WorldWideScience

Sample records for adult cancer csr

  1. CSR1 Suppresses Tumor Growth and Metastasis of Prostate Cancer

    OpenAIRE

    Yu, Guoying; Tseng, George C.; Yu, Yan Ping; Gavel, Tim; Nelson, Joel; Wells, Alan; Michalopoulos, George; Kokkinakis, Demetrius; Luo, Jian-Hua

    2006-01-01

    Prostate cancer is frequent among men over 45 years of age, but it generally only becomes lethal with metastasis. In this study, we identified a gene called cellular stress response 1 (CSR1) that was frequently down-regulated and methylated in prostate cancer samples. Survival analysis indicated that methylation of the CSR1 promoter, and to a lesser extent down-regulation of CSR1 protein expression, was associated with a high rate of prostate cancer metastasis. Forced expression of CSR1 in pr...

  2. CSR1 suppresses tumor growth and metastasis of prostate cancer.

    Science.gov (United States)

    Yu, Guoying; Tseng, George C; Yu, Yan Ping; Gavel, Tim; Nelson, Joel; Wells, Alan; Michalopoulos, George; Kokkinakis, Demetrius; Luo, Jian-Hua

    2006-02-01

    Prostate cancer is frequent among men over 45 years of age, but it generally only becomes lethal with metastasis. In this study, we identified a gene called cellular stress response 1 (CSR1) that was frequently down-regulated and methylated in prostate cancer samples. Survival analysis indicated that methylation of the CSR1 promoter, and to a lesser extent down-regulation of CSR1 protein expression, was associated with a high rate of prostate cancer metastasis. Forced expression of CSR1 in prostate cancer cell lines DU145 and PC3 resulted in a two- to threefold decrease in colony formation and a 10-fold reduction in anchorage-independent growth. PC3 cells stably expressing CSR1 had an average threefold decrease in their ability to invade in vitro. Expression of CSR1 in PC3 cell xenografts produced a dramatic reduction (>8-fold) in tumor size, rate of invasion (0 versus 31%), and mortality (13 versus 100%). The present findings suggest that CSR1 is a potent tumor sup-pressor gene. PMID:16436673

  3. Oncogenic Activity of miR-650 in Prostate Cancer Is Mediated by Suppression of CSR1 Expression

    OpenAIRE

    Zuo, Ze-Hua; Yu, Yan P.; Ding, Ying; Liu, Silvia; Martin, Amantha; Tseng, George; Luo, Jian-Hua

    2015-01-01

    Cellular stress response 1 (CSR1) is a tumor suppressor gene whose expression was frequently down-regulated in prostate cancer. The mechanism of its down-regulation, however, is not clear. Here, we show that the 3′ untranslated region of CSR1 contains a target site of miR-650. High level of miR-650 was found in prostate cancer samples and cell lines. Degradation of miR-650 by specific inhibitor dramatically increased the expression levels of CSR1. Interaction between miR-650 and its target si...

  4. Oncogenic Activity of miR-650 in Prostate Cancer Is Mediated by Suppression of CSR1 Expression.

    Science.gov (United States)

    Zuo, Ze-Hua; Yu, Yan P; Ding, Ying; Liu, Silvia; Martin, Amantha; Tseng, George; Luo, Jian-Hua

    2015-07-01

    Cellular stress response 1 (CSR1) is a tumor suppressor gene whose expression was frequently down-regulated in prostate cancer. The mechanism of its down-regulation, however, is not clear. Here, we show that the 3' untranslated region of CSR1 contains a target site of miR-650. High level of miR-650 was found in prostate cancer samples and cell lines. Degradation of miR-650 by specific inhibitor dramatically increased the expression levels of CSR1. Interaction between miR-650 and its target site in the 3' untranslated region was validated through luciferase reporter system. Mutation at the target site completely abrogated the activity of miR-650 on the 3' untranslated region of CSR1. Inhibition of miR-650 reversed the expression suppression of CSR1, suppressed colony formation, and blocked cell cycle entry to the S phase of both PC3 and DU145 cells. Animal model showed significant decrease of tumor volume, rate of metastasis, and mortality of severe combined immunodeficient mice xenografted with PC3 or DU145 cells transformed with inhibitor of miR-650. Our analyses demonstrate that suppression of CSR1 expression is a novel mechanism critical for the oncogenic activity of miR-650. PMID:25956032

  5. Adult Cancers in Adolescents and Young Adults.

    Science.gov (United States)

    Laurence, Valérie; Marples, Maria; Stark, Daniel P

    2016-01-01

    The pattern of cancer seen in young people changes with increasing age, transitioning from childhood- to adult-type cancer in adolescence and the third decade. The risk factors, presentation and biology of cancer in young adults differ from those in the older adult population. Factors of particular significance in adolescents and young adults (AYAs) include genetic predisposition to adult-type cancer, diagnostic uncertainty, long-term morbidity and considerations of fertility. New systemic therapies are being introduced that can prolong life and even increase the chance of cure, but the impact on AYAs is uncertain, as these patients are often under-represented in clinical trials. Here, we discuss the management of AYAs with 3 of the most common cancers affecting adults, when they emerge in the AYA populations, and therefore are currently met by medical oncologists - breast cancer, colorectal cancer and melanoma. PMID:27595357

  6. CSR STRATEGIES

    OpenAIRE

    LAURENTIU BARANGA; ION STEGAROIU

    2011-01-01

    Corporate Social Responsibility (CSR) has got three components: economic responsibility of shareholders, corporate environmental responsibility, corporate responsibility of the society. Each component of the CSR has its own features, according to which adequate individual behaviour is established. Knowing these features is very important in CSR strategy development.

  7. CSR communication

    DEFF Research Database (Denmark)

    Golob, Ursa; Podnar, Klement; Elving, Wim;

    2013-01-01

    a summary of the state of CSR communication knowledge. Design/methodology/approach – The existing literature on CSR communication was approached via systematic review. with a combination of conventional and summative qualitative content analysis. The final dataset contained 90 papers from two main business...... communications. The most important outlets for CSR communication-related topics are Journal of Business Ethics and Corporate Communications: An International Journal. Originality/value – This paper represents the first attempt to perform a systematic and comprehensive overview of CSR communication papers......Purpose – This paper aims to introduce the special issue on CSR communication attached to the First International CSR Communication Conference held in Amsterdam in October 2011. The aim of the introduction is also to review CSR communication papers published in scholarly journals in order to make...

  8. Adolescents and Young Adults with Cancer

    Science.gov (United States)

    ... Adults with Cancer Reports, Research, and Literature Quiz Adolescents and Young Adults with Cancer Types of Cancers ... Fund for Young Adults Vital Options Teens and Adolescents CureSearch Starlight Children's Foundation Teens Living with Cancer ...

  9. Political CSR

    DEFF Research Database (Denmark)

    Jeppesen, Søren; Morsing, Mette

    We engage a discussion of political CSR in SMEs in an African context. Based on critical observations on Western MNC CSR action in emerging economies that holds counterproductive implications for social development, political economists have argued that business profit far more than society in de...... development in local African communities. Our findings extend political CSR research by directing attention to how the corporate influence in developing economies does not only emerge from MNCs but is also established and retained by SMEs CSR work.......We engage a discussion of political CSR in SMEs in an African context. Based on critical observations on Western MNC CSR action in emerging economies that holds counterproductive implications for social development, political economists have argued that business profit far more than society...... in developing economies from CSR. In this paper we argue that local SMEs CSR work have strong influence in developing economies, that also includes counterproductive influence for social development. Based on empirical findings from African countries, we conceptualize how CSR in African SMEs differ from...

  10. How childhood cancers are different from adult cancers

    Science.gov (United States)

    ... page: //medlineplus.gov/ency/patientinstructions/000845.htm How childhood cancers are different from adult cancers To use ... children with cancer can be cured. Types of Childhood Cancers Cancer in children is rare, but some ...

  11. CSR i detailmarkedet

    OpenAIRE

    Nielsen, Tobias; Jensen, Kristina; Friis, Christina

    2015-01-01

    This report examines CSR from the problem “which benefits does Rema 1000 get through their CSR initiatives and can CSR be viewed as a market strategy.” To help answer this problem, three questions have been made which helps with the analysis: 1) Why do Rema 1000 make CSR? 2) Which stakeholders benefits from Rema 1000 CSR initiatives? 3) Why is CSR viewed as an integrated norm on the retail market? This report also formulates a hypothesis “CSR have nothing or very little to do with Soc...

  12. CSR and Beyond

    DEFF Research Database (Denmark)

    Morsing, Mette; Strand, Robert

    2014-01-01

    Review of: CSR and Beyond. A Nordic Perspective Edited by Atle Midttun (Oslo: Cappelen Damm Akademisk, 2013)......Review of: CSR and Beyond. A Nordic Perspective Edited by Atle Midttun (Oslo: Cappelen Damm Akademisk, 2013)...

  13. CSR as Governmentality

    OpenAIRE

    Vallentin, Steen; Murillo, David

    2009-01-01

    Modern governmental approaches to CSR (corporate social responsibility) have two distinguishing traits: they tend to define competitiveness as their primary concern and to make use of liberal and indirect means of steering. Contributing to a political understanding of CSR and focusing empirically on developments within the EU, this paper approaches CSR governance in general and competitiveness-driven CSR governance in particular from the point of view of an analytics of governmentality – thus...

  14. CSR og social udvikling

    OpenAIRE

    Marcussen, Helle Hye Secher; Sørensen, Johanne Wulff; Vodstrup, Ellis Hannah

    2010-01-01

    This project deals with the correlation between CSR and social development. Through an analysis of six Danish transnational companies’ CSR strategies, we examine to what extent CSR can contribute to a potential social development in development countries. Initially we define the concepts CSR and development according to our research question. This means that we theoretically specify development to the social aspects of development which are as follows; income, security at work, health, ...

  15. Business Ethics in CSR

    OpenAIRE

    Birkvad Bernth, Camilla; Houmøller Mortensen, Kasper; Calles, Mark Benjamin; Wind, Martin; Saalfeldt, Rie

    2013-01-01

    This project seeks to dissect the advent of CSR in business practice from the view of ethics. We perform this by laying out the theories of CSR, business ethics, deontology and utilitarianism. We then use the case studies of Lundbeck, The Body Shop, and British American Tobacco, to dissect some productions of CSR. These are compared to the above mentioned theories on ethics. We conclude that business ethics and CSR are only as good as the ethical base upon which they are built.

  16. CSR in SMEs

    DEFF Research Database (Denmark)

    Lund-Thomsen, Peter; Jamali, Dima; Vives, Antonio

    (Fox, 2005). In fact, when it comes to their role in promoting corporate social responsibility (CSR) in developing countries, the verdict is still out there in terms of the extent to which SMEs engage in CSR, and whether their CSR involvement makes any difference to the profitability of firms, workers......, and the environment in the South....

  17. Strategic CSR in Afghanistan

    DEFF Research Database (Denmark)

    Azizi, Sameer

    CSR is a rising phenomena in Afghanistan – but why are firms concerned about CSR in a least-developed context such as Afghanistan, and what are the strategic benefits? This paper is one of the first to explore these CSR issues in a least-developed country. It does so by focusing on CSR in the Afg......CSR is a rising phenomena in Afghanistan – but why are firms concerned about CSR in a least-developed context such as Afghanistan, and what are the strategic benefits? This paper is one of the first to explore these CSR issues in a least-developed country. It does so by focusing on CSR...... advantages through CSR in Afghanistan, and if so which and how these strategic benefits are gained. The paper shows that the developmental challenges of Afghanistan are the key explanations for why companies engage in CSR. Roshan has engaged in proactive CSR to overcome the contextual barriers for growth......’, but is based on a ‘license to operate’ motivation, where businesses have free room for maneuvering CSR towards their strategic priorities and business goals. Whether this creates a ‘shared value’ for both business and in particularly for the society is however still questionable....

  18. CSR communication: quo vadis?

    NARCIS (Netherlands)

    U. Golob; K. Podnar; W.J. Elving; A. Ellerup Nielsen; C. Thomsen; F. Schultz

    2013-01-01

    Purpose - This paper aims to introduce the special issue on CSR communication attached to the First International CSR Communication Conference held in Amsterdam in October 2011. The aim of the introduction is also to review CSR communication papers published in scholarly journals in order to make a

  19. CSR in SMEs

    DEFF Research Database (Denmark)

    Lund-Thomsen, Peter; Jamali, Dima; Vives, Antonio

    2014-01-01

    Purpose -The aim of this article is to analyse the potential and limitations of donor-financed management tools that seek to promote CSR in small and medium-sized enterprises in developing countries. Drawing on key insights from three streams of literature relating to institutional theory, critical...... perspectives on CSR in developing countries, and the literature on CSR and SMEs in the developing world, we analyze the potential and limits of donor-financed management tools aimed at promoting CSR in developing country SMEs. Design/methodology/approach - Using official UN and OECD lists of all multilateral...... and bilateral donor agencies we identified 38 donors that might have produced such CSR tools. We contacted them via e-mail and/or telephone, and conductied an extensive internet search with the aim of identifying whether they had developed management tools aimed at promoting CSR in SMEs in developing countries...

  20. CSR as Aspirational Talk

    DEFF Research Database (Denmark)

    Christensen, Lars Thøger; Morsing, Mette; Thyssen, Ole

    2013-01-01

    and that such discrepancies have the potential to stimulate CSR improvements. We draw on a research tradition that regards communication as performative to challenge the conventional assumption that CSR communication is essentially superficial, as opposed to CSR action. In addition, we extend notions of organizational......Most writings on corporate social responsibility (CSR) treat lack of consistency between organizational CSR talk and action as a serious problem that needs to be eliminated. In this article, we argue that differences between words and action are not necessarily a bad thing...... hypocrisy to argue that aspirational CSR talk may be an important resource for social change, even when organizations do not fully live up to their aspirations....

  1. Three Tiers of CSR

    DEFF Research Database (Denmark)

    Aggerholm, Helle Kryger; Trapp, Leila

    2014-01-01

    Heightened concern with global issues has led to shifts in corporate social responsibility (CSR) programs. To capture the distinct nature of this global focus, researchers have developed a three-generation CSR typology. In this paper we first evaluate the usefulness of this typology...... for understanding corporate approaches to CSR by examining how several companies position themselves thematically in CEO introductions to sustainability reports. On the basis of this, we then evaluate the practical value of this typology for assisting those who work with CSR strategy. The analysis revealed...... expressions of all three CSR generations, with third generation thinking being apparent, but not dominant. It also verified that the three-generation CSR typology can be an instructive means of both evaluating as well as framing a company’s approach to sustainability, though with modifications. On the basis...

  2. Communicating CSR is More Challenging than Paying CSR

    OpenAIRE

    Supriya Motwani

    2012-01-01

    In spite of the research on CSR being 50 years old, there is still no common definition of CSR. This field of study is not only theoretical & conceptually poor, but is also empirically unexplored. This is also true for CSR communication. CSR activities need to communicate because they may influence opinion leader’s behavior regarding a target organization. This potential for exploring CSR communication has lead us to develop a study that focuses on CSR communication practice & it’s challenges...

  3. Alignment for CSR

    International Nuclear Information System (INIS)

    Cooled Storage Ring of Heavy Ion Research Facility in Lanzhou (HIRFL-CSR) belongs to China great scientific project in China. The alignment for it is very difficult because of very large area and very high accuracy. For the special case in HIRFL-CSR, some new methods and new instruments are used, including the construction of survey control network, the usage of laser tracker, and CSR alignment database system with applications developed to store and analyze data. The author describes the whole procedure of CSR alignment

  4. Torm's CSR-karakter

    OpenAIRE

    Pyke, Niklas Bruhn

    2012-01-01

    This study investigate how the CSR of an organisation can be viewed in terms of its underlying CSR character. The study is examining the development of Torm´s CSR character, by selecting two specific parameters: identity orientation and strategic consistency. With the focus on Torm´s identity orientation, the study interprets how Torm relate to its stakeholders in their CSR-reports from 2007-2012 and concludes, that Torm have changed their orientation from a hybrid of collectivistic and indiv...

  5. Reporting consistently on CSR

    DEFF Research Database (Denmark)

    Thomsen, Christa; Nielsen, Anne Ellerup

    2006-01-01

    This chapter first outlines theory and literature on CSR and Stakeholder Relations focusing on the different perspectives and the contextual and dynamic character of the CSR concept. CSR reporting challenges are discussed and a model of analysis is proposed. Next, our paper presents the results...... of a case study showing that companies use different and not necessarily consistent strategies for reporting on CSR. Finally, the implications for managerial practice are discussed. The chapter concludes by highlighting the value and awareness of the discourse and the discourse types adopted...

  6. Comorbidity in older adults with cancer.

    Science.gov (United States)

    Williams, Grant R; Mackenzie, Amy; Magnuson, Allison; Olin, Rebecca; Chapman, Andrew; Mohile, Supriya; Allore, Heather; Somerfield, Mark R; Targia, Valerie; Extermann, Martine; Cohen, Harvey Jay; Hurria, Arti; Holmes, Holly

    2016-07-01

    Comorbidity is an issue of growing importance due to changing demographics and the increasing number of adults over the age of 65 with cancer. The best approach to the clinical management and decision-making in older adults with comorbid conditions remains unclear. In May 2015, the Cancer and Aging Research Group, in collaboration with the National Cancer Institute and the National Institute on Aging, met to discuss the design and implementation of intervention studies in older adults with cancer. A presentation and discussion on comorbidity measurement, interventions, and future research was included. In this article, we discuss the relevance of comorbidities in cancer, examine the commonly used tools to measure comorbidity, and discuss the future direction of comorbidity research. Incorporating standardized comorbidity measurement, relaxing clinical trial eligibility criteria, and utilizing novel trial designs are critical to developing a larger and more generalizable evidence base to guide the management of these patients. Creating or adapting comorbidity management strategies for use in older adults with cancer is necessary to define optimal care for this growing population. PMID:26725537

  7. Cancer: Unique to Older Adults

    Science.gov (United States)

    ... Tuesday, August 11, 2015 Join our e-newsletter! Aging & Health A to Z Cancer Unique to Older ... effect of your narcotic medications. These include: antidepressants anti-epileptic (anti-seizure) drugs steroids. Radiation for pain ...

  8. CSR schemes in agribusiness

    DEFF Research Database (Denmark)

    Pötz, Katharina Anna; Haas, Rainer; Balzarova, Michaela

    2013-01-01

    of schemes that can be categorized on focus areas, scales, mechanisms, origins, types and commitment levels. Research limitations/implications – The findings contribute to conceptual and empirical research on existing models to compare and analyse CSR standards. Sampling technique and depth of analysis limit...... this research, but the authors offer insights into patterns of CSR standard development in agribusiness and point to important research avenues. Practical implications – These findings can help agribusiness managers to select and analyse CSR standards and other forms of CSR guidance. Social implications...... – Standard and guidance setting activities can be expected to have real-life effects on CSR outcomes. These effects need to be better understood by policy makers and stakeholders. The authors' meta-analysis contributes to further research on who or what influences standard development. Originality...

  9. CSR in Afghanistan

    DEFF Research Database (Denmark)

    Azizi, Sameer; Jamali, Dima

    2016-01-01

    explicit CSR themes. Research limitations/implications: – The findings are based on CSR practices that are explicitly stated and do not include informal and/or implicit business-society practices in such contexts. Originality/value: – This paper combines the literature on areas of limited statehood......Purpose: – The purpose of this paper is to explain the emergence of CSR in Afghanistan as a novel context in the South-Asian CSR debate. Design/methodology/approach: – The findings of the paper are based on case studies of four corporations in the Afghan mobile telecommunications industry. Multiple...... space for manoeuvring for non-state actors to play a pivotal role in business-society relations. The paper highlights that the CSR practices are driven by the multi-level organisational field that through a unique blend of global coercive, mimetic and normative pressures lead to convergence around...

  10. Communicating CSR is More Challenging than Paying CSR

    Directory of Open Access Journals (Sweden)

    Supriya Motwani

    2012-06-01

    Full Text Available In spite of the research on CSR being 50 years old, there is still no common definition of CSR. This field of study is not only theoretical & conceptually poor, but is also empirically unexplored. This is also true for CSR communication. CSR activities need to communicate because they may influence opinion leader’s behavior regarding a target organization. This potential for exploring CSR communication has lead us to develop a study that focuses on CSR communication practice & it’s challenges. Communicating CSR means not only communicating a company’s behavior through standards or codes of conduct, but also communicating about very long projects. From this argument, we draw the conclusion that conscious communication of CSR is difficult, but necessary. Since creating stakeholder awareness & managing stakeholder attributes are key prerequisite for reaping the strategic benefits of any business initiative, it is imperative for board members & senior executives instituting a CSR program to have deeper understanding of key issues related to CSR communication. These include questions surrounding what to communicate, where to communicate, as well as an understanding of the factors that influence the effectiveness of a CSR campaign. Communicating CSR is a very delicate matter, & a key challenge of CSR communication is how to minimize stakeholder skepticism & to convey intrinsic motives in a company’s CSR activities. This paper explores the various communication channels for CSR, their communication objectives, & challenges posed by the companies for communicating CSR.

  11. Analyza CSR v podniku

    OpenAIRE

    Kasl, Michael

    2015-01-01

    The Bachelor thesis deals with the analysis of corporate social responsibility (CSR) at PwC. The thesis is divided into theoretical and practical part. The theoretical part explains basic concepts concerning the corporate social responsibility, as well as the history of CSR and reasons for implementing it. The practical part of the thesis is focused on the PwC network, mainly on PwC Czech Republic. Mentioned CSR activities done by PwC CZ and international strategy are used for comparison and ...

  12. The Ribonucleoprotein Csr Network

    Directory of Open Access Journals (Sweden)

    Ethel Seyll

    2013-11-01

    Full Text Available Ribonucleoprotein complexes are essential regulatory components in bacteria. In this review, we focus on the carbon storage regulator (Csr network, which is well conserved in the bacterial world. This regulatory network is composed of the CsrA master regulator, its targets and regulators. CsrA binds to mRNA targets and regulates translation either negatively or positively. Binding to small non-coding RNAs controls activity of this protein. Expression of these regulators is tightly regulated at the level of transcription and stability by various global regulators (RNAses, two-component systems, alarmone. We discuss the implications of these complex regulations in bacterial adaptation.

  13. Strategisk CSR i store virksomheder

    OpenAIRE

    Færch, Maya Lauridsen

    2013-01-01

    This thesis examines the institutionalization of strategic CSR in large corporations in Denmark. The study focuses on how strategic CSR has become a part of the overall legitimizing paradigms in the Danish society, and whether the use of strategic CSR results in isomorphic tendencies among large corporations in Denmark. Furthermore, it examines how large corporations institutionalize strategic CSR in regards to the integration of strategic CSR in operational activities and the embedment of st...

  14. Religiosity, CSR attitudes, and CSR behavior : An empirical study of executives’ religiosity and CSR

    NARCIS (Netherlands)

    Mazereeuw, C.; Graafland, J.J.; Kaptein, M.

    2014-01-01

    In this paper, we examine the relationship between Christian religiosity, attitudes towards corporate social responsibility (CSR), and CSR behavior of executives. We distinguish four types of CSR attitudes and five types of CSR behavior. Based on empirical research conducted among 473 Dutch executiv

  15. CSR as Imperialism

    DEFF Research Database (Denmark)

    Lund-Thomsen, Peter; Khan, Farzad Rafi

    2011-01-01

    the interpretations given to Western-based CSR initiatives by local manufacturers. Data from two qualitative research projects on CSR initiatives in the soccer ball industry of Sialkot, Pakistan, are utilized to explore this issue in an inductive and exploratory manner. The article suggests that many soccer ball......The voices of local manufacturers have largely been overlooked in academic and policy debates on corporate social responsibility (CSR) in the developing world. This article makes a contribution towards filling this gap in the literature by explicitly taking a phenomenological approach that maps...... manufacturers in Sialkot perceive CSR as part of the wider historic project of Western imperialism in the developing world through which economic resources are extracted from local manufacturers while their perceptions of what constitutes socially responsible behaviour are delegitimized. This counter...

  16. CSR in Industrial Clusters

    DEFF Research Database (Denmark)

    Lund-Thomsen, Peter; Pillay, Renginee G.

    2012-01-01

    Purpose – The paper seeks to review the literature on CSR in industrial clusters in developing countries, identifying the main strengths, weaknesses, and gaps in this literature, pointing to future research directions and policy implications in the area of CSR and industrial cluster development...... in this field and their comments incorporated in the final version submitted to Corporate Governance. Findings – The article traces the origins of the debate on industrial clusters and CSR in developing countries back to the early 1990s when clusters began to be seen as an important vehicle for local economic...... development in the South. At the turn of the millennium the industrial cluster debate expanded as clusters were perceived as a potential source of poverty reduction, while their role in promoting CSR among small and medium-sized enterprises began to take shape from 2006 onwards. At present, there is still...

  17. CSR at Daimler

    OpenAIRE

    Geipel, Teresa

    2013-01-01

    Social responsibility of companies is a topic which has been more and more discussed during the last years. A lot of initiatives were started by the headline of Corporate Social Responsibility. But are these initiatives just window dressing or have employees really internalized the importance of Corporate Social Responsibility (CSR) and act according to the corporate principles? This project investigates on the CSR strategy and its implementation at the German multinational cooperation Daimle...

  18. BAT, CSR and Lobbying

    OpenAIRE

    Williams, Sarah

    2008-01-01

    Due to the nature of their product, tobacco companies face much criticism from many fronts, particularly the media and NGOs. This public criticism has meant tobacco companies strive to implement sound and commendable CSR principles, initiatives, and codes, often voluntarily reporting on their CSR or sustainability activities. Tobacco companies have also faced criticism regarding their lobbying practices since the 1950s and onwards. Many commentators feel they should be excluded from consu...

  19. CSR, tax and development

    OpenAIRE

    Jenkins, Rhys; Newell, P.

    2013-01-01

    This article explores and critically examines the connections between tax and development on the one hand and tax and corporate social responsibility (CSR) on the other. It does so because, while there is increasing recognition of the importance of taxation to efforts to resource the state and to finance ways of tackling poverty, there is a surprising lack of attention to tax avoidance and evasion as a CSR issue for transnational corporations operating in the South, even among those companies...

  20. CSR, H&M

    OpenAIRE

    Krohn Bjerggaard Hansen, Thomas; Halveg Olesen, Emil; Mejdahl Jeppesen, Peter

    2016-01-01

    This assignment deals with Corporate Social Responsibility (CSR), how the term and the interpretation of it have developed through time. Furthermore, the assignment analyze discus how to place the responsibility and in which scope it is fair to place it within. Is it the companies, the consumers or the governments’ responsibility, or is it a mix of the three characters? In the first analysis, we use already existing empirical data to describe the history of CSR, how the term theoretically ...

  1. Interaction of CSR1 with XIAP reverses inhibition of caspases and accelerates cell death.

    Science.gov (United States)

    Zheng, Zhong-Liang; Tan, Lang-Zhu; Yu, Yan P; Michalopoulos, George; Luo, Jian-Hua

    2012-08-01

    Cellular Stress Response 1 (CSR1) is a tumor suppressor gene that is located at 8p21, a region that is frequently deleted in prostate cancer as well as a variety of human malignancies. Previous studies have indicated that the expression of CSR1 induces cell death. In this study, we found that CSR1 interacts with X-linked Inhibitor of Apoptosis Protein (XIAP), using yeast two-hybrid screening analyses. XIAP overexpression has been found in many human cancers, and forced expression of XIAP blocks apoptosis. Both in vitro and in vivo analyses indicated that the C-terminus of CSR1 binds XIAP with high affinity. Through a series of in vitro recombinant protein-binding analyses, the XIAP-binding motif in CSR1 was determined to include amino acids 513 to 572. Targeted knock-down of XIAP enhanced CSR1-induced cell death, while overexpression of XIAP antagonized CSR1 activity. The binding of CSR1 with XIAP enhanced caspase-9 and caspase-3 protease activities, and CSR1-induced cell death was dramatically reduced on expression of a mutant CSR1 that does not bind XIAP. However, a XIAP mutant that does not interact with caspase-9 had no impact on CSR1-induced cell death. These results suggest that cell death is induced when CSR1 binds XIAP, preventing the interaction of XIAP with caspases. Thus, this study may have elucidated a novel mechanism by which tumor suppressors induce cell death. PMID:22683311

  2. Conceptions of CSR in Japan

    DEFF Research Database (Denmark)

    Lystbæk, Christian Tang

    2014-01-01

    The objective of this paper is to advance an analysis of different conceptions of CSR in Japan after the Fukushima accident. The literature on CSR suggests that CSR is a complex term that has been open to a variety of interpretations. Until recently, CSR was mainly incorporated into Japanese comp...... challenge for CSR in Japan is to deal with the preconceptions about the nature of business activities amongst managers, politicians, and other CSR agents.......The objective of this paper is to advance an analysis of different conceptions of CSR in Japan after the Fukushima accident. The literature on CSR suggests that CSR is a complex term that has been open to a variety of interpretations. Until recently, CSR was mainly incorporated into Japanese...... concerns have raised crucial questions about environmental issues with regards to CSR. How do Japanese companies incorporate environmental issues into their CSR aims and achievements? What is the next strategic challenge for CSR in Japan? This paper will analyze the conceptualization of CSR in TEPCO...

  3. Embedding CSR at Burckhardt Compression

    OpenAIRE

    Nimruji Jammulamadaka; Dinesh B. Khonde

    2011-01-01

    This case deals with a medium-sized engineering company's experiences with initiating CSR. It covers aspects like the rationale for CSR, its relationship with strategy, participation in CSR and speed breakers on the path to building a CSR culture in the company. After sustained growth over a few years, the top management has decided to look beyond profits and embarked on CSR. They allocated 2% of their PBT to their Trust to oversee CSR activities. They began the activities about one and a hal...

  4. CSR1 induces cell death through inactivation of CPSF3.

    Science.gov (United States)

    Zhu, Z-H; Yu, Y P; Shi, Y-K; Nelson, J B; Luo, J-H

    2009-01-01

    CSR1 (cellular stress response 1), a newly characterized tumor-suppressor gene, undergoes hypermethylation in over 30% of prostate cancers. Re-expression of CSR1 inhibits cell growth and induces cell death, but the mechanism by which CSR1 suppresses tumor growth is not clear. In this study, we screened a prostate cDNA library using a yeast two-hybrid system and found that the cleavage and polyadenylation-specific factor 3 (CPSF3), an essential component for converting heteronuclear RNA to mRNA, binds with high affinity to the CSR1 C terminus. Further analyses determined that the binding motifs for CPSF3 are located between amino acids 440 and 543. The interaction between CSR1 and CPSF3 induced CPSF3 translocation from the nucleus to the cytoplasm, resulting in inhibition of polyadenylation both in vitro and in vivo. Downregulation of CPSF3 using small interfering RNA induced cell death in a manner similar to CSR1 expression. A CSR1 mutant unable to bind to CPSF3 did not alter CPSF3 subcellular distribution, did not inhibit its polyadenylation activity and did not induce cell death. In summary, CSR1 appears to induce cell death through a novel mechanism by hijacking a critical RNA processing enzyme. PMID:18806823

  5. Risk of thyroid cancer, brain cancer, and non-Hodgkin lymphoma after adult leukemia

    DEFF Research Database (Denmark)

    Nielsen, Sune F; Bojesen, Stig E; Birgens, Henrik S;

    2011-01-01

    Patients with childhood leukemia surviving into adulthood have elevated risk of developing thyroid cancer, brain cancer, and non-Hodgkin lymphoma (NHL); these risks cannot automatically be extrapolated to patients surviving adult leukemia. We tested whether survivors of adult leukemia...

  6. Home care to Older adult with cancer

    International Nuclear Information System (INIS)

    Objective: Home care of the elderly with cancer. After the development of a program of oncology home care and over a period of five years, we believe that the evaluation allows us to have our proposal and challenges in the continuity of the program. This evidence is based in our old advanced Uruguayan population, and consequently increase this cancer population, we should define which pointed toward our objective, in order to get the best quality life. After one year with a project based on general rules, the evidence threw an evaluation, that we should review the model of care with which we were working. We continue to Auto-care model Dorothea Orem. The main objective became quality of life:Take care as the primary Older Adult; Specific care their cancer to become symptomatic secondary complications to the evolution of tumor biology; Secondary prevention of cause therapeutic effect; Family integration, without changing the pace of life that the elderly had before being with cancer. Nursing challenge: Maintain autonomy achieved in these 5 years. Deepen the social equilibrium that we are committed daily between patient and family.Do not miss the professionalism achieved today.Proposal for nursing: Consider a wide field of nursing and for this achievement is need knowledge of 2nd level of community work, knowledge Clinical knowledge in Oncology Nursing, autonomy in decision making. For older adults with cancer: No out of its middle. Maintain priority habits and customs. Do not let it lose their self-esteem with their own values. Caution changes must take care to better manage the evolution of their illness. Conclusion: Oncology nursing is a specialty. Without this formation will be ever more away the development of these programs in our environment, or fall in applying for only economic convenience, losing professionalism. Our population is increasing

  7. Governmentalities of CSR

    DEFF Research Database (Denmark)

    Vallentin, Steen

    2015-01-01

    This paper investigates the roles that Danish government has played in the development of corporate social responsibility (CSR). Denmark has emerged as a first mover among the Scandinavian countries when it comes to CSR. We argue that government has played a pivotal role in making this happen...... by a lack of common direction and that we need to approach it on such terms. In order to provide a critical account of ‘the Danish model’ we apply a governmentality perspective that allows us to stress political difference. We argue that Danish government policy consists of three distinct regimes......, and that this reflects strong traditions of regulation, corporatism and active state involvement. However, there is no unitary “Danish model of CSR” being promoted by government. Although Danish society is often associated with a model of consensus, our claim is that Danish government policy on CSR is characterized...

  8. Gaps in nutritional research among older adults with cancer

    Science.gov (United States)

    Presley, Carolyn J.; Dotan, Efrat; Soto-Perez-de-Celis, Enrique; Jatoi, Aminah; Mohile, Supriya G.; Won, Elizabeth; Alibhai, Shabbir; Kilari, Deepak; Harrison, Robert; Klepin, Heidi D.; Wildes, Tanya M.; Mustian, Karen; Demark-Wahnefried, Wendy

    2016-01-01

    Nutritional issues among older adults with cancer are an understudied area of research despite significant prognostic implications for treatment side effects, cancer-specific mortality, and overall survival. In May of 2015, the National Cancer Institute and the National Institute on Aging co-sponsored a conference focused on future directions in geriatric oncology research. Nutritional research among older adults with cancer was highlighted as a major area of concern as most nutritional cancer research has been conducted among younger adults, with limited evidence to guide the care of nutritional issues among older adults with cancer. Cancer diagnoses among older adults are increasing, and the care of the older adult with cancer is complicated due to multimorbidity, heterogeneous functional status, polypharmacy, deficits in cognitive and mental health, and several other non-cancer factors. Due to this complexity, nutritional needs are dynamic, multifaceted, and dependent on the clinical scenario. This manuscript outlines the proceedings of this conference including knowledge gaps and recommendations for future nutritional research among older adults with cancer. Three common clinical scenarios encountered by oncologists include (1) weight loss during anti-cancer therapy, (2) malnutrition during advanced disease, and (3) obesity during survivorship. In this manuscript, we provide a brief overview of relevant cancer literature within these three areas, knowledge gaps that exist, and recommendations for future research. PMID:27197919

  9. Gaps in nutritional research among older adults with cancer.

    Science.gov (United States)

    Presley, Carolyn J; Dotan, Efrat; Soto-Perez-de-Celis, Enrique; Jatoi, Aminah; Mohile, Supriya G; Won, Elizabeth; Alibhai, Shabbir; Kilari, Deepak; Harrison, Robert; Klepin, Heidi D; Wildes, Tanya M; Mustian, Karen; Demark-Wahnefried, Wendy

    2016-07-01

    Nutritional issues among older adults with cancer are an understudied area of research despite significant prognostic implications for treatment side effects, cancer-specific mortality, and overall survival. In May of 2015, the National Cancer Institute and the National Institute on Aging co-sponsored a conference focused on future directions in geriatric oncology research. Nutritional research among older adults with cancer was highlighted as a major area of concern as most nutritional cancer research has been conducted among younger adults, with limited evidence to guide the care of nutritional issues among older adults with cancer. Cancer diagnoses among older adults are increasing, and the care of the older adult with cancer is complicated due to multimorbidity, heterogeneous functional status, polypharmacy, deficits in cognitive and mental health, and several other non-cancer factors. Due to this complexity, nutritional needs are dynamic, multifaceted, and dependent on the clinical scenario. This manuscript outlines the proceedings of this conference including knowledge gaps and recommendations for future nutritional research among older adults with cancer. Three common clinical scenarios encountered by oncologists include (1) weight loss during anti-cancer therapy, (2) malnutrition during advanced disease, and (3) obesity during survivorship. In this manuscript, we provide a brief overview of relevant cancer literature within these three areas, knowledge gaps that exist, and recommendations for future research. PMID:27197919

  10. Gaps in nutritional research among older adults with cancer.

    Science.gov (United States)

    Presley, Carolyn J; Dotan, Efrat; Soto-Perez-de-Celis, Enrique; Jatoi, Aminah; Mohile, Supriya G; Won, Elizabeth; Alibhai, Shabbir; Kilari, Deepak; Harrison, Robert; Klepin, Heidi D; Wildes, Tanya M; Mustian, Karen; Demark-Wahnefried, Wendy

    2016-07-01

    Nutritional issues among older adults with cancer are an understudied area of research despite significant prognostic implications for treatment side effects, cancer-specific mortality, and overall survival. In May of 2015, the National Cancer Institute and the National Institute on Aging co-sponsored a conference focused on future directions in geriatric oncology research. Nutritional research among older adults with cancer was highlighted as a major area of concern as most nutritional cancer research has been conducted among younger adults, with limited evidence to guide the care of nutritional issues among older adults with cancer. Cancer diagnoses among older adults are increasing, and the care of the older adult with cancer is complicated due to multimorbidity, heterogeneous functional status, polypharmacy, deficits in cognitive and mental health, and several other non-cancer factors. Due to this complexity, nutritional needs are dynamic, multifaceted, and dependent on the clinical scenario. This manuscript outlines the proceedings of this conference including knowledge gaps and recommendations for future nutritional research among older adults with cancer. Three common clinical scenarios encountered by oncologists include (1) weight loss during anti-cancer therapy, (2) malnutrition during advanced disease, and (3) obesity during survivorship. In this manuscript, we provide a brief overview of relevant cancer literature within these three areas, knowledge gaps that exist, and recommendations for future research.

  11. Experiencing CSR in Asia

    DEFF Research Database (Denmark)

    Kampf, Constance Elizabeth

    2014-01-01

    This paper focuses on Corporate Social Responsibility (CSR) as strongly linked to expectations for corporations in the cultural con- texts in which they operate. Using an approach based in a macro-level for socio-technical design, it examines the interaction between digital activist efforts to (r...... into question the via- bility of CSR practices mediated by policy and NGOs, because busi- nesses appear to be simply adopting mediators’ perspectives to avoid a crisis rather than a building a strategy based on critical engagement with the issues....

  12. CSR Communication & SMEs

    OpenAIRE

    Eliasson, Malin; Smajovic, Senida

    2009-01-01

      Purpose: The purpose of this thesis is to investigate how SMEs in the Småland region define and communicate their CSR activities towards their stakeholders. Background: Corporate social responsbility is a topic that is widely discussed today. In many cases the CSR agenda has been adopted by many large corporations. However there is a demand from governmental bodies to spread this agenda further to include and engage small-to-medium enterprises (SMEs). The main reason for this approach is du...

  13. Childhood height, adult height, and the risk of prostate cancer

    DEFF Research Database (Denmark)

    Bjerregaard, Lise Geisler; Aarestrup, Julie; Gamborg, Michael;

    2016-01-01

    PURPOSE: We previously showed that childhood height is positively associated with prostate cancer risk. It is, however, unknown whether childhood height exerts its effects independently of or through adult height. We investigated whether and to what extent childhood height has a direct effect...... on the risk of prostate cancer apart from adult height. METHODS: We included 5,871 men with height measured at ages 7 and 13 years in the Copenhagen School Health Records Register who also had adult (50-65 years) height measured in the Danish Diet, Cancer and Health study. Prostate cancer status was obtained...... through linkage to the Danish Cancer Registry. Direct and total effects of childhood height on prostate cancer risk were estimated from Cox regressions. RESULTS: From 1996 to 2012, 429 prostate cancers occurred. Child and adult heights were positively and significantly associated with prostate cancer risk...

  14. CSR1 induces cell death through inactivation of CPSF3

    OpenAIRE

    Zhu, Z-H; Yu, YP; Shi, Y-K; Nelson, JB; Luo, J-H

    2008-01-01

    CSR1 (cellular stress response 1), a newly characterized tumor-suppressor gene, undergoes hypermethylation in over 30% of prostate cancers. Re-expression of CSR1 inhibits cell growth and induces cell death, but the mechanism by which CSR1 suppresses tumor growth is not clear. In this study, we screened a prostate cDNA library using a yeast two-hybrid system and found that the cleavage and polyadenylation-specific factor 3 (CPSF3), an essential component for converting heteronuclear RNA to mRN...

  15. Providing Southern Perspectives on CSR

    OpenAIRE

    Jeppesen, Søren; Kothuis, Bas

    2014-01-01

    The article seeks to contribute to the SMEs and CSR literature in developing countries by providing; a) a ‘Southern’ SME perspective, which includes the voices of managers and workers, b) a perspective of CSR, which opens up to informal CSR practices that SMEs undertake, and c) an analysis of the key institutional issues affecting the CSR practices of SMEs. It presents perceptions of CSR practices among 21 SMEs in the garment industry in South Africa, based on 40 interviews with managers and ...

  16. Can CSR be controlled?

    DEFF Research Database (Denmark)

    Kampf, Constance

    2009-01-01

    Associate Professor Constance Kampf talks about whether companies can control CSR or not, and she talks about the possible implications it can have if companies fail to live up their responsibilties. In that sense companies needs to consider the impact of the internet. She also gives advice on how...

  17. CSR as Corporate Political Activity

    DEFF Research Database (Denmark)

    Morsing, Mette; Roepstorff, Anne

    2015-01-01

    In this article, we develop a conceptual framework to understand how a company’s CSR identity becomes defined as a political activity destabilizing the strong identity–image relations. We draw on theories of political CSR and organizational identity–image relations to study how CSR emerges...... as a corporate political activity in a context where the corporate CSR work is first appreciated and later critiqued by the public in the wake of socio-political events. We analyse the micro-organizational processes in the context of macro-political level changes, and we refer to this as the ‘identity....... In this process, IKEA’s CSR identity becomes defined as a political and non-neutral activity. Our article contributes by bringing attention to the organizational level dynamics of political CSR by offering a conceptualization of how global and local socio-political events may disturb the alignment between CSR...

  18. CSR Model Implementation from School Stakeholder Perspectives

    Science.gov (United States)

    Herrmann, Suzannah

    2006-01-01

    Despite comprehensive school reform (CSR) model developers' best intentions to make school stakeholders adhere strictly to the implementation of model components, school stakeholders implementing CSR models inevitably make adaptations to the CSR model. Adaptations are made to CSR models because school stakeholders internalize CSR model practices…

  19. CSR : Structure for Responsibility

    OpenAIRE

    Adestam, Carina; Gunnmo, Sofia

    2008-01-01

    Many organisational flaws are consequences of unsuitable structure arrangements that do not support the organisation in its work towards goal accomplishment. The appropriateness of the structure is determined by how well it allows the organisation to respond to the environment in which it is active. Furthermore, an organisation is divided into parts with their own requirements on the structure. CSR is a concept that enables for a wider perspective of how to conduct business, thereby strengthe...

  20. The distinctive biology of cancer in adolescents and young adults.

    Science.gov (United States)

    Bleyer, Archie; Barr, Ronald; Hayes-Lattin, Brandon; Thomas, David; Ellis, Chad; Anderson, Barry

    2008-04-01

    One explanation for the relative lack of progress in treating cancer in adolescents and young adults is that the biology of malignant diseases in this age group is different than in younger and older persons, not only in the spectrum of cancers but also within individual cancer types and within the patient (host). Molecular, epidemiological and therapeutic outcome comparisons offer clues to this distinctiveness in most of the common cancers of adolescents and young adults. Translational and clinical research should not assume that the biology of cancers and patients is the same as in other age groups, and treatment strategies should be tailored to the differences.

  1. Cardiovascular Complications of Breast Cancer Therapy in Older Adults

    Science.gov (United States)

    Klem, Igor; Crowley, Anna Lisa; Patel, Manesh R.; Winchester, Mark A.; Owusu, Cynthia; Kimmick, Gretchen G.

    2011-01-01

    Older adults frequently have pre-existing and cancer-related risk factors for cardiovascular toxicity from cancer treatment. In this review, we discuss the risk factors and strategies for prevention and management of cardiovascular complications in older women with breast cancer. PMID:21737575

  2. HIRFL-CSR complex

    International Nuclear Information System (INIS)

    The construction and commissioning of HIRFL-CSR were finished in 2007. From 2000 to 2005 the subsystem and key devices of CSR were successfully fabricated, such as magnet, power supply, UHV system, e-cooler, electric-static deflector with the septum of 0.1 mm, and the fast-pulse kicker with the rise time of 150 ns. After that the CSR commissioning activities were performed in 2006 and 2007, including the accumulation of those heavy ions of C, Ar, Kr and Xe by the combination of stripping injection (STI) or multiple multi-turn injection (MMI) and e-cooling with a hollow e-beam, wide energy-range synchrotron ramping by changing the RF harmonic-number at mid-energy, the beam stacking in the experimental ring CSRe, the RIBs mass-measurement with the isochronous-mode in CSRe by using the time-of-flight method, and the ion beam slow-extraction from CSRm. (authors)

  3. CSR, SMEs and Social Capital

    DEFF Research Database (Denmark)

    Murillo, David; Vallentin, Steen

    2012-01-01

    behind these CSR actions must reflect their essentially pragmatic nature. Actions are linked to social values but also, more importantly, to the nature of the competitive environment c) Business ethics must seek common ground with other more sociological disciplines if it is to explain the reasons behind......This paper is a response to the opening of new lines of research on CSR and SMEs (Thompson & Smith, 1991; Spence, 1999; Moore & Smith, 2006; Spence, 2007). It seeks to explore the business case for CSR in this corporate segment. The paper, which is based on four case studies of medium-sized firms...... in the automotive sector, took the distinctive approach of trying to understand the nature of CSR-like activities developed not by best-in-class CSR-driven companies but by purely competitiveness-driven firms. The case studies provide explicit evidence that the CSR activities of SMEs and the notion of social...

  4. Space charge effects of CSR

    International Nuclear Information System (INIS)

    Cooler Storage Ring (CSR), and upgrading program planned at the Heavy Ion Research Facility in Lanzhou (HIRFL), will supply beams with higher quality and intensity. Space charge effects should be considered due to this magnitude of intensity in CSR. The concept and some phenomena of space charge effects are discussed. Space charge intensity limit and space charge tune shift of normal CSR operation are given. It is of significance for the construction and operation of the future facility

  5. CSR-kommunikation med omtanke

    OpenAIRE

    Skovgaard, Maja; Felbo-Kolding, Mia; Larsen, Peter Hjorth

    2007-01-01

    Strategic Corporate Social Responsibility communication has become a big challenge for companies today. Increasingly, investors, NGO’s, B2B customers and consumers want the companies to engage in CSR activities and to document and communicate them. But CSR communication is complicated by the fact that stakeholders not always want to hear about the companies’ efforts. Companies are often perceived as self-absorbed and are met with scepticism when they communicate their CSR efforts. In this pro...

  6. Cancer of the Testis

    Science.gov (United States)

    ... 1975-2013 Browse the Tables and Figures Access CSR Contents in PDF Generate Custom Reports About the ... Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2013/ , based on November 2015 SEER data ...

  7. Cancer of the Anus

    Science.gov (United States)

    ... 1975-2013 Browse the Tables and Figures Access CSR Contents in PDF Generate Custom Reports About the ... Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2013/ , based on November 2015 SEER data ...

  8. Cancer of the Larynx

    Science.gov (United States)

    ... 1975-2013 Browse the Tables and Figures Access CSR Contents in PDF Generate Custom Reports About the ... Cancer Institute. Bethesda, MD, http://seer.cancer.gov/csr/1975_2013/ , based on November 2015 SEER data ...

  9. Providing Southern Perspectives on CSR

    DEFF Research Database (Denmark)

    Jeppesen, Søren; Kothuis, Bas

    The article seeks to contribute to the SMEs and CSR literature in developing countries by providing; a) a ‘Southern’ SME perspective, which includes the voices of managers and workers, b) a perspective of CSR, which opens up to informal CSR practices that SMEs undertake, and c) an analysis of the...... are found to be important factors in explaining the CSR perceptions and level of practices. It is suggested that future research investigate the role of informal practices further and explore the role of institutional theory.......The article seeks to contribute to the SMEs and CSR literature in developing countries by providing; a) a ‘Southern’ SME perspective, which includes the voices of managers and workers, b) a perspective of CSR, which opens up to informal CSR practices that SMEs undertake, and c) an analysis...... of the key institutional issues affecting the CSR practices of SMEs. It presents perceptions of CSR practices among 21 SMEs in the garment industry in South Africa, based on 40 interviews with managers and 19 interviews with workers through the use of qualitative and quantitative interview frameworks...

