WorldWideScience

Sample records for administration evidence supporting

  1. AIS, ADMINISTRATIVE INFORMATION SUPPORT

    CERN Multimedia

    AS-DB/AS-SU

    1999-01-01

    The AS-DB and AS-SU groups within the Administrative Support division now offer a central entry point to the computer based Information Services under their responsibilities: the AIS Web site at http://ais.cern.ch.It features comprehensive search and navigation facilities as well as an activity based business map to guide AIS users to the information they want. Users will be able to launch any AIS WEB application from its desktop.Enjoy a visit of the site, we value your feedback at ais.webmaster@cern.ch!AS-DB/AS-SU

  2. Case and Administrative Support Tools

    Data.gov (United States)

    U.S. Environmental Protection Agency — Case and Administrative Support Tools (CAST) is the secure portion of the Office of General Counsel (OGC) Dashboard business process automation tool used to help...

  3. Software Architecture Patterns for System Administration Support

    OpenAIRE

    Bijvank, Ronald; Wiersema, Wiebe; Köppe, Christian

    2013-01-01

    Many quality aspects of software systems are addressed in the existing literature on software architecture patterns. But the aspect of system administration seems to be a bit overlooked, even though it is an important aspect too. In this work we present three software architecture patterns that, when applied by software architects, support the work of system administrators: PROVIDE AN ADMINISTRATION API, SINGLE FILE LOCATION, and CENTRALIZED SYSTEM LOGGING. PROVIDE AN ADMINISTRATION API shoul...

  4. Marketing as support tool for public administration

    OpenAIRE

    Elena ENACHE; Morozan, Cristian

    2010-01-01

    The reality of public administration system in Romania shows that, in addition to normal and fair activities, negative aspects are to be noticed. Whatever the degree of truth in these assessments, the process of public administration in our country should be continuously adjusted and improved. As the debates on the role of marketing in society have increased in recent years, the tendency to extend its application areas seems to be evident; one of these is the public administration, where the ...

  5. Database Support for Research in Public Administration

    Science.gov (United States)

    Tucker, James Cory

    2005-01-01

    This study examines the extent to which databases support student and faculty research in the area of public administration. A list of journals in public administration, public policy, political science, public budgeting and finance, and other related areas was compared to the journal content list of six business databases. These databases…

  6. Effective Administrative Support for Able Teachers.

    Science.gov (United States)

    Willing, Delight C.

    1979-01-01

    The continuing education administrator should provide support that will enable teachers to perform effectively. By using Herzberg's motivation-hygiene theory as a framework, the administrator can develop a positive working environment and seek ways of providing motivation to the teacher. (SK)

  7. Supporting institutional development in land administration

    DEFF Research Database (Denmark)

    Enemark, Stig

    2006-01-01

    Land management is the process by which the resources of land are put into good effect. Land management encompasses all activities associated with the management of land and natural resources that are required to achieve sustainable development. Land Administration Systems are institutional...... implementation of efficient Land Administration Models and to support good governance. The paper identifies the role of FIG in this regard. This includes support for professional, institutional and global development in surveying and land management, and aims to facilitate the creation of sustainable...

  8. Advancing Administrative Supports for Research Development

    Science.gov (United States)

    Briar-Lawson, Katharine; Korr, Wynne; White, Barbara; Vroom, Phyllis; Zabora, James; Middleton, Jane; Shank, Barbara; Schatz, Mona

    2008-01-01

    Research administrative supports must parallel and reinforce faculty initiatives in research grant procurement. This article features several types of developments that draw on presentations at the National Association of Deans and Directors of Schools of Social Work meetings. Key changes in social work programs are addressed, including the…

  9. Evidence supporting laparoscopic major hepatectomy.

    Science.gov (United States)

    Cheek, Susannah M; Sucandy, Iswanto; Tsung, Allan; Marsh, J Wallis; Geller, David A

    2016-05-01

    Laparoscopic liver resection (LLR) has been increasing in frequency with over 9,000 cases done worldwide. Benefits of laparoscopic resection include less blood loss, smaller incisions, decreased postoperative morbidity, and shorter length of stay compared to open liver resection. With increased experience, several centers have reported series of laparoscopic major hepatectomy, although this represents only about 25% of total LLR performed. Evidence is accumulating to support laparoscopic major hepatectomy with the understanding that there is a steep learning curve, and surgeons should begin with minor LLR before moving on to laparoscopic major hepatectomy. Controversy still remains concerning indications, techniques, learning curve, risks, and long-term cancer outcomes with laparoscopic major hepatectomy. PMID:27040039

  10. 5 CFR 831.1206 - Evidence supporting entitlement to disability benefits.

    Science.gov (United States)

    2010-01-01

    ... disability benefits. 831.1206 Section 831.1206 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED) RETIREMENT Disability Retirement § 831.1206 Evidence supporting entitlement to disability benefits. (a) Evidence to support disability retirement application....

  11. Faculty: Thy Administrator's Keeper? Some Evidence

    Science.gov (United States)

    Cunningham, Brendan M.

    2009-01-01

    Colleges and universities face a principal-agent problem. There are information asymmetries over the actions chosen by administrators. Because non-profit constraints limit the financial stake of trustees there may be insufficient monitoring of administrators and, consequentially, shirking. It is conceivable that faculty will serve as "delegated…

  12. 48 CFR 45.503 - Support property administrator findings.

    Science.gov (United States)

    2010-10-01

    ... administrator findings. 45.503 Section 45.503 Federal Acquisition Regulations System FEDERAL ACQUISITION... property administrator findings. In instances where the prime contractor does not concur with the findings of the support Property Administrator, the prime property administrator shall immediately refer...

  13. Ethics in Public Administration: Evidence from Slovenia

    Directory of Open Access Journals (Sweden)

    Zlatko NEDELKO

    2013-12-01

    Full Text Available The main purpose of this paper is to examine how employees’ personal ethics, expressed through their personal values and attitudes toward social and environmental issues, are associated with the ethics of organizations in public administration. The authors introduce their own theoretical model that examines the relations between employees’ personal ethics – expressed through employees’ personal values and attitudes toward natural and social environments – and the ethics of public administration. The reported study examined these relations and tested a proposed model based on the answers of 212 employees from public administration organizations in Slovenia. Employees’ attitudes toward natural and social environments and the ethics of their organizations were measured using a questionnaire designed to measure aspects of ethics whereas personal values were measured using the Schwartz value survey. The results demonstrated that employees’ self-enhancing values significantly influence their attitudes toward the natural environment. Employees’ self-transcendence and self-enhancement values significantly influence their attitudes toward the social environment and the ethics of organizations. In addition, research results about the mediation effect of employees’ attitudes toward natural and social environments on the association between the employees’ personal values and their perception of the ethics of public administration organizations reveals that employees’ social attitudes have a significant impact on the ethics of public administration while the impact of self-transcending and self-enhancing values becomes insignificant. Based on results of testing our model we can conclude that the employee’s attitudes toward to the social environment represent a significantly more powerful predictor of ethics in public administration organizations than the employees’ personal values. These results present a solid basis for further

  14. Ethics in Public Administration: Evidence from Slovenia

    OpenAIRE

    Zlatko NEDELKO; Vojko POTOCAN

    2013-01-01

    The main purpose of this paper is to examine how employees’ personal ethics, expressed through their personal values and attitudes toward social and environmental issues, are associated with the ethics of organizations in public administration. The authors introduce their own theoretical model that examines the relations between employees’ personal ethics – expressed through employees’ personal values and attitudes toward natural and social environments – and the ethics of public administrati...

  15. Teachers' Perceptions of Administrative Support in Incentive Grant Schools

    Science.gov (United States)

    Crowder, William J., Jr.

    2013-01-01

    The purpose of this study is to investigate teachers' perceptions of administrative support in incentive grant schools. The primary objective of this study is to determine the effect of participation in an incentive grant on the perceived level of administrative support. The research questions were as follows: 1) Do teachers who are participating…

  16. Supporting Research: Environments, Administration and Libraries

    Science.gov (United States)

    MacColl, John; Jubb, Michael

    2011-01-01

    Last year, OCLC Research and the UK's Research Information Network (RIN) undertook a pair of parallel studies in the US and the UK on the theme of research support services in universities (Kroll and Forsman 2010; CIBER 2010). In the US, the library and scholarly information consultancy Kroll Research Associates was commissioned, and in the UK the…

  17. FAMILY BUSINESS ADMINISTRATION: USE OF SUPPORT STRATEGIES

    OpenAIRE

    Real, L.S.; L.A. Santos; Adamy, A.P.A.; Stefano, N.M.

    2015-01-01

    Every organization is subject to go through periods of crisis, and it becomes important now support the use of strategies that help the company and prepare it for the threats coming from the environment in which it operates. This study aims to verify the strategies used by companies providing services related to family-run companies in the central region of Rio Grande do Sul. The research is based on a multi-case study, qualitative and quantitative, and observation techniques a...

  18. The structure of decision support systems administrator next information network

    OpenAIRE

    І.Ю. Субач; П.В. Хусаінов; Міщенко, В.О.; Д.Е. Прусов

    2009-01-01

     Tasks of execute orderly administrator of special purpose information network are analyzed, and the structure and functions of the system are proved that support taking decisions in real time. Key words: information networks, information services, methods of increasing the efficiency, information evaluation, intellectual data analysis.

  19. Administrative support of novice science teachers: A multiple case study

    Science.gov (United States)

    Iacuone, Leann

    Novice science teachers leave the confines of colleges and universities to embark on a new adventure in education where they aim to influence young minds, make a difference in the world, and share their love for their content. They have learned their pedagogical skills with the support and assistance of fellow classmates, a supporting professor, and a cooperating teacher. These teachers enter their new place of employment and are met with many unexpected challenges, such as a lack of resources, no one to ask questions of, and a busy staff with already established relationships, causing them to feel an overall lack of support and resulting in many new teachers rethinking their career choice and leaving the field of education within 5 years of entering. This multiple-case study investigated the administrative support 4 novice science teachers received during an academic year and the novice teachers' perceptions of the support they received to answer the following research question: How do novice science teachers who have consistent interactions with administrators develop during their first year? To answer this question, semistructured interviews, reflection journals, observations, resumes, long-range plans, and student discipline referrals were collected. The findings from this study show novice science teachers who had incidents occur in the classroom requiring administrative assistance and guidance felt more confident in enforcing their classroom management policies and procedures as the year progressed to change student behavior. The novice science teachers perceived administrators who provided resources including technology, office supplies, science supplies, and the guidance of a mentor as supportive. Novice science teachers who engaged in dialogue after administrative observations, were provided the opportunity to attend professional development outside the district, and had a mentor who taught the same discipline made more changes to their instructional

  20. Supporting Capacity Development for Sustainable Land Administration Infrastructures

    DEFF Research Database (Denmark)

    Enemark, Stig

    2005-01-01

    Land management is the process by which the resources of land are put into good effect. Land management encompasses all activities associated with the management of land and natural resources that are required to achieve sustainable development. Land Administration Systems are institutional...... identifying an adequate response to these needs at societal, organisational and individual levels. The paper examines the capacity building concept and underpins the need for institutional development to facilitate the design and implementation of efficient Land Administration Models and to support good...

  1. 5 CFR 177.105 - Administrative claim; evidence and information to be submitted.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Administrative claim; evidence and information to be submitted. 177.105 Section 177.105 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT..., documentary evidence showing the amount of earnings actually lost. (6) Any other evidence or information...

  2. New Evidence: Data Documenting Parental Support for Earlier Sexuality Education

    Science.gov (United States)

    Barr, Elissa M.; Moore, Michele J.; Johnson, Tammie; Forrest, Jamie; Jordan, Melissa

    2014-01-01

    Background: Numerous studies document support for sexuality education to be taught in high school, and often, in middle school. However, little research has been conducted addressing support for sexuality education in elementary schools. Methods: As part of the state Behavioral Risk Factor Surveillance System (BRFSS) Survey administration, the…

  3. Are claims made in orthodontic journal advertisements evidence-supported?

    NARCIS (Netherlands)

    Livas, Christos; Kouskoura, Thaleia; Ren, Yijin; Katsaros, Christos; Pandis, Nikolaos

    2015-01-01

    Objective: To examine the supporting evidence of advertisements published in six leading orthodontic journals. Materials and Methods: The 2012-2013 printed issues of American Journal of Orthodontics and Dentofacial Orthopedics, Australian Orthodontic Journal, Journal of Orthodontics, European Journa

  4. How Program Administrators Can Support Out-of-School Time Staff. Part 4 in a Series on Implementing Evidence-Based Practices in Out-of-School Time Programs: The Role of Organizational Context and External Influences. Research-to-Results Brief. Publication #2009-32

    Science.gov (United States)

    Collins, Ashleigh; Metz, Allison J. R.

    2009-01-01

    Implementing high-quality out-of-school time programs requires well-trained and well-prepared frontline staff who are supported by informed, competent, and committed program managers and administrators. Research on out-of-school time programs has found that effective program managers--referred to as "facilitative administrators"--promote…

  5. Scientific Evidence on the Supportive Cancer Care with Chinese Medicine

    Directory of Open Access Journals (Sweden)

    William CS CHO

    2010-03-01

    Full Text Available Complementary and alternative medicine has been increasingly utilized by cancer patients in developed countries. Among the various forms of complementary and alternative medicine, Traditional Chinese Medicine is one of the few that has a well constructed theoretical framework and established treatment approaches for diseases including cancer. Recent research has revealed growing evidence suggesting that Traditional Chinese Medicine is effective in the supportive care of cancer patients during and after major conventional cancer treatments. This paper succinctly summarizes some published clinical evidence and meta-analyses which support the usage of various Traditional Chinese Medicine treatment strategies including Chinese herbal medicine, acupuncture and Qigong in supportive cancer care.

  6. Evidence-based practice: developing mentors to support students.

    Science.gov (United States)

    Barry, Debbie; Houghton, Trish; Warburton, Tyler

    2016-08-17

    This article, the ninth in a series of 11, provides guidance for new and established mentors and practice teachers on evidence-based practice, the seventh domain of the Nursing and Midwifery Council's Standards to Support Learning and Assessment in Practice (SSLAP). Evidence-based practice is an important aspect of contemporary healthcare and is central to student preparation programmes for nursing, midwifery and specialist community public health nursing (SCPHN). The article describes evidence-based practice, discussing the importance and implementation of an evidence-based approach in the context of role development for mentors and practice teachers in the preparation of nursing, midwifery and SCPHN students. PMID:27533414

  7. Helping Administrators Recruit and Support School Library Information Specialists

    Science.gov (United States)

    Klais, Madge; Bugher, Kate

    2010-01-01

    School library professionals often complain that their principal or district-level administrators have a poor understanding of the work that they do. Reasons for this are varied and have been well documented in school library literature. The bottom line is that administrators' lack of education regarding the important contributions that the school…

  8. Planning the future of JPL's management and administrative support systems around an integrated database

    Science.gov (United States)

    Ebersole, M. M.

    1983-01-01

    JPL's management and administrative support systems have been developed piece meal and without consistency in design approach over the past twenty years. These systems are now proving to be inadequate to support effective management of tasks and administration of the Laboratory. New approaches are needed. Modern database management technology has the potential for providing the foundation for more effective administrative tools for JPL managers and administrators. Plans for upgrading JPL's management and administrative systems over a six year period evolving around the development of an integrated management and administrative data base are discussed.

  9. DECENTRALIZATION, ELIGIBILITY OF AUTHORITIES AND CONSULTATION OF CITIZENS - EVIDENCE OF THE OCCURRENCE OF AUTONOMY IN LOCAL PUBLIC ADMINISTRATION MANAGEMENT

    Directory of Open Access Journals (Sweden)

    ZAHARIA PETRONELA

    2013-04-01

    Full Text Available Being important for the proper functioning of the management activity conducted at the local public administration level, local autonomy cannot occur without the support coming from other rules of organization and functioning of local administrative system. From this perspective, in this paper we propose to analyze the content of decentralization, eligibility of authorities and consultation of citizens in solving local problems, in order to highlight how each of these principles demonstrates the efficiency of autonomy. Moving power from central public administration authorities to local authorities in the decentralization process, making authorities of administrative-territorial units eligible and the involvement of local community members in solving problems affecting them are clear evidence of the occurrence of autonomy in local public administration management.

  10. Are claims made in orthodontic journal advertisements evidence-supported?

    OpenAIRE

    Livas, Christos; Kouskoura, Thaleia; Ren, Yijin; Katsaros, Christos; Pandis, Nikolaos

    2015-01-01

    OBJECTIVE To examine the supporting evidence of advertisements published in six leading orthodontic journals. MATERIALS AND METHODS The 2012-2013 printed issues of American Journal of Orthodontics and Dentofacial Orthopedics, Australian Orthodontic Journal, Journal of Orthodontics, European Journal of Orthodontics, Journal of Clinical Orthodontics, and Journal of Orofacial Orthopedics were screened for advertisements implying superior performance compared with competitor products....

  11. Administrative Supports of Teachng Partnerships Between General and Special Educators

    OpenAIRE

    Burdette, Paula Jeanne

    1999-01-01

    As educators are held accountable for student outcomes more frequently, more stringently, and more fully throughout the school organization, service delivery systems have become a focus. Not only are teachers being held accountable for students' learning, but also principals and other administrators are beginning to feel the pressure from public concerns regarding the education of children in the United States. The quality of student instruction can be addressed through practical service deli...

  12. NICU nurse educators: what evidence supports your teaching strategies?

    Science.gov (United States)

    Pilcher, Jobeth

    2013-01-01

    One of our roles as nurse educators is to teach best practices related to patient care. However, have you ever stopped to think about what evidence supports your teaching strategies? Just as our patients deserve care that is based on the best available evidence, our learners also deserve education that is based on evidence.1-3 With so many advances in knowledge, technology, and even life itself, it is interesting that education has changed very little over the past 100 years. A study among 946 nurse educators documented that most teach the way they were taught.4 In addition, even after learning new strategies, educators often continue teaching in the manner they are most comfortable. However, this trend is beginning to change. Nurse educators are becoming increasingly aware of and willing to try new and innovative teaching strategies. Educators are also seeking out evidence-based teaching strategies and are becoming more involved in nursing education research. PMID:23835547

  13. Support from Chief Executives to Sponsored Programs Administration at Baccalaureate Universities in the United States

    Science.gov (United States)

    Hamilton, Zoya

    2012-01-01

    This research study examined support to sponsored programs administrators (SPAs, or research administrators) at baccalaureate universities from their chief executives. Support to SPAs strengthens the shared purpose of the university, enabling SPAs to serve as effective organizational representatives in business transactions pertaining to grants…

  14. Administrative Support and Its Mediating Effect on US Public School Teachers

    Science.gov (United States)

    Tickle, Benjamin R.; Chang, Mido; Kim, Sunha

    2011-01-01

    This study examined the effect of administrative support on teachers' job satisfaction and intent to stay in teaching. The study employed a path analysis to the data of regular, full-time, public school teachers from the Schools and Staffing Survey teacher questionnaire. Administrative support was the most significant predictor of teachers' job…

  15. Healthcare Decision Support System for Administration of Chronic Diseases

    OpenAIRE

    Woo, Ji-In; Yang, Jung-Gi; Lee, Young-Ho; Kang, Un-Gu

    2014-01-01

    Objectives A healthcare decision-making support model and rule management system is proposed based on a personalized rule-based intelligent concept, to effectively manage chronic diseases. Methods A Web service was built using a standard message transfer protocol for interoperability of personal health records among healthcare institutions. An intelligent decision service is provided that analyzes data using a service-oriented healthcare rule inference function and machine-learning platform; ...

  16. The support of human genetic evidence for approved drug indications.

    Science.gov (United States)

    Nelson, Matthew R; Tipney, Hannah; Painter, Jeffery L; Shen, Judong; Nicoletti, Paola; Shen, Yufeng; Floratos, Aris; Sham, Pak Chung; Li, Mulin Jun; Wang, Junwen; Cardon, Lon R; Whittaker, John C; Sanseau, Philippe

    2015-08-01

    Over a quarter of drugs that enter clinical development fail because they are ineffective. Growing insight into genes that influence human disease may affect how drug targets and indications are selected. However, there is little guidance about how much weight should be given to genetic evidence in making these key decisions. To answer this question, we investigated how well the current archive of genetic evidence predicts drug mechanisms. We found that, among well-studied indications, the proportion of drug mechanisms with direct genetic support increases significantly across the drug development pipeline, from 2.0% at the preclinical stage to 8.2% among mechanisms for approved drugs, and varies dramatically among disease areas. We estimate that selecting genetically supported targets could double the success rate in clinical development. Therefore, using the growing wealth of human genetic data to select the best targets and indications should have a measurable impact on the successful development of new drugs. PMID:26121088

  17. Building a knowledge translation platform in Malawi to support evidence-informed health policy.

    Science.gov (United States)

    Berman, Joshua; Mitambo, Collins; Matanje-Mwagomba, Beatrice; Khan, Shiraz; Kachimanga, Chiyembekezo; Wroe, Emily; Mwape, Lonia; van Oosterhout, Joep J; Chindebvu, Getrude; van Schoor, Vanessa; Puchalski Ritchie, Lisa M; Panisset, Ulysses; Kathyola, Damson

    2015-01-01

    With the support of the World Health Organization's Evidence-Informed Policy Network, knowledge translation platforms have been developed throughout Africa, the Americas, Eastern Europe, and Asia to further evidence-informed national health policy. In this commentary, we discuss the approaches, activities and early lessons learned from the development of a Knowledge Translation Platform in Malawi (KTPMalawi). Through ongoing leadership, as well as financial and administrative support, the Malawi Ministry of Health has strongly signalled its intention to utilize a knowledge translation platform methodology to support evidence-informed national health policy. A unique partnership between Dignitas International, a medical and research non-governmental organization, and the Malawi Ministry of Health, has established KTPMalawi to engage national-level policymakers, researchers and implementers in a coordinated approach to the generation and utilization of health-sector research. Utilizing a methodology developed and tested by knowledge translation platforms across Africa, a stakeholder mapping exercise and initial capacity building workshops were undertaken and a multidisciplinary Steering Committee was formed. This Steering Committee prioritized the development of two initial Communities of Practice to (1) improve data utilization in the pharmaceutical supply chain and (2) improve the screening and treatment of hypertension within HIV-infected populations. Each Community of Practice's mandate is to gather and synthesize the best available global and local evidence and produce evidence briefs for policy that have been used as the primary input into structured deliberative dialogues. While a lack of sustained initial funding slowed its early development, KTPMalawi has greatly benefited from extensive technical support and mentorship by an existing network of global knowledge translation platforms. With the continued support of the Malawi Ministry of Health and the

  18. Trichloroethylene: Mechanistic, epidemiologic and other supporting evidence of carcinogenic hazard.

    Science.gov (United States)

    Rusyn, Ivan; Chiu, Weihsueh A; Lash, Lawrence H; Kromhout, Hans; Hansen, Johnni; Guyton, Kathryn Z

    2014-01-01

    The chlorinated solvent trichloroethylene (TCE) is a ubiquitous environmental pollutant. The carcinogenic hazard of TCE was the subject of a 2012 evaluation by a Working Group of the International Agency for Research on Cancer (IARC). Information on exposures, relevant data from epidemiologic studies, bioassays in experimental animals, and toxicity and mechanism of action studies was used to conclude that TCE is carcinogenic to humans (Group 1). This article summarizes the key evidence forming the scientific bases for the IARC classification. Exposure to TCE from environmental sources (including hazardous waste sites and contaminated water) is common throughout the world. While workplace use of TCE has been declining, occupational exposures remain of concern, especially in developing countries. The strongest human evidence is from studies of occupational TCE exposure and kidney cancer. Positive, although less consistent, associations were reported for liver cancer and non-Hodgkin lymphoma. TCE is carcinogenic at multiple sites in multiple species and strains of experimental animals. The mechanistic evidence includes extensive data on the toxicokinetics and genotoxicity of TCE and its metabolites. Together, available evidence provided a cohesive database supporting the human cancer hazard of TCE, particularly in the kidney. For other target sites of carcinogenicity, mechanistic and other data were found to be more limited. Important sources of susceptibility to TCE toxicity and carcinogenicity were also reviewed by the Working Group. In all, consideration of the multiple evidence streams presented herein informed the IARC conclusions regarding the carcinogenicity of TCE. PMID:23973663

  19. Decision support for health care: the PROforma evidence base

    Directory of Open Access Journals (Sweden)

    John Fox

    2006-03-01

    Full Text Available Cancer Research UK has developed PROforma, a formal language for modelling clinical processes, along with associated tools for creating decision support, care planning, clinical workflow management and other applications. The PROforma method has been evaluated in a variety of settings: in primary health care (prescribing, referral of suspected cancer patients, genetic risk assessment and in specialist care of patients with breast cancer, leukaemia, HIV infection and other conditions. About nine years of experience have been gained with PROforma technologies. Seven trials of decision support applications have been published or are in preparation. Each of these has shown significant positive effects on a variety of measures of quality and/or outcomes of care. This paper reviews the evidence base for the clinical effectiveness of these PROforma applications, and previews the CREDO project _a multi-centre trial of a complex PROforma application for supporting integrated breast cancer care across primary and secondary care settings.

  20. 31 CFR 285.1 - Collection of past-due support by administrative offset.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Collection of past-due support by administrative offset. 285.1 Section 285.1 Money and Finance: Treasury Regulations Relating to Money and Finance... such exemptions, the Secretary shall give due consideration to whether administrative offset would...

  1. Oxygen saturation limits and evidence supporting the targets.

    Science.gov (United States)

    Newnam, Katherine M

    2014-12-01

    Supplemental oxygen use in the preterm infant is required for survival. Evidence supports a narrow therapeutic window between the helpful and harmful effects of supplemental oxygen in this vulnerable population. The clinical question was-what are the recommended oxygen saturation targets for the preterm infant and the preterm infant corrected to term? Multiple databases were searched for published research in English from 2008 to 2014 using key search terms. A total of 18 articles met inclusion criteria. Early neonatal research linked high levels of supplemental oxygen with retinopathy of prematurity and blindness. Years later, correlations between high arterial oxygen levels and oxidative stress leading to pulmonary and/or neurologic insults were established. Three large multicentered, international studies have recently been published (BOOST II, COT, and SUPPORT), which support oxygen saturation target ranges of 87% to 94% until vascular maturation of the retina is achieved. Two of the 3 studies reported a significant correlation between low saturation limits (85%-89%) and death in the extremely preterm population. Identified best care strategies to prevent states of hypoxia and/or hyperoxia include establishing clear target saturation limits according to recommendations, which are supported by the multidisciplinary team, adequate nurse to patient ratio, improve knowledge deficits, improve bedside compliance, and finally visual cues to remind caregivers of target saturation ranges. PMID:25422926

  2. Shifting Spaces and Emerging Voices: Participation, Support, and Conflict in One School Administrative Team

    Science.gov (United States)

    Austin, Manila S.; Harkins, Debra A.

    2008-01-01

    Research Findings: Collaborative work and supportive relationships are highly valued by teachers and school administrators. Collaboration, however, necessitates constructive conflict resolution (P. M. Senge, 1990); yet conflict is often experienced as interpersonally threatening and undermining supportive working conditions. This contradiction is…

  3. Job Design: An Administrator's Guide to Supporting and Retaining Special Educators

    Science.gov (United States)

    Bettini, Elizabeth A.; Cheyney, Kristi; Wang, Jun; Leko, Christopher

    2015-01-01

    Special education teacher attrition has numerous negative impacts for students and schools. Administrators play an essential role in supporting special educators, but they seldom receive adequate preparation to provide this support effectively. The authors synthesize job characteristics theory, an area of research conducted by organizational…

  4. Neuroanatomical Evidence in Support of the Bilingual Advantage Theory.

    Science.gov (United States)

    Olulade, O A; Jamal, N I; Koo, D S; Perfetti, C A; LaSasso, C; Eden, G F

    2016-07-01

    The "bilingual advantage" theory stipulates that constant selection and suppression between 2 languages results in enhanced executive control (EC). Behavioral studies of EC in bilinguals have employed wide-ranging tasks and report some conflicting results. To avoid concerns about tasks, we employed a different approach, measuring gray matter volume (GMV) in adult bilinguals, reasoning that any EC-associated benefits should manifest as relatively greater frontal GMV. Indeed, Spanish-English-speaking bilinguals exhibited greater bilateral frontal GMV compared with English-speaking monolinguals. Was this observation attributable to the constant selection and inhibition of 2 spoken languages? To answer this question, we drew on bimodal bilinguals of American Sign Language (ASL) and English who, unlike unimodal bilinguals, can simultaneously use both languages and have been shown not to possess the EC advantage. In this group, there was no greater GMV when compared with monolinguals. Together these results provide neuroanatomical evidence in support of the bilingual advantage theory. PMID:26184647

  5. Lack of Evidence Supporting the Effectiveness of Disaster Supply Kits.

    Science.gov (United States)

    Heagele, Tara N

    2016-06-01

    We reviewed the available evidence in support of the effectiveness of disaster supply kits presently used in household emergency preparedness in the United States. The expectation that people should take responsibility for their own disaster preparedness has largely not taken into account contextual influences on disaster preparedness. The efficiency of current disaster supply kits used during critical postdisaster periods has not been empirically tested. Professional recommendations regarding the composition of disaster supply kits containing at least water, food, first aid, hygiene, and clothing have not been universally defined. This lack of consensus may lead to the assembling of disaster supply kits yielding suboptimal results. The use of disaster supply kits should continue to be nationally recommended, although additional research is needed to demonstrate their beneficial impact on survival and resilience after a disaster. PMID:27077362

  6. 34 CFR 35.4 - Administrative claim; evidence and information to be submitted.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Administrative claim; evidence and information to be submitted. 35.4 Section 35.4 Education Office of the Secretary, Department of Education TORT CLAIMS AGAINST... cost of such repairs. (4) A statement listing date of purchase, purchase price, market value of...

  7. The Validity of Reading Comprehension Test Scores: Evidence of Generalizability across Different Test Administration Conditions.

    Science.gov (United States)

    Bishop, N. Scott

    This study examined the effects of different test administration conditions on reading comprehension test scores. Evidence of performance differences across district testing conditions might imply that the meanings and interpretations associated with the corresponding test scores have limited generalizability (i.e., knowing how well one reads…

  8. The Effects of Teacher Perceptions of Administrative Support, School Climate, and Academic Success in Urban Schools

    Science.gov (United States)

    Robinson, Lakishia N.

    2015-01-01

    Teacher turnover refers to major changes in teachers' assignments from one school year to the next. Past research has given an overview of several factors of teacher turnover. These factors include the school environment, teacher collaborative efforts, administrative support, school climate, location, salary, classroom management, academic…

  9. 76 FR 63509 - Small Business Size Standards: Administrative and Support, Waste Management and Remediation Services

    Science.gov (United States)

    2011-10-12

    ... commissions (such as real estate brokers and travel agents), $5 million include those industries with the... industry data might support a distinct size standard for each industry (see 57 FR 27906 (June 23, 1992... industries in North American Industry Classification System (NAICS) Sector 56, Administrative and...

  10. Divisions among Us: Women Administrators, Faculty, and Staff on the Complicated Realities of Support and Sisterhood

    Science.gov (United States)

    Vaccaro, Annemarie

    2011-01-01

    Although Robin Morgan argued that sisterhood is powerful (1970) and forever (2003), results from this case study show that sisterhood is not easily achieved, even in women's groups in which support for women was a formal goal. Narratives of eight women faculty, middle managers, and top administrators reveal that organizational sexism and women's…

  11. Improvements of Decision Support Systems for Public Administrations via a Mechanism of Co-creation of Value

    Directory of Open Access Journals (Sweden)

    Tindara Abbate

    2015-04-01

    Full Text Available This paper focuses on a possible improvement of knowledge-based decision support systems for human resource management within Public Administrations, using a co-creation of value’s mechanism, according to the Service-Dominant Logic (SDL paradigm. In particular, it applies ontology-driven data entry procedures to trigger the cooperation between the Public Administration itself and its employees. Advantages in such sense are evident: constraining the data entry process by means of the term definition ontology improves the quality of gathered data, thus reducing potential mismatching problems and allowing a suitable skill gap analysis among real and ideal workers competence profiles. The procedure foresees the following steps: analyzing organograms and job descriptions; modelling Knowledge, Skills and Attitudes (KSA for job descriptions; transforming KSAs of job descriptions into a standard-based model with integrations of other characteristics; extracting information from Curricula Vitae according to the selected model; comparing profiles and roles played by the employees.The 'a priori' ontology-driven approach adequately supports the operations that involve both the Public Administration and employees, as for the data storage of job descriptions and curricula vitae. The comparison step is useful to understand if employees perform roles that are coherent with their own professional profiles.The proposed approach has been experimented on a small test case and the results show that its objective evaluation represents an improvement for a decision support system for the re-organization of Italian Public Administrations where, unfortunately often, people are engaged in activities that are not so close to their competences.

  12. Administration

    DEFF Research Database (Denmark)

    Bogen handler om den praksis, vi kalder administration. Vi er i den offentlige sektor i Danmark hos kontorfolkene med deres sagsmapper, computere, telefoner,, lovsamlinger,, retningslinier og regneark. I bogen udfoldes en mangfoldighed af konkrete historier om det administrative arbejde fra...... forskellige områder i den offentlige sektor. Hensigten er at forstå den praksis og faglighed der knytter sig til det administrative arbejde...

  13. Evidence based administration of risperidone and paliperidone for the treating conduct disorder

    OpenAIRE

    Ahmad Ghanizadeh

    2013-01-01

    Background: This study evaluates the evidence-based administration of risperidone and paliperidone for the treating children and adolescents with conduct disorder (CD). Materials and Methods: A review of the current literature from clinical trials that investigated the efficacy of risperidone and paliperidone on CD considering the inclusion criteria and search strategies was performed by a search of PubMed and Google Scholar databases. Results: Out of 53 titles, 31 were irrelevant. The abstra...

  14. Evidence supporting the use of recombinant activated factor VII in congenital bleeding disorders

    Directory of Open Access Journals (Sweden)

    Pär I Johansson

    2010-06-01

    Full Text Available Pär I Johansson, Sisse R OstrowskiCapital Region Blood Bank, Section for Transfusion Medicine, Rigshospitalet, University of Copenhagen, Copenhagen, DenmarkBackground: Recombinant activated factor VII (rFVIIa, NovoSeven® was introduced in 1996 for the treatment of hemophilic patients with antibodies against coagulation factor VIII or IX.Objective: To review the evidence supporting the use of rFVIIa for the treatment of patients with congenital bleeding disorders.Patients and methods: English-language databases were searched in September 2009 for reports of randomized controlled trials (RCTs evaluating the ability of rFVIIa to restore hemostasis in patients with congenital bleeding disorders.Results: Eight RCTs involving 256 hemophilic patients with antibodies against coagulation factors, also known as inhibitors, were identified. The evidence supporting the use of rFVIIa in these patients was weak with regard to dose, clinical setting, mode of administration, efficacy, and adverse events, given the limited sample size of each RCT and the heterogeneity of the studies.Conclusion: The authors suggest that rFVIIa therapy in hemophilic patients with inhibitors should be based on the individual’s ability to generate thrombin and form a clot, and not on the patient’s weight alone. Therefore, assays for thrombin generation, such as whole-blood thromboelastography, have the potential to significantly improve the treatment of these patients.Keywords: hemophilia, inhibitors, coagulation factor VIII, coagulation factor IX, rFVIIa, NovoSeven, FEIBA, hemostasis, RCT

  15. Professional Parity Between Co-Teachers in Secondary Science and Math As Influenced By Administrative Support

    Science.gov (United States)

    Nordh, Camilla S.

    2011-12-01

    School improvement plans, budget constraints, and compliance mandates targeting academic progress for all students indicate a need for maximal professional efficacy at every level in the educational system, including parity between co-teachers in the co-teaching service delivery model. However, research shows that the special education co-teacher frequently assumes an assistive role while the general education co-teacher adopts a leading role in the classroom. When the participants in a co-teaching partnership fail to equitably share the professional responsibilities for which both teachers are qualified to perform, overall efficacy is compromised in that the special education teacher is not exercising his or her qualified expertise. Administrative support can be a primary influencing factor in increasing parity between the co-teachers. A qualitative study using a phenomenological design was conducted to explore the influences of co-teacher attitudes and administrative support on professional parity in co-taught secondary science and math classrooms. Content analysis was used to interpret data from interviews with five special education and 15 general education co-teachers at eight secondary schools in a suburban school district in a mid-Atlantic state. Five themes emerged from the data: content mastery by the special education co-teacher, joint planning time for co-teachers, continuity within co-teaching dyads, compatible personalities between co-teachers, and clear administrative expectations about co-teaching. Results indicate that administrative support to consider the content mastery of the special education co-teacher is the most influential factor to parity, followed by the co-teaching partners having joint planning time and that both can be implemented through scheduling and assignment considerations rather than training initiatives. The results provide an examination of each theme as it pertains to the issue of professional efficacy in co-teaching and

  16. Building Your Program. Supported Education: A Promising Practice. Evidence-Based Practices KIT (Knowledge Informing Transformation)

    Science.gov (United States)

    Unger, Karen V.

    2011-01-01

    "Building Your Program" is intended to help mental health authorities, agency administrators, and program leaders think through and develop Supported Education. The first part of this booklet gives you background information about the Supported Education model. Specific information about your role in implementing and sustaining Supported Education…

  17. Standardized Nursing Documentation Supports Evidence-Based Nursing Management.

    Science.gov (United States)

    Mykkänen, Minna; Miettinen, Merja; Saranto, Kaija

    2016-01-01

    Nursing documentation is crucial to high quality, effective and safe nursing care. According to earlier studies nursing documentation practices vary and nursing classifications used in electronic patient records (EPR) are not yet standardized internationally nor nationally. A unified national model for documenting patient care improves information flow in nursing practice, management, research and development toward evidence-based nursing care. Nursing documentation quality, accuracy and development requires follow-up and evaluation. An audit instrument is used in the Kuopio University Hospital (KUH) when evaluating nursing documentation. The results of the auditing process suggest that the national nursing documentation model fulfills nurses' expectations of electronic tools, facilitating their important documentation duty. This paper discusses the importance of using information about nursing documentation and how we can take advantage of structural information in evidence-based nursing management. PMID:27332244

  18. Trichloroethylene: Mechanistic, Epidemiologic and Other Supporting Evidence of Carcinogenic Hazard

    OpenAIRE

    Rusyn, Ivan; Chiu, Weihsueh A.; Lawrence H. Lash; Kromhout, Hans; Hansen, Johnni; Guyton, Kathryn Z.

    2013-01-01

    The chlorinated solvent trichloroethylene (TCE) is a ubiquitous environmental pollutant. The carcinogenic hazard of TCE was the subject of a 2012 evaluation by a Working Group of the International Agency for Research on Cancer (IARC). Information on exposures, relevant data from epidemiologic studies, bioassays in experimental animals, and toxicity and mechanism of action studies was used to conclude that TCE is carcinogenic to humans (Group 1). This article summarizes the key evidence formin...

  19. Supporting the education evidence portal via text mining

    OpenAIRE

    Ananiadou, Sophia; Thompson, Paul; Thomas, James; Mu, Tingting; Oliver, Sandy; Rickinson, Mark; Sasaki, Yutaka; Weissenbacher, Davy; McNaught, John

    2010-01-01

    The UK Education Evidence Portal (eep) provides a single, searchable, point of access to the contents of the websites of 33 organizations relating to education, with the aim of revolutionizing work practices for the education community. Use of the portal alleviates the need to spend time searching multiple resources to find relevant information. However, the combined content of the websites of interest is still very large (over 500 000 documents and growing). This means that searches using th...

  20. Self Directed Support and People with Learning Disabilities: A Review of the Published Research Evidence

    Science.gov (United States)

    Harkes, Mary Anne; Brown, Michael; Horsburgh, Dorothy

    2014-01-01

    A systematic literature review was undertaken to determine the evidence base underpinning the strategy of Self Directed Support and whether evidence demonstrates that this policy is accessible to everyone with a learning disability. It also sought to identify whether there were any barriers to Self Directed Support for people with severe or…

  1. Perceived Organizational Support: Further Evidence of Construct Validity.

    Science.gov (United States)

    Hutchison, Steven

    1997-01-01

    Confirmatory factor analysis was used to examine the construct validity of scores from the Survey of Perceived Organizational Support (SPOS)(R. Eisenberger and others, 1986) using responses of 205 college faculty and staff members. Consistent with previous research, the SPOS was found to be unidimensional and distinguishable from two similarly…

  2. The Generational Divide in Support for Environmental Policies: European Evidence

    OpenAIRE

    Joni Hersch; W. Kip Viscusi

    2005-01-01

    This article examines age variations in support for environmental protection policies that affect climate change using a sample of over 14,000 respondents to a 1999 Eurobarometer survey. There is a steady decline with age in whether respondents are willing to incur higher gasoline prices to protect the environment. This relationship remains after controlling for socioeconomic characteristics. There are age-related differences in information about environmental risks, information sources about...

  3. m-Health for antiretroviral treatment support : evidence from India

    OpenAIRE

    Rodrigues, Rashmi Josephine

    2014-01-01

    Background: With antiretroviral therapy (ART) HIV infection is now managed like a chronic disease rather than as a fatal disease. Adherence to ART is essential for treatment success. However the high levels of adherence that are necessary and the multifactorial nature of adherence, make adherence to ART a challenge. The recent years have seen a move towards the development of low cost interventions to support adherence to ART. The ...

  4. Introduction of soft budget constraint to analyze public administration reforms. Some evidence from the Hungarian public administration reform

    OpenAIRE

    Rosta, Miklós

    2015-01-01

    Public management reforms are usually underpinned by arguments that they will make the public administration system more effective and efficient. In practice, however, it is very hard to determine whether a given reform will improve the efficiency and effectiveness of the public administration system in the long run. Here, I shall examine how the concept of the soft budget constraint (SBC) introduced by János Kornai (Kornai 1979, 1986; Kornai, Maskin and Roland 2003) can be applied to this pr...

  5. Being baby friendly: evidence-based breastfeeding support.

    Science.gov (United States)

    Cleminson, J; Oddie, S; Renfrew, M J; McGuire, W

    2015-03-01

    Breast feeding improves important outcomes for mothers and infants. In the UK, breastfeeding rates have historically been low, particularly among socially disadvantaged young women. Although there have been gradual increases in breastfeeding initiation rates since 2000, rates of exclusive breast feeding and continuation until 6 months remain lower than those in similar countries. This review summarises the evidence for effective and cost-effective strategies to help women, particularly those in low income groups, make informed choices, overcome barriers and establish and maintain breast feeding. We describe the development and impact of the Unicef Baby Friendly Initiative, and the roles and responsibilities, and challenges and opportunities that clinicians have in promoting breast feeding and maintaining a baby-friendly culture and environment. PMID:25293712

  6. Dental School Administrators' Attitudes Towards Providing Support Services for LGBT-Identified Students.

    Science.gov (United States)

    Behar-Horenstein, Linda S; Morris, Dustin R

    2015-08-01

    A lack of curriculum time devoted to teaching dental students about the needs of lesbian, gay, bisexual, and transgendered (LGBT) health care patient needs and biases against LGBT students and faculty have been reported. Understanding dental school administrators' attitudes about LGBT students' needs might provide further insight into these long-standing issues. The aims of this study were to develop a survey to assess dental administrators' attitudes regarding the support services they believe LGBT-identified students need, to identify dental schools' current diversity inclusion policies, and to determine what types of support dental schools currently provide to LGBT students. A survey developed with the aid of a focus group, cognitive interviewing, and pilot testing was sent to 136 assistant and associate deans and deans of the 65 U.S. and Canadian dental schools. A total of 54 responses from 43 (66%) schools were received from 13 deans, 29 associate deans, and 11 assistant deans (one participant did not report a position), for a 40% response rate. The findings suggest there is a considerable lack of knowledge or acknowledgment of LGBT dental students' needs. Future studies are needed to show the importance of creating awareness about meeting the needs of all dental student groups, perhaps through awareness campaigns initiated by LGBT students. PMID:26246536

  7. Health awareness days: sufficient evidence to support the craze?

    Science.gov (United States)

    Purtle, Jonathan; Roman, Leah A

    2015-06-01

    Health awareness initiatives are a ubiquitous intervention strategy. Nearly 200 health awareness days, weeks, and months are on the US National Health Observances calendar, and more than 145 awareness day bills have been introduced in Congress since 2005. We contend that health awareness days are not held to appropriate scrutiny given the scale at which they have been embraced and are misaligned with research on the social determinants of health and the tenets of ecological models of health promotion. We examined health awareness days from a critical public health perspective and offer empirically supported recommendations to advance the intervention strategy. If left unchecked, health awareness days may do little more than reinforce ideologies of individual responsibility and the false notion that adverse health outcomes are simply the product of misinformed behaviors. PMID:25879148

  8. Supporting the education evidence portal via text mining.

    Science.gov (United States)

    Ananiadou, Sophia; Thompson, Paul; Thomas, James; Mu, Tingting; Oliver, Sandy; Rickinson, Mark; Sasaki, Yutaka; Weissenbacher, Davy; McNaught, John

    2010-08-28

    The UK Education Evidence Portal (eep) provides a single, searchable, point of access to the contents of the websites of 33 organizations relating to education, with the aim of revolutionizing work practices for the education community. Use of the portal alleviates the need to spend time searching multiple resources to find relevant information. However, the combined content of the websites of interest is still very large (over 500,000 documents and growing). This means that searches using the portal can produce very large numbers of hits. As users often have limited time, they would benefit from enhanced methods of performing searches and viewing results, allowing them to drill down to information of interest more efficiently, without having to sift through potentially long lists of irrelevant documents. The Joint Information Systems Committee (JISC)-funded ASSIST project has produced a prototype web interface to demonstrate the applicability of integrating a number of text-mining tools and methods into the eep, to facilitate an enhanced searching, browsing and document-viewing experience. New features include automatic classification of documents according to a taxonomy, automatic clustering of search results according to similar document content, and automatic identification and highlighting of key terms within documents. PMID:20643679

  9. Evidence based administration of risperidone and paliperidone for the treating conduct disorder

    Directory of Open Access Journals (Sweden)

    Ahmad Ghanizadeh

    2013-01-01

    Full Text Available Background: This study evaluates the evidence-based administration of risperidone and paliperidone for the treating children and adolescents with conduct disorder (CD. Materials and Methods: A review of the current literature from clinical trials that investigated the efficacy of risperidone and paliperidone on CD considering the inclusion criteria and search strategies was performed by a search of PubMed and Google Scholar databases. Results: Out of 53 titles, 31 were irrelevant. The abstract of 22 potentially related articles were studied. Only six articles reported the results of clinical trial. However, one of them reported the effect of risperidone on conduct behaviors in autistic disorders. One study was a re-analysis of two previous studies, one study reported the effects of maintenance versus withdrawal of risperidone treatment and two studies included children with sub-average intelligence. Headache, somnolence and increased appetite are among the most common reported adverse effects. No study examined the effect of paliperidone on CD was found. Conclusion: Current literature suggests that risperidone could be effective for treating some conduct behaviors in children and adolescents. The effect of risperidone on CD is not a well-researched area. There is no well-controlled evidence based reports about the safety and efficacy of risperidone for the treatment of CD. Further trials should examine the efficacy of these medications on CD rather than conduct behaviors or disruptive behavior disorders.

  10. ESTIMATION OF LEVEL OF RISKS IN THE SYSTEM OF SUPPORT OF ADMINISTRATIVE DECISIONS FOR OPERATORS OF THE FORWARDING ENTERPRISES

    OpenAIRE

    Androsenko, V.

    2010-01-01

    The analysis and the description of the procedure of the estimation of the level of risks in the system of support of administrative decisions for operators of the forwarding enterprises on the basis of preliminary collected information is carried out.

  11. World Politics and Support for Terrorism within Muslim Populations: Evidence from Muslim Countries and Western Europe

    OpenAIRE

    Kirill Zhirkov; Maykel Verkuyten; Jeroen Weesie

    2013-01-01

    World Politics and Support for Terrorism within Muslim Populations: Evidence from Muslim Countries and Western Europe countries, we examine the levels of support for suicide bombings and other forms of violence. We found that support for terrorism among Muslims is present but the percentage of radicals is quite low. In both samples, support for terrorism is stronger among those who see democracy as a solely Western political system. This pattern of association is similar across the Western Eu...

  12. 27 CFR 53.176 - Supporting evidence required in case of price readjustments.

    Science.gov (United States)

    2010-04-01

    ... sufficient available evidence: (a) Describing the circumstances which gave rise to the price readjustment, (b... required in case of price readjustments. 53.176 Section 53.176 Alcohol, Tobacco Products and Firearms... to Manufacturers Taxes § 53.176 Supporting evidence required in case of price readjustments....

  13. Mephedrone (4-methylmethcathinone) supports intravenous self-administration in Sprague-Dawley and Wistar rats.

    Science.gov (United States)

    Aarde, Shawn M; Angrish, Deepshikha; Barlow, Deborah J; Wright, M Jerry; Vandewater, Sophia A; Creehan, Kevin M; Houseknecht, Karen L; Dickerson, Tobin J; Taffe, Michael A

    2013-09-01

    Recreational use of the drug 4-methylmethcathinone (mephedrone; 4-MMC) became increasingly popular in the United Kingdom in recent years, spurred in part by the fact that it was not criminalized until April 2010. Although several fatalities have been associated with consumption of 4-MMC and cautions for recreational users about its addictive potential have appeared on Internet forums, very little information about abuse liability for this drug is available. This study was conducted to determine if 4-MMC serves as a reinforcer in a traditional intravenous self-administration model. Groups of male Wistar and Sprague-Dawley rats were prepared with intravenous catheters and trained to self-administer 4-MMC in 1-hour sessions. Per-infusion doses of 0.5 and 1.0 mg/kg were consistently self-administered, resulting in greater than 80% discrimination for the drug-paired lever and mean intakes of about 2-3 mg/kg/hour. Dose-substitution studies after acquisition demonstrated that the number of responses and/or the total amount of drug self-administered varied as a function of dose. In addition, radiotelemetry devices were used to show that self-administered 4-MMC was capable of increasing locomotor activity (Wistar) and decreasing body temperature (Sprague-Dawley). Pharmacokinetic studies found that the T1/2 of 4-MMC was about 1 hour in vivo in rat plasma and 90 minutes using in vitro liver microsomal assays. This study provides evidence of stimulant-typical abuse liability for 4-MMC in the traditional pre-clinical self-administration model. PMID:23363010

  14. Ecological risk and resilience perspective: a theoretical framework supporting evidence-based practice in schools.

    Science.gov (United States)

    Powers, Joelle D

    2010-10-01

    Multidisciplinary school practitioners are clearly being called to use evidence-based practices from reputable sources such as their own professional organizations and federal agencies. In spite of this encouragement, most schools are not regularly employing empirically supported interventions. This paper further promotes the use of this approach by describing the theoretical support for evidence-based practice in schools. The ecological risk and resilience theoretical framework presented fills a gap in the literature and advocates for evidence-based practice in schools by illustrating how it can assist practitioners such as school social workers to better address problems associated with school failure. PMID:21082473

  15. Consensus Recommendations for Systematic Evaluation of Drug-Drug Interaction Evidence for Clinical Decision Support

    Science.gov (United States)

    Scheife, Richard T.; Hines, Lisa E.; Boyce, Richard D.; Chung, Sophie P.; Momper, Jeremiah; Sommer, Christine D.; Abernethy, Darrell R.; Horn, John; Sklar, Stephen J.; Wong, Samantha K.; Jones, Gretchen; Brown, Mary; Grizzle, Amy J.; Comes, Susan; Wilkins, Tricia Lee; Borst, Clarissa; Wittie, Michael A.; Rich, Alissa; Malone, Daniel C.

