WorldWideScience

Sample records for adults current standards

  1. Inexpensive Eddy-Current Standard

    Science.gov (United States)

    Berry, Robert F., Jr.

    1985-01-01

    Radial crack replicas serve as evaluation standards. Technique entails intimately joining two pieces of appropriate aluminum alloy stock and centering drilled hole through and along interface. Bore surface of hole presents two vertical stock interface lines 180 degrees apart. These lines serve as radial crack defect replicas during eddy-current technique setup and verification.

  2. Standards for Adult Education ESL Programs

    Science.gov (United States)

    TESOL Press, 2013

    2013-01-01

    What are the components of a quality education ESL program? TESOL's "Standards for Adult Education ESL Programs" answers this question by defining quality components from a national perspective. Using program indicators in eight distinct areas, the standards can be used to review an existing program or as a guide in setting up a new…

  3. Nuclear standards: current issues and future trends

    International Nuclear Information System (INIS)

    A summary of the important issues that currently face the nuclear standards field is presented and a discussion of how each of these issues is being resolved is given. The economic benefits that properly developed standards produce are listed

  4. A review of the quantum current standard

    International Nuclear Information System (INIS)

    The electric current, voltage, and resistance standards are the most important standards related to electricity and magnetism. Of these three standards, only the ampere, which is the unit of electric current, is an International System of Units (SI) base unit. However, even with modern technology, relatively large uncertainty exists regarding the generation and measurement of current. As a result of various innovative techniques based on nanotechnology and novel materials, new types of junctions for quantum current generation and single-electron current sources have recently been proposed. These newly developed methods are also being used to investigate the consistency of the three quantum electrical effects, i.e. the Josephson, quantum Hall, and single-electron tunneling effects, which are also known as ‘the quantum metrology triangle’. This article describes recent research and related developments regarding current standards and quantum-metrology-triangle experiments. (topical review)

  5. A review of the quantum current standard

    Science.gov (United States)

    Kaneko, Nobu-Hisa; Nakamura, Shuji; Okazaki, Yuma

    2016-03-01

    The electric current, voltage, and resistance standards are the most important standards related to electricity and magnetism. Of these three standards, only the ampere, which is the unit of electric current, is an International System of Units (SI) base unit. However, even with modern technology, relatively large uncertainty exists regarding the generation and measurement of current. As a result of various innovative techniques based on nanotechnology and novel materials, new types of junctions for quantum current generation and single-electron current sources have recently been proposed. These newly developed methods are also being used to investigate the consistency of the three quantum electrical effects, i.e. the Josephson, quantum Hall, and single-electron tunneling effects, which are also known as ‘the quantum metrology triangle’. This article describes recent research and related developments regarding current standards and quantum-metrology-triangle experiments.

  6. Current and future neutron radiography standards

    International Nuclear Information System (INIS)

    Only two organizations are actively producing standards which are used in neutron radiology (NR): the American Society of Testing and Materials (ASTM) and the International Organization for Standardization (ISO). Six ASTM standards exist that address the neutron radiography method. Two of the ASTM standards have been extensively used world-wide. ISO has a working group which is developing three standards that also address the neutron radiography method. Two of these are currently making their way through the ISO approval system. No ASTM or ISO standards exist for the neutron radioscopic method. Future ASTM standards will address the neutron radioscopic method and neutron radiologic system characterization. It is expected that similar efforts will be undertaken in ISO. Given the relatively small community providing neutron radiologic services, international cooperation and the need for ISO standards will most likely continue to grow.(author)

  7. Current work on dosimetry standards in Japan

    International Nuclear Information System (INIS)

    Basic concepts on standardization of radiation dosimetry are reviewed. The present situation regarding primary standards in the Electrotechnical Laboratory, the primary standard dosimetry laboratory in Japan, is presented, considering the following; (i) Established dosimetric standards of exposure for soft and medium-energy X-rays and gamma rays. This section includes methods of their standardization, and discusses accuracies of instruments operating as environmental-level, protection-level, inspection-level, therapy-level, and processing-level measuring systems. The results of international comparisons between ETL and other, foreign primary standard dosimetry laboratories are presented; (ii) Other established radiation standards related to derivation of radiation absorbed dose. These primary standards include those for the neutron emission rates, thermal and fast neutron flux densities, energy fluences for high-energy photons and electrons, and activities of several kinds of radioactive material. The accuracies and results of international comparisons relating to them are also presented; (iii) Research being carried out at ETL. The current status of the dissemination of radiation standards is presented considering in particular: (i) The calibration services available at ETL, the categories of these services, energy and dose rate ranges, methods, accuracies, etc.; (ii) The calibration services available in certain other organizations considered as SSDLs in Japan, the categories of such work, methods, accuracies etc.; (iii) Present endeavours towards establishing a systematic and effective dissemination system (a so-called Traceability System) in Japan

  8. Adult Cigarette Smoking in the United States: Current Estimates

    Science.gov (United States)

    ... Health More CDC Sites Current Cigarette Smoking Among Adults in the United States Recommend on Facebook Tweet ... every day or some days. Current Smoking Among Adults in 2014 (Nation) By Gender 1 Men are ...

  9. Development of BMD-1 model standard pulse current generator

    International Nuclear Information System (INIS)

    The BMD-1 Model Standard Pulse Current Generator is a pulse current calibration instrument. It is used to calibrate current probe, amplifier of current probe and other current measurement instruments. The standard pulse current generator uses a perfect current switch to transfer the standard direct current into the standard pulse current. It provides a variable output current ranges from 1 mA to 1 A, current accuracy is +-(0.25% + 2μA). The standard pulse generator provides three work modes of output current: DC, signal pulse and variable frequencies from 10 Hz to 1 MHz, and provides a variable pulse current widths from 0.5 to 50 μs

  10. The Current Brouhaha about Standards in England

    Science.gov (United States)

    Brown, Roger

    2010-01-01

    Following a report by a Parliamentary Committee, the Higher Education Funding Council for England is consulting the sector about a strengthened national quality assurance system, with an enhanced role for information about quality and a closer focus on academic standards. This article provides a critical review of the main proposals.

  11. Current standard treatment for pediatric glioma patients

    International Nuclear Information System (INIS)

    In this paper, we selected three representative disorders among pediatric gliomas and reviewed standard treatments for these diseases. The formation of this rare disease is involved with BRAF mutation as well as cerebellar pilocytic astrocytoma. Radical resection is not recommended as initial therapy due to high morbidity. Despite its good tumor control, radiotherapy is not a standard therapy due to neuroendocrine and neurocognitive dysfunction. Several papers have reported the effectiveness of platinum-based chemotherapy, which is a useful for induction therapy. Recent progress in molecular analyses has suggested that some markers might be used for staging ependymoma. While total resection is considered to be strongly correlated with patients' survival, the majority of recurrence occurs in the primary site. Despite many clinical trials, chemotherapeutic agents were not found to be effective for this disease. Since whole brain radiation cannot prevent dissemination, local radiation is recommended for adjuvant therapy. The prognosis of this disease is still dismal, and median survival time is within 1 year. Although clinical trials have been conducted to assess the efficacy of chemotherapy prior to, concomitantly with, or after radiotherapy, an effective regimen has not yet been established. Therefore, only conventional local radiotherapy is the standard regimen for this disease. A new therapeutic approach, such as convection-enhanced drug delivery, would be required for improved outcomes in patients with this disease. (author)

  12. Current Cigarette Use Among Adults (BRFSS) PDF Slides

    Data.gov (United States)

    U.S. Department of Health & Human Services — Download the current cigarette use among adults slides. These slides are available in PDF and PowerPoint formats. The PowerPoint version can be found at:...

  13. Mitogenome metadata: current trends and proposed standards.

    Science.gov (United States)

    Strohm, Jeff H T; Gwiazdowski, Rodger A; Hanner, Robert

    2016-09-01

    Mitogenome metadata are descriptive terms about the sequence, and its specimen description that allow both to be digitally discoverable and interoperable. Here, we review a sampling of mitogenome metadata published in the journal Mitochondrial DNA between 2005 and 2014. Specifically, we have focused on a subset of metadata fields that are available for GenBank records, and specified by the Genomics Standards Consortium (GSC) and other biodiversity metadata standards; and we assessed their presence across three main categories: collection, biological and taxonomic information. To do this we reviewed 146 mitogenome manuscripts, and their associated GenBank records, and scored them for 13 metadata fields. We also explored the potential for mitogenome misidentification using their sequence diversity, and taxonomic metadata on the Barcode of Life Datasystems (BOLD). For this, we focused on all Lepidoptera and Perciformes mitogenomes included in the review, along with additional mitogenome sequence data mined from Genbank. Overall, we found that none of 146 mitogenome projects provided all the metadata we looked for; and only 17 projects provided at least one category of metadata across the three main categories. Comparisons using mtDNA sequences from BOLD, suggest that some mitogenomes may be misidentified. Lastly, we appreciate the research potential of mitogenomes announced through this journal; and we conclude with a suggestion of 13 metadata fields, available on GenBank, that if provided in a mitogenomes's GenBank record, would increase their research value. PMID:25693692

  14. Standard guidelines for electrosurgery with radiofrequency current

    OpenAIRE

    Mutalik Sharad

    2009-01-01

    Definition: Radiofrequency (RF) induces thermal destruction of the targeted tissue by an electrical current at a frequency of 0.5 MHz (RF). As the electrode tip is not heated, there is minimal thermal damage to the surrounding tissues, producing good esthetic results. Therefore, RF ablation is also known as cold ablation or "coblation." Modality: It has three modes of operation: (a) Cut, (b) cut and coagulate and (c) coagulate. Therefore, it can be used for various purposes like incision, ...

  15. Standard guidelines for electrosurgery with radiofrequency current

    Directory of Open Access Journals (Sweden)

    Mutalik Sharad

    2009-08-01

    Full Text Available Definition: Radiofrequency (RF induces thermal destruction of the targeted tissue by an electrical current at a frequency of 0.5 MHz (RF. As the electrode tip is not heated, there is minimal thermal damage to the surrounding tissues, producing good esthetic results. Therefore, RF ablation is also known as cold ablation or "coblation." Modality: It has three modes of operation: (a Cut, (b cut and coagulate and (c coagulate. Therefore, it can be used for various purposes like incision, ablation, fulguration, shave excision and coagulation. Because of the coagulation facility, hemostasis can be achieved and operation becomes easier and faster. Indications: It is effective in treating various skin conditions like dermatosis papulosa nigra, warts, molluscum contagiosum, colloid milia, acquired junctional, compound and dermal melanocytic nevi, seborrheic keratosis, skin tags, granuloma pyogenicum, verrucous epidermal nevi, xanthelesma, rhinophyma, superficial basal cell carcinoma and telangiectasia. It can also be used for cosmetic indications such as resurfacing, earlobe repair and blepharoplasty. Anesthesia: The procedure is accomplished either under topical anesthesia eutactic mixture of local anesthetics or local injectable anesthesia, under all aseptic precautions. Procedure: While operating, only the tip of the electrode should come in contact with the tissue. Actual contact of the electrode with the tissue should be very brief in order to prevent excessive damage to the deeper tissues. This can be accomplished by moving the electrode quickly. Complications: Complications are uncommon and mainly occur due to an improper technique. The treating physician should be aware of the contraindications of the procedure as listed in these guidelines. Physician qualification: RF surgery may be performed by a dermatologist who has acquired adequate training during post-graduation or through recognized fellowships and workshops dedicated to RF surgery. He

  16. Adult Current Smoking: Differences in Definitions and Prevalence Estimates—NHIS and NSDUH, 2008

    Directory of Open Access Journals (Sweden)

    Heather Ryan

    2012-01-01

    Full Text Available Objectives. To compare prevalence estimates and assess issues related to the measurement of adult cigarette smoking in the National Health Interview Survey (NHIS and the National Survey on Drug Use and Health (NSDUH. Methods. 2008 data on current cigarette smoking and current daily cigarette smoking among adults ≥18 years were compared. The standard NHIS current smoking definition, which screens for lifetime smoking ≥100 cigarettes, was used. For NSDUH, both the standard current smoking definition, which does not screen, and a modified definition applying the NHIS current smoking definition (i.e., with screen were used. Results. NSDUH consistently yielded higher current cigarette smoking estimates than NHIS and lower daily smoking estimates. However, with use of the modified NSDUH current smoking definition, a notable number of subpopulation estimates became comparable between surveys. Younger adults and racial/ethnic minorities were most impacted by the lifetime smoking screen, with Hispanics being the most sensitive to differences in smoking variable definitions among all subgroups. Conclusions. Differences in current cigarette smoking definitions appear to have a greater impact on smoking estimates in some sub-populations than others. Survey mode differences may also limit intersurvey comparisons and trend analyses. Investigators are cautioned to use data most appropriate for their specific research questions.

  17. Radiation doses in adults and children in standardized diagnostic radiology

    International Nuclear Information System (INIS)

    For comparison of radiation exposure and risk in different diagnostic procedures for adults and children dose measurements and calculations of organs with special risk were carried out. Parameters of image formation influencing image quality as well as of exposure concerning infants and children are recorded and discussed as to radiation exposure and protection. Conclusions are drawn with respect to systems of image formation and to standards of examination and quality assurance

  18. Current lifestyle of young adults treated for cancer in childhood.

    OpenAIRE

    Evans, S E; Radford, M

    1995-01-01

    The aim of this study was to look at the current lifestyle of young adult survivors of childhood cancer between the ages of 16 and 30 years to document their achievements and expose any psychosocial problems. Sixty six young adult survivors were contacted and asked if they and their siblings (16-30 years) would take part in a lifestyle study; 48 patients and 38 sibling controls were interviewed. This took the form of a structured lifestyle questionnaire, a self esteem questionnaire (Oxford Ps...

  19. Latent autoimmune diabetes of the adult: current knowledge and uncertainty

    Science.gov (United States)

    Laugesen, E; Østergaard, J A; Leslie, R D G

    2015-01-01

    Patients with adult-onset autoimmune diabetes have less Human Leucocyte Antigen (HLA)-associated genetic risk and fewer diabetes-associated autoantibodies compared with patients with childhood-onset Type 1 diabetes. Metabolic changes at diagnosis reflect a broad clinical phenotype ranging from diabetic ketoacidosis to mild non-insulin-requiring diabetes, also known as latent autoimmune diabetes of the adult (LADA). This latter phenotype is the most prevalent form of adult-onset autoimmune diabetes and probably the most prevalent form of autoimmune diabetes in general. Although LADA is associated with the same genetic and immunological features as childhood-onset Type 1 diabetes, it also shares some genetic features with Type 2 diabetes, which raises the question of genetic heterogeneity predisposing to this form of the disease. The potential value of screening patients with adult-onset diabetes for diabetes-associated autoantibodies to identify those with LADA is emphasized by their lack of clinically distinct features, their different natural history compared with Type 2 diabetes and their potential need for a dedicated management strategy. The fact that, in some studies, patients with LADA show worse glucose control than patients with Type 2 diabetes, highlights the need for further therapeutic studies. Challenges regarding classification, epidemiology, genetics, metabolism, immunology, clinical presentation and treatment of LADA were discussed at a 2014 workshop arranged by the Danish Diabetes Academy. The presentations and discussions are summarized in this review, which sets out the current ideas and controversies surrounding this form of diabetes. What’s new? Latent autoimmune diabetes of the adult (LADA) is an autoimmune diabetes defined by adult-onset, presence of diabetes associated autoantibodies, and no insulin treatment requirement for a period after diagnosis. Immunologically, glutamic acid decarboxylase 65 autoantibodies are by far the most

  20. Current Concepts: Laser Treatment of Adult Vascular Lesions

    OpenAIRE

    Wall, Tomi L.

    2007-01-01

    Patients frequently seek treatment of cutaneous vascular lesions for both medical and cosmetic reasons. Advances in the use of lasers and light sources enable physicians to effectively treat vascular lesions that were previously untreatable. Given the plethora of devices available, selecting the appropriate laser system and treatment parameters can be confusing for the laser surgeon. This article reviews current concepts in the treatment of adult vascular conditions. It highlights the differe...

  1. Current issues of nuclear equipment standardization in Romania

    International Nuclear Information System (INIS)

    Standardization enhances: international cooperation; development of new nuclear techniques and technologies; characterization and checking procedures of equipment; sharing a common terminology. A historical sketch is given focussing: inception of standardization in electro-techniques at international scale; organization of the International Electrotechnical Commission, IEC; - current aspects of nuclear equipment standardization; activity of seven working groups devoted to nuclear reactor equipment; activity of seven groups working on radioprotection equipment; activity of four groups working on nuclear equipment. ISO organization and present issues concerning the nuclear technology development in Romania. It is presented the activity in the frame of CENELEC, CLC/TC45, for endorsing the IEC/TC45B standards. In 2007 a CENELEC/ BTT 127-1 working commission was formed to enhance assimilation of IEC /TC45 A standards in EU concerning the instrumentation and testing equipment in nuclear facilities. A questionnaire addressed to national committees was launched for endorsing the IEC TC45 A as EU standards. The presentation is completed with a review of Romanian activity in developing and adapting the Romanian nuclear standards to fulfill the requirements of nuclear technology market, the social requirements concerning the radioprotection and legislation requirements, as well

  2. Current lifestyle of young adults treated for cancer in childhood.

    Science.gov (United States)

    Evans, S E; Radford, M

    1995-05-01

    The aim of this study was to look at the current lifestyle of young adult survivors of childhood cancer between the ages of 16 and 30 years to document their achievements and expose any psychosocial problems. Sixty six young adult survivors were contacted and asked if they and their siblings (16-30 years) would take part in a lifestyle study; 48 patients and 38 sibling controls were interviewed. This took the form of a structured lifestyle questionnaire, a self esteem questionnaire (Oxford Psychologists Press), and an unstructured interview. Fifty five per cent of patients achieved five or more A-C grades at 'O' level/GCSE compared with 62% of siblings and a national average of 30%. Despite that these patients were significantly less likely to go on to higher education than their siblings. The two groups were equally employable and earning similar salaries. There were three cases of known employer prejudice. A slightly higher percentage of patients than siblings had their driving licence. Seventeen patients felt their appearance had changed and eight felt that they had a residual physical mobility problem. Both groups were socially active and equally likely to partake in competitive sports. There was no overall difference in the self esteem of the two groups. In general the survivors of childhood cancer were coping well in their young adult life and achieving the same lifestyle goals as their siblings. However, significant problems have been identified. PMID:7618909

  3. Epidemiological bases for the current ambient carbon monoxide standards.

    OpenAIRE

    Kuller, L H; Radford, E P

    1983-01-01

    Carbon monoxide is widely distributed in the environment, and acute or chronic toxic effects may be of considerable public health significance. A review of the basis for current ambient standards is given. Mortality and morbidity studies have been negative or equivocal in relating carbon monoxide levels to health effects, but studies in human subjects with compromised coronary or peripheral circulation support an effect of acute exposure to CO at blood levels equivalent to about 20 ppm over s...

  4. Nuclear aspects of neutral current non-standard $\

    CERN Document Server

    Papoulias, D K

    2013-01-01

    The nuclear aspects of flavour changing neutral current (FCNC) processes, predicted by various new-physics models to occur in the presence of nuclei, are examined by computing the relevant nuclear matrix elements within the context of the quasi-particle RPA using realistic strong two-body forces. One of our aims is to explore the role of the non-standard interactions (NSI) in the leptonic sector and specifically: (i) in lepton flavour violating (LFV) processes involving the neutral particles $\

  5. Treatment of adult ADHD: Is current knowledge useful to clinicians?

    Directory of Open Access Journals (Sweden)

    Terje Torgersen

    2008-03-01

    Full Text Available Terje Torgersen1,2, Bjørn Gjervan1,3, Kirsten Rasmussen31Department of Psychiatry, Sykehuset Levanger, Helse Nord-Troendelag HF, Levanger, Norway; 2Faculty of Medicine and 3Department of Psychology, Norwegian University of Science and Technology, Trondheim, NorwayAbstract: Psychostimulant drugs have for decades been considered the cornerstone of ADHD treatment. Non-stimulant drugs have also been reported successful. However, many controlled studies exclude patients with comorbidities typical for patients seen in clinical setting. Many patients are also considered non-responders to medication. Current knowledge might not be directly useful to clinicians. The present article reviews the literature on pharmacological and psychotherapeutic treatment in adult ADHD emphasizing comorbidity and other clinically important factors, as well as ADHD specific outcomes. Thirty-three relevant studies of pharmacotherapy and three studies of psychotherapy were included. Most subjects had little current comorbidity, but some studies included subjects with substance use disorder. Significant effect of treatment on ADHD symptoms was found in most studies using pharmacotherapy and all studies of psychotherapy. Both positive and negative effects on comorbid anxiety and depression measures were reported. Pharmacotherapy did not seem to have effect on substance use disorder. Few pharmacotherapy studies conducted any long-term follow-up; two studies that did, found that most subjects had discontinued medication. A clear-cut dose-respons relationship was not substanciated. In conclusion, clinicians have good support for both pharmacological and psychotherapeutic treatment of ADHD in adults, but should take additional measures to deal with comorbidities as well as treatment adherence.Keywords: ADHD, adults, treatment, stimulants, psychotherapy, comorbidity

  6. Evaluation of standard liver volume formulae for Chinese adults

    Institute of Scientific and Technical Information of China (English)

    Zheng-Rong Shi; Lu-Nan Yan; Bo Li; Tian-Fu Wen

    2009-01-01

    AIM:To evaluate different standard liver volume (SLV) formula and verify the applicability of the formulae for Chinese adults.METHODS:Data from 70 cases of living donor liver transplantation (LDLT) performed at our transplantation centers between January 2008 and April 2009 were analyzed.SLV was estimated using our recently reported formula [the Chengdu formula:SLV (mL) = 11.5×body weight (kg) + 334] and other reported formulae used for Chinese adults.Actual intraoperative liver volumes were obtained from a review of the patients' medical records.RESULTS:The actual right liver volume was not signifi-cantly different from the estimated right liver volume determined by the Chengdu formula,but was significantly smaller than estimates using the Heinemann,Urata,Vauthey,and Lee formulae (P<0.01),and significantly larger than estimates using the Fan formula (P<0.05).CONCLUSION:The Chengdu formula was demonstrated to be reliable by its application in LDLT.

  7. Current standard treatment of adult acute promyelocytic leukaemia.

    Science.gov (United States)

    Lo-Coco, Francesco; Cicconi, Laura; Breccia, Massimo

    2016-03-01

    The outcome of patients with acute promyelocytic leukaemia (APL) has dramatically improved over the last two decades, due to the introduction of combined all-trans retinoic acid (ATRA) and chemotherapy regimens and, more recently, to the advent of arsenic trioxide (ATO). ATRA and anthracycline-based chemotherapy remains a widely used strategy, providing cure rates above 80%, but it is associated with risk of severe infections and occurrence of secondary leukaemias. ATO is the most effective single agent in APL and, used alone or in combination with ATRA or ATRA and reduced-intensity chemotherapy, results in greater efficacy with considerably less haematological toxicity. The toxic profile of ATO includes frequent, but manageable, QTc prolongation and increase of liver enzymes. Two large randomized studies have shown that ATRA + ATO is superior to ATRA + chemotherapy for newly diagnosed low-risk APL resulting in 2-4 year event-free survival rates above 90% and very few relapses. According to real world data, the spectacular progress in APL outcomes reported in clinical trials has not been paralleled by a significant improvement in early death rates, this remains the most challenging issue for the final cure of the disease. PMID:26687281

  8. Adult-onset Still's disease: current challenges and future prospects

    Directory of Open Access Journals (Sweden)

    Siddiqui M

    2016-03-01

    Full Text Available Mariam Siddiqui,1 Michael S Putman,2 Anisha B Dua,11Department of Rheumatology, 2Department of Internal Medicine, The University of Chicago Medical Center, Chicago, IL, USA Abstract: Adult-onset Still's disease (AOSD – a multi-systemic inflammatory condition characterized by high fevers, polyarthritis, an evanescent rash, and pharyngitis – has been a challenging condition to diagnose expediently and treat effectively. Questions remain regarding the underlying pathophysiology and etiology of AOSD. Pathognomonic diagnostic tests and reliable biomarkers remain undiscovered. Over the past decade, important progress has been made. Diagnostic criteria employing glycosylated ferritin have improved specificity. More important, novel biologic therapies have offered important clues to AOSD's underlying pathophysiology. Cytokine-specific biologic therapies have been instrumental in providing more effective treatment for disease refractory to conventional treatment. While IL-1 therapy has demonstrated efficacy in refractory disease, novel therapies targeting IL-6 and IL-18 show great promise and are currently under investigation. Keywords: adult-onset Still's disease, biomarkers, therapeutics

  9. UV dose-effect relationships and current protection exposure standards

    International Nuclear Information System (INIS)

    In this paper we have attempted to quantify the health effects in man of uv-radiation exposure of wavelengths from 240 nm to 320 nm. Exposure to uv in this region could result in the formation of skin cancer or premature aging in man. The induction of cancer by uv radiation results from changes in genetic material. We have used the DNA action spectrum coupled with the uv skin cancer data available in the literature to derive the dose-effect relationships. The results are compared against the current uv protection standards

  10. Recent developments and current status of air kerma standards

    International Nuclear Information System (INIS)

    Primary Standard Dosimetry Laboratories (PSDL) usually maintain air kerma standards for kilovoltage x-rays (10 kV to 300 kV) and for 137Cs- and 60Co-γ radiation. Free-air ionisation chambers (FAC) and cavity ionisation chambers are used as primary air kerma standards for kilovoltage x-rays and for 137Cs- and 60Co-γ radiation, respectively. The majority of the National Metrology Institutes (NMIs) signed the Mutual Recognition Arrangement (MRA) of national measurement standards and of calibration and measurement certificates issued by NMIs. The MRA has been available for signature since 14th October 1999. According to the MRA, the signatories participate in CIPM key comparisons executed by the Consultative Committees or the BIPM, leading to a key comparison reference value. The degree of equivalence of a national measurement standard is expressed quantitatively in terms of its deviation from the key comparison reference value and the uncertainty of this deviation. For air kerma standards the Consultative Committee for Ionising Radiation (CCRI(I)) currently maintains three types of key comparisons and a so-called supplementary comparison. The air kerma key comparisons are organised bilaterally and are carried out between the air kerma standards of the BIPM and the participating NMIs. The radiations used are low-energy (10 kV to 50 kV) and medium energy (100 kV to 250 kV) x-ray beams and 137Cs- and 60Co-γ radiation. To be entitled to enter the key comparison database with respect to air kerma an NMI has to participate in a key comparison within a time period of 10 years. In keeping with the longstanding method of presenting the data, the CCRI(I) took the decision at its meeting in 1999 to use the BIPM determination of air kerma rate as the key comparison reference value. For this reason the BIPM air kerma standards are of special importance. Due to the fact that the air kerma key comparisons have been conducted on an ongoing basis since 1966 for low-energy x

  11. Beyond standard model physics at current and future colliders

    Science.gov (United States)

    Liu, Zhen

    The Large Hadron Collider (LHC), a multinational experiment which began running in 2009, is highly expected to discover new physics that will help us understand the nature of the universe and begin to find solutions to many of the unsolved puzzles of particle physics. For over 40 years the Standard Model has been the accepted theory of elementary particle physics, except for one unconfirmed component, the Higgs boson. The experiments at the LHC have recently discovered this Standard-Model-like Higgs boson. This discovery is one of the most exciting achievements in elementary particle physics. Yet, a profound question remains: Is this rather light, weakly-coupled boson nothing but a Standard Model Higgs or a first manifestation of a deeper theory? Also, the recent discoveries of neutrino mass and mixing, experimental evidences of dark matter and dark energy, matter-antimatter asymmetry, indicate that our understanding of fundamental physics is currently incomplete. For the next decade and more, the LHC and future colliders will be at the cutting-edge of particle physics discoveries and will shed light on many of these unanswered questions. There are many promising beyond-Standard-Model theories that may help solve the central puzzles of particle physics. To fill the gaps in our knowledge, we need to know how these theories will manifest themselves in controlled experiments, such as high energy colliders. I discuss how we can probe fundamental physics at current and future colliders directly through searches for new phenomena such as resonances, rare Higgs decays, exotic displaced signatures, and indirectly through precision measurements on Higgs in this work. I explore beyond standard model physics effects from different perspectives, including explicit models such as supersymmetry, generic models in terms of resonances, as well as effective field theory approach in terms of higher dimensional operators. This work provides a generic and broad overview of the physics

  12. Document of standardization of enteral nutrition access in adults

    Directory of Open Access Journals (Sweden)

    Lorena Arribas

    2014-07-01

    Full Text Available The group of standardization and protocols of the Spanish Society of Parenteral and Enteral Nutrition (SENPE published in 2011 a consensus document SENPE/SEGHNP/ANECIPN/SECP on enteral access for paediatric nutritional support. Along the lines of this document, we have developed another document on adult patients to homogenize the clinical practice and improve the quality of care in enteral access in this age group. The working group included health professionals (nurses, dietitians and doctor with extensive experience in enteral nutrition and access. We tried to find scientific evidence through a literature review and we used the criteria of the Agency for Health-care Research and Quality (AHRQ to classify the evidence (Grade of Recommendation A, B or C. Later the document was reviewed by external experts to the group and requested the endorsement of the Scientific and Educational Committee (CCE and the group of home artificial nutrition (NADYA of the SENPE. The full text will be published as a monograph number in this journal.

  13. Validation of the ultrastable low-noise current amplifier as travelling standard for small direct currents

    CERN Document Server

    Drung, Dietmar; Giblin, Stephen P; Djordjevic, Sophie; Piquemal, Francois; Séron, Olivier; Rengnez, Florentin; Götz, Martin; Pesel, Eckart; Scherer, Hansjörg

    2015-01-01

    An interlaboratory comparison of small-current generation and measurement capability is presented with the ultrastable low-noise current amplifier (ULCA) acting as travelling standard. Various measurements at direct currents between 0.16 nA and 13 nA were performed to verify the degree of agreement between the three national metrology institutes involved in the study. Consistency well within one part per million (ppm) was found. Due to harsh environmental conditions during shipment, the ULCA's transfer accuracy had been limited to about +/-0.4 ppm. Supplemental measurements performed at PTB indicate that further improvements in accuracy are possible. Relative uncertainties of 0.1 ppm are achieved by applying on-site calibration of the ULCA with a suitable cryogenic current comparator.

  14. 78 FR 33393 - Petition Requesting a Ban or Standard on Adult Portable Bed Rails

    Science.gov (United States)

    2013-06-04

    ... COMMISSION Petition Requesting a Ban or Standard on Adult Portable Bed Rails AGENCY: Consumer Product Safety... initiate proceedings under section 8 of the CPSA that would ban all adult portable bed rails because, they... adult portable bed rails. The Consumer Group, however, states that if the CPSC does not pursue a...

  15. Latent autoimmune diabetes of the adult: current knowledge and uncertainty

    OpenAIRE

    Laugesen, E; Østergaard, J A; Leslie, R D G

    2015-01-01

    Patients with adult-onset autoimmune diabetes have less Human Leucocyte Antigen (HLA)-associated genetic risk and fewer diabetes-associated autoantibodies compared with patients with childhood-onset Type 1 diabetes. Metabolic changes at diagnosis reflect a broad clinical phenotype ranging from diabetic ketoacidosis to mild non-insulin-requiring diabetes, also known as latent autoimmune diabetes of the adult (LADA). This latter phenotype is the most prevalent form of adult-onset autoimmune dia...

  16. Open Augmented Reality Standards: Current Activities in Standards- Development Organizations%Open Augmented Reality Standards: Current Activities in Standards- Development Organizations

    Institute of Scientific and Technical Information of China (English)

    Christine Perey

    2012-01-01

    Augmented reality (AR) has emerged from research laboratories and is now being accepted in other domains as an attractive way of visualizing information. Before AR can be used in the mass market, there are a number of obstacles that need to be overcome. Several of these can be overcome by adopting open standards. A global grassroots community seeking open, interoperable AR content and experiences began to take shape in early 2010. This community is working collaboratively to reduce the barriers to the flow of data from content provider to AR end user. Standards development organizations and industry groups that provide open interfaces for AR meet regularly to provide updates, identify complementary work, and seek harmonization. The community also identifies deployer and implementer needs, communicates requirements, and discusses emerging challenges that could be resolved with standards. In this article, we describe current activities in international standards-development organizations. We summarize the AR standards gap analysis and shed light on special considerations for using standards in mobile AR.

  17. Current state of standardization of radiodiagnostics in the GDR

    International Nuclear Information System (INIS)

    Starting from recommendations, tested for many years in radiodiagnostic institutions, standards for frequent radiological examination were elaborated, which have general obligation for the Public Health of the GDR. The standards concern parameters of the generation of radiographs, of methodical procedures during examination as well as of indication. The principle aspects of elaboration content, form and obligation of these standards are described. (author)

  18. Adult Wilms’ tumor – diagnosis and current therapy

    OpenAIRE

    Huszno, Joanna; Starzyczny–Słota, Danuta; Jaworska, Magdalena; Nowara, Elżbieta

    2013-01-01

    Introduction Wilms’ tumour is one of the commonest malignant tumours of childhood. It appears mainly in the first 5 years of life. Incidental examples of nephroblastoma in adults have been described in literature (about 3% of all described cases). There are diagnostic and therapeutic difficulties in that older age group. The preoperative diagnosis of nephroblastoma in adults is difficult because there are no specific radiographic findings that allow to distinguished it from the more common ad...

  19. Determination and comparison of computed tomography quantities in standard beams using standard adult and pediatric phantoms

    International Nuclear Information System (INIS)

    The computed tomography (CT) is a segment of diagnostic radiology that uses higher radiation dose comparing to others fields of conventional radiology. In 2011, for decreasing the uncertainty in the diagnostic radiology beams dosimetry, the International Atomic Energy Agency (IAEA) published an implementation on the Technical Reports Series no. 457 from 2007, which is a code of practice recommending procedures for calibration and dosimetry in diagnostic radiology field. The objective of this study was to compare CT measurements on standards beams using adult and pediatric phantoms. The same procedure was used for two types of phantoms. Measurements were performed on the surface of the phantoms obtaining values of entrance surface air kerma (Ke). Measurements were taken from 100 to 150 kV (RQT 8, 9 and RQT 10), with the center of the simulators positioned at a distance of 100 cm from the focal spot. The values for the CT quantities air kerma index (in free air, CK, and in phantom, CPMMA,C / CPMMA,P) and air kerma length product (PKA) were found. The results were significant and the largest difference between the two phantoms was found for the radiation quality RQT 10. (author)

  20. Determination and comparison of computed tomography quantities in standard beams using standard adult and pediatric phantoms

    Energy Technology Data Exchange (ETDEWEB)

    Martins, Elaine Wirney; Potiens, Maria da Penha A., E-mail: ewmartins@ipen.br, E-mail: mppalbu@ipen.br [Instituto de Pesquisas Energeticas e Nucleares (IPEN/CNEN-SP), Sao Paulo, SP (Brazil)

    2013-07-01

    The computed tomography (CT) is a segment of diagnostic radiology that uses higher radiation dose comparing to others fields of conventional radiology. In 2011, for decreasing the uncertainty in the diagnostic radiology beams dosimetry, the International Atomic Energy Agency (IAEA) published an implementation on the Technical Reports Series no. 457 from 2007, which is a code of practice recommending procedures for calibration and dosimetry in diagnostic radiology field. The objective of this study was to compare CT measurements on standards beams using adult and pediatric phantoms. The same procedure was used for two types of phantoms. Measurements were performed on the surface of the phantoms obtaining values of entrance surface air kerma (K{sub e}). Measurements were taken from 100 to 150 kV (RQT 8, 9 and RQT 10), with the center of the simulators positioned at a distance of 100 cm from the focal spot. The values for the CT quantities air kerma index (in free air, C{sub K}, and in phantom, C{sub PMMA,C} / C{sub PMMA,P}) and air kerma length product (P{sub KA}) were found. The results were significant and the largest difference between the two phantoms was found for the radiation quality RQT 10. (author)

  1. Predictors of young adults' representations of and behavior in their current romantic relationship: prospective tests of the prototype hypothesis.

    Science.gov (United States)

    Roisman, Glenn I; Collins, W Andrew; Sroufe, L Alan; Egeland, Byron

    2005-06-01

    Although attachment theory suggests that childhood experiences with caregivers serve as a prototype for adult love relationships, few explicit tests of this hypothesis exist in the literature. Drawing on data from a longitudinal cohort followed from birth to young adulthood, this paper examined correlates and antecedents of young adults' representations of and behavior in their current romantic relationship. Young adults who experienced a secure relationship with their primary caregiver in infancy as assessed in the Strange Situation were more likely to (a) produce coherent discourse regarding their current romantic partnership in the context of the Current Relationship Interview (CRI) and (b) have a higher quality romantic relationship as observed in standard conflict and collaboration tasks. Infant security accounted for variation in CRI security above and beyond the observed quality of participants' current romantic relationship. In contrast, the association between infant and romantic security was partially mediated by individuals' self-reports about their romantic experiences, suggesting that one plausible mechanism by which early experiences with caregivers shape young adults' representations of their attachments with romantic partners is through adults' expectations for and perceptions of love relationships. PMID:16096189

  2. Standard practice for characterization of coatings using conformable Eddy-Current sensors without coating reference standards

    CERN Document Server

    American Society for Testing and Materials. Philadelphia

    2011-01-01

    1.1 This practice covers the use of conformable eddy-current sensors for nondestructive characterization of coatings without standardization on coated reference parts. It includes the following: (1) thickness measurement of a conductive coating on a conductive substrate, (2) detection and characterization of local regions of increased porosity of a conductive coating, and (3) measurement of thickness for nonconductive coatings on a conductive substrate or on a conductive coating. This practice includes only nonmagnetic coatings on either magnetic (μ ≠ μ0) or nonmagnetic (μ = μ0) substrates. This practice can also be used to measure the effective thickness of a process-affected zone (for example, shot peened layer for aluminum alloys, alpha case for titanium alloys). For specific types of coated parts, the user may need a more specific procedure tailored to a specific application.

  3. Technical standardization of oil well abandonment: a review of current standards and technologies

    Energy Technology Data Exchange (ETDEWEB)

    Suzart, J. Walter P.; Pessoa, Laudemar; Paiva, Maria [Halliburton Energy Services (HES), Duncan, OK (United States)

    2008-07-01

    The objective of this study is to provide a new methodology for well abandonment. This practice is becoming more and more important because of the increasing number of production fields being abandoned. We strongly recommend a study of cement slurries properties for specific use in temporary and permanent abandonment plugs based on the estimation of the cement slurry hardened when placed in the well. By using specific additives, it is possible to achieve very stable slurries. For example, when permeability is reduced, formation fluid migration can be blocked and chemical reactions between the fluid and the slurry may be inhibited. With this objective, we present a laboratory investigation model and an example of slurry testing recommendation. During the abandonment operation, all records of the well characteristics should be maintained to include the reason for the abandonment, and location of fresh water, brine, and hydrocarbon zones that may exist. This documentation will also allow the analysis of solutions for the problems that originally caused the abandonment of the well. This data could be important for future use by environmental protection commissions to reopen or to drill an adjacent well. Given the high price of oil, it may now be economically feasible to reopen the well, if the reason for abandonment was low productivity. This way, a critical analysis of the current conditions of well and field abandonment in the country is presented. Based on this information, a review of the current standards is suggested. (author)

  4. Current Trends in Adult Degree Programs: How Public Universities Respond to the Needs of Adult Learners

    Science.gov (United States)

    Gast, Angela

    2013-01-01

    Although many adult students turn to online degree programs due to their flexibility and convenience, a majority of prospective adult learners prefer to take classes on traditional brick-and-mortar campuses. This chapter examines how public research universities create pathways to degree attainment and boost degree completion rates among adult…

  5. Current issues on a standard for surrogate pregnancy procedures

    OpenAIRE

    Ha, Jung-Ok

    2012-01-01

    While Korea does not have any legal statement on surrogacy, treatments are carried out in practice. As a result, every Institutional Review Board (IRB) of each fertility clinic faces an ethical predicament in reviewing each case. There is a need to arrange the institutions' own standards of surrogate pregnancy procedures before the establishment of national or professional regulation. This article examines the legal, social, and medical issues of surrogacy to help IRBs to judge their cases.

  6. Current issues on a standard for surrogate pregnancy procedures.

    Science.gov (United States)

    Ha, Jung-Ok

    2012-12-01

    While Korea does not have any legal statement on surrogacy, treatments are carried out in practice. As a result, every Institutional Review Board (IRB) of each fertility clinic faces an ethical predicament in reviewing each case. There is a need to arrange the institutions' own standards of surrogate pregnancy procedures before the establishment of national or professional regulation. This article examines the legal, social, and medical issues of surrogacy to help IRBs to judge their cases. PMID:23346523

  7. [Current model of breakfast for different age groups: children, a adolescents and adults].

    Science.gov (United States)

    Núñez, C; Cuadrado, C; Carbajal, A; Moreiras, O

    1998-01-01

    The objective of the present work is to assess the current breakfast model in different age groups: children between the ages of 6 and 12 years (n = 54); adolescents between the ages of 13 and 17 years (n = 174); and adults, older than 18 years of age (n = 252). For this a questionnaire has been designed that follows the standards of that used for a similar study by our team in 1984 on a sample of 1350 individuals. The modified and amplified questionnaire included open and closed questions about: the omission of breakfast and its causes, foods that are a part of breakfast, the most frequent types and the variations, the role of the second breakfast, the number of fasting hours since dinner, the time spent of breakfast, and the subjective opinion regarding the importance or not of having breakfast. 98.95% answer yes to the question do you have breakfast, but only 9% eats a nutritionally correct breakfast, one defined as that breakfast that supplies 20% of the total energy and includes foods from at least four different groups. All the children included some form of milk product in their breakfast. The adolescents consumed the lowest proportion of cereals (19.4%) and the highest proportion of pastries (24.2%). The percentage of adults who drink coffee with milk (57%) and sugar (37.7%) is significantly higher than that it the other two groups. Bread (37.7%), pastries (28.3%) and cookies (26.1%) are the solid foods eaten most by the adults. The children spend the longest time on breakfast. 35.9% of the sample varies their breakfast, 43.1% never does, and 21% does so sometimes. The average time elapsed between dinner and breakfast is 10.5 +/- 1.2 hours. It is advisable to have a more nutritionally balanced breakfast, including different foods from at least four groups, and including a greater variety in the menus. PMID:9780752

  8. Current Standards in the Management of Cerebral Metastases

    Directory of Open Access Journals (Sweden)

    Pablo Goetz

    2012-01-01

    Full Text Available The last 30 years have seen major changes in attitude toward patients with cerebral metastases. This paper aims to outline the major landmarks in this transition and the therapeutic strategies currently used. The controversies surrounding control of brain disease are discussed, and two emerging management trends are reviewed: tumor bed radiosurgery and salvage radiation.

  9. Current toxicological information as the basis for sulfur oxide standards.

    OpenAIRE

    Mehlman, M A

    1983-01-01

    The ambient air quality standard established in 1973 is 0.03 ppm annual average for sulfur dioxide and 0.075 mg/m3 for particulates. It is now generally believed that the toxicity of sulfur oxides in ambient air is significantly influenced by the coincident presence of particulates. Inhalation of 1 ppm of sulfur dioxide for 2 hr may produce alterations in pulmonary ventilatory function, both in normal and asthmatic subjects. Effects obtained at 0.5 ppm of sulfur dioxide are controversial and ...

  10. 3D standard brain of the red flour beetle Tribolium castaneum: a tool to study metamorphic development and adult plasticity

    Directory of Open Access Journals (Sweden)

    David Dreyer

    2010-03-01

    Full Text Available The red flour beetle Tribolium castaneum is emerging as a further standard insect model beside Drosophila. Its genome is fully sequenced and it is susceptible for genetic manipulations including RNA-interference. We use this beetle to study adult brain development and plasticity primarily with respect to the olfactory system. In the current study, we provide 3D standard brain atlases of freshly eclosed adult female and male beetles (A0. The atlases include eight paired and three unpaired neuropils including antennal lobes, optic lobe neuropils, mushroom body calyces and pedunculi, and central complex. For each of the two standard brains, we averaged brain areas of 20 individual brains. Additionally, we characterized eight selected olfactory glomeruli from 10 A0 female and male beetles respectively, which we could unequivocally recognize from individual to individual owing to their size and typical position in the antennal lobes. In summary, comparison of the averaged neuropil volumes revealed no sexual dimorphism in any of the reconstructed neuropils in A0 Tribolium brains. Both, the female and male 3D standard brain are also used for interspecies comparisons, and, very importantly, will serve as future volumetric references after genetical manipulation especially regarding metamorphic development and adult plasticity.

  11. Strengths and Limitations of Current Adult Nomograms for the Aorta Obtained by Noninvasive Cardiovascular Imaging.

    Science.gov (United States)

    Cantinotti, Massimiliano; Giordano, Raffaele; Clemente, Alberto; Assanta, Nadia; Murzi, Michele; Murzi, Bruno; Crocetti, Maura; Marotta, Marco; Scalese, Marco; Kutty, Shelby; Iervasi, Giorgio

    2016-07-01

    Normalized measurements for the evaluation of aortic disease severity are preferred to the adoption of generic cutoff values. The purpose of this review is to evaluate the strengths and limitations of currently available aortic nomograms by echocardiography, computed tomography (CT), and magnetic resonance imaging (MRI). A literature search was conducted accessing the National Library of Medicine using the keywords normal values, aorta, echocardiography, CT, and MRI. Addition of these keywords further refined the results: reference values, nomograms, aortic arch, and adults. Thirty studies were included in the final analysis. Despite the strengths noted in the recent investigations, multiple methodological and numerical limitations emerged. The numerical limitations included sample size limitation in most of the studies (only few investigations consisted of >800 subjects and many had 70-300), lack of aortic arch measurements, and paucity of data for non-Caucasian subjects. Methodological limitations consisted of lack of standardization in measurements (systole vs. diastole, internal vs. external border, axial vs. orthogonal planes), heterogeneity and data normalization issues (various age intervals used, body size often not evaluated, data expressed as observed values rather than estimated values by z-score), and study design issues. The designs were mostly retrospective with poorly defined inclusion and exclusion criteria. The nomograms presented range of normality with significant differences, but also with some reproducible pattern. Despite recent advances, multiple methodological or numerical limitations exist in adult nomograms for the aorta. Comprehensive nomograms of aortic dimensions at multiple levels including the aortic arch for different imaging techniques, involving a wide sample size, and using standardized methodology for measurements and data normalization are warranted. The availability of robust nomograms may encourage the use of personalized

  12. International Financial Reporting Standard 5 - Non-Current Assets Held for Sale and Discontinued Operations

    OpenAIRE

    Luka Crnkovic; Ivo Mijoc; Drazen Cucic

    2007-01-01

    International Financial Reporting Standard 5 has the working title Non-current assets held for sale and discontinued operations. This fi nancial reporting standard also represents a new group of standards along with the previous four, including existing International Accounting Standard, regardless if it concerns existing or revised standards, as a wish for further coordination of accounting regulations on world level. This idea is a concretisation of the wishes of International Accounting St...

  13. Standardized high current solid targets for cyclotron production of radionuclides

    International Nuclear Information System (INIS)

    The Cyclotron and Radiopharmaceuticals Department (CRP) is an advanced and modern facility that encompasses two essential components: radioisotope research, and radiopharmaceuticals manufacturing. Radiopharmaceuticals manufacturing program is not only quite unique, but also an essential component of King Faisal Specialist Hospital and Research Center (KFSH and RC) in providing quality patient care for the population of the Kingdom. Accurate diagnosis and therapy with medical imaging equipment requires quality radiopharmaceuticals that are available readily and with reliability. The CRP Department provides that quality and reliability. Research activities of the CRP Department are focused on developing new radiotracers with potential usefulness in biomedical research and clinical applications. Research projects consist of: developing cyclotron targetry for radioisotope production; developing synthesis methods for radiolabeling biomolecules; and developing analytical methods for quality control. The CRP Department operates a semi-commercial radiopharmaceuticals manufacturing program that supplies the diagnostic radioactive products to several hospitals in the Kingdom and neighboring countries. These products for clinical applications are produced according to the international standards of Good Manufacturing Practices of quality and efficacy. At the heart of the radioisotope program is a medium energy cyclotron capable of accelerating a number of particles for transformation of non-radioactive atoms into radionuclides that are the primary sources for research and development activities, and for preparing radiopharmaceuticals. In addition to having the only cyclotron facility in the region, KFSH and RC also has the only Positron Emission Tomography Center (PET) in this part of the world. This combination of cyclotron and the ultra modern PET facility translates into advanced and specialized care for the patients at KFSH and RC

  14. A New International Standard for "Actions from Waves and Currents on Coastal Structures"

    DEFF Research Database (Denmark)

    Tørum, Alf; Burcharth, Hans F.; Goda, Yoshimi;

    2007-01-01

    The International Organization for Standardization (ISO) is going to issue a new standard concerning "Actions from Waves and Currents on Coastal Structures," which becomes the first international standard in coastal engineering. It is composed of a normative part (29 pages), an informative part (...

  15. Certificate of Analysis, Standard Reference Material® 1849, Infant/Adult Nutritional Formula

    Science.gov (United States)

    Standard Reference material (SRM) 1849 is intended primarily for validation of methods for determining proximates, fatty acids, vitamins, elements and nucleotides in infant and adult nutritional formulas and similar materials. This SRM can also be used for quality assurance when assigning values to ...

  16. Adults with poor reading skills: How lexical knowledge interacts with scores on standardized reading comprehension tests.

    Science.gov (United States)

    McKoon, Gail; Ratcliff, Roger

    2016-01-01

    Millions of adults in the United States lack the necessary literacy skills for most living wage jobs. For students from adult learning classes, we used a lexical decision task to measure their knowledge of words and we used a decision-making model (Ratcliff's, 1978, diffusion model) to abstract the mechanisms underlying their performance from their RTs and accuracy. We also collected scores for each participant on standardized IQ tests and standardized reading tests used commonly in the education literature. We found significant correlations between the model's estimates of the strengths with which words are represented in memory and scores for some of the standardized tests but not others. The findings point to the feasibility and utility of combining a test of word knowledge, lexical decision, that is well-established in psycholinguistic research, a decision-making model that supplies information about underlying mechanisms, and standardized tests. The goal for future research is to use this combination of approaches to understand better how basic processes relate to standardized tests with the eventual aim of understanding what these tests are measuring and what the specific difficulties are for individual, low-literacy adults. PMID:26550803

  17. Insulin resistance modifies the association between obesity and current asthma in adults.

    Science.gov (United States)

    Cardet, Juan Carlos; Ash, Samuel; Kusa, Tope; Camargo, Carlos A; Israel, Elliot

    2016-08-01

    Insulin resistance potentiates the association between obesity and childhood asthma, but this relationship appears inconsistent in relatively small studies of adults. We investigated effect modification in adults using the National Health and Nutrition Examination Survey 2003-2012, a large, nationally representative database.Insulin resistance and a history of physician-diagnosed current asthma were obtained from 12 421 adults, ages 18-85 years. We used logistic regression to determine associations between obesity and current asthma, adjusting for age, sex, race/ethnicity, poverty income ratio and smoking status. An interaction term evaluated effect modification by insulin resistance of the obesity-asthma association.As expected, obesity was positively associated with current asthma. Insulin resistance modified this association, with obesity measured as body mass index, waist circumference or waist-to-height ratio. The relationship between obesity and current asthma was stronger with increasing insulin resistance tertiles (OR 2.05, 95% CI 2.76-3.00; p-value for interaction 0.03). This association was robust to adjustments for other components of the metabolic syndrome (hypertriglyceridaemia, hypertension, hyperglycaemia and systemic inflammation). None of these components were themselves effect modifiers of the obesity-asthma association.In this large, nationally representative sample, insulin resistance modified the association between obesity and current asthma in adults. Targeting insulin resistance may represent a novel therapeutic strategy for obese patients with asthma. PMID:27103388

  18. The Commission of Professors of Adult Education 2008 "Standards" as Evidenced in the Curricula of Doctoral Education in North America

    Science.gov (United States)

    Sonstrom, Wendy Jean; Rachal, John R.; Mohn, Richard S.

    2013-01-01

    In 2008, the Commission of Professors of Adult Education approved and published "Standards for Graduate Programs in Adult Education," an update of the 1986 "Standards." Using the program websites of the 37 North American programs ascertained to have doctoral programs in the field, this study evaluated all programs' course descriptions for…

  19. Current-Voltage Relationship for Late Na(+) Current in Adult Rat Ventricular Myocytes.

    Science.gov (United States)

    Clark, R B; Giles, W R

    2016-01-01

    It is now well established that the slowly inactivating component of the Na(+) current (INa-L) in the mammalian heart is a significant regulator of the action potential waveform. This insight has led to detailed studies of the role of INa-L in a number of important and challenging pathophysiological settings. These include genetically based ventricular arrhythmias (LQT 1, 2, and 3), ventricular arrhythmias arising from progressive cardiomyopathies (including diabetic), and proarrhythmic abnormalities that develop during local or global ventricular ischemia. Inhibition of INa-L may also be a useful strategy for management of atrial flutter and fibrillation. Many important biophysical parameters that characterize INa-L have been identified; and INa-L as an antiarrhythmia drug target has been studied extensively. However, relatively little information is available regarding (1) the ion transfer or current-voltage relationship for INa-L or (2) the time course of its reactivation at membrane potentials similar to the resting or diastolic membrane potential in mammalian ventricle. This chapter is based on our preliminary findings concerning these two very important physiological/biophysical descriptors for INa-L. Our results were obtained using whole-cell voltage clamp methods applied to enzymatically isolated rat ventricular myocytes. A chemical agent, BDF 9148, which was once considered to be a drug candidate in the Na(+)-dependent inotropic agent category has been used to markedly enhance INa-L current. BDF acts in a potent, selective, and reversible fashion. These BDF 9148 effects are compared and contrasted with the prototypical activator of INa-L, a sea anemone toxin, ATX II. PMID:27586292

  20. Critical analysis of the current treatment guidelines for complex PTSD in adults

    NARCIS (Netherlands)

    Jongh, A. de; Resick, P.A.; Zoellner, L.A.; Minnen, A. van; Lee, C.W.; Monson, C.M.; Foa, E.B.; Wheeler, K.; Broeke, E. ten; Feeny, N.; Rauch, S.A.M.; Chard, K.M.; Mueser, K.T.; Sloan, D.M.; Gaag, M. van der; Rothbaum, B.O.; Neuner, F.; Roos, C.J.A.M. de; Hehenkamp, L.M.J.; Rosner, R.; Bicanic, I.A.E.

    2016-01-01

    According to current treatment guidelines for Complex PTSD (cPTSD), psychotherapy for adults with cPTSD should start with a "stabilization phase". This phase, focusing on teaching self-regulation strategies, was designed to ensure that an individual would be better able to tolerate trauma-focused tr

  1. Preparation and characterization of standard reference material 1849 infant/adult nutritional formula.

    Science.gov (United States)

    Sharpless, Katherine E; Lindstrom, Richard M; Nelson, Bryant C; Phinney, Karen W; Rimmer, Catherine A; Sander, Lane C; Schantz, Michele M; Spatz, Rabia O; Thomas, Jeanice Brown; Turk, Gregory C; Wise, Stephen A; Wood, Laura J; Yen, James H

    2010-01-01

    Standard Reference Material (SRM) 1849 Infant/Adult Nutritional Formula has been issued by the National Institute of Standards and Technology (NIST) as a replacement for SRM 1846 Infant Formula, issued in 1996. Extraction characteristics of SRM 1846 have changed over time, as have NIST's analytical capabilities. While certified mass fraction values were provided for five constituents in SRM 1846 (four vitamins plus iodine), certified mass fraction values for 43 constituents are provided in SRM 1849 (fatty acids, elements, and vitamins) and reference mass fraction values are provided for an additional 43 constituents including amino acids and nucleotides, making it the most extensively characterized food-matrix SRM available from NIST. PMID:20922961

  2. Current Status of International Airborne Platform Data and Instrument Interface Standards

    Science.gov (United States)

    Freer, Matt; Webster, Chris; Freundinger, Larry

    2016-06-01

    Commission I of the International Society for Photogrammetric and Remote Sensing formed working group I/1 for the purpose of standardizing airborne platform interfaces. The primary mission of this working group is to promote the standardization of instrument interfaces, data formats, and supporting infrastructures; and to facilitate more efficient, flexible, and cost-effective international science flight operations. Within WGI/1 are a number of focused subgroups. This paper addresses the efforts of some of these subgroups having interdependent and overlapping interests; including the development of standard software interfaces for sensors, standardized approaches to management of information over potentially intermittent wireless data links, the development of standardized processing algorithms, and data archival format standards. The data in this report reflect the outcome of work-to-date in the current subgroups.