  10. CSR i et foranderligt samfund

    OpenAIRE

    Meedom, Maria; Stokholm, Helle; Miara, Denice; á Lakjuni, Heidi; Dayyani, Navid

    2012-01-01

    CSR i et foranderligt samfund Dette projekt har fokus på samfundsansvar. I projektet henviser vi løbende til elementer fra Anthony Giddens strukturationsteori og modernitetsanalyse. Vi undersøger hvad der ligger i begrebet CSR og hvordan udviklingen af CSR har været i Danmark. Vi diskuterer de samfundsmæssige konsekvenser af forskellige holdninger til CSR. Dette gør vi ud fra teori af Friedman og Henderson, der ikke mener det er virksomhedernes ansvar og Freeman og Porter & Kramer der arg...

  11. Status of the HIRFL–CSR complex

    International Nuclear Information System (INIS)

    Highlights: • HIRFL is in a very positive state and can provide all ion species with maximum energy to 1 GeV/u (A/q = 2). • Present status of HIRFL complex is given as well as the new progress on operation and improvement. • With emphasize on HIRFL–CSR project, main features realized during the commissioning and operation are described in detail. • The progress on physics experiments and hadron cancer therapy are also presented. -- Abstract: The HIRFL–CSR, as an upgrade of the HIRFL, has been put into operation since 2008. Together with a series of improvements of injector cyclotrons, the HIRFL is in a very good state and can provide all ion species from proton to uranium with energy variable from ion source energy to 1 GeV/u (A/q = 2). Present status of the HIRFL–CSR complex is given. Main features realized during the commissioning and operation are described in detail. The progress on physics experiments and cancer therapy are also presented

  12. Novo Nordisk og CSR

    OpenAIRE

    Skar, Lasse Feilberg; Olsen, Isabella Victoria; Palm, Laura Bechstøfft

    2014-01-01

    Abstract This study is a critical case study that concerns itself with the danish firm Novo Nordisk. The study's main focus is on the CSR-strategy of the firm, and furthermore to investigate following key elements; legitimacy, the power of the media and Michael Porter and Mark Kramer’s theory about shared value. The critical approach to Novo Nordisk and it’s strategy is necessary to the study because, it wish to get real insight in the firm’s strategy. To get part of the insight, an i...

  13. HIRFL-CSR physics program

    International Nuclear Information System (INIS)

    The research activities at HIRFL-CSR cover the fields of the radio-biology, material science, atomic physics, and nuclear physics. This talk will mainly concentrate on the program on nuclear physics with the existing and planned experimental setups at HIRFL-CSR. (author)

  14. Cyclotron subharmonics resonant (CSR) heating

    International Nuclear Information System (INIS)

    Corresponding to the experiment done with the JIPPT-II-U device [Phys. Rev. Lett. 54, 2339 (1985)], the cyclotron subharmonics resonant (CSR) heating mechanism is studied using particle simulation codes with an emphasis on the relationship between CSR and the nonlinear Landau damping

  15. CSR-1 Slices a Balance.

    Science.gov (United States)

    Yu, Ruby; Moazed, Danesh

    2016-04-01

    CSR-1 is a germline-expressed C. elegans Argonaute protein essential for viability. In this issue of Cell, Gerson-Gurwitz et al. now demonstrate a role for CSR-1 and its slicer activity in downregulating the levels of maternally deposited mRNAs to fine-tune the expression of proteins with critical roles in embryonic cell divisions. PMID:27058659

  16. Occupational Therapy Use by Older Adults With Cancer

    OpenAIRE

    Pergolotti, Mackenzi; Cutchin, Malcolm P.; Weinberger,Morris; Meyer, Anne-Marie

    2014-01-01

    A retrospective cohort study of 27,131 older adults diagnosed with cancer between 2004 and 2007 found that survivors who used occupational therapy after diagnosis also had the highest levels of comorbidities.

  17. Overview on the HIRFL-CSR facility

    International Nuclear Information System (INIS)

    The status of the HIRFL (Heavy Ion Facility in Lanzhou) – Cooler Storage Ring (CSR) at the IMP is reported. The main physics goals at the HIRFL-CSR are the researches on nuclear structure and decay property, EOS of nuclear matter, hadron physics, highly charged atomic physics, high energy density physics, nuclear astrophysics, and applications for cancer therapy, space industries, materials and biology sciences. The HIRFL-CSR is the first ion cooler-storage-ring system in China, which consists of a main ring (CSRm), an experimental ring (CSRe) and a radioactive beam line (RIBLL2). The two existing cyclotrons SFC (K = 70) and SSC (K = 450) are used as its injectors. The 7 MeV/u 12C6+ ions were stored successfully in CSRm with the stripping injection in January 2006. After that, realized were the accelerations of 12C6+, 36Ar18+, 78Kr28+ and 129Xe27+ ions with energies of 1 GeV/u, 1 GeV/u, 450 MeV/u and 235 MeV/u, respectively, including accumulation, electron cooling and acceleration. In 2008, the first two isochronous mass measurement experiments with the primary beams of 36Ar18+ and 78Kr28+ were performed at CSRe with the Δp/p ~ 10-5. (author)

  18. Overview on the Hirfl-Csr Facility

    Science.gov (United States)

    Xiao, G. Q.; Xia, J. W.; Yuan, Y. J.; Mao, R. S.; Zheng, J. H.; Tu, X. L.; Wang, M.; Huang, W. X.; Xu, H. S.; Zhan, W. L.

    The status of the HIRFL (Heavy Ion Facility in Lanzhou) - Cooler Storage Ring (CSR) at the IMP is reported. The main physics goals at the HIRFL-CSR are the researches on nuclear structure and decay property, EOS of nuclear matter, hadron physics, highly charged atomic physics, high energy density physics, nuclear astrophysics, and applications for cancer therapy, space industries, materials and biology sciences. The HIRFL-CSR is the first ion cooler-storage-ring system in China, which consists of a main ring (CSRm), an experimental ring (CSRe) and a radioactive beam line (RIBLL2). The two existing cyclotrons SFC (K = 70) and SSC (K = 450) are used as its injectors. The 7 MeV/u 12C6+ ions were stored successfully in CSRm with the stripping injection in January 2006. After that, realized were the accelerations of 12C6+, 36Ar18+, 78Kr28+ and 129Xe27+ ions with energies of 1 GeV/u, 1 GeV/u, 450 MeV/u and 235 MeV/u, respectively, including accumulation, electron cooling and acceleration. In 2008, the first two isochronous mass measurement experiments with the primary beams of 36Ar18+ and 78Kr28+ were performed at CSRe with the Δp/p ~ 10-5.

  19. CSR – A MARKETING TOOL?

    OpenAIRE

    MIHALACHE, Silvia-Ştefania

    2011-01-01

    Starting from the idea that investing in CSR creates value not only for the company’s stakeholders, but especially for the company itself, in this article, using secondary data analysis, we try to answer the question: is CSR a sign of responsibility or just a marketing tool for promoting the business?The purpose of this paper is to bring contributions in highlighting the nature of the connection between CSR and Marketing, using the secondary data analyze of the annual reports of some companie...

  20. Integrated reporting with CSR practices

    DEFF Research Database (Denmark)

    Lueg, Klarissa; Lueg, Rainer; Andersen, Karina;

    2016-01-01

    and for controlling CSR implementation. However, the long and technical CSR reports did not effectively communicate EGE’s values and possibilities. We outline how EGE overcame these barriers. Contribution: We suggest that IR implementations depend on the context, and explain why the case company has opted to issue 2...... for CSR after IR became mandatory in Denmark. Methodology: We conduct a case study at the Danish carpet manufacturer EGE. We interpret the case from the perspective of pragmatic constructivism, which focuses on the integration of four dimensions: facts, possibilities, values, and communication. Findings...

  1. CSR in TSL companies

    Directory of Open Access Journals (Sweden)

    Joanna DYCZKOWSKA

    2015-03-01

    Full Text Available TSL companies are characterized by high dynamics of an increase of incomes, and hence increased shipping. Owing to a rational policy in the area of the consolidation of production and distribution, they may boast of a better use of the means of transport. The purpose of this article is to present the activities in the area of the eco-friendly CSR aspect in the activities of TSL companies taking into consideration particularly logistic operators. The research methods used in the study include an analysis of secondary data, observations and comparative analyses. Road transport in the shipping structure comes first and it constitutes 84% of freights. In the year 2009, in Poland greenhouse gas emissions from road transport amounted to 42.5 million tons (4.84% of the EU member states and CO emissions were 41.9 million tons (analogically, 4.83% of environment pollutions in the European Union. This causes an emission of fumes into the atmosphere. The policy of sustainable development pursued by logistic operators under corporate social responsibility is a response to the abovementioned data. They take decisions concerning social and environmental aspects. The activities of TSL companies under CSR need to provide an answer to customer expectations and needs, and they have to cause an increase of competitiveness on the market. The selected four largest logistic operators conduct the following eco-friendly activities on the highest level: fume emission reports and the control of these emissions, transport of hazardous goods (ADR, voluntary services in the scope of environmental protection and cooperation with eco-friendly organizations. There are those activities which call for improvement: a limitation of the emission of fumes, waste management and sewage treatment policy.

  2. Harmonization in CSR reporting: MNEs and global CSR standards

    OpenAIRE

    Fortanier, F.; Kolk, A.; Pinkse, J.

    2011-01-01

    This paper focuses on MNEs’ corporate social responsibility (CSR) reporting, which previous studies have found to exhibit strong country-of-origin effects. It examines whether MNEs’ adherence to global standards (as adopted by e.g. ILO, OECD, UN, ISO) is associated with smaller cross-country differences and less country-of-origin effects in CSR reporting, and whether stringency of standards’ enforcement mechanisms affects reporting harmonization. To test our hypotheses, we collected data on 2...

  3. Primary care for young adult cancer survivors: an international perspective

    DEFF Research Database (Denmark)

    Hølge-Hazelton, Bibi; Blake-Gumbs, Lyla; Miedema, Baujke;

    2010-01-01

    PURPOSE: Internationally, family physicians (FP) are not routinely involved in young adult cancer (YAC) care. In this short report, we would like to make a compelling argument for primary care involvement. METHODS: Comparative descriptions and literature review. RESULTS: Cancer among YAs is rare ...... continuing medical education (CME) initiatives, and an enhanced cooperative effort between those delivering and coordinating cancer care.......PURPOSE: Internationally, family physicians (FP) are not routinely involved in young adult cancer (YAC) care. In this short report, we would like to make a compelling argument for primary care involvement. METHODS: Comparative descriptions and literature review. RESULTS: Cancer among YAs is rare...... and usually not the first thing that comes into the FP's mind. Youth is sometimes mistakenly regarded as a protective factor. Across the countries, almost all YACs are treated in tertiary health care facilities with specialists providing the majority of care. Health care services are covered by the universal...

  4. Breast cancer in adolescent and young adult women.

    Science.gov (United States)

    Gewefel, Hanan; Salhia, Bodour

    2014-12-01

    Breast cancer is one of the most frequently diagnosed malignancy among adolescent and young adult (AYA) women, accounting for approximately 14% of all AYA cancer diagnoses and 7% of all breast cancer. Breast cancer in AYA women is believed to represent a more biologically aggressive disease, but aside from commonly known hereditary predispositions, little is still known about the underlying molecular genetic causes. This review examines the current trends of breast cancer in AYA women as they relate to clinical, social, genetic, and molecular pathologic characteristics. We highlight existing trends, treatment and imaging approaches, and health burdens as they relate to breast cancer in AYA women and provide a discussion on ways to help improve the overall management of this breast cancer cohort. PMID:25034440

  5. CSR in Publicly Owned Enterprises

    DEFF Research Database (Denmark)

    Lauesen, Linne Marie

    2011-01-01

    of the opportunities and barriers in CSR in these publicly owned enterprises (POEs). The research question is: why do the opportunities of CSR in POEs seem more beneficial than for normal private businesses, while the barriers seem to slow the progression? The opportunities lie in the closeness to and willingness......Purpose – CSR in water utilities in Denmark faces various challenges in getting to the same level as in private organisations. The water utilities are newly privatised, hybrid organisations that are both professionally and politically driven. The purpose of this paper is an examination...... of the political decision-makers of the city. The barriers to CSR in POEs stem from the legal regulatory framework, which dictates efficiencies, price and cost reductions and limits the ethical investments of the POEs. Design/methodology/approach – The methodology of the paper is a comparative study and analysis...

  6. Interaction of CSR1 with XIAP Reverses Inhibition of Caspases and Accelerates Cell Death

    OpenAIRE

    Zheng, Zhong-Liang; Tan, Lang-Zhu; Yu, Yan P.; Michalopoulos, George; Luo, Jian-Hua

    2012-01-01

    Cellular Stress Response 1 (CSR1) is a tumor suppressor gene that is located at 8p21, a region that is frequently deleted in prostate cancer as well as a variety of human malignancies. Previous studies have indicated that the expression of CSR1 induces cell death. In this study, we found that CSR1 interacts with X-linked Inhibitor of Apoptosis Protein (XIAP), using yeast two-hybrid screening analyses. XIAP overexpression has been found in many human cancers, and forced expression of XIAP bloc...

  7. Supportive Care in Older Adults with Cancer: Across the Continuum.

    Science.gov (United States)

    Koll, Thuy; Pergolotti, Mackenzi; Holmes, Holly M; Pieters, Huibrie C; van Londen, G J; Marcum, Zachary A; MacKenzie, Amy R; Steer, Christopher B

    2016-08-01

    Supportive care is an essential component of anticancer treatment regardless of age or treatment intent. As the number of older adults with cancer increases, and supportive care strategies enable more patients to undergo treatment, greater numbers of older patients will become cancer survivors. These patients may have lingering adverse effects from treatment and will need continued supportive care interventions. Older adults with cancer benefit from geriatric assessment (GA)-guided supportive care interventions. This can occur at any stage across the cancer treatment continuum. As a GA commonly uncovers issues potentially unrelated to anticancer treatment, it could be argued that the assessment is essentially a supportive care strategy. Key aspects of a GA include identification of comorbidities, assessing for polypharmacy, screening for cognitive impairment and delirium, assessing functional status, and screening for psychosocial issues. Treatment-related issues of particular importance in older adults include recognition of increased bone marrow toxicity, management of nausea and vomiting, identification of anemia, and prevention of neurotoxicity. The role of physical therapy and cancer rehabilitation as a supportive care strategy in older adults is important regardless of treatment stage or intent. PMID:27342609

  8. Identification of a novel regulatory protein (CsrD) that targets the global regulatory RNAs CsrB and CsrC for degradation by RNase E

    OpenAIRE

    Suzuki, Kazushi; Babitzke, Paul; Kushner, Sidney R.; Romeo, Tony

    2006-01-01

    In Escherichia coli, the global regulatory protein CsrA (carbon store regulator A) binds to leader segments of target mRNAs, affecting their translation and stability. CsrA activity is regulated by two noncoding RNAs, CsrB and CsrC, which act by sequestering multiple CsrA dimers. Here, we describe a protein (CsrD) that controls the degradation of CsrB/C RNAs. The dramatic stabilization of CsrB/C RNAs in a csrD mutant altered the expression of CsrA-controlled genes in a manner predicted from t...

  9. Occupational Therapy for Adults With Cancer: Why It Matters.

    Science.gov (United States)

    Pergolotti, Mackenzi; Williams, Grant R; Campbell, Claudine; Munoz, Lauro A; Muss, Hyman B

    2016-03-01

    Adults with cancer may be at risk for limitations in functional status and quality of life (QOL). Occupational therapy is a supportive service with the specific mission to help people functionally engage in life as safely and independently as possible with the primary goal of improving QOL. Unfortunately, for people with cancer, occupational therapy remains underused. The overall purpose of this review is to provide an understanding of what occupational therapy is and its relevance to patients with cancer, highlight the reasons to refer, and, last, provide general advice on how to access services. PMID:26865588

  10. Occupational Therapy for Adults With Cancer: Why It Matters.

    Science.gov (United States)

    Pergolotti, Mackenzi; Williams, Grant R; Campbell, Claudine; Munoz, Lauro A; Muss, Hyman B

    2016-03-01

    Adults with cancer may be at risk for limitations in functional status and quality of life (QOL). Occupational therapy is a supportive service with the specific mission to help people functionally engage in life as safely and independently as possible with the primary goal of improving QOL. Unfortunately, for people with cancer, occupational therapy remains underused. The overall purpose of this review is to provide an understanding of what occupational therapy is and its relevance to patients with cancer, highlight the reasons to refer, and, last, provide general advice on how to access services.

  11. Cancer literacy as a mediator for cancer screening behaviour in Korean adults.

    Science.gov (United States)

    Lee, Hee Yun; Rhee, Taeho Greg; Kim, Nam Keol

    2016-09-01

    This study investigates the cancer literacy level in Korean adults and examines whether cancer literacy plays a mediating role in the relationship between population characteristics and cancer screening behaviours. We collected data from 585 community-dwelling adults in Korea using self-administered surveys and face-to-face interviews from October to December in 2009. Guided by Andersen's behavioural model, we used a structural equation model to estimate the effect of cancer literacy as a mediator and found that cancer literacy mediated cancer screening behaviour. In the individual path analysis models, cancer literacy played a significant mediating role for the use of eastern medicine, fatalism, health status and the number of chronic diseases. When controlling for other relevant covariates, we found that in the optimal path model, cancer literacy played a mediating role in the relationship between the use of eastern medicine and self-rated health status as well as cancer screening behaviour. Thus, developing community-based cancer education programmes and training clinical practitioners in eastern medicine clinics about the importance of informing their patients about regular cancer screening may be an option to boost cancer literacy and screening behaviour in Korea. PMID:25975449

  12. Learning CSR for Sustainable Corporate Advantage

    OpenAIRE

    Kakabadse, Andrew P.; Kakabadse, Nada K.; Linda Lee-Davies

    2014-01-01

    Corporate Social Responsibility (CSR) has become a strategic and operational reality of the business and academic world. Not that the principles of CSR are always respected or that its practice is consistently applied. Bearing in mind the multi-faceted nature of both CSR and the corporate environment, as well as the paradox of what is taught in Higher Education and what is practised within its own walls, this paper provides a learning cyclical pathway to sustainable CSR implementation and pro...

  13. CSR strategie pro firmu Liho Blanice

    OpenAIRE

    Březinová, Ilona

    2012-01-01

    The aim of this thesis is to propose a socially responsible activities, which could a smaller company, like Liho Blanice, deals with and implement them in practice. The theoretical part focuses on the introduction of the concept of CSR, its basic features and principles, as well as the methodology of Standard Responsible Company, and some concepts related to CSR. The next part deals with the application of CSR practices, from initial planning to its measurement. CSR strategies of three global...

  14. Exploring the fit between CSR and innovation

    OpenAIRE

    Steven P. MacGregor; Fontrodona, Joan

    2008-01-01

    An exploration of the fit or space between CSR and innovation is presented, based on the RESPONSE project, a 15-month study involving 60 SMEs throughout Europe. The main practical output of the project was the Social Innovation model, yet a conceptual understanding of CSR and innovation is best advanced through the three hypotheses that constitute the conclusions of the project: H1) The diffusion of CSR should be modelled on the diffusion of innovation; H2) CSR implementation and innovation c...

  15. Epidemiology of cancers among adolescents and young adults from a tertiary cancer center in Delhi

    OpenAIRE

    Randeep Singh; Rashmi Shirali; Sonali Chatterjee; Arun Adhana; Ramandeep Singh Arora

    2016-01-01

    Background and Objectives: Although cancer in adolescents and young adults (AYAs) is increasingly an area of focus, there is a paucity of clinical and epidemiological data from developing countries. Our objective was to analyze the geographical distribution, sex ratio, histology, and disease patterns of cancers in AYA. Materials and Methods: All patients aged 15-29 years with the diagnosis of cancer who were registered with two hospitals in New Delhi during a 12-month period from January 2014...

  16. Towards strategic CSR in the multinational corporations

    DEFF Research Database (Denmark)

    Linneberg, Mai Skjøtt; Thorup-Jensen, Line

    2014-01-01

    CSR is a context-specific phenomenon, which makes working strategically with CSR particularly challenging for multinational corporation as it must allow for the various contexts of operation. Based on the extant literature, this article provides a conceptual presentation of MNC's opportunities...... and a global CSR approach....

  17. CSR:New Engine of Economic Recovery

    Institute of Scientific and Technical Information of China (English)

    Guo Yan

    2010-01-01

    @@ Nowadays, China has more and more focused Corporate Social Responsibility (CSR). From October 2009, more than 600 Chinese companies have released CSR reports. According to statistics from China WTO Tribune, in 2009 China issued a total of 631 CSR reports, 3.73 times more than that released in 2008.

  18. Strategiske CSR partnerskaber - Strategisk anvendelse og intern kommunikativ forankring af CSR partnerskaber i IBM Danmark

    OpenAIRE

    Grimstad, Mie Maja Lütken; Jakobsen, Sofie Damgaard

    2016-01-01

    This thesis examines the strategic use of CSR partnerships and the anchoring in the organization using internal CSR communication. There is a known paradox in communicating CSR externally, since businesses often face distrust from stakeholders. On the basis of the conviction that external CSR communication has to start with an internal anchoring, this master thesis has sought to answer the following thesis statement: how can IBM Denmark strategically work with CSR partnerships and how are the...

  19. Regulatory Interactions of Csr Components: the RNA Binding Protein CsrA Activates csrB Transcription in Escherichia coli

    OpenAIRE

    Gudapaty, Seshagirirao; Suzuki, Kazushi; Wang, Xin; Babitzke, Paul; Romeo, Tony

    2001-01-01

    The global regulator CsrA (carbon storage regulator) of Escherichia coli is a small RNA binding protein that represses various metabolic pathways and processes that are induced in the stationary phase of growth, while it activates certain exponential phase functions. Both repression and activation by CsrA involve posttranscriptional mechanisms, in which CsrA binding to mRNA leads to decreased or increased transcript stability, respectively. CsrA also binds to a small untranslated RNA, CsrB, f...

  20. Harmonization in CSR reporting: MNEs and global CSR standards

    NARCIS (Netherlands)

    F. Fortanier; A. Kolk; J. Pinkse

    2011-01-01

    This paper focuses on MNEs’ corporate social responsibility (CSR) reporting, which previous studies have found to exhibit strong country-of-origin effects. It examines whether MNEs’ adherence to global standards (as adopted by e.g. ILO, OECD, UN, ISO) is associated with smaller cross-country differe

  1. Income in Adult Survivors of Childhood Cancer

    Science.gov (United States)

    Wengenroth, Laura; Sommer, Grit; Schindler, Matthias; Spycher, Ben D.; von der Weid, Nicolas X.; Stutz-Grunder, Eveline; Michel, Gisela; Kuehni, Claudia E.

    2016-01-01

    Introduction Little is known about the impact of childhood cancer on the personal income of survivors. We compared income between survivors and siblings, and determined factors associated with income. Methods As part of the Swiss Childhood Cancer Survivor Study (SCCSS), a questionnaire was sent to survivors, aged ≥18 years, registered in the Swiss Childhood Cancer Registry (SCCR), diagnosed at age 4’500 CHF), even after we adjusted for socio-demographic and educational factors (OR = 0.46, p<0.001). Older age, male sex, personal and parental education, and number of working hours were associated with high income. Survivors of leukemia (OR = 0.40, p<0.001), lymphoma (OR = 0.63, p = 0.040), CNS tumors (OR = 0.22, p<0.001), bone tumors (OR = 0.24, p = 0.003) had a lower income than siblings. Survivors who had cranial irradiation, had a lower income than survivors who had no cranial irradiation (OR = 0.48, p = 0.006). Discussion Even after adjusting for socio-demographic characteristics, education and working hours, survivors of various diagnostic groups have lower incomes than siblings. Further research needs to identify the underlying causes. PMID:27213682

  2. Adult cancer clinical trials that fail to complete: an epidemic?

    Science.gov (United States)

    Stensland, Kristian D; McBride, Russell B; Latif, Asma; Wisnivesky, Juan; Hendricks, Ryan; Roper, Nitin; Boffetta, Paolo; Hall, Simon J; Oh, William K; Galsky, Matthew D

    2014-09-01

    The number and diversity of cancer therapeutics in the pipeline has increased over the past decade due to an enhanced understanding of cancer biology and the identification of novel therapeutic targets. At the same time, the cost of bringing new drugs to market and the regulatory burdens associated with clinical drug development have progressively increased. The finite number of eligible patients and limited financial resources available to evaluate promising new therapeutics represent rate-limiting factors in the effort to translate preclinical discoveries into the next generation of standard therapeutic approaches. Optimal use of resources requires understanding and ultimately addressing inefficiencies in the cancer clinical trials system. Prior analyses have demonstrated that a large proportion of trials initiated by the National Cancer Institute (NCI) Cooperative Group system are never completed. While NCI Cooperative Group trials are important, they represent only a small proportion of all cancer clinical trials performed. Herein, we explore the problem of cancer clinical trials that fail to complete within the broader cancer clinical trials enterprise. Among 7776 phase II-III adult cancer clinical trials initiated between 2005-2011, we found a seven-year cumulative incidence of failure to complete of approximately 20% (95% confidence interval = 18% to 22%). Nearly 48000 patients were enrolled in trials that failed to complete. These trials likely contribute little to the scientific knowledge base, divert resources and patients from answering other critical questions, and represent a barrier to progress.

  3. Vitamin D supplementation for prevention of cancer in adults

    DEFF Research Database (Denmark)

    Bjelakovic, Goran; Gluud, Lise Lotte; Nikolova, Dimitrinka;

    2014-01-01

    BACKGROUND: The evidence on whether vitamin D supplementation is effective in decreasing cancers is contradictory. OBJECTIVES: To assess the beneficial and harmful effects of vitamin D supplementation for prevention of cancer in adults. SEARCH METHODS: We searched the Cochrane Central Register...... vitamin D₃, one trial tested vitamin D₂, and three trials tested calcitriol supplementation. Cancer occurrence was observed in 1927/25,275 (7.6%) recipients of vitamin D versus 1943/25,348 (7.7%) recipients of control interventions (RR 1.00 (95% confidence interval (CI) 0.94 to 1.06); P = 0.88; I² = 0......% relative risk reduction. We did not observe substantial differences in the effect of vitamin D on cancer in subgroup analyses of trials at low risk of bias compared to trials at high risk of bias; of trials with no risk of for-profit bias compared to trials with risk of for-profit bias; of trials assessing...

  4. Cardiovascular Disease in Survivors of Adolescent and Young Adult Cancer

    DEFF Research Database (Denmark)

    Rugbjerg, Kathrine; Mellemkjaer, Lene; Boice, John D;

    2014-01-01

    BACKGROUND: Cardiovascular disease has emerged as a serious late effect in survivors of adolescent and young adult cancer, but risk has not been quantified comprehensively in a population-based setting. METHODS: In the Danish Cancer Registry, we identified 43153 1-year survivors of cancer diagnosed...... at ages 15 to 39 years (1943-2009) and alive in 1977; from the Danish Civil Registration System, we randomly selected a comparison cohort of the same age and sex. Subjects were linked to the Danish Patient Register, and observed numbers of first hospitalizations for cardiovascular disease (International...... Classification of Diseases, Tenth Revision codes I10-I79) were compared with the expected numbers derived from the comparison cohort. We calculated the absolute excess risks attributable to status as a survivor of cancer and standardized hospitalization rate ratios (RRs). All statistical tests were two...

  5. Analysis of Cheminova CSR practice

    DEFF Research Database (Denmark)

    Jørgensen, Michael Søgaard; Milanez, Bruno; Porto, Marcelo Firpo

    This working paper is part of a case study about the international environmental and social performance of the multinational Danish pesticide manufacturing and marketing company Cheminova. In the paper the practice of Cheminova is described and characterised based on its CSR reports from 2007...

  6. Requirements management: A CSR's perspective

    Science.gov (United States)

    Thompson, Joanie

    1991-01-01

    The following subject areas are covered: customer service overview of network service request processing; Customer Service Representative (CSR) responsibility matrix; extract from a sample Memorandum of Understanding; Network Service Request Form and its instructions sample notification of receipt; and requirements management in the NASA Science Internet.

  7. Nasopharyngeal cancer; Cancers du cavum de l'adulte

    Energy Technology Data Exchange (ETDEWEB)

    Fleury, B.; Biston, M.C.; Montbarbon, X.; Pommier, P. [Departement de radiotherapie, Centre de lutte contre le cancer Leon-Berard, 69 - Lyon (France)

    2010-07-01

    The main objective of this work was to propose recommendations concerning the delineation of the target volume of the nasopharyngeal cancers, the planning of the treatment, and describe the expected results about the efficiency and the toxicities. Theses recommendations are based upon anatomy, natural history of theses tumors, and upon published experiences from different teams working with IMRT. (authors)

  8. External CSR Communication in a Strategic Approach

    Directory of Open Access Journals (Sweden)

    Diana Corina GLIGOR-CIMPOIERU

    2014-12-01

    Full Text Available As part of a strategic approach, aimed at assuring mutual benefits for the social cause and the business organization, a good CSR - Corporate Social Responsibility communication is vital for the success of a CSR program. We argue that there is not a problem with the legitimacy of the CSR concept, but rather to its implementation. If a business organization implementing socially responsible initiatives is focusing only on reaping the image benefits from a simple public relations perspective, then it loses all the potential business benefits it could gain from a strategic approach focused on long term real results in a win-win perspective. The fact that the image benefit is one of the most important incentives that a business organization could obtain for engaging in CSR activities cannot be ignored, and that is the reason why we have chosen to analyse the topic of CSR communication, mainly external communication, as an important link in the process of implementing a CSR program, that plays an important part for the success of a CSR program. The approach on CSR communication should definitely be a strategic one, and long already common forms of external CSR communication like web pages or CSR annual reports new means of social media networks have an increasing importance. For the practical part of the paper, we were interested in analyzing how much of the external CSR communication in the Romanian business environment is oriented toward a traditional or a strategic approach.

  9. Estimating cancer risks to adults undergoing body CT examinations

    International Nuclear Information System (INIS)

    The purpose of the study is to estimate cancer risks from the amount of radiation used to perform body computed tomography (CT) examination. The ImPACT CT Patient Dosimetry Calculator was used to compute values of organ doses for adult body CT examinations. The radiation used to perform each examination was quantified by the dose-length product (DLP). Patient organ doses were converted into corresponding age and sex dependent cancer risks using data from BEIR VII. Results are presented for cancer risks per unit DLP and unit effective dose for 11 sensitive organs, as well as estimates of the contribution from 'other organs'. For patients who differ from a standard sized adult, correction factors based on the patient weight and antero-posterior dimension are provided to adjust organ doses and the corresponding risks. At constant incident radiation intensity, for CT examinations that include the chest, risks for females are markedly higher than those for males, whereas for examinations that include the pelvis, risks in males were slightly higher than those in females. In abdominal CT scans, risks for males and female patients are very similar. For abdominal CT scans, increasing the patient age from 20 to 80 resulted in a reduction in patient risks of nearly a factor of 5. The average cancer risk for chest/abdomen/pelvis CT examinations was ∼26 % higher than the cancer risk caused by 'sensitive organs'. Doses and radiation risks in 80 kg adults were ∼10 % lower than those in 70 kg patients. Cancer risks in body CT can be estimated from the examination DLP by accounting for sex, age, as well as patient physical characteristics. (authors)

  10. Recruiting young adult cancer survivors for behavioral research.

    Science.gov (United States)

    Rabin, Carolyn; Horowitz, Santina; Marcus, Bess

    2013-03-01

    Young adults have been dramatically underrepresented in cancer survivorship research. One contributing factor is the difficulty recruiting this population. To identify effective recruitment strategies, the current study assessed the yield of strategies used to recruit young survivors for an exercise intervention including: clinic-based recruitment, recruitment at cancer-related events, mailings, telephone-based recruitment, advertising on the internet, radio, television and social networking media, distributing brochures and word-of-mouth referrals. When taking into account the strategies for which we could track the number of survivors approached, recruitment at an oncology clinic was the most productive: 38 % of those approached were screened and 8 % enrolled. When evaluating which strategy yielded the greatest percentage of the sample, however, mailings were the most productive. Given widespread use of the internet and social networking by young adults, investigators should also consider these low-cost recruitment strategies.

  11. Recruiting young adult cancer survivors for behavioral research.

    Science.gov (United States)

    Rabin, Carolyn; Horowitz, Santina; Marcus, Bess

    2013-03-01

    Young adults have been dramatically underrepresented in cancer survivorship research. One contributing factor is the difficulty recruiting this population. To identify effective recruitment strategies, the current study assessed the yield of strategies used to recruit young survivors for an exercise intervention including: clinic-based recruitment, recruitment at cancer-related events, mailings, telephone-based recruitment, advertising on the internet, radio, television and social networking media, distributing brochures and word-of-mouth referrals. When taking into account the strategies for which we could track the number of survivors approached, recruitment at an oncology clinic was the most productive: 38 % of those approached were screened and 8 % enrolled. When evaluating which strategy yielded the greatest percentage of the sample, however, mailings were the most productive. Given widespread use of the internet and social networking by young adults, investigators should also consider these low-cost recruitment strategies. PMID:22810954

  12. Identification of a Csr system in Serratia marcescens 2170.

    Science.gov (United States)

    Ito, Manabu; Nomura, Kazuki; Sugimoto, Hayuki; Watanabe, Takeshi; Suzuki, Kazushi

    2014-01-01

    The carbon storage regulator (Csr) global regulatory system is conserved in many eubacteria and coordinates the expression of various genes that facilitate adaptation during the major physiological growth phase. The Csr system in Escherichia coli comprises an RNA-binding protein, CsrA; small non-coding RNAs, CsrB and CsrC; and a decay factor for small RNAs, CsrD. In this study, we identified the Csr system in Serratia marcescens 2170. S. marcescens CsrA was 97% identical to E. coli CsrA. CsrB and CsrC RNAs had typical stem-loop structures, including a GGA motif that is the CsrA binding site. CsrD was composed of N-terminal two times transmembrane region and HAMP-like, GGDEF, and EAL domains. Overexpression of S. marcescens csr genes complemented the phenotype of E. coli csr mutants. S. marcescens CsrD affected the decay of CsrB and CsrC RNAs in E. coli. These results suggest that the Csr system in S. marcescens is composed of an RNA-binding protein, two Csr small RNAs, and a decay factor for Csr small RNAs.

  13. Identification of a Csr system in Serratia marcescens 2170.

    Science.gov (United States)

    Ito, Manabu; Nomura, Kazuki; Sugimoto, Hayuki; Watanabe, Takeshi; Suzuki, Kazushi

    2014-01-01

    The carbon storage regulator (Csr) global regulatory system is conserved in many eubacteria and coordinates the expression of various genes that facilitate adaptation during the major physiological growth phase. The Csr system in Escherichia coli comprises an RNA-binding protein, CsrA; small non-coding RNAs, CsrB and CsrC; and a decay factor for small RNAs, CsrD. In this study, we identified the Csr system in Serratia marcescens 2170. S. marcescens CsrA was 97% identical to E. coli CsrA. CsrB and CsrC RNAs had typical stem-loop structures, including a GGA motif that is the CsrA binding site. CsrD was composed of N-terminal two times transmembrane region and HAMP-like, GGDEF, and EAL domains. Overexpression of S. marcescens csr genes complemented the phenotype of E. coli csr mutants. S. marcescens CsrD affected the decay of CsrB and CsrC RNAs in E. coli. These results suggest that the Csr system in S. marcescens is composed of an RNA-binding protein, two Csr small RNAs, and a decay factor for Csr small RNAs. PMID:24859866

  14. Adolescent and young adult cancer: principles of care

    OpenAIRE

    Ramphal, R; Aubin, S.; Czaykowski, P.; Pauw, S; Johnson, A.; McKillop, S.; Szwajcer, D; Wilkins, K; ROGERS, P.

    2016-01-01

    Adolescents and young adults (ayas) with cancer in active treatment face a number of barriers to optimal care. In the present article, we focus on the 3 critical domains of care for ayas—medical, psychosocial, and research—and how changes to the system could overcome barriers. We summarize the current literature, outline recommended principles of care, raise awareness of barriers to optimal care, and suggest specific changes to the system to overcome those barriers in the Canadian context. Ma...

  15. Psychological, social, and behavioral issues for young adults with cancer.

    Science.gov (United States)

    Zebrack, Brad J

    2011-05-15

    Theories of human development suggest that, although all cancer patients experience a common set of life disruptions, they experience them differently, focus on different issues, and attach different levels of importance to different aspects of the experience depending on the time in life at which they were diagnosed. During the critical developmental transition from childhood to adulthood, older adolescents and young adults in particular have typical concerns with establishing identity, developing a positive body image and sexual identity, separating from parents, increasing involvement with peers and dating, and beginning to make decisions about careers or employment, higher education, and/or family. Accordingly, cancer-related issues such as premature confrontation with mortality, changes in physical appearance, increased dependence on parents, disruptions in social life and school/employment because of treatment, loss of reproductive capacity, and health-related concerns about the future may be particularly distressing for adolescents and young adults. Psychosocial and behavioral interventions for young adult cancer patients and survivors often involve assisting these individuals in retaining or returning to function in significant social roles, such as spouse, parent, student, worker, or friend. Successful interventions will enable these young people to overcome the detrimental impact of a health crisis and strengthen the internal and external coping resources available to them. PMID:21523748

  16. Epidemiology of Adolescents and Young Adults with Cancer in Europe.

    Science.gov (United States)

    Desandes, Emmanuel; Stark, Daniel P

    2016-01-01

    To design the services for adolescents and young adults (AYAs) with cancer, we need to understand the patterns of disease and the other clinical and managerial challenges of the patient group. Cancer occurring between the ages of 15 and 39 years is 4 times less rare than cancer occurring during the first 15 years of life and consists of 2% of all invasive cancer in Europe, about 66,000 patients in Europe each year. AYAs have a unique distribution of cancer types, including the peak in incidence of Hodgkin lymphoma (HL) or germ cell tumors. The relative improvement in the survival rate in AYAs has not kept pace with that achieved in younger children, especially for acute leukemia, non-HLs, Ewing tumors and rhabdomyosarcoma. Etiological factors are under-researched and remain largely hypothetical. In this unique group of illnesses, improving AYA cancer management involves bridging interfaces. Since this has begun, outcomes have also begun to improve. The local nature of these interfaces determines the age group considered as AYA. Specific skills are necessary in the clinical, biological and psychosocial domains. Services need support from policy, clinical and administrative professionals. National policy and supranational groups such as SIOPE and ESMO are in constructive collaboration to develop this further. PMID:27595352

  17. CSR Gravity Field Data Products

    Science.gov (United States)

    Bettadpur, Srinivas

    2014-05-01

    The joint NASA/DLR GRACE mission has successfully operated for nearly 12 years, and has provided a remarkable record of global mass flux due to a large variety of geophysical and climate processes at various spatio-temporal scales. The University of Texas Center for Space Research (CSR) hosts the mission PI, and is responsible for delivery of operational (presently denoted as Release-05 or RL05) gravity field data products. In addition, CSR generates and distributes a variety of other gravity field data products, including products generated from the use of satellite laser ranging data. This poster will provide an overview of all these data products, their relative quality, potential applications, and future plans for their development and delivery.

  18. CSR Important to Oil Companies

    Institute of Scientific and Technical Information of China (English)

    2009-01-01

    @@ Corporations are human endeavors, and all human endeavors should benefit our society and reflect our morals. They should provide more than just investor return. The nature of oil industry demands that oil companies be socially responsible in addition to operating in an ethical and environmentally friendly manner. At a time of rising energy prices and global concern over our energy future, however, oil companies should give even greater emphasis to this part of their approach to corporate social responsibility(CSR).

  19. Electron Cooling Experiments in CSR

    CERN Document Server

    Xiaodong, Yang

    2011-01-01

    The six species heavy ion beam was accumulated with the help of electron cooling in the main ring of Cooler Storage Ring of Heavy Ion Research Facility in Lanzhou(HIRFL-CSR), the ion beam accumulation dependence on the parameters of cooler was investigated experimentally. The 400MeV/u 12C6+ and 200MeV/u 129Xe54+ was stored and cooled in the experimental ring CSRe, the cooling force was measured in different condition.

  20. Electron cooling experiments in CSR

    Institute of Scientific and Technical Information of China (English)

    PARKHOMCHUK; Vasily; REVA; Vladimir

    2011-01-01

    The six species heavy ion beam was accumulated with the help of electron cooling in the main ring of Cooler Storage Ring of Heavy Ion Research Facility in Lanzhou (HIRFL-CSR). The ion beam accumulation dependence on the parameters of cooler was investigated experimentally. The 400 MeV/u 12C6+ and 200 MeV/u 129Xe54+ were stored and cooled in the experimental ring CSRe, and the cooling force was measured in different conditions.

  1. Operationalizing CSR through Project Conception

    DEFF Research Database (Denmark)

    Kampf, Constance Elizabeth

    2013-01-01

    The purpose of this paper is to address issues raised about the content of business education—moving away from a business-centered approach to understanding management, opening up a space for reflection, and offering tools to support this change in paradigm. Strand points out these issues as “rel...... of project conception by management can be understood as the place where CSR and sustainability practices can be operationalized in the base unit of work for many corporations—the project....

  2. Conceptions of CSR in management education

    DEFF Research Database (Denmark)

    Lystbæk, Christian Tang

    policy instruments used to promote CSR have been regulation, market-based instruments and voluntary agreements, but in recent years, policies have started to focus on education. Many different actors, such as business schools, businesses and governments, interact in shaping management education...... in management education policies, programs and practices. The aim of this paper is to make a first contribution to a critical analysis of the conceptions of CSR in management education policy. Based on a qualitative deconstructive analysis of management education policies, the paper identifies three main...... conceptions of CSR in management education policy and discusses their implications; a narrow economic conception of CSR, a broader economic conception of CSR and an all-encompassing systemic conception of CSR....

  3. Antagonistic control of the turnover pathway for the global regulatory sRNA CsrB by the CsrA and CsrD proteins.

    Science.gov (United States)

    Vakulskas, Christopher A; Leng, Yuanyuan; Abe, Hazuki; Amaki, Takumi; Okayama, Akihiro; Babitzke, Paul; Suzuki, Kazushi; Romeo, Tony

    2016-09-19

    The widely conserved protein CsrA (carbon storage regulator A) globally regulates bacterial gene expression at the post-transcriptional level. In many species, CsrA activity is governed by untranslated sRNAs, CsrB and CsrC in Escherichia coli, which bind to multiple CsrA dimers, sequestering them from lower affinity mRNA targets. Both the synthesis and turnover of CsrB/C are regulated. Their turnover requires the housekeeping endonuclease RNase E and is activated by the presence of a preferred carbon source via the binding of EIIA(Glc) of the glucose transport system to the GGDEF-EAL domain protein CsrD. We demonstrate that the CsrB 3' segment contains the features necessary for CsrD-mediated decay. RNase E cleavage in an unstructured segment located immediately upstream from the intrinsic terminator is necessary for subsequent degradation to occur. CsrA stabilizes CsrB against RNase E cleavage by binding to two canonical sites adjacent to the necessary cleavage site, while CsrD acts by overcoming CsrA-mediated protection. Our genetic, biochemical and structural studies establish a molecular framework for sRNA turnover by the CsrD-RNase E pathway. We propose that CsrD evolution was driven by the selective advantage of decoupling Csr sRNA decay from CsrA binding, connecting it instead to the availability of a preferred carbon source. PMID:27235416

  4. CRAFTING CORPORATE SOCIAL RESPONSIBILITY (CSR): A CASE STUDY OF CSR STRATEGIZING AND INSTITUTIONALIZATION

    OpenAIRE

    Krikorian, Frederic

    2009-01-01

    This dissertation aims to fill a gap in CSR research by adopting a constructivist perspective to investigate how CSR practitioners craft strategies and how this contributes to the institutionalization of CSR in general, and of the ‘business case for CSR’ in particular. It does so by relying on the strategy-as-practice approach and the notions of institutional entrepreneurship and institutional work. This dissertation is based on a single-case study of two CSR practitioners who implemented a C...

  5. CSR IN MEXICO: SHIFTING FROM PHILANTHROPY TO STRATEGIC CSR IN THE BANKING SECTOR

    OpenAIRE

    Maria Castillo

    2013-01-01

    Developing countries, such as Mexico, have traditionally associated Corporate Social Responsibility (CSR) with philanthropy and have rarely integrated CSR strategies into its core business. However, the 2008 financial crisis has increased public scrutiny of the financial sector practices, leading banks to rethink the way they approach CSR. As part of this new approach to CSR, banks in Mexico are attempting to move away from a solely philanthropic view towards a more strategic implementation t...

  6. The role of CSR and CSR Communication in Finnish natural stone industry

    OpenAIRE

    Palin, Maria

    2015-01-01

    Objective of the Study: The objective of this thesis is to examine Corporate Social Responsibility (CSR) communication in Finnish natural stone companies. Since the majority of the companies are small and medium-sized enterprises (SMEs), the focus is on CSR and CSR communication in the SME context. The study aims to answer the following research questions: (1) How do Finnish natural stone company executives perceive CSR and its role in their business? (2) To what extent do Finnish natural...

  7. Improving the Evidence Base for Treating Older Adults With Cancer: American Society of Clinical Oncology Statement.

    Science.gov (United States)

    Hurria, Arti; Levit, Laura A; Dale, William; Mohile, Supriya G; Muss, Hyman B; Fehrenbacher, Louis; Magnuson, Allison; Lichtman, Stuart M; Bruinooge, Suanna S; Soto-Perez-de-Celis, Enrique; Tew, William P; Postow, Michael A; Cohen, Harvey J

    2015-11-10

    The American Society of Clinical Oncology (ASCO) convened a subcommittee to develop recommendations on improving the evidence base for treating older adults with cancer in response to a critical need identified by the Institute of Medicine. Older adults experience the majority of cancer diagnoses and deaths and make up the majority of cancer survivors. Older adults are also the fastest growing segment of the US population. However, the evidence base for treating this population is sparse, because older adults are underrepresented in clinical trials, and trials designed specifically for older adults are rare. The result is that clinicians have less evidence on how to treat older adults, who represent the majority of patients with cancer. Clinicians and patients are forced to extrapolate from trials conducted in younger, healthier populations when developing treatment plans. This has created a dearth of knowledge regarding the risk of toxicity in the average older patient and about key end points of importance to older adults. ASCO makes five recommendations to improve evidence generation in this population: (1) Use clinical trials to improve the evidence base for treating older adults with cancer, (2) leverage research designs and infrastructure for generating evidence on older adults with cancer, (3) increase US Food and Drug Administration authority to incentivize and require research involving older adults with cancer, (4) increase clinicians' recruitment of older adults with cancer to clinical trials, and (5) use journal policies to improve researchers' reporting on the age distribution and health risk profiles of research participants.

  8. CSR: FOCUS ON EMPLOYEES. ITALIAN CASES.

    Directory of Open Access Journals (Sweden)

    Patrizia Gazzola

    2014-12-01

    Full Text Available The aim of the paper is to analyze the Corporate Social Responsibilitys (CSR influence on employees considering the fact that employees are primary stakeholders who directly contribute to the success of the company. CSR relates to employees helps to motivate the employees themselves. Job quality should be a key objective of any employer because the happy employees can create happy customers, which produce good business results. Research clearly indicates, with the help of statistical data and with the case study methodology, that committing to CSR boosts the morale and commitment of workers in a positive way. Employees who are satisfied with the organization s commitment to social and environmental responsibilities demonstrate more commitment, engagement and productivity. A conceptual framework is proposed based on literature. The author predominantly uses methods of qualitative research. In the research the case study methodology, which has been developed within the social sciences, is used. The paper starts with a concise introduction of CSR. In the first part the potential impact of CSR on employees is explained, considering why CSR may represent a special opportunity to positively influence employees’ and prospective employees’ perceptions of companies. In the second part the research considers three Italian companies that have distinguished themselves for their CSR strategy for employees: Luxottica, Brunello Cucinelli and Ferrero. A growing number of studies have been done regarding the benefits of CSR. However, most are concerned with the external view of shareholders and customer perspective. CSR research on the employee level is not well developed now. In order to better understand its effect on the employees, this study explore the impact of employees' perception of CSR on subsequent work attitudes and behaviors. CSR has a significant effect and it could improve employees' attitudes and behaviors, contribute to corporations' success

  9. Implementasi CSR terhadap Kesejahteraan Hidup Masyarakat

    OpenAIRE

    Andi Mapisangka

    2009-01-01

    Corporate Social Responsibility (CSR) is the firm commitment to the environment in achieving social live welfare. This research aims to analyze the effect of CSR of PT. Batamindo Investment Cakrawala to social live welfare. The indicators of CSR are corporate social responsibility goal, corporate social issues, and corporate relation program. The indicators of welfare live are progress on health, education, and economic activity. Based on ordinary least square, this research concludes: corpor...

  10. The Business Excellence Model for CSR Implementation?

    DEFF Research Database (Denmark)

    Neergaard, Peter; Gjerdrum Pedersen, Esben Rahbek

    2012-01-01

    Most of the Fortune 500 companies address Corporate Social Responsibility (CSR) on their websites. However, CSR remains a fluffy concept difficult to implement in organization. The European Business Excellence Model has since the introduction in 1992 served as a powerful tool for integrating...... European Award winning company has used the model to integrate CSR. The company adapted the Business Excellence model to improve performance, stimulate innovation and consensus....

  11. Progress of HIRFL-CSR Vacuum System

    Institute of Scientific and Technical Information of China (English)

    YangXiaotian; ZhangJunhui; MengJun; ZhangXijun; ZhangXiping; HouShengjun; HuZhenjun; NiuZhiwei; HaoBingan; WuHuimin

    2003-01-01

    The HIRFL-CSR vacuum system progressed steadily during the past year. The 2/3rd of CSR, injection beam line (SSC-CSR, m)'s vacuum chambers were installed in site in Jan. 2003 (Fig.l). The beam diagnostic devices were inserted in the chambers as well. The pressures in unbaked section were kept in 1~5×10-7 Pa range and in baked section were 2~5×10-9 Pa.