    2015-01-01

    Background Healthcare organizations, compendia, and drug knowledgebase vendors use varying methods to evaluate and synthesize evidence on drug-drug interactions (DDIs). This situation has a negative effect on electronic prescribing and medication information systems that warn clinicians of potentially harmful medication combinations. Objective To provide recommendations for systematic evaluation of evidence from the scientific literature, drug product labeling, and regulatory documents with respect to DDIs for clinical decision support. Methods A conference series was conducted to develop a structured process to improve the quality of DDI alerting systems. Three expert workgroups were assembled to address the goals of the conference. The Evidence Workgroup consisted of 15 individuals with expertise in pharmacology, drug information, biomedical informatics, and clinical decision support. Workgroup members met via webinar from January 2013 to February 2014. Two in-person meetings were conducted in May and September 2013 to reach consensus on recommendations. Results We developed expert-consensus answers to three key questions: 1) What is the best approach to evaluate DDI evidence?; 2) What evidence is required for a DDI to be applicable to an entire class of drugs?; and 3) How should a structured evaluation process be vetted and validated? Conclusion Evidence-based decision support for DDIs requires consistent application of transparent and systematic methods to evaluate the evidence. Drug information systems that implement these recommendations should be able to provide higher quality information about DDIs in drug compendia and clinical decision support tools. PMID:25556085

  16. Implementing administrative evidence based practices: lessons from the field in six local health departments across the United States

    OpenAIRE

    Duggan, Kathleen; Aisaka, Kristelle; Tabak, Rachel G.; Smith, Carson; Erwin, Paul; Brownson, Ross C.

    2015-01-01

    Background Administrative evidence based practices (A-EBPs) are agency level structures and activities positively associated with performance measures (e.g., achieving core public health functions, carrying out evidence-based interventions). The objectives of this study were to examine the contextual conditions and explore differences in local health department (LHD) characteristics that influence the implementation of A-EBPs. Methods Qualitative case studies were conducted based on data from...

  17. Evidence for Status Epilepticus and Pro-Inflammatory Changes after Intranasal Kainic Acid Administration in Mice.

    Directory of Open Access Journals (Sweden)

    Mounira Sabilallah

    Full Text Available Kainic acid (KA is routinely used to elicit status epilepticus (SE and epileptogenesis. Among the available KA administration protocols, intranasal instillation (IN remains understudied. Dosages of KA were instilled IN in mice. Racine Scale and Video-EEG were used to assess and quantify SE onset. Time spent in SE and spike activity was quantified for each animal and confirmed by power spectrum analysis. Immunohistochemistry and qPCR were performed to define brain inflammation occurring after SE, including activated microglial phenotypes. Long term video-EEG recording was also performed. Titration of IN KA showed that a dose of 30 mg/kg was associated with low mortality while eliciting SE. IN KA provoked at least one behavioral and electrographic SE in the majority of the mice (>90%. Behavioral and EEG SE were accompanied by a rapid and persistent microglial-astrocytic cell activation and hippocampal neurodegeneration. Specifically, microglial modifications involved both pro- (M1 and anti-inflammatory (M2 genes. Our initial long-term video-EEG exploration conducted using a small cohort of mice indicated the appearance of spike activity or SE. Our study demonstrated that induction of SE is attainable using IN KA in mice. Typical pro-inflammatory brain changes were observed in this model after SE, supporting disease pathophysiology. Our results are in favor of the further development of IN KA as a means to study seizure disorders. A possibility for tailoring this model to drug testing or to study mechanisms of disease is offered.

  18. Evidence-informed health policy 2 – Survey of organizations that support the use of research evidence

    Directory of Open Access Journals (Sweden)

    Oxman Andrew D

    2008-12-01

    Full Text Available Abstract Background Previous surveys of organizations that support the development of evidence-informed health policies have focused on organizations that produce clinical practice guidelines (CPGs or undertake health technology assessments (HTAs. Only rarely have surveys focused at least in part on units that directly support the use of research evidence in developing health policy on an international, national, and state or provincial level (i.e., government support units, or GSUs that are in some way successful or innovative or that support the use of research evidence in low- and middle-income countries (LMICs. Methods We drew on many people and organizations around the world, including our project reference group, to generate a list of organizations to survey. We modified a questionnaire that had been developed originally by the Appraisal of Guidelines, Research and Evaluation in Europe (AGREE collaboration and adapted one version of the questionnaire for organizations producing CPGs and HTAs, and another for GSUs. We sent the questionnaire by email to 176 organizations and followed up periodically with non-responders by email and telephone. Results We received completed questionnaires from 152 (86% organizations. More than one-half of the organizations (and particularly HTA agencies reported that examples from other countries were helpful in establishing their organization. A higher proportion of GSUs than CPG- or HTA-producing organizations involved target users in the selection of topics or the services undertaken. Most organizations have few (five or fewer full-time equivalent (FTE staff. More than four-fifths of organizations reported providing panels with or using systematic reviews. GSUs tended to use a wide variety of explicit valuation processes for the research evidence, but none with the frequency that organizations producing CPGs, HTAs, or both prioritized evidence by its quality. Between one-half and two-thirds of organizations

  19. Assessing Confidence in Performance Assessments Using an Evidence Support Logic Methodology: An Application of Tesla

    International Nuclear Information System (INIS)

    The assessment of uncertainties and their implications is a key requirement when undertaking performance assessment (PA) of radioactive waste facilities. Decisions based on the outcome of such assessments become translated into judgments about confidence in the information they provide. This confidence, in turn, depends on uncertainties in the underlying evidence. Even if there is a large amount of information supporting an assessment, it may be only partially relevant, incomplete or less than completely reliable. In order to develop a measure of confidence in the outcome, sources of uncertainty need to be identified and adequately addressed in the development of the PA, or in any overarching strategic decision-making processes. This paper describes a trial application of the technique of Evidence Support Logic (ESL), which has been designed for application in support of 'high stakes' decisions, where important aspects of system performance are subject to uncertainty. The aims of ESL are to identify the amount of uncertainty or conflict associated with evidence relating to a particular decision, and to guide understanding of how evidence combines to support confidence in judgments. Elicitation techniques are used to enable participants in the process to develop a logical hypothesis model that best represents the relationships between different sources of evidence to the proposition under examination. The aim is to identify key areas of subjectivity and other sources of potential bias in the use of evidence (whether for or against the proposition) to support judgments of confidence. Propagation algorithms are used to investigate the overall implications of the logic according to the strength of the underlying evidence and associated uncertainties. (authors)

  20. Research-informed evidence and support for road safety legislation: findings from a national survey.

    Science.gov (United States)

    Smith, Katherine Clegg; Debinski, Beata; Pollack, Keshia; Vernick, Jon; Bowman, Stephen; Samuels, Alicia; Gielen, Andrea

    2014-12-01

    Public opinion is influential in the policymaking process, making it important to understand the factors that influence popular support or opposition to public health policies. Researchers and policymakers tend to agree that scientific evidence can inform decision-making, but this influence has not been explored sufficiently, especially in the area of injury prevention. This paper considers the potential for the communication of evidence-based research and public health data to influence opinion about legislation that could reduce road-related injury. We conducted a nationally-representative online survey to assess public attitudes toward four road-safety laws; ignition interlock, school zone red-light cameras, restrictions on infotainment systems, and children's bicycle helmets. For each law, we assessed initial support and then provided a research-informed statistic on either the injury risk posed or the law's efficacy reducing risk and re-examined the law's support or opposition. The survey was completed by 2397 U.S. adults. Each law was initially supported by a majority of respondents, with greatest support for ignition interlock (74.4%) and children's bicycle helmets (74.8%). Exposure to research-informed statements increased legislative support for 20-30% of respondents. Paired analyses demonstrate significant increases toward supportive opinions when comparing responses to the initial and research-informed statements. The study demonstrates considerable public support for evidence-based road-related laws. Overall support was augmented by exposure to research data. Injury prevention practitioners can capitalize on this support in efforts to build support for legislation that would prevent injury. Researchers should be encouraged to expand their efforts to share research results with both the public and policymakers. PMID:25215926

  1. Supporting Evidence-Informed Spatial Planning in Ireland: A Research Perspective

    OpenAIRE

    Walsh, Cormac; Kitchin, Rob

    2012-01-01

    The Irish Planning Institute has recently highlighted the need for ‘coordinated and comprehensive research on planning and development matters at a national level’ to support evidence–based planning in Ireland (President’s address, Autumn Conference 2010). New legislative requirements and a rapidly changing planning and development environment have served to highlight the need for a robust evidence and research base to support decision-making and monitoring at local, regiona...

  2. Brief Report: An Independent Replication and Extension of Psychometric Evidence Supporting the Theory of Mind Inventory

    Science.gov (United States)

    Greenslade, Kathryn J.; Coggins, Truman E.

    2016-01-01

    This study presents an independent replication and extension of psychometric evidence supporting the "Theory of Mind Inventory" ("ToMI"). Parents of 20 children with ASD (4; 1-6; 7 years; months) and 20 with typical development (3; 1-6; 5), rated their child's theory of mind abilities in everyday situations. Other parent report…

  3. Analysis of Evidence Supporting the Educational Leadership Constituent Council 2011 Educational Leadership Program Standards

    Science.gov (United States)

    Tucker, Pamela D.; Anderson, Erin; Reynolds, Amy L.; Mawhinney, Hanne

    2016-01-01

    This document analysis provides a summary of the research from high-impact journals published between 2008 and 2013 with the explicit purpose of determining the extent to which the current empirical evidence supports the individual 2011 Educational Leadership Constituent Council Program Standards and their elements. We found that the standards are…

  4. Barriers to the Use of Evidence-Supported Programs to Address School Violence

    Science.gov (United States)

    Cawood, Natalie Diane

    2010-01-01

    Researchers have argued that there is a research-practice gap in the delivery of prevention and mental health services in the school setting. This national survey addresses that gap by identifying the barriers confronted by school social workers in implementing evidence-supported programs to address interpersonal violence in the school context. A…

  5. Addressing Interpersonal Violence in the School Context: Awareness and Use of Evidence-Supported Programs

    Science.gov (United States)

    Cawood, Natalie Diane

    2013-01-01

    A cross-sectional, Web-based survey was completed by 250 members of the School Social Work Association of America. This article addresses the research-practice gap in the delivery of mental health services in the school setting by examining the extent to which evidence-supported school violence intervention programs (ESPs) are known and used by…

  6. Supporting Graduate Students of Color in Educational Administration Preparation Programs: Faculty Perspectives on Best Practices, Possibilities, and Problems

    Science.gov (United States)

    Young, Michelle D.; Brooks, Jeffrey S.

    2008-01-01

    Overview: This article presents findings from a study that examined faculty perspectives on how individual faculty members and institutions support graduate students of color in educational administration preparation programs. Purpose: The purpose of this study was to identify strategies that faculty members and institutions employ to support…

  7. 78 FR 68030 - Possible Models for the Administration and Support of Discipline-Specific Guidance Groups for...

    Science.gov (United States)

    2013-11-13

    ...-specific guidance groups for Forensic Science (78 FR 59654). That Notice of Inquiry may be found at https... Discipline- Specific Guidance Groups for Forensic Science AGENCY: National Institute of Standards and... Administration and Support of Discipline-Specific Guidance Groups for Forensic Science. Due to the lack...

  8. Social and Student Engagement and Support: The Sloan-C Quality Scorecard for the Administration of Online Programs

    Science.gov (United States)

    Moore, Janet C.; Shelton, Kaye

    2013-01-01

    As combinations of place-based, blended and fully online education proliferate, so do options for support and services. Aligning with regional accreditation criteria, the Sloan-C Quality Scorecard for the Administration of Online Programs is a useful way for institutions to measure and compare the quality of social and student engagement and…

  9. Evidence-informed health policy 4 – Case descriptions of organizations that support the use of research evidence

    Directory of Open Access Journals (Sweden)

    Oxman Andrew D

    2008-12-01

    Full Text Available Abstract Background Previous efforts to produce case descriptions have typically not focused on the organizations that produce research evidence and support its use. External evaluations of such organizations have typically not been analyzed as a group to identify the lessons that have emerged across multiple evaluations. Case descriptions offer the potential for capturing the views and experiences of many individuals who are familiar with an organization, including staff, advocates, and critics. Methods We purposively sampled a subgroup of organizations from among those that participated in the second (interview phase of the study and (once from among other organizations with which we were familiar. We developed and pilot-tested a case description data collection protocol, and conducted site visits that included both interviews and documentary analyses. Themes were identified from among responses to semi-structured questions using a constant comparative method of analysis. We produced both a brief (one to two pages written description and a video documentary for each case. Results We conducted 51 interviews as part of the eight site visits. Two organizational strengths were repeatedly cited by individuals participating in the site visits: use of an evidence-based approach (which was identified as being very time-consuming and existence of a strong relationship between researchers and policymakers (which can be challenged by conflicts of interest. Two organizational weaknesses – a lack of resources and the presence of conflicts of interest – were repeatedly cited by individuals participating in the site visits. Participants offered two main suggestions for the World Health Organization (and other international organizations and networks: 1 mobilize one or more of government support, financial resources, and the participation of both policymakers and researchers; and 2 create knowledge-related global public goods. Conclusion The findings from

  10. Should welfare administration be centralized or decentralized? Evidence from a policy experiment

    OpenAIRE

    Boockmann, Bernhard; Thomsen, Stephan L.; Walter, Thomas; Göbel, Christian; Huber, Martin

    2010-01-01

    The 2005 reform of the German welfare system introduced two competing organizational models for welfare administration. In most districts, a centralized organization was established where local welfare agencies are bound to central directives. At the same time, 69 districts were allowed to opt for a decentralized organization. We evaluate the relative success of both types of organizations. Compared to centralized organization, decentralized organization of welfare administration has a negati...

  11. Intravenous administration of apomorphine does not induce long QT syndrome: Experimental evidence from in vivo canine models

    OpenAIRE

    渡辺, 雄大

    2016-01-01

    主査 : 杉薫 / タイトル : Intravenous administration of apomorphine does not induce long QT syndrome: Experimental evidence from in vivo canine models /著者 : Yudai Watanabe, Yuji Nakamura, Xin Cao, Hiroshi Ohara, Yukiko Yamazaki, Norie Murayama, Yosuke Sugiyama, Hiroko Izumi-Nakaseko, Kentaro Ando, Hiroshi Yamazaki, Atsushi Sugiyama /掲載誌 : Basic & Clinical Pharmacology & Toxicology /巻号・発行年等 : 116 (6):468-475, 2015 /

  12. District Central Office Leadership as Teaching: How Central Office Administrators Support Principals' Development as Instructional Leaders

    Science.gov (United States)

    Honig, Meredith I.

    2012-01-01

    Purpose: Research on educational leadership underscores the importance of principals operating as instructional leaders and intensive job-embedded supports for such work; this research also identifies central office staff as key support providers. However, it teaches little about what central office staff do when they provide such support and how…

  13. Lisfranc injury in the athlete: evidence supporting management from sprain to fracture dislocation.

    Science.gov (United States)

    Eleftheriou, Kyriacos I; Rosenfeld, Peter F

    2013-06-01

    Although Lisfranc injuries are uncommon, prompt and accurate diagnosis of such injuries in athletes is essential in preventing career-ending injury. Undisplaced injuries have an excellent result with nonoperative treatment. The presence of any displacement warrants open reduction and anatomic fixation; although current evidence mostly supports screw fixation, plate fixation may avoid joint intrusion. It is imperative to warn athletes with significantly displaced injuries that there is a risk of a poor outcome, although some recent evidence suggests that return to elite competitive sports is still likely after surgical intervention. Severe injuries may have better outcomes with limited arthrodesis. PMID:23707175

  14. Evidence-informed health policy 3 – Interviews with the directors of organizations that support the use of research evidence

    Directory of Open Access Journals (Sweden)

    Moynihan Ray

    2008-12-01

    Full Text Available Abstract Background Only a small number of previous efforts to describe the experiences of organizations that produce clinical practice guidelines (CPGs, undertake health technology assessments (HTAs, or directly support the use of research evidence in developing health policy (i.e., government support units, or GSUs have relied on interviews and then only with HTA agencies. Interviews offer the potential for capturing experiences in great depth, particularly the experiences of organizations that may be under-represented in surveys. Methods We purposively sampled organizations from among those who completed a questionnaire in the first phase of our three-phase study, developed and piloted a semi-structured interview guide, and conducted the interviews by telephone, audio-taped them, and took notes simultaneously. Binary or categorical responses to more structured questions were counted when possible. Themes were identified from among responses to semi-structured questions using a constant comparative method of analysis. Illustrative quotations were identified to supplement the narrative description of the themes. Results We interviewed the director (or his or her nominee in 25 organizations, of which 12 were GSUs. Using rigorous methods that are systematic and transparent (sometimes shortened to 'being evidence-based' was the most commonly cited strength among all organizations. GSUs more consistently described their close links with policymakers as a strength, whereas organizations producing CPGs, HTAs, or both had conflicting viewpoints about such close links. With few exceptions, all types of organizations tended to focus largely on weaknesses in implementation, rather than strengths. The advice offered to those trying to establish similar organizations include: 1 collaborate with other organizations; 2 establish strong links with policymakers and stakeholders; 3 be independent and manage conflicts of interest; 4 build capacity; 5 use good

  15. The evidence of neuraxial administration of analgesics for cancer-related pain

    DEFF Research Database (Denmark)

    Kurita, G P; Benthien, K S; Nordly, M;

    2015-01-01

    retrieved was 2147, and 84 articles were selected for full reading. The final selection comprised nine articles regarding randomised controlled trials (RCTs) divided in four groups: neuraxial combinations of opioid and adjuvant analgesic compared with neuraxial administration of opioid alone (n = 4); single...... neuraxial drug in bolus compared with continuous administration (n = 2); single neuraxial drug compared with neuraxial placebo (n = 1); and neuraxial opioid combined with or without adjuvant analgesic compared with other comprehensive medical management than neuraxial analgesics (n = 2). The RCTs presented...

  16. Using the Substance Abuse and Mental Health Services Administration (SAMHSA) Evidence-Based Practice Kits in Social Work Education

    Science.gov (United States)

    Myers, Laura L.; Wodarski, John S.

    2014-01-01

    In today's climate, it is becoming increasingly important to provide social work students with practice knowledge on research-supported social work interventions. CSWE has placed greater emphasis on using research-based knowledge to inform and guide social work practice, and the field has recognized the value of adhering to the evidence-based…

  17. Multiple Lines Of Evidence Supporting Natural Attenuation: Lines Of Inquiry Supporting Monitored Natural Attenuation And Enhanced Attenuatin Of Chlorinated Solvents

    Energy Technology Data Exchange (ETDEWEB)

    Vangelas, Karen; Widemeirer, T. H.; Barden, M.J.; Dickson, W. Z.; Major, David

    2004-12-31

    The Department of Energy (DOE) is sponsoring an initiative to facilitate efficient, effective and responsible use of Monitored Natural Attenuation (MNA) and Enhanced Attenuation (EA) for chlorinated solvents. This Office of Environmental Management (EM) ''Alternative Project,'' focuses on providing scientific and policy support for MNA/EA. A broadly representative working group of scientists supports the project along with partnerships with regulatory organizations such as the Interstate Technology Regulatory Council (ITRC) and the United States Environmental Protection Agency (USEPA). The initial product of the technical working group was a summary report that articulated the conceptual approach and central scientific tenants of the project, and that identified a prioritized listing of technical targets for field research. This report documented the process in which: (1) scientific ground rules were developed, (2) lines of inquiry were identified and then critically evaluated, (3) promising applied research topics were highlighted in the various lines of inquiry, and (4) these were discussed and prioritized. The summary report will serve as a resource to guide management and decision making throughout the period of the subject MNA/EA Alternative Project. To support and more fully document the information presented in the summary report, the DOE is publishing a series of supplemental documents that present the full texts from the technical analyses within the various lines of inquiry (see listing). The following report--documenting our evaluation of the state of the science for the lines of evidence for supporting decision-making for MNA--is one of those supplemental documents.

  18. 77 FR 72691 - Small Business Size Standards: Administrative and Support, Waste Management and Remediation Services

    Science.gov (United States)

    2012-12-06

    ... Management and Remediation Services AGENCY: U.S. Small Business Administration. ACTION: Final rule. SUMMARY... inflation adjustment to size standards was published in the Federal Register on July 18, 2008 (73 FR 41237... (76 FR 63510) seeking public comment on its proposal to increase the size standards for 37...

  19. The Documentation Process: The Administrator's Role and the Interplay of Necessity, Support and Collaboration

    Science.gov (United States)

    Charlton, Donna; Kritsonis, William Allan

    2008-01-01

    Traditional teacher documentation procedures pit the administrator against the teacher. The process is adversarial and erodes the quality of the intervention. Teachers who are unsuccessful in meeting campus/school district expectations can be successfully acclimatized to the campus culture through a documentation process that combines affective…

  20. How To Gain Support from Your Board and Administration: Marketing 101 for Your Library Media Program.

    Science.gov (United States)

    Baule, Steven M.; Bertani, Laura Blair

    2000-01-01

    Discusses the importance of marketing library media programs to school boards and school district administrators. Suggests aligning library goals with district goals; hosting district board meetings; designing flyers to promote library services; developing library newsletters; annual reports that highlights achievements; networking; formal…

  1. Additional Interventions to Enhance the Effectiveness of Individual Placement and Support: A Rapid Evidence Assessment

    Directory of Open Access Journals (Sweden)

    Naomi Boycott

    2012-01-01

    Full Text Available Topic. Additional interventions used to enhance the effectiveness of individual placement and support (IPS. Aim. To establish whether additional interventions improve the vocational outcomes of IPS alone for people with severe mental illness. Method. A rapid evidence assessment of the literature was conducted for studies where behavioural or psychological interventions have been used to supplement standard IPS. Published and unpublished empirical studies of IPS with additional interventions were considered for inclusion. Conclusions. Six published studies were found which compared IPS alone to IPS plus a supplementary intervention. Of these, three used skills training and three used cognitive remediation. The contribution of each discrete intervention is difficult to establish. Some evidence suggests that work-related social skills and cognitive training are effective adjuncts, but this is an area where large RCTs are required to yield conclusive evidence.

  2. iRefWeb: interactive analysis of consolidated protein interaction data and their supporting evidence

    OpenAIRE

    Turner, Brian; Razick, Sabry; Turinsky, Andrei L.; Vlasblom, James; Crowdy, Edgard K.; Cho, Emerson; Morrison, Kyle; Donaldson, Ian M; Wodak, Shoshana J.

    2010-01-01

    We present iRefWeb, a web interface to protein interaction data consolidated from 10 public databases: BIND, BioGRID, CORUM, DIP, IntAct, HPRD, MINT, MPact, MPPI and OPHID. iRefWeb enables users to examine aggregated interactions for a protein of interest, and presents various statistical summaries of the data across databases, such as the number of organism-specific interactions, proteins and cited publications. Through links to source databases and supporting evidence, researchers may gauge...

  3. [Evidence in support of Florence Nightingale's theories. 100 years after her death].

    Science.gov (United States)

    Zapico Yáñez, Florentina

    2010-05-01

    This article has been written to pay homage to Florence Nightingale as a pioneer and beacon for scientific curiosity which should serve as the nursing professional's guide for fine praxis. For this purpose, the author studied the evidence regarding Ms Nightingale's supposed theories; these have been arranged into four large groups in order to make those findings which support her theories easier to understand. PMID:20617658

  4. Economic Impact of Support Service Program on Micro and Small Enterprises: The Case of Dire Dawa Administration, Ethiopia

    Directory of Open Access Journals (Sweden)

    B. Kassa

    2013-03-01

    Full Text Available Special attention has been given to untie the constraints of Micro and Small Enterprises in Ethiopia for they are important vehicles to address the challenges of unemployment, economic growth and equity in the country. The government is implementing different support service programs, in the forms of financial and business development, in different parts of the country. This study is aimed at evaluating economic impact of MSEs support service programs on enterprise sales, employment and capital asset formation in Dire Dawa Administration, Ethiopia. Propensity Score Matching is employed to estimate the impact of support service program. The result revealed that the program resulted in average increment of monthly sales by 28%, employee level by 42%, and capital asset formation by 60%. It is, therefore, indispensable to strengthen and expand the support service program to non participant enterprises by giving special attention to the major problems that participant enterprises are currently facing.

  5. A study conducted on the demographic factors of victims of violence in support and administrative departments of hospital in 2013

    OpenAIRE

    Keyvanara, Mahmoud; Maracy, Mohammad Reza; Ziari, Najmeh Bahman

    2015-01-01

    Background: Violence is now regarded as a serious problem and its complication causes heavy costs on the healthcare systems. The present study aimed to investigate the correlation between some demographic characteristics and confrontation with violence. Since there is no study on the prevalence of violence among the support and administration staff of hospitals in Iran, this study was conducted to investigate violence in these departments. Materials and Methods: This descriptive–analytical an...

  6. Administrators, Faculty, and Staff/Support Staff Perceptions of MBNQA Educational Criteria Implementation at the University of Wisconsin Stout

    OpenAIRE

    Dettmann, Paul E.

    2004-01-01

    This study focused on the University of Wisconsin Stout's (UW Stout) implementation of the Malcolm Baldridge Award (MBNQA) Criteria for Educational Performance Excellence. The study had two objectives: (1) to determine administrator, faculty, and staff/support staff perceptions and compare those perceptions; and, (2) to identify the positive and negative views each of the three groups held regarding the implementation process. The study design was a mixed method approach which used both qua...

  7. Determining the Administrative Support and Professional Development Needs of Contract Instructors at a Civilian Federal Training Agency.

    OpenAIRE

    Saitta, Joseph V. Jr.

    1998-01-01

    Researchers know much about the use of contract (or adjunct) instructor faculty in academe, but little about contract instructors in civilian federal training agencies. No one has determined the effective administrative support of instructional delivery or the professional development needs of these federal agency contractors. The National Fire Academy's mission is to promote the professional development of those fire personnel engaged in fire suppression, fire prevention, and allied funct...

  8. Should Welfare Administration be Centralized or Decentralized? Evidence from a Policy Experiment

    OpenAIRE

    Huber, Martin

    2014-01-01

    The 2005 reform of the German welfare system introduced two competing organizational models for welfare administration. In most districts, a centralized organization was established where local welfare agencies are bound to central directives. At the same time, 69 districts were allowed to opt for a decentralized organization. We evaluate the relative success of both types in terms of integrating welfare recipients into employment. Com-pared to centralized organization, decentralized organiza...

  9. Will mass drug administration eliminate lymphatic filariasis? Evidence from northern coastal Tanzania

    OpenAIRE

    Parker, M.; Allen, T.

    2012-01-01

    Summary This article documents understandings and responses to mass drug administration (MDA) for the treatment and prevention of lymphatic filariasis among adults and children in northern coastal Tanzania from 2004 to 2011. Assessment of village-level distribution registers, combined with self-reported drug uptake surveys of adults, participant observation and interviews, revealed that at study sites in Pangani and Muheza districts the uptake of drugs was persistently low. The majority of pe...

  10. (Un)Informed College and Major Choice: Evidence from Linked Survey and Administrative Data

    OpenAIRE

    Hastings, Justine S.; Christopher A. Neilson; Anely Ramirez; Seth D. Zimmerman

    2015-01-01

    We use large-scale surveys of Chilean college applicants and college students to explore the way students form beliefs about earnings and cost outcomes at different institutions and majors and how these beliefs relate to degree choice and persistence. Linking our survey records to administrative education and earnings data, we compare earnings and cost expectations to observed values for past students and follow survey participants forward to see how beliefs relate to matriculation and dropou...

  11. Social Validation of Evidence-Based Practices in Autism by Parents, Teachers, and Administrators

    Science.gov (United States)

    Callahan, Kevin; Henson, Robin K.; Cowan, Angela K.

    2008-01-01

    Relatively little attention has been devoted to the social validation of potentially effective autism interventions. Thus, it is often difficult to identify and implement evidence-based practices, and programming is often inadequate. The authors identified autism intervention components with reported effectiveness for school settings. The results…

  12. Job Loss, Firm-Level Heterogeneity and Mortality: Evidence from Administrative Data

    OpenAIRE

    Bloemen, Hans; Hochguertel, Stefan; Zweerink, Jochem

    2015-01-01

    This paper estimates the effect of job loss on mortality for older male workers with strong labor force attachment. Using Dutch administrative data, we find that job loss due to sudden firm closure increased the probability to die within five years by a sizable 0.60 percentage points. Importantly, this effect is estimated using a model that controls for firm‐level worker characteristics, such as firm‐level average mortality rates for mortality during the four years prior to the year of observ...

  13. Towards sustainable systems of land administration: Recent evidence and challenges for Africa

    OpenAIRE

    Deininger, Klaus

    2010-01-01

    A number of factors, including a recent rediscovery of the agricultural sector, growing demands for large-scale land acquisition, and economic growth, have increased demand for land registration in Africa. On the basis of a review of evidence, we argue that, in most cases, a key benefit from such interventions will be greater tenure security and the associated investment or rental market participation rather than credit effects. Interventions to formalize rights in the African context need to...

  14. Intravenous administration of apomorphine does not induce long QT syndrome: Experimental evidence from in vivo canine models

    OpenAIRE

    渡辺, 雄大

    2016-01-01

    主査 : 杉薫 / タイトル : Intravenous administration of apomorphine does not induce long QT syndrome: Experimental evidence from in vivo canine models /著者 : Yudai Watanabe, Yuji Nakamura, Xin Cao, Hiroshi Ohara, Yukiko Yamazaki, Norie Murayama, Yosuke Sugiyama, Hiroko Izumi-Nakaseko, Kentaro Ando, Hiroshi Yamazaki, Atsushi Sugiyama /掲載誌 : Basic & Clinical Pharmacology & Toxicology /巻号・発行年等 : 116 (6):468-475, 2015 /本文ファイル: 査読後原稿 /This is the peer reviewed version of the following article:Basic & Clinic...

  15. Cancer Multidisciplinary Team Meetings: Evidence, Challenges, and the Role of Clinical Decision Support Technology

    International Nuclear Information System (INIS)

    Multidisciplinary team (MDT) model in cancer care was introduced and endorsed to ensure that care delivery is consistent with the best available evidence. Over the last few years, regular MDT meetings have become a standard practice in oncology and gained the status of the key decision-making forum for patient management. Despite the fact that cancer MDT meetings are well accepted by clinicians, concerns are raised over the paucity of good-quality evidence on their overall impact. There are also concerns over lack of the appropriate support for this important but overburdened decision-making platform. The growing acceptance by clinical community of the health information technology in recent years has created new opportunities and possibilities of using advanced clinical decision support (CDS) systems to realise full potential of cancer MDT meetings. In this paper, we present targeted summary of the available evidence on the impact of cancer MDT meetings, discuss the reported challenges, and explore the role that a CDS technology could play in addressing some of these challenges

  16. 44 CFR 11.14 - Administrative claim; evidence and information to be submitted.

    Science.gov (United States)

    2010-10-01

    ..., including his or her monthly or yearly salary or earnings (if any), and the duration of his or her last... salary actually lost. (5) If a claim is made for loss of income and the claimant is self-employed... damages claimed. (c) Property damage. In support of a claim for injury to or loss of property, real...

  17. Legal and administrative structure to provide support for an effective state system of accounting and control

    International Nuclear Information System (INIS)

    The need for, and the form of, suitable legislative support for a State System of Accounting and Control are discussed. The Australian experience in giving legal effect to its IAEA Safeguards Agreement is described. The functions of the competent national authority and the appropriate place for it in the government structure are outlined

  18. Ocean Acidification and the End-Permian Mass Extinction: To What Extent does Evidence Support Hypothesis?

    Directory of Open Access Journals (Sweden)

    Marie-Béatrice Forel

    2012-09-01

    Full Text Available Ocean acidification in modern oceans is linked to rapid increase in atmospheric CO2, raising concern about marine diversity, food security and ecosystem services. Proxy evidence for acidification during past crises may help predict future change, but three issues limit confidence of comparisons between modern and ancient ocean acidification, illustrated from the end-Permian extinction, 252 million years ago: (1 problems with evidence for ocean acidification preserved in sedimentary rocks, where proposed marine dissolution surfaces may be subaerial. Sedimentary evidence that the extinction was partly due to ocean acidification is therefore inconclusive; (2 Fossils of marine animals potentially affected by ocean acidification are imperfect records of past conditions; selective extinction of hypercalcifying organisms is uncertain evidence for acidification; (3 The current high rates of acidification may not reflect past rates, which cannot be measured directly, and whose temporal resolution decreases in older rocks. Thus large increases in CO2 in the past may have occurred over a long enough time to have allowed assimilation into the oceans, and acidification may not have stressed ocean biota to the present extent. Although we acknowledge the very likely occurrence of past ocean acidification, obtaining support presents a continuing challenge for the Earth science community.

  19. Electronic Administration Styles and Their Determinants. Evidence from Spanish Local Governments

    Directory of Open Access Journals (Sweden)

    José Valeriano FRÍAS-ACEITUNO

    2014-02-01

    Full Text Available This paper analyzes the factors underlying the development of e-government, as an overall process, as well as of each of the three stages identified in the prior literature (e-government, egovernance and e-democracy. The analysis has focused on 102 Spanish municipalities, and it consists in a content analysis of their web pages, based on an information index, in order to develop a dependency model. The results obtained indicate that Spanish municipalities show high information transparency regarding economic, environmental and social matters, allowing the undertaking of administrative proceedings online and actively promoting the participation of interest groups in strategic, sustainable and managerial issues. Our findings stress the importance of the municipality’s size and the ruling party’s political ideology of a deeper commitment with the development of e-government.

  20. Evaluating the Development of Virtual Communities of Practice that Support Evidence Based Practice

    Directory of Open Access Journals (Sweden)

    Siân Spink

    2010-03-01

    Full Text Available Objective – The aim of this paper is to examine how virtual community of practice principles might be used by information professionals with emphasis on the work of the Specialist Libraries for health professionals in England, UK. An evaluation conducted in 2004‐2005 examined the operation of the Specialist Libraries, which the National Library for Health had contracted out to various organisations, and assessed their stage of development as communities of practice.Methods – Evaluation methods included observation of a meeting of information specialists, interviews with clinical leads and information specialists, and evaluation of the content and format of the Specialist Library websites. The evaluation framework was based on a systematic review of the literature to determine the critical success factors for communities of practice and their role in supporting evidence based practice. An updated literature review was conducted for this paper.Results – Operational structures varied but were mostly effective in producing communities of practice that were at an “engaged” stage. Some Specialist Libraries wished to move towards the “active” stage by supporting online discussion forums, or by providing question and answering services or more learning activities and materials. Although the evidence from the literature suggests there are few clear criteria for judging the effectiveness of communities of practice, the evaluation framework used here was successful in identifying the state of progress and how information professionals might approach designing virtual communities of practice.Conclusions – Structuring library and information services around community of practice principles is effective. Careful and participative design of the information architecture is required for good support for evidence based practice.

  1. Levers supporting program evaluation culture and capacity in Romanian public administration: The role of leadership

    OpenAIRE

    Cristina Mora; Raluca Antonie (GÂRBOAN)

    2012-01-01

    Program evaluation culture and capacity is at the very beginning of its development in Romania. In this article we highlight one of the fundamental, but not always obvious, connections that support sustainable evaluation culture and capacity building and development: the link between leadership and program evaluation. If properly used, program evaluation results can be a strong instrument in leadership, just as leadership can fundamentally encourage the development of evaluation culture and c...

  2. Force That Increases at Larger Distance Has Some Psychological and Astronomical Evidence Supporting its Existence

    Science.gov (United States)

    Struck, James

    2011-09-01

    Force that Increases with distance is different than dark energy as I am arguing for existence of force based on psychological and astronomical bases. Hubble shift, doppler shift, comet return, quasar zoo and quasars and psychological evidence of interest in distant objects lends support to a force like gravity, nuclear, weak, strong, virtual, decay, biological, growth forces which increases its intensity with distance unlike gravity which decreases in intensity with distance. Jane Frances Back Struck contributed to this finding with her request that her grandparents have "perfect justice" even though her grandparents had died before she was born; interest increasing with distance from grandparents.

  3. Evidence does not support absorption of intact solid lipid nanoparticles via oral delivery

    Science.gov (United States)

    Hu, Xiongwei; Fan, Wufa; Yu, Zhou; Lu, Yi; Qi, Jianping; Zhang, Jian; Dong, Xiaochun; Zhao, Weili; Wu, Wei

    2016-03-01

    Whether and to what extent solid lipid nanoparticles (SLNs) can be absorbed integrally via oral delivery should be clarified because it is the basis for elucidation of absorption mechanisms. To address this topic, the in vivo fate of SLNs as well as their interaction with biomembranes is investigated using water-quenching fluorescent probes that can signal structural variations of lipid-based nanocarriers. Live imaging indicates prolonged retention of SLNs in the stomach, whereas in the intestine, SLNs can be digested quickly. No translocation of intact SLNs to other organs or tissues can be observed. The in situ perfusion study shows bioadhesion of both SLNs and simulated mixed micelles (SMMs) to intestinal mucus, but no evidence of penetration of integral nanocarriers. Both SLNs and SMMs exhibit significant cellular uptake, but fail to penetrate cell monolayers. Confocal laser scanning microscopy reveals that nanocarriers mainly concentrate on the surface of the monolayers, and no evidence of penetration of intact vehicles can be obtained. The mucous layer acts as a barrier to the penetration of both SLNs and SMMs. Both bile salt-decoration and SMM formulation help to strengthen the interaction with biomembranes. It is concluded that evidence does not support absorption of intact SLNs via oral delivery.Whether and to what extent solid lipid nanoparticles (SLNs) can be absorbed integrally via oral delivery should be clarified because it is the basis for elucidation of absorption mechanisms. To address this topic, the in vivo fate of SLNs as well as their interaction with biomembranes is investigated using water-quenching fluorescent probes that can signal structural variations of lipid-based nanocarriers. Live imaging indicates prolonged retention of SLNs in the stomach, whereas in the intestine, SLNs can be digested quickly. No translocation of intact SLNs to other organs or tissues can be observed. The in situ perfusion study shows bioadhesion of both SLNs and

  4. Food and Drug Administration process validation activities to support 99Mo production at Sandia National Laboratories

    Energy Technology Data Exchange (ETDEWEB)

    McDonald, M.J.; Bourcier, S.C.; Talley, D.G.

    1997-07-01

    Prior to 1989 {sup 99}Mo was produced in the US by a single supplier, Cintichem Inc., Tuxedo, NY. Because of problems associated with operating its facility, in 1989 Cintichem elected to decommission the facility rather than incur the costs for repair. The demise of the {sup 99}Mo capability at Cintichem left the US totally reliant upon a single foreign source, Nordion International, located in Ottawa Canada. In 1992 the DOE purchased the Cintichem {sup 99}Mo Production Process and Drug Master File (DMF). In 1994 the DOE funded Sandia National Laboratories (SNL) to produce {sup 99}Mo. Although Cintichem produced {sup 99}Mo and {sup 99m}Tc generators for many years, there was no requirement for process validation which is now required by the Food and Drug Administration (FDA). In addition to the validation requirement, the requirements for current Good manufacturing Practices were codified into law. The purpose of this paper is to describe the process validation being conducted at SNL for the qualification of SNL as a supplier of {sup 99}Mo to US pharmaceutical companies.

  5. Food and Drug Administration process validation activities to support 99Mo production at Sandia National Laboratories

    International Nuclear Information System (INIS)

    Prior to 1989 99Mo was produced in the US by a single supplier, Cintichem Inc., Tuxedo, NY. Because of problems associated with operating its facility, in 1989 Cintichem elected to decommission the facility rather than incur the costs for repair. The demise of the 99Mo capability at Cintichem left the US totally reliant upon a single foreign source, Nordion International, located in Ottawa Canada. In 1992 the DOE purchased the Cintichem 99Mo Production Process and Drug Master File (DMF). In 1994 the DOE funded Sandia National Laboratories (SNL) to produce 99Mo. Although Cintichem produced 99Mo and 99mTc generators for many years, there was no requirement for process validation which is now required by the Food and Drug Administration (FDA). In addition to the validation requirement, the requirements for current Good manufacturing Practices were codified into law. The purpose of this paper is to describe the process validation being conducted at SNL for the qualification of SNL as a supplier of 99Mo to US pharmaceutical companies

  6. No evidence of nanodiamonds in Younger–Dryas sediments to support an impact event

    Science.gov (United States)

    Daulton, Tyrone L.; Pinter, Nicholas; Scott, Andrew C.

    2010-01-01

    The causes of the late Pleistocene megafaunal extinctions in North America, disappearance of Clovis paleoindian lithic technology, and abrupt Younger–Dryas (YD) climate reversal of the last deglacial warming in the Northern Hemisphere remain an enigma. A controversial hypothesis proposes that one or more cometary airbursts/impacts barraged North America ≈12,900 cal yr B.P. and caused these events. Most evidence supporting this hypothesis has been discredited except for reports of nanodiamonds (including the rare hexagonal polytype) in Bølling–Ållerod-YD-boundary sediments. The hexagonal polytype of diamond, lonsdaleite, is of particular interest because it is often associated with shock pressures related to impacts where it has been found to occur naturally. Unfortunately, previous reports of YD-boundary nanodiamonds have left many unanswered questions regarding the nature and occurrence of the nanodiamonds. Therefore, we examined carbon-rich materials isolated from sediments dated 15,818 cal yr B.P. to present (including the Bølling–Ållerod-YD boundary). No nanodiamonds were found in our study. Instead, graphene- and graphene/graphane-oxide aggregates are ubiquitous in all specimens examined. We demonstrate that previous studies misidentified graphene/graphane-oxide aggregates as hexagonal diamond and likely misidentified graphene as cubic diamond. Our results cast doubt upon one of the last widely discussed pieces of evidence supporting the YD impact hypothesis. PMID:20805511

  7. No evidence of nanodiamonds in Younger-Dryas sediments to support an impact event.

    Science.gov (United States)

    Daulton, Tyrone L; Pinter, Nicholas; Scott, Andrew C

    2010-09-14

    The causes of the late Pleistocene megafaunal extinctions in North America, disappearance of Clovis paleoindian lithic technology, and abrupt Younger-Dryas (YD) climate reversal of the last deglacial warming in the Northern Hemisphere remain an enigma. A controversial hypothesis proposes that one or more cometary airbursts/impacts barraged North America ≈12,900 cal yr B.P. and caused these events. Most evidence supporting this hypothesis has been discredited except for reports of nanodiamonds (including the rare hexagonal polytype) in Bølling-Ållerod-YD-boundary sediments. The hexagonal polytype of diamond, lonsdaleite, is of particular interest because it is often associated with shock pressures related to impacts where it has been found to occur naturally. Unfortunately, previous reports of YD-boundary nanodiamonds have left many unanswered questions regarding the nature and occurrence of the nanodiamonds. Therefore, we examined carbon-rich materials isolated from sediments dated 15,818 cal yr B.P. to present (including the Bølling-Allerod-YD boundary). No nanodiamonds were found in our study. Instead, graphene- and graphene/graphane-oxide aggregates are ubiquitous in all specimens examined. We demonstrate that previous studies misidentified graphene/graphane-oxide aggregates as hexagonal diamond and likely misidentified graphene as cubic diamond. Our results cast doubt upon one of the last widely discussed pieces of evidence supporting the YD impact hypothesis. PMID:20805511

  8. What evidence supports special processing for faces? A cautionary tale for fMRI interpretation.

    Science.gov (United States)

    Cowell, Rosemary A; Cottrell, Garrison W

    2013-11-01

    We trained a neurocomputational model on six categories of photographic images that were used in a previous fMRI study of object and face processing. Multivariate pattern analyses of the activations elicited in the object-encoding layer of the model yielded results consistent with two previous, contradictory fMRI studies. Findings from one of the studies [Haxby, J. V., Gobbini, M. I., Furey, M. L., Ishai, A., Schouten, J. L., & Pietrini, P. Distributed and overlapping representations of faces and objects in ventral temporal cortex. Science, 293, 2425-2430, 2001] were interpreted as evidence for the object-form topography model. Findings from the other study [Spiridon, M., & Kanwisher, N. How distributed is visual category information in human occipito-temporal cortex? An fMRI study. Neuron, 35, 1157-1165, 2002] were interpreted as evidence for neural processing mechanisms in the fusiform face area that are specialized for faces. Because the model contains no special processing mechanism or specialized architecture for faces and yet it can reproduce the fMRI findings used to support the claim that there are specialized face-processing neurons, we argue that these fMRI results do not actually support that claim. Results from our neurocomputational model therefore constitute a cautionary tale for the interpretation of fMRI data. PMID:23859648

  9. Extracting physician group intelligence from electronic health records to support evidence based medicine.

    Directory of Open Access Journals (Sweden)

    Griffin M Weber

    Full Text Available Evidence-based medicine employs expert opinion and clinical data to inform clinical decision making. The objective of this study is to determine whether it is possible to complement these sources of evidence with information about physician "group intelligence" that exists in electronic health records. Specifically, we measured laboratory test "repeat intervals", defined as the amount of time it takes for a physician to repeat a test that was previously ordered for the same patient. Our assumption is that while the result of a test is a direct measure of one marker of a patient's health, the physician's decision to order the test is based on multiple factors including past experience, available treatment options, and information about the patient that might not be coded in the electronic health record. By examining repeat intervals in aggregate over large numbers of patients, we show that it is possible to 1 determine what laboratory test results physicians consider "normal", 2 identify subpopulations of patients that deviate from the norm, and 3 identify situations where laboratory tests are over-ordered. We used laboratory tests as just one example of how physician group intelligence can be used to support evidence based medicine in a way that is automated and continually updated.

  10. Intravenous administration of achyranthes bidentata polypeptides supports recovery from experimental ischemic stroke in vivo.

    Directory of Open Access Journals (Sweden)

    Hongmei Shen

    Full Text Available BACKGROUND: Achyranthes bidentata Blume (A. bidentata is a commonly prescribed Chinese medicinal herb. A. bidentata polypeptides (ABPP is an active composite constituent, separated from the aqueous extract of A. bidentata. Our previous studies have found that ABPP have the neuroprotective function in vitro and in rat middle cerebral artery occlusion (MCAO model in attenuating the brain infract area induced by focal ischemia-reperfusion. However, the ultimate goal of the stroke treatment is the restoration of behavioral function. Identifying behavioral deficits and therapeutic treatments in animal models of ischemic stroke is essential for potential translational applications. METHODOLOGY AND PRINCIPAL FINDINGS: The effect of ABPP on motor, sensory, and cognitive function in an ischemic stroke model with MCAO was investigated up to day 30. The function recovery monitored by the neurological deficit score, grip test, body asymmetry, beam-balancing task, and the Morris Water Maze. In this study, systemic administration of ABPP by i.v after MCAO decreased the neurological deficit score, ameliorated the forepaw muscle strength, and diminished the motor and sensory asymmetry on 7(th and 30(th day after MCAO. MCAO has been observed to cause prolonged disturbance of spatial learning and memory in rats using the MWM, and ABPP treatment could improve the spatial learning and memory function, which is impaired by MCAO in rats, on 30(th day after MCAO. Then, the viable cells in CA1 region of hippocampus were counted by Nissl staining, and the neuronal cell death were significantly suppressed in the ABPP treated group. CONCLUSION: ABPP could improve the recovery of sensory, motor and coordination, and cognitive function in MCAO-induced ischemic rats. And this recovery had a good correlation to the less of neuronal injury in brain.

  11. Development of support system for maintenance and administration of reprocessing plant equipment

    International Nuclear Information System (INIS)

    Each year, maintenance work is carried out for about 10,000 pieces of equipment, including mechanical devices, electric equipment and instruments, at the Tokai Reprocessing Plant. Ninety percent of such maintenance work is preventive maintenance. In order to manage the information about the maintenance work, a computer support system was developed between 1985 and 1992. Twenty-seven thousand pieces of equipment and 180,000 maintenance histories have already been registered in the system. The system has been used for planning inspections and replacement of equipment as well as checking their maintenance histories. Actual usage of the system has shown that some auxiliary functions need to be added. The system will therefore be improved and extended. (author)

  12. Current evidence does not support the use of Kinesio Taping in clinical practice: a systematic review

    Directory of Open Access Journals (Sweden)

    Patrícia do Carmo Silva Parreira

    2014-03-01

    Full Text Available Questions: Is Kinesio Taping more effective than a sham taping/placebo, no treatment or other interventions in people with musculoskeletal conditions? Is the addition of Kinesio Taping to other interventions more effective than other interventions alone in people with musculoskeletal conditions? Design: Systematic review of randomised trials. Participants: People with musculoskeletal conditions. Intervention: Kinesio Taping was compared with sham taping/placebo, no treatment, exercises, manual therapy and conventional physiotherapy. Outcome measures: Pain intensity, disability, quality of life, return to work, and global impression of recovery. Results: Twelve randomised trials involving 495 participants were included in the review. The effectiveness of the Kinesio Taping was tested in participants with: shoulder pain in two trials; knee pain in three trials; chronic low back pain in two trials; neck pain in three trials; plantar fasciitis in one trial; and multiple musculoskeletal conditions in one trial. The methodological quality of eligible trials was moderate, with a mean of 6.1 points on the 10-point PEDro Scale score. Overall, Kinesio Taping was no better than sham taping/placebo and active comparison groups. In all comparisons where Kinesio Taping was better than an active or a sham control group, the effect sizes were small and probably not clinically significant or the trials were of low quality. Conclusion: This review provides the most updated evidence on the effectiveness of the Kinesio Taping for musculoskeletal conditions. The current evidence does not support the use of this intervention in these clinical populations. PROSPERO registration: CRD42012003436. [Parreira PdCS, Costa LdCM, Hespanhol Junior LC, Lopes AD, Costa LOP (2014 Current evidence does not support the use of Kinesio Taping in clinical practice: a systematic review. Journal of Physiotherapy 60: 31–39

  13. A critical review of Early Supported Discharge for stroke patients: from evidence to implementation into practice.

    Science.gov (United States)

    Mas, Miquel Àngel; Inzitari, Marco

    2015-01-01

    After an acute stroke, a multidimensional approach based on multidisciplinary work and rehabilitation is required in order to promote functional independence and social reinsertion and to maintain medical stability. These activities are usually developed in the hospital setting as a continuum of the acute phase, but hospitalization is resource consuming and resources are limited. Early Support Discharge strategies base postacute care and rehabilitation at home after an early discharge planning and represent possible alternatives to conventional hospitalization. Recent evidence suggests that Early Supported Discharge might be superior to hospitalization from both the clinical-functional and the economic viewpoints. Moreover, home-based rehabilitation might potentiate important determinants of effectiveness, such as patient's motivation and goal-directed rehabilitation. However, hitherto produced evidence and recommendations show a number of limitations related to the organization models, the inclusion/exclusion criteria, and the questionable applicability of results to any healthcare setting worldwide. In this article, we critically review different methodological and organizational aspects of the available studies. For example in the definition of the target population, based mainly on residual disability and medical stability, we suggest that other relevant aspects, such as premorbid functional status, cognitive function, and previous institutionalization, should be better defined. Focusing on the outcomes, we suggest that, besides strong outcomes such as global functioning, surrogate outcomes, such as physical function, could help to refine the specific interventions. Finally, considering that the majority of studies were conducted in northern Europe, further studies are needed to test the implementation of Early Supported Discharge in different regions. PMID:23227916

  14. Space-time clustering of childhood leukaemia in Greece: evidence supporting a viral aetiology.

    Science.gov (United States)

    Petridou, E.; Revinthi, K.; Alexander, F. E.; Haidas, S.; Koliouskas, D.; Kosmidis, H.; Piperopoulou, F.; Tzortzatou, F.; Trichopoulos, D.