  3. CRITICAL ANALYSIS OF THE CURRENT TREATMENT GUIDELINES FOR COMPLEX PTSD IN ADULTS.

    Science.gov (United States)

    De Jongh, Ad; Resick, Patricia A; Zoellner, Lori A; van Minnen, Agnes; Lee, Christopher W; Monson, Candice M; Foa, Edna B; Wheeler, Kathleen; Broeke, Erik Ten; Feeny, Norah; Rauch, Sheila A M; Chard, Kathleen M; Mueser, Kim T; Sloan, Denise M; van der Gaag, Mark; Rothbaum, Barbara Olasov; Neuner, Frank; de Roos, Carlijn; Hehenkamp, Lieve M J; Rosner, Rita; Bicanic, Iva A E

    2016-05-01

    According to current treatment guidelines for Complex PTSD (cPTSD), psychotherapy for adults with cPTSD should start with a "stabilization phase." This phase, focusing on teaching self-regulation strategies, was designed to ensure that an individual would be better able to tolerate trauma-focused treatment. The purpose of this paper is to critically evaluate the research underlying these treatment guidelines for cPTSD, and to specifically address the question as to whether a phase-based approach is needed. As reviewed in this paper, the research supporting the need for phase-based treatment for individuals with cPTSD is methodologically limited. Further, there is no rigorous research to support the views that: (1) a phase-based approach is necessary for positive treatment outcomes for adults with cPTSD, (2) front-line trauma-focused treatments have unacceptable risks or that adults with cPTSD do not respond to them, and (3) adults with cPTSD profit significantly more from trauma-focused treatments when preceded by a stabilization phase. The current treatment guidelines for cPTSD may therefore be too conservative, risking that patients are denied or delayed in receiving conventional evidence-based treatments from which they might profit. PMID:26840244

  4. Current social functioning in adult-onset schizophrenia and its relation with positive symptoms

    OpenAIRE

    Kundu, Partha S.; Sinha, Vinod K.; Paul, Sarita E.; Pushpal Desarkar

    2013-01-01

    Background: In schizophrenia, relation exists between psychopathology and social functioning. Aim and Objectives: Determining relationship of positive symptoms with current social functioning in adult-onset (≥19 years) schizophrenia. Materials and Methods: Eighty schizophrenia patients [ICD-10-DCR], of both sexes (18-60 years), on follow-up for ≥6 months, with no change of diagnosis and without co-morbidities, having onset of illness ≥19 years of age, accompanied by informants having contact ...

  5. Adult human neural stem cell therapeutics: Current developmental status and prospect

    OpenAIRE

    Nam, Hyun; Lee, Kee-Hang; Nam, Do-Hyun; Joo, Kyeung Min

    2015-01-01

    Over the past two decades, regenerative therapies using stem cell technologies have been developed for various neurological diseases. Although stem cell therapy is an attractive option to reverse neural tissue damage and to recover neurological deficits, it is still under development so as not to show significant treatment effects in clinical settings. In this review, we discuss the scientific and clinical basics of adult neural stem cells (aNSCs), and their current developmental status as ce...

  6. Factors Influencing Adult Physical Health after Controlling for Current Health Conditions: Evidence from a British Cohort

    OpenAIRE

    Cheng, Helen; Furnham, Adrian

    2013-01-01

    This study explored a longitudinal data set of 6875 British adults examining the effects of parental social status (measured at birth), cognitive ability (at age 11 yrs), personality traits, education and occupational attainment on physical health and functioning (all measured at age 50 yrs), after taking account of current health conditions (number of illness). Correlation analysis showed that parental social class, childhood cognitive ability, education and occupation, and two personality t...

  7. Strategies of bringing drug product marketing applications to meet current regulatory standards.

    Science.gov (United States)

    Wu, Yan; Freed, Anita; Lavrich, David; Raghavachari, Ramesh; Huynh-Ba, Kim; Shah, Ketan; Alasandro, Mark

    2015-08-01

    In the past decade, many guidance documents have been issued through collaboration of global organizations and regulatory authorities. Most of these are applicable to new products, but there is a risk that currently marketed products will not meet the new compliance standards during audits and inspections while companies continue to make changes through the product life cycle for continuous improvement or market demands. This discussion presents different strategies to bringing drug product marketing applications to meet current and emerging standards. It also discusses stability and method designs to meet process validation and global development efforts. PMID:26024722

  8. Difference of Sodium Currents between Pediatric and Adult Human Atrial Myocytes: Evidence for Developmental Changes of Sodium Channels

    Directory of Open Access Journals (Sweden)

    Benzhi Cai, Xiaoqin Mu, Dongmei Gong, Shulin Jiang, Jianping Li, Qingxin Meng, Yunlong Bai, Yanju Liu, Xinyue Wang, Xueying Tan, Baofeng Yang, Yanjie Lu

    2011-01-01

    Full Text Available Voltage-gated calcium currents and potassium currents were shown to undergo developmental changes in postnatal human and animal cardiomocytes. However, so far, there is no evidence whether sodium currents also presented the developmental changes in postnatal human atrial cells. The aim of this study was to observe age-related changes of sodium currents between pediatric and adult atrial myocytes. Human atrial myocytes were acutely isolated and the whole-cell patch clamp technique was used to record sodium currents isolated from pediatric and adult atrial cardiomocytes. The peak amplitude of sodium currents recorded in adult atrial cells was significantly larger than that in pediatric atrial myocytes. However, there was no significant difference of the activation voltage for peak sodium currents between two kinds of atrial myocytes. The time constants for the activation and inactivation of sodium currents were smaller in adult atria than pediatric atria. The further study revealed that the voltage-dependent inactivation of sodium currents were more slow in adult atrial cardiomyocytes than pediatric atrial cells. A significant difference was also observed in the recovery process of sodium channel from inactivation. In summary, a few significant differences were demonstrated in sodium currents characteristics between pediatric and adult atrial myocytes, which indicates that sodium currents in human atria also undergo developmental changes.

  9. Low dose nicotine self-administration is reduced in adult male rats naïve to high doses of nicotine: Implications for nicotine product standards

    OpenAIRE

    Smith, Tracy T.; Schassburger, Rachel L.; Buffalari, Deanne M.; Sved, Alan F.; Donny, Eric C.

    2014-01-01

    Product standards that greatly reduce the content of nicotine within cigarettes may result in improved public health. The present study used an animal model to investigate whether individuals who start smoking following implementation of regulation may be affected differently from current smokers who form the basis of most clinical studies. One group of adult male rats (n=14/group) acquired nicotine self-administration at a high nicotine dose (60 μg/kg/infusion) before experiencing a reductio...

  10. Factors influencing adult physical health after controlling for current health conditions: evidence from a british cohort.

    Directory of Open Access Journals (Sweden)

    Helen Cheng

    Full Text Available This study explored a longitudinal data set of 6875 British adults examining the effects of parental social status (measured at birth, cognitive ability (at age 11 yrs, personality traits, education and occupational attainment on physical health and functioning (all measured at age 50 yrs, after taking account of current health conditions (number of illness. Correlation analysis showed that parental social class, childhood cognitive ability, education and occupation, and two personality traits (Emotional Stability/Neuroticism, and Conscientiousness were all significantly associated with adult physical health variables. Structural equation modelling showed that health conditions and personality traits were significantly, and inversely, associated with physical health (indicated by good daily physical functioning, relative absence of pain, perceived health, and low level of limitations at work due to physical health. Parental social status, childhood intelligence, educational and occupational attainment were all modestly, but significantly and directly, associated with adult physical health. The effect of childhood intelligence on adult physical health was, in part, mediated through Emotional Stability and Conscientiousness. After controlling for health conditions Emotional Stability was the strongest predictor of physical health. Implications and limitations are discussed.

  11. Standard Operating Procedures for PET/CT: A Practical Approach for Use in Adult Oncology

    International Nuclear Information System (INIS)

    of operating procedures for FDG-PET/CT imaging in adult oncology patients. The text is based on consensus and agreement among the authors, following a systematic approach of relying on personal experience and the available scientific evidence on all the subjects included. Due to the evolving nature of PET/CT imaging, which is a rapidly growing technology, this publication will undoubtedly need to be updated on a regular basis. It may well be that each PET/CT centre will have to modify the recommendations provided here to suit its own particular circumstances, according to, inter alia, the type of scanner, patient population, use of intravenous contrast, availability of FDG, professional staff experience, local regulations and preferences of referring physicians. The information provided here is felt to be important in the light of the growing need to standardize and optimize the way PET/CT scans are performed, not only to enable trials using FDG-PET/CT in different institutions to be compared and correlated, but also to allow for more accurate comparisons of scans performed on the same patient at different points in time at a single institution. This is important when assessing the response to cancer therapy, and especially so when this evaluation is performed early and after using novel targeted treatments that very often only produce changes in metabolic activity and not in lesion/tumour size. This is the reason why strictly following a correct imaging protocol is crucial. The reliability of the PET/CT imaging information in cancer patients depends on trustworthy and consistently applied protocols. This issue has current relevance in drug discovery and development, where PET/CT imaging with FDG and other radiotracers is viewed by the pharmaceutical industry as potentially useful for shortening the process of clinical validation of new drugs

  12. Modeling of tube current modulation methods in computed tomography dose calculations for adult and pregnant patients

    International Nuclear Information System (INIS)

    The comparatively high dose and increasing frequency of computed tomography (CT) examinations have spurred the development of techniques for reducing radiation dose to imaging patients. Among these is the application of tube current modulation (TCM), which can be applied either longitudinally along the body or rotationally along the body, or both. Existing computational models for calculating dose from CT examinations do not include TCM techniques. Dose calculations using Monte Carlo methods have been previously prepared for constant-current rotational exposures at various positions along the body and for the principle exposure projections for several sets of computational phantoms, including adult male and female and pregnant patients. Dose calculations from CT scans with TCM are prepared by appropriately weighting the existing dose data. Longitudinal TCM doses can be obtained by weighting the dose at the z-axis scan position by the relative tube current at that position. Rotational TCM doses are weighted using the relative organ doses from the principle projections as a function of the current at the rotational angle. Significant dose reductions of 15% to 25% to fetal tissues are found from simulations of longitudinal TCM schemes to pregnant patients of different gestational ages. Weighting factors for each organ in rotational TCM schemes applied to adult male and female patients have also been found. As the application of TCM techniques becomes more prevalent, the need for including TCM in CT dose estimates will necessarily increase. (author)

  13. Bioelectrical impedance analysis (BIA): a proposal for standardization of the classical method in adults

    International Nuclear Information System (INIS)

    The accuracy of BIA measurements is limited by different sources of error such as physical model, cross sectional area, ethnicity, body hydration, age and level of body fat among other variables. Equation for each population is required as they can produce overestimation when manufacturer's equations are used. The classical measurements hand to foot has shown better correlation against hydrodensitometry than foot to foot or hand to hand. However there is a lack for an accepted standard of BIA procedures. This is compounded when there is not a good report of the BIA study's methodology; hence the comparability between the results is poor and reduces the reliability of the method. Perhaps, standardization of methods would be the first step for BIA studies to move forward and subsequently improve its accuracy. Standardized procedures could also minimize the impact of these variables on studies results. The aim of this study was to propose a protocol as a checklist to standardize BIA procedures and produce comparable results from future studies performed with the classic hand-foot configuration in adults.

  14. Regional hyperthermia combined with chemotherapy in paediatric, adolescent and young adult patients: current and future perspectives.

    Science.gov (United States)

    Seifert, Georg; Budach, Volker; Keilholz, Ulrich; Wust, Peter; Eggert, Angelika; Ghadjar, Pirus

    2016-01-01

    Here we evaluate the current status of clinical research on regional hyperthermia (RHT) in combination with chemotherapy or radiation therapy in paediatric oncology.Data were identified in searches of MEDLINE, Current Contents, PubMed, and references from relevant articles using medical subject headings including hyperthermia, cancer, paediatric oncology, children, radiation therapy and chemotherapy. Currently, only two RHT centres exist in Europe which treat children. Clinical RHT research in paediatric oncology has as yet been limited to children with sarcomas and germ cell tumours that respond poorly to or recur after chemotherapy. RHT is a safe and effective treatment delivering local thermic effects, which may also stimulate immunological processes via heat-shock protein reactions. RHT is used chiefly in children and adolescents with sarcomas or germ cell tumours located in the abdomino-pelvic region, chest wall or extremities to improve operability or render the tumour operable. It could potentially be combined with radiation therapy in a post-operative R1 setting where more radical surgery is not possible or combined with chemotherapy instead of radiation therapy in cases where the necessary radiation dose is impossible to achieve or would have mutilating consequences. RHT might also be an option for chemotherapy intensification in the neoadjuvant first-line treatment setting for children and adolescents, as was recently reflected in the promising long-term outcome data in adults with high-risk soft tissue sarcomas (EORTC 62961/ESHO trial).The limited data available indicate that combining RHT with chemotherapy is a promising option to treat germ cell tumours and, potentially, sarcomas. RHT may also be beneficial in first-line therapy in children, adolescents and young adults. The research should focus on optimising necessary technical demands and then initiate several clinical trials incorporating RHT into interdisciplinary treatment of children

  15. Regional hyperthermia combined with chemotherapy in paediatric, adolescent and young adult patients: current and future perspectives

    International Nuclear Information System (INIS)

    Here we evaluate the current status of clinical research on regional hyperthermia (RHT) in combination with chemotherapy or radiation therapy in paediatric oncology. Data were identified in searches of MEDLINE, Current Contents, PubMed, and references from relevant articles using medical subject headings including hyperthermia, cancer, paediatric oncology, children, radiation therapy and chemotherapy. Currently, only two RHT centres exist in Europe which treat children. Clinical RHT research in paediatric oncology has as yet been limited to children with sarcomas and germ cell tumours that respond poorly to or recur after chemotherapy. RHT is a safe and effective treatment delivering local thermic effects, which may also stimulate immunological processes via heat-shock protein reactions. RHT is used chiefly in children and adolescents with sarcomas or germ cell tumours located in the abdomino-pelvic region, chest wall or extremities to improve operability or render the tumour operable. It could potentially be combined with radiation therapy in a post-operative R1 setting where more radical surgery is not possible or combined with chemotherapy instead of radiation therapy in cases where the necessary radiation dose is impossible to achieve or would have mutilating consequences. RHT might also be an option for chemotherapy intensification in the neoadjuvant first-line treatment setting for children and adolescents, as was recently reflected in the promising long-term outcome data in adults with high-risk soft tissue sarcomas (EORTC 62961/ESHO trial). The limited data available indicate that combining RHT with chemotherapy is a promising option to treat germ cell tumours and, potentially, sarcomas. RHT may also be beneficial in first-line therapy in children, adolescents and young adults. The research should focus on optimising necessary technical demands and then initiate several clinical trials incorporating RHT into interdisciplinary treatment of children

  16. Electric current in flares ribbons: from the standard model in 3D to observations

    CERN Document Server

    Janvier, Miho; Bommier, V; Schmieder, B; Démoulin, P; Pariat, E

    2014-01-01

    The paper presents for the first time a quantification of the photospheric electric current ribbon evolutions during an eruptive flare, accurately predicted by the standard 3D flare model. The standard flare model in 3D has been developed with the MHD code OHM, which models the evolution of an unstable flux rope. Through a series of paper, the model has been successful in explaining observational characteristics of eruptive flares, as well as the intrinsic 3D reconnection mechanism. Such a model also explains the increase of the photospheric currents as a consequence of the evolution of the coronal current layer where reconnection takes place. The photospheric footprints of the 3D current layer reveal a ribbon shape structure. In the present paper, the evolution of the current density is analyzed for the X-class flare that occurred on 15/02/2011 in AR 11158. We first describe the structural evolution of the high vertical current density regions derived with the UNNOFIT inversion code from magnetograms (HMI, e...

  17. Training in clinical forensic medicine in the UK--perceptions of current regulatory standards.

    Science.gov (United States)

    Stark, Margaret M; Norfolk, Guy A

    2011-08-01

    As clinical forensic medicine (CFM) is not currently recognised as a speciality in the UK there are no nationally agreed mandatory standards for training forensic physicians in either general forensic (GFM) or sexual offence medicine (SOM). The General Medical Council (GMC), the medical regulator in the UK, has issued clear standards for training in all specialities recommending that "trainees must be supported to acquire the necessary skills and experience through induction, effective educational supervision, an appropriate workload and time to learn". In order to evaluate the current situation in the field of clinical forensic medicine, doctors who have recently (within the last two years) started working in the field "trainees" (n = 38), and trainers (n = 61) with responsibility for clinical and educational supervision of new trainees, were surveyed by questionnaire to gather their perceptions of how the relevant GMC standards are being met in initial on-the-job training. Telephone interviews were performed with eleven doctors working as clinical or medical directors to determine their views. It is clear that currently the quality of training in CFM is sub-standard and inconsistent and that the published standards, as to the minimum requirement for training that must be met by post-graduate medical and training providers at all levels, are not being met. The Faculty of Forensic and Legal Medicine (FFLM) needs to set explicit minimum standards which will comply with the regulator and work to pilot credentialing for forensic physicians. A number of recommendations are made for urgent FFLM development. PMID:21771557

  18. Standardization of Administered Activities in Pediatric Nuclear Medicine: A Report of the First Nuclear Medicine Global Initiative Project, Part 2-Current Standards and the Path Toward Global Standardization.

    Science.gov (United States)

    Fahey, Frederic H; Bom, Henry Hee-Seung; Chiti, Arturo; Choi, Yun Young; Huang, Gang; Lassmann, Michael; Laurin, Norman; Mut, Fernando; Nuñez-Miller, Rodolfo; O'Keeffe, Darin; Pradhan, Prasanta; Scott, Andrew M; Song, Shaoli; Soni, Nischal; Uchiyama, Mayuki; Vargas, Luis

    2016-07-01

    The Nuclear Medicine Global Initiative (NMGI) was formed in 2012 and consists of 13 international organizations with direct involvement in nuclear medicine. The underlying objectives of the NMGI are to promote human health by advancing the field of nuclear medicine and molecular imaging, encourage global collaboration in education, and harmonize procedure guidelines and other policies that ultimately lead to improvements in quality and safety in the field throughout the world. For its first project, the NMGI decided to consider the issues involved in the standardization of administered activities in pediatric nuclear medicine. It was decided to divide the final report of this project into 2 parts. Part 1 was published in this journal in the spring of 2015. This article presents part 2 of the final report. It discusses current standards for administered activities in children and adolescents that have been developed by various professional organizations. It also presents an evaluation of the current practice of pediatric nuclear medicine specifically with regard to administered activities as determined by an international survey of 313 nuclear medicine clinics and centers from 29 countries. Lastly, it provides recommendations for a path toward global standardization of the administration of radiopharmaceuticals in children. PMID:27033894

  19. Improved reading measures in adults with dyslexia following transcranial direct current stimulation treatment.

    Science.gov (United States)

    Heth, Inbahl; Lavidor, Michal

    2015-04-01

    To better understand the contribution of the dorsal system to word reading, we explored transcranial direct current stimulation (tDCS) effects when adults with developmental dyslexia received active stimulation over the visual extrastriate area MT/V5, which is dominated by magnocellular input. Stimulation was administered in 5 sessions spread over two weeks, and reading speed and accuracy as well as reading fluency were assessed before, immediately after, and a week after the end of the treatment. A control group of adults with developmental dyslexia matched for age, gender, reading level, vocabulary and block-design WAIS-III sub-tests and reading level was exposed to the same protocol but with sham stimulation. The results revealed that active, but not sham stimulation, significantly improved reading speed and fluency. This finding suggests that the dorsal stream may play a role in efficient retrieval from the orthographic input lexicon in the lexical route. It also underscores the potential of tDCS as an intervention tool for improving reading speed, at least in adults with developmental dyslexia. PMID:25701796

  20. Cost-effectiveness of early versus standard antiretroviral therapy in HIV-infected adults in Haiti.

    Directory of Open Access Journals (Sweden)

    Serena P Koenig

    2011-09-01

    Full Text Available BACKGROUND: In a randomized clinical trial of early versus standard antiretroviral therapy (ART in HIV-infected adults with a CD4 cell count between 200 and 350 cells/mm³ in Haiti, early ART decreased mortality by 75%. We assessed the cost-effectiveness of early versus standard ART in this trial. METHODS AND FINDINGS: Trial data included use of ART and other medications, laboratory tests, outpatient visits, radiographic studies, procedures, and hospital services. Medication, laboratory, radiograph, labor, and overhead costs were from the study clinic, and hospital and procedure costs were from local providers. We evaluated cost per year of life saved (YLS, including patient and caregiver costs, with a median of 21 months and maximum of 36 months of follow-up, and with costs and life expectancy discounted at 3% per annum. Between 2005 and 2008, 816 participants were enrolled and followed for a median of 21 months. Mean total costs per patient during the trial were US$1,381 for early ART and US$1,033 for standard ART. After excluding research-related laboratory tests without clinical benefit, costs were US$1,158 (early ART and US$979 (standard ART. Early ART patients had higher mean costs for ART (US$398 versus US$81 but lower costs for non-ART medications, CD4 cell counts, clinically indicated tests, and radiographs (US$275 versus US$384. The cost-effectiveness ratio after a maximum of 3 years for early versus standard ART was US$3,975/YLS (95% CI US$2,129/YLS-US$9,979/YLS including research-related tests, and US$2,050/YLS excluding research-related tests (95% CI US$722/YLS-US$5,537/YLS. CONCLUSIONS: Initiating ART in HIV-infected adults with a CD4 cell count between 200 and 350 cells/mm³ in Haiti, consistent with World Health Organization advice, was cost-effective (US$/YLS <3 times gross domestic product per capita after a maximum of 3 years, after excluding research-related laboratory tests. TRIAL REGISTRATION: ClinicalTrials.gov NCT00120510.

  1. Cost-Effectiveness of Early Versus Standard Antiretroviral Therapy in HIV-Infected Adults in Haiti

    Science.gov (United States)

    Koenig, Serena P.; Bang, Heejung; Severe, Patrice; Jean Juste, Marc Antoine; Ambroise, Alex; Edwards, Alison; Hippolyte, Jessica; Fitzgerald, Daniel W.; McGreevy, Jolion; Riviere, Cynthia; Marcelin, Serge; Secours, Rode; Johnson, Warren D.; Pape, Jean W.; Schackman, Bruce R.

    2011-01-01

    Background In a randomized clinical trial of early versus standard antiretroviral therapy (ART) in HIV-infected adults with a CD4 cell count between 200 and 350 cells/mm3 in Haiti, early ART decreased mortality by 75%. We assessed the cost-effectiveness of early versus standard ART in this trial. Methods and Findings Trial data included use of ART and other medications, laboratory tests, outpatient visits, radiographic studies, procedures, and hospital services. Medication, laboratory, radiograph, labor, and overhead costs were from the study clinic, and hospital and procedure costs were from local providers. We evaluated cost per year of life saved (YLS), including patient and caregiver costs, with a median of 21 months and maximum of 36 months of follow-up, and with costs and life expectancy discounted at 3% per annum. Between 2005 and 2008, 816 participants were enrolled and followed for a median of 21 months. Mean total costs per patient during the trial were US$1,381 for early ART and US$1,033 for standard ART. After excluding research-related laboratory tests without clinical benefit, costs were US$1,158 (early ART) and US$979 (standard ART). Early ART patients had higher mean costs for ART (US$398 versus US$81) but lower costs for non-ART medications, CD4 cell counts, clinically indicated tests, and radiographs (US$275 versus US$384). The cost-effectiveness ratio after a maximum of 3 years for early versus standard ART was US$3,975/YLS (95% CI US$2,129/YLS–US$9,979/YLS) including research-related tests, and US$2,050/YLS excluding research-related tests (95% CI US$722/YLS–US$5,537/YLS). Conclusions Initiating ART in HIV-infected adults with a CD4 cell count between 200 and 350 cells/mm3 in Haiti, consistent with World Health Organization advice, was cost-effective (US$/YLS <3 times gross domestic product per capita) after a maximum of 3 years, after excluding research-related laboratory tests. Trial registration ClinicalTrials.gov NCT00120510 Please see

  2. Analysis of the Current Technical Issues on ASME Code and Standard for Nuclear Mechanical Design(2009)

    International Nuclear Information System (INIS)

    This report describes the analysis on the current revision movement related to the mechanical design issues of the U.S ASME nuclear code and standard. ASME nuclear mechanical design in this report is composed of the nuclear material, primary system, secondary system and high temperature reactor. This report includes the countermeasures based on the ASME Code meeting for current issues of each major field. KAMC(ASME Mirror Committee) of this project is willing to reflect a standpoint of the domestic nuclear industry on ASME nuclear mechanical design and play a technical bridge role for the domestic nuclear industry in ASME Codes application

  3. U.S. elevated temperature structural design standards. Current status and future directions

    International Nuclear Information System (INIS)

    The technical content and scope of coverage of nuclear structural design standards reflects their role in the procurement and licensing of nuclear power plants. In the United States licensing of nuclear power plants requires that the owner of the plant demonstrate that the health and safety of the public is not and will not be endangered by the operation of the plant. That demonstration is a matter of public record and is subject to review and criticism, in an advisary hearing, by state and federal licensing authorities and any member of the public. National concensus structural design standards have been one of the responses to this form of power plant licensing since they effectively remove structural design rules from the arena of conflict. The resulting national standards tend to be generally applicable to all plant types and to relatively diverse operating conditions and material types. Code Case 1592 which is the elevated temperature nuclear design criteria is an example of such a national standard. Its development was the spontaneous outgrowth of the U.S. LMFBR program which demanded the best possible assurance of integrity. Being written within the framework of the ASME Boiler Code it was developed as a general standard, not just a special case for the FFTF or the CRBR Project. Now that its contents are becoming known and accepted there is a desire to apply them to other areas (core support structures, component supports, containment vessels, and to non-radioactive systems). There also are efforts being made to refine the definition of the interface between low temperature rules and creep-temperature rules. In this paper the development of Code Case 1592 is traced. The current and future technical content of the elevated temperature design standards for nuclear service are discussed. The relationship of Code Case 1592 to other ASME Standards and to certain U.S. industrial, governmental and regulatory standards is examined. (author)

  4. Use of Adult Stem Cells for Cartilage Tissue Engineering: Current Status and Future Developments

    Directory of Open Access Journals (Sweden)

    Catherine Baugé

    2015-01-01

    Full Text Available Due to their low self-repair ability, cartilage defects that result from joint injury, aging, or osteoarthritis, are the most often irreversible and are a major cause of joint pain and chronic disability. So, in recent years, researchers and surgeons have been working hard to elaborate cartilage repair interventions for patients who suffer from cartilage damage. However, current methods do not perfectly restore hyaline cartilage and may lead to the apparition of fibro- or hypertrophic cartilage. In the next years, the development of new strategies using adult stem cells, in scaffolds, with supplementation of culture medium and/or culture in low oxygen tension should improve the quality of neoformed cartilage. Through these solutions, some of the latest technologies start to bring very promising results in repairing cartilage from traumatic injury or chondropathies. This review discusses the current knowledge about the use of adult stem cells in the context of cartilage tissue engineering and presents clinical trials in progress, as well as in the future, especially in the field of bioprinting stem cells.

  5. Standard procedures for adults in accredited sleep medicine centres in Europe

    DEFF Research Database (Denmark)

    Fischer, Jürgen; Dogas, Zoran; Bassetti, Claudio L;

    2012-01-01

    The present paper describes standardized procedures within clinical sleep medicine. As such, it is a continuation of the previously published European guidelines for the accreditation of sleep medicine centres and European guidelines for the certification of professionals in sleep medicine, aimed...... at creating standards of practice in European sleep medicine. It is also part of a broader action plan of the European Sleep Research Society, including the process of accreditation of sleep medicine centres and certification of sleep medicine experts, as well as publishing the Catalogue of Knowledge...... and Skills for sleep medicine experts (physicians, non-medical health care providers, nurses and technologists), which will be a basis for the development of relevant educational curricula. In the current paper, the standard operational procedures sleep medicine centres regarding the diagnostic and...

  6. The development of national quality performance standards for disposable absorbent products for adult incontinence.

    Science.gov (United States)

    Muller, Nancy; McInnis, Elaine

    2013-09-01

    Disposable absorbent products are widely used in inpatient care settings and in the community to manage adult urinary and fecal incontinence, but few product standards exist to help guide their production or optimal use. Increasing costs and reduced revenues have caused a number of states to evaluate absorbent product use among persons who receive care at home with the assistance of the Medicaid Waiver Program, further increasing concerns about the lack of product performance standards. To address these issues, the National Association For Continence (NAFC) formed a council of experts and key stakeholders with the objective of establishing national, independent quality performance standards for disposable absorbent products provided by states to Waiver Program recipients. The Council consisted of representatives from five purposefully selected states, technical directors from six nonwoven product manufacturers, an officer of the nonwoven manufactures trade association, a delegate from an academic nursing program and professional societies, a family caregiver, and a patient representative. Following a consensus method and guidelines for use, nine specific recommendations were developed, posted for public comment, and further refined. Final recommendations for product performance assessment include: rewet rate (a measure of a product's ability to withstand multiple incontinent episodes between changes), rate of acquisition (a measure of the speed at which urine is drawn away from the skin by a product, product retention capacity (a measure of a product's capacity to hold fluid without rewetting the skin), sizing options, absorbency levels, product safety, closure technology, breathable zones (a measure of the air permeability across a textile-like fabric at a controlled differential pressure), and elasticity. The Council also set values for and recommended four quantifiable parameters, and the testing methodology associated with each, to help consumers and states

  7. Looking back: the experience of first sexual intercourse and current sexual adjustment in young heterosexual adults.

    Science.gov (United States)

    Reissing, Elke D; Andruff, Heather L; Wentland, Jocelyn J

    2012-01-01

    A young person's first consensual sexual intercourse experience is often a remarkable and memorable experience. However, little systematic information exists regarding contextual factors of first intercourse, the affective salience of the experience, possible effects on sexual attitudes and beliefs, and subsequent sexual development and adjustment. This retrospective study aimed to examine these in a sample of 475 young adults. Overall, young men and women experienced intercourse for the first time around age 17, were in a committed relationship, and reported positive affective responses. Affective reactions to the first sexual intercourse experience, sexual self-efficacy, sexual aversion, and age at first intercourse affected individuals' current sexual adjustment; however, only sexual self-efficacy mediated between first intercourse and current sexual adjustment in young men and women. Older age at first intercourse was associated with less sexual self-efficacy and lower current sexual adjustment for women. This study provides initial data to suggest that the first sexual intercourse experience significantly impacts current sexual adjustment by affecting beliefs about sexual self-efficacy. PMID:21161815

  8. Standardization of the Czech version of the Snyder´s Adult dispositional hope scale

    Directory of Open Access Journals (Sweden)

    Marie Ocisková

    2016-01-01

    Full Text Available Hope is one of important factors affecting the psychological state of individuals. It influences well-being and self-esteem, academic and athletic performance, and even the probability of repeated incarceration of offenders. It also predicts the efficacy of the systematic psychotherapy of mental disorders, as well as the supportive psychotherapy in patients with oncologic illnesses. Hope has a central position in positive and clinical psychology. The aim of the presented work was to translate the adult dispositional hope scale into Czech, verify its psychometric properties and develop the norms for interpreting the resulting scores. The scale could be helpful both in mental health research and practice. 394 healthy adults participated in the study. The average age of the probands was 27.1 + 11.7 years. There were more women (n = 303; i.e. 76.9 % than men. The most common level of education was secondary (n = 309; 78.4 %. The participants were mainly students (n = 273; 69.3 % or employees and self-employed individuals (n = 113; 28.7 %. Most of them were single (n = 300; 76.1 % or married (n = 84; 21.3 %. The Adult Dispositional Hope Scale consists of 12 items. Four items measure pathways thinking (i.e. the ability to find ways to achieve one's goals and four items assess agency (i.e. goal-directed energy. The remaining four items are fillers that are not interpreted. Apart from this scale, all participants completed a demographic questionnaire and the second version of the Beck Depression Inventory. The statistical analyses consisted of the Cronbach's alpha and Spearman-Brown coefficient analysis, the exploratory and confirmatory factor analysis, the correlation between the standardized scale and the Beck Depression Inventory-II, and finally the creation of the norms based on the stens. The overall rate of hope was not statistically significantly associated with the subjects' age (Spearman r = -0.06, non-significant, nor with their sex (Mann

  9. Lifelong education for older adults in Malta: Current trends and future visions

    Science.gov (United States)

    Formosa, Marvin

    2012-04-01

    With European demographic developments causing a decline of the available workforce in the foreseeable future and the unsustainability of dominant pay-as-you-go pension systems (where contributions from the current workforce sustain pensioners), governments need to come up with strategies to deal with this upcoming challenge and to adjust their policies. Based on a study carried out between September 2009 and May 2010, this article evaluates the policies guiding late-life education in Malta, as well as the local plethora of learning opportunities for older adult education, and participation rates. The Maltese government is committed to supporting the inclusion of older persons (aged 60+) in lifelong education policies and programmes, to the extent that local studies have uncovered a recent rise in the overall participation of older adults in formal, non-formal and informal areas of learning. While the present and future prospects for late-life education in Malta seem promising, a critical scrutiny of present ideologies and trends finds the field to be no more than seductive rhetoric. Though the coordination of late-life education in Malta does result in various social benefits to older learners and Maltese society in general, it also occurs within five intersecting lines of inequality - namely an economic rationale, elitism, gender bias, the urban-rural divide and third ageism. This article ends by proposing policy recommendations for the future of late-life education.

  10. Test of the depression distress amplification model in young adults with elevated risk of current suicidality.

    Science.gov (United States)

    Capron, Daniel W; Lamis, Dorian A; Schmidt, Norman B

    2014-11-30

    Suicide is a leading cause of death among young adults and the rate of suicide has been increasing for decades. A depression distress amplification model posits that young adults with comorbid depression and anxiety have elevated suicide rates due to the intensification of their depressive symptoms by anxiety sensitivity cognitive concerns. The current study tested the effects of anxiety sensitivity subfactors as well as the depression distress amplification model in a very large sample of college students with elevated suicide risk. Participants were 721 college students who were at elevated risk of suicidality (scored>0 on the Beck Scale for Suicide Ideation). Consistent with prior work, anxiety sensitivity cognitive concerns, but not physical or social concerns, were associated with suicidal ideation. Consistent with the depression distress amplification model, in individuals high in depression, anxiety sensitivity cognitive concerns predicted elevated suicidal ideation but not among those with low depression. The results of this study corroborate the role of anxiety sensitivity cognitive concerns and the depression distress amplification model in suicidal ideation among a large potentially high-risk group of college students. The depression distress amplification model suggests a specific mechanism, anxiety sensitivity cognitive concerns, that may be responsible for increased suicide rates among those with comorbid anxiety and depression. PMID:25063018

  11. Current issues with standards in the measurement and documentation of human skeletal anatomy.

    Science.gov (United States)

    Magee, Justin; McClelland, Brian; Winder, John

    2012-09-01

    Digital modeling of human anatomy has become increasingly important and relies on well-documented quantitative anatomy literature. This type of documentation is common for the spine and pelvis; however, significant issues exist due to the lack of standardization in measurement and technique. Existing literature on quantitative anatomy for the spine and pelvis of white adults (aged 18-65 years, separated into decadal categories) was reviewed from the disciplines of anatomy, manipulative therapy, anthropometrics, occupational ergonomics, biomechanics and forensic science. The data were unified into a single normative model of the sub-axial spine. Two-dimensional orthographic drawings were produced from the 590 individual measurements identified, which informed the development of a 3D digital model. A similar review of full range of motion data was conducted as a meta-analysis and the results were applied to the existing model, providing an inter-connected, articulated digital spine. During these data analysis processes several inconsistencies were observed accompanied by an evidential lack of standardization with measurement and recording of data. These have been categorized as: anatomical terminology; scaling of measurements; measurement methodology, dimension and anatomical reference positions; global coordinate systems. There is inconsistency in anatomical terminology where independent researchers use the same terms to describe different aspects of anatomy or different terms for the same anatomy. Published standards exist for measurement methods of the human body regarding spatial interaction, anthropometric databases, automotive applications, clothing industries and for computer manikins, but none exists for skeletal anatomy. Presentation of measurements often lacks formal structure in clinical publications, seldom providing geometric reference points, therefore making digital reconstruction difficult. Published quantitative data does not follow existing

  12. Including Alternative Resources in State Renewable Portfolio Standards: Current Design and Implementation Experience

    Energy Technology Data Exchange (ETDEWEB)

    Heeter, J.; Bird, L.

    2012-11-01

    Currently, 29 states, the District of Columbia, and Puerto Rico have instituted a renewable portfolio standard (RPS). An RPS sets a minimum threshold for how much renewable energy must be generated in a given year. Each state policy is unique, varying in percentage targets, timetables, and eligible resources. This paper examines state experience with implementing renewable portfolio standards that include energy efficiency, thermal resources, and non-renewable energy and explores compliance experience, costs, and how states evaluate, measure, and verify energy efficiency and convert thermal energy. It aims to gain insights from the experience of states for possible federal clean energy policy as well as to share experience and lessons for state RPS implementation.

  13. ASME nuclear codes and standards: Scope of coverage and current initiatives

    International Nuclear Information System (INIS)

    The objective of this paper is to address the broad scope of coverage of nuclear codes, standards and guides produced and administered by the American Society of Mechanical Engineers (ASME). Background information is provided regarding the evolution of the present activities. Details are provided on current initiatives intended to permit ASME to meet the needs of a changing nuclear industry on a worldwide scale. During the early years of commercial nuclear power, ASME produced a code for the construction of nuclear vessels used in the reactor coolant pressure boundary, containment and auxiliary systems. In response to industry growth, ASME Code coverage soon broadened to include rules for construction of other nuclear components, and inservice inspection of nuclear reactor coolant systems. In the years following this, the scope of ASME nuclear codes, standards and guides has been broadened significantly to include air cleaning activities for nuclear power reactors, operation and maintenance of nuclear power plants, quality assurance programs, cranes for nuclear facilities, qualification of mechanical equipment, and concrete reactor vessels and containments. ASME focuses on globalization of its codes, standards and guides by encouraging and promoting their use in the international community and by actively seeking participation of international members on its technical and supervisory committees and in accreditation activities. Details are provided on current international representation. Initiatives are underway to separate the technical requirements from administrative and enforcement requirements, to convert to hard metric units, to provide for non-U. S. materials, and to provide for translations into non-English languages. ASME activity as an accredited ISO 9000 registrar for suppliers of mechanical equipment is described. Rules are being developed for construction of containment systems for nuclear spent fuel and high-level waste transport packagings. Intensive

  14. Age of First Use as a Predictor of Current Alcohol and Marijuana Use among College-Bound Emerging Adults

    Science.gov (United States)

    Bergen-Cico, Dessa K.; Lape, Megan E.

    2013-01-01

    Background: Alcohol and marijuana are the most commonly used psychoactive substances; however, the sequencing and relationship between age of first use and continued current problematic use among college-bound emerging adults is not well understood. Methods: This is a cross-sectional study of current and historical alcohol and marijuana use among…

  15. Radiotherapy for pediatric brain tumors: Standard of care, current clinical trials, and new directions

    International Nuclear Information System (INIS)

    Objectives: To review the clinical characteristics of childhood brain tumors, including neurologic signs, neuroimaging and neuropathology. To critically assess indications for therapy relevant to presenting characteristics, age, and disease status. To discuss current management strategies including neurosurgery, radiation therapy, and chemotherapy. To analyze current clinical trials and future directions of clinical research. Brain tumors account for 20% of neoplastic diseases in children. The most common tumors include astrocytoma and malignant gliomas, medulloblastoma and supratentorial PNET's, ependymoma, craniopharyngioma, and intracranial germ cell tumors. Tumor type and clinical course are often correlated with age at presentation and anatomic site. The clinical characteristics and disease extent largely determine the relative merits of available 'standard' and investigational therapeutic approaches. Treatment outcome, including disease control and functional integrity, is dependent upon age at presentation, tumor type, and disease extent. An understanding of the clinical, neuroimaging, and histologic characteristics as they relate to decisions regarding therapy is critical to the radiation oncologist. Appropriate radiation therapy is central to curative therapy for a majority of pediatric brain tumor presentations. Technical advances in neurosurgery provide greater safety for 'gross total resection' in a majority of hemispheric astrocytomas and medulloblastomas. The relative roles of 'standard' radiation therapy and evolving chemotherapy for centrally located astrocytomas (e.g., diencephalic, optic pathway) need to be analyzed in the context of initial and overall disease control, neurotoxicities, and potential modifications in the risk:benefit ratio apparent in the introduction of precision radiation techniques. Modifications in radiation delivery are fundamental to current investigations in medulloblastoma; the rationale for contemporary and projected

  16. Comparison of measured spirometric values of nonsmoker healthy adults in Sari city with some standard predicted equations

    OpenAIRE

    R.A. Mohammadpour; S. Etemadi Nezhad; A. Alizadeh

    2006-01-01

    Background and purpose: Spirometry is a powerful method in assessment and management of many respiratory disorders. Technological improvement has made it a reliable, relatively simple and available method in clinical settings. Native spirometric standard values are necessary for the interpretation of pulmonary function test. In this study, important spirometric values (FVC,FEV1, FEV1/ FVC ,FEF25-75 ) of healthy adults > 18 years old in Sari city were compared with those of predicted standard ...

  17. Organ dose conversion coefficients for tube current modulated CT protocols for an adult population

    Science.gov (United States)

    Fu, Wanyi; Tian, Xiaoyu; Sahbaee, Pooyan; Zhang, Yakun; Segars, William Paul; Samei, Ehsan

    2016-03-01

    In computed tomography (CT), patient-specific organ dose can be estimated using pre-calculated organ dose conversion coefficients (organ dose normalized by CTDIvol, h factor) database, taking into account patient size and scan coverage. The conversion coefficients have been previously estimated for routine body protocol classes, grouped by scan coverage, across an adult population for fixed tube current modulated CT. The coefficients, however, do not include the widely utilized tube current (mA) modulation scheme, which significantly impacts organ dose. This study aims to extend the h factors and the corresponding dose length product (DLP) to create effective dose conversion coefficients (k factor) database incorporating various tube current modulation strengths. Fifty-eight extended cardiac-torso (XCAT) phantoms were included in this study representing population anatomy variation in clinical practice. Four mA profiles, representing weak to strong mA dependency on body attenuation, were generated for each phantom and protocol class. A validated Monte Carlo program was used to simulate the organ dose. The organ dose and effective dose was further normalized by CTDIvol and DLP to derive the h factors and k factors, respectively. The h factors and k factors were summarized in an exponential regression model as a function of body size. Such a population-based mathematical model can provide a comprehensive organ dose estimation given body size and CTDIvol. The model was integrated into an iPhone app XCATdose version 2, enhancing the 1st version based upon fixed tube current modulation. With the organ dose calculator, physicists, physicians, and patients can conveniently estimate organ dose.

  18. Current Status of Core and Advanced Adult Gastrointestinal Endoscopy Training in Canada: Survey of Existing Accredited Programs

    OpenAIRE

    Xiong, Xin; Barkun, Alan N; Waschke, Kevin; Martel, Myriam

    2013-01-01

    OBJECTIVE: To determine the current status of core and advanced adult gastroenterology training in Canada.METHODS: A survey consisting of 20 questions pertaining to core and advanced endoscopy training was circulated to 14 accredited adult gastroenterology residency program directors. For continuous variables, median and range were analyzed; for categorical variables, percentage and associated 95% CIs were analyzed.RESULTS: All 14 programs responded to the survey. The median number of core tr...

  19. Impacts of China's Current Appliance Standards and LabelingProgram to 2020

    Energy Technology Data Exchange (ETDEWEB)

    Fridley, David; Aden, Nathaniel; Zhou, Nan; Lin, Jiang

    2007-03-03

    The report summarizes the history and nature of China sstandardsand labeling program in the Introduction in Section 1. Trends indomestic production, exports, penetration rates, unit energy consumptionand the history of S&L technical levels by product are discussed ingreat detail in Section 2. The national energy impactsanalysis found inSection 3 concludes that overall China s standards and labeling programsreduce total electricity consumption in 2020 by an annual 106 TWh, or 16percent of what would otherwise been expected in that year in the absenceof standards and labeling programs.In total, the report concludes thatthe S&L programs currently in place in China are expected to save acumulative 1143 TWh by 2020, or 9 percent of the cumulative consumptionof residential electricity to that year. In 2020 alone, annual savingsare expected to be equivalent to 11 percent of residential electricityuse. In average generation terms, this is equivalent to 27 1-GW coalfired plants that would have required around 75 million tonnes of coal tooperate.In comparison, savings from the US appliance standards programalone is expected to save 10 percent of residential electricityconsumption in 2020.

  20. Interaction of recalled parental ADHD symptoms and rearing behavior with current attachment and emotional dysfunction in adult offspring with ADHD.

    Science.gov (United States)

    Edel, Marc-Andreas; Juckel, Georg; Brüne, Martin

    2010-06-30

    Research into attachment and emotion regulation has shown that children with ADHD are at risk of developing attachment disorders and emotion regulation disturbances, which in part may be due to the rearing style of their parents. No such data exists for adults with persistent ADHD. We hypothesized that current attachment style and emotion processing of adult patients with ADHD may be influenced by the presence of parental ADHD symptoms when the now adult patients were children, assuming that ADHD symptoms of parents have an impact on their parenting style. We examined recalled parental ADHD symptoms and rearing style as well as current attachment and emotion regulation abilities in a sample of 73 adults with ADHD using several self-rating instruments. Recalled prevalence of ADHD symptoms in the mother, and less so in the father, of adult patients with ADHD was significantly associated with partly adverse parental rearing styles, current attachment problems in romantic partnerships and emotion regulation disturbances compared with adult ADHD patients without possibly affected parent. ADHD symptoms in parents of children with ADHD may present a risk factor for attachment problems and poor emotion regulation when ADHD children are grown. PMID:20452044

  1. Recruitment Issues and Strategies for Adults Who Are Not Currently Participating in Literacy and Adult Basic Education (ABE) Programs.

    Science.gov (United States)

    Kohring, Aaron

    Adult basic education (ABE) and literacy programs have used many different strategies and tools to recruit new students. A small sampling of Tennessee ABE programs shows the more effective recruitment strategies are word-of-mouth referrals; newspaper advertisements and articles; fliers; brochures; posters, radio messages, and public service…

  2. Should Cerebral Near-infrared Spectroscopy be Standard of Care in Adult Cardiac Surgery?

    Science.gov (United States)

    Bevan, Priscilla J W

    2015-06-01

    Near-infrared spectroscopy (NIRS) is non-invasive, easy to use, and offers real-time monitoring of the oxygen content of cerebral tissue. An effective and user-friendly method of cerebral monitoring stands to offer a significant advance in patient care during adult cardiac surgery, particularly for surgery in which the continuity of cerebral vessels may be compromised. While the current evidence does not definitively show improvement in neurological outcomes, it can be argued that the overall risk to benefit ratio falls on the side of NIRS. NIRS also gives information about the oxygenation of systemic tissues. It may be that in surgery that does not involve the aortic arch, the value of NIRS will be in increased individualisation of patient management and improved systemic perfusion, impacting general outcomes as much as neurological outcomes. This review will summarise the need for neuromonitoring and the principles of NIRS. It will examine the thresholds used to define desaturation, the evidence for clinical benefit from NIRS, and the criticisms and limitations of NIRS. It will also discuss the uses of NIRS beyond improving neurological outcomes alone. PMID:25735719

  3. Standard series of direct-current motors for regulated electric drives

    Science.gov (United States)

    Cholewicki, I.; Lubina, M.; Kozhevnikov, V. A.; Kochnev, A. V.; Skoda, K.; Voleskiy, E.

    1984-11-01

    A standard series of d.c. motors for electric drives with speed and torque regulation has been developed. Thyristor-type converters for machine tools with digital program control are also being developed. Meeting future goals requires modification of the motor frame from the conventional round to a nearly square one, a larger ratio of armature stack length to diameter, better cooling, and insulation of a higher temperature class. In addition, it is necessary to laminate the housing partially or completely and to include a compensating winding. The basic motor configuration is 1 M 1001, according to Council of Mutual Economic Assistance (CEMA) Standard 246-78, with at least IP 23S protection and 1C 06 or 1C 05 cooling (shaft height from 112 mm up) and 1C 01 cooling (Shaft height or up to 250 mm). The series will be designed for a reference speed of 1500 rpm with not more than 15% armature current fluctuation, with speeds of 300-3000 rpm depending on voltage and motor size and torque regulation 1:200 (externally cooled motors) or 1;5, 1:10, 1:30 (self-cooled motors). Prototype motors with 132 mm and 355 mm shaft heights have already passed all tests.

  4. Clinical compliance of viewing conditions in radiology reporting environments against current guidelines and standards

    Science.gov (United States)

    Daly, S.; Rainford, L.; Butler, M. L.

    2014-03-01

    Several studies have demonstrated the importance of environmental conditions in the radiology reporting environment, with many indicating that incorrect parameters could lead to error and misinterpretation. Literature is available with recommendations as to the levels that should be achieved in clinical practice, but evidence of adherence to these guidelines in radiology reporting environments is absent. This study audited the reporting environments of four teleradiologist and eight hospital based radiology reporting areas. This audit aimed to quantify adherence to guidelines and identify differences in the locations with respect to layout and design, monitor distance and angle as well as the ambient factors of the reporting environments. In line with international recommendations, an audit tool was designed to enquire in relation to the layout and design of reporting environments, monitor angle and distances used by radiologists when reporting, as well as the ambient factors such as noise, light and temperature. The review of conditions were carried out by the same independent auditor for consistency. The results obtained were compared against international standards and current research. Each radiology environment was given an overall compliance score to establish whether or not their environments were in line with recommended guidelines. Poor compliance to international recommendations and standards among radiology reporting environments was identified. Teleradiology reporting environments demonstrated greater compliance than hospital environments. The findings of this study identified a need for greater awareness of environmental and perceptual issues in the clinical setting. Further work involving a larger number of clinical centres is recommended.

  5. Transcranial direct current stimulation of the primary motor cortex improves word-retrieval in older adults.

    Directory of Open Access Journals (Sweden)

    Marcus eMeinzer

    2014-09-01

    Full Text Available Language facilitation by transcranial direct current stimulation (tDCS in healthy individuals has generated hope that tDCS may also allow improving language impairment after stroke (aphasia. However, current stimulation protocols have yielded variable results and may require identification of residual language cortex using functional magnetic resonance imaging (fMRI, which complicates incorporation into clinical practice. Based on previous behavioral studies that demonstrated improved language processing by motor system pre-activation, the present study assessed whether tDCS administered to the primary motor cortex (M1 can enhance language functions.This proof-of-concept study employed a sham-tDCS controlled, cross-over, within-subject design and assessed the impact of unilateral excitatory (anodal and bihemispheric (dual tDCS in eighteen healthy older adults during semantic word-retrieval and motor speech tasks. Simultaneous fMRI scrutinized the neural mechanisms underlying tDCS effects.Both active tDCS conditions significantly improved word-retrieval compared to sham-tDCS. The direct comparison of activity elicited by word-retrieval vs. motor-speech trials revealed bilateral frontal activity increases during both anodal- and dual-tDCS compared to sham-tDCS. This effect was driven by more pronounced deactivation of frontal regions during the motor-speech task, while activity during word-retrieval trials was unaffected by the stimulation. No effects were found in M1 and secondary motor regions.Our results show that tDCS administered to M1 can improve word-retrieval in healthy individuals, thereby providing a rationale to explore whether M1-tDCS may offer a novel approach to improve language functions in aphasia. fMRI revealed neural facilitation specifically during motor speech trials, which may have reduced switching costs between the overlapping neural systems for lexical retrieval and speech processing, thereby resulting in improved

  6. Adult leukaemia: what is the role of currently known risk factors?

    International Nuclear Information System (INIS)

    Leukaemias are a heterogeneous group of tumours including acute and chronic forms. Considerable efforts have been made to identify risk factors for these diseases, but only a minority of leukaemia cases can currently be attributed to identified or hypothesized factors. This review highlights recent epidemiological literature concerning adult leukaemia, discussing in detail the hereditary, environmental and medical risks. Chromosomal syndromes and genetically based diseases carry a high risk of leukaemia, but rarely occur in the population. Environmental and occupational exposures to chemicals including pesticides have been widely studied, although the results are not consistent, with the exception of benzene. Smoking seems to be a weak causal risk factor. The risk of ionizing radiation has further been quantified in recent studies, although the effects of low doses have not yet been clarified. The results for non-ionizing radiation continue to be inconsistent, but a large effect of electromagnetic fields on the risk of leukaemia appears to be unlikely. Medically applied radio- and chemotherapy are clearly associated with subsequent leukaemia development, and there are links between leukaemia and viral infections. Future research should emphasize the shortcomings in exposure assessment that pervade many studies, and interactions between different risk factors need to be taken into consideration. (orig.)

  7. Adult leukaemia: what is the role of currently known risk factors?

    Energy Technology Data Exchange (ETDEWEB)

    Zeeb, H. [Deutsches Krebsforschungszentrum, Abt. Epidemiologie, Im Neuenheimer Feld 280, D-69120 Heidelberg (Germany); Blettner, M. [International Agency for Research on Cancer (IARC), Unit of Carcinogen Identification and Evaluation, 150 Cours Albert Thomas, F-69372 Lyon (France)

    1998-02-01

    Leukaemias are a heterogeneous group of tumours including acute and chronic forms. Considerable efforts have been made to identify risk factors for these diseases, but only a minority of leukaemia cases can currently be attributed to identified or hypothesized factors. This review highlights recent epidemiological literature concerning adult leukaemia, discussing in detail the hereditary, environmental and medical risks. Chromosomal syndromes and genetically based diseases carry a high risk of leukaemia, but rarely occur in the population. Environmental and occupational exposures to chemicals including pesticides have been widely studied, although the results are not consistent, with the exception of benzene. Smoking seems to be a weak causal risk factor. The risk of ionizing radiation has further been quantified in recent studies, although the effects of low doses have not yet been clarified. The results for non-ionizing radiation continue to be inconsistent, but a large effect of electromagnetic fields on the risk of leukaemia appears to be unlikely. Medically applied radio- and chemotherapy are clearly associated with subsequent leukaemia development, and there are links between leukaemia and viral infections. Future research should emphasize the shortcomings in exposure assessment that pervade many studies, and interactions between different risk factors need to be taken into consideration. (orig.) With 1 fig., 5 tabs., 114 refs.

  8. Childhood Trauma and Current Psychological Functioning in Adults with Social Anxiety Disorder

    OpenAIRE

    Kuo, Janice R.; Goldin, Philippe R.; Werner, Kelly; Heimberg, Richard G.; Gross, James J.

    2010-01-01

    Etiological models of social anxiety disorder (SAD) suggest that early childhood trauma contributes to the development of this disorder. However, surprisingly little is known about the link between different forms of childhood trauma and adult clinical symptoms in SAD. This study (1) compared levels of childhood trauma in adults with generalized SAD versus healthy controls (HCs), and (2) examined the relationship between specific types of childhood trauma and adult clinical symptoms in SAD. P...

  9. The conformal anomaly and the neutral currents sector of the Standard Model

    International Nuclear Information System (INIS)

    We elaborate on the structure of the graviton-gauge-gauge vertex in the electroweak theory, obtained by the insertion of the complete energy-momentum tensor (T) on 2-point functions of neutral gauge currents (VV'). The vertex defines the leading contribution to the effective action which accounts for the conformal anomaly and related interaction between the Standard Model and gravity. The energy-momentum tensor is derived from the curved spacetime Lagrangian in the linearized gravitational limit, and with the inclusion of the term of improvement of a conformally coupled Higgs sector. As in the previous cases of QED and QCD, we find that the conformal anomaly induces an effective massless scalar interaction between gravity and the neutral currents in each gauge invariant component of the vertex. This is described by the exchange of an anomaly pole. We show that for a spontaneously broken theory the anomaly can be entirely attributed to the poles only for a conformally coupled Higgs scalar. In the exchange of a graviton, the trace part of the corresponding interaction can be interpreted as due to an effective dilaton, using a local version of the effective action. We discuss the implications of the anomalous Ward identity for the TVV' correlator for the structure of the gauge/gauge/effective dilaton vertex in the effective action. The analogy between these effective interactions and those related to the radion in theories with large extra dimensions is pointed out.

  10. 78 FR 46589 - Solicitation of Written Comments on the Draft Report of the National Adult Immunization Standards...

    Science.gov (United States)

    2013-08-01

    ... U.S. Code 300aa-5 (PDF-78 KB)). Its purpose is to advise and make recommendations to ] the Director... Director of the National Vaccine Program. The ASH has charged the NVAC with examining the current adult.... Department of Health and Human Services, 200 Independence Ave. SW., Room 745.H.5, Washington, DC...

  11. Short-circuit current calculation: A comparison between methods of IEC and ANSI standards using dynamic simulation as reference

    Energy Technology Data Exchange (ETDEWEB)

    Berizzi, A.; Silvestri, A.; Zaninelli, D. (Politecnico di Milano (Italy). Dipartimento di Elettrotecnica); Massucco, S. (Univ. di Pavia (Italy). Dipartimento di Ingegneria Elettrica)

    An essential issue concerning short-circuit studies is about how precise should short-circuit calculations be. Simplified procedures have been proposed for many years by International Committees to provide reference methods for the manual computation and for the use of rated, rather than operating, equipment data. Recently, dynamic programs have been used to accurately simulate short-circuit currents. Two widely adopted international standards (ANSI/IEEE C37.010.1979 and IEC 909 Standards) are investigated in this paper for comparing and pointing out the most significant differences in methodologies, assumptions, computed currents, and results. An outline of the two standards is presented and a detailed comparison is carried on. The procedures of the two standards are applied to a test network proposed in the IEC 909 Standard. Results of calculations by the two standards are compared using the results of a transient study performed by the EMTP simulation program as a reference basis.

