), and different PCR-based techniques used in molecular biology to identify specific pathogens. Bacillus cereus, Staphylococcus aureus, Proteus vulgaris, Escherichia coli, Campylobacter, Listeria monocytogenes, Salmonella spp., Aspergillus spp., Fusarium spp., Penicillium spp., and pathogens are detected in contaminated food items that cause always diseases in human in any one or the other way. Identification of food-borne pathogens in a short period of time is still a challenge to the scientific field in general and food technology in particular. The low level of food contamination by major pathogens requires specific sensitive detection platforms and the present area of hot research looking forward to new nanomolecular techniques for nanomaterials, make them suitable for the development of assays with high sensitivity, response time, and portability. With the sound of these, we attempt to highlight a comprehensive overview about food-borne pathogen detection by rapid, sensitive, accurate, and cost affordable in situ analytical methods from conventional methods to recent molecular approaches for advanced food and microbiology research.

  19. The application of neural network for the advancement of the eddy current testing

    International Nuclear Information System (INIS)

    Sakai, T.; Soneda, N.

    1996-01-01

    All the steam generator (SG) tubes of Japanese pressurized water reactors (PWRs) are inspected by the eddy current testing (ECT) method in every annual scheduled inspection. Here, a neural network system to estimate the class and size of defects from signals obtained by the eddy current testing (ECT) method has been developed. A trajectory of ECT signal is characterized by four representative parameters, and totally eight parameters obtained from two trajectories by different AC current frequencies are used as input parameters for neutral networks. A probabilistic descent method is employed to minimize the error at the learning process of neural networks. It is indicated that using multiple neutral networks which are separately responsible to each class of defects is effective to the improvement of their estimation accuracy. And, it is demonstrated that the neural network system which the authors developed can estimate the class and size of defects from unlearned trajectories with high accuracy

  20. Electric drives

    CERN Document Server

    Boldea, Ion

    2005-01-01

    ENERGY CONVERSION IN ELECTRIC DRIVESElectric Drives: A DefinitionApplication Range of Electric DrivesEnergy Savings Pay Off RapidlyGlobal Energy Savings Through PEC DrivesMotor/Mechanical Load MatchMotion/Time Profile MatchLoad Dynamics and StabilityMultiquadrant OperationPerformance IndexesProblemsELECTRIC MOTORS FOR DRIVESElectric Drives: A Typical ConfigurationElectric Motors for DrivesDC Brush MotorsConventional AC MotorsPower Electronic Converter Dependent MotorsEnergy Conversion in Electric Motors/GeneratorsPOWER ELECTRONIC CONVERTERS (PECs) FOR DRIVESPower Electronic Switches (PESs)The

  1. Eddy Current, Magnetic Particle and Hardness Testing, Aviation Quality Control (Advanced): 9227.04.

    Science.gov (United States)

    Dade County Public Schools, Miami, FL.

    This unit of instruction includes the principles of eddy current, magnetic particle and hardness testing; standards used for analyzing test results; techniques of operating equipment; interpretation of indications; advantages and limitations of these methods of testing; care and calibration of equipment; and safety and work precautions. Motion…

  2. Chronopotentiometry for the advanced current-voltage characterisation of bipolar membranes

    NARCIS (Netherlands)

    Wilhelm, F.G.; van der Vegt, N.F.A.; Wessling, Matthias; Strathmann, H.

    2001-01-01

    Compared to steady-state current¿voltage curves, chronopotentiometric measurements allow us to distinguish the contributions to the overall electric potential difference across a bipolar membrane. In this paper, the characteristic values of the electric potential difference across the bipolar

  3. Methods for quantification of soil-transmitted helminths in environmental media: current techniques and recent advances

    Science.gov (United States)

    Collender, Philip A.; Kirby, Amy E.; Addiss, David G.; Freeman, Matthew C.; Remais, Justin V.

    2015-01-01

    Limiting the environmental transmission of soil-transmitted helminths (STH), which infect 1.5 billion people worldwide, will require sensitive, reliable, and cost effective methods to detect and quantify STH in the environment. We review the state of the art of STH quantification in soil, biosolids, water, produce, and vegetation with respect to four major methodological issues: environmental sampling; recovery of STH from environmental matrices; quantification of recovered STH; and viability assessment of STH ova. We conclude that methods for sampling and recovering STH require substantial advances to provide reliable measurements for STH control. Recent innovations in the use of automated image identification and developments in molecular genetic assays offer considerable promise for improving quantification and viability assessment. PMID:26440788

  4. Entanglement in continuous-variable systems: recent advances and current perspectives

    Energy Technology Data Exchange (ETDEWEB)

    Adesso, Gerardo [Dipartimento di Fisica, Universita degli Studi di Roma ' La Sapienza' , Piazzale Aldo Moro 5, I-00185 Rome (Italy); Illuminati, Fabrizio [Dipartimento di Matematica e Informatica, Universita degli Studi di Salerno, Via Ponte don Melillo, I-84084 Fisciano (Italy)

    2007-07-13

    We review the theory of continuous-variable entanglement with special emphasis on foundational aspects, conceptual structures and mathematical methods. Much attention is devoted to the discussion of separability criteria and entanglement properties of Gaussian states, for their great practical relevance in applications to quantum optics and quantum information, as well as for the very clean framework that they allow for the study of the structure of nonlocal correlations. We give a self-contained introduction to phase-space and symplectic methods in the study of Gaussian states of infinite-dimensional bosonic systems. We review the most important results on the separability and distillability of Gaussian states and discuss the main properties of bipartite entanglement. These include the extremal entanglement, minimal and maximal, of two-mode mixed Gaussian states, the ordering of two-mode Gaussian states according to different measures of entanglement, the unitary (reversible) localization and the scaling of bipartite entanglement in multimode Gaussian states. We then discuss recent advances in the understanding of entanglement sharing in multimode Gaussian states, including the proof of the monogamy inequality of distributed entanglement for all Gaussian states. Multipartite entanglement of Gaussian states is reviewed by discussing its qualification by different classes of separability, and the main consequences of the monogamy inequality, such as the quantification of genuine tripartite entanglement in three-mode Gaussian states, the promiscuous nature of entanglement sharing in symmetric Gaussian states and the possible coexistence of unlimited bipartite and multipartite entanglement. We finally review recent advances and discuss possible perspectives on the qualification and quantification of entanglement in non-Gaussian states, a field of research that is to a large extent yet to be explored.

  5. A model of the plasma flow and current in Saturn's polar ionosphere under conditions of strong Dungey cycle driving

    Directory of Open Access Journals (Sweden)

    C. M. Jackman

    2006-05-01

    Full Text Available We propose a simple model of the flow and currents in Saturn's polar ionosphere. This model is motivated by theoretical reasoning, and guided quantitatively by in situ field and flow data from space missions, ground-based IR Doppler measurements, and Hubble Space Telescope images. The flow pattern consists of components which represent (1 plasma sub-corotation in the middle magnetosphere region resulting from plasma pick-up and radial transport from internal sources; (2 the Vasyliunas-cycle of internal plasma mass-loss down the magnetospheric tail at higher latitudes; and (3 the polar Dungey-cycle flow driven by the solar wind interaction. Upstream measurements of the interplanetary magnetic field (IMF indicate the occurrence of both extended low-field rarefaction intervals with essentially negligible Dungey-cycle flow, and few-day high-field compression regions in which the Dungey-cycle voltage peaks at a few hundred kV. Here we model the latter conditions when the Dungey-cycle is active, advancing on previous axi-symmetric models which may be more directly applicable to quiet conditions. For theoretical convenience the overall flow pattern is constructed by adding together two components - a purely rotational flow similar to previous axi-symmetric models, and a sun-aligned twin vortex representing the dawn-dusk asymmetry effects associated with the Vasyliunas-and Dungey-cycle flows. We calculate the horizontal ionospheric current associated with the flow and the field-aligned current from its divergence. These calculations show that a sheet of upward-directed field-aligned current flows at the boundary of open field lines which is strongly modulated in local-time by the Dungey-cycle flows. We then consider implications of the field-aligned current for magnetospheric electron acceleration and aurorae using two plasma source populations (hot outer magnetospheric electrons and cool dense magnetosheath electrons. Both sources display a

  6. Current role of non-anesthesiologist administered propofol sedation in advanced interventional endoscopy

    DEFF Research Database (Denmark)

    Burtea, Daniela Elena; Dimitriu, Anca; Maloş, Anca Elena

    2015-01-01

    the patients and medical personnel. Current guidelines support the use of propofol sedation, which has the same rate of adverse effects as traditional sedation with benzodiazepines and/or opioids, but decreases the procedural and recovery time. Non-anesthesiologist administered propofol sedation has become......, improved satisfaction for patients and doctors, as well as decreased recovery and discharge time. Despite the advantages of non-anesthesiologist administered propofol, there is still a continuous debate related to the successful generalization of the procedures....