    1996-01-01

    The method introduced by Knox for evaluation of space-time clustering has been applied to 872 cases of childhood (0-14 year old) leukaemia diagnosed in Greece over the 10 year period 1980-89. Greek towns are characterised by substantial population mixing due to internal migration, whereas there is relative isolation in mountainous rural areas. Predetermined space (5 km) and time (1 year) limits were used on the basis of previous reports in order to define the clustering cell. There is highly significant evidence for clustering of childhood leukaemia in Greece as a whole, the observed number of pairs that are close in both spaces and time exceeding the expected number by 5.2% (P = 0.004). The excess is particularly evident for leukaemia cases in 0 to 4-year-old children, among whom the observed number of pairs that are close in both space and time exceeded the expected number by 9.4% (P = 0.004). There is no evidence of space-time clustering for leukaemia cases older than 5 years. The overall pattern is descriptively similar in urban and semiurban areas and is especially marked for acute lymphoblastic leukaemia at the childhood peak ages (2-4 years) with an excess of 19% (P = 0.0006). In the rural population there is evidence for clustering of cases belonging to older and broader age groups, a phenomenon compatible with a delay in the development of herd immunity against putative infectious aetiological agents. The findings of the present study provide support for the hypothesis that a substantial proportion of cases of childhood leukaemia may arise as a rare sequel to exposure to an agent or agents, most probably viral in nature. PMID:8630293

  15. The Significance of Ongoing Teacher Support in Earth Science Education Programs: Evidence from the GLOBE Program

    Science.gov (United States)

    Penuel, B.; Korbak, C.; Shear, L.

    2003-12-01

    study, SRI researchers used the data on student data reporting activity from different partners to identify candidate sites for case studies, where we might investigate the nature of follow-up activities provided by successful partners more closely. We worked to select 2 regional partners that had evidence of high percentages of teachers trained that reported data and that also offered follow-up to teachers. Case study researchers conducted observations within 2-3 active GLOBE schools supported by each regional partner organization and interviewed teachers, principals, and partner staff. On the basis of our observation data and transcripts from interviews, we compiled profiles of schools' implementation and analyzed the core activities of each regional partner. Researchers found that keys to promoting successful implementation in one partnership were: one partnership were: close alignment with state mathematics and science initiatives; mentors that helped teachers by modeling inquiry in GLOBE and by assisting with equipment set-up and curriculum planning; and allowing room for schools to adopt diverse goals for GLOBE. In the second partnership, keys to success included a strategic approach to developing funding for the program; a focus on integration of culturally-relevant knowledge into teacher preparation; follow-up support for teachers; and use of GLOBE as an opportunity to investigate local evidence of climate change. Both partner organizations were challenged by funding limitations that prevented them from providing as much follow-up support as they believe is necessary.

  16. Exploring the relation between evidence and decision-making A political-administrative approach to health impact assessment

    International Nuclear Information System (INIS)

    Like any policy-relevant research, HIA faces the risk of not being used by decisions-makers. This article addresses the questions: 'How do policy decisions come about?' and 'How does this affect HIA?' Current literature in political-administrative sciences identifies three ways for decision-making: rational, incremental and mixed model. These models define the relationship between the policy process at stake and the HIA. In incremental or mixed model decision-making, use of HIA evidence by policy-makers is heavily dependent on their values in the context, which may result in conceptual utilization or may extend to strategic utilization. In rational decision-making, HIA provides information independent from the context, which results in instrumental utilization. HIA practitioners need to optimise utilization and produce an appropriate HIA by mapping the policy process. They can do this by asking the questions 'What? How? Who? and What context? and by maintaining continuous communication with the decision-makers. An appropriate HIA is policy-, time- and place-specific: reflecting the decision-making of the policy at stake. Furthermore, HIA concerns two policy fields with two different contexts and, in some cases, two different decision-making models. The administrative requirements for an appropriate HIA need further exploration

  17. Facilitating the implementation of evidence-based practice through contextual support and nursing leadership

    Directory of Open Access Journals (Sweden)

    Kueny A

    2015-06-01

    Full Text Available Angela Kueny,1 Leah L Shever,2 Melissa Lehan Mackin,3 Marita G Titler4 1Luther College, Decorah, IA, 2The University of Michigan Hospital and Health Center, Ann Arbor, MI, 3University of Iowa College of Nursing, Iowa City, IA, 4University of Michigan School of Nursing, Ann Arbor, MI, USA Background/purpose: Nurse managers (NMs play an important role promoting evidence-based practice (EBP on clinical units within hospitals. However, there is a dearth of research focused on NM perspectives about institutional contextual factors to support the goal of EBP on the clinical unit. The purpose of this article is to identify contextual factors described by NMs to drive change and facilitate EBP at the unit level, comparing and contrasting these perspectives across nursing units. Methods: This study employed a qualitative descriptive design using interviews with nine NMs who were participating in a large effectiveness study. To stratify the sample, NMs were selected from nursing units designated as high or low performing based on implementation of EBP interventions, scores on the Meyer and Goes research use scale, and fall rates. Descriptive content analysis was used to identify themes that reflect the complex nature of infrastructure described by NMs and contextual influences that supported or hindered their promotion of EBP on the clinical unit. Results: NMs perceived workplace culture, structure, and resources as facilitators or barriers to empowering nurses under their supervision to use EBP and drive change. A workplace culture that provides clear communication of EBP goals or regulatory changes, direct contact with CEOs, and clear expectations supported NMs in their promotion of EBP on their units. High-performing unit NMs described a structure that included nursing-specific committees, allowing nurses to drive change and EBP from within the unit. NMs from high-performing units were more likely to articulate internal resources, such as quality

  18. Brief Report: An Independent Replication and Extension of Psychometric Evidence Supporting the Theory of Mind Inventory.

    Science.gov (United States)

    Greenslade, Kathryn J; Coggins, Truman E

    2016-08-01

    This study presents an independent replication and extension of psychometric evidence supporting the Theory of Mind Inventory (ToMI). Parents of 20 children with ASD (4; 1-6; 7 years; months) and 20 with typical development (3; 1-6; 5), rated their child's theory of mind abilities in everyday situations. Other parent report and child behavioral assessments included the Social Responsiveness Scale-2, Vineland Adaptive Behavior Scales-2, Peabody Picture Vocabulary Test-4, and Clinical Evaluation of Language Fundamentals-Preschool, 2. Results revealed high internal consistency, expected developmental changes in children with typical development, expected group differences between children with and without ASD, and strong correlations with other measures of social and communication abilities. The ToMI demonstrates strong psychometrics, suggesting considerable utility in identifying theory of mind deficits in children with ASD. PMID:27106567

  19. Sodium, blood pressure, and cardiovascular disease: further evidence supporting the American Heart Association sodium reduction recommendations.

    Science.gov (United States)

    Whelton, Paul K; Appel, Lawrence J; Sacco, Ralph L; Anderson, Cheryl A M; Antman, Elliott M; Campbell, Norman; Dunbar, Sandra B; Frohlich, Edward D; Hall, John E; Jessup, Mariell; Labarthe, Darwin R; MacGregor, Graham A; Sacks, Frank M; Stamler, Jeremiah; Vafiadis, Dorothea K; Van Horn, Linda V

    2012-12-11

    Recent reports of selected observational studies and a meta-analysis have stirred controversy and have become the impetus for calls to abandon recommendations for reduced sodium intake by the US general population. A detailed review of these studies documents substantial methodological concerns that limit the usefulness of these studies in setting, much less reversing, dietary recommendations. Indeed, the evidence base supporting recommendations for reduced sodium intake in the general population remains robust and persuasive. The American Heart Association is committed to improving the health of all Americans through implementation of national goals for health promotion and disease prevention, including its recommendation to reduce dietary sodium intake to <1500 mg/d. PMID:23124030

  20. Pet ownership and cardiovascular risk reduction: supporting evidence, conflicting data and underlying mechanisms.

    Science.gov (United States)

    Arhant-Sudhir, Kanish; Arhant-Sudhir, Rish; Sudhir, Krishnankutty

    2011-11-01

    1. It is widely believed that pet ownership is beneficial to humans and that some of this benefit is through favourable effects on cardiovascular risk. In the present review, we critically examine the evidence in support of this hypothesis and present the available data with respect to major cardiovascular risk factors. 2. There is evidence that dog owners are less sedentary and have lower blood pressure, plasma cholesterol and triglycerides, attenuated responses to laboratory-induced mental stress and improved survival following myocardial infarction compared with non-pet owners. However, conflicting data exist with regard to the association between pet ownership and each of these risk factors. 3. Numerous non-cardiovascular effects of pet ownership have been reported, largely in the psychosocial domain, but the relationship is complex and can vary with demographic and social factors. 4. A unifying hypothesis is presented, linking improved mood and emotional state to decreased central and regional autonomic activity, improved endothelial function and, thus, lower blood pressure and reduced cardiac arrhythmias. 5. Overall, ownership of domestic pets, particularly dogs, is associated with positive health benefits. PMID:21824172

  1. Geophysical, archaeological and historical evidence support a solar-output model for climate change

    Science.gov (United States)

    Perry, C.A.; Hsu, K.J.

    2000-01-01

    Although the processes of climate change are not completely understood, an important causal candidate is variation in total solar output. Reported cycles in various climate-proxy data show a tendency to emulate a fundamental harmonic sequence of a basic solar-cycle length (11 years) multiplied by 2(N) (where N equals a positive or negative integer). A simple additive model for total solar-output variations was developed by superimposing a progression of fundamental harmonic cycles with slightly increasing amplitudes. The timeline of the model was calibrated to the Pleistocene/Holocene boundary at 9,000 years before present. The calibrated model was compared with geophysical, archaeological, and historical evidence of warm or cold climates during the Holocene. The evidence of periods of several centuries of cooler climates worldwide called 'little ice ages,' similar to the period anno Domini (A.D.) 1280-1860 and reoccurring approximately every 1,300 years, corresponds well with fluctuations in modeled solar output. A more detailed examination of the climate sensitive history of the last 1,000 years further supports the model. Extrapolation of the model into the future suggests a gradual cooling during the next few centuries with intermittent minor warmups and a return to near little-ice-age conditions within the next 500 years. This cool period then may be followed approximately 1,500 years from now by a return to altithermal conditions similar to the previous Holocene Maximum.

  2. Safety and quality management and administration Fiscal Year 1995 site support program plan WBS 6.7.2.6

    International Nuclear Information System (INIS)

    The mission of the Emergency, Safety, and Quality Services (ESQ) management and Program Integration is to provide leadership for the ESQ Department, coordinate business management activities of the ESQ department, and the programs it supports, as well as to plan organize, direct, and control other activities that require department-wide coordination. Primary activities include providing strategic and business planning and reporting support to ESQ management; developing and documenting ESQ management systems and procedures; coordinating ESQ's self-assessment and Award Fee self evaluation efforts; coordinating the ESQ departments's communication, total quality, cost savings, and productivity efforts; and tracking ESQ commitments and staffing data. This program element also provides program direction and performance assessment for the ESH ampersand Q division of ICF KH. The ESH ampersand Q Division educates ICF KH management and employees to protect personnel and the environment; identifies, interprets and inspects to requirements; provides administrative and field support; performs final acceptance of construction; assesses effectiveness of ICF KH programs and processes, and performs baseline ESH ampersand Q assessments

  3. NCAA Division I Student-Athlete and Athletic Administrator Perceptions of Social Support in the Athletic Department at One University in the Northwestern United States

    Science.gov (United States)

    Rothberg, Ami Lynn

    2011-01-01

    Student-athletes' and athletic administrators' perceptions of available and accessible social support in the athletic department are explored. Interviews were conducted with three athletic administrators whose job responsibilities are most focused on student-athlete welfare and 13 student-athletes from a NCAA Division I University from the Pacific…

  4. Evident?

    DEFF Research Database (Denmark)

    Plant, Peter

    2012-01-01

    Quality assurance and evidence in career guidance in Europe are often seen as self-evident approaches, but particular interests lie behind......Quality assurance and evidence in career guidance in Europe are often seen as self-evident approaches, but particular interests lie behind...

  5. Feature engineering and a proposed decision-support system for systematic reviewers of medical evidence.

    Directory of Open Access Journals (Sweden)

    Tanja Bekhuis

    Full Text Available OBJECTIVES: Evidence-based medicine depends on the timely synthesis of research findings. An important source of synthesized evidence resides in systematic reviews. However, a bottleneck in review production involves dual screening of citations with titles and abstracts to find eligible studies. For this research, we tested the effect of various kinds of textual information (features on performance of a machine learning classifier. Based on our findings, we propose an automated system to reduce screeing burden, as well as offer quality assurance. METHODS: We built a database of citations from 5 systematic reviews that varied with respect to domain, topic, and sponsor. Consensus judgments regarding eligibility were inferred from published reports. We extracted 5 feature sets from citations: alphabetic, alphanumeric(+, indexing, features mapped to concepts in systematic reviews, and topic models. To simulate a two-person team, we divided the data into random halves. We optimized the parameters of a Bayesian classifier, then trained and tested models on alternate data halves. Overall, we conducted 50 independent tests. RESULTS: All tests of summary performance (mean F3 surpassed the corresponding baseline, P<0.0001. The ranks for mean F3, precision, and classification error were statistically different across feature sets averaged over reviews; P-values for Friedman's test were .045, .002, and .002, respectively. Differences in ranks for mean recall were not statistically significant. Alphanumeric(+ features were associated with best performance; mean reduction in screening burden for this feature type ranged from 88% to 98% for the second pass through citations and from 38% to 48% overall. CONCLUSIONS: A computer-assisted, decision support system based on our methods could substantially reduce the burden of screening citations for systematic review teams and solo reviewers. Additionally, such a system could deliver quality assurance both by

  6. Further evidence supporting a role for gs signal transduction in severe malaria pathogenesis.

    Directory of Open Access Journals (Sweden)

    Sarah Auburn

    Full Text Available With the functional demonstration of a role in erythrocyte invasion by Plasmodium falciparum parasites, implications in the aetiology of common conditions that prevail in individuals of African origin, and a wealth of pharmacological knowledge, the stimulatory G protein (Gs signal transduction pathway presents an exciting target for anti-malarial drug intervention. Having previously demonstrated a role for the G-alpha-s gene, GNAS, in severe malaria disease, we sought to identify other important components of the Gs pathway. Using meta-analysis across case-control and family trio (affected child and parental controls studies of severe malaria from The Gambia and Malawi, we sought evidence of association in six Gs pathway candidate genes: adenosine receptor 2A (ADORA2A and 2B (ADORA2B, beta-adrenergic receptor kinase 1 (ADRBK1, adenylyl cyclase 9 (ADCY9, G protein beta subunit 3 (GNB3, and regulator of G protein signalling 2 (RGS2. Our study amassed a total of 2278 cases and 2364 controls. Allele-based models of association were investigated in all genes, and genotype and haplotype-based models were investigated where significant allelic associations were identified. Although no significant associations were observed in the other genes, several were identified in ADORA2A. The most significant association was observed at the rs9624472 locus, where the G allele (approximately 20% frequency appeared to confer enhanced risk to severe malaria [OR = 1.22 (1.09-1.37; P = 0.001]. Further investigation of the ADORA2A gene region is required to validate the associations identified here, and to identify and functionally characterize the responsible causal variant(s. Our results provide further evidence supporting a role of the Gs signal transduction pathway in the regulation of severe malaria, and request further exploration of this pathway in future studies.

  7. Evidence to Support the Anti-Cancer Effect of Olive Leaf Extract and Future Directions

    Science.gov (United States)

    Boss, Anna; Bishop, Karen S.; Marlow, Gareth; Barnett, Matthew P. G.; Ferguson, Lynnette R.

    2016-01-01

    The traditional Mediterranean diet (MD) is associated with long life and lower prevalence of cardiovascular disease and cancers. The main components of this diet include high intake of fruit, vegetables, red wine, extra virgin olive oil (EVOO) and fish, low intake of dairy and red meat. Olive oil has gained support as a key effector of health benefits and there is evidence that this relates to the polyphenol content. Olive leaf extract (OLE) contains a higher quantity and variety of polyphenols than those found in EVOO. There are also important structural differences between polyphenols from olive leaf and those from olive fruit that may improve the capacity of OLE to enhance health outcomes. Olive polyphenols have been claimed to play an important protective role in cancer and other inflammation-related diseases. Both inflammatory and cancer cell models have shown that olive leaf polyphenols are anti-inflammatory and protect against DNA damage initiated by free radicals. The various bioactive properties of olive leaf polyphenols are a plausible explanation for the inhibition of progression and development of cancers. The pathways and signaling cascades manipulated include the NF-κB inflammatory response and the oxidative stress response, but the effects of these bioactive components may also result from their action as a phytoestrogen. Due to the similar structure of the olive polyphenols to oestrogens, these have been hypothesized to interact with oestrogen receptors, thereby reducing the prevalence and progression of hormone related cancers. Evidence for the protective effect of olive polyphenols for cancer in humans remains anecdotal and clinical trials are required to substantiate these claims idea. This review aims to amalgamate the current literature regarding bioavailability and mechanisms involved in the potential anti-cancer action of olive leaf polyphenols. PMID:27548217

  8. Labor market effects of intrauterine exposure to nutritional deficiency: Evidence from administrative data on Muslim immigrants in Denmark.

    Science.gov (United States)

    Schultz-Nielsen, Marie Louise; Tekin, Erdal; Greve, Jane

    2016-05-01

    This paper examines whether nutritional disruptions experienced during the stage of fetal development impair an individual's labor market productivity later in life. We consider intrauterine exposure to the month of Ramadan as a natural experiment that might cause shocks to the inflow of nutrients essential for fetal development. Specifically, we use administrative data from Denmark to investigate the impact of exposure to Ramadan in utero on labor market outcomes of adult Muslim males, including employment status, annual salary, hourly wage rate, and hours of work. Our findings indicate that potential exposure to nutritional disruptions during a critical stage of fetal development is likely to have scarring effects on the fetus expressed as poor labor market outcomes later in life. Specifically, exposure to Ramadan around the 7th month of gestation results in a lower likelihood of employment and, to a lesser extent, a lower salary, and reduced labor supply. For example, the 7th month intrauterine exposure to Ramadan is associated with a 2.6 percentage points reduction in the likelihood of employment among Muslim males. We do not find an impact on the wage rate. Finally, we also document suggestive evidence that these results may partially be driven by increased disability and to a lesser extent by poor educational attainment among those who were exposed to Ramadan during this particular period in utero. PMID:26954580

  9. iRefWeb: interactive analysis of consolidated protein interaction data and their supporting evidence.

    Science.gov (United States)

    Turner, Brian; Razick, Sabry; Turinsky, Andrei L; Vlasblom, James; Crowdy, Edgard K; Cho, Emerson; Morrison, Kyle; Donaldson, Ian M; Wodak, Shoshana J

    2010-01-01

    We present iRefWeb, a web interface to protein interaction data consolidated from 10 public databases: BIND, BioGRID, CORUM, DIP, IntAct, HPRD, MINT, MPact, MPPI and OPHID. iRefWeb enables users to examine aggregated interactions for a protein of interest, and presents various statistical summaries of the data across databases, such as the number of organism-specific interactions, proteins and cited publications. Through links to source databases and supporting evidence, researchers may gauge the reliability of an interaction using simple criteria, such as the detection methods, the scale of the study (high- or low-throughput) or the number of cited publications. Furthermore, iRefWeb compares the information extracted from the same publication by different databases, and offers means to follow-up possible inconsistencies. We provide an overview of the consolidated protein-protein interaction landscape and show how it can be automatically cropped to aid the generation of meaningful organism-specific interactomes. iRefWeb can be accessed at: http://wodaklab.org/iRefWeb. Database URL: http://wodaklab.org/iRefWeb/ PMID:20940177

  10. Evidence-Based Comparison of Modularity Support Between Java and Object Teams

    CERN Document Server

    Lima, Arlindo; Monteiro, Miguel Pessoa

    2011-01-01

    Background: Aspect-oriented programming (AOP) is an emerging programming paradigm whose focus is about improving modularity, with an emphasis on the modularization of crosscutting concerns. Objective: The goal of this paper is to assess the extent to which an AOP language -ObjectTeams/Java (OT/J) -improves the modularity of a software system. This improvement has been claimed but, to the best of our knowledge, this paper is the first attempting to present quantitative evidence of it. Method: We compare functionally-equivalent implementations of the Gang-of-Four design patterns, developed in Java and OT/J, using software metrics. Results: The results of our comparison support the modularity improvement claims made in the literature. For six of the seven metrics used, the OT/J versions of the patterns obtained significantly better results. Limitations: This work uses a set of metrics originally defined for object-oriented (OO) systems. It may be the case that the metrics are biased, in that they were created in...

  11. On the observability of turbulent transport rates by Argo: supporting evidence from an inversion experiment

    Directory of Open Access Journals (Sweden)

    G. Forget

    2015-06-01

    Full Text Available Although estimation of turbulent transport parameters using inverse methods is not new, there is little evaluation of the method in the literature. Here, it is shown that extended observation of the broad scale hydrography by Argo provides a path to improved estimates of regional turbulent transport rates. Results from a 20 year ocean state estimate produced with the ECCO v4 non-linear inverse modeling framework provide supporting evidence. Turbulent transport parameter maps are estimated under the constraints of fitting the extensive collection of Argo profiles collected through 2011. The adjusted parameters dramatically reduce misfits to in situ profiles as compared with earlier ECCO solutions. They also yield a clear reduction in the model drift away from observations over multi-century long simulations, both for assimilated variables (temperature and salinity and independent variables (bio-geochemical tracers. Despite the minimal constraints imposed specifically on the estimated parameters, their geography is physically plausible and exhibits close connections with the upper ocean ocean stratification as observed by Argo. The estimated parameter adjustments furthermore have first order impacts on upper-ocean stratification and mixed layer depths over 20 years. These results identify the constraint of fitting Argo profiles as an effective observational basis for regional turbulent transport rates. Uncertainties and further improvements of the method are discussed.

  12. On the observability of turbulent transport rates by Argo: supporting evidence from an inversion experiment

    Directory of Open Access Journals (Sweden)

    G. Forget

    2015-10-01

    Full Text Available Although estimation of turbulent transport parameters using inverse methods is not new, there is little evaluation of the method in the literature. Here, it is shown that extended observation of the broad-scale hydrography by Argo provides a path to improved estimates of regional turbulent transport rates. Results from a 20-year ocean state estimate produced with the ECCO v4 (Estimating the Circulation and Climate of the Ocean, version 4 non-linear inverse modeling framework provide supporting evidence. Turbulent transport parameter maps are estimated under the constraints of fitting the extensive collection of Argo profiles collected through 2011. The adjusted parameters dramatically reduce misfits to in situ profiles as compared with earlier ECCO solutions. They also yield a clear reduction in the model drift away from observations over multi-century-long simulations, both for assimilated variables (temperature and salinity and independent variables (biogeochemical tracers. Despite the minimal constraints imposed specifically on the estimated parameters, their geography is physically plausible and exhibits close connections with the upper-ocean stratification as observed by Argo. The estimated parameter adjustments furthermore have first-order impacts on upper-ocean stratification and mixed layer depths over 20 years. These results identify the constraint of fitting Argo profiles as an effective observational basis for regional turbulent transport rate inversions. Uncertainties and further improvements of the method are discussed.

  13. Evidence-based radiology (part 1): Is there sufficient research to support the use of therapeutic injections for the spine and sacroiliac joints?

    International Nuclear Information System (INIS)

    This review article addresses the best evidence currently available for therapeutic injection therapy for conditions targeting the spine and sacroiliac joints. The article is presented by spinal region. Controversies and areas of interest for further studies are identified. There is conclusive evidence supporting the effectiveness of the caudal approach for the administration of epidural steroid injections for patients with low back pain from a variety of causes. In general, there is moderate-to-strong evidence supporting the use of transforaminal therapeutic epidural injections for lumbar nerve-root compression and facet injections for joint pain arising from these joints in the cervical, thoracic and lumbar spine, but further subgroup analysis is needed to help predict which specific patients may receive the most benefit from these procedures. No randomized controlled trials, meta-analyses or systematic reviews addressing the effectiveness of therapeutic sacroiliac joint injections have been found. For some injections, corticosteroids may not provide better outcomes compared to local anesthetic injections alone. (orig.)

  14. Evidence-based radiology (part 1): Is there sufficient research to support the use of therapeutic injections for the spine and sacroiliac joints?

    Energy Technology Data Exchange (ETDEWEB)

    Peterson, Cynthia; Hodler, Juerg [Orthopaedic University Hospital of Balgrist, Radiology, Zuerich (Switzerland)

    2010-01-15

    This review article addresses the best evidence currently available for therapeutic injection therapy for conditions targeting the spine and sacroiliac joints. The article is presented by spinal region. Controversies and areas of interest for further studies are identified. There is conclusive evidence supporting the effectiveness of the caudal approach for the administration of epidural steroid injections for patients with low back pain from a variety of causes. In general, there is moderate-to-strong evidence supporting the use of transforaminal therapeutic epidural injections for lumbar nerve-root compression and facet injections for joint pain arising from these joints in the cervical, thoracic and lumbar spine, but further subgroup analysis is needed to help predict which specific patients may receive the most benefit from these procedures. No randomized controlled trials, meta-analyses or systematic reviews addressing the effectiveness of therapeutic sacroiliac joint injections have been found. For some injections, corticosteroids may not provide better outcomes compared to local anesthetic injections alone. (orig.)

  15. Managing symptoms during cancer treatments: evaluating the implementation of evidence-informed remote support protocols

    Directory of Open Access Journals (Sweden)

    Stacey Dawn

    2012-11-01

    Full Text Available Abstract Background Management of cancer treatment-related symptoms is an important safety issue given that symptoms can become life-threatening and often occur when patients are at home. With funding from the Canadian Partnership Against Cancer, a pan-Canadian steering committee was established with representation from eight provinces to develop symptom protocols using a rigorous methodology (CAN-IMPLEMENT©. Each protocol is based on a systematic review of the literature to identify relevant clinical practice guidelines. Protocols were validated by cancer nurses from across Canada. The aim of this study is to build an effective and sustainable approach for implementing evidence-informed protocols for nurses to use when providing remote symptom assessment, triage, and guidance in self-management for patients experiencing symptoms while undergoing cancer treatments. Methods A prospective mixed-methods study design will be used. Guided by the Knowledge to Action Framework, the study will involve (a establishing an advisory knowledge user team in each of three targeted settings; (b assessing factors influencing nurses’ use of protocols using interviews/focus groups and a standardized survey instrument; (c adapting protocols for local use, ensuring fidelity of the content; (d selecting intervention strategies to overcome known barriers and implementing the protocols; (e conducting think-aloud usability testing; (f evaluating protocol use and outcomes by conducting an audit of 100 randomly selected charts at each of the three settings; and (g assessing satisfaction with remote support using symptom protocols and change in nurses’ barriers to use using survey instruments. The primary outcome is sustained use of the protocols, defined as use in 75% of the calls. Descriptive analysis will be conducted for the barriers, use of protocols, and chart audit outcomes. Content analysis will be conducted on interviews/focus groups and usability testing

  16. The past, present, and future of National Aeronautics and Space Administration spaceflight diet in support of microgravity rodent experiments.

    Science.gov (United States)

    Sun, Gwo-Shing; Tou, Janet C; Yu, Diane; Girten, Beverly E; Cohen, Jacob

    2014-02-01

    Rodents have been the most frequently flown animal model used to study physiological responses to the space environment. In support of future of space exploration, the National Aeronautics and Space Administration (NASA) envisions an animal research program focused on rodents. Therefore, the development of a rodent diet that is suitable for the spaceflight environment including long duration spaceflight is a high priority. Recognizing the importance of nutrition in affecting spaceflight physiological responses and ensuring reliable biomedical and biological science return, NASA developed the nutrient-upgraded rodent food bar (NuRFB) as a standard diet for rodent spaceflight. Depending on future animal habitat hardware and planned spaceflight experiments, modification of the NuRFB or development of a new diet formulation may be needed, particularly for long term spaceflights. Research in this area consists primarily of internal technical reports that are not readily accessible. Therefore, the aims of this contribution are to provide a brief history of the development of rodent spaceflight diets, to review the present diet used in rodent spaceflight studies, and to discuss some of the challenges and potential solutions for diets to be used in future long-term rodent spaceflight studies. PMID:24012282

  17. Support for Crater Count Chronometry and Evidence for Obliquity-driven Ice Deposition on Mars

    Science.gov (United States)

    Hartmann, William K.

    2007-10-01

    In December 2006, Malin et al. (Science) reported discovery of small Martian craters forming on Mars in the last 7 years. Diameters are 10 to 20 m for best detections. The formation rate for these craters is within a factor 2-3 of the rates I've used in the isochron system I developed at PSI (2005 Icarus) - which is within the uncertainty limits of factor 2-4 that I have quoted for the system. This supports the conclusion that order-of-magnitude ages can be measured for young, kilometer-scale Martian landforms, by counting small craters. If Malin et al. are right, the method can be refined to considerable precision in the future, by better measurement of small crater production rates. I have applied this dating system to tongue-shaped flows and debris aprons east of Hellas. These apparently involve flow of ice or ice/soil mixtures (Costard et al. 2002 Science). Surface features at lateral topographic scales of 10-20m and 3-6m depth consistently give ages of a few My to a few 10s My on the flow units, and older ages outside the flow units. This is true whether Hartmann, Malin, or Neukum cratering data are used. These ages are just in the range of the last few cycles of high obliquity (Laskar et al. 2002 Nature). Strikingly, the ice features are exactly in one of the two moderate-latitude regions with unusually high ice deposition at high obliquity, according to global climate models by Forget (2007 LPSC, private communication). I conclude that crater count chronometry is viable and we have evidence of localized high rates of ice deposition, and possible water release, on mid-latitude Mars within the last few tens of My.

  18. New sedimentological evidence supporting a catastrophic meltwater discharge event along the Beaufort margin, Arctic Ocean

    Science.gov (United States)

    Klotsko, S.; Driscoll, N. W.; Keigwin, L. D.; Mendenhall, B.

    2015-12-01

    In 2013, a cruise on the USCGC Healy mapped the Beaufort margin from Barrow, AK into the Amundsen Gulf using a towed CHIRP subbottom profiler and a hull-mounted Knudsen CHIRP subbottom profiler to study the deglaciation of the margin. Sediment cores were also acquired. New grain size analyses for three sediment cores will be presented. These records help constrain the flooding events captured in the existing grain size data from JPC 15, just east of the Mackenzie trough. This core shows evidence of multiple ice rafted debris events that were likely sourced from the retreat of the Amundsen ice stream. These layers have peaks in grain size around ~20 microns compared to the ~5 micron average for the rest of the core. The grain size peaks correlate to the high amplitude reflectors observed in the seismic CHIRP data. Similar reflectors are observed in the seismic data from two of the new core locations, one in the Mackenzie trough and one east of the trough. The seismic data from these stations also record a thick sediment package that is ~7 meters thick at its depocenter. This layer is interpreted to record a massive meltwater discharge event that entered the Arctic via the Mackenzie River. Oxygen isotope data from JPC 15 support an event at this location based on the covarying benthic and planktonic records. In our conceptual model, the pulses of freshwater from the Amundsen Gulf likely freshened the margin sufficiently that the major discharge event was then able to push the system over the edge. This catastrophic glacial lake draining out the Mackenzie River into the Beaufort Sea and export out of the Arctic into the North Atlantic caused diminished meridional overturning circulation - slowing of the conveyor belt thermohaline circulation - which, in turn, potentially caused the Younger Dryas cold period.

  19. Coherence of evidence from systematic reviews as a basis for evidence strength - a case study in support of an epistemological proposition

    Directory of Open Access Journals (Sweden)

    Mickenautsch Steffen

    2012-01-01

    Full Text Available Abstract Background This article aims to offer, on the basis of Coherence theory, the epistemological proposition that mutually supportive evidence from multiple systematic reviews may successfully refute radical, philosophical scepticism. Methods A case study including seven systematic reviews is presented with the objective of refuting radical philosophical scepticism towards the belief that glass-ionomer cements (GIC are beneficial in tooth caries therapy. The case study illustrates how principles of logical and empirical coherence may be applied as evidence in support of specific beliefs in healthcare. Results The results show that radical scepticism may epistemologically be refuted on the basis of logical and empirical coherence. For success, several systematic reviews covering interconnected beliefs are needed. In praxis, these systematic reviews would also need to be of high quality and its conclusions based on reviewed high quality trials. Conclusions A refutation of radical philosophical scepticism to clinical evidence may be achieved, if and only if such evidence is based on the logical and empirical coherence of multiple systematic review results. Practical application also requires focus on the quality of the systematic reviews and reviewed trials.

  20. 论行政诉讼案卷外证据之范围%On the Scope of the Evidence Outside Files in Administrative Litigation

    Institute of Scientific and Technical Information of China (English)

    常晓云

    2012-01-01

    The evidences outside administrative files exclusion principle is the specific rule of evidence in administrative litigation,which contains two aspects:the scope and the legal effect of the evidences outside files.The evidences outside files should be excluded because of the closed characteristics of the administrative file and the judicial review of the nature of administrative litigation.The principle shall be studied based on the analysis of the law,by discussing the range of the evidences outside files,clearing its legal effect and making recommendations on administrative judicial practice and legislation perfection.%案卷外证据排除规则乃行政诉讼特有之证据规则,其包含两方面的内涵:案卷外证据之范围与案卷外证据之法律效果。基于行政案卷封闭性之特点,以及行政诉讼司法复审之特性,行政诉讼案卷外证据应予排除。对案卷外证据排除规则的研究应以分析我国的法律规定为基础,探讨案卷外证据之应有范围,明确各项案卷外证据的法律效果,并对行政审判实践与相关立法的完善提出建议。

  1. Dronedarone: evidence supporting its therapeutic use in the treatment of atrial fibrillation

    OpenAIRE

    Sullivan, Renee M; Brian Olshansky

    2010-01-01

    Renee M Sullivan, Brian OlshanskyDivision of Cardiovascular Medicine, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USAIntroduction: Dronedarone, a benzofuran derivative with a structure similar to amiodarone, has been developed as a potential therapy for patients with atrial fibrillation.Aim: To review the published evidence regarding the efficacy and safety of dronedarone use in patients with atrial fibrillation.Evidence review: Available evidence suggests that dronedarone 400 ...

  2. Effects of School-Wide Positive Behavioral Interventions and Supports on Internalizing Problems: Current Evidence and Future Directions

    Science.gov (United States)

    McIntosh, Kent; Ty, Sophie V.; Miller, Lynn D.

    2014-01-01

    School-Wide Positive Behavioral Interventions and Supports (SWPBIS) has a large evidence base for preventing and addressing externalizing problem behavior, but there is little research examining its effects on internalizing problems, such as anxiety and depression. Given the prevalence of internalizing problems in today's children and youth,…

  3. The Relationship Between College Zoology Students' Religious Beliefs and Their Ability to Objectively View the Scientific Evidence Supporting Evolutionary Theory.

    Science.gov (United States)

    Sinclair, Anne; Baldwin, Beatrice

    An anonymous 12-item, multiple-choice questionnaire was administered to 218 southern college, introductory zoology students prior to and following a study of evolutionary theory to assess their understanding and acceptance of the credibility of the evidence supporting the theory. Key topics addressed were the history of evolutionary thought, basic…

  4. Supporting the use of research evidence in the Americas through an online "one-stop shop": the EVIPNet VHL.

    Science.gov (United States)

    Moat, K A; Lavis, J N

    2014-12-01

    Since the release of the 'World Report on Knowledge for Better Health' in 2004, a transformation has occurred in the field of health policy and systems research that has brought with it an increased emphasis on supporting the use of research evidence in the policy process. There has been an identified need for comprehensive online "one-stop shops" that facilitate the timely retrieval of research evidence in the policy process. This report highlights the EVIPNet VHL, a recently established project that was developed to meet the need for online repositories of relevant evidence to support knowledge translation efforts in the Americas, which can help contribute to strengthening health systems in the region. PMID:26247998

  5. From Evidence to Decision Support in Cancer Screening; Application of Miscan Models

    NARCIS (Netherlands)

    R. Boer (Rob)

    2000-01-01

    textabstractMaking decisions to introduce or change cancer screening that are based on observed evidence is not straight forward. Even if there is evidence available from randomised controlled trials that clearly proves a reduction in mortality from the cancer in question, there are still several is

  6. Analysis of the National Modernizers Network for the Support of the Public Administration Reform Process from Romania

    Directory of Open Access Journals (Sweden)

    Alina PROFIROIU

    2010-10-01

    Full Text Available The reform process of the state and implicitly of the public administration was a priority for the past governments of Romania. During 2004- 2009, within the reform process, the main actors involved in the coordination, implementation and monitoring of reform measures were: the Prime Minister, the Superior Council for Public Administration Reform, Public Policy Coordination and Structural Adjustment, the Ministry of Public Finance, the General Secretariat of Government, Ministry of Administration and Interior (renamed for a short time Ministry of Interior and Administrative Reform, the Central Unit for Public Administration Reform, National Institute of Administration, the National Agency of Civil Servants, and the National Modernizers Network. For evaluation of aspects related to the reform process it was designed a selective research within the members of the National Modernizers Network, for assessing their perception of the public administration reform undertaken by the institutions presented above. Evaluating their opinion can be an important point in the revitalization of the area of the administration reform process. Also, the research conducted aimed at assessing the degree of modernizers’ involvement in activities related to important aspects of the reform process: strategic planning, formulating and evaluating public policies, financial management, human resources management, decentralization, introduction of new information and communication technologies and administrative simplification.

  7. How Administrators Can Help Novice Special Education Teachers Thrive: Induction Practices That Make a Difference. Induction Insights. Supporting Special Education Teachers-Administrators [AII-11

    Science.gov (United States)

    National Center to Inform Policy and Practice in Special Education Professional Development, 2010

    2010-01-01

    Increasingly, principals play an important role in new special education teacher induction. Although novice special education teachers benefit from the same types of support and induction that their general education colleagues receive, certain aspects of their experience require additional attention. This Brief summarizes what principals can…

  8. Marriage Squeeze and Intergenerational Support in Contemporary Rural China: Evidence from X County of Anhui Province.

    Science.gov (United States)

    Jin, Xiaoyi; Guo, Qiuju; Feldman, Marcus W

    2015-01-01

    With China's gender imbalance and increasingly severe male marriage squeeze, patterns of intergenerational support in rural areas are likely to undergo significant change. Using data from a survey of four towns from X county in Anhui province carried out in 2008, this article analyzes the effects of sons' marital status on intergenerational support. Random-effect regression analysis shows that son's marital status has strong effects on financial support to and coresidence with parents. Compared with married sons, older unmarried sons (so-called forced bachelors) tend to provide less financial support to their parents and are more likely to live with their parents. Parents' support of sons, as well as the parents' own needs and sons' capabilities all affect the support provided by sons. These results show that both theories of exchange and altruism are simultaneously relevant in the context of the marriage squeeze of contemporary rural China. PMID:26243325

  9. Ocean Acidification and the End-Permian Mass Extinction: To What Extent does Evidence Support Hypothesis?

    OpenAIRE

    Marie-Béatrice Forel; Pierre-Yves Collin; Yue Li; Stephen Kershaw; Sylvie Crasquin

    2012-01-01

    Ocean acidification in modern oceans is linked to rapid increase in atmospheric CO2, raising concern about marine diversity, food security and ecosystem services. Proxy evidence for acidification during past crises may help predict future change, but three issues limit confidence of comparisons between modern and ancient ocean acidification, illustrated from the end-Permian extinction, 252 million years ago: (1) problems with evidence for ocean acidification preserved in sedimentary rocks, wh...

  10. Career Pathing among General Administrative and Support Services Employees Based on Holland?s Typology of Personality Theory and Personal Style Inventory

    Science.gov (United States)

    Mendoza, Catalino N.

    2009-01-01

    The study is about the prevailing differences, commonalities and significant contributions of the career pathing among the general administrative and support services employees based on Holland's Typology of Personality Theory and Personal Style Inventory of selected higher educational institutions in Metro Manila.

  11. A framework for production of systematic review based briefings to support evidence-informed decision-making

    Directory of Open Access Journals (Sweden)

    Chambers Duncan

    2012-07-01

    Full Text Available Abstract Background We have developed a framework for translating existing sources of synthesized and quality-assessed evidence, primarily systematic reviews, into actionable messages in the form of short accessible briefings. The service aims to address real-life problems in response to requests from decision-makers. Development of the framework was based on a scoping review of existing resources and our initial experience with two briefing topics, including models of service provision for young people with eating disorders. We also drew on previous experience in dissemination research and practice. Where appropriate, we made use of the SUPporting POlicy relevant Reviews and Trials (SUPPORT tools for evidence-informed policymaking. Findings To produce a product that it is fit for this purpose it has been necessary to go beyond a traditional summary of the available evidence relating to effectiveness. Briefings have, therefore, included consideration of cost effectiveness, local applicability, implications relating to local service delivery, budgets, implementation and equity. Our first evidence briefings produced under this framework cover diagnostic endoscopy by specialist nurses and integrated care pathways in mental healthcare settings. Conclusions The framework will enable researchers to present and contextualize evidence from systematic reviews and other sources of synthesized and quality-assessed evidence. The approach is designed to address the wide range of questions of interest to decision-makers, especially those commissioning services or managing service delivery and organization in primary or secondary care. Evaluation of the use and usefulness of the evidence briefings we produce is an integral part of the framework and will help to fill a gap in the literature.

  12. Episodic Representations Support Early Semantic Learning: Evidence from Midazolam Induced Amnesia

    Science.gov (United States)

    Merritt, Paul; Hirshman, Elliot; Zamani, Shane; Hsu, John; Berrigan, Michael

    2006-01-01

    Current controversy exists regarding the role of episodic representations in the formation of long-term semantic memories. Using the drug "midazolam" to induce temporary amnesia we tested participants' memories for newly learned facts in a semantic cue condition or an episodic and semantic cue condition. Following midazolam administration, memory…

  13. Parental Maltreatment, Bullying, and Adolescent Depression: Evidence for the Mediating Role of Perceived Social Support

    Science.gov (United States)

    Seeds, Pamela M.; Harkness, Kate L.; Quilty, Lena C.

    2010-01-01

    The support deterioration model of depression states that stress deteriorates the perceived availability and/or effectiveness of social support, which then leads to depression. The present study examined this model in adolescent depression following parent-perpetrated maltreatment and peer-perpetrated bullying, as assessed by a rigorous contextual…

  14. Gender, social support, and well-being: Evidence from a Greek community sample

    Directory of Open Access Journals (Sweden)

    Konstantinos Kafetsios

    2007-12-01

    Full Text Available The importance of social support for psychological well-being has been aptly highlighted in epidemiological and psychological research. However, it is not clear from the existing research whether gender differences in structural (relationship status, network size, frequency of interactions with friends and functional (support satisfaction aspects of social support exist and -if they do- to what extent they affect males’ and females’ well-being. Hierarchical regression analyses of crossectional data from a Greek community sample showed that support satisfaction was an important predictor of well-being outcomes in males whereas several structural indicators were predictors of different well-being outcomes in females. Females’ anxiety, perceived stress, and loneliness were adversely affected by frequency of interaction with acquaintances. The results are discussed with regard to gender-role differences that may be underlying the social support effects on well-being, as well as related cultural values.

  15. Analysis of the National Modernizers Network for the Support of the Public Administration Reform Process from Romania

    OpenAIRE

    Alina PROFIROIU; Andrei, Tudorel; Marian NICA; Elena Daniela ŞTEFĂNESCU

    2010-01-01

    The reform process of the state and implicitly of the public administration was a priority for the past governments of Romania. During 2004- 2009, within the reform process, the main actors involved in the coordination, implementation and monitoring of reform measures were: the Prime Minister, the Superior Council for Public Administration Reform, Public Policy Coordination and Structural Adjustment, the Ministry of Public Finance, the General Secretariat of Government, Ministry of Administra...

  16. Does evidence support physiotherapy management of adult female chronic pelvic pain? A systematic review

    DEFF Research Database (Denmark)

    Loving, Sys; Nordling, Jørgen; Jaszczak, Poul; Thomsen, Thordis

    2012-01-01

    . Trial inclusion, data extraction according to predefined criteria and risk of bias assessment were performed by two independent authors. Methodological quality of the included clinical intervention studies was assessed using The Cochrane Collaboration's tool for assessing risk of bias. Review Manager...... dysfunction is frequently cited as a possible aetiology. Physiotherapy is therefore recommended as one treatment modality. The aim of this systematic review was to source and critically evaluate the evidence for an effect of physiotherapy on pain, physical activity and quality of life in the treatment of...... reviews should be interpreted with caution due to the lack of a sufficient evidence base. Only small and largely non-randomised studies have been undertaken of physiotherapeutic interventions and this greatly limits the available evidence on which to base clinical practice. High quality randomised...

  17. Danish evidence-based clinical guideline for use of nutritional support in pulmonary rehabilitation of undernourished patients with stable COPD

    DEFF Research Database (Denmark)

    Beck, Anne Marie; Iepsen, Ulrik Winning; Topperup, Randi;

    2015-01-01

    Background and aims Disease-related under-nutrition is a common problem in individuals with COPD. The rationale for nutritional support in pulmonary rehabilitation therefore seems obvious. However there is limited evidence regarding the patient-relevant outcomes i.e. activities of daily living (ADL...... possible, or meta-analyses from existing guidelines or systematic reviews were adapted. The results were used for labeling and wording of the recommendations. Results Data from 12 randomized controlled trials were included in a systematic review, which formed the basis for our recommendations as no new...... primary studies had been published. There were evidence of moderate quality that nutritional support for undernourished patients with COPD lead to a weight gain of 1.7 kg (95% confidence interval: 1.3 to 2.2 kg), but the effect was quantified as a mean change from baseline, which is less reliable. There...

  18. SAT administrator

    International Nuclear Information System (INIS)

    SAT Administrator is the Information System for Nuclear Power Plant Personnel Training Program Design. It supports the design of training programs in the following phases: job analysis; task analysis; competency analysis; task competency association; definition of learning objectives to competencies; training program design; definition of test items. The general structure of the database and management software supports application of the SAT Administrator in any nuclear power installation

  19. Executive summary: evaluation of the evidence to support practice guidelines for nutritional care of preterm infants-the Pre-B Project.

    Science.gov (United States)

    Raiten, Daniel J; Steiber, Alison L; Hand, Rosa K

    2016-02-01

    Preterm birth (infants born at United States and globally. No universally accepted practice guidelines exist for the nutritional care of preterm infants. To address the current state of knowledge and to support systematic reviews that will be used to develop evidence-informed guidance, a consortium consisting of the American Academy of Pediatrics, the ASN, the American Society for Parenteral and Enteral Nutrition, the Academy of Nutrition and Dietetics, the Food and Drug Administration, the CDC, the USDA/Agricultural Research Service (USDA/ARS), and the Eunice Kennedy Shriver National Institute of Child Health and Human Development/NIH initiated the Pre-B Project. The project included the constitution of 4 thematic working groups charged with the following tasks: 1) develop a series of topics/questions for which there is sufficient evidence to support a systematic review process to be conducted by the Academy of Nutrition and Dietetics' Evidence Analysis Library (EAL), leading to the development of new guidelines for nutritional care of preterm infants, and 2) develop a targeted research agenda to address priority gaps in our understanding of the role of nutrition in the health and development of preterm/neonatal intensive care unit infants. This review consists of a project overview including a summary of a workshop hosted by the USDA/ARS Children's Nutrition Research Center and summary reports of the 4 working groups established to address the following themes: 1) nutrient specifications, 2) clinical/practical issues in enteral feeding, 3) gastrointestinal and surgical issues, and 4) current standards for assessing infant feeding outcomes. These reports will serve as the basis for the ultimate guideline development process to be conducted by the Academy of Nutrition and Dietetics' EAL. PMID:26791179

  20. Review and comparison of clinical evidence submitted to support European Medicines Agency market authorization of orphan-designated oncological treatments

    OpenAIRE

    Winstone, Julie; Chadda, Shkun; Ralston, Stephen; Sajosi, Peter

    2015-01-01

    Background Clinical trials for treatments indicated for orphan diseases may be limited due to the low prevalence of such diseases; this can result in implications for both regulatory and health economic perspectives. This study assessed the pivotal clinical evidence packages submitted to support applications for European Medicines Agency (EMA) marketing authorizations for treatments for orphan conditions, in relation to the size of the eligible patient population. Methods Approved treatments ...

  1. Randomised controlled trial of clinical decision support tools to improve learning of evidence based medicine in medical students

    OpenAIRE

    Leung, Gabriel M; Johnston, Janice M; Tin, Keith Y K; Wong, Irene O. L.; Ho, Lai-Ming; Lam, Wendy W.T.; Lam, Tai-hing

    2003-01-01

    Objective: To assess the educational effectiveness on learning evidence based medicine of a handheld computer clinical decision support tool compared with a pocket card containing guidelines and a control. Design: Randomised controlled trial. Setting University of Hong Kong, 2001. Participants: 169 fourth year medical students. Main outcome measures: Factor and individual item scores from a validated questionnaire on five key self reported measures: personal application and current use of evi...

  2. Does Government Support for Private Innovation Matter? Firm-Level Evidence from Turkey and Poland

    OpenAIRE

    Grabowski, Wojciech; Pamukcu, Teoman; Szczygielski, Krzysztof; Tandogan, Sinan

    2013-01-01

    The aim of the project is to analyze government support for innovation in a comparative perspective by first examining the main existing instruments of financial support for innovation in Turkey and Poland, and secondly to assess their effectiveness by applying recent econometric techniques to firm-level data for both countries obtained from the Community Innovation Survey (CIS). Comparing Turkey to Poland is both meaningful and promising from a policy-analysis point of view. Both countries a...

  3. Waterpipe tobacco smoking: what is the evidence that it supports nicotine/tobacco dependence?

    OpenAIRE

    Aboaziza, Eiman; Eissenberg, Thomas

    2014-01-01

    Objective Waterpipe tobacco smoking (WTS) involves passing tobacco smoke through water prior to inhalation, and has spread worldwide. This spread becomes a public health concern if it is associated with tobacco-caused disease and if WTS supports tobacco/nicotine dependence. A growing literature demonstrates that WTS is associated with disability, disease and death. This narrative review examines if WTS supports nicotine/tobacco dependence, and is intended to help guide tobacco control efforts...

  4. Molecular archeological evidence in support of the repeated loss of a papillomavirus gene

    Science.gov (United States)

    Van Doorslaer, Koenraad; McBride, Alison A.

    2016-01-01

    It is becoming clear that, in addition to gene gain, the loss of genes may be an important evolutionary mechanism for many organisms. However, gene loss is often associated with an increased mutation rate, thus quickly erasing evidence from the genome. The analysis of evolutionarily related sequences can provide empirical evidence for gene loss events. This paper analyzes the sequences of over 300 genetically distinct papillomaviruses and provides evidence for a role of gene loss during the evolution of certain papillomavirus genomes. Phylogenetic analysis suggests that the viral E6 gene was lost at least twice. Despite belonging to distant papillomaviral genera, these viruses lacking a canonical E6 protein may potentially encode a highly hydrophobic protein from an overlapping open reading frame, which we designate E10. Evolutionary pressure working on this alternative frame, may explain why, despite having lost the E6 open reading frame between 20 and 60 million years ago, evidence of an E6-like protein is conserved. PMID:27604338

  5. Social Stories[TM]: Does the Research Evidence Support the Popularity?

    Science.gov (United States)

    Styles, Adam

    2011-01-01

    The use of Social Stories[TM] appears to be popular among educational psychologists (EPs) and other children's services professionals as an intervention for enhancing the social functioning of children with Autism Spectrum Disorders (ASDs). This article explores and evaluates the research evidence upon which this apparent popularity is based.…

  6. Current Evidence Supporting the Link Between Dietary Fatty Acids and Cardiovascular Disease.

    Science.gov (United States)

    Hammad, Shatha; Pu, Shuaihua; Jones, Peter J

    2016-05-01

    Lack of consensus exists pertaining to the scientific evidence regarding effects of various dietary fatty acids on cardiovascular disease (CVD) risk. The objective of this article is to review current evidence concerning cardiovascular health effects of the main dietary fatty acid types; namely, trans (TFA), saturated (SFA), polyunsaturated (PUFA; n-3 PUFA and n-6 PUFA), and monounsaturated fatty acids (MUFA). Accumulating evidence shows negative health impacts of TFA and SFA; both may increase CVD risk. Policies have been proposed to reduce TFA and SFA consumption to less than 1 and 7 % of energy intake, respectively. Cardiovascular health might be promoted by replacing SFA and TFA with n-6 PUFA, n-3 PUFA, or MUFA; however, the optimal amount of PUFA or MUFA that can be used to replace SFA and TFA has not been defined yet. Evidence suggests of the potential importance of restricting n-6 PUFA up to 10 % of energy and obtaining an n-6/n-3 ratio as close as possible to unity, along with a particular emphasis on consuming adequate amounts of essential fatty acids. The latest evidence shows cardioprotective effects of MUFA-rich diets, especially when MUFA are supplemented with essential fatty acids; namely, docosahexaenoic acid. MUFA has been newly suggested to be involved in regulating fat oxidation, energy metabolism, appetite sensations, weight maintenance, and cholesterol metabolism. These favorable effects might implicate MUFA as the preferable choice to substitute for other fatty acids, especially given the declaration of its safety for up to 20 % of total energy. PMID:26719191

  7. Administrative Data Repository (ADR)

    Data.gov (United States)

    Department of Veterans Affairs — The Administrative Data Repository (ADR) was established to provide support for the administrative data elements relative to multiple categories of a person entity...