  12. Revision of the Euratom basic safety standards directive-current status

    International Nuclear Information System (INIS)

    The European Commission is currently developing a revised Euratom Basic Safety Standards (BSS) Directive covering two major objectives: the consolidation of existing Euratom Radiation Protection legislation and the revision of the Euratom BSS. The consolidation will merge the following five Directives into one single Directive: the BSS Directive, the Medical Exposures Directive, the Public Information Directive, the Outside Workers Directive and the Directive on the Control of high-activity sealed radioactive sources and orphan sources. The revision of the Euratom BSS will take account of the latest recommendations by the International Commission on Radiological Protection and shall improve clarity of the requirements where appropriate. It is planned to introduce more binding requirements on natural radiation sources, on criteria for exemption and clearance, and on the cooperation between Member States for emergency planning and response. The provisions for regulatory control of planned exposure situations foresee a graded approach commensurate to the magnitude and likelihood of exposures from a practice. Finally, the new BSS shall take account of recent scientific developments. One additional goal is to achieve greater harmonisation between the Euratom BSS and the international BSS. While the requirements on the protection of workers, apprentices and students remain nearly unchanged, the revised BSS will clarify the roles and responsibilities of services and experts involved in technical and practical aspects of radiation protection, such as the occupational health services, the dosimetry services, the radiation protection expert and the medical physics expert. The requirements in the BSS on individual monitoring of category A workers remain unchanged, but the existing guidance on individual monitoring was revised and updated-the technical recommendations for monitoring individuals occupationally exposed to external radiation are published by the European

  13. Computational dosimetry for child and adult human models due to contact current from 10 Hz to 110 MHz

    International Nuclear Information System (INIS)

    This study computationally investigates in situ electric field due to low-frequency contact current and specific absorption rate (SAR) due to high-frequency contact currents in a realistic child model and compared with those in the adult model. The in situ electric fields and SAR in the child model are found to exceed the corresponding values in the adult. At the finger tip, the electric field and SAR due to contact currents, both at the ICNIRP reference levels and IEEE Maximum Permissible Exposures, are well beyond the corresponding basic restrictions. In the remaining part, the largest difference was observed in spinal tissue, and the smallest effect was in the heart. With respect to brain and skin conductivities, one needs to strongly consider which values of tissue properties are used to interpret one's results. The in situ electric fields resulting from contact with the metal plane are similar to those for contact with the wire. (authors)

  14. XBRL Standard for Financial Reporting in Croatia: Current State and Perspectives

    Directory of Open Access Journals (Sweden)

    Gostimir Dejan

    2015-09-01

    Full Text Available Background: Harmonization and standardization is becoming important among regulators and business community. XBRL has entered the global stage as a financial reporting standard. Its mission was to standardize the financial reporting, lower the reporting costs and make the reporting as transparent as possible.

  15. Effects of transcranial direct current stimulation on the control of finger force during dexterous manipulation in healthy older adults.

    Directory of Open Access Journals (Sweden)

    Pranav J Parikh

    Full Text Available The contribution of poor finger force control to age-related decline in manual dexterity is above and beyond ubiquitous behavioral slowing. Altered control of the finger forces can impart unwanted torque on the object affecting its orientation, thus impairing manual performance. Anodal transcranial direct current stimulation (tDCS over primary motor cortex (M1 has been shown to improve the performance speed on manual tasks in older adults. However, the effects of anodal tDCS over M1 on the finger force control during object manipulation in older adults remain to be fully explored. Here we determined the effects of anodal tDCS over M1 on the control of grip force in older adults while they manipulated an object with an uncertain mechanical property. Eight healthy older adults were instructed to grip and lift an object whose contact surfaces were unexpectedly made more or less slippery across trials using acetate and sandpaper surfaces, respectively. Subjects performed this task before and after receiving anodal or sham tDCS over M1 on two separate sessions using a cross-over design. We found that older adults used significantly lower grip force following anodal tDCS compared to sham tDCS. Friction measured at the finger-object interface remained invariant after anodal and sham tDCS. These findings suggest that anodal tDCS over M1 improved the control of grip force during object manipulation in healthy older adults. Although the cortical networks for representing objects and manipulative actions are complex, the reduction in grip force following anodal tDCS over M1 might be due to a cortical excitation yielding improved processing of object-specific sensory information and its integration with the motor commands for production of manipulative forces. Our findings indicate that tDCS has a potential to improve the control of finger force during dexterous manipulation in older adults.

  16. Standard methods for maintaining adult Apis mellifera in cages under in vitro laboratory conditions

    NARCIS (Netherlands)

    Williams, G.R.; Alaux, C.; Costa, C.; Csaki, C.; Steen, van der J.J.M.

    2013-01-01

    Adult honey bees are maintained in vitro in laboratory cages for a variety of purposes. For example, researchers may wish to perform experiments on honey bees caged individually or in groups to study aspects of parasitology, toxicology, or physiology under highly controlled conditions, or they may c

  17. Calculation of Initial Short-Circuit Currents in Medium Voltage Networks According to the Standard PN-EN 60909

    OpenAIRE

    Krzysztof Księżyk; Tomasz Zdun

    2013-01-01

    Determining the short-circuit currents is usually conducted by network analyses. An important feature of this calculation is carried out according to the recommendations of the standard PN EN 60909. This paper describes the models of the basic elements of the network with the method of determining the impedance parameters including correction factors introduced by the standard. Thevenin’s method connected with the nodal method are presented and used to determine the initial short-circuit f...

  18. Literacy, Numeracy, and Problem Solving in Technology-Rich Environments among U.S. Adults: Results from the Program for the International Assessment of Adult Competencies 2012. Appendix D: Standard Error Tables. First Look. NCES 2014-008

    Science.gov (United States)

    National Center for Education Statistics, 2013

    2013-01-01

    This paper provides Appendix D, Standard Error tables, for the full report, entitled. "Literacy, Numeracy, and Problem Solving in Technology-Rich Environments among U.S. Adults: Results from the Program for the International Assessment of Adult Competencies 2012. First Look. NCES 2014-008." The full report presents results of the Program for the…

  19. Premarital Sexual Attitudes and Behavior of Adolescents and Young Adults: A Review of Current Literature.

    Science.gov (United States)

    Turnquist, Bruce Eric

    This document reviews research concerning the factors affecting premarital sexual attitudes and behaviors of adolescents and young adults. Trends in the literature prior to 1980 are discussed briefly together with summaries of literature reviews from the decades of the 1950s, 1960s, and 1970s. Studies from 1980 to the present are reviewed in some…

  20. NODC Standard Product: Ocean current drifter data (2 disc set) (NODC Accession 0098060)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — These CD-ROMs hold over 4 million surface current observations, almost all obtained by the ship drift method. Date, data source, position, and current direction and...

  1. Institutional abuse of children in the Austrian Catholic Church: types of abuse and impact on adult survivors' current mental health.

    Science.gov (United States)

    Lueger-Schuster, Brigitte; Kantor, Viktoria; Weindl, Dina; Knefel, Matthias; Moy, Yvonne; Butollo, Asisa; Jagsch, Reinhold; Glück, Tobias

    2014-01-01

    The aim of this study was to explore the nature and dimensions of institutional child abuse (IA) by the Austrian Catholic Church and to investigate the current mental health of adult survivors. Data were collected in two steps. First, documents of 448 adult survivors of IA (M=55.1 years, 75.7% men) who had disclosed their abuse history to a victim protection commission were collected. Different types of abuse, perpetrator characteristics, and family related risk factors were investigated. Second, a sample of 185 adult survivors completed the Posttraumatic Stress Disorder Checklist (PCL-C) and the Brief Symptom Inventory (BSI). Participants reported an enormous diversity of acts of violent physical, sexual, and emotional abuse that had occurred in their childhood. The majority of adult survivors (83.3%) experienced emotional abuse. Rates of sexual (68.8%) and physical abuse (68.3%) were almost equally high. The prevalence of PTSD was 48.6% and 84.9% showed clinically relevant symptoms in at least one 1 of 10 symptom dimensions (9 BSI subscales and PTSD). No specific pre-IA influence was found to influence the development of PTSD in later life (e.g. poverty, domestic violence). However, survivors with PTSD reported a significantly higher total number of family related risk factors (d=0.33). We conclude that childhood IA includes a wide spectrum of violent acts, and has a massive negative impact on the current mental health of adult survivors. We address the long-term effects of these traumatic experiences in addition to trauma re-activation in adulthood as both bear great challenges for professionals working with survivors. PMID:24018068

  2. Current Climate Data Set Documentation Standards: Somewhere between Anagrams and Full Disclosure

    Science.gov (United States)

    Fleig, A. J.

    2008-12-01

    techniques are being developed that will simplify the creation of much of the provenance information but there are both cultural and infrastructure problems that discourage provision of complete documentation. It is time to reconsider what the standards for production and documentation of data sets should be. There is only a short window before the loss of knowledge about current data sets associated with human mortality becomes irreversible. .

  3. Comparison of measured spirometric values of nonsmoker healthy adults in Sari city with some standard predicted equations

    Directory of Open Access Journals (Sweden)

    R.A. Mohammadpour

    2006-01-01

    Full Text Available Background and purpose: Spirometry is a powerful method in assessment and management of many respiratory disorders. Technological improvement has made it a reliable, relatively simple and available method in clinical settings. Native spirometric standard values are necessary for the interpretation of pulmonary function test. In this study, important spirometric values (FVC,FEV1, FEV1/ FVC ,FEF25-75 of healthy adults > 18 years old in Sari city were compared with those of predicted standard equations to determine the nearest values.Materials and Methods: Five hundred and seven healthy adults (245 males, 262 females selected by random sampling, with no previous history of smoking and without chronic or acute respiratory problems were subjected to spirometry with calibrated Fukudo Sangyo spirometer. The methodological guidelines of the American Thorasic Society were observed to perform spirometry. The results were analyzed by SPSS, paired t- test and Pearson correlation.Results: The results indicated that the mean values of males are more than those of females .The highest values are from the 20-30 years age group.The correlation coefficient of height with the measured values is very high (99% confidence interval but for the weight is low. The nearest standard predicted values to the measured values were from Eccs.Conclusion: According to the results and correlation coefficient test, measured values have the highest correlation with Eccs predicted values with 99% confidence interval and the Eccs standard seems to be the most proper standard for Sari community, more researches are recommended though.

  4. Treatment of a giant congenital melanocytic nevus in the adult: review of the current management of giant congenital melanocytic nevus.

    Science.gov (United States)

    Su, Jeannie J; Chang, Daniel K; Mailey, Brian; Gosman, Amanda

    2015-05-01

    Giant congenital melanocytic nevi (GCMNs) create cosmetic disfigurements and pose risk for malignant transformation. Adult GCMN cases are uncommon because most families opt for surgical treatment during childhood. We review the current literature on GCMN and present an interesting case of an adult with a GCMN encompassing the entire back with painful nodules exhibiting gross involvement of his back musculature, without pathologic evidence of malignancy. Surgical management was deferred in childhood because of parental desires to allow the patient to make his own decision, and treatment in adulthood was pursued on the basis of the significant impairment of the patient's quality of life and self-esteem due to the massive size and deforming nature of the nevus. The treatment strategy used for this young adult male patient involved a massive en bloc excision of the GCMN with partial resection of the latissimus dorsi, followed by a 5-week staged reconstructive process using dermal regenerative matrices and split-thickness skin grafting. Because of the shift in GCMN management from early surgical management to more conservative management, we may see an increase in adult cases of GCMN. Thus, it is critical to better understand the controversy surrounding early versus delayed management of GCMN. PMID:25664413

  5. Older Adults' Current and Potential Uses of Information Technologies in a Changing World: A Theoretical Perspective.

    Science.gov (United States)

    Backonja, Uba; Hall, Amanda K; Thielke, Stephen

    2014-12-01

    Technologies have become a major force in people's lives. They change how people interact with the environment, even as the environment changes. We propose that technology use in the setting of changing environments is motivated by essential needs and tensions experienced by the individual. We apply three developmental and behavioral theories (Erikson's stages of psychosocial development, Maslow's hierarchy of needs, and Bronfenbrenner's ecological model) to explain technology-related behaviors among older adults. We consider how technology use has addressed and can address major ecological changes, in three areas: health promotion, natural disasters, and disparities. We propose that considering these theories can help researchers and developers ensure that technologies will help promote a healthier world for older adults. PMID:26215298

  6. Adult stem cells in neural repair: Current options,limitations and perspectives

    Institute of Scientific and Technical Information of China (English)

    Eric Domingos Mariano; Manoel Jacobsen Teixeira; Suely Kazue Nagahashi Marie; Guilherme Lepski

    2015-01-01

    Stem cells represent a promising step for the future ofregenerative medicine. As they are able to differentiateinto any cell type, tissue or organ, these cells are greatcandidates for treatments against the worst diseasesthat defy doctors and researchers around the world.Stem cells can be divided into three main groups (1)embryonic stem cells; (2) fetal stem cells; and (3) adultstem cells. In terms of their capacity for proliferation,stem cells are also classified as totipotent, pluripotentor multipotent. Adult stem cells, also known as somaticcells, are found in various regions of the adult organism,such as bone marrow, skin, eyes, viscera and brain.They can differentiate into unipotent cells of theresiding tissue, generally for the purpose of repair.These cells represent an excellent choice in regenerativemedicine, every patient can be a donor of adult stemcells to provide a more customized and efficient therapyagainst various diseases, in other words, they allow theopportunity of autologous transplantation. But in orderto start clinical trials and achieve great results, we needto understand how these cells interact with the hosttissue, how they can manipulate or be manipulated bythe microenvironment where they will be transplantedand for how long they can maintain their multipotentstate to provide a full regeneration.

  7. Adult subependymal neural precursors, but not differentiated cells, undergo rapid cathodal migration in the presence of direct current electric fields.

    Directory of Open Access Journals (Sweden)

    Robart Babona-Pilipos

    Full Text Available BACKGROUND: The existence of neural stem and progenitor cells (together termed neural precursor cells in the adult mammalian brain has sparked great interest in utilizing these cells for regenerative medicine strategies. Endogenous neural precursors within the adult forebrain subependyma can be activated following injury, resulting in their proliferation and migration toward lesion sites where they differentiate into neural cells. The administration of growth factors and immunomodulatory agents following injury augments this activation and has been shown to result in behavioural functional recovery following stroke. METHODS AND FINDINGS: With the goal of enhancing neural precursor migration to facilitate the repair process we report that externally applied direct current electric fields induce rapid and directed cathodal migration of pure populations of undifferentiated adult subependyma-derived neural precursors. Using time-lapse imaging microscopy in vitro we performed an extensive single-cell kinematic analysis demonstrating that this galvanotactic phenomenon is a feature of undifferentiated precursors, and not differentiated phenotypes. Moreover, we have shown that the migratory response of the neural precursors is a direct effect of the electric field and not due to chemotactic gradients. We also identified that epidermal growth factor receptor (EGFR signaling plays a role in the galvanotactic response as blocking EGFR significantly attenuates the migratory behaviour. CONCLUSIONS: These findings suggest direct current electric fields may be implemented in endogenous repair paradigms to promote migration and tissue repair following neurotrauma.

  8. Historical Development of NATO Stanag 6001 Language Standards and Common European Framework (CEF) and the Comparison of Their Current Status

    Science.gov (United States)

    Solak, Ekrem

    2011-01-01

    The aim of the article is to shed light on the historical development of language studies in military and social context and to compare the current status of NATO Stanag (Standard Agreement) 6001 language scale with Common European Framework (CEF). Language studies in military context date back to World War II and the emergence of Army Specialized…

  9. The impact of self-reported life stress on current impulsivity in cocaine dependent adults

    OpenAIRE

    Ross, Elizabeth L.; Yoon, Jin H.; Mahoney, James J.; Omar, Yasmine; Newton, Thomas F.; De La Garza, Richard

    2013-01-01

    Current cocaine treatments may be enhanced with a better understanding of the underlying mechanisms that contribute to the onset and maintenance of the disease, such as life stress and impulsivity. Life stress and impulsivity have previously been studied independently as contributors to drug use, and the current study expands upon past research by examining how these factors interact with one another. The aim of the current study was to evaluate the role of life stress in predicting impulsivi...

  10. Application of Pulsed Eddy Current for Depth Measurement of Steam Generator's Wear scar tube standard

    International Nuclear Information System (INIS)

    The integrity of stem generator tube in nuclear power plant is the critical problem but the particular area on the stem generator tube could be worn away by inside impurities, fluid flow and vibration from the outside environment. At the present, the inspection of stem generator tube has been performed by using a conventional eddy current testing. Although the conventional eddy current testing is a powerful method to detect flaws of tube in online processing, it is difficult to measure the deep depth differences of the tube. Because eddy current density has changed its magnitude with distance from the surface. Whereas, the pulsed eddy current technique has been widely employed for deep depth inspection of structures such as plate, tubes. For more effective inspection, the pulsed eddy current system is enveloped to control a depth difference and submitted the multi-pointing method to select a criteria which could be obtained depth differences by the period of resistivity on the pulsed eddy current transient signals. In this paper, we used the pulsed eddy current technique to improve the capability of depth difference measurement and studied multi-pointing method to evaluate the thickness with variation of resistivity.

  11. The Immunodominant Brugia malayi Paramyosin as a Marker of Current Infection with Wuchereria bancrofti Adult Worms

    OpenAIRE

    Langy, Sandra; Plichart, Catherine; Luquiaud, Patrick; Williams, Steven A.; Nicolas, Luc

    1998-01-01

    The full-length cDNA sequence encoding Brugia malayi L3 paramyosin has been isolated by immunoscreening a cDNA library with a mouse antiserum raised against Wuchereria bancrofti L3 infective larvae. A recombinant truncated form of paramyosin was expressed as a glutathione S-transferase fusion protein and used to evaluate humoral responses of adults from a W. bancrofti-endemic area in French Polynesia according to their parasitological status. Immunoglobulin G4 (IgG4) preferentially bound to p...

  12. Comparison of current practices of cardiopulmonary perfusion technology in Iran with American Society of Extracorporeal Technology’s standards

    Science.gov (United States)

    Faravan, Amir; Mohammadi, Nooredin; Alizadeh Ghavidel, Alireza; Toutounchi, Mohammad Zia; Ghanbari, Ameneh; Mazloomi, Mehran

    2016-01-01

    Introduction: Standards have a significant role in showing the minimum level of optimal optimum and the expected performance. Since the perfusion technology staffs play an the leading role in providing the quality services to the patients undergoing open heart surgery with cardiopulmonary bypass machine, this study aimed to assess the standards on how Iranian perfusion technology staffs evaluate and manage the patients during the cardiopulmonary bypass process and compare their practice with the recommended standards by American Society of Extracorporeal Technology. Methods: In this descriptive study, data was collected from 48 Iranian public hospitals and educational health centers through a researcher-created questionnaire. The data collection questionnaire assessed the standards which are recommended by American Society of Extracorporeal Technology. Results: Findings showed that appropriate measurements were carried out by the perfusion technology staffs to prevent the hemodilution and avoid the blood transfusion and unnecessary blood products, determine the initial dose of heparin based on one of the proposed methods, monitor the anticoagulants based on ACT measurement, and determine the additional doses of heparin during the cardiopulmonary bypass based on ACT or protamine titration. It was done only in 4.2% of hospitals and health centers. Conclusion: Current practices of cardiopulmonary perfusion technology in Iran are inappropriate based on the standards of American Society of Cardiovascular Perfusion. This represents the necessity of authorities’ attention to the validation programs and development of the caring standards on one hand and continuous assessment of using these standards on the other hand. PMID:27489600

  13. Do currently available blood glucose monitors meet regulatory standards? 1-day public meeting in Arlington, Virginia.

    Science.gov (United States)

    Klonoff, David C; Reyes, Juliet S

    2013-07-01

    Blood glucose monitors (BGMs) are approved by regulatory agencies based on their performance during strict testing conducted by their manufacturers. However, after approval, there is uncertainty whether BGMs maintain the accuracy levels that were achieved in the initial data. The availability of inaccurate BGM systems pose a public health problem because their readings serve as a basis for treatment decisions that can be incorrect. Several articles have concluded that BGMs in the marketplace may not consistently provide accurate results in accordance with the regulatory standards that led to approval. To address this growing concern, Diabetes Technology Society organized and conducted a 1-day public meeting on May 21, 2013, in Arlington, VA, presided by its president, David Klonoff, M.D., FACP, Fellow AIMBE, to determine whether BGMs on the market meet regulatory standards. The meeting consisted of four sessions in which Food and Drug Administration diabetes experts as well as leading academic clinicians and clinical chemists participated: (1) How is BGM performance determined? (2) Do approved BGMs perform according to International Organization for Standardization standards? (3) How do approved BGMs perform when used by patients and health care professionals? (4) What could be the consequence of poor BGM performance? PMID:23911191

  14. Current practices and challenges in the standardization and harmonization of clinical laboratory tests.

    Science.gov (United States)

    Vesper, Hubert W; Myers, Gary L; Miller, W Greg

    2016-09-01

    Effective patient care, clinical research, and public health efforts require comparability of laboratory results independent of time, place, and measurement procedure. Comparability is achieved by establishing metrological traceability, which ensures that measurement procedures measure the same quantity and that the calibration of measurement procedures is traceable to a common reference system consisting of reference methods and materials. Whereas standardization ensures traceability to the International System of Units, harmonization ensures traceability to a reference system agreed on by convention. This article provides an overview of standardization and harmonization with an emphasis on commutability as an important variable that affects testing accuracy. Commutability of reference materials is required to ensure that traceability is established appropriately and that laboratory results are comparable. The use of noncommutable reference materials leads to inaccurate results. Whereas procedures and protocols for standardizing measurements are established and have been successfully applied in efforts such as the Hormones Standardization Program of the CDC, harmonization activities require new, more complex procedures and approaches. The American Association for Clinical Chemistry, together with its domestic and international partners, formed the International Consortium for Harmonization of Clinical Laboratory Results to coordinate harmonization efforts. Reference systems, as well as procedures and protocols to establish traceability of clinical laboratory tests, have been established and continue to be developed by national and international groups and organizations. Serum tests of thyroid function, including those for the thyroid hormones thyroxine and triiodothyronine, are among the clinical procedures for which standardization efforts are well under way. Approaches to the harmonization of measurement procedures for serum concentrations of thyroid

  15. Current Challenges in Home Nutrition Services for Frail Older Adults in Japan—A Qualitative Research Study from the Point of View of Care Managers

    OpenAIRE

    Yoshihisa Hirakawa; Takaya Kimata; Kazumasa Uemura

    2013-01-01

    Preventive care for frail older adults includes providing tailor-made diet information suited to their health conditions. The present study aims to explore the current situation and challenges of home nutrition advice for Japanese frail older adults using qualitative data from a ten-person group discussion among care managers. As the results of our analysis, nine themes were identified: (1) Homebound older adults develop poor eating habits; meals turn into a lonely and unpleasant experience; ...

  16. Life regrets and pride among low-income older adults: relationships with depressive symptoms, current life stressors and coping resources.

    Science.gov (United States)

    Choi, Namkee G; Jun, Jina

    2009-03-01

    We examined the contents and intensities of both life regrets and pride among a convenience sample of 213 low-income older adults and the associations between the contents and intensities of life regrets and pride, on the one hand, and the older adults' current life stressors, coping resources and depressive symptoms, on the other. Regrets about education, career and marriage were common, but intensities of regrets were higher for issues related to finance/money, family conflict and children's problems, loss and grief, and health. Common sources of pride were related to children and parenting, career, volunteering/informal caregiving, long/strong marriage and personal growth/self. Controlling for current life stressors of disability, money worries, loneliness and overdependence on others for management of daily life, and coping resources of social support and religiosity, the intensities of loss-and-grief related regrets and the pride in long/strong marriage were significant predictors of the Geriatric Depression Scale (GDS) scores. However, the regrets and pride explained a small amount of the variance in the GDS scores, while the current life stressors explained a large portion of the variance. PMID:19347688

  17. Radiotherapy for pediatric brain tumors: Standards of care, current clinical trials, and new directions

    International Nuclear Information System (INIS)

    The objectives of the course are to evaluate the role of radiation therapy in the treatment of pediatric brain tumors. Areas where the role is evolving will be identified, and the results of clinical trials which been mounted to clarify radiotherapy's role will be reviewed. Brain tumors are the second most common malignancy of childhood after leukemias and lymphomas. However, they remain the most common group of childhood tumors to require radiation therapy. Therefore, a thorough understanding of these tumors, and the appropriate role of surgery, radiation and chemotherapy is critical. Issues surrounding the management of sequelae are no less important. The role of radiotherapy for the treatment of these tumors is far different from that for adults. These differences relate to the profound potential for sequelae from therapy, the higher overall cure rates, and the utility of multimodality therapies. In addition, the rarity of childhood brain tumors compared with adults' makes them more difficult to study. In this session, the following issues will be reviewed; 1. Incidence of pediatric brain tumors, 2. General issues regarding symptoms, diagnosis, diagnostic tests and evaluation, 3. Importance of a team approach, 4. General issues regarding treatment sequelae, 5. Specific tumor types/entities; a. Cerebellar Astrocytomas b. Benign and malignant Gliomas including brainstem and chiasmatic lesions c. Primitive Neuroectodermal Tumors (PNET) and Medulloblastoma d. Ependymomas e. Craniopharyngiomas f. Germ cell tumors g. Miscellaneous and rare pediatric brain tumors 6. Management of sequelae 7. New and future directions a. Treatment of infants b. The expanding role of chemotherapy c. Advances in radiotherapy. The attendees will complete the course with a better understanding of the role that radiation therapy plays in the treatment of pediatric brain tumors. They will be knowledgeable in the foundation for that role, and the changes which are likely to take place in the

  18. The development and standardization of the Adult Developmental Co-ordination Disorders/Dyspraxia Checklist (ADC).

    Science.gov (United States)

    Kirby, Amanda; Edwards, Lisa; Sugden, David; Rosenblum, Sara

    2010-01-01

    Developmental Co-ordination Disorder (DCD), also known as Dyspraxia in the United Kingdom (U.K.), is a developmental disorder affecting motor co-ordination. In the past this was regarded as a childhood disorder, however there is increasing evidence that a significant number of children will continue to have persistent difficulties into adulthood. Despite this, there remains little information as to how the difficulties might present at this stage, and additionally the impact on every day functioning. As young people move into further and higher education there is a need for screening and assessment tools. Such tools allow for identification of these difficulties, access to support, and clarification of areas where appropriate support needs to be targeted. This paper describes the first adult screening tool for DCD. The development and the results from testing this tool in two countries, Israel and the U.K. are outlined and the implications for its use in further and higher education discussed. PMID:19819107

  19. Calculation of Initial Short-Circuit Currents in Medium Voltage Networks According to the Standard PN-EN 60909

    Directory of Open Access Journals (Sweden)

    Krzysztof Księżyk

    2013-12-01

    Full Text Available Determining the short-circuit currents is usually conducted by network analyses. An important feature of this calculation is carried out according to the recommendations of the standard PN EN 60909. This paper describes the models of the basic elements of the network with the method of determining the impedance parameters including correction factors introduced by the standard. Thevenin’s method connected with the nodal method are presented and used to determine the initial short-circuit for the example medium voltage network. Results are compared with the ones obtained without taking into account the correction factors.

  20. Current considerations related to physiological differences between the sexes and physical employment standards.

    Science.gov (United States)

    Roberts, Delia; Gebhardt, Deborah L; Gaskill, Steven E; Roy, Tanja C; Sharp, Marilyn A

    2016-06-01

    The use of physical employment standards (PES) has helped ensure that workers have the physical attributes necessary to complete their jobs in a safe and efficient manner. However, PES used in the selection processes have not always reflected the critical physical requirements of the job tasks. Women generally have smaller anthropometric stature than men, less muscle mass, and therefore less strength, power, and endurance, particularly in the upper body. Nonetheless, these attributes in themselves are not valid grounds for exclusion from employment in physically demanding occupations. Selection standards based upon size or strength, irrespective of the job requirements, have resulted in the barring of capable women from physically demanding jobs, claims of gender bias, and costly litigations. To ensure all individuals are provided with equal access to employment, accurate characterization of the critical physical requirements of the job is paramount. This paper summarizes the existing research related to disparities between the sexes that contribute to sex differences in job performance in physically demanding occupations including physical and legal factors. Strategies for mitigating these differences in the setting of PES and the meeting of minimum employment standards are discussed. Where available, injury rates for women and men in physically demanding occupations are presented and the etiology considered. Finally, areas for further research are identified. PMID:27277561

  1. Concept of loneliness, and perception of their current life moment, among elderly adults from Bello, Colombia, 2007

    Directory of Open Access Journals (Sweden)

    Jairo L. Cardona J

    2009-08-01

    Full Text Available Objective: To explore the concept of loneliness and perception of the moment experienced by adults 55 and older in the municipality of Bello (Antioquia in 2007. Methodology: A cross-sectional study. Two were open-ended questions were coded and were crossed with socio-demographic variables. The convenience sample was comprised of 180 adults of both sexes, residents in the municipality of Bello (Antioquia and were not institutionalized. Results: The predominant concepts of loneliness were “being alone” (42.7%, “feeling lonely” (23%, followed by “horrible” (13.5% and “isolated” (7.5%, and other concepts (12.5% emphasized that the concept of loneliness is associated with socio-economic stratum and educational level attained. Conclusions: The survey population is predominant in a more objective (alone than subjective (feeling alone of loneliness. The way to perceive the current stage of life has a close relationship with the concept of loneliness, those who perceive it in a positive way choose preferably objectives concepts of loneliness. Despite the major changes experienced by older adults and the crises that must pass through this life cycle, it is generally perceived that they feel comfortable with the moment of their existence.

  2. International standard of radiation sterilization current trend of dose setting and the issues

    Energy Technology Data Exchange (ETDEWEB)

    Takehisa, Masaaki [Radia Industry Co. Ltd., Takasaki, Gunma (Japan)

    1995-03-01

    Current devices produced in a clean environment have low bioburden. However, a sensitivity of verification test of ISO method 1 declines at a low bioburden. Validation of the verification test in low bioburden region should be studied further. A dose setting using D{sub 10} of bioburden isolate should be reevaluated and be included in the ISO dose setting method. (author).

  3. International standard of radiation sterilization current trend of dose setting and the issues

    International Nuclear Information System (INIS)

    Current devices produced in a clean environment have low bioburden. However, a sensitivity of verification test of ISO method 1 declines at a low bioburden. Validation of the verification test in low bioburden region should be studied further. A dose setting using D10 of bioburden isolate should be reevaluated and be included in the ISO dose setting method. (author)

  4. Standardization of calibration of clinic dosemeters using electric currents and charges

    International Nuclear Information System (INIS)

    Clinical dosimeters used in radiotherapy are calibrated in Latin American countries, including Brazil, as a complete 'system, i.e., ionization chamber and electrometer together. Some countries, as European ones, and USA calibrate them by component, i.e., ionisation chamber apart from electrometer. This method is more advantageous than the previous one, since it makes possible the automation of the calibration process, allowing the acquisition of data related to the chamber and the electrometer measurements independently, as well as the substitution of one of the components, in case of failure. This work proposes a method for standardisation of low intensity electric charge and currents in order to implement electric calibration of electrometers. This will make possible the implementation of a by components calibration technique, by components, of clinical dosimeters in Brazil. The results obtained with the calibration by components prove that the proposed method of standardisation of low electric charges and currents is viable. The difficulties found for the generation and measurement of low intensity electric charges and currents and the procedures adopted for the calibration by components are presented. Additionally, a current source was built to yield reference electric charges that will make possible the quality control clinical dosimeters. This source will also allow the user to identify the defective components of the dosimeters, through a simple verification test. (author)

  5. Does SMS Text Messaging Help or Harm Adults' Knowledge of Standard Spelling?

    Science.gov (United States)

    Powell, D.; Dixon, M.

    2011-01-01

    The recent increase in short messaging system (SMS) text messaging, often using abbreviated, non-conventional "textisms" (e.g. "2nite"), in school-aged children has raised fears of negative consequences of such technology for literacy. The current research used a paradigm developed by Dixon and Kaminska, who showed that exposure to phonetically…

  6. Toward the use of a standardized assessment for young children with autism: current assessment practices in the UK.

    Science.gov (United States)

    Martin, Neil T; Bibby, Peter; Mudford, Oliver C; Eikeseth, Svein

    2003-09-01

    Little is known about the progress of autistic children following specific interventions in England. Nor do we know how frequently standardized assessments are used to monitor progress or to evaluate specific educational interventions. The reports of 75 children with autism, for whom special educational provision had been determined by a local education authority, were reviewed. Parents were interviewed and educational psychologists were contacted for details of any norm-referenced assessments. Of these children, 39 percent had no standardized assessments before education authorities determined their provision, and only 9 percent had follow-up assessments that could be used to evaluate progress. Children with autism in the UK rarely have sufficient assessments to allow an objective evaluation of their progress. There is currently no standardized assessment protocol to prescribe a specific educational intervention, to evaluate the progress of children or to make comparisons between interventions. We recommend the development of such a protocol. PMID:14516063

  7. Numerically simulated cardiac exposure to electric current densities induced by TASER X-26 pulses in adult men

    Science.gov (United States)

    Leitgeb, N.; Niedermayr, F.; Neubauer, R.; Loos, G.

    2010-10-01

    There is still an ongoing debate whether or not electronic stun devices (ESDs) induce cardiac fibrillation. To assess the ventricular fibrillation risk of law enforcing electronic control devices, quantitative estimates of cardiac electric current densities induced by delivered electric pulses are essential. Numerical simulations were performed with the finite integration technique and the anatomical model of a standardized European man (NORMAN) segmented into 2 mm voxels and 35 different tissues. The load-dependent delivery of TASER X-26 pulses has been taken into account. Cardiac exposure to electric current densities of vertically and horizontally aligned dart electrodes was quantified and different hit scenarios compared. Since fibrillation thresholds critically depend on exposed volume, the provided quantitative data are essential for risk assessment. The maximum cardiac rms current densities amounted to 7730 A m-2. Such high current densities and exposed cardiac volumes do not exclude ventricular fibrillation.

  8. Numerically simulated cardiac exposure to electric current densities induced by TASER X-26 pulses in adult men

    International Nuclear Information System (INIS)

    There is still an ongoing debate whether or not electronic stun devices (ESDs) induce cardiac fibrillation. To assess the ventricular fibrillation risk of law enforcing electronic control devices, quantitative estimates of cardiac electric current densities induced by delivered electric pulses are essential. Numerical simulations were performed with the finite integration technique and the anatomical model of a standardized European man (NORMAN) segmented into 2 mm voxels and 35 different tissues. The load-dependent delivery of TASER X-26 pulses has been taken into account. Cardiac exposure to electric current densities of vertically and horizontally aligned dart electrodes was quantified and different hit scenarios compared. Since fibrillation thresholds critically depend on exposed volume, the provided quantitative data are essential for risk assessment. The maximum cardiac rms current densities amounted to 7730 A m-2. Such high current densities and exposed cardiac volumes do not exclude ventricular fibrillation.

  9. Numerically simulated cardiac exposure to electric current densities induced by TASER X-26 pulses in adult men

    Energy Technology Data Exchange (ETDEWEB)

    Leitgeb, N; Niedermayr, F; Neubauer, R; Loos, G, E-mail: norbert.leitgeb@tugraz.a [Institute of Clinical Engineering with European Notified Body of Medical Devices, Graz University of Technology, Inffeldgasse 18, A-8010 Graz (Austria)

    2010-10-21

    There is still an ongoing debate whether or not electronic stun devices (ESDs) induce cardiac fibrillation. To assess the ventricular fibrillation risk of law enforcing electronic control devices, quantitative estimates of cardiac electric current densities induced by delivered electric pulses are essential. Numerical simulations were performed with the finite integration technique and the anatomical model of a standardized European man (NORMAN) segmented into 2 mm voxels and 35 different tissues. The load-dependent delivery of TASER X-26 pulses has been taken into account. Cardiac exposure to electric current densities of vertically and horizontally aligned dart electrodes was quantified and different hit scenarios compared. Since fibrillation thresholds critically depend on exposed volume, the provided quantitative data are essential for risk assessment. The maximum cardiac rms current densities amounted to 7730 A m{sup -2}. Such high current densities and exposed cardiac volumes do not exclude ventricular fibrillation.

  10. Including alternative resources in state renewable portfolio standards: Current design and implementation experience

    International Nuclear Information System (INIS)

    As of October 2012, 29 states, the District of Columbia, and Puerto Rico have instituted a renewable portfolio standard (RPS). Each state policy is unique, varying in percentage targets, timetables, and eligible resources. Increasingly, new RPS polices have included alternative resources. Alternative resources have included energy efficiency, thermal resources, and, to a lesser extent, non-renewables. This paper examines state experience with implementing renewable portfolio standards that include energy efficiency, thermal resources, and non-renewable energy and explores compliance experience, costs, and how states evaluate, measure, and verify energy efficiency and convert thermal energy. It aims to gain insights from the experience of states for possible federal clean energy policy as well as to share experience and lessons for state RPS implementation. - Highlights: • Increasingly, new RPS policies have included alternative resources. • Nearly all states provide a separate tier or cap on the quantity of eligible alternative resources. • Where allowed, non-renewables and energy efficiency are being heavily utilized

  11. The impact of Brazilian accounting standards applied to the public sector: current situation and prospects in the Federal Public Administration

    OpenAIRE

    Passos, Luís Henrique Santos

    2015-01-01

    This paper aims to offer a brief assessment of the impact of Brazilian Accounting Standards Applied to Public Sector (NBCASP) in the current scenario and the perspectives that they might bring in the guidance of accounting activities that are performed in the Federal Public Administration. Another aspect to be discussed is closely related to cost management system of the Brazilian Army (SISCUSTOS), resulting from the NBC T 16.5 - Bookkeeping, a fact that puts the Earth Force at the forefront ...

  12. Comparison of two standardized methods of methacholine inhalation challenge in young adults

    DEFF Research Database (Denmark)

    Siersted, H C; Walker, C M; O'Shaughnessy, A D;

    2000-01-01

    In the European Community Respiratory Health Study (ECRHS), airway responsiveness to methacholine was determined using the Mefar dosimeter protocol. Elsewhere, the 2-min tidal breathing method has become the preferred standardized method. The relationship between measurements of responsiveness...... by these two methods is not well established. This study measured airway responsiveness to methacholine by dosimeter and tidal breathing methods in 47 healthy asthmatic subjects aged 20-44 yrs. Tests were performed within 1 week and in random order. Baseline forced expiratory volume in one second (FEV1) varied by...

  13. Lifelong Education for Older Adults in Malta: Current Trends and Future Visions

    Science.gov (United States)

    Formosa, Marvin

    2012-01-01

    With European demographic developments causing a decline of the available workforce in the foreseeable future and the unsustainability of dominant pay-as-you-go pension systems (where contributions from the current workforce sustain pensioners), governments need to come up with strategies to deal with this upcoming challenge and to adjust their…

  14. Prehospital therapeutic hypothermia after cardiac arrest - from current concepts to a future standard

    OpenAIRE

    Hoppu Sanna; Kämäräinen Antti; Silfvast Tom; Virkkunen Ilkka

    2009-01-01

    Abstract Therapeutic hypothermia has been shown to improve survival and neurological outcome after prehospital cardiac arrest. Existing experimental and clinical evidence supports the notion that delayed cooling results in lesser benefit compared to early induction of mild hypothermia soon after return of spontaneous circulation. Therefore a practical approach would be to initiate cooling already in the prehospital setting. The purpose of this review was to evaluate current clinical studies o...

  15. Current National Approach to Healthcare ICT Standardization: Focus on Progress in New Zealand

    OpenAIRE

    Park, Young-Taek; Atalag, Koray

    2015-01-01

    Objectives Many countries try to efficiently deliver high quality healthcare services at lower and manageable costs where healthcare information and communication technologies (ICT) standardisation may play an important role. New Zealand provides a good model of healthcare ICT standardisation. The purpose of this study was to review the current healthcare ICT standardisation and progress in New Zealand. Methods This study reviewed the reports regarding the healthcare ICT standardisation in Ne...

  16. Current Trends in the Monitoring and Treatment of Diabetic Retinopathy in Young Adults

    Directory of Open Access Journals (Sweden)

    Dorota Raczyńska

    2014-01-01

    Full Text Available The diagnosis and treatment of diabetic retinopathy (DR in young adults have significantly improved in recent years. Research methods have widened significantly, for example, by introducing spectral optical tomography of the eye. Invasive diagnostics, for example, fluorescein angiography, are done less frequently. The early introduction of an insulin pump to improve the administration of insulin is likely to delay the development of diabetic retinopathy, which is particularly important for young patients with type 1 diabetes mellitus (T1DM. The first years of diabetes occurring during childhood and youth are the most appropriate to introduce proper therapeutic intervention before any irreversible changes in the eyes appear. The treatment of DR includes increased metabolic control, laserotherapy, pharmacological treatment (antiangiogenic and anti-inflammatory treatment, enzymatic vitreolysis, and intravitreal injections, and surgery. This paper summarizes the up-to-date developments in the diagnostics and treatment of DR. In the literature search, authors used online databases, PubMed, and clinitrials.gov and browsed through individual ophthalmology journals, books, and leading pharmaceutical company websites.

  17. Effects of ionizing radiation on plants and animals at levels implied by current radiation protection standards

    International Nuclear Information System (INIS)

    The 1977 Recommendations of the International Commission on Radiological Protection stated that the commission believes that if man is adequately protected from radiation, other organisms are also likely to be sufficiently protected. The present report examines this statement by considering the effects of ionizing radiation on animals and plants in both terrestrial and aquatic ecosystems. The conclusions are that chronic dose rates of IMGy.d-1 or less are unlikely to cause measurable deleterious effects in terrestrial populations, and that in the aquatic environment limiting chronic dose rates to 10MGy.d-1 to the maximally exposed individuals would provide adequate protection for the population. Thus specific radiation protection standards for non-human organisms are not needed. 193 refs, 2 figs, 7 tabs

  18. Sarcopenia: An Undiagnosed Condition in Older Adults. Current Consensus Definition: Prevalence, Etiology, and Consequences

    OpenAIRE

    2011-01-01

    Sarcopenia, the age associated loss of skeletal muscle mass and function, has considerable societal consequences for the development of frailty, disability and health care planning. A group of geriatricians and scientists from academia and industry met in Rome, Italy on November 18, 2009 to arrive at a consensus definition of sarcopenia. The current consensus definition was approved unanimously by the meeting participants and is as follows: Sarcopenia is defined as the age-associated loss of ...

  19. Prehospital therapeutic hypothermia after cardiac arrest--from current concepts to a future standard.

    Science.gov (United States)

    Kämäräinen, Antti; Hoppu, Sanna; Silfvast, Tom; Virkkunen, Ilkka

    2009-01-01

    Therapeutic hypothermia has been shown to improve survival and neurological outcome after prehospital cardiac arrest. Existing experimental and clinical evidence supports the notion that delayed cooling results in lesser benefit compared to early induction of mild hypothermia soon after return of spontaneous circulation. Therefore a practical approach would be to initiate cooling already in the prehospital setting. The purpose of this review was to evaluate current clinical studies on prehospital induction of mild hypothermia after cardiac arrest. Most reported studies present data on cooling rates, safety and feasibility of different methods, but are inconclusive as regarding to outcome effects. PMID:19821967

  20. Prehospital therapeutic hypothermia after cardiac arrest - from current concepts to a future standard

    Directory of Open Access Journals (Sweden)

    Hoppu Sanna

    2009-10-01

    Full Text Available Abstract Therapeutic hypothermia has been shown to improve survival and neurological outcome after prehospital cardiac arrest. Existing experimental and clinical evidence supports the notion that delayed cooling results in lesser benefit compared to early induction of mild hypothermia soon after return of spontaneous circulation. Therefore a practical approach would be to initiate cooling already in the prehospital setting. The purpose of this review was to evaluate current clinical studies on prehospital induction of mild hypothermia after cardiac arrest. Most reported studies present data on cooling rates, safety and feasibility of different methods, but are inconclusive as regarding to outcome effects.

  1. Prehospital therapeutic hypothermia after cardiac arrest - from current concepts to a future standard

    Science.gov (United States)

    Kämäräinen, Antti; Hoppu, Sanna; Silfvast, Tom; Virkkunen, Ilkka

    2009-01-01

    Therapeutic hypothermia has been shown to improve survival and neurological outcome after prehospital cardiac arrest. Existing experimental and clinical evidence supports the notion that delayed cooling results in lesser benefit compared to early induction of mild hypothermia soon after return of spontaneous circulation. Therefore a practical approach would be to initiate cooling already in the prehospital setting. The purpose of this review was to evaluate current clinical studies on prehospital induction of mild hypothermia after cardiac arrest. Most reported studies present data on cooling rates, safety and feasibility of different methods, but are inconclusive as regarding to outcome effects. PMID:19821967

  2. Imaging in syndrome complex diabetes mellitus. Current standards and future perspectives

    International Nuclear Information System (INIS)

    Diabetes mellitus is a highly prevalent multisystemic disorder with numerous potential complications and substantial socioeconomic consequences. In many cases, the patient history, physical examination and laboratory tests are not sufficient for a comprehensive evaluation of complicating disorders. Imaging modalities, such as sonography, computed tomography (CT) and magnetic resonance imaging (MRI) are of major significance in the evaluation of complicating disorders of diabetes according to current guidelines. Examples include assessment of coronary artery disease, peripheral artery disease, stroke and diabetic foot syndrome. Technical developments allow a substantial reduction in radiation dose and scan time in CT and MRI, respectively and could therefore justify a broader application in this patient population. In the future CT and MRI could also be used for the early detection of diabetic complications. Furthermore, they could also be used for risk stratification, e.g. measurement of hepatic fat content and evaluation of atherosclerosis in whole body MRI. Prior to widespread application of advanced imaging techniques in this patient population, improved outcomes with respect to survival, quality of life and cost-effectiveness need to be demonstrated. Diagnostic imaging modalities for the evaluation of the syndrome complex of diabetic disorders should be used according to the current guidelines but the use is predicted to increase given the high potential in this population. (orig.)

  3. Should perioperative immunonutrition for elective surgery be the current standard of care?

    Science.gov (United States)

    Bharadwaj, Shishira; Trivax, Brandon; Tandon, Parul; Alkam, Bilal; Hanouneh, Ibrahim; Steiger, Ezra

    2016-05-01

    Postoperative infectious complications are independently associated with increased hospital length of stay (LOS) and cost and contribute to significant inpatient morbidity. Many strategies such as avoidance of long periods of preoperative fasting, re-establishment of oral feeding as early as possible after surgery, metabolic control and early mobilization have been used to either prevent or reduce the incidence of postoperative infections. Despite these efforts, it remains a big challenge to our current healthcare system to mitigate the cost of postoperative morbidity. Furthermore, preoperative nutritional status has also been implicated as an independent risk factor for postoperative morbidity. Perioperative nutritional support using enteral and parenteral routes has been shown to decrease postoperative morbidity, especially in high-risk patients. Recently, the role of immunonutrition (IMN) in postoperative infectious complications has been studied extensively. These substrates have been found to positively modulate postsurgical immunosuppression and inflammatory responses. They have also been shown to be cost-effective by decreasing both tpostoperative infectious complications and hospital LOS. In this review, we discuss the postoperative positive outcomes associated with the use of perioperative IMN, their cost-effectiveness, current guidelines and future clinical implications. PMID:27081153

  4. Current Situation and Development Trend of Standards of Lithium Batteries for Electric Vehides

    Institute of Scientific and Technical Information of China (English)

    Meng Xiangfeng; Wen Baozhong

    2012-01-01

    Traction battery is one of the most significant systems in electric vehicles.Its general performance,cycle characteristics and safety performance have crucial influence on the economical efficiency,dynamic property and safety of the vehicle.Therefore traction battery has always been the key area in researches of electric vehicles and its standardization. 1.Main performance indicators of traction batteries As the energy storage device of electric vehicles,the performance of traction battery is very important for the complete vehicle.Requirements of traction battery for electric vehicles should have the following characteristics as high power,high energy,high energy density/specific energy,high power density/specific power,low cost,long life length,abuse resistance,high reliability,good temperature property,short charging time,nice interchangeability etc.Traction batteries used at present are mainly lead-acid cells,nickel-hydride cells and lithium-ion cells.Although none of them can meet all requirements,lithium battery is widely regarded the most promising one with optimal comprehensive performance in recent time.

  5. Limiting the costs of renewable portfolio standards: A review and critique of current methods

    International Nuclear Information System (INIS)

    Over half of U.S. states have renewable portfolio standards (RPSs) mandating that a minimum percentage of electricity sold derives from renewable sources. State RPSs vary widely in how they attempt to control or limit the costs of these RPSs. Approaches utilized include alternative compliance payments, direct rate caps, and cost caps on resource acquisitions, while some states employ no specific limitation at all. This paper describes how states attempt to control RPS costs and discusses the strengths and weaknesses of these various cost controls. There is no one best method; however the experience to date suggests that the most important factors in implementing an effective mechanism to curtail costs are clarity of the rule, consistency in application, and transparency for customers. - Highlights: ▶ We review states' RPS statutes and regulations for mechanisms that attempt to control overall compliance costs. ▶ We categorize the major cost curtailment mechanisms. ▶ For each mechanism, we describe policy designs that are or could be implemented by states. ▶ We identify strengths and weaknesses of the various designs for consideration by policymakers.

  6. [Digital Game Addiction Among Adolescents and Younger Adults: A Current Overview].

    Science.gov (United States)

    Yalçın Irmak, Aylin; Erdoğan, Semra

    2016-01-01

    The games that adolescents and young people used to play in the play grounds and on the streets have been replaced in recent years with cyber games played in front of the computer on the internet or in game arcades. This changing culture has particularly brought up the concept of "digital game addiction", a condition that stems from the steadily growing passion for digital games and their excessived and uncontrolled usage among adolescents and young people. Game addiction in the psychiatry literature has been described as an impulse control disorder characterized by the symptoms such as "the inability to control the time spent on game-playing", "a loss of interest in other activities", "continuing to play despite the adverse effects" and "feeling psychologically deprived when not being able to play"."Although digital game addiction has not been accepted by psychiatric authorities as a psychiatric disorder yet, the increasing psychiatry referrals due to the problems accompanying this disorder, the efforts of families to seek support and solutions, the evidence that similarities with other types of addiction have been revealed by researchers, as well as the current prevalence rates are all factors that suggest the existence of important of the examination of issue. Despite the discussions about the digital game addiction, the literature on the subject is increasing. This article offers an overview of digital game-playing behavior in the light of current literature, seeking to share its findings with health care professionals. PMID:27370064

  7. Fatty acid and vitamin interventions in adults with schizophrenia: a systematic review of the current evidence.

    Science.gov (United States)

    Chia, Siok Ching; Henry, Jeyakumar; Mok, Yee Ming; Honer, William G; Sim, Kang

    2015-12-01

    Current psychopharmacological approaches to reduce psychotic phenomenology in schizophrenia are associated with adverse effects including extrapyramidal and metabolic side effects. In view of the emerging data on nutritional supplementation interventions in schizophrenia which are not entirely consistent, we aimed to review existent studies focusing on fatty acid and vitamin interventions and summarise current evidence on such nutritional supplementations in schizophrenia. We searched the digital databases (ScienceDirect, Scopus, SpringerLINK, PubMed/Medline) for relevant studies pertaining to fatty acid and vitamin supplementation interventions in the management of psychotic symptoms in schizophrenia up to February 2015. Overall, there were more studies conducted on fatty acid over vitamin supplementations in patients with schizophrenia. There were more positive findings in support of fatty acid supplementation compared with vitamin supplementation in the context of specific intervention features (dose of nutrient supplementation, single versus combination nutritional interventions, specific antipsychotic), subject features (older age, long duration of illness, baseline polyunsaturated fatty acid levels) and clinical outcomes (improvements of psychotic symptoms and/or extrapyramidal side effects from antipsychotics). However, investigations of both supplementation modalities were limited by relatively small study sample sizes, short study duration, which precluded further segmentation of impact on more diverse patient subtypes and symptom profiles. Future studies may consider examining larger samples over a longer time period, recruiting younger subjects with shorter duration of illness, examination of different clinical features including specific cognitive domains, and use of single versus combination nutritional interventions. PMID:26354100

  8. Standardized Prevalence Ratios for Atrial Fibrillation in Adult Dialysis Patients in Japan

    Science.gov (United States)

    Ohsawa, Masaki; Tanno, Kozo; Okamura, Tomonori; Yonekura, Yuki; Kato, Karen; Fujishima, Yosuke; Obara, Wataru; Abe, Takaya; Itai, Kazuyoshi; Ogasawara, Kuniaki; Omama, Shinichi; Turin, Tanvir Chowdhury; Miyamatsu, Naomi; Ishibashi, Yasuhiro; Morino, Yoshihiro; Itoh, Tomonori; Onoda, Toshiyuki; Kuribayashi, Toru; Makita, Shinji; Yoshida, Yuki; Nakamura, Motoyuki; Tanaka, Fumitaka; Ohta, Mutsuko; Sakata, Kiyomi; Okayama, Akira

    2016-01-01

    Background While it is assumed that dialysis patients in Japan have a higher prevalence of atrial fibrillation (AF) than the general population, the magnitude of this difference is not known. Methods Standardized prevalence ratios (SPRs) for AF in dialysis patients (n = 1510) were calculated compared to data from the general population (n = 26 454) living in the same area. Results The prevalences of AF were 3.8% and 1.6% in dialysis patients and the general population, respectively. In male subjects, these respective values were 4.9% and 3.3%, and in female subjects they were 1.6% and 0.6%. The SPRs for AF were 2.53 (95% confidence interval [CI], 1.88–3.19) in all dialysis patients, 1.80 (95% CI, 1.30–2.29) in male dialysis patients, and 2.13 (95% CI, 0.66–3.61) in female dialysis patients. Conclusions The prevalence of AF in dialysis patients was twice that in the population-based controls. Since AF strongly contributes to a higher risk of cardiovascular mortality and morbidity in the general population, further longitudinal studies should be conducted regarding the risk of several outcomes attributable to AF among Japanese dialysis patients. PMID:26804038

  9. The adequacy of current occupational standards for protecting the health of nuclear workers

    International Nuclear Information System (INIS)

    It will be clear from the aforegoing that occupational standards have varied over the past 30-40 years since the beginnings of the nuclear industry. The authors perception of risk rates for cancer mortality and genetic effects has changed, such that the rates have been constantly revised upwards. Logically, dose limits should have been reduced in proportion, but this assumes a constant approach to the 'tolerability' or 'acceptability' of risk and this has not been demonstrated. Dose limits are not seen by management in the nuclear industry as the only plank in the structure of radiation protection; emphasis is also being given to the 'optimization' ethic. In these circumstances a good test of the efficacy of the system of radiation control in limiting health effects is needed. As can be seen, no such study is available and, given the doses received and the numbers of workers involved, it is unlikely that any epidemiologic study, apart from studies on miners, will have sufficient statistical power to be totally unequivocal. However, some studies have shown cancer mortality associations with radiation exposure that are significant. Probably the best way to mitigate the inherent drawbacks in these studies is to pool data-sets, and this is being done. Other improvements will include estimates of cancer incidence in countries with cancer registries (e.g., U.K., Canada, and Sweden) and to perhaps go beyond epidemiologic data to consider sensitive biologic markers as indices of exposure. Overall the conclusion must be that the radiation industry cannot be complacent and for some tasks in the processes involved (e.g., uranium mining) there is strong evidence of a history of unacceptable health effects occurring.23 references

  10. Radiotherapy in the management of non-metastatic prostate cancer: Current standards and future opportunities

    International Nuclear Information System (INIS)

    Objectives: The intent of this course is to review issues involved in the management of non-metastatic prostate cancer and to clarify the role of external beam radiotherapy, the use of neo-adjuvant and adjuvant hormonal therapy in conjunction with the radiation, the management of patients with regional metastases and recurrent disease following surgery and radiation. At the end of this course, participants should be able to fluently discuss management issues and strategies across the entire spectrum of non-metastatic prostate cancer. - Pre-treatment prognostic factors including clinical stage, grade, and pre-treatment PSA, will be presented and their relative value in determining therapeutic strategies will be discussed. Strategies to be discussed include standard dose radiation, escalated dose radiation, particle radiation and the use of adjuvant and neo-adjuvant hormonal therapy. - The process of simulation and field design will be presented, the value of CT-based treatment planning, beams-eye view design and the relative value of three-dimensional treatment planning will be discussed. - The significance of prostate and patient movement and strategies for dealing with this will also be presented so that what constitutes an adequate simulation and margin of treatment can be clarified. - The management of newly diagnosed patients, covering the range of low stage/low grade to locally advanced prostate cancer will be discussed. - The relative value of increasing dose, the relative value of using neo-adjuvant and/or adjuvant hormone therapy and the indications for escalated dose will be presented. - Strategies for managing post-prostatectomy patients will be reviewed. Data on adjuvant and therapeutic irradiation for biochemical failure will be presented and a strategy for management will be discussed. - How to deal with patients with residual disease post radiation will be discussed and the relative value of cryotherapy, salvage prostatectomy or hormonal therapy will

  11. A review of current and future treatment strategies for malignant astrocytomas in adults

    International Nuclear Information System (INIS)

    This review discusses available laboratory and clinical data as well as recent advances in our knowledge about prognostic factors and their implications for the design of future clinical trials. Results: Elucidation of the biology of malignant astrocytomas allowed for development of rational new approaches, such as gene therapy and immunotherapy, which could interfere with established treatment regimens or being used independently. Possible strategies include the restoration of defective cancer-inhibitory genes, cell transduction or transfection with antisense DNA corresponding to genes coding for growth factors and their receptors, or with the so-called suicide genes. Several antiangiogenic approaches such as administration of thalidomide, protamine, or monoclonal antibodies against vascular endothelial growth factor have been developed, too. Further treatment possibilities include modulation of drug resistance, e.g. by P-glycoprotein antagonists or O6-alkyl-guanine-DNA-transferase inhibitors, inhibition of matrix metalloproteinases, inhibition of protein kinase C, and administration of agents such as phenylbutyrate or valproic acid that showed promising antiproliferative effects in vitro. Conclusions: Several rational new approaches are now entering clinical trials. In the light of limited survival after standard treatment it is recommended that patients should be offered participation in such trials. (orig.)

