Determination of the radiation dose to the body due to external radiation

International Nuclear Information System (INIS)

Drexler, G.; Eckerl, H.

1985-01-01

Section 63 of the Radiation Protection Ordinance defines the basic requirement, determination of radiation dose to the body. The determination of dose equivalents for the body is the basic step in practical monitoring of dose equivalents or dose limits with regard to individuals or population groups, both for constant or varying conditions of exposure. The main field of monitoring activities is the protection of persons occupationally exposed to ionizing radiation. Conversion factors between body doses and radiation quantities are explained. (DG) [de

Report on administrative work at radiation safety center in fiscal year 2000

Energy Technology Data Exchange (ETDEWEB)

Uda, Tatsuhiko; Sakuma, Yoichi; Kawano, Takao; Yamanishi, Hirokuni; Shinotsuka, Kazunori; Asakura, Yamato; Miyake, Hitoshi

2002-05-01

National Institute for Fusion Science constructed Large Helical Device (LHD) which is the largest magnetic confinement plasma experimental device using super conductive magnet coils. It took eight years to construct and the first plasma shot had been carried out on March 1998. Since then plasma confinement experiments have been improved. This is the report of administrative work at the radiation safety center considering radiation protection for workers at the LHD and related devices, and radiation monitoring in the site. Major scope is as follows. (1) Radiation measurement and dose monitoring in the radiation controlled area and in the site using particularly developed monitoring system named as Radiation Monitoring System Applicable to Fusion Experiments (RMSAFE). (2) Establishment of education and registration system for radiation workers and access control system for the LHD controlled area. I hope that as like the published report of fiscal year 1999, the present report will be helpful for management of future radiation protection in the research institute. (author)

Report on administrative work at radiation safety center in fiscal year 2001

Energy Technology Data Exchange (ETDEWEB)

Uda, Tatsuhiko; Asakura, Yamato; Sakuma, Yoichi; Kawano, Takao; Yamanishi, Hirokuni; Sugiyama, Takahiko; Miyake, Hitoshi

2003-03-01

National Institute for Fusion Science constructed Large Helical Device (LHD) which is the largest magnetic confinement plasma experimental device using super conductive magnet coils. It took eight years to construct and the first plasma shot had been carried out on March 1998. In the experiments high plasma temperature and improved plasma confinement have been achieved. This is the report of administrative work at the radiation safety center considering radiation protection for workers at the LHD and related devices, and radiation monitoring in the site. Major scope is as follows. (1) Radiation measurement and dose monitoring in the radiation controlled area and in the site using particularly developed monitoring system named as Radiation Monitoring System Applicable to Fusion Experiments (RMSAFE). (2) Establishment of education and registration system for radiation workers and access control system for the LHD controlled area. I hope that as like the published reports of fiscal year 1999 and 2000, the present report will be helpful for management of future radiation protection in the research institute. (author)

Report on administrative work at radiation safety center in fiscal year 2003

International Nuclear Information System (INIS)

Uda, Tatsuhiko; Asakura, Yamato; Sakuma, Yoichi; Kawano, Takao; Yamanishi, Hirokuni; Sugiyama, Takahiko; Nishimura, Kiyohiko; Miyake, Hitoshi

2005-06-01

National Institute for Fusion Science constructed the Large Helical Device (LHD) which is the largest magnetic confinement plasma experimental device using super conductive magnet coils system. It took eight years to construct and the first plasma shot was carried out on March 1998. Since then high temperature plasma and improved plasma confinement experiments have been achieved. This is the report on administrative work at the radiation safety center considering radiation protection for workers at the LHD and the Compact Helical Device (CHS), and radiation measurement and monitoring in the site. Major scope is as follows. (1) Radiation (X ray) dose measurement and monitoring in the radiation controlled area and in the site using particularly developed monitoring system named as Radiation Monitoring System Applicable to Fusion Experiments (RMSAFE). (2) Establishment of education and registration system for radiation workers and accessing control system for the LHD controlled area. As same as the published annual reports from fiscal year 1999 to 2002, this report will be helpful for the future radiation safety management in the research institute. (author)

28 CFR 43.1 - Administrative determination and assertion of claims.

Science.gov (United States)

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Administrative determination and assertion of claims. 43.1 Section 43.1 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) RECOVERY OF COST OF HOSPITAL AND MEDICAL CARE AND TREATMENT FURNISHED BY THE UNITED STATES § 43.1 Administrative...

Report: Management Alert - Salary Increases for Certain Administratively Determined Positions

Science.gov (United States)

Report #18-N-0154, April 16, 2018. The purpose of this alert is to notify the EPA of certain factual info while our audit of the Office of the Administrator's (present and prior administrations) use of administratively determined positions continues.

Radiation therapy: model standards for determination of need

International Nuclear Information System (INIS)

Lagasse, L.G.; Devins, T.B.

1982-03-01

Contents: Health planning process; Health care requirements (model for projecting need for megavoltage radiation therapy); Operational objectives (manpower, megavoltage therapy and treatment planning equipment, support services, management and evaluation of patient care, organization and administration); Compliance with other standards imposed by law; Financial feasibility and capability; Reasonableness of expenditures and costs; Relative merit; Environmental impact

Medical Device Recalls in Radiation Oncology: Analysis of US Food and Drug Administration Data, 2002-2015.

Science.gov (United States)

Connor, Michael J; Tringale, Kathryn; Moiseenko, Vitali; Marshall, Deborah C; Moore, Kevin; Cervino, Laura; Atwood, Todd; Brown, Derek; Mundt, Arno J; Pawlicki, Todd; Recht, Abram; Hattangadi-Gluth, Jona A

2017-06-01

To analyze all recalls involving radiation oncology devices (RODs) from the US Food and Drug Administration (FDA)'s recall database, comparing these with non-radiation oncology device recalls to identify discipline-specific trends that may inform improvements in device safety. Recall data on RODs from 2002 to 2015 were sorted into 4 product categories (external beam, brachytherapy, planning systems, and simulation systems). Outcomes included determined cause of recall, recall class (severity), quantity in commerce, time until recall termination (date FDA determines recall is complete), and time since 510(k) approval. Descriptive statistics were performed with linear regression of time-series data. Results for RODs were compared with those for other devices by Pearson χ 2 test for categorical data and 2-sample Kolmogorov-Smirnov test for distributions. There were 502 ROD recalls and 9534 other class II device recalls during 2002 to 2015. Most recalls were for external beam devices (66.7%) and planning systems (22.9%), and recall events peaked in 2011. Radiation oncology devices differed significantly from other devices in all recall outcomes (P≤.04). Recall cause was commonly software related (49% vs 10% for other devices). Recall severity was more often moderate among RODs (97.6% vs 87.2%) instead of severe (0.2% vs 4.4%; Panalysis of recall data can identify areas for device improvement, such as better system design among RODs. Copyright © 2017 Elsevier Inc. All rights reserved.

Method and apparatus for determining accuracy of radiation measurements made in the presence of background radiation

International Nuclear Information System (INIS)

Horrocks, D.L.