  7. Anxiety and depression in patients with advanced macular degeneration: current perspectives

    Directory of Open Access Journals (Sweden)

    Cimarolli VR

    2015-12-01

    Full Text Available Verena R Cimarolli,1 Robin J Casten,2 Barry W Rovner,3–5 Vera Heyl,6 Silvia Sörensen,7,8 Amy Horowitz9 1Research Institute on Aging, Jewish Home Lifecare, New York, NY, USA; 2Department of Psychiatry and Human Behavior, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA; 3Department of Neurology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA; 4Department of Psychiatry, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA; 5Department of Ophthalmology, Sidney Kimmel Medical College at Thomas Jefferson University, Philadelphia, PA, USA; 6Institute of Special Education, University of Education, Heidelberg, Germany; 7Warner School of Education and Human Development, University of Rochester, Rochester, NY, USA; 8Department of Ophthalmology, Flaum Eye Institute, University of Rochester School of Medicine and Dentistry, Rochester, NY, USA; 9Graduate School of Social Service, Fordham University, New York, NY, USA Abstract: Age-related macular degeneration (AMD – despite advances in prevention and medical treatment options – remains prevalent among older adults, often resulting in functional losses that negatively affect the mental health of older adults. In particular, the prevalence of both anxiety and depression in patients with AMD is high. Along with medical treatment options, low vision rehabilitation and AMD-specific behavioral and self-management programs have been developed and have demonstrated effectiveness in improving the mental health of AMD patients. This article reviews the prevalence of anxiety and depression in patients with advanced AMD, discusses potential mechanisms accounting for the development of depression and anxiety in AMD patients, presents the state-of the-art of available interventions for addressing anxiety and depression in AMD patients, and delineates recommendations for eye care professionals regarding how to

  8. Treatment patterns of advanced malignant melanoma (stage III-IV) - A review of current standards in Europe.

    Science.gov (United States)

    Harries, Mark; Malvehy, Josep; Lebbe, Céleste; Heron, Louise; Amelio, Justyna; Szabo, Zsolt; Schadendorf, Dirk

    2016-06-01

    With the recent emergence of immunotherapies and novel targeted treatments for advanced and metastatic melanoma such as selective B-Raf inhibitors and checkpoint inhibitors, the treatment landscape in Europe has changed considerably. The aim of this review was to provide an overview of current treatment pathways in Europe for the treatment of advanced melanoma, unresectable stage III-IV. A literature search of four databases was conducted to identify publications reporting on the treatment patterns of advanced and metastatic melanoma (stage III-IV) in European populations. Seven full-text publications and two conference abstracts reported on observational studies of melanoma treatment practices in France, Italy and the United Kingdom. Treatment patterns were identified for two time periods: 2005-2009 and 2011-2012. Common treatments reported for both periods included chemotherapy with dacarbazine, fotemustine or temozolomide. The main differences between the two periods were the introduction and prescription of immunotherapy ipilimumab and targeted therapy vemurafenib between 2011 and 2012. Across the three countries studied, the types of treatments prescribed between 2005 and 2009 were relatively similar, however, with noticeable differences in the frequency and priority of administration. Treatment practices for advanced melanoma vary markedly across different European countries and continue to evolve with the introduction of new therapies. The results of this review highlight a considerable evidence gap with regards to recent treatment patterns for advanced melanoma in Europe, especially post-2011 after the introduction of novel therapeutic agents, and more recently with the introduction of programmed cell death 1 inhibitors. Copyright © 2016 Elsevier Ltd. All rights reserved.

  9. Genome and metabolic engineering in non-conventional yeasts: Current advances and applications

    Directory of Open Access Journals (Sweden)

    Ann-Kathrin Löbs

    2017-09-01

    Full Text Available Microbial production of chemicals and proteins from biomass-derived and waste sugar streams is a rapidly growing area of research and development. While the model yeast Saccharomyces cerevisiae is an excellent host for the conversion of glucose to ethanol, production of other chemicals from alternative substrates often requires extensive strain engineering. To avoid complex and intensive engineering of S. cerevisiae, other yeasts are often selected as hosts for bioprocessing based on their natural capacity to produce a desired product: for example, the efficient production and secretion of proteins, lipids, and primary metabolites that have value as commodity chemicals. Even when using yeasts with beneficial native phenotypes, metabolic engineering to increase yield, titer, and production rate is essential. The non-conventional yeasts Kluyveromyces lactis, K. marxianus, Scheffersomyces stipitis, Yarrowia lipolytica, Hansenula polymorpha and Pichia pastoris have been developed as eukaryotic hosts because of their desirable phenotypes, including thermotolerance, assimilation of diverse carbon sources, and high protein secretion. However, advanced metabolic engineering in these yeasts has been limited. This review outlines the challenges of using non-conventional yeasts for strain and pathway engineering, and discusses the developed solutions to these problems and the resulting applications in industrial biotechnology.

  10. Current advances in tissue repair and regeneration: the future is bright.

    Science.gov (United States)

    Ninov, Nikolay; Yun, Maximina H

    2015-04-01

    The fifth EMBO conference on 'The Molecular and Cellular Basis of Regeneration and Repair' took place in the peaceful coastal town of Sant Feliu de Guixols (Spain) on September 2014. The meeting was organised by Emili Saló (U. Barcelona, Spain), Kimberly Mace (U. Manchester, UK), Patrizia Ferretti (University College London, UK) and Michael Brand (Centre for Regenerative Therapies Dresden, Germany) and received the generous support of Society for Developmental Biology, The Company of Biologists, Centre for Regenerative Therapies Dresden, Garland Science and the journals Regeneration and Cell Signalling. The natural surroundings provided an inspiring setting for 185 researchers from all over the world to share their latest findings and views on the field. The conference showcased the great diversity of model organisms used for studying regeneration and tissue repair, including invertebrate and vertebrate species (Fig. 1). Importantly, this diversity in animal models allowed for a global overview of the mechanisms that promote regeneration. In addition, it highlighted some of the unique aspects that confer differences in regenerative capacities among different species. These differences might lie in each of the different steps involved in performing regeneration, including triggering the regenerative response, controlling cellular plasticity, re-stablishing the correct tissue patterns, as well as determining the roles of extrinsic factors, such as the role of inflammation in regeneration. A deeper understanding of these processes in the naturally regenerating species is a prerequisite for advancing the field of regenerative medicine and tissue repair in humans.

  11. Current status of decommissioning projects and their strategies in advanced countries

    Energy Technology Data Exchange (ETDEWEB)

    Chung, U. S.; Lee, K. W.; Hwang, D. S.; Park, S. K.; Hwang, S. T.; Paik, S. T.; Park, J. H.; Choi, Y. D.; Chung, K. H.; Lee, K. I.; Hong, S. B

    2007-06-15

    At the Korea Atomic Energy Research Institute(KAERI), two projects for decommissioning of the research reactors and uranium conversion plant are carried out. The number of nuclear facilities to be dismantled will be much increased in future and the decommissioning industries will be enlarged. Keeping pace with this increasing tendency, each country formulated their own strategies and regulation systems, and applied their own technologies. The international organizations such as the IAEA and the OECD/NEA also prepared standards in technologies and regulation upon decommissioning and recommended to adopt them to the decommissioning projects. These strategies and technologies are very different country by country due to the different site dependent conditions and it will not be reasonable to evaluate their merits and weakness. The world wide status of the decommissioning, highlighted on that of 5 countries of USA, UK, France, Germany and Japan because they are advanced counties in nuclear industries, are summarized and their site specific conditions are evaluated. The scopes of the evaluation are decommissioning strategies, licensing procedures and requirements focused on decommissioning plan, waste management, technology development and so on. The detailed decommissioning progresses of several typical example sites were introduced. The activities on decommissioning field of the international organization, increased according to the enlarged decommissioning industries, are also summarized.

  12. Current major advances in the regulation of milk protein gene expression.

    Science.gov (United States)

    Qian, Xi; Zhao, Feng-Qi

    2014-01-01

    During lactation, functionally differentiated mammary epithelial cells convert circulating nutrients into various milk components, providing all essential nutrients for the growth and development of mammal neonates. One of the major milk components is milk protein, which includes the casein and whey proteins. Regulation of milk protein gene expression is dependent on hormonal and developmental cues that modulate the activity of specific transcription factors and change the chromatin structure in mammary epithelial cells. Understanding the underlying mechanisms involved in mammary-specific milk protein gene regulation will help improve the yield, quality, and efficiency of milk production and identify important signaling factors and pathways involved in mammary development, differentiation, lactation, and disease. In this review we first review advances in the understanding of the regulatory mechanisms of milk protein genes by hormones, growth factors, and the extracellular matrix, with a focus on transcriptional regulation. We then discuss the relationship between chromatin structure and milk protein gene expression from an epigenetic perspective. Finally, we summarize recent achievements using the mammary gland as a bioreactor for producing pharmaceutical proteins for human use.

  13. CURRENT APPROACHES TO CONSERVATIVE AND COMBINED TREATMENT FOR LOCALLY ADVANCED LARYNGEAL CANCER

    Directory of Open Access Journals (Sweden)

    V. A. Pankratov

    2013-01-01

    Full Text Available The comparative analysis of results of conservative and combined treatment was carried out. The study group consisted of 400 patients with stage T3–4N0–3M0 laryngeal cancer who received concurrent chemotherapy and radiation therapy in combination with various physical radiomodifyers. The control group comprised 920 patients treated with the same technique but without systemic polychemotherapy. The 5-year relapse-free and overall survival rates were significantly higher in the study group than in the control group  (concervative treatment: 71 % and 86 % versus 37 % and 64.8 %, respectively, р<0,001 and combined treatment: 80 % and 83 % versus 47.4 % and 52 %, respectively(р<0,001. The functional organ was preserved in 71.2 % of locally advanced laryngeal cancer patients treated conservatively compared to 37.0 % of the control group patients. Oprgan-preserving surgeries were performed in 30.5% and 23%, respectively. The total number of patients with the larynx preservation was 50 % of the stydy group and 31.6 % of the control group.