  8. A BAYESIAN ABDUCTION MODEL FOR EXTRACTING THE MOST PROBABLE EVIDENCE TO SUPPORT SENSEMAKING

    Directory of Open Access Journals (Sweden)

    Paul Munya

    2015-01-01

    Full Text Available In this paper, we discuss the development of a Bayesian Abduction Model of Sensemaking Support (BAMSS as a tool for information fusion to support prospective sensemaking. Currently, BAMSS can identify the Most Probable Explanation from a Bayesian Belief Network (BBN and extract the prevalent conditional probability values to help the sensemaking analysts to understand the cause-effect of the adversary information. Actual vignettes from databases of modern insurgencies and asymmetry warfare are used to validate the performance of BAMSS. BAMSS computes the posterior probability of the network edges and performs information fusion using a clustering algorithm. In the model, the friendly force commander uses the adversary information to prospectively make sense of the enemy’s intent. Sensitivity analyses were used to confirm the robustness of BAMSS in generating the Most Probable Explanations from a BBN through abductive inference. The simulation results demonstrate the utility of BAMSS as a computational tool to support sense making.

  9. Fostering integrity in postgraduate research: an evidence-based policy and support framework.

    Science.gov (United States)

    Mahmud, Saadia; Bretag, Tracey

    2014-01-01

    Postgraduate research students have a unique position in the debate on integrity in research as students and novice researchers. To assess how far policies for integrity in postgraduate research meet the needs of students as "research trainees," we reviewed online policies for integrity in postgraduate research at nine particular Australian universities against the Australian Code for Responsible Conduct of Research (the Code) and the five core elements of exemplary academic integrity policy identified by Bretag et al. (2011 ), i.e., access, approach, responsibility, detail, and support. We found inconsistency with the Code in the definition of research misconduct and a lack of adequate detail and support. Based on our analysis, previous research, and the literature, we propose a framework for policy and support for postgraduate research that encompasses a consistent and educative approach to integrity maintained across the university at all levels of scholarship and for all stakeholders. PMID:24228976

  10. Y-chromosome evidence supports asymmetric dog introgression into eastern coyotes

    OpenAIRE

    Wheeldon, Tyler J; Rutledge, Linda Y; Patterson, Brent R; White, Bradley N; Wilson, Paul J.

    2013-01-01

    Hybridization has played an important role in the evolutionary history of Canis species in eastern North America. Genetic evidence of coyote–dog hybridization based on mitochondrial DNA (mtDNA) is lacking compared to that based on autosomal markers. This discordance suggests dog introgression into coyotes has potentially been male biased, but this hypothesis has not been formally tested. Therefore, we investigated biparentally, maternally, and paternally inherited genetic markers in a sample ...

  11. Body of evidence supporting the clinical use of 3-D Multisegment Foot Models: a systematic review

    OpenAIRE

    Deschamps, Kevin; Staes, Filip; Roosen, Philip; Nobels, Frank; Desloovere, Kaat; Bruyninckx, Herman; Matricali, Giovanni

    2011-01-01

    Background: A critical component in the characterization of foot mechanics during clinical gait analysis is the quantitative measurement of foot kinematics. Currently, the use of 3-D multisegment foot models (3DMFMs) is popular in gait laboratories as it would seem to be an adequate tool for the in vivo analysis of dynamic foot kinematics. This systematic review identifies and evaluates current evidence for the use of 3DMFMs in clinical gait analysis. Methods: A targeted search strategy tr...

  12. Plantar fasciitis – to jab or to support? A systematic review of the current best evidence

    Directory of Open Access Journals (Sweden)

    Uden H

    2011-05-01

    Full Text Available Hayley Uden1, Eva Boesch1, Saravana Kumar1,21Division of Health Sciences, 2International Centre for Allied Health Evidence, University of South Australia, North Terrace, Adelaide, South Australia, AustraliaBackground: Plantar fasciitis is a common condition routinely managed by podiatrists in the community and is widely treated conservatively. Two commonly used treatments for plantar fasciitis are customized functional foot orthoses and corticosteroid injections. While common to clinical practice, the evidence base underpinning these treatment strategies is unknown. Therefore, the aim of this systematic review was to assess the effectiveness and safety of customized functional foot orthoses and corticosteroid injections in the treatment of plantar fasciitis.Methods: A systematic literature search was conducted. Experimental studies, in English, from 1998 to 2010 were accepted for inclusion in this review. The PEDro quality assessment tool and the National Health and Medical Research Council's hierarchy of evidence were used to assess the quality of the included studies.Results: Six randomized controlled trials which met the selection criteria were included in this review. Four reported on customized functional foot orthoses and 2 on corticosteroid injections. Current best available evidence highlights that both customized functional foot orthoses and corticosteroid injections can lead to a decrease in pain associated with plantar fasciitis. Additionally, customized functional foot orthoses may also provide an additional benefit in terms of increased functional ability in patients with plantar fasciitis. Corticosteroid injections may have side effects, especially pain (from the injection.Conclusion: Both customized functional foot orthoses and corticosteroid injections can lead to reduction in pain associated with plantar fasciitis. While customized functional foot orthoses may increase the functional outcomes in patients with plantar fasciitis

  13. Piece Rates and Workplace Injury: Does Survey Evidence Support Adam Smith?

    OpenAIRE

    K A Bender; Green, C.; J S Heywood

    2010-01-01

    While piece rates are routinely associated with greater productivity and higher wages, they may also generate unanticipated effects. This paper uses cross-country European data to provide among the first broad survey evidence of a strong link between piece rates and workplace injury. Despite unusually good controls for workplace hazards, job characteristics and worker effort, workers on piece rates suffer a large 5 percentage point greater likelihood of injury. As injury rates are typically n...

  14. The Role of Glucose on Executive Control Vigor: Evidence inSupport of Comparative Research

    OpenAIRE

    Miller, Holly C.

    2012-01-01

    The central executive is theorized to be an overarching cognitive system responsible for coordinatingprocesses that enable self-control (i.e., inhibiting habitual responses), persistence at mental andphysical tasks, emotional regulation and working memory (Gailliot, 2008; Miller & Cohen, 2001).There is evidence that the executive system relies on glucose as its energy resource (Gailliot et al.,2007) and that when humans invoke the central executive they expend large quantities of glucose.When...

  15. Do knowledge infrastructure facilities support Evidence-Based Practice in occupational health? An exploratory study across countries among occupational physicians enrolled on Evidence-Based Medicine courses

    Directory of Open Access Journals (Sweden)

    van Dijk Frank JH

    2009-01-01

    Full Text Available Abstract Background Evidence-Based Medicine (EBM is an important method used by occupational physicians (OPs to deliver high quality health care. The presence and quality of a knowledge infrastructure is thought to influence the practice of EBM in occupational health care. This study explores the facilities in the knowledge infrastructure being used by OPs in different countries, and their perceived importance for EBM practice. Methods Thirty-six OPs from ten countries, planning to attend an EBM course and to a large extent recruited via the European Association of Schools of Occupational Medicine (EASOM, participated in a cross-sectional study. Results Research and development institutes, and knowledge products and tools are used by respectively more than 72% and more than 80% of the OPs and they are rated as being important for EBM practice (more than 65 points (range 0–100. Conventional knowledge access facilities, like traditional libraries, are used often (69% but are rated as less important (46.8 points (range 0–100 compared to the use of more novel facilities, like question-and-answer facilities (25% that are rated as more important (48.9 points (range 0–100. To solve cases, OPs mostly use non evidence-based sources. However, they regard the evidence-based sources that are not often used, e.g. the Cochrane library, as important enablers for practising EBM. The main barriers are lack of time, payment for full-text articles, language barrier (most texts are in English, and lack of skills and support. Conclusion This first exploratory study shows that OPs use many knowledge infrastructure facilities and rate them as being important for their EBM practice. However, they are not used to use evidence-based sources in their practice and face many barriers that are comparable to the barriers physicians face in primary health care.

  16. Effects of Work Environment on Transfer of Training: Empirical Evidence from Master of Business Administration Programs in Vietnam

    Science.gov (United States)

    Pham, Nga T. P.; Segers, Mien S. R.; Gijselaers, Wim H.

    2013-01-01

    Practical application of newly gained knowledge and skills, also referred to as transfer of training, is an issue of great concern in training issues generally and in Master of Business Administration (MBA) programs particularly. This empirical study examined the influence of the trainees' work environment on their transfer of training, taking…

  17. The Effect of Administrative Pay and Local Property Taxes on Student Achievement Scores: Evidence from New Jersey Public Schools

    Science.gov (United States)

    Mensah, Yaw M.; Schoderbek, Michael P.; Sahay, Savita P.

    2013-01-01

    We theorized that student test score performance will be positively related to the percentage of school district revenues raised from local taxes and with salary levels of school district administrators. Using both fixed and random effects panel analyses, we examine data for 217 Kindergarten-to-Grade 12 school districts in New Jersey for the years…

  18. The Influence of Classroom Management, Administrative Support, Parental Involvement, and Economic Factors on the Retention of Novice Teachers

    Science.gov (United States)

    Dwyer, Katrina Moody

    2013-01-01

    The purpose of this study was to examine the impact of selected factors upon the intent of novice teachers to remain in the classroom. Teachers are leaving the profession in numbers that have prompted significant concern among policymakers and administrators. Many qualified college students are not considering the field of education as a potential…

  19. Arthritis Quality Indicators for the Veterans Administration: Implications for Electronic Data Collection, Storage Format, Quality Assessment, and Clinical Decision Support

    OpenAIRE

    Williams, Carl A.; Mosley-Williams, Angelia D.; Overhage, J. Marc

    2007-01-01

    The Veterans Administration (VA) uses information technology and performance measures to improve quality and efficiency. The VA stores all patient data electronically. Manual quality assessment audits are performed every three months. They are time consuming and expensive. Automated reviews would be more efficient. But the patient records are neither sufficiently coded nor structured to allow for full machine interpretability.

  20. Developing Evidence-Based Care Standards and a Decision-Making Support System for Pain Management.

    Science.gov (United States)

    Feng, Rung-Chuang; Chang, Polun

    2016-01-01

    Pain is a crucial sign and symptom in hospitalised patients. This paper describes how a medical centre created a knowledge-based, computerised pain management decision-making process to support nurses in personalising preventive interventions based on patient requirements. PMID:27332393

  1. Empirically Supported Psychotherapy in Social Work Training Programs: Does the Definition of Evidence Matter?

    Science.gov (United States)

    Bledsoe, Sarah E.; Weissman, Myrna M.; Mullen, Edward J.; Ponniah, Kathryn; Gameroff, Marc J.; Verdeli, Helen; Mufson, Laura; Fitterling, Heidi; Wickramaratne, Priya

    2007-01-01

    Objectives: A national survey finds that 62% of social work programs do not require didactic and clinical supervision in any empirically supported psychotherapy (EST). The authors report the results of analysis of national survey data using two alternative classifications of EST to determine if the results are because of the definition of EST used…

  2. The Influence of Social and Organizational Support on Transfer of Training: Evidence from Thailand

    Science.gov (United States)

    Homklin, Tassanee; Takahashi, Yoshi; Techakanont, Kriengkrai

    2014-01-01

    This study focused on integrating social and organizational support as moderators into the main analysis model of the relationship between learning -- specifically perceived knowledge retained -- and its transfer as perceived by participants. We used hierarchical regression analysis in order to test our hypotheses. Results were generally…

  3. Risk Aversion and Support for Merit Pay: Theory and Evidence from Minnesota's Q Comp Program

    Science.gov (United States)

    Nadler, Carl; Wiswall, Matthew

    2011-01-01

    Recent research attributes the lack of merit pay in teaching to the resistance of teachers. This article examines whether the structure of merit pay affects the types of teachers who support it. We develop a model of the relative utility teachers receive from merit pay versus the current fixed schedule of raises. We show that if teachers are risk…

  4. Facilitating the implementation of evidence-based practice through contextual support and nursing leadership

    OpenAIRE

    Kueny, Angela

    2015-01-01

    Angela Kueny,1 Leah L Shever,2 Melissa Lehan Mackin,3 Marita G Titler4 1Luther College, Decorah, IA, 2The University of Michigan Hospital and Health Center, Ann Arbor, MI, 3University of Iowa College of Nursing, Iowa City, IA, 4University of Michigan School of Nursing, Ann Arbor, MI, USA Background/purpose: Nurse managers (NMs) play an important role promoting evidence-based practice (EBP) on clinical units within hospitals. However, there is a dearth of research focused on NM perspectives a...

  5. Child Benefit Support and Method of Payment: Evidence from a Randomized Experiment in Belgium

    OpenAIRE

    Marieke Huysentruyt; Eva Lefevere

    2010-01-01

    We present evidence from a randomized Öeld experiment explictly designed to shed light on the role of standard information, goal framed information, and decision task complexity in individualsí choice of payment method. The experiment encouraged 19,707 Clients of the Belgian National O¢ ce for Family BeneÖts to change from benefit payment by check to payment via direct transfer via a one-time mailing. The direct mailings multiplied the switching rate of these treated individuals (relative to ...

  6. Monitoring and supervision of the Support Centre for Family Health (NASF) in an administrative region of the Distrito Federal using analysis of interviews

    OpenAIRE

    Michelline Ribeiro Rodriguez; Mônica Alvares Leão; Nubia Katia Teixeira de Souza

    2014-01-01

    Objective: To analyze the monitoring and supervision of the actions of the Support Centre for Family Health (NASF) in an administrative region of Distrito Federal (DF), Riacho Fundo II. Methods: Semi-structured interviews were conducted with five NASF managers who were responsible for its management at the Regional, District, and Federal levels. These interviews were recorded, transcribed, and analyzed according to Bardin’s Content Analysis Method. Results: There is no registration system tha...

  7. Scrape-off layer turbulence in TCV: evidence in support of stochastic modelling

    Czech Academy of Sciences Publication Activity Database

    Theodorsen, A.; Garcia, O.E.; Horáček, Jan; Kube, R.; Pitts, R.A.

    2016-01-01

    Roč. 58, č. 4 (2016), s. 044006. ISSN 0741-3335 R&D Projects: GA ČR(CZ) GAP205/12/2327 Institutional support: RVO:61389021 Keywords : turbulence * intermittency * transport * scrape-off layer * tcv * plasma * tokamak Subject RIV: BL - Plasma and Gas Discharge Physics Impact factor: 2.186, year: 2014 http://iopscience.iop.org/article/10.1088/0741-3335/58/4/044006/meta

  8. Evaluating the role of postconstruction support in sustaining drinking water projects : Evidence from Peru

    OpenAIRE

    Prokopy, L. S.; Thorsten, R.; Bakalian, A.; Wakeman, W.

    2008-01-01

    This article assesses the impact of postconstruction support (PCS) on the sustainability of participatory, demand-driven rural water projects in the Cuzco region of Peru. This Study evaluates ninety-nine villages from two water supply schemes-projects built under a social investment fund program and those built under a nongovernmental program funded by the Swiss government. Overall, the study finds that the projects are performing very well. Multivariate regression analysis suggests that hous...

  9. Replication Study Supports Evidence for Linkage to 9p24 in Obsessive-Compulsive Disorder

    OpenAIRE

    Willour, Virginia L.; Yao Shugart, Yin; Samuels, Jack; GRADOS, MARCO; Cullen, Bernadette; Bienvenu III, O. Joseph; Wang, Ying(School of Physics, Shandong University, Jinan, 250100, PR China); Liang, Kung-Yee; Valle, David; Hoehn-Saric, Rudolf; Riddle, Mark; Nestadt, Gerald

    2004-01-01

    Obsessive-compulsive disorder (OCD) is a severe psychiatric illness that is characterized by intrusive and senseless thoughts and impulses (obsessions) and by repetitive behaviors (compulsions). Family, twin, and segregation studies support the presence of both genetic and environmental susceptibility factors, and the only published genome scan for OCD identified a candidate region on 9p24 at marker D9S288 that met criteria for suggestive significance (Hanna et al. 2002). In an attempt to rep...

  10. Breastfeeding and child cognitive outcomes: Evidence from a hospital-based breastfeeding support policy

    OpenAIRE

    Del Bono, Emilia; Rabe, Birgitta

    2012-01-01

    This paper estimates the causal effects of breastfeeding on early child development using exogenous variation in breastfeeding support policies across UK maternity hospitals. Based on data from the Millennium Cohort Study, we find that mothers giving birth in hospitals where such policies are implemented are between 8 and 9 percentage points more likely to breastfeed exclusively at 4 and 8 weeks than mothers who give birth in other hospitals. The effect of breastfeeding are found to be large ...

  11. Measuring change in health care equity using small area administrative data – evidence from the English NHS 2001-8

    OpenAIRE

    Richard Cookson; Mauro Laudicella; Paolo Li Donni

    2011-01-01

    This study developed a method for measuring change in socio-economic equity in health care utilisation using small area level administrative data. Our method provides more detailed information on utilisation than survey data but only examines socio-economic differences between neighbourhoods rather than individuals. The context was the English NHS from 2001 to 2008, a period of accelerated expenditure growth and pro-competition reform. Hospital records for all adults receiving non-emergency h...

  12. Neuroimaging Evidence of Altered Fronto-Cortical and Striatal Function after Prolonged Cocaine Self-Administration in the Rat

    OpenAIRE

    Gozzi, Alessandro; Tessari, Michela; Dacome, Lisa; Agosta, Federica; Lepore, Stefano; Lanzoni, Anna; Cristofori, Patrizia; Merlo Pich, Emilio; Corsi, Mauro; Bifone, Angelo

    2011-01-01

    Abstract Cocaine addiction is often modeled in experimental paradigms where rodents learn to self-administer the drug. However, the extent to which these models replicate the functional alterations observed in clinical neuroimaging studies of cocaine addiction remains unknown. We used Magnetic Resonance Imaging (MRI) to assess basal and evoked brain function in rats subjected to a prolonged, extended-access cocaine self-administration scheme. Specifically, we measured basal cere...

  13. Methodological aspects and empirical evidence in the use of administrative sources to estimate price dynamics in external trade

    OpenAIRE

    Paola Anitori; Carlo De Gregorio

    2011-01-01

    This paper explores the possibility to widen the current offer of unit value and price indicators in external trade throughout a more intensive and efficient use of the available administrative sources. In particular, it firstly overviews the opportunities offered by a fuller exploitation of custom records linkage to other sources, such as business registers. Secondly, it presents a suitable conceptual and methodological framework for the estimates of price indicators based on custom records ...

  14. Further Evidence in Support of the Universal Nilpotent Grammatical Computational Paradigm of Quantum Physics

    International Nuclear Information System (INIS)

    Further evidence is presented in favour of the computational paradigm, conceived and constructed by Rowlands and Diaz, as detailed in Rowlands' book Zero to Infinity (2007), and in particular the authors' paper 'The Grammatical Universe: the Laws of Thermodynamics and Quantum Entanglement'. The paradigm, which has isomorphic group and algebraic quantum mechanical language interpretations, not only predicts the well-established facts of quantum physics, the periodic table, chemistry / valence and of molecular biology, whose understanding it extends; it also provides an elegant, simple solution to the unresolved quantum measurement problem. In this fundamental paradigm, all the computational constructs / predictions that emerge, follow from the simple fact, that, as in quantum mechanics, the wave function is defined only up to an arbitrary fixed phase. This fixed phase provides a simple physical understanding of the quantum vacuum in quantum field theory, where only relative phases, known to be able to encode 3+1 relativistic space-time geometries, can be measured. It is the arbitrary fixed measurement standard, against which everything that follows is to be measured, even though the standard itself cannot be, since nothing exists against which to measure it. The standard, as an arbitrary fixed reference phase, functions as the holographic basis for a self-organized universal quantum process of emergent novel fermion states of matter where, following each emergence, the arbitrary standard is re-fixed anew so as to provide a complete history / holographic record or hologram of the current fixed past, advancing an unending irreversible evolution, such as is the evidence of our senses. The fermion states, in accord with the Pauli exclusion principle, each correspond to a unique nilpotent symbol in the infinite alphabet (which specifies the grammar in this nilpotent universal computational rewrite system (NUCRS) paradigm); and the alphabet, as Hill and Rowlands

  15. Further Evidence in Support of the Universal Nilpotent Grammatical Computational Paradigm of Quantum Physics

    Science.gov (United States)

    Marcer, Peter J.; Rowlands, Peter

    2010-12-01

    Further evidence is presented in favour of the computational paradigm, conceived and constructed by Rowlands and Diaz, as detailed in Rowlands' book Zero to Infinity (2007) [2], and in particular the authors' paper `The Grammatical Universe: the Laws of Thermodynamics and Quantum Entanglement' [1]. The paradigm, which has isomorphic group and algebraic quantum mechanical language interpretations, not only predicts the well-established facts of quantum physics, the periodic table, chemistry / valence and of molecular biology, whose understanding it extends; it also provides an elegant, simple solution to the unresolved quantum measurement problem. In this fundamental paradigm, all the computational constructs / predictions that emerge, follow from the simple fact, that, as in quantum mechanics, the wave function is defined only up to an arbitrary fixed phase. This fixed phase provides a simple physical understanding of the quantum vacuum in quantum field theory, where only relative phases, known to be able to encode 3+1 relativistic space-time geometries, can be measured. It is the arbitrary fixed measurement standard, against which everything that follows is to be measured, even though the standard itself cannot be, since nothing exists against which to measure it. The standard, as an arbitrary fixed reference phase, functions as the holographic basis for a self-organized universal quantum process of emergent novel fermion states of matter where, following each emergence, the arbitrary standard is re-fixed anew so as to provide a complete history / holographic record or hologram of the current fixed past, advancing an unending irreversible evolution, such as is the evidence of our senses. The fermion states, in accord with the Pauli exclusion principle, each correspond to a unique nilpotent symbol in the infinite alphabet (which specifies the grammar in this nilpotent universal computational rewrite system (NUCRS) paradigm); and the alphabet, as Hill and Rowlands

  16. Where is the evidence supporting public service announcements to eliminate mental illness stigma?

    Science.gov (United States)

    Corrigan, Patrick W

    2012-01-01

    Advocates and social marketers have used substantial resources to develop public service announcements (PSAs) as a lead strategy in public education and awareness campaigns meant to eliminate stigma associated with mental illness. Evaluations of PSAs are needed to determine whether this is a good investment. The author notes that very few studies have been reported in the peer-reviewed medical and psychological research literature addressing this question. Reports of government contractors suggest that PSAs have some effect as measured by population penetration, but such data provide no meaningful evidence about the impact of PSAs, such as real-world change in prejudicial attitudes and discriminatory behaviors. The author considers reasons for the limited impact of PSAs and proposes that social marketing campaigns could enhance their impact by targeting local groups. PMID:22227764

  17. American Society for Microbiology resources in support of an evidence-based approach to teaching microbiology.

    Science.gov (United States)

    Merkel, Susan M

    2016-08-01

    Numerous national reports have addressed the need for changing how science courses in higher education are taught, so that students develop a deeper understanding of critical concepts and the analytical and cognitive skills needed to address future challenges. This review presents some evidence-based approaches to curriculum development and teaching. Results from discipline-based education research indicate that it is critically important for educators to formulate learning goals, provide frequent and authentic assessments and actively engage students in their learning. Professional societies can play a role in helping to put these changes into practice. To this end, the American Society for Microbiology has developed a number of educational programs and resources, which are described here to encourage the implementation of student-centered learning in microbiology education. PMID:27412169

  18. Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris.

    LENUS (Irish Health Repository)

    Bowes, John

    2011-06-01

    There is great interest in the identification of genetic factors that differentiate psoriatic arthritis (PsA) from psoriasis vulgaris (PsV), as such discoveries could lead to the identification of distinct underlying aetiological pathways. Recent studies identified single nucleotide polymorphisms (SNPs) in the interleukin 13 (IL-13) gene region as risk factors for PsV. Further investigations in one of these studies found the effect to be primarily restricted to PsA, thus suggesting the discovery of a specific genetic risk factor for PsA. Given this intriguing evidence, association to this gene was investigated in large collections of PsA and PsV patients and healthy controls.

  19. Synthetic Cannabinoids-Further Evidence Supporting the Relationship Between Cannabinoids and Psychosis.

    Science.gov (United States)

    Fattore, Liana

    2016-04-01

    Consumption of synthetic mind-altering compounds, also known as "new psychoactive substances," is increasing globally at an alarming rate. Synthetic cannabinoids (SCs) are among the most commonly used new psychoactive substances. They are usually purchased as marijuana-like drugs, marketed as herbal blends and perceived as risk-free by inexperienced users. Yet, contrary to Δ(9)-tetrahydrocannabinol, SCs may lead to severe health consequences, including anxiety, tachycardia, hallucinations, violent behavior, and psychosis. This review focuses on the latest (2010-2015) evidence of psychotic symptoms induced by ingestion of products containing SCs. Reports suggesting that SCs may either exacerbate previously stable psychotic symptoms (in vulnerable individuals) or trigger new-onset psychosis (in individuals with no previous history of psychosis) are reviewed. Pharmacology and toxicology of these compounds are discussed, with particular reference to their psychoactive effects. PMID:26970364

  20. What is the evidence to support the use of therapeutic gardens for the elderly?

    Science.gov (United States)

    Detweiler, Mark B; Sharma, Taral; Detweiler, Jonna G; Murphy, Pamela F; Lane, Sandra; Carman, Jack; Chudhary, Amara S; Halling, Mary H; Kim, Kye Y

    2012-06-01

    Horticulture therapy employs plants and gardening activities in therapeutic and rehabilitation activities and could be utilized to improve the quality of life of the worldwide aging population, possibly reducing costs for long-term, assisted living and dementia unit residents. Preliminary studies have reported the benefits of horticultural therapy and garden settings in reduction of pain, improvement in attention, lessening of stress, modulation of agitation, lowering of as needed medications, antipsychotics and reduction of falls. This is especially relevant for both the United States and the Republic of Korea since aging is occurring at an unprecedented rate, with Korea experiencing some of the world's greatest increases in elderly populations. In support of the role of nature as a therapeutic modality in geriatrics, most of the existing studies of garden settings have utilized views of nature or indoor plants with sparse studies employing therapeutic gardens and rehabilitation greenhouses. With few controlled clinical trials demonstrating the positive or negative effects of the use of garden settings for the rehabilitation of the aging populations, a more vigorous quantitative analysis of the benefits is long overdue. This literature review presents the data supporting future studies of the effects of natural settings for the long term care and rehabilitation of the elderly having the medical and mental health problems frequently occurring with aging. PMID:22707959

  1. What Is the Evidence to Support the Use of Therapeutic Gardens for the Elderly?

    Science.gov (United States)

    Detweiler, Mark B.; Sharma, Taral; Detweiler, Jonna G.; Murphy, Pamela F.; Lane, Sandra; Carman, Jack; Chudhary, Amara S.; Halling, Mary H.

    2012-01-01

    Horticulture therapy employs plants and gardening activities in therapeutic and rehabilitation activities and could be utilized to improve the quality of life of the worldwide aging population, possibly reducing costs for long-term, assisted living and dementia unit residents. Preliminary studies have reported the benefits of horticultural therapy and garden settings in reduction of pain, improvement in attention, lessening of stress, modulation of agitation, lowering of as needed medications, antipsychotics and reduction of falls. This is especially relevant for both the United States and the Republic of Korea since aging is occurring at an unprecedented rate, with Korea experiencing some of the world's greatest increases in elderly populations. In support of the role of nature as a therapeutic modality in geriatrics, most of the existing studies of garden settings have utilized views of nature or indoor plants with sparse studies employing therapeutic gardens and rehabilitation greenhouses. With few controlled clinical trials demonstrating the positive or negative effects of the use of garden settings for the rehabilitation of the aging populations, a more vigorous quantitative analysis of the benefits is long overdue. This literature review presents the data supporting future studies of the effects of natural settings for the long term care and rehabilitation of the elderly having the medical and mental health problems frequently occurring with aging. PMID:22707959

  2. Communicating Program Outcomes to Encourage Policymaker Support for Evidence-Based State Tobacco Control

    Directory of Open Access Journals (Sweden)

    Allison M. Schmidt

    2014-12-01

    Full Text Available Tobacco use, the leading cause of preventable death in the U.S., can be reduced through state-level tobacco prevention and cessation programs. In the absence of research about how to communicate the need for these programs to policymakers, this qualitative study aimed to understand the motivations and priorities of policymakers in North Carolina, a state that enacted a strong tobacco control program from 2003–2011, but drastically reduced funding in recent years. Six former legislators (three Democrats, three Republicans and three lobbyists for health organizations were interviewed about their attitudes towards tobacco use, support of state-funded programs, and reactions to two policy briefs. Five themes emerged: (1 high awareness of tobacco-related health concerns but limited awareness of program impacts and funding, (2 the primacy of economic concerns in making policy decisions, (3 ideological differences in views of the state’s role in tobacco control, (4 the impact of lobbyist and constituent in-person appeals, and (5 the utility of concise, contextualized data. These findings suggest that building relationships with policymakers to communicate ongoing program outcomes, emphasizing economic data, and developing a constituent advocacy group would be valuable to encourage continued support of state tobacco control programs.

  3. Understanding the Concept of Fit-For-Purpose Land Administration in Support of the Post 2015 Global Agenda

    DEFF Research Database (Denmark)

    Enemark, Stig

    2015-01-01

    top-end technical solutions and high accuracy surveys. Of course, such flexibility allows for land administration systems to be incrementally improved over time. This paper unfolds the Fit-For-Purpose concept by analysing the three core components: • The spatial framework (large scale land parcel...... enable security of land rights for all and to cover all land as a basis for land valuation and land use control. At the outset, the systems may vary from being very simplistic in some (rural) areas of the country while other (densely populated) areas are covered by more accurate and legally complete...

  4. Does money matter for mental health? Evidence from the Child Support Grants in Johannesburg, South Africa.

    Science.gov (United States)

    Plagerson, Sophie; Patel, Vikram; Harpham, Trudy; Kielmann, Karina; Mathee, Angela

    2011-01-01

    Globally, the poor are consistently at greater risk of suffering from depression and anxiety. Yet in resource-poor countries, mental health remains a neglected topic. This interdisciplinary study explored the potential for a poverty alleviation programme to contribute to breaking the vicious cycle between poverty and common mental disorders (CMD). Quantitatively, beneficiaries of a cash-transfer programme were found to have a lower risk of CMD. Qualitative interviews indicated that Child Support Grants acted as a psychological safety net, but that negative stereotypes of grant recipients could detract from the positive mental health outcomes of the grants. It was concluded that poverty alleviation programmes such as cash transfers could have both positive and negative impacts on mental health. In order to achieve mental health benefits for programme beneficiaries, aspects of programme design and implementation that promote mental health should be enhanced and aspects detrimental to mental health modified. PMID:20938853

  5. The California Health Policy Research Program - supporting policy making through evidence and responsive research.

    Science.gov (United States)

    Roby, Dylan H; Jacobs, Ken; Kertzner, Alex E; Kominski, Gerald F

    2014-08-01

    This article explores the creation, design, and execution of a university-based collaboration to provide responsive research and evidence to a group of diverse health care, labor, and consumer stakeholders through convening a funded series of deliberative meetings, research briefs, peer-reviewed journal articles, ad hoc data analyses, and policy analyses. Funded by the California Endowment, the California Health Policy Research Program was created by researchers at the University of California, Berkeley Center for Labor Research and Education, and the UCLA Center for Health Policy Research. The collaboration not only allowed new research and analyses to be used by stakeholders and policy makers in decision making but also allowed university researchers to receive input on the important health policy issues of the day. The guidance of stakeholders in the research and policy analysis process was vital in driving meaningful results during an important time in health policy making in California. The manuscript discusses lessons learned in building relationships with stakeholders; meeting research and analytic needs; engaging stakeholders and policy makers; building capacity for quick-turnaround data collection and analysis, dissemination and publication; and maintaining the collaboration. PMID:24842967

  6. Ontology supported system for searching evidence of wild animals trafficking in social network posts

    Directory of Open Access Journals (Sweden)

    Rafael da Silva Carrasco

    2014-04-01

    Full Text Available O comércio ilegal de animais silvestres é uma das atividades criminais mais lucrativas da atualidade. No Brasil, a grande variedade de fauna nativa tem alimentado o mercado ilegal, o que gera sérias implicações ambientais e sociais. A luta contra o comércio ilegal de animais silvestres é crucial para ajudar a proteger os recursos naturais e evitar a disseminação de outras formas de crime. Esse tipo de comércio ilegal usa cada vez mais, a internet para realizar suas atividades. A fim de combater tal crime, um sistema automático de monitorização é essencial. No entanto, para realizar essa tarefa de forma eficaz, o sistema deve ser capaz de analisar as mensagens trocadas durante essa prática. Para isso, é necessário o conhecimento dos conceitos e relações que ocorrem nesse domínio. Este artigo apresenta um sistema multiagente apoiado por ontologia de domínio e frames semânticos para buscar evidências de comércio ilegal de animais silvestres. No artigo, é mostrado como o sistema pode ser usado na tarefa de rastreamento do comércio ilegal de animais silvestres, além de apresentar os resultados da aplicação do sistema em um pequeno corpus.

  7. 动物卫生监督行政证据与刑事司法证据的衔接%The Conversion of Animal Health Supervision Administrative Evidences with Criminal Justice Evidences

    Institute of Scientific and Technical Information of China (English)

    虞鹃; 邴国霞; 景小金

    2014-01-01

    “The Explanations on Some Issues on the Applicable Laws in Handling Food Safety Criminal Cases by The Supreme People's Court and The Supreme People's Procuratorate”has founded a good base for the animal health supervision and law enforcement against food hygiene criminal cases endangering food safety. But in practice,there are still many places worthy to be discussed during conversion of the animal health supervision administrative evidences with criminal justice evidences and the principles to be followed during the conversion process. In this article,the author has clariifed the current main problems of the animal health supervision administrative evidence conversion with criminal justice evidence,and gives a brief analysis from main collecting body and the evidence transforming rules .%《最高人民法院、最高人民检察院关于办理危害食品安全刑事案件适用法律若干问题的解释》为动物卫生监督执法打击危害食品卫生安全刑事案件奠定了良好基础。但是在实践操作中,动物卫生监督行政证据能否与刑事司法证据进行转化,以及在转化过程中应该遵循哪些规则?仍有许多值得探讨的地方。本文梳理了当前动物卫生监督行政证据与刑事司法证据衔接存在的主要问题,并从收集主体、证据转化规则上进行了粗略的探讨。

  8. 78 FR 59654 - Possible Models for the Administration and Support of Discipline-Specific Guidance Groups for...

    Science.gov (United States)

    2013-09-27

    ... Discipline- Specific Guidance Groups for Forensic Science AGENCY: National Institute of Standards and... Understanding (MOU) with the intent of supporting the strengthening of forensic science in the United States... of forensic science by improving coordination across a broad range of forensic science...

  9. The "Virtual Face" of Distance Learning at Public Colleges and Universities: What Do Websites Reveal about Administrative Student Support Services?

    Science.gov (United States)

    Jones, Stephanie J.; Meyer, Katrina A.

    2012-01-01

    This study investigated how higher education institutions support their distance learning initiatives through their institutional websites--their "virtual face." The population was 40 institutions, of which 10 each were doctoral/research, master, baccalaureate, and community college, located in 40 different states. Using a researcher-developed…

  10. New evidence of feathers in the Crato Formation supporting a reappraisal on the presence of Aves

    Directory of Open Access Journals (Sweden)

    Juliana M. Sayão

    2011-03-01

    Full Text Available The preservation of delicate structures such as feathers is very rare in the paleontological record, due to the fragility of their components. Fossil feathers have been reported from approximately 50 deposits around the world, from the Late Jurassic to the Pleistocene. In Brazil initial findings consisted of a primary feather of a large bird found in the Tremembé Formation. Other occurrences are preserved in the Crato Formation, where several symmetrical and one single asymmetrical feather was found. Based on three new specimens and reassessing further feather occurrences we cannot confirm the presence of volant Aves in this deposit. The presence of an asymmetrical feather without barbules and hooks hints at the previous existence of a flightless animal within this deposit, possibly a flightlessness bird or a non-avian theropod. Conversely, the presence of a feather from morphotype II present in Tyrannosauroidea, Compsognathidae, Therizinosauroidea and Dromeosauridae, points to a non-theropod origin. Since there are no confirmed records of birds and other feathered archosaurs in the region to date, more evidence is required to identify the animal from which these structures originated.A fossilização de estruturas de revestimento delicadas como as penas constitui um processo extremamente raro, principalmente pela fragilidade de seus componentes. São conhecidos apenas cinquenta depósitos com esta natureza de registro (do Jurássico ao Terciário. No Brasil a primeira referência data de 1916, descrevendo uma pena de vôo com características plumáceas da Formação Tremembé (Bacia de Taubaté. Outras evidências, são provenientes dos calcários laminados da Formação Crato, apresentando registros de penas assimétricas e apenas uma simétrica. Com base em novos achados e reavaliando penas previamente descritas, verificou-se que não se pode afirmar a presença de Aves voadoras nestes depósitos. Isto se deve a ausência de estruturas

  11. Mitochondrial DNA evidence supports northeast Indian origin of the aboriginal Andamanese in the Late Paleolithic

    Institute of Scientific and Technical Information of China (English)

    Hua-Wei Wang; Bikash Mitra; Tapas Kumar Chaudhuri; Malliya gounder Palanichamy; Qing-Peng Kong; Ya-Ping Zhang

    2011-01-01

    In view of the geographically closest location to Andaman archipelago,Myanmar was suggested to be the origin place of aboriginal Andamanese.However,for lacking any genetic information from this region,which has prevented to resolve the dispute on whether the aboriginal Andamanese were originated from mainland India or Myanmar.To solve this question and better understand the origin of the aboriginal Andamanese,we screened for haplogroups M31(from which Andaman-specific lineage M31a1 branched off)and M32 among 846mitochondrial DNAs(mtDNAs)sampled across Myanmar.As a result,two Myanmar individuals belonging to haplogroup M31 were identified,and completely sequencing the entire mtDNA genomes of both samples testified that the two M31 individuals observed in Myanmar were probably attributed to the recent gene flow from northeast India populations.Since no root lineages of haplogroup M31 or M32 were observed in Myanmar,it is unlikely that Myanmar may serve as the source place of the aboriginal Andamanese.To get further insight into the origin of this unique population,the detailed phylogenetic and phylogeographic analyses were performed by including additional 7 new entire mtDNA genomes and 113 M31 mtDNAs pinpointed from South Asian populations,and the results suggested that Andaman-specific M31a1 could in fact trace its origin to northeast India.Time estimation results further indicated that the Andaman archipelago was likely settled by modern humans from northeast India via the land-bridge which connected the Andaman archipelago and Myanmar around the Last Glacial Maximum(LGM),a scenario in well agreement with the evidence from linguistic and palaeoclimate studies.

  12. Mobile DNA and the TE-Thrust hypothesis: supporting evidence from the primates

    Directory of Open Access Journals (Sweden)

    Oliver Keith R

    2011-05-01

    Full Text Available Abstract Transposable elements (TEs are increasingly being recognized as powerful facilitators of evolution. We propose the TE-Thrust hypothesis to encompass TE-facilitated processes by which genomes self-engineer coding, regulatory, karyotypic or other genetic changes. Although TEs are occasionally harmful to some individuals, genomic dynamism caused by TEs can be very beneficial to lineages. This can result in differential survival and differential fecundity of lineages. Lineages with an abundant and suitable repertoire of TEs have enhanced evolutionary potential and, if all else is equal, tend to be fecund, resulting in species-rich adaptive radiations, and/or they tend to undergo major evolutionary transitions. Many other mechanisms of genomic change are also important in evolution, and whether the evolutionary potential of TE-Thrust is realized is heavily dependent on environmental and ecological factors. The large contribution of TEs to evolutionary innovation is particularly well documented in the primate lineage. In this paper, we review numerous cases of beneficial TE-caused modifications to the genomes of higher primates, which strongly support our TE-Thrust hypothesis.

  13. Testing Basic Laws of Gravitation - Are Our Postulates on Dynamics and Gravitation Supported by Experimental Evidence?

    Science.gov (United States)

    Lämmerzahl, Claus

    Gravity is the most fundamental interaction; it not only describes a particular interaction between matter, but also encompasses issues such as the notion of space and time, the role of the observer, and the relativistic measurement process. Gravity is geometry and, in consequence, allows the existence of horizons and black holes, nontrivial topologies, a cosmological big bang, time-travel, warp drive, and other phenomena unknown in nonrelativistic physics. Here we present the experimental basis of General Relativity, addressing its foundations encoded in the Einstein Equivalence Principle and its predictions in the weak and strong gravity regimes. We discuss several approaches in the search to reveal an influence of the much sought-after quantum theory of gravity. We emphasize assumptions underlying the dynamics - for example, Newton's axioms and conservation laws - and the current extent to which they are supported by experiment. We discuss conditions under which gravity can be transformed away locally, and examine higher order time derivatives in the equations of motion.

  14. RAPE SUPPORTIVE ATTITUDE SCALE: FIRST EVIDENCE ON ITS RELIABILITY AND VALIDITY IN THE SALVADORIAN SAMPLES

    Directory of Open Access Journals (Sweden)

    Juan Carlos Sierra

    2007-11-01

    Full Text Available The tolerant attitudes towards sexual violence on women are important risk factor which should be considered whileexplaining this type of aggressive behaviour. One of the instruments to evaluate these attitudes is Rape SupportiveAttitude Scale (RSAS by Lottes. The scale has showed good indexes of reliability and validity in both American andSpanish university students. The purpose of the study is to explore the psychometric characteristics in El Salvador asit has been applied together with the Double Standard Scale by Caron, Davis, Haltelman and Stickle (1993 and Crowneand Marlowe (1960 Social Desirability Scale in two samples which consisted of 505 and 1499 students, respectively.The results indicate that the one-dimensional structure of the scale stays stable in the two samples reaching thecoefficients of internal consistence higher than .80, although it includes two items which requires to be reviewed infuture studies. Concerning the validity, the RSAS differentiates men and women in these types of attitudes and showssignificant positive correlation with double sexual standard.

  15. Evidence to support the use of vildagliptin monotherapy in the treatment of type 2 diabetes mellitus

    Directory of Open Access Journals (Sweden)

    Dejager S

    2012-05-01

    Full Text Available Sylvie Dejager,1 Anja Schweizer,2 James E Foley31Novartis Pharma SAS, Rueil Malmaison, France; 2Novartis Pharma AG, Basel, Switzerland; 3Novartis Pharmaceuticals Corporation, East Hanover, NJ, USAAbstract: The efficacy and safety of the dipeptidyl peptidase-4 inhibitor, vildagliptin, as monotherapy have been widely confirmed in a large body of clinical studies of up to 2 years’ duration in various populations with type 2 diabetes mellitus. This paper reviews the data supporting the use of vildagliptin in monotherapy. Consideration based on baseline glycated hemoglobin levels and age is given to patient segments where metformin is not appropriate. In addition, although prediabetes is not an indication, this manuscript briefly reviews some of the existing data showing that the mechanisms at work in diabetic populations are active in patients currently classified as prediabetic, with impaired glucose tolerance or impaired fasting glucose. Finally, the rationale for vildagliptin dosing frequency in monotherapy is discussed. In summary, this review aims to define where in community practice the use of vildagliptin as monotherapy is most desirable, focusing on segments of the population with type 2 diabetes mellitus that might receive the greatest benefit from vildagliptin in the management of their disease.Keywords: vildagliptin, type 2 diabetes, dipeptidyl peptidase-4 inhibitors, monotherapy, elderly

  16. Chemiluminescence evidence supporting the selective role of ligands in the permanganate oxidation of micropollutants.

    Science.gov (United States)

    Roderick, Mark S; Adcock, Jacqui L; Terry, Jessica M; Smith, Zoe M; Parry, Samuel; Linton, Stuart M; Thornton, Megan T; Barrow, Colin J; Francis, Paul S

    2013-10-10

    The selective increase in the oxidation rate of certain organic compounds with permanganate in the presence of environmental "ligands" and reduced species has been ascribed to the different reactivity of the target compounds toward Mn(III), which bears striking similarities to recent independent investigations into the use of permanganate as a chemiluminescence reagent. In spite of the importance of Mn(III) in the light-producing pathway, the dependence of the oxidation mechanism for any given compound on this intermediate could not be determined solely through the emission intensity. However, target compounds susceptible to single-electron oxidation by Mn(III) (such as bisphenol A and triclosan) can be easily distinguished by the dramatic increase in chemiluminescence intensity when a permanganate reagent containing high, stable concentrations of Mn(III) is used. The differences are accentuated under the low pH conditions that favor the chemiluminescence emission due to the greater reactivity of Mn(III) and the greater influence of complexing agents. This study supports the previously postulated selective role of ligands and reducing agents in permanganate oxidations and demonstrates a new approach to explore the chemistry of environmental manganese redox processes. PMID:24050380

  17. Field evidence that ecosystem service projects support biodiversity and diversify options.

    Science.gov (United States)

    Goldman, Rebecca L; Tallis, Heather; Kareiva, Peter; Daily, Gretchen C

    2008-07-01

    Ecosystem service approaches to conservation are being championed as a new strategy for conservation, under the hypothesis that they will broaden and deepen support for biodiversity protection. Where traditional approaches focus on setting aside land by purchasing property rights, ecosystem service approaches aim to engage a much wider range of places, people, policies, and financial resources in conservation. This is particularly important given projected intensification of human impacts, with rapid growth in population size and individual aspirations. Here we use field research on 34 ecosystem service (ES) projects and 26 traditional biodiversity (BD) projects from the Western Hemisphere to test whether ecosystem service approaches show signs of realizing their putative potential. We find that the ES projects attract on average more than four times as much funding through greater corporate sponsorship and use of a wider variety of finance tools than BD projects. ES projects are also more likely to encompass working landscapes and the people in them. We also show that, despite previous concern, ES projects not only expand opportunities for conservation, but they are no less likely than BD projects to include or create protected areas. Moreover, they do not draw down limited financial resources for conservation but rather engage a more diverse set of funders. We also found, however, that monitoring of conservation outcomes in both cases is so infrequent that it is impossible to assess the effectiveness of either ES or BD approaches. PMID:18591667

  18. Genetic Evidence Supports the Multiethnic Character of Teopancazco, a Neighborhood Center of Teotihuacan, Mexico (AD 200-600)

    Science.gov (United States)

    Álvarez-Sandoval, Brenda A.; Manzanilla, Linda R.; González-Ruiz, Mercedes; Malgosa, Assumpció; Montiel, Rafael

    2015-01-01

    Multiethnicity in Teopancazco, Teotihuacan, is supported by foreign individuals found in the neighborhood center as well as by the diversity observed in funerary rituals at the site. Studies of both stable and strontium isotopes as well as paleodietary analysis, suggest that the population of Teopancazco was composed by three population groups: people from Teotihuacan, people from nearby sites (Tlaxcala-Hidalgo-Puebla), and people from afar, including the coastal plains. In an attempt to understand the genetic dynamics in Teopancazco we conducted an ancient DNA (aDNA) analysis based on mtDNA. Our results show that the level of genetic diversity is consistent with the multiethnicity phenomenon at the neighborhood center. Levels of genetic diversity at different time periods of Teopancazco’s history show that multiethnicity was evident since the beginning and lasted until the collapse of the neighborhood center. However, a PCA and a Neighbor-Joining tree suggested the presence of a genetically differentiated group (buried at the Transitional phase) compared to the population from the initial phase (Tlamimilolpa) as well as the population from the final phase (Xolalpan) of the history of Teopancazco. Genetic studies showed no differences in genetic diversity between males and females in the adult population of Teopancazco, this data along with ample archaeological evidence, suggest a neolocal post-marital pattern of residence in Teopancazco. Nevertheless, genetic analyses on the infant population showed that the males are significantly more heterogeneous than the females suggesting a possible differential role in cultural practices by sex in the infant sector. Regarding interpopulation analysis, we found similar indices of genetic diversity between Teopancazco and heterogeneous native groups, which support the multiethnic character of Teopancazco. Finally, our data showed a close genetic relationship between Teopancazco and populations from the

  19. Genetic Evidence Supports the Multiethnic Character of Teopancazco, a Neighborhood Center of Teotihuacan, Mexico (AD 200-600.

    Directory of Open Access Journals (Sweden)

    Brenda A Álvarez-Sandoval

    Full Text Available Multiethnicity in Teopancazco, Teotihuacan, is supported by foreign individuals found in the neighborhood center as well as by the diversity observed in funerary rituals at the site. Studies of both stable and strontium isotopes as well as paleodietary analysis, suggest that the population of Teopancazco was composed by three population groups: people from Teotihuacan, people from nearby sites (Tlaxcala-Hidalgo-Puebla, and people from afar, including the coastal plains. In an attempt to understand the genetic dynamics in Teopancazco we conducted an ancient DNA (aDNA analysis based on mtDNA. Our results show that the level of genetic diversity is consistent with the multiethnicity phenomenon at the neighborhood center. Levels of genetic diversity at different time periods of Teopancazco's history show that multiethnicity was evident since the beginning and lasted until the collapse of the neighborhood center. However, a PCA and a Neighbor-Joining tree suggested the presence of a genetically differentiated group (buried at the Transitional phase compared to the population from the initial phase (Tlamimilolpa as well as the population from the final phase (Xolalpan of the history of Teopancazco. Genetic studies showed no differences in genetic diversity between males and females in the adult population of Teopancazco, this data along with ample archaeological evidence, suggest a neolocal post-marital pattern of residence in Teopancazco. Nevertheless, genetic analyses on the infant population showed that the males are significantly more heterogeneous than the females suggesting a possible differential role in cultural practices by sex in the infant sector. Regarding interpopulation analysis, we found similar indices of genetic diversity between Teopancazco and heterogeneous native groups, which support the multiethnic character of Teopancazco. Finally, our data showed a close genetic relationship between Teopancazco and populations from the

  20. Genetic Evidence Supports the Multiethnic Character of Teopancazco, a Neighborhood Center of Teotihuacan, Mexico (AD 200-600).

    Science.gov (United States)

    Álvarez-Sandoval, Brenda A; Manzanilla, Linda R; González-Ruiz, Mercedes; Malgosa, Assumpció; Montiel, Rafael

    2015-01-01

    Multiethnicity in Teopancazco, Teotihuacan, is supported by foreign individuals found in the neighborhood center as well as by the diversity observed in funerary rituals at the site. Studies of both stable and strontium isotopes as well as paleodietary analysis, suggest that the population of Teopancazco was composed by three population groups: people from Teotihuacan, people from nearby sites (Tlaxcala-Hidalgo-Puebla), and people from afar, including the coastal plains. In an attempt to understand the genetic dynamics in Teopancazco we conducted an ancient DNA (aDNA) analysis based on mtDNA. Our results show that the level of genetic diversity is consistent with the multiethnicity phenomenon at the neighborhood center. Levels of genetic diversity at different time periods of Teopancazco's history show that multiethnicity was evident since the beginning and lasted until the collapse of the neighborhood center. However, a PCA and a Neighbor-Joining tree suggested the presence of a genetically differentiated group (buried at the Transitional phase) compared to the population from the initial phase (Tlamimilolpa) as well as the population from the final phase (Xolalpan) of the history of Teopancazco. Genetic studies showed no differences in genetic diversity between males and females in the adult population of Teopancazco, this data along with ample archaeological evidence, suggest a neolocal post-marital pattern of residence in Teopancazco. Nevertheless, genetic analyses on the infant population showed that the males are significantly more heterogeneous than the females suggesting a possible differential role in cultural practices by sex in the infant sector. Regarding interpopulation analysis, we found similar indices of genetic diversity between Teopancazco and heterogeneous native groups, which support the multiethnic character of Teopancazco. Finally, our data showed a close genetic relationship between Teopancazco and populations from the "Teotihuacan corridor

  1. Evidence to support a food-based dietary guideline on sugar consumption in South Africa

    Directory of Open Access Journals (Sweden)

    Steyn Nelia P

    2012-07-01

    as sugar-sweetened beverages. Conclusion Based on the evidence provided the current DOH food-based dietary guideline on sugar intake should remain as is.