1977-01-01

A radioactivity measuring instrument, and a method related to its use, for determining the radioactivity of a sample measured in the presence of significant background radiation, and for determining an error value relating to a specific probability of accuracy of the result are presented. Error values relating to the measurement of background radiation alone, and to the measurement of sample radiation and background radiation together, are combined to produce a true error value relating to the sample radiation alone

A case of severe rectal hemorrhage possibly caused by radiation recall after administration of gemcitabine

International Nuclear Information System (INIS)

Nishimoto, Koshiro; Akise, Yushi; Uchida, Atsushi; Miyazawa, Masaharu; Kutsuki, Shoji; Hashimoto, Subaru

2016-01-01

Radiation recall is an acute inflammatory reaction that can be triggered when systemic agents are administered long time after radiotherapy. Because radiotherapy is now indicated for many types of cancer, care should be taken regarding possible toxic events relating to radiotherapy in combination with radio-sensitizing agents. Gemcitabine, one such anti-cancer agent, is widely used, especially for urologic cancers. We report an intriguing case of possible radiation recall in the rectum caused by gemcitabine administration 37 years after radiation therapy. From a review of the literature, it appears that there have been no reported cases of radiation recall in the rectum with such a long interval between radiation therapy and chemotherapy. Here, we describe the case and provide a literature review. (author)

20 CFR 404.902 - Administrative actions that are initial determinations.

Science.gov (United States)

2010-04-01

... under a workmen's compensation law; (f) A deduction from your benefits on account of work; (g) [Reserved... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Administrative actions that are initial determinations. 404.902 Section 404.902 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL OLD-AGE...

12 CFR 709.8 - Administrative appeal of the initial determination.

Science.gov (United States)

2010-01-01

... must be in writing and must specify what type of appeal the claimant requests. The determination of... 12 Banks and Banking 6 2010-01-01 2010-01-01 false Administrative appeal of the initial... INVOLVING FEDERALLY INSURED CREDIT UNIONS IN LIQUIDATION § 709.8 Administrative appeal of the initial...

Medical Device Recalls in Radiation Oncology: Analysis of US Food and Drug Administration Data, 2002-2015

International Nuclear Information System (INIS)

Connor, Michael J.; Tringale, Kathryn; Moiseenko, Vitali; Marshall, Deborah C.; Moore, Kevin; Cervino, Laura; Atwood, Todd; Brown, Derek; Mundt, Arno J.; Pawlicki, Todd; Recht, Abram; Hattangadi-Gluth, Jona A.

2017-01-01

Purpose: To analyze all recalls involving radiation oncology devices (RODs) from the US Food and Drug Administration (FDA)'s recall database, comparing these with non–radiation oncology device recalls to identify discipline-specific trends that may inform improvements in device safety. Methods and Materials: Recall data on RODs from 2002 to 2015 were sorted into 4 product categories (external beam, brachytherapy, planning systems, and simulation systems). Outcomes included determined cause of recall, recall class (severity), quantity in commerce, time until recall termination (date FDA determines recall is complete), and time since 510(k) approval. Descriptive statistics were performed with linear regression of time-series data. Results for RODs were compared with those for other devices by Pearson χ"2 test for categorical data and 2-sample Kolmogorov-Smirnov test for distributions. Results: There were 502 ROD recalls and 9534 other class II device recalls during 2002 to 2015. Most recalls were for external beam devices (66.7%) and planning systems (22.9%), and recall events peaked in 2011. Radiation oncology devices differed significantly from other devices in all recall outcomes (P≤.04). Recall cause was commonly software related (49% vs 10% for other devices). Recall severity was more often moderate among RODs (97.6% vs 87.2%) instead of severe (0.2% vs 4.4%; P<.001). Time from 510(k) market approval to recall was shorter among RODs (P<.001) and progressively shortened over time. Radiation oncology devices had fewer recalled devices in commerce than other devices (P<.001). Conclusions: Compared with other class II devices, RODs experience recalls sooner after market approval and are trending sooner still. Most of these recalls were moderate in severity, and software issues are prevalent. Comprehensive analysis of recall data can identify areas for device improvement, such as better system design among RODs.

Medical Device Recalls in Radiation Oncology: Analysis of US Food and Drug Administration Data, 2002-2015

Energy Technology Data Exchange (ETDEWEB)

Connor, Michael J. [Department of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, California (United States); University of California Irvine School of Medicine, Irvine, California (United States); Tringale, Kathryn; Moiseenko, Vitali; Marshall, Deborah C.; Moore, Kevin; Cervino, Laura; Atwood, Todd; Brown, Derek; Mundt, Arno J.; Pawlicki, Todd [Department of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, California (United States); Recht, Abram [Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts (United States); Hattangadi-Gluth, Jona A., E-mail: jhattangadi@ucsd.edu [Department of Radiation Medicine and Applied Sciences, University of California, San Diego, La Jolla, California (United States)

2017-06-01

Purpose: To analyze all recalls involving radiation oncology devices (RODs) from the US Food and Drug Administration (FDA)'s recall database, comparing these with non–radiation oncology device recalls to identify discipline-specific trends that may inform improvements in device safety. Methods and Materials: Recall data on RODs from 2002 to 2015 were sorted into 4 product categories (external beam, brachytherapy, planning systems, and simulation systems). Outcomes included determined cause of recall, recall class (severity), quantity in commerce, time until recall termination (date FDA determines recall is complete), and time since 510(k) approval. Descriptive statistics were performed with linear regression of time-series data. Results for RODs were compared with those for other devices by Pearson χ{sup 2} test for categorical data and 2-sample Kolmogorov-Smirnov test for distributions. Results: There were 502 ROD recalls and 9534 other class II device recalls during 2002 to 2015. Most recalls were for external beam devices (66.7%) and planning systems (22.9%), and recall events peaked in 2011. Radiation oncology devices differed significantly from other devices in all recall outcomes (P≤.04). Recall cause was commonly software related (49% vs 10% for other devices). Recall severity was more often moderate among RODs (97.6% vs 87.2%) instead of severe (0.2% vs 4.4%; P<.001). Time from 510(k) market approval to recall was shorter among RODs (P<.001) and progressively shortened over time. Radiation oncology devices had fewer recalled devices in commerce than other devices (P<.001). Conclusions: Compared with other class II devices, RODs experience recalls sooner after market approval and are trending sooner still. Most of these recalls were moderate in severity, and software issues are prevalent. Comprehensive analysis of recall data can identify areas for device improvement, such as better system design among RODs.

Radon in the Workplace: the Occupational Safety and Health Administration (OSHA) Ionizing Radiation Standard.

Science.gov (United States)

Lewis, Robert K

2016-10-01

On 29 December 1970, the Occupational Safety and Health Act of 1970 established the Occupational Safety and Health Administration (OSHA). This article on OSHA, Title 29, Part 1910.1096 Ionizing Radiation standard was written to increase awareness of the employer, the workforce, state and federal governments, and those in the radon industry who perform radon testing and radon mitigation of the existence of these regulations, particularly the radon relevant aspect of the regulations. This review paper was also written to try to explain what can sometimes be complicated regulations. As the author works within the Radon Division of the Pennsylvania Department of Environmental Protection, Bureau of Radiation Protection, the exclusive focus of the article is on radon. The 1910.1096 standard obviously covers many other aspects of radiation and radiation safety in the work place.