  12. Aseptic osteonecrosis of the hip in the adult: current evidence on conservative treatment.

    Science.gov (United States)

    Klumpp, Raymond; Trevisan, Carlo

    2015-01-01

    Treatment of Avascular Osteonecrosis (AVN) of the femoral head to prevent progression to an arthritic hip is a challenging subject. Many conservative treatment options have been proposed in the literature. Weight bearing restriction as a stand-alone therapy is insufficient in preventing disease progression but it may be useful when combined with pharmacological agents or surgery. Bisphosphonate treatment in AVN might be efficient in early stages of disease, however there are no clear recommendations on length of treatment and therapeutic dosage and, considered the limited evidence and potential side effects of treatment, it could be considered in a pre-collapse stage in selected cases. Current literature suggests that low molecular weight heparin could lower disease progression in idiopathic AVN with quality of evidence being very low. Also the evidence to support the use of statins or vasodilators in the treatment of osteonecrosis is very low and their use cannot be recommended. Extracorporeal shock wave therapy may improve pain and function in early stages of disease with a low evidence, but there doesn't seem to be a significant change in time to the occurrence of femoral head collapse. Only one study has been conducted with pulsed electromagnetic fields therefore no recommendation can be given on clinical use of PEF in AVN. Evidence on hyperbaric oxygen therapy in the treatment of AVN is very limited and the high cost of treatment and the limited availability of structures that can provide the service poses other concerns about its feasibility. Based on current evidence, conservative treatment may be considered in early stages of asymptomatic AVN instead of observation only. PMID:27134631

  13. Proposal on ''standardized high current solid targets for cyclotron production of diagnostic and therapeutic radionuclides''

    International Nuclear Information System (INIS)

    The Center for the Development of Radioisotopes and Radiopharmaceuticals - National Nuclear Energy Agency (P2RR-BATAN) has one Cyclotron type CS-30 with maximum 30 MeV proton energy. It is used since 1990 for 201Tl production. The main use of 201Tl in Indonesia is for diagnosis and assessment of myocardial ischaemia, especially diagnosis of coronary artery disease, viability of the heart muscle and forecasting the outcome for patients with coronary disease. The Cyclotron facility is supported with a solid target station, two hot cells and the chemical equipment for electroplating. The yield of 201Tl production currently achieved around 40-50%. The irradiation technique and chemical separation should be improved. We are also very interested in the development of the production of 103Pd via 103Rh (p,n) 103Pd reaction. The objective of this proposal will support the main program of the National Nuclear Energy Agency (BATAN) in enhancement of health care and in providing Cyclotron produced radiopharmaceuticals for hospitals

  14. A Summary of Proposed Changes to the Current ICARTT Format Standards and their Implications to Future Airborne Studies

    Science.gov (United States)

    Northup, E. A.; Kusterer, J.; Quam, B.; Chen, G.; Early, A. B.; Beach, A. L., III

    2015-12-01

    The current ICARTT file format standards were developed for the purpose of fulfilling the data management needs for the International Consortium for Atmospheric Research on Transport and Transformation (ICARTT) campaign in 2004. The goal of the ICARTT file format was to establish a common and simple to use data file format to promote data exchange and collaboration among science teams with similar science objectives. ICARTT has been the NASA standard since 2010, and is widely used by NOAA, NSF, and international partners (DLR, FAAM). Despite its level of acceptance, there are a number of issues with the current ICARTT format, especially concerning the machine readability. To enhance usability, the ICARTT Refresh Earth Science Data Systems Working Group (ESDSWG) was established to enable a platform for atmospheric science data producers, users (e.g. modelers) and data managers to collaborate on developing criteria for this file format. Ultimately, this is a cross agency effort to improve and aggregate the metadata records being produced. After conducting a survey to identify deficiencies in the current format, we determined which are considered most important to the various communities. Numerous recommendations were made to improve upon the file format while maintaining backward compatibility. The recommendations made to date and their advantages and limitations will be discussed.

  15. The current role of sublingual immunotherapy in the treatment of allergic rhinitis in adults and children

    Directory of Open Access Journals (Sweden)

    Simonetta Masieri

    2011-02-01

    Full Text Available Cristoforo Incorvaia1, Simonetta Masieri2, Silvia Scurati3, Silvia Soffia3, Paola Puccinelli3, Franco Frati31Allergy/Pulmonary rehabilitation, Istituti Clinici di Perfezionamento, Milan, Italy; 2ENT Clinic, University La Sapienza, Rome, Italy; 3Medical and Scientific Department, Stallergenes, Milan, ItalyAbstract: Allergic rhinitis is a very common disease affecting about 20% of people. It may be treated by allergen avoidance when possible, by antiallergic drugs such as antihistamines and topical corticosteroids, and by allergen-specific immunotherapy. The latter is the only treatment able to act on the causes and not only on the symptoms of respiratory allergy and is able to maintain its efficacy even after stopping, provided an adequate duration of treatment of 3–5 years is ensured. Sublingual immunotherapy (SLIT was introduced in the 1990s as a possible solution to the problem of adverse systemic reactions to subcutaneous immunotherapy and has been demonstrated by more than 50 trials and globally evaluated thus far by five meta-analyses as an effective and safe treatment for allergic rhinitis. Life-threatening reactions are extremely rare. However, it is important to note that clinical efficacy occurs only if SLIT meets its needs, ie, sufficiently high doses are regularly administered for at least 3 consecutive years. This is often overlooked in the current practice and may prevent the same success reported by trials from being achieved.Keywords: allergic rhinitis, sublingual immunotherapy, efficacy, safety, compliance, meta-analysis 

  16. RT-PCR standardization and bone mineralization after low-level laser therapy on adult osteoblast cells

    Science.gov (United States)

    do Bomfim, Fernando R. C.; Sella, Valéria R. G.; Zanaga, Jéssica Q.; Pereira, Nayara S.; Nouailhetas, Viviane L. A.; Plapler, Hélio

    2014-03-01

    Purpose: Osteoblasts are capable to produce different compounds directly connected to bone mineralization process. This study aims to standardize the reverse transcriptase polymerase chain reaction (RT-PCR) for adult osteoblasts to observe the effect of low level laser therapy on bone mineralization. Methods: Five-millimeter long fragments obtained from the mead femoral region of male Wistar rats were assigned into group A (n=10, laser) and group B (n=10, no laser), submitted to mechanic and enzymatic digestion. After 7 days, cultures of group A were irradiated daily on a single spot with a GaInAs laser, λ=808nm, 200mW/cm2, 2J/cm2, bean diameter of 0,02mm, 5 seconds for 6 days. Group B was manipulated but received no laser irradiation. After 13 days the cells were trypsinized for 15 minute and stabilized with RNA later® for RNA extraction with Trizol®. cDNA synthesis used 10μg of RNA and M-MLV® enzyme. PCR was accomplished using the β-actin gene as a control. Another aliquot was fixed for Hematoxylin-Eosin and Von Kossa staining to visualize bone mineralization areas. Results: Under UV light we observed clearly the amplification of β-actin gene around 400bp. HE and Von Kossa staining showed osteoblast clusters, a higher number of bone cells and well defined mineralization areas in group A. Conclusion: The cell culture, RNA extraction and RT-PCR method for adult osteoblasts was effective, allowing to use these methods for bone mineralization studies. Laser improved bone mineralization and further studies are needed involving osteogenesis, calcium release mechanisms and calcium related channels.

  17. Prevalence of Diagnosed Cancer According to Duration of Diagnosed Diabetes and Current Insulin Use Among U.S. Adults With Diagnosed Diabetes

    OpenAIRE

    Li, Chaoyang; Zhao, Guixiang; Okoro, Catherine A; Wen, Xiao-Jun; Ford, Earl S.; Balluz, Lina S

    2013-01-01

    OBJECTIVE To estimate the prevalence of diagnosed cancer according to duration of diagnosed diabetes and current insulin use among U.S. adults with diagnosed diabetes. RESEARCH DESIGN AND METHODS We analyzed data from 25,964 adults aged ≥18 years with diagnosed diabetes who participated in the 2009 Behavioral Risk Factor Surveillance System. RESULTS After adjustment for potential confounders, we found that the greater the duration of diagnosed diabetes, the higher the prevalence of diagnosed ...

  18. Demographic Characteristics and IQ among Adults: Analysis of the WAIS-R Standardization Sample as a Function of the Stratification Variables.

    Science.gov (United States)

    Reynolds, Cecil R.; And Others

    1987-01-01

    Analyzed data from standardization sample of 1981 Wechsler Adult Intelligence Scale-Revised (WAIS-R) to determine relationships of WAIS-R intelligence quotients (IQs) to demographic variables upon which sample was stratified. Found significant differences in mean IQs due to race and education level; sizeable differences for occupational groups;…

  19. Upgrade of the ESA DRAMA OSCAR Tool: Analysis of Disposal Strategies Considering Current Standards for Future Solar and Geomagnetic Activity

    Science.gov (United States)

    Braun, V.; Sanchez-Ortiz, N.; Gelhaus, J.; Kebschull, C.; Flegel, S.; Mockel, M.; Wiedemann, C.; Krag, H.; Vorsmann, P.

    2013-08-01

    In 2008 the UN General Assembly adopted resolution 62/217, endorsing the space debris mitigation guidelines (SDMG) of the UN Committee on the Peaceful Uses of Outer Space (UNCOPUOS). These guidelines contain recommendations for satellite operators to implement measures for various mission phases in order to reduce the further accumulation of space debris in space and especially within the protected regions. These are defined within the SDMG as being the LEO region (up to 2,000 km altitude) and the GEO region (∼200 km in altitude around the GEO altitude and ∼15 degrees latitude). In the first version of ESA's DRAMA tool suite, OSCAR (Orbital SpaceCraft Active Removal) was designed as a tool to allow users the analysis of different disposal stragies for spacecraft in the LEO and GEO region. The upgrade of the ESA DRAMA tool suite by TUBS and DEIMOS under ESA/ESOC contract included the development of a renewed version of the existing OSCAR tool, allowing in its current version the consideration of different future solar and geomagnetic activity scenarios and besides the already known disposal systems (chemical and electric propulsion, as well as electrodynamic tether) the analysis of the orbital evolution using drag augmentation devices. One of the primary goals was to implement techniques recommended by current standards. The recommendations from the SDMG were used for the definition of the critical regions as well as compliance criteria, the user may check his disposal strategy against. For satellites operating in GEO, the ISO 26872:2010 (Space Systems - Disposal of satellites operating at geosynchronous altitude) standard was accounted for. For the generation of future solar and geomagnetic activity, the standards ISO 27852:2011 (Space Systems -Estimation of orbit lifetime) and the ECSS-E-ST-10-04C (Space engineering - Space environment) have been considered and recommended modeling approaches were implemented. In this paper, the OSCAR tool is presented, giving

  20. Screening for Diabetic Retinopathy in Adults with Learning Disability: Current Uptake and Adjustments to Facilitate Equality of Access

    Science.gov (United States)

    Pilling, Rachel F.

    2015-01-01

    Equality of access to health care for adults with learning disability has been in the spotlight in the UK in recent years due to publication of several reports. Adults with learning disability are thought to account for a significant proportion of the diabetic population in the UK. A list of adults known to the learning disability health…

  1. Standardization of Chemical Analytical Techniques for Pyrolysis Bio-Oil: History, Challenges, and Current Status of Methods

    Energy Technology Data Exchange (ETDEWEB)

    Ferrell, Jack R., III; Olarte, Mariefel V.; Christensen, Earl D.; Padmaperuma, Asanga B.; Connatser, Raynella M.; Stankovikj, Filip; Meier, Dietrich; Paasikallio, Ville

    2016-09-01

    In this perspective, we discuss the standardization of analytical techniques for pyrolysis bio-oils, including the current status of methods, and our opinions on future directions. First, the history of past standardization efforts is summarized, and both successful and unsuccessful validation of analytical techniques highlighted. The majority of analytical standardization studies to-date has tested only physical characterization techniques. Here, we present results from an international round robin on the validation of chemical characterization techniques for bio-oils. Techniques tested included acid number, carbonyl titrations using two different methods (one at room temperature and one at 80 degrees C), 31P NMR for determination of hydroxyl groups, and a quantitative gas chromatography-mass spectrometry (GC-MS) method. Both carbonyl titration and acid number methods have yielded acceptable inter-laboratory variabilities. 31P NMR produced acceptable results for aliphatic and phenolic hydroxyl groups, but not for carboxylic hydroxyl groups. As shown in previous round robins, GC-MS results were more variable. Reliable chemical characterization of bio-oils will enable upgrading research and allow for detailed comparisons of bio-oils produced at different facilities. Reliable analytics are also needed to enable an emerging bioenergy industry, as processing facilities often have different analytical needs and capabilities than research facilities. We feel that correlations in reliable characterizations of bio-oils will help strike a balance between research and industry, and will ultimately help to determine metrics for bio-oil quality. Finally, the standardization of additional analytical methods is needed, particularly for upgraded bio-oils.

  2. Associations between a History of Traumatic Brain Injuries and Current Cigarette Smoking, Substance Use, and Elevated Psychological Distress in a Population Sample of Canadian Adults.

    Science.gov (United States)

    Ilie, Gabriela; Adlaf, Edward M; Mann, Robert E; Ialomiteanu, Anca; Hamilton, Hayley; Rehm, Jürgen; Asbridge, Mark; Cusimano, Michael D

    2015-07-15

    This study describes the prevalence of reported history of traumatic brain injury (TBI) and its association with reports of current substance use, cigarette smoking, and psychological distress among Canadian adults in a population sample. A cross-sectional sample of 1999 Ontario adults 18-93 years of age were surveyed by telephone in 2011 as part of the Center for Addiction and Mental Health's ongoing representative survey of adult mental health and substance use in Ontario, Canada. Loss of consciousness for at least 5 min or at least one overnight hospitalization resulting from symptoms associated with the TBI injury represented minimum criteria for TBI. An estimated 16.8% (95% confidence interval, 14.8, 19.0) of adults reported a TBI in their lifetime. Men had higher prevalence of TBI than women. Adults who reported a history of TBI had higher odds of reported past-year daily smoking (adjusted odds ratio [AOR] = 2.15), using cannabis (AOR = 2.80) and nonmedical opioids (AOR = 2.90), as well as screened significantly for recent elevated psychological distress (AOR = 1.97) in the past few weeks, compared to adults without a history of TBI. Co-occurrence of a history of TBI with current elevated psychological distress and substance use warrants vigilance among medical practitioners to assess the possibility of a history of TBI during reviews of the history leading to the occurrence of these conditions. PMID:25496189

  3. Gender Dysphoria in Adults.

    Science.gov (United States)

    Zucker, Kenneth J; Lawrence, Anne A; Kreukels, Baudewijntje P C

    2016-03-28

    Gender dysphoria (GD), a term that denotes persistent discomfort with one's biologic sex or assigned gender, replaced the diagnosis of gender identity disorder in the Diagnostic and Statistical Manual of Mental Disorders in 2013. Subtypes of GD in adults, defined by sexual orientation and age of onset, have been described; these display different developmental trajectories and prognoses. Prevalence studies conclude that fewer than 1 in 10,000 adult natal males and 1 in 30,000 adult natal females experience GD, but such estimates vary widely. GD in adults is associated with an elevated prevalence of comorbid psychopathology, especially mood disorders, anxiety disorders, and suicidality. Causal mechanisms in GD are incompletely understood, but genetic, neurodevelopmental, and psychosocial factors probably all contribute. Treatment of GD in adults, although largely standardized, is likely to evolve in response to the increasing diversity of persons seeking treatment, demands for greater client autonomy, and improved understanding of the benefits and limitations of current treatment modalities. PMID:26788901

  4. Dietary intake and nutritional status of micronutrients in adults with cystic fibrosis in relation to current recommendations.

    Science.gov (United States)

    Li, Li; Somerset, Shawn

    2016-08-01

    An increased prevalence of cystic fibrosis (CF) related complications such as impaired bone health and diabetes has accompanied increased survival of patients with CF. This review was conducted to determine the extent to which adults with CF are meeting current nutrition recommendations for micronutrients in association with CF-related complications management. Although dietary intake and nutritional status in CF has improved significantly in recent decades, micronutrient status seems to have diverged. While vitamin A and E intakes appear adequate, frequent vitamin D and K deficiency/insufficiency and compromised bone health in CF, occurs despite supplementation. Although deficiency of water-soluble vitamins and minerals is uncommon, ongoing surveillance will enhance overall health outcomes, particularly in cases of CF-related liver disease and deteriorated lung function and bone health. Salt and fluid status in CF may also need attention due to diminished thirst sensation and voluntary rehydration. Further investigation in micronutrient status optimisation in CF will inform the development of more effective and targeted nutrition therapies to enable integration of more refined recommendations for micronutrient intakes in CF based on individual needs and disease progression. PMID:26159903

  5. Current understanding of treatment and management protocol for adult diabetic in-patients at a tertiary care hospital

    International Nuclear Information System (INIS)

    Objective: To assess the current understanding of treatment and management protocols for adult diabetic in-patients at a tertiary care hospital. Methods: This cross-sectional study, conducted at the Civil Hospital Karachi from July to September 2009, involved 450 participants, who were interviewed through a well-structured questionnaire regarding the patient's demography, clinical features, past medical history, type of diabetes mellitus, duration, associated complications, and also involved patient notes for laboratory tests and management. SPSSv15.0 was used for descriptive analysis. Results: The study population of 450 diabetics had 144 (32%) males and 306 (68%) females. Of the total, 435 (96.7%) patients had type 2 diabetes. There were 231 (51%) patients using insulin, 168 (37.3%) oral hypoglycaemic drugs, and 51 (11.3%) using both. Among patients using insulin, regular insulin usage stood at 30% followed by a combination of regular insulin and NPH (26.7%) and NPH alone at 6%. The most popular drug used was metformin (27.3%) and the least used drug was glitazones (4%). In the study population, 73.3% patients controlled their diabetes with diet, and 24.7% with regular exercise. Conclusion: Majority of the study population had type 2 diabetes with a female preponderance. Insulin was prescribed for half the patients. Metformin was the most frequently used oral hypoglycaemic drug. (author)

  6. Achieving transparency in carbon labelling for construction materials – Lessons from current assessment standards and carbon labels

    International Nuclear Information System (INIS)

    Highlights: • The evolution of international GHG standards is reviewed. • The evolution of international carbon labelling schemes is reviewed. • The transparency requirements in carbon labelling schemes are revealed. • Key recommendations are provided to improve transparency in carbon labelling. - Abstract: The construction industry is one of the largest sources of carbon emissions. Manufacturing of raw materials, such as cement, steel and aluminium, is energy intensive and has considerable impact on carbon emissions level. Due to the rising recognition of global climate change, the industry is under pressure to reduce carbon emissions. Carbon labelling schemes are therefore developed as meaningful yardsticks to measure and compare carbon emissions. Carbon labelling schemes can help switch consumer-purchasing habits to low-carbon alternatives. However, such switch is dependent on a transparent scheme. The principle of transparency is highlighted in all international greenhouse gas (GHG) standards, including the newly published ISO 14067: Carbon footprint of products – requirements and guidelines for quantification and communication. However, there are few studies which systematically investigate the transparency requirements in carbon labelling schemes. A comparison of five established carbon labelling schemes, namely the Singapore Green Labelling Scheme, the CarbonFree (the U.S.), the CO2 Measured Label and the Reducing CO2 Label (UK), the CarbonCounted (Canada), and the Hong Kong Carbon Labelling Scheme is therefore conducted to identify and investigate the transparency requirements. The results suggest that the design of current carbon labels have transparency issues relating but not limited to the use of a single sign to represent the comprehensiveness of the carbon footprint. These transparency issues are partially caused by the flexibility given to select system boundary in the life cycle assessment (LCA) methodology to measure GHG emissions. The

  7. Financing Adult Education: How Adequate Are Current Sources in Facilitating Access and Participation in Centres in Murang'a South Sub-County, Murang'a County, Kenya?

    Science.gov (United States)

    Maina, Ndonga James; Orodho, John Aluko

    2016-01-01

    The thrust of this study was to examine the level of adequacy of current sources in facilitating access and participation in adult education centres in Murang'a South Sub-County, Murang'a County, Kenya. The study adopted the descriptive survey design. Combinations of purposive and stratified random sampling techniques were used to select 82…

  8. Standards-Based Classroom Assessments of English Proficiency: A Review of Issues, Current Developments, and Future Directions for Research

    Science.gov (United States)

    Llosa, Lorena

    2011-01-01

    With the United States' adoption of a standards-based approach to education, most attention has focused on the large-scale, high-stakes assessments intended to measure students' mastery of standards for accountability purposes. Less attention has been paid to the role of standards-based assessments in the classroom. The purpose of this paper is to…

  9. Routine Immunization of Adults in Canada: Review of the Epidemiology of Vaccine-Preventable Diseases and Current Recommendations for Primary Prevention

    Directory of Open Access Journals (Sweden)

    Michael D Parkins

    2009-01-01

    Full Text Available Vaccination is one of the greatest achievements in public health of the 20th century. However, the success of vaccine uptake and adherence to immunization guidelines seen in pediatric populations has not been observed among adult Canadians. As a result of the disparity in susceptibility to vaccine-preventable disease, there has been an increasing shift of vaccine-preventable childhood diseases into adult populations. Accordingly, morbidity and mortality due to vaccine-preventable illnesses now occur disproportionately in adults. All Canadians, irrespective of age, should have immunity to measles, mumps, rubella, tetanus, diphtheria, pertussis and varicella. All adult Canadians with significant medical comorbidities or those older than 65 years of age should receive the pneumococcal polysaccharide vaccine and yearly trivalent inactivate influenza vaccines. The present review summarizes the burden of illness of these vaccine-preventable diseases in the Canadian adult population and reviews the current immunization recommendations. Vaccination of all Canadians to these common agents remains a vital tool to decrease individual morbidity and mortality and reduce the overall burden of preventable disease in Canada.

  10. Influence of Adult Knee Height, Age at First Birth, Migration, and Current Age on Adult Physical Function of Bangladeshi Mothers and Daughters in the United Kingdom and Bangladesh

    Directory of Open Access Journals (Sweden)

    Barry Bogin

    2014-01-01

    Full Text Available In the United Kingdom, Bangladeshi women have the lowest self-reported levels of physical activity and some of the highest levels of metabolic disease of all ethnic groups. To better understand these risks for poor health we employed life course and intergenerational hypotheses to predict lower body physical function in a sample of 121 Bangladeshi mothers (40–70 years old and one of their adult daughters (17–36 years old living in Bangladesh or in the UK. For the mothers, older age and shorter knee height predicted reduced lower body physical function. Knee height is a biomarker of nutrition and health status between birth and puberty. Age at first birth did not have a significant effect. For daughters, older age and migration to the UK predicted reduced lower body physical function. We controlled for total stature and fatness in all analyses. UK-born daughters were taller than BD-born daughters living in the UK, mostly due to differences in knee height. These new findings support previous research indicating that early life health and adequate nutritional status, along with appropriate adult physical activity and diet, may decrease risks for poor physical function, morbidity, and premature mortality.

  11. Compulsive internet use in adults: a study of prevalence and drivers within the current economic climate in the UK

    OpenAIRE

    Quinones-Garcia, Cristina; Korak-Kakabadse, Nada

    2014-01-01

    Compulsive Internet Use (CIU) refers to a maladaptive relationship with the tool, including a loss of control over the use, the use for mood change and withdrawal symptoms. Most studies have relied on student samples, thus little is known about its prevalence in adults. The first objective of this study was to examine CIU in adults that were either employed (N = 260) or unemployed within the last year (N = 256). Second, the drivers of CIU were examined, with a focus on attitudes that reflecte...

  12. Validation of Five Minimally Obstructive Methods to Estimate Physical Activity Energy Expenditure in Young Adults in Semi-Standardized Settings

    OpenAIRE

    Mikkel B. Schneller; Pedersen, Mogens T.; Nidhi Gupta; Mette Aadahl; Andreas Holtermann

    2015-01-01

    We compared the accuracy of five objective methods, including two newly developed methods combining accelerometry and activity type recognition (Acti4), against indirect calorimetry, to estimate total energy expenditure (EE) of different activities in semi-standardized settings. Fourteen participants performed a standardized and semi-standardized protocol including seven daily life activity types, while having their EE measured by indirect calorimetry. Simultaneously, physical activity was qu...

  13. Adult-to-adult right lobe living donor liver transplantation: Comparison of endoscopic retrograde cholangiography with standard T2-weighted magnetic resonance cholangiography for evaluation of donor biliary anatomy

    Institute of Scientific and Technical Information of China (English)

    Perdita Wietzke-Braun; Felix Braun; Dieter Müller; Thomas Lorf; Burckhardt Ringe; Giuliano Ramadori

    2006-01-01

    AIM: To compare the value of endoscopic retrograde cholangiography (ERC) and standard T2-weighted magnetic resonance cholangiography (MRC) in the evaluation process as adult-to-adult right lobe living donor liver transplantation (LDLTx) demands a successful outcome, and exact knowledge of the biliary tree is implicated to avoid biliary complications,postoperatively.METHODS: After starting the LDLTx program, 18 liver transplant candidates were selected for LDLTx by a stepwise evaluation process. ERC and standard T2-weighted MRC were performed to evaluate the biliary system of the donor liver. The anatomical findings of ERC and MRC mapping were compared usingthe Ohkubo classification.RESULTS: ERC allowed mapping of the whole biliary system in 15/15 (100%) cases, including 14/15 (93.3%)with biliary variants while routine MRC was only accurate in 2/13 (15.4%) cases. MRC was limited in depicting the biliary system proximal of the hepatic bifurcation.Postoperative biliary complications occurred in 2 donors and 8 recipients. Biliary complications were associated with Ohkubo type C, E or G in 6/8 recipients, and 2/3recipients with biliary leak received a graft with multiple (≥2) bile ducts.CONCLUSION: Pretransplant ERC is safe and superior over standard MRC for detection of biliary variations that occur with a high frequency. However, precise knowledge of biliary variants did not reduce the incidence of postoperative biliary complications.

  14. The application of strength and power related field tests in older adults : criteria, current status and a future perspective

    NARCIS (Netherlands)

    Regterschot, G. Ruben H.; Morat, Tobias; Folkersma, Marjanne; Zijlstra, Wiebren

    2015-01-01

    Leg muscle strength (LMS) and leg muscle power (LMP) are determinants of aspects of functional status and important parameters for measuring intervention effects in older adults. Field tests are often used for the evaluation of LMS and LMP in older persons. However, criteria important for the applic

  15. Radiotherapy of high-grade gliomas: current standards and new concepts, innovations in imaging and radiotherapy, and new therapeutic approaches.

    Science.gov (United States)

    Dhermain, Frederic

    2014-01-01

    The current standards in radiotherapy of high-grade gliomas (HGG) are based on anatomic imaging techniques, usually computed tomography (CT) scanning and magnetic resonance imaging (MRI). The guidelines vary depending on whether the HGG is a histological grade 3 anaplastic glioma (AG) or a grade 4 glioblastoma multiforme (GBM). For AG, T2-weighted MRI sequences plus the region of contrast enhancement in T1 are considered for the delineation of the gross tumor volume (GTV), and an isotropic expansion of 15 to 20 mm is recommended for the clinical target volume (CTV). For GBM, the Radiation Therapy Oncology Group favors a two-step technique, with an initial phase (CTV1) including any T2 hyperintensity area (edema) plus a 20 mm margin treated with up to 46 Gy in 23 fractions, followed by a reduction in CTV2 to the contrast enhancement region in T1 with an additional 25 mm margin. The European Organisation of Research and Treatment of Cancer recommends a single-phase technique with a unique GTV, which comprises the T1 contrast enhancement region plus a margin of 20 to 30 mm. A total dose of 60 Gy in 30 fractions is usually delivered for GBM, and a dose of 59.4 Gy in 33 fractions is typically given for AG. As more than 85% of HGGs recur in field, dose-escalation studies have shown that 70 to 75 Gy can be delivered in 6 weeks with relevant toxicities developing in 60 Gy. Trials delivering a SIB into a biological GTV showed the feasibility of this treatment, but the final results, in terms of clinical benefits for HGG patients, are still pending. Many issues have been identified: the variety of MRI and PET machines (and amino-acid tracers), the heterogeneity of the protocols used for image acquisition and post-treatment, the geometric distortion and the unreliable algorithms for co-registration of brain anatomy with functional maps, and the semi-quiescent but highly invasive HGG cells. These issues could be solved by the homogenization of the protocols and software

  16. Radiotherapy of high-grade gliomas: current standards and new concepts, innovations in imaging and radiotherapy, and new therapeutic approaches

    Directory of Open Access Journals (Sweden)

    Frederic Dhermain

    2014-01-01

    Full Text Available The current standards in radiotherapy of high-grade gliomas (HGG are based on anatomic imaging techniques, usually computed tomography (CT scanning and magnetic resonance imaging (MRI. The guidelines vary depending on whether the HGG is a histological grade 3 anaplastic glioma (AG or a grade 4 glioblastoma multiforme (GBM. For AG, T2-weighted MRI sequences plus the region of contrast enhancement in T1 are considered for the delineation of the gross tumor volume (GTV, and an isotropic expansion of 15 to 20 mm is recommended for the clinical target volume (CTV. For GBM, the Radiation Therapy Oncology Group favors a two-step technique, with an initial phase (CTV1 including any T2 hyperintensity area (edema plus a 20 mm margin treated with up to 46 Gy in 23 fractions, followed by a reduction in CTV2 to the contrast enhancement region in T1 with an additional 25 mm margin. The European Organisation of Research and Treatment of Cancer recommends a single-phase technique with a unique GTV, which comprises the T1 contrast enhancement region plus a margin of 20 to 30 mm. A total dose of 60 Gy in 30 fractions is usually delivered for GBM, and a dose of 59.4 Gy in 33 fractions is typically given for AG. As more than 85% of HGGs recur in field, dose-escalation studies have shown that 70 to 75 Gy can be delivered in 6 weeks with relevant toxicities developing in 60 Gy. Trials delivering a SIB into a biological GTV showed the feasibility of this treatment, but the final results, in terms of clinical benefits for HGG patients, are still pending. Many issues have been identified: the variety of MRI and PET machines (and amino-acid tracers, the heterogeneity of the protocols used for image acquisition and post-treatment, the geometric distortion and the unreliable algorithms for co-registration of brain anatomy with functional maps, and the semi-quiescent but highly invasive HGG cells. These issues could be solved by the homogenization of the protocols and

  17. Comparison of immunogenicity and safety of four doses and four double doses vs. standard doses of hepatitis B vaccination in HIV-infected adults: a randomized, controlled trial.

    Directory of Open Access Journals (Sweden)

    Kanokporn Chaiklang

    Full Text Available BACKGROUND: HBV vaccination is recommended in HIV-infected adults with CD4+ cell count >200/mm(3 although the efficacy is only 33.3% -65%. We conducted a randomized, controlled trial to evaluate the efficacy and safety of three regimens of HBV vaccination at Chiang Mai University Hospital, Thailand. METHODS: From February 4, 2011 to May 4, 2012, 132 HIV-infected adults with CD4+ cell counts >200 cells/mm(3, undetectable plasma HIV-1 RNA, and negative for all HBV markers were randomly assigned to receive one of three recombinant vaccine (Hepavax-Gene(® Berna, Korea regimens: 20 μg IM at months 0, 1, and 6 (Standard doses group, n=44, 20 μg IM at months 0, 1, 2, 6 (four doses group, n=44, or 40 μg IM at months 0, 1, 2, and 6 (four double doses group, n=44. The primary outcomes were to compare the immunogenicity and safety between the four-doses groups with the Standard doses group. RESULTS: At months 7 and 12, the percentages of responders (anti-HBs ≥ 10 mIU/mL were 88.6% and 70.4% in the Standard doses group, 93.2% and 86.4% in the four doses group, (P=0.713 and 0.119, and 95.4% and 88.6% in the four double doses group, (P=0.434 and 0.062, respectively. Factors associated with a high titer level (anti-HBs ≥ 100 mIU/mL were vaccination schedule and younger age. The most common adverse event was pain at the injection site (42.4%; this was significantly more frequent in the four double doses group compared to the Standard doses group. No serious adverse events were observed. CONCLUSIONS: In Northern Thailand, the standard three-doses HBV vaccination in HIV-infected adults with CD4+ cell counts >200 cells/mm(3 and undetectable plasma HIV-1 RNA is highly effective. Although regimens of four injections of either standard or double doses could not significantly increase the response rate, these regimens may induce higher levels of antibody to the virus. TRIAL REGISTRATION INFORMATION: ClinicalTrials.gov; NCT1289106; http://clinicaltrials.gov/ct2

  18. Current Class Management in Adult Colleges%新形势下成人高校班主任班级管理工作探讨

    Institute of Scientific and Technical Information of China (English)

    马福生

    2011-01-01

    The current status of students in adult colleges is low attendance, poor learning outcomes. Therefore, the management of adult classes in colleges and universities also needs to be improved for a feasible management approach to guarantee a successful teaching.%目前有部分成人高校的学员现状是出勤率较低,学习效果较差,因此对成人高校的班级管理工作还需要不断探索,寻求科学的管理办法,使成人高校的班级管理工作顺利进行,以保证教育教学质量,使学员的学业能顺利完成。

  19. Projection of bootstrap current in the ITER with standard type I ELMy H-mode and steady state scenarios

    Directory of Open Access Journals (Sweden)

    Thawatchai Onjun

    2012-02-01

    Full Text Available The investigation of bootstrap current formation in ITER is carried out using BALDUR integrated predictive modelingcode. The combination of Mixed B/gB anomalous transport model and NLCASS module together with the pedestal model isused in BALDUR code to simulate the time evolution of temperature, density, and plasma current profiles. It was found inthe simulations that without the presence of ITB, a minimal fraction of bootstrap current (as well as low fusion performancewas achieved. The enhancement due to ITB depends sensitively on the strength of toroidal velocity. A sensitivity study wasalso carried out to optimize the bootstrap current fraction and plasma performance. It was found that the bootstrap currentfraction slightly improved; while the plasma performance greatly improved with increasing of NBI power or pedestal temperature.On the other hand, higher impurity concentration resulted in a significant degradation of fusion performance, buta smaller degradation in bootstrap current.

  20. Knee pain and osteoarthritis in older adults: a review of community burden and current use of primary health care

    OpenAIRE

    Peat, G; McCarney, R.; Croft, P

    2001-01-01

    BACKGROUND—Osteoarthritis is the single most common cause of disability in older adults, and most patients with the condition will be managed in the community and primary care.
AIM—To discuss case definition of knee osteoarthritis for primary care and to summarise the burden of the condition in the community and related use of primary health care in the United Kingdom.
DESIGN—Narrative review.
METHOD—A literature search identified studies of incidence and prevalence of knee pain, disability, ...

  1. Distance Education Policy Standards: A Review of Current Regional and National Accrediting Organizations in the United States

    Science.gov (United States)

    Keil, Suzanne; Brown, Abbie

    2014-01-01

    A review of distance education accreditation policies and standards written by the six United States regional accrediting commissions and two national accrediting organizations: the Middle States Commission on Higher Education; the New England Association of Schools and Colleges - Commission on Institutions of Higher Education; the North Central…

  2. Current Understanding of the Pathways Involved in Adult Stem and Progenitor Cell Migration for Tissue Homeostasis and Repair.

    Science.gov (United States)

    Goichberg, Polina

    2016-08-01

    With the advancements in the field of adult stem and progenitor cells grows the recognition that the motility of primitive cells is a pivotal aspect of their functionality. There is accumulating evidence that the recruitment of tissue-resident and circulating cells is critical for organ homeostasis and effective injury responses, whereas the pathobiology of degenerative diseases, neoplasm and aging, might be rooted in the altered ability of immature cells to migrate. Furthermore, understanding the biological machinery determining the translocation patterns of tissue progenitors is of great relevance for the emerging methodologies for cell-based therapies and regenerative medicine. The present article provides an overview of studies addressing the physiological significance and diverse modes of stem and progenitor cell trafficking in adult mammalian organs, discusses the major microenvironmental cues regulating cell migration, and describes the implementation of live imaging approaches for the exploration of stem cell movement in tissues and the factors dictating the motility of endogenous and transplanted cells with regenerative potential. PMID:27209167

  3. Validation of Five Minimally Obstructive Methods to Estimate Physical Activity Energy Expenditure in Young Adults in Semi-Standardized Settings

    Directory of Open Access Journals (Sweden)

    Mikkel B. Schneller

    2015-03-01

    Full Text Available We compared the accuracy of five objective methods, including two newly developed methods combining accelerometry and activity type recognition (Acti4, against indirect calorimetry, to estimate total energy expenditure (EE of different activities in semi-standardized settings. Fourteen participants performed a standardized and semi-standardized protocol including seven daily life activity types, while having their EE measured by indirect calorimetry. Simultaneously, physical activity was quantified by an ActivPAL3, two ActiGraph GT3X+’s and an Actiheart. EE was estimated by the standard ActivPAL3 software (ActivPAL, ActiGraph GT3X+ (ActiGraph and Actiheart (Actiheart, and by a combination of activity type recognition via Acti4 software and activity counts per minute (CPM of either a hip- or thigh-worn ActiGraph GT3X+ (AGhip + Acti4 and AGthigh + Acti4. At group level, estimated physical activities EE by Actiheart (MSE = 2.05 and AGthigh + Acti4 (MSE = 0.25 were not significantly different from measured EE by indirect calorimetry, while significantly underestimated by ActiGraph, ActivPAL and AGhip + Acti4. AGthigh + Acti4 and Actiheart explained 77% and 45%, of the individual variations in measured physical activity EE by indirect calorimetry, respectively. This study concludes that combining accelerometer data from a thigh-worn ActiGraph GT3X+ with activity type recognition improved the accuracy of activity specific EE estimation against indirect calorimetry in semi-standardized settings compared to previously validated methods using CPM only.

  4. Ecological momentary assessment versus standard assessment instruments for measuring mindfulness, depressed mood, and anxiety among older adults.

    Science.gov (United States)

    Moore, Raeanne C; Depp, Colin A; Wetherell, Julie Loebach; Lenze, Eric J

    2016-04-01

    As mobile data capture tools for patient-reported outcomes proliferate in clinical research, a key dimension of measure performance is sensitivity to change. This study compared performance of patient-reported measures of mindfulness, depression, and anxiety symptoms using traditional paper-and-pencil forms versus real-time, ambulatory measurement of symptoms via ecological momentary assessment (EMA). Sixty-seven emotionally distressed older adults completed paper-and-pencil measures of mindfulness, depression, and anxiety along with two weeks of identical items reported during ambulatory monitoring via EMA before and after participation in a randomized trial of Mindfulness-Based Stress Reduction (MBSR) or a health education intervention. We calculated effect sizes for these measures across both measurement approaches and estimated the Number-Needed-to-Treat (NNT) in both measurement conditions. Study outcomes greatly differed depending on which measurement method was used. When EMA was used to measure clinical symptoms, older adults who participated in the MBSR intervention had significantly higher mindfulness and significantly lower depression and anxiety than participants in the health education intervention at post-treatment. However, these significant changes in symptoms were not found when outcomes were measured with paper-and-pencil measures. The NNT for mindfulness and depression measures administered through EMA were approximately 25-50% lower than NNTs derived from paper-and-pencil administration. Sensitivity to change in anxiety was similar across administration modes. In conclusion, EMA measures of depression and mindfulness substantially outperformed paper-and-pencil measures with the same items. The additional resources associated with EMA in clinical trials would seem to be offset by its greater sensitivity to detect change in key outcome variables. PMID:26851494

  5. Validation of five minimally obstructive methods to estimate physical activity energy expenditure in young adults in semi-standardized settings

    DEFF Research Database (Denmark)

    Schneller, Mikkel Bo; Pedersen, Mogens Theisen; Gupta, Nidhi; Aadahl, Mette; Holtermann, Andreas

    2015-01-01

    We compared the accuracy of five objective methods, including two newly developed methods combining accelerometry and activity type recognition (Acti4), against indirect calorimetry, to estimate total energy expenditure (EE) of different activities in semi-standardized settings. Fourteen particip......We compared the accuracy of five objective methods, including two newly developed methods combining accelerometry and activity type recognition (Acti4), against indirect calorimetry, to estimate total energy expenditure (EE) of different activities in semi-standardized settings. Fourteen...... ActivPAL3 software (ActivPAL), ActiGraph GT3X+ (ActiGraph) and Actiheart (Actiheart), and by a combination of activity type recognition via Acti4 software and activity counts per minute (CPM) of either a hip- or thigh-worn ActiGraph GT3X+ (AGhip + Acti4 and AGthigh + Acti4). At group level, estimated...

  6. Current Methods for Extraction and Concentration of Enteric Viruses from Fresh Fruit and Vegetables: Towards International Standards

    DEFF Research Database (Denmark)

    Croci, L.; Dubois, E.; Cook, N.;

    2008-01-01

    Virus-contaminated soft fruits or vegetables are increasingly identified as causes of foodborne viral illness. Noroviruses and hepatitis A virus are the most common pathogens in viral infections transmitted by these kinds of foods. To improve microbiological detection and monitoring and to increase...... insights into the contribution of fruits and vegetables to foodborne viral transmission, sensitive, reliable, and standardized methods are needed. More studies on virus detection methods for foods are being published, but validated consensus protocols are not yet available. In this paper, different...

  7. Neural correlates of a standardized version of the trail making test in young and elderly adults: a functional near-infrared spectroscopy study.

    Science.gov (United States)

    Müller, Laura D; Guhn, Anne; Zeller, Julia B M; Biehl, Stefanie C; Dresler, Thomas; Hahn, Tim; Fallgatter, Andreas J; Polak, Thomas; Deckert, Jürgen; Herrmann, Martin J

    2014-04-01

    The trail making test (TMT) is a widely applied diagnostic tool measuring executive functioning in order to discriminate between healthy and pathological aging processes. However, due to its paper-and-pencil nature it is difficult to adapt for functional brain imaging. Related neural underpinnings even in healthy aging are mostly unknown since no consistent administration for imaging is available. In this study a standardized implementation of the TMT for functional near-infrared spectroscopy (fNIRS) is proposed to investigate associated frontal cortex activation in healthy young (mean age 25.7 ± 3.02 years) and elderly adults (mean age 70.95 ± 3.55 years). The TMT consisted of a number condition (TMT-A), an alternating number and letter condition (TMT-B) as well as a control task. Behavioral results demonstrated that elderly participants performed slower but committed a similar number of errors compared to younger adults. The fNIRS results showed that particularly the TMT-B provoked bilateral activation in the ventro- and dorsolateral prefrontal cortex (vlPFC and dlPFC) as well as in premotor regions. Elderly participants displayed more significantly activated channels and a different activation pattern compared to younger participants especially manifesting in more bilateral dlPFC activation. In line with the hemispheric asymmetry reduction in elderly adults (HAROLD) model, the results were interpreted as an additional need for cognitive control resources in elderly participants. This study succeeded in implementing an appropriate version of the TMT for fNIRS and helps elucidating neural aging effects associated with this task. PMID:24524911

  8. ['Gold standard', not 'golden standard'

    NARCIS (Netherlands)

    Claassen, J.A.H.R.

    2005-01-01

    In medical literature, both 'gold standard' and 'golden standard' are employed to describe a reference test used for comparison with a novel method. The term 'gold standard' in its current sense in medical research was coined by Rudd in 1979, in reference to the monetary gold standard. In the same w

  9. Instrumentation Amplifier using Differential voltage second generation current conveyor (DVCCII) in standard 0.18 μm CMOS technology

    OpenAIRE

    Ashish Panchal; Pramod Kumar Jain; D.S. Ajnar

    2011-01-01

    In this paper a new CMOS high performance, high frequency current mode signal DVCC-II is presented. Output stage AB amplifier provides high driving capability ±0.9mA. It provides rail to rail inputoutputoperation. The proposed DVCC-II has been designed in 0.18μm CMOS technology with 1.8V supply voltage. SPECTRA RF simulator is used for circuit simulation. In low voltage sub-micrometer analog circuitaccuracy and precision can be limited by the finite gain as well as by input offset voltage. Pr...

  10. National Institute of Standards and Technology measurement service of the optical properties of biomedical phantoms: current status

    Science.gov (United States)

    Lemaillet, Paul; Cooksey, Catherine C.; Levine, Zachary H.; Pintar, Adam L.; Hwang, Jeeseong; Allen, David W.

    2016-03-01

    The National Institute of Standards and Technology (NIST) has maintained scales for reflectance and transmittance over several decades. The scales are primarily intended for regular transmittance, mirrors, and solid surface scattering diffusers. The rapidly growing area of optical medical imaging needs a scale for volume scattering of diffuse materials that are used to mimic the optical properties of tissue. Such materials are used as phantoms to evaluate and validate instruments under development intended for clinical use. To address this need, a double-integrating sphere based instrument has been installed to measure the optical properties of tissue-mimicking phantoms. The basic system and methods have been described in previous papers. An important attribute in establishing a viable calibration service is the estimation of measurement uncertainties. The use of custom models and comparisons with other established scales enabled uncertainty measurements. Here, we describe the continuation of those efforts to advance the understanding of the uncertainties through two independent measurements: the bidirectional reflectance distribution function and the bidirectional transmittance distribution function of a commercially available solid biomedical phantom. A Monte Carlo-based model is used and the resulting optical properties are compared to the values provided by the phantom manufacturer.

  11. Instrumentation Amplifier using Differential voltage second generation current conveyor (DVCCII in standard 0.18 μm CMOS technology

    Directory of Open Access Journals (Sweden)

    Ashish Panchal

    2011-08-01

    Full Text Available In this paper a new CMOS high performance, high frequency current mode signal DVCC-II is presented. Output stage AB amplifier provides high driving capability ±0.9mA. It provides rail to rail inputoutputoperation. The proposed DVCC-II has been designed in 0.18μm CMOS technology with 1.8V supply voltage. SPECTRA RF simulator is used for circuit simulation. In low voltage sub-micrometer analog circuitaccuracy and precision can be limited by the finite gain as well as by input offset voltage. Proposed circuit features have high CMRR, high gain and bandwidth that can be achieved simultaneously without requiring well matched register.

  12. Quantifying Ecological Literacy in an Adult Western Community: The Development and Application of a New Assessment Tool and Community Standard

    Science.gov (United States)

    Pitman, Sheryn D.; Daniels, Christopher B.

    2016-01-01

    Knowledge and understanding about how the Earth functions and supports life create the foundation for ecological literacy. Industrialisation, urbanisation and population growth have resulted in changed relationships between many human communities and the natural world. A potential consequence is a compromised capability to make well-informed decisions about how to live sustainably. To gain a measure of ecological literacy within the South Australian community, we collaborated with senior scientists and educators to develop and apply an instrument with the capacity to determine indicative levels of ecological knowledge and understanding. A formal, variable credit, multiple-choice assessment instrument was distributed online to groups and individuals within diverse community sectors and industries. Quantitative analyses of scores indicated that levels of ecological knowledge and understanding within a self-selected sample of over one thousand individuals ranged from very low to extremely high, with the majority of respondents achieving moderate to high scores. This instrument has a demonstrated capacity to determine indicative levels of ecological literacy within and between individuals and groups. It is able to capture mastery of ecological knowledge and understanding achieved through both formal and informal pathways. Using the results, we have been able to establish a range of standards and an aspirational target score for the South Australian community. The value of this work is in its potential to deliver insights into relationships between humans and the rest of the natural world, and into characteristics of eco-literate individuals and communities, that might not otherwise emerge. PMID:26938258

  13. Quantifying Ecological Literacy in an Adult Western Community: The Development and Application of a New Assessment Tool and Community Standard.

    Science.gov (United States)

    Pitman, Sheryn D; Daniels, Christopher B

    2016-01-01

    Knowledge and understanding about how the Earth functions and supports life create the foundation for ecological literacy. Industrialisation, urbanisation and population growth have resulted in changed relationships between many human communities and the natural world. A potential consequence is a compromised capability to make well-informed decisions about how to live sustainably. To gain a measure of ecological literacy within the South Australian community, we collaborated with senior scientists and educators to develop and apply an instrument with the capacity to determine indicative levels of ecological knowledge and understanding. A formal, variable credit, multiple-choice assessment instrument was distributed online to groups and individuals within diverse community sectors and industries. Quantitative analyses of scores indicated that levels of ecological knowledge and understanding within a self-selected sample of over one thousand individuals ranged from very low to extremely high, with the majority of respondents achieving moderate to high scores. This instrument has a demonstrated capacity to determine indicative levels of ecological literacy within and between individuals and groups. It is able to capture mastery of ecological knowledge and understanding achieved through both formal and informal pathways. Using the results, we have been able to establish a range of standards and an aspirational target score for the South Australian community. The value of this work is in its potential to deliver insights into relationships between humans and the rest of the natural world, and into characteristics of eco-literate individuals and communities, that might not otherwise emerge. PMID:26938258

  14. Imaging in syndrome complex diabetes mellitus. Current standards and future perspectives; Bildgebung im Syndromkomplex Diabetes mellitus. Stellenwert und Chancen

    Energy Technology Data Exchange (ETDEWEB)

    Hetterich, H.; Schafnitzel, A. [Klinikum der Ludwig-Maximilians-Universitaet, Campus Grosshadern, Institut fuer Klinische Radiologie, Muenchen (Germany); Bamberg, F. [Eberhard-Karls-Universitaet, Abteilung fuer Diagnostische und Interventionelle Radiologie, Tuebingen (Germany)

    2015-04-01

    Diabetes mellitus is a highly prevalent multisystemic disorder with numerous potential complications and substantial socioeconomic consequences. In many cases, the patient history, physical examination and laboratory tests are not sufficient for a comprehensive evaluation of complicating disorders. Imaging modalities, such as sonography, computed tomography (CT) and magnetic resonance imaging (MRI) are of major significance in the evaluation of complicating disorders of diabetes according to current guidelines. Examples include assessment of coronary artery disease, peripheral artery disease, stroke and diabetic foot syndrome. Technical developments allow a substantial reduction in radiation dose and scan time in CT and MRI, respectively and could therefore justify a broader application in this patient population. In the future CT and MRI could also be used for the early detection of diabetic complications. Furthermore, they could also be used for risk stratification, e.g. measurement of hepatic fat content and evaluation of atherosclerosis in whole body MRI. Prior to widespread application of advanced imaging techniques in this patient population, improved outcomes with respect to survival, quality of life and cost-effectiveness need to be demonstrated. Diagnostic imaging modalities for the evaluation of the syndrome complex of diabetic disorders should be used according to the current guidelines but the use is predicted to increase given the high potential in this population. (orig.) [German] Diabetes mellitus ist eine hochpraevalente Multisystemerkrankung mit zahlreichen Komplikationen und bedeutenden soziooekonomischen Konsequenzen. Die Folgeerkrankungen koennen oft nicht abschliessend mittels Anamnese, koerperlicher Untersuchung und laborchemischen Verfahren evaluiert werden. Radiologische Verfahren wie die Sonographie, Computertomographie (CT) und Magnetresonanztomographie (MRT) haben gemaess verschiedener Leitlinien einen festen Stellenwert bei der

  15. Current Understanding on the Role of Standard and Immunoproteasomes in Inflammatory/Immunological Pathways of Multiple Sclerosis

    Directory of Open Access Journals (Sweden)

    Elena Bellavista

    2014-01-01

    Full Text Available The ubiquitin-proteasome system is the major intracellular molecular machinery for protein degradation and maintenance of protein homeostasis in most human cells. As ubiquitin-proteasome system plays a critical role in the regulation of the immune system, it might also influence the development and progression of multiple sclerosis (MS. Both ex vivo analyses and animal models suggest that activity and composition of ubiquitin-proteasome system are altered in MS. Proteasome isoforms endowed of immunosubunits may affect the functionality of different cell types such as CD8+ and CD4+ T cells and B cells as well as neurons during MS development. Furthermore, the study of proteasome-related biomarkers, such as proteasome antibodies and circulating proteasomes, may represent a field of interest in MS. Proteasome inhibitors are already used as treatment for cancer and the recent development of inhibitors selective for immunoproteasome subunits may soon represent novel therapeutic approaches to the different forms of MS. In this review we describe the current knowledge on the potential role of proteasomes in MS and discuss the pro et contra of possible therapies for MS targeting proteasome isoforms.

  16. Employment and Adults Who Are Deaf or Hard of Hearing: Current Status and Experiences of Barriers, Accommodations, and Stress in the Workplace.

    Science.gov (United States)

    Punch, Renée

    2016-01-01

    In an integrative review of the literature covering the period 2004-2016, the author presents a current picture of the situation of people who are deaf or hard of hearing (DHH) relative to employment and careers-particularly the barriers, facilitators, and stress levels experienced by working DHH adults. First, an overview is provided of findings from recent reports on employment outcomes for people who are DHH. Second, the author reviews the literature on employment and workplace barriers, facilitators, and accommodations for people who are DHH, and relates findings about DHH people's workplace-related stress and fatigue levels and the associated issues of job demand, job control, and social support in the workplace. The article concludes with a discussion of the implications of these findings, in particular the ways in which barriers to full participation of DHH people in the labor market can be addressed. PMID:27477043

  17. State-specific prevalence of current cigarette smoking and smokeless tobacco use among adults aged ≥18 years - United States, 2011-2013.

    Science.gov (United States)

    Nguyen, Kimberly; Marshall, LaTisha; Hu, Sean; Neff, Linda

    2015-05-22

    Cigarette smoking and the use of smokeless tobacco both cause substantial morbidity and premature mortality. The concurrent use of these products might increase dependence and the risk for tobacco-related disease and death. State-specific estimates of prevalence and relative percent change in current cigarette smoking, smokeless tobacco use, and concurrent cigarette smoking and smokeless tobacco use among U.S. adults during 2011-2013, developed using data from the Behavioral Risk Factor Surveillance System (BRFSS), indicate statistically significant (padvertising and promotion, controlling access to tobacco products, and promoting cessation assistance for smokers to quit, as well as continuing and implementing mass media campaigns that contain graphic anti-smoking ads, such as the Tips from Former Smokers (TIPS) campaign. PMID:25996096

  18. The mediating sex-specific effect of psychological distress on the relationship between adverse childhood experiences and current smoking among adults

    Directory of Open Access Journals (Sweden)

    Strine Tara W

    2012-07-01

    Full Text Available Abstract Background Research suggests that ACEs have a long-term impact on the behavioral, emotional, and cognitive development of children. These disruptions can lead to adoption of unhealthy coping behaviors throughout the lifespan. The present study sought to examine psychological distress as a potential mediator of sex-specific associations between adverse childhood experiences (ACEs and adult smoking. Method Data from 7,210 Kaiser-Permanente members in San Diego California collected between April and October 1997 were used. Results Among women, psychological distress mediated a significant portion of the association between ACEs and smoking (21% for emotional abuse, 16% for physical abuse, 15% for physical neglect, 10% for parental separation or divorce. Among men, the associations between ACEs and smoking were not significant. Conclusions These findings suggest that for women, current smoking cessation strategies may benefit from understanding the potential role of childhood trauma.

  19. High Seroprotection Rate Induced by Intradermal Administration of a Recombinant Hepatitis B Vaccine in Young Healthy Adults: Comparison with Standard Intramuscular Vaccination

    International Nuclear Information System (INIS)

    Intradermal (ID) vaccination has been proposed as a cost-saving alternative for administration of Hepatitis B (HB) vaccine to implement of mass vaccination of high-risk groups, particularly in developing countries. Therefore, the effectiveness of ID vaccination needs to be evaluated and verified in different ethnic backgrounds. The present study is a randomized trail using a recombinant vaccine (Heberbiovac) to compare immunogenecity and safety of an intradermal low-dose (4 μg) with standard dose (20 μg) of intramuscular (IM) vaccination in healthy Iranian population. Participants were 143 healthy Iranian medical and nursing students randomly allocated to ID or IM vaccination group. The vaccine was inoculated at 0, 1 and 6 months intervals. Serum samples were collected 1 month after the last vaccination and the anti-HBs response was determined using ELISA. The overall seroprotection rate (anti-HBs level ≥ 10IU/L) was 97.3% for ID vaccination group, which was not different from that of IM vaccination group (98.55%)(p= 0.99). Similarly, geometric mean titers (GMT) of anti-HBs were not significantly different between ID (1164.1IU/L) and IM (1071.8IU/L) vaccination groups (p= 0.4). There was no significant difference in seroprotection rate and GMT of anti-HBs between sexes. Although induration and hyperpigmentation at the site of injection were more frequently observed in ID vaccination group, no other clinically adverse effects were observed in both vaccination groups. We conclude that the ID route, which would require one-fifth of the standard dose, would be suitable for use in certain groups such as high-risk adults when the cost of vaccine is the inhibiting factor for mass vaccination

  20. Achieving the salt intake target of 6 g/day in the current food supply in free-living adults using two dietary education strategies.