  14. Evolution, current status and advances in application of platelet concentrate in periodontics and implantology.

    Science.gov (United States)

    Agrawal, Amit Arvind

    2017-05-16

    Platelet concentrates (PC) [platelet-rich plasma (PRP) and platelet-rich fibrin (PRF)] are frequently used for surgical procedures in medical and dental fields, particularly in oral and maxillofacial surgery, plastic surgery and sports medicine. The objective of all these technologies is to extract all the elements from a blood sample that could be used to improve healing and promote tissue regeneration. Although leukocyte rich and leukocyte poor PRP's have their own place in literature, the importance of non-platelet components in a platelet concentrate remains a mystery. PC have come a long way since its first appearance in 1954 to the T-PRF, A-PRF and i-PRF introduced recently. These PC find varied applications successfully in periodontics and implant dentistry as well. However, the technique of preparation, standing time, transfer process, temperature of centrifuge, vibration, etc ., are the various factors for the mixed results reported in the literature. Until the introduction of a proper classification of terminologies, the PC were known by different names in different countries and by different commercial companies which also created a lot of confusion. This review intends to clarify all these confusion by briefing the exact evolution of PC, their preparation techniques, recent advances and their various clinical and technical aspects and applications.

  15. Synthetic biology and molecular genetics in non-conventional yeasts: Current tools and future advances.

    Science.gov (United States)

    Wagner, James M; Alper, Hal S

    2016-04-01

    Coupling the tools of synthetic biology with traditional molecular genetic techniques can enable the rapid prototyping and optimization of yeast strains. While the era of yeast synthetic biology began in the well-characterized model organism Saccharomyces cerevisiae, it is swiftly expanding to include non-conventional yeast production systems such as Hansenula polymorpha, Kluyveromyces lactis, Pichia pastoris, and Yarrowia lipolytica. These yeasts already have roles in the manufacture of vaccines, therapeutic proteins, food additives, and biorenewable chemicals, but recent synthetic biology advances have the potential to greatly expand and diversify their impact on biotechnology. In this review, we summarize the development of synthetic biological tools (including promoters and terminators) and enabling molecular genetics approaches that have been applied in these four promising alternative biomanufacturing platforms. An emphasis is placed on synthetic parts and genome editing tools. Finally, we discuss examples of synthetic tools developed in other organisms that can be adapted or optimized for these hosts in the near future. Copyright © 2015 Elsevier Inc. All rights reserved.

  16. Comparative investigation of the economics of seawater desalting based on current and advanced distillation concepts

    International Nuclear Information System (INIS)

    Glueckstern, P.; Reed, S.A.

    1976-01-01

    A reassessment of desalting plant design and product water cost based on current technology and energy and equipment costs has been made. Plant sizes in the range of 1 to 200 Mgd utilizing the multistage flash (MSF) and the vertical tube evaporator (VTE) were investigated. Process steam was assumed to be supplied by large nuclear dual-purpose plants or from fossil-fired low-pressure boilers. Plants applying the pH control method versus the threshold pretreatment method were compared. The potential benefits of applying low cost aluminum tubing in low-temperature VTE plants were also investigated

  17. Harmonic Distortion Performance of Multi Three-Phase SCR-Fed Drive Systems with Controlled DC-Link Current under Unbalanced Grid

    DEFF Research Database (Denmark)

    Soltani, Hamid; Davari, Pooya; Blaabjerg, Frede

    2017-01-01

    effective factors on the drives harmonic performance are discussed. Moreover, the analysis is performed by considering an Equally-Pulse-Space (EPS) firing approach on the SCRs. Obtained simulation and experimental results verify the proposed theoretical analysis and mathematical modeling....

  18. Extrapolating power-ramp performance criteria for current and advanced CANDU fuels

    International Nuclear Information System (INIS)

    Tayal, M.; Chassie, G.G.

    2000-06-01

    To improve the precision and accuracy of power-ramp performance criteria for high-burnup fuel, we have examined in-reactor fuel performance data as well as out-reactor test data. The data are consistent with some of the concepts used in the current formulations for defining fuel failure thresholds, such as size of power-ramp and extent of burnup. Our review indicates that there is a need to modify some other aspects of the current formulations; therefore, a modified formulation is presented in this paper. The improvements mainly concern corrodent concentration and its relationships with threshold stress for failure. The new formulation is consistent with known and expected trends such as strength of Zircaloy in corrosive environment, timing of the release of fission products to the pellet-to-sheath gap, CANLUB coating, and fuel burnup. Because of the increased precision and accuracy, the new formulation is better able to identify operational regimes that are at risk of power-ramp failures; this predictive ability provides enhanced protection to fuel against power-ramp defects. At die same time, by removing unnecessary conservatisms in other areas, the new formulation permits a greater range of defect-free operational envelope as well as larger operating margins in regions that are, in fact, not prone to power-ramp failures. (author)

  19. Recent advances in high current vacuum arc ion sources for heavy ion fusion

    CERN Document Server

    Qi Nian Sheng; Prasad, R R; Krishnan, M S; Anders, A; Kwan, J; Brown, I

    2001-01-01

    For a heavy ion fusion induction linac driver, a source of heavy ions with charge states 1+-3+, approx 0.5 A current beams, approx 20 mu s pulse widths and approx 10 Hz repetition rates is required. Thermionic sources have been the workhorse for the Heavy Ion Fusion (HIF) program to date, but suffer from heating problems for large areas and contamination. They are limited to low (contact) ionization potential elements and offer relatively low ion fluxes with a charge state limited to 1+. Gas injection sources suffer from partial ionization and deleterious neutral gas effects. The above shortcomings of the thermionic ion sources can be overcome by a vacuum arc ion source. The vacuum arc ion source is a good candidate for HIF applications. It is capable of providing ions of various elements and different charge states in short and long pulse bursts and high beam current density. Under a Phase-I STTR from DOE, the feasibility of the vacuum arc ion source for the HIF applications was investigated. We have modifie...

  20. ADVANCED SIMULATION CAPABILITY FOR ENVIRONMENTAL MANAGEMENT – CURRENT STATUS AND PHASE II DEMONSTRATION RESULTS

    Energy Technology Data Exchange (ETDEWEB)

    Seitz, Roger; Freshley, Mark D.; Dixon, Paul; Hubbard, Susan S.; Freedman, Vicky L.; Flach, Gregory P.; Faybishenko, Boris; Gorton, Ian; Finsterle, Stefan A.; Moulton, John D.; Steefel, Carl I.; Marble, Justin

    2013-06-27

    The U.S. Department of Energy (USDOE) Office of Environmental Management (EM), Office of Soil and Groundwater, is supporting development of the Advanced Simulation Capability for Environmental Management (ASCEM). ASCEM is a state-of-the-art scientific tool and approach for understanding and predicting contaminant fate and transport in natural and engineered systems. The modular and open source high-performance computing tool facilitates integrated approaches to modeling and site characterization that enable robust and standardized assessments of performance and risk for EM cleanup and closure activities. The ASCEM project continues to make significant progress in development of computer software capabilities with an emphasis on integration of capabilities in FY12. Capability development is occurring for both the Platform and Integrated Toolsets and High-Performance Computing (HPC) Multiprocess Simulator. The Platform capabilities provide the user interface and tools for end-to-end model development, starting with definition of the conceptual model, management of data for model input, model calibration and uncertainty analysis, and processing of model output, including visualization. The HPC capabilities target increased functionality of process model representations, toolsets for interaction with Platform, and verification and model confidence testing. The Platform and HPC capabilities are being tested and evaluated for EM applications in a set of demonstrations as part of Site Applications Thrust Area activities. The Phase I demonstration focusing on individual capabilities of the initial toolsets was completed in 2010. The Phase II demonstration completed in 2012 focused on showcasing integrated ASCEM capabilities. For Phase II, the Hanford Site deep vadose zone (BC Cribs) served as an application site for an end-to-end demonstration of capabilities, with emphasis on integration and linkages between the Platform and HPC components. Other demonstrations

  1. Current Advances in L-DOPA and DOPA-Peptidomimetics: Chemistry, Applications and Biological Activity.

    Science.gov (United States)

    Bizzarri, Bruno Mattia; Tortolini, Silvia; Rotelli, Luca; Botta, Giorgia; Saladino, Raffaele

    2015-01-01

    L-3,4-Dihydroxyphenylalanine [2-amino-3-(3,4-dihydroxyphenyl) propanoic acid (L-DOPA) is a natural constituent of animal and plant tissue derived from post-translational modification of the amino acid tyrosine. L-DOPA is modified during metabolism to catecholamine neurotransmitters, noradrenaline and adrenaline, which are characterized by different biological activities. L-DOPA has been the first drug of choice in the therapy of Parkinson's disease that is a progressive neurodegenerative disorder involving the loss of dopaminergic neurons of substantia nigra pars compacta. The social and economic impact of these diseases is very high due to the progressive aging of the population. This review focuses on the biological effect of LDOPA, as well as on the synthesis of L-DOPA derivatives and their application in central nervous system diseases. Among them, L-DOPA-containing peptides (L-DOPA-Pep) show important biological and pharmacological activities. For example, L-DOPA analogues of the alpha-factor interact with models of the G protein-coupled receptor, inhibit the oxidation of low-density lipoproteins, and are used for improving L-DOPA absorption in long-term treatment of Parkinson's disease and as skin moisturizer in cosmetic compositions. Moreover, L-DOPA residues in proteins provide reactive tools for the preparation of adhesives and coatings materials. Usually, L-DOPA-Pep is prepared by traditional liquid or solid state procedures starting from simple amino acids. Recently, selective side-chain modifications of pre-formed peptides have also been reported both for linear and branched peptides. Here, we describe the recent advances in the synthesis of L-DOPA and dopa-peptidomimetics and their biological and pharmacological activities, focusing the attention on new synthetic procedures and biological mechanism of actions.

  2. Hall voltage drives pulsing counter-currents of the sliding charge density wave and of quantized normal carriers at self-filled Landau levels

    Science.gov (United States)

    Orlov, Andrey P.; Sinchenko, Aleksander A.; Monceau, Pierre; Brazovskii, Serguei; Latyshev, Yuri I.