20 CFR 410.610 - Administrative actions that are initial determinations.

Science.gov (United States)

2010-04-01

... determinations. 410.610 Section 410.610 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE...) Withdrawal of claim or cancellation of withdrawal request. When a request for withdrawal of a claim, or a request for cancellation of a “request for withdrawal” of a claim, is denied by the Administration, the...

Report on administrative work for radiation safety from April 2004 to March 2006

International Nuclear Information System (INIS)

Uda, Tatsuhiko; Asakura, Yamato; Nishimura, Kiyohiko; Kawano, Takao; Yamanishi, Hirokuni; Miyake, Hitoshi

2006-11-01

The National Institute for Fusion Science (NIFS) constructed the Large Helical Device (LHD) which is the largest magnetic confinement plasma experimental device using a super conducting magnet coils system. The first plasma shot was carried out in March 1998 after eight years of construction. Since then high temperature plasmas and improved plasma confinement experiments have been achieved. On 1st April 2004, NIFS became one of the research institutes which constitute National Institute of Natural Sciences. Since then the regulation system of safety, health and environmental management has been minorly changed. This is a report on administrative work for radiation safety at the LHD and the Compact Helical System (CHS), and radiation measurement and monitoring on the site from 1st April 2004 to 31st March 2006. Major topics are as follows. (1) Establishment of a radiation safety management system based on the law of occupational safety, health and environment. (2) Radiation dose measurement and monitoring in the radiation controlled area and on the site using a particularly developed monitoring system named Radiation Monitoring System Applicable to Fusion Experiments (RMSAFE). (3) Establishment of an education and registration system for radiation workers, and accessing control system for the LHD controlled area. This report has been annually published from fiscal year 1999. We expect that these reports could be helpful for future radiation safety management in NIFS. (author)

Frequency and determinants of drug administration errors in the intensive care unit

NARCIS (Netherlands)

van den Bemt, PMLA; Fijn, R; van der Voort, PHJ; Gossen, AA; Egberts, TCG; Brouwers, JRBJ

Objective., The study aimed to identify both the frequency and the determinants of drug administration errors in the intensive care unit. Design: Administration errors were detected by using the disguised-observation technique (observation of medication administrations by nurses, without revealing

Physical determinants of radiation sensitivity in bacterial spores

International Nuclear Information System (INIS)

Powers, E.L.

1982-01-01

Several factors modifying radiation sensitivity in dry bacterial spores are described and discussed. Vacuum inducing the loss of critical structural water, very low dose rates of radiation from which the cell may recover, radiations of high linear energy transfer, and the action of temperature over long periods of time on previously irradiated cells are recognized from extensive laboratory work as important in determining survival of spores exposed to low radiation doses at low temperatures for long periods of time. Some extensions of laboratory work are proposed

46 CFR 201.3 - Authentication of rules, orders, determinations and decisions of the Administration.

Science.gov (United States)

2010-10-01

... 46 Shipping 8 2010-10-01 2010-10-01 false Authentication of rules, orders, determinations and decisions of the Administration. 201.3 Section 201.3 Shipping MARITIME ADMINISTRATION, DEPARTMENT OF....3 Authentication of rules, orders, determinations and decisions of the Administration. All rules...

Ineffectiveness of anticoagulation in experimental radiation

International Nuclear Information System (INIS)

Roettinger, E.M.; Sedlacek, R.; Suit, H.D.

1975-01-01

A spontaneous mammary carcinoma, a methylcholanthrene induced fibrosarcoma, and a methylcholanthrene induced squamous carcinoma have been examined in syngeneic C3Hsub(f)/Sed mice to assess the modification of tumour response to local radiation therapy by the administration of warfarin. For the fibrosarcoma (demonstrably antigenic in this animal system) recipient mice were noraml or previously sensitized to the tumor. The transplant take rate and the growth rate of the mammary carcinoma and the fibrosarcoma were determined following subcutaneous injections of single cell suspensions. The radiation dose required for local control of 50% of the tumors (TCD 50 ) was determined for single and ten equal radiation doses. The dosage of warfarin in the drinking water resulted in a 2 to 3-fold prolongation of the prothrombin time. Warfarin administration before and following inoculation of tumor cells did not alter the transplantability. Warfarin administration either during the course of fractionated irradiation, or at and following single doses, did not affect tumor response to irradiation. (author)

Apparatus for radiation source depth determination in a material

International Nuclear Information System (INIS)

Campbell, P.J.

1979-01-01

An apparatus is disclosed for determining the depth of a radiation source within a body of material utilizing a radiation source holder moving the radiation source within the body. A plurality of switches have contacts that are fixed in relation to the movement of the radiation source within the material. Trigger means activates a particular switch at a preselected depth of the radiation source. Means for indicating the activation of a switch would thus produce a signal as a representative of the depth of the radiation source

New radiation mitigators to reduce bone marrow death of mice by post-irradiation administration

International Nuclear Information System (INIS)

Anzai, Kazunori

2009-01-01

We have found recently that heat-treated mineral yeast preparations and water-soluble analogs of vitamin E are potent radiation mitigator to reduce bone marrow death of mice by post-irradiation administration. When administered immediately after whole-body X-irradiation (7.5 Gy), both Zn-yeast and γ-tocopherol dimethylglycine ester (TDMG) significantly increased the viability of mice from 0% (control) to more than 90% (treated). Zn-yeast did not inhibit the tumor-regulation by γ-rays but even sensitize the radiation effect in mice xenografts of HeLa cells. (author)

Administration of the peroxisomal proliferator-activated receptor γ agonist pioglitazone during fractionated brain irradiation prevents radiation-induced cognitive impairment

International Nuclear Information System (INIS)

Zhao Weiling; Payne, Valerie; Tommasi, Ellen; Diz, Debra I.; Hsu, F.-C.; Robbins, Mike E.

2007-01-01

Purpose: We hypothesized that administration of the anti-inflammatory peroxisomal proliferator-activated receptor γ (PPARγ) agonist pioglitazone (Pio) to adult male rats would inhibit radiation-induced cognitive impairment. Methods and Materials: Young adult male F344 rats received one of the following: (1) fractionated whole brain irradiation (WBI); 40 or 45 Gy γ-rays in 4 or 4.5 weeks, respectively, two fractions per week and normal diet; (2) sham-irradiation and normal diet; (3) WBI plus Pio (120 ppm) before, during, and for 4 or 54 weeks postirradiation; (4) sham-irradiation plus Pio; or (5) WBI plus Pio starting 24h after completion of WBI. Results: Administration of Pio before, during, and for 4 or 54 weeks after WBI prevented Radiation-induced cognitive impairment. Administration of Pio for 54 weeks starting after completion of fractionated WBI substantially but not significantly reduced Radiation-induced cognitive impairment. Conclusions: These findings offer the promise of improving the quality of life and increasing the therapeutic window for brain tumor patients

Genotypic sex determination enabled adaptive radiations of extinct marine reptiles.