    Science.gov (United States)

    Ireland, Dani-Maree; Clifton, Peter M; Keogh, Jennifer B

    2010-05-01

    There are national targets for salt intake of 6 g salt/day in Australia and the United States. Despite this, there is limited knowledge about the effectiveness of dietary education in reducing salt intake to this level. The objective of this study was to investigate whether dietary education enabled a reduction in salt consumption. In an 8-week parallel study, 49 healthy free-living adults were recruited from the Adelaide community by newspaper advertisement. In a randomized parallel design, participants received dietary education to choose foods identified by either Australia's National Heart Foundation Tick symbol or by the Food Standards Australia and New Zealand's low-salt guideline of 120 mg sodium/100 g food. Sodium excretion was assessed by 24-hour urinary sodium collections at baseline and weeks 4 and 8. Participants' experiences of following the education strategies were recorded by self-administered questionnaire. These data were collected between August and October 2008. Forty-three participants completed the study. After 8 weeks, urinary sodium excretion decreased from 121+/-50 to 106+/-47 mmol/24 hours (7.3+/-3.0 to 6.4+/-2.8 g salt/24 hours) in the Tick group and from 132+/-44 to 98+/-50 mmol/24 hours (7.9+/-2.6 to 6.0+/-3.0 g salt/24 hours) in the Food Standards Australia New Zealand group (Pfood choice, difficulty when eating out, and increased time associated with identifying foods. In conclusion, dietary sodium reduction is possible among free-living individuals who received dietary advice. PMID:20430138

  1. Prevalence of psychological trauma and association with current health and functioning in a sample of HIV-infected and HIV-uninfected Tanzanian adults.

    Directory of Open Access Journals (Sweden)

    Brian W Pence

    Full Text Available In high income nations, traumatic life experiences such as childhood sexual abuse are much more common in people living with HIV/AIDS (PLWHA than the general population, and trauma is associated with worse current health and functioning. Virtually no data exist on the prevalence or consequences of trauma for PLWHA in low income nations.We recruited four cohorts of Tanzanian patients in established medical care for HIV infection (n = 228, individuals newly testing positive for HIV (n = 267, individuals testing negative for HIV at the same sites (n = 182, and a random sample of community-dwelling adults (n = 249. We assessed lifetime prevalence of traumatic experiences, recent stressful life events, and current mental health and health-related physical functioning. Those with established HIV infection reported a greater number of childhood and lifetime traumatic experiences (2.1 and 3.0 respectively than the community cohort (1.8 and 2.3. Those with established HIV infection reported greater post-traumatic stress disorder (PTSD symptomatology and worse current health-related physical functioning. Each additional lifetime traumatic experience was associated with increased PTSD symptomatology and worse functioning.This study is the first to our knowledge in an HIV population from a low income nation to report the prevalence of a range of potentially traumatic life experiences compared to a matched community sample and to show that trauma history is associated with poorer health-related physical functioning. Our findings underscore the importance of considering psychosocial characteristics when planning to meet the health needs of PLWHA in low income countries.

  2. The U.S. Forest Service's analysis of cumulative effects to wildlife: A study of legal standards, current practice, and ongoing challenges on a National Forest

    International Nuclear Information System (INIS)

    Cumulative effects analysis (CEA) allows natural resource managers to understand the status of resources in historical context, learn from past management actions, and adapt future activities accordingly. U.S. federal agencies are required to complete CEA as part of environmental impact assessment under the National Environmental Policy Act (NEPA). Past research on CEA as part of NEPA has identified significant deficiencies in CEA practice, suggested methodologies for handling difficult aspects of CEA, and analyzed the rise in litigation over CEA in U.S. courts. This article provides a review of the literature and legal standards related to CEA as it is done under NEPA and then examines current practice on a U.S. National Forest, utilizing qualitative methods in order to provide a detailed understanding of current approaches to CEA. Research objectives were to understand current practice, investigate ongoing challenges, and identify impediments to improvement. Methods included a systematic review of a set of NEPA documents and semi-structured interviews with practitioners, scientists, and members of the public. Findings indicate that the primary challenges associated with CEA include: issues of both geographic and temporal scale of analysis, confusion over the purpose of the requirement, the lack of monitoring data, and problems coordinating and disseminating data. Improved monitoring strategies and programmatic analyses could support improved CEA practice.

  3. 华东电网短路电流计算标准研究%Short-Circuit Current Calculation Standard for East China Power Grid

    Institute of Scientific and Technical Information of China (English)

    冯煜尧; 祝瑞金; 庄侃沁; 李建华

    2012-01-01

    Nowadays five IEC 60909-based calculation methods are commonly used for domestic short-circuit current calculation.On the basis of small system calculation examples,and artificial short circuit field test data for East China Power Grid,this paper theoretically analyzes the validity of the five short-circuit current calculation methods and the calculation influencing factors.Finally,short-circuit current calculation standard is proposed applicable for power grid of no less than 220 kV in East China.%介绍了目前国内短路电流计算工程应用主要根据IEC 60909形成的5种常用的计算方法,从理论分析的角度,结合小系统算例、华东实际电网以及现场人工短路试验实测数据,分析了5种短路计算方法的合理性以及影响短路电流计算的因素,并提出了适合华东220 kV及以上电网短路电流计算的标准。

  4. On the evolution of the standard genetic code: vestiges of critical scale invariance from the RNA world in current prokaryote genomes.

    Directory of Open Access Journals (Sweden)

    Marco V José

    Full Text Available Herein two genetic codes from which the primeval RNA code could have originated the standard genetic code (SGC are derived. One of them, called extended RNA code type I, consists of all codons of the type RNY (purine-any base-pyrimidine plus codons obtained by considering the RNA code but in the second (NYR type and third (YRN type reading frames. The extended RNA code type II, comprises all codons of the type RNY plus codons that arise from transversions of the RNA code in the first (YNY type and third (RNR nucleotide bases. In order to test if putative nucleotide sequences in the RNA World and in both extended RNA codes, share the same scaling and statistical properties to those encountered in current prokaryotes, we used the genomes of four Eubacteria and three Archaeas. For each prokaryote, we obtained their respective genomes obeying the RNA code or the extended RNA codes types I and II. In each case, we estimated the scaling properties of triplet sequences via a renormalization group approach, and we calculated the frequency distributions of distances for each codon. Remarkably, the scaling properties of the distance series of some codons from the RNA code and most codons from both extended RNA codes turned out to be identical or very close to the scaling properties of codons of the SGC. To test for the robustness of these results, we show, via computer simulation experiments, that random mutations of current genomes, at the rates of 10(-10 per site per year during three billions of years, were not enough for destroying the observed patterns. Therefore, we conclude that most current prokaryotes may still contain relics of the primeval RNA World and that both extended RNA codes may well represent two plausible evolutionary paths between the RNA code and the current SGC.

  5. Energy retrofit of an office building by substitution of the generation system: performance evaluation via dynamic simulation versus current technical standards

    International Nuclear Information System (INIS)

    Constructions built in Italy before 1945 (about 30% of the total built stock) feature low energy efficiency. Retrofit actions in this field can lead to valuable energetic and economic savings. In this work, we ran a dynamic simulation of a historical building of the University of Pisa during the heating season. We firstly evaluated the energy requirements of the building and the performance of the existing natural gas boiler, validated with past billings of natural gas. We also verified the energetic savings obtainable by the substitution of the boiler with an air-to-water electrically-driven modulating heat pump, simulated through a cycle-based model, evaluating the main economic metrics. The cycle-based model of the heat pump, validated with manufacturers' data available only at specified temperature and load conditions, can provide more accurate results than the simplified models adopted by current technical standards, thus increasing the effectiveness of energy audits

  6. Primary Radiation Damage in Materials. Review of Current Understanding and Proposed New Standard Displacement Damage Model to Incorporate in Cascade Defect Production Efficiency and Mixing Effects

    International Nuclear Information System (INIS)

    Under the auspices of the NEA Nuclear Science Committee (NSC), the Working Party on Multi-scale Modelling of Fuels and Structural Materials for Nuclear Systems (WPMM) was established in 2008 to assess the scientific and engineering aspects of fuels and structural materials, aiming at evaluating multi-scale models and simulations as validated predictive tools for the design of nuclear systems, fuel fabrication and performance. The WPMM's objective is to promote the exchange of information on models and simulations of nuclear materials, theoretical and computational methods, experimental validation, and related topics. It also provides member countries with up-to-date information, shared data, models and expertise. The WPMM Expert Group on Primary Radiation Damage (PRD) was established in 2009 to determine the limitations of the NRT-dpa standard, in the light of both atomistic simulations and known experimental discrepancies, to revisit the NRT-dpa standard and to examine the possibility of proposing a new improved standard of primary damage characteristics. This report reviews the current understanding of primary radiation damage from neutrons, ions and electrons (excluding photons, atomic clusters and more exotic particles), with emphasis on the range of validity of the 'displacement per atom' (dpa) concept in all major classes of materials with the exception of organics. The report also introduces an 'athermal recombination-corrected dpa' (arc-dpa) relation that uses a relatively simple functional to address the well-known issue that 'displacement per atom' (dpa) overestimates damage production in metals under energetic displacement cascade conditions, as well as a 'replacements-per-atom' (rpa) equation, also using a relatively simple functional, that accounts for the fact that dpa is understood to severely underestimate actual atom relocation (ion beam mixing) in metals. (authors)

  7. The International Labour Standard and Our National Current Situation%国际劳动标准与我国执行现状

    Institute of Scientific and Technical Information of China (English)

    陈盼盼

    2014-01-01

    The article will discuss about the current situation in five core standards for workers from the perspective of origin and development of the international workers ’ convention , including abolishment of slave labor, freedom of gathering , organizing the trade union , collective bargaining right , abolishment of exploiting young workers , and eliminating of occupation discrimination .The article will also talk about the challenges we are facing up to in the process of implementing the international standard for workers as a developing and labor intensive country and discuss on some countermeasures and advice .%本文从国际劳工公约的由来与发展出发,分别从立法层面与执行层面分析我国在五项核心劳工标准中的现状,其中包括废除强迫劳动、结社自由、组织工会和集体谈判权、消除剥削童工、消除就业歧视。通过对现状的分析,指出作为发展中国家、劳动密集型、以贴牌制造生产为主的中国在执行国际劳工标准上所面临的挑战,以及应对挑战的对策建议。

  8. Effect of hawthorn standardized extract on flow mediated dilation in prehypertensive and mildly hypertensive adults: a randomized, controlled cross-over trial

    Directory of Open Access Journals (Sweden)

    Asher Gary N

    2012-03-01

    Full Text Available Abstract Background Hawthorn extract has been used for cardiovascular diseases for centuries. Recent trials have demonstrated its efficacy for the treatment of heart failure, and the results of several small trials suggest it may lower blood pressure. However, there is little published evidence to guide its dosing. The blood pressure lowering effect of hawthorn has been linked to nitric oxide-mediated vasodilation. The aim of this study was to investigate the relationship between hawthorn extract dose and brachial artery flow mediated dilation (FMD, an indirect measure of nitric oxide release. Methods We used a four-period cross-over design to evaluate brachial artery FMD in response to placebo or hawthorn extract (standardized to 50 mg oligomeric procyanidin per 250 mg extract. Randomly sequenced doses of hawthorn extract (1000 mg, 1500 mg, and 2500 mg and placebo were assigned to each participant. Doses were taken twice daily for 3 1/2 days followed by FMD and a 4-day washout before proceeding to the next dosing period. Results Twenty-one prehypertensive or mildly hypertensive adults completed the study. There was no evidence of a dose-response effect for our main outcome (FMD percent or any of our secondary outcomes (absolute change in brachial artery diameter and blood pressure. Most participants indicated that if given evidence that hawthorn could lower their blood pressure, they would be likely to use it either in conjunction with or instead of lifestyle modification or anti-hypertensive medications. Conclusion We found no evidence of a dose-response effect of hawthorn extract on FMD. If hawthorn has a blood pressure lowering effect, it is likely to be mediated via an NO-independent mechanism. Trial Registration This trial has been registered with ClinicalTrials.gov, a service of the U.S. National Institutes of Health: NCT01331486.

  9. Comparison of standardized uptake values measured on 18F-NaF PET/CT scans using three different tube current intensities

    Directory of Open Access Journals (Sweden)

    Agnes Araujo Valadares

    2015-02-01

    Full Text Available Objective: To analyze standardized uptake values (SUVs using three different tube current intensities for attenuation correction on 18FNaF PET/CT scans. Materials and Methods: A total of 254 18F-NaF PET/CT studies were analyzed using 10, 20 and 30 mAs. The SUVs were calculated in volumes of interest (VOIs drawn on three skeletal regions, namely, right proximal humeral diaphysis (RH, right proximal femoral diaphysis (RF, and first lumbar vertebra (LV1 in a total of 712 VOIs. The analyses covered 675 regions classified as normal (236 RH, 232 RF, and 207 LV1. Results: Mean SUV for each skeletal region was 3.8, 5.4 and 14.4 for RH, RF, and LV1, respectively. As the studies were grouped according to mAs value, the mean SUV values were 3.8, 3.9 and 3.7 for 10, 20 and 30 mAs, respectively, in the RH region; 5.4, 5.5 and 5.4 for 10, 20 and 30 mAs, respectively, in the RF region; 13.8, 14.9 and 14.5 for 10, 20 and 30 mAs, respectively, in the LV1 region. Conclusion: The three tube current values yielded similar results for SUV calculation.

  10. Comparison of standardized uptake values measured on 18F-NaF PET/CT scans using three different tube current intensities

    International Nuclear Information System (INIS)

    Objective: to analyze standardized uptake values (SUVs) using three different tube current intensities for attenuation correction on 18FNaF PET/CT scans. Materials and methods: a total of 254 18F-NaF PET/CT studies were analyzed using 10, 20 and 30 mAs. The SUVs were calculated in volumes of interest (VOIs) drawn on three skeletal regions, namely, right proximal humeral diaphysis (RH), right proximal femoral diaphysis (RF), and first lumbar vertebra (LV1) in a total of 712 VOIs. The analyses covered 675 regions classified as normal (236 RH, 232 RF, and 207 LV1). Results: mean SUV for each skeletal region was 3.8, 5.4 and 14.4 for RH, RF, and LV1, respectively. As the studies were grouped according to mAs value, the mean SUV values were 3.8, 3.9 and 3.7 for 10, 20 and 30 mAs, respectively, in the RH region; 5.4, 5.5 and 5.4 for 10, 20 and 30 mAs, respectively, in the RF region; 13.8, 14.9 and 14.5 for 10, 20 and 30 mAs, respectively, in the LV1 region. Conclusion: the three tube current values yielded similar results for SUV calculation. (author)

  11. Comparison of standardized uptake values measured on {sup 18}F-NaF PET/CT scans using three different tube current intensities

    Energy Technology Data Exchange (ETDEWEB)

    Valadares, Agnes Araujo; Woellner, Eduardo Bechtloff; Sapienza, Marcelo Tatit; Buchpiguel, Carlos Alberto, E-mail: agnesvaladares@me.com [Universidade de Sao Paulo (HC/FMUSP), Sao Paulo, SP (Brazil). Fac. de Medicina. Hospital das Clinicas; Duarte, Paulo Schiavom; Coura-Filho, George Barberio [Instituto do Cancer do Estado de Sao Paulo Octavio Frias de Oliveira (ICESP), Sao Paulo, SP (Brazil)

    2015-01-15

    Objective: to analyze standardized uptake values (SUVs) using three different tube current intensities for attenuation correction on {sup 18}FNaF PET/CT scans. Materials and methods: a total of 254 {sup 18}F-NaF PET/CT studies were analyzed using 10, 20 and 30 mAs. The SUVs were calculated in volumes of interest (VOIs) drawn on three skeletal regions, namely, right proximal humeral diaphysis (RH), right proximal femoral diaphysis (RF), and first lumbar vertebra (LV1) in a total of 712 VOIs. The analyses covered 675 regions classified as normal (236 RH, 232 RF, and 207 LV1). Results: mean SUV for each skeletal region was 3.8, 5.4 and 14.4 for RH, RF, and LV1, respectively. As the studies were grouped according to mAs value, the mean SUV values were 3.8, 3.9 and 3.7 for 10, 20 and 30 mAs, respectively, in the RH region; 5.4, 5.5 and 5.4 for 10, 20 and 30 mAs, respectively, in the RF region; 13.8, 14.9 and 14.5 for 10, 20 and 30 mAs, respectively, in the LV1 region. Conclusion: the three tube current values yielded similar results for SUV calculation. (author)

  12. Are currently GFR estimating equations and standard Kt/V value adequate for advanced chronic kidney disease (CKD) frail elderly patients?

    Science.gov (United States)

    Musso, Carlos G; Alvarez-Gregori, Joaquin; Jauregui, Jose; Núñez, Juan F Macías

    2015-07-01

    Chronic kidney disease (CKD) elderly patients have a reduced glomerular filtration rate (GFR) due to the combination of ageing and chronic nephropathy damage. This situation is very important to be taken into account in order to prescribe an adequate medication and dialysis dose in this aged group. Besides, cognitive and urinary incontinence problems make difficult to obtain an adequate 24-h urine collection in order to evaluate creatinine clearance in this group. Thus, a reliable GFR estimating equation would be very useful for assisting elderly CKD patients. Additionally, Kt/V is the main parameter currently used for dosing dialysis in stage V CKD young and elderly patients. However, frailty and sarcopenia are prevalent disorders usually suffered by old people, who also present many physiological changes that could make GFR estimating equations and standard Kt/V value to become unreliable in this particular group. In conclusion, based on all these facts, it seems crucial for clinical geriatric nephrology to carefully evaluate how reliable current GFR estimating equations are, as well as which would be an adequate Kt/V value in CKD frail elderly patients. PMID:25993909

  13. Pediatric Provider's Perspectives on the Transition to Adult Health Care for Youth with Autism Spectrum Disorder: Current Strategies and Promising New Directions

    Science.gov (United States)

    Kuhlthau, Karen A.; Warfield, Marji E.; Hurson, Jill; Delahaye, Jennifer; Crossman, Morgan K.

    2015-01-01

    Few youth with autism spectrum disorder (ASD) nationally report receiving services to help them transition from the pediatric health care system to the adult health care system. For example, only one-fifth (21.1%) of youth with ASD receive any transition planning services. To better understand why the transition from pediatric to adult health care…

  14. Osmotic Edema Rapidly Increases Neuronal Excitability Through Activation of NMDA Receptor-Dependent Slow Inward Currents in Juvenile and Adult Hippocampus.

    Science.gov (United States)

    Lauderdale, Kelli; Murphy, Thomas; Tung, Tina; Davila, David; Binder, Devin K; Fiacco, Todd A

    2015-01-01

    Cellular edema (cell swelling) is a principal component of numerous brain disorders including ischemia, cortical spreading depression, hyponatremia, and epilepsy. Cellular edema increases seizure-like activity in vitro and in vivo, largely through nonsynaptic mechanisms attributable to reduction of the extracellular space. However, the types of excitability changes occurring in individual neurons during the acute phase of cell volume increase remain unclear. Using whole-cell patch clamp techniques, we report that one of the first effects of osmotic edema on excitability of CA1 pyramidal cells is the generation of slow inward currents (SICs), which initiate after approximately 1 min. Frequency of SICs increased as osmolarity decreased in a dose-dependent manner. Imaging of real-time volume changes in astrocytes revealed that neuronal SICs occurred while astrocytes were still in the process of swelling. SICs evoked by cell swelling were mainly nonsynaptic in origin and NMDA receptor-dependent. To better understand the relationship between SICs and changes in neuronal excitability, recordings were performed in increasingly physiological conditions. In the absence of any added pharmacological reagents or imposed voltage clamp, osmotic edema induced excitatory postsynaptic potentials and burst firing over the same timecourse as SICs. Like SICs, action potentials were blocked by NMDAR antagonists. Effects were more pronounced in adult (8-20 weeks old) compared with juvenile (P15-P21) mice. Together, our results indicate that cell swelling triggered by reduced osmolarity rapidly increases neuronal excitability through activation of NMDA receptors. Our findings have important implications for understanding nonsynaptic mechanisms of epilepsy in relation to cell swelling and reduction of the extracellular space. PMID:26489684

  15. Protocol for a randomised controlled trial of standard wound management versus negative pressure wound therapy in the treatment of adult patients with an open fracture of the lower limb: UK Wound management of Open Lower Limb Fractures (UK WOLFF)

    OpenAIRE

    Achten, Juul; Parsons, Nick R; Bruce, Julie; Petrou, Stavros; Tutton, Elizabeth; Willett, Keith; Lamb, Sarah E; Costa, Matthew L

    2015-01-01

    Introduction Patients who sustain open lower limb fractures have reported infection risks as high as 27%. The type of dressing applied after initial debridement could potentially affect this risk. In this trial, standard dressings will be compared with a new emerging treatment, negative pressure wound therapy, for patients with open lower limb fractures. Methods and analysis All adult patients presenting with an open lower limb fracture, with a Gustilo and Anderson (G&A) grade 2/3, will be co...

  16. Intrinsic properties of lumbar motor neurones in the adult G127insTGGG superoxide dismutase-1 mutant mouse in vivo: evidence for increased persistent inward currents

    DEFF Research Database (Denmark)

    Meehan, Claire Francesca; Moldovan, Mihai; Marklund, Stefan L.;

    2010-01-01

    lumbar motoneurones in the adult presymptomatic G127X mutant are not significantly different from those of wild type. However, at more depolarized membrane potentials, motoneurones in the G127X SOD1 mutants can sustain higher frequency firing, showing less spike frequency adaption and with persistent...... inward currents (PICs) being activated at lower firing frequencies and being more pronounced. Conclusion: We demonstrated that, in vivo, at resting membrane potential, spinal motoneurones of the adult G127X mice do not show an increased excitability. However, when depolarized they show evidence of an...

  17. Nuclear aspects of neutral current non-standard ν-nucleus reactions and the role of the exotic μ-→e- transitions experimental limits

    Science.gov (United States)

    Papoulias, D. K.; Kosmas, T. S.

    2014-01-01

    The nuclear aspects of flavour changing neutral current (FCNC) processes, predicted by various new-physics models to occur in the presence of nuclei, are examined by computing the relevant nuclear matrix elements within the context of the quasi-particle RPA using realistic strong two-body forces. One of our aims is to explore the role of the non-standard interactions (NSI) in the leptonic sector and specifically: (i) in lepton flavour violating (LFV) processes involving the neutral particles νℓ and ν, ℓ=e,μ,τ and (ii) in charged lepton flavour violating (cLFV) processes involving the charged leptons ℓ- or ℓ+. As concrete nuclear systems we have chosen the stopping targets of μ-→e- conversion experiments, i.e. the 48Ti nucleus of the PRIME/PRISM experiment at J-PARC and the 27Al of the COMET at J-PARC as well as of the Mu2e at Fermilab. These experiments have been designed to reduce the single event sensitivity down to 10-16-10-18 in searching for charged lepton mixing events. Our goal is, by taking advantage of our detailed nuclear structure calculations and using the present limits or the sensitivity of the aforementioned exotic μ-→e- experiments, to put stringent constraints on the parameters of NSI Lagrangians.

  18. [Anthropometric Indices Used for the Diagnosis of Malnutrition in Adolescents and Adults: Review of the Literature

    OpenAIRE

    Dorlencourt, F.; Priem, V; Legros, D

    2000-01-01

    The International Dietary Energy Consultative Group, sponsored by the World Health Organization (WHO), has done most of the research conducted in the field of adult malnutrition in the late 1980's. These studies were carried out mainly in populations suffering from chronic malnutrition, and led to the current WHO recommendations for the diagnosis and classification of adult malnutrition. Body Mass Index (BMI) is the gold standard to be used in adults, with the following cut-off points identif...

  19. Initial Studies Concerning the Current Status and Problems on the Formulation and Revision of the National Standards for Electric Insulation Materials

    Institute of Scientific and Technical Information of China (English)

    2004-01-01

    @@ Introduction After its accession to the WTO, China must establish an operational mechanism for the standardization work to meet the demands of domestic and foreign markets, and gradually perfect a standard system that meet the needs of national economy and social development.

  20. Training Standardization

    International Nuclear Information System (INIS)

    The article describes the benefits of and required process and recommendations for implementing the standardization of training in the nuclear power industry in the United States and abroad. Current Information and Communication Technologies (ICT) enable training standardization in the nuclear power industry. The delivery of training through the Internet, Intranet and video over IP will facilitate this standardization and bring multiple benefits to the nuclear power industry worldwide. As the amount of available qualified and experienced professionals decreases because of retirements and fewer nuclear engineering institutions, standardized training will help increase the number of available professionals in the industry. Technology will make it possible to use the experience of retired professionals who may be interested in working part-time from a remote location. Well-planned standardized training will prevent a fragmented approach among utilities, and it will save the industry considerable resources in the long run. It will also ensure cost-effective and safe nuclear power plant operation

  1. Radiotherapy of high-grade gliomas:current standards and new concepts, innovations in imaging and radiotherapy, and new therapeutic approaches

    Institute of Scientific and Technical Information of China (English)

    Frederic Dhermain

    2014-01-01

    The current standards in radiotherapy of high-grade gliomas (HGG) are based on anatomic imaging techniques, usually computed tomography (CT) scanning and magnetic resonance imaging (MRI). The guidelines vary depending on whether the HGG is a histological grade 3 anaplastic glioma (AG) or a grade 4 glioblastoma multiforme (GBM). For AG, T2-weighted MRI sequences plus the region of contrast enhancement in T1 are considered for the delineation of the gross tumor volume (GTV), and an isotropic expansion of 15 to 20 mm is recommended for the clinical target volume (CTV). For GBM, the Radiation Therapy Oncology Group favors a two-step technique, with an initial phase (CTV1) including any T2 hyperintensity area (edema) plus a 20 mm margin treated with up to 46 Gy in 23 fractions, followed by a reduction in CTV2 to the contrast enhancement region in T1 with an additional 25 mm margin. The European Organisation of Research and Treatment of Cancer recommends a single-phase technique with a unique GTV, which comprises the T1 contrast enhancement region plus a margin of 20 to 30 mm. A total dose of 60 Gy in 30 fractions is usual y delivered for GBM, and a dose of 59.4 Gy in 33 fractions is typical y given for AG. As more than 85% of HGGs recur in field, dose-escalation studies have shown that 70 to 75 Gy can be delivered in 6 weeks with relevant toxicities developing in60 Gy. Trials delivering a SIB into a biological GTV showed the feasibility of this treatment, but the final results, in terms of clinical benefits for HGG patients, are stil pending. Many issues have been identified: the variety of MRI and PET machines (and amino-acid tracers), the heterogeneity of the protocols used for image acquisition and post-treatment, the geometric distortion and the unreliable algorithms for co-registration of brain anatomy with functional maps, and the semi-quiescent but highly invasive HGG cells. These issues could be solved by the homogenization of the protocols and software

  2. Adult Cancers in Adolescents and Young Adults.

    Science.gov (United States)

    Laurence, Valérie; Marples, Maria; Stark, Daniel P

    2016-01-01

    The pattern of cancer seen in young people changes with increasing age, transitioning from childhood- to adult-type cancer in adolescence and the third decade. The risk factors, presentation and biology of cancer in young adults differ from those in the older adult population. Factors of particular significance in adolescents and young adults (AYAs) include genetic predisposition to adult-type cancer, diagnostic uncertainty, long-term morbidity and considerations of fertility. New systemic therapies are being introduced that can prolong life and even increase the chance of cure, but the impact on AYAs is uncertain, as these patients are often under-represented in clinical trials. Here, we discuss the management of AYAs with 3 of the most common cancers affecting adults, when they emerge in the AYA populations, and therefore are currently met by medical oncologists - breast cancer, colorectal cancer and melanoma. PMID:27595357

  3. Instant standard concept for data standards development

    OpenAIRE

    Folmer, Erwin; Kulcsor, Istvan Zsolt; Roes, Jasper

    2013-01-01

    This paper presents the current results of an ongoing research about a new data standards development concept. The concept is called Instant Standard referring to the pressure that is generated by shrinking the length of the standardization process. Based on this concept it is estimated that the development time is reduced by over 50% while maintaining an appropriate quality level for achieving interoperability in practice. The Instant Standard concept for development of data standards is des...

  4. NODC Standard Format Coastal Ocean Wave and Current (F181) Data from the Atlantic Remote Sensing Land/Ocean Experiment (ARSLOE) (1980) (NODC Accession 0014202)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — This data set contains time series coastal ocean wave and current data collected during the Atlantic Remote Sensing Land/Ocean Experiment (ARSLOE). ARSLOE was...

  5. NODC Standard Product: World Ocean Circulation Program (WOCE) Global Data, Version 2: Acoustic doppler current profilers data on CD-ROM (NODC Accession 0000312)

    Data.gov (United States)

    National Oceanic and Atmospheric Administration, Department of Commerce — World-Wide shipboard current data were collected from ADCP casts from the ALPHA HELIX and other platforms as part of World Ocean Circulation Experiment (WOCE). Data...

  6. Expression patterns of nicotinic subunits α2, α7, α8, and β1 affect the kinetics and pharmacology of ACh-induced currents in adult bee olfactory neuropiles.

    Science.gov (United States)

    Dupuis, Julien Pierre; Gauthier, Monique; Raymond-Delpech, Valérie

    2011-10-01

    Acetylcholine (ACh) is the main excitatory neurotransmitter of the insect brain, where nicotinic acetylcholine receptors (nAChRs) mediate fast cholinergic synaptic transmission. In the honeybee Apis mellifera, nAChRs are expressed in diverse structures including the primary olfactory centers of the brain, the antennal lobes (ALs) and the mushroom bodies (MBs), where they participate in olfactory information processing. To understand the nature and properties of the nAChRs involved in these processes, we performed a pharmacological and molecular characterization of nAChRs on cultured Kenyon cells of the MBs, using whole cell patch-clamp recordings combined with single-cell RT-PCR. In all cells, applications of ACh as well as nicotinic agonists such as nicotine and imidacloprid induced inward currents with fast desensitization. These currents were fully blocked by saturating doses of the antagonists α-bungarotoxin (α-BGT), dihydroxy-β-erythroidine (DHE), and methyllycaconitine (MLA) (MLA ≥ α-BGT ≥ DHE). Molecular analysis of ACh-responding cells revealed that of the 11 nicotinic receptor subunits encoded within the honeybee genome, α2, α8, and β1 subunits were expressed in adult Kenyon cells. Comparison with the expression pattern of adult AL cells revealed the supplementary presence of subunit α7, which could be responsible for the kinetic and pharmacological differences observed when comparing ACh-induced currents from AL and Kenyon cells. Together, our data demonstrate the existence of functional nAChRs on adult MB Kenyon cells that differ from nAChRs on AL cells in both their molecular composition and pharmacological properties, suggesting that changing receptor subsets could mediate different processing functions depending on the brain structure within the olfactory pathway. PMID:21734106

  7. When is birthweight at term abnormally low?: a systematic review and meta-analysis of the association and predictive ability of current birthweight standards for neonatal outcomes

    OpenAIRE

    Malin, G.L.; Morris, R K; Riley, R.; Teune, M.J.; Khan, K.S.

    2014-01-01

    Background Intrauterine growth restriction is a cause of neonatal morbidity and mortality. A variety of definitions of low birthweight are used in clinical practice, with a lack of consensus regarding which definitions best predict adverse outcomes. Objectives To evaluate the relationship between birthweight standards and neonatal outcome in term-born infants (at ≥ 37 weeks of gestation). Search strategy MEDLINE (1966–January 2011), EMBASE (1980–January 2011), and the Cochran...

  8. Quality of Survival and Growth in Children and Young Adults in the PNET4 European Controlled Trial of Hyperfractionated Versus Conventional Radiation Therapy for Standard-Risk Medulloblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Kennedy, Colin, E-mail: crk1@soton.ac.uk [University of Southampton Faculty of Medicine and University Hospital Southampton National Health Service Foundation Trust, Southampton (United Kingdom); Bull, Kim [University of Southampton Faculty of Medicine and University Hospital Southampton National Health Service Foundation Trust, Southampton (United Kingdom); Chevignard, Mathilde [Hôpitaux de Saint Maurice, Saint Maurice (France); Neurophysiology, University of Pierre et Marie-Curie Paris 6, Paris (France); Culliford, David [University of Southampton Faculty of Medicine and University Hospital Southampton National Health Service Foundation Trust, Southampton (United Kingdom); Dörr, Helmuth G. [Kinder- und Jugendklinik der Universität Erlangen, Erlangen (Germany); Doz, François [Institut Curie and University Paris Descartes, Sorbonne Paris Cité (France); Kortmann, Rolf-Dieter [Department of Radiation Therapy, University of Leipzig, Leipzig (Germany); Lannering, Birgitta [Department of Pediatrics, The Sahlgren Academy, University of Gothenburg, Gothenburg (Sweden); Massimino, Maura [Fondazione Istituto di Ricovero e Cura a Carattere Scientifico IRCCS Istituto Nazionale dei Tumori, Milan (Italy); Navajas Gutiérrez, Aurora [Hospital Universitario Cruces, Baracaldo-Vizcaya (Spain); Rutkowski, Stefan [University Medical Center Hamburg-Eppendorf, Hamburg (Germany); Spoudeas, Helen A. [Center for Pediatric Endocrinology, University College London, London (United Kingdom); Calaminus, Gabriele [Pediatric Oncology, University of Muenster, Muenster (Germany)

    2014-02-01

    Purpose: To compare quality of survival in “standard-risk” medulloblastoma after hyperfractionated radiation therapy of the central nervous system with that after standard radiation therapy, combined with a chemotherapy regimen common to both treatment arms, in the PNET4 randomised controlled trial. Methods and Materials: Participants in the PNET4 trial and their parents/caregivers in 7 participating anonymized countries completed standardized questionnaires in their own language on executive function, health status, behavior, health-related quality of life, and medical, educational, employment, and social information. Pre- and postoperative neurologic status and serial heights and weights were also recorded. Results: Data were provided by 151 of 244 eligible survivors (62%) at a median age at assessment of 15.2 years and median interval from diagnosis of 5.8 years. Compared with standard radiation therapy, hyperfractionated radiation therapy was associated with lower (ie, better) z-scores for executive function in all participants (mean intergroup difference 0.48 SDs, 95% confidence interval 0.16-0.81, P=.004), but health status, behavioral difficulties, and health-related quality of life z-scores were similar in the 2 treatment arms. Data on hearing impairment were equivocal. Hyperfractionated radiation therapy was also associated with greater decrement in height z-scores (mean intergroup difference 0.43 SDs, 95% confidence interval 0.10-0.76, P=.011). Conclusions: Hyperfractionated radiation therapy was associated with better executive function and worse growth but without accompanying change in health status, behavior, or quality of life.

  9. Quality of Survival and Growth in Children and Young Adults in the PNET4 European Controlled Trial of Hyperfractionated Versus Conventional Radiation Therapy for Standard-Risk Medulloblastoma

    International Nuclear Information System (INIS)

    Purpose: To compare quality of survival in “standard-risk” medulloblastoma after hyperfractionated radiation therapy of the central nervous system with that after standard radiation therapy, combined with a chemotherapy regimen common to both treatment arms, in the PNET4 randomised controlled trial. Methods and Materials: Participants in the PNET4 trial and their parents/caregivers in 7 participating anonymized countries completed standardized questionnaires in their own language on executive function, health status, behavior, health-related quality of life, and medical, educational, employment, and social information. Pre- and postoperative neurologic status and serial heights and weights were also recorded. Results: Data were provided by 151 of 244 eligible survivors (62%) at a median age at assessment of 15.2 years and median interval from diagnosis of 5.8 years. Compared with standard radiation therapy, hyperfractionated radiation therapy was associated with lower (ie, better) z-scores for executive function in all participants (mean intergroup difference 0.48 SDs, 95% confidence interval 0.16-0.81, P=.004), but health status, behavioral difficulties, and health-related quality of life z-scores were similar in the 2 treatment arms. Data on hearing impairment were equivocal. Hyperfractionated radiation therapy was also associated with greater decrement in height z-scores (mean intergroup difference 0.43 SDs, 95% confidence interval 0.10-0.76, P=.011). Conclusions: Hyperfractionated radiation therapy was associated with better executive function and worse growth but without accompanying change in health status, behavior, or quality of life

  10. Instant standard concept for data standards development

    NARCIS (Netherlands)

    Folmer, E.; Kulcsar, I.Z.; Roes, J.

    2013-01-01

    This paper presents the current results of an ongoing research about a new data standards development concept. The concept is called Instant Standard referring to the pressure that is generated by shrinking the length of the standardization process. Based on this concept it is estimated that the dev

  11. 78 FR 23260 - Request for Measures and Domains To Use in Development of a Standardized Instrument for Use in...

    Science.gov (United States)

    2013-04-18

    ... Development of a Standardized Instrument for Use in Public Reporting of the Quality of Transition From Child... transition from pediatric to adult health care. The goal is to develop a standardized instrument for use in...); --Results of cognitive testing; --Results of field-testing; --Current use of the instrument (who is using...

  12. Current and proposed revisions, changes, and modifications to American codes and standards to address packaging, handling, and transportation of radioactive materials and how they relate to comparable international regulations

    International Nuclear Information System (INIS)

    This paper addresses current and proposed revisions, additions, and modifications to American Society of Mechanical Engineers (ASME) Boiler and Pressure Vessel Code (BPVC) (i.e., ''ASMEthe Code'') Section III, Division 3 and American National Standards Institute (ANSI)/ASME N14.6. It provides insight into the ongoing processes of the associated committees and highlights important revisions, changes, and modifications to this Code and Standard. The ASME Code has developed and issued Division 3 to address items associated with the transportation and storage of radioactive materials. It currently only addresses ''General Requirements'' in Subsections WA and ''Class TP (Type B) Containments'' (Transportation Packages) in Subsection WB, but is in the process of adding a new Subsection WC to address ''Class SC'' (Storage Containments). ANSI/ASME Standard N14.6 which interacts with components constructed to Division 3 by addressinges special lifting devices for radioactive material shipping containers. This Standard is in the process of a complete re-write. This Code and Standard can be classified as ''dynamic'' in that their committees meet at least four times a year to evaluate proposed modifications and additions that reflect current safety practices in the nuclear industry. These evaluations include the possible addition of new materials, fabrication processes, examination methods, and testing requirements. An overview of this ongoing process is presented in this paper along with highlights of the more important proposed revisions, changes, and modifications and how they relate to United States (US) and international regulations and guidance like International Atomic Energy Agency (IAEA) Requirement No. TS-R-1

  13. Effects of standard training in the use of closed-circuit televisions in visually impaired adults: design of a training protocol and a randomized controlled trial

    Directory of Open Access Journals (Sweden)

    van Rens Ger HMB

    2010-03-01

    Full Text Available Abstract Background Reading problems are frequently reported by visually impaired persons. A closed-circuit television (CCTV can be helpful to maintain reading ability, however, it is difficult to learn how to use this device. In the Netherlands, an evidence-based rehabilitation program in the use of CCTVs was lacking. Therefore, a standard training protocol needed to be developed and tested in a randomized controlled trial (RCT to provide an evidence-based training program in the use of this device. Methods/Design To develop a standard training program, information was collected by studying literature, observing training in the use of CCTVs, discussing the content of the training program with professionals and organizing focus and discussion groups. The effectiveness of the program was evaluated in an RCT, to obtain an evidence-based training program. Dutch patients (n = 122 were randomized into a treatment group: normal instructions from the supplier combined with training in the use of CCTVs, or into a control group: instructions from the supplier only. The effect of the training program was evaluated in terms of: change in reading ability (reading speed and reading comprehension, patients' skills to operate the CCTV, perceived (vision-related quality of life and tasks performed in daily living. Discussion The development of the CCTV training protocol and the design of the RCT in the present study may serve as an example to obtain an evidence-based training program. The training program was adjusted to the needs and learning abilities of individual patients, however, for scientific reasons it might have been preferable to standardize the protocol further, in order to gain more comparable results. Trial registration http://www.trialregister.nl, identifier: NTR1031

  14. Adult Strabismus

    Science.gov (United States)

    ... Conditions Frequently Asked Questions Español Condiciones Chinese Conditions Adult Strabismus En Español Read in Chinese Can anything be done for adults with strabismus (misaligned eyes)? Yes. Adults can benefit ...

  15. Guidelines for the Design and Conduct of Clinical Studies in Knee Articular Cartilage Repair: International Cartilage Repair Society Recommendations Based on Current Scientific Evidence and Standards of Clinical Care

    OpenAIRE

    Mithoefer, Kai; Saris, Daniel B.F.; Farr, Jack; Kon, Elizaveta; Zaslav, Kenneth; Cole, Brian J.; Ranstam, Jonas; Yao, Jian; Shive, Matthew; Levine, David; Dalemans, Wilfried; Brittberg, Mats

    2011-01-01

    Objective: To summarize current clinical research practice and develop methodological standards for objective scientific evaluation of knee cartilage repair procedures and products. Design: A comprehensive literature review was performed of high-level original studies providing information relevant for the design of clinical studies on articular cartilage repair in the knee. Analysis of cartilage repair publications and synopses of ongoing trials were used to identify important criteria for t...

  16. RESULTS OF TESTS OF LIGHTNING-RODS WITH UNIVERSAL CLAMPS BY THE APERIODIC IMPULSES OF CURRENT OF ARTIFICIAL LIGHTNING WITH THE PEAK-TEMPORAL PARAMETERS RATIONED ON FOREIGN STANDARDS

    Directory of Open Access Journals (Sweden)

    M.I. Baranov

    2015-06-01

    Full Text Available Purpose. Test in obedience to the requirements of row of operating foreign standards of round metallic lightning-rods with the flat metallic universal clamps of the special type on firmness to direct action of аperiodic impulses of current of temporal form 10/350 μs by amplitude of 50 кА (N− class and 100 кА (H− class. Methodology. The order of leadthrough of these tests is certain the followings normative documents: International IEC 62305-1: 2010, Russian national GOST R IEC 62305-1-2010 and German national DIN EN 50164-1:2008 Standards. Results. Conducted on a powerful high-voltage pulsed current of artificial linear lightning with the peak-temporal parameters and admittances of test rationed on the indicated foreign standards rationed that all of the lightning-rods tested in collection with universal clamps, isolating holders and ceramic elements of roof of technical building were survive electrodynamics and electrothermal action of in-use single short blow of an artificial storm digit. Originality. First in domestic practice the similar model tests of lightning-rods are conducted with universal clamps, executed from different explorer materials, on firmness to flowing to on by it the indicated large impulsive currents of artificial lightning. Practical value. Real firmness to lightning of round copper and zincked steel lightning-rods is certain with the flat copper, zincked steel and non-rusting steel universal clamps of the special execution.

  17. Higher Early Monocyte and Total Lymphocyte Counts Are Associated with Better Overall Survival after Standard Total Body Irradiation, Cyclophosphamide, and Fludarabine Reduced-Intensity Conditioning Double Umbilical Cord Blood Allogeneic Stem Cell Transplantation in Adults.

    Science.gov (United States)

    Le Bourgeois, Amandine; Peterlin, Pierre; Guillaume, Thierry; Delaunay, Jacques; Duquesne, Alix; Le Gouill, Steven; Moreau, Philippe; Mohty, Mohamad; Campion, Loïc; Chevallier, Patrice

    2016-08-01

    This single-center retrospective study aimed to report the impact of early hematopoietic and immune recoveries after a standard total body irradiation, cyclophosphamide, and fludarabine (TCF) reduced-intensity conditioning (RIC) regimen for double umbilical cord blood (dUCB) allogeneic stem cell transplantation (allo-SCT) in adults. We analyzed 47 consecutive patients older than 17 years who engrafted after a dUCB TCF allo-SCT performed between January 2006 and April 2013 in our department. Median times for neutrophil and platelet recoveries were 17 (range, 6 to 59) and 37 days (range, 0 to 164), respectively. The 3-year overall (OS) and disease-free survivals, relapse incidence, and nonrelapse mortality were 65.7%, 57.2%, 27.1%, and 19%, respectively. In multivariate analysis, higher day +30 monocyte (≥615/mm(3); hazard ratio [HR], .04; 95% confidence interval [CI], .004 to .36; P < .01) and day +42 lymphocyte (≥395/mm(3); HR, .16; 95% CI, .03 to .78; P = .02) counts were independently associated with better OS. These results suggest that early higher hematopoietic and immune recovery is predictive of survival after dUCB TCF RIC allo-SCT in adults. Factors other than granulocyte colony-stimulating factor, which was used in all cases, favoring expansion of monocytes or lymphocytes, should be tested in the future as part of the UCB transplantation procedure. PMID:27118570

  18. Prevalence of Psychological Trauma and Association with Current Health and Functioning in a Sample of HIV-Infected and HIV-Uninfected Tanzanian Adults.

    OpenAIRE

    Pence, Brian W.; Kristen Shirey; Kathryn Whetten; Bernard Agala; Dafrosa Itemba; Julie Adams; Rachel Whetten; Jia Yao; John Shao

    2012-01-01

    Background In high income nations, traumatic life experiences such as childhood sexual abuse are much more common in people living with HIV/AIDS (PLWHA) than the general population, and trauma is associated with worse current health and functioning. Virtually no data exist on the prevalence or consequences of trauma for PLWHA in low income nations. Methodology/Principal Findings We recruited four cohorts of Tanzanian patients in established medical care for HIV infection (n = 228), individual...

  19. 我国现行会计准则存在的问题及对策研究%The Problems of China's Current Accounting Standards and Countermeasures

    Institute of Scientific and Technical Information of China (English)

    于婧婧

    2014-01-01

    China's accounting standards now have some problems. The defined scopes of the assets need to extend and divide meticulous-ly. The vague provisions of contingent amounts payable need to confirm following the principle of prudence principle of accounting. The use of fair value needs to adopt prudence principle and consider the actual. Facing the problems of identification of non-monetary assets exchange and tax, accounting standards should give an accurate concept and definition, so as to make up for the deficiency.%目前,我国会计准则中资产的界定范围、或有事项处理、公允价值计量与非货币性资产交换等方面存在的问题主要是对资产的定义有待扩展,进行细致划分;或有应付金额确认的规定存在模糊,应该遵照会计的谨慎性原则进行确认;对公允价值的运用既要采用谨慎性原则,还要考虑实际;在处理非货币的资产交换认定和税费的问题时,会计准则应给出一个准确的概念和定义,进而补充各项会计准则的不足之处。

  20. Superallowed 0+→0+ nuclear β decays: A critical survey with tests of the conserved vector current hypothesis and the standard model

    International Nuclear Information System (INIS)

    A complete and critical survey is presented of all half-life, decay-energy, and branching-ratio measurements related to 20 superallowed 0+→0+ decays; no measurements are ignored, although some are rejected for cause and others updated. A new calculation of the statistical rate function f is described and experimental ft values determined. The associated theoretical corrections needed to convert these results into 'corrected' Ft values are discussed, and careful attention is paid to the origin and magnitude of their uncertainties. As an exacting confirmation of the conserved vector current hypothesis, the corrected Ft values are seen to be constant to three parts in 104. These data are also used to set a new limit on any possible scalar interaction (assuming maximum parity violation) of CS/CV=-(0.00005±0.00130). The average Ft value obtained from the survey, when combined with the muon lifetime, yields the up-down quark-mixing element of the Cabibbo-Kobayashi-Maskawa (CKM) matrix, Vud=0.9738±0.0004, and the unitarity test on the top row of the matrix becomes vertical bar Vud vertical bar2+ vertical bar Vus vertical bar2+ vertical bar Vub vertical bar2=0.9966±0.0014 using the Particle Data Group's currently recommended values for Vus and Vub. If Vus comes instead from two recent results on Ke3 decay, the unitarity sum becomes 0.9996(11). Either result can be expressed in terms of the possible existence of right-hand currents. Finally, we discuss the priorities for future theoretical and experimental work with the goal of making the CKM unitarity test more definitive

  1. Diagnostic accuracy of MRI in adults with suspect brachial plexus lesions: A multicentre retrospective study with surgical findings and clinical follow-up as reference standard

    Energy Technology Data Exchange (ETDEWEB)

    Tagliafico, Alberto, E-mail: alberto.tagliafico@unige.it [Institute of Anatomy, Department of Experimental Medicine, University of Genoa, Largo Rosanna Benzi 8, 16132 Genoa (Italy); Succio, Giulia; Serafini, Giovanni [Department of Radiology, Santa Corona Hospital, Pietra Ligure, Italy via XXV Aprile, 38- Pietra Ligure, 17027 Savona (Italy); Martinoli, Carlo [Radiology Department, DISC, Università di Genova, Largo Rosanna Benzi 8, 16138 Genova (Italy)

    2012-10-15

    Objective: To evaluate brachial plexus MRI accuracy with surgical findings and clinical follow-up as reference standard in a large multicentre study. Materials and methods: The research was approved by the Institutional Review Boards, and all patients provided their written informed consent. A multicentre retrospective trial that included three centres was performed between March 2006 and April 2011. A total of 157 patients (men/women: 81/76; age range, 18–84 years) were evaluated: surgical findings and clinical follow-up of at least 12 months were used as the reference standard. MR imaging was performed with different equipment at 1.5 T and 3.0 T. The patient group was divided in five subgroups: mass lesion, traumatic injury, entrapment syndromes, post-treatment evaluation, and other. Sensitivity, specificity with 95% confidence intervals (CIs), positive predictive value (PPV), pre-test-probability (the prevalence), negative predictive value (NPV), pre- and post-test odds (OR), likelihood ratio for positive results (LH+), likelihood ratio for negative results (LH−), accuracy and post-test probability (post-P) were reported on a per-patient basis. Results: The overall sensitivity and specificity with 95% CIs were: 0.810/0.914; (0.697–0.904). Overall PPV, pre-test probability, NPV, LH+, LH−, and accuracy: 0.823, 0.331, 0.905, 9.432, 0.210, 0.878. Conclusions: The overall diagnostic accuracy of brachial plexus MRI calculated on a per-patient base is relatively high. The specificity of brachial plexus MRI in patients suspected of having a space-occupying mass is very high. The sensitivity is also high, but there are false-positive interpretations as well.

  2. Diagnostic accuracy of MRI in adults with suspect brachial plexus lesions: A multicentre retrospective study with surgical findings and clinical follow-up as reference standard

    International Nuclear Information System (INIS)

    Objective: To evaluate brachial plexus MRI accuracy with surgical findings and clinical follow-up as reference standard in a large multicentre study. Materials and methods: The research was approved by the Institutional Review Boards, and all patients provided their written informed consent. A multicentre retrospective trial that included three centres was performed between March 2006 and April 2011. A total of 157 patients (men/women: 81/76; age range, 18–84 years) were evaluated: surgical findings and clinical follow-up of at least 12 months were used as the reference standard. MR imaging was performed with different equipment at 1.5 T and 3.0 T. The patient group was divided in five subgroups: mass lesion, traumatic injury, entrapment syndromes, post-treatment evaluation, and other. Sensitivity, specificity with 95% confidence intervals (CIs), positive predictive value (PPV), pre-test-probability (the prevalence), negative predictive value (NPV), pre- and post-test odds (OR), likelihood ratio for positive results (LH+), likelihood ratio for negative results (LH−), accuracy and post-test probability (post-P) were reported on a per-patient basis. Results: The overall sensitivity and specificity with 95% CIs were: 0.810/0.914; (0.697–0.904). Overall PPV, pre-test probability, NPV, LH+, LH−, and accuracy: 0.823, 0.331, 0.905, 9.432, 0.210, 0.878. Conclusions: The overall diagnostic accuracy of brachial plexus MRI calculated on a per-patient base is relatively high. The specificity of brachial plexus MRI in patients suspected of having a space-occupying mass is very high. The sensitivity is also high, but there are false-positive interpretations as well

  3. The Current Banking Industry Civilized Norms Service Demonstration Unit With the Correct Evaluation Standard%现行银行业文明规范服务示范单位考核标准的评价与矫正

    Institute of Scientific and Technical Information of China (English)

    张翠翠

    2014-01-01

    The current bank of civilized service demonstration unit standards questionable places a lot of. In this paper, ifnd out the shortage of the current service standards through the national banking has to carry out a speciifc analysis and evaluation, put forward the bank civilized service demonstration unit standard correction view, deals with the formulation and evaluation standard of perfection of the principle is:to be practical and realistic attitude, pragmatic style of work, the idea of scientiifc development, characteristic and the demand of the customer for the the banking industry to design and make the evaluation standard, the only way is responsible for the development of China's banking sector.%现行的银行文明服务示范单位标准值得商榷的地方很多。本文通过找出目前全国银行业服务标准存在的不足来进行了具体分析和评价,提出了银行文明服务示范单位标准的矫正观点,阐述了制定和完善评价标准的原则是:要以实事求是的态度,务实的作风,科学发展的思想,针对银行业的特点和客户的实际需求来设计制定考核评价标准,只有这样才是对中国银行业发展负责。

  4. Repeated vertebral augmentation for new vertebral compression fractures of postvertebral augmentation patients: a nationwide cohort study – how useful is the current clinical gold standard for fracture risk?

    Directory of Open Access Journals (Sweden)

    Wilson HCP

    2015-10-01

    Full Text Available Hannah CP Wilson,1 Paul D Abel,2 S Imran A Shah2 1Department of Post-graduate Students, Imperial College London, Charing Cross Hospital, 2Department of surgery and cancer, Imperial College London, Hammersmith Hospital, London, UKFurther to the recent publication on the “Repeated vertebral augmentation for new vertebral compression fractures of postvertebral augmentation patients: a nationwide cohort study”,1 current data highlight the limitations of dual-energy X-ray absorptiometry scans. In this context, at best, dual-energy X-ray absorptiometry scans (which measure bone mineral density can account for no greater than 50% of overall bone strength (defined as the ability to resist fracture. This is because the resulting images are two-dimensional and therefore unable to capture skeletal micro-architecture, which also contributes to bone strength.2 View original article by Liang et al 

  5. Changes in synaptic and extrasynaptic N-methyl-D-aspartate receptor-mediated currents at early-stage epileptogenesis in adult mice

    Institute of Scientific and Technical Information of China (English)

    Juegang Ju; Sheng-tian Li

    2011-01-01

    Previous reports have shown that N-methyl-D-aspartate (NMDA) receptors are extensively involved in epilepsy genesis and recurrence.Recent studies have shown that synaptic and extrasynaptic NMDA receptors play different, or even opposing, roles in various signaling pathways, including synaptic plasticity and neuronal death.The present study analyzed changes in synaptic and extrasynaptic NMDA receptor-mediated currents during epilepsy onset.Mouse models of lithium chloride pilocarpine-induced epilepsy were established, and hippocampal slices were prepared at 24 hours after the onset of status epilepticus.Synaptic and extrasynaptic NMDA receptor-mediated excitatory post-synaptic currents (NMDA-EPSCs) were recorded in CA1 pyramidal neurons by whole-cell patch clamp technique.Results demonstrated no significant difference in rise and delay time of synaptic NMDA-EPSCs compared with normal neurons.Peak amplitude, area-to-peak ratio,and rising time of extrasynaptic NMDA-EPSCs remained unchanged, but decay of extrasynaptic NMDA-EPSCs was faster than that of normal neurons.These results suggest that extrasynaptic NMDA receptors play a role in epileptogenesis.

  6. 机载软件适航认证标准新进展及展望%Current progress and prospects of airworthiness certification standards in airborne software

    Institute of Scientific and Technical Information of China (English)

    郑军; 黄志球; 徐丙凤

    2012-01-01

    为了满足机载软件适航认证的迫切需求,对机载软件适航认证标准进行分析研究.阐述了DO-178B的发展动因及过程,总结了随着软件开发技术的快速更新DO-178B所表现的不足.说明了对DO-178B进行更新的必要性,并将即将发布的新版本DO-178C与DO-178B进行了对比.根据对比结果重点分析了DO-178C的4个新增特性.对DO-178C所带来的影响以及未来应用进行了展望.%To meet the urgent need of airworthiness certification on airborne software, airworthiness certification standards on airborne software are analyzed. Firstly, the development motivation and process of DO-178B are provided, and the deficiencies of DO-178B in the case of the rapid update of software technology and methods are summarized. Secondly, the necessity of updating DO-178B is pointed out, and a comparison between DO178C which will be published in the near future and DO178B is made. On the foundation of comparison, four new features of DO-178C are analyzed emphatically. Finally, the future prospect of the impaction and application of DO-178C are proposed.