    2017-11-01

    Remnant pockets of carriers left over after formation of a charge density wave (CDW) were brought, by virtue of transverse electric and magnetic fields, to a current-carrying state at quantized Landau Levels. The generated Hall voltage polarizes and puts to sliding the flexible CDW background. The screening from the CDW allows for a so strong redistribution of normal electrons density under the action of the Lorentz force alone, that an integer filling of the lowest Landau level might be reached at one edge at the expense of the full depletion at another edge of the Hall bar. With the Hall field exceeding the sliding threshold, the regime of exactly compensated collective and normal counter-currents develops in the open-circuit direction across the bar. The annihilation of the two currents proceeds via a regular sequence of phase slips which are the space-time vortices of the CDW phase around the enforced amplitude nodes. The resulting spontaneous generation of coherent high ( GHz) frequency signals was detected by observations of multiple Shapiro steps. This picture results from studies of micron-sized Hall bars in crystals of NbSe3 prepared by means of focused ion beams. The interpretation is confirmed and illustrated by a numerical solution of the derived equations. The depinning pulse propagates from edges to the bulk and the sliding sets in, accompanied by the generation of periodic phase slips near the Hall bar edge where the CDW phase is advanced in steps of 2π at expense of the CDW amplitude passing through zero.

  3. Advanced Simulation Capability for Environmental Management - Current Status and Phase II Demonstration Results - 13161

    Energy Technology Data Exchange (ETDEWEB)

    Seitz, Roger R.; Flach, Greg [Savannah River National Laboratory, Savannah River Site, Bldg 773-43A, Aiken, SC 29808 (United States); Freshley, Mark D.; Freedman, Vicky; Gorton, Ian [Pacific Northwest National Laboratory, MSIN K9-33, P.O. Box 999, Richland, WA 99352 (United States); Dixon, Paul; Moulton, J. David [Los Alamos National Laboratory, MS B284, P.O. Box 1663, Los Alamos, NM 87544 (United States); Hubbard, Susan S.; Faybishenko, Boris; Steefel, Carl I.; Finsterle, Stefan [Lawrence Berkeley National Laboratory, 1 Cyclotron Road, MS 50B-4230, Berkeley, CA 94720 (United States); Marble, Justin [Department of Energy, 19901 Germantown Road, Germantown, MD 20874-1290 (United States)

    2013-07-01

    The U.S. Department of Energy (US DOE) Office of Environmental Management (EM), Office of Soil and Groundwater, is supporting development of the Advanced Simulation Capability for Environmental Management (ASCEM). ASCEM is a state-of-the-art scientific tool and approach for understanding and predicting contaminant fate and transport in natural and engineered systems. The modular and open source high-performance computing tool facilitates integrated approaches to modeling and site characterization that enable robust and standardized assessments of performance and risk for EM cleanup and closure activities. The ASCEM project continues to make significant progress in development of computer software capabilities with an emphasis on integration of capabilities in FY12. Capability development is occurring for both the Platform and Integrated Tool-sets and High-Performance Computing (HPC) Multi-process Simulator. The Platform capabilities provide the user interface and tools for end-to-end model development, starting with definition of the conceptual model, management of data for model input, model calibration and uncertainty analysis, and processing of model output, including visualization. The HPC capabilities target increased functionality of process model representations, tool-sets for interaction with Platform, and verification and model confidence testing. The Platform and HPC capabilities are being tested and evaluated for EM applications in a set of demonstrations as part of Site Applications Thrust Area activities. The Phase I demonstration focusing on individual capabilities of the initial tool-sets was completed in 2010. The Phase II demonstration completed in 2012 focused on showcasing integrated ASCEM capabilities. For Phase II, the Hanford Site deep vadose zone (BC Cribs) served as an application site for an end-to-end demonstration of capabilities, with emphasis on integration and linkages between the Platform and HPC components. Other demonstrations

  4. Advanced Simulation Capability for Environmental Management - Current Status and Phase II Demonstration Results - 13161

    International Nuclear Information System (INIS)

    Seitz, Roger R.; Flach, Greg; Freshley, Mark D.; Freedman, Vicky; Gorton, Ian; Dixon, Paul; Moulton, J. David; Hubbard, Susan S.; Faybishenko, Boris; Steefel, Carl I.; Finsterle, Stefan; Marble, Justin

    2013-01-01

    The U.S. Department of Energy (US DOE) Office of Environmental Management (EM), Office of Soil and Groundwater, is supporting development of the Advanced Simulation Capability for Environmental Management (ASCEM). ASCEM is a state-of-the-art scientific tool and approach for understanding and predicting contaminant fate and transport in natural and engineered systems. The modular and open source high-performance computing tool facilitates integrated approaches to modeling and site characterization that enable robust and standardized assessments of performance and risk for EM cleanup and closure activities. The ASCEM project continues to make significant progress in development of computer software capabilities with an emphasis on integration of capabilities in FY12. Capability development is occurring for both the Platform and Integrated Tool-sets and High-Performance Computing (HPC) Multi-process Simulator. The Platform capabilities provide the user interface and tools for end-to-end model development, starting with definition of the conceptual model, management of data for model input, model calibration and uncertainty analysis, and processing of model output, including visualization. The HPC capabilities target increased functionality of process model representations, tool-sets for interaction with Platform, and verification and model confidence testing. The Platform and HPC capabilities are being tested and evaluated for EM applications in a set of demonstrations as part of Site Applications Thrust Area activities. The Phase I demonstration focusing on individual capabilities of the initial tool-sets was completed in 2010. The Phase II demonstration completed in 2012 focused on showcasing integrated ASCEM capabilities. For Phase II, the Hanford Site deep vadose zone (BC Cribs) served as an application site for an end-to-end demonstration of capabilities, with emphasis on integration and linkages between the Platform and HPC components. Other demonstrations

  5. Development and testing of an AC electric drive system for use in a 2-speed transaxle

    Energy Technology Data Exchange (ETDEWEB)

    King, R.D.; Ciccarelli, M.F.; Park, J.N.

    1984-08-01

    An advanced alternating current, AC electric drive system, discussed in this paper, is being developed by General Electric Company for Ford Motor Company as part of the Department of Energy sponsored ''Advanced Electric Vehicle Powertrain Program.''

  6. Comparison of advanced optical imaging techniques with current otolaryngology diagnostics for improved middle ear assessment (Conference Presentation)

    Science.gov (United States)

    Nolan, Ryan M.; Shelton, Ryan L.; Monroy, Guillermo L.; Spillman, Darold R.; Novak, Michael A.; Boppart, Stephen A.

    2016-02-01

    Otolaryngologists utilize a variety of diagnostic techniques to assess middle ear health. Tympanometry, audiometry, and otoacoustic emissions examine the mobility of the tympanic membrane (eardrum) and ossicles using ear canal pressure and auditory tone delivery and detection. Laser Doppler vibrometry provides non-contact vibrational measurement, and acoustic reflectometry is used to assess middle ear effusion using sonar. These technologies and techniques have advanced the field beyond the use of the standard otoscope, a simple tissue magnifier, yet the need for direct visualization of middle ear disease for superior detection, assessment, and management remains. In this study, we evaluated the use of portable optical coherence tomography (OCT) and pneumatic low-coherence interferometry (LCI) systems with handheld probe delivery to standard tympanometry, audiometry, otoacoustic emissions, laser Doppler vibrometry, and acoustic reflectometry. Comparison of these advanced optical imaging techniques and current diagnostics was conducted with a case study subject with a history of unilateral eardrum trauma. OCT and pneumatic LCI provide novel dynamic spatiotemporal structural data of the middle ear, such as the thickness of the eardrum and quantitative detection of underlying disease pathology, which could allow for more accurate diagnosis and more appropriate management than currently possible.

  7. Advances and Current Concepts in the Medical Management of Gastroenteropancreatic Neuroendocrine Neoplasms

    Directory of Open Access Journals (Sweden)

    Krystallenia I. Alexandraki

    2017-01-01

    Full Text Available Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs are rare and heterogeneous group of tumors presenting as localised or metastatic disease and in a subset with distinct clinical syndromes. Treatment is aimed at controlling the functional syndrome, eradicating the tumor, and/or preventing further tumor growth. Surgery is the treatment of choice in removing the primary tumor and/or reducing tumor burden but cannot be applied to all patients. Somatostatin analogs (SS-analogs obtain control of functional syndromes in the majority of GEP-neuroendocrine tumors (NETs; phase III trials have shown that SS-analogs can be used as first-line antiproliferative treatment in patients with slow-growing GEP-NETs. The role of the recently approved serotonin inhibitor, telotristat ethyl, and gastrin receptor antagonist, netazepide, is evolving. Streptozotocin-based chemotherapy has been used for inoperable or progressing pancreatic NENs but the orally administered combination of capecitabine/temozolomide is becoming more popular due to its better tolerability and potential effect in other GEP-NENs. Phase III trials have shown efficacy of molecular targeted therapies in GEP-NETs and of radionuclide treatment in patients with midgut carcinoid tumors expressing somatostatin receptors. Most patients will develop disease progression necessitating further therapeutic options. A combination of currently available treatments along with the molecular signature of each tumor will guide future treatment.

  8. Immunotherapy for Patients with Advanced Urothelial Cancer: Current Evidence and Future Perspectives

    Directory of Open Access Journals (Sweden)

    Clizia Zichi

    2017-01-01

    Full Text Available In recent years, immunotherapy has produced encouraging results in a rapidly increasing number of solid tumors. The responsiveness of bladder cancer to immunotherapy was first established in nonmuscle invasive disease in 1976 with intravesical instillations of bacillus Calmette-Guérin (BCG. Very recently immune checkpoint inhibitors demonstrated good activity and significant efficacy in metastatic disease. In particular the best results were obtained with programmed death-ligand-1 (PD-L1 and programmed death-1 (PD-1 inhibitors, but many other immune checkpoint inhibitors, including anti-cytotoxic T-lymphocyte-associated protein-4 (CTLA-4 antibodies, are currently under investigation in several trials. Simultaneously other therapeutic strategies which recruit an adaptive immune response against tumoral antigens or employ externally manipulated tumor infiltrating lymphocytes might change the natural history of bladder cancer in the near future. This review describes the rationale for the use of immunotherapy in bladder cancer and discusses recent and ongoing clinical trials with checkpoint inhibitors and other novel immunotherapy agents.