  12. Impact of CSR on corporate perfomance

    OpenAIRE

    Pirkl, Jakub

    2014-01-01

    The main goal of this thesis is to introduce the concept of CSR and to describe the impact of socially responsible activities on corporate performance of IBM. The thesis is divided into two parts - theoretical and practical part. The theoretical part is concerned with introducing the concept of CSR, its key principles and studies dealing with the relationship between CSR and corporate performance. The practical part is concerned with introducing IBM's approach to corporate social responsibili...

  13. Taking stock of CSR & SMEs in development

    OpenAIRE

    Jeppesen, Soeren

    2009-01-01

    The international literature on Corporate Social Responsibility (CSR) has focused on large rms, in the North, mostly applying normative, universal and positivist approaches. However, over the last 10-15 years increasing attention has been directed towards micro, small and medium-sized rms, SMEs. While the focus on CSR in SMEs mainly has been con ned to a Northern context, limited, though growing, focus has been on CSR in SMEs in a Southern or developing country context. Th...

  14. CSR Impedance for Non-Ultrarelativistic Beams

    Energy Technology Data Exchange (ETDEWEB)

    Li, Rui [Jefferson Lab., Newport News, VA (United States); Tsai, Cheng Y. [Virginia Polytechnic Inst. and State Univ. (Virginia Tech), Blacksburg, VA (United States); Jefferson Lab., Newport News, VA (United States)

    2015-09-01

    For the analysis of the coherent synchrotron radiation (CSR)-induced microbunching gain in the low energy regime, such as when a high-brightness electron beam is transported through a low-energy merger in an energy-recovery linac (ERL) design, it is necessary to extend the CSR impedance expression in the ultrarelativistic limit to the non-ultrarelativistic regime. This paper presents our analysis of CSR impedance for general beam energies.

  15. CSR INTEGRATION INTO THE CORPORATE STRATEGY

    OpenAIRE

    Patrizia GAZZOLA; Colombo, Gianluca

    2014-01-01

    The aim of this research paper is to develop a model for the integration of ethics and Corporate Social Responsibility (CSR) into the company strategy as a source of competitive advantages. CSR is an organization's obligation to consider the interests of their customers, employees, shareholders, communities and to consider the social and environmental consequences of their business activities. By integrating CSR into the corporate strategy and stakeholder management, organizations can ensure ...

  16. CSR strategie v letectví

    OpenAIRE

    Foralová, Jitka

    2009-01-01

    This thesis deals with the general concept of Corporate Social Resonsibility (CSR), its principles and contributions which have been applied to the air transport market. The first chapter defines the notion of CSR, analyzes three pillars of sustainable development and discusses the opinions that fundamentally reject the CSR concept. The second and the third chapter look at the aviation industry from the sustainable development point of view. Discussion about social contributions of the air tr...

  17. External CSR Communication in a Strategic Approach

    OpenAIRE

    Diana Corina GLIGOR-CIMPOIERU; Valentin Partenie MUNTEANU

    2014-01-01

    As part of a strategic approach, aimed at assuring mutual benefits for the social cause and the business organization, a good CSR - Corporate Social Responsibility communication is vital for the success of a CSR program. We argue that there is not a problem with the legitimacy of the CSR concept, but rather to its implementation. If a business organization implementing socially responsible initiatives is focusing only on reaping the image benefits from a simple public relations perspective, ...

  18. Current lifestyle of young adults treated for cancer in childhood.

    Science.gov (United States)

    Evans, S E; Radford, M

    1995-05-01

    The aim of this study was to look at the current lifestyle of young adult survivors of childhood cancer between the ages of 16 and 30 years to document their achievements and expose any psychosocial problems. Sixty six young adult survivors were contacted and asked if they and their siblings (16-30 years) would take part in a lifestyle study; 48 patients and 38 sibling controls were interviewed. This took the form of a structured lifestyle questionnaire, a self esteem questionnaire (Oxford Psychologists Press), and an unstructured interview. Fifty five per cent of patients achieved five or more A-C grades at 'O' level/GCSE compared with 62% of siblings and a national average of 30%. Despite that these patients were significantly less likely to go on to higher education than their siblings. The two groups were equally employable and earning similar salaries. There were three cases of known employer prejudice. A slightly higher percentage of patients than siblings had their driving licence. Seventeen patients felt their appearance had changed and eight felt that they had a residual physical mobility problem. Both groups were socially active and equally likely to partake in competitive sports. There was no overall difference in the self esteem of the two groups. In general the survivors of childhood cancer were coping well in their young adult life and achieving the same lifestyle goals as their siblings. However, significant problems have been identified. PMID:7618909

  19. CSR ve vybrané společnosti

    OpenAIRE

    Mejdrová, Aneta

    2012-01-01

    The objective of this dissertation is appraisal of the current status of Accenture's CSR initiatives. The theoretical part provides information that is essential for understanding CSR concept; it defines business ethics, a stakeholder theory and the triple bottom line of CSR. Furthermore, it provides a comprehensive view of the history and evolution of CSR and presents possibilities of measuring of CSR. Practical part is focused on Accenture's local and global CSR activities which are evaluat...

  20. Palliative care for adolescents and young adults with cancer

    Directory of Open Access Journals (Sweden)

    Rosenberg AR

    2013-03-01

    Full Text Available Abby R Rosenberg,1–3 Joanne Wolfe4–61Division of Pediatric Hematology/Oncology, Seattle Children’s Hospital, Seattle, WA; 2Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA; 3Department of Pediatrics, University of Washington, Seattle, WA; 4Department of Psychosocial Oncology and Palliative Care/Division of Pediatric Palliative Care, Dana-Farber Cancer Institute, Boston, MA; 5Department of Medicine/Division of Hematology/Oncology, Boston Children’s Hospital, Boston, MA; 6Department of Pediatrics, Harvard University School of Medicine, Boston, MA, USAAbstract: Adolescents and young adults (AYAs with cancer represent a unique and challenging group of patients with distinct developmental and psychosocial needs that may be unrecognized or unmet during their cancer experience. Palliative care refers to the total care of a patient, regardless of his or her disease status, and aims to improve quality of life by controlling symptoms and alleviating physical, social, psychological, and spiritual suffering. Integrating palliative care into standard oncology practice for AYAs is therefore valuable, if not imperative, in improving their overall cancer experience. In this review, we aimed to describe the scope, benefits, and challenges of palliative care for AYA oncology patients. We provide a broad impression of the existing literature describing or investigating palliative care in this population. Put together, the evidence suggests that palliative care is not only needed, but can also be critically beneficial to patients, families, and health care professionals alike. As we increase public and professional awareness of the needs and applications of palliative care for AYA patients with cancer, we will ultimately enable better psychosocial outcomes of the AYA patients and their larger communities.Keywords: supportive care, end of life, psychosocial outcomes, psychosocial oncology, psychosocial needs, quality of life

  1. CSR in Indonesia : a qualitative study from a managerial perspective regarding views and other important aspects of CSR in Indonesia

    OpenAIRE

    Lindgren, Fredrik; Hendeberg, Simon

    2009-01-01

    This paper will from a managerial perspective investigate the function of CSR (Corporate Social Responsibility) as a strategic tool for companies operating in Indonesia.Another aspect this paper will discuss is different views on CSR and what positive aswell as negative aspects CSR brings. The country was first in the world to state a lawregarding CSR performance in 2007, which makes CSR mandatory for all companiesusing natural resources in some way. This issue complicates CSR matters in Indo...

  2. Epidemiology of cancers among adolescents and young adults from a tertiary cancer center in Delhi

    Directory of Open Access Journals (Sweden)

    Randeep Singh

    2016-01-01

    Full Text Available Background and Objectives: Although cancer in adolescents and young adults (AYAs is increasingly an area of focus, there is a paucity of clinical and epidemiological data from developing countries. Our objective was to analyze the geographical distribution, sex ratio, histology, and disease patterns of cancers in AYA. Materials and Methods: All patients aged 15-29 years with the diagnosis of cancer who were registered with two hospitals in New Delhi during a 12-month period from January 2014 to December 2014 were included. Basic demographic information on age, sex, location of stay, and nationality was available. Using cancer site and morphology codes, the cancers were grouped by the Birch classification of AYA cancers. Clinical information on disease and treatment status, was retrospectively studied. Results: There were 287 patients (57.5% male, 85.4% Indian origin registered with 54 (18.8%, 97 (33.8%, and 136 (47.4% patients in the 15-19, 20-24, and 25-29 years age groups, respectively. The three most common cancer groups were carcinomas (40.8%, lymphomas (12.9%, and leukemias (10.4%. The three most common sites in carcinomas were gastrointestinal tract (GIT, genitourinary tract, and breast. The most prevalent cancers in younger AYA (15-19 years were leukemias, lymphomas, central nervous system neoplasms, and in contrast, older AYA (25-29 years suffered mainly from GIT Carcinomas, lymphomas. The leading cancers were breast and GIT carcinomas in females and lymphomas and GIT carcinomas in males. Conclusion: The occurrence of cancer in AYA in India has been described. The distribution differs from the only previous report from India as well as the US Surveillance Epidemiology and End Results database, which can be attributed to a referral bias along with the factual difference in cancer etiology and genetics.

  3. China’s CSR Has Both Common and Unique Dimensions as Compared with Western CSR

    Institute of Scientific and Technical Information of China (English)

    徐尚昆; 杨汝岱

    2008-01-01

    We conducted an inductive analysis of corporate social responsibility (CSR) in China based on an open-ended survey of 630 CEOs and business owners in 12 provinces and municipalities across China. In the survey, we collected 2811 CSR sample scenarios. After examining the quantitative data thus acquired, we identified 9 dimensions of CSR, including two dimensions never mentioned in western literature and another 2 dimensions generally recognized in western countries but not yet taking shape in China. A comparative study of CSR between China and western countries also unveiled some unique dimensions of CSR in China.In conclusion, CSR has been manifested in China in a form different from that in western countries, and China’s CSR is closely related to the social and cultural background of China.

  4. Political CSR in an SME Perspective

    OpenAIRE

    Jeppesen, Søren; Morsing, Mette

    2013-01-01

    We engage a discussion of political CSR in SMEs in an African context. Based on critical observations on Western MNC action in emerging economies, political economists have argued that business profit far more than society from CSR. In this paper we argue that the imperative for growth in developing economies provide an option to con...

  5. Integral Measurement of Dipole Prototype of CSR

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    The dipole prototype is C type used as bending magnet of the injection beam line in CSR, and acts as a model of the dipoles in the CSR main ring simultaneously. The designed relative uniformity of good field is 0.001 in 100 mm width. The results of the local distribution and transfunction at transverse profile measured

  6. CSR INTEGRATION INTO THE CORPORATE STRATEGY

    Directory of Open Access Journals (Sweden)

    Patrizia GAZZOLA

    2014-12-01

    Full Text Available The aim of this research paper is to develop a model for the integration of ethics and Corporate Social Responsibility (CSR into the company strategy as a source of competitive advantages. CSR is an organization's obligation to consider the interests of their customers, employees, shareholders, communities and to consider the social and environmental consequences of their business activities. By integrating CSR into the corporate strategy and stakeholder management, organizations can ensure that the increasing of shareholder value doesn’t overshadow the need to behave ethically to their stakeholders. The research is based on the theoretical framework that supports a thesis of beneficial impact of the development and implementation of CSR plan: by planning out CSR as part of a corporate strategy, companies can achieve the ultimate goal of creating both social value and corporate value.

  7. The Business Excellence Model for CSR Implementation?

    Directory of Open Access Journals (Sweden)

    Neergaard Peter

    2014-11-01

    Full Text Available Most of the Fortune 500 companies address Corporate Social Responsibility (CSR on their websites. However, CSR remains a fluffy concept difficult to implement in organization. The European Business Excellence Model has since the introduction in 1992 served as a powerful tool for integrating quality in organizations. CSR was first introduced in the model in 2002. From 2004 the European Foundation for Quality Management (EFQM has been eager to promote the model as an effective tool for implementing CSR.. The article discusses the potentials of the model for this end and illustrates how a 2006 European Award winning company has used the model to integrate CSR. The company adapted the Business Excellence model to improve performance, stimulate innovation and consensus.

  8. Stakeholder involvement in CSR strategy-making?

    DEFF Research Database (Denmark)

    Trapp, Leila

    2014-01-01

    A given characteristic of successful corporate social responsibility (CSR) programs is that they reflect stakeholder expectations and preferences for corporate behavior. This study examines the process by which this alignment is sought by CSR managers in the CSR strategy-making process. Through...... reliance on stakeholder management theories, and with a particular focus on how and why managers communicate with stakeholders, the extent to which the company-stakeholder alignment process in CSR strategy-making reflects modern, enlightened approaches to stakeholder relations is assessed. This assessment...... is based on an analysis of structured, in-depth interviews with CSR managers from sixteen industry-leading, Danish companies. The managers’ descriptions of their interactions with stakeholders reveal that their practices fall short of the normative, theoretical ideals since their focus is primarily on just...

  9. Impact of IACS Harmonized CSR on Tankers

    Institute of Scientific and Technical Information of China (English)

    郑文青; 吴嘉蒙; 刘寅华; 顾俊

    2014-01-01

    The external draft of Harmonized Common Structural Rules (CSR-H) for Bulk Carriers and Oil Tankers has been released for external review. Based on a consistent methodology at the adoption of the current CSR, CSR-H aims to be in compliance with the IMO GBS where GBS functional requirements fall within the scope, and the safety level is equivalent to or higher than the current CSR criteria. In this paper, by consequence assessment on a 320k VLCC, a 163k Suezmax tanker, a 115k Aframax tanker, a 76k Panamax tanker and a 48k MR tanker, the results of the comparison on the structural scantlings to CSR, the evaluation on the increasing of steel weight and some critical technique issues are discussed.

  10. Reflexive regulation of CSR to promote sustainability

    DEFF Research Database (Denmark)

    Buhmann, Karin

    2011-01-01

    and the EU CSR Alliance. Focusing on human rights based in international law, it analyses the patterns of negotiation in the MSF and the background for the launch of the CSR Alliance. It shows that analysing public-private regulation of CSR from the perspective of reflexive law theory assists us...... in understanding the mechanisms by which public authorities seek to influence firm’s behaviour through CSR in order to promote public policy objectives. The analysis indicates that to be effective, reflexive regulatory approaches to public-private regulation should pay careful attention to procedural design...... in order to balance power disparities among participants. Finally, the analysis suggests that a juridification of CSR is taking place. This development is welcome because legal theory and scholarship’s insight into institutionalisation of norms of conduct has much to offer to society’s interests...

  11. Reflexive regulation of CSR to promote sustainablility

    DEFF Research Database (Denmark)

    Buhmann, Karin

    and the EU CSR Alliance. Focusing on human rights based in international law, it analyses the patterns of negotiation in the MSF and the background for the launch of the CSR Alliance. It shows that analysing public-private regulation of CSR from the perspective of reflexive law theory assists us...... in understanding the mechanisms by which public authorities seek to influence firm’s behaviour through CSR in order to promote public policy objectives. The analysis indicates that to be effective, reflexive regulatory approaches to public-private regulation should pay careful attention to procedural design...... in order to balance power disparities among participants. Finally, the analysis suggests that a juridification of CSR is taking place. This development is welcome because legal theory and scholarship’s insight into institutionalisation of norms of conduct has much to offer to society’s interests...

  12. The Cultural and Rhetorical Parameters of CSR

    DEFF Research Database (Denmark)

    Kampf, Constance

    -construction of CSR discourse through interaction and power relations between "civil society actors" and "the more powerful corporate voices."   In incorporating the cultural systems approach to CSR (Kampf 2007) with Burchell and Cook's argument of a two-way process, government can also be included as part...... of these situated interactions, rhetorical tools such as Brockreide's rhetorical dimension of attitude (1996) and Burke's notions of terministic screens and entitlement (1966) offer a means of demonstrating how language used to describe CSR is co-constructed in a cultural system in which businesses are situated......, but not focal.   De-centering business in the understanding of CSR on the Internet offers potential for analyzing CSR discourse as a dynamic system of ideas visible on the Internet, which allows multiple voices and inhibits traditional gatekeepers. Comparing both the cultural systems of the U.S. and Denmark...

  13. Registration and classification of adolescent and young adult cancer cases.

    Science.gov (United States)

    Pollock, Brad H; Birch, Jillian M

    2008-05-01

    Cancer registries are an important research resource that facilitate the study of etiology, tumor biology, patterns of delayed diagnosis and health planning needs. When outcome data are included, registries can track secular changes in survival related to improvements in early detection or treatment. The surveillance, epidemiology, and end results (SEER) registry has been used to identify major gaps in survival for older adolescent and young adult (AYA) patients compared with younger children and older adults. In order to determine the reasons for this gap, the complete registration and accurate classification of AYA malignancies is necessary. There are inconsistencies in defining the age limits for AYAs although the Adolescent and Young Adult Oncology Progress Review Group proposed a definition of ages 15 through 39 years. The central registration and classification issues for AYAs are case-finding, defining common data elements (CDE) collected across different registries and the diagnostic classification of these malignancies. Goals to achieve by 2010 include extending and validating current diagnostic classification schemes and expanding the CDE to support AYA oncology research, including the collection of tracking information to assess long-term outcomes. These efforts will advance preventive, etiologic, therapeutic, and health services-related research for this understudied age group.

  14. Epoetin and Darbepoetin Treatment for Adults with Cancer

    Science.gov (United States)

    ... Health Disparities and Cancer For Patient Advocates Public Policy Advocacy Cancer Awareness Dates Survivorship Blog About Us You ... Health Disparities and Cancer For Patient Advocates Public Policy Advocacy Cancer Awareness Dates Cancer.Net provides timely, comprehensive, ...

  15. Survivorship care for older adults with cancer: U13 conference report.

    Science.gov (United States)

    Guerard, Emily J; Nightingale, Ginah; Bellizzi, Keith; Burhenn, Peggy; Rosko, Ashley; Artz, Andrew S; Korc-Grodzicki, Beatriz; Canin, Beverly; Dale, William; Ferrell, Betty

    2016-07-01

    Older adult cancer survivors currently account for almost 60% of all cancer survivors. The number of older cancer survivors will continue to increase as the population ages and as patients' live longer after a cancer diagnosis. As part of cancer center accreditation, the American College of Surgeons Commission on Cancer® (CoC) has placed great importance on survivorship care planning. While the CoC has set standards for general survivorship care, there is sparse evidence on how to best care for older adult cancer survivors. Concern exists among the medical community that survivorship care plans could increase paperwork without improving outcomes. Given the diverse and unique needs of older adult cancer survivors, the inter-professional team provides a structure and process for survivorship care built around the particular needs of older adults. The Cancer and Aging Research Group (CARG), in partnership with the NIA/NCI, held a U13 conference in May 2015 in part to discuss survivorship care for older adults with cancer. This report discusses four themes that emerged from one section of the conference: (1) survivorship care is a process that continually evolves to meet the needs of older adults; (2) older adult cancer survivors have unique needs and care plans should be tailored to meet these needs; (3) the inter-professional team is ideally suited to structure survivorship care of older adults; (4) patient advocacy must be encouraged throughout the cancer care continuum. As evidence based survivorship practices develop, the unique needs of older adults need to be given substantial attention.

  16. The Clinician's Toolbox: Assessing the Sexual Impacts of Cancer on Adolescents and Young Adults with Cancer (AYAC

    Directory of Open Access Journals (Sweden)

    Sylvie Aubin, PhD

    2015-09-01

    Conclusion: Cancer can have a significant impact on numerous domains of AYAC sexuality. The assessment of and attention to the impact of sexuality on AYAC is crucial in order to provide effective and comprehensive quality patient cancer care. Aubin S and Perez S. The clinician's toolbox: assessing the sexual impacts of cancer on adolescents and young adults with cancer (AYAC. Sex Med 2015;3:198–212.

  17. Breaking through the self-fulfilling prophecy of CSR

    NARCIS (Netherlands)

    Nijhof, A.H.J.; Zwart, van der A.; Jonker, J.

    2009-01-01

    Since the last decades of the twentieth century the debate on the concept of corporate social responsibility (CSR) intensified significantly. This debate concentrates on the meaning, impact and possible gains from CSR. Alongside the growing number of CSR advocates there are also a number of CSR crit

  18. Empirical Analysis on CSR Communication in Romania: Transparency and Participation

    Directory of Open Access Journals (Sweden)

    Irina-Eugenia Iamandi

    2012-12-01

    Full Text Available In the specific field of corporate social responsibility (CSR, the participation of companies in supporting social and environmental issues is mainly analysed and/or measured based on their CSR communication policy; in this way, the transparency of the CSR reporting procedures is one of the most precise challenges for researchers and practitioners in the field. The main research objective of the present paper is to distinguish between different types of CSR participation by identifying the reasons behind CSR communication for a series of companies acting on the Romanian market. The descriptive analysis – conducted both at integrated and corporate level for the Romanian companies – took into account five main CSR communication related issues: CSR site, CSR report, CSR listing, CSR budget and CSR survey. The results highlight both the declarative/prescriptive and practical/descriptive perspectives of CSR communication in Romania, showing that the Romanian CSR market is reaching its full maturity. In more specific terms, the majority of the investigated companies are already using different types of CSR participation, marking the transition from CSR just for commercial purposes to CSR for long-term strategic use. The achieved results are broadly analysed in the paper and specific conclusions are emphasized.

  19. Incorporating Geriatric Medicine Providers into the Care of the Older Adult with Cancer.

    Science.gov (United States)

    Magnuson, Allison; Canin, Beverly; van Londen, G J; Edwards, Beatrice; Bakalarski, Pamela; Parker, Ira

    2016-11-01

    A significant proportion of cancer patients and survivors are age 65 and over. Older adults with cancer often have more complex medical and social needs than their younger counterparts. Geriatric medicine providers (GMPs) such as geriatricians, geriatric-trained advanced practice providers, and geriatric certified registered nurses have expertise in caring for older adults, managing complex medical situations, and optimizing function and independence for this population. GMPs are not routinely incorporated into cancer care for older adults; however, their particular skill set may add benefit at many points along the cancer care continuum. In this article, we review the role of geriatric assessment in the care of older cancer patients, highlight specific case scenarios in which GMPs may offer additional understanding and insight in the care of older adults with cancer, and discuss specific mechanisms for incorporating GMPs into oncology care. PMID:27613166

  20. Industrial Clusters and CSR in Developing Countries

    DEFF Research Database (Denmark)

    Fayyaz, Anjum; Lund-Thomsen, Peter; Lindgreen, Adam

    2015-01-01

    This article contributes to literature on corporate social responsibility (CSR) exhibited by industrial clusters in developing countries. The authors conceptualize and empirically investigate the role of donor-funded CSR initiatives aimed at promoting collective action by cluster-based small- and......, tensions within SME networks, and negative perceptions of CSR by the cluster-based SMEs themselves. The findings and implications of this analysis can inform both research and policy making in this area......This article contributes to literature on corporate social responsibility (CSR) exhibited by industrial clusters in developing countries. The authors conceptualize and empirically investigate the role of donor-funded CSR initiatives aimed at promoting collective action by cluster-based small......- and medium-sized enterprises (SMEs). A case study of the Sialkot football-manufacturing cluster in Pakistan indicates that donor-funded support of CSR initiatives in industrial clusters in developing countries may be short-lived, due to the political economy of aid, the national context of CSR implementation...

  1. Practices of healthcare professionals from the perspective of older adults living with cancer

    OpenAIRE

    Lucimara Sonaglio Rocha; Margrid Beuter; Eliane Tatsch Neves; Juliane Elis Both; Miriam da Silveira Perrando; Larissa Venturini

    2016-01-01

    Objective: understanding the care practices of health professionals caring for older adults living with cancer in outpatient treatment. Methods: a qualitative research conducted in a hematology oncology outpatient clinic in southern Brazil. A semi-structured interview was conducted with 15 older adults. Data were submitted to thematic analysis. Results: a category of care practice of health professionals amongst older adults living with cancer emerged with two subcategories: disclosure of the...

  2. Circuitry Linking the Csr and Stringent Response Global Regulatory Systems

    OpenAIRE

    Edwards, Adrianne N; Patterson-Fortin, Laura M.; Christopher A Vakulskas; Mercante, Jeffrey W.; Potrykus, Katarzyna; Vinella, Daniel; Camacho, Martha I.; Fields, Joshua A.; Thompson, Stuart A.; Georgellis, Dimitris; Cashel, Michael; Babitzke, Paul; Romeo, Tony

    2011-01-01

    CsrA protein regulates important cellular processes by binding to target mRNAs and altering their translation and/or stability. In Escherichia coli, CsrA binds to sRNAs, CsrB and CsrC, which sequester CsrA and antagonize its activity. Here, mRNAs for relA, spoT and dksA of the stringent response system were found among 721 different transcripts that copurified with CsrA. Many of the transcripts that copurified with CsrA were previously determined to respond to ppGpp and/or DksA. We examined m...

  3. Update on the Management of Pancreatic Cancer in Older Adults.

    Science.gov (United States)

    Lee, Shin Yin; Sissoko, Moussa; Hartshorn, Kevan L

    2016-10-01

    Pancreatic cancer is more common in older adults, who are underrepresented in clinical trials and frequently under treated. Chronological age alone should not deter clinicians from offering treatment to geriatric patients, as they are a heterogeneous population. Geriatric assessment, frailty assessment tools, and toxicity risk scores help clinicians select appropriate patients for therapy. For resectable disease, surgery can be safe but should be done at a high-volume center. Adjuvant therapy is important; though there remains controversy on the role of radiation, chemotherapy is well studied and efficacious. In locally advanced unresectable disease, chemoradiation or chemotherapy alone is an option. Neoadjuvant therapy improves the chances of resectability in borderline resectable disease. Chemotherapy extends survival in metastatic disease, but treatment goals and risk-benefit ratios have to be clarified. Adequate symptom management and supportive care are important. There are now many new treatment strategies and novel therapies for this disease. PMID:27492426

  4. Prospective study of falls and risk factors for falls in adults with advanced cancer.

    LENUS (Irish Health Repository)

    Stone, Carol A

    2012-06-10

    Retrospective studies of inpatients with cancer suggest that a cancer diagnosis confers a high risk of falls. In adults with advanced cancer, we aimed to prospectively document the incidence of falls, identify the risk factors, and determine if falls in this population occur predominantly in older patients.

  5. Turning CSR on it's head

    DEFF Research Database (Denmark)

    Kampf, Constance Elizabeth

    , rather than impermeable boundaries. Thus, social and mobile media can be approached as a force that works at further eroding boundaries between the firm and technology empowered individuals equipped with their personal agendas and social media capital. As an example of social media turning tradition...... their ecological footprint. Then CarrotMob members use social media to recruit as many customers as possible to shop at that time, thus increasing both profits and available resources for the business to engage in sustainability. As sustainability and CSR are enacted differently in the US and EU (Matten and Moon....... However, from a technology perspective, Howe (2009) argues that the boundaries of the firm are becoming porous, and through social media people are contributing some of their best energy for free. These technology empowered stakeholders can be resources for strategy when the firm is seen as having porous...

  6. THE IMPORTANCE OF CSR IMPLEMENTATION

    Directory of Open Access Journals (Sweden)

    Anna Križanová

    2016-09-01

    Full Text Available The last three decades of the twentieth century and the beginning of the twenty-first century were marked by the expansion of managerial ethics and social responsibility of business. Business ceased to be perceived in terms of profit being the sole interest of management, and ethical aspects were stressed more so in connection with the company’s management. Specific managerial ethical initiatives and activities leading from outside and inside the organization constitutes the concept of Corporate Social Responsibility (CSR, which comprises many factors. The aim of this paper is to summarize the positive impact of corporate social responsibility for business activities using secondary data from global surveys and then confirm the importance and benefits of corporate social responsibility for enterprises in the Slovak Republic using primary data.

  7. Mitarbeiterrekrutierung und -bindung durch CSR: Erkenntnisse aus sechs Fallstudien

    OpenAIRE

    Pelzeter, Andrea; Bustamante, Silke; Deckmann, Andreas; Ehlscheidt, Rudi; Freudenberger, Franziska

    2015-01-01

    Im Rahmen des Forschungsprojektes MitCSR wurden sechs Fallstudien ausgearbeitet, die der Frage nachgingen, welche Wirkung Corporate Social Responsibility auf die Rekrutierung und Bindung von Mitarbeitern hat. Für die Erhebung der Wirkung wurden die Einflussfaktoren CSR-Performanz und CSR-Kommunikation von der abhängigen Variable CSR-Wahrnehmung unterschieden (CSR-Trias). In fragebogengestützten Interviews wurde die Perspektive der Unternehmensleitung sowie der bestehenden Mitarbeiter erhoben....

  8. From philanthropy to strategy? An assessment of Indian CSR.

    OpenAIRE

    Træsborg, Emilie Levin

    2014-01-01

    This thesis examines how the Indian CSR-approach conforms to the global strategic CSR-trend. To conduct the study, main characteristics of strategic CSR has been identified through institutional theory as corporations, and their responsible behavior, is a dominant institution in todays globalized society. Furthermore, the traditional characteristics of Indian corporate philanthropy have been identified in order to comprehend if the Indian CSR-approach conforms to global strategic CSR in a dis...

  9. The political economy of corporate social responsibility (CSR)

    OpenAIRE

    2012-01-01

    This dissertation aims to contribute to a more contextually informed analysis of CSR by studying how political-economic institutions influence CSR practices. Approaching CSR as a political phenomenon, the dissertation studies quantitatively whether political-economic institutions can explain variation in CSR practices across 20 advanced capitalist countries, as cross-national variation provides a key to understand the institutional foundations of CSR. However, the dissertation also seeks to p...

  10. How can CSR affect company performance? : A qualitative study of CSR and its effects

    OpenAIRE

    Classon, Johan; Dahlström, Johan

    2006-01-01

    In today’s society, there is a growing interest in, and demand for Corporate Social Responsibility (CSR). Reasons for this can be multinational corporations’ increasing influence on world economy as well as scandals revealing horrible working conditions in different industries. In spite of the fact that the demand for CSR is growing, there has always been critics. The most influential critic is Noble Prize winner Milton Friedman, who claims CSR to be a waste of stockholders’ money. However, s...

  11. CSR: friend or foe? Framing NGO Strategy through CSR in the Pursuit of Sustainable Funding

    OpenAIRE

    Singleton, Sarah

    2006-01-01

    Through the application of frame analysis, corporate social responsibility (CSR) can currently be envisaged in relation to two extreme frames in analysing CSR as an interface for business-NGO collaborations: an altruistic frame (involving short-term, philanthropic business gestures towards NGOs) and a strategic frame (involving long-term, strategic relations between business and NGOs). It is proposed that businesses align with a strategic CSR frame (the business case) and as a consequence of ...

  12. CSR Beyond Borders : A Qualitative Study of International Companies' CSR Adjustment in Dubai

    OpenAIRE

    2013-01-01

    The concept of Corporate Social Responsibility (CSR) receives increasing global attention in academia, the business world and international civil society. This master thesis aims to examine the global spread of CSR across territorial and cultural borders. The globalization literature describes diffusion of ideas as a reason why and how this spread takes place, this thesis uses this theoretical framework to examine how the Western concept of CSR reacts with local environments. The thesis ...

  13. How to motivate managers for CSR?: commitment to CSR by transformational leadership in meetings

    OpenAIRE

    Wabitsch, Vanessa Vivian

    2014-01-01

    Dissertation submitted as partial requirement for the conferral of Master in Marketing / JEL Justification System: M10 – General; M14 – Corporate Culture; Social Responsibility. Purpose: The aim of this research is to examine how it is possible to continuously motivate managers from different departments for Corporate Social Responsibility (CSR). The goal is to investigate if and how CSR leaders can realize commitment to CSR by conducting meetings in transformational leaders...

  14. Regulatory Circuitry of the CsrA/CsrB and BarA/UvrY Systems of Escherichia coli

    OpenAIRE

    Suzuki, Kazushi; Wang, Xin; Weilbacher, Thomas; Pernestig, Anna-Karin; Melefors, Öjar; Georgellis, Dimitris; Babitzke, Paul; Romeo, Tony

    2002-01-01

    The global regulator CsrA (carbon storage regulator) is an RNA binding protein that coordinates central carbon metabolism, activates flagellum biosynthesis and motility, and represses biofilm formation in Escherichia coli. CsrA activity is antagonized by the untranslated RNA CsrB, to which it binds and forms a globular ribonucleoprotein complex. CsrA indirectly activates csrB transcription, in an apparent autoregulatory mechanism. In the present study, we elucidate the intermediate regulatory...

  15. Study of matching between HIRFL and CSR

    International Nuclear Information System (INIS)

    'HIRFL-CSR Cooler Storage Ring' makes use of existing HIRFL as its pre-accelerator. In order to take the full capability of HIRFL, the authors have studied in detailed the matching modes between HIRFL and CSR. It is proposed to use two matching modes; direct matching between SFC (HIRFL injector cyclotron) and CSRm (CSR main ring); three-cascade matching of SFC, SSC (HIRFL main cyclotron) and CSRm. With these combinations, better beam transmission efficiency, better beam utilization efficiency of HIRFL-CSR accelerator complex and better operation efficiency of HIRFL can be obtained. In the first case, SSC can be used simultaneously in other purposes, either to accelerate medium energy heavy ions or to accelerate protons combined with another small cyclotron

  16. CSR Institutionalized Myths in Developing Countries

    DEFF Research Database (Denmark)

    Jamali, Dima; Lund-Thomsen, Peter; Khara, Navjote

    2015-01-01

    place, and how developing country firms can gain credit and traction by focusing on high visibility CSR issues, although the plight of workers remains fundamentally unchanged. The authors revisit these findings in the discussion and concluding sections, highlighting the main research and policy......This article examines joint action initiatives among small- and medium-sized enterprises (SMEs) in the manufacturing industries in developing countries in the context of the ascendancy of corporate social responsibility (CSR) and the proliferation of a variety of international accountability tools...... and standards. Through empirical fieldwork in the football manufacturing industry of Jalandhar in North India, the article documents how local cluster-based SMEs stay coupled with the global CSR agenda through joint CSR initiatives focusing on child labor. Probing further, however, also reveals patterns...

  17. The C.S.R. implementation

    Directory of Open Access Journals (Sweden)

    Mihaela Bucur

    2014-12-01

    Full Text Available The enterprises which started to integrate the principles of sustainable development in their activity, in their business processes and in their philosophy of business unfolding, require that Corporate Social Responsibility (CSR actions held by the companies involved a significant component of sustainable development. In practice, it would be beneficial if every direct action of the enterprise achieved long-lasting objectives and obtained sustainable results. The original contribution of this work is therefore essential for practitioners because it identifies a series of steps to be followed for the implementation and evaluation of a company's CSR activities. The present research addresses the need for implementing the concept of CSR in up companies. Our approach is drawn from several theoretical models, simplified for a beginner integrating CSR programs. Thus, in order to know what to start with, we have identified a number of simple steps and a methodology presented in this article.

  18. The Economic Virtues of SRI and CSR

    NARCIS (Netherlands)

    J. Derwall (Jeroen)

    2007-01-01

    textabstractFinancial markets and company managers are increasingly acknowledging the concepts of socially responsible investing (SRI) and corporate social responsibility (CSR), but not without reservations. These hesitations are largely attributable to ongoing debates about a potential conflict bet

  19. CSR REPORTING IN BANKS - THE ROMANIAN EVIDENCE

    Directory of Open Access Journals (Sweden)

    Georgiana-Loredana FRECEA

    2016-06-01

    Full Text Available The dynamics of the financial markets and the significant interrelationships with broader concepts as globalization or sustainable development, have led in recent years to the development of a multidimensional approach of CSR. The credibility of the financial system is based on the financial institutions image given by representative stakeholders. They filter in an objective way the ethical responsibilities of the banks and the legal ones and give them the legitimacy to operate on the market. In order to obtain a realistic framework of CSR in Romanian banks, the article will focus on the transparency of CSR information. The confidence crisis manifested in the banking institutions can best be overcome through an authentic reporting system, which is able to fulfill a set of requirements, from credibility to completeness. This paper highlights the main characteristics of the CSR reports provided by the Romanian banking institutions, based on the stakeholder theory and using international reporting frameworks as Global Reporting Initiative.

  20. Seal Structure of Vacuum System for CSR

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    To reach the design parameter of CSR, vacuum system (≤3.5x10~(-9) Pa), besides the high requirement for quality of the material and vacuum sanitation of the vacuum cells, the seal function is the most important. All cells of vacuum system for CSR are limited by the situations and rooms of gap of magnets, radio frequency system, diagnostic devices and others, and must meet the assemble and disassemble requirements of every devices.

  1. Establishing HIRFL-CSR Global Control Network

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    HIRFL-CSR global control network is used to define the correct location and orientation of accclcrator subsystems(i.e.CSRm,CSRe and Injection line)to each other.Each subsystem has its own control network,named the local control network.According to the local control network,thc components of each subsystem can be mounted to an ideal position.The original point of HIRFL-CSR global control network is on the mechanical

  2. Corporate Social Responsibility (CSR) - a Theoretical Approach

    OpenAIRE

    Bradu Cosmina Paula

    2011-01-01

    In the last years the expectations towards CSR are increasing and with this also the demand that businesses behave in a socially responsibly manner. But we should not forget that Corporate Social Responsibility (CSR) is a contested and also evolving concept, fact that is evidenced also by the different points of view concerning the definition and also by the lack of consensus about why it might be a worthy marketing objective. This article aims to ilustrate the main concepts and framworks reg...

  3. Credibility in CSR communication: concepts, methods, analyses

    OpenAIRE

    Lock, Irina; Seele, Peter

    2015-01-01

    In globalized markets, norms for legitimate behavior are scattered and businesses must satisfy often conflicting demands of various stakeholders simultaneously. This is why communicating their Corporate Social Responsibilities (CSR) in a legitimate way is challenging. The present is also a high time for a debate of CSR issues and an era of public scrutiny and mistrust, catalyzed by real-time communication technologies and a 24/7 news cycle. Instances of non-credible communication, the misus...

  4. SMEs and CSR in Developing Countries

    DEFF Research Database (Denmark)

    Jamali, Dima; Lund-Thomsen, Peter; Jeppesen, Søren

    2015-01-01

    This article is the guest editors’ introduction to the special issue in Business & Society on “SMEs and CSR in Developing Countries.” The special issue includes four original research articles by Hamann, Smith, Tashman, and Marshall; Allet; Egels-Zandén; and Puppim de Oliveira and Jabbour...... on various aspects of the relationship of small and medium enterprises (SMEs) to corporate social responsibility (CSR) in developing countries....

  5. The Quest for CSR in Closedowns

    OpenAIRE

    Rydell, Alexis; Wigblad, Rune

    2012-01-01

    This paper focuses on analysis of and suggestions for Corporate Social Responsibility (CSR) orienta- tion during the closedown process.The article addresses CSR considerations that adjust business strategies, which in turn change the Human Resource Management (HRM) focus. Our study fo- cuses on four best practice cases in Sweden, which are compared with three reported cases in the literature.All four best practice cases had a long notice period and socially responsible coordination of managem...

  6. CSR IN SMEs– SOME TERMINOLOGICAL DISTINCTIONS

    OpenAIRE

    Radu Florin OGARCA

    2013-01-01

    Corporate social responsibility (CSR) was traditionally considered a prerogative of large companies. In recent years, in practice and in the literature, specific activities of CSR have also been implemented in SMEs. Unfortunately (both in practical and theoretical dimensions), things are far from being clarified. More precisely, it seems that there is a gap between theory and practice, a transplantation of theory in practice not accurate enough. In the present paper, we intend to do some conc...

  7. Innovative fertility preservation strategies and programs for young adults with cancer

    OpenAIRE

    Johnson RH

    2016-01-01

    Rebecca H Johnson Division of Pediatric Hematology/Oncology, Department of Pediatrics, Mary Bridge Hospital, MultiCare Health System, Tacoma, WA, USA Abstract: Preservation of fertility is a key issue for young adults newly diagnosed with cancer. Up to 90% of cancer patients under the age of 45 are at risk for fertility impairment following cancer therapy. Cancer patients who are not offered fertility preservation (FP) and those who become infertile following therapy may experience long-term...

  8. Campaign awareness and oral cancer knowledge in UK resident adult Bangladeshi: a cross-sectional study

    OpenAIRE

    Croucher, R; Islam, S. S.; Nunn, H

    2011-01-01

    Background: This study reports awareness of the ‘Open up to Mouth Cancer' campaign materials and oral cancer knowledge among two UK adult Bangladeshi communities, both at high risk for oral cancer. Methods: Differences in the outcomes of campaign awareness and knowledge of oral cancer risk factors and early signs were compared between campaign and comparison areas. Home-based interviews were conducted with representative samples from both areas by bilingual interviewers. Data collected includ...

  9. csrR, a Paralog and Direct Target of CsrA, Promotes Legionella pneumophila Resilience in Water

    Science.gov (United States)

    Abbott, Zachary D.; Yakhnin, Helen; Babitzke, Paul

    2015-01-01

    ABSTRACT Critical to microbial versatility is the capacity to express the cohort of genes that increase fitness in different environments. Legionella pneumophila occupies extensive ecological space that includes diverse protists, pond water, engineered water systems, and mammalian lung macrophages. One mechanism that equips this opportunistic pathogen to adapt to fluctuating conditions is a switch between replicative and transmissive cell types that is controlled by the broadly conserved regulatory protein CsrA. A striking feature of the legionellae surveyed is that each of 14 strains encodes 4 to 7 csrA-like genes, candidate regulators of distinct fitness traits. Here we focus on the one csrA paralog (lpg1593) that, like the canonical csrA, is conserved in all 14 strains surveyed. Phenotypic analysis revealed that long-term survival in tap water is promoted by the lpg1593 locus, which we name csrR (for “CsrA-similar protein for resilience”). As predicted by its GGA motif, csrR mRNA was bound directly by the canonical CsrA protein, as judged by electromobility shift and RNA-footprinting assays. Furthermore, CsrA repressed translation of csrR mRNA in vivo, as determined by analysis of csrR-gfp reporters, csrR mRNA stability in the presence and absence of csrA expression, and mutation of the CsrA binding site identified on the csrR mRNA. Thus, CsrA not only governs the transition from replication to transmission but also represses translation of its paralog csrR when nutrients are available. We propose that, during prolonged starvation, relief of CsrA repression permits CsrR protein to coordinate L. pneumophila’s switch to a cell type that is resilient in water supplies. PMID:26060275

  10. CSR and aging workforces: An explorative study on CSR-implementation in SMEs

    NARCIS (Netherlands)

    Gellert , J. F.; De Graaf, J. F.

    2012-01-01

    Although critical differences exist between large companies and small- and medium-sized enterprises (SMEs), limited empirical research has been done on human resource (HR)-related corporate social responsibility (CSR). In this paper we study aging workforce management (AWM) as a component of CSR. Ou

  11. The Perspective of Social Business for CSR Strategy

    OpenAIRE

    Yokoyama, Keiko

    2009-01-01

    The growing practice of corporate social responsibility (CSR) has led to increasing research attention in the literature to the role of CSR strategy. CSR strategy is a concept for maximizing profits or benefits for both society and the company. Studies of CSR strategy during the 1990’s and the early 2000’s were mainly limited to examining the concept of CSR, and merely discussed the needs and importance of the strategic development of CSR. Recently, strategy researchers have proposed more spe...

  12. Internkommunikation av CSR : - En fallstudie av hur CSR internt förmedlas inom Clas Ohlson

    OpenAIRE

    Imeri, Dodona; Varatharajah, Kajany

    2012-01-01

    Den ökade transparensen i samhället har bidragit till att allt fler företag aktivt arbetar medCorporate Social Responsibility, CSR. Tyvärr är det många verksamheter idag som inte får tillräckligt mycket uppskattning för deras CSR-policy. Detta är för att den externa kommunikationen gentemot konsumenter inte är optimal. När konsumenter inte har kännedom om företagets CSR försvinner mycket av den konkurrenskraft som CSR bidrar med. Samtidigt kan en överdriven marknadsföring av företagets CSR-po...

  13. The cryogenic storage ring CSR

    Science.gov (United States)

    von Hahn, R.; Becker, A.; Berg, F.; Blaum, K.; Breitenfeldt, C.; Fadil, H.; Fellenberger, F.; Froese, M.; George, S.; Göck, J.; Grieser, M.; Grussie, F.; Guerin, E. A.; Heber, O.; Herwig, P.; Karthein, J.; Krantz, C.; Kreckel, H.; Lange, M.; Laux, F.; Lohmann, S.; Menk, S.; Meyer, C.; Mishra, P. M.; Novotný, O.; O'Connor, A. P.; Orlov, D. A.; Rappaport, M. L.; Repnow, R.; Saurabh, S.; Schippers, S.; Schröter, C. D.; Schwalm, D.; Schweikhard, L.; Sieber, T.; Shornikov, A.; Spruck, K.; Sunil Kumar, S.; Ullrich, J.; Urbain, X.; Vogel, S.; Wilhelm, P.; Wolf, A.; Zajfman, D.

    2016-06-01

    An electrostatic cryogenic storage ring, CSR, for beams of anions and cations with up to 300 keV kinetic energy per unit charge has been designed, constructed, and put into operation. With a circumference of 35 m, the ion-beam vacuum chambers and all beam optics are in a cryostat and cooled by a closed-cycle liquid helium system. At temperatures as low as (5.5 ± 1) K inside the ring, storage time constants of several minutes up to almost an hour were observed for atomic and molecular, anion and cation beams at an energy of 60 keV. The ion-beam intensity, energy-dependent closed-orbit shifts (dispersion), and the focusing properties of the machine were studied by a system of capacitive pickups. The Schottky-noise spectrum of the stored ions revealed a broadening of the momentum distribution on a time scale of 1000 s. Photodetachment of stored anions was used in the beam lifetime measurements. The detachment rate by anion collisions with residual-gas molecules was found to be extremely low. A residual-gas density below 140 cm-3 is derived, equivalent to a room-temperature pressure below 10-14 mbar. Fast atomic, molecular, and cluster ion beams stored for long periods of time in a cryogenic environment will allow experiments on collision- and radiation-induced fragmentation processes of ions in known internal quantum states with merged and crossed photon and particle beams.

  14. The Cryogenic Storage Ring CSR

    CERN Document Server

    von Hahn, Robert; Berg, Felix; Blaum, Klaus; Breitenfeldt, Christian; Fadil, Hisham; Fellenberger, Florian; Froese, Michael; George, Sebastian; Göck, Jürgen; Grieser, Manfred; Grussie, Florian; Guerin, Elisabeth A; Heber, Oded; Herwig, Philipp; Karthein, Jonas; Krantz, Claude; Kreckel, Holger; Lange, Michael; Laux, Felix; Lohmann, Svenja; Menk, Sebastian; Meyer, Christian; Mishra, Preeti M; Novotný, Oldřich; Connor, Aodh P O; Orlov, Dmitry A; Rappaport, Michael L; Repnow, Roland; Saurabh, Sunny; Schippers, Stefan; Schröter, Claus Dieter; Schwalm, Dirk; Schweikhard, Lutz; Sieber, Thomas; Shornikov, Andrey; Spruck, Kaija; Kumar, Sudhakaran Sunil; Ullrich, Joachim; Urbain, Xavier; Vogel, Stephen; Wilhelm, Patrick; Wolf, Andreas; Zajfman, Daniel

    2016-01-01

    An electrostatic cryogenic storage ring, CSR, for beams of anions and cations with up to 300 keV kinetic energy per unit charge has been designed, constructed and put into operation. With a circumference of 35 m, the ion-beam vacuum chambers and all beam optics are in a cryostat and cooled by a closed-cycle liquid helium system. At temperatures as low as (5.5 $\\pm$ 1) K inside the ring, storage time constants of several minutes up to almost an hour were observed for atomic and molecular, anion and cation beams at an energy of 60 keV. The ion-beam intensity, energy-dependent closed-orbit shifts (dispersion) and the focusing properties of the machine were studied by a system of capacitive pickups. The Schottky-noise spectrum of the stored ions revealed a broadening of the momentum distribution on a time scale of 1000 s. Photodetachment of stored anions was used in the beam lifetime measurements. The detachment rate by anion collisions with residual-gas molecules was found to be extremely low. A residual-gas den...