  7. Comparison of Immunogenicity of Low-Dose Intradermal Hepatitis B Vaccine with the Standard-Dose Intramuscular Vaccination in Young Healthy Iranian Adults

    Directory of Open Access Journals (Sweden)

    Batool Sharifi-Mood

    2008-05-01

    Full Text Available Background and Aims: Although hepatitis B vaccine reliably induces immunity against hepatitis B virus (HBV, the cost of intramuscular (IM vaccination has limited its use, particularly in many developing countries. Intradermal (ID vaccination has been proposed as a cost-saving alternative method for administration of hepatitis B vaccine. However, the effectiveness of ID vaccination needs to be assessed in different ethnic groups. Methods: From September 2006 to March 2008, 185 healthy anti-HBc-negative medical and nursing students at Zahedan University of Medical Sciences who had no history of vaccination against HBV, smoking or hepatitis were evaluated. They were randomly categorized into two groups. In group I (n=91, low-dose (4 |mg recombinant hepatitis B vaccine (Euvax B, Korea was given by intradermal route. In group II (n=94, the standard dose (20 mg of the vaccine was administered intramuscularly at 0, 1, and 6 months. The groups were followed for a minimum of 7 months after the first vaccine dose and tested for anti-HBs titers by ELISA (Diasorin Bio Medica Kit, Saluugia, Italy.Results: Seroprotective anti-HBs titers (titer >10 mIU/mL were achieved in 79 (87% students in group I and in 90 (96% in group II (P=0.031. The difference was much pronounced when the two groups were compared for achieving an anti-HBs titer >300 mIU/mL (P<0.0001.Conclusions: Although ID administration of 4-mg recombinant hepatitis B vaccine is effective, this route is less effective with lower immune response than the IM vaccination.

  8. Young Adult Smoking Behavior

    Science.gov (United States)

    Ling, Pamela M.; Neilands, Torsten B.; Glantz, Stanton A.

    2009-01-01

    Background Young adults have the highest smoking rate of any age group in the U.S., and new strategies to decrease young adult smoking are needed. The objective of the current study was to identify psychographic and demographic factors associated with current smoking and quitting behaviors among young adults. Methods Attitudes, social groups, and self-descriptors, including supporting action against the tobacco industry, advertising receptivity, depression, alcohol use, and other factors associated with smoking were tested for associations with smoking behaviors in a 2005 cross-sectional survey of 1528 young adults (aged 18–25 years) from a web-enabled panel. Analyses were conducted in 2007. Results Being older was associated with current smoking, whereas having some higher education and being African American or Hispanic were negatively associated with smoking. Supporting action against the tobacco industry was negatively associated with smoking (AOR=0.34 [95% CI=0.22, 0.52]). Perceived usefulness of smoking, exposure to smokers, increased perceived smoking prevalence, receptivity to tobacco advertising, binge drinking, and exposure to tobacco advertising in bars and clubs were associated with smoking. Supporting action against the tobacco industry was associated with intentions to quit smoking (AOR= 4.43 [95% CI=2.18, 8.60]). Conclusions Young adults are vulnerable to tobacco-industry advertising. Media campaigns that denormalize the tobacco industry and appeal to young adults appear to be a powerful intervention to decrease young adult smoking. PMID:19269128

  9. Estimated use of abacavir among adults and children enrolled in public sector antiretroviral therapy programmes in Gauteng, South Africa

    Directory of Open Access Journals (Sweden)

    D Evans

    2012-09-01

    Full Text Available In South Africa, abacavir (ABC is currently recommended as part of first- and second-line antiretroviral therapy (ART for HIV-positive paediatric patients. Concerns about overprescribing of the drug, particularly to adults, led to an analysis of ABC use in public sector ART programmes. We investigated current prescription of the drug to adults and children accessing ART in 4 public sector programmes across Gauteng Province, South Africa. ABC was almost exclusively prescribed to children initiating ART and adults requiring regimen changes due to drug toxicities. Patterns of ABC use among HIV-positive paediatric patients followed national ART treatment guidelines on the application of the drug. Although ABC is commonly used in the private sector for adults, the current national ART treatment guidelines for adults and adolescents should include ABC as an alternative to standard first- or second-line ART.

  10. Adult Education and Adult Learning

    DEFF Research Database (Denmark)

    Illeris, Knud

    Kort beskrivelse Bogen, 'Adult Education og Adult Learning', giver et fyldestgørende overblik over forståelsen af voksenuddannelse og læring. Abstract I "Adult Education and Adult Learning' ser Knud Illeris på voksenuddannelse fra to perspektiver. På den ene side beskrives de aktuelle udfordringer...

  11. Accuracy of Functional and Predictive Methods to Calculate the Hip Joint Center in Young Non-pathologic Asymptomatic Adults with Dual Fluoroscopy as a Reference Standard.

    Science.gov (United States)

    Fiorentino, Niccolo M; Kutschke, Michael J; Atkins, Penny R; Foreman, K Bo; Kapron, Ashley L; Anderson, Andrew E

    2016-07-01

    Predictions from biomechanical models of gait may be sensitive to joint center locations. Most often, the hip joint center (HJC) is derived from locations of reflective markers adhered to the skin. Here, predictive techniques use regression equations of pelvic anatomy to estimate the HJC, whereas functional methods track motion of markers placed at the pelvis and femur during a coordinated motion. Skin motion artifact may introduce errors in the estimate of HJC for both techniques. Quantifying the accuracy of these methods is an area of open investigation. In this study, we used dual fluoroscopy (DF) (a dynamic X-ray imaging technique) and three-dimensional reconstructions from computed tomography images, to measure HJC locations in vivo. Using dual fluoroscopy as the reference standard, we then assessed the accuracy of three predictive and two functional methods. Eleven non-pathologic subjects were imaged with DF and reflective skin marker motion capture. Additionally, DF-based solutions generated virtual markers placed on bony landmarks, which were input to the predictive and functional methods to determine if estimates of the HJC improved. Using skin markers, functional methods had better mean agreement with the HJC measured by DF (11.0 ± 3.3 mm) than predictive methods (18.1 ± 9.5 mm); estimates from functional and predictive methods improved when using the DF-based solutions (1.3 ± 0.9 and 17.5 ± 8.6 mm, respectively). The Harrington method was the best predictive technique using both skin markers (13.2 ± 6.5 mm) and DF-based solutions (10.6 ± 2.5 mm). The two functional methods had similar accuracy using skin makers (11.1 ± 3.6 and 10.8 ± 3.2 mm) and DF-based solutions (1.2 ± 0.8 and 1.4 ± 1.0 mm). Overall, functional methods were superior to predictive methods for HJC estimation. However, the improvements observed when using the DF-based solutions suggest that skin motion artifact is a large source of error for the

  12. The Current Situation of China's Peat industry and the Development of Peat Standardization%浅论我国泥炭产业现状及泥炭标准化发展

    Institute of Scientific and Technical Information of China (English)

    闫木林

    2011-01-01

    本文阐述了国内和国外泥炭产业的发展现状,分析了泥炭产业对发展循环经济,促进可持续发展的重要性和泥炭产业发展的资源、环境问题,以及现今泥炭标准化的发展现状.指出了我国泥炭行业标准化存在的问题,并提出了相应发展方向和对策.%In this paper, domestic and foreign industry development in peat, peat industry analysis for thedevelopment of recycling economy and promote the importance of sustainable development, industrialdevelopment and peat resources, environmental issues, as well as standardization of the current developmentstatus of peat. That the peat industry standardization of China's problems, and the corresponding direction andstrategies.

  13. Changes in smoking prevalence among U.S. adults by state and region: Estimates from the Tobacco Use Supplement to the Current Population Survey, 1992-2007

    Directory of Open Access Journals (Sweden)

    Center Melissa M

    2011-06-01

    Full Text Available Abstract Background Tobacco control policies at the state level have been a critical impetus for reduction in smoking prevalence. We examine the association between recent changes in smoking prevalence and state-specific tobacco control policies and activities in the entire U.S. Methods We analyzed the 1992-93, 1998-99, and 2006-07 Tobacco Use Supplement to the Current Population Survey (TUS-CPS by state and two indices of state tobacco control policies or activities [initial outcome index (IOI and the strength of tobacco control (SOTC index] measured in 1998-1999. The IOI reflects cigarette excise taxes and indoor air legislation, whereas the SOTC reflects tobacco control program resources and capacity. Pearson Correlation coefficient between the proportionate change in smoking prevalence from 1992-93 to 2006-07 and indices of tobacco control activities or programs was the main outcome measure. Results Smoking prevalence decreased from 1992-93 to 2006-07 in both men and women in all states except Wyoming, where no reduction was observed among men, and only a 6.9% relative reduction among women. The percentage reductions in smoking in men and women respectively were the largest in the West (average decrease of 28.5% and 33.3% and the smallest in the Midwest (18.6% and 20.3%, although there were notable exceptions to this pattern. The decline in smoking prevalence by state was correlated with the state's IOI in both women and men (r = -0.49, p Conclusion State level policies on cigarette excise taxes and indoor air legislation correlate strongly with reductions in smoking prevalence since 1992. Strengthening and systematically implementing these policies could greatly accelerate further reductions in smoking.

  14. Engaging the Adult Learner Generational Mix

    Science.gov (United States)

    Holyoke, Laura; Larson, Erick

    2009-01-01

    Educators and Trainers both focus on adult learning theory when teaching. In the workforce, as well as in higher education, current literature pertaining to adult learners tends to lump all adults into the same category. Scant research exists that reviews the adult learner through a generational lens. This paper examines the elements that engage…

  15. Becoming adult educators in Denmark

    DEFF Research Database (Denmark)

    Milana, Marcella; Søgaard Lund, Lise

    2009-01-01

    In this paper we present an analysis of identity-construction processes among adult educators in Denmark and we address the question how adult educators develop professionalism, not least by taking advantage of existing opportunity structures for current and prospective adult educators. A between......-cases analysis of fifteen narrative interviews explores the professional pathways towards adult education, the perceived images of a (professional) adult educator, processes of identification with concrete or imaginary communities, and motivation for adult educator to enrol in current opportunity structures to...... better qualify as professionals. The findings suggest that identity-building among Danish adult educators fluctuates between several processes of identification with either concrete or imaginary communities to which they relate at home, at work etc., but which do not necessarily result from a strong...

  16. The Autism Diagnostic Observation Schedule, Module 4: Revised Algorithm and Standardized Severity Scores

    Science.gov (United States)

    Hus, Vanessa; Lord, Catherine

    2014-01-01

    The recently published Autism Diagnostic Observation Schedule, 2nd edition (ADOS-2) includes revised diagnostic algorithms and standardized severity scores for modules used to assess younger children. A revised algorithm and severity scores are not yet available for Module 4, used with verbally fluent adults. The current study revises the Module 4…

  17. Serological diagnosis of toxoplasmosis and standardization.

    Science.gov (United States)

    Zhang, Kuo; Lin, Guigao; Han, Yanxi; Li, Jinming

    2016-10-01

    Humans can be infected by the intracellular parasite Toxoplasma gondii, which causes toxoplasmosis, a common parasitic disease. Although the infection is generally asymptomatic for most adults, severe complications may occur in some individuals, especially women in early pregnancy. Serologic diagnosis is used as a routine practice to determine the immune status for infection by T. gondii. In this review, we attempt to provide an overview of the serological diagnosis of toxoplasmosis, including diagnostic strategy, current problems in detection with specific antibodies, and the standardization of T. gondii serological detection. PMID:27470936

  18. DOE technical standards list: Department of Energy standards index

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1999-05-01

    This Department of Energy (DOE) technical standards list (TSL) has been prepared by the Office of Nuclear Safety Policy and Standards (EH-31) on the basis of currently available technical information. Periodic updates of this TSL will be issued as additional information is received on standardization documents being issued, adopted, or canceled by DOE. This document was prepared for use by personnel involved in the selection and use of DOE technical standards and other Government and non-Government standards. This TSL provides listings of current DOE technical standards, non-Government standards that have been adopted by DOE, other standards-related documents in which DOE has a recorded interest, and canceled DOE technical standards. Information on new DOE technical standards projects, technical standards released for coordination, recently published DOE technical standards, and activities of non-Government standards bodies that may be of interest to DOE is published monthly in Standards Actions.

  19. Service Providers' Perceptions of Active Ageing among Older Adults with Lifelong Intellectual Disabilities

    Science.gov (United States)

    Buys, L.; Aird, R.; Miller, E.

    2012-01-01

    Background: Considerable attention is currently being directed towards both active ageing and the revising of standards for disability services within Australia and internationally. Yet, to date, no consideration appears to have been given to ways to promote active ageing among older adults with intellectual disabilities (IDs). Methods:…

  20. Older Adults and Food Safety

    Science.gov (United States)

    ... Standard Forms FSIS United States Department of Agriculture Food Safety and Inspection Service About FSIS District Offices Careers ... JSR 286) Actions ${title} Loading... Older Adults and Food Safety An adage states, "With age, comes wisdom." Hopefully ...

  1. 成人注意力缺陷/多动障碍的流行病学研究和药物治疗进展%Epidemiology and Pharmacotherapy of Adult Attention Deifcit/Hyperactivity Disorder:Current Status

    Institute of Scientific and Technical Information of China (English)

    刘治军

    2012-01-01

    注意力缺陷/多动障碍(attention deficit/hyperactivity disorder,ADHD)是儿童常见的神经发育异常疾病,大多数儿童期ADHD将持续带入到成人期。2012年由美国精神病学协会颁布的DSM-5首次给出了成人ADHD的诊断,规范了成人ADHD的治疗。目前主要的治疗药物包括哌甲酯、苯丙胺类神经兴奋剂类、托莫西汀、安非他酮和三环类抗抑郁药等非兴奋剂类,其它药物如文拉法辛、瑞波西汀、莫达非尼、奥卡西平、普萘洛尔等也被尝试用于治疗成人ADHD,并取得一定疗效。%Attention deficit/hyperactivity disorder(ADHD)is the most frequently diagnosed neuro-developmental disorder in children and most of the children ADHD cases can persist to adulthood. The DSM-5 developed and published by American Psychiatric Association(APA)at 2012 firstly gives the more appropriate diagnosis criteria and regulates pharmacotherapies for adult ADHD. The currently used medications include neural stimulants(e.g. methylphenidate and amphetamines)and non-stimulants(e.g. atomoxetine,buproprion and tricyclic antidepressants). Other medications such as venlafaxine,reboxetine,modafinil,oxcarbazepine and propranolol are also tried to treat adult ADHD and showed a certain effects.

  2. Modern Biotechnology—Current Standards in Japan

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    @@In the past few years, a new technology, biotechnology, has come into practical use internationally. It is prospective that application of biotechnology in the field of food production may lead to improved food quality and productivity.   Modern biotechnology, through the use of recombinant DNA techniques, has been used for food production for some time now. Therefore, particular attention should be paid to the safety of foods and food additives produced by recombinant DNA techniques. For this reason, Japan set out the “Guideline for Safety Assessment of Foods and Food Additives Produced by Recombinant DNA Techniques” and “Guideline for Manufacturing Foods and Food Additives Produced by Recombinant DNA Techniques,” in 1991.

  3. DOE technical standards list. Department of Energy standards index

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-08-01

    This document was prepared for use by personnel involved in the selection and use of DOE technical standards and other Government and non-Government standards. This TSL provides listing of current DOE technical standards, non-Government standards that have been adopted by DOE, other Government documents in which DOE has a recorded interest, and canceled DOE technical standards. Information on new DOE technical standards projects, technical standards released for coordination, recently published DOE technical standards, and activities of non-Government standards bodies that may be of interest to DOE is published monthly in Standards Actions.

  4. Craniospinal radiotherapy in adult medulloblastoma

    Energy Technology Data Exchange (ETDEWEB)

    Selek, U.; Zorlu, F.; Hurmuz, P.; Cengiz, M.; Gurkaynak, M. [Hacettepe Univ., Ankara (Turkey). Dept. of Radiation Oncology; Turker, A. [Hacettepe Univ., Ankara (Turkey). Dept. of Internal Medicine; Soylemezoglu, F. [Hacettepe Univ., Ankara (Turkey). Dept. of Pathology

    2007-05-15

    Purpose: To evaluate the outcome and prognostic factors of adult patients with medulloblastoma. Patients and Methods: 26 adult medulloblastoma patients with a median age of 27 were subjected to craniospinal radiotherapy. A dose of 30.6 Gy with 1.8 Gy/fraction/day was prescribed to M0 patients, while 36 Gy were to be applied in patients with positive cerebrospinal liquor findings. The posterior fossa was boosted to 54 Gy. While 20 patients underwent external-beam radiotherapy alone, only six received sequential adjuvant chemotherapy. Results: Male/female ratio was 1.2. Preradiotherapy Karnofsky performance status was recorded as median 100%. 50% were classified as poor risk (n = 10, subtotal resection; n = 3, M+). The median follow-up time was 46.5 months. The 5-year actuarial survival rates for recurrence-free, distant metastasis-free, disease-free, and overall survival were 82.5%, 90.8%, 73.5%, and 89.7%, respectively. Patient characteristics, treatment factors and tumor characteristics failed to show any significance in univariate analysis. Grade 3 or 4 late morbidities were not observed. Conclusion: Yet, the current standard of care seems to remain craniospinal irradiation after maximal surgical resection of the primary neoplasm without clear indications for adjuvant chemotherapy. (orig.)

  5. The beryllium "double standard" standard.

    Science.gov (United States)

    Egilman, David S; Bagley, Sarah; Biklen, Molly; Golub, Alison Stern; Bohme, Susanna Rankin

    2003-01-01

    Brush Wellman, the world's leading producer and supplier of beryllium products, has systematically hidden cases of beryllium disease that occurred below the threshold limit value (TLV) and lied about the efficacy of the TLV in published papers, lectures, reports to government agencies, and instructional materials prepared for customers and workers. Hypocritically, Brush Wellman instituted a zero exposure standard for corporate executives while workers and customers were told the 2 microgram standard was "safe." Brush intentionally used its workers as "canaries for the plant," and referred to them as such. Internal documents and corporate depositions indicate that these actions were intentional and that the motive was money. Despite knowledge of the inadequacy of the TLV, Brush has successfully used it as a defense against lawsuits brought by injured workers and as a sales device to provide reassurance to customers. Brush's policy has reaped an untold number of victims and resulted in mass distribution of beryllium in consumer products. Such corporate malfeasance is perpetuated by the current market system, which is controlled by an organized oligopoly that creates an incentive for the neglect of worker health and safety in favor of externalizing costs to victimized workers, their families, and society at large. PMID:14758859

  6. Predictive Modeling in Adult Education

    Science.gov (United States)

    Lindner, Charles L.

    2011-01-01

    The current economic crisis, a growing workforce, the increasing lifespan of workers, and demanding, complex jobs have made organizations highly selective in employee recruitment and retention. It is therefore important, to the adult educator, to develop models of learning that better prepare adult learners for the workplace. The purpose of…

  7. State Standards: Authenticity vs. Diversity.

    Science.gov (United States)

    Davidson, Marcia R.; Howell, Kenneth W.

    1997-01-01

    Reviews problems with the current movement to use national standards and performance assessment to reform education and the impact of the standards on students with disabilities. The characteristics of standards, as they are currently being employed, are discussed, along with issues related to measurement, reliability, and validity. (Author/CR)

  8. Testing the standard model

    International Nuclear Information System (INIS)

    Ways in which various facilities may be used to test the standard model were discussed. Topics addressed include: intermediate vector bosons, neutral current couplings, Higgs Bosons, toponium, naked quarks, glueballs, mixing angles and heavy ions

  9. Current Situation of Standardization of Engineering Risk Management and Development Trend in China%风险管理标准现状及我国工程风险管理标准化发展趋势

    Institute of Scientific and Technical Information of China (English)

    张辉

    2014-01-01

    The quality and safety risk have been at a more and more high level in engineering construction.The economic development and social stability are affected by the key factor of high frequency accidents now;therefore,in order to realize pre-control and management of quality and safety risk management of engineering construction actively,a normal risk management system should be established.According to the current situa-tion analysis of risk management in engineering construction of Australia & New Zealand,England,Interna-tional Standardization Organization and China,the main contents,structure system,rating criterion,applica-tion scope,key points and the difference among the different standards are discussed.The analysis and discus-sion results will provide some guide and reference to establish the system and consummate the technical stand-ards for risk management standardization of the engineering construction in China to some extent.Moreover, the development trend of risk management standardization in engineering construction field is discussed;and some suggestion on the development trend and main tasks of risk management standardization are proposed.%随着我国城镇化发展的进一步推进,工程建设质量安全风险越来越高,工程风险事件频发已经成为制约我国经济建设可持续发展和社会稳定的关键因素,因此,有必要通过系统化、标准化、规范化的风险管理标准体系,实现“主动控制、主动管理”建设工程的施工质量安全风险。本文通过对澳大利亚/新西兰、英国、国际标准化组织以及我国的工程相关风险管理标准现状分析,探讨了各国风险管理标准的主要内容、结构体系、等级标准、适用范围、主要特点及不同之处,为我国工程建设风险管理标准体系的构建、相关技术标准的完善提供一定的借鉴和参考。同时,本文探讨了我国工程建设领域的风险管理标准化发展趋势

  10. Adult medulloblastoma.

    OpenAIRE

    Pobereskin, L; Treip, C

    1986-01-01

    Twelve cases of adult onset medulloblastoma are presented. Clinical features, treatment and outcome are discussed. It was found that the survival rates for adults are no better than for children. There were no clinical or histological features that distinguished these tumours from those occurring in childhood, except for a higher incidence of hemisphere lesions.

  11. Standards for reactor accident cases

    International Nuclear Information System (INIS)

    The Committee on Standards for reactor accident cases in the Netherlands published its recommendations to the Minister of Health. Maximum permissible quantities of radiation and radionuclide intake are presented for adults and children as well as pregnant women. Exposure limit standards for the whole body as well as specific organs and other parts are given. Also considered is the contamination of cattle and cows' milk. The standards are compared with those of the ICRP and the English Medical Research Council

  12. Photometric Standards for Non-Standard Filters

    Science.gov (United States)

    Hoot, John E.

    2015-05-01

    The AAVSO, professional collaborators, and research consortiums are increasingly requesting that photometric observations be submitted after they have been transformed onto 'standard' photometric systems. This greatly reduces the burden on the principal investigators in managing and merging data from many disparate contributors, but discourages many potential contributors who are unaware that their present equipment can make a valuable contribution. Many potential observers, amateurs, students and instructors are confused over what filters are required and what standards are best. This paper focuses on the best standards and observation methods for observers with one shot color cameras and those possessing monochrome CCD cameras with LRGB filter sets, the two most common configurations used in amateur and educational observatories. This paper examines which current standards best match common equipment and present effective ways for amateurs and students to reduce data to standard systems with common tools and a minimum of mathematical rigor.

  13. The Sonoma Water Evaluation Trial (SWET): A randomized drinking water intervention trial to reduce gastrointestinal illness in older adults

    Science.gov (United States)

    Objectives. We estimate the risk of highly credible gastrointestinal illness (HCGI) among adults 55 and older in a community drinking tap water meeting current U.S. standards. Methods. We conducted a randomized, triple-blinded, crossover trial in 714 households (988 indiv...

  14. Intra-rater reproducibility and validity of Nintendo Wii Balance Tests in community-dwelling Older Adults

    DEFF Research Database (Denmark)

    Jørgensen, Martin; Læssøe, Uffe; Hendriksen, C;

    2014-01-01

    The aims of the current study were to examine the intrarater intersession reproducibility of the Nintendo Wii agility and stillness tests and explore the concurrent validity in relation to gold-standard force-plate analysis. Within-day intersession reproducibility was examined in 30 older adults...

  15. DOE technical standards list: Department of Energy standards index

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1997-06-01

    This technical standards list (TSL) was prepared for use by personnel involved in the selection and use of US DOE technical standards and other government and non-government standards. This TSL provides listings of current DOE technical standards, non-government standards that have been adopted by DOE, other government documents in which DOE has a recorded interest, and cancelled DOE technical standards. Standards are indexed by type in the appendices to this document. Definitions of and general guidance for the use of standards are also provided.

  16. Decommissioning standards

    International Nuclear Information System (INIS)

    EPA has agreed to establish a series of environmental standards for the safe disposal of radioactive waste through participation in the Interagency Review Group on Nuclear Waste Management (IRG). One of the standards required under the IRG is the standard for decommissioning of radioactive contaminated sites, facilities, and materials. This standard is to be proposed by December 1980 and promulgated by December 1981. Several considerations are important in establishing these standards. This study includes discussions of some of these considerations and attempts to evaluate their relative importance. Items covered include: the form of the standards, timing for decommissioning, occupational radiation protection, costs and financial provisions. 4 refs

  17. Adult growth hormone deficiency

    OpenAIRE

    Vishal Gupta

    2011-01-01

    Adult growth hormone deficiency (AGHD) is being recognized increasingly and has been thought to be associated with premature mortality. Pituitary tumors are the commonest cause for AGHD. Growth hormone deficiency (GHD) has been associated with neuropsychiatric-cognitive, cardiovascular, neuromuscular, metabolic, and skeletal abnormalities. Most of these can be reversed with growth hormone therapy. The insulin tolerance test still remains the gold standard dynamic test to diagnose AGHD. Growth...

  18. Tuberculosis in Older Adults.

    Science.gov (United States)

    Rajagopalan, Shobita

    2016-08-01

    Tuberculosis (TB) remains one of the world's most lethal infectious diseases. Preventive and control strategies among other high-risk groups, such as the elderly population, continues to be a challenge. Clinical features of TB in older adults may be atypical and confused with age-related diseases. Diagnosis and management of TB in the elderly person can be difficult; treatment can be associated with adverse drug reactions. This article reviews the current global epidemiology, pathogenesis, clinical characteristics, diagnosis, management, and prevention of Mycobacterium tuberculosis infection in community-dwelling and institutionalized aging adults. PMID:27394018

  19. Adult teachers

    DEFF Research Database (Denmark)

    Larsen, Lea Lund

    2011-01-01

    In this paper I examine the research into the process of adult teachers’ practice-based learning as a part of an on-going project titled “Competence development through practice-based learning – a study of adult teacher’s learning processes”. The project relies on the notion of the adult teacher as...... a 'reflective practitioner’, who develops 'the language of practice’, through experience and learns when she is exposed to 'disjuncture’. Research done on continuing professional development and the inquiries done in the field of teacher thinking and within this the research on novices becoming...

  20. Current Situation and Analysis of Body Composition of Adults in Shanghai,2010%2010年上海市成年人身体成分现状与分析

    Institute of Scientific and Technical Information of China (English)

    陈千红; 王人卫

    2014-01-01

    目的:分析上海市成年人身体成分的现状并提出改善对策。方法:基于2010年国民体质监测的上海市18个区县2059岁成年人,共29322名,其中男性14562名,女性14760名。选取反应身体成分的测试指标及其派生指标。采用独立样本t检验,分析各指标不同年龄段及性别间的差异;选取问卷调查数据中的部分指标(如年龄段、性别、职业、受教育程度、所在单位是否有体育锻炼补贴等),采用二元logistic回归,分析除体力活动和饮食行为以外影响肥胖的因素。结果:上海市成年人身体成分多数指标随年龄增长而增长。超重和肥胖检出率分别为30�3%、8�5%,其中男性分别为38�2%、11�0%,女性分别为22�5%、6�1%;中心性肥胖率为42�7%,其中男性为49�9%,女性为35�7%;超重率与2005年相比降低了0�5个百分点,肥胖率增长了1�4个百分点。年龄段、性别、受教育程度、职业、所在工作场所是否有公共体育场地设施、居住地点离工作场所的距离、是否经常熬夜和日睡眠时间可能是肥胖的影响因素。结论:上海市成年人超重和肥胖率较高,且肥胖率十年间呈现持续增长趋势。肥胖是多因素导致的疾病,肥胖的防治工作应采取有效的综合性措施。%Purpose:To analyze the current body composi-tion of adults in Shanghai and propose improvement meas-ures. Method:Based on the data set of 2010 National Phy-sique Monitoring in Shanghai, including 18 districts or counties,of which 29322 adults aged 20 59(14562 men and 14760 women ) were chosen. Then indicators about body composition and their derived indicators were ana-lyzed using independent sample t-test for their age and gender differences;in addition to physical inactivity and unhealthy diet,the possible contributing factors of obesity in the survey data(age,sex,occupation,education level, the

  1. The Questions Of Current Institutions Accounting Standards and the Improved Measures%现行事业单位会计准则存在的问题及改进措施

    Institute of Scientific and Technical Information of China (English)

    王嘉军

    2009-01-01

    As continuous development of market economy, the business of Chinese various economic organizations has undergone great changes, thus requirements to accounting have changed. The defects of current Institutions accountancy standard is a main reason of reformation to institutions accountancy. There are some significances to the improvement of institution accouting work and promotion of the de-velopment to institution accouting field.%随着市场经济的不断发展,我国各经济组织的业务发生了很大的变化,对会计活动提出新的要求.现行事业单位会计准则制度本身存在的缺陷是事业单位会计改革的主要原因.改进事业单位的会计工作,对促进事业单位会计工作的发展具有一定的意义.

  2. IMEF eddy current test

    International Nuclear Information System (INIS)

    The eddy current inspection technique which can detects in irradiated fuel rod cladding is described. Theoretical considerations for eddy current experiments devices, and experimental procedures are described. By doing the experiments on standard sample, conditions for defect test are established. (author). 1 tab., 9 figs., 5 refs

  3. Standard NIM instrumentation system

    International Nuclear Information System (INIS)

    NIM is a standard modular instrumentation system that is in wide use throughout the world. As the NIM system developed and accommodations were made to a dynamic instrumentation field and a rapidly advancing technology, additions, revisions and clarifications were made. These were incorporated into the standard in the form of addenda and errata. This standard is a revision of the NIM document, AEC Report TID-20893 (Rev. 4) dated July 1974. It includes all the addenda and errata items that were previously issued as well as numerous additional items to make the standard current with modern technology and manufacturing practice

  4. Standard NIM instrumentation system

    Energy Technology Data Exchange (ETDEWEB)

    1990-05-01

    NIM is a standard modular instrumentation system that is in wide use throughout the world. As the NIM system developed and accommodations were made to a dynamic instrumentation field and a rapidly advancing technology, additions, revisions and clarifications were made. These were incorporated into the standard in the form of addenda and errata. This standard is a revision of the NIM document, AEC Report TID-20893 (Rev. 4) dated July 1974. It includes all the addenda and errata items that were previously issued as well as numerous additional items to make the standard current with modern technology and manufacturing practice.

  5. Standard NIM instrumentation system

    CERN Document Server

    1990-01-01

    NIM is a standard modular instrumentation system that is in wide use throughout the world. As the NIM system developed and accommodations were made to a dynamic instrumentation field and a rapidly advancing technology, additions, revisions and clarifications were made. These were incorporated into the standard in the form of addenda and errata. This standard is a revision of the NIM document, AEC Report TID- 20893 (Rev 4) dated July 1974. It includes all the addenda and errata items that were previously issued as well as numerous additional items to make the standard current with modern technology and manufacturing practice.

  6. Adult Strabismus

    Science.gov (United States)

    ... will likely improve the double vision and depth perception. Also, strabismus affects adults in emotional, social, and ... muscle surgery is usually not severe. Headache, pulling sensation with eye movement and foreign body sensation in ...

  7. Accounting standards

    NARCIS (Netherlands)

    B. Stellinga

    2014-01-01

    The European and global regulation of accounting standards have witnessed remarkable changes over the past twenty years. In the early 1990s, EU accounting practices were fragmented along national lines and US accounting standards were the de facto global standards. Since 2005, all EU listed companie

  8. International Standards.

    Science.gov (United States)

    Havard-Williams, Peter

    1982-01-01

    Discussion of standardization on an international scale for resource sharing--cooperation, coordination, interlibrary loans, cooperative acquisition and cataloging--focuses on a definition of standards; the development of standards for cataloging; public, school, and university libraries; and library education. A 60-item bibliography is included.…

  9. Survey on current status of laboratory test method and experimental consideration for establishing standardized procedure of material containing bentonite. Report of collaboration research between JAEA and CRIEPI (Joint research)

    International Nuclear Information System (INIS)

    In the current concept of repository for radioactive waste disposal, compacted bentonite as well as bentonite based material will be used as an engineered barrier mainly for inhibiting migration of radioactive nuclides. In most cases, properties of bentonite, such as low permeability etc., are obtained by laboratory tests. However, results of laboratory tests of bentonite often vary considerably even if index parameter, such as effective clay density, is constant. One of the causes of the variability is considered to be lack of standardized method of laboratory test for bentonite. Thus standardization of laboratory test methods for bentonite is needed. So, investigation for establishing standardized laboratory test method of bentonite is conducted based on the results of survey on current status of laboratory test method for bentonite. In particular, the literature survey as well as laboratory tests were conducted to find factors affecting the results of laboratory tests for bentonite and to estimate their degree of influence. The following conclusions are obtained through this study. (1) Hydraulic conductivity test. According to the results of literature survey, it is revealed that constant pressure permeability test and consolidation test are currently used for measuring hydraulic conductivity of bentonite and that (a) hydraulic gradient, (b) local seepage flow between lateral surface of the specimen and lateral wall of the container, (c) water pressure which is applied to the specimen, (d) degree of saturation and (e) size of the specimen possibly affect the results of the constant pressure permeability test, while (f) friction between lateral surface of the specimen and lateral wall of the container accompanied by deformation of the specimen, (g) consolidation pressure together with factors (d), (e) affect the results of the consolidation test. Literature which describes that factors (a), (b) and (e) affect the results of the constant pressure permeability test

  10. Qualidade do ar em ambientes internos hospitalares: estudo de caso e análise crítica dos padrões atuais Indoor air quality in hospitals: a case study and a critical review of current standards

    Directory of Open Access Journals (Sweden)

    Marina Eller Quadros

    2009-09-01

    Full Text Available O objetivo deste trabalho foi avaliar a qualidade do ar em três categorias de ambientes hospitalares: unidade de terapia intensiva (UTI adulto, UTI neonatal (UTN e centro cirúrgico de um hospital em Florianópolis, Brasil. Avaliaram-se a concentração de dióxido de carbono, a vazão e renovação de ar nas salas do centro cirúrgico. A concentração de bioaerossóis foi estimada em um dia de avaliação para cada ambiente. Não se observou relação entre a concentração de bioaerossóis e o tempo de uso das salas de cirurgia. A concentração média de bioaerossóis foi de 231 UFC.m-3 para fungos e de 187 UFC.m-3 para bactérias. Os ambientes avaliados atendiam aos valores recomendados pela legislação vigente. Os resultados permitiram avaliar criticamente essa legislação e apresentar sugestões para estabelecimento de uma resolução específica para ambientes hospitalares no Brasil.The objective of this paper was to evaluate the air quality in three indoor hospital environments: a neonatal intensive care unit (ICU, an adult ICU and a surgical ward of a hospital in Florianópolis, Brazil. Carbon dioxide concentrations, exchange air flow rates as well as fungi and bacteria concentrations were measured in these rooms. Bioaerosol concentrations were evaluated throughout one-work day for each operating room. No relationship was observed between bioaerosol concentration and the period of use in the surgical ward. Average bioaerosol concentrations were of 231 UFC.m-3 for filamentous fungi and 187 UFC.m-3 for bacteria. All environments evaluated were, overall, in compliance with current legislations. Results allowed a critical review of the present regulations and suggestions for the establishment of a specific regulation for hospital environments in Brazil.

  11. Quality measurement of semantic standards

    OpenAIRE

    Folmer, E.J.A.; Oude Luttighuis, P.H.W.M.; Hillegersberg, van, R.

    2010-01-01

    Quality of semantic standards is unadressed in current research while there is an explicit need from standard developers. The business importance is evident since quality of standards will have impact on its diffusion and achieved interoperability in practice. An instrument to measure the quality of semantic standards is designed to contribute to the knowledge domain, standards developers and might ultimo lead to improved interoperability. This instrument is iteratively designed with multiple...

  12. Transition experiences and health care utilization among young adults with type 1 diabetes

    Directory of Open Access Journals (Sweden)

    Garvey KC

    2013-08-01

    -thirds (66% reported receiving all recommended diabetes screening tests in the previous year, with no difference according to provider type. Conclusion: In this sample, transition preparation was variable and one quarter reported gaps in obtaining adult diabetes care. Nevertheless, the majority endorsed currently receiving regular diabetes care, although visit frequency differed by provider type. Because locating patients after transition was incomplete, our findings suggest the need for standardized methods to track transitioning patients. Keywords: type 1 diabetes mellitus, health care delivery, young adults, transition to adult care

  13. Standardization of depression measurement

    DEFF Research Database (Denmark)

    Wahl, Inka; Löwe, Bernd; Bjørner, Jakob;

    2014-01-01

    OBJECTIVES: To provide a standardized metric for the assessment of depression severity to enable comparability among results of established depression measures. STUDY DESIGN AND SETTING: A common metric for 11 depression questionnaires was developed applying item response theory (IRT) methods. Data...... of 33,844 adults were used for secondary analysis including routine assessments of 23,817 in- and outpatients with mental and/or medical conditions (46% with depressive disorders) and a general population sample of 10,027 randomly selected participants from three representative German household...... surveys. RESULTS: A standardized metric for depression severity was defined by 143 items, and scores were normed to a general population mean of 50 (standard deviation = 10) for easy interpretability. It covers the entire range of depression severity assessed by established instruments. The metric allows...

  14. Communications standards

    CERN Document Server

    Stokes, A V

    1986-01-01

    Communications Standards deals with the standardization of computer communication networks. This book examines the types of local area networks (LANs) that have been developed and looks at some of the relevant protocols in more detail. The work of Project 802 is briefly discussed, along with a protocol which has developed from one of the LAN standards and is now a de facto standard in one particular area, namely the Manufacturing Automation Protocol (MAP). Factors that affect the usage of networks, such as network management and security, are also considered. This book is divided into three se

  15. Pathways of Knowing: Integrating Citizen Science and Critical Thinking in the Adult ELL Classroom

    Science.gov (United States)

    Basham, Melody

    This action research study examines what common perceptions and constructs currently exist in educating adult immigrants in Arizona and considers how might the integration of citizen science with the current English curriculum promote higher order thinking and educational equity in this population. A citizen science project called the Mastodon Matrix Project was introduced to a Level 2 ELAA (English Language Acquisition for Adults) classroom and aligned with the Arizona Adult Standards for ELAA education. Pre and post attitudinal surveys, level tests, and personal meaning maps were implemented to assess student attitudes towards science, views on technology, English skills, and knowledge gained as a result of doing citizen science over a period of 8 weeks.

  16. Human Metapneumovirus in Adults

    OpenAIRE

    Haas, Lenneke E. M.; Steven F. T. Thijsen; Leontine van Elden; Heemstra, Karen A.

    2013-01-01

    Human metapneumovirus (HMPV) is a relative newly described virus. It was first isolated in 2001 and currently appears to be one of the most significant and common human viral infections. Retrospective serologic studies demonstrated the presence of HMPV antibodies in humans more than 50 years earlier. Although the virus was primarily known as causative agent of respiratory tract infections in children, HMPV is an important cause of respiratory infections in adults as well. Almost all children ...

  17. Achieving Standardization

    DEFF Research Database (Denmark)

    Henningsson, Stefan

    2016-01-01

    International e-Customs is going through a standardization process. Driven by the need to increase control in the trade process to address security challenges stemming from threats of terrorists, diseases, and counterfeit products, and to lower the administrative burdens on traders to stay...... competitive, national customs and regional economic organizations are seeking to establish a standardized solution for digital reporting of customs data. However, standardization has proven hard to achieve in the socio-technical e-Customs solution. In this chapter, the authors identify and describe what has...... to be harmonized in order for a global company to perceive e-Customs as standardized. In doing so, they contribute an explanation of the challenges associated with using a standardization mechanism for harmonizing socio-technical information systems....

  18. Achieving Standardization

    DEFF Research Database (Denmark)

    Henningsson, Stefan

    2014-01-01

    International e-Customs is going through a standardization process. Driven by the need to increase control in the trade process to address security challenges stemming from threats of terrorists, diseases, and counterfeit products, and to lower the administrative burdens on traders to stay...... competitive, national customs and regional economic organizations are seeking to establish a standardized solution for digital reporting of customs data. However, standardization has proven hard to achieve in the socio-technical e-Customs solution. In this chapter, the authors identify and describe what has...... to be harmonized in order for a global company to perceive e-Customs as standardized. In doing so, they contribute an explanation of the challenges associated with using a standardization mechanism for harmonizing socio-technical information systems....

  19. Quality measurement of semantic standards

    NARCIS (Netherlands)

    Folmer, E.J.A.; Oude Luttighuis, P.H.W.M.; Hillegersberg, J. van

    2010-01-01

    Quality of semantic standards is unadressed in current research while there is an explicit need from standard developers. The business importance is evident since quality of standards will have impact on its diffusion and achieved interoperability in practice. An instrument to measure the quality of

  20. ISO radiation sterilization standards

    International Nuclear Information System (INIS)

    This presentation provides an overview of the current status of the ISO radiation sterilization standards. The ISO standards are voluntary standards which detail both the validation and routine control of the sterilization process. ISO 11137 was approved in 1994 and published in 1995. When reviewing the standard you will note that less than 20% of the standard is devoted to requirements and the remainder is guidance on how to comply with the requirements. Future standards developments in radiation sterilization are being focused on providing additional guidance. The guidance that is currently provided in informative annexes of ISO 11137 includes: device/packaging materials, dose setting methods, and dosimeters and dose measurement, currently, there are four Technical Reports being developed to provide additional guidance: 1. AAMI Draft TIR, 'Radiation Sterilization Material Qualification' 2. ISO TR 13409-1996, 'Sterilization of health care products - Radiation sterilization - Substantiation of 25 kGy as a sterilization dose for small or infrequent production batches' 3. ISO Draft TR, 'Sterilization of health care products - Radiation sterilization Selection of a sterilization dose for a single production batch' 4. ISO Draft TR, 'Sterilization of health care products - Radiation sterilization-Product Families, Plans for Sampling and Frequency of Dose Audits'

  1. Charged current review

    International Nuclear Information System (INIS)

    Experimental measurements of the τ lifetime and leptonic branching ratios are combined to give updated world averages for these quantities. The results are then used to test the universality of the electroweak charged current couplings to the three lepton species and are found to be consistent with Standard Model predictions at the level of 0.2%, permitting limits to be derived on non-Standard Model physics such as the mass of the τ neutrino

  2. CPR: Adult

    Medline Plus

    Full Text Available Refresher Center Home FIRST AID, CPR and AED LIFEGUARDING Refresher Putting It All Together: CPR—Adult (2:03) Refresher videos only utilize this player QUICK LINKS Home RedCross.org Purchase Course Materials Shop Our Store ...

  3. Spin current

    CERN Document Server

    Valenzuela, Sergio O; Saitoh, Eiji; Kimura, Takashi

    2012-01-01

    In a new branch of physics and technology called spin-electronics or spintronics, the flow of electrical charge (usual current) as well as the flow of electron spin, the so-called 'spin current', are manipulated and controlled together. This book provides an introduction and guide to the new physics and application of spin current.

  4. zebraflash transgenic lines for in vivo bioluminescence imaging of stem cells and regeneration in adult zebrafish

    OpenAIRE

    Chen, Chen-Hui; Durand, Ellen; Wang, Jinhu; Zon, Leonard I.; Poss, Kenneth D.

    2013-01-01

    The zebrafish has become a standard model system for stem cell and tissue regeneration research, based on powerful genetics, high tissue regenerative capacity and low maintenance costs. Yet, these studies can be challenged by current limitations of tissue visualization techniques in adult animals. Here we describe new imaging methodology and present several ubiquitous and tissue-specific luciferase-based transgenic lines, which we have termed zebraflash, that facilitate the assessment of rege...

  5. EOS standards

    Energy Technology Data Exchange (ETDEWEB)

    Greeff, Carl W [Los Alamos National Laboratory

    2011-01-12

    An approach to creating accurate EOS for pressure standards is described. Applications to Cu, Au, and Ta are shown. Extension of the method to high compressions using DFT is illustrated. Comparisons with modern functionals show promise.

  6. Pilomyxoid astrocytoma in an adult woman: Case report.

    Science.gov (United States)

    Kibola, Adam H; McClelland, Shearwood; Hlavin, Joseph; Friedman, Jonathan A

    2015-01-01

    Pilomyxoid astrocytoma (PMA) is a recently classified WHO grade II astrocytoma that is histologically similar to pilocytic astrocytoma (PA). Both tumors typically present in childhood, but PMA is more aggressive with higher rates of recurrence and cerebrospinal fluid dissemination. Currently, there is no standardized treatment protocol for PMA although this will change with increased awareness of this disease entity within the neurosurgical community. We present a 22-year-old patient with a left frontal lobe PMA manifesting with atypical radiographic findings. This is the first reported case of PMA in an adult woman. PMID:26458706

  7. Pilomyxoid astrocytoma in an adult woman: Case report

    Directory of Open Access Journals (Sweden)

    Adam H Kibola

    2015-01-01

    Full Text Available Pilomyxoid astrocytoma (PMA is a recently classified WHO grade II astrocytoma that is histologically similar to pilocytic astrocytoma (PA. Both tumors typically present in childhood, but PMA is more aggressive with higher rates of recurrence and cerebrospinal fluid dissemination. Currently, there is no standardized treatment protocol for PMA although this will change with increased awareness of this disease entity within the neurosurgical community. We present a 22-year-old patient with a left frontal lobe PMA manifesting with atypical radiographic findings. This is the first reported case of PMA in an adult woman.

  8. [Adult twins].

    Science.gov (United States)

    Charlemaine, Christiane

    2006-12-31

    This paper explores the deep roots of closeness that twins share in their youngest age and their effect on their destiny at the adult age. Psychologists believe the bond between twins begins in utero and develops throughout the twins' lives. The four patterns of twinship described show that the twin bond is determined by the quality of parenting that twins receive in their infancy and early childhood. Common problems of adult twins bring about difficulties to adapt in a non-twin world. The nature versus nurture controversy has taken on new life focusing on inter-twin differences and the importance of parent-child interaction as fundamental to the growth and development of personality. PMID:17352324

  9. Major Depression Among Adults

    Science.gov (United States)

    ... Children Autism Spectrum Disorder (ASD) Eating Disorders Among Adults - Anorexia Nervosa Eating Disorders Among Adults - Binge Eating Disorder Eating ... Children Autism Spectrum Disorder (ASD) Eating Disorders Among Adults - Anorexia Nervosa Eating Disorders Among Adults - Binge Eating Disorder Eating ...

  10. Panic Disorder among Adults

    Science.gov (United States)

    ... Children Autism Spectrum Disorder (ASD) Eating Disorders Among Adults - Anorexia Nervosa Eating Disorders Among Adults - Binge Eating Disorder Eating ... Children Autism Spectrum Disorder (ASD) Eating Disorders Among Adults - Anorexia Nervosa Eating Disorders Among Adults - Binge Eating Disorder Eating ...

  11. Bipolar Disorder Among Adults

    Science.gov (United States)

    ... Children Autism Spectrum Disorder (ASD) Eating Disorders Among Adults - Anorexia Nervosa Eating Disorders Among Adults - Binge Eating Disorder Eating ... Children Autism Spectrum Disorder (ASD) Eating Disorders Among Adults - Anorexia Nervosa Eating Disorders Among Adults - Binge Eating Disorder Eating ...

  12. Obstructive sleep apnea - adults

    Science.gov (United States)

    Sleep apnea - obstructive - adults; Apnea - obstructive sleep apnea syndrome - adults; Sleep-disordered breathing - adults; OSA - adults ... When you sleep, all of the muscles in your body become more relaxed. This includes the muscles that help keep your ...

  13. Measuring sleep quality in older adults: a comparison using subjective and objective methods.

    Directory of Open Access Journals (Sweden)

    Glenn J Landry

    2015-09-01

    Full Text Available Sleep quality decreases with aging and thus sleep complaints are prevalent in older adults, particularly for those with cognitive impairment and dementia. For older adults, emerging evidence suggests poor sleep quality increases risk of developing cognitive impairment and dementia. Given the aging population – and the impending economic burden associated with increasing numbers of dementia patients – there is pressing need to improve sleep quality among older adults. As such, research efforts have increased focus on investigating the association between age-related sleep changes and cognitive decline in older adults. Sleep quality is a complex construct to evaluate empirically, and yet the Pittsburg Sleep Quality Index (PSQI is commonly used in studies as their only measure of sleep quality. Furthermore, the PSQI may not be the best sleep quality measure for older adults, due to its reliance on the cognitive capacity to reflect on the past month. Further study is needed to determine the PSQI’s validity among older adults. Thus, the current study examined sleep quality for 78 community dwelling adults 55+ to determine the PSQI’s predictive validity for objective sleep quality (as measured by actigraphy. We compared two subjective measures of sleep quality – the PSQI and Consensus Sleep Diary (CSD – with actigraphy (MotionWatch 8; camntech. Our results suggest perceived sleep quality is quite different from objective reality, at least for adults 55+. Importantly, we show this difference is unrelated to age, gender, education, or cognitive status (assessed using standard screens. Previous studies have shown the PSQI to be a valuable tool for assessing subjective sleep quality; however, our findings indicate for older adults the PSQI should not be used as a substitute for actigraphy, or vice versa. Hence, we conclude best practice is to include both subjective and objective measures when examining sleep quality in older adults (i.e., the

  14. Measuring sleep quality in older adults: a comparison using subjective and objective methods.

    Science.gov (United States)

    Landry, Glenn J; Best, John R; Liu-Ambrose, Teresa

    2015-01-01

    Sleep quality decreases with aging and thus sleep complaints are prevalent in older adults, particularly for those with cognitive impairment and dementia. For older adults, emerging evidence suggests poor sleep quality increases risk of developing cognitive impairment and dementia. Given the aging population-and the impending economic burden associated with increasing numbers of dementia patients-there is pressing need to improve sleep quality among older adults. As such, research efforts have increased focus on investigating the association between age-related sleep changes and cognitive decline in older adults. Sleep quality is a complex construct to evaluate empirically, and yet the Pittsburg Sleep Quality Index (PSQI) is commonly used in studies as their only measure of sleep quality. Furthermore, the PSQI may not be the best sleep quality measure for older adults, due to its reliance on the cognitive capacity to reflect on the past month. Further study is needed to determine the PSQI's validity among older adults. Thus, the current study examined sleep quality for 78 community dwelling adults 55+ to determine the PSQI's predictive validity for objective sleep quality (as measured by actigraphy). We compared two subjective measures of sleep quality-the PSQI and Consensus Sleep Diary (CSD)-with actigraphy (MotionWatch 8©; camntech). Our results suggest perceived sleep quality is quite different from objective reality, at least for adults 55+. Importantly, we show this difference is unrelated to age, gender, education, or cognitive status (assessed using standard screens). Previous studies have shown the PSQI to be a valuable tool for assessing subjective sleep quality; however, our findings indicate for older adults the PSQI should not be used as a substitute for actigraphy, or vice versa. Hence, we conclude best practice is to include both subjective and objective measures when examining sleep quality in older adults (i.e., the PSQI, CSD, and actigraphy). PMID

  15. Adult Immunization

    OpenAIRE

    Omer Coskun

    2008-01-01

    Despite the many advances in modern medicine, each year thousands of people in the world die from diseases that are easily prevented by safe and effective vaccines. Few measures in preventive medicine are of such proven value and as easy to implement as routine immunization against infectious diseases. Prevention of infection by immunization is a lifelong process. There are a number of vaccines that all adults (¡I18 years) require. There are also other vaccines that need to be tailored t...

  16. Adult Leukemias

    OpenAIRE

    Moore, Lyall K.

    1984-01-01

    Over the past several years, advances have been made in the classification, diagnosis and therapy of the adult leukemias. The overall prognosis and quality of life have improved greatly, especially for patients with acute nonlymphoblastic leukemias. Some of the advances are described in this article. The importance of the clinical, laboratory and diagnostic tests for acute, chronic granulocytic and chronic lymphocytic leukemia are stressed. The therapy and prognosis for patients with the vari...

  17. Alternative pharmacological strategies for adult ADHD treatment: a systematic review.

    Science.gov (United States)

    Buoli, Massimiliano; Serati, Marta; Cahn, Wiepke

    2016-01-01

    Adult Attention Deficit Hyperactivity Disorder (ADHD) is a prevalent psychiatric condition associated with high disability and frequent comorbidity. Current standard pharmacotherapy (methylphenidate and atomoxetine) improves ADHD symptoms in the short-term, but poor data were published about long-term treatment. In addition a number of patients present partial or no response to methylphenidate and atomoxetine. Research into the main database sources has been conducted to obtain an overview of alternative pharmacological approaches in adult ADHD patients. Among alternative compounds, amphetamines (mixed amphetamine salts and lisdexamfetamine) have the most robust evidence of efficacy, but they may be associated with serious side effects (e.g. psychotic symptoms or hypertension). Antidepressants, particularly those acting as noradrenaline or dopamine enhancers, have evidence of efficacy, but they should be avoided in patients with comorbid bipolar disorder. Finally metadoxine and lithium may be particularly suitable in case of comorbid alcohol misuse or bipolar disorder. PMID:26693882

  18. Environmental radiation standards and risk limitation

    International Nuclear Information System (INIS)

    The Environmental Protection Agency and Nuclear Regulatory Commission have established environmental radiation standards for specific practices which correspond to limits on risk to the public that vary by several orders of magnitude and often are much less than radiation risks that are essentially unregulated, e.g., risks from radon in homes. This paper discusses a proposed framework for environmental radiation standards that would improve the correspondence with limitation of risk. This framework includes the use of limits on annual effective dose equivalent averaged over a lifetime, rather than limits on dose equivalent to whole body or any organ for each year of exposure, and consideration of exposures of younger age groups as well as adults; limits on annual effective dose equivalent averaged over a lifetime no lower than 0.25 mSv (25 mrem) per practice; maintenance of all exposures as low as reasonably achievable (ALARA); and establishment of a generally applicable de minimis dose for public exposures. Implications of the proposed regulatory framework for the current system of standards for limiting public exposures are discussed. 20 refs

  19. Globalization of HVDC Standards

    Institute of Scientific and Technical Information of China (English)

    Gu Chen

    2011-01-01

    China has made outstanding achievements in the fields of Ultra-High Voltage Direct Current (UHV DC) power transmission and security of large-scale power grid till now,and the smart grid construction has been under way,all of which put forward much higher strategic requirements of standards globalization.

  20. Automated Standard Hazard Tool

    Science.gov (United States)

    Stebler, Shane

    2014-01-01

    The current system used to generate standard hazard reports is considered cumbersome and iterative. This study defines a structure for this system's process in a clear, algorithmic way so that standard hazard reports and basic hazard analysis may be completed using a centralized, web-based computer application. To accomplish this task, a test server is used to host a prototype of the tool during development. The prototype is configured to easily integrate into NASA's current server systems with minimal alteration. Additionally, the tool is easily updated and provides NASA with a system that may grow to accommodate future requirements and possibly, different applications. Results of this project's success are outlined in positive, subjective reviews complete by payload providers and NASA Safety and Mission Assurance personnel. Ideally, this prototype will increase interest in the concept of standard hazard automation and lead to the full-scale production of a user-ready application.

  1. Fasteners 5 basic standards

    CERN Document Server

    2011-01-01

    This 3rd edition of DIN Handbook 193 contains 38 fundamental standards on fasteners, covering such areas as countersinks and counterbores, widths across flats, thread run-outs and thread undercuts, bolt and screw ends, stud ends and tapped holes for compression couplings, driving features, tolerances for screw threads and nomenclature. New to this compilation are DIN 34824 dealing with 12 point sockets for bolts and screws and DIN EN ISO 15065 which reflects current practice in Europe with regard to countersinks for countersunk head screws. Also included for the first time is DIN EN ISO 225 "Fasteners - Bolts, screws, studs and nuts - Symbols and descriptions of dimensions" which, together with DIN ISO 1891, now also incorporates terminology in Chinese, Japanese and Swedish. Four standards have been revised for this edition, among them DIN 918 Supplement 3 which provides information on the current status of European standardization relating to fasteners. DIN Handbook 193 is one of a series of six handbooks on...

  2. Signal Processing Strategies for Cochlear Implants Using Current Steering

    Directory of Open Access Journals (Sweden)

    Waldo Nogueira

    2009-01-01

    Full Text Available In contemporary cochlear implant systems, the audio signal is decomposed into different frequency bands, each assigned to one electrode. Thus, pitch perception is limited by the number of physical electrodes implanted into the cochlea and by the wide bandwidth assigned to each electrode. The Harmony HiResolution bionic ear (Advanced Bionics LLC, Valencia, CA, USA has the capability of creating virtual spectral channels through simultaneous delivery of current to pairs of adjacent electrodes. By steering the locus of stimulation to sites between the electrodes, additional pitch percepts can be generated. Two new sound processing strategies based on current steering have been designed, SpecRes and SineEx. In a chronic trial, speech intelligibility, pitch perception, and subjective appreciation of sound were compared between the two current steering strategies and standard HiRes strategy in 9 adult Harmony users. There was considerable variability in benefit, and the mean results show similar performance with all three strategies.