  2. Clonal mutations in primary human glial tumors: evidence in support of the mutator hypothesis

    Directory of Open Access Journals (Sweden)

    Sarkar Chitra

    2007-10-01

    Full Text Available Abstract Background A verifiable consequence of the mutator hypothesis is that even low grade neoplasms would accumulate a large number of mutations that do not influence the tumor phenotype (clonal mutations. In this study, we have attempted to quantify the number of clonal mutations in primary human gliomas of astrocytic cell origin. These alterations were identified in tumor tissue, microscopically confirmed to have over 70% neoplastic cells. Methods Random Amplified Polymorphic DNA (RAPD analysis was performed using a set of fifteen 10-mer primers of arbitrary but definite sequences in 17 WHO grade II astrocytomas (low grade diffuse astrocytoma or DA and 16 WHO grade IV astrocytomas (Glioblastoma Multiforme or GBM. The RAPD profile of the tumor tissue was compared with that of the leucocyte DNA of the same patient and alteration(s scored. A quantitative estimate of the overall genomic changes in these tumors was obtained by 2 different modes of calculation. Results The overall change in the tumors was estimated to be 4.24% in DA and 2.29% in GBM by one method and 11.96% and 6.03% in DA and GBM respectively by the other. The difference between high and lower grade tumors was statistically significant by both methods. Conclusion This study demonstrates the presence of extensive clonal mutations in gliomas, more in lower grade. This is consistent with our earlier work demonstrating that technique like RAPD analysis, unbiased for locus, is able to demonstrate more intra-tumor genetic heterogeneity in lower grade gliomas compared to higher grade. The results support the mutator hypothesis proposed by Loeb.

  3. Can a structured electronic medical record with decision-making support improve nursing home quality? Healthcare administration through structured records

    OpenAIRE

    Krüger, Kjell

    2013-01-01

    Background: Nursing homes face challenges in the coming years due to the increased number of elderly. A new law in force from Jan 2012 (“Samhandlingsreformen”) places more responsibilities on the counties running the nursing homes. Quality will come under pressure, expectations of services will rise and clinical complexity will grow. New strategies are needed to meet this situation. Modern clinical information systems with decision-making support may be part of that. In additio...

  4. Implications of In-Use Photostability: Proposed Guidance for Photostability Testing and Labeling to Support the Administration of Photosensitive Pharmaceutical Products, Part 3. Oral Drug Products.

    Science.gov (United States)

    Allain, Leonardo; Baertschi, Steven W; Clapham, David; Foti, Chris; Lantaff, Wendy M; Reed, Robert A; Templeton, Allen C; Tønnesen, Hanne Hjorth

    2016-05-01

    The ICH Q1B guidance and additional clarifying manuscripts provide the essential information needed to conduct photostability testing for pharmaceutical drug products in the context of manufacturing, packaging, and storage. As the previous 2 papers in this series highlight for drug products administered by injection (part 1) and drug products administered via topical application (part 2), there remains a paucity of guidance and methodological approaches to conducting photostability testing to ensure effective product administration. Part 3 in the series is presented here to provide a similar approach and commentary for photostability testing for oral drug products. The approach taken, as was done previously, is to examine "worst case" photoexposure scenarios in combination with ICH-defined light sources to derive a set of practical experimental approaches to support the safe and effective administration of photosensitive oral drug products. PMID:27056630

  5. A suicide in an online mental health support group: reactions of the group members, administrative responses, and recommendations.

    Science.gov (United States)

    Hsiung, Robert C

    2007-08-01

    Suicides in online mental health support groups are inevitable. This case report of such a suicide describes the responses of the group members and the moderator and makes recommendations. Members of a large, public, mental health message board supported each other, and the moderator, a mental health professional, managed the milieu. A member joined in February 2001 and killed herself in April 2002. The initial response of the members was grief. The moderator attempted to minimize suicide contagion by not making any special announcements and to facilitate mourning by starting a memorial thread. There were no reports of self-injury in response to the suicide, and the online ventilation of grief may in fact have had some preventative effect. One member went to the funeral, and gradually, the group moved on. The moderator later implemented a memorial page. The responses of online groups to suicide may, like those of real-life groups, have resuscitation, rehabilitation, and renewal phases. Diffusion of dependency, a searchable archive, and threaded, asynchronous discussion may facilitate mourning, but anonymity may increase vulnerability to false reports. A thread started in memory of a deceased member may function like a virtual memorial service. A memorial page may function like a virtual cemetery. Preliminary recommendations can be made regarding suicide prevention and responding to suicide in moderated online mental health support groups. PMID:17711356

  6. Medical ethics and screening: on what evidence should we support ourselves?

    Directory of Open Access Journals (Sweden)

    Armando Henrique Norman

    2014-05-01

    neutral, of simple understanding, culturally accessible, so that the users of the health system can better decide about their own health.3From the perspective of public health, distributive ethic justice, and limited healthcare budget - that any health system faces - screening programmes diverts financial resources - which should primarily be allocated to the treatment and care of sick individuals - towards healthy people, with the potential to produce new real patients, due to the damage of the interventions on healthy bodies, generating more costs to the health system and society in general.Fortunately, screening programmes are increasingly losing their strength, especially in Europe. For instance, the Swiss Medical Board10 found no scientific rational for the maintenance of breast screening programmes in light of current available scientific evidence. In Denmark, the rate of mortality attributable to breast cancer have not reduced due to the implementation of systematic breast cancer screening programme with mammography over 17 years follow up,11 however, it has produced an overdiagnosis rate of 33%.12 Similar trends in mortality over the last 30 years were also observed in the United States,13 as well as in Canada, the accumulated 25 years monitoring of the effects of breast cancer screening, did not render reduction in mortality from breast cancer, but resulted in 22% of overdiagnosis.14 Thus, to Peter C. Gotzsche,1 one of the world ‘s leading authorities on the subject, the best method we have to reduce the occurrence of breast cancer is to stop screening with mammography.From an ethical and scientific point of view,10 screening programmes should be discontinued or restricted to high-risk groups or very specific situations, and the focus of prevention should be redirected towards interventions on early-symptomatic patients, since breast cancer treatment has improved considerably in recent decades, and this is likely to be the responsible for improving the quality

  7. Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence.

    Science.gov (United States)

    Sarris, Jerome; McIntyre, Erica; Camfield, David A

    2013-04-01

    Research in the area of herbal psychopharmacology has revealed a variety of promising medicines that may provide benefit in the treatment of general anxiety and specific anxiety disorders. However, a comprehensive review of plant-based anxiolytics has been absent to date. Thus, our aim was to provide a comprehensive narrative review of plant-based medicines that have clinical and/or preclinical evidence of anxiolytic activity. We present the article in two parts. In part one, we reviewed herbal medicines for which only preclinical investigations for anxiolytic activity have been performed. In this current article (part two), we review herbal medicines for which there have been both preclinical and clinical investigations of anxiolytic activity. A search of MEDLINE (PubMed), CINAHL, Scopus and the Cochrane Library databases was conducted (up to 28 October 2012) for English language papers using the search terms 'anxiety' OR 'anxiety disorder' OR 'generalized anxiety disorder' OR 'social phobia' OR 'post-traumatic stress disorder' OR 'panic disorder' OR 'agoraphobia' OR 'obsessive compulsive disorder' in combination with the search terms 'Herb*' OR 'Medicinal Plants' OR 'Botanical Medicine' OR 'Chinese herb*', in addition to individual herbal medicines. This search of the literature revealed 1,525 papers, of which 53 plants were included in the review (having at least one study using the whole plant extract). Of these plants, 21 had human clinical trial evidence (reviewed here in part two), with the other 32 having solely preclinical evidence (reviewed in part one). Support for efficacy was found for chronic use (i.e. greater than one day) of the following herbs in treating a range of anxiety disorders in human clinical trials: Piper methysticum, Matricaria recutita, Ginkgo biloba, Scutellaria lateriflora, Silybum marianum, Passiflora incarnata, Withania somniferum, Galphimia glauca, Centella asiatica, Rhodiola rosea, Echinacea spp., Melissa officinalis and Echium

  8. Pharmacokinetics of Repeated Sodium Salicylate Administration to Laying Hens: Evidence for Time Dependent Increase in Drug Elimination from Plasma and Eggs

    Science.gov (United States)

    Poźniak, Błażej; Grabowski, Tomasz; Motykiewicz-Pers, Karolina; Bobrek, Kamila; Rak, Lech; Bobusia, Katarzyna; Gaweł, Andrzej; Świtała, Marcin

    2015-01-01

    Salicylates were the first non-steroid anti-inflammatory drugs (NSAIDs) to be used in any species and are still widely used in humans and livestock. However, the data on their pharmacokinetics in animals is limited, especially after repeated administration. Evidence exist that in chickens (Gallus gallus) salicylate (SA) may induce its own elimination. The aim of this study was to investigate salicylate pharmacokinetics and egg residues during repeated administration of sodium salicylate (SS) to laying hens. Pharmacokinetics of SA was assessed during 14 d oral administration of SS at daily doses of 50 mg/kg and 200 mg/kg body weight to laying hens. On the 1st, 7th and 14th d a 24 h-long pharmacokinetic study was carried out, whereas eggs were collected daily. Salicylate concentrations in plasma and eggs were determined using high-performance liquid chromatography with ultraviolet detection and pharmacokinetic variables were calculated using a non-compartmental model. Mean residence time (MRT), minimal plasma concentration (Cmin, C16h) and elimination half-life (T1/2el) of SA showed gradual decrease in layers administered with a lower dose. Total body clearance (ClB) increased. Layers administered with the higher dose showed a decrease only in the T1/2el. In the low dose group, SA was found only in the egg white and was low throughout the experiment. Egg whites from the higher dose group showed initially high SA levels which significantly decreased during the experiment. Yolk SA levels were lower and showed longer periods of accumulation and elimination. Repeated administration of SS induces SA elimination, although this effect may differ depending on the dose and production type of a chicken. Decreased plasma drug concentration may have clinical implications during prolonged SS treatment. PMID:25893240

  9. Pharmacokinetics of repeated sodium salicylate administration to laying hens: evidence for time dependent increase in drug elimination from plasma and eggs.

    Directory of Open Access Journals (Sweden)

    Błażej Poźniak

    Full Text Available Salicylates were the first non-steroid anti-inflammatory drugs (NSAIDs to be used in any species and are still widely used in humans and livestock. However, the data on their pharmacokinetics in animals is limited, especially after repeated administration. Evidence exist that in chickens (Gallus gallus salicylate (SA may induce its own elimination. The aim of this study was to investigate salicylate pharmacokinetics and egg residues during repeated administration of sodium salicylate (SS to laying hens. Pharmacokinetics of SA was assessed during 14 d oral administration of SS at daily doses of 50 mg/kg and 200 mg/kg body weight to laying hens. On the 1st, 7th and 14th d a 24 h-long pharmacokinetic study was carried out, whereas eggs were collected daily. Salicylate concentrations in plasma and eggs were determined using high-performance liquid chromatography with ultraviolet detection and pharmacokinetic variables were calculated using a non-compartmental model. Mean residence time (MRT, minimal plasma concentration (Cmin, C16h and elimination half-life (T1/2el of SA showed gradual decrease in layers administered with a lower dose. Total body clearance (ClB increased. Layers administered with the higher dose showed a decrease only in the T1/2el. In the low dose group, SA was found only in the egg white and was low throughout the experiment. Egg whites from the higher dose group showed initially high SA levels which significantly decreased during the experiment. Yolk SA levels were lower and showed longer periods of accumulation and elimination. Repeated administration of SS induces SA elimination, although this effect may differ depending on the dose and production type of a chicken. Decreased plasma drug concentration may have clinical implications during prolonged SS treatment.

  10. Consistent evidence to support the use of xylitol- and sorbitol-containing chewing gum to prevent dental caries

    DEFF Research Database (Denmark)

    Twetman, Svante

    2009-01-01

    DATA SOURCES: Studies were identified using searches with Medline, the Cochrane Library and Google Scholar. STUDY SELECTION: Studies were screened independently and were included if they evaluated the effect of one or more chewing gums containing at least one polyol (xylitol, sorbitol, mannitol or...... [six randomised controlled trials (RCT) of which four were cluster RCT, nine controlled clinical trials (CCT) and four cohort studies]. Two RCT had a Jadad score of three or higher. The mean preventive fraction for the four main gum types are shown in the table 1, results of all except the sorbitol...... -mannitol blend were statistically significant. Sensitivity analyses confirmed the robustness of the findings. CONCLUSIONS: Although research gaps exist, particularly on optimal dosing and relative polyol efficacy, there is consistent evidence to support the use of xylitol- and sorbitol-containing chewing...

  11. Mental Health Clinicians' Participation in Web-Based Training for an Evidence Supported Intervention: Signs of Encouragement and Trouble Ahead.

    Science.gov (United States)

    McMillen, J Curtis; Hawley, Kristin M; Proctor, Enola K

    2016-07-01

    Comprehensive scalable clinician training is needed to increase the impact of evidence-supported psychotherapies. This study was designed to ascertain clinician participation in different low-cost training activities, what predicts their training participation, and how participation can be increased. The study enrolled 163 clinicians. Of these, 105 completed a follow-up survey and 20 completed a more in-depth qualitative interview. Some activities (web training) attracted greater participation than others (e.g., discussion boards, role playing). Key findings include the desirability of self-paced learning and the flexibility it afforded practicing clinicians. However, some found the lack of accountability insurmountable. Many desired in-person training as a way to introduce accountability and motivation. While low-cost, relevant, self-paced learning appeals to practicing clinicians, it may need to be combined with opportunities for in-person training and accountability mechanisms in order to encourage large numbers of clinicians to complete training. PMID:25822326

  12. Affected-sib-pair analyses reveal support of prior evidence for a susceptibility locus for bipolar disorder, on 21q

    Energy Technology Data Exchange (ETDEWEB)

    Detera-Wadleigh, S.D.; Badner, J.A.; Goldin, L.R. [National Inst. of Health, Bethesda, MD (United States)] [and others

    1996-06-01

    In 22 multiplex pedigrees screened for linkage to bipolar disorder, by use of 18 markers on chromosome 21q, single-locus affected-sib-pair (ASP) analysis detected a high proportion (57%-62%) of alleles shared identical by descent (IBD), with P values of .049-.0008 on nine marker loci. Multilocus ASP analyses revealed locus trios in the distal region between D21S270 and D21S171, with excess allele sharing (nominal P values <.01) under two affection-status models, ASM I (bipolars and schizoaffectives) and ASM II (ASM I plus recurrent unipolars). In addition, under ASM I, the proximal interval spanned by D21S1436 and D21S65 showed locus trios with excess allele sharing (nominal P values of .03-.0003). These findings support prior evidence that a susceptibility locus for bipolar disorder is on 21q. 38 refs., 4 tabs.

  13. SUPPORT Tools for evidence-informed health Policymaking (STP 9: Assessing the applicability of the findings of a systematic review

    Directory of Open Access Journals (Sweden)

    Fretheim Atle

    2009-12-01

    Full Text Available Abstract This article is part of a series written for people responsible for making decisions about health policies and programmes and for those who support these decision makers. Differences between health systems may often result in a policy or programme option that is used in one setting not being feasible or acceptable in another. Or these differences may result in an option not working in the same way in another setting, or even achieving different impacts in another setting. A key challenge that policymakers and those supporting them must face is therefore the need to understand whether research evidence about an option can be applied to their setting. Systematic reviews make this task easier by summarising the evidence from studies conducted in a variety of different settings. Many systematic reviews, however, do not provide adequate descriptions of the features of the actual settings in which the original studies were conducted. In this article, we suggest questions to guide those assessing the applicability of the findings of a systematic review to a specific setting. These are: 1. Were the studies included in a systematic review conducted in the same setting or were the findings consistent across settings or time periods? 2. Are there important differences in on-the-ground realities and constraints that might substantially alter the feasibility and acceptability of an option? 3. Are there important differences in health system arrangements that may mean an option could not work in the same way? 4. Are there important differences in the baseline conditions that might yield different absolute effects even if the relative effectiveness was the same? 5. What insights can be drawn about options, implementation, and monitoring and evaluation? Even if there are reasonable grounds for concluding that the impacts of an option might differ in a specific setting, insights can almost always be drawn from a systematic review about possible options

  14. Restoring State Control Over Forest Resources Through Administrative Procedures: Evidence From a Community Forestry Programme in Central Java, Indonesia

    Directory of Open Access Journals (Sweden)

    Ahmad Maryudi

    2012-01-01

    Full Text Available In recent years, community forestry has emerged as a means to reform power constellations with regard to forest governance. Through community forestry, the central state promised to devolve several forest rights to local communities and encouraged them to get involved in decision making processes and the implementation of forest activities. However, experience in some countries indicates that the implementation of community forestry programmes is rarely followed by genuine power devolution to local forest users. Instead, these programmes may even serve as a means to retain or restore the central state’s control over forests. Using a case study of a community forestry programme implemented in Java, Indonesia, by a state forest company, this paper argues that the implementation of community forestry is also driven by the state’s interests to regain control over the forests. Research in eight villages in Central Java province reveals that the community forestry programmes are carefully structured according to numerous administrative procedures and estab- lish a mode of control through a bureaucratic design. ----- In den letzten Jahren hat sich community forestry als Mittel zur Reform von Machtkonstellationen in Bezug auf die Verwaltung von Wäldern herausgebildet. Der Zentralstaat versprach durch community forestry bestimmte Waldrechte an lokale Communities abzugeben und ermutigte sie, sich an Entscheidungsprozessen und der Implementierung von Forstaktivitäten zu beteiligen. Erfahrungen in einigen Ländern zeigen jedoch, dass die Implementierung von community forestry-Programmen selten mit einem tatsächlichen Machttransfer an lokale ForstnutzerInnen einhergeht, sondern diese Programme sogar als Mittel zur Rückgewinnung von zentralstaatlicher Kontrolle über Wälder dienen können. Anhand eines Fallbeispiels eines community forestry-Programms, das in Java, Indonesien, von einem staatlichen Forstunternehmen implementiert wird, argumentiere ich

  15. Review of the scientific evidence to support environmental risk assessment of shale gas development in the UK.

    Science.gov (United States)

    Prpich, George; Coulon, Frédéric; Anthony, Edward J

    2016-09-01

    Interest in the development of shale gas resources using hydraulic fracturing techniques is increasing worldwide despite concerns about the environmental risks associated with this activity. In the United Kingdom (UK), early attempts to hydraulically fracture a shale gas well resulted in a seismic event that led to the suspension of all hydraulic fracturing operations. In response to this occurrence, UK regulators have requested that future shale gas operations that use hydraulic fracturing should be accompanied by a high-level environmental risk assessment (ERA). Completion of an ERA can demonstrate competency, communicate understanding, and ultimately build trust that environmental risks are being managed properly, however, this assessment requires a scientific evidence base. In this paper we discuss how the ERA became a preferred assessment technique to understand the risks related to shale gas development in the UK, and how it can be used to communicate information between stakeholders. We also provide a review of the evidence base that describes the environmental risks related to shale gas operations, which could be used to support an ERA. Finally, we conclude with an update of the current environmental risks associated with shale gas development in the UK and present recommendations for further research. PMID:26627123

  16. Acceptance of evidence-supported hypotheses generates a stronger signal from an underlying functionally-connected network.

    Science.gov (United States)

    Whitman, J C; Takane, Y; Cheung, T P L; Moiseev, A; Ribary, U; Ward, L M; Woodward, T S

    2016-02-15

    Choosing one's preferred hypothesis requires multiple brain regions to work in concert as a functionally connected network. We predicted that a stronger network signal would underlie cognitive coherence between a hypothesis and the available evidence. In order to identify such functionally connected networks in magnetoencephalography (MEG) data, we first localized the generators of changes in oscillatory power within three frequency bands, namely alpha (7-13Hz), beta (18-24Hz), and theta (3-7Hz), with a spatial resolution of 5mm and temporal resolution of 50ms. We then used principal component analysis (PCA) to identify functionally connected networks reflecting co-varying post-stimulus changes in power. As predicted, PCA revealed a functionally connected network with a stronger signal when the evidence supported accepting the hypothesis being judged. This difference was driven by beta-band power decreases in the left dorsolateral prefrontal cortex (DLPFC), ventromedial prefrontal cortex (VMPFC), posterior cingulate cortex (PCC), and midline occipital cortex. PMID:26702776

  17. The Affordances of Using a Teacher Leadership Network to Support Leadership Development: Creating Collaborative Thinking Spaces to Strengthen Teachers' Skills in Facilitating Productive Evidence-Informed Conversations

    Science.gov (United States)

    Nicholson, Julie; Capitelli, Sarah; Richert, Anna E.; Bauer, Anne; Bonetti, Sara

    2016-01-01

    School reform policies and school administrators are increasingly positioning teacher leaders (TLs) with the responsibility to facilitate professional learning for their colleagues. Although ample evidence exists to suggest the need for facilitators to be highly skilled for teachers' learning to be optimized, there is a dearth of research…

  18. System administrator's manual (SAM) for the enhanced logistics intratheater support tool (ELIST) database segment version 8.1.0.0 for solaris 7.; TOPICAL

    International Nuclear Information System (INIS)

    This document is the System Administrator's Manual (SAM) for the Enhanced Logistics Intratheater Support Tool (ELIST) Database Segment. It covers errors that can arise during the segment's installation and deinstallation, and it outlines appropriate recovery actions. It also tells how to extend the database storage available to Oracle if a datastore becomes filled during the use of ELIST. The latter subject builds on some of the actions that must be performed when installing this segment, as documented in the Installation Procedures (IP) for the Enhanced Logistics Intratheater Support Tool (ELIST) Global Data Segment, Database Instance Segment, Database Fill Segment, Database Segment, Database Utility Segment, Software Segment, and Reference Data Segment (referred to in portions of this document as the ELIST IP). The information in this document is expected to be of use only rarely. Other than errors arising from the failure to follow instructions, difficulties are not expected to be encountered during the installation or deinstallation of the segment. The need to extend database storage likewise typically arises infrequently. Most administrators will only need to be aware of the help that is provided in this document and will probably not actually need to read and make use of it

  19. System administrator's manual (SAM) for the enhanced logistics intratheater support tool (ELIST) database instance segment version 8.1.0.0 for solaris 7.; TOPICAL

    International Nuclear Information System (INIS)

    This document is the System Administrator's Manual (SAM) for the Enhanced Logistics Intratheater Support Tool (ELIST) Database Instance Segment. It covers errors that can arise during the segment's installation and deinstallation, and it outlines appropriate recovery actions. It also tells how to change the password for the SYSTEM account of the database instance after the instance is created, and it discusses the creation of a suitable database instance for ELIST by means other than the installation of the segment. The latter subject is covered in more depth than its introductory discussion in the Installation Procedures (IP) for the Enhanced Logistics Intratheater Support Tool (ELIST) Global Data Segment, Database Instance Segment, Database Fill Segment, Database Segment, Database Utility Segment, Software Segment, and Reference Data Segment (referred to in portions of this document as the ELIST IP). The information in this document is expected to be of use only rarely. Other than errors arising from the failure to follow instructions, difficulties are not expected to be encountered during the installation or deinstallation of the segment. By the same token, the need to create a database instance for ELIST by means other than the installation of the segment is expected to be the exception, rather than the rule. Most administrators will only need to be aware of the help that is provided in this document and will probably not actually need to read and make use of it

  20. Gateway Effects: Why the Cited Evidence Does Not Support Their Existence for Low-Risk Tobacco Products (and What Evidence Would

    Directory of Open Access Journals (Sweden)

    Carl V. Phillips

    2015-05-01

    Full Text Available It is often claimed that low-risk drugs still create harm because of “gateway effects”, in which they cause the use of a high-risk alternative. Such claims are popular among opponents of tobacco harm reduction, claiming that low-risk tobacco products (e.g., e-cigarettes, smokeless tobacco cause people to start smoking, sometimes backed by empirical studies that ostensibly support the claim. However, these studies consistently ignore the obvious alternative causal pathways, particularly that observed associations might represent causation in the opposite direction (smoking causes people to seek low-risk alternatives or confounding (the same individual characteristics increase the chance of using any tobacco product. Due to these complications, any useful analysis must deal with simultaneity and confounding by common cause. In practice, existing analyses seem almost as if they were designed to provide teaching examples about drawing simplistic and unsupported causal conclusions from observed associations. The present analysis examines what evidence and research strategies would be needed to empirically detect such a gateway effect, if there were one, explaining key methodological concepts including causation and confounding, examining the logic of the claim, identifying potentially useful data, and debunking common fallacies on both sides of the argument, as well as presenting an extended example of proper empirical testing. The analysis demonstrates that none of the empirical studies to date that are purported to show a gateway effect from tobacco harm reduction products actually does so. The observations and approaches can be generalized to other cases where observed association of individual characteristics in cross-sectional data could result from any of several causal relationships.

  1. Economic Growth and Expansion of China’s Urban Land Area: Evidence from Administrative Data and Night Lights, 1993–2012

    Directory of Open Access Journals (Sweden)

    John Gibson

    2014-11-01

    Full Text Available The relationship between economic growth, expansion of urban land area and the broader issue of cultivated land conversion in China has been closely examined for the late 1980s and 1990s. Much less is known about recent urban expansion and if the effects of economic growth on this expansion have changed over time. This paper updates estimates of urban expansion for China and examines the relationship with city economic growth for 1993–2012. To see if patterns are robust to different types of evidence, administrative data on the area of 225 urban cores are compared to estimates of brightly lit areas from remotely sensed night lights. The trend annual expansion rate in lit area is 8% and was significantly faster in the decade to 2002 than in the most recent decade. Expansion is slower according to administrative data, at just 5% per annum, with no change in unconditional expansion rates between decades, while conditional expansion rates have declined. The elasticity of area with respect to city economic output is about 0.3. Over time, expansion of urban land area is becoming less responsive to the growth of the local non-agricultural population.

  2. Further Research is Required to Determine Which Database Products Best Support Research in Public Administration. A review of: Tucker, James, Corey. “Database Support for Research in Public Administration.” Behavioral & Social Sciences Librarian 24.1 (2005): 47-60.

    OpenAIRE

    David Hook

    2006-01-01

    Objective – To examine the extent to which six commercial database products support student and faculty research in the area of public administration. Design – Bibliometric study. Setting – Academic library in the United States. Subjects – Six commercial business‐related database products were examined: Proquest’s ABI/INFORM Global edition (ABI), EBSCO’s Business Source Premier (BSP), Gale’s General BusinessFile ASAP (GBF), EBSCO’s Academic Search Premier (ASP), EBSCO’s Expanded ...

  3. 44 CFR 295.41 - Administrative appeal.

    Science.gov (United States)

    2010-10-01

    ... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Administrative appeal. 295.41 Section 295.41 Emergency Management and Assistance FEDERAL EMERGENCY MANAGEMENT AGENCY, DEPARTMENT OF... supplement the statement of reasons and provide any additional documentary evidence supporting the...

  4. On Criminal Judicialization of the Administrative Evidence%行政证据刑事司法化--兼论《刑事诉讼法》第52条的理解与适用

    Institute of Scientific and Technical Information of China (English)

    张慧

    2014-01-01

    The 2012 criminal procedure law determines that the administrative evidence can be used as evidence in criminal lawsuit, negating the traditional evidence conversion in theory. The criminal judicialization of the administrative evidence arose. To the evidence conversion, the criminal judicialization of the administrative evidence is more consistent with the legislative intention, manifests the systematization of criminal law, respects and guarantees human rights and the value of lawsuit efficiency and plays a guiding role to improve the lawmaking. The effective connection of the administrative evidence and the criminal evidence cannot separate the judiciary and the justice, that’s to say, we must understand well the importance of the administrative evidence in the process of the criminal judicial procedure and its key role, build up ideas to respect and safeguard human rights.%2012《刑事诉讼法》对行政证据在刑事诉讼中作为证据使用予以认可,从理论维度对传统的证据转换说予以否定,行政证据刑事司法化应运而生。较证据转换说而言,行政证据刑事司法化更符合立法原意,体现刑事法律的体系化,遵循尊重和保障人权以及诉讼效率的价值,对立法完善起着导向作用。有效衔接行政证据与刑事证据,离不开司法人员合法、正当司法:明确行政证据在刑事司法程序中的重要性以及所扮演的关键角色,树立尊重和保障人权的理念。

  5. Do community pharmacists have the attitudes and knowledge to support evidence based self-management of low back pain?

    Directory of Open Access Journals (Sweden)

    Waddell Gordon

    2007-01-01

    Full Text Available Abstract Background In many countries, community pharmacists can be consulted without appointment in a large number of convenient locations. They are in an ideal position to give advice to patients at the onset of low back pain and also reinforce advice given by other healthcare professionals. There is little specific information about the quality of care provided in the pharmacy for people with back pain. The main objectives of this survey were to determine the attitudes, knowledge and reported practice of English pharmacists advising people who present with acute or chronic low back pain. Methods A questionnaire was designed for anonymous self-completion by pharmacists attending continuing education sessions. Demographic questions were designed to allow comparison with a national pharmacy workforce survey. Attitudes were measured with the Back Beliefs Questionnaire (BBQ and questions based on the Working Backs Scotland campaign. Questions about the treatment of back pain in the community pharmacy were written (or adapted to reflect and characterise the nature of practice. In response to two clinical vignettes, respondents were asked to select proposals that they would recommend in practice. Results 335 responses from community pharmacists were analysed. Middle aged pharmacists, women, pharmacy managers and locums were over-represented compared to registration and workforce data. The mean (SD BBQ score for the pharmacists was 31.37 (5.75, which was slightly more positive than in similar surveys of other groups. Those who had suffered from back pain seem to demonstrate more confidence (fewer negative feelings, more advice opportunities and better advice provision in their perception of advice given in the pharmacy. Awareness of written information that could help to support practice was low. Reponses to the clinical vignettes were generally in line with the evidence base. Pharmacists expressed some caution about recommending activity. Most

  6. Can Scientific Evidence Support Using Bangladeshi Traditional Medicinal Plants in the Treatment of Diarrhoea? A Review on Seven Plants

    Directory of Open Access Journals (Sweden)

    Karl E. Malterud

    2013-05-01

    Full Text Available Diarrhoea is a common disease which causes pain and may be deadly, especially in developing countries. In Bangladesh, diarrhoeal diseases affect thousands of people every year, and children are especially vulnerable. Bacterial toxins or viral infections are the most common cause of the disease. The diarrhoea outbreaks are often associated with flood affected areas with contaminated drinking water and an increased risk of spreading the water-borne disease. Not surprisingly, plants found in the near surroundings have been taken into use by the local community as medicine to treat diarrhoeal symptoms. These plants are cheaper and more easily available than conventional medicine. Our question is: What is the level of documentation supporting the use of these plants against diarrhoea and is their consumption safe? Do any of these plants have potential for further exploration? In this review, we have choosen seven plant species that are used in the treatment of diarrhoea; Diospyros peregrina, Heritiera littoralis, Ixora coccinea, Pongamia pinnata, Rhizophora mucronata, Xylocarpus granatum, and Xylocarpus moluccensis. Appearance and geographical distribution, traditional uses, chemical composition, and biological studies related to antidiarrhoeal activity will be presented. This review reveals that there is limited scientific evidence supporting the traditional use of these plants. Most promising are the barks from D. peregrina, X. granatum and X. moluccensis which contain tannins and have shown promising results in antidiarrhoeal mice models. The leaves of P. pinnata also show potential. We suggest these plants should be exploited further as possible traditional herbal remedies against diarrhoea including studies on efficacy, optimal dosage and safety.

  7. Monitoring and supervision of the Support Centre for Family Health (NASF in an administrative region of the Distrito Federal using analysis of interviews

    Directory of Open Access Journals (Sweden)

    Michelline Ribeiro Rodriguez

    2014-01-01

    Full Text Available Objective: To analyze the monitoring and supervision of the actions of the Support Centre for Family Health (NASF in an administrative region of Distrito Federal (DF, Riacho Fundo II. Methods: Semi-structured interviews were conducted with five NASF managers who were responsible for its management at the Regional, District, and Federal levels. These interviews were recorded, transcribed, and analyzed according to Bardin’s Content Analysis Method. Results: There is no registration system that includes all actions performed by NASF. Also, there is lack of uniformity in the supervision pattern used by the responsible bodies, due to inefficient flow of information regarding the work of this centre throughout the three hierarchical levels. Conclusion: The recent implementation of NASF in Distrito Federal was considered the major factor behind the poor quality of production registers and the absence of evaluative indicators of NASF activities.

  8. Line-depth-ratio temperatures for the close binary nu Octantis: new evidence supporting the conjectured retrograde planet

    CERN Document Server

    Ramm, David J

    2016-01-01

    We explore the possibly that either star-spots or pulsations are the cause of a periodic radial-velocity signal (P~400 days) from the K-giant binary nu Octantis (P~1050 days, e~0.25), alternatively conjectured to have a retrograde planet. Our study is based on temperatures derived from 22 line-depth ratios (LDRs) for nu Oct and twenty calibration stars. Empirical evidence and stability modelling provide unexpected support for the planet since other standard explanations (star-spots, pulsations and additional stellar masses) each have credibility problems. However, the proposed system presents formidable challenges to planet-formation and stability theories: it has by far the smallest stellar separation of any claimed planet-harbouring binary (a_bin~2.6 au) and an equally unbelievable separation ratio (a_pl/a_bin~0.5), hence the necessity that the circumstellar orbit be retrograde. The LDR analysis of 215 nu Oct spectra acquired between 2001--2007, from which the RV perturbation was first revealed, have no sig...

  9. The Weight of Evidence Does Not Support the Listing of Styrene as “Reasonably Anticipated to be a Human Carcinogen” in NTP's Twelfth Report on Carcinogens

    OpenAIRE

    Rhomberg, Lorenz R.; Goodman, Julie E.; Prueitt, Robyn L.

    2013-01-01

    Styrene was listed as “reasonably anticipated to be a human carcinogen” in the twelfth edition of the National Toxicology Program's Report on Carcinogens based on what we contend are erroneous findings of limited evidence of carcinogenicity in humans, sufficient evidence of carcinogenicity in experimental animals, and supporting mechanistic data. The epidemiology studies show no consistent increased incidence of, or mortality from, any type of cancer. In animal studies, increased incidence ra...

  10. Evaluation of Organizational Readiness in Clinical Settings for Social Supporting Evidence-Based Information Seeking Behavior after Introducing IT in a Developing Country.

    Science.gov (United States)

    Kahouei, Mehdi; Alaei, Safollah; Panahi, Sohaila Sadat Ghazavi Shariat; Zadeh, Jamileh Mahdi

    2015-01-01

    The health sector of Iran has endeavored to encourage physicians and medical students to use research findings in their practice. Remarkable changes have occurred, including: holding computer skills courses, digital library workshops for physicians and students, and establishing websites in hospitals. The findings showed that a small number of the participants completely agreed that they were supported by supervisors and colleagues to use evidence-based information resources in their clinical decisions. Health care organizations in Iran need other organizational facilitators such as social influences, organizational support, leadership, strong organizational culture, and climate in order to implement evidence-based practice. PMID:25839913

  11. Evidence-Based Support for the Characteristics of Tsunami Warning Messages for Local, Regional and Distant Sources

    Science.gov (United States)

    Gregg, C. E.; Johnston, D. M.; Sorensen, J. H.; Vogt Sorensen, B.; Whitmore, P.

    2014-12-01

    Many studies since 2004 have documented the dissemination and receipt of risk information for local to distant tsunamis and factors influencing people's responses. A few earlier tsunami studies and numerous studies of other hazards provide additional support for developing effective tsunami messages. This study explores evidence-based approaches to developing such messages for the Pacific and National Tsunami Warning Centers in the US. It extends a message metric developed for the NWS Tsunami Program. People at risk to tsunamis receive information from multiple sources through multiple channels. Sources are official and informal and environmental and social cues. Traditionally, official tsunami messages followed a linear dissemination path through relatively few channels from warning center to emergency management to public and media. However, the digital age has brought about a fundamental change in the dissemination and receipt of official and informal communications. Information is now disseminated in very non-linear paths and all end-user groups may receive the same message simultaneously. Research has demonstrated a range of factors that influence rapid respond to an initial real or perceived threat. Immediate response is less common than one involving delayed protective actions where people first engage in "milling behavior" to exchange information and confirm the warning before taking protective action. The most important message factors to achieve rapid response focus on the content and style of the message and the frequency of dissemination. Previously we developed a tsunami message metric consisting of 21 factors divided into message content and style and receiver characteristics. Initially, each factor was equally weighted to identify gaps, but here we extend the work by weighting specific factors. This utilizes recent research that identifies the most important determinants of protective action. We then discuss the prioritization of message information

  12. In vitro evidence supports the presence of glucokinase-independent glucosensing mechanisms in hypothalamus and hindbrain of rainbow trout.

    Science.gov (United States)

    Otero-Rodiño, Cristina; Velasco, Cristina; Álvarez-Otero, Rosa; López-Patiño, Marcos A; Míguez, Jesús M; Soengas, José L

    2016-06-01

    We previously obtained evidence in rainbow trout for the presence and response to changes in circulating levels of glucose (induced by intraperitoneal hypoglycaemic and hyperglycaemic treatments) of glucosensing mechanisms based on liver X receptor (LXR), mitochondrial production of reactive oxygen species (ROS) leading to increased expression of uncoupling protein 2 (UCP2), and sweet taste receptor in the hypothalamus, and on sodium/glucose co-transporter 1 (SGLT-1) in hindbrain. However, these effects of glucose might be indirect. Therefore, we evaluated the response of parameters related to these glucosensing mechanisms in a first experiment using pooled sections of hypothalamus and hindbrain incubated for 6 h at 15°C in modified Hanks' medium containing 2, 4 or 8 mmol l(-1) d-glucose. The responses observed in some cases were consistent with glucosensing capacity. In a second experiment, pooled sections of hypothalamus and hindbrain were incubated for 6 h at 15°C in modified Hanks' medium with 8 mmol l(-1) d-glucose alone (control) or containing 1 mmol l(-1) phloridzin (SGLT-1 antagonist), 20 µmol l(-1) genipin (UCP2 inhibitor), 1 µmol l(-1) trolox (ROS scavenger), 100 µmol l(-1) bezafibrate (T1R3 inhibitor) and 50 µmol l(-1) geranyl-geranyl pyrophosphate (LXR inhibitor). The response observed in the presence of these specific inhibitors/antagonists further supports the proposal that critical components of the different glucosensing mechanisms are functioning in rainbow trout hypothalamus and hindbrain. PMID:27026717

  13. Further Research is Required to Determine Which Database Products Best Support Research in Public Administration. A review of: Tucker, James, Corey. “Database Support for Research in Public Administration.” Behavioral & Social Sciences Librarian 24.1 (2005: 47-60.

    Directory of Open Access Journals (Sweden)

    David Hook

    2006-06-01

    Full Text Available Objective – To examine the extent to which six commercial database products support student and faculty research in the area of public administration. Design – Bibliometric study. Setting – Academic library in the United States. Subjects – Six commercial business‐related database products were examined: Proquest’s ABI/INFORM Global edition (ABI, EBSCO’s Business Source Premier (BSP, Gale’s General BusinessFile ASAP (GBF, EBSCO’s Academic Search Premier (ASP, EBSCO’s Expanded Academic Index (EAI and Proquest’s International Academic Research Library (ARL. Three of the databases (ABI, BSP, GBF were chosen because they address the management, human resource, and financing elements of public administration. The other three (ASP, EAI, ARL were included because of their multidisciplinary coverage. Methods – A list of journal titles covering public administration was assembled from the Institute of Scientific Information’s Social Sciences Citation Index and previously published lists of recommended journals in the field. The author then compared the compiled list of journal titles against the journal titles indexed by the six database products. He further analyzed the results by level of journal coverage (abstract only, full‐text, and full‐text with embargo and subject area based on categories described in Ulrich’s Periodicals Directory. Main Results – The study found that three of the six database products ‐‐EAI, BSP, and ARL ‐‐ provide indexing for the greatest number of public administration journals contained in the compiled list. EIA and ARL cover the greatest number of those that are full‐text journals, while BSP and ASP cover the greatest number of those full‐text journals limited by publisher embargoes. Conclusion – The author concludes that of the six databases examined, EAI, BSP, and ARL are the best for public administration research, based on their strength in the subject areas of public

  14. Thematic Issue Symposium: What Criteria Should be Used to Judge the Admissibility of Evidence to Support Theoretical Propositions Regarding Communication Research?

    Science.gov (United States)

    Fisher, Walter R., Ed.

    1978-01-01

    In response to an earlier symposium report, this journal presents six position papers dealing with the question, "What criteria should be used to judge the admissibility of evidence to support theoretical propositions regarding communication research?" The analyses and arguments include "The Research Process" by Wayne Brockriede, "The Reflexivity…

  15. Thematic Issue--Symposium: What Criteria Should Be Used to Judge the Admissibility of Evidence to Support Theoretical Propositions Regarding Communication Research?

    Science.gov (United States)

    Fisher, Walter R., Ed.

    1977-01-01

    This journal details the results of a symposium created to address the question, "What criteria should be used to judge the admissibility of evidence to support theoretical propositions regarding communication research?" Moderators Gary Cronkhite and Jo Liska provide both an introduction and a summary of the three position papers that form the…

  16. Electronic Clinic Journaling: The Use of Weblogs to Support Evidence-Based Practice in Doctor of Audiology Students

    Science.gov (United States)

    Neldon, Gayle B.

    2009-01-01

    Evidence-based practice (EBP) is a strategy for the provision of high quality health care. The use of journals to document clinical experiences and reflection has been used in speech-language pathology as well as nursing and psychology. This study uses qualitative analysis to study what AuD students learn about evidence-based practice from writing…

  17. Social Support and Supervisory Quality Interventions in the Workplace: A Stakeholder-Centered Best-Evidence Synthesis of Systematic Reviews on Work Outcomes

    Directory of Open Access Journals (Sweden)

    SL Wagner

    2015-10-01

    Full Text Available Background: There is controversy surrounding the impact of workplace interventions aimed at improving social support and supervisory quality on absenteeism, productivity and financial outcomes.Objective: To determine the value of social support interventions for work outcomes.Methods: Databases were searched for systematic reviews between 2000 and 2012 to complete a synthesis of systematic reviews guided by the PRISMA statement and the IOM guidelines for systematic reviews. Assessment of articles for inclusion and methodological quality was conducted independently by at least two researchers, with differences resolved by consensus.Results: The search resulted in 3363 titles of which 3248 were excluded following title/abstract review, leaving 115 articles that were retrieved and underwent full article review. 10 articles met the set inclusion criteria, with 7 focusing on social support, 2 on supervisory quality and 1 on both. We found moderate and limited evidence, respectively, that social support and supervisory quality interventions positively impact workplace outcomes.Conclusion: There is moderate evidence that social support and limited evidence that supervisory quality interventions have a positive effect on work outcomes.

  18. Neonatal non-invasive respiratory support: synchronised NIPPV, non-synchronised NIPPV or bi-level CPAP: what is the evidence in 2013?

    Science.gov (United States)

    Roberts, C T; Davis, P G; Owen, L S

    2013-01-01

    Nasal continuous positive airway pressure (NCPAP) has proven to be an effective mode of non-invasive respiratory support in preterm infants; however, many infants still require endotracheal ventilation, placing them at an increased risk of morbidities such as bronchopulmonary dysplasia. Several other modes of non-invasive respiratory support beyond NCPAP, including synchronised and non-synchronised nasal intermittent positive pressure ventilation (SNIPPV and nsNIPPV) and bi-level positive airway pressure (BiPAP) are now also available. These techniques require different approaches, and the exact mechanisms by which they act remain unclear. SNIPPV has been shown to reduce the rate of reintubation in comparison to NCPAP when used as post-extubation support, but the evidence for nsNIPPV and BiPAP in this context is less convincing. There is some evidence that NIPPV (whether synchronised or non-synchronised) used as primary respiratory support is beneficial, but the variation in study methodology makes this hard to translate confidently into clinical practice. There is currently no evidence to suggest a reduction in mortality or important morbidities such as bronchopulmonary dysplasia, with NIPPV or BiPAP in comparison to NCPAP, and there is a lack of appropriately designed studies in this area. This review discusses the different approaches and proposed mechanisms of action of SNIPPV, nsNIPPV and BiPAP, the challenges of applying the available evidence for these distinct modalities of non-invasive respiratory support to clinical practice, and possible areas of future research. PMID:23989138

  19. Understanding land administration systems

    OpenAIRE

    P. Williamson, Ian; Enemark, Stig; Wallace, Judy; Rajabifard, Abbas

    2008-01-01

    This paper introduces basic land administration theory and highlights four key concepts that are fundamental to understanding modern land administration systems - firstly the land management paradigm and its influence on the land administration framework, secondly the role that the cadastre plays in contributing to sustainable development, thirdly the changing nature of ownership and the role of land markets, and lastly a land management vision that promotes land administration in support of ...

  20. Regulators as agents: Modelling personality and power as evidence is brokered to support decisions on environmental risk

    Energy Technology Data Exchange (ETDEWEB)

    Davies, G.J. [Cranfield University, Centre for Environmental Risks and Futures, School of Applied Sciences, Cranfield MK43 0AL (United Kingdom); Kendall, G. [University of Nottingham, School of Computer Science, Nottingham NG8 1BB (United Kingdom); University of Nottingham Malaysia Campus, Jalan Broga, 43500 Semenyih, Selangor Darul Ehsan (Malaysia); Soane, E. [London School of Economics and Political Science, Department of Management, London WC2A 2AE (United Kingdom); Li, J. [University of Nottingham, School of Computer Science, Nottingham NG8 1BB (United Kingdom); Rocks, S.A.; Jude, S.R. [Cranfield University, Centre for Environmental Risks and Futures, School of Applied Sciences, Cranfield MK43 0AL (United Kingdom); Pollard, S.J.T., E-mail: s.pollard@cranfield.ac.uk [Cranfield University, Centre for Environmental Risks and Futures, School of Applied Sciences, Cranfield MK43 0AL (United Kingdom)

    2014-01-01

    Complex regulatory decisions about risk rely on the brokering of evidence between providers and recipients, and involve personality and power relationships that influence the confidence that recipients may place in the sufficiency of evidence and, therefore, the decision outcome. We explore these relationships in an agent-based model; drawing on concepts from environmental risk science, decision psychology and computer simulation. A two-agent model that accounts for the sufficiency of evidence is applied to decisions about salt intake, animal carcass disposal and radioactive waste. A dynamic version of the model assigned personality traits to agents, to explore their receptivity to evidence. Agents with ‘aggressor’ personality sets were most able to imbue fellow agents with enhanced receptivity (with ‘avoider’ personality sets less so) and clear confidence in the sufficiency of evidence. In a dynamic version of the model, when both recipient and provider were assigned the ‘aggressor’ personality set, this resulted in 10 successful evidence submissions in 71 days, compared with 96 days when both agents were assigned the ‘avoider’ personality set. These insights suggest implications for improving the efficiency and quality of regulatory decision making by understanding the role of personality and power. - Highlights: •The role of personality and power in regulatory decision-making is poorly represented. •We built a rudimentary two-agent model to explore environmental risk decisions. •Our two agent model accounted for decisions about the sufficiency of evidence. •We examined the influence personality and power has on confidence gained. •By giving agents personality we might predict the time taken to reach consensus.

  1. Regulators as agents: Modelling personality and power as evidence is brokered to support decisions on environmental risk

    International Nuclear Information System (INIS)

    Complex regulatory decisions about risk rely on the brokering of evidence between providers and recipients, and involve personality and power relationships that influence the confidence that recipients may place in the sufficiency of evidence and, therefore, the decision outcome. We explore these relationships in an agent-based model; drawing on concepts from environmental risk science, decision psychology and computer simulation. A two-agent model that accounts for the sufficiency of evidence is applied to decisions about salt intake, animal carcass disposal and radioactive waste. A dynamic version of the model assigned personality traits to agents, to explore their receptivity to evidence. Agents with ‘aggressor’ personality sets were most able to imbue fellow agents with enhanced receptivity (with ‘avoider’ personality sets less so) and clear confidence in the sufficiency of evidence. In a dynamic version of the model, when both recipient and provider were assigned the ‘aggressor’ personality set, this resulted in 10 successful evidence submissions in 71 days, compared with 96 days when both agents were assigned the ‘avoider’ personality set. These insights suggest implications for improving the efficiency and quality of regulatory decision making by understanding the role of personality and power. - Highlights: •The role of personality and power in regulatory decision-making is poorly represented. •We built a rudimentary two-agent model to explore environmental risk decisions. •Our two agent model accounted for decisions about the sufficiency of evidence. •We examined the influence personality and power has on confidence gained. •By giving agents personality we might predict the time taken to reach consensus

  2. Pilot study on developing a decision support tool for guiding re-administration of chemotherapeutic agent after a serious adverse drug reaction

    Directory of Open Access Journals (Sweden)

    Chew Lita

    2011-07-01

    Full Text Available Abstract Background Currently, there are no standard guidelines for recommending re-administration of a chemotherapeutic drug to a patient after a serious adverse drug reaction (ADR incident. The decision on whether to rechallenge the patient is based on the experience of the clinician and is highly subjective. Thus the aim of this study is to develop a decision support tool to assist clinicians in this decision making process. Methods The inclusion criteria for patients in this study are: (1 had chemotherapy at National Cancer Centre Singapore between 2004 to 2009, (2 suffered from serious ADRs, and (3 were rechallenged. A total of 46 patients fulfilled the inclusion criteria. A genetic algorithm attribute selection method was used to identify clinical predictors for patients' rechallenge status. A Naïve Bayes model was then developed using 35 patients and externally validated using 11 patients. Results Eight patient attributes (age, chemotherapeutic drug, albumin level, red blood cell level, platelet level, abnormal white blood cell level, abnormal alkaline phosphatase level and abnormal alanine aminotransferase level were identified as clinical predictors for rechallenge status of patients. The Naïve Bayes model had an AUC of 0.767 and was found to be useful for assisting clinical decision making after clinicians had identified a group of patients for rechallenge. A platform independent version and an online version of the model is available to facilitate independent validation of the model. Conclusion Due to the limited size of the validation set, a more extensive validation of the model is necessary before it can be adopted for routine clinical use. Once validated, the model can be used to assist clinicians in deciding whether to rechallenge patients by determining if their initial assessment of rechallenge status of patients is accurate.