  15. The cryogenic storage ring CSR.

    Science.gov (United States)

    von Hahn, R; Becker, A; Berg, F; Blaum, K; Breitenfeldt, C; Fadil, H; Fellenberger, F; Froese, M; George, S; Göck, J; Grieser, M; Grussie, F; Guerin, E A; Heber, O; Herwig, P; Karthein, J; Krantz, C; Kreckel, H; Lange, M; Laux, F; Lohmann, S; Menk, S; Meyer, C; Mishra, P M; Novotný, O; O'Connor, A P; Orlov, D A; Rappaport, M L; Repnow, R; Saurabh, S; Schippers, S; Schröter, C D; Schwalm, D; Schweikhard, L; Sieber, T; Shornikov, A; Spruck, K; Sunil Kumar, S; Ullrich, J; Urbain, X; Vogel, S; Wilhelm, P; Wolf, A; Zajfman, D

    2016-06-01

    An electrostatic cryogenic storage ring, CSR, for beams of anions and cations with up to 300 keV kinetic energy per unit charge has been designed, constructed, and put into operation. With a circumference of 35 m, the ion-beam vacuum chambers and all beam optics are in a cryostat and cooled by a closed-cycle liquid helium system. At temperatures as low as (5.5 ± 1) K inside the ring, storage time constants of several minutes up to almost an hour were observed for atomic and molecular, anion and cation beams at an energy of 60 keV. The ion-beam intensity, energy-dependent closed-orbit shifts (dispersion), and the focusing properties of the machine were studied by a system of capacitive pickups. The Schottky-noise spectrum of the stored ions revealed a broadening of the momentum distribution on a time scale of 1000 s. Photodetachment of stored anions was used in the beam lifetime measurements. The detachment rate by anion collisions with residual-gas molecules was found to be extremely low. A residual-gas density below 140 cm(-3) is derived, equivalent to a room-temperature pressure below 10(-14) mbar. Fast atomic, molecular, and cluster ion beams stored for long periods of time in a cryogenic environment will allow experiments on collision- and radiation-induced fragmentation processes of ions in known internal quantum states with merged and crossed photon and particle beams. PMID:27370434

  16. Pediatric Cancers and Brain Tumors in Adolescents and Young Adults.

    Science.gov (United States)

    McCabe, Martin G; Valteau-Couanet, Dominique

    2016-01-01

    Embryonal tumors classically occur in young children, some principally within the first year of life. Prospective national and international clinical trials during recent decades have brought about progressive improvements in survival, and associated biological studies have advanced our understanding of tumor biology, in some cases allowing biological tumor characteristics to be harnessed for therapeutic benefit. Embryonal tumors continue to occur, albeit less commonly, during childhood, adolescence and throughout adulthood. These tumors are less well understood, usually not managed according to standardized protocols and rarely included in clinical trials. Survival outcomes are generally poorer than their childhood equivalents. We present here a summary of the published literature on embryonal tumors that present ectopically during adolescence and adulthood. We show that for some tumors protocol-driven treatment, supported by accurate and complete diagnostics and staging, can result in equivalent outcomes to those seen during childhood. We make the case that clinical trial eligibility criteria should be disease-based rather than age-based, and support improvements in dialogue between children's and adults' cancer clinicians to improve outcomes for these rare tumors. PMID:27595358

  17. Internet-Based Physical Activity Intervention Targeting Young Adult Cancer Survivors

    OpenAIRE

    Rabin, Carolyn; Dunsiger, Shira; Ness, Kirsten K.; Marcus, Bess H

    2011-01-01

    Purpose: Young adults who have been treated for cancer face several health and psychosocial risks. To minimize these risks, is it imperative that they address any modifiable risk factors, such as sedentary lifestyle. Unfortunately, more than half of young adult cancer survivors remain sedentary. To facilitate the adoption of physical activity (PA) in this population—potentially reducing health and psychosocial risks—we developed and pilot tested an internet-based PA intervention for young sur...

  18. Detangling Value: A study into the benefits of using in-house CSR expertise compared with the benefits of using CSR consultancy expertise

    OpenAIRE

    MacCarthy, Jennifer

    2007-01-01

    Abstract The topic of Corporate Social Responsibility (CSR) is an area with an increasing breadth of literature. However, literature regarding how CSR expertise is sourced for developing CSR projects and programmes within companies is distinctly weak. This study takes, arguably, the two most predominant forms of CSR expertise, in-house CSR expertise and CSR consultancies, and investigates what value these different types of expertise offer in sourcing for CSR activities. Bey...

  19. The CsrR/CsrS two-component system of group A Streptococcus responds to environmental Mg2+

    OpenAIRE

    Gryllos, Ioannis; Levin, James C.; Wessels, Michael R.

    2003-01-01

    Group A streptococci control expression of key virulence determinants via the two-component sensor/regulator system CsrR/CsrS. The membrane-bound sensor CsrS is thought to respond to previously unknown environmental signal(s) by controlling phosphorylation of its cognate regulator component CsrR. Phosphorylation of CsrR increases its affinity for binding to the promoter regions of Csr-regulated genes to repress transcription. Here we show that environmental Mg2+ concentration is a potent and ...

  20. Cancer incidence among adolescents and young adults in urban Shanghai, 1973-2005.

    Directory of Open Access Journals (Sweden)

    Qi-Jun Wu

    Full Text Available BACKGROUND: Lack of cancer incidence information for adolescents and young adults led us to describe incidence trends within the young population of 15 to 49 year-olds in urban Shanghai between 1973 and 2005. METHODS: During 1973 to 2005, data on 43,009 (45.8% male and 50,828 (54.2% female cancer cases aged 15-49 years from the Shanghai Cancer Registry were analyzed. Five-year age-specific rates, world age-standardized rates, percent change (PC, and annual percent change (APC were calculated using annual data on population size and its estimated age structure. RESULTS: During the 33-year study period, overall cancer incidence of adolescents and young adults among males marginally decreased by 0.5% per year (P<0.05. However, overall cancer incidence for females slightly increased by 0.8% per year (P<0.05. The leading cancer for males in rank were liver, stomach, lung, colorectal, and nasopharyngeal cancers and for females were breast, stomach, colorectal, thyroid, and ovarian cancers. Among specific sites, incidence rates significantly decreased for cancers of the esophagus, stomach, and liver in both sexes. In contrast, incidence rates significantly increased for kidney cancers, non-Hodgkin lymphoma, and brain and nervous system tumors in both sexes and increased for breast and ovarian cancers among females. CONCLUSIONS: Overall cancer incidence rates of adolescents and young adults decreased in males whereas they increased in females. Our findings suggest the importance of further epidemiology and etiologic studies to further elucidate factors contributing to the cancer incidence trends of adolescents and young adults in China.

  1. Study of CSR longitudinal bunch compression cavity

    International Nuclear Information System (INIS)

    The scheme of longitudinal bunch compression cavity for the Cooling Storage Ring (CSR)is an important issue. Plasma physics experiments require high density heavy ion beam and short pulsed bunch,which can be produced by non-adiabatic compression of bunch implemented by a fast compression with 90 degree rotation in the longitudinal phase space. The phase space rotation in fast compression is initiated by a fast jump of the RF-voltage amplitude. For this purpose, the CSR longitudinal bunch compression cavity, loaded with FINEMET-FT-1M is studied and simulated with MAFIA code. In this paper, the CSR longitudinal bunch compression cavity is simulated and the initial bunch length of 238U72+ with 250 MeV/u will be compressed from 200 ns to 50 ns.The construction and RF properties of the CSR longitudinal bunch compression cavity are simulated and calculated also with MAFIA code. The operation frequency of the cavity is 1.15 MHz with peak voltage of 80 kV, and the cavity can be used to compress heavy ions in the CSR. (authors)

  2. IMPLICATIONS OF CSR ON CORPORATE STAKEHOLDERS

    Directory of Open Access Journals (Sweden)

    Crisan Catalina

    2015-07-01

    Full Text Available Companies’ strategies and values must be in accordance to stakeholders’ expectations and needs because their role and influences on companies’ activity are decisive for companies future development. Corporate Social Responsibility is a meaningful way through which companies can pursue sustainable development by having a coherent economical, social and environmental perspective on how the business should be managed. CSR must become an integral part of corporate management system, because it has a major role in distressing the relation between company and major stakeholders, both internally and externally. CSR is a global phenomenon, which draws the attention of a growing number of partisans, from public private and social sector. To demonstrate the applicability of the theoretical approaches deduced from the existing literature, the authors recourse to an empirical qualitative research, conducted through a questionnaire implemented to top managers, HR managers and heads of CSR departments within large companies that operate in Romania. The research is based on the analysis of a number of 87 questionnaires and aims to highlight major stakeholders and finding how companies’ responsible activities can influence stakeholders. This study is designed to highlight how prioritization of stakeholders influences CSR initiatives within large companies that operate in Romania, and to present a perspective of company’s approach towards shared value influence major stakeholders. The conclusions drawn have a greater relevance both theoretically and especially practically because provides insights on how large companies perceive CSR and how stakeholders influence responsible initiatives in emergent country like Romania where stereotypes are difficult to manage.

  3. Comprehension of a Colon Cancer Pamphlet among American Adults at Least 50 Years of Age

    Science.gov (United States)

    Liu, Chiung-ju

    2010-01-01

    Objective: The purpose of this study was to identify determinants of comprehension of an educational pamphlet on colon cancer, by adults at least 50 years of age living in the United States. Design: Data were analysed from the "2003 National Assessment of Adult Literacy" survey. The survey was designed to assess functional English literacy, which…

  4. Reviewing CSR management and marketing communication research: A discourse approach

    DEFF Research Database (Denmark)

    Nielsen, Anne Ellerup; Thomsen, Christa

    , corporate reputation and value creation (e.g. Porter & Kramer 2006; Du et al. 2010). By looking at the rapidly growing body of research in the field of CSR management and marketing communication, the paper focuses on the positions, arguments, conflicts and actors of CSR communication across specific CSR...... includes stakeholders in or around business units established in developing countries and emerging markets (e.g. Jamali 2010; Reimann 2012). Along with the growing pressure on corporations to engage in CSR a seemingly growing number of these are concerned with disclosure, reporting, reputation, etc. issues...... extent CSR communication may contribute to influence stakeholders’ perception of corporations’ CSR performance. At best, some studies hold that there is a general recognition of CSR communication as a potential reputation enhancer, but also that if addressed inappropriately, CSR communication cause more...

  5. Body mass index in childhood and adult risk of primary liver cancer

    DEFF Research Database (Denmark)

    Berentzen, Tina Landsvig; Gamborg, Michael; Holst, Claus;

    2014-01-01

    BACKGROUND & AIMS: Childhood overweight increases the risk of early development of non-alcoholic fatty liver disease, which may predispose to carcinogenesis. We investigated if childhood body size during school ages was associated with the risk of primary liver cancer in adults. METHODS: A cohort......-specific reference. Information on liver cancer was obtained from the National Cancer Registry. Hazard ratios and 95% confidence intervals (95% CI) of liver cancer were estimated by Cox regression. RESULTS: During 6,963,105 person-years of follow-up, 438 cases of primary liver cancer were recorded. The hazard ratio...... (95% CI) of adult liver cancer was 1.20 (1.07-1.33) and 1.30 (1.16-1.46) per 1-unit BMI z-score at 7 years and 13 years of age, respectively. Similar associations were found in boys and girls, for hepatocellular carcinoma only, across years of birth, and after accounting for diagnoses of viral...

  6. Consumer perceptions of CSR: (how) is China different?

    OpenAIRE

    Kolk, A.; Dolen, van, W.; Ma, L

    2015-01-01

    Purpose Most studies on consumers and corporate social responsibility (CSR) have focused on Western contexts. Consequently, good insight is lacking into non-Western markets where consumers may respond differently. China is a case in point, despite the popularity of the CSR concept and high societal expectations of firms. The purpose of this paper is to examine how Chinese consumers perceive the underlying components of CSR found in Western countries; whether their CSR expectations differ for ...

  7. Importance of outcomes Measurement of CSR programmes - Case Nokia

    OpenAIRE

    Talvitie-Sirén, Reeta

    2009-01-01

    Abstract: Objectives of the Thesis The objective of the thesis was to find out how companies measure the societal and business outcomes of their CSR activities as well as to find out the reasons why outcomes measurement is considered important. The focus was on the societal aspect of CSR, and all programmes studied were community related CSR programmes. The programmes studied were categorised according to a framework of CSR action types modified from Halme and Laurila (2009). A fourth cate...

  8. Measurement of intensity distribution of CSR in LEBRA PXR beamline

    International Nuclear Information System (INIS)

    Last year, the intensity of Coherent Synchrotron Radiation (CSR) in LEBRA PXR beamline was measured. As a result, it turned out that the intensity of CSR was stronger than anticipation. It is suggested that Coherent Edge Radiation (CER) is mixed with CSR. Then, in order to confirm whether CER is contained, the intensity distribution of CSR was measured. The result of the experiment is reported in this paper. (author)

  9. Empirical Analysis on CSR Communication in Romania: Transparency and Participation

    OpenAIRE

    Irina-Eugenia Iamandi

    2012-01-01

    In the specific field of corporate social responsibility (CSR), the participation of companies in supporting social and environmental issues is mainly analysed and/or measured based on their CSR communication policy; in this way, the transparency of the CSR reporting procedures is one of the most precise challenges for researchers and practitioners in the field. The main research objective of the present paper is to distinguish between different types of CSR participation by identifying the r...

  10. How do Domestic Institutions Influence Corporate Social Responsibility (CSR)?

    OpenAIRE

    Brown, Dana; Steen Kundsen, Jette

    2012-01-01

    The literature explains the link between CSR and domestic institutions in terms of the presence of national institutional complementarities as a key determinant of a company’s CSR initiatives. One set of explanations sees CSR as fitting in with domestic institutional structures as either `substituting’ or ‘mirroring’ government policies. A second set of explanations views CSR as driven by variations in competitive needs across countries, reflecting in particular the degree of international ma...

  11. CEO letters in CSR reports: oil companies in focus

    OpenAIRE

    von Berg, Marhaba

    2013-01-01

    Objectives of the study: A main challenge in planning CSR communication strategy is how to communicate positive motives of a corporation in its CSR activities and how to decrease stakeholder uncertainty. This study provides an analysis of the CEO letters issued by eight oil companies in their CSR reports. The thesis is an investigation of target stakeholder group and move-structure carried out to determine the communicative purpose of CEO letters in CSR reports of eight oil companies. The...

  12. CSR: Transparency and the role of intermediate organisations

    OpenAIRE

    Dubbink, G.W.; Graafland, J.J.; Liederkerke, L.

    2008-01-01

    Transparency is a crucial condition to implement a CSR policy based on the reputation mechanism. The central question of this contribution is how a transparency policy ought to be organised in order to enhance the CSR behaviour of companies. Governments endorsing CSR as a new means of governance have different strategies to foster CSR transparency. In this paper we discuss the advantages and disadvantages of two conventional policy strategies: the facilitation policy and the command and contr...

  13. Consumers’ responses to CSR in a cross-cultural setting

    OpenAIRE

    Hakan Karaosman; Gustavo Morales-Alonso; Mercedes Grijalvo

    2015-01-01

    The paper aims to clarify the relationship between corporate social responsibility (CSR) and consumer behaviour in an international setting. Consumers’ responses to CSR activities and the impact on the purchase decision are limited discourses. CSR-based studies in the fashion and apparel industry are also scarce. Therefore, this study attempts to enlighten the subject of how consumers from different countries respond to CSR adopted in the fashion and apparel industry. This study is based on a...

  14. The radiation protection design of CSR

    International Nuclear Information System (INIS)

    The construction of CSR (Cooling Storage Ring) which include a main ring (CSRm) and an experimental ring (CSRe) will be started in this year. Heavy ions of carbon to uranium will be accelerated up to 900MeV/u and 400MeV/u at intensity of 108 pps. For the shielding design of CSR, the secondary neutron yields due to ion beam loss and their spectra, angular distributions were estimated based on the experimental results for 400 MeV/u 12C+Cu reaction by K. Nakamura et.al.. The equivalent dose at the shield surface and in the surrounding environment, skyshine neutron dose equivalent and air-induced radioactivity were also estimated in this study. It is found that the most important environmental radiation impact component of CSR is the skyshine neutrons, and the environmental impact due to air and cooling water induced radioactivity were lesser. (author)

  15. Liberal CSR and New Marxist Criticism

    DEFF Research Database (Denmark)

    Toft, Kristian Høyer

    2014-01-01

    The term ‘corporate social responsibility’ (CSR) is considered by the new Marxist left to be a self-defeating oxymoron. In this chapter, the new Marxist challenge to CSR as a meaningful, coherent concept and practice is discussed. In the wake of the financial crisis the critique from the Marxist......-inspired left tends to replace the scepticism of the libertarian right (Friedman 1970). The legitimacy of business in society is at stake, and the critical left is well placed to debunk the integrity of business’s claim to social responsibility. To provide an overview of current Marxist inspired CSR thinking......, this chapter introduces the Hegelian inspired critique of a New Spirit of Capitalism (Chiapello 2013) as well as the critique of ideology targeted at the neo-liberal project of corporate responsibility (Žižek 2008; Fleming and Jones 2013). Subsequently, two possible liberal ‘revisions’ to the Marxist inspired...

  16. Association Between Diagnosed Diabetes and Self-Reported Cancer Among U.S. Adults

    OpenAIRE

    Li, Chaoyang; Balluz, Lina S; Ford, Earl S.; Okoro, Catherine A; Tsai, James; Zhao, Guixiang

    2011-01-01

    OBJECTIVE To assess the association between diagnosed diabetes and self-reported cancer among U.S. adults. RESEARCH DESIGN AND METHODS We analyzed data for 397,783 adults who participated in the 2009 Behavioral Risk Factor Surveillance System and had valid data on diabetes and cancer. RESULTS After adjustment for potential confounders, diabetic men had higher adjusted prevalence ratios for cancers of the prostate (1.1 [95% CI 1.0–1.3]), colon (1.3 [1.0–1.7]), pancreas (4.6 [1.8–11.7]), rectum...

  17. CSR och politisk konsumtion : - en studie av Nikes och Pumas CSR- rapporter

    OpenAIRE

    Björling, Ameli

    2010-01-01

    CSR and political consumption – a study of Nike’s and Puma’s CSR-reports” The purpose of this dissertation is to examine if political consumption has influenced multinational corporations to improve their Corporate Social Responsibility reports and policies more, than a company who has not been a target for political consumption. This dissertation is a content analysis of Nike’s and Puma’s first (Nike 2001, Puma 2001) and latest (Nike 2007/09, Puma 2007/08) CSR- reports. Archie Carroll’s mod...

  18. Nanshan Aluminum Reached Strategic Cooperation with CSR Corporation Limited

    Institute of Scientific and Technical Information of China (English)

    2015-01-01

    As a key supplier of aluminum profiles and aluminum plate,sheet and trip products for CSR Corporation Limited,Nanshan Aluminum will join hands with CSR Corporation Limited to reach strategic cooperation.On January 5,Nanshan Aluminum signed strategic cooperation agreement with CSR Sifang Locomotive&Rolling; Stock Co.,Ltd,both

  19. CSR of Lanzhou and nuclear physics at high densities

    International Nuclear Information System (INIS)

    The possibility to produce highly dense nuclear matter at CSR of Lanzhou and the corresponding signals at final state are discussed. Especially, the maximum baryon density reached at CSR is estimated, and the subthreshold production and hadronic flow risen from the partial restoration of chiral symmetry at CSR energies are analyzed

  20. Implementation: Measuring and Explaining the Fidelity of CSR Implementation

    Science.gov (United States)

    Kurki, Anja; Boyle, Andrea; Aladjem, Daniel K.

    2006-01-01

    Comprehensive school reform (CSR) is only as effective as its implementation. By using data collected for the National Longitudinal Evaluation of Comprehensive School Reform (NLECSR), this article explores the factors that predict CSR model implementation and the ways that CSR model implementation varies. We found little difference in the fidelity…

  1. Security of Operation on CSR Control System

    Institute of Scientific and Technical Information of China (English)

    GouShizhe; QiaoWeimin; JingLan

    2003-01-01

    It is important to the security of operation on the CSR control system. In order to keep the CSR control system in security environment, the following work has been done. Firstly, it can be set up a domain service, and every important services can join in it, such as databasese rvices, front web services and every interactive operating browsers, and limited the browsers right by using policy of the domain. After this, the browsers can't modify the setting of the browser, and it can keep every computers and browsers in security by preventing some virus into each computer. The domain services of control system is shown in Fig.1.

  2. The effect of adaptive servo ventilation (ASV) on objective and subjective outcomes in Cheyne-Stokes respiration (CSR) with central sleep apnea (CSA) in heart failure (HF): A systematic review.

    Science.gov (United States)

    Yang, Hyunju; Sawyer, Amy M

    2016-01-01

    To summarize the current evidence for adaptive servo ventilation (ASV) in Cheyne-Stokes respiration (CSR) with central sleep apnea (CSA) in heart failure (HF) and advance a research agenda and clinical considerations for ASV-treated CSR-CSA in HF. CSR-CSA in HF is associated with higher overall mortality, worse outcomes and lower quality of life (QOL) than HF without CSR-CSA. Five databases were searched using key words (n = 234). Randomized controlled trials assessed objective sleep quality, cardiac, and self-reported outcomes in adults (≥18 years) with HF (n = 10). ASV has a beneficial effect on the reduction of central sleep apnea in adult patients with CSR-CSA in HF, but it is not be superior to CPAP, bilevel PPV, or supplemental oxygen in terms of sleep quality defined by polysomnography, cardiovascular outcomes, subjective daytime sleepiness, and quality of life. ASV is not recommended for CSR-CSA in HF. It is important to continue to refer HF patients for sleep evaluation to clearly discern OSA from CSR-CSA. Symptom management research, inclusive of objective and subjective outcomes, in CSR-CSA in HF adults is needed.

  3. The effect of adaptive servo ventilation (ASV) on objective and subjective outcomes in Cheyne-Stokes respiration (CSR) with central sleep apnea (CSA) in heart failure (HF): A systematic review.

    Science.gov (United States)

    Yang, Hyunju; Sawyer, Amy M

    2016-01-01

    To summarize the current evidence for adaptive servo ventilation (ASV) in Cheyne-Stokes respiration (CSR) with central sleep apnea (CSA) in heart failure (HF) and advance a research agenda and clinical considerations for ASV-treated CSR-CSA in HF. CSR-CSA in HF is associated with higher overall mortality, worse outcomes and lower quality of life (QOL) than HF without CSR-CSA. Five databases were searched using key words (n = 234). Randomized controlled trials assessed objective sleep quality, cardiac, and self-reported outcomes in adults (≥18 years) with HF (n = 10). ASV has a beneficial effect on the reduction of central sleep apnea in adult patients with CSR-CSA in HF, but it is not be superior to CPAP, bilevel PPV, or supplemental oxygen in terms of sleep quality defined by polysomnography, cardiovascular outcomes, subjective daytime sleepiness, and quality of life. ASV is not recommended for CSR-CSA in HF. It is important to continue to refer HF patients for sleep evaluation to clearly discern OSA from CSR-CSA. Symptom management research, inclusive of objective and subjective outcomes, in CSR-CSA in HF adults is needed. PMID:26995256

  4. How Personal Values Influence Romanian CSR Managers` Involvment in CSR Campaigns

    Directory of Open Access Journals (Sweden)

    Anca Diana ȘERBAN

    2015-12-01

    Full Text Available This study focuses on identifying the ratio between the individual and organization authority of CSR managers concerning decision making within the campaigns they coordinate. The sample includes the top 100 Romanian companies selected by turnover. The way in which the managers’ values interact with the organization authority is a subject treated poorly in both international and Romanian literature. This study, which has an exploratory character, investigates how personal values lead Romanian CSR managers to develop and coordonate CSR campaigns and to what extent these values are part of the campaign messages compared to the values of the company for which they are made. The main results of this scientific paper refers to the correlation between the CSR managers’ values and the campaigns that they coordinate.

  5. Environmental policy and CSR: How climate change is interpreted in CSR reports of Greek companies

    OpenAIRE

    Metaxas, Theodore; Tsavdaridou, Maria

    2014-01-01

    The environmental policy and Corporate Social Responsibility are two notions of high importance for enterprises and nations. Numerous pages have been written about the environmental policy of companies in their CSR reports. Whether it concerns to raise environmental awareness among their employees or local communities or to give in detail their environmental footprint at the end of the story it is about giving proofs of their environmental policy. Climate change is among the topics of CSR rep...

  6. Corporate Social Responsibility (CSR) : a participatory approach to implementing CSR in a cluster

    OpenAIRE

    Høivik, Heidi von Weltzien; Shankar, Deepthi

    2010-01-01

    This report is focused on why and how a participatory approach to implement Corporate Social Responsibility (CSR) in a cluster would be beneficial for Small and Medium-sized Enterprises (SMEs) in the Norwegian Center of Expertise (NCE) Subsea cluster in Bergen, Norway. The political and strategic reasons, as well as internal motivation, for SMEs to incorporate CSR into their business strategies are discussed with support from relevant literature. Furthermore, the report reviews differ...

  7. CSR: Fordrende? Forhindrende? Forandrende? - Et speciale om CSR i små og mellemstore virksomheder

    OpenAIRE

    Gertov, Alexandra Rahbek; Thorarinsson, Lina Kamilla; Villumsen, Anne Katrine Holst Høiberg

    2016-01-01

    This thesis examines the barriers SME’s experience when they try including CSR-initiatives in their business practices. We conduct a qualitative case study of six companies whose narratives we have interpreted through Paul Ricoeur's methods and Karl. E. Weick's sensemaking concepts. Through a phenomenological-hermeneutic method of interpretation, we derived 10 barriers that obstruct the case companies in recognizing opportunities within a CSR-sphere. We conclude that barriers as a concept can...

  8. CSR-communication in the Business Press

    DEFF Research Database (Denmark)

    Morsing, Mette; Langer, Roy

    In this paper we analyze the construction of corporate social responsibility in the business press as an act of strategic ambiguity. While corporate social responsibility (CSR) generally evokes positive associations in public opinion, this paper demonstrates that these associations are based...

  9. CSR Position in the Top Management Team

    DEFF Research Database (Denmark)

    Strand, Robert

    Recently, a number of positions with corporate social responsibility (CSR) in the position title have been introduced to the top management teams (TMTs) of some of the world’s largest corporations. I explore this phenomenon. I revisit 10 such positions identified in a previous study to add a...

  10. CSR observations at the ANKA storage ring

    Energy Technology Data Exchange (ETDEWEB)

    Judin, Vitali; Hiller, Nicole; Hofmann, Andre; Huttel, Erhard; Kehrer, Benjamin; Klein, Marit; Marsching, Sebastian; Meuter, Christina; Mueller, Anke-Susanne; Nasse, Michael Johannes; Schuh, Marcel; Smale, Nigel John; Streichert, Max Igor [Karlsruher Institut fuer Technologie, Karlsruhe (Germany)

    2012-07-01

    ANKA is a synchrotron light source situated at the Karlsruhe Institute of Technology. Using dedicated low-{alpha}-optics at ANKA we can reduce the bunch length and generate Coherent Synchrotron Radiation (CSR). Studies of the coherent emission in the time domain and spectral measurements in the THz range allow us to gain insight into the longitudinal bunch dynamics.

  11. HIRFL–CSR internal cluster target

    International Nuclear Information System (INIS)

    Highlights: • An internal cluster target was built and installed at HIRFL–CSR. • The target thickness for H2 amounts up to 6.6 × 1012 atoms/cm2. • The feasibility and stability of the internal cluster target were verified by on-line experiments. -- Abstract: Since HIRFL–CSR internal cluster target was built, it has played a key role in in-ring experiments at HIRFL–CSR. So far it have been operated with five gas species as targets for scattering experiments, i.e. hydrogen, nitrogen, argon, neon, and krypton. The obtained highest thickness for hydrogen target amounts up to 1012 atoms/cm2, and those of other targets are larger than 1013 atoms/cm2 with the background pressure of 10−11 mbar in CSR. The target thickness can be varied by regulating the nozzle temperature and pressure of the inlet gas. The first online internal target experiment dedicated to investigate radioactive electron capture (REC) process with Xe54+ ions colliding with the nitrogen target demonstrated the stability and reliability of the internal target system. In addition, hydrogen and krypton were also tested online in recent experiments, which indicate the target system can meet experimental requirements for the thickness of target, pressure in scattering chamber, and long-term stability

  12. A Public Governance Look at CSR

    DEFF Research Database (Denmark)

    Buhmann, Karin

    2014-01-01

    parameters combine with normative guidance based on CSR norms (e.g. the UN Global Compact, OECD’s Guidelines for Multinational Enterprises, the UN Guidelines on Business and Human Rights). Focusing on debates concerning resource extraction operations in Greenland and the pertinent policy framework...

  13. Governmentality and the Politics of CSR

    DEFF Research Database (Denmark)

    Vallentin, Steen; Murillo, David

    2012-01-01

    ) promotes a strategic understanding of CSR as a lever for economic competitiveness and growth and b) disregards regulatory measures in favour of liberal and indirect means of steering. We argue that the analytical vocabulary of governmentality makes it possible to address and problematize the indirect modes...

  14. Case Study of the Development of CSR in Danfoss

    DEFF Research Database (Denmark)

    Ma, Rufei; Toh, ImnLin; Christensen, Per;

    ”, “Volunteering” as CSR Modes. Its positive learning capacity is a contributing factor to its conducive environment for CSR to flourish. The development of CSR in Danfoss was a gradual progression influenced by its concern for its employees, environmental and labour market issues, and its commitment to the UN......This work‐in‐progress focuses on the CSR practice within the Danfoss Group, a leading global manufacturing company based in Denmark. Its mechanism in CSR policy making and its learning capacity in reaction to changes that may be caused by major events (climate change and the current financial...... questionnaire surveys with those at management level and also to the general employees. The outcome of the research shows that Danfoss is at an advanced stage of CSR development. It is engaging more in the second and third CSR waves (Products & Processes and Employee Relations), using “Foundation...

  15. The Current State of CSR Consultancy Development in Russia and the United Kingdom

    OpenAIRE

    Armley, Natasha

    2005-01-01

    The research examines the phenomenon of corporate social responsibility (CSR) consultancy in Russia, as a new growing market, in comparison with well defined CSR consultancy in the UK, more advanced in CSR traditions and practices. The introduction to CSR consultancy has been made through a prism of CSR definitions: how it is interpreted in the West and Russia. Significant attention has been paid to analysing the UK and Russia national CSR systems combining the major drivers of CSR develo...

  16. Comparison analysis between CSR-OT and CSR-H for corrugated bulkhead of large product tankers

    Institute of Scientific and Technical Information of China (English)

    蔡诗剑; 邱伟强; 刘奕谦

    2014-01-01

    Large Aframax product tanker (more than 100k DWT), with centerline longitudinal corrugated bulkheads and transverse corrugated bulkheads in cargo area, is the largest type of product tanker at present. The external draft of Harmonized Common Structural Rules (CSR-H) for Bulk Carriers and Oil Tankers is released for external review. More attentions are paid to the impact of CSR-H on the structural design of the corrugated bulkhead of large Aframax product tankers. Based on CSR-OT and CSR-H, it discusses the impact of CSR-H on the corrugated bulkhead by strength assessment of a 115k DWT product tanker.

  17. Innovative fertility preservation strategies and programs for young adults with cancer

    Directory of Open Access Journals (Sweden)

    Johnson RH

    2016-01-01

    Full Text Available Rebecca H Johnson Division of Pediatric Hematology/Oncology, Department of Pediatrics, Mary Bridge Hospital, MultiCare Health System, Tacoma, WA, USA Abstract: Preservation of fertility is a key issue for young adults newly diagnosed with cancer. Up to 90% of cancer patients under the age of 45 are at risk for fertility impairment following cancer therapy. Cancer patients who are not offered fertility preservation (FP and those who become infertile following therapy may experience long-term psychosocial distress. This review summarizes the numerous effective strategies for preserving fertility, including sperm banking, electroejaculation, and testicular sperm extraction in males and cryopreservation of embryos or oocytes in females. This paper also highlights novel methods currently in development, such as gonadal tissue cryopreservation and in vitro maturation of gametes. In women, anti-Mullerian hormone is emerging as an accurate marker of ovarian reserve, and the use of gonadotropin releasing hormone analogs to protect fertility is increasingly well validated. Although national guidelines mandate FP counseling and referral prior to the start of cancer therapy for patients with reproductive potential, only a minority of young cancer patients in the USA currently take steps to preserve fertility prior to the start of therapy. Some cancer centers across the USA are developing institutional strategies to support FP, resulting in increased utilization of fertility services by newly diagnosed cancer patients. Keywords: young adult, cancer, fertility preservation, program, oocyte, sperm

  18. Bladder cancer in HIV-infected adults: an emerging concern?

    Directory of Open Access Journals (Sweden)

    Sylvain Chawki

    2014-11-01

    Full Text Available Introduction: As HIV-infected patients get older more non-AIDS-related malignancies are to be seen. Cancer now represents almost one third of all causes of deaths among HIV-infected patients (1. Albeit bladder cancer is one of the most common malignancy worldwide (2, only 13 cases of bladder cancer in HIV-infected patients have been reported in the literature so far (3. Materials and Methods: We conducted a monocentric study in our hospital. We selected all patients who were previously admitted (from 1998 to 2013 in our hospital with diagnoses of HIV and bladder cancer. The objective was to assess the prevalence and characteristics of bladder cancers in HIV-infected patients in our hospital. Results: Based on our administrative HIV database (6353 patients, we found 15 patients (0.2% with a bladder cancer. Patients’ characteristics are presented in Table 1. Patients were mostly men and heavy smokers. Their median nadir CD4 cell count was below 200 and most had a diagnosis of AIDS. A median time of 14 years was observed in those patients, between the diagnosis of HIV-infection and the occurrence of bladder cancer, although in patients much younger (median age 56 than those developing bladder cancer without HIV infection (71.1 years (4. Haematuria was the most frequent diagnosis circumstance in HIV-infected patients who had relatively preserved immune function on highly active antiretroviral therapy (HAART. Histopathology showed relatively advanced cancers at diagnosis with a high percentage of non transitional cell carcinoma (TCC tumor and of TCC with squamous differentiation, suggesting a potential role for human papilloma virus (HPV co-infection. Death rate was high in this population. Conclusions: Bladder cancers in HIV-infected patients remain rare but occur in relatively young HIV-infected patients with a low CD4 nadir, presenting with haematuria, most of them being smokers, and have aggressive pathological features that are associated with

  19. Model of Care for Adolescents and Young Adults with Cancer: The Youth Project in Milan.

    Science.gov (United States)

    Magni, Chiara; Veneroni, Laura; Silva, Matteo; Casanova, Michela; Chiaravalli, Stefano; Massimino, Maura; Clerici, Carlo Alfredo; Ferrari, Andrea

    2016-01-01

    Adolescents and young adults (AYA) with cancer form a particular group of patients with unique characteristics, who inhabit a so-called "no man's land" between pediatric and adult services. In the last 10 years, the scientific oncology community has started to pay attention to these patients, implementing dedicated programs. A standardized model of care directed toward patients in this age range has yet to be developed and neither the pediatric nor the adult oncologic systems perfectly fit these patients' needs. The Youth Project of the Istituto Nazionale Tumori in Milan, dedicated to AYA with pediatric-type solid tumors, can be seen as a model of care for AYA patients, with its heterogeneous multidisciplinary staff and close cooperation with adult medical oncologists and surgeons. Further progress in the care of AYA cancer patients is still needed to improve their outcomes. PMID:27606308

  20. Model of Care for Adolescents and Young Adults with Cancer: The Youth Project in Milan

    Science.gov (United States)

    Magni, Chiara; Veneroni, Laura; Silva, Matteo; Casanova, Michela; Chiaravalli, Stefano; Massimino, Maura; Clerici, Carlo Alfredo; Ferrari, Andrea

    2016-01-01

    Adolescents and young adults (AYA) with cancer form a particular group of patients with unique characteristics, who inhabit a so-called “no man’s land” between pediatric and adult services. In the last 10 years, the scientific oncology community has started to pay attention to these patients, implementing dedicated programs. A standardized model of care directed toward patients in this age range has yet to be developed and neither the pediatric nor the adult oncologic systems perfectly fit these patients’ needs. The Youth Project of the Istituto Nazionale Tumori in Milan, dedicated to AYA with pediatric-type solid tumors, can be seen as a model of care for AYA patients, with its heterogeneous multidisciplinary staff and close cooperation with adult medical oncologists and surgeons. Further progress in the care of AYA cancer patients is still needed to improve their outcomes. PMID:27606308

  1. Childhood body mass index and the risk of prostate cancer in adult men

    DEFF Research Database (Denmark)

    Aarestrup, J; Gamborg, M; Cook, M B;

    2014-01-01

    BACKGROUND: Prostate cancer aetiology is poorly understood. It may have origins early in life; previously we found a positive association with childhood height. The effects of early life body mass index (BMI; kg m(-2)) on prostate cancer remain equivocal. We investigated if childhood BMI...... to the Danish Cancer Registry. Cox proportional hazards regressions were performed. RESULTS: Overall, 3355 men were diagnosed with prostate cancer. Body mass index during childhood was positively associated with adult prostate cancer. The hazard ratio of prostate cancer was 1.06 (95% confidence interval (CI): 1.......01-1.10) per BMI z-score at age 7, and 1.05 (95% CI: 1.01-1.10) per BMI z-score at age 13. Estimates were similar and significant at all other ages. However, adjustment for childhood height attenuated the associations at all but the youngest ages as most estimates became nonsignificant. CONCLUSIONS...

  2. Gender differences among young adult cancer patients: a study of blogs.

    Science.gov (United States)

    Kim, Bora; Gillham, David

    2015-01-01

    The Internet has increasing relevance and practical use as a tool to support cancer care. For example, health support Web sites are now widely used to connect specific groups of patients who may otherwise have remained isolated, and understanding their health-related online behaviors will help in the development of more effective health support Web sites. This article examined blogs written by young adults affected by cancer and in particular examined the gender differences in these blog entries through content analysis. The results showed there is little difference in blog content between genders. This suggests that the blog environment could lessen the gender-typical behaviors often expected by society and may provide an outlet for young adult cancer patients to more freely share their cancer-related experiences, at the same time providing an opportunity for social connection. This is particularly significant for male patients who are known to inhibit their emotions as well as the expression of their health concerns.

  3. GREAT PROMISE OF TISSUE-RESIDENT ADULT STEM/PROGENITOR CELLS IN TRANSPLANTATION AND CANCER THERAPIES

    OpenAIRE

    Mimeault, Murielle; Batra, Surinder K.

    2012-01-01

    Recent progress in tissue-resident adult stem/progenitor cell research has inspired great interest because these immature cells from your own body can act as potential, easily accessible cell sources for cell transplantation in regenerative medicine and cancer therapies. The use of adult stem/progenitor cells endowed with a high self-renewal ability and multilineage differentiation potential, which are able to regenerate all the mature cells in the tissues from their origin, offers great prom...

  4. Treatment of Metastatic Prostate Cancer in Older Adults.

    Science.gov (United States)

    Loh, Kah Poh; Mohile, Supriya G; Kessler, Elizabeth; Fung, Chunkit

    2016-10-01

    The aging of the population, along with rising life expectancy, means that increasing numbers of older men will be diagnosed with prostate cancer, and a large proportion of these men will present with metastatic disease. In this paper, we discuss recent advances in prostate cancer treatment. In particular, we review management approaches for older patients with metastatic prostate cancer based on the decision tree developed by the International Society of Geriatric Oncology, which categorized older men as "fit," "vulnerable," and "frail" according to comprehensive geriatric assessment. PMID:27586377

  5. Perceptions of Cancer Risk and Cause of Cancer Risk in Korean Adults

    OpenAIRE

    Kye, Su Yeon; Park, Eun Young; Oh, Kyounghee; Park, Keeho

    2014-01-01

    Purpose The aims of the present study were to assess the prevalence of perceived risk for cancer; to explore associations between sociodemographics and family history of cancer and perceived cancer risk; to identify perceived cause of cancer risk; and to examine the associations between sociodemographics and family history of cancer and perceived cause of cancer risk. Materials and Methods This cross-sectional study was conducted among 1,009 participants aged 30-69 years, selected from a popu...

  6. Comprehension of Internet-based numeric cancer information by older adults.

    Science.gov (United States)

    Donelle, Lorie; Hoffman-Goetz, Laurie; Gatobu, Sospeter; Arocha, Jose F

    2009-12-01

    Competency in health numeracy is essential in understanding risk about disease susceptibility and the consequences of disease treatment. Both health literacy and skill in using the Internet to obtain health information are lower among older compared with younger adults. Presentation format of health information has been shown to influence comprehension. The objective of this study was to determine the influence of information formatting (text and graphic) on older adults' comprehension of Internet-based numeric cancer risk information. This cross-sectional study involved a convenience sample of adults, aged 50 years and older from diverse ethnic and educational backgrounds. Cancer risk information, obtained from a Canadian Cancer Society web page, was presented as text, graphics or as a combination of text and graphics formats. Comprehension of the information was assessed by six questions focused on basic numeracy skill and ability to perform simple calculations and operations. A three-item general context numeracy and an eight-item health context numeracy instrument were used to describe health numeracy skills of participants. The six-item Newest Vital Sign (NVS) test was used to assess prose and numeric health literacy. There was no statistically significant effect of presentation format on participants' comprehension of the cancer information. Participants' comprehension of basic health numeracy information was positively correlated with education (p numeric risk information was not a significant factor in the comprehension of cancer risk information in this group of ethnically diverse, older adults. However, comprehension of the information was related to health literacy skill and income.

  7. Yoga in adult cancer: an exploratory, qualitative analysis of the patient experience

    OpenAIRE

    McCall, Marcy; Thorne, Sally; Ward, Alison; Heneghan, Carl

    2015-01-01

    Background Some patients receiving treatment in conventional health care systems access therapeutic yoga outside their mainstream care to improve cancer symptoms. Given the current knowledge gap around patient preferences and documented experiences of yoga in adult cancer, this study aimed to describe patient-reported benefits, barriers and characteristics of programming for yoga practice during conventional treatment. Methods In depth semi-structured interviews (n = 10) were conducted in men...

  8. Enhancing Psychosocial Outcomes for Young Adult Childhood CNS Cancer Survivors: Importance of Addressing Vocational Identity and Community Integration

    Science.gov (United States)

    Strauser, David R.; Wagner, Stacia; Wong, Alex W. K.

    2012-01-01

    The purpose of this study was to examine the relationship between vocational identity, community integration, positive and negative affect, and satisfaction with life in a group of young adult central nervous system (CNS) cancer survivors. Participants in this study included 45 young adult CNS cancer survivors who ranged in age from 18 to 30 years…

  9. csrA Inhibits the Formation of Biofilms by Vibrio vulnificus▿

    OpenAIRE

    Jones, Melissa K.; Warner, Elizabeth B.; Oliver, James D.

    2008-01-01

    PCR screening of the shellfish-borne pathogen Vibrio vulnificus revealed csrA-negative strains, and these strains formed increased biofilm compared to csrA-positive strains. Complementation in trans with csrA resulted in reduced biofilm formation, similar to that by csrA+ strains. Our results provide evidence that csrA inhibits biofilm formation in V. vulnificus.

  10. HIRFL-CSR internal target system

    International Nuclear Information System (INIS)

    The structure and the design of the HIRFL-CSR internal target system is reported. The HIRFL-CSR internal target can operate in two modes: cluster target mode and polarized target mode. The cluster target may provide the gas target of H2, N2, noble gases and small molecular gases with a density of ≥ 1013 atoms/cm2, and the polarized target may provide polarized H and D beams with a density of about 2 x 1011 atoms/cm2. The target polarization is expected to be +0.90/-0.90 for hydrogen beam, and the vector polarization is expected to +0.95/-0.95 for deuterium beam

  11. Electron cooling performance at HIRFL-CSR

    International Nuclear Information System (INIS)

    In order to investigate the one-dimensional beam ordering in HIRFL-CSR, the ion beam of 58Ni19+ with the energy of 6.39 MeV/u was accumulated in the main ring of HIRFL-CSR with the help of electron cooling. The maximum accumulated ion beam intensity in the 10 seconds was measured, and the lifetime of ion beams was measured. The momentum spread of the ion beam varying with the particle number was measured during the ion beam decay, the power exponent was derived from these data, in additional, the momentum spread in the case of a constant particle number was plotted with the angle between ion and electron beams and electron beam profile. The oscillation and shift of the central frequency of the ion beam were observed during the experiments when the angle was large. (authors)

  12. Vliv CSR aktivit na reputaci firmy

    OpenAIRE

    Oberreiter, Štěpán

    2008-01-01

    Hlavním cílem této bakalářské práce je posouzení vlivu CSR(Corporate Social Responsibility-do čestiny přeloženo jako společenská odpovědnost firem) na reputaci firmy. V práci krátce představím historický vývoj CSR, současný stav a přiblíží též různé metody měření těchto aktivit. Dalším cílem práce je posoudit, jestli se jedná v případě těchto aktivit o náklad, či o investici.

  13. Assessing cognitive function and capacity in older adults with cancer.

    Science.gov (United States)

    McKoy, June M; Burhenn, Peggy S; Browner, Ilene S; Loeser, Kari L; Tulas, Katrina M; Oden, Megan R; Rupper, Randall W

    2014-01-01

    The number of older individuals with cancer is increasing exponentially, mandating that oncologists contemplate more comprehensive and multidisciplinary approaches to treatment of this cohort. Recruitment of assessment instruments validated in older patients can be invaluable for guiding treatment and decision-making by both patients and providers, and can arguably contribute to improving outcomes and health-related quality of life. The Comprehensive Geriatric Assessment is one such validated instrument that can be used by oncologists to assess patient readiness and appropriateness for prescribed cancer therapy. As a multidisciplinary diagnostic and treatment process, it comprises functional status, cognitive status, social support, and advance care preferences, and is an ideal instrument for evaluating complex older individuals. It is well established that many older individuals with cancer travel with multiple comorbid illnesses, including cognitive impairment, and when presented with a cancer diagnosis struggle to choose from multiple treatment options. In addition to the complete medical history, the ability of patients to decide on a course of therapy in concert with their oncologist is critically important. Alternatively, many oncologists are conflicted as to whether true informed consent for treatment can be obtained from many older patients. Having a roadmap to decision-making capacity is therefore an inescapable imperative in geriatric oncology, because careful attention must be directed at identifying older patients with cancer who might benefit from these assessments and the individualized treatment plans that emerge. PMID:24453297

  14. Welfare mix, CSR and social citizenship

    OpenAIRE

    Moreno Fernández, Luis

    2010-01-01

    Corporate Social Responsibility (CSR) is an important undertaking by corporations in order to advance social citizenship. In the last decades a growing implication of businesses and NGOs in welfare development has run hand in hand with a noticeable increase of both: (a) the for-profit welfare provision of policies and services to the general public, and (b) those programmes made available by corporations to their employees. All these developments, together with the provision of social poli...

  15. CSR in International Business - Creating Shared Value

    OpenAIRE

    Fjell, Lise; Rødland, Silje Erdal

    2015-01-01

    The world is experiencing several global issues of economic, social, cultural, and humanitarian characters, and they are continuously increasing in scale. Multinational corporations (MNCs) are considered as both contributors to the problems, but also as a big part of the solutions. Consequently, the pressure put on firms to take responsibility for their actions is increasing, and corporate social responsibility (CSR) has emerged as an inescapable priority for managers. However, MNCs investme...

  16. Corporate Social Responsibility (CSR) and energy industry

    International Nuclear Information System (INIS)

    What means Corporate Social Responsibility (CSR) in the energy industry? A rising energy demand with limited natural resources pose utilities, industry and consumers with new challenges. This book follows an interdisciplinary approach and for the first time brings together debates and findings from industry, science, politics, culture and media. Because the energy transition can only succeed if it is comprehensible for the individual and fragmented perspectives and interests are merged.

  17. HIRFL-CSR electron cooling system

    International Nuclear Information System (INIS)

    Electron cooling technique will be applied to the proposed Lanzhou heavy ion cooler-storage ring (HIRFL-CSR). A electron cooling device with a maximum electron energy of 165 keV and maximum current density of 0.244 A/cm2 is planned to cool heavy ions up to energies of 300 MeV/u. The preliminary design for the cooling system is presented

  18. Animal Welfare: A Dilemma for Japanese CSR?

    OpenAIRE

    Mizuta, Wakako

    2010-01-01

    ABSTRACT This paper seeks to analyse whether animal welfare issues can be one of concerns for Japanese companies to formulate CSR strategy. Today, the subject of animal welfare is becoming one of important global issues since European Union regulates the issues and its regulations are becoming stricter. Japanese companies would face on the issues in the EU and global market. However, since there is distinct public concern for the issues in Japan, it is questionable if and how Japanese com...

  19. CSR - nejen zelený reporting

    OpenAIRE

    Trunkát, Michal

    2011-01-01

    The topic of this diploma thesis is a Corporate Social Responsibility concept. The thesis is primarily focused on Corporate social responsibility reporting of companies located in the Czech Republic which is nowadays based on voluntary approach. The author compares CSR reports with GRI standards that currently represent respected framework for responsible reporting. The primary aim of GRI with assistance of G3 guidelines is to create unified, compact and transparent directions for GRI reporti...

  20. The Economic Virtues of SRI and CSR

    OpenAIRE

    Derwall, Jeroen

    2007-01-01

    textabstractFinancial markets and company managers are increasingly acknowledging the concepts of socially responsible investing (SRI) and corporate social responsibility (CSR), but not without reservations. These hesitations are largely attributable to ongoing debates about a potential conflict between social responsibility goals and the traditional financial objectives of investors and companies. This thesis bundles six empirical studies that deepen our understanding of the economic value o...

  1. HIRFL-CSR internal cluster target

    Science.gov (United States)

    Shao, Caojie; Lu, Rongchun; Cai, Xiaohong; Yu, Deyang; Ruan, Fangfang; Xue, Yingli; Zhang, Jianming; Torpokov, D. K.; Nikolenko, D.

    2013-12-01

    Since HIRFL-CSR internal cluster target was built, it has played a key role in in-ring experiments at HIRFL-CSR. So far it have been operated with five gas species as targets for scattering experiments, i.e. hydrogen, nitrogen, argon, neon, and krypton. The obtained highest thickness for hydrogen target amounts up to 1012 atoms/cm2, and those of other targets are larger than 1013 atoms/cm2 with the background pressure of 10-11 mbar in CSR. The target thickness can be varied by regulating the nozzle temperature and pressure of the inlet gas. The first online internal target experiment dedicated to investigate radioactive electron capture (REC) process with Xe54+ ions colliding with the nitrogen target demonstrated the stability and reliability of the internal target system. In addition, hydrogen and krypton were also tested online in recent experiments, which indicate the target system can meet experimental requirements for the thickness of target, pressure in scattering chamber, and long-term stability.