  3. Status of conversion of NE standards to national consensus standards

    International Nuclear Information System (INIS)

    One major goal of the Nuclear Standards Program is to convert existing NE standards into national consensus standards (where possible). This means that an NE standard in the same subject area using the national consensus process. This report is a summary of the activities that have evolved to effect conversion of NE standards to national consensus standards, and the status of current conversion activities. In some cases, all requirements in an NE standard will not be incorporated into the published national consensus standard because these requirements may be considered too restrictive or too specific for broader application by the nuclear industry. If these requirements are considered necessary for nuclear reactor program applications, the program standard will be revised and issued as a supplement to the national consensus standard. The supplemental program standard will contain only those necessary requirements not reflected by the national consensus standard. Therefore, while complete conversion of program standards may not always be realized, the standards policy has been fully supported in attempting to make maximum use of the national consensus standard. 1 tab

  4. Report on the 1st research co-ordination meeting of the co-ordinated research project on standardized high current solid targets for cyclotron production of diagnostic and therapeutic radionuclides

    International Nuclear Information System (INIS)

    of deposition of the oxide on the metal target plate, 2) the stability of the oxide layer during storage and irradiation, 3) the thermal characteristics of the oxide layer especially during irradiation, 4) methods of radioiodine recovery such as dry distillation, and 5) reprocessing of the targets. For the electrodeposited tellurium targets, the improvement of the existing deposition method and the presently used recovery process (wet chemistry) will be done. (ii) to prepare a target for the production of Thallium-201 which will withstand high beam currents in the range of 100 μA or more This will be accomplished through the transfer of the technology available on the electrodeposition of Thallium onto copper plates to produce a smooth, stable surface. The techniques will include the preparation of the targets before irradiation, extraction of the desired radioisotope, and the processing and recovery of the enriched materials after irradiation. Furthermore, a standard procedure for the preparation of trivalent Tl-201 (201Tl+) suitable for polypeptide labelling can be developed. (iii) to prepare a target for the production of Pd-103 from Rhodium. This will be accomplished by transferring the existing technology for the electrodeposition of Rh onto metal plates. The chemical removal of Rh will also be investigated as an integral goal of the CRP. Attempts will be made to investigate the production and quality control methods for the preparation of sealed sources for the treatment of prostate cancer

  5. Measurement system of high voltage and high current measurements at INMETRO - Brazilian Institute for Metrology, Standardization and Industrial Quality; Sistema de medicao de alta tensao e alta corrente do INMETRO - Brasil

    Energy Technology Data Exchange (ETDEWEB)

    Vitorio, Patricia Cals de O.; Franca, Ademir Martins de; Soares, Marco Aurelio; Pereira, Luiz Napoleao; Costa, Danielli Guimaraes; Moreira, Giselle Cobica; Nascimento, Paulo Roberto Mesquita [Instituto Nacional de Metrologia, Normalizacao e Qualidade Industrial (DIMCI/INMETRO), Duque de Caxias, RJ (Brazil). Diretoria de Metrologia Cientifica e Industrial], E-mail: latra@inmetro.gov.br

    2009-07-01

    This work presents the basic characteristics and uncertainties of the calibration equipment in high voltage and high current available at the INMETRO: system of measurement in alternating high voltage up to 200 kV, system of measurement in alternating current up to 2 k A, and system of measurement in continuous high voltage up to 150 kV.

  6. Qualification paths of adult educators in Sweden and Denmark

    OpenAIRE

    Andersson, Per; Köpsén, Susanne; Larson, Anne; Milana, Marcella

    2013-01-01

    The qualification of adult educators is a central aspect of the quality of adult education. However, within current policy discourses and adult education research on the professional development of prospective adult educators, little attention is paid to teacher qualification when compared to other fields of education and training. In this study, we analyse the qualification paths, or learning trajectories, of prospective adult educators in Sweden and Denmark. The analysis is based on narrati...

  7. Dosimetry standards

    International Nuclear Information System (INIS)

    The following leaflets are contained in this folder concerning the National Physical Laboratory's measurement services available in relation to dosimetry standards: Primary standards of X-ray exposure and X-ray irradiation facilities, X-ray dosimetry at therapy levels, Protection-level X-ray calibrations, Therapy-level gamma-ray facility, Fricke dosemeter reference service, Low-dose-rate gamma-ray facility, Penetrameter and kV meter calibration, Measurement services for radiation processing, Dichromate dosemeter reference service, Electron linear accelerator. (U.K.)

  8. Frequency standards

    CERN Document Server

    Riehle, Fritz

    2006-01-01

    Of all measurement units, frequency is the one that may be determined with the highest degree of accuracy. It equally allows precise measurements of other physical and technical quantities, whenever they can be measured in terms of frequency.This volume covers the central methods and techniques relevant for frequency standards developed in physics, electronics, quantum electronics, and statistics. After a review of the basic principles, the book looks at the realisation of commonly used components. It then continues with the description and characterisation of important frequency standards

  9. Current stabilizer

    International Nuclear Information System (INIS)

    A current stabilizer for supplying magnetic lens of β-monochromator at the electron energy up to 1 MeV is described. Stabilization method with use of reference high-stabilized source of direct voltage with switching-in loading (monochromator coil) to circuit of negative feedback of direct-current amplifier with high gain is chosen for stabilization of direct current. The range of current regulation is 0.5 A at available power up to 15 W. Current instability during 10 hour continuous work does not exceed 10-4% that makes it possible to provide instability of electron energy at the monochromator exit using 90Sr+90Y β-nucleide of not more than 10 -4% and number of electrons 2.5x10-4% respectively

  10. Adult hepatoblastoma

    OpenAIRE

    Javier A. Cienfuegos; Tania Labiano; Nicolás Pedano; Gabriel N. Zozaya; Pablo Martí-Cruchaga; Ángel Panizo; Fernando Rotellar

    2013-01-01

    Adult hepatoblastoma (AHB) is a very rare tumor, having been described 45 cases up to June 2012. In contrast to HB in infancy (IHB), it has poor prognosis. We present the case of a 37-year-old asymptomatic woman who consulted for a large -12 cm diameter- mass involving segments 5 and 6 of the liver, and alfa-fetoprotein of 1,556,30 UI/mL. A bisegmentectomy was carried out. The microscopic study confirmed the AHB diagnosis, revealing the presence of epithelial cells forming clusters, trabecula...

  11. Laser standards

    International Nuclear Information System (INIS)

    The history of the development of international, American and British standards for the use of lasers is briefly discussed. Other topics briefly discussed include the biological effects of laser radiation, hazard classification systems for laser systems, maximum permissible exposures and radiation protection measures in practical considerations. (UK)

  12. Differing Perspectives on Older Adult Caregiving.

    Science.gov (United States)

    Brank, Eve M; Wylie, Lindsey E

    2016-07-01

    Informal older adult caregiving allows older adults to stay in their homes or live with loved ones, but decisions surrounding older adult care are fraught with complexities. Related research and case law suggest that an older adult's need for and refusal of help are important considerations; the current study is the first to examine these factors experimentally. Two samples (potential caregivers and care recipients) provided responses regarding anticipated emotions, caregiver abilities, and allocation of daily caregiving decision making based on a vignette portraying an older adult who had a high or low level of autonomy and who accepted or refused help. Study findings suggest differing views about caregiving; potential caregivers may not be as well prepared to take on caregiving as the potential care recipients anticipate and potential caregivers may allocate more decisional responsibility to older adults than the care recipients expect. Implications for older adult abuse are discussed. PMID:24652926

  13. Supporting wellness in adult online education

    OpenAIRE

    Jacklyn J. Thompson; Stella C.S. Porto

    2014-01-01

    Online education cannot continue to grow at the current pace while ignoring a crucial component of campus support, wellness for adult online learners. This paper brings awareness to the concept of wellness as an important student support service in adult online education. It includes a summarized review of relevant literature and identifies specific wellness concerns of adult online learners. The paper also provides examples of how three American higher education institutions are addressing t...

  14. Validity of ultrasonography and measures of adult shoulder function and reliability of ultrasonography in detecting shoulder synovitis in patients with rheumatoid arthritis using magnetic resonance imaging as a gold standard.

    LENUS (Irish Health Repository)

    Bruyn, G A W

    2010-08-01

    To assess the intra- and interobserver reproducibility of musculoskeletal ultrasonography (US) in detecting inflammatory shoulder changes in patients with rheumatoid arthritis, and to determine the agreement between US and the Shoulder Pain and Disability Index (SPADI) and the Disabilities of the Arm, Shoulder, and Hand (DASH) questionnaire, using magnetic resonance imaging (MRI) as a gold standard.

  15. Adult Sinusitis

    Science.gov (United States)

    ... a procedure performed in the physician’s office. No sedation or general anesthesia is needed for the procedure. ... diagnosing sinusitis. In current medical practice, a CT (CAT) scan is the study of choice for imaging ...

  16. Marxism and Adult Education in Britain

    Science.gov (United States)

    Steele, Tom; Taylor, Richard

    2004-01-01

    In British adult education Marxism has been a persistent if marginalised current that has consistently informed its more radical movements and practitioners. This article firstly introduces some contested Marxist perspectives on adult education, particularly around the issues of ideology and incorporation into bourgeois society. Secondly, it…

  17. Supporting Wellness in Adult Online Education

    Science.gov (United States)

    Thompson, Jacklyn J.; Porto, Stella C. S.

    2014-01-01

    Online education cannot continue to grow at the current pace while ignoring a crucial component of campus support, wellness for adult online learners. This paper brings awareness to the concept of wellness as an important student support service in adult online education. It includes a summarized review of relevant literature and identifies…

  18. Fire-resistant materials: European standards and American standards

    International Nuclear Information System (INIS)

    The use of American standards in the Fire protection Systems in Spanish nuclear power plants implies the use of materials with American certification which leads to difficulties in supply and to cost overruns. The current development of Fire protection standards in Europe opens the possibility of using products with European certification. following is a general comparison between tests on fire-resistant materials, in which it can be seen that the similarities in both standards are more notable than the differences. (Author)

  19. The Management of the Standards: Standards for Accreditation, 199X.

    Science.gov (United States)

    Robbins, Jane B.

    1992-01-01

    This report on the development of the American Library Association's revised standards for master's level programs in library and information studies describes the principal activities preceding the current revision process and details key changes to and retentions from the 1972 Standards. A timetable of remaining steps is included. (NRP)

  20. The effects of body posture, anatomy, age and pregnancy on the calculation of induced current densities at 50 Hz

    International Nuclear Information System (INIS)

    This paper presents calculations of the induced current density in the body at 50 Hz from applied electric and magnetic fields. An extensive ensemble of 25 voxel models has been used to investigate the effects of body posture, anatomy, age and pregnancy. This set includes six adult models, eight child models and seven pregnant female models at various stages of gestation. The four postures investigated in the HPA adult model, NORMAN, were the standard position with the arms at the side, with the arms vertically above the head, the arms horizontally to the side and sitting. (authors)

  1. 从体质测试标准的演变探讨现行标准的可行性%A discussion on the current standards’feasibility from the evolution of physical fitness test standards

    Institute of Scientific and Technical Information of China (English)

    阴欢; 陈棣

    2016-01-01

    对建国后不同时期的体育锻炼标准的出台背景、标准的测试项目及各标准及格成绩进行分析,论述标准的演变过程,揭示标准之间存在的内在联系,并从对比中找出《国家学生体质健康标准》(2014修订版)实施的可行性与不足之处,旨在为加强现代学校体育的教育工作及提高我国体质健康水平提供参考。%Through comparatively analyzed the background of establishment of physical fitness test standards in different era after the founding of new China, including test events and the evolution of pass standards, this article uncovers their inner link, and finds out the feasibility and shortages of the National Student Physical Health Standards(2014 Revision) from comparative study, in order to strengthen our modern school physical education teaching and develop our students’health level.

  2. Generalized Quantum Current Algebras

    Institute of Scientific and Technical Information of China (English)

    ZHAO Liu

    2001-01-01

    Two general families of new quantum-deformed current algebras are proposed and identified both as infinite Hopf family of algebras, a structure which enables one to define "tensor products" of these algebras. The standard quantum affine algebras turn out to be a very special case of the two algebra families, in which case the infinite Hopf family structure degenerates into a standard Hopf algebra. The relationship between the two algebraic families as well as thefr various special examples are discussed, and the free boson representation is also considered.

  3. Characteristics and Outcomes of Young Adult Opiate Users Receiving Residential Substance Abuse Treatment.

    Science.gov (United States)

    Morse, Siobhan; MacMaster, Samuel

    2015-01-01

    Opiate use patterns, user characteristics, and treatment response among young adults are of interest due to current high use prevalence and historical low levels of treatment engagement relative to older populations. Prior research in this population suggests that overall, young adults present at treatment with different issues. In this study the authors investigated potential differences between young adult (18-25 years of age) and older adult (26 and older) opiate users and the impact of differences relative to treatment motivation, length and outcomes. Data for this study was drawn from 760 individuals who entered voluntary, private, residential treatment. Study measures included the Addiction Severity Index (ASI), the Treatment Service Review (TSR), and University of Rhode Island Change Assessment (URICA). Interviews were conducted at program intake and 6-month post-discharge. Results indicate that older adults with a history of opiate use present at treatment with higher levels of severity for alcohol, medical, and psychological problems and young adults present at treatment with greater drug use and more legal issues. Significant improvement for both groups was noted at 6 months post treatment; there were also fewer differences between the two age groups of opiate users. Results suggest different strategies within treatment programs may provide benefit in targeting the disparate needs of younger opiate users. Overall, however, results suggest that individualized treatment within a standard, abstinence-based, residential treatment model can be effective across opiate users at different ages and with different issues, levels of severity, and impairment at intake. PMID:25879396

  4. Adult Immunization

    Directory of Open Access Journals (Sweden)

    Omer Coskun

    2008-04-01

    Full Text Available Despite the many advances in modern medicine, each year thousands of people in the world die from diseases that are easily prevented by safe and effective vaccines. Few measures in preventive medicine are of such proven value and as easy to implement as routine immunization against infectious diseases. Prevention of infection by immunization is a lifelong process. There are a number of vaccines that all adults (¡I18 years require. There are also other vaccines that need to be tailored to meet individual variations in risk resulting from occupation, foreign travel, underlying illness, lifestyle and age. In this study, we tried to review this important subject. [TAF Prev Med Bull. 2008; 7(2: 159-166

  5. Adult Immunization

    Directory of Open Access Journals (Sweden)

    Omer Coskun

    2008-04-01

    Full Text Available Despite the many advances in modern medicine, each year thousands of people in the world die from diseases that are easily prevented by safe and effective vaccines. Few measures in preventive medicine are of such proven value and as easy to implement as routine immunization against infectious diseases. Prevention of infection by immunization is a lifelong process. There are a number of vaccines that all adults (¡I18 years require. There are also other vaccines that need to be tailored to meet individual variations in risk resulting from occupation, foreign travel, underlying illness, lifestyle and age. In this study, we tried to review this important subject. [TAF Prev Med Bull 2008; 7(2.000: 159-166

  6. Neutral currents

    International Nuclear Information System (INIS)

    The evidence for the existence of weak neutral current has been a very controverted topics in the early 1970's, as well as the muon did in the 1930's. The history is very rich considering the evolution of the experimental techniques in high energy particle physics. The history of the discovery and the study of weak neutral current is reviewed. Later the quest of the intermediate vector boson continues with the decision of the community to build a large proton antiproton collider. (K.A.). 14 refs., 1 fig

  7. The New Standards for Learning

    Science.gov (United States)

    Cohen, Jonathan

    2010-01-01

    Current education standards focus narrowly on reading, math, and science learning. As fundamentally important as those standards are, they do not incorporate the essential social, emotional, ethical, and civic dimensions of student learning. School climate does. A growing number of districts and state departments of education are in the process of…

  8. Standards development status. Summary report

    International Nuclear Information System (INIS)

    The Standards Development Status Summary Report is designed for scheduling, monitoring, and controlling the process by which Regulatory Standards, Guides, Reports, Petitions, and Environmental Statements are written. It is a summary of the current schedule plans for development of the above products

  9. Standard deviations

    CERN Document Server

    Smith, Gary

    2015-01-01

    Did you know that having a messy room will make you racist? Or that human beings possess the ability to postpone death until after important ceremonial occasions? Or that people live three to five years longer if they have positive initials, like ACE? All of these ‘facts' have been argued with a straight face by researchers and backed up with reams of data and convincing statistics.As Nobel Prize-winning economist Ronald Coase once cynically observed, ‘If you torture data long enough, it will confess.' Lying with statistics is a time-honoured con. In Standard Deviations, ec

  10. Treatment of Acute Myeloid Leukemia in Adolescent and Young Adult Patients

    Directory of Open Access Journals (Sweden)

    Guldane Cengiz Seval

    2015-03-01

    Full Text Available The objectives of this review were to discuss standard and investigational treatment strategies for adolescent and young adult with acute myeloid leukemia, excluding acute promyelocytic leukemia. Acute myeloid leukemia (AML in adolescent and young adult patients (AYAs may need a different type of therapy than those currently used in children and older patients. As soon as AML is diagnosed, AYA patient should be offered to participate in well-designed clinical trials. The standard treatment approach for AYAs with AML is remission induction chemotherapy with an anthracycline/cytarabine combination, followed by either consolidation chemotherapy or stem cell transplantation, depending on the ability of the patient to tolerate intensive treatment and cytogenetic features. Presently, continuing progress of novel drugs targeting specific pathways in acute leukemia may bring AML treatment into a new era.

  11. Current Titles

    Energy Technology Data Exchange (ETDEWEB)

    Various

    2006-06-01

    This booklet is published for those interested in current research being conducted at the National Center for Electron Microscopy. The NCEM is a DOE-designated national user facility and is available at no charge to qualified researchers. Access is controlled by an external steering committee. Interested researchers may contact Jane Cavlina, Administrator, at 510/486-6036.

  12. Handover standards.

    Science.gov (United States)

    2016-05-01

    An important part of discharge communication is the timely handover of information about diagnostic tests, as breakdown in this aspect of communication can contribute to unsafe patient care. NHS England has produced a set of standards to underpin the development of robust systems of care, policies and practice for the safe and high quality transfer of information about diagnostic tests and test results at discharge. The standards are governed by three overarching principles that have implications for nurses. They are that: ■ Clinicians who order tests are responsible for reviewing, acting on and communicating results and actions taken to GPs and patients, even if patients have been discharged. ■ Results received by GP practices should be reviewed and acted on by a responsible clinician even if they did not order the tests. ■ Reasonable adjustments should be made for people with learning disabilities and mental health problems and, where appropriate, families, carers, care co-ordinators and key workers should be invited to participate in handover processes and decisions about patients at discharge. PMID:27138516

  13. Brain tumor - primary - adults

    Science.gov (United States)

    ... Vestibular schwannoma (acoustic neuroma) - adults; Meningioma - adults; Cancer - brain tumor (adults) ... Primary brain tumors include any tumor that starts in the brain. Primary brain tumors can start from brain cells, ...

  14. Brain tumor - primary - adults

    Science.gov (United States)

    ... Vestibular schwannoma (acoustic neuroma) - adults; Meningioma - adults; Cancer - brain tumor (adults) ... wireless devices Head injuries Smoking Hormone therapy SPECIFIC TUMOR TYPES Brain tumors are classified depending on: Location of the ...

  15. Adult Still's disease

    Science.gov (United States)

    Still's disease - adult; AOSD ... than 1 out of 100,000 people develop adult-onset Still's disease each year. It affects women more often than men. The cause of adult Still's disease is unknown. No risk factors for ...

  16. Human Metapneumovirus in Adults

    Directory of Open Access Journals (Sweden)

    Lenneke E. M. Haas

    2013-01-01

    Full Text Available Human metapneumovirus (HMPV is a relative newly described virus. It was first isolated in 2001 and currently appears to be one of the most significant and common human viral infections. Retrospective serologic studies demonstrated the presence of HMPV antibodies in humans more than 50 years earlier. Although the virus was primarily known as causative agent of respiratory tract infections in children, HMPV is an important cause of respiratory infections in adults as well. Almost all children are infected by HMPV below the age of five; the repeated infections throughout life indicate transient immunity. HMPV infections usually are mild and self-limiting, but in the frail elderly and the immunocompromised patients, the clinical course can be complicated. Since culturing the virus is relatively difficult, diagnosis is mostly based on a nucleic acid amplification test, such as reverse transcriptase polymerase chain reaction. To date, no vaccine is available and treatment is supportive. However, ongoing research shows encouraging results. The aim of this paper is to review the current literature concerning HMPV infections in adults, and discuss recent development in treatment and vaccination.

  17. Human metapneumovirus in adults.

    Science.gov (United States)

    Haas, Lenneke E M; Thijsen, Steven F T; van Elden, Leontine; Heemstra, Karen A

    2013-01-01

    Human metapneumovirus (HMPV) is a relative newly described virus. It was first isolated in 2001 and currently appears to be one of the most significant and common human viral infections. Retrospective serologic studies demonstrated the presence of HMPV antibodies in humans more than 50 years earlier. Although the virus was primarily known as causative agent of respiratory tract infections in children, HMPV is an important cause of respiratory infections in adults as well. Almost all children are infected by HMPV below the age of five; the repeated infections throughout life indicate transient immunity. HMPV infections usually are mild and self-limiting, but in the frail elderly and the immunocompromised patients, the clinical course can be complicated. Since culturing the virus is relatively difficult, diagnosis is mostly based on a nucleic acid amplification test, such as reverse transcriptase polymerase chain reaction. To date, no vaccine is available and treatment is supportive. However, ongoing research shows encouraging results. The aim of this paper is to review the current literature concerning HMPV infections in adults, and discuss recent development in treatment and vaccination. PMID:23299785

  18. Determination of diagnostic reference levels in Cote d'Ivoire: the cases of the chest X-ray standard front and abdomen adult in the district of Abidjan and in the region of Sud Comoé

    International Nuclear Information System (INIS)

    Entrance surface dose measurements were performed for 194 adults using Thermoluminescent Dosimeters (TLD) placed on a 10 liters cane of water, during the X-rays examinations of the chest of face and abdomen at the Institut of Cardiology of Abidjan (District of Abidjan), at the Regional Hospital complex of Aboisso and at the General Hospital of Ayamé (Region of Sud Comoé). This preliminary study, the first one in Cote d'Ivoire, was to assess doses released to patients during their exposure to X-rays in medical radiology with various radiological practices in order to determine the national diagnostic reference levels (DRL) . The results show that the irradiation levels in the selected services are comparable to the dose levels indicated by international publications. They give us a glimpse on doses received in Cote d'Ivoire and show that these initial values of DRL measured are acceptable in the District of Abidjan and in the region of Sud Comoé. This study proves the feasibility and the great interest of a national campaign of measurements in radiology in all the hospitals of the country. This permits to determine ivorian DRL and facilitate their periodic review. (author)

  19. 我国肉蛋制品质量安全标准现状与建议%Current situation and suggestions on quality and safety standard of meat and eggs products in China

    Institute of Scientific and Technical Information of China (English)

    周永昌; 黎华; 周志远

    2012-01-01

    The production and consumption of meat and years. But according to the requirement of food safety law problems about quality and safety standard of meat standard of meat and eggs products were analyzed in forward. eggs in China rank first in the world for 22 and the actual production conditions, some and eggs products still exist in China. Problem in this article and some reasonable suggestions were put%我国在肉蛋生产和消费方面已连续22年居世界第一,但根据《食品安全法》要求和生产实际情况,我国内蛋制品质量安全标准还存在一些问题亟待解决。文章分析了我国肉蛋制品标准存在的部分问题,并针对这些问题提出了一些合理的建议。

  20. International Standardization Activities for Optical Amplifiers

    Institute of Scientific and Technical Information of China (English)

    Haruo Okamura

    2003-01-01

    International standardization activities for Optical Amplifiers at IECTC86 and ITU-T SG15 are reviewed. Current discussions include Optical Amplifier safety guideline, Reliability standard, Rest methods of Noise and PMD, Definitions of Raman amplifier parameters and OA classification.

  1. Neutral Current $\

    CERN Document Server

    Chauhan, S; Singh, S K

    2011-01-01

    We calculate cross sections for the neutral current induced neutrino/antineutrino reaction from $^{208}Pb$ target and applied it to study Supernova neutrino event rates. The calculations are done in local density approximation taking into account Pauli blocking, Fermi motion effects and renormalization of weak transition strengths in the nuclear medium. The numerical results for the neutrino nucleus total cross sections have been averaged over the various Supernova neutrino/antineutrino fluxes available in literature.

  2. The History of the Democratic Adult Education Movement in Spain

    Science.gov (United States)

    Oliver, Esther; Tellado, Itxaso; Yuste, Montserrat; Larena-Fernández, Rosa

    2016-01-01

    Background/Context: Traditional adult education in Spain treated the learner as a mere object that could be shaped by the educator. Although current practices of the democratic adult education movement in Spain reveals a completely opposite standpoint on adult education, there has been little analysis of the several influences converging and…

  3. Using the Pragmatic Progressive Philosophy in Adult Education

    Science.gov (United States)

    Ellis, Marsha L.

    2012-01-01

    Using a pragmatic approach of progressive philosophy when educating adult learners utilizes the knowledge of history, to connect reality with current experiences through facilitated learning. The purpose of this paper is an attempt to show how adult education that uses a pragmatic progressive philosophy encompasses adult experiences,…

  4. Imaging of adult brainstem gliomas

    International Nuclear Information System (INIS)

    Highlights: •BSG are classified on MRI into diffuse low-grade, malignant, focal tectal and exophytic subtypes. •Their prognosis and treatment is variable and is almost similar to adult supratentorial gliomas. •This article illustrates the imaging of adult BSGs on MRI and FET-PET. •We also describe prognostic factors and the treatment options of these tumours. -- Abstract: Brainstem gliomas (BSGs) are uncommon in adults accounting for about 2% of all intracranial neoplasms. They are often phenotypically low-grade as compared to their more common paediatric counterparts. Since brainstem biopsies are rarely performed, these tumours are commonly classified according to their MR imaging characteristics into 4 subgroups: (a) diffuse intrinsic low-grade gliomas, (b) enhancing malignant gliomas, (c) focal tectal gliomas and (d) exophytic gliomas/other subtypes. The prognosis and treatment is variable for the different types and is almost similar to adult supratentorial gliomas. Radiotherapy (RT) with adjuvant chemotherapy is the standard treatment of diffuse low-grade and malignant BSGs, whereas, surgical resection is limited to the exophytic subtypes. Review of previous literature shows that the detailed imaging of adult BSGs has not received significant attention. This review illustrates in detail the imaging features of adult BSGs using conventional and advanced MR techniques like diffusion weighted imaging (DWI), diffusion tensor imaging (DTI), MR perfusion weighted imaging (PWI), MR spectroscopy (MRS), as well as 18F-fluoro-ethyl-tyrosine positron emission tomography (18F-FET/PET). We have discussed the pertinent differences between childhood and adult BSGs, imaging mimics, prognostic factors and briefly reviewed the treatment options of these tumours

  5. Imaging of adult brainstem gliomas

    Energy Technology Data Exchange (ETDEWEB)

    Purohit, Bela, E-mail: purohitbela@yahoo.co.in; Kamli, Ali A.; Kollias, Spyros S.

    2015-04-15

    Highlights: •BSG are classified on MRI into diffuse low-grade, malignant, focal tectal and exophytic subtypes. •Their prognosis and treatment is variable and is almost similar to adult supratentorial gliomas. •This article illustrates the imaging of adult BSGs on MRI and FET-PET. •We also describe prognostic factors and the treatment options of these tumours. -- Abstract: Brainstem gliomas (BSGs) are uncommon in adults accounting for about 2% of all intracranial neoplasms. They are often phenotypically low-grade as compared to their more common paediatric counterparts. Since brainstem biopsies are rarely performed, these tumours are commonly classified according to their MR imaging characteristics into 4 subgroups: (a) diffuse intrinsic low-grade gliomas, (b) enhancing malignant gliomas, (c) focal tectal gliomas and (d) exophytic gliomas/other subtypes. The prognosis and treatment is variable for the different types and is almost similar to adult supratentorial gliomas. Radiotherapy (RT) with adjuvant chemotherapy is the standard treatment of diffuse low-grade and malignant BSGs, whereas, surgical resection is limited to the exophytic subtypes. Review of previous literature shows that the detailed imaging of adult BSGs has not received significant attention. This review illustrates in detail the imaging features of adult BSGs using conventional and advanced MR techniques like diffusion weighted imaging (DWI), diffusion tensor imaging (DTI), MR perfusion weighted imaging (PWI), MR spectroscopy (MRS), as well as {sup 18}F-fluoro-ethyl-tyrosine positron emission tomography ({sup 18}F-FET/PET). We have discussed the pertinent differences between childhood and adult BSGs, imaging mimics, prognostic factors and briefly reviewed the treatment options of these tumours.

  6. Current titles

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1995-07-01

    This booklet is published for those interested in current research being conducted at the National Center for Electron Microscopy. The NCEM is a DOE-designated national user facility and is available at no charge to qualified researchers. Access is controlled by an external steering committee. Interested researchers may contact Gretchen Hermes at (510) 486-5006 or address below for a User`s Guide. Copies of available papers can be ordered from: Theda Crawford National Center for Electron Microscopy, Lawrence Berkeley Laboratory, One Cyclotron Rd., MS72, Berkeley, California, USA 94720.

  7. The Vocational Turn in Adult Literacy Education and the Impact of the International Adult Literacy Survey

    Science.gov (United States)

    Druine, Nathalie; Wildemeersch, Danny

    2000-09-01

    The authors critically examine some of the underlying epistemological and theoretical assumptions of the IALS. In doing so, they distinguish among two basic orientations towards literacy. First, the standard approach (of which IALS is an example) subscribes to the possibility of measuring literacy as abstract, cognitive skills, and endorses the claim that there is an important relationship between literacy skills and economic success in the so-called 'knowledge society.' The second, called a socio-cultural approach, insists on the contextual and power-related character of people's literacy practices. The authors further illustrate that the assumptions of the IALS are rooted in a neo-liberal ideology that forces all members of society to adjust to the exigencies of the globalised economy. In the current, contingent conditions of the risk society, however, it does not seem very wise to limit the learning of adults to enhancing labour-market competencies. Adult education should relate to the concrete literacy practices people already have in their lives. It should make its learners co-responsible actors of their own learning process and participants in a democratic debate on defining the kind of society people want to build.

  8. Current ornithology

    CERN Document Server

    1983-01-01

    The appearance of the first volume of a projected series is the occasion for comment on scope, aims, and genesis of the work. The scope of Current Ornithology is all of the biology of birds. Ornithology, as a whole-organism science, is concerned with birds at every level of bi­ ological organization, from the molecular to the community, at least from the Jurassic to the present time, and over every scholarly discipline in which bird biology is done; to say this is merely to expand a dic­ tionary definition of "ornithology. " The aim of the work, to be realized over several volumes, is to present reviews or position statements con­ cerning the active fields of ornithological research. The reviews will be relatively short, and often will be done from the viewpoint of a readily­ identified group or school. Such a work could have come into being at any time within the past fifty years, but that Current Ornithology appears now is a result of events that are only seven to eight years old. One important event wa...

  9. Cognitive Consequences of Expressive Regulation in Older Adults

    OpenAIRE

    Emery, Lisa; Hess, Thomas M

    2011-01-01

    Previous research has suggested that older and young adults are equally able to regulate their outward expressions of emotion and that the regulation of emotional expression in younger adults results in decreased memory for the emotional stimulus. In the current study, we examined whether older adults show this same memory effect. Older and young adults viewed positive and negative emotional pictures under instructions to view the pictures naturally, enhance their facial expressions, or suppr...

  10. Qualification paths of adult educators in Sweden and Denmark

    DEFF Research Database (Denmark)

    Andersson, Per; Köpsén, Susanne; Larson, Anne;

    2013-01-01

    fields of education and training. In this study, we analyse the qualification paths, or learning trajectories, of prospective adult educators in Sweden and Denmark. The analysis is based on narrative interviews with 29 students in training to become adult educators. The career paths of adult educators......The qualification of adult educators is a central aspect of the quality of adult education. However, within current policy discourses and adult education research on the professional development of prospective adult educators, little attention is paid to teacher qualification when compared to other...... and the relation to the learners is part of the professional development. Finally, we argue that both academic studies and hands-on work in the adult education community are crucial parts of the adult educator’s qualification path....

  11. Complexity of childhood sexual abuse: predictors of current post-traumatic stress disorder, mood disorders, substance use, and sexual risk behavior among adult men who have sex with men.

    Science.gov (United States)

    Boroughs, Michael S; Valentine, Sarah E; Ironson, Gail H; Shipherd, Jillian C; Safren, Steven A; Taylor, S Wade; Dale, Sannisha K; Baker, Joshua S; Wilner, Julianne G; O'Cleirigh, Conall

    2015-10-01

    Men who have sex with men (MSM) are the group most at risk for HIV and represent the majority of new infections in the United States. Rates of childhood sexual abuse (CSA) among MSM have been estimated as high as 46 %. CSA is associated with increased risk of HIV and greater likelihood of HIV sexual risk behavior. The purpose of this study was to identify the relationships between CSA complexity indicators and mental health, substance use, sexually transmitted infections, and HIV sexual risk among MSM. MSM with CSA histories (n = 162) who were screened for an HIV prevention efficacy trial completed comprehensive psychosocial assessments. Five indicators of complex CSA experiences were created: CSA by family member, CSA with penetration, CSA with physical injury, CSA with intense fear, and first CSA in adolescence. Adjusted regression models were used to identify relationships between CSA complexity and outcomes. Participants reporting CSA by family member were at 2.6 odds of current alcohol use disorder (OR 2.64: CI 1.24-5.63), two times higher odds of substance use disorder (OR 2.1: CI 1.02-2.36), and 2.7 times higher odds of reporting an STI in the past year (OR 2.7: CI 1.04-7.1). CSA with penetration was associated with increased likelihood of current PTSD (OR 3.17: CI 1.56-6.43), recent HIV sexual risk behavior (OR 2.7: CI 1.16-6.36), and a greater number of casual sexual partners (p = 0.02). Both CSA with Physical Injury (OR 4.05: CI 1.9-8.7) and CSA with Intense Fear (OR 5.16: CI 2.5-10.7) were related to increased odds for current PTSD. First CSA in adolescence was related to increased odds of major depressive disorder. These findings suggest that CSA, with one or more complexities, creates patterns of vulnerabilities for MSM, including post-traumatic stress disorder, substance use, and sexual risk taking, and suggests the need for detailed assessment of CSA and the development of integrated HIV prevention programs that address mental health and

  12. Standards for air monitoring calibration

    International Nuclear Information System (INIS)

    The US Department of Energy and the US Nuclear Regulatory Commission initiated a joint program to test the applicability of a performance-type testing standard. Draft American National Standards Institute (ANSI) Standard N42.17a was, because of difficulty in application, divided into three parts: (a) portable instruments, (b) air monitors, and (c) extended range. This new testing program used the criteria listed in parts a, b, and c to determine whether they could be used as the basis of an instrument qualification testing program. The results of the test were then provided to the standards committee, and appropriate changes were made in the standard. The detailed results of this testing program will be documented in the future. The purpose of this presentation is to discuss the current draft of the air monitoring standard, general test procedures, results of some of the tests, and the means by which the testing program could be implemented in the United States

  13. Adult Neurogenesis in Drosophila

    OpenAIRE

    Ismael Fernández-Hernández; Christa Rhiner; Eduardo Moreno

    2013-01-01

    Adult neurogenesis has been linked to several cognitive functions and neurological disorders. Description of adult neurogenesis in a model organism like Drosophila could facilitate the genetic study of normal and abnormal neurogenesis in the adult brain. So far, formation of new neurons has not been detected in adult fly brains and hence has been thought to be absent in Drosophila. Here, we used an improved lineage-labeling method to show that, surprisingly, adult neurogenesis occurs in the m...

  14. Depression in Older Adults

    OpenAIRE

    Fiske, Amy; Wetherell, Julie Loebach; Gatz, Margaret

    2009-01-01

    Depression is less prevalent among older adults than among younger adults but can have serious consequences. Over half of cases represent a first onset in later life. Although suicide rates in the elderly are declining, they are still higher than in younger adults and more closely associated with depression. Depressed older adults are less likely to endorse affective symptoms and more likely to display cognitive changes, somatic symptoms, and loss of interest than are younger adults. Risk fac...

  15. European consensus statement on diagnosis and treatment of adult ADHD: the European Network adult ADHD

    LENUS (Irish Health Repository)

    Kooij, Sandra JJ

    2010-09-03

    Abstract Background Attention deficit hyperactivity disorder (ADHD) is among the most common psychiatric disorders of childhood that persists into adulthood in the majority of cases. The evidence on persistence poses several difficulties for adult psychiatry considering the lack of expertise for diagnostic assessment, limited treatment options and patient facilities across Europe. Methods The European Network Adult ADHD, founded in 2003, aims to increase awareness of this disorder and improve knowledge and patient care for adults with ADHD across Europe. This Consensus Statement is one of the actions taken by the European Network Adult ADHD in order to support the clinician with research evidence and clinical experience from 18 European countries in which ADHD in adults is recognised and treated. Results Besides information on the genetics and neurobiology of ADHD, three major questions are addressed in this statement: (1) What is the clinical picture of ADHD in adults? (2) How can ADHD in adults be properly diagnosed? (3) How should ADHD in adults be effectively treated? Conclusions ADHD often presents as an impairing lifelong condition in adults, yet it is currently underdiagnosed and treated in many European countries, leading to ineffective treatment and higher costs of illness. Expertise in diagnostic assessment and treatment of ADHD in adults must increase in psychiatry. Instruments for screening and diagnosis of ADHD in adults are available and appropriate treatments exist, although more research is needed in this age group.

  16. Performance in Older Adults

    Directory of Open Access Journals (Sweden)

    David Predovan

    2012-01-01

    Full Text Available Growing evidence supports the use of physical training interventions to improve both physical and cognitive performances in healthy older adults. Few studies have examined the impact of aerobic exercise on Stroop task performance, a measure of executive functions. In the current 3-month aerobic training study, 50 older adults (mean age = 67.96 ± 6.25 years were randomly assigned to either a three-month physical training group or to a control group (waiting list. Training sessions were 3 times per week for 60 minutes. All participants completed pre- and post-test measures of cognitive performance using the modified Stroop task and physical performance (Rockport one-mile test. Compared to controls, the training group showed significant improvements in physical capacity (P<0.001 and enhanced Stroop performance, but only in the inhibition/switching condition (P<0.03. Furthermore, the increase in aerobic capacity induced by the training regimen correlated negatively with reaction time in the inhibition/switching condition of the Stroop task at posttest (r=−0.538; P=0.007. Importantly, the reported gains in cognitive performance were observed after only three months of physical training. Taken together, the results suggest that even short-term physical interventions can enhance older adults’ executive functions.

  17. Neutral currents

    International Nuclear Information System (INIS)

    A short survey of the new experimental data on weak neutral currents is given, followed by a comparison with modern theoretical models. Cross sections of the anti νsub(e)e → anti νsub(e)e, anti νsub(μ)e→ νsub(μ)e, νp → νp and anti νp → anti νp elastic scattering as well as inclusive cross sections of the ν+N → ν+X and anti ν+N → anti ν+X deep inelastic scattering are presented. On the basis of the comparison the Weinberg-Salam model is concluded to be in a good agreement with the shape of the cross sections. Six-quark vector models appear to be ruled out. The five-quark model due to Achiman, Koller and Walsh and two versions of the Gursey-Sikivie model satisfactorily account for the observed data in shape and in magnitude

  18. Adult coeliac disease.

    Science.gov (United States)

    Marmouz, F

    2007-01-01

    Coeliac disease is an auto-immune inflammatory reaction characterized by a partial or total villi's atrophy of the proximal small intestine occuring after ingestion of gluten in genetically predisposed patients. The classic form is much more frequent in children. Thereby there has been a misevaluation and improper treatment of coeliac disease in adults who suffer more from asymptomatica and atypical forms. Currently the only effective treatment is a strict gluten free diet for life. However recent researches brought a new light on the matter. Now oats as a causative factor is controvertial. The introduction of some moderate intestinal lesions (pre-atrophic with intra-epithelial hyperlymphocytosis qualified as "weak enteropathies") in the definition of coeliac disease might be possible. Moreover the way to diagnose has evolved as serological tests and markers are more used due to their efficiency. PMID:17375738

  19. Supporting Academic Persistence in Low-Skilled Adult Learners

    Science.gov (United States)

    O'Neill, Susan; Thomson, Margareta Maria

    2013-01-01

    The current literature review explores the factors that contribute to academic persistence for adult learners. The aim of the study is to identify current research-based strategies aimed at supporting learner persistence, particularly for low-skilled adults. Elements of three theoretical frameworks, namely, expectancy-value theory (EVT), goal…

  20. Clopidogrel Resistance: Current Issues

    Directory of Open Access Journals (Sweden)

    NS Neki

    2016-05-01

    Full Text Available Antiplatelet agents are mainly used in the prevention and management of atherothrombotic complications. Dual antiplatelet therapy, combining aspirin and clopidogrel, is the standard care for patients having acute coronary syndromes or undergoing percutaneous coronary intervention according to the current ACC/AHA and ESC guidelines. But in spite of administration of dual antiplatelet therapy, some patients develop recurrent cardiovascular ischemic events especially stent thrombosis which is a serious clinical problem. Antiplatelet response to clopidogrel varies widely among patients based on ex vivo platelet function measurements. Clopidogrel is an effective inhibitor of platelet activation and aggregation due to its selective and irreversible blockade of the P2Y12 receptor. Patients who display little attenuation of platelet reactivity with clopidogrel therapy are labeled as low or nonresponders or clopidogrel resistant. The mechanism of clopidogrel resistance remains incompletely defined but there are certain clinical, cellular and genetic factors including polymorphisms responsible for therapeutic failure. Currently there is no standardized or widely accepted definition of clopidogrel resistance. The future may soon be realised in the routine measurement of platelet activity in the same way that blood pressure, cholesterol and blood sugar are followed to help guide the therapy, thus improving the care for millions of people. This review focuses on the methods used to identify patients with clopidogrel resistance, the underlying mechanisms, metabolism, clinical significance and current therapeutic strategies to overcome clopidogrel resistance. J Enam Med Col 2016; 6(1: 38-46

  1. Hazard Communication Standard

    International Nuclear Information System (INIS)

    The current rate of technological advances has brought with it an overwhelming increase in the usage of chemicals in the workplace and in the home. Coupled to this increase has been a heightened awareness in the potential for acute and chronic injuries attributable to chemical insults. The Hazard Communication Standard has been introduced with the desired goal of reducing workplace exposures to hazardous substances and thereby achieving a corresponding reduction in adverse health effects. It was created and proclaimed by the US Department of Labor and regulated by the Occupational Safety and Health Administration. 1 tab

  2. PROTEST. Suggestions for improved standards

    Energy Technology Data Exchange (ETDEWEB)

    Holierhoek, J.G. (ed.); Lekou, D.J.; Hecquet, T.; Soeker, H.

    2010-10-15

    The pre-normative PROTEST (PROcedures for TESTing and measuring wind energy systems) project looked at possibilities to improve the current standards by using wind turbine prototype measurements to validate the drive train, pith system and yaw system models. The main conclusions from this project that could be valuable for the standards committees are summarised in this report. These recommendations include new Design Load Cases, measurement procedures for model validation and load measurements at specific interconnection points.

  3. Teleradiology - current status

    International Nuclear Information System (INIS)

    Tele-radiology is a term becoming increasingly popular in the medical literature. Nevertheless, terminological definitions in this particular field are still rather vague. The scope of applications extend from simple image presenting via analogue telephone lines to transmission of 3-D medical images through a satellite. It is a matter of standards highly differing in terms of data transmission rates, safety, technical demands on the systems and the like. In this article new information technologies, technical aspects, as well as some major applications of tele-radiology are discussed. The current status of tele-medicine/tele-radiology in this country is likewise briefly outlined

  4. Clues of subjective social status among young adults.

    Science.gov (United States)

    Nielsen, François; Roos, J Micah; Combs, R M

    2015-07-01

    We investigate determinants of subjective social status (SSS) as measured by respondents placing themselves on a ten-rung ladder from least to most "money", "education" and "respected job", in a large sample of young adults. The most potent clues of SSS are proximate in the life course, reflecting educational attainment and current socioeconomic and job situation, rather than distal characteristics such as family background, although relatively distal High school GPA has a lingering effect. Additional analyses reveal that College selectivity has a substantial impact on SSS, net of other variables in the model; Currently married does not significantly contribute to SSS, but contrary to some expectations Number of children significantly lowers SSS. We find no evidence of greater "status borrowing" by women as associations of SSS with shared household characteristics (Household income, Household assets, Home ownership) do not differ by gender. Our findings for these young adults support the conclusion of earlier research that SSS reflects a "cognitive averaging" of standard dimensions of socioeconomic status. PMID:26004468

  5. Supporting wellness in adult online education

    Directory of Open Access Journals (Sweden)

    Jacklyn J. Thompson

    2014-02-01

    Full Text Available Online education cannot continue to grow at the current pace while ignoring a crucial component of campus support, wellness for adult online learners. This paper brings awareness to the concept of wellness as an important student support service in adult online education. It includes a summarized review of relevant literature and identifies specific wellness concerns of adult online learners. The paper also provides examples of how three American higher education institutions are addressing the issue of wellness promotion in online learning. It identifies areas for improvement in current wellness initiatives and offers recommended strategies for supporting adult online learner wellness to professional organizations, institutions, instructors, and distance learners.http://dx.doi.org/10.5944/openpraxis.6.1.100

  6. Communicating with young adults with cystic fibrosis.

    OpenAIRE

    Webb, A. K.

    1995-01-01

    The care of the young adult with cystic fibrosis is complex, requiring a multidisciplinary input from different carers. Communication with and education of patients covers many areas; topics may include medical and personal problems, transplantation, survival, current scientific breakthroughs and the future. Communicating in these areas with knowledgeable young adults requires skill, tact and self-education upon the part of the cystic fibrosis team.

  7. Atlas C++ Coding Standard Specification

    CERN Document Server

    Albrand, S; Barberis, D; Bosman, M; Jones, B; Stavrianakou, M; Arnault, C; Candlin, D; Candlin, R; Franck, E; Hansl-Kozanecka, Traudl; Malon, D; Qian, S; Quarrie, D; Schaffer, R D

    2001-01-01

    This document defines the ATLAS C++ coding standard, that should be adhered to when writing C++ code. It has been adapted from the original "PST Coding Standard" document (http://pst.cern.ch/HandBookWorkBook/Handbook/Programming/programming.html) CERN-UCO/1999/207. The "ATLAS standard" comprises modifications, further justification and examples for some of the rules in the original PST document. All changes were discussed in the ATLAS Offline Software Quality Control Group and feedback from the collaboration was taken into account in the "current" version.

  8. Darkness beyond the Standard Model

    International Nuclear Information System (INIS)

    With the discovery of the Higgs Boson all particles of the Standard Model of Particle Physics are experimentally identified. However, we know that the Standard Model can not explain all measurements. In particular several astrophysical measurements can not be explained within the Standard Model. A famous shortcoming is the existence of the so-called Dark Matter. A very well motivated candidate for the Dark Matter are WIMPs, weakly interactive massive particles. The current status of WIMP searches and the plans of the new experimental group at the Institute of High Energy Physics are presented. (author)

  9. GH Replacement Therapy in GH-Deficient Adults

    OpenAIRE

    Luger A

    2006-01-01

    Growth hormone (GH) deficiency represents an indication for substitution therapy not only in children but also in adults. In the last twenty years, numerous studies have shown that GH deficiency in adults is characterized by a clearly defined syndrome which is associated with a doubleincreased mortality rate. GH deficiency in adults can be diagnosed only by dynamic tests. While the insulin tolerance test (ITT) has been the standard test in the past, the combined arginine-GH releasing hormon...

  10. Adult vector control, mosquito ecology and malaria transmission.

    OpenAIRE

    Brady, OJ; Godfray, HC; Tatem, AJ; Gething, PW; Cohen, JM; McKENZIE, FE; Alex Perkins, T.; Reiner, RC; Tusting, LS; Scott, TW; Lindsay, SW; Hay, SI; Smith, DL

    2015-01-01

    BACKGROUND: Standard advice regarding vector control is to prefer interventions that reduce the lifespan of adult mosquitoes. The basis for this advice is a decades-old sensitivity analysis of 'vectorial capacity', a concept relevant for most malaria transmission models and based solely on adult mosquito population dynamics. Recent advances in micro-simulation models offer an opportunity to expand the theory of vectorial capacity to include both adult and juvenile mosquito stages in the model...

  11. TESOL Technology Standards: Description, Implementation, Integration

    Science.gov (United States)

    Teachers of English to Speakers of Other Languages, Inc. (TESOL), 2011

    2011-01-01

    The "TESOL Technology Standards" are applicable in a wide range of contexts: foreign language, second language, child, teen, adult, higher education, vocational education, language for specific purposes, and fully online programs; and in settings with low, medium, or high resources and access to communication technologies. Students, teachers,…

  12. Bathroom safety - adults

    Science.gov (United States)

    ... this page: //medlineplus.gov/ency/patientinstructions/000021.htm Bathroom safety - adults To use the sharing features on this page, please enable JavaScript. Older adult bathroom safety What to consider at home Staying safe ...

  13. Older Adults and Depression

    Science.gov (United States)

    ... Older Adults and Depression Share Older Adults and Depression Download PDF Download ePub Download Mobi Order a ... If so, you may have depression. What is depression? Everyone feels down or sad sometimes, but these ...

  14. Does the Current Account Still Matter?

    OpenAIRE

    Maurice Obstfeld

    2012-01-01

    Do global current account imbalances still matter in a world of deep international financial markets where gross two-way financial flows often dwarf the net flows measured in the current account? Contrary to a complete markets or 'consenting adults' view of the world, large current account imbalances, while very possibly warranted by fundamentals and welcome, can also signal elevated macroeconomic and financial stresses, as was arguably the case in the mid-2000s. Furthermore, the increasingly...

  15. Implementing PAT with Standards

    Science.gov (United States)

    Chandramohan, Laakshmana Sabari; Doolla, Suryanarayana; Khaparde, S. A.

    2016-02-01

    Perform Achieve Trade (PAT) is a market-based incentive mechanism to promote energy efficiency. The purpose of this work is to address the challenges inherent to inconsistent representation of business processes, and interoperability issues in PAT like cap-and-trade mechanisms especially when scaled. Studies by various agencies have highlighted that as the mechanism evolves including more industrial sectors and industries in its ambit, implementation will become more challenging. This paper analyses the major needs of PAT (namely tracking, monitoring, auditing & verifying energy-saving reports, and providing technical support & guidance to stakeholders); and how the aforesaid reasons affect them. Though current technologies can handle these challenges to an extent, standardization activities for implementation have been scanty for PAT and this work attempts to evolve them. The inconsistent modification of business processes, rules, and procedures across stakeholders, and interoperability among heterogeneous systems are addressed. This paper proposes the adoption of specifically two standards into PAT, namely Business Process Model and Notation for maintaining consistency in business process modelling, and Common Information Model (IEC 61970, 61968, 62325 combined) for information exchange. Detailed architecture and organization of these adoptions are reported. The work can be used by PAT implementing agencies, stakeholders, and standardization bodies.

  16. Adult educators' core competences

    DEFF Research Database (Denmark)

    Wahlgren, Bjarne

    2016-01-01

    Abstract Which competences do professional adult educators need? This research note discusses the topic from a comparative perspective, finding that adult educators’ required competences are wide-ranging, heterogeneous and complex. They are subject to context in terms of national and cultural env...... profiles, the author notes that adult educators’ ability to train adult learners in a way which then enables them to apply and use what they have learned in practice (thus performing knowledge transfer) still seems to be overlooked....

  17. Adult health checkup

    Science.gov (United States)

    Ridley, Jane; Ischayek, Amanda; Dubey, Vinita; Iglar, Karl

    2016-01-01

    Abstract Objective To describe updates to the Preventive Care Checklist Form© to help family physicians stay up to date with current preventive health care recommendations. Quality of evidence The Ovid MEDLINE database was searched using specified key words and other terms relevant to the periodic health examination. Secondary sources, such as the Canadian Task Force on Preventive Health Care, the Public Health Agency of Canada, the Trip database, and the Canadian Medical Association Infobase, were also searched. Recommendations for preventive health care for average-risk adults were reviewed. Strong and weak recommendations are presented on the form in bold and italic text, respectively. Main message Updates were made to the form based on the Canadian Task Force on Preventive Health Care recommendations on screening for obesity (2015), cervical cancer (2013), depression (2013), osteoporosis (2013), hypertension (2012), diabetes (2012, 2013), and breast cancer (2011). Updates were made based on recommendations from other Canadian organizations on screening for HIV (2013), screening for sexually transmitted infections (2013), immunizations (2012 to 2014), screening for dyslipidemia (2012), fertility counseling for women (2011, 2012), and screening for colorectal cancer (2010). Some previous recommendations were removed and others lacking evidence were not included. Conclusion The Preventive Care Checklist Form has been updated with current recommendations to enable family physicians to provide comprehensive, evidence-based care to patients during periodic health examinations. PMID:27076540

  18. Understanding Innovation: Youth-Adult Partnerships in Decision Making

    Science.gov (United States)

    Zeldin, Shepherd; Petrokubi, Julie

    2006-01-01

    In the United States, the concept of youth-adult partnership remains innovative. The notion that youth and adults can collaborate on issues of importance runs counter to prevailing societal norms, public policies, structures and standards of practice. There is not much cultural or policy support for managers seeking to integrate youth-adult…

  19. Mental Health Problems in Adults with Williams Syndrome

    Science.gov (United States)

    Stinton, Chris; Elison, Sarah; Howlin, Patricia

    2010-01-01

    Although many researchers have investigated emotional and behavioral difficulties in individuals with Williams syndrome, few have used standardized diagnostic assessments. We examined mental health problems in 92 adults with Williams syndrome using the Psychiatric Assessment Schedule for Adults with Developmental Disabilities--PAS-ADD (Moss,…

  20. Development of False Memories in Bilingual Children and Adults

    Science.gov (United States)

    Howe, Mark L.; Gagnon, Nadine; Thouas, Lisa

    2008-01-01

    The effects of within- versus between-languages (English-French) study and test on rates of bilingual children's and adults' true and false memories were examined. Children aged 6 through 12 and university-aged adults participated in a standard Deese-Roediger-McDermott false memory task using free recall and recognition. Recall results showed…

  1. Dividing Attention Lowers Children's but Increases Adults' False Memories

    Science.gov (United States)

    Otgaar, Henry; Peters, Maarten; Howe, Mark L.

    2012-01-01

    The present study examined the impact of divided attention on children's and adults' neutral and negative true and false memories in a standard Deese/Roediger-McDermott paradigm. Children (7- and 11-year-olds; n = 126) and adults (n = 52) received 5 neutral and 5 negative Deese/Roediger-McDermott word lists; half of each group also received a…

  2. Global Adult Tobacco Survey Data as a Tool to Monitor the WHO Framework Convention on Tobacco Control (WHO FCTC) Implementation: The Brazilian Case

    OpenAIRE

    Roberta Caixeta; Deborah Malta; Moysés Szklo; Luís Felipe Martins; Mirian Souza; Mariana Sampaio; André Szklo; Liz Almeida

    2012-01-01

    The Global Adult Tobacco Survey (GATS) was conducted in Brazil to provide data on tobacco use in order to monitor the WHO FCTC implementation in the country. It was carried out in 2008 using an international standardized methodology. The instrument included questions about tobacco use prevalence, cessation, secondhand smoke, knowledge, attitudes, media and advertising. Weighted analysis was used to obtain estimates. A total of 39,425 interviews were conducted. The prevalence of current tobacc...

  3. Adult Survival Skills Assessment.

    Science.gov (United States)

    Walsko, Gregory M.

    The purpose of this instrument is to supplement data from the Adult Basic Learning Examination in assessing the functional level of adults in daily situations. It may also be used as a teaching tool for adults requesting tutoring in specific concepts and skills presented in the instrument. This instrument is an informal assessment instrument and…

  4. Adult Learning Assumptions

    Science.gov (United States)

    Baskas, Richard S.

    2011-01-01

    The purpose of this study is to examine Knowles' theory of andragogy and his six assumptions of how adults learn while providing evidence to support two of his assumptions based on the theory of andragogy. As no single theory explains how adults learn, it can best be assumed that adults learn through the accumulation of formal and informal…

  5. Adult Education in Turkey

    Science.gov (United States)

    Miser, Rifat; Ural, Ozana; Ünlühisarýklý, Özlem

    2013-01-01

    This study investigates the situation and practices of adult education in Turkey in terms of (a) participants, (b) providers, and (c) program areas. The data were derived from published statistical data and one-to-one interaction with adult education providers when such data are unavailable. Turkey has a long tradition of adult education with…

  6. Adults Role in Bullying

    Science.gov (United States)

    Notar, Charles E.; Padgett, Sharon

    2013-01-01

    Do adults play a role in bullying? Do parents, teachers, school staff, and community adult leaders influence bullying behavior in children and teenagers? This article will focus on research regarding all adults who have almost daily contact with children and teens and their part in how bullying is identified, addressed, and prevented. This article…

  7. Sexuality in Older Adults

    Science.gov (United States)

    MENU Return to Web version Sexuality in Older Adults Sexuality in Older Adults What are the benefits of a healthy sex life for older adults? Sex is ... concerns, and acknowledge new relationships with respect. Bibliography Sexuality in Later Life by National Institute on Aging ( ...