  3. Current Evidence for Extracorporeal Liver Support Systems in Acute Liver Failure and Acute-on-Chronic Liver Failure.

    Science.gov (United States)

    Karvellas, Constantine J; Subramanian, Ram M

    2016-07-01

    Artificial (nonbiological) extracorporeal liver support devices aim to remove albumin-bound and water-soluble toxins to restore and preserve hepatic function and mitigate or limit the progression of multiorgan failure while hepatic recovery or liver transplant occurs. The following beneficial effects have been documented: improvement of jaundice, amelioration of hemodynamic instability, reduction of portal hypertension, and improvement of hepatic encephalopathy. The only randomized prospective multicenter controlled trial to show an improvement in transplant-free survival was for high-volume plasmapheresis. Biological (cell-based) extracorporeal liver support systems aim to support the failing liver through detoxification and synthetic function and warrant further study for safety and benefit. PMID:27339682

  4. Implementing an evidence-based computerized decision support system to improve patient care in a general hospital: the CODES study protocol for a randomized controlled trial

    OpenAIRE

    Moja, Lorenzo; Polo Friz, Hernan; Capobussi, Matteo; Kwag, Koren; Banzi, Rita; Ruggiero, Francesca; González-Lorenzo, Marien; Liberati, Elisa Giulia; Mangia, Massimo; Nyberg, Peter; Kunnamo, Ilkka; Cimminiello, Claudio; Vighi, Giuseppe; Grimshaw, Jeremy; Bonovas, Stefanos

    2016-01-01

    Background Computerized decision support systems (CDSSs) are information technology-based software that provide health professionals with actionable, patient-specific recommendations or guidelines for disease diagnosis, treatment, and management at the point-of-care. These messages are intelligently filtered to enhance the health and clinical care of patients. CDSSs may be integrated with patient electronic health records (EHRs) and evidence-based knowledge. Methods/design We designed a pragm...

  5. Assessing the ability of health information systems in hospitals to support evidence-informed decisions in Kenya

    OpenAIRE

    Kihuba, Elesban; Gathara, David; Mwinga, Stephen; Mulaku, Mercy; Kosgei, Rose; Mogoa, Wycliffe; Nyamai, Rachel; English, Mike

    2014-01-01

    Background: Hospital management information systems (HMIS) is a key component of national health information systems (HIS), and actions required of hospital management to support information generation in Kenya are articulated in specific policy documents. We conducted an evaluation of core functions of data generation and reporting within hospitals in Kenya to facilitate interpretation of national reports and to provide guidance on key areas requiring improvement to support data use in decis...

  6. Evidence on Inclusion and Support for Learners with Disabilities in Mainstream Schools in South Africa: Off the Policy Radar?

    Science.gov (United States)

    Pather, Sulochini

    2011-01-01

    Since the move towards inclusion in line with international trends and South Africa's attempts to address issues of marginalisation and discrimination amongst all learners, including those with special needs and disabilities, it has become evident on perusal of various research studies and reviews that there is an obsession with how far we have…

  7. Supporting employees' work-family needs improves health care quality: Longitudinal evidence from long-term care.

    Science.gov (United States)

    Okechukwu, Cassandra A; Kelly, Erin L; Bacic, Janine; DePasquale, Nicole; Hurtado, David; Kossek, Ellen; Sembajwe, Grace

    2016-05-01

    We analyzed qualitative and quantitative data from U.S.-based employees in 30 long-term care facilities. Analysis of semi-structured interviews from 154 managers informed quantitative analyses. Quantitative data include 1214 employees' scoring of their supervisors and their organizations on family supportiveness (individual scores and aggregated to facility level), and three outcomes: (1), care quality indicators assessed at facility level (n = 30) and collected monthly for six months after employees' data collection; (2), employees' dichotomous survey response on having additional off-site jobs; and (3), proportion of employees with additional jobs at each facility. Thematic analyses revealed that managers operate within the constraints of an industry that simultaneously: (a) employs low-wage employees with multiple work-family challenges, and (b) has firmly institutionalized goals of prioritizing quality of care and minimizing labor costs. Managers universally described providing work-family support and prioritizing care quality as antithetical to each other. Concerns surfaced that family-supportiveness encouraged employees to work additional jobs off-site, compromising care quality. Multivariable linear regression analysis of facility-level data revealed that higher family-supportive supervision was associated with significant decreases in residents' incidence of all pressure ulcers (-2.62%) and other injuries (-9.79%). Higher family-supportive organizational climate was associated with significant decreases in all falls (-17.94%) and falls with injuries (-7.57%). Managers' concerns about additional jobs were not entirely unwarranted: multivariable logistic regression of employee-level data revealed that among employees with children, having family-supportive supervision was associated with significantly higher likelihood of additional off-site jobs (RR 1.46, 95%CI 1.08-1.99), but family-supportive organizational climate was associated with lower likelihood

  8. A learning collaborative supporting the implementation of an evidence-informed program, the "4Rs and 2Ss for children with conduct difficulties and their families".

    Science.gov (United States)

    Stephens, Tricia N; McGuire-Schwartz, Mandy; Rotko, Lauren; Fuss, Ashley; McKay, Mary M

    2014-01-01

    In this qualitative study the authors examine factors associated with the successful implementation and plans for continued use of an evidence-informed intervention, the 4Rs and 2Ss Program for Strengthening Families, in a sample of 29 New York State, Office of Mental Health licensed child mental health clinics. A learning collaborative (LC) approach was used as a vehicle for supporting training and implementation of the program. The PRISM theoretical framework ( Feldstein & Glasgow, 2008 ) was used to guide the data analysis. Data were analyzed using a multi-phase iterative process, identifying influences on implementation at multiple levels: the program (intervention), the external environment, implementation and sustainability infrastructure, and recipient characteristics. Clinics that were more proactive evidenced staff with advanced organizational skills were able to take advantage of the trainings and supports offered by the LC and fared better in their ability to adopt the intervention. The ability to adapt the intervention to the specific constraints of the clinics was a strong influence on continued use following the end of the LC. These preliminary results suggest that the supports provided by the LC are useful in consolidating information about the process of implementing evidence-informed interventions in community mental health settings. The impact of these supports is also based on their interactions with specific clinic contextual factors. PMID:25491005

  9. Strengthening the food systems governance evidence base: Supporting commensurability of research through a systematic review of methods

    OpenAIRE

    Delaney, Aogán; Evans, Tom; McGreevy, John; Blekking, Jordan; Schlachter, Tyler; Korhonen-Kurki, Kaisa; Tamás, Peter A.; Todd A. Crane; Eakin, Hallie; Förch, Wiebke; Jones, Lindsey; Donald R. Nelson; Oberlack, Christoph; Purdon, Mark

    2016-01-01

    Governance of food systems is a poorly understood determinant of food security. Much scholarship on food systems governance is non-empirical, while existing research is often case study-based and theoretically and methodologically incommensurable. This frustrates aggregation of evidence and generalisation. We undertook a systematic review of methods used in food systems governance research with a view to identifying a core set of indicators for future research. We gathered literature through ...

  10. The Interaction between Financial Incentives and Task-specific Cognitive Capital : More Evidence in Support of Camerer and Hogarth (1999)

    OpenAIRE

    Rydval, Ondřej

    2007-01-01

    This paper extends existing evidence on the interaction between financial incentives and cognitive capital. I focus on the impact of task-specific cognitive capital, the role of which is central to the capital-labor-production framework of Camerer and Hogarth (1999) and has long been studied in cognitive science and behavioral decision research. Using a task situated in an accounting setting, I show that both financial incentives and task-specific cognitive capital, and especially their inter...

  11. Capital and Labor Effects in a Recall Task: More Evidence in Support of Camerer and Hogarth (1999)

    OpenAIRE

    Ondrej Rydval

    2005-01-01

    This paper extends existing evidence on the interaction and relative productivity of cognitive effort and cognitive capital in an experimental environment. I focus on the impact of task-specific cognitive capital, which is central to the capital-labor argument of Camerer and Hogarth (1999) as well as related research in cognitive science and behavioral decision making. Using a memory recall task situated in an accounting setting, I show that the impact of taskspecific accounting knowledge on ...

  12. The use of evidence-based outcomes in systems and organizations providing services and supports to persons with intellectual disability.

    Science.gov (United States)

    van Loon, Jos H M; Bonham, Gordon S; Peterson, Dale D; Schalock, Robert L; Claes, Claudia; Decramer, Adelien E M

    2013-02-01

    This article describes how evidence-based outcomes (EBOs) can be used to improve clinical, managerial, and policy decisions. As a component of evidence-based practices, EBOs are defined as measures obtained from the assessment of quality of life-related indicators that are based on a cross-culturally validated quality of life conceptual and measurement model, have utility in that they can be used for multiple purposes, and have robustness in reference to reliability and validity of the assessment strategy employed. A 5-component EBO model is described that provides a framework for the activities involved in selecting, developing, and implementing evidence-based outcomes. Three international examples based on the reliable, valid, and standardized assessment of individual quality of life outcomes are presented that demonstrate how EBOs can be used to improve clinical, managerial, and policy decision making. The article concludes with a discussion of guidelines for developing and using EBOs, and the challenges involved in their use. PMID:22982162

  13. SIAT: Information system of support to the administration of technology; SIAT: Sistema de informacion de apoyo a la administracion de la tecnologia

    Energy Technology Data Exchange (ETDEWEB)

    Molina Gonzalez, Ricardo; Herrera Lavin, Jesus; Rodriguez Ortiz, Guillermo [Instituto de Investigaciones Electricas, Temixco, Morelos (Mexico)

    1999-07-01

    A general introduction is made of the administration problem of the technology and a brief description of the process implemented in Petroleos Mexicanos (PEMEX) Exploration and Production (PEP) for the administration of the technology in PEP and the benefits that it provides. [Spanish] Se presenta una introduccion general del problema de administracion de la tecnologia y una breve descripcion del proceso implantado en Petroleos Mexicanos (Pemex) Exploracion y Produccion (PEP) para la administracion de las tecnologias en PEP y los beneficios que proporciona.

  14. The Effects of Principal's Leadership Style on Support for Innovation: Evidence from Korean Vocational High School Change

    Science.gov (United States)

    Park, Joo-Ho

    2012-01-01

    A climate of innovation and principal leadership in schools are regarded as significant factors in successfully implementing school change or innovation. Nevertheless, the relationship between the school climate supportive of innovation and the principal's leadership has rarely been addressed to determine whether schools successfully perform their…

  15. Translation of Evidence-Based Practices in a Behaviour Support Implementation Model for Youth with Autism Spectrum Disorders

    Science.gov (United States)

    Lyons, Gregory

    2011-01-01

    Linda Miller describes a model for the practical implementation of behaviour supports. This model, the "5P approach", attempts to delineate a comprehensive and sequentially-stepped model of the assessment and treatment of challenging behaviour with consistent colour-coded themes. The 5Ps include profiling the child, prioritising the challenging…

  16. Risk Aversion and Support for Merit Pay: Theory and Evidence from Minnesota's Q Comp Program. Working Paper #09-05

    Science.gov (United States)

    Nadler, Carl; Wiswall, Matthew

    2009-01-01

    Recent research attributes the lack of merit pay in teaching to the resistance of teachers. This paper examines whether the structure of merit pay affects the types of teachers who support it. We develop a model of the relative utility teachers receive from merit pay versus the current fixed schedule of raises. We show that if teachers are risk…

  17. The Dopamine D2 Receptor Gene, Perceived Parental Support, and Adolescent Loneliness: Longitudinal Evidence for Gene-Environment Interactions

    Science.gov (United States)

    van Roekel, Eeske; Goossens, Luc; Scholte, Ron H. J.; Engels, Rutger C. M. E.; Verhagen, Maaike

    2011-01-01

    Background: Loneliness is a common problem in adolescence. Earlier research focused on genes within the serotonin and oxytocin systems, but no studies have examined the role of dopamine-related genes in loneliness. In the present study, we focused on the dopamine D2 receptor gene (DRD2). Methods: Associations among the DRD2, sex, parental support,…

  18. Do Education and Income Affect Support for Democracy in Muslim Countries? Evidence from the "Pew Global Attitudes Project"

    Science.gov (United States)

    Shafiq, M. Najeeb

    2010-01-01

    Using micro-level public opinion data from the "Pew Global Attitudes Project 2005", this study investigates the effect of educational attainment and income on support for democracy in five predominantly Muslim countries: Indonesia, Jordan, Lebanon, Pakistan, and Turkey. Holding all else constant and compared to not finishing primary education,…

  19. The Weight of Evidence Does Not Support the Listing of Styrene as "Reasonably Anticipated to be a Human Carcinogen" in NTP's Twelfth Report on Carcinogens.

    Science.gov (United States)

    Rhomberg, Lorenz R; Goodman, Julie E; Prueitt, Robyn L

    2013-01-01

    Styrene was listed as "reasonably anticipated to be a human carcinogen" in the twelfth edition of the National Toxicology Program's Report on Carcinogens based on what we contend are erroneous findings of limited evidence of carcinogenicity in humans, sufficient evidence of carcinogenicity in experimental animals, and supporting mechanistic data. The epidemiology studies show no consistent increased incidence of, or mortality from, any type of cancer. In animal studies, increased incidence rates of mostly benign tumors have been observed only in certain strains of one species (mice) and at one tissue site (lung). The lack of concordance of tumor incidence and tumor type among animals (even within the same species) and humans indicates that there has been no particular cancer consistently observed among all available studies. The only plausible mechanism for styrene-induced carcinogenesis-a non-genotoxic mode of action that is specific to the mouse lung-is not relevant to humans. As a whole, the evidence does not support the characterization of styrene as "reasonably anticipated to be a human carcinogen," and styrene should not be listed in the Report on Carcinogens. PMID:23335843

  20. Towards a European Strategy in Support of Innovation in Services A review of key evidence and policy issues

    OpenAIRE

    Rubalcaba, Luis; Hipp, Christiane; Gallouj, Faïz; Fornhal, Dirk

    2008-01-01

    This report focuses on service innovation and the conditions in which service innovation can be promoted in European policies. The authors want to reinforce the current plans towards a European strategy in Support of Innovation in Services -SEC(2007) 1059 - within the preparatory works for the forthcoming communication in services innovation (expected for fall 2008). This work has been prepared under the framework contract between the European Commission – DG Enterprise and Industry - and TNO...

  1. The association of unwanted pregnancy and social support with depressive symptoms in pregnancy: evidence from rural Southwestern Ethiopia

    OpenAIRE

    Dibaba, Yohannes; Fantahun, Mesganaw; Hindin, Michelle J

    2013-01-01

    Background Depression in pregnancy has adverse health outcomes for mothers and children. The magnitude and risk factors of maternal depression during pregnancy is less known in developing countries. This study examines the association between pregnancy intention, social support and depressive symptoms in pregnancy in Ethiopia. Methods Data for this study comes from a baseline survey conducted as part of a community- based cohort study that involved 627 pregnant women from a Demographic Survei...

  2. What is the evidence to support home environmental adaptation in Parkinson's disease? A call for multidisciplinary interventions.

    Science.gov (United States)

    Bhidayasiri, Roongroj; Jitkritsadakul, Onanong; Boonrod, Nonglak; Sringean, Jirada; Calne, Susan M; Hattori, Nobutaka; Hayashi, Akito

    2015-10-01

    "Home" is where one has a sense of belonging and feels secure, but it can also be a risky place for people with Parkinson's disease (PD). PD patients need assistance making adjustments to their physical environment to maintain appropriate care and provide a safe environment. This relationship is called the "person-environmental fit" (P-E fit). While most PD patients remain in their own homes, little is known about the specific challenges that PD patients and their caregivers encounter in the routine activities of daily living. The aim of our study was to identify the existing evidence on the issue of housing environmental adaptation in PD by performing a systematic review with a proposal of development strategies to integrate a multidisciplinary team into a home environmental research. MEDLINE, and life science journals were searched by querying appropriate key words, but revealed very few publications in this area. However, early evidence suggested that PD patients do not enjoy an adequate P-E fit in their own homes and face more functional limitations compared to matched controls. We concluded that we need to develop research-based evaluation strategies that can provide us with a theoretical and conceptual basis as well as tools for analysis of the P-E fit for PD patients and caregivers. We recommend that individual members of the multidisciplinary team including patients, caregivers, physicians, rehabilitation specialists, and social workers use a team approach to identify the key indicators and solutions for the development of PD-specific solutions for improving the P-E fit. PMID:26365779

  3. Iron isotopes in ancient and modern komatiites: Evidence in support of an oxidised mantle from Archean to present

    Science.gov (United States)

    Hibbert, K. E. J.; Williams, H. M.; Kerr, A. C.; Puchtel, I. S.

    2012-03-01

    The mantle of the modern Earth is relatively oxidised compared to the initially reducing conditions inferred for core formation. The timing of the oxidation of the mantle is not conclusively resolved but has important implications for the timing of the development of the hydrosphere and atmosphere. In order to examine the timing of this oxidation event, we present iron isotope data from three exceptionally well preserved komatiite localities, Belingwe (2.7 Ga), Vetreny (2.4 Ga) and Gorgona (0.089 Ga). Measurements of Fe isotope compositions of whole-rock samples are complemented by the analysis of olivine, spinel and pyroxene separates. Bulk-rock and olivine Fe isotope compositions (δ57Fe) define clear linear correlations with indicators of magmatic differentiation (Mg#, Cr#). The mean Fe isotope compositions of the 2.7-2.4 Ga and 0.089 Ga samples are statistically distinct and this difference can be explained by greater extent of partial melting represented by the older samples and higher mantle ambient temperatures in the Archean and early Proterozoic relative to the present day. Significantly, samples of all ages define continuous positive linear correlations between bulk rock δ57Fe and V/Sc and δ57Fe and V, and between V/Sc and V with TiO2, providing evidence for the incompatible behaviour of V (relative to Sc) and of isotopically heavy Fe. Partial melting models calculated using partition coefficients for V at oxygen fugacities (fO2s) of 0 and + 1 relative to the fayalite-magnetite-quartz buffer (FMQ) best match the data arrays, which are defined by all samples, from late Archean to Tertiary. These data, therefore, provide evidence for komatiite generation under moderately oxidising conditions since the late Archean, and argue against a change in mantle fO2 concomitant with atmospheric oxygenation at ~ 2.4 Ga.

  4. Assessing the ability of health information systems in hospitals to support evidence-informed decisions in Kenya

    Directory of Open Access Journals (Sweden)

    Elesban Kihuba

    2014-07-01

    Full Text Available Background: Hospital management information systems (HMIS is a key component of national health information systems (HIS, and actions required of hospital management to support information generation in Kenya are articulated in specific policy documents. We conducted an evaluation of core functions of data generation and reporting within hospitals in Kenya to facilitate interpretation of national reports and to provide guidance on key areas requiring improvement to support data use in decision making. Design: The survey was a cross-sectional, cluster sample study conducted in 22 hospitals in Kenya. The statistical analysis was descriptive with adjustment for clustering. Results: Most of the HMIS departments complied with formal guidance to develop departmental plans. However, only a few (3/22 had carried out a data quality audit in the 12 months prior to the survey. On average 3% (range 1–8% of the total hospital income was allocated to the HMIS departments. About half of the records officer positions were filled and about half (13/22 of hospitals had implemented some form of electronic health record largely focused on improving patient billing and not linked to the district HIS. Completeness of manual patient registers varied, being 90% (95% CI 80.1–99.3%, 75.8% (95% CI 68.7–82.8%, and 58% (95% CI 50.4–65.1% in maternal child health clinic, maternity, and pediatric wards, respectively. Vital events notification rates were low with 25.7, 42.6, and 71.3% of neonatal deaths, infant deaths, and live births recorded, respectively. Routine hospital reports suggested slight over-reporting of live births and under-reporting of fresh stillbirths and neonatal deaths. Conclusions: Study findings indicate that the HMIS does not deliver quality data. Significant constraints exist in data quality assurance, supervisory support, data infrastructure in respect to information and communications technology application, human resources, financial

  5. Enhanced central serotonin release from slices of rat hypothalamus following repeated nialamide administration: evidence supporting the overactive serotonin receptor theory of depression

    International Nuclear Information System (INIS)

    Researchers are suggesting unipolar affective disorders may be related to an abnormality in biogenic amine receptor-sensitivity. This abnormality may be a result of a dysfunction in central serotonin (5-HT) release mechanisms. 5-HT neurotransmission is modulated by presynaptic autoreceptors, which are members of the 5-HT1 receptor subtype. The autoreceptor is thought to play an important role in the homeostasis of the central 5-HT synapse and could be a site at which some antidepressants mediate their therapeutic effect. The number of 5-HT1 type receptor binding sites are reduced and behavior mediated by this receptor is abolished following repeated injections of monoamine oxidase inhibitor type antidepressants. These changes did not occur following a single injection. It was hypothesized that repeated treatment with a monoamine oxidase inhibitor would reduce the sensitivity of 5-HT autoreceptors and enhance 5-HT release. Rats were pretreated with single or repeated (twice daily for 7 days) intraperitoneal injections of nialamide (40 mg/kg) or chlorimipramine (10 mg/kg) and the ability of the autoreceptor agonist to inhibit potassium-induced 3H-5-HT release was evaluated using an in vitro superfusion system. These changes in 5-HT autoreceptor activity are consistent with other reports evaluating monoamine oxidase inhibitors on 5-HT1 type receptors. It is hypothesized that the changes in 5-HT neurotransmission are related to the antidepressant mechanism of monoamine oxidase inhibitors

  6. Administration for Community Living

    Science.gov (United States)

    ... 04/30/2016) New CDC Autism Data Highlights Importance of Long-term Services and Supports, Cultural Competency ( ... STAY CONNECTED Facebook Twitter YouTube E-mail Updates Administration for Community Living • Washington, DC 20201 Last Modified: ...

  7. Self Assessment in Higher Education: An Empirical Evidence from the Department of Business Administration of Shahjalal University of Science and Technology, Bangladesh

    Science.gov (United States)

    Islam, Nazrul; Chowdhury, Mohmmad Ashraful Ferdous

    2015-01-01

    The paper aimed to explore the self assessment practices in higher education in Bangladesh with special reference to Department of Business Administration of Shahjalal University of Science and Technology. For self assessment purpose the researchers have collected opinion from students, alumni, employer and faculty members on eight areas. In…

  8. Strong evidence for terrestrial support of zooplankton in small lakes based on stable isotopes of carbon, nitrogen, and hydrogen

    Science.gov (United States)

    Cole, J.J.; Carpenter, S.R.; Kitchell, J.; Pace, M.L.; Solomon, C.T.; Weidel, B.

    2011-01-01

    Cross-ecosystem subsidies to food webs can alter metabolic balances in the receiving (subsidized) system and free the food web, or particular consumers, from the energetic constraints of local primary production. Although cross-ecosystem subsidies between terrestrial and aquatic systems have been well recognized for benthic organisms in streams, rivers, and the littoral zones of lakes, terrestrial subsidies to pelagic consumers are more difficult to demonstrate and remain controversial. Here, we adopt a unique approach by using stable isotopes of H, C, and N to estimate terrestrial support to zooplankton in two contrasting lakes. Zooplankton (Holopedium, Daphnia, and Leptodiaptomus) are comprised of ???20-40% of organic material of terrestrial origin. These estimates are as high as, or higher than, prior measures obtained by experimentally manipulating the inorganic 13C content of these lakes to augment the small, natural contrast in 13C between terrestrial and algal photosynthesis. Our study gives credence to a growing literature, which we review here, suggesting that significant terrestrial support of pelagic crustaceans (zooplankton) is widespread.

  9. A Reference-Intensive Embedded Librarian Program: Kresge Business Administration Library's Program to Support Action-Based Learning at the Ross School of Business

    Science.gov (United States)

    Berdish, Laura; Seeman, Corey

    2010-01-01

    While a great deal of literature on embedded librarians in academic libraries is focused on the role of instructor, there are many other services that could be provided by librarians working closely with students. The Kresge Business Administration Library (Stephen M. Ross School of Business at the University of Michigan) has created a unique…

  10. Evidence of the effect of dipyrone on the central nervous system as a determinant of delayed gastric emptying observed in rats after its administration

    Directory of Open Access Journals (Sweden)

    Collares E.F.

    2003-01-01

    Full Text Available Dipyrone administered intravenously (iv delays gastric emptying (GE in rats. The objectives of the present study were to assess: 1 the effect of the dose of dipyrone and time after its iv administration on GE in rats, 2 the effect of subdiaphragmatic vagotomy (VgX and bilateral electrolytic lesion of the paraventricular nucleus (PVNX on the delayed GE induced by the drug, and 3 the intracerebroventricular (icv action of dipyrone and of one of its metabolites, 4-aminoantipyrine on GE. Male Wistar rats received saline labeled with phenol red intragastrically as a test meal. GE was indirectly assessed by the determination of percent gastric retention (GR of the test meal 10 min after administration by gavage. Dipyrone delays GE in a dose- and time-dependent manner. Thirty minutes after the iv administration of 80 mg/kg dipyrone, the animals showed significantly higher GR (mean = 62.6% compared to those receiving vehicle (31.5%. VgX and PVNX significantly reduced the iv effect of 80 mg/kg dipyrone (mean %GR: VgX = 28.3 vs Sham = 55.5 and PVNX = 34.5 vs Sham = 52.2. Icv administration of 4 µmol dipyrone caused a significant increase in GR (54.1% of the test meal 10 min later, whereas administration of 4 µmol 4-aminoantipyrine had no effect (34.4%. Although the dipyrone dose administered icv was 16 times lower than that applied iv, for the same time of action (10 min, the GR of animals that received the drug icv (54.1% or iv (54.5% did not differ significantly. In conclusion, the present results suggest that the effect of dipyrone in delaying GE is due to the action of the drug on the central nervous system, with the participation of the PVN and of the vagus nerve.

  11. SOURCES OF FINANCING EUROPEAN SMES AND NEW SUPPORTING EU POLICIES: EVIDENCE FROM THE NEW EU MEMBER STATES

    Directory of Open Access Journals (Sweden)

    ANGELA ROMAN

    2012-05-01

    Full Text Available The SMEs’ access to finance is crucial for the creation, survival and growth of these firms. In the light of the recent global crisis, the dramatic fall in demand for goods and services and the reduced availability of bank loans has led to the aggravation of the problems faced by SMEs when they prospect for purchasing financial resources. In this context, our paper aims to highlight the sources of financing used by the European SMEs and the new policies proposed by the European Commission to facilitate their access to finance. The analysis carried out in this paper is based on data and statistics provided mainly by the European Commission and the World Bank. Based on the methodology used, the paper mainly indicates, the major problems regarding the financing opportunities faced by SMEs and the indispensable necessity for the adoption of measures, especially at EU level, to support their access to finance.

  12. Integration of Epidemiological Evidence in a Decision Support Model for the Control of Campylobacter in Poultry Production

    DEFF Research Database (Denmark)

    Garcia Clavero, Ana Belén; Madsen, Anders L.; Vigre, Håkan

    2013-01-01

    decision support systems are constructed as probabilistic graphical models (PGMs) which integrate knowledge and use Bayesian methods to deal with uncertainty. This paper presents a specific model designed to integrate epidemiological knowledge from the United Kingdom (UK model) in order to assist poultry...... were no or only small financial gains when using a hypothetical vaccine B (able to decrease Campylobacter numbers from two to six logs in 20% of the chickens with a cost of 0.025 £/chicken) and reward system 1 (based on similar gross profits in relation to Campylobacter levels) under the specific...... more than one reward system and consequently, diverse potential solutions for the control of Campylobacter may be considered. Cost-effective Campylobacter control strategies that can significantly reduce the probability of Campylobacter introduction into a flock and/or the numbers of Campylobacter in...

  13. Resolved H I observations of local analogs to z ~ 1 luminous compact blue galaxies: evidence for rotation-supported disks

    CERN Document Server

    Rabidoux, Katie; Garland, C A; Guzman, Rafael; Castander, Francisco J; Wolfe, Spencer

    2014-01-01

    While bright, blue, compact galaxies are common at $\\rm z \\sim 1$, they are relatively rare in the local universe, and their evolutionary paths are uncertain. We have obtained resolved H I observations of nine $\\rm z \\sim 0$ luminous compact blue galaxies (LCBGs) using the Giant Metrewave Radio Telescope and Very Large Array in order to measure their kinematic and dynamical properties and better constrain their evolutionary possibilities. We find that the LCBGs in our sample are rotating galaxies that tend to have nearby companions, relatively high central velocity dispersions, and can have disturbed velocity fields. We compare our measurements to those previously made with single dishes and find that single dish measurements tend to overestimate LCBGs' rotation velocities and H I masses. We also compare the ratio of LCBGs' rotation velocities to their velocity dispersions to those of other types of galaxies and find that LCBGs are strongly rotationally supported at large radii, similar to other types of disk...

  14. Preclinical evidence supporting the clinical development of central pattern generator-modulating therapies for chronic spinal cord-injured patients

    Directory of Open Access Journals (Sweden)

    Pierre eGuertin

    2014-05-01

    Full Text Available Ambulation or walking is one of the main gaits of locomotion. In terrestrial animals, it may be defined as a series of rhythmic and bilaterally coordinated movement of the limbs which creates a forward movement of the body. This applies regardless of the number of limbs - from arthropods with six or more limbs to bipedal primates. These fundamental similarities among species may explain why comparable neural systems and cellular properties have been found, thus far, to control in similar ways locomotor rhythm generation in most animal models. The aim of this article is to provide a comprehensive review of the known structural and functional features associated with central nervous system (CNS networks that are involved in the control of ambulation and other stereotyped motor patterns - specifically Central Pattern Generators (CPGs that produce basic rhythmic patterned outputs for locomotion, micturition, ejaculation, and defecation. Although there is compelling evidence of their existence in humans, CPGs have been most studied in reduced models including in vitro isolated preparations, genetically-engineered mice and spinal cord-transected animals. Compared with other structures of the CNS, the spinal cord is generally considered as being well-preserved phylogenetically. As such, most animal models of SCI should be considered as valuable tools for the development of novel pharmacological strategies aimed at modulating spinal activity and restoring corresponding functions in chronic spinal cord-injured patients.

  15. Evidence for Stopping Mass Drug Administration for Lymphatic Filariasis in Some, But Not All Local Government Areas of Plateau and Nasarawa States, Nigeria

    OpenAIRE

    King, Jonathan D.; Eigege, Abel; Umaru, John; Jip, Nimzing; Miri, Emmanuel; Jiya, Jonathan; Alphonsus, Kal M.; Sambo, Yohanna; Graves, Patricia; Richards, Frank

    2012-01-01

    An average of six annual rounds of ivermectin and albendazole were distributed in Plateau and Nasarawa States, Nigeria, to eliminate lymphatic filariasis. From 2007 to 2008, population-based surveys were implemented in all 30 local government areas (LGAs) of the two states to determine the prevalence of Wuchereria bancrofti antigenemia to assess which LGA mass drug administration (MDA) could be halted. In total, 36,681 persons from 7,819 households were examined for filarial antigen as determ...

  16. Does mass drug administration for the integrated treatment of neglected tropical diseases really work? Assessing evidence for the control of schistosomiasis and soil-transmitted helminths in Uganda

    OpenAIRE

    Allen Tim; Parker Melissa

    2011-01-01

    This paper was one of four papers commissioned to review the role of social sciences in NTD control by TDR, the Special Programme for Research and Training on Tropical Diseases, which is executed by WHO and co-sponsored by UNICEF, UNDP, the World Bank and WHO. This article has been made available through the Brunel Open Access Publishing Fund. Background: Less is known about mass drug administration [MDA] for neglected tropical diseases [NTDs] than is suggested by those so vigorously pr...

  17. The Right Hemisphere Planum Temporale Supports Enhanced Visual Motion Detection Ability in Deaf People: Evidence from Cortical Thickness.

    Science.gov (United States)

    Shiell, Martha M; Champoux, François; Zatorre, Robert J

    2016-01-01

    After sensory loss, the deprived cortex can reorganize to process information from the remaining modalities, a phenomenon known as cross-modal reorganization. In blind people this cross-modal processing supports compensatory behavioural enhancements in the nondeprived modalities. Deaf people also show some compensatory visual enhancements, but a direct relationship between these abilities and cross-modally reorganized auditory cortex has only been established in an animal model, the congenitally deaf cat, and not in humans. Using T1-weighted magnetic resonance imaging, we measured cortical thickness in the planum temporale, Heschl's gyrus and sulcus, the middle temporal area MT+, and the calcarine sulcus, in early-deaf persons. We tested for a correlation between this measure and visual motion detection thresholds, a visual function where deaf people show enhancements as compared to hearing. We found that the cortical thickness of a region in the right hemisphere planum temporale, typically an auditory region, was greater in deaf individuals with better visual motion detection thresholds. This same region has previously been implicated in functional imaging studies as important for functional reorganization. The structure-behaviour correlation observed here demonstrates this area's involvement in compensatory vision and indicates an anatomical correlate, increased cortical thickness, of cross-modal plasticity. PMID:26885405

  18. Hydrogeochemical Investigations Supported By Isotopic Evidences: The Quaternary Aquifer in Wadi Na'Man Basin, Western Province of Saudi Arabia

    International Nuclear Information System (INIS)

    The groundwater of the Quaternary aquifer in Wadi Na'man basin displays different hydrogeochemical environments. The salinity reflects fresh to saline characters (TDS ranges from 384 mg/l to 6190 mg/l) and ph reflects slightly acidic to alkaline nature (range from 6.9 and 8.1). Certain hydrogeochemical processes were detected in the present study which plays the essential role for the groundwater evolution and contamination under the prevailing arid climate with occasional rainfall events. The present investigations are based on the distribution trends of the binary relationships of Cl- ions and its ionic ratios with Br-, Na+, K+ Ca++and Mg++ ions. They reveal the potential of the hydrogeochemical processes such as the evaporation, the leaching and dissolution and silicate weathering. They reflect the influence of natural hydrogeological factors as well as the man-made factors. The increase of K+ and NO3 ions concentrations in the groundwater confirms the potential of fertilizing and primitive sewerage effluent. The present investigated trends of variation of stable isotopes (D and 18O) in the groundwater and rain water in the basin confirm the potential of the detected hydrogeochemical processes and factors. The tritium concentrations and stable isotope data support the direct connection between the different parts of the aquifer from the upper to lower reaches of the basin as well as renewal recharge with the recently local rainfall after 1952.

  19. The Right Hemisphere Planum Temporale Supports Enhanced Visual Motion Detection Ability in Deaf People: Evidence from Cortical Thickness

    Directory of Open Access Journals (Sweden)

    Martha M. Shiell

    2016-01-01

    Full Text Available After sensory loss, the deprived cortex can reorganize to process information from the remaining modalities, a phenomenon known as cross-modal reorganization. In blind people this cross-modal processing supports compensatory behavioural enhancements in the nondeprived modalities. Deaf people also show some compensatory visual enhancements, but a direct relationship between these abilities and cross-modally reorganized auditory cortex has only been established in an animal model, the congenitally deaf cat, and not in humans. Using T1-weighted magnetic resonance imaging, we measured cortical thickness in the planum temporale, Heschl’s gyrus and sulcus, the middle temporal area MT+, and the calcarine sulcus, in early-deaf persons. We tested for a correlation between this measure and visual motion detection thresholds, a visual function where deaf people show enhancements as compared to hearing. We found that the cortical thickness of a region in the right hemisphere planum temporale, typically an auditory region, was greater in deaf individuals with better visual motion detection thresholds. This same region has previously been implicated in functional imaging studies as important for functional reorganization. The structure-behaviour correlation observed here demonstrates this area’s involvement in compensatory vision and indicates an anatomical correlate, increased cortical thickness, of cross-modal plasticity.

  20. The Right Hemisphere Planum Temporale Supports Enhanced Visual Motion Detection Ability in Deaf People: Evidence from Cortical Thickness

    Science.gov (United States)

    Shiell, Martha M.; Champoux, François; Zatorre, Robert J.

    2016-01-01

    After sensory loss, the deprived cortex can reorganize to process information from the remaining modalities, a phenomenon known as cross-modal reorganization. In blind people this cross-modal processing supports compensatory behavioural enhancements in the nondeprived modalities. Deaf people also show some compensatory visual enhancements, but a direct relationship between these abilities and cross-modally reorganized auditory cortex has only been established in an animal model, the congenitally deaf cat, and not in humans. Using T1-weighted magnetic resonance imaging, we measured cortical thickness in the planum temporale, Heschl's gyrus and sulcus, the middle temporal area MT+, and the calcarine sulcus, in early-deaf persons. We tested for a correlation between this measure and visual motion detection thresholds, a visual function where deaf people show enhancements as compared to hearing. We found that the cortical thickness of a region in the right hemisphere planum temporale, typically an auditory region, was greater in deaf individuals with better visual motion detection thresholds. This same region has previously been implicated in functional imaging studies as important for functional reorganization. The structure-behaviour correlation observed here demonstrates this area's involvement in compensatory vision and indicates an anatomical correlate, increased cortical thickness, of cross-modal plasticity. PMID:26885405

  1. In vitro evidence in rainbow trout supporting glucosensing mediated by sweet taste receptor, LXR, and mitochondrial activity in Brockmann bodies, and sweet taste receptor in liver.

    Science.gov (United States)

    Otero-Rodiño, Cristina; Velasco, Cristina; Álvarez-Otero, Rosa; López-Patiño, Marcos A; Míguez, Jesús M; Soengas, José L

    2016-10-01

    We previously obtained evidence in rainbow trout peripheral tissues such as liver and Brockmann bodies (BB) for the presence and response to changes in circulating levels of glucose (induced by intraperitoneal hypoglycaemic and hyperglycaemic treatments) of glucosensing mechanisms others than that mediated by glucokinase (GK). There were based on mitochondrial production of reactive oxygen species (ROS) leading to increased expression of uncoupling protein 2 (UCP2), and sweet taste receptor in liver and BB, and on liver X receptor (LXR) and sodium/glucose co-transporter 1 (SGLT-1) in BB. We aimed in the present study to obtain further in vitro evidence for the presence and functioning of these systems. In a first experiment, pools of sliced liver and BB were incubated for 6h at 15°C in modified Hanks' medium containing 2, 4, or 8mM d-glucose, and we assessed the response of parameters related to these glucosensing mechanisms. In a second experiment, pools of sliced liver and BB were incubated for 6h at 15°C in modified Hanks' medium with 8mM d-glucose alone (control) or containing 1mM phloridzin (SGLT-1 antagonist), 20μM genipin (UCP2 inhibitor), 1μM trolox (ROS scavenger), 100μM bezafibrate (T1R3 inhibitor), and 50μM geranyl-geranyl pyrophosphate (LXR inhibitor). The results obtained in both experiments support the presence and functioning of glucosensor mechanisms in liver based on sweet taste receptor whereas in BB the evidence support those based on LXR, mitochondrial activity and sweet taste receptor. PMID:27139261

  2. Decision boxes for clinicians to support evidence-based practice and shared decision making: the user experience

    Directory of Open Access Journals (Sweden)

    Giguere Anik

    2012-08-01

    -making process were added with the intent of clarifying the tool’s purpose. Information about the risks and benefits according to risk levels was added to the Decision Boxes, to try to ease the adaptation of the information to individual patients. Conclusion Results will guide the development of the eight remaining Decision Boxes. A future study will evaluate the effect of Decision Boxes on the integration of evidence-based and shared decision making principles in clinical practice.

  3. Jellyfish support high energy intake of leatherback sea turtles (Dermochelys coriacea: video evidence from animal-borne cameras.

    Directory of Open Access Journals (Sweden)

    Susan G Heaslip

    Full Text Available The endangered leatherback turtle is a large, highly migratory marine predator that inexplicably relies upon a diet of low-energy gelatinous zooplankton. The location of these prey may be predictable at large oceanographic scales, given that leatherback turtles perform long distance migrations (1000s of km from nesting beaches to high latitude foraging grounds. However, little is known about the profitability of this migration and foraging strategy. We used GPS location data and video from animal-borne cameras to examine how prey characteristics (i.e., prey size, prey type, prey encounter rate correlate with the daytime foraging behavior of leatherbacks (n = 19 in shelf waters off Cape Breton Island, NS, Canada, during August and September. Video was recorded continuously, averaged 1:53 h per turtle (range 0:08-3:38 h, and documented a total of 601 prey captures. Lion's mane jellyfish (Cyanea capillata was the dominant prey (83-100%, but moon jellyfish (Aurelia aurita were also consumed. Turtles approached and attacked most jellyfish within the camera's field of view and appeared to consume prey completely. There was no significant relationship between encounter rate and dive duration (p = 0.74, linear mixed-effects models. Handling time increased with prey size regardless of prey species (p = 0.0001. Estimates of energy intake averaged 66,018 kJ • d(-1 but were as high as 167,797 kJ • d(-1 corresponding to turtles consuming an average of 330 kg wet mass • d(-1 (up to 840 kg • d(-1 or approximately 261 (up to 664 jellyfish • d(-1. Assuming our turtles averaged 455 kg body mass, they consumed an average of 73% of their body mass • d(-1 equating to an average energy intake of 3-7 times their daily metabolic requirements, depending on estimates used. This study provides evidence that feeding tactics used by leatherbacks in Atlantic Canadian waters are highly profitable and our results are consistent with estimates of mass gain prior to

  4. Jellyfish support high energy intake of leatherback sea turtles (Dermochelys coriacea): video evidence from animal-borne cameras.

    Science.gov (United States)

    Heaslip, Susan G; Iverson, Sara J; Bowen, W Don; James, Michael C

    2012-01-01

    The endangered leatherback turtle is a large, highly migratory marine predator that inexplicably relies upon a diet of low-energy gelatinous zooplankton. The location of these prey may be predictable at large oceanographic scales, given that leatherback turtles perform long distance migrations (1000s of km) from nesting beaches to high latitude foraging grounds. However, little is known about the profitability of this migration and foraging strategy. We used GPS location data and video from animal-borne cameras to examine how prey characteristics (i.e., prey size, prey type, prey encounter rate) correlate with the daytime foraging behavior of leatherbacks (n = 19) in shelf waters off Cape Breton Island, NS, Canada, during August and September. Video was recorded continuously, averaged 1:53 h per turtle (range 0:08-3:38 h), and documented a total of 601 prey captures. Lion's mane jellyfish (Cyanea capillata) was the dominant prey (83-100%), but moon jellyfish (Aurelia aurita) were also consumed. Turtles approached and attacked most jellyfish within the camera's field of view and appeared to consume prey completely. There was no significant relationship between encounter rate and dive duration (p = 0.74, linear mixed-effects models). Handling time increased with prey size regardless of prey species (p = 0.0001). Estimates of energy intake averaged 66,018 kJ • d(-1) but were as high as 167,797 kJ • d(-1) corresponding to turtles consuming an average of 330 kg wet mass • d(-1) (up to 840 kg • d(-1)) or approximately 261 (up to 664) jellyfish • d(-1). Assuming our turtles averaged 455 kg body mass, they consumed an average of 73% of their body mass • d(-1) equating to an average energy intake of 3-7 times their daily metabolic requirements, depending on estimates used. This study provides evidence that feeding tactics used by leatherbacks in Atlantic Canadian waters are highly profitable and our results are consistent with estimates of mass gain prior to

  5. Administrating Solr

    CERN Document Server

    Mohan, Surendra

    2013-01-01

    A fast-paced, example-based guide to learning how to administrate, monitor, and optimize Apache Solr.""Administrating Solr"" is for developers and Solr administrators who have a basic knowledge of Solr and who are looking for ways to keep their Solr server healthy and well maintained. A basic working knowledge of Apache Lucene is recommended, but this is not mandatory.

  6. Administrative Synergy

    Science.gov (United States)

    Hewitt, Kimberly Kappler; Weckstein, Daniel K.

    2012-01-01

    One of the biggest obstacles to overcome in creating and sustaining an administrative professional learning community (PLC) is time. Administrators are constantly deluged by the tyranny of the urgent. It is a Herculean task to carve out time for PLCs, but it is imperative to do so. In this article, the authors describe how an administrative PLC…

  7. American Recovery and Reinvestment Act (ARRA) - FEMP Technical Assistance - Federal Aviation Administration - Project 209 - Control Tower and Support Building, Boise, Idaho

    Energy Technology Data Exchange (ETDEWEB)

    Arends, J.; Sandusky, William F.

    2010-06-28

    This report documents an energy audit performed by Pacific Northwest National Laboratory (PNNL) and Redhorse Corporation (Redhorse) conducted on the Federal Aviation Administration (FAA) control tower and base building in Boise, Idaho. This report presents findings of the energy audit team that evaluated construction documents and operating specifications (at the 100% level) followed by a site visit of the facility under construction. The focus of the review was to identify measures that could be incorporated into the final design and operating specifications that would result in additional energy savings for FAA that would not have otherwise occurred.

  8. Administrative Circulars

    CERN Multimedia

    Département des Ressources humaines

    2004-01-01

    Administrative Circular N° 2 (Rev. 2) - May 2004 Guidelines and procedures concerning recruitment and probation period of staff members This circular has been revised. It cancels and replaces Administrative Circular N° 2 (Rev. 1) - March 2000. Administrative Circular N° 9 (Rev. 3) - May 2004 Staff members contracts This circular has been revised. It cancels and replaces Administrative Circular N° 9 (Rev. 2) - March 2000. Administrative Circular N° 26 (Rev. 4) - May 2004 Procedure governing the career evolution of staff members This circular has also been revised. It Administrative Circulars Administrative Circular N° 26 (Rev. 3) - December 2001 and brings up to date the French version (Rev. 4) published on the HR Department Web site in January 2004. Operational Circular N° 7 - May 2004 Work from home This circular has been drawn up. Operational Circular N° 8 - May 2004 Dealing with alcohol-related problems...

  9. Confirmation of linkage of Hypokalemic periodic paralysis to chromosome 1q31-32: Further evidence supporting CACNL1A3 as a candidate gene

    Energy Technology Data Exchange (ETDEWEB)

    Lewis, K.; Knouff, C.; Gaskell, P.C. [Duke Univ. Medical Center, Durham, NC (United States)] [and others

    1994-09-01

    Hypokalemic periodic paralysis (HOKPP; MIM 170400) is one entity of a series of periodic paralyses characterized by episodic bouts of weakness with onset in the second to third decades. The hypokalemic form is defined by decreased serum potassium during a paralytic attack. HOKPP can occur in both familial and sporadic forms; the familal form is autosomal dominant with reduced penetrance in female gene carriers. Recently, Fontaine et al. have localized HOKPP to 1q31-32 in three multigenerational HOKPP families. The region of sub-localization includes the CACNL1A3 gene, making it a potential candidate for the genetic defect in HOKPP. We have ascertained and sampled 2 large multigenerational HOKPP pedigrees (N = 55 individuals with DNA) for linkage analysis. The families were initially screened for linkage with over 150 marker loci located throughout the genome. Analysis of the chromosome 1 markers D1S412, D1S413 and F13B gave significant evidence for linkage. The peak two-point lod score realized was Z = 4.34 at theta = 0.0 (D1S413). A sex-dependent penetrance of 80% was assumed, although varying the penetrance did not significantly alter the results. There was no evidence for heterogeneity. Multipoint analysis of the data defined the region between D1S238 and D1S245 (which contains the CACNL1A3 gene) as the most likely region (> 1000 odds) for the location of the HOKPP gene. There were no obligate recombinants among males or affected females for the CACNL1A3 (Z = 3.19, theta = 0.0), although several potential non-penetrant females were identified. These studies confirm linkage of HOPKK to chromosome 1 in an independent data set, lend further support of CACNL1A3 as a potential candidate gene, and give evidence for homogeneity in this disease.

  10. Administrative Reform

    DEFF Research Database (Denmark)

    Plum, Maja

    Through the example of a Danish reform of educational plans in early childhood education, the paper critically addresses administrative educational reforms promoting accountability, visibility and documentation. Drawing on Foucaultian perspectives, the relation between knowledge and governing...... administrative technology, tracing how the humanistic values of education embed and are embedded within ‘the professional nursery teacher' as an object and subject of administrative practice. Rather than undermining the humanistic potential of education, it is argued that the technology of accounting, in this...

  11. Biodistribution of rAAV vectors following intraocular administration: evidence for the presence and persistence of vector DNA in the optic nerve and in the brain.

    Science.gov (United States)

    Provost, Nathalie; Le Meur, Guylène; Weber, Michel; Mendes-Madeira, Alexandra; Podevin, Guillaume; Cherel, Yan; Colle, Marie-Anne; Deschamps, Jack-Yves; Moullier, Philippe; Rolling, Fabienne

    2005-02-01

    The purpose of our study was to evaluate the biodistribution of rAAV vectors following subretinal or intravitreal injection. In rats, we performed subretinal or intravitreal injections of rAAV-2/2.CMV.gfp. In large animals, rAAV-2/4.CMV.gfp or rAAV-2/5.CMV.gfp was delivered into the subretinal space while rAAV-2/2.CMV.gfp was delivered either to the subretinal space or to the vitreous. In euthanized animals, we undertook a complete necropsy. In animals maintained alive, we collected blood and tissue samples from the submandibular lymph node, liver, and gonads. We analyzed total DNA, extracted from various tissue samples and peripheral blood mononuclear cells (PBMC), by PCR. Following subretinal or intravitreal injections in rats and in large animals, vector sequences were not detected in the liver or in the gonads but were occasionally found in PBMC. An unexpected result was the detection of rAAV sequences in the optic nerve following subretinal injection. The most striking finding was the detection of vector sequences in the brain, along the visual pathway, in rAAV-2/2 intravitreally injected dogs. These findings raise safety concerns regarding intraocular administration of rAAV vectors and will have an impact on the development of future gene therapy trials for retinal diseases. PMID:15668139

  12. Is tattooing a risk factor for adolescents' criminal behavior? Empirical evidence from an administrative data set of juvenile detainees in Taiwan.

    Science.gov (United States)

    Liao, Pei-An; Chang, Hung-Hao; Su, Yi-Ju

    2014-12-01

    Juvenile crime affects not only the victims of the crime but also the delinquents' future. How to prevent adolescent criminal behavior has become an important public policy issue. This study contributes to this interesting issue by examining the relationship between tattooing and adolescents' criminal behavior. In particular, this study investigates whether or not having a tattoo/tattoos is connected to the incidence of various criminal activities, including: larceny, robbery, fraud, assault, drug use, and homicide. A unique sample of 973 juvenile detainees drawn from the administrative profiles in Taiwan and the coarsened exact matching method were utilized. Results show that compared to their nontattooed counterparts, tattooed juvenile detainees were significantly more likely to commit fraud, assault, drug abuse, and homicide by 3%, 13%, 9%, and 9%, respectively. In contrast, tattooing was not significantly associated with larceny or robbery. From a policy perspective, given the significant link between tattooing and criminal behavior, the presence of a tattoo in adolescents may serve as a valuable indicator regarding adolescents' high probability of committing crimes. PMID:25598482

  13. Learning Cassandra for administrators

    CERN Document Server

    Parthasarathy, Vijay

    2013-01-01

    This book is a practical, hands-on guide, taking the reader from the basics of using Cassandra though to the installation and the running.Learning Cassandra for Administrators is for administrators who manage a large deployment of Cassandra clusters, and support engineers who would like to install the monitoring tools and who are also in charge of making sure the cluster stays the same, ensuring that the service is always up and running.

  14. Administrative Ecology

    Science.gov (United States)

    McGarity, Augustus C., III; Maulding, Wanda

    2007-01-01

    This article discusses how all four facets of administrative ecology help dispel the claims about the "impossibility" of the superintendency. These are personal ecology, professional ecology, organizational ecology, and community ecology. Using today's superintendency as an administrative platform, current literature describes a preponderance of…

  15. Relationship between hierarchic - spatial differentiation of social structure and population size of municipalities in turkey: Evidence from the election case of local administration in 2004

    Directory of Open Access Journals (Sweden)

    Murat Çiftçi

    2011-07-01

    Full Text Available Turkey, whose population is young and dynamic, is a country where social change has a high acceleration. This circumstance has led to a spatial heterogeneity of social structure in the scale of campuses. Almost all the municipalities differ significantly from each other. In results of statistical applications, it was possible to conclude that there is a relationship between spatial differentiation of social structure indicators (PDI, PIDI and population sizes in municipalities. This relationship also supports that there was a differentiation of graded spatial social structure among municipalities in the Turkey of 2004. It is possible to make contact with this to the spatial differentiation that moves in parallel with population size and is in transition degree from a community to a society.