  2. CSR in the Aftermath of the Financial Crisis

    DEFF Research Database (Denmark)

    Lauesen, Linne Marie

    2013-01-01

    of Schwartz and Carroll’s ‘Three-­domain CSR-­model’, which the Principle extends and revises to: Economy, L/Egal, Environment, and Ethics. This Principle disentangles the dialectic relationship between economic and social responsibility; takes financial products into a consideration; refines the definitions......Purpose – The purpose of the paper is to examine the literature of CSR before and in the aftermath of the financial crisis in 2008. The aim of the research question is to map out the consequences upon CSR derived from the crisis and to derive new principles of future CSR models to come consistent...... with the consequences of the financial crisis, and to suggest new research as well as policy-­‐making possibilities to highlight the importance and necessary survival of CSR as an instrument for sustainable and financial progress. Design/methodology/approach – The paper uses a literature review of CSR prior...

  3. CSR in the Aftermath of the Financial Crisis

    DEFF Research Database (Denmark)

    Lauesen, Linne Marie

    2013-01-01

    's “Three-domain CSR-model”, which the Principle extends and revises to: Economy, L/Egal, Environment, and Ethics. This Principle disentangles the dialectic relationship between economic and social responsibility; takes financial products into consideration; refines the definitions of good stakeholder......Purpose – The purpose of this paper is to examine the literature of CSR before and in the aftermath of the financial crisis in 2008. The aim of the research question is to map out the consequences upon CSR derived from the crisis and to derive new principles of future CSR models to come consistent...... with the consequences of the financial crisis, and to suggest new research as well as policy-making possibilities to highlight the importance and necessary survival of CSR as an instrument for sustainable and financial progress. Design/methodology/approach – This paper uses a literature review of CSR prior to and after...

  4. Intragenic recombination in the CSR1 locus of Arabidopsis.

    Science.gov (United States)

    Mourad, G; Haughn, G; King, J

    1994-04-01

    Four classes of herbicides are known to inhibit plant acetolactate synthase (ALS). In Arabidopsis, ALS is encoded by a single gene, CSR1. The dominant csr1-1 allele encodes an ALS resistant to chlorsulfuron and triazolopyrimidine sulfonamide while the dominant csr1-2 allele encodes an ALS resistant to imazapyr and pyrimidyl-oxy-benzoate. The molecular distance between the point mutations in csr1-1 and csr1-2 is 1369 bp. Here we used multiherbicide resistance as a stringent selection to measure the intragenic recombination frequency between these two point mutations. We found this frequency to be 0.008 +/- 0.0028. The recombinant multiherbicide-resistant allele, csr1-4, provides an ideal marker for plant genetic transformation. PMID:8177214

  5. CSR jako przedsięwzięcie biznesowe

    Directory of Open Access Journals (Sweden)

    Szymon Wierciński

    2011-04-01

    Full Text Available Niniejszy artykuł poświęcony jest relacji między programami społecznej odpowiedzialności biznesu a wynikami finansowymi organizacji (CSR – CFP. Podążając za nurtem badaczy poszukujących biznesowego uzasadnienia dla CSR, autor przedstawia problemy i wyzwania stojące przed menedżerami i naukowcami, dotyczące mierzenia efektywności programów CSR. Przegląd literatury prowadzi do zwrócenia szczególnej uwagi na problem związany z precyzyjnym mierzeniem wpływu CSR na różnych poziomach organizacji i propozycji sklasyfikowania działań CSR na podstawie ich efektywności, celem usprawnienia i rozwijania programów CSR w kierunku wspólnych korzyści społeczno-biznesowych.

  6. Sex-specific associations between birth weight and adult primary liver cancer in a large cohort of Danish children

    DEFF Research Database (Denmark)

    Zimmermann, Esther; Berentzen, Tina L; Gamborg, Michael;

    2016-01-01

    Whether the prenatal period is critical for the development of adult primary liver cancer (PLC) is sparsely investigated. Recently, attention has been drawn to potential sex-differences in the early origins of adult disease. We investigated the association between birth weight and adult PLC...

  7. Cancer incidence and mortality trends in Australian adolescents and young adults, 1982–2007

    Directory of Open Access Journals (Sweden)

    Haggar Fatima A

    2012-04-01

    Full Text Available Abstract Background Increasing incidence and lack of survival improvement in adolescents and young adults (AYAs with cancer have led to increased awareness of the cancer burden in this population. The objective of this study was to describe overall and type-specific cancer incidence and mortality trends among AYAs in Western Australia from 1982–2007. Methods Age–adjusted incidence and mortality rates were calculated for all malignancies combined and for each of the most common diagnostic groups, using five-year age–specific rates. Joinpoint regression analysis was used to derive annual percentage changes (APC for incidence and mortality rates. Results The annual incidence rate for all cancers combined increased in males from 1982 until 2000 (APC = 1.5%, 95%CI: 0.9%; 2.1% and then plateaued, whilst rates for females remained stable across the study period (APC = −0.1%; 95%CI: −0.2%; 0.4% across the study period. For males, significant incidence rate increases were observed for germ cell tumors, lymphoblastic leukemia and thyroid cancer. In females, the incidence of Hodgkin’s lymphoma, colorectal and breast cancers increased. Significant incidence rate reductions were noted for cervical, central nervous system and lung cancers. Mortality rates for all cancers combined decreased from 1982 to 2005 for both males (APC = −2.6%, 95%CI:−3.3%;−2.0% and females (APC = −4.6%, 95%CI:−5.1%;−4.1%. With the exception of bone sarcoma and lung cancer in females, mortality rates for specific cancer types decreased significantly for both sexes during the study period. Conclusions Incidence of certain AYA cancers increased, whilst it decreased for others. Mortality rates decreased for most cancers, with the largest improvement observed for breast carcinomas. Further research is needed to identify the reasons for the increasing incidence of certain cancers.

  8. Materiality Analysis for CSR Reporting in Spanish SMEs

    OpenAIRE

    Elena Escrig-Olmedo; Raul Leon-Soriano; Juana Maria Rivera-Lirio; Maria Angeles Fernandez-Izquierdo; Maria Jesus Muñoz-Torres,; Idoya Ferrero-Ferrero

    2013-01-01

    Most corporate social responsibility (CSR) standards have not been designed to be implemented in small and medium sized enterprises (SMEs). Given that 99% of Spanish companies are SMEs, this study aims to propose a selection of basic CSR material issues that, because of their usefulness and significance, should be adapted to Spanish SMEs and their stakeholders. This study provides a CSR model for SMEs that includes the most important social, environmental, and corporate governance issues. Thi...

  9. CSR and market changing product innovations: Indian case studies

    OpenAIRE

    Ramani, S.V.; Mukherjee, V.

    2010-01-01

    Do firms need to sacrifice profit while innovating in order to further social objectives, as corporate social responsibility (CSR) would seem to suggest? To answer this question, the paper compiles a classification of innovations according to market impact and CSR potential. Then it details case studies of two market changing (MC) innovations in India: genetically modified cotton of Monsanto and a drugs cocktail for HIV/AIDS of Cipla. It demonstrates that the CSR potential of an MC innovation...

  10. Problems and Prospects of CSR System Development in China

    OpenAIRE

    Jie Wang; Sheng Qin; Yanjuan Cui

    2010-01-01

    Corporate Social Responsibility (CSR) reporting system is the system to disclosure the institutions andorganizations influence on the environment, economy and society to the public. It is a great improvement of CSRthat has been issued by advanced enterprises. However the CSR development is still unbalance in China, half ofthem are in the initial stage. The whole level of CSR is not high and the disclosure breadth and depth are notdeep to cover the stakeholder requirements and corporate value....

  11. Towards a convergent institutional perspective on corporate social responsibility (CSR)

    OpenAIRE

    Blindheim, Bjørn-Tore

    2010-01-01

    The research reported in this thesis has been directed by three interconnected questions: 1) How can institutional theory contribute to our understanding of the contingent nature of CSR and manifestations of CSR within national-level fields? 2) What are the potential institutional and political implications of CSR? and 3) How can institutional theory contribute to discussions of a justified foundation for companies (political) efforts on the societal arena? Since the 1950...

  12. Why Enforcing Corporate Social Responsibility (CSR) is Morally Questionable

    OpenAIRE

    Masaka, Dennis

    2008-01-01

    Docketed literature on Corporate Social Responsibility (CSR) exhibits heated contentions on the nature of business-society relations. This paper seeks to explore this contentious issue in the light of contemporary incorporation of CSR in business strategic plans. It notes that enforcing CSR on business might lead to its manipulation to advance corporate organisations’ purely self-interested ends rather than pursuing intrinsic philanthropic activities for the good of society. An insig...

  13. The role and dynamics of CSR in Swiss SMEs.

    OpenAIRE

    Looser, Stéphanie

    2016-01-01

    Corporate Social Responsibility (CSR) frameworks worldwide have been dominated by the concerns and needs of large companies whose highly formalised CSR management systems often failed in previous years to prevent anti-social and illegal behaviour. Thus, there is growing interest in informal processes, relationships and organisational cultures – and corresponding business models – that embed and exemplify CSR. It is proposed that detailed study of Small and Medium-sized Enterprises (SMEs) with...

  14. HUBUNGAN CORPORATE SOCIAL RESPONSIBILITY (CSR) DENGAN KINERJA PERUSAHAAN

    OpenAIRE

    Sundari, Sri

    2015-01-01

    Corporate Social Responsibility (CSR) is the company's commitment to participate in the sustainable economic development to improve the quality of life and environmental benefits the company itself, local community, and society in general. CSR is an important element for the success of the company and can provide benefits to the company. The Company will endeavor to carry out CSR activities that will contribute to internal and external stakeholders. Companies that have a high social performan...

  15. Consumer reactions to different forms of CSR communication

    OpenAIRE

    Buden, Ivana; Connett, Louise

    2016-01-01

    Aim Companies around the world are making sizeable investments into CSR initiatives, but ensuring appropriate returns on these investments remains challenging. Therefore, it is of value to study the communication of corporate CSR efforts. The purpose of this study is to investigate how consumers react to rational versus emotional message strategies in CSR communication. Two categories of consumer reactions were considered: trust and purchase intention. Methods Qualitative research with four f...

  16. Pengaruh Implementasi Corporate Social Responsibility (CSR) terhadap Profitabilitas Perusahaan Perkebunan

    OpenAIRE

    Barus, Riantri

    2015-01-01

    Corporate Social Responsibility (CSR) can be defined as a business organization responsible for the impact of their activities on customers, suppliers, employees, shareholders, communities and other stakeholders as well as the environment, which is known as the triple bottom line (profit, planet and people). However, there are many companies implemented their CSR only on public assistance programs and not integrated with the company's core business. Theoretically, if company doing their CSR a...

  17. CSR aktivity ve vybrané firmě

    OpenAIRE

    Vlková, Petra

    2013-01-01

    The aim of this thesis is to evaluate the CSR strategy of the company Vaisala, together with its existing CSR activities, and to identify opportunities for modification of this strategy and these activities. Vaisala is a global leader in environmental and industrial measurement operating worldwide. Furthermore, this thesis answers the research question on whether Vaisala's activities within its CSR strategy are currently sufficient. The paper is divided into three main chapters. The first cha...

  18. Determinants of corporate social responsibility (CSR). Implementation in companies

    OpenAIRE

    Chodyński, Andrzej; Huszlak, Wojciech

    2014-01-01

    Praca recenzowana / peer-reviewed paper Growing number of businesses are incorporating social responsibility (CR) into their strategy. Businesses notice a number of benefits of CSR implementation. In the literature, there is lack of knowledge regarding the circumstances and conditions affecting CSR implementation. The aim of the present article is to attempt to determine the conditions affecting successful implementation of CSR in companies. The research method which we used is...

  19. CSR Driven Brand Marketing: The Case of Toms

    OpenAIRE

    Mensah, Doris

    2016-01-01

    This research investigates the concept of Corporate Social Responsibility and Branding and how organizations can integrate CSR initiatives with strategic brand management. The project analyzed and discussed Toms Group CSR activities in West Africa more especially in Ghana in relation to child labor and the conditions of cocoa farmers and what the company is doing in terms of CSR strategy that can benefit the brand of the company. The study empirically made semi-structured interviews with t...

  20. RESPONSIBLE BEHAVIOUR OR BUSINESS? SOCIAL RESPONSIBILITY (CSR) IN SPORT MANAGEMENT

    OpenAIRE

    Molnar, G.; Rathonyi-Odor, K.; Borbely, Akos

    2013-01-01

    CSR has become increasingly important in today’s business world and managers must consider not only the economic results of their decisions but also the legal, ethical, moral, and social impact and repercussions of each of their decisions. Some multinational companies’ CSR activities even clearly represent applicability of CSR in sport management. The aim of this study was to do a critical comparative analysis, present the changes, alterations in the traditional company philosophy, object...

  1. CSR BALANCED SCORECARD SYSTEMS AND BUSINESS PERFORMANCES: SMEs CASE STUDY

    OpenAIRE

    Edward Sek Khin Wong; Rusnah Muhamad; Lau Wee Yeap

    2016-01-01

    This paper aims to examine the performance measurement using the CSR Balanced Scorecard system in SMEs firms in Malaysia. It investigates the relationships of the four perspectives of CSR Balanced Scorecard system toward performance measurement. The purpose of this paper is to in- vestigate whether or not the improvement of the non-financial CSR measures will lead to the im- provement of performance measures. To test these relationships, data were collected using the four perspectives approac...

  2. Determinants of voluntary CSR disclosure: Empirical evidence from Germany

    OpenAIRE

    Gamerschlag, Ramin; Möller, Klaus; Verbeeten, Frank

    2011-01-01

    textabstractCurrently, companies spend a great deal of effort on Corporate Social Responsibility (CSR) disclosures. CSR disclosure relates to the provision of information on companies' environmental and social performance. From an economic perspective, companies might disclose this information to avoid or decrease potential political costs. We construct a CSR disclosure index based on the Global Reporting Initiative (GRI) guidelines. Using content analysis, we analyze 130 listed German compan...

  3. Strategic CSR Innovation - Serving Societal and Individual Needs

    OpenAIRE

    Midttun, Atle

    2009-01-01

    This report explores the challenges and opportunities of strategic CSR, and is primarily based on three cases of CSR-driven innovation in Norway. The study has been undertaken within the framework of a project on CSR-driven innovation organised and partially financed by the Nordic Innovation Centre and carried out by the business schools in the four Nordic capitals. Copenhagen Business School; BI – Norwegian School of Management, Helsinki School of Economics, Reykjavik Business University, St...

  4. Yoga for Health-Related Quality of Life in Adult Cancer: A Randomized Controlled Feasibility Study

    Directory of Open Access Journals (Sweden)

    Marcy McCall

    2015-01-01

    Full Text Available An increase in patient-led uptake of complementary therapies in adult cancer has led to a need for more rigorous study of such interventions and their outcomes. This study therefore aimed to evaluate the feasibility and acceptability of a yoga intervention in men and women receiving conventional treatment for a cancer diagnosis. Prospective, mixed methods feasibility trial allocated participants to receive one of three yoga interventions over a four-week study period. Data collection was completed through online survey of QOL-CA/CS and customized surveys. Fifteen participants were included (11 female undergoing treatment for breast, prostate, colorectal, brain, and blood and lung cancer. Two participants dropped out and complete qualitative and quantitative data sets were collected from 12 participants and four yoga instructors. Other outcome measures included implementation costs patient-reported preferences for yoga intervention and changes in QOL-CA/CS. Three types of yoga intervention were safely administered in adult cancer. Mixed methods, cost-efficiency, QOL-CA/CS, and evidence-based design of yoga intervention have been used to establish feasibility and patient-preferences for yoga delivery in adult caner. Results suggest that, with some methodological improvements, a large-scale randomized controlled trial is warranted to test the efficacy of yoga for male and female cancer patients. This trial is registered with Clinicaltrials.gov NCT02309112.

  5. Incidence and Treatment Abandonment in Teen And Young Adult Cancers

    Directory of Open Access Journals (Sweden)

    Prakash Chitalkar

    2016-03-01

    Results- On analyzing data of three years ,hematolymphoid malignancy(28% cases are the most common cases seen followed by Breast (10% and head and neck (10%,cervix(6%,CNS(5% ,Bone( 4%. 38% TYA cancer patients abandoned treatment . Telephonic tracking, financial support, counseling of whole family are methods employed in reducing abandonment. [Natl J Med Res 2016; 6(1.000: 77-79

  6. Primary Care Use before Cancer Diagnosis in Adolescents and Young Adults - A Nationwide Register Study

    DEFF Research Database (Denmark)

    Ahrensberg, Jette Møller; Fenger-Grøn, Morten; Vedsted, Peter

    2016-01-01

    with cancer during 2002-2011 in the age group 15-39 years were included (N = 12,306); each participant was matched on gender, age and general practice with 10 randomly selected references (N = 123,060). The use of primary healthcare services (face-to-face contacts, blood tests and psychometric tests......) was measured during the two years preceding the diagnosis (index date), and collected data were analysed in a negative binomial regression model. RESULTS: The cases generally increased their use of primary care already from 8 months before a cancer diagnosis, whereas a similar trend was not found for controls......INTRODUCTION: Survival rates of cancer patients have generally improved in recent years. However, children and older adults seem to have experienced more significant clinical benefits than adolescents and young adults (AYAs). Previous studies suggest a prolonged diagnostic pathway in AYAs...

  7. CSR in the SuperKEKB Damping Ring

    International Nuclear Information System (INIS)

    Coherent synchrotron radiation (CSR) is generated when a bunched beam traverses a dipole magnet or a wiggler/undulator. It can degrade the beam quality in both storage rings and linacs through enhancing the beam energy spread and lengthening the bunch length, even cause single-bunch microwave instabilities. Using several methods, CSR impedances in the positron damping ring (DR) of the SuperKEKB which is under design were calculated. From the impedances due to CSR, resistive wall and various vacuum components, quasi-Green function wake potentials were constructed and used in simulations of Particle-In-Cell (PIC) tracking. We present the CSR related results in this paper.

  8. Wnt signaling in adult intestinal stem cells and cancer

    OpenAIRE

    Krausová, M. (Michaela); Kořínek, V. (Vladimír)

    2014-01-01

    Signaling initiated by secreted glycoproteins of the Wnt family regulates many aspects of embryonic development and it is involved in homeostasis of adult tissues. In the gastrointestinal (GI) tract the Wnt pathway maintains the self-renewal capacity of epithelial stem cells. The stem cell attributes are conferred by mutual interactions of the stem cell with its local microenvironment, the stem cell niche. The niche ensures that the threshold of Wnt signaling in the stem cell is kept in physi...

  9. Corporate Social Responsibility (CSR) v spoločnosti Danone a.s.

    OpenAIRE

    Petroniová, Lucia

    2009-01-01

    This thesis deals with theme Corporate Social Responsibility (CSR). Theoretical part provides a comprehensive view of CSR. After the initial definitions of CSR work continues with the historical overview of CSR performance, the benefits of implementing CSR activities, explains the concept of "stakeholders", stresses the importance of communication of CSR activities and finishes with perception of social responsibility by individuals and companies. The practical part introduces specific intern...

  10. Can a Finnish SME gain competitive advantage through strategic CSR. : in the case of Finbow Ltd.

    OpenAIRE

    Hainari-Maula, Lotta

    2015-01-01

    The thesis is researching if a Finnish small and medium-sized enterprise (SME) can gain competitive advantage through strategic corporate social responsibility (CSR). In order to give an understanding of the broad concept of CSR, the research starts with a theory section consisting of a definition of CSR, followed by a discussion of the two main differing views of CSR. Then the concept of strategic CSR is introduced, and the relation between CSR and SMEs is discussed. In the case st...

  11. Extremely low frequency electromagnetic fields (EMF) and brain cancer in adults and children: review and comment.

    Science.gov (United States)

    Gurney, J. G.; van Wijngaarden, E.

    1999-01-01

    Epidemiologic and experimental research on the potential carcinogenic effects of extremely low frequency electromagnetic fields (EMF) has now been conducted for over two decades. Cancer epidemiology studies in relation to EMF have focused primarily on brain cancer and leukemia, both from residential sources of exposure in children and adults and from occupational exposure in adult men. Because genotoxic effects of EMF have not been shown, most recent laboratory research has attempted to show biological effects that could be related to cancer promotion. In this report, we briefly review residential and occupational EMF studies on brain cancer. We also provide a general review of experimental studies as they relate both to the biological plausibility of an EMF-brain cancer relation and to the insufficiency of such research to help guide exposure assessment in epidemiologic studies. We conclude from our review that no recent research, either epidemiologic or experimental, has emerged to provide reasonable support for a causal role of EMF on brain cancer. PMID:11550314

  12. Appropriateness of cardiovascular care in elderly adult cancer survivors.

    Science.gov (United States)

    Cheung, Winson Y; Levin, Raisa; Setoguchi, Soko

    2013-01-01

    Research suggests that the quality of non-cancer-related care among cancer survivors (CS) is suboptimal. Secondary disease prevention is an important component of survivorship care that has not been previously evaluated. Our aims were (1) to assess the utilization of and adherence to medications and treatments for the secondary prevention of myocardial infarction (MI) in CS versus non-cancer patients (NCP) and (2) to compare temporal trends in cardiovascular care between these two patient cohorts. Linking data from Medicare, pharmacy assistance programs, and cancer registries, we calculated the percentage of individuals receiving preventive medications (statins, β-blockers, angiotensin-converting enzyme inhibitors) and revascularization interventions (angioplasty, stent, bypass surgery) within 90 days after acute MI in CS and propensity score-matched NCP. We assessed trends over time and determined predictors of appropriate preventive care using modified Poisson regression. We identified 1,119 CS and 7,886 NCP. Compared to NCP, more survivors received statins (38 vs. 31 %) and β-blockers (67 vs. 59 %), but fewer underwent bypass surgery (1.5 vs. 2.8 %) after MI. From 1997 to 2004, both survivors and NCP were increasingly prescribed medications to prevent future coronary events. Over the same time period, receipt of bypass surgery was significantly lower among survivors. Co-morbidities, such as depression and lung disease, and demographic factors, such as advanced age and female, were associated with underuse of preventive care among survivors when compared to NCP. Use of preventive medications and procedures has generally improved, but uptake of bypass surgery among CS still lags behind NCP.

  13. Understanding Cancer Prognosis

    Medline Plus

    Full Text Available ... Services Advance Directives Using Trusted Resources Cancer Types Adolescents and Young Adults with Cancer Reports, Research, and ... of Cancers Cancers by Body Location Childhood Cancers Adolescent & Young Adult Cancers Metastatic Cancer Recurrent Cancer Research ...

  14. Post-Transcriptional Regulation by the Csr Global Regulatory System in Escherichia coli

    OpenAIRE

    Suzuki, Kazushi; 鈴木, 一史

    2007-01-01

    In many species of bacteria, the Csr (carbon storage regulator) global regulatory system coordinates the expression of various genes. In Escherichia coli, the central component of this system, CsrA, is a RNA-binding protein. The CsrA is a homodimer and binds to leader segments of target mRNAs, affecting their translation and stability. CsrA activity is regulated by two small non-coding RNAs, CsrB and CsrC. These RNAs contain multiple CsrA-binding sequences and act by sequestering CsrA. In thi...

  15. Establishment of CSR Matter-Element Evaluation Model in Perspective of Low Carbon Economy in China

    Directory of Open Access Journals (Sweden)

    Li Furong

    2013-06-01

    Full Text Available With the development of CSR concept, more and more enterprises begin to bring CSR into practice. Especially in the era of low-carbon economy develops quickly, CSR practice is going to mature. In order to make a scientific evaluation on CSR and promote the comprehensive development of CSR, this study develop a new CSR evaluation model under requires of low-carbon economy development. This CSR evaluation model combined G1 weighting method with the Matter-Element Model and finally verified by an example. What we do in this study will provide a good guidance for the development of CSR evaluation and practices.

  16. Cancer and non-cancer health effects from food contaminant exposures for children and adults in California: a risk assessment

    Directory of Open Access Journals (Sweden)

    Vogt Rainbow

    2012-11-01

    Full Text Available Abstract Background In the absence of current cumulative dietary exposure assessments, this analysis was conducted to estimate exposure to multiple dietary contaminants for children, who are more vulnerable to toxic exposure than adults. Methods We estimated exposure to multiple food contaminants based on dietary data from preschool-age children (2–4 years, n=207, school-age children (5–7 years, n=157, parents of young children (n=446, and older adults (n=149. We compared exposure estimates for eleven toxic compounds (acrylamide, arsenic, lead, mercury, chlorpyrifos, permethrin, endosulfan, dieldrin, chlordane, DDE, and dioxin based on self-reported food frequency data by age group. To determine if cancer and non-cancer benchmark levels were exceeded, chemical levels in food were derived from publicly available databases including the Total Diet Study. Results Cancer benchmark levels were exceeded by all children (100% for arsenic, dieldrin, DDE, and dioxins. Non-cancer benchmarks were exceeded by >95% of preschool-age children for acrylamide and by 10% of preschool-age children for mercury. Preschool-age children had significantly higher estimated intakes of 6 of 11 compounds compared to school-age children (p Conclusions Dietary strategies to reduce exposure to toxic compounds for which cancer and non-cancer benchmarks are exceeded by children vary by compound. These strategies include consuming organically produced dairy and selected fruits and vegetables to reduce pesticide intake, consuming less animal foods (meat, dairy, and fish to reduce intake of persistent organic pollutants and metals, and consuming lower quantities of chips, cereal, crackers, and other processed carbohydrate foods to reduce acrylamide intake.

  17. Survivorship services for adult cancer populations: a pan-Canadian guideline

    Science.gov (United States)

    Howell, D.; Hack, T.F.; Oliver, T.K.; Chulak, T.; Mayo, S.; Aubin, M.; Chasen, M.; Earle, C.C.; Friedman, A.J.; Green, E.; Jones, G.W.; Jones, J.M.; Parkinson, M.; Payeur, N.; Sabiston, C.M.; Sinclair, S.

    2011-01-01

    Objective Our goal was to develop evidence-based recommendations for the organization and structure of cancer survivorship services, and best-care practices to optimize the health and well-being of post–primary treatment survivors. This review sought to determine the optimal organization and care delivery structure for cancer survivorship services, and the specific clinical practices and interventions that would improve or maximize the psychosocial health and overall well-being of adult cancer survivors. Data Sources We conducted a systematic search of the Inventory of Cancer Guidelines at the Canadian Partnership Against Cancer, the U.S. National Guideline Clearinghouse, the Canadian Medical Association InfoBase, medline (ovid: 1999 through November 2009), embase (ovid: 1999 through November 2009), Psychinfo (ovid: 1999 through November 2009), the Cochrane Library (ovid; Issue 1, 2009), and cinahl (ebsco: 1999 through December 2009). Reference lists of related papers and recent review articles were scanned for additional citations. Methods Articles were selected for inclusion as evidence in the systematic review if they reported on organizational system components for survivors of cancer, or on psychosocial or supportive care interventions HOWELL et al. designed for survivors of cancer. Articles were excluded from the systematic review if they focused only on pediatric cancer survivor populations or on populations that transitioned from pediatric cancer to adult services; if they addressed only pharmacologic interventions or diagnostic testing and follow-up of cancer survivors; if they were systematic reviews with inadequately described methods; if they were qualitative or descriptive studies; and if they were opinion papers, letters, or editorials. Data Extraction and Synthesis Evidence was selected and reviewed by three members of the Cancer Journey Survivorship Expert Panel (SM, TC, TKO). The resulting summary of the evidence was guided further and reviewed

  18. CSR and skepticism: the influence of fit and reputation on skepticism towards CSR communications

    NARCIS (Netherlands)

    W.J.L. Elving

    2010-01-01

    PURPOSE Consumers tend to be skeptic sometimes towards CSR outlets or communication of companies. In this experiment we tested the influence of fit and reputation on consumer skepticism when confronted with a Cause Related Marketing advertisement. DESIGN In a two (Fit versus no Fit) by three (bad re

  19. Are Older Adults Up-to-Date With Cancer Screening and Vaccinations?

    Directory of Open Access Journals (Sweden)

    Douglas Shenson, MD, MPH, MS

    2005-07-01

    Full Text Available Introduction Public health organizations in the United States emphasize the importance of providing routine screening for breast cancer, cervical cancer, and colorectal cancer, as well as vaccinations against influenza and pneumococcal disease among older adults. We report a composite measure of adults aged 50 years and older who receive recommended cancer screening services and vaccinations. Methods We analyzed state data from the 2002 Behavioral Risk Factor Surveillance System, which included 105,860 respondents aged 50 and older. We created a composite measure that included colonoscopy or sigmoidoscopy within 10 years or a fecal occult blood test in the past year, an influenza vaccination in the past year, a Papanicolaou test within 3 years for women with an intact cervix, a mammogram, and for adults aged 65 and older, a pneumonia vaccination during their lifetime. We performed separate analyses for four age and sex groups: men aged 50 to 64, women aged 50 to 64, men aged 65 and older, and women aged 65 and older. Results The percentage of each age and sex group that was up-to-date according to our composite measure ranged from 21.1% of women aged 50 to 64 (four tests to 39.6% of men aged 65 and older (three tests. For each group, results varied by income, education, race/ethnicity, insurance status, and whether the respondent had a personal physician. Conclusion These results suggest the need to improve the delivery of cancer screenings and vaccinations among adults aged 50 and older. We propose continued efforts to measure use of clinical preventive services.

  20. Unmet adolescent and young adult cancer survivors information and service needs: A population-based cancer registry study

    Science.gov (United States)

    Keegan, Theresa H.M.; Lichtensztajn, Daphne Y.; Kato, Ikuko; Kent, Erin E.; Wu, Xiao-Cheng; West, Michelle M.; Hamilton, Ann S.; Zebrack, Brad; Bellizzi, Keith M.; Smith, Ashley W.

    2012-01-01

    Purpose We described unmet information and service needs of adolescent and young adult (AYA) cancer survivors (15-39 years of age) and identified sociodemographic and health-related factors associated with these unmet needs. Methods We studied 523 AYAs recruited from 7 population-based cancer registries, diagnosed with acute lymphocytic leukemia, Hodgkin lymphoma, non-Hodgkin lymphoma, germ cell cancer or sarcoma in 2007-08. Participants completed surveys a median of 11 months from diagnosis. Multivariable logistic regression analyses were used to estimate associations between unmet (information and service) needs and sociodemographic and health-related factors. Results More than half of AYAs had unmet information needs relating to their cancer returning and cancer treatments. AYAs needing services, but not receiving them, ranged from 29% for in-home nursing to 75% for a support group. The majority of AYAs who needed a pain management expert, physical/occupational therapist, mental health worker or financial advice on paying for health care did not receive services. In multivariable analyses, older participants, men, participants of non-White race/ethnicity, and participants who reported less than excellent general health, or fair/poor quality of care were more likely to report unmet information needs. Factors associated with both unmet service and information needs included physical health or emotional problems interfering with social activities or having ≥ 3 physical treatment-related symptoms. Conclusions Recently diagnosed AYA cancer survivors have substantial unmet information needs varying by demographic and health-related factors. Implications for Cancer Survivors We identified subgroups of AYA cancer survivors with high unmet needs that can be targeted for interventions and referrals. PMID:22457219

  1. Children and young adults with parents with cancer: a population-based study

    Directory of Open Access Journals (Sweden)

    Syse A

    2012-03-01

    Full Text Available Astri Syse1, Gjøril B Aas1, Jon H Loge2,31Cancer Registry of Norway, 2Oslo University Hospital, 3University of Oslo, Oslo, NorwayBackground: Today many people are choosing to have children later in life. Additionally, the use of sophisticated diagnostic tools and screening modalities has increased over recent years. Because of these factors, cancer is being diagnosed more frequently during the child-rearing years. Sociodemographic and cancer-related information on families and minor (0–18 years and young adult (YA (19–25 years children experiencing parental cancer is scarce, but this information is vital for healthcare initiatives aimed toward those potentially adversely affected. Therefore, the aim of this study was to describe features of families and minor and YA children affected by parental cancer in a nationwide population.Methods: Complete Norwegian birth cohort data were obtained from national registries. Descriptive prevalence and incidence statistics were collected for parents and minor and YA children. Logistic regression models were used to assess factors likely to influence parental death.Results: Every year around 0.3% of all families with children under the age of 18 years encounter parental cancer, and 3.1% of minors and 8.4% of YAs have a parent who has been diagnosed with cancer. This study found skin, breast, testicular, and colorectal cancers were the most common forms of cancer diagnosed. The sociodemographic features of those affected were fairly similar to those of the general population. One in five children experienced parental death from cancer; parental death was more often paternal than maternal and was most common in parents diagnosed with leukemia or brain, colorectal, and lung tumors. Deaths are uncommon among parents without cancer.Conclusion: Adequate assistance for minor and YA children affected by parental cancer requires knowledge of their number and characteristics. Parental cancer is more common than

  2. Second primary malignancies in adults with gastric cancer – A US population-based study

    Directory of Open Access Journals (Sweden)

    Binay Kumar Shah

    2016-04-01

    Full Text Available Background: Multiple studies have examined the incidence of secondary primary malignancies (SPM in gastric cancer patients in Europe and Asia. This retrospective review was conducted to analyze risk of SPM in patients with gastric cancer diagnosed in the United States (US.Methods: We included adult patients diagnosed with gastric cancer from the Surveillance, Epidemiology and End Result (SEER 13 database. We calculated the risk of secondary primary malignancies in these patients using the multiple primary standardized incidence ratio (MP-SIR session of SEER*stat software and performed subset analyses of SPM with regard to age, sex, radiotherapy used, and latency period.Results: Among 33,720 patients, 1838 (5.45% developed 2019 secondary primary malignancies with an observed/expected (O/E ratio of 1.11 (95% confidence interval (CI = 1.06-1.16, p<.001 and an absolute excess risk (AER of 18.16 per 10,000 population. The median time to first SPM from the time of diagnosis of gastric cancer was 46.9 months (range 6-239 months. Significant excess risk was observed for gastrointestinal malignancies [O/E ratio 1.71 (CI = 1.59-1.84, p<.001], thyroid [O/E ratio 2.00 (CI = 1.37-2.8, p<.001] and pancreatic cancer [O/E ratio 1.60 (CI = 1.29-21.96, p<.001]. Risk of secondary melanoma, breast cancer and prostate cancer was lower than in the general population.Conclusions: The risk for secondary primary malignancies is significantly increased in adults with gastric cancer compared to the general population.

  3. Design of magnetic septum of CSR

    International Nuclear Information System (INIS)

    In order to satisfy the requirement of beam injection and extraction of CSR, four magnetic septum will be used in the accelerator. In the design, the shape of the lamination is optimized by 2-D magnetic field calculation. Also, in order to decrease the leakage field and obtain a satisfied field distribution, a special auxiliary coil and a shield iron plate are considered and as well as the construction of the septum leg is treated in a special way. As a result, the leakage field is almost zero and the inhomogeneity is less than 0.1% even in the area very near to the septum leg

  4. Design of Bump Magnet of CSR

    Institute of Scientific and Technical Information of China (English)

    2001-01-01

    Four bumpers are required for the injection and extraction of CSR. The parameters of the bumpers are shown in table 1. Because of the steep raising and falling time and therefore the inductance of the magnet should be as small as possible, so the material of the magnet cores must be ferrite. And in order to reduce the cost of the bump magnet, the cross-section of the four ferrite cores was designed as the same, as shown in Fig.1.It is very similar to the lamination of the H-type dipole. And Fig.2 is the...

  5. Regulation of bacterial virulence by Csr (Rsm) systems.

    Science.gov (United States)

    Vakulskas, Christopher A; Potts, Anastasia H; Babitzke, Paul; Ahmer, Brian M M; Romeo, Tony

    2015-06-01

    Most bacterial pathogens have the remarkable ability to flourish in the external environment and in specialized host niches. This ability requires their metabolism, physiology, and virulence factors to be responsive to changes in their surroundings. It is no surprise that the underlying genetic circuitry that supports this adaptability is multilayered and exceedingly complex. Studies over the past 2 decades have established that the CsrA/RsmA proteins, global regulators of posttranscriptional gene expression, play important roles in the expression of virulence factors of numerous proteobacterial pathogens. To accomplish these tasks, CsrA binds to the 5' untranslated and/or early coding regions of mRNAs and alters translation, mRNA turnover, and/or transcript elongation. CsrA activity is regulated by noncoding small RNAs (sRNAs) that contain multiple CsrA binding sites, which permit them to sequester multiple CsrA homodimers away from mRNA targets. Environmental cues sensed by two-component signal transduction systems and other regulatory factors govern the expression of the CsrA-binding sRNAs and, ultimately, the effects of CsrA on secretion systems, surface molecules and biofilm formation, quorum sensing, motility, pigmentation, siderophore production, and phagocytic avoidance. This review presents the workings of the Csr system, the paradigm shift that it generated for understanding posttranscriptional regulation, and its roles in virulence networks of animal and plant pathogens.

  6. Measurements of indoor radon concentration with CSR detectors

    International Nuclear Information System (INIS)

    The measurements of indoor radon concentration in representative dwellings in Shenyang City were made by CSR detectors, and the results were compared with those obtained by the grab sampling technique. It was shown that the results of the latter were 15%-50% less, and CSR detectors were more suitable for the environment radon investigation

  7. A draft of a business model based on CSR

    OpenAIRE

    Flak, Olaf; Pyszka, Adrian

    2011-01-01

    CSR is a new trend in doing business. Therefore the main goal of this article was to prove that social entrepreneurship and activities in Corporate Social Responsibility provide a new way for creating innovative strategies inside and outside organization (close and open innovations). This is a new innovative CSR-driven business model going beyond traditional management and economic thinking.

  8. Consumer perceptions of CSR: (how) is China different?

    NARCIS (Netherlands)

    A. Kolk; W. van Dolen; L. Ma

    2015-01-01

    Purpose Most studies on consumers and corporate social responsibility (CSR) have focused on Western contexts. Consequently, good insight is lacking into non-Western markets where consumers may respond differently. China is a case in point, despite the popularity of the CSR concept and high societal

  9. Determinants of voluntary CSR disclosure: Empirical evidence from Germany

    NARCIS (Netherlands)

    R. Gamerschlag (Ramin); K. Möller (Klaus); F.H.M. Verbeeten (Frank)

    2011-01-01

    textabstractCurrently, companies spend a great deal of effort on Corporate Social Responsibility (CSR) disclosures. CSR disclosure relates to the provision of information on companies' environmental and social performance. From an economic perspective, companies might disclose this information to av

  10. Individual firm and market dynamics of CSR activities

    NARCIS (Netherlands)

    Wirl, F.; Feichtinger, G.; Kort, P.M.

    2013-01-01

    This paper investigates how firms should plan corporate social responsibility (short CSR). This dynamic analysis starts with a firm's intertemporal optimization problem, and proceeds to analyze interactions with other firms, which are crucial: if CSR is profitable for firm A then it is most likely a

  11. THE GENDER DIFFERENCES EFFECTS ON CORPORATE SOCIAL RESPONSIBILITY (CSR

    Directory of Open Access Journals (Sweden)

    LILIANA NICOLETA SIMIONESCU

    2015-07-01

    Full Text Available Corporate Social Responsibility (CSR refers to company's activities through which they need to contribute to the society well-being. Companies which are socially responsible operate their business in such way stakeholders requirements are a meet as well as ethical, legal, economical and philanthropic expectations toward the society where companies operates. Moreover, businesses decisions and strategies should take into consideration and should act with more responsibility to shareholders, customers, employees, and suppliers. Company's responsibility is more than just legal and economic responsibility. Companies including CSR into their business strategies increase their competitiveness alongside other benefits. Regardless of the heated debates which have been taking place between academics, researchers, scholars, and corporate executives, CSR concept remains open to a range of definitions As well as understanding. This paper aim is to theoretically investigate how differences in gender effect on corporate social responsibility activities with impact on companies’ performance in developing countries. In order to achieve the paper aim, following the literature on CSR and research background, comprehensive research framework was developed. Despite the fact that CSR have been debated on many topics, the gender differences effects on CSR in developing countries is scarce. To fill in this gap, this paper developed a conceptual research framework that enhance the literature on CSR as regard the differences linking male and female’s orientation toward CSR activities.

  12. Consumers’ responses to CSR in a cross-cultural setting

    Directory of Open Access Journals (Sweden)

    Hakan Karaosman

    2015-12-01

    Full Text Available The paper aims to clarify the relationship between corporate social responsibility (CSR and consumer behaviour in an international setting. Consumers’ responses to CSR activities and the impact on the purchase decision are limited discourses. CSR-based studies in the fashion and apparel industry are also scarce. Therefore, this study attempts to enlighten the subject of how consumers from different countries respond to CSR adopted in the fashion and apparel industry. This study is based on an exploratory qualitative research for which focus group interviews, including six group discussions with Spanish and Turkish consumers, have been used. The fundamental dimension for sampling was consumers’ interest and knowledge of CSR-related issues. The data were examined by constant comparison analysis. The paper provides empirical insights that suggest that these consumers, regardless of their country of origin, perceive CSR actions as part of companies’ marketing strategies, while overall consumer awareness to CSR is low. Moreover, the criteria, which determine the purchase decision is to be governed by self-interest. A difference between participants from both countries has been found with regard to their demand for more regulation towards CSR. An identified research need in international marketing discipline, is fulfilled in this study.

  13. Regulation of bacterial virulence by Csr (Rsm) systems.

    Science.gov (United States)

    Vakulskas, Christopher A; Potts, Anastasia H; Babitzke, Paul; Ahmer, Brian M M; Romeo, Tony

    2015-06-01

    Most bacterial pathogens have the remarkable ability to flourish in the external environment and in specialized host niches. This ability requires their metabolism, physiology, and virulence factors to be responsive to changes in their surroundings. It is no surprise that the underlying genetic circuitry that supports this adaptability is multilayered and exceedingly complex. Studies over the past 2 decades have established that the CsrA/RsmA proteins, global regulators of posttranscriptional gene expression, play important roles in the expression of virulence factors of numerous proteobacterial pathogens. To accomplish these tasks, CsrA binds to the 5' untranslated and/or early coding regions of mRNAs and alters translation, mRNA turnover, and/or transcript elongation. CsrA activity is regulated by noncoding small RNAs (sRNAs) that contain multiple CsrA binding sites, which permit them to sequester multiple CsrA homodimers away from mRNA targets. Environmental cues sensed by two-component signal transduction systems and other regulatory factors govern the expression of the CsrA-binding sRNAs and, ultimately, the effects of CsrA on secretion systems, surface molecules and biofilm formation, quorum sensing, motility, pigmentation, siderophore production, and phagocytic avoidance. This review presents the workings of the Csr system, the paradigm shift that it generated for understanding posttranscriptional regulation, and its roles in virulence networks of animal and plant pathogens. PMID:25833324

  14. 5 CFR 847.503 - Transfers from the CSR Fund.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Transfers from the CSR Fund. 847.503 Section 847.503 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE... from the CSR Fund. For elections of NAFI retirement system coverage under § 847.441, the amount...

  15. 5 CFR 847.502 - Transfers to the CSR Fund.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Transfers to the CSR Fund. 847.502 Section 847.502 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE... to the CSR Fund. For elections of CSRS or FERS coverage under § 847.411 or FERS coverage and...

  16. Assessment of depression and anxiety in adult cancer outpatients: a cross-sectional study

    Directory of Open Access Journals (Sweden)

    Shahzad Mohammad A

    2010-10-01

    Full Text Available Abstract Background The prevalence of anxiety and depressive disorders in cancer patients and its associated factors in Pakistan is not known. There is a need to develop an evidence base to help introduce interventions as untreated depression and anxiety can lead to significant morbidity. We assessed the prevalence of depression and anxiety among adult outpatients with and without cancer as well as the effect of various demographic, clinical and behavioral factors on levels of depression and anxiety in cancer patients. Methods This cross-sectional study was carried out in outpatient departments of Multan Institute of Nuclear Medicine and Radiotherapy and Nishtar Medical College Hospital, Multan. Aga Khan University Anxiety and Depression Scale (AKUADS was used to define the presence of depression and anxiety in study participants. The sample consisted of 150 diagnosed cancer patients and 268 participants without cancer (control group. Results The mean age of cancer patients was 40.85 years (SD = 16.46 and median illness duration was 5.5 months, while the mean age of the control group was 39.58 years (SD = 11.74. Overall, 66.0% of the cancer patients were found to have depression and anxiety using a cutoff score of 20 on AKUADS. Among the control group, 109 subjects (40.7% had depression and anxiety. Cancer patients were significantly more likely to suffer from distress compared to the control group (OR = 2.83, 95% CI = 1.89-4.25, P = 0.0001. Performing logistic regression analysis showed that age up to 40 years significantly influenced the prevalence of depression and anxiety in cancer patients. There was no statistically significant difference between gender, marital status, locality, education, income, occupation, physical activity, smoking, cancer site, illness duration and mode of treatment, surgery related to cancer and presence of depression and anxiety. Cancers highly associated with depression and anxiety were gastrointestinal

  17. Assessment of depression and anxiety in adult cancer outpatients: a cross-sectional study

    International Nuclear Information System (INIS)

    The prevalence of anxiety and depressive disorders in cancer patients and its associated factors in Pakistan is not known. There is a need to develop an evidence base to help introduce interventions as untreated depression and anxiety can lead to significant morbidity. We assessed the prevalence of depression and anxiety among adult outpatients with and without cancer as well as the effect of various demographic, clinical and behavioral factors on levels of depression and anxiety in cancer patients. This cross-sectional study was carried out in outpatient departments of Multan Institute of Nuclear Medicine and Radiotherapy and Nishtar Medical College Hospital, Multan. Aga Khan University Anxiety and Depression Scale (AKUADS) was used to define the presence of depression and anxiety in study participants. The sample consisted of 150 diagnosed cancer patients and 268 participants without cancer (control group). The mean age of cancer patients was 40.85 years (SD = 16.46) and median illness duration was 5.5 months, while the mean age of the control group was 39.58 years (SD = 11.74). Overall, 66.0% of the cancer patients were found to have depression and anxiety using a cutoff score of 20 on AKUADS. Among the control group, 109 subjects (40.7%) had depression and anxiety. Cancer patients were significantly more likely to suffer from distress compared to the control group (OR = 2.83, 95% CI = 1.89-4.25, P = 0.0001). Performing logistic regression analysis showed that age up to 40 years significantly influenced the prevalence of depression and anxiety in cancer patients. There was no statistically significant difference between gender, marital status, locality, education, income, occupation, physical activity, smoking, cancer site, illness duration and mode of treatment, surgery related to cancer and presence of depression and anxiety. Cancers highly associated with depression and anxiety were gastrointestinal malignancies, chest tumors and breast cancer. This study

  18. Analysis of National and EU Policies Supporting CSR and Impact

    DEFF Research Database (Denmark)

    Moon, Jeremy; Slager, Rieneke; Anastasiadis, Stephanos;

    The purpose of this report is to provide an overview of the place of governmental policies in encouraging and supporting Corporate Social Responsibility (CSR) and their effectiveness therein. By: Moon, Jeremy - Slager, Rieneke - Brunn, Christoph - Hardi, Peter - Steen Knudsen, Jette - 2012 The very...... thought of a relationship between CSR and government policies would, from some perspectives, seem counter-intuitive or simply wrong. From these perspectives it would appear to be a category error that a concept founded on voluntarism, vs CSR, should be shaped by the antithesis of voluntarism, vs public...... policy. What the report finds however is that in general terms there has been a remarkable growth of public policies for CSR in Europe. This finding is confirmed both by review of the relevant literature but also our own pan-European analysis. No longer is CSR mainly implicit in public policies...

  19. A Nordic Perspective of Corporate Social Responsibility (CSR

    Directory of Open Access Journals (Sweden)

    Siri Granum Carson

    2011-05-01

    Full Text Available This introduction points to the divergent factors relevant to the topic of CSR, clearly indicating the need for multidisciplinary and cross-disciplinary approaches to this research area. This is reflected in the way CSR has developed at NTNU. For the past 10 years, there has been a focus on CSR in different ways; in course curricula, research projects, and strategic activities across faculties and department and as the focus area within two of the six overall research strategic areas at NTNU: the Globalization research program and the Maritime research program. Environment and energy are core topics in the programs, hereunder long traditions of collaboration with industry in innovative research projects are found. The science and technology profile, but with close connections with the social sciences and humanities, distinguishes CSR research at NTNU. The research focus on CSR attracts students and support possibilities for increased collaboration with industry.

  20. Future atomic physics researches at HIRFL-CSR

    International Nuclear Information System (INIS)

    A new storage ring system, HIRFL-CSR, is now in construction in the National Laboratory of Heavy Ion Research Facility of Lanzhou, China. The new facility consists of a main ring (CSRm) and an experimental ring (CSRe). With the flexibility of the production and the investigation of highly charged ions and radioactive ion beams the new HIRFL-CSR facility will make many frontier atomic physics researches possible in near future. The future physics researches at the HIRFL-CSR are now under consideration. In this paper an overview of the HIRFL-CSR project is given, and the main atomic physics programs to be carried at the HIRFL-CSR are presented. (orig.)