  9. The role of germ cell loss during primordial follicle assembly: a review of current advances.

    Science.gov (United States)

    Sun, Yuan-Chao; Sun, Xiao-Feng; Dyce, Paul W; Shen, Wei; Chen, Hong

    2017-01-01

    In most female mammals, early germline development begins with the appearance of primordial germ cells (PGCs), and develops to form mature oocytes following several vital processes. It remains well accepted that significant germ cell apoptosis and oocyte loss takes place around the time of birth. The transition of the ovarian environment from fetal to neonatal, coincides with the loss of germ cells and the timing of follicle formation. All told it is common to lose approximately two thirds of germ cells during this transition period. The current consensus is that germ cell loss can be attributed, at least in part, to programmed cell death (PCD). Recently, autophagy has been implicated as playing a part in germ cell loss during the time of parturition. In this review, we discuss the major opinions and mechanisms of mammalian ovarian PCD during the process of germ cell loss. We also pay close attention to the function of autophagy in germ cell loss, and speculate that autophagy may also serve as a critical and necessary process during the establishment of primordial follicle pool.

  10. Current and advanced NO/sub x/-control technology for coal-fired industrial boilers

    Energy Technology Data Exchange (ETDEWEB)

    1978-12-01

    A NOx-control-technology assessment study of coal-fired industrial boilers was conducted to examine the effectiveness of combustion-modification methods, including low excess air, staged combustion, and burner modifications. Boiler types considered included overfed and underfed stokers, spreader stokers, pulverized-coal and coal-fired cyclone units. Significant variations in NOx emissions occur with boiler type, firing method, and coal type; a relative comparison of emission-control performance, cost, and operational considerations is presented for each method. Baseline (as-found) emissions from grate-fired stokers were shown to be in the range of 200 to 300 ppM. Similarly, as-found emissions from suspension-fired units were quite low (350 to 600 ppM) as compared to comparably designed utility-sized units. Low excess air was shown to be the most effective method on existing units, reducing emissions by approximately 10%. Evaluation of staged combustion and burner modification, however, were limited due to current boiler designs. Major hardware modification/design and implementation are necessary before the potential of these techniques can be fully evaluated. The study emphasized the numerous operational factors that are of major importance to the user in selecting and implementing a combustion-modification program, including energy considerations, incremental capital and operating costs, corrosion, secondary pollutants, and retrofit potential.

  11. Diagnostic of corrosion defects in steam generator tubes using advanced signal processing from Eddy current testing

    International Nuclear Information System (INIS)

    Formigoni, Andre L.; Lopez, Luiz A.N.M.; Ting, Daniel K.S.

    2009-01-01

    Recently, the Brazilian Angra I PWR nuclear power plant went into a programmed shutdown for substitution of its Steam Generator (SG) which life was shortened due to stress corrosion in its tubes. The total cost of investment were around R$724 million. The signals generated during an Eddy-current Testing (ECT) inspection in SG tubes of nuclear plant allows for the localization and dimensioning of defects in the tubes. The defects related with corrosion generate complex signals that are difficult to analyze and are the most common cause in SG replacement in nuclear power plants around the world. The objective of this paper is the development of a methodology that allows for the characterization of corrosion signals by ECT inspections applied in the heat exchangers tubes of SG of a nuclear power plant. In this present work, the aim is to investigate distributed type defects by inducing controlled corrosion in sample tubes of different materials The ECT signals obtained from these samples tubes with corrosion implanted, will be analyzed using Zetec ECT equipment, the MIZ-17ET and its probes. The data acquisition will use a NI PC A/D CARD 700 card and the LabVIEW program. Subsequently, we will apply mathematical tools for signal processing like time windowed Fast Fourier transforms and Wavelets transforms, in MATLAB platform, which will allow effectiveness to remove the noises and to extract representative characteristics for the defect being analyzed. Previously obtained results as well as the proposal for the future work will be presented. (author)

  12. Current advances in mathematical modeling of anti-cancer drug penetration into tumor tissues.

    Science.gov (United States)

    Kim, Munju; Gillies, Robert J; Rejniak, Katarzyna A

    2013-11-18

    Delivery of anti-cancer drugs to tumor tissues, including their interstitial transport and cellular uptake, is a complex process involving various biochemical, mechanical, and biophysical factors. Mathematical modeling provides a means through which to understand this complexity better, as well as to examine interactions between contributing components in a systematic way via computational simulations and quantitative analyses. In this review, we present the current state of mathematical modeling approaches that address phenomena related to drug delivery. We describe how various types of models were used to predict spatio-temporal distributions of drugs within the tumor tissue, to simulate different ways to overcome barriers to drug transport, or to optimize treatment schedules. Finally, we discuss how integration of mathematical modeling with experimental or clinical data can provide better tools to understand the drug delivery process, in particular to examine the specific tissue- or compound-related factors that limit drug penetration through tumors. Such tools will be important in designing new chemotherapy targets and optimal treatment strategies, as well as in developing non-invasive diagnosis to monitor treatment response and detect tumor recurrence.

  13. Current advances in biomarkers for targeted therapy in triple-negative breast cancer

    Directory of Open Access Journals (Sweden)

    Fleisher B

    2016-10-01

    Full Text Available Brett Fleisher,1 Charlotte Clarke,2 Sihem Ait-Oudhia1 1Department of Pharmaceutics, Center for Pharmacometrics and Systems Pharmacology, College of Pharmacy, University of Florida, Orlando, FL, 2Department of Translational Research, UT MD Anderson Cancer Center, Houston, TX, USA Abstract: Triple-negative breast cancer (TNBC is a complex heterogeneous disease characterized by the absence of three hallmark receptors: human epidermal growth factor receptor 2, estrogen receptor, and progesterone receptor. Compared to other breast cancer subtypes, TNBC is more aggressive, has a higher prevalence in African-Americans, and more frequently affects younger patients. Currently, TNBC lacks clinically accepted targets for tailored therapy, warranting the need for candidate biomarkers. BiomarkerBase, an online platform used to find biomarkers reported in clinical trials, was utilized to screen all potential biomarkers for TNBC and select only the ones registered in completed TNBC trials through clinicaltrials.gov. The selected candidate biomarkers were classified as surrogate, prognostic, predictive, or pharmacodynamic (PD and organized by location in the blood, on the cell surface, in the cytoplasm, or in the nucleus. Blood biomarkers include vascular endothelial growth factor/vascular endothelial growth factor receptor and interleukin-8 (IL-­8; cell surface biomarkers include EGFR, insulin-like growth factor binding protein, c-Kit, c-Met, and PD-L1; cytoplasm biomarkers include PIK3CA, pAKT/S6/p4E-BP1, PTEN, ALDH1, and the PIK3CA/AKT/mTOR-related metabolites; and nucleus biomarkers include BRCA1, the glucocorticoid receptor, TP53, and Ki67. Candidate biomarkers were further organized into a “cellular protein network” that demonstrates potential connectivity. This review provides an inventory and reference point for promising biomarkers for breakthrough targeted therapies in TNBC. Keywords: anti-cancer directed pharmacotherapy, difficult

  14. The Development of Perioperative Practices for Liver Transplantation: Advances and Current Trends

    Directory of Open Access Journals (Sweden)

    Merceds Susan Mandell

    2008-09-01

    Full Text Available Transplantation is a young medical specialty that has grown rapidly over the past 50 years. Anesthesiologists, surgeons and hepatologists are all essential partners in the process of determining patient outcome. Each specialty has made landmark improvements in patient outcome. However, there is still variability in practice patterns in each of the 3 major specialties. This review will use a historic perspective to explore the unique forces that shaped specific transplant practices and those that gave rise to differences in perioperative practices. Anesthesiologists and surgeons have made significant improvements in the management of blood loss, and coagulation monitoring and intervention. This has improved operative survival and early patient outcome. Perioperative survival has improved despite a worldwide shortage of donor organs and a trend to transplant sicker patients. A smaller pool of donor organs is required to meet the needs of an expanding waiting list. The innovations to reduce deaths on the transplant wait list are reviewed along with their impact on overall patient outcome. The evolving organ shortage is the pinnacle point in shaping future transplant practices. Currently, institutional-specific practices may be reinforced by the informal “tutorship” that is used to train physicians and by the resources available at each site of practice. However, there is evidence that specific intraoperative practices such as the use of a low central venous pressure, selection of vasopressors and certain surgical techniques can modify patient outcome. Further investigation is needed to determine whether the good or the bad associated with each practice prevails and in what unique circumstance.

  15. Advanced ceramic matrix composite materials for current and future propulsion technology applications

    Science.gov (United States)

    Schmidt, S.; Beyer, S.; Knabe, H.; Immich, H.; Meistring, R.; Gessler, A.