  16. Does mass drug administration for the integrated treatment of neglected tropical diseases really work? Assessing evidence for the control of schistosomiasis and soil-transmitted helminths in Uganda

    Directory of Open Access Journals (Sweden)

    Allen Tim

    2011-01-01

    Full Text Available Abstract Background Less is known about mass drug administration [MDA] for neglected tropical diseases [NTDs] than is suggested by those so vigorously promoting expansion of the approach. This paper fills an important gap: it draws upon local level research to examine the roll out of treatment for two NTDs, schistosomiasis and soil-transmitted helminths, in Uganda. Methods Ethnographic research was undertaken over a period of four years between 2005-2009 in north-west and south-east Uganda. In addition to participant observation, survey data recording self-reported take-up of drugs for schistosomiasis, soil-transmitted helminths and, where relevant, lymphatic filariasis and onchocerciasis was collected from a random sample of at least 10% of households at study locations. Data recording the take-up of drugs in Ministry of Health registers for NTDs were analysed in the light of these ethnographic and social survey data. Results The comparative analysis of the take-up of drugs among adults revealed that although most long term residents have been offered treatment at least once since 2004, the actual take up of drugs for schistosomiasis and soil-transmitted helminths varies considerably from one district to another and often also within districts. The specific reasons why MDA succeeds in some locations and falters in others relates to local dynamics. Issues such as population movement across borders, changing food supply, relations between drug distributors and targeted groups, rumours and conspiracy theories about the 'real' purpose of treatment, subjective experiences of side effects from treatment, alternative understandings of affliction, responses to social control measures and historical experiences of public health control measures, can all make a huge difference. The paper highlights the need to adapt MDA to local circumstances. It also points to specific generalisable issues, notably with respect to health education, drug distribution and

  17. Administrative Reform

    OpenAIRE

    Beh, LooSee

    2007-01-01

    This paper seeks to develop an understanding of the issues that public administrators should strive to provide in ethical practices and governance thus allowing distinctive administrative and social traditions that each country possess to flourish. Significant changes and continuities in the realm of government in contemporary China and Malaysia will be drawn upon. Recent developments have brought a sense of urgency in contrast to complacency with the status quo. This paper reviews pertinent ...

  18. Offentlig administration

    DEFF Research Database (Denmark)

    Nielsen, Elof Nellemann; Rehr, Preben René

    En undervisningsbog der henvender sig til administrationsbacheloruddannelsen. Kapitlerne er inddelt efter modulerne på uddannelsen og indeholder derfor elementer af administration, forvaltning, økonomistyring, innovation, samfundsvidenskabelige metoder og politisk styrede organisationer.......En undervisningsbog der henvender sig til administrationsbacheloruddannelsen. Kapitlerne er inddelt efter modulerne på uddannelsen og indeholder derfor elementer af administration, forvaltning, økonomistyring, innovation, samfundsvidenskabelige metoder og politisk styrede organisationer....

  19. A preliminary study in ward administration guided by evidence-based nursing%循证护理学指导的病房管理工作初探

    Institute of Scientific and Technical Information of China (English)

    周叶英; 徐冬梅; 温士玲

    2010-01-01

    To explore the method and result of ward administration guided by evidence-based nursing. On the net of China National Knowledge Infrastructure, the useful data about nursing errors were retrieved, then arrange in order of treating them and put emphasis on the clinical pharmacological managing. One year later, the nursing error amounts were compared. Of the reference documentations between January 2006 to December 2007,2 181 clinical nursing errors covered 10 years periods, of them referring drug using occupied 81.2%. The others were managed order 11.0% , nursing record 5. 2% and nursing handle 2. 5%. Administrating the ward according to the new management model the nursing errors reduced from around 18 to 5 comparing the former years. Due to evidence-based nursing guidance, the ward administration becomes systematic and orderly and the nursing errors going down apparently.%探讨循证护理学指导的病房管理工作方法和效果.在中国医院知识库网站搜集有关护理差错的文献,分类整理后找出病房管理的重点,实施改进措施后与往年的差错数量比较.在2006~2007年的文献中搜集到10年间发生的2 181件临床护理差错,与药物使用有关的差错占81.2%,其他依次为医嘱处理11.0%、护理记录5.2%、护理处置2.5%.按新模式进行病房管理后,1年内的差错由17~18件减少到5件.在循证护理学指导下,病房管理工作重点突出,有条不紊,护理差错明显下降.

  20. Understanding land administration systems

    DEFF Research Database (Denmark)

    P. Williamson, Ian; Enemark, Stig; Wallace, Judy;

    2008-01-01

    This paper introduces basic land administration theory and highlights four key concepts that are fundamental to understanding modern land administration systems - firstly the land management paradigm and its influence on the land administration framework, secondly the role that the cadastre plays...... in contributing to sustainable development, thirdly the changing nature of ownership and the role of land markets, and lastly a land management vision that promotes land administration in support of sustainable development and spatial enablement of society. We present here the first part of the paper. The second...... part focuses on the changing  role of ownership and the role of land markets, and a land management vision will be published in November issue of Coordinates. Udgivelsesdato: Oktober...

  1. A pragmatic study exploring the prevention of delirium among hospitalized older hip fracture patients: Applying evidence to routine clinical practice using clinical decision support

    Directory of Open Access Journals (Sweden)

    Schmaltz Heidi N

    2010-10-01

    Full Text Available Abstract Delirium occurs in up to 65% of older hip fracture patients. Developing delirium in hospital has been associated with a variety of adverse outcomes. Trials have shown that multi-component preventive interventions can lower delirium rates. The objective of this study was to implement and evaluate the effectiveness of an evidence-based electronic care pathway, which incorporates multi-component delirium strategies, among older hip fracture patients. We conducted a pragmatic study using an interrupted time series design in order to evaluate the use and impact of the intervention. The target population was all consenting patients aged 65 years or older admitted with an acute hip fracture to the orthopedic units at two Calgary, Alberta hospitals. The primary outcome was delirium rates. Secondary outcomes included length of hospital stay, in-hospital falls, in-hospital mortality, new discharges to long-term care, and readmissions. A Durbin Watson test was conducted to test for serial correlation and, because no correlation was found, Chi-square statistics, Wilcoxon test and logistic regression analyses were conducted as appropriate. At study completion, focus groups were conducted at each hospital to explore issues around the use of the order set. During the 40-week study period, 134 patients were enrolled. The intervention had no effect on the overall delirium rate (33% pre versus 31% post; p = 0.84. However, there was a significant interaction between study phase and hospital (p = 0.03. Although one hospital did not experience a decline in delirium rate, the delirium rate at the other hospital declined from 42% to 19% (p = 0.08. This difference by hospital was mirrored in focus group feedback. The hospital that experienced a decline in delirium rates was more supportive of the intervention. Overall, post-intervention there were no significant differences in mean length of stay (12 days post versus 14 days pre; p = 0.74, falls (6% post

  2. The carcinogenic action of crystalline silica: a review of the evidence supporting secondary inflammation-driven genotoxicity as a principal mechanism.

    Science.gov (United States)

    Borm, Paul J A; Tran, Lang; Donaldson, Ken

    2011-10-01

    In 1987 the International Agency for Research on Cancer (IARC) classified crystalline silica (CS) as a probable carcinogen and in 1997 reclassified it as a Group 1 carcinogen, i.e., that there was sufficient evidence for carcinogenicity in experimental animals and sufficient evidence for carcinogenicity in humans. The Working Group noted that "carcinogenicity in humans was not detected in all industrial circumstances studied, carcinogenicity may be dependent on inherent characteristics of the crystalline silica or on external factors affecting its biological activity or distribution of its polymorphs." This unusual statement that the physicochemical form of the CS influences its carcinogenicity is well understood at the toxicological level and arises as a consequence of the fact that CS activity depends on the reactivity of the CS surface, which can be blocked by a number of agents. We reviewed the literature on CS genotoxicity that has been published since the 1997 monograph, with special reference to the mechanism of CS genotoxicity. The mechanism of CS genotoxicity can be primary, a result of direct interaction of CS with target cells, or indirect, as a consequence of inflammation elicited by quartz, where the inflammatory cell-derived oxidants cause the genotoxicity. The review revealed a number of papers supporting the hypothesis that the CS genotoxic and inflammatory hazard is a variable one. In an attempt to attain a quantitative basis for the potential mechanism, we carried out analysis of published data and noted a 5-fold greater dose required to reach a threshold for genotoxic effects than for proinflammatory effects in the same cell line in vitro. When we related the calculated threshold dose at the proximal alveolar region for inflammation in a published study with the threshold dose for genotoxicity in vitro, we noted that a 60-120-fold greater dose was required for direct genotoxic effects in vitro. These data strongly suggests that inflammation is

  3. ADMINISTRATIVE CLIMATE.

    Science.gov (United States)

    BRUCE, ROBERT L.; CARTER, G.L., JR.

    IN THE COOPERATIVE EXTENSION SERVICE, STYLES OF LEADERSHIP PROFOUNDLY AFFECT THE QUALITY OF THE SERVICE RENDERED. ACCORDINGLY, MAJOR INFLUENCES ON ADMINISTRATIVE CLIMATE AND EMPLOYEE PRODUCTIVITY ARE EXAMINED IN ESSAYS ON (1) SOURCES OF JOB SATISFACTION AND DISSATISFACTION, (2) MOTIVATIONAL THEORIES BASED ON JOB-RELATED SATISFACTIONS AND NEEDS,…

  4. Database Administrator

    Science.gov (United States)

    Moore, Pam

    2010-01-01

    The Internet and electronic commerce (e-commerce) generate lots of data. Data must be stored, organized, and managed. Database administrators, or DBAs, work with database software to find ways to do this. They identify user needs, set up computer databases, and test systems. They ensure that systems perform as they should and add people to the…

  5. Bayesian integrated testing strategy (ITS) for skin sensitization potency assessment: a decision support system for quantitative weight of evidence and adaptive testing strategy.

    Science.gov (United States)

    Jaworska, Joanna S; Natsch, Andreas; Ryan, Cindy; Strickland, Judy; Ashikaga, Takao; Miyazawa, Masaaki

    2015-12-01

    The presented Bayesian network Integrated Testing Strategy (ITS-3) for skin sensitization potency assessment is a decision support system for a risk assessor that provides quantitative weight of evidence, leading to a mechanistically interpretable potency hypothesis, and formulates adaptive testing strategy for a chemical. The system was constructed with an aim to improve precision and accuracy for predicting LLNA potency beyond ITS-2 (Jaworska et al., J Appl Toxicol 33(11):1353-1364, 2013) by improving representation of chemistry and biology. Among novel elements are corrections for bioavailability both in vivo and in vitro as well as consideration of the individual assays' applicability domains in the prediction process. In ITS-3 structure, three validated alternative assays, DPRA, KeratinoSens and h-CLAT, represent first three key events of the adverse outcome pathway for skin sensitization. The skin sensitization potency prediction is provided as a probability distribution over four potency classes. The probability distribution is converted to Bayes factors to: 1) remove prediction bias introduced by the training set potency distribution and 2) express uncertainty in a quantitative manner, allowing transparent and consistent criteria to accept a prediction. The novel ITS-3 database includes 207 chemicals with a full set of in vivo and in vitro data. The accuracy for predicting LLNA outcomes on the external test set (n = 60) was as follows: hazard (two classes)-100 %, GHS potency classification (three classes)-96 %, potency (four classes)-89 %. This work demonstrates that skin sensitization potency prediction based on data from three key events, and often less, is possible, reliable over broad chemical classes and ready for practical applications. PMID:26612363

  6. System Administration Support/SWORDS G2

    Science.gov (United States)

    Dito, Scott Joseph

    2014-01-01

    The Soldier-Warfighter Operationally Responsive Deployer for Space (SWORDS) rocket is a dedicated small satellite launcher that will minimize danger and complexity in order to allow soldiers in the field to put payloads of up to 25kg into orbit from the field. The SWORDSG2 project is the development of a model, simulation, and ultimately a working application that will control and monitor the cryogenic fluid delivery to the SWORDS rocket for testing purposes. To accomplish this, the project is using the programming language environment Gensym G2. The environment is an all-inclusive application that allows development, testing, modeling, and finally operation of the unique application through graphical and programmatic methods. In addition, observation of the current cryogenic fluid delivery system in the Kennedy Space Center Cry Lab has allowed me to gain valuable experience of fluid systems and propelant delivery that is valuable to our team when developing amd modeling our own system.The ultimate goal of having a test-ready application to show to the heads of the project, and demonstrating G2's capabilities, by late 2014 will require hard work and intense study and understanding of not only the programming aspect but also the physical phenomena we want to model, observe, and control.

  7. The Direct Influence of the Support on the Electronic Structure of the Active Sites in Supported Metal Catalysts : Evidence from Pt-H Anti-Bonding Shape Resonance and Pt-CO FTIR Data

    NARCIS (Netherlands)

    Koningsberger, D.C.; Ramaker, D.E.; Miller, J.T.; Graaf, J. de; Mojet, B.L.

    2001-01-01

    The catalytic activity and spectroscopic properties of supported noble metal catalysts are strongly influenced by support properties such as the presence of protons, type of charge compensating cations, Si/Al ratio and/or presence of extra-framework Al. The metal support interaction is relatively in

  8. Administration for Defence Scientists

    Directory of Open Access Journals (Sweden)

    G. E. Gale

    1953-01-01

    Full Text Available All scientific work must be carried out against a background of adequate administrative support if it is to become effective and produce useful results. Administration is not a job for which we, as scientists, are particularly trained; and it is a thing of which we tend to fight shy, partly because, author suppose, most Of peoples are associate the administrator with highly unpleasant matters such as income tax, delays in getting our pay cheques, and so on - For that reason we do not feel, always pay  sufficient attention to administrative affairs ; rather like the ostrich, we try to escape from them by merely ignoring them. But that is a wrong and unfruitful attitude to adopt. All live so much under the activities of the trained administrator that should, if, it  give a great deal of thought to our own administrative problems deliberate and conscious thought to them-and make an honest and heart-searching self analysis regarding our own possible failings.

  9. Care for the person, protection of health and respect for the will of the patient in Italy: support administration as a tool to jointly promote health and respect for autonomy in incompetent patients

    Directory of Open Access Journals (Sweden)

    Paola Delbon

    2014-12-01

    Full Text Available In Italy, advance health care directives are a subject of considerable debate in both legal theory and practice. This debate focuses in partic- ular not only on the appropriateness of approving ad hoc statutory reg- ulations but also on the extent to which similar advance indications of a person’s wishes are applicable under the existing legal system, albeit in the absence of a law regulating them. The authors of this paper con- sider, in particular, guidelines relating to the possible use of the mech- anism of support administration (amministrazione di sostegno (Law No. 6/2004 as a procedure to be used for the legal recognition of advance health care directives, particularly in the light of the legal pro- vision for the possible designation in advance of a support administra- tor by a beneficiary in anticipation of an eventual situation of incapac- ity. This underlines how the concept of health does not only exist in the abstract, but must be measured in relation to the particular patient in the particular situation and how beneficence and respect for auton- omy are both essential elements in the choices aimed at promoting the health and the wellbeing of its citizens.

  10. Supporting human resources in educational institutions: Teacher views on administrator supportEğitim kurumlarında insan kaynaklarının desteklenmesi: Yönetici desteğine yönelik öğretmen görüşleri

    Directory of Open Access Journals (Sweden)

    Türkan Argon

    2014-09-01

    Full Text Available Current research examined administrator support based on teacher views in primary schools. Case study model, a qualitative research design, was used. Working group, identified according to convenience sampling method, consisted of 51 teachers employed in Bolu primary schools.  Interview forms were used as data collection tools. According to results, supportive school administrators have positive personal characteristics, facilitate teachers’ personal and professional developments and provide motivation, ensure effective teaching environments and lead teachers by presenting a collaborative attitude through including staff in decision making. Teachers supported by administrators experience positive feelings in personal and professional terms and reflect these feelings behaviorally.  Factors preventing administrators from supporting teachers are personality and management characteristics, school practices, school-environment relationships and lack of financial means. While 30% of teachers believe administrators support teachers in Turkish Educational System, 21% state that administrators inhibit them. ÖzetBu araştırmanın amacı öğretmen görüşleri doğrultusunda ilkokullarda yönetici desteği konusunu incelemektir. Nitel araştırma deseni esas alınan araştırmada durum çalışması modeli benimsenmiştir. Kolay ulaşılabilir durum örneklemesine göre belirlenen araştırmanın çalışma grubunu Bolu merkez ilçe ilkokullarında görev yapan 51 öğretmen oluşturmaktadır. Veri toplama aracı olarak görüşme formu kullanılmıştır. Araştırmaya göre destekleyici okul yöneticisi; olumlu kişilik özelliklerine sahip, öğretmenlerin kişisel ve mesleki gelişimlerinde kolaylaştırıcı olup motive edebilen, eğitim öğretim ortamının etkili oluşturulmasını sağlayan, çalışanlarını alınan kararlara katarak işbirlikçi bir tutum sergileyerek liderlik yapan yöneticidir. Yöneticisi tarafından desteklenen

  11. Administrative decisions

    International Nuclear Information System (INIS)

    This article reviews relevant administrative decisions that have been taken in various countries during the last semester of 1999 and the first one of 2000. In Argentina, an inter-ministerial commission has been settled to examine the prospects of completing the construction of the Atucha-2 unit. In Sweden, an agreement has been signed between Sydkraft, Vattenfall and the Swedish government on a compensation plan for the early shutdown of the Barsebaeck unit 1. In Switzerland, the government of the canton of Bern has rejected a constitutional initiative requesting the shutdown of the Muehleberg nuclear power plant. (A.C.)

  12. Evidence from randomised controlled trials did not support the introduction of dietary fat guidelines in 1977 and 1983: a systematic review and meta-analysis

    OpenAIRE

    Harcombe, Zoë; Julien S Baker; Cooper, Stephen Mark; Davies, Bruce; Sculthorpe, Nicholas; DiNicolantonio, James J; Grace, Fergal

    2015-01-01

    Objectives National dietary guidelines were introduced in 1977 and 1983, by the US and UK governments, respectively, with the ambition of reducing coronary heart disease (CHD) by reducing fat intake. To date, no analysis of the evidence base for these recommendations has been undertaken. The present study examines the evidence from randomised controlled trials (RCTs) available to the US and UK regulatory committees at their respective points of implementation. Methods A systematic review and ...

  13. Administrative building

    OpenAIRE

    Vokatá, Kateřina

    2015-01-01

    The task of my master´s thesis was to work up a project and a check of a bearing steel construction the multi-storey office building with a garage in Brno. The building is composed of five storey office section and two storey of garage. Ground dimension of administrative part is 38,8m x 35m with distance of pillars 7m,6m and 6,4m. The structural height of floor is 3,5m.Garage is designed with dimensions 36m x 24,8m with structural height of floor 3,5m. Distance of pillars is 5,6m, 6,4m and 7,...

  14. ADMINISTRATIVE CIRCULARS

    CERN Multimedia

    Division des ressources humaines

    2000-01-01

    N° 2 (Rev. 1) - March 2000Guidelines and procedures concerning recruitment and probation period of staff membersN° 9 (Rev. 2) - March 2000Staff members contractsN° 16 (Rev. 2) - January 2000TrainingN° 30 (Rev. 1) - January 2000Indemnities and reimbursements upon taking up appointment and termination of contractN° 32 - February 2000Principles and procedures governing complaints of harassmentThese circular have been amended (No 2, N° 9, N° 16 and N° 30) or drawn up (N° 32).Copies are available in the Divisional Secretariats.Note:\tAdministrative and operational circulars, as well as the lists of those in force, are available for consultation in the server SRV4_Home in the Appletalk zone NOVELL (as GUEST or using your Novell username and password), volume PE Division Data Disk.The Word files are available in the folder COM, folder Public, folder ADM.CIRC.docHuman Resources DivisionTel. 74128

  15. The role of patch testing in the evaluation of orthopedic implant-related adverse effects: current evidence does not support broad use.

    Science.gov (United States)

    Crawford, Glen H

    2013-01-01

    In recent years, there has been a growing interest in the use of skin patch testing to evaluate patients for orthopedic, implant-related adverse effects. This may be done preoperatively to avoid implanting a material to which an individual may be allergic or postoperatively to implicate sensitivity as a cause for implant failure. There is emerging evidence that patch testing might have utility in the workup of implant-related adverse events; however, the level of evidence at the present time is weak and based only on a collection of case reports, series, and retrospective cohort studies (level IV evidence as per United States Department of Health and Human Services guidelines); there are no randomized controlled trials (level I evidence) with which to guide medical decision making. Recent reports have advocated that patch testing be broadly used in the preoperative evaluation of all patients self-reporting a history of metal sensitivity. In addition, several authors have advocated that patch test results should guide preoperative implant selection and postoperative implant removal. It is the opinion of this author that these recommendations are premature, lacking robust clinical evidence, and unfeasible given the broad-reaching logistical impact and societal costs involved. More robust clinical data are needed, and thorough cost-benefit analyses must be performed before such far-reaching and costly systematic practices should be broadly implemented. PMID:23665834

  16. Nutrition support in hospitals

    DEFF Research Database (Denmark)

    Kondrup, Jens

    2005-01-01

    Nutrition support in hospitals is becoming an area of focus because of the evidence showing improved clinical outcome with nutrition support, its status as a human rights issue and its integration into quality assurance.......Nutrition support in hospitals is becoming an area of focus because of the evidence showing improved clinical outcome with nutrition support, its status as a human rights issue and its integration into quality assurance....

  17. What does it take? How federal initiatives can support the implementation of evidence-based programs to improve outcomes for adolescents.

    Science.gov (United States)

    Metz, Allison; Albers, Bianca

    2014-03-01

    Over the last 20 years, there has been a growing emphasis on developing and identifying evidence-based programs and practices for children and families and within the last decade an increasing number of federally funded initiatives have been dedicated to replicating and scaling evidence-based programs with the hope of achieving socially meaningful impact. However, only recently have efforts to promote high-fidelity implementation been given the attention needed to ensure evidence-based practices are used as intended and generate the outcomes they were designed to produce. In this article, we propose that the wide-scale implementation of evidence-based practices requires: (1) careful assessment and selection of the "what"; (2) a stage-based approach that provides adequate time and resources for planning and installation activities; (3) the co-creation of a visible infrastructure by a triad of key stakeholders including funders and policymakers, program developers, and implementing sites; and (4) the use of data to guide decision-making and foster curiosity into continuous improvement among grantees. Each of these strategies is explored in greater detail through the lens of the Teen Pregnancy Prevention (TPP) Program, a $100 million initiative overseen by the Office of Adolescent Health (OAH) in the U.S. Department of Health and Human Services. PMID:24560083

  18. Women's Centers and Women Administrators: Breaking the Glass Slipper Together.

    Science.gov (United States)

    Mellow, Gail O.

    1988-01-01

    Focuses on benefits of mutually supportive relationships between female administrators and women's center directors. Identifies specific roles that female administrators can play (guardian angel, mentor). Also discusses benefits that administrators derive from closer ties with center directors. (NB)

  19. Terrorist threat and perceived Islamic support for terrorist attacks as predictors of personal and institutional out-group discrimination and support for anti-immigration policies: evidence from 9 European countries

    NARCIS (Netherlands)

    B. Doosje; A. Zimmermann; B. Küpper; A. Zick; R. Meertens

    2009-01-01

    Traditionally, research has shown that subtle and blatant prejudices are important predictors of out-group discrimination and support for anti-immigration policies. The present paper shows that, when controlling for these types of prejudices and for political conservatism, terrorist threat and perce

  20. ROLE OF HOSPITAL ADMINISTRATION

    OpenAIRE

    UDAYSINH R. MANEPATIL

    2013-01-01

    Hospital administration is the management of the hospital as a business. The administration is made up of medical and health services managers (sometimes called health care executives and health care administrators) and assistant administrators. Administrations range in size and the duties of the administrator depends on the size of the administration.

  1. Does Sufficient Evidence Exist to Support a Causal Association between Vitamin D Status and Cardiovascular Disease Risk? An Assessment Using Hill’s Criteria for Causality

    OpenAIRE

    Weyland, Patricia G.; Grant, William B; Jill Howie-Esquivel

    2014-01-01

    Serum 25-hydroxyvitamin D (25(OH)D) levels have been found to be inversely associated with both prevalent and incident cardiovascular disease (CVD) risk factors; dyslipidemia, hypertension and diabetes mellitus. This review looks for evidence of a causal association between low 25(OH)D levels and increased CVD risk. We evaluated journal articles in light of Hill’s criteria for causality in a biological system. The results of our assessment are as follows. Strength of association: many randomi...

  2. The rush to judgment: does the evidence support the enthusiasm over three-dimensional conformal radiation therapy and dose escalation in the treatment of prostate cancer?

    International Nuclear Information System (INIS)

    Purpose: To discuss the assumptions behind and current clinical evidence on three-dimensional conformal radiation therapy (3D-CRT) and dose escalation in the treatment of prostate cancer. Methods: We first define 3D-CRT in comparison to standard radiation therapy and discuss the assumptions on which the technology of 3D-CRT and dose escalation are based. We then examine the evidence on the benefits and limitations from the current most commonly cited studies on dose-escalation trials to treat prostate cancer. Results: The assumption that 3D-CRT can provide a tighter margin around the tumor area to allow for dose escalation is not yet proven by studies that show continual difficulty in defining the planning treatment volume because of extrinsic and intrinsic difficulties, such as imaging variabilities and patient and organ movement. Current short-term dose-escalation studies on the use of 3D-CRT to treat prostate cancer are limited in their ability to prove that increasing dose improves survival and does not incur potential long-term complications to normal tissue. Conclusion: Although 3D-CRT is a promising technology that many radiation oncologists and clinics are quickly adopting to treat such tumors as prostate cancer, the long-term evidence on the benefits and limitations of this technology is still lacking. Until we have solid long-term evidence on the true clinical potential of this new technology, let us not rush to judgment, but exercise caution, diligence, and thoughtfulness in using this new technology to treat our patients

  3. 7 CFR 652.3 - Administration.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Administration. 652.3 Section 652.3 Agriculture... AGRICULTURE SUPPORT ACTIVITIES TECHNICAL SERVICE PROVIDER ASSISTANCE General Provisions § 652.3 Administration... requirements of this part. (b) The Chief, NRCS, will direct and supervise the administration of the...

  4. Career Socialization of Women in School Administration.

    Science.gov (United States)

    Marshall, Catherine

    This paper describes research that attempted to discover and describe the socialization process in school administrative careers that support or hinder women's decision-making for a career in school administration. After a theoretical framework was set up, twenty-five successful women administrators were interviewed and the data were analyzed. One…

  5. Novel Approaches to Surfactant Administration

    OpenAIRE

    Samir Gupta; Donn, Steven M.

    2012-01-01

    Surfactant replacement therapy has been the mainstay of treatment for preterm infants with respiratory distress syndrome for more than twenty years. For the most part, surfactant is administered intratracheally, followed by mechanical ventilation. In recent years, the growing interest in noninvasive ventilation has led to novel approaches of administration. This paper will review these techniques and the associated clinical evidence.

  6. Perception of the Community Power Structure by the Public School Administrator as Related to His Effectiveness. A Dissertation.

    Science.gov (United States)

    Hobbs, Philip Jesse

    This thesis describes a study that sought to ascertain if evidence could be found to support the idea that a relationship exists between a school administrator's ability to perceive the community power structure and his effectiveness in fulfilling role expectations as judged by his employer. A major thesis underlying this research held that…

  7. Capacity Building in Land Administration

    DEFF Research Database (Denmark)

    Enemark, Stig; Williamson, I

    2004-01-01

    Capacity building increasingly seen as a key component of land administration projects in developing and countries in transition undertaken by the international development banks and individual country development assistance agencies. However, the capacity building concept is often used within a...... should be dealt with as capacity building projects in themselves.    The article introduces a conceptual analytical framework that provides some guidance when dealing with capacity building for land administration in support of a broader land policy agenda....

  8. Evidências sobre o suporte durante o trabalho de parto/parto: uma revisão da literatura Evidence on support during labor and delivery: a literature review

    Directory of Open Access Journals (Sweden)

    Odaléa Maria Brüggemann

    2005-10-01

    Full Text Available Os efeitos do suporte à mulher durante o trabalho de parto/parto por profissionais de saúde, mulheres leigas e doulas, sobre os resultados maternos e neonatais têm sido avaliados em vários ensaios clínicos randomizados, metanálises e revisões sistemáticas. Este artigo apresenta a revisão desses estudos, enfocando as principais características, o provedor de suporte, a simultaneidade na presença ou não do companheiro/familiares da parturiente durante o trabalho de parto e parto, e os resultados obtidos. Foram incluídos os estudos publicados entre os anos de 1980 e 2004, que contemplam explicitamente os aspectos avaliados. De maneira geral, os resultados do suporte são favoráveis, destacando-se redução da taxa de cesarianas, da analgesia/medicamentos para alívio da dor, da duração do trabalho de parto, da utilização de ocitocina e produzindo aumento na satisfação materna com a experiência vivida. Quando o provedor de suporte não é um profissional de saúde, os benefícios têm sido mais acentuados. Os estudos disponíveis não avaliam o acompanhante escolhido pela parturiente como um provedor de suporte, o que constitui lacuna de conhecimento a ser preenchida.The effects of support for women during labor and delivery provided by health professionals, lay women, and doulas on the maternal and neonatal outcomes have been evaluated through randomized clinical trials, meta-analyses, and systematic reviews. This article presents a review of these studies, focusing on the principal characteristics, support provider, simultaneous presence of the woman's spouse and/or family members during labor and delivery and the outcomes. The analysis included studies published from 1980 to 2004 which explicitly approached these aspects. In general, the results of such support were favorable, highlighting a reduction in the cesarean rate, analgesia/ medication for pain relief, duration of labor, and utilization of oxytocin and an increase in

  9. The Effect of Means-Tested Income Support for the Elderly on Pre-Retirement Saving: Evidence from the SSI Program in the U.S.

    OpenAIRE

    David Neumark; Elizabeth Powers

    1997-01-01

    We attempt to draw inferences about potential behavioral responses to means-tested" income support for the elderly by examining the effects on saving of the Supplemental Security" Income (SSI) program for the aged in the U.S. Part of the SSI program provides payments to the" poor elderly, thus operating as a means-tested public retirement program. The federal" government sets eligibility criteria and benefit levels for the federal component of the program but many states supplement federal SS...

  10. Administrative Appeals and ADR in Danish Administrative Law

    DEFF Research Database (Denmark)

    Conradsen, Inger Marie; Gøtze, Michael

    2014-01-01

    Administrative Appeals, review, administrative tribunals, ombudsman, alternative dispute resolution......Administrative Appeals, review, administrative tribunals, ombudsman, alternative dispute resolution...

  11. Experimental evidence supporting the insensitivity of cloud droplet formation to the mass accommodation coefficient for condensation of water vapor to liquid water

    Science.gov (United States)

    Langridge, Justin M.; Richardson, Mathews S.; Lack, Daniel A.; Murphy, Daniel M.

    2016-06-01

    The mass accommodation coefficient for uptake of water vapor to liquid water, αM, has been constrained using photoacoustic measurements of aqueous absorbing aerosol. Measurements performed over a range of relative humidities and pressures were compared to detailed model calculations treating coupled heat and mass transfer occurring during photoacoustic laser heating cycles. The strengths and weaknesses of this technique are very different to those for droplet growth/evaporation experiments that have typically been applied to these measurements, making this a useful complement to existing studies. Our measurements provide robust evidence that αM is greater than 0.1 for all humidities tested and greater than 0.3 for data obtained at relative humidities greater than 88% where the aerosol surface was most like pure water. These values of αM are above the threshold at which kinetic limitations are expected to impact the activation and growth of aerosol particles in warm cloud formation.

  12. Does Sufficient Evidence Exist to Support a Causal Association between Vitamin D Status and Cardiovascular Disease Risk? An Assessment Using Hill’s Criteria for Causality

    Directory of Open Access Journals (Sweden)

    Patricia G. Weyland

    2014-09-01

    Full Text Available Serum 25-hydroxyvitamin D (25(OHD levels have been found to be inversely associated with both prevalent and incident cardiovascular disease (CVD risk factors; dyslipidemia, hypertension and diabetes mellitus. This review looks for evidence of a causal association between low 25(OHD levels and increased CVD risk. We evaluated journal articles in light of Hill’s criteria for causality in a biological system. The results of our assessment are as follows. Strength of association: many randomized controlled trials (RCTs, prospective and cross-sectional studies found statistically significant inverse associations between 25(OHD levels and CVD risk factors. Consistency of observed association: most studies found statistically significant inverse associations between 25(OHD levels and CVD risk factors in various populations, locations and circumstances. Temporality of association: many RCTs and prospective studies found statistically significant inverse associations between 25(OHD levels and CVD risk factors. Biological gradient (dose-response curve: most studies assessing 25(OHD levels and CVD risk found an inverse association exhibiting a linear biological gradient. Plausibility of biology: several plausible cellular-level causative mechanisms and biological pathways may lead from a low 25(OHD level to increased risk for CVD with mediators, such as dyslipidemia, hypertension and diabetes mellitus. Experimental evidence: some well-designed RCTs found increased CVD risk factors with decreasing 25(OHD levels. Analogy: the association between serum 25(OHD levels and CVD risk is analogous to that between 25(OHD levels and the risk of overall cancer, periodontal disease, multiple sclerosis and breast cancer. Conclusion: all relevant Hill criteria for a causal association in a biological system are satisfied to indicate a low 25(OHD level as a CVD risk factor.

  13. Culture and Social Support

    Science.gov (United States)

    Kim, Heejung S.; Sherman, David K.; Taylor, Shelley E.

    2008-01-01

    Social support is one of the most effective means by which people can cope with stressful events. Yet little research has examined whether there are cultural differences in how people utilize their social support networks. A review of studies on culture and social support presents evidence that Asians and Asian Americans are more reluctant to…

  14. Semantic Web for Program Administration

    OpenAIRE

    Qurban A. Memon; Shakeel Khoja

    2010-01-01

    Typically, administrative systems involving information in an academic environment are disjoint, spread across various departments and support independent queries. The objectives in this work include investigation on integrating these independent systems to provide support to intelligent queries run on the integrated platform. A framework is proposed that enriches data in the legacy systems to provide a value-added semantic layer where annotation, query and reasoning can be carried out to sup...

  15. Ultrastructural localization of extracellular matrix proteins of the lymph node cortex: evidence supporting the reticular network as a pathway for lymphocyte migration

    Directory of Open Access Journals (Sweden)

    Sobocinski Gregg P

    2010-08-01

    Full Text Available Abstract Background The lymph node (LN is a crossroads of blood and lymphatic vessels allowing circulating lymphocytes to efficiently recognize foreign molecules displayed on antigen presenting cells. Increasing evidence indicates that after crossing high endothelial venules, lymphocytes migrate within the node along the reticular network (RN, a scaffold of fibers enwrapped by fibroblastic reticular cells (FRC. Light microscopy has shown that the RN contains specific extracellular matrix (ECM proteins, which are putative molecular "footholds" for migration, and are known ligands for lymphocyte integrin adhesion receptors. Results To investigate whether ECM proteins of the RN are present on the outer surface of the FRC and are thus accessible to migrating lymphocytes, ultrastructural immunohistochemical staining of cynomolgus monkey LN was performed using antibodies to human ECM proteins that were successfully employed at the light microscopic level. The fibrillar collagens I and III were observed primarily within the reticular network fibers themselves. In contrast, the matrix proteins laminin, fibronectin, collagen IV, and tenascin were observed within the reticular fibers and also on the outer membrane surface of the FRC. Conclusions These findings suggest a molecular basis for how the RN functions as a pathway for lymphocyte migration within the lymph node.

  16. THERE IS INFLUENCE IN DEVELOPMENT OF COMPANIES WHICH BUILT STOCK, WITH SUPPORT OF INVESTIMENT FUND PRIVATE EQUITY AND VENTURE CAPITAL? EVIDENCES OF ENTRANT COMPANIES AT BOVESPA

    Directory of Open Access Journals (Sweden)

    Caciano Gianechini

    2013-09-01

    Full Text Available This work seeks to identify the impact of the participation of Private Equity funds and Venture Capital (PE/VC, the performance of companies that owned the contribution prior to the opening of capital (IPO. In a more objective the present study seeks to investigate whether companies that opened capital, financed by PE/VC, have performed better than the other formerly the Brazilian stock market debut. The sample of work consists of 116 companies that made the initial public offering (IPO in the São Paulo Stock Exchange (BOVESPA in the period January 2004 to December 2009. First identified that 41 enterprises debuted at BOVESPA being financed by PE/VC funds. Furthermore, the results indicate that the influence of PE/VC funds tend to improve some indices of profitability and market of companies after the IPO. In summary, the evidence found lead to the conclusion that the organizations of private equity and venture capital influence positively the performance of investee companies.

  17. Senior Administrators Should Have Administrative Contracts.

    Science.gov (United States)

    Posner, Gary J.

    1987-01-01

    Recognizing that termination is viewed by the employee as the equivalent to capital punishment of a career, an administrative contract can reduce the emotional and financial entanglements that often result. Administrative contracts are described. (MLW)

  18. Administrator Career Paths and Decision Processes

    Science.gov (United States)

    Farley-Ripple, Elizabeth N.; Raffel, Jeffrey A.; Welch, Jennie Christine

    2012-01-01

    Purpose: The purpose of this paper is to present qualitative evidence on the processes and forces that shape school administrator career paths. Design/methodology/approach: An embedded case study approach is used to understand more than 100 administrator career transitions within the Delaware education system. Semi-structured interview data were…

  19. 38 CFR 9.7 - Administrative decisions.

    Science.gov (United States)

    2010-07-01

    ... 38 Pensions, Bonuses, and Veterans' Relief 1 2010-07-01 2010-07-01 false Administrative decisions... SERVICEMEMBERS' GROUP LIFE INSURANCE AND VETERANS' GROUP LIFE INSURANCE § 9.7 Administrative decisions. (a... essential to a decision in the matter. Based on the evidence obtained, a formal determination will be...

  20. Variation in the oxygen isotope ratio of phloem sap sucrose from castor bean. Evidence in support of the Péclet effect.

    Science.gov (United States)

    Barbour, M M; Schurr, U; Henry, B K; Wong, S C; Farquhar, G D

    2000-06-01

    Theory suggests that the level of enrichment of (18)O above source water in plant organic material (Delta) may provide an integrative indicator of control of water loss. However, there are still gaps in our understanding of the processes affecting Delta. One such gap is the observed discrepancy between modeled enrichment of water at the sites of evaporation within the leaf and measured enrichment of the leaf water as a whole (Delta(L)). Farquhar and Lloyd (1993) suggested that this may be caused by a Péclet effect. It is also unclear whether organic material formed in the leaf reflects enrichment of water at the sites of evaporation within the leaf or Delta(L). To investigate this question castor bean (Ricinus communis L.) leaves, still attached to the plant, were sealed into a controlled-environment gas exchange chamber and subjected to a step change in leaf-to-air vapor pressure difference. Sucrose was collected from a cut on the petiole of the leaf in the chamber under equilibrium conditions and every hour for 6 h after the change in leaf-to-air vapor pressure difference. Oxygen isotope composition of sucrose in the phloem sap (Delta(suc)) reflected modeled Delta(L). A model is presented describing Delta(suc) at isotopic steady state, and accounts for 96% of variation in measured Delta(suc). The data strongly support the Péclet effect theory. PMID:10859197

  1. Does Competitive Work Improve Quality of Life for Adults with Severe Mental Illness? Evidence from a Randomized Trial of Supported Employment.

    Science.gov (United States)

    Gold, Paul B; Macias, Cathaleene; Rodican, Charles F

    2016-04-01

    A randomized trial comparing a facility-based Clubhouse (N = 83) to a mobile Program of Assertive Community Treatment (PACT; N = 84) tested the widely held belief that competitive employment improves global quality of life for adults with severe mental illness. Random regression analyses showed that, over 24 months of study participation, competitively employed Clubhouse participants reported greater global quality of life improvement, particularly with the social and financial aspects of their lives, as well as greater self-esteem and service satisfaction, compared to competitively employed PACT participants. However, there was no overall association between global quality of life and competitive work, or work duration. Future research will determine whether these findings generalize to other certified Clubhouses or to other types of supported employment. Multi-site studies are needed to identify key mechanisms for quality of life improvement in certified Clubhouses, including the possibly essential role of Clubhouse employer consortiums for providing high-wage, socially integrated jobs. PMID:24504832

  2. Lateral displacement of silty clay under cement-fly ash-gravel pile-supported embankments:Analytical consideration and field evidence

    Institute of Scientific and Technical Information of China (English)

    张崇磊; 蒋关鲁; 刘先峰; 王智猛

    2015-01-01

    Based on back analysis of lateral displacements measured in situ by using the analytical solution, a useful method for estimating stress concentration ratio of geosynthetic-reinforced and pile-supported (GRPS) embankments was proposed. In order to validate the proposed method, a full-scale high-speed railway embankment (HSRE) with four instrumented subsections over medium compressibility silty clay was constructed in three stages. The soil profile, construction procedure and monitoring of settlements and lateral displacements of the four test sections were described. The field deformation analysis results show that 1) the combined reinforcement of CFG piles and geosynthetic layer perform well in terms of reducing lateral displacements;2) the development of lateral displacements lags behind the increase of fill load, which can be attributed to the vertical load transfer mechanism of the pile foundation;and 3) pile length has a dominant effect on the stress distribution proportion between piles and surrounding soils. The comparison between predicted and experimental results suggests that the proposed analytical solution and the back analysis-based method are capable of reasonably estimating the lateral deformation and the stress concentration ratio, respectively, if the appropriate soil elastic modulus is chosen.

  3. 5 CFR 185.126 - Evidence.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Evidence. 185.126 Section 185.126 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS PROGRAM FRAUD CIVIL REMEDIES § 185.126 Evidence. (a) The ALJ shall determine the admissibility of evidence. (b) Except as provided...

  4. 5 CFR 831.103 - Evidence.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Evidence. 831.103 Section 831.103...) RETIREMENT Administration and General Provisions § 831.103 Evidence. (a) Standard Form 2806 (Individual..., the department, agency, or OPM should request inferior or secondary evidence which is then admissible....

  5. Genetic evidence for prevalence of alloparental care in a socially monogamous biparental cichlid fish, Perissodus microlepis, from Lake Tanganyika supports the "selfish shepherd effect" hypothesis.

    Science.gov (United States)

    Lee, Hyuk Je; Heim, Valentin; Meyer, Axel

    2016-05-01

    Alloparental care - care for unrelated young - is rare in animals, and its ecological or evolutionary advantages or, alternative maladaptive nature, remain unclear. We investigate alloparental care in the socially monogamous cichlid fish Perissodus microlepis from Lake Tanganyika that exhibits bi-parental care. In a genetic parentage analysis, we discovered a surprisingly high percentage of alloparental care represented by brood mixing, extra-pair paternity and extra-pair maternity in all broods that we investigated. The percentage of nondescendant juveniles of other parents, i.e., brood mixing, ranged from 5% to 57% (mean = 28%). The distribution of genetic parentage also suggests that this socially monogamous species has, in fact, polygamous mating system. The prevalence of genetically mixed broods can be best explained by two, not mutually exclusive hypotheses on farming-out and fostering behaviors. In the majority of broods, the sizes of the parents' own (descendant) offspring were significantly larger than those of the adopted (nondescendant) juveniles, supporting the 'selfish shepherd effect' hypothesis, i.e., that foster parents preferentially accept unrelated "smaller or not larger" young since this would tend to lower the predation risks for their own larger offspring. There was also a tendency for larger parents particularly mothers, more so than smaller parents, to care predominantly for their own offspring. Larger parents might be better at defending against cuckoldry and having foreign young dumped into their broods through farming-out behavior. This result might argue for maladaptive effects of allopatric care for the foster parents that only larger and possibly more experienced pairs can guard against. It needs to be determined why, apparently, the ability to recognize one's own young has not evolved in this species. PMID:27217943

  6. Cigarette smoke induced genotoxicity and respiratory tract pathology: evidence to support reduced exposure time and animal numbers in tobacco product testing.

    Science.gov (United States)

    Dalrymple, Annette; Ordoñez, Patricia; Thorne, David; Walker, David; Camacho, Oscar M; Büttner, Ansgar; Dillon, Debbie; Meredith, Clive

    2016-06-01

    Many laboratories are working to develop in vitro models that will replace in vivo tests, but occasionally there remains a regulatory expectation of some in vivo testing. Historically, cigarettes have been tested in vivo for 90 days. Recently, methods to reduce and refine animal use have been explored. This study investigated the potential of reducing animal cigarette smoke (CS) exposure to 3 or 6 weeks, and the feasibility of separate lung lobes for histopathology or the Comet assay. Rats were exposed to sham air or CS (1 or 2 h) for 3 or 6 weeks. Respiratory tissues were processed for histopathological evaluation, and Alveolar type II cells (AEC II) isolated for the Comet assay. Blood was collected for Pig-a and micronucleus quantification. Histopathological analyses demonstrated exposure effects, which were generally dependent on CS dose (1 or 2 h, 5 days/week). Comet analysis identified that DNA damage increased in AEC II following 3 or 6 weeks CS exposure, and the level at 6 weeks was higher than 3 weeks. Pig-a mutation or micronucleus levels were not increased. In conclusion, this study showed that 3 weeks of CS exposure was sufficient to observe respiratory tract pathology and DNA damage in isolated AEC II. Differences between the 3 and 6 week data imply that DNA damage in the lung is cumulative. Reducing exposure time, plus analyzing separate lung lobes for DNA damage or histopathology, supports a strategy to reduce and refine animal use in tobacco product testing and is aligned to the 3Rs (replacement, reduction and refinement). PMID:27160659

  7. The Evidence Movement

    DEFF Research Database (Denmark)

    Hansen, Hanne Foss; Rieper, Olaf

    2009-01-01

    The evidence movement and the idea of systematic reviews, defined as summaries of the results of already existing evaluation and research projects, have gained considerable support in recent years as many international as well as national evidence-producing organizations have been established. This...... article analyses how the idea is practised in the areas of health, social welfare and education and shows that evidence-producing organizations work differently. Some subscribe to the hierarchy of evidence, others to a typology of evidence. The consequences of these variations are discussed....

  8. Beginning SQL Server 2008 Administration

    CERN Document Server

    Walters, R

    2009-01-01

    Beginning SQL Server 2008 Administration is essential for anyone wishing to learn about implementing and managing SQL Server 2008 database. From college students, to experienced database administrators from other platforms, to those already familiar with SQL Server and wanting to fill in some gaps of knowledge, this book will bring all readers up to speed on the enterprise platform Microsoft SQL Server 2008. * Clearly describes relational database concepts* Explains the SQL Server database engine and supporting tools* Shows various database maintenance scenarios What you'll learn* Understand c

  9. 40 CFR 164.131 - Review by Administrator.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Review by Administrator. 164.131... Administrator. (a) The Administrator will review applications subject to this subpart D and supporting data submitted by the applicant to determine whether reconsideration of the Administrator's prior cancellation...

  10. Organization/Administration.

    Science.gov (United States)

    Chaffee, Ellen Earle

    Patterns that emerged from reviewing 26 syllabi for courses on organization and administration in higher education are discussed, and six sample syllabi are presented. The syllabi focused more on organization than administration. Of the 26 syllabi, 19 dealt with organization and administration generally; 5 with administration in a specific…

  11. 临床信息学:从数据管理到循证医学支持%Clinical Informatics: from data management to evidence -based medicine support

    Institute of Scientific and Technical Information of China (English)

    郑西川

    2012-01-01

    The paper introduces the concept and research hotspots of clinical informatics, depicts its transformation from data management to evidence -based medicine support, points out that the technology strategy of clinical informatics construction should include standardized explanation of clinical data information, clinical data mining, clinical statistical analysis and application, computer information system interface simulation, information technology- translational research. Clinical informatics research would help evidence -based medical management and application directly.%介绍临床信息学的定义及研究重点,阐明临床信息学从数据管理到循证医学支持的研究转变。指出临床信息化建设的技术策略包括临床数据信息规范化表达、临床数据挖掘、临床统计分析及应用、计算机信息系统接口模拟、信息技术转化研究。临床信息学研究对循证医疗管理应用有直接帮助作用。

  12. ORGANIZATION OF PUBLIC ADMINISTRATION

    OpenAIRE

    Mrkša, Jožica

    2012-01-01

    In the thesis titled Organization of Public Administration I concentrated in the review of national and foreign literature. My decision for this topic is based on the personal interest and relevance of the topic in this particular period of time. The purpose of my work was to present the public administration in general, with focus in public administration of Slovenia. At first, the theoretical background of public administration is presented, with following topics addressed: public administr...

  13. Case of administrative dispute

    OpenAIRE

    Xhemazie Ibraimi

    2015-01-01

    The activity of administrative bodies includes big numbers of various acts and actions, through which the will of public administration is formed. The will of public administration bodies, expressed in administrative individual and normative acts, in administrative contracts and real acts, finds its reflection in the Constitution, laws and other provisions of legal character. All this activity is not inerrant and therefore, it is not uncontrollable. The supervision of executive activity is su...

  14. FRACTAL PROPERTY OF ADMINISTRATION

    OpenAIRE

    Zlatko Brnjas

    2014-01-01

    To understand the constant increase in administration, we need a new approach to the administration. For many years, the administration has intensified as a closed science, associated only with economics, law and political science. However, this approach did not bring anything good, because almost nothing in the administration has improved. Therefore, it is necessary to connect the administration with the natural sciences which give the best description of the world around us. Because of this...

  15. Case of administrative dispute

    Directory of Open Access Journals (Sweden)

    Xhemazie Ibraimi

    2015-11-01

    Full Text Available The activity of administrative bodies includes big numbers of various acts and actions, through which the will of public administration is formed. The will of public administration bodies, expressed in administrative individual and normative acts, in administrative contracts and real acts, finds its reflection in the Constitution, laws and other provisions of legal character. All this activity is not inerrant and therefore, it is not uncontrollable. The supervision of executive activity is subject to political control of administrative acts through authorities designated for this purpose, as well as internal control and the judicial control. The institution of judicial control of administrative acts and actions appears as very important and widely treated in the legal doctrine. The protection of constitutional and legal rights of private persons is accomplished by subjecting administrative activity both to internal administrative control, as well as to the judicial control in accordance with legal provisions. The judicial control of administrative acts represents a constitutional guarantee for citizens to protect their rights through public and fair trial by an independent and impartial court. In this way, the Constitution empowers the common administrative court that invalidates an action or administrative act, but not all administrative acts may be subject to administrative dispute, with the exception of cases against which the administrative conflict cannot be carried out (negative enumeration.

  16. Reviewing Illness Self-Management Programs: A Selection Guide for Consumers, Practitioners, and Administrators.

    Science.gov (United States)

    Petros, Ryan; Solomon, Phyllis

    2015-11-01

    Illness self-management (ISM) programs for adults with serious mental illness offer strategies to increase self-directed recovery activities to maximize wellness and increase independence from the service delivery system. This article describes five of the most popular ISM programs: Pathways to Recovery, The Recovery Workbook, Building Recovery of Individual Dreams and Goals through Education and Support, Wellness and Recovery Action Planning, and Illness Management and Recovery. It provides guidance for administrators, practitioners, and consumers for the purposes of selecting the program or programs providing the best fit. The framework for describing the five programs encompasses four contextual domains that supplement empirical evidence for a more comprehensive evaluation: structure, value orientation toward recovery, methods of teaching, and educational content. Contextual domains distinguish programs from one another, including length and time commitment, requisite resources, inclusion of group support, utilization of medical language and pathology, degree of traditional didactic education, and prioritization of consumer-driven self-exploration. The authors also searched PsycINFO, Google Scholar, and Cochrane Reviews for empirical evidence and evaluated the five programs on the strength of the evidence and the effectiveness of the intervention. Evidence of program effectiveness was found to range from low to moderate. However, empirical evidence alone is insufficient for selecting among the five programs, and contextual domains may offer the most relevant guidance by matching program features with goals of consumers, practitioners, and administrators. PMID:26129995

  17. 20 CFR 901.45 - Evidence.

    Science.gov (United States)

    2010-04-01

    ... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Evidence. 901.45 Section 901.45 Employees... § 901.45 Evidence. (a) In general. The rules of evidence prevailing in courts of law and equity are not... actuaries. However, the Administrative Law Judge shall exclude evidence which is irrelevant, immaterial,...