  1. CSR BENEFITS AND COSTS IN A STRATEGIC APPROACH

    Directory of Open Access Journals (Sweden)

    Diana Corina Gligor – Cimpoieru

    2015-09-01

    Full Text Available In recent decades corporate social responsibility (CSR has captured the interest of both practitioners and academics, being a concept extensively analyzed and discussed in terms of its many facets. But maybe due its complexity, still lacking a unified approach and a widely accepted definition, CSR is still often seen as having a peripheral role, auxiliary for a business organization, without even understanding its essence and having overlooked its extraordinary potential to determine multiple bivalent benefits for companies and local communities. Even if CSR benefits are identified, the analysis is often limited to an optimistic view, lacking a realistic approach that recognizes and takes into account also the costs and risks associated. With this paper we aim at identifying the most significant CSR benefits and costs in an attempt to offer a realistic pledging for the importance of CSR implementation in a strategic approach.

  2. CSR BALANCED SCORECARD SYSTEMS AND BUSINESS PERFORMANCES: SMEs CASE STUDY

    Directory of Open Access Journals (Sweden)

    Edward Sek Khin Wong

    2016-01-01

    Full Text Available This paper aims to examine the performance measurement using the CSR Balanced Scorecard system in SMEs firms in Malaysia. It investigates the relationships of the four perspectives of CSR Balanced Scorecard system toward performance measurement. The purpose of this paper is to in- vestigate whether or not the improvement of the non-financial CSR measures will lead to the im- provement of performance measures. To test these relationships, data were collected using the four perspectives approach introduced by Utting (2007. The finding indicates that the organizational business performance can be greatly increased by putting greater emphasis to CSR measures. The results also reveal that the increases of firms customer’s satisfaction is caused by the increase imple- mentation of CSR measurement. At the end of the article, the implications of this study for SME industries and some suggestions are discussed for future studies.

  3. Routine radiography does not have a role in the diagnostic evaluation of ambulatory adult febrile neutropenic cancer patients

    NARCIS (Netherlands)

    Nijhuis, CSMO; Gietema, JA; Vellenga, E; Daenen, SMGJ; De Bont, ESJM; Kamps, WA; Groen, HJM; van der Jagt, EJ; van der Graaf, WTA

    2003-01-01

    Cancer patients treated with chemotherapy are susceptible to bacterial infections. When an adult patient presents with febrile neutropenia. standard diagnostic care includes physical examination, laboratory diagnostics, chest X-ray (CXR) and sinus radiography. However, the yield of routine radiograp

  4. The electron target for the CSR

    International Nuclear Information System (INIS)

    An ultralow energy photoelectron cooler for the novel cryogenic electrostatic storage ring CSR is under development. The electron device will serve as a major tool for electron-ion collision studies and for phase space cooling of 20-300 keV (E/Q, charge number Q) ions in velocity matched electron and ion beams. Electrons in energy range from 165 eV (matched to 20 keV protons) down to a fraction of eV (matched to heavy molecules of mass up to 160 A/Q) will be confined by 30-150 Gauss guiding magnetic field in a newly developed configuration. The key points related to ultralow energy cooling operation (maximal gun current at the low energies, minimal longitudinal temperature) have been taken into account and were recently studied by experiments at the TSR e-target. Adiabatic beam transport has been simulated by the TOSCA code. In this talk we present experimental and simulation results as well as the mechanical and cryogenic concept of the CSR electron target

  5. Cancer Prevention Among Adults Aged 45–64 Years: Setting the Stage

    OpenAIRE

    Marcia G. Ory; Anderson, Lynda A.; Friedman, Daniela B.; Pulczinski, Jairus C.; Eugene, Nola; Satariano, William A

    2014-01-01

    As part of setting the stage for this supplement to the American Journal of Preventive Medicine, a life-course perspective is presented to assist in understanding the importance of cancer prevention for adults in midlife, a period roughly spanning 20 years between ages 45 and 64 years. Drawing on disciplinary perspectives from the social sciences and public health, several life-course themes are delineated in this article: how specific life transitions present unique opportunities for interve...

  6. Strategies to promote regular exercise in adolescent and young adult cancer survivors

    OpenAIRE

    Barnes MJ; Casazza K; Austin H

    2015-01-01

    Margaux J Barnes, Krista Casazza, Heather Austin Department of Pediatrics, Division of General Pediatrics and Adolescent Medicine, University of Alabama at Birmingham (UAB), Birmingham, AL, USA Abstract: Adolescents and young adults (AYAs) diagnosed with cancer are at increased risk for current and future health problems and premature death. Given the known risks for increased mortality and morbidity, fostering the development of exercise behaviors that may target the specific late effects e...

  7. Radiation-induced thyroid cancer in children and adult population, living in contaminated territories after the Chernobyl accident

    International Nuclear Information System (INIS)

    Results of the analysis of own and literature data on the occurrence and development of radiation-induced thyroid cancer are presented. Analysis involved distribution of the thyroid cancer incidence among 1 million children and 3 millions adults, living in the radioactively contaminated territories of Russia by age and sex. The main attention was paid to the understanding of latency period of spontaneous and radiation-induced cancer, comparison of oncological pathology features in children and adults, and the role of screening in the increase of incidence rate parameters. Analysis permitted to offer new interpretation of several previously known facts and to make new statements on the induction and development of radiogenic thyroid cancer, in particularly, on far more significant increase of the thyroid cancer incidence in adults, living in the contaminated territories, than it was considered earlier

  8. CSR-1 and P granules suppress sperm-specific transcription in the C. elegans germline.

    Science.gov (United States)

    Campbell, Anne C; Updike, Dustin L

    2015-05-15

    Germ granules (P granules) in C. elegans are required for fertility and function to maintain germ cell identity and pluripotency. Sterility in the absence of P granules is often accompanied by the misexpression of soma-specific proteins and the initiation of somatic differentiation in germ cells. To investigate whether this is caused by the accumulation of somatic transcripts, we performed mRNA-seq on dissected germlines with and without P granules. Strikingly, we found that somatic transcripts do not increase in the young adult germline when P granules are impaired. Instead, we found that impairing P granules causes sperm-specific mRNAs to become highly overexpressed. This includes the accumulation of major sperm protein (MSP) transcripts in germ cells, a phenotype that is suppressed by feminization of the germline. A core component of P granules, the endo-siRNA-binding Argonaute protein CSR-1, has recently been ascribed with the ability to license transcripts for germline expression. However, impairing CSR-1 has very little effect on the accumulation of its mRNA targets. Instead, we found that CSR-1 functions with P granules to prevent MSP and sperm-specific mRNAs from being transcribed in the hermaphrodite germline. These findings suggest that P granules protect germline integrity through two different mechanisms, by (1) preventing the inappropriate expression of somatic proteins at the level of translational regulation, and by (2) functioning with CSR-1 to limit the domain of sperm-specific expression at the level of transcription. PMID:25968310

  9. Double Jeopardy? Age, Race, and HRQOL in Older Adults with Cancer

    Directory of Open Access Journals (Sweden)

    Keith M. Bellizzi

    2012-01-01

    Full Text Available Understanding the post-treatment physical and mental function of older adults from ethnic/racial minority backgrounds with cancer is a critical step to determine the services required to serve this growing population. The double jeopardy hypothesis suggests being a minority and old could have compounding effects on health. This population-based study examined the physical and mental function of older adults by age (mean age = 75.7, SD = 6.1, ethnicity/race, and cancer (breast, prostate, colorectal, and gynecologic as well as interaction effects between age, ethnicity/race and HRQOL. There was evidence of a significant age by ethnicity/race interaction in physical function for breast, prostate and all sites combined, but the interaction became non-significant (for breast and all sites combined when comorbidity was entered into the model. The interaction persisted in the prostate cancer group after controlling for comorbidity, such that African Americans and Asian Americans in the 75–79 age group report lower physical health than non-Hispanic Whites and Hispanic Whites in this age group. The presence of double jeopardy in the breast and all sites combined group can be explained by a differential comorbid burden among the older (75–79 minority group, but the interaction found in prostate cancer survivors does not reflect this differential comorbid burden.

  10. In a unique position or squeezed out? The professional roles of general practitioners in cancer care in general and of young adult cancer patients in particular

    DEFF Research Database (Denmark)

    Hølge-Hazelton, B.; Christensen, I.

    2009-01-01

    BACKGROUND: Exploring experiences of general practitioners (GPs), regarding roles in cancer care of young adults (YAs). METHODS: Ten qualitative interviews with GPs were theoretically analyzed against professional characteristics. FINDINGS: The GPs tended to make general statements, using everyday...... language, they experience that their patients disappear, they are seldom involved, and they lack knowledge. CONCLUSIONS: GPs have few experiences with YA cancer patients, but they have a potentially unique role in general primary cancer care if they develop their vocational vocabulary, relate more to...

  11. Defining, Measuring and Supporting Success: Meeting the Challenges of Comprehensive School Reform Research. CSR Connection.

    Science.gov (United States)

    Appelbaum, Deborah; Schwartzbeck, Terri Duggan

    Many educators believe that comprehensive school reform (CSR) holds real promise for improving schools, as many CSR programs are based in research and have documented success. However, in the past year, there has been increased emphasis on CSR programs' evidence of effectiveness and scrutiny of CSR evaluations' degree of rigor. Questions exist…

  12. Corporate Social Responsibility (CSR) and energy industry; Cororate Social Responsibility (CSR) und Energiewirtschaft

    Energy Technology Data Exchange (ETDEWEB)

    Landhaeusser, Werner (ed.) [Mader GmbH und Co. KG, Leinfelden-Echterdingen (Germany); Hildebrandt, Alexandra

    2016-05-01

    What means Corporate Social Responsibility (CSR) in the energy industry? A rising energy demand with limited natural resources pose utilities, industry and consumers with new challenges. This book follows an interdisciplinary approach and for the first time brings together debates and findings from industry, science, politics, culture and media. Because the energy transition can only succeed if it is comprehensible for the individual and fragmented perspectives and interests are merged. [German] Was bedeutet CSR in der Energiewirtschaft? Ein steigender Energiebedarf bei begrenzten natuerlichen Ressourcen stellt Energieversorger, Industrie und Verbraucher vor immer neue Herausforderungen. Dieses Buch folgt einem interdisziplinaeren Ansatz und fuehrt erstmals Debatten und Erkenntnisse aus Wirtschaft, Wissenschaft, Politik, Kultur und Medien zusammen. Denn die Energiewende kann nur gelingen, wenn sie fuer den Einzelnen fassbar wird und fragmentierte Sichtweisen und Interessenlagen zusammengefuehrt werden.

  13. Establishment of CSR Matter-Element Evaluation Model in Perspective of Low Carbon Economy in China

    OpenAIRE

    Li Furong; Zhang Gang

    2013-01-01

    With the development of CSR concept, more and more enterprises begin to bring CSR into practice. Especially in the era of low-carbon economy develops quickly, CSR practice is going to mature. In order to make a scientific evaluation on CSR and promote the comprehensive development of CSR, this study develop a new CSR evaluation model under requires of low-carbon economy development. This CSR evaluation model combined G1 weighting method with the Matter-Element Model and finally verified by an...

  14. Mechanisms in Psychosocial Interventions for Adults Living with Cancer: Opportunity for Integration of Theory, Research, and Practice

    Science.gov (United States)

    Stanton, Annette L.; Luecken, Linda J.; MacKinnon, David P.; Thompson, Elizabeth H.

    2013-01-01

    Objective: The diagnosis and treatment of cancer are highly stressful experiences that can profoundly affect emotional and physical well-being. Hundreds of longitudinal investigations that identify risk and protective factors for psychological and physical adjustment in adults living with cancer and numerous randomized controlled psychosocial…

  15. CSR and CSR Reporting: Reporting as a way to create Socially Responsible Business

    Directory of Open Access Journals (Sweden)

    Fabio Andrés Bonilla Sanabria

    2011-12-01

    In this scenario the Reporting of Non-Financial Information is studied as a way to create socially responsible businesses. In addressing the reporting of non-financial information, the article provides a state of affairs regarding reporting and considers specific examples of disclosure of corporate information. The CSR battle has been transferred to the reporting of non-financial information but in this field there are many difficulties unresolved and challenges ahead.

  16. Older adults' attitudes about continuing cancer screening later in life: a pilot study interviewing residents of two continuing care communities

    Directory of Open Access Journals (Sweden)

    Walter Louise C

    2006-08-01

    Full Text Available Abstract Background Individualized decision making has been recommended for cancer screening decisions in older adults. Because older adults' preferences are central to individualized decisions, we assessed older adults' perspectives about continuing cancer screening later in life. Methods Face to face interviews with 116 residents age 70 or over from two long-term care retirement communities. Interview content included questions about whether participants had discussed cancer screening with their physicians since turning age 70, their attitudes about information important for individualized decisions, and their attitudes about continuing cancer screening later in life. Results Forty-nine percent of participants reported that they had an opportunity to discuss cancer screening with their physician since turning age 70; 89% would have preferred to have had these discussions. Sixty-two percent believed their own life expectancy was not important for decision making, and 48% preferred not to discuss life expectancy. Attitudes about continuing cancer screening were favorable. Most participants reported that they would continue screening throughout their lives and 43% would consider getting screened even if their doctors recommended against it. Only 13% thought that they would not live long enough to benefit from cancer screening tests. Factors important to consider stopping include: age, deteriorating or poor health, concerns about the effectiveness of the tests, and doctors recommendations. Conclusion This select group of older adults held positive attitudes about continuing cancer screening later in life, and many may have had unrealistic expectations. Individualized decision making could help clarify how life expectancy affects the potential survival benefits of cancer screening. Future research is needed to determine whether educating older adults about the importance of longevity in screening decisions would be acceptable, affect older adults

  17. Materiality Analysis for CSR Reporting in Spanish SMEs

    Directory of Open Access Journals (Sweden)

    Elena Escrig-Olmedo

    2012-01-01

    Full Text Available Most corporate social responsibility (CSR standards have not been designedto be implemented in small and medium sized enterprises (SMEs. Giventhat 99% of Spanish companies are SMEs, this study aims to propose aselection of basic CSR material issues that, because of their usefulness andsignificance, should be adapted to Spanish SMEs and their stakeholders.This study provides a CSR model for SMEs that includes the most importantsocial, environmental, and corporate governance issues. This model, whichis based on expert knowledge, is useful for integrating sustainability in themanagement of SMEs and enhancing the management of stakeholders.

  18. The differentiated effects of CSR actions in the service industry

    OpenAIRE

    Casado-Díaz, Ana B.; Nicolau, Juan Luis; Ruiz Moreno, Manuel Felipe; Sellers Rubio, Ricardo

    2014-01-01

    Purpose – The purpose of this study is to attempt to explain why the impact of Corporate Social Responsibility (CSR) initiatives may be different and/or more important in service firms compared to manufacturing firms. CSR is becoming a common strategy, hence its extensive research. Central to it is the analysis of the effect of CSR on a firm’s performance, whose outcome depends on firm-specific and industry-related factors. Design/methodology/approach – The event study methodology is applied ...

  19. Hypernucleus Production at RHIC and HIRFL-CSR Energy

    International Nuclear Information System (INIS)

    We calculated the hypertriton production at RHIC-STAR and HIRFL-CSR acceptance, with a multi-phase transport model (AMPT) and a relativistic transport model (ART), respectively. In specific, we calculated the Strangeness Population Factor S3 = Λ3H/(3He x Λ/p) at different beam energy. Our results from AGS to RHIC energy indicated that the collision system may change from hadronic phase at AGS energies to partonic phase at RHIC energies. Our calculation at HIRFL-CSR energy supports the proposal to measure hypertriton at HIRFL-CSR.

  20. Design of Database System of HIRFL-CSR Beam Line

    International Nuclear Information System (INIS)

    This paper introduces the database design and optimization for the power supply system of Lanzhou Heavy Ion Accelerator CSR (HIRFL-CSR) beam line. Based on HIFEL-CSR main Oracle database system, the interface was designed to read parameters of the power supply while achieving real-time monitoring. A new database system to store the history data of power supplies was established at the same time, and it realized the data exchange between Oracle database system and Access database system. Meanwhile, the interface was designed conveniently for printing and query parameters. (authors)

  1. From CSR to Social Risk Management

    DEFF Research Database (Denmark)

    Taarup Esbensen, Jacob

    2014-01-01

    engagement management systems that is promoted through the standard. The implemented social risk management systems are ineffective because they makes the MNC unable to recognise the value of weak ties and fail to build legitimacy and trust with some of the key stakeholders resulting in the creation of more......When it comes to social risks multinational companies (MNC) within Mining are one of the most exposed businesses one can imagine. This paper examines how social risk management is practiced through the case of Teghout copper-molybdenum mine in North- Eastern Armenia, supplemented with evidence from...... other mining MNCs in the country, onsite fieldwork, interviews with key stakeholders, and public available information. This evidence suggest that a standards based social risk management strategy is adopted and that this strategy is based on international Corporate Social Responsibility (CSR) standards...

  2. Radioactive ion beam line of CSR

    International Nuclear Information System (INIS)

    A new radioactive ion beam line designed to work at higher energy equivalent up to a magnetic rigidity of 10.64 Tm is going to be constructed at Lanzhou. It is to connect the main ring and the experiment ring of the HIRFL-CSR complex. The separator is mirror-symmetrically configured both in geometry and magnet strength, achieving a point-point and parallel-parallel image at its intermediate focal plane with maximum spatial dispersion. Achromatism is automatically realized at the final focal plane. The total length is about 26 meters. Its resolution power of magnetic rigidity is 1200 at +- 1% momentum deviation and +- 25 mrad divergence simultaneously. With sextupole- and octupole- magnets carefully positioned and powered, second and third-order aberrations are corrected to a large extent. The magnet design has already fulfilled

  3. CSR communication to consumers in clothing markets - Mapping consumer interest, awareness, attitudes and expectations

    OpenAIRE

    Kivekäs, Lotta

    2013-01-01

    CSR communication to consumers in clothing markets - Mapping consumer interest, awareness, attitudes and expectations. Objective of the Study The aim of the study was to investigate consumer perceptions of CSR (corporate social responsibility) and CSR communication in order to improve company ability to effectively communicate on CSR. The study was motivated by research indicating low consumer awareness of and trust in CSR. The study focused on the clothing industry as clothing comp...

  4. CSR Communication - An Employee Perspective : Tailoring Internal Communication using Employee Preferences for Content, Style and Channel.

    OpenAIRE

    Jonsson, Viktoria; Linnér, Rebecka

    2016-01-01

    Corporate Social Responsibility (CSR) represents a theory and practice that is well-known and communicating its content has shown to play an important role in order to exploit its advantages and engage stakeholders on CSR issues. Even though, CSR communication has shown to be a real challenge, since corporations are encouraged to engage in CSR, but not to communicate too loud about this engagement. This study was inspired by Jenny Dawkins (2005) and her initial idea that tailoring CSR message...

  5. Analýza CSR aktivit vybrané společnosti

    OpenAIRE

    Kačabová, Petra

    2013-01-01

    The Master thesis deals with a topic of Corporate Social Responsibility. In the theoretical part the CSR concept is explained. The author describes the increasing significance of CSR, its definition, three main pillars, reasons why to implement CSR and its possible crtiticism. Furthermore, it shows indices used for measurement and organizations handling CSR issue. In the practical part, at first, the influnce of CSR on consumers' decision making process and behaviour is demonstrated. The gene...

  6. How Does It Fit? Exploring the Congruence Between Organizations and Their Corporate Social Responsibility (CSR) Activities

    OpenAIRE

    Jong, de, J.; Meer, Van Der, Alex J.

    2015-01-01

    Several studies have focused on the effects of corporate social responsibility (CSR) fit on external stakeholders’ evaluations of CSR activities, attitudes towards companies or brands, and behaviors. The results so far have been contradictory. A possible reason may be that the concept of CSR fit is more complicated than previously assumed. Researchers suggest that there may be different types of CSR fit, but so far no empirical research has focused on a typology of CSR fit. This study fills t...

  7. Cancer incidence and survival among adolescents and young adults in Korea.

    Directory of Open Access Journals (Sweden)

    Eun-Kyeong Moon

    Full Text Available BACKGROUND: In Korea, cancer is the third leading cause of death among adolescents and young adults (AYAs. However, cancer incidence and survival trends among AYAs (15-29 years have never been studied in Korea. Therefore, this study aimed to investigate the incidence and relative survival rates and their trends among AYAs in Korea. MATERIALS AND METHODS: Cancer incidence data from 1999-2010 were obtained from the Korea Central Cancer Registry (KCCR. Each cancer was classified into subgroups according to the National Cancer Institute Surveillance, Epidemiology, and End Results (SEER AYA site recode. Percent distributions, age-specific incidence rates, age-standardized incidence rates per million, and annual percent changes (APCs were calculated for AYAs according to sex. Five-year relative survival rates were estimated for cases diagnosed between 1993 and 2010 and followed up to 2011. RESULTS: The age-standardized incidence rates of all cancers combined were 196.4 and 367.8 per million for males and females, respectively (male-to-female (M/F ratio: 0.5. The age-standardized incidence rates increased from 208.7 per million in 1999 to 396.4 per million in 2010, and the APC was 6.3% (P<0.001. The five most common cancers among AYAs were thyroid carcinoma, non-Hodgkin lymphoma, stomach carcinoma, breast carcinoma, and acute myeloid leukemia. In males, the 5-year relative survival rate improved, from 46.5% in 1993-1995 to 75.9% in 2006-2010. In females, the 5-year relative survival rate also improved, from 66.7% in 1993-1995 to 89.1% in 2006-2010. CONCLUSIONS: Our study showed increases in cancer incidence and improvements in the 5-year relative survival rate among Korean AYAs. This study also provides additional data regarding temporal and geographic trends in cancer that may enhance future efforts to identify factors affecting cancer incidence and responses to treatment among AYAs.

  8. Evaluation of the Quality of Life in Adult Cancer Survivors (QLACS scale for long-term cancer survivors in a sample of breast cancer survivors

    Directory of Open Access Journals (Sweden)

    Foley Kristie

    2006-12-01

    Full Text Available Abstract Background This paper evaluates psychometric properties of a recently developed measure focusing on the health-related quality of life (HRQL of long-term cancer survivors, the Quality of Life in Adult Survivors scale (QLACS, in a sample of breast cancer survivors. This represents an important area of study, given the large number of breast cancer patients surviving many years post diagnosis. Methods Analyses are based on an 8-year follow-up of a sample of breast cancer survivors who participated in an earlier study conducted in 1995. Participants were re-contacted in 2003 and those who were reachable and agreed to participate (n = 94 were surveyed using a variety of measures including the QLACS. Additional follow-up surveys were conducted 2 weeks and one year later. Psychometric tests of the QLACS included test-retest reliability, concurrent and retrospective validity, and responsiveness. Results The QLACS domain and summary scores showed good test-retest reliability (all test-retest correlations were above .7 and high internal consistency. The Generic Summary Score showed convergent validity with other measures designed to assess generic HRQL. The Cancer-Specific Summary score exhibited divergent validity with generic HRQL measures, but not a cancer-related specific measure. The QLACS Cancer-Specific Summary Score demonstrated satisfactory predictive validity for factors that were previously shown to be correlated with HRQL. The QLACS generally demonstrated a high level of responsiveness to life changes. Conclusion The QLACS may serve as a useful measure for assessing HRQL among long-term breast cancer survivors that are not otherwise captured by generic measures or those specifically designed for newly diagnosed patients.

  9. Nursing care for adolescents and young adults with cancer: literature review.

    Science.gov (United States)

    Dreyer, Juliet; Schwartz-Attias, Irit

    2014-01-01

    Cancer patients belonging to the adolescent and young adult (AYA) age group have unique and very specific needs, which require special attention from the caring staff. The difficulty in maintaining the personal and professional development at this age is both natural and normal. Adding to this, coping with a life-threatening disease turns this stage in life into a period with many dilemmas and challenges of quite a complex nature. AYA patients have to deal with issues above and beyond the disease itself, which create a very complex coping picture. On top of that, prognosis for this age group has not improved in recent years, unlike the situation in other age groups like children and adults. The literature on this subject is extensive and comprehensive. However, most of the papers on this subject are very specific and narrow in their approach, each dealing with a specific topic. In this article, we bring together many different papers which make a wide and comprehensive picture of the subject of AYAs coping with cancer, coupled with recommendations for the caring staff. In this review we focus on the various aspects of the disease and treatments in AYAs, based on the conceptual model of quality of life proposed by Ferrell and colleagues [Cancer Nurs 1992;15:153-160; Cancer Nurs 1992;15:247-253], including physical, social, emotional and spiritual aspects. From the psychological standpoint, most of the papers discuss the negative aspects; however, in this article we try to include some articles from the positive psychology school of thought. From our findings it is apparent that there is an opportunity and need to further explore research in this regard. It is apparent that taking a unique approach to AYA cancer patients is needed in order to deal with the unique needs of this age group. This article aims at putting a framework around this issue, with actionable recommendations for the caring staff.

  10. Reliability and validity of the valued activity inventory for adults with cancer.

    Science.gov (United States)

    Lyons, Kathleen Doyle; Hegel, Mark T; Hull, Jay G; Li, Zhongze; Balan, Stefan; Bartels, Stephen

    2012-01-01

    The authors assessed the psychometric properties of the Valued Activity Inventory for Adults With Cancer (VAI-AC), a self-report instrument that measures activity limitations. Participants included 50 older adults undergoing chemotherapy who completed the VAI-AC and measures of physical and mental function, symptom intensity, and mood 3 days before and the day of chemotherapy. Test-retest reliability was assessed by determining the average number of items for which the importance of an activity was rated consistently and by calculating the intraclass correlation coefficient (ICC) for the first and second VAI-AC scores. Convergent validity was assessed by correlating the VAI-AC scores with the other measures. Participants consistently rated the importance of 90% of the items. The 72-hour test-retest reliability ICC was 0.67. Participants with fewer activity limitations indicated better physical function (r = 0.58, p < .001), better mental function (r = 0.55, p < .001), lower symptom intensity (r = -0.57, p < .001), and fewer depressive symptoms (r = -0.68, p < .001). The VAI-AC demonstrated evidence of test-retest reliability and convergent validity in this convenience sample of older adults undergoing chemotherapy for cancer.

  11. Corporate Social Responsibility (CSR in India: A Review

    Directory of Open Access Journals (Sweden)

    Neelmani Jaysawal

    2015-11-01

    Full Text Available Corporate Social Responsibility (CSR is a concept, which states that Private Corporation or public organization has a responsibility to society. It minimizes the cost as well as risks thereby, increasing the brand value and reputation of the company. According to Bowen, “CSR refers to the obligations of businessmen to pursue those policies to make those decisions or to follow those lines of relations which are desirable in terms of the objectives and values of our society.” The CSR activities need to be in tune with effective strategic policies so that the aim of sustainable environmental, social and economic progress may be achieved. Methodology: This paper is based on qualitative research design consisting of review of literature through secondary sources of data collection. The data has been examined through content analysis process from various books, newspaper articles and journals. This paper seeks to explain various initiatives taken in the field of CSR along with some key challenges.

  12. Lönsamhet med CSR hosMAX Hamburgare

    OpenAIRE

    Nisell, Samuel; Kaya, Roni

    2012-01-01

    När företag engagerar sig i CSR-frågor främjar det miljö och samhälle. Denna rapport utreder hur CSR-arbetet också kan gynna företaget ur ett ekonomiskt perspektiv. Rapporten behandlar hamburgerkedjan Max Hamburgares hållbarhetssatsning och besvarar frågorna: • Är Max Hamburgares CSR-arbete ekonomiskt lönsamt för dem själva? • Är någon/några av Max Hamburgares CSR-åtgärder förlust- respektive vinstaffärer? För att besvara frågorna har en omfattande studie kring ämnet och företaget genomförts ...

  13. THE RELATIONSHIP BETWEEN MODELS OF QUALITY MANAGEMENT AND CSR

    Directory of Open Access Journals (Sweden)

    CĂTĂLINA SITNIKOV

    2015-03-01

    Full Text Available Lately, the quality management has integrated more and more among its components Corporate Social Responsibility (CSR. With strong roots in the foundation for sustainable development, protection of the environment, issues of social justness and economic growth, CSR raises numerous issues related to obtaining profits, business performance and firms and activities based on the quality of management. From the point of view of the last issues, the models of quality management built on the fundamental principles of quality become the foundation and catalyst for the effective implementation of CSR in organizations. This is the reason why it is necessary to investigate the extent to which quality management models provide frameworks and guidelines for integrating CSR in the management of quality and, moreover, in the management of the organization, with a clear focus on the extent to which the concept can be institutionalized and operated by the organization.

  14. Self-consistent simulation of the CSR effect

    International Nuclear Information System (INIS)

    When a microbunch with high charge traverses a curved trajectory, the curvature-induced bunch self-interaction, by way of coherent synchrotron radiation (CSR) and space-charge forces, may cause serious emittance degradation. In this paper, the authors present a self-consistent simulation for the study of the impact of CSR on beam optics. The dynamics of the bunch under the influence of the CSR forces is simulated using macroparticles, where the CSR force in turn depends on the history of bunch dynamics in accordance with causality. The simulation is benchmarked with analytical results obtained for a rigid-line bunch. Here they present the algorithm used in the simulation, along with the simulation results obtained for bending systems in the Jefferson Lab (JLab) free-electron-laser (FEL) lattice

  15. CSR routine for low energy electron beam in GPT

    International Nuclear Information System (INIS)

    General Particle Tracer (GPT) is a particle tracking code, which includes 3D space charge effect based on nonequidistant multigrid Poisson solver or point-to-point method. It is used to investigate beam dynamics in ERL and FEL injectors. We have developed a new routine to simulate coherent synchrotron radiation (CSR) in GPT based on the formalism of Sagan. The routine can calculate 1D-wake functions for arbitrary beam trajectories as well as CSR shielding effect. In particular, the CSR routine does not assume ultrarelativistic electron beam and is therefore applicable at low beam energies in the injector. Energy loss and energy spread caused by CSR effect were checked for a simple circular orbit, and compared with analytic formulas. (author)

  16. CSR jako przedsięwzięcie biznesowe

    OpenAIRE

    Szymon Wierciński

    2011-01-01

    Niniejszy artykuł poświęcony jest relacji między programami społecznej odpowiedzialności biznesu a wynikami finansowymi organizacji (CSR – CFP). Podążając za nurtem badaczy poszukujących biznesowego uzasadnienia dla CSR, autor przedstawia problemy i wyzwania stojące przed menedżerami i naukowcami, dotyczące mierzenia efektywności programów CSR. Przegląd literatury prowadzi do zwrócenia szczególnej uwagi na problem związany z precyzyjnym mierzeniem wpływu CSR na różnych poziomach organizacji i...

  17. CSR, Employee Job Attitude and Behavior: Saudi Bank Experience

    Directory of Open Access Journals (Sweden)

    Mohammad Tahlil AZIM

    2014-11-01

    Full Text Available The present study explores the relation- ship between the external CSR practices of the organizations and employees’ job satisfaction, employee engagement and organizational cit- izenship behavior in the context of the Saudi banking industry. A positive relationship between CSR and employee job satisfaction, employee engagement and organizational citizenship be- havior related to the organization is observed. However, the organizational citizenship behavior related to individual is found unrelated to CSR. The theoretical foundation of the study is ground- ed in the spirit of social identity theory (Tajfel and Turner, 1979 and social exchange theory (Blau, 1964. The study implies that involvement in ex- ternal CSR may be a determinant for maintaining a motivated and enthusiastic workforce. 

  18. Should CSR Be Ignored Due to the Economic Crisis?

    Institute of Scientific and Technical Information of China (English)

    Guo Yan

    2009-01-01

    @@ Due to the economic crisis,many companies are struggling for a living.So,should the Corporate Social Responsibilitv(CSR)be put aside before these companies can secure their survival?Of course the answer is no.

  19. CSR-induced emittance growth in achromats: Linear formalism revisited

    Energy Technology Data Exchange (ETDEWEB)

    Venturini, M.

    2015-09-11

    We review the R-matrix formalism used to describe Coherent Synchrotron Radiation (CSR)-induced projected emittance growth in electron beam transport lines and establish the connection with a description in terms of the dispersion-invariant function.

  20. CSR and the Mediated Emergence of Strategic Ambiguity

    DEFF Research Database (Denmark)

    Guthey, Eric; Morsing, Mette

    2014-01-01

    We develop a framework for understanding how lack of clarity in business press coverage of corporate social responsibility functions as a mediated and emergent form of strategic ambiguity. Many stakeholders expect CSR to exhibit clarity, consistency, and discursive closure. But stakeholders also...... expect CSR to conform to varying degrees of both formal and substantive rationality. These diverse expectations conflict with each other and change over time. A content analysis of press coverage in Denmark suggests that the business media reflect and amplify the ambiguity generated by these shifting...... demands. We propose that this very public lack of discursive closure provides strategic advantages to CSR stakeholders by rendering the concept of CSR adaptable, resilient, and meaningful to diverse interests. From this perspective, strategic ambiguity emerges from a relational and mediated process...

  1. CSR-induced emittance growth in achromats: Linear formalism revisited

    Science.gov (United States)

    Venturini, M.

    2015-09-01

    We review the R-matrix formalism used to describe Coherent Synchrotron Radiation (CSR)-induced projected emittance growth in electron beam transport lines and establish the connection with a description in terms of the dispersion-invariant function.

  2. Does CSR Create Value for Companies In Malaysia? An Empirical Study of Effect of CSR towards Financial Performance on Shariah and Non Shariah-Compliant Companies in Malaysia

    OpenAIRE

    Ding, Huey Chyi

    2015-01-01

    Over the years, there has been a significant rise in the awareness and practice of Corporate Social Responsibility (CSR) globally. Studies covered various dimensions of CSR have been carried out extensively in developed countries, with results varied that CSR active companies outperformed their peers in term of financial returns, others shown no significant correlations while some concluded that CSR activities do not pay. Similar trend of research gained distinctive attention from the develop...

  3. Neighborhood and Family Environment of Expectans Mothers May Influence Prenatal Programming of Adult Cancer Risk: Discussion and an Illustrative DNA Methylation Example

    Science.gov (United States)

    Childhood stressors including physical abuse predict adult cancer risk. Prior research portrays this finding as an indirect mechanism that operates through coping behaviors, including adult smoking, or through increased toxic exposures during childhood. Little is known about pote...

  4. Strategies to improve adherence to treatment in adolescents and young adults with cancer: a systematic review

    Directory of Open Access Journals (Sweden)

    Robertson EG

    2015-07-01

    Full Text Available Eden G Robertson,1,2 Claire E Wakefield,1,2 Kate H Marshall,2 Ursula M Sansom-Daly1–3 1Discipline of Paediatrics, School of Women's and Children's Health, UNSW Medicine, University of New South Wales, University of New South Wales, Kensington, NSW, Australia; 2Behavioural Sciences Unit, Kids Cancer Centre, Sydney Children's Hospital, 3Sydney Youth Cancer Service, Prince of Wales/Sydney Children's Hospital, Randwick, NSW, Australia Purpose: Adolescents and young adults (AYAs with cancer have higher rates of nonadherence to treatment relative to younger and older cancer patients. Efforts to improve adherence in this population are therefore increasing. This review aimed: 1 to synthesize recommendations and strategies used to improve treatment adherence in AYAs with cancer, and 2 to summarize the available evidence supporting the efficacy of adherence-promoting strategies for AYAs with cancer.Methods: We conducted a systematic review with two stages: 1 a narrative stage, to analyze expert recommendations, and 2 an evaluative stage, to summarize quantitative evidence for interventions. Four electronic databases were searched for studies involving AYAs, aged 10–39 years, with cancer, published from 2005 to 2015. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA guidelines were used to ensure quality of the review. The Delphi list was used to assess study quality.Results: Nine articles were identified in the narrative stage of the review. For the evaluative stage, out of 113 screened abstracts, only one eligible intervention was identified. Common themes of adherence-promoting strategies were grouped into five domains: developmental, communication, educational, psychological well-being, and logistical/management strategies. Strategies to address developmental stage and to improve communication were the most highly recommended to improve adherence. Few strategies focused on the role of the patient in adherence. One

  5. Creating shared value through strategic CSR in tourism

    OpenAIRE

    Camilleri, Mark Anthony

    2012-01-01

    Literature review about corporate social responsibility (CSR) suggests that there are organisational benefits to be gained from unintentional discretionary expenditure in laudable behaviour. With this in mind, the methodology integrates insights from the ‘stakeholder theory’ and the ‘resource-based view theory of the firm’ to sharpen the strategic base for CSR investment. Quantitative and qualitative research techniques have been used to discover how business organisations a...

  6. THE RELATIONSHIP BETWEEN MODELS OF QUALITY MANAGEMENT AND CSR

    OpenAIRE

    CĂTĂLINA SITNIKOV; CLAUDIU BOCEAN

    2015-01-01

    Lately, the quality management has integrated more and more among its components Corporate Social Responsibility (CSR). With strong roots in the foundation for sustainable development, protection of the environment, issues of social justness and economic growth, CSR raises numerous issues related to obtaining profits, business performance and firms and activities based on the quality of management. From the point of view of the last issues, the models of quality management built o...

  7. Communicating CSR: practices among Switzerland's top 300 companies

    OpenAIRE

    Birth, Gregory; Illia, Laura; Lurati, Fransceso; Zamparini, Alessandra

    2011-01-01

    Purpose – The purpose of this paper is to provide a picture of the practice of corporate social responsibility (CSR) communication among the top 300 companies in Switzerland and to investigate how favorable the cultural context is for this kind of communication. Design/methodology/approach – The investigation of the top 300 companies in Switzerland was conducted using a written survey that built on previous studies. Findings – CSR communication in Switzerland appears to be well developed, b...

  8. Communicating CSR and Brand Personality through Social Media

    OpenAIRE

    Lopez, Cecilia Maria

    2015-01-01

    In the competitive atmosphere of today's business world, corporate social responsibility (CSR) has become yet another factor organizations use to distinguish themselves and make their values apparent to their audiences. Social media have helped organizations communicate these characteristics with their audiences by enabling timely and cost-effective communication between individuals and organizations. While many studies have explored the role of social media in communicating CSR messages, few...

  9. Application of CSR Programs in the Airline Industry

    OpenAIRE

    Anttila, Timo; Kretzschmar, Annika

    2010-01-01

    The subject of this thesis was to analyze the global airline business environment and corporate social responsibility (CSR) program implementations of some well-known airlines. The research has been conducted with the assumption that corporate social responsibility theory is valid. Our purpose was to give the reader and overall impression of airline industry in general, CSR theory and its most important elements. The work is divided into two distinct parts; theory and practical analysis o...

  10. Impact on the magnetic compressor due to CSR

    International Nuclear Information System (INIS)

    When an electron bunch is compressed in a chicane compressor, the CSR (coherent synchrotron radiation) will induce energy redistribution along the bunch. Such energy redistribution will affect the longitudinal emittance as a direct consequence. It will also excite betatron oscillation due to the chromatic transfer functions, and hence a transverse emittance change. So, it is indispensable for us to find a way to alleviate the CSR-caused emittance dilution and the bad result of chicane compressor in PKU-FEL. (authors)

  11. Developing Corporate Strategic Framework to Enhance Sustainability through CSR

    OpenAIRE

    Sapovadia, Vrajlal

    2015-01-01

    CSR activities as applicable under the new company law in India may be used as sustainability strategy by the business. In order to comply with the mandate and with a positive mind set to augment implied benefits thereof, author investigates selected business scenarios to find an optimal pattern of CSR activities that may have long term beneficial impact to the critical stakeholders. This strategic framework propose sustainability model over triple bottom line by addressing holistic issues in...

  12. Corporate-NGO partnerships in CSR activities: why and how?

    OpenAIRE

    Poret, Sylvaine

    2014-01-01

    This article describes, analyzes, and explains the emergence of partnerships between corporations and non-governmental organizations (NGOs) and the ways in which corporations use such relationships as part of their corporate social responsibility (CSR) activities. Economics concepts and the management literature are reviewed, and illustrations are provided to describe such alliances and to explain their expansion. The findings show that firms engage in CSR for altruistic, defensive, and strat...

  13. The effect of culture on businesses' perception of CSR

    OpenAIRE

    Dufays, Frédéric

    2005-01-01

    Numerous interpretations regarding the content, the form, and the rationale for CSR co-exist despite the publication of international codes of conduct such as the U.N. Global Compact. The variety in perceptions of CSR can be explained by a number of factors: individual characteristics such as gender, age, and personal values; organisational characteristics such as firm size and organisational culture; and environmental factors such as industry and national institutions. The latter factor l...

  14. Corporate Social Responsibility (CSR) on Metallurgy Sector in Greece

    OpenAIRE

    Metaxas, Theodore; Tsavdaridou, Maria

    2012-01-01

    Corporate Social Responsibility (CSR) has become one of the most widespread business topics among the academic community. Various issues like environmental pollution, economic crisis, corruption, poverty are of major importance these days and besides governments and politicians’ responsibility it is obvious that corporations are also part of these problems. In Europe the last 15 years, governments, NGOs, small and large enterprises are making an effort to establish in their business CSR strat...

  15. CSR ve vybrané společnosti

    OpenAIRE

    Jakubcová, Lenka

    2013-01-01

    The theme of this thesis is the Corporate Social Responsibility. The theoretical part deals with the basic concepts and principles connected with CSR, its history, Triple Bottom Line structure and the stakeholder analysis. It also describes the available methods for measuring social responsibility and the prizes awarded for the most responsible companies. Finally, it also presents the attitudes of Czech firms and Czech public towards CSR and summarizes the main arguments for and against the c...

  16. CSR, Employee Job Attitude and Behavior: Saudi Bank Experience

    OpenAIRE

    Mohammad Tahlil AZIM; Abdulhamid A. DIYAB; Saleh A. AL-SABAAN

    2014-01-01

    The present study explores the relation- ship between the external CSR practices of the organizations and employees’ job satisfaction, employee engagement and organizational cit- izenship behavior in the context of the Saudi banking industry. A positive relationship between CSR and employee job satisfaction, employee engagement and organizational citizenship be- havior related to the organization is observed. However, the organizational citizenship behavior related to individual is found unre...

  17. Corporate Social Responsibility (CSR): A Scale Development Study in Iran

    OpenAIRE

    Kambiz Heidarzadeh Hanzaee; Amanolla Rahpeima

    2013-01-01

    The present research aims to explore a scale of Corporate Social Responsibility (CSR) in Iran. In this way, it reviews the literature exist on corporate social responsibility, gathers data and analyzes the data to test the emerging trends. After confirmation of reliability, factor analysis and multi dimensional scaling are used to an established survey instrument. Finally CSR was achieved as a construct with five dimensions: obligation to employees, obligation to customers and markets, obliga...

  18. CSR in investor relations: Socially responsible investors and shareholder engagement

    OpenAIRE

    Lipponen, Essi

    2013-01-01

    Abstract OBJECTIVES Shareholders and investors have generally been considered to be stakeholders with limited interest in corporate social responsibility. This trend is changing, as today many investors perceive CSR as a factor that has implications on the bottom line. The main purpose of this study was to examine how CSR is present in investor relations (IR). The focus was on the interaction between socially responsible investors (SRIs) and IR as well as on shareholder engagement. In t...

  19. Strategic CSR Assets within SMEs: A Comparative Case Study

    OpenAIRE

    Elise Bonneveux; Isabelle Calmé; Richard Soparnot

    2012-01-01

    This article aims to show the extent to which strategic organizational resources and assets may determine the type of CSR strategy deployed in SMEs. It is based on the Resource Based View (RBV) approach that allows the authors to propose a theoretical grid to analyse CSR commitment considering the assets mobilized. We have conducted interviews with two SME chief executives with a view to assessing their perception of both internal and external challenges involved in corporate responsibility p...

  20. THE ROLE OF INTERACTIVE TECHNOLOGIES FOR CSR COMMUNICATION

    OpenAIRE

    Gianpaolo Tomaselli; Monia Melia

    2014-01-01

    This work aims to investigate the roles of new interactive technologies to communicate Corporate Social Responsibility (CSR). We adopt the case study method and examine three companies that have successfully approached and developed CSR communication campaigns during the last few years. The study shows how companies use interactive technologies, website and traditional communication channels in integrative ways. Interactive technologies allow more interaction, dialogue and experience sharing....

  1. ISO 26000 som et virkemiddel for institusjonalisering av samfunnsansvar (CSR)

    OpenAIRE

    Ditlev-Simonsen, Caroline D.

    2011-01-01

    Det eksisterer diverse frivillige standarder og verktøy knyttet til bedrifters samfunnsansvar (CSR). Et nytt «skudd på stammen » er ISO 26000 Veiledning om samfunnsansvar. Denne standarden, som er utarbeidet av 500 eksperter fra 40 land, ble lansert i desember 2010. Denne artikkelen presenterer ISO 26000 og vurderer effekten av de viktigste foregående internasjonale standardene og veilederne innen CSR-in...

  2. Multi-channel temperature measurement system for CSR

    International Nuclear Information System (INIS)

    The thesis introduces a multi-channel (64) monitor system of temperature which serves magnetic field safety in CSR. According to the needs of CSR project, the system whose attainable precision is ±1 degree C is able to measure temperature of a few hundred points on magnet windings. This instrument was based on Msp430F149. The research, design and implementation of its hardware and software are particularly described in this thesis. (authors)

  3. Heritage tourism, CSR and the role of employee environmental behaviour.

    OpenAIRE

    Wells, V.; Manika, D.; Gregory-Smith, D.; B. Taheri; McCowlen, C.

    2015-01-01

    Although research on corporate social responsibility (CSR) has grown steadily, little research has focused on CSR at the individual employee level within cultural heritage tourism. This article sheds light on the antecedents of employee environmental behaviour and the effects of a social marketing intervention in a tourism organisation using a mixed methods longitudinal approach. Qualitative results (from 68 respondents) suggest knowledge and awareness of environmental solutions are often lac...

  4. Kommunikationen bag CSR i Novo Nordisk A/S

    OpenAIRE

    Møller, Petra Victoria Akullu; Nygaard, Mette Skytte; Larsen, Kathrine Espander; Eriksen, Rie Christine Søgaard; Bærnholdt, Alexandra Amann

    2016-01-01

    This paper examines how Novo Nordisk disseminates Corporate Social Responsibility (CSR) strategies through selected parts of Novo Nordisk Annual Report 2014. These processes are analyzed with reference to: Louise Phillips’ dialogic communication theory and how it is executed in accordance with Michael E. Porter and Mark R. Kramer’s CSR strategies and R. Edward Freeman’s stakeholder theory. To reinforce these theories a semi-structured interview with the managing director of communication at N...

  5. A Foucauldian investigation of CSR and the concept of responsibility

    OpenAIRE

    Engel, Cecile

    2015-01-01

    Purpose – The dissertation aims to highlight a potential new intellection of CSR – and especially of the concept of responsibility – from CMS theoretical perspectives and Foucault’s theories of sovereignty and governmentality. Design/methodology/approach – The reinterpretation proposed in this paper is based on the denaturalization and subsequent theorization of CSR as an expression of the new spirit of capitalism. The author connects Foucauldian notions of sovereignty and governmentality...

  6. Strategic use of CSR as a signal for good management

    OpenAIRE

    LUIS GOMEZ - MEJIA

    2008-01-01

    More than thirty years of research exploring the link between corporate social responsibility (CSR) and corporate financial performance (CFP) could not provide a satisfying resolution to the tension exists between economic and social objectives. In this paper, we have contributed to the existing CSR literature both theoretically and empirically. On the theoretical side, we challenged the assumption that managers consider all stakeholders equally important and we contend that managers prioriti...

  7. Effect of CSR shielding in the compact linear collider

    CERN Document Server

    Esberg, J; Apsimon, R; Schulte, D

    2014-01-01

    The Drive Beam complex of the Compact Linear Collider must use short bunches with a large charge making beam transport susceptible to unwanted effects of Coherent Synchrotron Radiation emitted in the dipole magnets. We present the effects of transporting the beam within a limited aperture which decreases the magnitude of the CSR wake. The effect, known as CSR shielding, eases the design of key components of the facility.

  8. 3-Tesla MRI Response to TACE in HCC (Liver Cancer)

    Science.gov (United States)

    2016-08-22

    Adult Primary Hepatocellular Carcinoma; Advanced Adult Primary Liver Cancer; Localized Resectable Adult Primary Liver Cancer; Localized Unresectable Adult Primary Liver Cancer; Stage A Adult Primary Liver Cancer (BCLC); Stage B Adult Primary Liver Cancer (BCLC)

  9. Praktyka wdrażania CSR w polskich przedsiębiorstwach w opinii doradców

    OpenAIRE

    Rogowski, Robert

    2016-01-01

    The paper presents the experiences of advisers in implementing the concept of CSR in Polish enterprises. The article presents the results of surveys covering such issues as the implementation of CSR motives and actions taken by operators in the implementation of CSR policies. CSR advisors also identified that companies can use unethical practices. This is also a characteristic of CSR advisors.

  10. Complex regulation of the global regulatory gene csrA: CsrA-mediated translational repression, transcription from five promoters by Eσ70 and EσS, and indirect transcriptional activation by CsrA

    OpenAIRE

    Yakhnin, Helen; Yakhnin, Alexander V.; Baker, Carol S.; Sineva, Elena; Berezin, Igor; Romeo, Tony; Babitzke, Paul

    2011-01-01

    CsrA of Escherichia coli is an RNA binding protein that globally regulates gene expression by repressing translation and/or altering the stability of target transcripts. Here we explored mechanisms that control csrA expression. Four CsrA binding sites were predicted upstream of the csrA initiation codon, one of which overlapped its Shine-Dalgarno sequence. Results from gel shift, footprint, toeprint and in vitro translation experiments indicate that CsrA binds to these four sites and represse...