Science.gov (United States)

Organ, Chris L; Janes, Daniel E; Meade, Andrew; Pagel, Mark

2009-09-17

Adaptive radiations often follow the evolution of key traits, such as the origin of the amniotic egg and the subsequent radiation of terrestrial vertebrates. The mechanism by which a species determines the sex of its offspring has been linked to critical ecological and life-history traits but not to major adaptive radiations, in part because sex-determining mechanisms do not fossilize. Here we establish a previously unknown coevolutionary relationship in 94 amniote species between sex-determining mechanism and whether a species bears live young or lays eggs. We use that relationship to predict the sex-determining mechanism in three independent lineages of extinct Mesozoic marine reptiles (mosasaurs, sauropterygians and ichthyosaurs), each of which is known from fossils to have evolved live birth. Our results indicate that each lineage evolved genotypic sex determination before acquiring live birth. This enabled their pelagic radiations, where the relatively stable temperatures of the open ocean constrain temperature-dependent sex determination in amniote species. Freed from the need to move and nest on land, extreme physical adaptations to a pelagic lifestyle evolved in each group, such as the fluked tails, dorsal fins and wing-shaped limbs of ichthyosaurs. With the inclusion of ichthyosaurs, mosasaurs and sauropterygians, genotypic sex determination is present in all known fully pelagic amniote groups (sea snakes, sirenians and cetaceans), suggesting that this mode of sex determination and the subsequent evolution of live birth are key traits required for marine adaptive radiations in amniote lineages.

Radiation exposure and radiation protection of the physician in iodine-131 Lipiodol therapy of liver tumours

International Nuclear Information System (INIS)

Risse, J.H.; Ponath, C.; Palmedo, H.; Biersack, H.J.; Menzel, C.; Gruenwald, F.

2001-01-01

Intra-arterial iodine-131 labelled Lipiodol therapy for liver cancer has been investigated for safety and efficacy over a number of years, but data on radiation exposure of personnel have remained unavailable to date. The aim of this study was to assess the radiation exposure of the physician during intra-arterial 131 I-Lipiodol therapy for liver malignancies and to develop appropriate radiation protection measures and equipment. During 20 intra-arterial administrations of 131 I-Lipiodol (1110-1924 MBq), radiation dose equivalents (RDE) to the whole body, fingers and eyes of the physician were determined for (a) conventional manual administration through a shielded syringe, (b) administration with an automatic injector and (c) administration with a lead container developed in-house. Administration by syringe resulted in a finger RDE of 19.5 mSv, an eye RDE of 130-140 μSv, and a whole-body RDE of 108-119 μSv. The injector reduced the finger RDE to 5 mSv. With both technique (a) and technique (b), contamination of angiography materials was observed. The container allowed safe transport and administration of the radiopharmaceutical from 4 m distance and reduced the finger RDE to 131 I-Lipiodol was administered by syringe or injector, but was significantly reduced with the lead container. (orig.)

Protection from radiation injury through oral administration of PF4 gene carried by attenuated salmonella

International Nuclear Information System (INIS)

Zhao Lihua; Liu Bin; Yu Xiaofei; Zhang Lei; Han Zhongchao

2005-01-01

Objective: To investigate the in vivo radiation protection effect of PF4 by oral administration of attenuated salmonella as the carrier in mice. Methods: The eukaryotic vector pIRES2-EGFP-carried PF4 gene was transferred into an aroA-autotrophic mutant of salmonella typhimurium (SL3261), which was administered orally to BALBPc mice at 1x10 8 PFu once every interval three days. At 12 hours after the third oral administration the mice were subjected to a total body irradiation (TBI) of 700 cGy by a 60 Co source. The protective effect of SL3261/PF4 was determined by detection GFP ( green fluorescence protein) expression in tissues, peripheral blood count, culture of bone marrow colony-forming cells and survival time of mice. Results: Expression of GFP could be detected in the liver, spleen, intestine, kidney, peripheral blood and bone marrow. On days 7 and 14 after irradiation, Compared to controls, there were obvious differences in number of bone marrow mononuclear cells, CFU-GM (granulocyte-macrophage colony-forming unit ) and HPP-CFC (high proliferating potential-colony-forming cells) of mice treated with SL3261/PF4 (P<0.05) as well as prolongation of the survival time. Conclusion: These data demonstrate for the first time that PF4 protects mice from TBI injury and accelerates recovery of hematopoiesis by oral administration of attenuated salmonella carrying PF4 gene. (authors)

Determine Daytime Earth's Radiation Budget from DSCOVR

Science.gov (United States)

Su, W.; Thieman, M. M.; Duda, D. P.; Khlopenkov, K. V.; Liang, L.; Sun-Mack, S.; Minnis, P.; SUN, M.

2017-12-01

The Deep Space Climate Observatory (DSCOVR) platform provides a unique perspective for remote sensing of the Earth. With the National Institute of Standards and Technology Advanced Radiometer (NISTAR) and the Earth Polychromatic Imaging Camera (EPIC) onboard, it provides full-disk measurements of the broadband shortwave and total radiances reaching the L1 position. Because the satellite orbits around the L1 spot, it continuously observes a nearly full Earth, providing the potential to determine the daytime radiation budget of the globe at the top of the atmosphere. The NISTAR is a single-pixel instrument that measures the broadband radiance from the entire globe, while EPIC is a spectral imager with channels in the UV and visible ranges. The Level 1 NISTAR shortwave radiances are filtered radiances. To determine the daytime TOA shortwave and longwave radiative fluxes, the NISTAR measured shortwave radiances must be unfiltered first. We will describe the algorithm used to un-filter the shortwave radiances. These unfiltered NISTAR radiances are then converted to the full disk shortwave and daytime longwave fluxes, by accounting for the anisotropic characteristics of the Earth-reflected and emitted radiances. These anisotropy factors are determined by using the scene identifications determined from multiple low Earth orbit and geostationary satellites matched into the EPIC field of view. Time series of daytime radiation budget determined from NISTAR will be presented, and methodology of estimating the fluxes from the small unlit crescent of the Earth that comprises part of the field of view will also be described. The daytime shortwave and longwave fluxes from NISTAR will be compared with CERES dataset.

Enhancement of radiation effect on mouse intestinal crypt survival by timing of 5-fluorouracil administration

International Nuclear Information System (INIS)

Ho, E.; Coffey, C.; Maruyama, Y.

1977-01-01

There is a marked dependence of mouse crypt survival on the sequence of combined drug-radiation treatment and on the time lapse between irradiation and drug administration. When 5-fluorouracil is administered 6 hours after irradiation or later (up to 18 hours postirradiation), crypt survival drops significantly

Vessel used in radiation counting to determine radioactivity levels

International Nuclear Information System (INIS)

Charlton, J.C.; Glover, J.S.; Shephard, B.P.