    2004-08-01

    Current rocket engines, due to their method of construction, the materials used and the extreme loads to which they are subjected, feature a limited number of load cycles. Various technology programmes in Europe are concerned, besides developing reliable and rugged, low cost, throwaway equipment, with preparing for future reusable propulsion technologies. One of the key roles for realizing reusable engine components is the use of modern and innovative materials. One of the key technologies which concern various engine manufacturers worldwide is the development of fibre-reinforced ceramics—ceramic matrix composites. The advantages for the developers are obvious—the low specific weight, the high specific strength over a large temperature range, and their great damage tolerance compared to monolithic ceramics make this material class extremely interesting as a construction material. Over the past years, the Astrium company (formerly DASA) has, together with various partners, worked intensively on developing components for hypersonic engines and liquid rocket propulsion systems. In the year 2000, various hot-firing tests with subscale (scale 1:5) and full-scale nozzle extensions were conducted. In this year, a further decisive milestone was achieved in the sector of small thrusters, and long-term tests served to demonstrate the extraordinary stability of the C/SiC material. Besides developing and testing radiation-cooled nozzle components and small-thruster combustion chambers, Astrium worked on the preliminary development of actively cooled structures for future reusable propulsion systems. In order to get one step nearer to this objective, the development of a new fibre composite was commenced within the framework of a regionally sponsored programme. The objective here is to create multidirectional (3D) textile structures combined with a cost-effective infiltration process. Besides material and process development, the project also encompasses the development of

  16. Past, Current and Future of the Advanced Microwave Scanning Radiometer (AMSR) Series

    Science.gov (United States)

    Kachi, M.; Maeda, T.; Ono, N.; Tomii, N.; Kasahara, M.; Mokuno, M.; Sobue, S.

    2017-12-01

    time and quality, transition from AMSR-2 to follow-on mission to continue operational applications and keep long-term data record for climate studies. Currently, JAXA is studying possible payload capability of AMSR-2 follow-on onto the Greenhouse Gases Observation Satellite-3 (GOSAT-3) scheduled to be launched in Japanese Fiscal Year 2022.

  17. Clinical Action against Drunk Driving.

    Directory of Open Access Journals (Sweden)

    Donald A Redelmeier

    2017-02-01

    Full Text Available In advance of a safety campaign on 17 March 2017, Donald Redelmeier and Allan Detsky call on physicians and clinical colleagues to reduce the chances that patients will drive drunk.

  18. Drowsy Driving

    Science.gov (United States)

    ... at least 8 hours. 8-9 Develop good sleeping habits such as sticking to a sleep schedule. If ... K, Howard ME. Cognitive components of simulated driving performance: sleep loss effects and predictors. Accid Anal Prev. 2012; ...

  19. Distracted Driving

    Science.gov (United States)

    ... Communities Toolkit Best Practices Guide Publications Motorcycle Safety Bicycle Safety Publications Global Road Safety Get Email Updates ... study. The Insurance Institute for Highway Safety keeps track of distracted driving laws. 7 As of June ...

  20. HiPER target studies: towards the design of high gain, robust, scalable direct-drive targets with advanced ignition schemes

    Science.gov (United States)

    Atzeni, S.; Schurtz, G.

    2011-06-01

    An essential element of the HiPER project is the design of high gain targets, compatible with high repetition-rate operation and that can be mass produced at low cost. HiPER WP9 (Work Package 9 Requirements analysis for the fusion programme) studied schemes based on direct laser irradiation and advanced ignition (fast ignition and shock ignition), which have potentials for gain in excess of 100 at laser energy of about 1 MJ. To begin with, a very simple target was designed, which could allow for ignition demonstration with a few hundred kJ laser, and can be scaled at higher energy and gain. The ignition requirements have been determined, and crucial issues have been identified. This led to select shock ignition as the main option, since it turns out that all the relevant issues could be tested experimentally at existing facilities in the present decade. WP9 investigated irradiation schemes, target symmetry and stability issues, sensitivity to parameter changes, requirements for beam delivery and focusing and target positioning. Current work is directed towards increasing target robustness, scaling to greater energy, and designing targets for full scale demonstration.

  1. Modeling Nitrogen Losses in Conventional and Advanced Soil-Based Onsite Wastewater Treatment Systems under Current and Changing Climate Conditions.

    Science.gov (United States)

    Morales, Ivan; Cooper, Jennifer; Amador, José A; Boving, Thomas B

    2016-01-01

    Most of the non-point source nitrogen (N) load in rural areas is attributed to onsite wastewater treatment systems (OWTS). Nitrogen compounds cause eutrophication, depleting the oxygen in marine ecosystems. OWTS rely on physical, chemical and biological soil processes to treat wastewater and these processes may be affected by climate change. We simulated the fate and transport of N in different types of OWTS drainfields, or soil treatment areas (STA) under current and changing climate scenarios, using 2D/3D HYDRUS software. Experimental data from a mesocosm-scale study, including soil moisture content, and total N, ammonium (NH4+) and nitrate (NO3-) concentrations, were used to calibrate the model. A water content-dependent function was used to compute the nitrification and denitrification rates. Three types of drainfields were simulated: (1) a pipe-and-stone (P&S), (2) advanced soil drainfields, pressurized shallow narrow drainfield (PSND) and (3) Geomat (GEO), a variation of SND. The model was calibrated with acceptable goodness-of-fit between the observed and measured values. Average root mean square error (RSME) ranged from 0.18 and 2.88 mg L-1 for NH4+ and 4.45 mg L-1 to 9.65 mg L-1 for NO3- in all drainfield types. The calibrated model was used to estimate N fluxes for both conventional and advanced STAs under current and changing climate conditions, i.e. increased soil temperature and higher water table. The model computed N losses from nitrification and denitrification differed little from measured losses in all STAs. The modeled N losses occurred mostly as NO3- in water outputs, accounting for more than 82% of N inputs in all drainfields. Losses as N2 were estimated to be 10.4% and 9.7% of total N input concentration for SND and Geo, respectively. The highest N2 losses, 17.6%, were estimated for P&S. Losses as N2 increased to 22%, 37% and 21% under changing climate conditions for Geo, PSND and P&S, respectively. These findings can provide practitioners

  2. Advanced practice registered nurses and physician assistants in sleep centers and clinics: a survey of current roles and educational background.

    Science.gov (United States)

    Colvin, Loretta; Cartwright, Ann; Collop, Nancy; Freedman, Neil; McLeod, Don; Weaver, Terri E; Rogers, Ann E

    2014-05-15

    To survey Advanced Practice Registered Nurse (APRN) and Physician Assistant (PA) utilization, roles and educational background within the field of sleep medicine. Electronic surveys distributed to American Academy of Sleep Medicine (AASM) member centers and APRNs and PAs working within sleep centers and clinics. Approximately 40% of responding AASM sleep centers reported utilizing APRNs or PAs in predominantly clinical roles. Of the APRNs and PAs surveyed, 95% reported responsibilities in sleep disordered breathing and more than 50% in insomnia and movement disorders. Most APRNs and PAs were prepared at the graduate level (89%), with sleep-specific education primarily through "on the job" training (86%). All APRNs surveyed were Nurse Practitioners (NPs), with approximately double the number of NPs compared to PAs. APRNs and PAs were reported in sleep centers at proportions similar to national estimates of NPs and PAs in physicians' offices. They report predominantly clinical roles, involving common sleep disorders. Given current predictions that the outpatient healthcare structure will change and the number of APRNs and PAs will increase, understanding the role and utilization of these professionals is necessary to plan for the future care of patients with sleep disorders. Surveyed APRNs and PAs reported a significant deficiency in formal and standardized sleep-specific education. Efforts to provide formal and standardized educational opportunities for APRNs and PAs that focus on their clinical roles within sleep centers could help fill a current educational gap.

  3. Incremental Innovation and Progress in Advanced Squamous Cell Lung Cancer: Current Status and Future Impact of Treatment.

    Science.gov (United States)

    Langer, Corey J; Obasaju, Coleman; Bunn, Paul; Bonomi, Philip; Gandara, David; Hirsch, Fred R; Kim, Edward S; Natale, Ronald B; Novello, Silvia; Paz-Ares, Luis; Pérol, Maurice; Reck, Martin; Ramalingam, Suresh S; Reynolds, Craig H; Socinski, Mark A; Spigel, David R; Wakelee, Heather; Mayo, Carlos; Thatcher, Nick

    2016-12-01

    Squamous cell lung cancer (sqCLC) is an aggressive form of cancer that poses many therapeutic challenges. Patients tend to be older, present at a later stage, and have a high incidence of comorbidities, which can compromise treatment delivery and exacerbate toxicity. In addition, certain agents routinely available for nonsquamous cell histologic subtypes, such as bevacizumab and pemetrexed, are contraindicated or lack efficacy in sqCLC. Therapeutic progress has been much slower for advanced sqCLC, with median survival times of approximately 9 to 11 months in most studies. Herein, we discuss the current therapeutic landscape for patients with sqCLC versus with nonsquamous NSCLC. Current evidence indicates that new targeted treatments, notably monoclonal antibodies such as ramucirumab and necitumumab, and immunotherapies such as nivolumab and pembrolizumab can provide survival prolongation, although the benefits are still relatively modest. These incremental improvements, all realized since 2012, in aggregate, will very likely have a clinically meaningful impact for patients with sqCLC. We also discuss recent genomic studies of sqCLC that have identified potentially actionable molecular targets, as well as the relevant targeted agents in clinical development. Finally, we discuss the magnitude of survival benefit and the risk-to-benefit ratio that would prove clinically meaningful in this underserved patient population with unmet needs. Copyright © 2016 International Association for the Study of Lung Cancer. Published by Elsevier Inc. All rights reserved.