  11. Evaluation of organ doses in brachytherapy treatment of uterus cancer using mathematical reference Indian adult phantom

    International Nuclear Information System (INIS)

    Quantifying organ dose to healthy organs during radiotherapy is essential to estimate the radiation risk. Dose factors are generated by simulating radiation transport through an anthropomorphic mathematical phantom representing a reference Indian adult using the Monte Carlo method. The mean organ dose factors (in mGy min-1 GBq-1) are obtained considering the Micro Selectron 192Ir source and BEBIG 60Co sources in the uterus of a reference Indian adult female phantom. The present study provides the factors for mean absorbed dose to organs applicable to the Indian female patient population undergoing brachytherapy treatment of uterus cancer. This study also includes a comparison of the dimension of organs in the phantom model with measured values of organs in the various investigated patients. (author)

  12. THE CORPORATE CONSTITUTIONALISM APPROACH IN FORMULATION OF CSR

    Directory of Open Access Journals (Sweden)

    Victor Imanuel Nalle

    2015-04-01

    Full Text Available The 21st century is the era of the development of corporate social responsibility (CSR. It is encouraged by the development of the company as a business and societal entities that balances public and private interests. If there is a balance of public and private interests in the company, the application of CSR should be able to accommodate the public interest. But many companies in Indonesia do not involve the community in the formulation of CSR implementation model. This resulted in the implementation of CSR is often not well targeted. In that context, the theory of corporate constitutionalism becomes relevant theory to answer these problems. The theory of corporate constitutionalism put deliberation as one of the principles to achieve the legitimacy of decision-making in the corporation. Through a process of deliberation formulation of CSR model with the community, not just the interests of shareholders that can be accommodated but also the interests of stakeholders. Thus, CSR can actually be instrumental in the global and local challenges.

  13. CSR Maturity and Motivation in the Water Sector

    DEFF Research Database (Denmark)

    Lauesen, Linne Marie

    2016-01-01

    Purpose: - This paper aims to examine the literature of CSR motivation and presents research results from a case study of the water sector (water companies from Denmark, the UK, the USA and South Africa) and its motivation for and maturity in its CSR work. Design/methodology/approach - The method......Purpose: - This paper aims to examine the literature of CSR motivation and presents research results from a case study of the water sector (water companies from Denmark, the UK, the USA and South Africa) and its motivation for and maturity in its CSR work. Design......-mature according to the proposed CSR Maturity Framework, because it has only reached the level of CSR reporting, but neither suggests definitions of sustainability nor shows any particularly good transparency and accountability yet. Research limitations/implications: - The research is limited to water companies....../methodology/approach - The methodology used in this paper is first a literature review followed by research done with ethnographic methods such as participant observations, interviews and document analysis. Findings: - Based on a literature review and research in water companies motivation and maturity based on Crowther (2006...

  14. CSR - en lönsam utmaning : Hur har begreppet CSR tolkats på företaget Saab?

    OpenAIRE

    Bigestans, Maija; Sävenstedt, Jenny

    2012-01-01

    Behovet av ett gemensamt arbete för ett hållbart samhälle är idag mer påtagligt än någonsin. Begreppet CSR (Corporate Social Responsibility) förekommer ofta i diskussioner om vilken roll företag har i denna process. Då de flesta definitioner av CSR är mycket generella och ger bristande vägledning i utförandet av CSR-arbete finns det ett intresse i att undersöka hur ett företag som säger sig arbeta med CSR har valt att angripa begreppet. Syftet med rapporten var att undersöka hur företaget Saa...

  15. Health behaviors, quality of life, and psychosocial health among survivors of adolescent and young adult cancers

    Science.gov (United States)

    Nam, Gina E.; Zhang, Yingying; McFadden, Molly; Wright, Jennifer; Spraker-Perlman, Holly; Kinney, Anita Y.; Oeffinger, Kevin C.; Kirchhoff, Anne C.

    2016-01-01

    Purpose Survivors of adolescent and young adult (AYA) cancer may engage in unhealthy lifestyles (e.g., smoking), potentially heightening their risk for long-term health problems. We assessed health behaviors and constructs including quality of life (QOL) and psychosocial well-being among survivors of AYA cancer compared to the general population. Methods We used 2009 Behavioral Risk Factor Surveillance System data to evaluate health behaviors for survivors of AYA cancer compared to AYAs without cancer. Multivariable regressions assessed health behaviors (smoking, binge drinking, physical inactivity, and low fruit/vegetable intake) by sex and age between AYA survivors and controls, and among survivors to determine the effects of demographic, QOL, psychosocial, and cancer factors on behaviors. Results A greater proportion of female survivors of AYA cancer smoked than controls (currently aged 20–39: 27 vs. 14.3%, respectively; currently aged 40–64: 29.3 vs. 18.4%, respectively). Generally, survivors and controls were non-adherent to national health behavior guidelines. Uninsured survivors were at greater risk of smoking vs. insured (females, Relative Risk (RR)=1.64, 95 % confidence interval (CI) 1.43–1.90; males, RR=2.62, 95 % CI 1.71–4.02). Poor social/emotional support was associated with smoking (RR= 1.26, 95 % CI 1.07–1.48) among female survivors and was associated with low fruit/vegetable intake among male (RR= 1.12, 95 % CI 1.01–1.23) and female (RR=1.12, 95 % CI 1.05–1.19) survivors. Female survivors >10 years from diagnosis had higher risk of smoking (RR=1.26–1.91, all phealth behavior support. PMID:26248766

  16. Dealing with chemotherapy-related symptoms at home: a qualitative study in adult patients with cancer.

    Science.gov (United States)

    Coolbrandt, A; Dierckx de Casterlé, B; Wildiers, H; Aertgeerts, B; Van der Elst, E; van Achterberg, T; Milisen, K

    2016-01-01

    Given that chemotherapy treatments are done mostly in an outpatient setting, patients with cancer must deal with treatment-related symptoms mainly at home. Evidence suggests that they often feel left alone or unprepared to do so. This qualitative study explores how patients deal with chemotherapy-related symptoms in their home, which factors and ideas influence their self-management and what role professional caregivers play. One-off, semi-structured interviews were held with 28 adult patients with cancer being treated with chemotherapy. Using a Grounded Theory approach, we cyclically collected and analysed data to come to a thorough understanding of the major conceptual themes and their interconnections. Dealing with chemotherapy-related symptoms involves a process of experiencing and learning how side effects unfold over time and how to deal with them. Patients express very personal symptom experiences and symptom-management styles, which are shaped by personal factors (e.g. coping with cancer and cancer treatment, perceived level of control) and environmental factors (e.g. professionals' attitude, information resources). Improving symptom self-management support requires active exploration of the personal symptom experience and symptom-management style. Professional care should be tailored to the patient's perspective and should address personal and environmental determinants of their behaviour. PMID:25752741

  17. Strategies to promote regular exercise in adolescent and young adult cancer survivors

    Directory of Open Access Journals (Sweden)

    Barnes MJ

    2015-11-01

    Full Text Available Margaux J Barnes, Krista Casazza, Heather Austin Department of Pediatrics, Division of General Pediatrics and Adolescent Medicine, University of Alabama at Birmingham (UAB, Birmingham, AL, USA Abstract: Adolescents and young adults (AYAs diagnosed with cancer are at increased risk for current and future health problems and premature death. Given the known risks for increased mortality and morbidity, fostering the development of exercise behaviors that may target the specific late effects experienced by AYA cancer survivors is crucial for healthy aging. Exercise is particularly important in the mitigation of late effects as it alters metabolic pathways that ultimately influence the development of chronic diseases associated with cancer treatment in AYAs. Despite the importance of exercise, a large proportion of AYA survivors do not meet recommended guidelines for exercise. The current review summarizes the beneficial effects of exercise in AYA survivors, evaluates strategies utilized in interventions that have been developed to address exercise engagement, and provides recommendations for psychosocial strategies on how to improve these behaviors in this population. A total of nine empirical articles examining exercise interventions in AYAs with a history of cancer were included for review. While several exercise strategies appear promising, more research is needed to evaluate long-term influence of strategies on exercise engagement, as well as the interactions these strategies have on AYA exercise maintenance and health outcomes as they continue into adulthood. Future interventions should evaluate key psychosocial strategies to increase both short- and long-term exercise adherence as well as overall health benefits. Keywords: oncology, physical activity, adolescents, young adults 

  18. A review of mobile applications to help adolescent and young adult cancer patients

    Directory of Open Access Journals (Sweden)

    Wesley KM

    2015-08-01

    Full Text Available Kimberly M Wesley,1 Philip J Fizur2 1Department of Psychology, St Jude Children's Research Hospital, Memphis, TN, 2Department of Psychology, La Salle University, Philadelphia, PA, USA Objective: To review research articles utilizing mobile applications with adolescent and young adult (AYA cancer patients. Materials and methods: We identified articles via online searches and reference lists (eg, PsycInfo, PubMed. Articles were reviewed by two study team members for target population, stated purpose, technological utilization, sample size, demographic characteristics, and outcome data. Strengths and weaknesses of each study were described. Results: Of 19 identified manuscripts, six met full inclusion criteria for this review (four smartphone applications and two tablet applications. One additional article that included an application not specific to oncology but included AYA patients with cancer within the target sample was also reviewed. Uses of these applications included symptom tracking, pain management, monitoring of eating habits following bone marrow transplant, monitoring of mucositis, and improving medication management. Utility results from pilot studies are presented. Conclusion: Mobile applications are growing in number and increasingly available to AYAs with and without chronic illness. These applications may prove useful in helping to support AYAs throughout their cancer treatment and beyond. However, few applications provide empirical data supporting their utility. Numerous strengths and benefits of these applications include increased accessibility to educational resources and self-management strategies, more frequent physical and emotional symptom tracking, and increased access to peer support. Despite these strengths, numerous limitations are identified, highlighting the need for future research in this area. Keywords: adolescent, young adult, cancer, smartphone, mobile, applications

  19. The Balance between Internally and Externally Oriented CSR - A case study of Danish SMEs

    DEFF Research Database (Denmark)

    Aagaard, Annabeth; Lemmergaard, Jeanette

    -sized companies, SMEs. This study explores how four Danish SMEs have integrated CSR, and how the levels of external, internal and diagonal integration affect the qualitative and quantitative results of CSR. Whereas external CSR integration constitutes the external CSR communication and involvement of customers......, suppliers and other stakeholders, the internal CSR integration is explained and measured through the level of employee involvement and the content and the effects of internal oriented CSR activities and communication. The diagonal integration is understood as integration with the business strategy.......Corporate social responsibility (CSR) has become an acknowledged and well-established strategic approach in both theory and practice. A large majority of the existing literature emphasises CSR integration within larger corporations, although CSR also plays a pivotal role in small to medium...

  20. Corporate Social Responsibility (CSR Effectiveness in the Greek Professional Sport Context

    Directory of Open Access Journals (Sweden)

    John Douvis

    2015-03-01

    Full Text Available The present study examined CSR evaluation issues regarding the effectiveness of CSR activities in Greek professional sport organizations. The initial results illustrated a general absence of CSR effectiveness evaluation. The findings of the study revealed that the majority of respondents have reported that in fact CSR performance is not measured mainly because of a lack of a methodology or a common framework. A major barrier to CSR assessment and evaluation practices is represented by the respondents’ perceptions with respect to the nature of CSR. However, executives and managers mentioned a range of estimations to assess the impacts of their CSR actions, thus CSR effectiveness underlies subjective assessments of positive effect observations. Based on the results and the literature, the present study discusses the implications regarding the issue of CSR measurement and evaluation in Greek professional sport organizations.

  1. CSR AND SUSTAINABILITY: AN INVESTIGATION INTO THE PRACTICE OF ONLINE CSR INITIATIVES BY SECONDARY MARKET LISTED COMPANIES IN MALAYSIA

    OpenAIRE

    Nazahah Abd Rahim

    2013-01-01

    Corporate social responsibility (CSR) initiatives are being approached by corporations in so many ways and the most common in forms of campaigns, printed brochures, posters and sponsorships. This is becoming a problem because when corporations use existing resources to carry out their CSR initiatives, sometimes they are being carried away as not to think about whether they are going to have enough resources for future use, so as to become sustainable. But, there is another way of how corporat...

  2. The Strategic Value of Corporate Social Responsibility (CSR): Leveraging WSP Group’s CSR Strategy to Implement Its Sustainability Policy

    OpenAIRE

    Iskender, Khatira

    2010-01-01

    Through its impact on the built environment, construction plays a central role in the UK government’s drive to promote sustainable growth and development. Therefore, Corporate Social Responsibility (CSR) has become a growing area of interest for engineering and design consulting firms, such as WSP, within the construction industry as their stakeholder bases expand and expectations regarding the firm’s conduct also rise. This paper investigates WSP’s approach to CSR by addressing the following...

  3. A comparative content analysis of CSR strategies oriented to environmental issues between Greek and European CSR practices

    OpenAIRE

    Metaxas, Theodore; Tsavdaridou, Maria

    2011-01-01

    The scope of this research is to examine the way Greek companies contribute to the protection of the environment by investigating the CSR reports. In addition, there will be a comparative content analysis of Greek and European companies which will focus on the environmental aspect of the companies CSR strategy. Issues like recycling, environmental awareness, restoration of abandon places like quarrying, energy conservation, environmental education, green buildings, appliance of environmental ...

  4. A narrative review of the occurrence of posttraumatic stress responses in adolescent and young adult cancer survivors

    Directory of Open Access Journals (Sweden)

    Vuotto SC

    2015-02-01

    Full Text Available Stefanie C Vuotto,1 Katia M Perez,2 Kevin R Krull,1 Tara M Brinkman1 1Department of Epidemiology and Cancer Control, St Jude Children’s Research Hospital, Memphis, 2Department of Psychology and Human Development, Vanderbilt University, Nashville, TN, USA Abstract: Adolescent and young adult cancer survivors may experience posttraumatic stress responses following cancer diagnosis or treatment. The current paper reviews 23 studies reporting the occurrence of posttraumatic stress symptoms (PTSS and posttraumatic stress disorder (PTSD, and associated predictors of these outcomes in adolescent and young adult cancer survivors. Results indicate considerable variability among prevalence estimates of PTSD (0%–34.8% and PTSS (4.4%–78%. Measurement inconsistencies limiting the ascertainment of reliable prevalence and risk estimates are discussed in the context of the reviewed literature. Specifically, differences in assessment measures utilized, the timing of assessment relative to diagnosis, the criteria used to define the outcome, and identification of the precipitating traumatic event may account for discrepancies in prevalence and risk estimates across studies. The application of specific PTSD diagnostic criteria to a survivorship population is discussed. Empirically supported interventions utilizing cognitive behavioral therapy approaches for the treatment of PTSS in adolescent and young adult cancer survivors are identified. Keywords: posttraumatic stress, adolescent and young adult, cancer survivors

  5. In silico identification and experimental characterization of regulatory elements controlling the expression of the Salmonella csrB and csrC genes.

    Science.gov (United States)

    Martínez, Luary C; Martínez-Flores, Irma; Salgado, Heladia; Fernández-Mora, Marcos; Medina-Rivera, Alejandra; Puente, José L; Collado-Vides, Julio; Bustamante, Víctor H

    2014-01-01

    The small RNAs CsrB and CsrC of Salmonella indirectly control the expression of numerous genes encoding widespread cellular functions, including virulence. The expression of csrB and csrC genes, which are located in different chromosomal regions, is coordinated by positive transcriptional control mediated by the two-component regulatory system BarA/SirA. Here, we identified by computational analysis an 18-bp inverted repeat (IR) sequence located far upstream from the promoter of Salmonella enterica serovar Typhimurium csrB and csrC genes. Deletion analysis and site-directed mutagenesis of the csrB and csrC regulatory regions revealed that this IR sequence is required for transcriptional activation of both genes. Protein-DNA and protein-protein interaction assays showed that the response regulator SirA specifically binds to the IR sequence and provide evidence that SirA acts as a dimer. Interestingly, whereas the IR sequence was essential for the SirA-mediated expression of csrB, our results revealed that SirA controls the expression of csrC not only by binding to the IR sequence but also by an indirect mode involving the Csr system. Additional computational, biochemical, and genetic analyses demonstrated that the integration host factor (IHF) global regulator positively controls the expression of csrB, but not of csrC, by interacting with a sequence located between the promoter and the SirA-binding site. These findings contribute to the better understanding of the regulatory mechanism controlling the expression of CsrB and CsrC.

  6. In silico identification and experimental characterization of regulatory elements controlling the expression of the Salmonella csrB and csrC genes.

    Science.gov (United States)

    Martínez, Luary C; Martínez-Flores, Irma; Salgado, Heladia; Fernández-Mora, Marcos; Medina-Rivera, Alejandra; Puente, José L; Collado-Vides, Julio; Bustamante, Víctor H

    2014-01-01

    The small RNAs CsrB and CsrC of Salmonella indirectly control the expression of numerous genes encoding widespread cellular functions, including virulence. The expression of csrB and csrC genes, which are located in different chromosomal regions, is coordinated by positive transcriptional control mediated by the two-component regulatory system BarA/SirA. Here, we identified by computational analysis an 18-bp inverted repeat (IR) sequence located far upstream from the promoter of Salmonella enterica serovar Typhimurium csrB and csrC genes. Deletion analysis and site-directed mutagenesis of the csrB and csrC regulatory regions revealed that this IR sequence is required for transcriptional activation of both genes. Protein-DNA and protein-protein interaction assays showed that the response regulator SirA specifically binds to the IR sequence and provide evidence that SirA acts as a dimer. Interestingly, whereas the IR sequence was essential for the SirA-mediated expression of csrB, our results revealed that SirA controls the expression of csrC not only by binding to the IR sequence but also by an indirect mode involving the Csr system. Additional computational, biochemical, and genetic analyses demonstrated that the integration host factor (IHF) global regulator positively controls the expression of csrB, but not of csrC, by interacting with a sequence located between the promoter and the SirA-binding site. These findings contribute to the better understanding of the regulatory mechanism controlling the expression of CsrB and CsrC. PMID:24187088

  7. Campylobacter jejuni CsrA complements an Escherichia coli csrA mutation for the regulation of biofilm formation, motility and cellular morphology but not glycogen accumulation

    Directory of Open Access Journals (Sweden)

    Fields Joshua A

    2012-10-01

    Full Text Available Abstract Background Although Campylobacter jejuni is consistently ranked as one of the leading causes of bacterial diarrhea worldwide, the mechanisms by which C. jejuni causes disease and how they are regulated have yet to be clearly defined. The global regulator, CsrA, has been well characterized in several bacterial genera and is known to regulate a number of independent pathways via a post transcriptional mechanism, but remains relatively uncharacterized in the genus Campylobacter. Previously, we reported data illustrating the requirement for CsrA in several virulence related phenotypes of C. jejuni strain 81–176, indicating that the Csr pathway is important for Campylobacter pathogenesis. Results We compared the Escherichia coli and C. jejuni orthologs of CsrA and characterized the ability of the C. jejuni CsrA protein to functionally complement an E. coli csrA mutant. Phylogenetic comparison of E. coli CsrA to orthologs from several pathogenic bacteria demonstrated variability in C. jejuni CsrA relative to the known RNA binding domains of E. coli CsrA and in several amino acids reported to be involved in E. coli CsrA-mediated gene regulation. When expressed in an E. coli csrA mutant, C. jejuni CsrA succeeded in recovering defects in motility, biofilm formation, and cellular morphology; however, it failed to return excess glycogen accumulation to wild type levels. Conclusions These findings suggest that C. jejuni CsrA is capable of efficiently binding some E. coli CsrA binding sites, but not others, and provide insight into the biochemistry of C. jejuni CsrA.

  8. CSR:以责任为名%CSR Becoming a Key Factor for Enterprise

    Institute of Scientific and Technical Information of China (English)

    慕名

    2009-01-01

    @@ "天堂不是建筑在公司的损益表上面,而是建在每个人尽责服务上面."虽然是上世纪20年代的一句话,但因为其拉开了CSR(Corporate social responsibility,即企监社会责任) "进化史"的大幕这一特殊意义而被后人屡屡提起.而且从当下来看,CSR受关注的程度更是与日俱增,越来越成为一个全球性的话题.

  9. A Novel CSR-Based Sparse Matrix-Vector Multiplication on GPUs

    OpenAIRE

    Guixia He; Jiaquan Gao

    2016-01-01

    Sparse matrix-vector multiplication (SpMV) is an important operation in scientific computations. Compressed sparse row (CSR) is the most frequently used format to store sparse matrices. However, CSR-based SpMVs on graphic processing units (GPUs), for example, CSR-scalar and CSR-vector, usually have poor performance due to irregular memory access patterns. This motivates us to propose a perfect CSR-based SpMV on the GPU that is called PCSR. PCSR involves two kernels and accesses CSR arrays in ...

  10. Implementation of CSR concept in manufacturing SMEs

    Directory of Open Access Journals (Sweden)

    Szczanowicz Justyna

    2014-05-01

    Full Text Available W artykule podejmuje się próbę zaproponowania modelu wdrażania koncepcji społecznej odpowiedzialności biznesu w małych i średnich przedsiębiorstwach produkcyjnych. Na podstawie badań PARP przedstawia się problem jakim jest słaba kondycja SCR w sektorze MSP. Sugeruje się podejście w którym kluczowym aspektem są poziomy społecznej odpowiedzialności biznesu rozumiane jako fundamenty na których przedsiębiorstwo nadbudowuje swoją konkurencyjność. W pracy podkreśla się również inwestycję w praktyki istotne z punktu widzenia kluczowych interesariuszy celem zwiększenie efektywności działań CSR rozumianych jako podniesienie konkurencyjności przedsiębiorstwa.

  11. Cancer and frailty in older adults: a nested case-control study of the Mexican Health and Aging Study

    Science.gov (United States)

    Pérez-Zepeda, Mario Ulises; Cárdenas-Cárdenas, Eduardo; Cesari, Matteo; Navarrete-Reyes, Ana Patricia; Gutiérrez-Robledo, Luis Miguel

    2016-01-01

    Purpose Understanding how the convergence between chronic and complex diseases—such as cancer—and emerging conditions of older adults—such as frailty—takes place would help in halting the path that leads to disability in this age group. The objective of this manuscript is to describe the association between a past medical history of cancer and frailty in Mexican older adults. Methods This is a nested in cohort case-control study of the Mexican Health and Aging Study. Frailty was categorized by developing a 55-item frailty index that was also used to define cases in two ways: incident frailty (incident >0.25 frailty index score) and worsening frailty (negative residuals from a regression between 2001 and 2012 frailty index scores). Exposition was defined as self-report of cancer between 2001 and 2012. Older adults with a cancer history were further divided into recently diagnosed (10 years from the initial diagnosis). Odds ratios were estimated by fitting a logistic regression adjusted for confounding variables. Results Out of a total of 8022 older adults with a mean age of 70.6 years, the prevalence of a past medical history of cancer was 3.6 % (n = 288). Among these participants, 45.1 % had been diagnosed with cancer more than 10 years previously. A higher risk of incident frailty compared to controls [odds ratio (OR) 1.53 (95 % confidence interval (CI) 1.04–2.26, p = 0.03); adjusted model OR 1.74 (95 % CI 1.15–2.61, p = 0.008)] was found in the group with a recent cancer diagnosis. Also, an inverse association between a remote cancer diagnosis and worsening frailty was found [OR = 0.56 (95 % CI 0.39–0.8), p = 0.002; adjusted model OR 0.61 (95 % CI 0.38–0.99, p = 0.046)]. Conclusions Cancer is associated with a higher frailty index, with a potential relevant role of the time that has elapsed since the cancer diagnosis. Implications for cancer survivors Cancer survivors may be more likely to develop frailty or worsening of the health status at an

  12. 企业社会责任研究——CSR,CSR2,CSP

    Institute of Scientific and Technical Information of China (English)

    王新新; 杨德锋

    2007-01-01

    企业社会责任作为国外研究的热点,已有很长的历史,研究的中心几经转移.因企业社会责任(CSR)没有指明企业如何做社会事务,产生了企业社会响应(CSR2),因CSR对社会责任的概括不够全面,产生了企业社会绩效(CSP).对于企业为何要承担社会责任,学者们主要从工具理论等四个大的理论方面给予解释.企业承担社会责任,能够使企业获得一定的竞争优势,并且大部分的实证研究支持CSP和CFP正相关的结论.

  13. Magnetic resonance characteristics of adult-onset Lhermitte-Duclos disease: An indicator for active cancer surveillance?

    OpenAIRE

    Wei, Guangquan; Zhang, Wei; Li, Qinlong; KANG, XIAOWEI; Zhao, Haitao; LIU, XIANPING; Tang, Xing; Wu, Yuanming; HAN, JUNTAO; Yin, Hong

    2014-01-01

    Lhermitte-Duclos disease (LDD) is a rare, non-cancerous entity characterized by enlarged, abnormally developed cerebellar folia containing dysplastic cells. Symptomatic LDD is commonly observed in adults (adult-onset LDD, aLDD) as an isolated condition or associated with Cowden’s disease (CD). The present study aimed to investigate the magnetic resonance imaging (MRI) characteristics and the underlying pathological findings in 7 cases of aLDD, with emphasis on the association with CD and the ...

  14. Teenagers and young adults with cancer in Europe: from national programmes to a European integrated coordinated project

    DEFF Research Database (Denmark)

    Stark, D; Bielack, S; Brugieres, L;

    2016-01-01

    Over 14 000 patients aged 15-24 are estimated to be diagnosed with cancer in the European Union (EU) each year. Teenagers and young adults (TYA) often fall down gaps between children's and adults cancer services. The specific challenges of providing optimal care to them are described, but we...... present a summary of recent progress. Progress to overcome these challenges is happening at different rates across Europe. We summarise the European national projects in this field but more recently we have seen the beginnings of European coordination. Within the EU 7th Funding Programme (FP7) European...

  15. Cancer treatment and gonadal function : experimental and established strategies for fertility preservation in children and young adults

    OpenAIRE

    Anderson, Richard A.; Mitchell, Rod T.; Kelsey, Tom; Spears, Norah; Telfer, Evelyn E.; Wallace, W Hamish B

    2015-01-01

    Preservation of gonadal function,is an important priority for the long-term health of cancer survivors of both sexes and all ages at treatment.. The loss of an opportunity for fertility is a prime concern in both male and female cancer survivors, however the endocrine consequences of gonadal damage are also central to long-term health and wellbeing. Some fertility preservation techniques, such as semen and embryo cryopreservation for the adult man and woman respectively, are established and s...

  16. The Use of Complementary and Alternative Medicine Among California Adults With and Without Cancer

    Directory of Open Access Journals (Sweden)

    Michael S Goldstein

    2005-01-01

    Full Text Available This article examines the extent and correlates of complementary and alternative medicine (CAM use among a population-based sample of California adults that is highly diverse in terms of sociodemographic characteristics and health status. As a follow-up to a state-wide health survey of 55 428 people, 9187 respondents were interviewed by phone regarding their use of 11 different types of CAM providers, special diets, dietary supplements, mind–body interventions, self-prayer and support groups. The sample included all participants in the initial survey who reported a diagnosis of cancer, all the non-white respondents, as well as a random sample of all the white respondents. The relation of CAM use to the respondents' demographic characteristics and health status is assessed. CAM use among Californians is generally high, and the demographic factors associated with high rates of CAM use are the same in California as have been found in other studies. Those reporting a diagnosis of cancer and those who report other chronic health problems indicate a similar level of visits to CAM providers. However, those with cancer are less likely to report using special diets, and more likely to report using support groups and prayer. Health status, gender, ethnicity and education have an independent impact upon CAM use among those who are healthy as well as those who report suffering from chronic health problems, although the precise relation varies by the type of CAM used.

  17. Psychosocial interventions for adolescents and young adult cancer patients: A systematic review and meta-analysis.

    Science.gov (United States)

    Richter, Diana; Koehler, Michael; Friedrich, Michael; Hilgendorf, Inken; Mehnert, Anja; Weißflog, Gregor

    2015-09-01

    Adolescent and young adult (AYA) cancer patients experience unique psychosocial needs and developmental challenges. A cancer diagnosis can stress this development and disrupt AYAs in their normal life. The aim of this systematic review and meta-analysis was to assess the impact of psychosocial interventions on mental health in AYAs. A literature research was conducted, which resulted in twelve eligible studies. The standardized mean difference between intervention and control conditions was 0.13 (95% CI: -0.16 to 0.42) for quality of life, 0.27 (95% CI: -0.22 to 0.76) for cancer-related knowledge and -0.16 (95% CI: -0.73 to 0.42) on psychological distress indicating, small and non-significant effects for interventions improving mental health. This work strengthens the need for age-appropriated interventions in psycho-oncology. Future research should develop interventions more graduated by age. Randomized intervention studies with larger samples and focusing psychosocial outcomes are needed to establish evidence-based psycho-oncological interventions for AYAs.

  18. Low energy electron cooler for the Heidelberg CSR

    International Nuclear Information System (INIS)

    The cryogenic storage ring (CSR) is currently under development at MPI-K in Heidelberg. The CSR is an electrostatic ring intended for storing ions in the 20-300 keV energy range (E/Q) in cryogenic environment at temperature down to 2 K. CSR will be equipped with an electron cooler which has to combine cooler and electron target functions. For cooling operation at given ion energies corresponding electron energies are in the range from 160 down to a few eV. Main problems in such operation mode are the decrease of electron beam intensity, the degradation of the electron longitudinal energy spread and the distortion of stored low energy ion trajectories during beams merging. For the CSR a new merging beam section layout together with a photocathode based cold electron source (tested at the Heidelberg TSR) have been proposed. In this paper we present the design of CSR electron cooler including the cryogenic implementation together with numerical calculations of the electron beam longitudinal and transverse energy spread in merged beam section

  19. Using CSR to mitigate information asymmetry in the banking sector

    Directory of Open Access Journals (Sweden)

    Semenescu Andreea

    2015-12-01

    Full Text Available The paper examines the power of corporate social responsibility to reduce information asymmetry and to act as a marketing instrument in the banking sector. Trust is the most important asset of a bank. Therefore, banks are motivated to use the most effective instruments to diminish information asymmetry with their stakeholders. The fact that cash disbursements in CSR actions are not directed towards shareholders makes them more valuable signals to other stakeholders regarding the financial soundness of the bank. The empirical study conducted based on limited dependent variable models supports the effectiveness of the CSR as marketing instrument in banking. It reveals the circumstances associated to a higher probability of an active CSR policy conducted by a banking institution. The results support the hypothesis that in the banking sector CSR is perceived as an instrument which helps stakeholders reduce information asymmetry. As marketing instrument, CSR contributes to increasing the tangibility of the banking products, decreasing their perceived variability and thus making them more attractive for the clients and allowing for differentiation between competitors.

  20. The integration of corporate social responsibility (CSR) initiatives into business activities

    DEFF Research Database (Denmark)

    Knudsen, Jette Steen

    2013-01-01

    While proponents of corporate social responsibility (CSR) have suggested that CSR initiatives should be integrated into mainstream business activities as 'strategic CSR' or 'shared value', research is lacking that explores how CSR programmes are integrated in companies. This paper compares CSR...... initiatives with human resource management (HRM) activities, which have a longer tradition of being integrated into company strategy. The focus is on gender diversity and CSR in a US multinational corporation (MNC). The MNC sees gender diversity as an integral part of business activities. In contrast, the MNC...... lacks a clear justification for the much broader CSR agenda, CSR activities seem not to reflect an overall set of values or purpose, integration into business activities is unclear, and targets are lacking....

  1. csrT Represents a New Class of csrA-Like Regulatory Genes Associated with Integrative Conjugative Elements of Legionella pneumophila

    Science.gov (United States)

    Abbott, Zachary D.; Flynn, Kaitlin J.; Byrne, Brenda G.; Mukherjee, Sampriti; Kearns, Daniel B.

    2015-01-01

    ABSTRACT Bacterial evolution is accelerated by mobile genetic elements. To spread horizontally and to benefit the recipient bacteria, genes encoded on these elements must be properly regulated. Among the legionellae are multiple integrative conjugative elements (ICEs) that each encode a paralog of the broadly conserved regulator csrA. Using bioinformatic analyses, we deduced that specific csrA paralogs are coinherited with particular lineages of the type IV secretion system that mediates horizontal spread of its ICE, suggesting a conserved regulatory interaction. As a first step to investigate the contribution of csrA regulators to this class of mobile genetic elements, we analyzed here the activity of the csrA paralog encoded on Legionella pneumophila ICE-βox. Deletion of this gene, which we name csrT, had no observed effect under laboratory conditions. However, ectopic expression of csrT abrogated the protection to hydrogen peroxide and macrophage degradation that ICE-βox confers to L. pneumophila. When ectopically expressed, csrT also repressed L. pneumophila flagellin production and motility, a function similar to the core genome's canonical csrA. Moreover, csrT restored the repression of motility to csrA mutants of Bacillus subtilis, a finding consistent with the predicted function of CsrT as an mRNA binding protein. Since all known ICEs of legionellae encode coinherited csrA-type IV secretion system pairs, we postulate that CsrA superfamily proteins regulate ICE activity to increase their horizontal spread, thereby expanding L. pneumophila versatility. IMPORTANCE ICEs are mobile DNA elements whose type IV secretion machineries mediate spread among bacterial populations. All surveyed ICEs within the Legionella genus also carry paralogs of the essential life cycle regulator csrA. It is striking that the csrA loci could be classified into distinct families based on either their sequence or the subtype of the adjacent type IV secretion system locus. To

  2. Effects of Core-Shell Rubber (CSR) Nanoparticles on the Cryogenic Fracture Toughness of CSR Modified Epoxy

    Science.gov (United States)

    Wang, Jun; Magee, Daniel; Schneider, Judy; Cannon, Seth

    2009-01-01

    This study investigated the effects of core-shell rubber (CSR) nanoparticles on the mechanical properties and fracture toughness of an epoxy resin at ambient and liquid nitrogen (LN2) temperatures. Varying amounts of Kane Ace(Registered TradeMark) MX130 and Kane Ace(Registered TradeMark) MX960 toughening agent were added to a commercially available EPON 862/Epikure W epoxy resin. Elastic modulus was calculated using quasi-static tensile data. Fracture toughness was evaluated by the resulting breaking energy measured in Charpy impact tests conducted on an instrumented drop tower. The size and distribution of the CSR nanoparticles were characterized using Transmission Electron Microscopy (TEM) and Small Angle X-ray Scattering (SAXS). Scanning Electron Microscopy (SEM) was used to study the fracture surface morphology. The addition of the CSR nanoparticles increased the breaking energy with negligible change in elastic modulus and ultimate tensile stress (UTS). At ambient temperature the breaking energy increased with increasing additions of the CSR nanoparticles up to 13.8wt%, while at LN2 temperatures, it reached a plateau at much lower CSR concentration.

  3. PENGARUH PENERAPAN CORPORATE SOCIAL RESPONSIBILITY ( CSR ) TERHADAP CITRA PERUSAHAAN PADA PT. HADJI KALLA CABANG SULTAN ALAUDDIN

    OpenAIRE

    MAJID, PARAMITA

    2012-01-01

    - This research aims to determine the influence either together or partially between CSR (Corporate Social Responsibility) to corporate image in PT. Hadji Kalla Cabang Sultan Alaudin, Makassar area, that being measured from CSR variables which is Profit, People, and Planet. Expectedly the information obtained from this research can be used by companies to increase CSR activities and quality of CSR programs so that more can enh...

  4. Comparative Study of CSR reporting in Finnish and UK listed Companies

    OpenAIRE

    Aryal, Nabin

    2014-01-01

    This is the comparative study of CSR reporting in Finnish and UK listed companies. This thesis provides user with knowledge on Corporate Social Responsibility (CSR) reporting and shows the comparative study on how CSR reporting is carried out in Finnish and UK listed companies. This study is carried out using qualitative study. In order to know the reporting pattern in Finland and UK three listed companies from both the countries are selected and their CSR reports have been analyzed. The aim ...

  5. Web communication of CSR and financial performance: Study applied to catalan meat companies

    OpenAIRE

    Alejandra Aramayo García; Nuria Arimany-Serrat; Clara Uribe Salazar; Anna Sabata Aliberch

    2016-01-01

    Purpose: Understanding the relationship between CSR communication on corporate websites and the financial performance of Catalan meat companies. Design/methodology/approach: Qualitative and quantitative analysis of the CSR communication variables of corporate websites identifying the companies with the best CSR web communication’s practices, and economic and financial comparative analysis. It also modelled the financial returns to determine whether CSR communication, as an independent vari...

  6. CSR strategie jako součást marketingové komunikace

    OpenAIRE

    Pospíšilová, Lucie

    2014-01-01

    The main goal of this diploma thesis is to propose a long-term CSR strategy for selected company, primarily focused on social pillar and putting emphasis on its communication. The CSR strategy is proposed based on evaluation of current company's CSR activities, concerning criteria of new global CSR concept of the company, as well as reflecting consumer's perspective and their perception of selected company's brand. Furthermore, the strategy works with local market and social specifics and gen...

  7. Examining online CSR communication within the auditing and consulting industry: the big 4 companies

    OpenAIRE

    Larnemaa, Anne

    2013-01-01

    Objectives of the Study First, the purpose of this study was to examine the online CSR communication of the Finnish Big 4 companies, that is KPMG, PwC, Deloitte and Ernst & Young (EY). The aim was to identify what these companies understand as "CSR" and how they communicate about responsibility issues online. Second, this study examined the online CSR communication of Ernst & Young on a global level and found out what kind of a global CSR communication strategy Ernst & Young has developed...

  8. CSR Communication Strategies for Twitter : Microblogging as a Tool for Public Relations

    OpenAIRE

    Etter, Michael; Plotkowiak, Thomas; Stanoevska-Slabeva, Katarina

    2011-01-01

    This study explores how companies use the social media tool Twitter for CSR communication. By analyzing CSR communication conducted by 30 most central corporate Twitter accounts, identified through social network analysis within a CSR-Twitter-network consisting of 19'855 Twitter members, we contribute to the understanding of Twitter's role for CSR communication and public relations. Manually conducted content analysis of totally 41‘864 corporate Twitter messages gives insights into different ...

  9. Corporate Social Responsibility (CSR) and Sustainability in Asian Luxury Hotels: Policies, Practices and Standards

    OpenAIRE

    Vimolboon Cherapanukorn; Kirsten Focken

    2014-01-01

    The tourism and hospitality industry claims to embrace the concept of corporate social responsibility (CSR) but it seems unclear how and if companies integrate CSR activities into the core business and how they demonstrate real impacts and positive changes. The purpose of this research is to understand how Asian luxury hotels communicate about their CSR policies, practices and standards. It gives insights of best practices of CSR from luxury hotel groups that operate predominantly in Asia. Th...

  10. Analýza CSR ve vybrané firmě

    OpenAIRE

    Hořejší, Renata

    2012-01-01

    This thesis deals with Corporate Social Responsibility. In the theoretical part the basic concepts of Corporate Social Responsibility are determined and introduced initiatives dealing with CSR at national, European and global level. The definition of methods for measuring CSR, communication, implementation and benefits of CSR for the company are also included in this part. The practical part is focused on the company Skupina ČEZ. There is company presentation, particular CSR activities and re...

  11. Sustainability in the Tobacco Sector? A Comparative Study of CSR Activities in Vietnam and the UK

    OpenAIRE

    Trinh, Ngoc Huyen

    2013-01-01

    Since controversial industry sectors started to conduct corporate social responsibility (CSR) initiatives and promote themselves as socially responsible citizens, it becomes phenomenon that critical non-governmental organizations (NGOs) react to CSR communication by highlighting the shortcomings of CSR activities; especially what infringe the ethical stances. Moving beyond the moral argument and ethical-based values that portray the debates underpinning CSR concepts and ideas, this work aims ...

  12. Understanding strategic corporate social responsibility (CSR) in Finnish consumer goods industry

    OpenAIRE

    Kuusela, Nina

    2015-01-01

    Objectives: The main objective of the study is to understand how the various elements of strategic Corporate Social Responsibility (CSR) are utilized as a source of differentiation, and even as a competitive advantage for a company. The study explores the different company approaches to CSR, and widens the understanding of strategic CSR through a Finnish case company that aims to utilize CSR as a competitive advantage. The theoretical background of this study lies in academic literature a...

  13. The Flavour of CSR in Indonesia: A comparative study of 3 Indonesian State-Owned Banks

    OpenAIRE

    Sapphira, Anya Sapphira

    2011-01-01

    CSR has been recognized in Indonesia for the past decade, and it keeps developing. Together with other developing countries in Asia, Indonesia shows more attention on the issue of CSR and its implementation. A significant step related to CSR in Indonesia is when the government of Indonesia released the Social and Environmental Responsibility (TJSL) regulation in 2007. Although until now, the regulation has not been equipped with practical standard such as government regulation, on CSR definit...

  14. How CSR creates value for mutual insurers: a strategic-economic model for managers

    OpenAIRE

    Lageu, Faye

    2009-01-01

    Over the last 20 years, corporate social responsibility (CSR) has worked its way up the business and political agenda. Evidence of firms’ increased CSR investments are not matched,however, by clear evidence of how CSR creates value for firms. As recession takes hold,managers will increasingly be required to review their inputs and outputs and consider how their various resource allocations create value. That some firms invest in CSR suggests it can provide a competitive advantage; yet...

  15. HVORDAN INTEGRERES CSR I SMÅ OG MELLEMSTORE VIRKSOMHEDER OG HVAD PÅVIRKER INTEGRATIONSFORMEN?

    DEFF Research Database (Denmark)

    Aagaard, Annabeth

    2016-01-01

    CSR integration i små og mellemstore virksomheder (SMV’er) mangelfuld, og flere studier påpeger at der er væsentlig forskel på CSR og CSR integration når man sammenligner store virksomheder og SMV’er. Denne artikel ønsker at undersøge, hvordan små og mellemstore virksomheder integrerer CSR og hvad der...

  16. The Danish CSR Reporting Requirement as Reflexive Law

    DEFF Research Database (Denmark)

    Buhmann, Karin

    2013-01-01

    With effect for financial years beginning January 2009 or later, the Danish Financial Statements Act and related governmental regulations require large Danish companies and institutional investors to submit an annual Corporate Social Responsibility (CSR) report. Through application of reflexive law...... theory and an analysis of the preparatory works and guidelines for the CSR-reporting requirement, this article demonstrates that the reporting requirement aims to obtain public policy objectives through stimulating companies to self-regulate based on reflection on their impact on society. The legislative...... history and reporting guidelines indicate a definite objective of drawing on the CSR paradigm to complement national substantive law, engaging company practice in the implementation of national public policy goals and in the extraterritorial implementation of public policy goals related to conditions...

  17. The injection beam lines of the cryogenic storage ring (CSR)

    International Nuclear Information System (INIS)

    At the Max-Planck-Institute for Nuclear Physics in Heidelberg an electrostatic cryogenic storage ring (CSR) is under construction. The ions for the CSR will be provided by two ion sources with up to 60kV and 300 kV potential, respectively. The layout of the beamlines connecting the ion sources with the CSR is presented. They will be merged using an electrostatic deflector with an opening in the outer electrode, thereby allowing quick switching between the two ion sources. In order to determine the influence of the opening on the beam optics the deflector has been modeled and a modified transport matrix has been derived. An additional beamline element is a detachment region for the neutralization of a negative ion beam by photodetachment. The potential of the detachment region defines the precise energy of the neutral particles. Calculations of the ion beam optics using the MAD X code are described.

  18. Observation of CSR spectrum from JAEA-ERL

    International Nuclear Information System (INIS)

    The energy recovery linac (ERL) is able to generate high-power coherent synchrotron radiation (CSR) in the terahertz and the millimeter-wave regions, because it produces shorter bunches than usual storage rings and a higher current than conventional linacs. The spectrum of CSR has been measured at the JAEA-ERL in the wavenumber range from 0.5 to 15cm-1. The detected power was 2x10-4 W/cm-1 at 2.5 cm-1 for the average beam current of 17.7 μA. When the infrared FEL was operated with the undulator in the ERL, the CSR spectrum was shifted to the longer wavelengths because of the energy broadening of the electron beam. (author)

  19. "Perhaps I will die young." Fears and worries regarding disease and death among Danish adolescents and young adults with cancer

    DEFF Research Database (Denmark)

    Hølge-Hazelton, Bibi; Timm, Helle U.; Graugaard, Christian;

    2016-01-01

    Purpose: A cross-sectional national study was initiated in order to evaluate healthcare services and survivorship from the perspective of Danish adolescents and young adults (AYAs) with cancer. The purpose of the paper was to examine (Q1) to what extend Danish AYAs experienced fears and worries a...

  20. Factors contributing to posttraumatic growth and its buffering effect in adult chidren of cancer patients undergoing treatment

    OpenAIRE

    Teixeira, Ricardo João; Pereira, M. Graça

    2013-01-01

    This study examined relationships among demographic, clinical, and psychosocial variables in adult children of cancer patients. Two hundred and fourteen participants completed measures of posttraumatic growth (PTG), distress, posttraumatic stress disorder (PTSD) symptoms, social support, and family functioning. Significant gender differences in all PTG dimensions were found, as well as associations among PTG, gender, parental dependency, distress, PTSD, and family functio...

  1. Variation in the group B Streptococcus CsrRS regulon and effects on pathogenicity

    NARCIS (Netherlands)

    Jiang, Sheng-Mei; Ishmael, Nadeeza; Hotopp, Julie Dunning; Puliti, Manuela; Tissi, Luciana; Kumar, Nikhil; Cieslewicz, Michael J.; Tettelin, Herve; Wesselsl, Michael R.

    2008-01-01

    CsrRS (or CovRS) is a two-component regulatory system that controls expression of multiple virulence factors in the important human pathogen group B Streptococcus (GBS). We now report global gene expression studies in GBS strains 2603V/R and 515 and their isogenic csrR and csrS mutants. Together wit

  2. A Novel CSR-Based Sparse Matrix-Vector Multiplication on GPUs

    Directory of Open Access Journals (Sweden)

    Guixia He

    2016-01-01

    Full Text Available Sparse matrix-vector multiplication (SpMV is an important operation in scientific computations. Compressed sparse row (CSR is the most frequently used format to store sparse matrices. However, CSR-based SpMVs on graphic processing units (GPUs, for example, CSR-scalar and CSR-vector, usually have poor performance due to irregular memory access patterns. This motivates us to propose a perfect CSR-based SpMV on the GPU that is called PCSR. PCSR involves two kernels and accesses CSR arrays in a fully coalesced manner by introducing a middle array, which greatly alleviates the deficiencies of CSR-scalar (rare coalescing and CSR-vector (partial coalescing. Test results on a single C2050 GPU show that PCSR fully outperforms CSR-scalar, CSR-vector, and CSRMV and HYBMV in the vendor-tuned CUSPARSE library and is comparable with a most recently proposed CSR-based algorithm, CSR-Adaptive. Furthermore, we extend PCSR on a single GPU to multiple GPUs. Experimental results on four C2050 GPUs show that no matter whether the communication between GPUs is considered or not PCSR on multiple GPUs achieves good performance and has high parallel efficiency.

  3. Promoting Reading Comprehension, Content Learning, and English Acquisition through Collaborative Strategic Reading (CSR).

    Science.gov (United States)

    Klingner, Janette K.; Vaughn, Sharon

    1999-01-01

    Describes procedures for teaching Collaborative Strategic Reading (CSR), in which students of mixed reading and achievement levels work in small, cooperative groups to assist one another in applying reading strategies to facilitate their comprehension of content-area text. Discusses whole-class instruction of CSR strategies, implementing CSR in…

  4. The bad, the ugly and the good: new challenges for CSR communication

    NARCIS (Netherlands)

    W.J.L. Elving; U. Golob; K. Podnar; A. Ellerup-Nielsen; C. Thomson

    2015-01-01

    Purpose - This editorial is an introduction to the special issue on CSR Communication attached to the second CSR Communication Conference held in Aarhus (Denmark) in September 2013. The purpose of this paper is to critically evaluate the role of CSR communication and the development of theory and pr

  5. How Does It Fit? Exploring the Congruence Between Organizations and Their Corporate Social Responsibility (CSR) Activities

    NARCIS (Netherlands)

    Jong, de Menno D.T.; Meer, van der Mark

    2015-01-01

    Several studies have focused on the effects of corporate social responsibility (CSR) fit on external stakeholders’ evaluations of CSR activities, attitudes towards companies or brands, and behaviors. The results so far have been contradictory. A possible reason may be that the concept of CSR fit is

  6. The Csr system regulates genome-wide mRNA stability and transcription and thus gene expression in Escherichia coli

    Science.gov (United States)

    Esquerré, Thomas; Bouvier, Marie; Turlan, Catherine; Carpousis, Agamemnon J.; Girbal, Laurence; Cocaign-Bousquet, Muriel

    2016-01-01

    Bacterial adaptation requires large-scale regulation of gene expression. We have performed a genome-wide analysis of the Csr system, which regulates many important cellular functions. The Csr system is involved in post-transcriptional regulation, but a role in transcriptional regulation has also been suggested. Two proteins, an RNA-binding protein CsrA and an atypical signaling protein CsrD, participate in the Csr system. Genome-wide transcript stabilities and levels were compared in wildtype E. coli (MG1655) and isogenic mutant strains deficient in CsrA or CsrD activity demonstrating for the first time that CsrA and CsrD are global negative and positive regulators of transcription, respectively. The role of CsrA in transcription regulation may be indirect due to the 4.6-fold increase in csrD mRNA concentration in the CsrA deficient strain. Transcriptional action of CsrA and CsrD on a few genes was validated by transcriptional fusions. In addition to an effect on transcription, CsrA stabilizes thousands of mRNAs. This is the first demonstration that CsrA is a global positive regulator of mRNA stability. For one hundred genes, we predict that direct control of mRNA stability by CsrA might contribute to metabolic adaptation by regulating expression of genes involved in carbon metabolism and transport independently of transcriptional regulation. PMID:27112822

  7. The Csr system regulates genome-wide mRNA stability and transcription and thus gene expression in Escherichia coli.

    Science.gov (United States)

    Esquerré, Thomas; Bouvier, Marie; Turlan, Catherine; Carpousis, Agamemnon J; Girbal, Laurence; Cocaign-Bousquet, Muriel

    2016-01-01

    Bacterial adaptation requires large-scale regulation of gene expression. We have performed a genome-wide analysis of the Csr system, which regulates many important cellular functions. The Csr system is involved in post-transcriptional regulation, but a role in transcriptional regulation has also been suggested. Two proteins, an RNA-binding protein CsrA and an atypical signaling protein CsrD, participate in the Csr system. Genome-wide transcript stabilities and levels were compared in wildtype E. coli (MG1655) and isogenic mutant strains deficient in CsrA or CsrD activity demonstrating for the first time that CsrA and CsrD are global negative and positive regulators of transcription, respectively. The role of CsrA in transcription regulation may be indirect due to the 4.6-fold increase in csrD mRNA concentration in the CsrA deficient strain. Transcriptional action of CsrA and CsrD on a few genes was validated by transcriptional fusions. In addition to an effect on transcription, CsrA stabilizes thousands of mRNAs. This is the first demonstration that CsrA is a global positive regulator of mRNA stability. For one hundred genes, we predict that direct control of mRNA stability by CsrA might contribute to metabolic adaptation by regulating expression of genes involved in carbon metabolism and transport independently of transcriptional regulation. PMID:27112822

  8. The single-mode CSR instability for a bunched beam

    CERN Document Server

    Heifets, S

    2003-01-01

    The coherent synchrotron radiation (CSR) instability at the shielding threshold may be driven by a single synchronous mode excited by the beam in the beam pipe. The instability in this case has been analyzed [1] in the coasting beam approximation neglecting synchrotron motion. The later becomes important at large time intervals in storage rings where it substantially affects the beam dynamics. The single-mode CSR instability of a bunched beam with the synchrotron motion taken into account is described in this paper both in linear and nonlinear regimes. Analysis is relevant to other instabilities where the interaction is dominated by a single mode.