1977-01-01

This invention concerns the vessels used in radiation counting to determine radioactivity levels. These vessels prove to be particularly useful in analyses of the kind where a radioactive element or compound is separated into two phases and the radioactivity of one phase is determined. Such a vessel used in the counting of radiation includes an organic plastic substance tube appreciably cylindrical in shape whose upper end is open whilst the lower end is closed and integral with it, and an anti-radiation shield in metal or in metal reinforced plastic located at the lower end of the tube and extending along the wall of the tube up to a given height. The vessel contains a reaction area of 1 to 10 ml for holding fluid reagents [fr

Radiation protection with mesalamine (5-amino salicylic acid)

International Nuclear Information System (INIS)

Onoda, James M.; Court, Wayne S.; Feldmeier, John J.; Alecu, Rodica

1996-01-01

Purpose: Radiation proctitis induced during the therapy of rectal and prostate cancers, and radiation injuries in general, are often the principal dose limiting factor limiting dose escalation for radiation therapy. Thus, there has been a continuous search for radioprotective agents, especially those that could selectively protect normal tissues, as opposed to the target cancer. 5-amino salicylic acid (5ASA) is in clinical use as Mesalamine for the local treatment of ulcerative proctitis. Inasmuch as other investigators have identified 5ASA as a free radical scavenger, we determined whether pretreatment with 5ASA could confer radiation protection. Materials and Methods: Adult male C57BL/6J mice obtained from Jackson Laboratories were employed for these studies. We determined LD50 for acute gastrointestinal death for young (≤ 10 weeks old, ≤ 25 gms body weight) and aged (≥ 1 year old, ≥ 35 gms body weight) animals exposed to single fractions (1 - 20 Gy) from three different radiation sources, Cs 137 , 270 KeV x-rays, and a 4 MeV linear accelerator. Experimental mice were pre- or post-treated with 5ASA in an acidified isotonic saline solution by oral, rectal, or intraperitoneal administration. Animals were housed, maintained by AAALAC standards and treated with antibiotics or acidified water post radiation exposure to control opportunistic infections. Animals were scored for death when moribund. Results: 5ASA was found to be radioprotective by oral, rectal or intraperitoneal administration when given 15 to 90 minutes prior to radiation exposure. Administration of drug following radiation exposure failed to confer radioprotection. We determined a dose effect for 5ASA with maximum tolerated dose of 200 mg/kg administered ip 30 minutes prior to 11 Gy whole body exposure. Dose modification and radioprotection by 5ASA were determined by LD50(6), LD50(30), or LD50(365). More recently, we determined that 5ASA conferred significant radioprotection to mice exposed to

The Evaluation of personnel radiation dose and society radiation on RSG-GAS around as proposal determination of ALARA value

International Nuclear Information System (INIS)

Pande Made Udiyani; Puradwi IW

2007-01-01

Each nuclear installation to achieve radiation safety has to meet the ALARA concepts. The ALARA value of a nuclear installation should be enacted by regulator body. ALARA value can be determined by evaluation radiation exposure and dose acceptance of nuclear installation operation. As case study in Indonesia, ALARA assessment in nuclear installation is done at RSG-GAS reactor. Intention of this research is to determine gyration reference assess ALARA by evaluate radiation dose acceptance by RSG-GAS radiation personnel and the influence of RSG-GAS operation to presentation of radiation accepted by society which living around its. ALARA of RSG-GAS determined based on evaluation of measurement data of the radiation doses which is accepted by personnel radiation. While evaluation of radiation doses which is accepted by society in the radius 5 km of the RSG-GAS conducted to data result of calculation using program package of CAP-88 and measurement result with method of carborne survey. Result of radiation dose evaluation obtained which not pass dose definition for the radiation worker that is 50 mSv/year, and for society around RSG-GAS that is 5 mSv/year. Based on the result of evaluation hence obtained value of ALARA for RSG-GAS in value of gyration 17 - 50 mSv/year. (author)

Sequential Administration of Carbon Nanotubes and Near Infrared Radiation for the Treatment of Gliomas

Directory of Open Access Journals (Sweden)

Tiago eSantos

2014-07-01

Full Text Available The objective was to use carbon nanotubes (CNT coupled with near infrared radiation (NIR to induce hyperthermia, as a novel non-ionizing radiation treatment for primary brain tumors, glioblastoma multiforme (GBM. In this study we report the therapeutic potential of hyperthermia-induced thermal ablation using the sequential administration of carbon nanotubes and NIR. In vitro studies were performed using glioma tumor cell lines (U251, U87, LN229, T98G. Glioma cells were incubated with CNTs for 24 hours followed by exposure to NIR for 10 minutes. Glioma cells preferentially internalized CNTs, which upon NIR exposure, generated heat, causing necrotic cell death. There were minimal effects to normal cells, which correlate to their minimal uptake of CNTs. Furthermore, this protocol caused cell death to glioma cancer stem cells, and drug-resistant as well as drug-sensitive glioma cells. This sequential hyperthermia therapy was effective in vivo, in the rodent tumor model resulting in tumor shrinkage and no recurrence after only one treatment. In conclusion, this sequence of selective CNT administration followed by NIR activation provides a new approach to the treatment of glioma, particularly drug-resistant gliomas.

Research into radiation protection. 1994 Programme report. Report on radiation departmental research programme on radiation protection, sponsored by the Federal Ministry for the Environment, Nature Conservation and Reactor Safety, and placed under the administrative and subject competence of the Federal Radiation Protection Office

International Nuclear Information System (INIS)

Goedde, R.; Schmitt-Hannig, A.; Thieme, M.

1994-10-01

On behalf of the Ministery for Environment, Nature Conservation and Nuclear Safety (BMU), the Federal Office for Radiation Protection is placing research and study contracts in the field of radiation protection. The results of these projects are used for developing radiation protection rules and to fulfill the special radiation protection tasks of the BMU, required by law. Planning, expert and administrative management, placing, assistance as well as expert evaluation of the results from these research projects lies within the responsibility of the Federal Office for Radiation Protection. This report provides information on preliminary and final results of radiation protection projects within the BMU Department Research Programme of the year 1994. (orig.) [de

Research into radiation protection. 1995 Programme report. Report on radiation departmental research programme on radiation protection, sponsored by the Federal Ministry for the Environment, Nature Conservation and Reactor Safety, and placed under the administrative and subject competence of the Federal Radiation Protection Office

International Nuclear Information System (INIS)

Thieme, M.; Goedde, R.; Schmitt-Hannig, A.

1996-01-01

On behalf of the Ministry for Environment, Nature Conservation and Nuclear Safety (BMU), the Federal Office for Radiation Protection is placing research and study contracts in the field of radiation protection. The results of these projects are used for developing radiation protection rules and to fulfill the special radiation protection tasks of the BMU, required by law. Planning, expert and administrative management, placing, assistance as well as expert evaluation of the results from these research projects lies within the responsibility of the Federal Office for Radiation Protection. This report provides information on preliminary and final results of radiation protection projects within the BMU Department Research Programme of the year 1995. (orig.) [de

24 CFR 17.153 - Determination of the Administrative Judge.

Science.gov (United States)

2010-04-01

... Administrative Judge shall issue a written decision which includes the supporting rationale for the decision. The... Department, the Department's Office of Finance and Accounting, the debtor, and the debtor's attorney or other... determination is received by the Department's Chief Financial Officer. No referral will be made to the IRS or...

Determinants of the administration of continuous palliative sedation: a systematic review.