  4. Proceedings of the Prop'Elec 2000 colloquium. Advances of electric drive in urban transportation systems; Actes du colloque Prop'Elec 2000. Progres de la traction electrique dans les transports urbains

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2000-07-01

    This document is the proceedings of Prop'Elec 2000 colloquium on the advances in electric power drive in urban transportation systems. The colloquium comprises 5 sessions dealing with: 1 - public collective electric-powered transportation system: synthesis of urban guided systems (C. Soulas, INRETS), the fast travelator (A. Cote, RATP), the power supply system of METEOR automatic underground railway (P. Lagrange, W. Seiler, RATP); 2 - electrical drive in urban transportation systems: start-up of a thermal engine with super-capacitors (D. Bouquain (CREEBEL), H. Gualous, A. Djerdir, A. Berthon, J.M. Kauffmann (L2ES, IGE)), The LEV (light weight electric vehicle) project in Mendrisio (U. Schwegler, LEV/Suisse), prototype of electrical bike that use a wheel-engine (C. Espanet, F. Gustin, J.M. Kauffmann (IGE), S. Robert, M. Karmous (EICN)), TWIL: a new generation of small electrical bikes (E. Escallot, T. Bontems (EPMI)), thermal and magnetic analysis of a rectilinear movement actuator (J.C. Vannier, M. Kadiri (SUPELEC)), torque undulation and vibrations in automobile electrical drives (A.L. Bui-Van (Renault), A. Fonseca (LEG)); 3 - collective electric-powered transportation systems: STARS: autonomous transportation system with flywheel charging at the station (P. Gibard (Alstom Transport), K. Abuda, J.M. Vinassa (IXL Bordeaux)), Translhor tramway: presentation of the drive system (L. Verdier, LHOR); 4 - electric-powered and hybrid vehicles: batteries for electric-powered vehicles (J.F. Fauvarque, CNAM), Li-ion batteries and their application in automotive industry (T. Faugeras, SAFT), optimized drive systems for electric-powered vehicles (J. Saint-Michel, Leroy Somer), the Citroen Xsara Dynactive (S. Derou, PSA), 5 - electric-powered and hybrid vehicles: the electrical car in tomorrows' city (M. Parent, INRIA), the market of electric-powered vehicles in France and Europe (M. Valet, PSA). (J.S.)

  5. Driving things

    DEFF Research Database (Denmark)

    Nevile, Maurice Richard

    2015-01-01

    . pp.155 ((http://www.infrastructure.gov.au/roads/safety/publications/2010/pdf/rsgr_2010001.pdf)) Nevile, M., Haddington, P., Heinemann, T., Rauniomaa, M. (Eds.) Interacting with objects: Language, materiality, and social activity. Amsterdam/Philadelphia: John Benjamins. Redshaw, S. (2008....... Interaction with objects reflects the car’s role beyond mere transport as a site of personal, social, and work life (Featherstone et al. 2005; Redshaw 2008). Studies of interaction examine this role as it is actually enacted, understood, and accomplished, in situ through participants’ practices (e.g. Laurier...... of in-car distractions, and how they impact driving activities (Nevile & Haddington 2010). Data are video recordings of ordinary journeys, capturing drivers and passengers in real-world real-time driving situations (27 hours, 90 journeys). For driving and road safety, research and experience has...

  6. Community Drive

    DEFF Research Database (Denmark)

    Magnussen, Rikke

    2018-01-01

    opportunity to break boundaries between research institutions and surrounding communities through the involvement of new types of actors, knowledge forms and institutions (OECD, 2011). This paper presents the project Community Drive a three year cross disciplinary community-driven game– and data-based project....... In the paper we present how the project Community Drive initiated in May 2018 is based on results from pilot projects conducted from 2014 – 2017. Overall these studies showed that it is a strong motivational factor for students to be given the task to change their living conditions through redesign...... of living in the area. The paper discusses potentials and pitfalls of designing community-driven science gaming environments and how results from previous studies can form the project Community Drive....

  7. Assessing the Driver’s Current Level of Working Memory Load with High Density Functional Near-infrared Spectroscopy: A Realistic Driving Simulator Study

    Directory of Open Access Journals (Sweden)

    Anirudh Unni

    2017-04-01

    Full Text Available Cognitive overload or underload results in a decrease in human performance which may result in fatal incidents while driving. We envision that driver assistive systems which adapt their functionality to the driver’s cognitive state could be a promising approach to reduce road accidents due to human errors. This research attempts to predict variations of cognitive working memory load levels in a natural driving scenario with multiple parallel tasks and to reveal predictive brain areas. We used a modified version of the n-back task to induce five different working memory load levels (from 0-back up to 4-back forcing the participants to continuously update, memorize, and recall the previous ‘n’ speed sequences and adjust their speed accordingly while they drove for approximately 60 min on a highway with concurrent traffic in a virtual reality driving simulator. We measured brain activation using multichannel whole head, high density functional near-infrared spectroscopy (fNIRS and predicted working memory load level from the fNIRS data by combining multivariate lasso regression and cross-validation. This allowed us to predict variations in working memory load in a continuous time-resolved manner with mean Pearson correlations between induced and predicted working memory load over 15 participants of 0.61 [standard error (SE 0.04] and a maximum of 0.8. Restricting the analysis to prefrontal sensors placed over the forehead reduced the mean correlation to 0.38 (SE 0.04, indicating additional information gained through whole head coverage. Moreover, working memory load predictions derived from peripheral heart rate parameters achieved much lower correlations (mean 0.21, SE 0.1. Importantly, whole head fNIRS sampling revealed increasing brain activation in bilateral inferior frontal and bilateral temporo-occipital brain areas with increasing working memory load levels suggesting that these areas are specifically involved in workload

  8. COMETS2: An advanced MATLAB toolbox for the numerical analysis of electric fields generated by transcranial direct current stimulation.

    Science.gov (United States)

    Lee, Chany; Jung, Young-Jin; Lee, Sang Jun; Im, Chang-Hwan

    2017-02-01

    Since there is no way to measure electric current generated by transcranial direct current stimulation (tDCS) inside the human head through in vivo experiments, numerical analysis based on the finite element method has been widely used to estimate the electric field inside the head. In 2013, we released a MATLAB toolbox named COMETS, which has been used by a number of groups and has helped researchers to gain insight into the electric field distribution during stimulation. The aim of this study was to develop an advanced MATLAB toolbox, named COMETS2, for the numerical analysis of the electric field generated by tDCS. COMETS2 can generate any sizes of rectangular pad electrodes on any positions on the scalp surface. To reduce the large computational burden when repeatedly testing multiple electrode locations and sizes, a new technique to decompose the global stiffness matrix was proposed. As examples of potential applications, we observed the effects of sizes and displacements of electrodes on the results of electric field analysis. The proposed mesh decomposition method significantly enhanced the overall computational efficiency. We implemented an automatic electrode modeler for the first time, and proposed a new technique to enhance the computational efficiency. In this paper, an efficient toolbox for tDCS analysis is introduced (freely available at http://www.cometstool.com). It is expected that COMETS2 will be a useful toolbox for researchers who want to benefit from the numerical analysis of electric fields generated by tDCS. Copyright © 2016. Published by Elsevier B.V.

  9. Dementia and Robotics: People with Advancing Dementia and Their Carers Driving an Exploration into an Engineering Solution to Maintaining Safe Exercise Regimes.

    Science.gov (United States)

    Cooper, Carol; Penders, Jacques; Procter, Paula M

    2016-01-01

    The merging of the human world and the information technology world is advancing at a pace, even for those with dementia there are many useful smart 'phone applications including reminders, family pictures display, GPS functions and video communications. This paper will report upon initial collaborative work developing a robotic solution to engaging individuals with advancing dementia in safe exercise regimes. The research team has been driven by the needs of people with advancing dementia and their carers through a focus group methodology, the format, discussions and outcomes of these groups will be reported. The plans for the next stage of the research will be outlined including the continuing collaboration with advancing dementia and their carers.

  10. The temporary and accumulated effects of transcranial direct current stimulation for the treatment of advanced Parkinson’s disease monkeys

    Science.gov (United States)

    Li, Hao; Lei, Xiaoguang; Yan, Ting; Li, Hongwei; Huang, Baihui; Li, Ling; Xu, Liqi; Liu, Li; Chen, Nanhui; Lü, Longbao; Ma, Yuanye; Xu, Lin; Li, Jiali; Wang, Zhengbo; Zhang, Baorong; Hu, Xintian

    2015-01-01

    Transcranial direct current stimulation (tDCS) is a useful noninvasive technique of cortical brain stimulation for the treatment of neurological disorders. Clinical research has demonstrated tDCS with anodal stimulation of primary motor cortex (M1) in Parkinson’s disease (PD) patients significantly improved their motor function. However, few studies have been focused on the optimization of parameters which contributed significantly to the treatment effects of tDCS and exploration of the underline neuronal mechanisms. Here, we used different stimulation parameters of anodal tDCS on M1 for the treatment of aged advanced PD monkeys induced with 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) administration, and then analyzed the temporary and accumulated effects of tDCS treatment. The results indicated anodal tDCS on M1 very significantly improved motor ability temporarily; importantly, the treatment effects of anodal tDCS on M1 were quantitatively correlated to the accumulated stimulation instead of the stimuli intensity or duration respectively. In addition, c-fos staining showed tDCS treatment effects activated the neurons both in M1 and substantia nigra (SN). Therefore, we propose that long time and continue anodal tDCS on M1 is a better strategy to improve the motor symptoms of PD than individual manipulation of stimuli intensity or duration. PMID:26220760

  11. Innate and adaptive immunity in the development of depression: An update on current knowledge and technological advances

    Science.gov (United States)

    Haapakoski, Rita; Ebmeier, Klaus P.; Alenius, Harri; Kivimäki, Mika

    2016-01-01

    The inflammation theory of depression, proposed over 20 years ago, was influenced by early studies on T cell responses and since then has been a stimulus for numerous research projects aimed at understanding the relationship between immune function and depression. Observational studies have shown that indicators of immunity, especially C reactive protein and proinflammatory cytokines, such as interleukin 6, are associated with an increased risk of depressive disorders, although the evidence from randomized trials remains limited and only few studies have assessed the interplay between innate and adaptive immunity in depression. In this paper, we review current knowledge on the interactions between central and peripheral innate and adaptive immune molecules and the potential role of immune-related activation of microglia, inflammasomes and indoleamine-2,3-dioxygenase in the development of depressive symptoms. We highlight how combining basic immune methods with more advanced ‘omics’ technologies would help us to make progress in unravelling the complex associations between altered immune function and depressive disorders, in the identification of depression-specific biomarkers and in developing immunotherapeutic treatment strategies that take individual variability into account. PMID:26631274

  12. Ambient light based interaction concept for an integrative driver assistance system – a driving simulator study

    OpenAIRE

    Dziennus, Marc; Kelsch, Johann; Schieben, Anna

    2015-01-01

    For today’s vehicles several advanced driver assistance systems are on the market supporting the driver in critical driving situations or automating parts of the driving tasks. In the future there will be even more. Currently, those assistance systems do not use a common and consistent interaction strategy to communicate with the driver. The goal of the present study is to present and to evaluate a concept using ambient light for presenting information of different assistance systems in an in...