  8. Current status in diabetic macular edema treatments.

    Science.gov (United States)

    Romero-Aroca, Pedro

    2013-10-15

    Diabetes is a serious chronic condition, which increase the risk of cardiovascular diseases, kidney failure and nerve damage leading to amputation. Furthermore the ocular complications include diabetic macular edema, is the leading cause of blindness among adults in the industrialized countries. Today, blindness from diabetic macular edema is largely preventable with timely detection and appropriate interventional therapy. The treatment should include an optimized control of glycemia, arterial tension, lipids and renal status. The photocoagulation laser is currently restricted to focal macular edema in some countries, but due the high cost of intravitreal drugs, the use of laser treatment for focal and diffuse diabetic macular edema (DME), can be valid as gold standard in many countries. The intravitreal anti vascular endothelial growth factor drugs (ranibizumab and bevacizumab), are indicated in the treatment of all types of DME, but the correct protocol for administration should be defined for the different Retina Scientific Societies. The corticosteroids for diffuse DME, has a place in pseudophakic patients, but its complications restricted the use of these drugs for some patients. Finally the intravitreal interface plays an important role and its exploration is mandatory in all DME patients. PMID:24147200

  9. Current status in diabetic macular edema treatments

    Institute of Scientific and Technical Information of China (English)

    Pedro; Romero-Aroca

    2013-01-01

    Diabetes is a serious chronic condition,which increase the risk of cardiovascular diseases,kidney failure and nerve damage leading to amputation.Furthermore the ocular complications include diabetic macular edema,is the leading cause of blindness among adults in the industrialized countries.Today,blindness from diabetic macular edema is largely preventable with timely detection and appropriate interventional therapy.The treatment should include an optimized control of glycemia,arterial tension,lipids and renal status.The photocoagulation laser is currently restricted to focal macular edema in some countries,but due the high cost of intravitreal drugs,the use of laser treatment for focal and diffuse diabetic macular edema(DME),can be valid as gold standard in many countries.The intravitreal anti vascular endothelial growth factor drugs(ranibizumab and bevacizumab),are indicated in the treatment of all types of DME,but the correct protocol for administration should be defined for the different Retina Scientific Societies.The corticosteroids for diffuse DME,has a place in pseudophakic patients,but its complications restricted the use of these drugs for some patients.Finally the intravitreal interface plays an important role and its exploration is mandatory in all DME patients.

  10. Application Guideline for Vitamin D and Bone Health in Adult Chinese(2014 Standard Edition) Vitamin D Working Group of Osteoporosis Committee of China Gerontological Society%维生素D与成年人骨骼健康应用指南(2014年标准版)

    Institute of Scientific and Technical Information of China (English)

    廖祥鹏; 张增利; 张红红; 朱汉民; 周建烈; 黄琪仁; 汪之顼; 王亮; 刘忠厚

    2014-01-01

    Vitamin D may contribute to widespread effects in human health, and vitamin D deficiency may lead to the development of osteoporosis, and to falls and fractures;meanwhile, there have been some conflicting guidelines and inconsistent practices about vitamin D in the West.Given these conditions, some specialists from Osteoporosis Committee of China Gerontological Society develop this practical application guideline for vitamin D and bone health in adult Chinese.This guideline includes“Starter Edition”and“Standard Edition”, and the evidence of this guideline mainly comes from the guideline of National Osteoporosis Society in the UK (2013), the report of Institute of Medicine in the United States (2011), supported by some domestic literatures.This guideline addresses the management of vitamin D deficiency in adult patients with, or at risk of developing, bone disease.It should be noted that the management of vitamin D deficiency in childhood, in pregnancy or in patients with severe or end-stage chronic kidney disease (CKD Stages 4-5) is beyond the topic of this guideline.Based on the published"Starter Edition"in this journal, this"Standard Edition"goes further;and the contents of this guideline includes the setting up of vitamin D thresholds for adult Chinese, assessment of vitamin D status, interpretation of 25OHD measurement, detailed plan of vitamin D treatment and monitoring, and prevention strategy for vitamin D deficiency.%维生素D对人体健康产生广泛作用,维生素D缺乏症( Vitamin D deficiency)可能会导致骨质疏松症进展、跌倒和骨折;同时,在西方国家出现了不一致维生素D标准和实践方案。鉴于此,中国老年学会骨质疏松委员会相关专业人员,制定了《维生素D与成年人骨骼健康应用指南》。该《指南》分为《简化版》和《标准版》,主要证据来源于2013年英国骨质疏松学会指南、2011年美国健康研究院报告,以及国内文献。该

  11. CURRENT ACCOUNTING DEVELOPMENTS IN KOSOVO

    OpenAIRE

    NEXHMIE VOKSHI; MIHANE BERISHA-NAMANI

    2011-01-01

    For the study of the developments in accounting in Kosovo and its prospects, it is necessary to review the current situation of the developments in accounting, the recognition and acceptance of accounting standards. It is clear that the actual and perspective development level in an affected by many factors, such as social, cultural, etc. Therefore, the main aim of the research work in this study is to give an overview of the current developments of accounting in Kosovo. To obtain the require...

  12. Hepatoblastoma of the adult: A systematic review of the literature.

    Science.gov (United States)

    Celotti, Andrea; D'Amico, Giuseppe; Ceresoli, Marco; Tomasoni, Matteo; Raimondo, Stefano; Baggi, Paolo; Baiocchi, Gian Luca

    2016-09-01

    Hepatoblastoma is the most common malignant liver tumor in children. On the other hand in the adult HB is very rare and characterized by unfavorable prognosis. A review of the entire literature was performed: 58 articles and 63 cases of HB were found. The patient's data were collected and analyzed. No correlation with hepatitis virus was found and AFP was elevated in most cases. Usually HB forms a large single mass in the liver and presents aggressive behavior, with local invasiveness and metastatic spread. The current median survival time is 5 months, with a 1-year survival rate near 30%. Surgical resection is the only curative treatment. However major liver resections or extensive demolitions of the adjacent organs are necessary. There are no standardized protocols in the multimodal approach to this tumor. PMID:27566042

  13. Suicide attempts in 107 adolescents and adults with kleptomania

    DEFF Research Database (Denmark)

    Odlaug, Brian Lawrence; Grant, Jon E; Kim, Suck Won

    2012-01-01

    Suicide attempts in kleptomania have received little investigation. This study examined rates, correlates, and predictors of suicide attempts in kleptomania. A total of 107 adolescent and adult subjects (n = 32 [29.9%] males) with DSM-IV kleptomania were assessed with standard measures of symptom...... severity, psychiatric comorbidity, and functional impairment. Subjects had high rates of suicide attempts (24.3%). The suicide attempt in 92.3% of those who attempted suicide was attributed specifically to kleptomania. Suicide attempts were associated with current and life-time bipolar disorder (p = .047......) and lifetime personality disorder (p = .049). Individuals with kleptomania have high rates of suicide attempts. Bipolar disorder is associated with suicide attempts in individuals with kleptomania and underscores the importance of carefully assessing and monitoring suicidality in patients with...

  14. Obsessive Compulsive Disorder among Adults

    Science.gov (United States)

    ... Children Autism Spectrum Disorder (ASD) Eating Disorders Among Adults - Anorexia Nervosa Eating Disorders Among Adults - Binge Eating Disorder Eating ... Children Autism Spectrum Disorder (ASD) Eating Disorders Among Adults - Anorexia Nervosa Eating Disorders Among Adults - Binge Eating Disorder Eating ...

  15. Standardized food images: A photographing protocol and image database.

    Science.gov (United States)

    Charbonnier, Lisette; van Meer, Floor; van der Laan, Laura N; Viergever, Max A; Smeets, Paul A M

    2016-01-01

    The regulation of food intake has gained much research interest because of the current obesity epidemic. For research purposes, food images are a good and convenient alternative for real food because many dietary decisions are made based on the sight of foods. Food pictures are assumed to elicit anticipatory responses similar to real foods because of learned associations between visual food characteristics and post-ingestive consequences. In contemporary food science, a wide variety of images are used which introduces between-study variability and hampers comparison and meta-analysis of results. Therefore, we created an easy-to-use photographing protocol which enables researchers to generate high resolution food images appropriate for their study objective and population. In addition, we provide a high quality standardized picture set which was characterized in seven European countries. With the use of this photographing protocol a large number of food images were created. Of these images, 80 were selected based on their recognizability in Scotland, Greece and The Netherlands. We collected image characteristics such as liking, perceived calories and/or perceived healthiness ratings from 449 adults and 191 children. The majority of the foods were recognized and liked at all sites. The differences in liking ratings, perceived calories and perceived healthiness between sites were minimal. Furthermore, perceived caloric content and healthiness ratings correlated strongly (r ≥ 0.8) with actual caloric content in both adults and children. The photographing protocol as well as the images and the data are freely available for research use on http://nutritionalneuroscience.eu/. By providing the research community with standardized images and the tools to create their own, comparability between studies will be improved and a head-start is made for a world-wide standardized food image database. PMID:26344127

  16. [Diagnostic workup and therapy of infectious diarrhea. Current standards].

    Science.gov (United States)

    Stallmach, A; Hagel, S; Lohse, A W

    2015-12-01

    Infectious diarrhea is very common; its severity ranges from uncomplicated, self-limiting courses to potentially life-threatening disease. A rapid diagnostic workup providing detailed information on the suspected pathogen should be performed only in patients at risk, analyzing one single stool sample for Salmonella, Shigella, Campylobacter, and Norovirus. In the presence of risk factors, such as a history of antibiotic exposure within the last 3 months, testing for Clostridium difficile should be performed. Immunocompetent patients do not require specific antibiotic therapy. Exceptions exist in patients with severe comorbidities, immunodeficiency, fever/SIRS, and in patients with Shigella or C. difficile infection. Empirical antibiotic treatment should be considered in patients with fever and/or bloody diarrhea and in patients at risk. In patients with traveler's diarrhea, microbiological diagnosis is required only in patients with fever, bloody diarrhea, prolonged course of disease (more than 5 days), severe clinical course with hypotension or dehydration, and during outbreaks. In these patients one single fecal sample should be collected for stool cultures of Campylobacter, Shigella, and Salmonella, as well as microscopic examination for amoebiasis and Giardiasis. The main therapeutic measure for infectious diarrhea is sufficient oral rehydration. As in community-acquired diarrhea, azithromycin or ciprofloxacin are recommended-taking into account local antimicrobial resistance in the country of travel and possible side effects. PMID:26573083

  17. Quality and standards in electronics

    CERN Document Server

    Tricker, Ray

    1997-01-01

    A manufacturer or supplier of electronic equipment or components needs to know the precise requirements for component certification and quality conformance to meet the demands of the customer. This book ensures that the professional is aware of all the UK, European and International necessities, knows the current status of these regulations and standards, and where to obtain them.

  18. Standardized Testing and School Accountability

    Science.gov (United States)

    Wiliam, Dylan

    2010-01-01

    This article explores the use of standardized tests to hold schools accountable. The history of testing for accountability is reviewed, and it is shown that currently between-school differences account for less than 10% of the variance in student scores, in part because the progress of individuals is small compared to the spread of achievement…

  19. Standardization in optical coating characterisation

    Institute of Scientific and Technical Information of China (English)

    D.Ristau

    2005-01-01

    In the rapid development course of laser technology and modern optics, optical metrology continuously gains importance for the quality management in the industrial production environment and also for research in optical coatings. Besides absorption and scatter losses, the spectral characteristics and laser induced damage thresholds are considered as common quality factors for coated optical components and often define the optimization targets for new products and applications. Also, these quality parameters are the basis for the comparison of commercial optics and can be found in the product catalogues of most manufacturers of optical components. As a consequence, standardization of characterisation procedures for these fundamental properties evolved to a crucial point for the optics industry. During the last decade, adapted standard measurement techniques have been elaborated and discussed by representatives from many industrial companies and research institutes within working groups of the International Organisation for Standardization (ISO). In this contribution, the current state of standardized characterisation techniques for optical coatings is summarised. Selected standards for the measurement of absorption (ISO 11551), scattering (ISO 13696) and laser induced damage thresholds (ISO 11254, Parts 1 and 2) will be described and discussed in view of their applicability and reproducibility. The report will be concluded by an outlook on the current projects and future tasks of standardization in optics characterisation.

  20. Can bivalve veligers escape feeding currents of adult bivalves?

    NARCIS (Netherlands)

    Troost, K.; Veldhuizen, R.; Stamhuis, E.J.; Wolff, W.J.

    2008-01-01

    While the stock of introduced Pacific oysters (Crassostrea gigas) increased in the Oosterschelde estuary (SW Netherlands), so did the filtration pressure of all bivalve species together. In the same period, stocks of native bivalves declined slightly. The expansion of Pacific oysters in Dutch estuar

  1. Strength Training. Rationale for Current Guidelines for Adult Fitness Programs.

    Science.gov (United States)

    Feigenbaum, Matthew S.; Pollock, Michael L.

    1997-01-01

    Strength training is an effective method of developing musculoskeletal strength and is often prescribed for fitness, health, and for prevention and rehabilitation of orthopedic injuries. This paper describes and presents a rationale for the population-specific strength training guidelines established by major health organizations. (SM)

  2. Treatment of adult ADHD: Is current knowledge useful to clinicians?

    OpenAIRE

    Torgersen, Terje

    2008-01-01

    Terje Torgersen1,2, Bjørn Gjervan1,3, Kirsten Rasmussen31Department of Psychiatry, Sykehuset Levanger, Helse Nord-Troendelag HF, Levanger, Norway; 2Faculty of Medicine and 3Department of Psychology, Norwegian University of Science and Technology, Trondheim, NorwayAbstract: Psychostimulant drugs have for decades been considered the cornerstone of ADHD treatment. Non-stimulant drugs have also been reported successful. However, many controlled studies exclude patients with comorbiditi...

  3. The Current in a Wire

    Science.gov (United States)

    Thompson, Keith

    2009-01-01

    This little problem arose because I was frustrated with the standard electromagnetism texts, which show the magnetic field due to a current-bearing wire outside the wire [proportional to] 1/r and inside [proportional to] r. However, they never point out that the moving electrons must be influenced by the magnetic field created by the other moving…

  4. Standards for Standardized Logistic Regression Coefficients

    Science.gov (United States)

    Menard, Scott

    2011-01-01

    Standardized coefficients in logistic regression analysis have the same utility as standardized coefficients in linear regression analysis. Although there has been no consensus on the best way to construct standardized logistic regression coefficients, there is now sufficient evidence to suggest a single best approach to the construction of a…

  5. Necessity of Having Philosophy of Adult Education as an Interdisciplinary Field at a Graduate Level

    OpenAIRE

    A. Zandvanian

    2010-01-01

    The aim of this paper is to introduce Philosophy of Adult Education as an interdisciplinary field at a graduate level. Currently, the field of Philosophy of Education and Adult Education are offered as two independent fields at some universities .This paper strives to create a link between Adult Education and Philosophy of Education. In this paper, a hundredyear history of philosophical studies in adult education has been reviewed. Although the major topics in Philosophy of Adult Education...

  6. Status of conversion of DOE standards to non-Government standards

    Energy Technology Data Exchange (ETDEWEB)

    Moseley, H.L.

    1992-07-01

    One major goal of the DOE Technical Standards Program is to convert existing DOE standards into non-Government standards (NGS's) where possible. This means that a DOE standard may form the basis for a standards-writing committee to produce a standard in the same subject area using the non-Government standards consensus process. This report is a summary of the activities that have evolved to effect conversion of DOE standards to NGSs, and the status of current conversion activities. In some cases, all requirements in a DOE standard will not be incorporated into the published non-Government standard because these requirements may be considered too restrictive or too specific for broader application by private industry. If requirements in a DOE standard are not incorporated in a non-Government standard and the requirements are considered necessary for DOE program applications, the DOE standard will be revised and issued as a supplement to the non-Government standard. The DOE standard will contain only those necessary requirements not reflected by the non-Government standard. Therefore, while complete conversion of DOE standards may not always be realized, the Department's technical standards policy as stated in Order 1300.2A has been fully supported in attempting to make maximum use of the non-Government standard.

  7. Status of conversion of DOE standards to non-Government standards

    Energy Technology Data Exchange (ETDEWEB)

    Moseley, H.L.

    1992-07-01

    One major goal of the DOE Technical Standards Program is to convert existing DOE standards into non-Government standards (NGS`s) where possible. This means that a DOE standard may form the basis for a standards-writing committee to produce a standard in the same subject area using the non-Government standards consensus process. This report is a summary of the activities that have evolved to effect conversion of DOE standards to NGSs, and the status of current conversion activities. In some cases, all requirements in a DOE standard will not be incorporated into the published non-Government standard because these requirements may be considered too restrictive or too specific for broader application by private industry. If requirements in a DOE standard are not incorporated in a non-Government standard and the requirements are considered necessary for DOE program applications, the DOE standard will be revised and issued as a supplement to the non-Government standard. The DOE standard will contain only those necessary requirements not reflected by the non-Government standard. Therefore, while complete conversion of DOE standards may not always be realized, the Department`s technical standards policy as stated in Order 1300.2A has been fully supported in attempting to make maximum use of the non-Government standard.

  8. Adult attachment styles

    Directory of Open Access Journals (Sweden)

    Maša Žvelc

    2007-01-01

    Full Text Available Theory of attachment primarily described early relationships between a child and his caretakers. In the last twenty years there is a growing interest in adult attachment research. Theories and research findings of adult attachment stem from two different methodological approaches. The first approach measures adult attachment through Adult Attachment Interview (AAI; Main, 1991 where the attachment is assessed through the narratives of adult people of their early child experiences with their primary caretakers. The second approach measures adult attachment with the help of self-evaluative questionnaires, developed by (a Hazan and Shaver (1987 who started this approach in the field of personality and social psychology, and (b Bartholomew and Horowitz (1991. Research shows that there is significant correlation between early and adult attachment style. Attachment styles are passed from generation to generation. Basic adult attachment styles are: securely attached, preoccupied, fearful-avoidant, dismissing-avoidant and disorganized. Previous research using Barholomew and Horowitz (1991 Relationship Questionnaire on 176 Slovenian students showed that 48% students are securely attached, 29% are fearful-avoidant, 10% are dismissing-avoidant, and 13% have preoccupied attachment style. Theory of attachment is very useful for understanding the behavior and subjective experiences of children and adults. It is applicable to different contexts (psychotherapy, counseling, education .... The paper proposes further research focused on integration of adult attachment styles and types of object relations measured by Test of object relations (Žvelc, 1998 and Pictorial test of Separation and Individuation (Žvelc, 2003.

  9. 77 FR 37923 - Comment Request for Information Collection for the Workforce Investment Act (WIA) Adult and...

    Science.gov (United States)

    2012-06-25

    ... Investment Act (WIA) Adult and Dislocated Worker Programs Gold Standard Evaluation (WIA Evaluation); New...--adults and dislocated workers in this group can receive any WIA service for which they are eligible; (2) the core-and-intensive group--adults and dislocated workers in this group can receive any...

  10. Effects of an aerobic exercise program on driving performance in adults with cardiovascular disease.

    Science.gov (United States)

    Gaudet, Jeffrey; Mekary, Saïd; Bélanger, Mathieu; Johnson, Michel

    2016-06-01

    Cardiovascular disease (CVD) has been linked to decreases in driving performance and an increased crash risk. Regular exercise has been linked to improved driving performance among healthy adults. The aim of the current study was to investigate the relationship between a 12-week cardiac rehabilitation (CR) program and driving performance among individuals with CVD. Twenty-five individuals, including 12 cardiac adults and 13 healthy adults, took part in this study. Simulated driving performance was assessed using a standardized demerit-based scoring system at 0 and 12 weeks. Cardiac participants completed a 12-week CR program between evaluations. At baseline, cardiac participants had a higher number of demerit points than healthy adults (120.9±38.1 vs. 94.7±28.3, P=0.04). At follow-up, there was an improvement in both groups' driving evaluations, but the improvement was greater among the cardiac group such that there was no longer a difference in driving performance between both groups (94.6±30 vs. 86.9±34.8, P=0.51). Participation in an aerobic exercise-based CR program appears to lead to improvements in simulated driving performances of individuals with CVD. PMID:26756849

  11. APS beamline standard components handbook

    International Nuclear Information System (INIS)

    It is clear that most Advanced Photon Source (APS) Collaborative Access Team (CAT) members would like to concentrate on designing specialized equipment related to their scientific programs rather than on routine or standard beamline components. Thus, an effort is in progress at the APS to identify standard and modular components of APS beamlines. Identifying standard components is a nontrivial task because these components should support diverse beamline objectives. To assist with this effort, the APS has obtained advice and help from a Beamline Standardization and Modularization Committee consisting of experts in beamline design, construction, and operation. The staff of the Experimental Facilities Division identified various components thought to be standard items for beamlines, regardless of the specific scientific objective of a particular beamline. A generic beamline layout formed the basis for this identification. This layout is based on a double-crystal monochromator as the first optical element, with the possibility of other elements to follow. Pre-engineering designs were then made of the identified standard components. The Beamline Standardization and Modularization Committee has reviewed these designs and provided very useful input regarding the specifications of these components. We realize that there will be other configurations that may require special or modified components. This Handbook in its current version (1.1) contains descriptions, specifications, and pre-engineering design drawings of these standard components. In the future, the APS plans to add engineering drawings of identified standard beamline components. Use of standard components should result in major cost reductions for CATs in the areas of beamline design and construction

  12. Standard environmental test methods

    Energy Technology Data Exchange (ETDEWEB)

    Schafer, D R

    1983-12-01

    This guide to uniformity in testing is intended primarily as an aid to persons responsible for designing, developing, and performing environmental tests. It will also be of use to those concerned with production, evaluation, and quality control and assurance. Checklists for preparing the environmental testing portion of product specifications are included, as are copies of Process Standards covering the instrumentation, equipment, and methods for use in environmental testing of Sandia National Laboratories components. Techniques and equipment are constantly improving. This version of SC-4452 reflects current state-of-the-art and practice in environmental testing. Previously existing sections of the document have ben updated and new ones have been added, e.g., Transient Testing on Vibration Machines.

  13. Riparian forestry management and adult stream insects

    Directory of Open Access Journals (Sweden)

    R. A. Briers

    2004-01-01

    Full Text Available The impacts of coniferous plantation forestry on the biology of upland streams in the UK are firmly established. Whilst benthic communities have been well studied, very little research has considered the impacts of riparian forestry management on adult stream insects, yet the essentially terrestrial adult (reproductive phase may be important in determining the abundance and distribution of larval stages. Riparian vegetation has a potentially strong impact on survival and success of adult stages through alteration of microclimate, habitat structure and potential food sources, in addition to effects carried over from larval stages. Here, current riparian management strategies are analysed in the light of available information on the ecology of adult stream insects. On the whole, management practices appear to favour adult stream insects, although an increase in tree cover in riparian areas could be beneficial, by providing more favourable microclimatic conditions for adults. This conclusion is drawn based on rather limited information, and the need for further research into the effects of riparian forestry management on adult stream insects is highlighted. Keywords: microclimate, plantation, life history, riparian vegetation

  14. Provision of Transition Education and Referral Patterns from Pediatric Cardiology to Adult Cardiac Care.

    Science.gov (United States)

    Harbison, Anna L; Grady, Stafford; Chi, Kevin; Fernandes, Susan M

    2016-02-01

    ACC/AHA guidelines recommend a structured preparation for and transfer to adult-oriented cardiac care for adult survivors of pediatric onset heart disease (POHD). Given this, we sought to describe the transition and transfer practices for a cohort of young adults with POHD and to determine factors associated with successful transfer to adult-oriented cardiac care. We performed a single-center, retrospective chart review on patients ≥18 years of age, with POHD likely to require lifelong cardiac care, who were seen in outpatient pediatric cardiology (PC) between 2008 and 2011. Successful transfer was defined as the subsequent attendance at adult cardiology (AC) within 2 years of PC visit. We identified 118 patients who met study criteria. Mean age 22.4 ± 2.0 years, 59 % male, 64 % white and 40 % Hispanic. Mean transition education topics noted was 3.3 ± 1.8 out of 20 and covered the underlying cardiac disease (89 %), follow-up and current medications (56 %) and exercise limitations (34 %). Recommendations for follow-up were AC (57 %) and PC (33 %). Of those told to transfer to AC, 79 % successfully transferred. Characteristics of successful transfer included: prior cardiac surgery (p = 0.008), cardiac medication use (p = 0.006) and frequency of follow-up ≤1 year (p = 0.037). One-quarter of all subjects did not follow-up within at least 2 years. Despite published guidelines, transition education appears lacking and the approach to transfer to adult cardiac care is not consistent. Given the increased risk of morbidity and mortality in this patient population, standardization of transition education and transfer processes appear warranted. PMID:26385471

  15. Graphic arts standards update: 1996

    Science.gov (United States)

    McDowell, David Q.

    1996-03-01

    Color definition and data exchange continue to be dominant themes in both the US and international graphic arts standards activity. However, there is a growing understanding of the role that metrology and printing process definition play in helping define stable process conditions to which color characterization data can be related. Standards have already been published that define the requirements for color measurement and computation, scanner input characterization targets, four-color output characterization data sets, and graphic arts applications of densitometry. Work continues on standards relating to ink testing and ink color specifications. The numerical specifications of SWOP proof printing have been captured in ANSI standard CGATS.6-1995. Work has been completed, and Technical Report ANSI CGATS TR 001-1995 has been published, that relates the colorimetry of the printed sheet to the CMYK input for press proofing meeting SWOP and CGATS.6 specifications. Work is ongoing to provide similar data for other printing processes. Such color characterization data is key to the development of color profiles for standard printing conditions. Specifications for color profiles, to allow color definitions to be moved between color management systems, are being developed by the International Color Consortium. The existing graphic arts data exchange, process control, and color related standards are summarized and the current status of work in progress is reviewed. In addition, the interaction of the formal standards programs and other industry-driven specification activity is discussed.

  16. New Brachytherapy Standards Paradigm Shift

    International Nuclear Information System (INIS)

    The absorbed dose to water rate at short distances in water is the quantity of interest for dosimetry in radiotherapy, but no absorbed dose to water primary standards have been available to date for dosimetry of brachytherapy sources. Currently, the procedures to determine the absorbed dose imparted to the patient in brachytherapy treatments are based on measurements traceable to air kerma standards. These procedures are affected by an uncertainty that is larger than the limit recommended by the IAEA dosimetry protocol (IAEA TRS 398 (2000)). Based on this protocol, the goal for the uncertainty of the dose delivered to the target volume should be within 5% (at the level of one standard deviation) to assure the effectiveness of a radiotherapy treatment. The international protocols for the calibration of brachytherapy gamma ray sources are based on the reference air kerma rate or the air kerma strength. The absorbed dose to water, in water at the reference position around a brachytherapy source is then calculated by applying the formalism of the protocols based on a conversion constant, the dose rate constant Λ, specific for the characteristics and geometry of the brachytherapy source. The determination of this constant relies on Monte Carlo simulations and relative measurements performed with passive dosimeters, and therefore it is typically affected by large uncertainties, larger than 5% (at the level of one standard deviation). The conversion procedure needed for brachytherapy dosimetry is a source of additional uncertainty on the final value of the absorbed dose imparted to the patient. It is due to a lack of metrology standards that makes dosimetry of brachytherapy sources less accurate than dosimetry of external radiation beams produced by 60Co sources and accelerators currently used in external beam radiotherapy. This paper reviews the current developments of absorbed dose to water primary standards for brachytherapy and the rationale for the choice of the

  17. Anticoagulation in adults with congenital heart disease

    DEFF Research Database (Denmark)

    Jensen, A S; Idorn, L; Nørager, B;

    2015-01-01

    Adults with congenital heart disease are a growing population. One of the major challenges in the care of these patients is to prevent thromboembolic episodes. Despite relative young age and no typical cardiovascular risk factors, this cohort has a high prevalence of thrombotic events. It is....... Furthermore, there is a lack of scientific evidence regarding how to prevent thromboembolic events with anticoagulation in adults with congenital heart disease. The aim of this paper is to review the current literature pertaining to anticoagulation in adults with congenital heart disease and hence enable...... difficult to use treatment algorithms from the general adult population with acquired heart disease in this heterogeneous population due to special conditions such as myocardial scarring after previous surgery, atypical atrial flutter, prothrombotic conditions and the presence of interatrial shunts...

  18. XML Diagnostics Description Standard

    International Nuclear Information System (INIS)

    A standard for the self-description of fusion plasma diagnostics will be presented, based on the Extensible Markup Language (XML). The motivation is to maintain and organise the information on all the components of a laboratory experiment, from the hardware to the access security, to save time and money when problems arises. Since there is no existing standard to organise this kind of information, every Association stores and organises each experiment in different ways. This can lead to severe problems when the organisation schema is poorly documented or written in national languages. The exchange of scientists, researchers and engineers between laboratories is a common practice nowadays. Sometimes they have to install new diagnostics or to update existing ones and frequently they lose a great deal of time trying to understand the currently installed system. The most common problems are: no documentation available; the person who understands it has left; documentation written in the national language. Standardisation is the key to solving all the problems mentioned. From the commercial information on the diagnostic (component supplier; component price) to the hardware description (component specifications; drawings) to the operation of the equipment (finite state machines) through change control (who changed what and when) and internationalisation (information at least in the native language and in English), a common XML schema will be proposed. This paper will also discuss an extension of these ideas to the self-description of ITER plant systems, since the problems will be identical. (author)

  19. Eddy current inspection methodology

    International Nuclear Information System (INIS)

    World-wide operating experience with nuclear pressurized water reactors shows that most steam generators show evidence of major degradation phenomena. Laborelec has designed several automated inspection systems using eddy current (bobbin coil, pancake coils and rotating coil) and ultrasound techniques. The bobbin coil is mostly used as a fast and global detection method while dedicated sensors, like the rotating pancake coil, are applied for an improved defect characterization. Experience has demonstrated that significant advantages in accuracy, reliability and cost are intimately related to the automation process. In conclusion: The concept of a multipurpose inspection system satisfies the safety goal and the utility requirements for reliability, accuracy and lower costs. An optimum was reached by equipment modularity, computer control and integrated design of sensors and instrumentation. What previously required several man-weeks of work is now achieved within a few hours time. With a presently unparalleled field performance, Laborelec has set the basis of new industrial standards

  20. Vitalistic thinking in adults.

    Science.gov (United States)

    Wilson, Stuart

    2013-11-01

    Vitalistic thinking has traditionally been associated with reasoning about biological phenomena. The current research aimed to investigate a broader range of vitalistic thinking than previously studied. Esoteric notions of 'energy' are frequently used by individuals when making causal attributions for strange occurrences, and previous literature has linked such thinking with paranormal, magical, and superstitious beliefs. Two experiments are described that aim to investigate whether adults are vitalistic when asked to make causal judgments, and whether this can be predicted by thinking styles and prior paranormal belief. Experiment 1 asked participants to rate three causal options (one of which was vitalistic) for six vignettes. Scores on one dimension of paranormal belief (New Age Philosophy) and analytical thinking significantly predicted vitalism, but scores on intuitive thinking and Traditional Paranormal Beliefs did not. Experiment 2 extended the findings by asking participants to generate their own causal responses. Again, paranormal belief was found to be the best predictor of vitalism, but this time Traditional Paranormal Beliefs were associated with vitalistic responses whilst both intuitive and analytical thinking were unable to significantly predict classification. Results challenge previous findings, suggesting that vitalistic thinking may operate differently when applied to everyday causal reasoning. PMID:24094281

  1. Strokes in young adults: epidemiology and prevention

    Directory of Open Access Journals (Sweden)

    Smajlović D

    2015-02-01

    Full Text Available Dževdet Smajlović Department of Neurology, University Clinical Centre Tuzla, School of Medicine, University of Tuzla, Bosnia and Herzegovina Abstract: Strokes in young adults are reported as being uncommon, comprising 10%–15% of all stroke patients. However, compared with stroke in older adults, stroke in the young has a disproportionately large economic impact by leaving victims disabled before their most productive years. Recent publications report an increased incidence of stroke in young adults. This is important given the fact that younger stroke patients have a clearly increased risk of death compared with the general population. The prevalence of standard modifiable vascular risk factors in young stroke patients is different from that in older patients. Modifiable risk factors for stroke, such as dyslipidemia, smoking, and hypertension, are highly prevalent in the young stroke population, with no significant difference in geographic, climatic, nutritional, lifestyle, or genetic diversity. The list of potential stroke etiologies among young adults is extensive. Strokes of undetermined and of other determined etiology are the most common types among young patients according to TOAST (Trial of Org 10172 in Acute Stroke Treatment criteria. Prevention is the primary treatment strategy aimed at reducing morbidity and mortality related to stroke. Therefore, primary prevention is very important with regard to stroke in young adults, and aggressive treatment of risk factors for stroke, such as hypertension, smoking, and dyslipidemia, is essential. The best form of secondary stroke prevention is directed toward stroke etiology as well as treatment of additional risk factors. However, there is a lack of specific recommendations and guidelines for stroke management in young adults. In conclusion, strokes in young adults are a major public health problem and further research, with standardized methodology, is needed in order to give us more

  2. Adult congenital heart disease

    OpenAIRE

    Morphet, John AM

    2006-01-01

    One million people over the age of 20 suffer from congenital heart disease in the United States. These adult patients can slip through the cracks of our medical system; many are too old to be cared for in most pediatric institutions by pediatric cardiologists and, unfortunately, most adult cardiologists are not trained in congenital heart disease. Therefore, it is important to identify the common lesions in adult congenital heart disease and how they should be managed. Acyanotic congenital he...

  3. Culture And Adult Immigrants

    OpenAIRE

    Andersen, Tamar Barbara; Fogde, Anne-Sofie; Rasmussen, Ditte Ninna; Uski, Juha Janne Olavi

    2005-01-01

    "Culture and adult immigrants" is a project about integration of adult immigrants into the Danish society. It is based on an integration theory by Charlotte Hamburger and a culture theory by Thomas Hylland Eriksen and Torunn Arntsen Sørheim. The two theories conclude in a joined analysis of language school material from the language centre of Roskilde, in search for an answer to the question if and how the Danish language education supports the integration of adult immigrants into the D...

  4. Proposed Josephson voltage standard

    Science.gov (United States)

    Chang, C. C.; Holderman, L. B.; Toots, J.

    1980-01-01

    Relatively-simple microwave integrated circuit comprising two resonators linked by Josephson junction could be set up to generate standard Josephson volt in any industrial laboratory. Standard cells and electronic equipment could be readily compared and calibrated to this standard.

  5. Standards help enterprises

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    @@ Standardization in modern times began from the Industrial Revolution. Various industrial sectors, for which about 300 standardization technical commissions have been established, make up the key fields of China's standardization.

  6. Standardization in Causal Analysis

    OpenAIRE

    Jae-On Kim; G. Donald Ferree Jr.

    1981-01-01

    In comparative study, it is argued that (1) the standardization of variables and scales should be separated from the habitual use of standardized coefficients; (2) the use of standardized coefficients implies standardizing every variable using group specific standards, and, therefore, it is not appropriate even if some variables have group specific metrics or some variables do not possess commonly accepted metrics; and (3) the explicit standardization of some or all variables can be fruitfull...

  7. Standards in education

    OpenAIRE

    Darko Zupanc

    2005-01-01

    Modern educational systems are based on standards. Systems in countries all over the world differ and have different tradition, so different terms are used for similar concepts. In education, standards should have a similar role as in physics, where they are empirical and measurable. Two types of standards can be defined: content or curriculum standards and performance standards, with the latter being essential. Setting educational goals or content standards is the first step in the construct...

  8. Medications and Older Adults

    Science.gov (United States)

    ... older adults and often require the use of antihistamines. Antihistamines are divided into two classes: first generation antihistamines and second generation antihistamines. First generation antihistamines, while ...

  9. An investigation into the use of digital technology in adult education - how does it affect roles in adult education?

    OpenAIRE

    Murphy, Henrietta Clare

    2013-01-01

    non-peer-reviewed Adult education and further training in Ire land is currently undergoing reform. The VEC structure is now abolished and it has been rcplaced by Education and Training Boards. Meanwhile digital technology is also being integrated into adult education and bringing about changes of its own. This case study aimed primarily to examinc how thc use of digital tecliiJgy can impact on the roles of those involved ill adult education. In particular, thc focus of the ...

  10. Creating standards: Creating illusions?

    DEFF Research Database (Denmark)

    Linneberg, Mai Skjøtt

    This paper explores the relationship between written standards and the phenomena under standardisation. In this paper written standards are looked upon as representations of practice phenomena, and the paper argues that standards can represent these to a smaller or larger extent. Therefore, some...... written standards may open up for the creation of illusions. These are created when written standards' content is not in accordance with the perception standard adopters and standard users have of the specific practice phenomenon's content. This general theoretical argument is exemplified by the specific...... case of organic agricultural standards....

  11. What is "Standard" About the Standard Deviation

    OpenAIRE

    Newberger, Florence; Safer, Alan M.; Watson, Saleem

    2010-01-01

    The choice of the formula for standard deviation is explained in elementary statistics textbooks in various ways. We give an explanation for this formula by representing the data as a vector in $\\mathbb R^n$ and considering its distance from a central tendency vector. In this setting the "standard" formula represents a shortest distance in the standard metric. We also show that different metrics lead to different measures of central tendency.

  12. A new standard pulsar magnetosphere

    International Nuclear Information System (INIS)

    In view of recent efforts to probe the physical conditions in the pulsar current sheet, we revisit the standard solution that describes the main elements of the ideal force-free pulsar magnetosphere. The simple physical requirement that the electric current contained in the current layer consists of the local electric charge moving outward at close to the speed of light yields a new solution for the pulsar magnetosphere everywhere that is ideal force-free except in the current layer. The main elements of the new solution are as follows: (1) the pulsar spindown rate of the aligned rotator is 23% larger than that of the orthogonal vacuum rotator; (2) only 60% of the magnetic flux that crosses the light cylinder opens up to infinity; (3) the electric current closes along the other 40%, which gradually converges to the equator; (4) this transfers 40% of the total pulsar spindown energy flux in the equatorial current sheet, which is then dissipated in the acceleration of particles and in high-energy electromagnetic radiation; and (5) there is no separatrix current layer. Our solution is a minimum free-parameter solution in that the equatorial current layer is electrostatically supported against collapse and thus does not require a thermal particle population. In this respect, it is one more step toward the development of a new standard solution. We discuss the implications for intermittent pulsars and long-duration gamma-ray bursts. We conclude that the physical conditions in the equatorial current layer determine the global structure of the pulsar magnetosphere.

  13. A New Standard Pulsar Magnetosphere

    Science.gov (United States)

    Contopoulos, Ioannis; Kalapotharakos, Constantinos; Kazanas, Demosthenes

    2014-01-01

    In view of recent efforts to probe the physical conditions in the pulsar current sheet, we revisit the standard solution that describes the main elements of the ideal force-free pulsar magnetosphere. The simple physical requirement that the electric current contained in the current layer consists of the local electric charge moving outward at close to the speed of light yields a new solution for the pulsar magnetosphere everywhere that is ideal force-free except in the current layer. The main elements of the new solution are as follows: (1) the pulsar spindown rate of the aligned rotator is 23% larger than that of the orthogonal vacuum rotator; (2) only 60% of the magnetic flux that crosses the light cylinder opens up to infinity; (3) the electric current closes along the other 40%, which gradually converges to the equator; (4) this transfers 40% of the total pulsar spindown energy flux in the equatorial current sheet, which is then dissipated in the acceleration of particles and in high-energy electromagnetic radiation; and (5) there is no separatrix current layer. Our solution is a minimum free-parameter solution in that the equatorial current layer is electrostatically supported against collapse and thus does not require a thermal particle population. In this respect, it is one more step toward the development of a new standard solution. We discuss the implications for intermittent pulsars and long-duration gamma-ray bursts. We conclude that the physical conditions in the equatorial current layer determine the global structure of the pulsar magnetosphere.

  14. Current Trends in Higher Education Technology: Simulation

    Science.gov (United States)

    Damewood, Andrea M.

    2016-01-01

    This paper is focused on how technology in use changes over time, and the current trend of simulation technology as a supported classroom technology. Simulation-based training as a learning tool is discussed within the context of adult learning theories, as is the technology used and how today's higher education technology administrators support…

  15. Ready or Not? Criteria for Marriage Readiness among Emerging Adults

    Science.gov (United States)

    Carroll, Jason S.; Badger, Sarah; Willoughby, Brian J.; Nelson, Larry J.; Madsen, Stephanie D.; Barry, Carolyn McNamara

    2009-01-01

    This study examined emerging adults' criteria for marriage readiness and explored how these criteria are associated with their current attitudes and behaviors. This article establishes the psychometric value of the Criteria for Marriage Readiness Questionnaire and reports on a study of 788 emerging adults recruited from five college sites across…

  16. FACTOR STRUCTURE OF DSM-IV SYMPTOMS IN ADULTS

    Science.gov (United States)

    Objective: In up to 50% of clinic-referred samples of children, ADHD symptoms persist into adulthood,1-3 with the prevalence of adult ADHD currently estimated at 4.4%4. Similar to the pervasive impairments experienced by children with ADHD, adults with ADHD are less likely to com...

  17. The Nature of Subjective Cognitive Complaints of Older Adults

    Science.gov (United States)

    Newson, Rachel S.; Kemps, Eva B.

    2006-01-01

    The current study investigated the nature of subjective cognitive complaints of older adults in relation to a broad array of individual cognitive functions known to decline with age. A 60-item questionnaire was developed to examine: (1) whether older adults experience problems with these cognitive functions (problems with cognition); (2) the…

  18. Counseling Adult Sex Offenders: Unique Challenges and Treatment Paradigms.

    Science.gov (United States)

    Priest, Ronnie; Smith, Annalee

    1992-01-01

    Reviews current definitions and research literature related to characteristics of adults who sexually victimize children. Presents discussion of pedophilia as a sexual deviation. Examines treatment issues that may confront counselors engaged in treating adults who sexually victimize children and discusses implications for practitioners. (Author/NB)

  19. Adult Attachment and Longterm Effects in Survivors of Incest.

    Science.gov (United States)

    Alexander, Pamela C.; Anderson, Catherine L.; Brand, Bethany; Schaeffer, Cindy M.; Grelling, Barbara Z.; Kretz, Lisa

    1998-01-01

    Ninety-two adult female incest survivors were interviewed and completed measures of current functioning. Hierarchical regression analyses suggested that adult attachment behavior was significantly associated with personality structure, depression, and distress; and abuse severity was associated with posttraumatic stress disorder symptoms and…

  20. Adult Neurogenesis and Psychiatric Disorders.

    Science.gov (United States)

    Kang, Eunchai; Wen, Zhexing; Song, Hongjun; Christian, Kimberly M; Ming, Guo-Li

    2016-01-01

    Psychiatric disorders continue to be among the most challenging disorders to diagnose and treat because there is no single genetic or anatomical locus that is causative for the disease. Current treatments are often blunt tools used to ameliorate the most severe symptoms, at the risk of disrupting functional neural systems. There is a critical need to develop new therapeutic strategies that can target circumscribed functional or anatomical domains of pathology. Adult hippocampal neurogenesis may be one such domain. Here, we review the evidence suggesting that adult hippocampal neurogenesis plays a role in emotional regulation and forms of learning and memory that include temporal and spatial memory encoding and context discrimination, and that its dysregulation is associated with psychiatric disorders, such as affective disorders, schizophrenia, and drug addiction. Further, adult neurogenesis has proven to be an effective model to investigate basic processes of neuronal development and converging evidence suggests that aberrant neural development may be an etiological factor, even in late-onset diseases. Constitutive neurogenesis in the hippocampus of the mature brain reflects large-scale plasticity unique to this region and could be a potential hub for modulation of a subset of cognitive and affective behaviors that are affected by multiple psychiatric disorders. PMID:26801682

  1. Taking Current Antiretroviral Drugs

    Science.gov (United States)

    ... INHIBITORS INTEGRASE INHIBITORS 1. NUCLEOSIDE AND NUCLEOTIDE ANALOG REVERSE TRANSCRIPTASE INHIBITORS (NUKES) DRUG DAILY PILLS (ADULTS) HOW TO TAKE & ... Don't combine with d4T. 2. NON-NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS** (NNRTIs or NON-NUKES) DRUG DAILY PILLS (Adults)* ...

  2. XI. Management of paediatric and adult non-Hodgkin lymphoma: what lessons can each teach the other?

    Science.gov (United States)

    Burkhardt, Birgit; Lenz, Georg

    2015-06-01

    Is there anything that we can learn from each other regarding paediatric and adult non-Hodgkin Lymphoma (NHL) management? Do we treat the same patients? Are there differences in lymphoma biology in the different age groups? Are the procedures of decision making and the infrastructure comparable? Is the weighing of toxicity and outcome aspects in the benefit and risk assessments prior to treatment decisions comparable? Interestingly, the proportional distribution of the NHL subtypes and the spectrum of NHL occurring in children and adolescents differs significantly from that in adults. This observation might motivate biological studies aiming to elucidate the pathomechanisms of lymphomagenesis. Concerning NHL diagnosis and staging, the comparison of outcome data reported for paediatric and adult patient series is often impaired by the use of different staging systems. However, the impact of reference laboratories supporting correct subtyping and the advantages of population-based patient recruitment are experiences that might be transferable between paediatric and adult oncologists. Interestingly, the process of implementing new drugs into current treatment strategies and making these drugs available to patients varies substantially across patient's age groups. The far lower absolute number of patients, especially of relapsed patients, and the favorable outcome with current standard treatment may contribute to the marked differences in the kinetic of implementing new compounds comparing adult with paediatric NHL patients. Also, the basis for the conduction of cooperative clinical trials with pharmaceutical companies needs to be strengthened in paediatric clinical trial groups. In conclusion, both paediatric and adult oncologists benefit from the interdisciplinary discussion with each other, not only concerning results and experiences in clinical trials but also with respect to critical aspects of infrastructure. PMID:26062057

  3. White matter structure changes as adults learn a second language.

    Science.gov (United States)

    Schlegel, Alexander A; Rudelson, Justin J; Tse, Peter U

    2012-08-01

    Traditional models hold that the plastic reorganization of brain structures occurs mainly during childhood and adolescence, leaving adults with limited means to learn new knowledge and skills. Research within the last decade has begun to overturn this belief, documenting changes in the brain's gray and white matter as healthy adults learn simple motor and cognitive skills [Lövdén, M., Bodammer, N. C., Kühn, S., Kaufmann, J., Schütze, H., Tempelmann, C., et al. Experience-dependent plasticity of white-matter microstructure extends into old age. Neuropsychologia, 48, 3878-3883, 2010; Taubert, M., Draganski, B., Anwander, A., Müller, K., Horstmann, A., Villringer, A., et al. Dynamic properties of human brain structure: Learning-related changes in cortical areas and associated fiber connections. The Journal of Neuroscience, 30, 11670-11677, 2010; Scholz, J., Klein, M. C., Behrens, T. E. J., & Johansen-Berg, H. Training induces changes in white-matter architecture. Nature Neuroscience, 12, 1370-1371, 2009; Draganski, B., Gaser, C., Busch, V., Schuirer, G., Bogdahn, U., & May, A. Changes in grey matter induced by training. Nature, 427, 311-312, 2004]. Although the significance of these changes is not fully understood, they reveal a brain that remains plastic well beyond early developmental periods. Here we investigate the role of adult structural plasticity in the complex, long-term learning process of foreign language acquisition. We collected monthly diffusion tensor imaging scans of 11 English speakers who took a 9-month intensive course in written and spoken Modern Standard Chinese as well as from 16 control participants who did not study a language. We show that white matter reorganizes progressively across multiple sites as adults study a new language. Language learners exhibited progressive changes in white matter tracts associated with traditional left hemisphere language areas and their right hemisphere analogs. Surprisingly, the most significant changes

  4. Charm current-current correlators in twisted mass lattice QCD

    International Nuclear Information System (INIS)

    The charm quark mass and the strong coupling constant are two of the fundamental parameters of the Standard Model and the precision of their determination has been continuously enhanced by higher order perturbative QCD calculations combined with more precise experimental data from e+-e-scattering as well as non-perturbative lattice calculations. As opposed to using experimental data to include non-perturbative effects, lattice QCD is not confined to the vector current correlator alone but additionally allows for an extension to the axial vector, scalar and pseudoscalar current correlators giving rise to a larger number of operators to extract the desired parameters from. We study the moments of the diverse charm current-current correlators in the framework of twisted mass lattice QCD with two light dynamical quarks. By matching lattice QCD results to continuum perturbation theory the strong coupling constant and the charm quark mass are extracted and compared to QCD sum rule and previous lattice calculations.

  5. Lectures on Physics Beyond the Standard Model

    OpenAIRE

    Gripaios, Ben

    2015-01-01

    These four lectures, given at the British Universities Summer School in Theoretical Elementary Particle Physics (BUSSTEPP), held in 2014 in Southampton, are a brief introduction to a selection of current topics in physics Beyond the Standard Model.

  6. Estimation of sex from the upper limb measurements of Sudanese adults.

    Science.gov (United States)

    Ahmed, Altayeb Abdalla

    2013-11-01

    Sex estimation is the first biological attribute needed for personal identification from mutilated and amputated limbs or body parts in medical-legal autopsies. Populations have different sizes and proportions that affect the anthropometric assessment of sex. Relatively few published works assess the accuracy of sex estimation from soft tissue measurements of upper limb parts, except for the hand and its components, but these studies involve a limited range of global populations. The current study aimed to assess the degree of sexual dimorphism in upper limb measurements and the accuracy of using these measurements for sex estimation in a contemporary adult Sudanese population. The upper arm length, ulnar length, wrist breadth, hand length, and hand breadth of 240 right-handed Sudanese subjects (120 males and 120 females) aged between 25 and 30 years were measured by international anthropometric standards. Demarking points, sexual dimorphism indices and discriminant functions were developed from 200 subjects (100 males and 100 females) who composed the study group. All variables were sexually dimorphic. The ulnar length, wrist breadth and hand breadth significantly contributed to sex estimation. Forearm dimensions showed a higher accuracy for sex estimation than hand dimensions. Cross-validated sex classification accuracy ranged between 78.5% and 89.5%. The reliability of these standards was assessed in a test sample of 20 males and 20 females, and the results showed accuracy between 77.5% and 90%. This study provides new forensic standards for sex estimation from upper limb measurements of Sudanese adults. PMID:24237816

  7. Reliability of quantitative echocardiography in adult sheep and goats

    Directory of Open Access Journals (Sweden)

    Hallowell Gayle D

    2012-09-01

    Full Text Available Abstract Background Echocardiography is a non-invasive method for assessment of the ovine and caprine heart. Complete reference ranges for cardiac dimensions and time indices for both species are not currently available and reliability of these measurements has not been evaluated. The objectives for this study are to report reliability, normal cardiac dimensions and time indices in a large group of adult sheep and goats. Fifty-one adult sheep and forty adult goats were recruited. Full echocardiographic examinations were performed in the standing unsedated animal. All animals underwent echocardiography four times in a 72-hour period. Echocardiography was performed three times by one author and once by another. Images were stored and measured offline. Technique and measurement repeatability and reproducibility and any differences due to animal or day were evaluated. Reference ranges (mean ± 2 standard deviations were calculated for both species. Results Majority of the images obtained were of good to excellent quality. Image acquisition was straightforward with 5.4% of animals demonstrating a small scanning window. Reliability was excellent for majority of dimensions and time indices. There was less variation in repeatability when compared with reproducibility and differences were greater for technique than for measurements. Dimensions that were less reliable included those for right ventricular diameter and left ventricular free wall. There were many differences in cardiac dimensions between sheep and goats. Conclusions This study has demonstrated that specific reference ranges are required for these two species. Repeatability and reproducibility were excellent for the majority of cardiac dimensions and time indices suggesting that this technique is reliable and valuable for examination of clinical cases over time and for longitudinal research studies.

  8. Standardization in digital pathology: Supplement 145 of the DICOM standards

    Directory of Open Access Journals (Sweden)

    Rajendra Singh

    2011-01-01

    Full Text Available As digital slides need a lot of storage space, lack of a singular method to acquire and store these large, two-dimensional images has been a major stumbling block in the universal acceptance of this technology. The DICOMS Standard Committee Working Group 26 has put in a tremendous effort to standardize storage methods so that they are more in line with currently available PACS in most hospitals for storage of radiology images. A recent press release (Supplement 145 of these standards was hailed by one and all involved in the field of digital pathology as it will make it easier for hospitals to integrate digital pathology into their already established systems without adding too much overhead costs. Besides, it will enable different vendors developing the scanners to upgrade their products to storage systems that are common across all systems.

  9. Adult Education Regional Planning

    Science.gov (United States)

    California Community Colleges, Chancellor's Office, 2015

    2015-01-01

    For more than one hundred and fifty years, until 2008, California was an undisputed national leader in its commitment to adult education. The state's investment in adult learners topped $750 million, a sum greater than the combined total of every other state in the nation. However, for the past several years recession and fiscal crisis have left…

  10. Adult learning in modernity

    DEFF Research Database (Denmark)

    Rasmussen, Palle

    2007-01-01

    The paper discusses the conditions for the growth of adult education in modern societies. It is argued that in modern adult life individual biographical reflection plays an increasing role, not only for educational and occupational choice but also in the process of identity formation and emotional...

  11. Toward Transpersonal Adult Development

    Science.gov (United States)

    Boucouvalas, Marcie

    2016-01-01

    As a foundation for discussing transpersonal adult development, the author traces her trajectory, involvement in, and contribution to the modern transpersonal movement and her introduction of it to the adult learning literature, beginning during the early 1980s. Highlighted are the transpersonal domain and a differentiation between transpersonal…

  12. Authenticity in Adult Learning

    Science.gov (United States)

    Ashton, Sam

    2010-01-01

    This paper is concerned with the relationship between authenticity and adult learning and prompted by some studies in which adult "authentic learning" is a central concept. The implication revealed by them is that real-worldness of learning contexts, learning content and learning tasks is perceived as conferring authenticity on learning. Here,…

  13. Adult Learning and Education

    Science.gov (United States)

    Rubenson, Kjell, Ed.

    2011-01-01

    As individuals and societies try to respond to fundamental economic and social transformation, the field of adult learning and education is rapidly getting increased attention and new topics for research on adult learning have emerged. This collection of articles from the International Encyclopedia of Education 3e offers practitioners and…

  14. Adults with pertussis

    OpenAIRE

    MacLean, D. W.

    1982-01-01

    Eighty adults were diagnosed in one general practice as having infection due to Bordetella pertussis, type 1.3, during a period of 30 months. Their clinical presentation and progress is recorded. A plea is made for attention to be paid to this infection in adults.

  15. Adult Education in Finland

    Science.gov (United States)

    Szekely, Radu

    2006-01-01

    Ever since the first ideas of national independence appeared in Finland, adult education has played an essential role in shaping the destiny of the Finns. With a history of almost 130 years, during which it has continuously increased in quality and quantity, the Finnish adult education system has ensured that Finland stays among the most…

  16. Adult and lifelong education

    DEFF Research Database (Denmark)

    Milana, Marcella; Holford, John; Mohorčič Špolar, Vida

    2014-01-01

    The contributions published in this special issue of Globalisation, Societies and Education draw from an international conference “Trans-nationalization of Educational Policy Making: Implications for Adult and Lifelong Learning”, held in Nottingham on 10-12 February 2012. The conference...... and lifelong education. Accordingly, the focus was on on-going analysis and reflections on the implications for adult and lifelong education policies of globalization, and the trans-nationalization of decision-making that comes with it. This special issue brings together a first selection of papers presented...... was organised by the Research Network on Policy Studies on Adult Education, established under the auspices of the European Society for the Research on the Education of Adults (ESREA). The aim of the conference was to explore how globalisation affects agency and policy processes in the area of adult and lifelong...

  17. Standardization and the European Standards Organisations

    Directory of Open Access Journals (Sweden)

    Marta Orviska

    2014-01-01

    Full Text Available Standardization is a relatively neglected aspect of the EU regulatory process and yet it is fundamental to that process and arguably has recently been the key vehicle in making the single market an economic reality. Yet the key standardization bodies in the EU, the ESOs, are scarcely known to the public and seldom discussed in the literature. In this article we redress this imbalance, arguing that standardization and integration are closely related concepts. We also argue that the ESOs have developed a degree of autonomy in expanding the boundaries of standardization and even in developing their own links with the rest of the world. Recent proposals put forward by the European Commission can be seen as an attempt to reduce that autonomy. These proposals emphasize the speed of, and stakeholder involvement in, standards production, which we further suggest are somewhat conflicting aims.

  18. Weak Interactions: From Current-Current to Standard Model and Beyond

    OpenAIRE

    Mohapatra, Rabindra N.

    2012-01-01

    Comment: 26 pages; Versions of this article will appear as a chapter in the book "Hundred years of sub-atomic physics" edited by Ernest Henley, to be published by World Scientific Publishing and as an article in International Journal of Theoretical Physics, WSPC (2012)

  19. American History's Problem with Standardized Testing

    Science.gov (United States)

    McCoog, Ian J.

    2005-01-01

    This article looks at current research concerning how students best learn the discipline of history, commentaries both in favor of and against standardized testing, and basic philosophical beliefs about the discipline. It explains methods of how to incorporate differentiated lessons and performance based assessments to NCLB standards and…

  20. Construct Validation of Content Standards for Teaching

    Science.gov (United States)

    van der Schaaf, Marieke F.; Stokking, Karel M.

    2011-01-01

    Current international demands to strengthen the teaching profession have led to an increased development and use of professional content standards. The study aims to provide insight in the construct validity of content standards by researching experts' underlying assumptions and preferences when participating in a delphi method. In three rounds 21…