Science.gov (United States)

van Deijck, Rogier H P D; Hasselaar, Jeroen G J; Verhagen, Stans C A H H V M; Vissers, Kris C P; Koopmans, Raymond T C M

2013-12-01

Little is known about the determining factors related to the administration of continuous palliative sedation. Knowledge of these determinants may assist physicians in identifying patients who are at high risk of developing refractory symptoms, enable physicians to inform patients, and optimize close monitoring. The aim of this systematic review was to identify determinants of the administration of continuous palliative sedation. A systematic review of PubMed, EMBASE, and CINAHL was performed to identify English, Dutch, and German language papers published from January 1990 through April 2011. Inclusion was based on the following criteria: patient-based research on continuous palliative sedation, studies investigating determinants of palliative sedation and/or comparison between sedated and nonsedated cohorts, and studies using multivariate analyses and of fair to good or good methodological quality. In total, eight papers were reviewed. The following nine factors were found to be associated with the administration of continuous palliative sedation: younger age, male sex, having cancer, feelings of hopelessness, dying in a hospital, living in a Dutch speaking community setting, very nonreligious or extremely nonreligious physicians, physicians working in "other hospital" specialties, and physicians in favor of assisted death. Given the variation in study designs and the limitations of the included studies, the outcomes should be interpreted carefully. Further research is needed, particularly regarding factors that can be influenced and that may alter the course of a patient's symptoms and the patient's eventual need for palliative sedation.

Radioprotective efficacy of dipyridamole and AMP combination in fractionated radiation regimen, and its dependence on the time of administration of the drugs prior to irradiation

International Nuclear Information System (INIS)

Hofer, M.; Pospisil, M.; Netikova, J.; Hola, J.; Znojil, V.; Vacha, J.

1995-01-01

The authors have recently demonstrated that a combined administration of dipyridamole and adenosine monophosphate to mice induces radioprotective effects in terms of postirradiation hematopoietic recovery in animals irradiated with a single dose. The aim of the present experiments was to investigate the radioprotective ability of the drug combination under conditions of fractionated radiation. It was shown that administration of the drugs either 15 or 60 min before each of the five daily 3-Gy doses of gamma radiation enhances hematopoietic recovery and survival of mice exposed to an additional 'top-up' dose of 3.5 Gy. Furthermore, it was ascertained that administration of the drugs 60 min prior to irradiation is more effective than administration of the drugs 15 min prior to irradiation. Due to the evidence that administration of the drugs 15 min prior to irradiation protects the organism mainly via mechanisms of systemic hypoxia while the pretreatment 60 min before irradiation avoids the role of hypoxia and mainly induces cell proliferation effects, the present results suggest a more protective role of mechanisms stimulating hematopoiesis under conditions of fractionated radiation. The data may provide a basis for more rational use of radioprotection in fractionated radiation techniques. (author) 1 tab., 1 fig., 25 refs

Toxic properties of specific radiation determinant molecules, derived from radiated species

Science.gov (United States)

Popov, Dmitri; Maliev, Vecheslav; Kedar, Prasad; Casey, Rachael; Jones, Jeffrey

Introduction: High doses of radiation induce the formation of radiation toxins in the organs of irradiated mammals. After whole body irradiation, cellular macromolecules and cell walls are damaged as a result of long-lived radiation-induced free radicals, reactive oxygen species, and fast, charged particles of radiation. High doses of radiation induce breaks in the chemical bonds of macromolecules and cross-linking reactions via chemically active processes. These processes result in the creation of novel modified macromolecules that possess specific toxic and antigenic properties defined by the type and dose of irradiation by which they are generated. Radiation toxins isolated from the lymph of irradiated animals are classified as hematotoxic, neurotoxic, and enteric non-bacterial (GI) radiation toxins, and they play an important role in the development of hematopoietic, cerebrovascular, and gastrointestinal acute radiation syndromes (ARS). Seven distinct toxins derived from post-irradiated animals have been designated as Specific Radiation Determinants (SRD): SRD-1 (neurotoxic radiation toxin generated by the cerebrovascular form of ARS), SRD-3 (enteric non-bacterial radiation toxins generated by the gastrointestinal form of ARS), and SRD-4 (hematotoxic radiation toxins generated by the hematological, bone marrow form of ARS). SRD-4 is further subdivided into four groups depending on the severity of the ARS induced: SRD-4/1, mild ARS; SRD-4/2, moderate ARS; SRD-4/3, severe ARS; and SRD-4/4, extremely severe ARS. The seventh SRD, SRD-2 is a toxic extract derived from animals suffering from a fourth form of ARS, as described in European literature and produces toxicity primarily in the autonimic nervous system. These radiation toxins have been shown to be responsible for the induction of important pathophysiological, immunological, and biochemical reactions in ARS. Materials and Methods: These studies incorporated the use of statistically significant numbers of a

The protective effect of lycopene against radiation injury to the small intestine of abdominally radiated mice

International Nuclear Information System (INIS)

Itoh, Youko; Kurabe, Teruhisa; Ishiguchi, Tsuneo

2004-01-01

To reduce the side effects of radiotherapy, radioprotective effects of lycopene on villi and crypts in the small intestine of abdominally radiated mice (15 Gy) were examined with administration pre-, continuous and post-radiation. In the lycopene group, the ratio of the villus length to the crypt was significantly increased in comparison with the radiation only group at 2 days after radiation. At 7 days after radiation, the ratio of necrotic cells in crypt/total was significantly decreased and the ratio of necrotic cells in villus/total was significantly increased by lycopene administration, which indicated an acceleration of the recovery from the radiation injury with lycopene. Each lycopene administered group showed a significant radioprotective effect, with the pre-radiation administration inducing a smaller effect than that of continuous and post-radiation administration. Radiation induced apoptosis was also decreased by lycopene administration. It is concluded that pre-, continuous and post-radiation administration of lycopene protects against radiation injury of the small intestine and accelerate the recovery. (author)

Determination of radiation direction in environmental monitoring

International Nuclear Information System (INIS)

Campos, Vicente de Paulo de; Moura, Eduardo S.; Rocha, Felicia D.G.; Manzoli, Jose Eduardo

2009-01-01

The assessment of environmental exposure has been performed in Brazil using the thermoluminescence technique at Thermoluminescence Dosimetry Laboratory (LDT), at Nuclear and Energetic Research Institute (IPEN/CNEN-SP). To carry out these measurements, several thermoluminescent dosimeters (TLD's) were used to measure the expose. In this procedure, very few information of direction where the radiation came from is available. A vague supposition about the direction from where the radiation came from could be inferred only by evaluation of multiple dosimeters displaced at entire region of monitoring, but this demand to much effort or sometimes become impractical for certain situations. In this work, a single device is used to provide information about the direction from where the radiation came through. This device is called directional dosimeter (DD). Using more than one DD it is possible to reduce the uncertainty of the measurements and determine the radiation source position. The DD basically consists of a regular solid with high effective atomic number, where one TLD is positioned at each face. The DD allows evaluating the environmental exposure and the direction of the radiation by a simple vector sum. At each face of the DD, it is associated an orthogonal vector, and modulus of this vector represents the correspond exposure measured by the TLD. The direction of the radiation source is the sum of these faces vectors. The prototype used in this work was a lead cube with six TLDs of CaSO 4 :Dy/Teflon. The TLDs have high sensibility and are already used in area, environmental and personal monitoring. The measurements had shown the correct environmental exposure and a good indication of the radiation direction. (author)

Timing of pilocarpine treatment during head and neck radiotherapy: concomitant administration reduces xerostomia better than post-radiation pilocarpine

International Nuclear Information System (INIS)

Zimmerman, Robert P.; Mark, Rufus J.; Juillard, Guy F.