  13. Electric vehicle drive systems

    Science.gov (United States)

    Appleyard, M.

    1992-01-01

    New legislation in the State of California requires that 2% of vehicles sold there from 1998 will be 'zero-emitting'. This provides a unique market opportunity for developers of electric vehicles but substantial improvements in the technology are probably required if it is to be successfully exploited. There are around a dozen types of battery that are potentially relevant to road vehicles but, at the present, lead/acid and sodium—sulphur come closest to combining acceptable performance, life and cost. To develop an efficient, lightweight electric motor system requires up-to-date techniques of magnetics design, and the latest power-electronic and microprocessor control methods. Brushless machines, coupled with solid-state inverters, offer the most economical solution for mass production, even though their development costs are higher than for direct-current commutator machines. Fitted to a small car, even the highest energy-density batteries will only provide around 200 km average range before recharging. Therefore, some form of supplementary on-board power generation will probably be needed to secure widespread acceptance by the driving public. Engine-driven generators of quite low power can achieve useful increases in urban range but will fail to qualify as 'zero-emitting'. On the other hand, if the same function could be economically performed by a small fuel-cell using hydrogen derived from a methanol reformer, then most of the flexibility provided by conventional vehicles would be retained. The market prospects for electric cars would then be greatly enhanced and their dependence on very advanced battery technology would be reduced.

  14. Method of speed sensorless direct field oriented control based on flux observer for current source inverter drive induction machine; Denryugata inverter kudo yudoki no niji jisoku observer ni motozuku sokudo sensorless chokusetsugata vector seigyo no ichihoshiki

    Energy Technology Data Exchange (ETDEWEB)

    Kasa, N.; Karino, T.; Watanabe, H. [Tokyo Metropolitan Institute of Technology, Tokyo (Japan)

    1995-12-20

    Many sensorless vector control systems have been proposed to increase the reliability and to reduce costs of the systems. However the parameters of an induction machine are changed by the temperature, the estimated speed may be incorrect value. When a constant torque drive system is constructed by a sensorless system and a current source inverter (CSI), the accuracy of the estimated speed influenced directly the response of the torque. In this paper, a direct field oriented control system is constructed by the flux observer which is low sensitivity to the rotor resistance variation and a proposed speed estimation scheme in a torque control system driven by a CSI. We compared experimental results by a voltage source inverter system and by the CSI system which is adopted our sensorless vector control scheme. At a lower speed condition, the system identifies the stator resistance, and we can estimate rotor speed correctly. Then the CSI system drives stably the induction machine without the speed sensor in a lower speed condition, and it can be applied to the constant torque drive systems. 7 refs., 17 figs., 1 tab.

  15. Neutral-point current modeling and control for Neutral-Point Clamped three-level converter drive with small DC-link capacitors

    DEFF Research Database (Denmark)

    Maheshwari, Ram Krishan; Munk-Nielsen, Stig; Busquets-Monge, Sergio

    2011-01-01

    A Neutral-Point-Clamped (NPC) three-level inverter with small DC-link capacitors is presented in this paper. This inverter requires zero average neutral-point current for stable neutral-point potential. A simple carrier based modulation strategy is proposed for achieving zero average neutral......-point current. A new simplified model of the neutral-point voltage dynamics is derived for the proposed modulation strategy. This model shows that the neutral-point current is proportional to the power drawn from the converter and it enables the use of well established classical control theory for neutral......-point voltage controller design. A PI controller is used for neutral-point voltage balance. The implementation of the proposed modulation strategy and controller is simple. It does not require any information about the output phase currents. The controller is implemented in a 7.5 kW induction machine based...

  16. CLIC Drive Beam Phase Stabilisation

    CERN Document Server

    Gerbershagen, Alexander; Schulte, Daniel

    The thesis presents phase stability studies for the Compact Linear Collider (CLIC) and focuses in particular on CLIC Drive Beam longitudinal phase stabilisation. This topic constitutes one of the main feasibility challenges for CLIC construction and is an essential component of the current CLIC stabilisation campaign. The studies are divided into two large interrelated sections: the simulation studies for the CLIC Drive Beam stability, and measurements, data analysis and simulations of the CLIC Test Facility (CTF3) Drive Beam phase errors. A dedicated software tool has been developed for a step-by-step analysis of the error propagation through the CLIC Drive Beam. It uses realistic RF potential and beam loading amplitude functions for the Drive and Main Beam accelerating structures, complete models of the recombination scheme and compressor chicane as well as of further CLIC Drive Beam modules. The tool has been tested extensively and its functionality has been verified. The phase error propagation at CLIC h...

  17. A gate drive circuit for gate-turn-off (GTO) devices in series stack

    International Nuclear Information System (INIS)

    Despe, O.

    1999-01-01

    A gate-turn-off (GTO) switch is under development at the Advanced Photon Source as a replacement for a thyratron switch in high power pulsed application. The high voltage in the application requires multiple GTOs connected in series. One component that is critical to the success of GTO operation is the gate drive circuit. The gate drive circuit has to provide fast high-current pulses to the GTO gate for fast turn-on and turn-off. It also has to be able to operate while floating at high voltage. This paper describes a gate drive circuit that meets these requirements

  18. Current pain education within undergraduate medical studies across Europe: Advancing the Provision of Pain Education and Learning (APPEAL) study

    Science.gov (United States)

    Briggs, Emma V; Battelli, Daniele; Gordon, David; Kopf, Andreas; Ribeiro, Sofia; Puig, Margarita M; Kress, Hans G

    2015-01-01

    Objectives Unrelieved pain is a substantial public health concern necessitating improvements in medical education. The Advancing the Provision of Pain Education and Learning (APPEAL) study aimed to determine current levels and methods of undergraduate pain medicine education in Europe. Design and methods Using a cross-sectional design, publicly available curriculum information was sought from all medical schools in 15 representative European countries in 2012–2013. Descriptive analyses were performed on: the provision of pain teaching in dedicated pain modules, other modules or within the broader curriculum; whether pain teaching was compulsory or elective; the number of hours/credits spent teaching pain; pain topics; and teaching and assessment methods. Results Curriculum elements were publicly available from 242 of 249 identified schools (97%). In 55% (133/242) of schools, pain was taught only within compulsory non-pain-specific modules. The next most common approaches were for pain teaching to be provided wholly or in part via a dedicated pain module (74/242; 31%) or via a vertical or integrated approach to teaching through the broader curriculum, rather than within any specific module (17/242; 7%). The curricula of 17/242 schools (7%) showed no evidence of any pain teaching. Dedicated pain modules were most common in France (27/31 schools; 87%). Excluding France, only 22% (47/211 schools) provided a dedicated pain module and in only 9% (18/211) was this compulsory. Overall, the median number of hours spent teaching pain was 12.0 (range 4–56.0 h; IQR: 12.0) for compulsory dedicated pain modules and 9.0 (range 1.0–60.0 h; IQR: 10.5) for other compulsory (non-pain specific) modules. Pain medicine was principally taught in classrooms and assessed by conventional examinations. There was substantial international variation throughout. Conclusions Documented pain teaching in many European medical schools falls far short of what might be expected given the

  19. Daylighting as the Driving Force of the Design Process: from the Results of a Survey to the Implementation into an Advanced Daylighting Project

    Directory of Open Access Journals (Sweden)

    Valerio R.M. Lo Verso

    2014-12-01

    Full Text Available This paper presents a study for the transformation of an industrial area in Turin, Italy. The area hosts two buildings (one of which appointed as listed to be transformed into dwellings. A synergic approach was adopted which combined expertise from architecture, social-economics, psychology and building physics sciences. Building physics sciences lead the research team. A user-centered design was pursued, using a bottom-up approach. A specifically developed questionnaire was submitted on-line to potential users. The survey showed that ‘amount of daylight’, ‘size of rooms’, ‘tranquility of the area’ and ‘presence of a private garden’ were perceived by users to be the most positive aspects of both their present and future, ideal home. These results were then implemented into the project. The exploitation of daylight became the driving force of the transformation project. Especially for the listed building, skylights and light wells were designed to bring daylight into the cores of the buildings, which host common spaces such as libraries or study rooms. The amount of daylight was assessed through the legislative index of the average daylight factor and through a climate-based modeling approach, calculating dynamic metrics such as the spatial daylight autonomy and the Useful Daylight Illuminance. The paper critically compares and discusses these two approaches. Finally, the energy demand for lighting was also calculated to analyze how the increased exploitation of daylight may imply a reduced need for electricity for lighting.

  20. Robust Adaptive Speed Control of Induction Motor Drives

    DEFF Research Database (Denmark)

    Bidstrup, N.

    This thesis concerns speed control of current vector controlled induction motor drives (CVC drives). The CVC drive is an existing prototype drive developed by Danfoss A/S, Transmission Division. Practical tests have revealed that the open loop dynamical properties of the CVC drive are highly...