  18. 31 CFR 15.737-21 - Evidence.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Evidence. 15.737-21 Section 15.737-21... Administrative Enforcement Proceedings § 15.737-21 Evidence. (a) In general. The rules of evidence prevailing in... exclude evidence which is irrelevant, immaterial, or unduly repetitious. (b) Depositions. The...

  19. 40 CFR 164.81 - Evidence.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Evidence. 164.81 Section 164.81... (Other Than Expedited Hearings) The Hearings § 164.81 Evidence. (a) General. The Administrative Law Judge shall admit all relevant, competent and material evidence, except evidence that is unduly...

  20. Taking Time: Support for People with Cancer

    Science.gov (United States)

    ... type Progress Annual Report to the Nation Cancer Portfolio Snapshots Milestones in Cancer Research & Discovery Stories of ... Editorial Board Integrative Therapies Editorial Board Levels of Evidence Levels of Evidence: Treatment Levels of Evidence: Supportive & ...

  1. Transportation Security Administration

    Science.gov (United States)

    ... content Official website of the Department of Homeland Security CSS for FAQ Transportation Security Administration Search When I fly can I bring ... to know if you could bring through the security checkpoint. Main menu Administrator Travel Security Screening Special ...

  2. Administration on Aging

    Science.gov (United States)

    ... Federal Initiatives Career Opportunities Contact Us Administration on Aging (AoA) The Administration on Aging (AOA) is the ... themselves. Back to top Older Americans Act and Aging Network To meet the diverse needs of the ...

  3. Refinement for administrative policies

    OpenAIRE

    Dekker, M.A.C.; Etalle, S.

    2007-01-01

    Flexibility of management is an important requisite for access control systems as it allows users to adapt the access control system in accordance with practical requirements. This paper builds on earlier work where we defined administrative policies for a general class of RBAC models. We present a formal definition of administrative refinnement and we show that there is an ordering for administrative privileges which yields administrative refinements of policies. We argue (by giving an examp...

  4. Development of administrative justice

    OpenAIRE

    Švancrová, Dominika

    2014-01-01

    Bachelor's Thesis deals with a development of administrative justice. The first part of the paper defines the term of administrative justice in general and then describes various types. The second part is focused on the history of administrative justice in our country. The third part describes the current legislation in the Czech Republic. The fourth section is entirely devoted to the Supreme Administrative Court. Define the function and organization at first and then there are analyzed speci...

  5. Improvement of tax administration

    OpenAIRE

    Joppe, Aina

    2008-01-01

    The objective of the promotion work, based on the result analysis of the specific economical literature and tax administration praxis worldwide and in Latvia, is to elaborate proposals for the development of tax administration in Latvia. The work consists of three chapters. In the first chapter of the work viewpoints on the essence and functions of tax administration encountered in the scientific literature have been researched and factors affecting tax administration have been analyzed. T...

  6. Cloudera administration handbook

    CERN Document Server

    Menon, Rohit

    2014-01-01

    An easy-to-follow Apache Hadoop administrator's guide filled with practical screenshots and explanations for each step and configuration. This book is great for administrators interested in setting up and managing a large Hadoop cluster. If you are an administrator, or want to be an administrator, and you are ready to build and maintain a production-level cluster running CDH5, then this book is for you.

  7. Comparative studies on the administrative convergence revealed by national strategies of administrative reform in some South-Eastern European states

    OpenAIRE

    Lucica MATEI; Matei, Ani; Zanovschi, Diana; Stoian, Oana

    2010-01-01

    The paper has as main topic the administrative convergence and its reflection in the national strategies of administrative reform in some states in South Eastern Europe. Having a complex content, sometimes even ambigous, the administrative convergence will have as finality the integration in the European Administrative Space and the administrative reforms as support. From this prospect, the South-Eastern Europe has a certain specificity emphasised by: different positions of the states under d...

  8. 20 CFR 726.311 - Evidence.

    Science.gov (United States)

    2010-04-01

    ... Administrative Hearings Before the Office of Administrative Law Judges established by the Secretary at 29 CFR part 18 shall apply to administrative proceedings under this subpart. (b) Notwithstanding 29 CFR 18... 20 Employees' Benefits 3 2010-04-01 2010-04-01 false Evidence. 726.311 Section 726.311...

  9. Personality Traits and Administrators

    OpenAIRE

    Anitha V

    2008-01-01

    Administration is the art of getting tasks done by utilizing the resources and coordinating the people. Administrators give trigger to the administration by coordinating, and directing all parts of an organization by managing the tangible and intangible resources of the organization. The qualities of leadership are therefore a critical determinant of organizational success. The theories of leadership (Trait to Transformational leadership theory) have strived to look into the aspects that make...

  10. Self-Deploying Gossamer Support Structure Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Phase I results demonstrated the feasibility of using shape memory polymer composites to deploy, tension and support gossamer antennas. Cornerstone Research Group,...

  11. Status of nuclear forensic support in Sudan

    International Nuclear Information System (INIS)

    The central problem investigated in this thesis is nuclear forensic support in Sudan, the thesis comprises five chapters, began with an introduction containing the art of forensic science, stated the importance of the it in criminal investigations. The forensic science was defined, and stated the principle of which it underlying, including: principle of individuality and principle of exchange, the divisions of this science has been clarified, then it discussed the crime scene and the collecting of evidence, where starting the forensic science at the crime scene, with clarifying the principle of crime scene investigation. Nuclear and other radioactive material was discussed: defining a radioactivity with the material source. It placed into 3 general categories: special nuclear materials, reactor fuel, and commercial radioactive sources, and mention each category and it characteristics. Radiation is part of our environment was clarified, and discussed what the effect on organisms and populations are. Nuclear forensics was presented,and how problem of the safeguarding of the nuclear material beginning. The emerging nature of the problem was discussed, the radiological crime scene management was explained, importance of securing the scene with an examples of equipment and instruments for on-scene radiation safety assessment and how the collection of evidence, storage forensic laboratory analysis was discussed and how set the designated nuclear forensic laboratory, also nuclear forensic interpretation, and the chain of custody was mentioned. The role of Regulating Authority in Nuclear forensic support was discussed, specifically in Sudan, International Cooperation have also been reminded, as well as memorandum of understanding was mentioned between SNRRA and the administration of forensic evidence, and one of it results is the radiological surveys unit in forensic administration, how the unit is configured, the role of the unit, finally conclusion of research was

  12. Veterans Administration Databases

    Science.gov (United States)

    The Veterans Administration Information Resource Center provides database and informatics experts, customer service, expert advice, information products, and web technology to VA researchers and others.

  13. Incorporating sustainable development objectives into land administration

    DEFF Research Database (Denmark)

    Williamson, Ian; Enemark, Stig; Wallace, Jude

    2006-01-01

    democracies and in Australia were identified. The European approach showed more integration between the standard LAS activities and measures of sustainability. Australian policy was more fractured, partly due to federation and the constitutional distribution of powers. In contrast, Australian LAS pioneering......Historically, land administration systems (LAS) were built to support land markets and land taxation systems. In developed countries, these systems constitute substantial infrastructure provided through government for the benefit of overall public administration, citizens and businesses...

  14. CDS - Database Administrator's Guide

    Science.gov (United States)

    Day, J. P.

    This guide aims to instruct the CDS database administrator in: o The CDS file system. o The CDS index files. o The procedure for assimilating a new CDS tape into the database. It is assumed that the administrator has read SUN/79.

  15. Koncepcja lean administration

    OpenAIRE

    Czekaj, Janusz

    2010-01-01

    The article presents an attempt of description of Lean Administration concept. The pre- requisites and principles of Lean Administration system is given. Next, the functions and perspectives of “lean” activities are discussed together with methodological framework. The steps and auxiliary methods are also defined.

  16. Webmin administrator's cookbook

    CERN Document Server

    Karzynski, Michal

    2014-01-01

    Written in a cookbook format with practical recipes this book helps you to perform various administrative tasks using Webmin and enables you to perform common jobs more efficiently.This book is perfect for System administrators who want to learn more advanced concepts of Webmin and how it can help to set up a server for development, testing or deployment.

  17. Understanding land administration systems

    DEFF Research Database (Denmark)

    P. Williamson, Ian; Enemark, Stig; Wallace, Judy;

    2008-01-01

    This paper introduces basic land administration theory and highlights four key concepts that are fundamental to understanding modern land administration systems. Readers may recall the first part of the paper in October issue of Coordinates. Here is the concluding part that focuses on the changing...

  18. Postmodern Public Administration

    DEFF Research Database (Denmark)

    Bogason, Peter

    2005-01-01

    Discussion of the trends towards more uses of postmodern analysis within the discipline of public administration, particularly in the USA......Discussion of the trends towards more uses of postmodern analysis within the discipline of public administration, particularly in the USA...

  19. Centos system administration essentials

    CERN Document Server

    Mallett, Andrew

    2014-01-01

    If you are a Linux administrator who is looking to gain knowledge that differentiates yourself from the crowd, then this is the book for you. Beginners who have a keen interest to learn more about Linux administration will also progress quickly with this resourceful learning guide.

  20. Administration for Student Development.

    Science.gov (United States)

    Bergen, J. J., Ed.

    This collection of papers focuses on school administration and its relation to students. It is contended that toay's student matures earlier; has higher expectations; is more affluent; is more isolated from adults; is more critical and outspoken; and, therefore, must be heard by teachers and administrators. A related document is EA 001578.…

  1. Oral administration of taxanes

    NARCIS (Netherlands)

    Malingré, M.M.

    2002-01-01

    Oral treatment with cytotoxic agents is to be preferred as this administration route is convenient to patients, reduces administration costs and facilitates the use of more chronic treatment regimens. For the taxanes paclitaxel and docetaxel, however, low oral bioavailability has limited development

  2. Test Administration Models

    Science.gov (United States)

    Becker, Kirk A.; Bergstrom, Betty A.

    2013-01-01

    The need for increased exam security, improved test formats, more flexible scheduling, better measurement, and more efficient administrative processes has caused testing agencies to consider converting the administration of their exams from paper-and-pencil to computer-based testing (CBT). Many decisions must be made in order to provide an optimal…

  3. Windows Vista Administrator's Pocket Guide

    CERN Document Server

    Stanek, William R

    2007-01-01

    Portable and precise, this pocket-sized guide delivers immediate answers for the day-to-day administration of Windows Vista. Zero in on core support and maintenance tasks using quick-reference tables, instructions, and lists. You'll get the precise information you need to solve problems and get the job done-whether you're at your desk or in the field! Get fast facts to: Install and configure Windows Vista-and optimize the user workspaceMaintain operating system components, hardware devices, and driversCreate user and group accounts-and control rights and permissionsAdminister group policy se

  4. 5 CFR 842.804 - Evidence.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Evidence. 842.804 Section 842.804... Controllers § 842.804 Evidence. (a) An agency head's determination under § 842.803(a) (finding that a position...) must be based on the official position description and any other evidence deemed appropriate by...

  5. 5 CFR 831.905 - Evidence.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Evidence. 831.905 Section 831.905...) RETIREMENT Law Enforcement Officers and Firefighters § 831.905 Evidence. (a) An agency head's determination... determination under § 831.904 must be based on the official position description and any other evidence...

  6. 7 CFR 15.117 - Evidence.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 1 2010-01-01 2010-01-01 false Evidence. 15.117 Section 15.117 Agriculture Office of... and Administrative Review Under the Civil Rights Act of 1964 Hearing Procedures § 15.117 Evidence. Irrelevant, immaterial, unreliable, and unduly repetitious evidence will be excluded, and technical rules...

  7. 28 CFR 71.34 - Evidence.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Evidence. 71.34 Section 71.34 Judicial... REMEDIES ACT OF 1986 Implementation for Actions Initiated by the Department of Justice § 71.34 Evidence. (a) The ALJ shall determine the admissibility of evidence. (b) Except as provided in this part, the...

  8. 5 CFR 842.905 - Evidence.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Evidence. 842.905 Section 842.905... EMPLOYEES RETIREMENT SYSTEM-BASIC ANNUITY Nuclear Materials Couriers § 842.905 Evidence. (a) The Secretary... official position description and any other evidence deemed appropriate by the agency head for making...

  9. 5 CFR 831.805 - Evidence.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Evidence. 831.805 Section 831.805...) RETIREMENT Nuclear Materials Couriers § 831.805 Evidence. (a) The Secretary of Energy's determination under... other evidence deemed appropriate by the agency head for making the determination. (c) If an employee...

  10. 45 CFR 160.540 - Evidence.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Evidence. 160.540 Section 160.540 Public Welfare... ADMINISTRATIVE REQUIREMENTS Procedures for Hearings § 160.540 Evidence. (a) The ALJ must determine the admissibility of evidence. (b) Except as provided in this subpart, the ALJ is not bound by the Federal Rules...

  11. 28 CFR 68.40 - Evidence.

    Science.gov (United States)

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Evidence. 68.40 Section 68.40 Judicial... IMMIGRATION-RELATED EMPLOYMENT PRACTICES, AND DOCUMENT FRAUD § 68.40 Evidence. (a) Applicability of Federal rules of evidence. Unless otherwise provided by statute or these rules, the Federal Rules of...

  12. 13 CFR 134.312 - Evidence.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Evidence. 134.312 Section 134.312 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION RULES OF PROCEDURE GOVERNING CASES BEFORE THE... Designations § 134.312 Evidence. To the extent the rules in this subpart permit the submission of evidence,...

  13. 45 CFR 150.445 - Evidence.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Evidence. 150.445 Section 150.445 Public Welfare... AND INDIVIDUAL INSURANCE MARKETS Administrative Hearings § 150.445 Evidence. (a) The ALJ will determine the admissibility of evidence. (b) Except as provided in this part, the ALJ will not be bound...

  14. 45 CFR 79.34 - Evidence.

    Science.gov (United States)

    2010-10-01

    ... 45 Public Welfare 1 2010-10-01 2010-10-01 false Evidence. 79.34 Section 79.34 Public Welfare DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION PROGRAM FRAUD CIVIL REMEDIES § 79.34 Evidence. (a) The ALJ shall determine the admissibility of evidence. (b) Except as provided in this part,...

  15. Intraoral administration of botulinum toxin for trigeminal neuropathic pain.

    Science.gov (United States)

    Herrero Babiloni, Alberto; Kapos, Flavia P; Nixdorf, Donald R

    2016-06-01

    This article presents 2 cases of different neuropathic trigeminal pain conditions treated with intraoral botulinum toxin injections. There is a growing body of evidence to support the use of this substance when administered subcutaneously in the treatment of neuropathic pain, such as in extraoral injections for trigeminal neuralgia. However, reports of intraoral submucosal administration are still lacking. In the 2 cases presented here, neuropathic pain was refractory to treatment with an important intraoral peripheral component, so onabotulinum toxin A was introduced as an adjuvant therapy. The technique, doses, and dilution are discussed. The patients reported significant reductions in pain frequency and intensity, with minimal side effects of temporary mucosal dryness and smile droopiness. The analgesic benefits of botulinum toxin may be utilized to address intraoral neuropathic pain. Further studies are needed to confirm safety and effectiveness in larger samples. PMID:27181448

  16. Evidências de validade entre a Escala de Depressão (EDEP, o BDI e o Inventário de Percepção de Suporte Familiar (IPSF Validity evidences between the Depression Scale (EDEP, the BDI and the Perception of Family Support Inventory (IPSF

    Directory of Open Access Journals (Sweden)

    Makilim Nunes Baptista

    2008-12-01

    's family support, understood as manifestation of attention, care, dialog, freedom, affective proximity, autonomy and independence between family members. The present research aimed to search for validity evidences to Depression Scale (EDEP based on the relation to other variables assessing the same construct, depression, being also assessed by Beck Depression Inventory - BDI, and assessing related constructs, family support, measured by Perception of Family Support Inventory - IPSF. 157 undergraduates from a private university located in south state of Minas Gerais, 75,5% from female gender and 24,5% from male gender, aging from 18 to 51 years old (M=23,2; DP=6,4 took part in this study. At the results, high, significant and positive correlations were found between EDEP and BDI, as expected, indicating that the higher the scores on both scales, higher the depressive symptoms. As for the correlations between EDEP and IPSF dimensions, significant and negative correlations were found, suggesting that the higher depressive symptoms lower the perception of family support on individuals. Only marginally significant differences were found between genders, as to depressive symptoms (EDEP and BDI, indicating that women would score more at the depression scales.

  17. Both economic theory and evidence from the UK shows that state-funded healthcare which incorporates market-type incentives will save more lives and reduce more suffering

    OpenAIRE

    Le Grand, Julian

    2012-01-01

    Commentary by Allyson Pollock et al misrepresents the findings of economic analyses of quasi-markets says Julian Le Grand. Looking at the evidence (and recognizing the defects of state agencies’ administration of healthcare) shows that quasi-markets with fixed prices perform better. Competitive mechanisms in the NHS were also supported by previous Labour reforms

  18. PUBLICATION OF ADMINISTRATIVE CIRCULAR

    CERN Multimedia

    HR Department

    2008-01-01

    ADMINISTRATIVE CIRCULAR NO. 23 (REV. 2) – SPECIAL WORKING HOURS Administrative Circular No. 23 (Rev. 2) entitled "Special working hours", approved following discussion in the Standing Concertation Committee meeting of 9 December 2008, will be available on the intranet site of the Human Resources Department as from 19 December 2008: http://cern.ch/hr-docs/admincirc/admincirc.asp It cancels and replaces Administrative Circular No. 23 (Rev. 1) entitled "Stand-by duty" of April 1988. A "Frequently Asked Questions" information document on special working hours will also be available on this site. Paper copies of this circular will shortly be available in departmental secretariats. Human Resources Department Tel. 78003

  19. Publication of administrative circular

    CERN Multimedia

    HR Department

    2009-01-01

    ADMINISTRATIVE CIRCULAR NO. 23 (REV. 2) – SPECIAL WORKING HOURS Administrative Circular No. 23 (Rev. 2) entitled "Special working hours", approved following discussion in the Standing Concertation Committee on 9 December 2008, will be available on the intranet site of the Human Resources Department as from 19 December 2008: http://cern.ch/hr-docs/admincirc/admincirc.asp It cancels and replaces Administrative Circular No. 23 (Rev. 1) entitled "Stand-by duty" of April 1988. A "Frequently Asked Questions" information document on special working hours will also be available on this site. Paper copies of this circular will shortly be available in Departmental Secretariats. Human Resources Department Tel. 78003

  20. Pro Linux System Administration

    CERN Document Server

    Turnbull, James

    2009-01-01

    We can all be Linux experts, provided we invest the time in learning the craft of Linux administration. Pro Linux System Administration makes it easy for small to medium--sized businesses to enter the world of zero--cost software running on Linux and covers all the distros you might want to use, including Red Hat, Ubuntu, Debian, and CentOS. Authors, and systems infrastructure experts James Turnbull, Peter Lieverdink, and Dennis Matotek take a layered, component--based approach to open source business systems, while training system administrators as the builders of business infrastructure. If

  1. Humanism, Administration and Education

    DEFF Research Database (Denmark)

    Plum, Maja

    2012-01-01

    argued that the changes in administrative practices during the last decade constitute a transformation, but also a reproduction of relations between knowledge and governing that goes back to the big expansion of the welfare state. Second, it is argued that these relations between knowledge and governing...... are not restricted to the administrative practices, but are part of education and its humanistic legacy as well. As such, the administrative demand of documentation becomes possible and recognisable through its reproductive elements. Elements that are constituted in a transformative conjunction in...

  2. A New Fusion Method for Conflicting Evidence

    Institute of Scientific and Technical Information of China (English)

    彭颖; 沈怀荣; 马永一

    2011-01-01

    A new conflicting evidence fusion method is proposed for the deficiency of Dempster' s rule which can not fuse the conflicting evidence. Evidence is divided into three categories: believable evidence, non-conflicting evidence and con- flicting evidence. The influences of these three categories of evidences on fusion results when discounted are analyzed respectively. On these bases, the evidence distance and the conjunctive conflict are utilized in sequence to recognize the be- lievable evidence and non-conflicting evidence. The discounting factors of these two categories of evidences are set to one, which keeps the evidences support the true hypothesis to the greatest degree, and makes the fusion results focus onto the true hypothesis. Examples of some missile fault diagnosis show that the new method can effectively fuse the conflicting evidences, and is suited to fuse the relievable evidences. The new method improves the reliability and rationality of fusion re- sults compared with traditional methods.

  3. Nutritional Support

    Science.gov (United States)

    Nutritional support is therapy for people who cannot get enough nourishment by eating or drinking. You may need ... absorb nutrients through your digestive system You receive nutritional support through a needle or catheter placed in your ...

  4. Veterans Health Administration (VHA)

    Data.gov (United States)

    Social Security Administration — The purpose of this agreement is for SSA to verify SSNs and other identifying information for the Department of Veterans Affairs, VHA. DVA will use the information...

  5. Scientists vs. the administration

    CERN Multimedia

    2004-01-01

    Article denouncing the supposed impartiality of signatories of a report released by the Union of Concerned Scientists (UCS), which accused the Bush administration of systemically suborning objective science to a political agenda (1 page).

  6. Administrative Discretionary Grant Data

    Data.gov (United States)

    Institute of Museum and Library Services — This dataset of administrative records contains discretionary grant recipients who were awarded funds by the Institute of Museum and Library Services from fiscal...

  7. Fiscal year 1986, Department of Energy authorization (magnetic fusion energy and departmental administration and supporting services activities). Volume V. Hearings before the Subcommittee on Energy Research and Production of the Committee on Science and Technology, House of Representatives, Ninety-Ninth Congress, First Session, March 8, 18, 1985

    International Nuclear Information System (INIS)

    Volume V of the hearing record covers testimony given over two days on budgets for research on magnetic fusion energy and on the administration and support services of the DOE. The principal witness on the first day was Dr. Alvin Trivelpiece of DOE, who described adjustments in fusion funding that resulted from federal budget cuts. These led to delay and deferments in the program, and raised the issue of how to maintain balance in the program and still meet program goals. Trivelpiece emphasized that cuts for fusion research were consistent with other DOE reductions. Testimony on the second day came from representatives of fusion laboratories and the nuclear industry. Two appendices with additional questions and answers submitted for the record follow the testimony of the 16 witnesses

  8. Education of System Administration

    OpenAIRE

    Feyrer, Hubert

    2007-01-01

    This article discusses education of system administration. Theoretical foundations cover psychology, learning theory, instruction theory, and instructional design, leading to an ideal progression for education, and related tools. The main part describes an existing class on system administration as given at the University of Applied Sciences (Fachhochschule, FH) Regensburg, Germany. It is analyzed for its history and target audience, the current curriculum, course layout, and for the didac...

  9. SELinux policy administration

    CERN Document Server

    Vermeulen, Sven

    2013-01-01

    A step-by-step guide to learn how to set up security on Linux servers by taking SELinux policies into your own hands.Linux administrators will enjoy the various SELinux features that this book covers and the approach used to guide the admin into understanding how SELinux works. The book assumes that you have basic knowledge in Linux administration, especially Linux permission and user management.

  10. Corruption in public administration

    OpenAIRE

    Rosecký, Radek

    2012-01-01

    This dissertation deals with the topic of the corruption in a public administration. It is aimed at an identification of key corruption threats which are typical for a public administration, further at an analysis of the corruption causes and its forms, an identification of its developmental stages, including the analysis of current anti-corruption measures and drafts to an optimal answer within the Czech Republic. The theoretical part of this dissertation in its indroduction contents the ...

  11. Active City Administration

    OpenAIRE

    M .R. Sindhu; Viraj M. Jamle; Pramod M. Shelke; Shrikant G. Baheti

    2012-01-01

    The basic and universal corner stone of good governance are quality of service, quick response mechanisms and above all accountable and transparent process mechanism. The active city administration initiatives resulted in computerization of the legacy systems in government with limited ability to internalize the advances in information and communication technologies.By using active city administration services we able to know real time, quantitative and basic approach of the government servic...

  12. 31 CFR 315.23 - Evidence.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Evidence. 315.23 Section 315.23 Money... Caveats Permitted § 315.23 Evidence. (a) General. To establish the validity of judicial proceedings... supported by appropriate evidence of appointment and qualification. The evidence must be certified by...

  13. 31 CFR 360.23 - Evidence.

    Science.gov (United States)

    2010-07-01

    ... 31 Money and Finance: Treasury 2 2010-07-01 2010-07-01 false Evidence. 360.23 Section 360.23 Money... BONDS, SERIES I Judicial Proceedings § 360.23 Evidence. (a) General. To establish the validity of... must be supported by appropriate evidence of appointment and qualification. The evidence must...

  14. Intrathecal drug administration in chronic pain syndromes.

    Science.gov (United States)

    Ver Donck, Ann; Vranken, Jan H; Puylaert, Martine; Hayek, Salim; Mekhail, Nagy; Van Zundert, Jan

    2014-06-01

    Chronic pain may recur after initial response to strong opioids in both patients with cancer and patients without cancer or therapy may be complicated by intolerable side effects. When minimally invasive interventional pain management techniques also fail to provide satisfactory pain relief, continuous intrathecal analgesic administration may be considered. Only 3 products have been officially approved for long-term intrathecal administration: morphine, baclofen, and ziconotide. The efficacy of intrathecal ziconotide for the management of patients with severe chronic refractory noncancer pain was illustrated in 3 placebo-controlled trials. A randomized study showed this treatment option to be effective over a short follow-up period for patients with pain due to cancer or AIDS. The efficacy of intrathecal opioid administration for the management of chronic noncancer pain is mainly derived from prospective and retrospective noncontrolled trials. The effect of intrathecal morphine administration in patients with pain due to cancer was compared with oral or transdermal treatment in a randomized controlled trial, which found better pain control and fewer side effects with intrathecal opioids. Other evidence is derived from cohort studies. Side effects of chronic intrathecal therapy may either be technical (catheter or pump malfunction) or biological (infection). The most troublesome complication is, however, the possibility of granuloma formation at the catheter tip that may induce neurological damage. Given limited studies, the evidence for intrathecal drug administration in patients suffering from cancer-related pain is more compelling than that of chronic noncancer pain. PMID:24118774

  15. Barcode Medication Administration: Supporting Transitions in Articulation Work

    OpenAIRE

    Novak, Laurie L.; Lorenzi, Nancy M.

    2008-01-01

    Articulation work is that which enables coordinated activity among colleagues distributed in time and space. Despite its important role in clinical settings, this work remains largely invisible in process flowcharts. When process-oriented information systems are implemented, the informal, flexible, contingent activities of participants that enable coordinated work are suddenly placed in a new context. Articulation work must adapt to new contexts of automation, and there are opportunities for ...

  16. Adapting to the Pedagogy of Technology in Educational Administration

    Science.gov (United States)

    Berry, James E.; Marx, Gary

    2010-01-01

    The field of educational administration is in a pedagogical transition. Though empirical evidence may be lacking about the efficacy of online teaching and learning, programs in educational administration are part of the greater movement to Internet delivery by virtue of market forces and advances in software and hardware tools for teaching in a…

  17. Men and Women in Educational Administration Programs.

    Science.gov (United States)

    Marshall, Catherine

    1984-01-01

    Examined the effects of a graduate program in education administration on women's career mobility, in a survey of 165 male and female students. Results showed women students are older and have less financial support, lower positions, and lower career goals, indicating the program does not promote equal opportunity. (JAC)

  18. Child Support

    OpenAIRE

    Bradshaw, J. (Jonathan)

    2006-01-01

    Child support is a private transfer, which for many people is mediated by the government, and which mainly benefits lone parents. Children in lone parent families represented 42 per cent of all poor children in 2003/4. Therefore child support might play an important part in reducing child poverty. Although this was not an aspiration of the 1991 Child Support Act it was certainly the main aspiration of the Child Support, Pensions and Social Security Act 2000. This paper is a review of the pote...

  19. Peer Support.

    Science.gov (United States)

    Forchuk, Cheryl; Solomon, Michelle; Viran, Tazim

    2016-01-01

    The Mental Health Commission of Canada defines peer support as "a supportive relationship between people who have a lived experience in common … in relation to a mental health challenge or illness … related to their own mental health or that of a loved one" (Sunderland et al. 2013: 11). In Ontario, a key resource for peer support is the Ontario Peer Development Initiative (OPDI), which is an umbrella organization of mental health Consumer/Survivor Initiatives (CSIs) and peer support organizations across the province of Ontario. Member organizations are run by and for people with lived experience of a mental health or addiction issue and provide a wide range of services and activities within their communities. The central tenet of member organizations is the common understanding that people can and do recover with the proper supports in place and that peer support is integral to successful recovery. Nationally, Peer Support Accreditation and Certification Canada has recently been established. The relatively new national organization focuses on training and accrediting peer support workers. This paper focuses on a range of diverse peer support groups and CSIs that operate in London and surrounding areas. PMID:26854546

  20. Behavioral Public Administration: Combining Insights from Public Administration and Psychology

    OpenAIRE

    Grimmelikhuijsen, Stephan; Jilke, Sebastian; Olsen, Asmus Leth; Tummers, Lars

    2015-01-01

    We propose behavioral public administration as a designated subfield in public administration which explicitly deals with the integration of theories and methods from psychology into the study of public administration. We discuss how scholars in public administration currently draw on both methodological and theoretical innovations in psychology and point to research questions in public administration which could benefit from further integration. Behavioral public administration cannot, and s...

  1. Spatially enabled land administration

    DEFF Research Database (Denmark)

    Enemark, Stig

    2006-01-01

    other words: Good governance and sustainable development is not attainable without sound land administration or - more broadly – sound land management. The paper presents a land management vision that incorporates the benefits of ICT enabled land administration functions. The idea is that spatial......Good governance is a qualitative term or an ideal which may be difficult to achieve. Different people, organisations, and government authorities will define “good governance” according to their own experience and interests. In any case, almost all kind of government includes a spatial component. In...... enabling of land administration systems managing tenure, valuation, planning, and development will allow the information generated by these activities to be much more useful. Also, the services available to private and public sectors and to community organisations should commensurably improve. Knowledge...

  2. Linux System Administration

    CERN Document Server

    Adelstein, Tom

    2007-01-01

    If you're an experienced system administrator looking to acquire Linux skills, or a seasoned Linux user facing a new challenge, Linux System Administration offers practical knowledge for managing a complete range of Linux systems and servers. The book summarizes the steps you need to build everything from standalone SOHO hubs, web servers, and LAN servers to load-balanced clusters and servers consolidated through virtualization. Along the way, you'll learn about all of the tools you need to set up and maintain these working environments. Linux is now a standard corporate platform with user

  3. Computer hardware fault administration

    Science.gov (United States)

    Archer, Charles J.; Megerian, Mark G.; Ratterman, Joseph D.; Smith, Brian E.

    2010-09-14

    Computer hardware fault administration carried out in a parallel computer, where the parallel computer includes a plurality of compute nodes. The compute nodes are coupled for data communications by at least two independent data communications networks, where each data communications network includes data communications links connected to the compute nodes. Typical embodiments carry out hardware fault administration by identifying a location of a defective link in the first data communications network of the parallel computer and routing communications data around the defective link through the second data communications network of the parallel computer.

  4. Pro Python System Administration

    CERN Document Server

    Sileika, R

    2010-01-01

    As time goes on, system administrators are presented with increasingly complicated challenges. In the early days, a team of engineers might have had to look after one or two systems. These days, one engineer can administer hundreds or thousands of systems. System administrators are gradually replacing their tools with more advanced and flexible ones. One of the choices is Python. Structurally, Python is a modern, high-level language with a very clean syntax. Python comes with many built-in libraries that can make automation tasks easier. It also has extensive set of third-party libraries and a

  5. Practical JIRA Administration

    CERN Document Server

    Doar, Matthew

    2011-01-01

    If you're familiar with JIRA for issue tracking, bug tracking, and other uses, you know it can sometimes be tricky to set up and manage. In this concise book, software toolsmith Matt Doar clarifies some of the more confusing aspects by answering difficult and frequently asked questions about JIRA administration. Practical JIRA Administration shows you how JIRA is intended to be used, making it an ideal supplement to the extensive documentation already available. The book's chapters are loosely connected, so you can go straight to the information that best serves your needs. Understand the di

  6. Positioning support

    International Nuclear Information System (INIS)

    A positioning support for infants during X-ray examinations is described. The support which can be placed on the X-ray examination table has a simple structure and can easily be handled. It guarantees a stable positioning of the patient at a short object-film distance

  7. The impact on the accounting information after the implementation of an integrated system of administration in the federal institutions of higher education.

    OpenAIRE

    Josué Viana de Oliveira Neto

    2005-01-01

    This article presents a research is intended to verify theories that explain the process of implementation of an Integrated System of Administration (ISA) in an organization, analyzing the effects on the use of accounting information. The empiric work based on a case study an organization that implemented of an ISA which main objective is to produce analytical reports integrated. The found evidences support the propositions done by Walton (1993:14) which describes the integration of the infor...

  8. United States Fire Administration

    Science.gov (United States)

    ... Reduction: Getting the Most From the U.S. Fire Administration’s Daily National Operations Brief PDF 127 KB There ... staff. Follow us: Twitter Facebook YouTube U.S. Fire Administration 16825 S. Seton Ave. , Emmitsburg , MD 21727 USA 800‑ ...

  9. Student Panels, Business Administration

    DEFF Research Database (Denmark)

    Rask, Morten

    the Head of MSc programmes, the MSc coordinator as well as the administrative secretary. A student panel meets with the department twice in the first year: Early in February to sum up experience from the first semester and in early in June to sum up experience from the second semester. At semester...

  10. The persuasive administrator.

    Science.gov (United States)

    Davidhizar, Ruth

    2002-01-01

    The art of being persuasive involves use of selected persuasive techniques appropriate to the individual and situation. Persuasive techniques are powerful tools of communication and productivity. Effective use of persuasive techniques can provide motivation to others and can mobilize them toward action that you, as an administrator, desire. PMID:11962076

  11. Enterprise Mac administrators guide

    CERN Document Server

    Smith, William

    2015-01-01

    IT departments everywhere will be integrating Macs and Mac OS X into their IT infrastructure and this book will tell them how to do it. It will serve as an authoritative, useful and frequently referenced book on Mac OS X administration.

  12. 5 CFR 831.1109 - Evidence.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Evidence. 831.1109 Section 831.1109 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE REGULATIONS (CONTINUED... exhibit of a documentary character shall be submitted to the presiding officer, duly marked, and made...

  13. Tax compliance costs: a business administration perspective

    OpenAIRE

    Eichfelder, Sebastian; Schorn, Michael

    2009-01-01

    The paper analyses the relationship of tax compliance costs and business strategy. Due to instruments, like information technology, simplified cash accounting or outsourcing compliance activities to tax advisers, private businesses have a set of strategies to optimize their tax compliance cost burden. Under the assumption of rational choice a private business should choose a cost-optimal administration strategy. In spite of that we find empirical evidence for small German businesses using onl...

  14. Empowering Secondary School Teachers Through Administrative Tasks

    OpenAIRE

    Magdalena M. Ocbian; Maricel Ayala-Dichoso

    2015-01-01

    One prevalent problem confronting small schools is the unavailability of non-teaching staff that can serve the school in its financial and reportorial matters. This study looked into the need of small schools to establish their own school organizational staff that would aid the school head to be efficient in the financial and reportorial matters. This scenario is evident in Buhatan National High School (BNHS) where the school head delegated administrative functions to teachers. This case stud...

  15. What is Evidence? (editorial

    Directory of Open Access Journals (Sweden)

    Denise Koufogiannakis

    2011-06-01

    that have stood the test of time and still hold relevance for today. Our EBL101 column is similar in that it synthesizes small aspects of evidence based practice or research that help educate the reader about particular elements of evidence based practice. Finally, we publish Commentaries and the Using Evidence in Practice section, which provide practitioner insights and reflections about their work at a local level. These are useful in helping readers apply similar strategies to their own practice, or imbue them with ideas from which their own evaluation of their practice can occur. Commentaries also allow new ideas to take shape, or critiques of particular aspects of evidence based practice, to reach readers, allowing for continued discussion and debate.Pulling together the published evidence with local evidence and insights is not an easy task. I think it resides in each individual professional who wishes to do their best work while including research evidence to support that work. Talking about being evidence based and making explicit some of the factors that do not make this process an easy one, is one of the first steps to enabling the process to become more meaningful and allow individual practitioners to have ownership of it in their own way.

  16. Oral ondansetron administration in emergency departments to children with gastroenteritis: an economic analysis.

    Directory of Open Access Journals (Sweden)

    Stephen B Freedman

    2010-10-01

    Full Text Available BACKGROUND: The use of antiemetics for children with vomiting is one of the most controversial decisions in the treatment of gastroenteritis in developed countries. Ondansetron, a selective serotonin receptor antagonist, has been found to be effective in improving the success of oral rehydration therapy. However, North American and European clinical practice guidelines continue to recommend against its use, stating that evidence of cost savings would be required to support ondansetron administration. Thus, an economic analysis of the emergency department administration of ondansetron was conducted. The primary objective was to conduct a cost analysis of the routine administration of ondansetron in both the United States and Canada. METHODS AND FINDINGS: A cost analysis evaluated oral ondansetron administration to children presenting to emergency departments with vomiting and dehydration secondary to gastroenteritis from a societal and health care payer's perspective in both the US and Canada. A decision tree was developed that incorporated the frequency of vomiting, intravenous insertion, hospitalization, and emergency department revisits. Estimates of the monetary costs associated with ondansetron use, intravenous rehydration, and hospitalization were derived from administrative databases or emergency department use. The economic burden in children administered ondansetron plus oral rehydration therapy was compared to those not administered ondansetron employing deterministic and probabilistic simulations. We estimated the costs or savings to society and health care payers associated with the routine administration of ondansetron. Sensitivity analyses considered variations in costs, treatment effects, and exchange rates. In the US the administration of ondansetron to eligible children would prevent approximately 29,246 intravenous insertions and 7,220 hospitalizations annually. At the current average wholesale price, its routine administration

  17. Radiation Therapy and You: Support for People with Cancer

    Science.gov (United States)

    ... type Progress Annual Report to the Nation Cancer Portfolio Snapshots Milestones in Cancer Research & Discovery Stories of ... Editorial Board Integrative Therapies Editorial Board Levels of Evidence Levels of Evidence: Treatment Levels of Evidence: Supportive & ...

  18. Effect of levothyroxine administration on hemostatic analytes in Doberman Pinschers with von Willebrand disease.

    Science.gov (United States)

    Heseltine, Johanna C; Panciera, David L; Troy, Gregory C; Monroe, William E; Brooks, Marjory B; Feldman, Bernard F

    2005-01-01

    Levothyroxine administration has been suggested to be an effective treatment for canine von Willebrand disease (vWd), but evidence supporting this treatment is lacking. Effects of levothyroxine administration were evaluated in 8 euthyroid Doberman Pinschers with plasma von Willebrand factor (vWf) concentrations 70%). Response to placebo versus levothyroxine treatment was not significantly different between groups at day 0, 2, or 30 for BMBT, vWf:Ag, vWf:CBA, and FVIII:C. Serum T4, fT4, and T3 concentrations were significantly higher and serum TSH significantly lower in the levothyroxine-treated group than in the placebo group at days 2 and 30. Administration of levothyroxine at 0.04 mg/kg caused laboratory evidence of hyperthyroidism but did not affect plasma FVIII:C and vWf:Ag concentrations or vWf-dependent collagen binding and BMBT. The results of this study failed to identify a direct action of levothyroxine supplementation on plasma vWf concentration or activity in euthyroid Doberman Pinschers with vWd. PMID:16095169

  19. Behavioral Public Administration: Combining Insights from Public Administration and Psychology

    DEFF Research Database (Denmark)

    Grimmelikhuijsen, Stephan; Jilke, Sebastian; Olsen, Asmus Leth;

    2015-01-01

    We propose behavioral public administration as a designated subfield in public administration which explicitly deals with the integration of theories and methods from psychology into the study of public administration. We discuss how scholars in public administration currently draw on both...... methodological and theoretical innovations in psychology and point to research questions in public administration which could benefit from further integration. Behavioral public administration cannot, and should not, replace ‘conventional’ public administration, but it is complementary to it. Importantly......, behavioral public administration represents a two-way street in which public administration scholars use theories and methods from psychology, and psychologists, in turn, learn from our setting of political-administrative contexts to refine their theories and methods. Finally, we propose four principals to...

  20. Land Administration Systems

    DEFF Research Database (Denmark)

    Enemark, Stig

    2014-01-01

    Land administration systems are the operational tool for conceptualizing rights, restrictions and responsibilities (RRRs) in land. Each of the rights, restrictions and responsibilities encompasses a human rights dimension that relates to the overall national land policies and should be unfolded as...... more than just rhetoric. This paper attempts to analyse the aspects of human rights in relation to land administration systems with a special focus on developing countries struggling to build adequate systems for governing the rights, restrictions and responsibilities in land. Human rights are the...... of being alive. Of special interest in relation to land and property is the right to own things and the right of food and adequate housing for all. More generally, human rights should be seen as an ethical responsibility of government to ensure that people enjoy some basic rights as human beings...

  1. ATLAS TDAQ System Administration:

    CERN Document Server

    Lee, Christopher Jon; The ATLAS collaboration; Bogdanchikov, Alexander; Ballestrero, Sergio; Contescu, Alexandru Cristian; Dubrov, Sergei; Fazio, Daniel; Korol, Aleksandr; Scannicchio, Diana; Twomey, Matthew Shaun; Voronkov, Artem

    2015-01-01

    The ATLAS Trigger and Data Acquisition (TDAQ) system is responsible for the online processing of live data, streaming from the ATLAS experiment at the Large Hadron Collider (LHC) at CERN. The online farm is composed of ̃3000 servers, processing the data readout from ̃100 million detector channels through multiple trigger levels. During the two years of the first Long Shutdown (LS1) there has been a tremendous amount of work done by the ATLAS TDAQ System Administrators, implementing numerous new software applications, upgrading the OS and the hardware, changing some design philosophies and exploiting the High Level Trigger farm with different purposes. During the data taking only critical security updates are applied and broken hardware is replaced to ensure a stable operational environment. The LS1 provided an excellent opportunity to look into new technologies and applications that would help to improve and streamline the daily tasks of not only the System Administrators, but also of the scientists who wil...

  2. Law Tackling Administrative Monopolies

    Institute of Scientific and Technical Information of China (English)

    WAN LIXIN

    2006-01-01

    @@ The long-anticipated anti-monopoly law needs to better address the crucial distinction between administrative and economic monopolies The first five months of 2oo6 saw a surge in the profits achieved by key State enterprises, especially in the eight sectors including petroleum, telecommunication and electricity, which achieved 285 billion yuan (US$36 billion) in profits, accounting for about 86 percent of the total, according to a July report. From the Stateowned Assets Supervision and Administration Commission of the State (SASAC). This news was both heartening and disquieting, for the most profitable sectors happen to be monopolistic enterprises, mostly upstream the production chain, who achieve their profitability at the expense of those companies further downstream. For years these sectors have been at the centre of the "bust-the-trust" storm.

  3. IPv6 Network Administration

    CERN Document Server

    Murphy, Niall Richard

    2009-01-01

    This essential guide explains what works, what doesn't, and most of all, what's practical about IPv6--the next-generation Internet standard. A must-have for network administrators everywhere looking to fix their network's scalability and management problems. Also covers other IPv6 benefits, such as routing, integrated auto-configuration, quality-of-services (QoS), enhanced mobility, and end-to-end security.

  4. Flexible Land Administration

    DEFF Research Database (Denmark)

    Enemark, Stig

    2014-01-01

    Security of tenure is widely considered to be the missing piece of the puzzle when it comes to eradication of poverty. And, as explained in the previous issue of Geoinformatics, the European Union is now placing land rights at the heart of EU development policy. This article presents a way forwar...... in terms of building flexible and "fit-for-purpose" land administration systems in developing countries. This will ensure security of tenure for all and sustainable management of the use of land....

  5. Moodle administration essentials

    CERN Document Server

    Henrick, Gavin

    2015-01-01

    If you are an experienced system administrator and know how to manage servers and set up web environments but now want to explore Moodle, this book is perfect for you. You'll get to grips with the basics and learn to manage Moodle quickly, focusing on essential tasks. Having prior knowledge of virtual learning environments would be beneficial, but is not mandatory to make the most of this book.

  6. Views of collaboration among administrators and teachers involved in science education reform

    Science.gov (United States)

    Trax, Mark Francis

    The purposes of this study were to investigate the perceptions of collaboration among administrators and teachers involved in science education reform, determine similarities and difference in perception among administrators and teachers, and examine the progress of district reform efforts in terms of reform recommendations advanced in the research literature. Naturalistic constructivist theory guided the generation of the instruments and the analysis of data. Instruments for this investigation included a questionnaire and structured surveys. Audio-taped responses to the surveys were transcribed and analyzed for patterns of interaction. Support for science teacher collaboration and science education reform depended on the district's overall organizational style (classified as top-down, bottom-up, or a combination of these two styles), was connected to the level of commitment of the sciences teachers and administrators interviewed, and was linked to the level of solidarity for that support among teachers and administrators in the district. Reform-oriented districts addressed resource allocation in ways that supported science education reform. Science teachers, identified as the agents for educational reform, facilitated the overall process by providing specific evidence in support of reform, recruiting teachers and administrators to a reform-oriented agenda, and creating close-knit cadres engaged in the reform process. District activities in support of science education reforms which reflect the overall school reform recommendations maintained their focus provided that such activities were monitored and adjusted to furnish opportunities to include all the district science teachers, utilized a committed cadre of science teachers that supported the overall recommendations, and facilitated the inclusion of all district staff in the overall process. For success, it is important for the staff in each district to identify a clear need and establish a high level of

  7. Genesis of tax administration

    OpenAIRE

    Myskin, Y. I.

    2014-01-01

    The history of formation and development of tax administration is studied. The stages of genesis of tax administration are identified and described. The historically caused major trends in tax administration which are based on knowledge of the nature of causality are formulated. Досліджено історію становлення та розвитку управління оподаткуванням. Визначено та охарактеризовано етапи генезису управління оподаткуванням. На основі пізнання природи причинно-наслідкових зв’язків сфо...

  8. Evaluating administrative data quality as inputof the statistical production process

    OpenAIRE

    Fulvia Cerroni; Grazia Di Bella; Lorena Galiè

    2014-01-01

    Evaluating and reporting data quality of administrative sources is a growing need for National Statistical Institutes (NSIs) as more and more production processes are using this type of data source. To monitor the quality of the administrative data supply that enter the statistical production process, to evaluate its possible use for statistical purposes and to support administrative data acquisition are tasks that should be performed in the early stages of the production process. The paper r...

  9. 28 CFR 76.30 - Evidence.

    Science.gov (United States)

    2010-07-01

    ... be open to examination by all parties, unless otherwise ordered by the Judge pursuant to 28 CFR 76.27. ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Evidence. 76.30 Section 76.30 Judicial... POSSESSION OF CERTAIN CONTROLLED SUBSTANCES § 76.30 Evidence. (a) The Judge shall determine the...

  10. State Agency Administrative Boundaries

    Data.gov (United States)

    Kansas Data Access and Support Center — This database comprises 28 State agency boundaries and point of contact. The Kansas Geological Survey collected legal descriptions of the boundaries for various...

  11. 47 CFR 54.702 - Administrator's functions and responsibilities.

    Science.gov (United States)

    2010-10-01

    ... support mechanisms and administrative action intended to prevent waste, fraud, and abuse. The report also... separate accounts for the amounts of money collected and disbursed for eligible schools and...

  12. Job insecurity, job satisfaction, social support and general health of educators in the Sedibeng West Municipal District / Gertzen Schlemmer.

    OpenAIRE

    Schlemmer, Gertzen

    2009-01-01

    Education is recognised worldwide as one of the most stressful work environments. Contributing factors include poor remuneration, workload. poor administrative support. Poor relationships with colleagues and superiors. a lack of respect for the profession and few career advancement opportunities. The result is that a high number of educators experience negative physical and psychological symptoms. Evidence from research suggests that the level of burnout among educators is increasing. that e...

  13. Collaborating With Businesses to Support and Sustain Research.

    Science.gov (United States)

    Moch, Susan Diemert; Jansen, Debra A; Jadack, Rosemary A; Page, Phil; Topp, Robert

    2015-10-01

    Financial assistance is necessary for sustaining research at universities. Business collaborations are a potential means for obtaining these funds. To secure funding, understanding the process for obtaining these business funds is important for nursing faculty members. Although faculty rarely request funding from businesses, they are often in a position to solicit financial support due to existing relationships with clinical agency administrators, staff, and community leaders. The economic support received from businesses provides outcomes in nursing research, research education, academic-service partnerships, and client health care. This article describes the steps and processes involved in successfully obtaining research funding from businesses. In addition, case examples for securing and maintaining funding from health care agencies (evidence-based practice services) and from a health manufacturing company (product evaluation) are used to demonstrate the process. PMID:25869995

  14. 48 CFR 1419.505 - Rejecting Small Business Administration recommendations.

    Science.gov (United States)

    2010-10-01

    ... Rejecting Small Business Administration recommendations. (a) A written justification in support of the CO's... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Rejecting Small Business Administration recommendations. 1419.505 Section 1419.505 Federal Acquisition Regulations System DEPARTMENT...

  15. The Administrative Role in the Integration of Technology.

    Science.gov (United States)

    Ritchie, Donn

    1996-01-01

    Despite technologies' great potential for enhancing classroom instruction and school administration, most schools have yet to implement them beyond a basic level. There are several reasons for this reluctance, including lack of administrative support. Principals must reeducate themselves, procure necessary resources, understand technological…

  16. The Administration of Tax Systems

    OpenAIRE

    John Hasseldine

    2010-01-01

    This chapter analyses recent developments in tax administration and best practice. The chapter begins by contextualizing tax administration through a discussion on the necessary separation between the operational tasks performed in tax administration and the more generic, but nevertheless crucial, issues of organization, strategy and internal management required in tax administration. The chapter then describes the recent genesis and the current context of tax administration - especially in E...

  17. Judicial Control over Public Administration

    OpenAIRE

    Fadil ZENDELI; Memet MEMETI; Agron RUSTEMI

    2012-01-01

    Judicial control of administration and installation of courts as specialized institutions for resolving administrative disputes (conflicts) strengthened legitimacy, efficiency and accountability of the administrative bodies and this contributed to strengthening the protection of human rights against administrative bodies. The paper attempts to address the administrative disputes (conflict) in general hence giving specific data for some European countries and USA. Access to thesis topic is ana...

  18. Supportive Care.

    Science.gov (United States)

    Olsen, Pia Riis; Lorenzo, Rosalía

    2016-01-01

    This chapter takes its point of departure in psychosocial aspects of supportive care in adolescent and young adult cancer care. The purpose is to describe some of the challenges that these young people face following a cancer diagnosis and guide healthcare professionals in how to provide care that improves the quality of life. In most hospitals and healthcare systems, adolescents and young adults are cared for and treated in settings for children or adults. Accordingly, healthcare professionals may lack attention to and knowledge about what characterize young peoples' life situation, their special needs and how to meet them. The topics we include in the chapter are the following: the youth friendly environment, social support and social network, parents, information during a psychosocial crisis event, the use of HEADSS, peer support, fertility, body image and self-esteem, after treatment and future challenges and palliative and end of life care. PMID:27595353

  19. Supporting Teachers in Inclusive Education

    OpenAIRE

    Alekhina S.V.; Silanteva T.A.

    2015-01-01

    The article regards the issues of support provision to teachers involved in inclusive education as the main requirement for successful realization of inclusion. The methodological framework used in the study is a resource approach. The article describes the ways of extending the means of supporting teachers. The article also arguments for consolidating all the educators of inclusive schools into inclusive teams equally interested in joint work of administration and educators of intervention p...

  20. Supporting Teachers in Inclusive Education

    Directory of Open Access Journals (Sweden)

    Alekhina S.V.

    2015-03-01

    Full Text Available The article regards the issues of support provision to teachers involved in inclusive education as the main requirement for successful realization of inclusion. The methodological framework used in the study is a resource approach. The article describes the ways of extending the means of supporting teachers. The article also arguments for consolidating all the educators of inclusive schools into inclusive teams equally interested in joint work of administration and educators of intervention programs.