1996-01-01

Purpose: To study whether oral pilocarpine administration during and three months after head and neck radiotherapy can prevent or reduce the expected post-radiation xerostomia. This regimen was compared to no treatment and to post-radiotherapy pilocarpine administration, which has previously been shown to reduce symptoms of xerostomia in several randomized trials. Methods: Xerostomia assessments were performed using a visual analog scale xerostomia questionnaire that measures oral dryness, oral comfort, difficulty with sleep, speech and eating. Higher scores indicate less xerostomia. All the patients had all major salivary glands in the initial field treated to ≥ 4,500 cGy. The concomitant pilocarpine group received 5 mg pilocarpine q.i.d. beginning on day one of radiotherapy and continuing for 3 months after completion of radiation. The control group had their baseline xerostomia measured prior to receiving pilocarpine. They subsequently took 5 mg pilocarpine t.i.d. for one month at which time they underwent a second xerostomia assessment. Xerostomia scores for each group were averaged and compared using the Student's t-test. Results: Seventeen patients who received pilocarpine during head and neck irradiation were compared to 12 post-radiotherapy patients who had not yet taken pilocarpine and the same patients after taking pilocarpine for one month. The mean intervals between completion of radiation and evaluation of xerostomia were 16 months for the control group and 17 months for the pilocarpine treated groups. The primary tumor sites treated as well as the total tumor doses were equivalent between the groups. Only one of the pilocarpine treated patients was still taking pilocarpine at the time of evaluation. Results are shown. For each component of xerostomia measured as well as the composite of all components, the group that had received pilocarpine during radiation had significantly less xerostomia than the no pilocarpine group (p<0.01 for each). Post

Determination of some radiative view factors

International Nuclear Information System (INIS)

Ghosh, B.; Mukhopadhyay, D.; Lele, H.G.; Fichot, F.; Guillard, G.

2011-01-01

View factors are essential components for analysis for of radiative heat transfer through enclosure methods like radiosity approach, direct/total exchange area approach etc. View factor is defined as the integral over the interacting surface. View factor integral can be calculated by following various approaches, such as: view factor algebra, direction analytical approach, contour integration method, Monte Carlo method, numerical methods based of FDM or FEM, Hottle's string method etc. The present module of work on determination of view factor is aimed for use in ASTEC code system for severe accident analysis. There exist many routines (RADB, RADC, GRADEB, RADR, RADL) in the ICARE module of ASTEC code system to model radiative heat transfer from different types of assemblies of interacting surfaces of different nature. The present work is specially targeted for radiative heat transfer model for lower plenum (RADILOWE) and for extension of ICARE module for IPHWR. In interacting surfaces within the lower plenum comprises of different types of circular, cylindrical and conical surface. In the work completed so far, view factor relations have been derived/compiled based on exact/approximate analytical and numerical approaches. (author)

Evaluation of occupational radiation dose in nuclear medicine: radiopharmaceutical administration to scintiscanning exams of myocardial perfusion

International Nuclear Information System (INIS)

Komatsu, Cassio V.; Michelin, Charlie A.; Jakubiak, Rosangela R.; Lemes, Alyne O.; Silva, Juliana L.M.

2013-01-01

In nuclear medicine, workers directly involved in exams are constantly exposed to ionizing radiation. The procedure for administration of the radiopharmaceutical to the patient is one of the most critical times of exposure. In tests of myocardial perfusion scintigraphy (MPS) administration of radiopharmaceutical repeats the steps of rest and cardiac stress. In this study, we used a Geiger -Mueller detector for measuring occupational radiation doses for during the administration of technetium- 99m - sestamibi in MPS tests. In the evaluation, discriminated the stages of examination and related professional experience time to doses measures at home. It were followed 110 procedures at home (55 conducted by professionals with over 5 years experience and 55 conducted by professionals with less than 1 year of experience) and 55 effort procedures. The results showed that the rest of the procedure time and dose are related to the experience of the worker. More experienced workers were faster (mean: 43 ± 16 vs 67 ± 25 seconds / procedure), and therefore received lower doses (mean 0.57 ± 0.16 versus 0.80 ± 0.24 μSv / procedure), both with statistical significance (p <0.001). In step effort, there were procedures lasting longer (mean: 19 ± 2 minutes / procedure), which resulted in higher doses (mean 3.0 ± 0.6 μSv / procedure)

Administration of radioisotope production

Energy Technology Data Exchange (ETDEWEB)

NONE

1964-01-15

Current developments in atomic energy, and the administrative problems to which they give rise, were surveyed in a seminar on 'Atomic Energy for Atomic Energy Administrators' held at IAEA headquarters from 30 September to 4 October 1963. The ground covered included protection against radiation, isotopes and radiation sources, research reactors, nuclear power, legal matters, technical and scientific administration, the role of the universities, and the Agency's part in assistance to developing countries. The possibilities and limitations of radioisotope production from research reactors were discussed by Dr. G. B. Cook, of the Division of Research and Laboratories, IAEA in this paper.

Administration of radioisotope production

International Nuclear Information System (INIS)

1964-01-01

Current developments in atomic energy, and the administrative problems to which they give rise, were surveyed in a seminar on 'Atomic Energy for Atomic Energy Administrators' held at IAEA headquarters from 30 September to 4 October 1963. The ground covered included protection against radiation, isotopes and radiation sources, research reactors, nuclear power, legal matters, technical and scientific administration, the role of the universities, and the Agency's part in assistance to developing countries. The possibilities and limitations of radioisotope production from research reactors were discussed by Dr. G. B. Cook, of the Division of Research and Laboratories, IAEA in this paper.

Determination of circumsolar radiation from Meteosat Second Generation

Science.gov (United States)

Reinhardt, B.; Buras, R.; Bugliaro, L.; Wilbert, S.; Mayer, B.

2014-03-01

Reliable data on circumsolar radiation, which is caused by scattering of sunlight by cloud or aerosol particles, is becoming more and more important for the resource assessment and design of concentrating solar technologies (CSTs). However, measuring circumsolar radiation is demanding and only very limited data sets are available. As a step to bridge this gap, a method was developed which allows for determination of circumsolar radiation from cirrus cloud properties retrieved by the geostationary satellites of the Meteosat Second Generation (MSG) family. The method takes output from the COCS algorithm to generate a cirrus mask from MSG data and then uses the retrieval algorithm APICS to obtain the optical thickness and the effective radius of the detected cirrus, which in turn are used to determine the circumsolar radiation from a pre-calculated look-up table. The look-up table was generated from extensive calculations using a specifically adjusted version of the Monte Carlo radiative transfer model MYSTIC and by developing a fast yet precise parameterization. APICS was also improved such that it determines the surface albedo, which is needed for the cloud property retrieval, in a self-consistent way instead of using external data. Furthermore, it was extended to consider new ice particle shapes to allow for an uncertainty analysis concerning this parameter. We found that the nescience of the ice particle shape leads to an uncertainty of up to 50%. A validation with 1 yr of ground-based measurements shows, however, that the frequency distribution of the circumsolar radiation can be well characterized with typical ice particle shape mixtures, which feature either smooth or severely roughened particle surfaces. However, when comparing instantaneous values, timing and amplitude errors become evident. For the circumsolar ratio (CSR) this is reflected in a mean absolute deviation (MAD) of 0.11 for both employed particle shape mixtures, and a bias of 4 and 11%, for the

The reduction of radiation damage to the spinal cord by post-irradiation administration of vasoactive drugs

International Nuclear Information System (INIS)

Hornsey, S.; Myers, R.; Jenkinson, T.