  9. Vplyv CSR na image značky

    OpenAIRE

    Mičáková, Veronika

    2010-01-01

    The main aim of this diploma thesis is to discover an evidence of CSR influence upon brand image. More precisely, I will attempt to explore the impact of L'Oréal corporate social responsibility on L'Oréal Paris brand image. The concept of CSR, the center of the brand and brand image are described in the introduction. For better understanding, there are also practical examples provided. Chapter number three creates a fluent connecting link between theoretical and practical part, briefly charac...

  10. Theory and Simulation of CSR Microbunching in Bunch Compressors

    International Nuclear Information System (INIS)

    CSR microbunching instability in bunch compressors is studied both analytically and numerically. The iterative solutions of the integral equation for the instability provide approximate expressions of CSR microbunching due to initial density and energy modulation, and can be applied to a series of bending systems consisting of multiple compressor chicanes and transport lines. Two similar but independent simulation methods are developed and are compared to each other as well as with theory. We determine the total gain in density modulation for all bend systems of the Linac Coherent Light Source and discuss initial conditions that start the unstable process

  11. Nonlinear Regime of a Single-mode CSR Instability

    International Nuclear Information System (INIS)

    Close to the shielding threshold of synchrotron radiation in a toroidal waveguide the coherent synchrotron radiation (CSR) instability may be driven by a single synchronous mode. The linear analysis of the problem is presented elsewhere. In this paper we study a nonlinear regime of the single-mode CSR instability. We show that in the nonlinear regime the instability is described by a system of equations which, after a proper scaling, coincides with the 1D FEL instability theory. We present numeric and analytic analysis of the non-linear regime for the time interval large compared with the damping time taking into account radiation damping and diffusion due to the quantum fluctuations

  12. The single-mode CSR instability for a bunched beam

    International Nuclear Information System (INIS)

    The coherent synchrotron radiation (CSR) instability at the shielding threshold may be driven by a single synchronous mode excited by the beam in the beam pipe. The instability in this case has been analyzed [1] in the coasting beam approximation neglecting synchrotron motion. The later becomes important at large time intervals in storage rings where it substantially affects the beam dynamics. The single-mode CSR instability of a bunched beam with the synchrotron motion taken into account is described in this paper both in linear and nonlinear regimes. Analysis is relevant to other instabilities where the interaction is dominated by a single mode

  13. Theory and simulation of CSR microbunching in bunch compressors

    International Nuclear Information System (INIS)

    CSR microbunching instability in bunch compressors is studied both analytically and numerically. The iterative solutions of the integral equation for the instability provide approximate expressions of CSR microbunching due to initial density and energy modulation, and can be applied to a series of bending systems consisting of multiple compressor chicanes and transport lines. Two similar but independent simulation methods are developed and are compared to each other as well as with theory. They determine the total gain in density modulation for all bend systems of the Linac Coherent Light Source and discuss initial conditions that start the unstable process

  14. Impact on the magnetic compressor due to CSR

    Institute of Scientific and Technical Information of China (English)

    LIU Chu-Yu; WANG Fang; WANG Er-Dong; QUAN Sheng-Wen; HAO Jian-Kui; LU Xiang-Yang; ZHANG Bao-Cheng; ZHAO Kui

    2008-01-01

    When an electron bunch is compressed in a chicane compressor,the CSR (coherent synchrotron radiation) will induce energy redistribution along the bunch.Such energy redistribution will affect the longitudinal emittance as a direct consequence.It will also excite betatron oscillation due to the chromatic transfer functions,and hence a transverse emittance change.So,it is indispensable for us to find a way to alleviate the CSR-cansed emittance dilution and the bad result of chicane compressor in PKU-FEL.

  15. The Collectivity in Csr 129Xe+129Xe Collisions

    Science.gov (United States)

    Xie, Fei; Wu, Kejun; Liu, Feng

    The Heavy Ion Research Facility in Lanzhou (HIRFL) - Cooler Storage Ring (CSR), which can gather few hundreds MeV/nucleon for heavy ion beam energy in the external-target experiments, could make a significant contribution in studying the property of dense matter. By using a Relativistic Transport Model(ART1.0), we study the collectivity of identified hadrons in 129Xe+129Xe collisions in CSR energy regions. Our investigation indicates that the anisotropic flow reaches its extremum around 500 MeV/nucleon of beam energy. The system size and EOS dependence on anisotropic flow show that directed flow is very sensitive to the equation of state.

  16. LACK OF EXPERTS AS AN IDEAL INTRODUCTION TO CSR

    OpenAIRE

    Simone Matthaei

    2013-01-01

    The Federal Ministry of Labour and Social Affairs (Bundesministerium für Arbeit und Soziales, BMA) is supporting 73 projects in Germany using European Union (EU) funds in the amount of € 26 million. By providing the subsidies, the European Commission and the German Federal Government are hoping to implement Corporate Social Responsibility (CSR) among German small and medium-sized businesses (SMBs). The project run by Bonn-Rhein-Sieg University is one of these CSR projects. It is aimed at prov...

  17. CSR and Company Reputation - Case study of Nike

    OpenAIRE

    Valjakka, Mira

    2013-01-01

    During the 21st century, we have seen an enormous increase in the popularity of CSR, in corporate level as well as in public media. Society’s consciousness on the effects of individual behaviour has risen with increased awareness on environmental and societal issues such as global warming and human rights. Corporate catastrophes, such as BP oil spill in Gulf of Mexico in 20101, which was the biggest oil spill in history of United States, has woken companies to protect their CSR reputation. ...

  18. PET-CT in Determining the Radioembolization Dose Delivered to Patients With Liver Metastasis, Primary Liver Cancer, or Biliary Cancer

    Science.gov (United States)

    2016-03-01

    Adult Primary Hepatocellular Carcinoma; Advanced Adult Primary Liver Cancer; Metastatic Extrahepatic Bile Duct Cancer; Recurrent Adult Primary Liver Cancer; Recurrent Extrahepatic Bile Duct Cancer; Stage D Adult Primary Liver Cancer (BCLC); Unspecified Adult Solid Tumor, Protocol Specific

  19. Beating and insulting children as a risk for adult cancer, cardiac disease and asthma.

    Science.gov (United States)

    Hyland, Michael E; Alkhalaf, Ahmed M; Whalley, Ben

    2013-12-01

    The use of physical punishment for children is associated with poor psychological and behavioral outcomes, but the causal pathway is controversial, and the effects on later physical health unknown. We conducted a cross-sectional survey of asthma, cancer, and cardiac patients (150 in each category, 75 male) recruited from outpatient clinics and 250 healthy controls (125 male). All participants were 40-60 years old and citizens of Saudi Arabia, where the use of beating and insults is an acceptable parenting style. Demographic data and recalled frequency of beatings and insults as a child were assessed on an 8-point scale. Beating and insults were highly correlated (ρ = 0.846). Propensity score matching was used to control for demographic differences between the disease and healthy groups. After controlling for differences, more frequent beating (once or more per month) and insults were associated with a significantly increased risk for cancer (RR = 1.7), cardiac disease (RR = 1.3) and asthma (RR = 1.6), with evidence of increased risk for cancer and asthma with beating frequency of once every 6 months or more. Our results show that a threatening parenting style of beating and insults is associated with increased risk for somatic disease, possibly because this form of parenting induces stress. Our findings are consistent with previous research showing that child abuse and other early life stressors adversely affect adult somatic health, but provide evidence that the pathogenic effects occur also with chronic minor stress. A stress-inducing parenting style, even when normative, has long term adverse health consequences. PMID:23054177

  20. Young Adult Cancer Survivors' Experience with Cancer Treatment and Follow-Up Care and Perceptions of Barriers to Engaging in Recommended Care.

    Science.gov (United States)

    Berg, Carla J; Stratton, Erin; Esiashvili, Natia; Mertens, Ann

    2016-09-01

    We examined correlates of low engagement in the healthcare system, experiences with survivorship care, barriers to follow-up care, and potential resources for promoting follow-up care among young adult survivors of childhood cancers. We conducted a mixed-method study involving surveys of 106 survivors of childhood cancer aged 18-34 recruited from a university-affiliated children's hospital and an NCI-designated cancer center in the Southeastern USA. Phone-based semistructured interviews were then conducted in a subset of 26. Assessments included health factors, psychosocial factors, healthcare system interaction, and interest in resources to promote engagement in healthcare. Survey participants were on average 22.14 (SD = 3.16) years old, 50.0 % female, and 77.4 % White. Overall, 46.0 % had attended survivorship clinic, 47.2 % reported receiving a treatment summary, 68.9 % had a primary care provider, and 17.0 % reported no interaction with healthcare in the past 2 years. Correlates of less than annual healthcare provider visits included being older (p = 0.003), being male (p adult care. Participants highlighted the need for educational and psychosocial resources, particularly technology-based resources. Multilevel interventions are needed to increase engagement in survivorship care among young adult cancer survivors. Technology-based resources addressing social support and mental well-being are intervention possibilities. PMID:25948413

  1. Cancer of Unknown Primary in Adolescents and Young Adults: Clinicopathological Features, Prognostic Factors and Survival Outcomes.

    Directory of Open Access Journals (Sweden)

    Kanwal Raghav

    Full Text Available Cancer in adolescents and young adults (AYAs (15-39 years is increasingly recognized as a distinct clinical and biological entity. Cancer of unknown primary (CUP, a disease traditionally presenting in older adults with a median age of 65 years, poses several challenges when diagnosed in AYA patients. This study describes clinicopathological features, outcomes and challenges in caring for AYA-CUP patients.A retrospective review of 47 AYAs diagnosed with CUP at MD Anderson Cancer Center (6/2006-6/2013 was performed. Patients with favorable CUP subsets treated as per site-specific recommendations were excluded. Demographics, imaging, pathology and treatment data was collected using a prospectively maintained CUP database. Kaplan-Meier product limit method and log-rank test were used to estimate and compare overall survival. The cox-proportional model was used for multivariate analyses.Median age was 35 years (range 19-39. All patients underwent comprehensive workup. Adenocarcinoma was the predominant histology (70%. A median of 9 immunostains (range 2-29 were performed. The most common putative primary was biliary tract based on clinicopathological parameters as well as gene profiling. Patients presented with a median of 2 metastatic sites [lymph node (60%, lung (47%, liver (38% and bone (34%]. Most commonly used systemic chemotherapies included gemcitabine, fluorouracil, taxanes and platinum agents. Median overall survival for the entire cohort was 10.0 (95% confidence interval (CI: 6.7-15.4 months. On multivariate analyses, elevated lactate dehydrogenase (Hazard ratio (HR 3.66; 95%CI 1.52-8.82; P = 0.004, ≥3 metastatic sites (HR 5.34; 95%CI 1.19-23.9; P = 0.029, and tissue of origin not tested (HR 3.4; 95%CI 1.44-8.06; P = 0.005 were associated with poor overall survival. Culine's CUP prognostic model (lactate dehydrogenase, performance status, liver metastases was validated in this cohort (median overall survival: good-risk 25.2 months vs

  2. Considering GH replacement for GH-deficient adults with a previous history of cancer: a conundrum for the clinician.

    Science.gov (United States)

    Yuen, Kevin C J; Heaney, Anthony P; Popovic, Vera

    2016-05-01

    Previous studies have shown that GH and IGF-I may enhance tumorigenesis, metastasis, and cell proliferation in humans and animals. Evidence supporting this notion is derived from animal model studies, epidemiological studies, experience from patients with acromegaly, molecular therapeutic manipulation of GH and IGF-I actions, and individuals with GH receptor and congenital IGF-I deficiencies. Prior exposure to radiation therapy, aging, family history of cancer, and individual susceptibility may also contribute to increase this risk. Therefore, the use of GH replacement in patients with a history of cancer raises hypothetical safety concerns for patients, caregivers, and providers. Studies of GH therapy in GH-deficient adults with hypopituitarism and childhood cancer survivors have not convincingly demonstrated an increased cancer risk. Conversely, the risk of occurrence of a second neoplasm (SN) in childhood cancer survivors may be increased, with meningiomas being the most common tumor; however, this risk appears to decline over time. In light of these findings, if GH replacement is to be considered in patients with a previous history of cancer, we propose this consideration to be based on each individual circumstance and that such therapy should only be initiated at least 2 years after cancer remission is achieved with the understanding that in some patients (particularly those with childhood cancers), GH may potentially increase the risk of SNs. In addition, close surveillance should be undertaken working closely with the patient's oncologist. More long-term data are thus needed to determine if GH replacement in GH-deficient adults with a history of cancer is associated with the development of de novo tumors and tumor recurrence. PMID:26732039

  3. CSR: Bridging business and development for sustainability : a case study of CSR implementation at coffee houses as enabler for sustainable development and livelihood among small-scale produsers

    OpenAIRE

    Melbye, Janne Gillgren

    2010-01-01

    A prerequisite for achievement of sustainable development is economical growth (NorwegianGovernment, 2008-2009). Today an increasing number of corporations in the Western world implement the concept of Corporate Social Responsibility (CSR) (NorwegianEmbassyMexico, 2010a; NorwegianGovernment, 2008-2009). Accountability theories suggests that CSR initiatives increases transparency and accountability of a company, which again increases its legitimacy (Bendell, 2000; Utting, 2005). CSR is makes ―...

  4. CSR v ČR – chtějí firmy celonárodní systém koordinace CSR?

    OpenAIRE

    Skřivan, Lukáš

    2014-01-01

    This bachelor thesis connects the concept of corporate social responsibility (CSR) with sustainable development. In general, it shows the theoretical essentials of CSR area. Based on own research among companies in the Czech republic, the thesis analyzes, in specific factors, what expectations companies had of implementing the CSR to business strategy. These expectations are then, by firms, compared to evaluations of positives in said specific factors. The results show, that expectations are ...

  5. CSR activities within service corporations : A case study about how four legal jurists and their service corporation conduct CSR activities with primary focus on SME law firms.

    OpenAIRE

    Kornmann, Jan; Adolfsson, Marcus

    2010-01-01

    Purpose: The purpose of this thesis is to interview four legal jurists in order to explore how they conduct CSR activities within their service corpora-tion, with primary focus on SME law firms. Background: A current issue to address concerning the conduct of business these days is CSR activities. Although, the previous research concerning CSR activities and the service sector is limited. Theoretical Framework: The theoretical framework is divided into four parts; a general part concerning th...

  6. Reflexive regulation of CSR to promote sustainablility:understanding EU public-private regulation on CSR thourgh the case of human rights

    OpenAIRE

    Buhmann, Karin

    2010-01-01

    This article discusses Corporate Social Responsibility (CSR) from the perspective of governmental regulation as a measure to promote public policy interests through public-private regulation intended to influence firms’ self-regulation. Presenting a ‘government case’ for CSR, the connection between climate change and environmental sustainability, and social, economic and other human rights lend human rights as part of CSR a potential for meeting some environmental and climate concerns and han...

  7. Variation in the Group B Streptococcus CsrRS Regulon and Effects on Pathogenicity▿ †

    OpenAIRE

    Jiang, Sheng-Mei; Ishmael, Nadeeza; Hotopp, Julie Dunning; Puliti, Manuela; Tissi, Luciana; Kumar, Nikhil; Cieslewicz, Michael J.; Tettelin, Hervé; Wessels, Michael R.

    2008-01-01

    CsrRS (or CovRS) is a two-component regulatory system that controls expression of multiple virulence factors in the important human pathogen group B Streptococcus (GBS). We now report global gene expression studies in GBS strains 2603V/R and 515 and their isogenic csrR and csrS mutants. Together with data reported previously for strain NEM316, the results reveal a conserved 39-gene CsrRS regulon. In vitro phosphorylation-dependent binding of recombinant CsrR to promoter regions of both positi...

  8. Multinationals, CSR and partnerships in Central African conflict countries

    NARCIS (Netherlands)

    A. Kolk; F. Lenfant

    2013-01-01

    Attention has increased for the potential role of multinational enterprises (MNEs) in helping address conflict issues and/or furthering peace and reconciliation as part of their corporate social responsibility (CSR) policies. However, while existing literature emphasises the importance for MNEs to c

  9. Are CSR disclosures relevant for investors? Empirical evidence from Germany

    NARCIS (Netherlands)

    Verbeeten, F.H.M.; Gamerschlag, R.; Möller, K.

    2016-01-01

    Purpose – The purpose of this paper is to examine whether narrative corporate social responsibility (CSR) disclosures (the provision of textual information on companies’ environmental and social performance to external stakeholders) are associated with firm value in Germany. Design/methodology/appro

  10. Closing the Achievement Gap: Urban Schools. CSR Connection.

    Science.gov (United States)

    Porter, Kathleen; Soper, Stephanie

    This report reviews efforts to reform urban schools, focusing on initiatives in Tennessee and California as examples from which distric leaders may draw useful lessons. The report suggests that comprehensive school reform (CSR) offers promise to struggling urban schools by focusing on transforming the academic climate, school culture, and…

  11. Highly charged atomic physics at HIRFL-CSR

    International Nuclear Information System (INIS)

    HIRFL-CSR is a proposed electron cooling storage ring optimized to accelerate and store beams of highly charged heavy ions. Several possibilities for advanced atomic physics studies are discussed, such as studies of electron-ion, ion-atoms, photon-ion-electron interactions and high resolution spectroscopy

  12. Birthing histone mRNAs by CSR-1 section

    OpenAIRE

    Pasquinelli, Amy E.

    2012-01-01

    Histone pre-mRNAs undergo maturation through a mechanism distinct from all other RNA Pol II transcripts. In C. elegans, 3′-end processing of histone mRNAs depends on the RNAi pathway involving the Argonaute protein CSR-1.

  13. Opening the CSR Discourse for Critical Stakeholders in Social Media

    DEFF Research Database (Denmark)

    Etter, Michael

    This study examines how a contested fast food chain in the middle of on-going image transformation efforts opens the distorted discourse about CSR with a social media campaign and enables the interference of official corporate communication and stakeholder critique. The study examines how...

  14. AN INVESTIGATION OF CSR ORIENTATIONS AMONG GREEK UNIVERSITY STUDENTS

    OpenAIRE

    Robyn Walker; Charalambos Kanellopoulos; Maria Papanayiotou; Antonios Vitalis

    2003-01-01

    This paper presents the results of a survey of the corporate social responsibility (CSR) orientations of commerce students at the University of Piraeus. The study utilised the instrument developed by Aupperle (1982, cited in Aupperle, Carroll, & Hatfield, 1985) based on Carroll's (1979) social responsibility framework. Comparisons are made with the results of other surveys that have used the same method.

  15. Ownership Concentration and CSR Policy of European Multinational Enterprises

    NARCIS (Netherlands)

    Dam, Lammertjan; Scholtens, Bert

    2013-01-01

    This study investigates how ownership concentration in European multinational firms is associated with these firms' corporate social responsibility (CSR). We employ factor analysis on responsibility data from EIRiS and use a regression analysis. Using firm-level data for almost 700 European firms, w

  16. Association between adult otitis media and nasopharyngeal cancer: A nationwide population-based cohort study

    International Nuclear Information System (INIS)

    Purpose: To determine whether the diagnosis of otitis media (OM) in adults is associated with an increased risk for the subsequent development of nasopharyngeal cancer (NPC) using a nationwide population-based retrospective study. Methods and materials: We selected 13,513 adult patients that had been previously diagnosed with OM between 2000 and 2005 from the Taiwan Longitudinal Health Insurance Database 2000 as the study cohort, and randomly extracted the data of 135,130 participants matched by sex, age, and baseline year for the comparison cohort. The follow-up period was terminated upon developing NPC, withdrawal from the national health insurance system, or the end of 2009. Cumulative incidences and hazard ratios (HRs) of NPC development were determined. Results: The subsequent NPC incidence rates in the OM and comparison cohorts were 6.41 and 0.58 per 10 000 person-years, respectively (adjusted HR, 11.04; 95% CI, 7.68–5.87; P < 0.0001). The NPC risk for males was significantly higher than that for females (adjusted HR = 3.24; 95% CI, 2.16–4.85). In both female and male patients, the diagnosis of OM was associated with a significantly increased risk for NPC (adjusted HR, 11.91 vs. 10.78, respectively). Among the OM cohort, 62 participants were subsequently diagnosed with NPC, with 71% of them occurring within 1 year following the diagnosis of OM. However, even after 5-year follow-up, the OM cohort still displayed a higher risk for NPC (adjusted HR = 2.50). Stratified by the frequency of OM episodes, more than one episode per year had a significantly greater risk of developing NPC, compared with the comparison cohort (HR = 29.22; 95% CI, 20.19–42.27). Conclusion: We found that adult OM is a warning sign for the development of NPC in Taiwan, with approximately an 11-fold higher risk for adult OM patients. We recommend that OM patients undergo follow-up examinations for at least 5 years. To extrapolate our findings, further studies are warranted in other

  17. In Silico Identification and Experimental Characterization of Regulatory Elements Controlling the Expression of the Salmonella csrB and csrC Genes

    OpenAIRE

    Martínez, Luary C.; Martínez-Flores, Irma; Salgado, Heladia; Fernández-Mora, Marcos; Medina-Rivera, Alejandra; Puente, José L.; Collado-Vides, Julio; Bustamante, Víctor H.

    2014-01-01

    The small RNAs CsrB and CsrC of Salmonella indirectly control the expression of numerous genes encoding widespread cellular functions, including virulence. The expression of csrB and csrC genes, which are located in different chromosomal regions, is coordinated by positive transcriptional control mediated by the two-component regulatory system BarA/SirA. Here, we identified by computational analysis an 18-bp inverted repeat (IR) sequence located far upstream from the promoter of Salmonella en...

  18. SOCIAL PERFORMANCE ENHANCES FINANCIAL PERFORMANCE. BENEFITS FROM CSR

    Directory of Open Access Journals (Sweden)

    gazzola patrizia

    2012-07-01

    Full Text Available The research aims to show how Corporate Social Responsibility (CSR should not be considered a cost to bear as an economic social actor but an investment that will contribute to the competitiveness and growth of the firm. In the first part we consider capitalistic firm as systems for the creation of economic and financial value for their shareholders. We measure their performance by a system of monetary values. In the second part we do not limit our view to simply the shareholders, but we consider, instead a vast group of stakeholders because it is important not only to make profits, but also how companies make them . In these years characterized by the financial crisis, where many big companies went bankrupt, more and more companies are speaking about ethics and CSR. For a firm, acting socially responsible, means for example having fair compensations, promoting transparency and the respect of employees, neutralizing conflicts of interest, as well as taking care of the environment. CSR is today a topic for discussion not only for business people but also for politicians, media, researchers, NGOs and consumers. Growing awareness of CSR is evident in the growth of voluntary codes of corporate conduct, in the growth of companies that are using self-reporting on social and environmental practices, and in increasingly social and ethical investment funds. The public and governments of the world have been steadily increasing pressure on corporations to increase their CSR. Recently the European Commission has put forward a new, simpler definition of corporate social responsibility as “the responsibility of enterprises for their impacts on society” (European Commission 25/10/2011. Companies have realized that to increase their market share or keep their market share, they must adopt CSR, but the synergy between social performance and financial performance is not automatic; rather it is the result of efforts that combine managerial

  19. The global regulatory system Csr senses glucose through the phosphoenolpyruvate: carbohydrate phosphotransferase system.

    Science.gov (United States)

    Pérez-Morales, Deyanira; Bustamante, Víctor H

    2016-02-01

    A novel connection between two regulatory systems controlling crucial biological processes in bacteria, the carbon storage regulator (Csr) system and the glucose-specific phosphotransferase system (PTS), is reported by Leng et al. in this issue. This involves the interaction of unphosphorylated EIIA(Glc), a component of the glucose-specific PTS, with the CsrD protein, which accelerates the decay of the CsrB and CsrC small RNAs via RNase E in Escherichia coli. As unphosphorylated EIIA(G) (lc) is generated in the presence of glucose, the PTS thus acts as a sensor of glucose for the Csr system. Interestingly, another pathway can operate for communication between the Csr system and the glucose-specific PTS. The absence of glucose generates phosphorylated EIIA(Glc) , which activates the enzyme adenylate cyclase to produce cyclic adenosine monophosphate (cAMP) that, in turn, binds to the regulator cAMP receptor protein (CRP). Leng et al. show that the complex cAMP-CRP modestly reduces CsrB decay independently of CsrD. On the other hand, a previous study indicates that the complex cAMP-CRP positively regulates the transcription of CsrB and CsrC in Salmonella enterica. Therefore, EIIA(G) (lc) could work as a molecular switch that regulates the activity of the Csr system, in response to its phosphorylation state determined by the presence or absence of glucose, in order to control gene expression. PMID:26593223

  20. The Integration of Corporate Social Responsibility (CSR) Initiatives into Business Activities

    DEFF Research Database (Denmark)

    Knudsen, Jette Steen

    While proponents of Corporate Social Responsibility (CSR) have suggested that CSR initiatives should be integrated into mainstream business activities as ‘strategic CSR’ or ‘shared value’, research is lacking that explores how CSR initiatives are integrated in companies. This article compares CSR...... initiatives to human resource management (HRM) initiatives, which have a longer tradition of being integrated into company strategy. The focus is on gender diversity and CSR initiatives in a US multinational corporation (MNC). The MNC sees gender diversity as an integral part of business activities....... In contrast, the MNC lacks a clear justification for the much broader CSR agenda, CSR activities seem not to reflect an overall set of values or purpose, integration into business activities is unclear, and targets are lacking....

  1. Life Satisfaction and Psychological Well-Being of Older Adults With Cancer Experience: The Role of Optimism and Volunteering.

    Science.gov (United States)

    Heo, Jinmoo; Chun, Sanghee; Lee, Sunwoo; Kim, Junhyoung

    2016-09-01

    Promoting health and well-being among individuals of advancing age is a significant issue due to increased incidence of cancer among older adults. This study demonstrates the benefits of expecting positive outcomes and participating in volunteer activities among older adults with cancer. We used a nationally representative sample of 2,670 individuals who have experienced cancer from the 2008 wave of the Health and Retirement Study. We constructed a structural equation model to explore the associations of optimism, volunteerism, life satisfaction, and psychological well-being. The level of optimism was a significant predictor of volunteerism, which in turn affected life satisfaction and psychological well-being. The level of engagement in volunteer activities was found to have significant path coefficients toward both life satisfaction and psychological well-being. Our study provides evidence that older adults who have experienced cancer and maintained a positive outlook on their lives and engaged in personally meaningful activities tended to experience psychological well-being and life satisfaction.

  2. The Effect of Transition Clinics on Knowledge of Diagnosis and Perception of Risk in Young Adult Survivors of Childhood Cancer

    Science.gov (United States)

    Ganju, Rohit G.; Nanda, Ronica H.; Esiashvili, Natia; Switchenko, Jeffrey M.; Wasilewski-Masker, Karen; Marchak, Jordan G.

    2016-01-01

    Background Improved treatment for pediatric cancers has ensured an evergrowing population of patients surviving into adulthood. The current study evaluated the impact of previous engagement in survivor care on patient knowledge and awareness of health risks as young adults. Procedure Young adult survivors of childhood cancers (N = 93, M age = 23.63 y) were recruited during their annual survivor clinic visit. Participants completed self-reported measures of demographics, treatment knowledge, perception of future health risks, participation in previous survivor care, and neurocognitive functioning. Results In total, 82% of patients (N = 76/93) reported previously participating in survivorship care. These patients were more likely to have knowledge of their radiation treatment (P = 0.034) and more likely to recognize risk for future health effects from their treatment (P = 0.019). Income between $10,000 and $24,999 (odds ratio = 0.168; 95% confidence interval, 0.046–0.616; P = 0.031) was associated with decreased patient knowledge regarding diagnosis. Male sex (odds ratio = 0.324; 95% confidence interval, 0.135–0.777; P = 0.012) was associated with less knowledge of future health risks. Patients with self-reported difficulties on the CCSS-NCQ were more likely to regard their cancer treatment as a future health risk. Conclusion Participation in survivor care plays an important role in imparting information to young adult survivors of pediatric cancer regarding their disease history and risk for future health problems. PMID:26925717

  3. CSR Fields: Direct Numerical Solution of the Maxwell's Equation

    International Nuclear Information System (INIS)

    We discuss the properties of the coherent electromagnetic fields of a very short, ultra-relativistic bunch in a rectangular vacuum chamber inside a bending magnet. The analysis is based on the results of a direct numerical solution of Maxwell's equations together with Newton's equations. We use a new dispersion-free time-domain algorithm which employs a more efficient use of finite element mesh techniques and hence produces self-consistent and stable solutions for very short bunches. We investigate the fine structure of the CSR fields including coherent edge radiation. This approach should be useful in the study of existing and future concepts of particle accelerators and ultrafast coherent light sources. The coherent synchrotron radiation (CSR) fields have a strong action on the beam dynamics of very short bunches, which are moving in the bends of all kinds of magnetic elements. They are responsible for additional energy loss and energy spread; micro bunching and beam emittance growth. These fields may bound the efficiency of damping rings, electron-positron colliders and ultrafast coherent light sources, where high peak currents and very short bunches are envisioned. This is relevant to most high-brightness beam applications. On the other hand these fields together with transition radiation fields can be used for beam diagnostics or even as a powerful resource of THz radiation. A history of the study of CSR and a good collection of references can be found in (1). Electromagnetic theory suggests several methods on how to calculate CSR fields. The most popular method is to use Lienard-Wiechert potentials. Other approach is to solve numerically the approximate equations, which are a Schrodinger type equation. These numerical methods are described in (2). We suggest that a direct solution of Maxwell's equations together with Newton's equations can describe the detailed structure of the CSR fields (3).

  4. Intake and Biomarkers of Folate and Risk of Cancer Morbidity in Older Adults, NHANES 1999-2002 with Medicare Linkage.

    Directory of Open Access Journals (Sweden)

    Jing Hu

    Full Text Available After the 1998 mandatory folic acid fortification of enriched cereal-grain products in the U.S., safety concerns were raised that excess consumption of folic acid and high blood folate biomarkers detected in adults may increase the risk of certain types of cancer.Baseline data from about 1400 participants in the National Health and Nutrition Examination Survey (NHANES 1999-2002, aged ≥ 57 years were linked to Medicare and mortality files through December 31, 2007. Using cox proportional hazards regression models, we assessed associations between dietary folate equivalents, folate biomarkers, the presence of unmetabolized folic acid and, overall cancer incidence.With 8,114 person-years of follow-up (median follow-up, 6.3 years, about 125 cancer cases were identified. After adjusting for confounders, the hazard ratios of the highest quartile versus the second quartile of RBC folate and dietary folate equivalents were 0.54 (95% CI: 0.31-0.93 and 0.54 (95% CI: 0.30-0.95, respectively. Additionally, serum and RBC folate as continuous variables were inversely and significantly associated with cancer incidence (p<0.01. No significant associations were observed between the presence of unmetabolized folic acid, intake of naturally-occurring food folate or folic acid separately, and cancer incidence.High total folate intake and biomarkers in older adults appear to be protective against cancer in post-folic acid fortification years. This study does not show a negative impact of current level of folic acid fortification on cancer risk. As this is one of the few studies to examine the association between unmetabolized folic acid and cancer outcome, a study including a larger nationwide representative sample of the U.S. population is needed.

  5. Male reproductive health after childhood, adolescent, and young adult cancers: a report from the Children's Oncology Group.

    Science.gov (United States)

    Kenney, Lisa B; Cohen, Laurie E; Shnorhavorian, Margarett; Metzger, Monika L; Lockart, Barbara; Hijiya, Nobuko; Duffey-Lind, Eileen; Constine, Louis; Green, Daniel; Meacham, Lillian

    2012-09-20

    The majority of children, adolescents, and young adults diagnosed with cancer will become long-term survivors. Although cancer therapy is associated with many adverse effects, one of the primary concerns of young male cancer survivors is reproductive health. Future fertility is often the focus of concern; however, it must be recognized that all aspects of male health, including pubertal development, testosterone production, and sexual function, can be impaired by cancer therapy. Although pretreatment strategies to preserve reproductive health have been beneficial to some male patients, many survivors remain at risk for long-term reproductive complications. Understanding risk factors and monitoring the reproductive health of young male survivors are important aspects of follow-up care. The Children's Oncology Group Long-Term Follow-Up Guidelines for Survivors of Childhood, Adolescent, and Young Adult Cancer (COG-LTFU Guidelines) were created by the COG to provide recommendations for follow-up care of survivors at risk for long-term complications. The male health task force of the COG-LTFU Guidelines, composed of pediatric oncologists, endocrinologists, nurse practitioners, a urologist, and a radiation oncologist, is responsible for updating the COG-LTFU Guidelines every 2 years based on literature review and expert consensus. This review summarizes current task force recommendations for the assessment and management of male reproductive complications after treatment for childhood, adolescent, and young adult cancers. Issues related to male health that are being investigated, but currently not included in the COG-LTFU Guidelines, are also discussed. Ongoing investigation will inform future COG-LTFU Guideline recommendations for follow-up care to improve health and quality of life for male survivors.

  6. MODEL CORPORATE SOCIAL RESPONSIBILITY (CSR) PERUSAHAAN TAMBANG BATUBARA DI KABUPATEN LAHAT TERHADAP PEMBERDAYAAN MASYARAKAT BERBASIS KEARIFAN LOKAL

    OpenAIRE

    Antonius Suhadi; AR Febrian; Sri Turatmiyah

    2014-01-01

    Corporate Social Responsibility (CSR) is a corporate responsibility. The research intends to inves-tigate how CSR program is implemented, the role of local administrative, and CSR alternative model on the coal mining company in Lahat District. This normative and empiric research is aimed at finding out the implementation of local government role, and to find out the alternative model of CSR. The CSR implementation of PT BA and PT BAU as a mining company in the cooperation program includes ar...

  7. The Csr system regulates genome-wide mRNA stability and transcription and thus gene expression in Escherichia coli

    OpenAIRE

    Thomas Esquerré; Marie Bouvier; Catherine Turlan; Carpousis, Agamemnon J.; Laurence Girbal; Muriel Cocaign-Bousquet

    2016-01-01

    Bacterial adaptation requires large-scale regulation of gene expression. We have performed a genome-wide analysis of the Csr system, which regulates many important cellular functions. The Csr system is involved in post-transcriptional regulation, but a role in transcriptional regulation has also been suggested. Two proteins, an RNA-binding protein CsrA and an atypical signaling protein CsrD, participate in the Csr system. Genome-wide transcript stabilities and levels were compared in wildtype...

  8. Corporate Social Responsibility:A framework for analysing CSR heterogeneity through the case of Indonesian Palm Oil

    OpenAIRE

    Tanaya, Jimmy

    2013-01-01

    Corporate Social Responsibility (CSR) represents a recent manifestation of the shifting of Role of Business in Society (RBiS). This thesis aims to study the development of and negotiation of various RBiS among various governance actors as manifested in CSR practices. In so doing, it reveals the heterogeneity of CSR practices over time as a contrast to the rigid and simplistic delineation of CSR practices; the institutionalisation of CSR into business strategy that so far has been perceived as...

  9. CSR and CSR Reporting: Reporting as a way to create Socially Responsible Business

    Directory of Open Access Journals (Sweden)

    Fabio Andrés Bonilla Sanabria

    2011-12-01

    Full Text Available Admitting the theory of a company being a set of multiple interests, the first part of this article intends to give an overview of the Shareholder and Stockholders models in the Corporate Social Responsibility debate. The prevailing view in western Company Law (the cases of the UK and US are considered is that of the Shareholder Wealth Maximization model. For the author of the article, events such as the financial crisis showed that the financial conditions of companies giving its‘ extended effects should give way to calls for public accountability in company management. However there seems to be a deadlock given that the prevailing model favours shareholders.In this scenario the Reporting of Non-Financial Information is studied as a way to create socially responsible businesses. In addressing the reporting of non-financial information, the article provides a state of affairs regarding reporting and considers specific examples of disclosure of corporate information. The CSR battle has been transferred to the reporting of non-financial information but in this field there are many difficulties unresolved and challenges ahead.

  10. Treatment of adolescents and young adults (AYA) with cancer in a multidisciplinary setting: on the way to a highly specialized AYA unit.

    Science.gov (United States)

    Bernig, T; Jahn, F; Witkowsky, S; Huehn, R; Hentschel, A; Kegel, T; Schmoll, H-J; Körholz, D

    2013-11-01

    Further survival improvements of adolescents and young adults (AYA) with cancer are clearly affected by biological characteristics of the malignancies and age-specific needs. Multidisciplinary teams drawing expertice from both pediatric and adult cancer teams as well as clinical trials are required to meet the age specific needs of AYA patients with cancer. In 2011, the first AYA unit was established at the University Hospital Halle (Saale), where patients with newly-diagnosed cancer aged 15-25 are treated interdisciplinary by pediatric and adult oncologists. The enrollment into pediatric or adult clinical trials is controlled by age 18. Over the last 2 years, 19 AYA with cancer have been treated at the unit; and, in turn patients and their relatives reflected a high satisfaction with the offered novel health care approach. In the scope of the future Comprehensive Cancer Center at the University Hospital Halle (Saale), a complete ward is planned for all admitted AYA up to 25 years with cancer. The patients will be treated by a tumor-specialized multidisciplinary team of adult or pediatric oncologists and oncological surgeons. Therefore, we intend to establish a special teaching curriculum for physicians, nurses and psychosocial health care staff. Rather than age, cancer biology of a malignancy, surveillance data of late side effects as well as the age-specific needs of AYA patients will be crucial for best treatment options. PMID:24166088

  11. Young Adult Cancer Survivors’ Experience with Cancer Treatment and Follow-Up Care and Perceptions of Barriers to Engaging in Recommended Care

    Science.gov (United States)

    Stratton, Erin; Esiashvili, Natia; Mertens, Ann

    2016-01-01

    We examined correlates of low engagement in the healthcare system, experiences with survivorship care, barriers to follow-up care, and potential resources for promoting follow-up care among young adult survivors of childhood cancers. We conducted a mixed-method study involving surveys of 106 survivors of childhood cancer aged 18–34 recruited from a university-affiliated children’s hospital and an NCI-designated cancer center in the Southeastern USA. Phone-based semistructured interviews were then conducted in a subset of 26. Assessments included health factors, psychosocial factors, healthcare system interaction, and interest in resources to promote engagement in healthcare. Survey participants were on average 22.14(SD=3.16) years old, 50.0 % female, and 77.4 % White. Overall, 46.0 % had attended survivorship clinic, 47.2 % reported receiving a treatment summary, 68.9 % had a primary care provider, and 17.0 % reported no interaction with healthcare in the past 2 years. Correlates of less than annual healthcare provider visits included being older (p=0.003), being male (pneed for educational and psychosocial resources, particularly technology-based resources. Multilevel interventions are needed to increase engagement in survivor-ship care among young adult cancer survivors. Technology-based resources addressing social support and mental well-being are intervention possibilities. PMID:25948413

  12. CsrA Inhibits Translation Initiation of Escherichia coli hfq by Binding to a Single Site Overlapping the Shine-Dalgarno Sequence

    OpenAIRE

    Baker, Carol; Eory, Lel; Yakhnin, Helen; Mercante, Jeffrey; Romeo, Tony; Babitzke, Paul

    2007-01-01

    Csr (carbon storage regulation) of Escherichia coli is a global regulatory system that consists of CsrA, a homodimeric RNA binding protein, two noncoding small RNAs (sRNAs; CsrB and CsrC) that function as CsrA antagonists by sequestering this protein, and CsrD, a specificity factor that targets CsrB and CsrC for degradation by RNase E. CsrA inhibits translation initiation of glgC, cstA, and pgaA by binding to their leader transcripts and preventing ribosome binding. Translation inhibition is ...

  13. CsrA Inhibits Translation Initiation of Escherichia coli hfq by Binding to a Single Site Overlapping the Shine-Dalgarno Sequence▿

    OpenAIRE

    Baker, Carol; Eory, Lel; Yakhnin, Helen; Mercante, Jeffrey; Romeo, Tony; Babitzke, Paul

    2007-01-01

    Csr (carbon storage regulation) of Escherichia coli is a global regulatory system that consists of CsrA, a homodimeric RNA binding protein, two noncoding small RNAs (sRNAs; CsrB and CsrC) that function as CsrA antagonists by sequestering this protein, and CsrD, a specificity factor that targets CsrB and CsrC for degradation by RNase E. CsrA inhibits translation initiation of glgC, cstA, and pgaA by binding to their leader transcripts and preventing ribosome binding. Translation inhibition is ...

  14. Post-transcriptional regulation on a global scale: form and function of Csr/Rsm systems.

    Science.gov (United States)

    Romeo, Tony; Vakulskas, Christopher A; Babitzke, Paul

    2013-02-01

    Originally described as a repressor of gene expression in the stationary phase of growth, CsrA (RsmA) regulates primary and secondary metabolic pathways, biofilm formation, motility, virulence circuitry of pathogens, quorum sensing and stress response systems by binding to conserved sequences in its target mRNAs and altering their translation and/or turnover. While the binding of CsrA to RNA is understood at an atomic level, new mechanisms of gene activation and repression by this protein are still emerging. In the γ-proteobacteria, small non-coding RNAs (sRNAs) use molecular mimicry to sequester multiple CsrA dimers away from mRNA. In contrast, the FliW protein of Bacillus subtilis inhibits CsrA activity by binding to this protein, thereby establishing a checkpoint in flagellum morphogenesis. Turnover of CsrB and CsrC sRNAs in Escherichia coli requires a specificity protein of the GGDEF-EAL domain superfamily, CsrD, in addition to the housekeeping nucleases RNase E and PNPase. The Csr system of E. coli contains extensive autoregulatory circuitry, which governs the expression and activity of CsrA. Interaction of the Csr system with transcriptional regulatory networks results in a variety of complex response patterns. This minireview will highlight basic principles and new insights into the workings of these complex eubacterial regulatory systems. PMID:22672726

  15. Szanse i ograniczenia stosowania strategii CSR w polskich przedsiêbiorstwach/The Chances and the Limitation of Applying the CSR Strategy in Polish Enterprises

    OpenAIRE

    Codogni, Iwona

    2012-01-01

    The topic of the article is the perspectives of CSR in Polish companies. The article contains the definition of corporate social responsibility, the state and dynamics of ethical reporting and the factors that can influence the dynamics of CSR in Poland – both in a favourable and adverse way.

  16. A direct link between the global regulator PhoP and the Csr regulon in Y. pseudotuberculosis through the small regulatory RNA CsrC.

    Science.gov (United States)

    Nuss, Aaron M; Schuster, Franziska; Kathrin Heroven, Ann; Heine, Wiebke; Pisano, Fabio; Dersch, Petra

    2014-01-01

    In this study we investigated the influence of the global response regulator PhoP on the complex regulatory cascade controlling expression of early stage virulence genes of Yersinia pseudotuberculosis via the virulence regulator RovA. Our analysis revealed the following novel features: (1) PhoP activates expression of the CsrC RNA in Y. pseudotuberculosis, leading to activation of RovA synthesis through the CsrABC-RovM cascade, (2) activation of csrC transcription is direct and PhoP is shown to bind to two separate PhoP box-like sites, (3) PhoP-mediated activation results in transcription from two different promoters closely downstream of the PhoP binding sites, leading to two distinct CsrC RNAs, and (4) the stability of the CsrC RNAs differs significantly between the Y. pseudotuberculosis strains YPIII and IP32953 due to a 20 nucleotides insertion in CsrC(IP32953), which renders the transcript more susceptible to degradation. In summary, our study showed that PhoP-mediated influence on the regulatory cascade controlling the Csr system and RovA in Y. pseudotuberculosis varies within the species, suggesting that the Csr system is a focal point to readjust and adapt the genus to different hosts and reservoirs. PMID:24786463

  17. Is cancer a good way to die? A population-based survey among middle-aged and older adults in the United Kingdom

    OpenAIRE

    Vrinten, C.; Wardle, J.

    2016-01-01

    OBJECTIVES: Despite improved outcomes, cancer remains widely feared, often because of its association with a long and protracted death as opposed to the quick death that people associate with that other common cause of adult mortality: heart disease. Former editor-in-chief of the BMJ Richard Smith's view that 'cancer is the best way to die' therefore attracted much criticism. We examined middle-aged and older adults' agreement with this view and compared their attitudes towards dying from can...

  18. Using a stem cell-based signature to guide therapeutic selection in cancer.

    Science.gov (United States)

    Shats, Igor; Gatza, Michael L; Chang, Jeffrey T; Mori, Seiichi; Wang, Jialiang; Rich, Jeremy; Nevins, Joseph R

    2011-03-01

    Given the very substantial heterogeneity of most human cancers, it is likely that most cancer therapeutics will be active in only a small fraction of any population of patients. As such, the development of new therapeutics, coupled with methods to match a therapy with the individual patient, will be critical to achieving significant gains in disease outcome. One such opportunity is the use of expression signatures to identify key oncogenic phenotypes that can serve not only as biomarkers but also as a means of identifying therapeutic compounds that might specifically target these phenotypes. Given the potential importance of targeting tumors exhibiting a stem-like phenotype, we have developed an expression signature that reflects common biological aspects of various stem-like characteristics. The consensus stemness ranking (CSR) signature is upregulated in cancer stem cell-enriched samples at advanced tumor stages and is associated with poor prognosis in multiple cancer types. Using two independent computational approaches we utilized the CSR signature to identify clinically useful compounds that could target the CSR phenotype. In vitro assays confirmed selectivity of several predicted compounds including topoisomerase inhibitors and resveratrol towards breast cancer cell lines that exhibit a high-CSR phenotype. Importantly, the CSR signature could predict clinical response of breast cancer patients to a neoadjuvant regimen that included a CSR-specific agent. Collectively, these results suggest therapeutic opportunities to target the CSR phenotype in a relevant cohort of cancer patients. PMID:21169407

  19. Stakeholder Models for Social and Mobile Media CSR Projects

    DEFF Research Database (Denmark)

    Kampf, Constance Elizabeth

    2014-01-01

    businesses to reduce their ecological footprint in immediate and concrete ways, 2) define consumer point of purchase information sources about product goodness for health, community and the environment, or 3) to push their agendas for using corporate resources for aid purposes. These consumers organize...... to engage with business about Corporate Social Responsibility (CSR). Second, it discusses how this technology calls for an expansion of our understanding of how to interact with stakeholders. This includes moving from a communication-focused perspective to an engagement perspective, meaning that consumers...... now have the ability to engage with knowledge resources related to CSR made available through innovative uses of smartphone and social media technology. In these cases of consumer initiated sustainability-on-the go—the Good Guide, CarrotMob and Colalife— organizations founded by activist individuals...

  20. CSR Communication Strategies for Organizational Legitimacy in Social Media

    DEFF Research Database (Denmark)

    Colleoni, Elanor

    2013-01-01

    Purpose – Organization legitimacy is a general reflection of the relationship between an organization and its environment. By adopting an institutional approach and defining moral legitimacy as “a positive normative evaluation of the organization and its activities”, the goal of this paper...... is to investigate which corporate communication strategy adopted in online social media is more effective to create convergence between corporations' corporate social responsibility (CSR) agenda and stakeholders' social expectations, and thereby, to increase corporate legitimacy. Design/methodology/approach – Using...... the entire Twitter social graph, a network analysis was carried out to study the structural properties of the CSR community, such as the level of reciprocity, and advanced data mining techniques, i.e. topic and sentiment analysis, were carried out to investigate the communication dynamics. Findings...