1990-01-01

Radiation induced white matter necrosis in the rat spinal cord is preceded by changes in permeability of the blood brain-barrier, reduced blood flow, and infarction so that the necrosis is an ischemic necrosis. Attempts have been made to modify this developing pathology by the administration of drugs post-irradiation but just prior to the changes in vascular permeability. Verapamyl, a calcium channel blocker, had no effect on the development of ataxia. Dipyridamole, a drug which increases blood flow and reduces thrombosis, delayed and reduced the onset of ataxia. A low iron diet and desferrioxamine which reduces reperfusion injury also delayed and reduced ataxia. These results support the thesis that vascular changes are an important pathway in the development of radiation necrosis and that reperfusion injury is an important factor in the development and exacerbation of radiation damage to the spinal cord

Spatial distribution of coefficients for determination of global radiation in Serbia

Directory of Open Access Journals (Sweden)

Nikolić Jugoslav L.

2012-01-01

Full Text Available The aim of this paper is a creation of the spatial distribution of the corresponding coefficients for the indirect determination of global radiation using all direct measurements data of this shortwave radiation balance component in Serbia in the standard climate period (1961-1990. Based on the global radiation direct measurements data recorded in the past and routine measurements/observations of cloudiness and sunshine duration, the spatial distribution coefficients maps required for calculation of global radiation were produced on the basis of sunshine/cloudiness in an arbitrary point on the territory of Serbia. Besides, a specific verification of the proposed empirical formula was performed. This paper contributes to a wide range of practical applications as direct measurements of global radiation are relatively rare, and are not carried out in Serbia today. Significant application is possible in the domain of renewable energy sources. The development of method for determination of the global radiation has an importance from the aspect of the environmental protection; however it also has an economic importance through applications in numerous commercial projects, as it does not require special measurements or additional financial investments.

Can short-term administration of dexamethasone abrogate radiation-induced acute cytokine gene response in lung and modify subsequent molecular responses?

International Nuclear Information System (INIS)

Hong, J.-H.; Chiang, C.-S.; Tsao, C.-Y.; Lin, P.-Y.; Wu, C.-J.; McBride, William H.

2001-01-01

Purpose: To investigate the effects of short-term administration of dexamethasone (DEX) on radiation-induced responses in the mouse lung, focusing on expression of pro-inflammatory cytokine and related genes. Methods and Materials: At indicated times after thoracic irradiation and/or drug treatment, mRNA expression levels of cytokines (mTNF-α, mIL-1α, mIL-1β, mIL-2, mIL-3, mIL-4, mIL-5, mIL-6, mIFN-γ) and related genes in the lungs of C3H/HeN mice were measured by RNase protection assay. Results: Radiation-induced pro-inflammatory cytokine mRNA expression levels in lung peak at 6 h after thoracic irradiation. DEX (5 mg/kg) suppresses both basal cytokine mRNA levels and this early response when given immediately after irradiation. However, by 24 h, in mice treated with DEX alone or DEX plus radiation, there was a strong rebound effect that lasted up to 3 days. Modification of the early radiation-induced response by DEX did not change the second wave of cytokine gene expression in the lung that occurs at 1 to 2 weeks, suggesting that early cytokine gene induction might not determine subsequent molecular events. A single dose of DEX attenuated, but did not completely suppress, increases in cytokine mRNA levels induced by lipopolysaccharide (2.5 mg/kg) treatment, but, unlike with radiation, no significant rebound effect was seen. Five days of dexamethasone treatment in the pneumonitic phase also inhibited pro-inflammatory cytokine gene expression and, again, there was a rebound effect after withdrawal of the drug. Conclusions: Our findings suggest that short-term use of dexamethasone can temporarily suppress radiation-induced pro-inflammatory cytokine gene expression, but there may be a rebound after drug withdrawal and the drug does little to change the essence and course of the pneumonitic process

Determination of the dose and dose distribution in radiation-linked polyolefins

International Nuclear Information System (INIS)

Andress, B.; Fischer, P.; Repp, H.H.; Roehl, P.

1984-01-01

The method serves the determination of the radiation dose and dose distribution in polyolefins cross-linked by electron beams; the cross-linking takes place in the presence of an additive which is inserted in the polyolefin by radiation. After the cross-linking the fraction of the additive which is not inserted will be extracted from the polyolefin and afterwards the total extinction of the polyolefin will be determined by photometry. This process allows in particular the determination of the quality of the irradiation conditions for the electron-beam cross-linking of medium-voltage cables insulated by polyolefins. (orig.) [de

Radiological and administrative criteria and procedures required by the Radiation Protection Ordinance for exemption from regulatory control

International Nuclear Information System (INIS)

Birkholz, W.

2000-01-01

The system of required radioactivity measurements and limits as well as methods, based on the 10 μSv concept, constitutes the regulatory regime for exemption of radioactive waste materials from regulatory control according to atomic energy law. The methods and administrative procedures are suitable both for smaller amounts of materials, such as those resulting from the use of radioactive substances in scientific research and medical applications, and for the large waste volumes emanating from the dismantling of nuclear installations. The system provided for in the Radiation Protection Ordinance ensures harmonized administrative action of all public authorities involved. (orig./CB) [de

Radiation dosimetry for bolus administration of oxygen-15-water

International Nuclear Information System (INIS)

Brihaye, C.; Depresseux, J.C.; Comar, D.

1995-01-01

The authors describe the development of a biokinetic model which permits an estimation of organ activities and the dosimetry of a bolus of 15 O-water. The aim of this study was to estimate time-activity functions and deduce the cumulated activities in different organs so that the radiation absorbed dose values can be estimated. The model used includes the right heart chambers, lungs, left heart chambers, brain, liver, kidneys, muscles, gasrointestinal tract and the remainder of the body. Activity in an organ will decay by physical decay with the decay constant, γ, and can diffuse in the organ. An exception is the heart, where blood is ejected from the heart chambers. Depending on the location of the organ in relation to the blood sampling point, organ activities can be calculated by convolution or deconvolution. The radiation absorbed dose values were estimated and an effective dose equivalent H E of 1.16 μSv/MBq (4.32 mrem/mCi) as well as an effective dose E of 1.15 μSv/MBq (4.25 mrem/mCi) were calculated. The cumulated activities in select organs measured by PET gave good agreement with the values calculated by this model. The values of effective dose equivalent and effective dose for bolus administration of 15 O-water calculated from the absorbed doses estimated by the proposed kinetic model are almost three times higher than those previously published. A total of 8700 MBq (235 mCi) of 15 O-water can be administered if an effective dose of 10 mSv (1 rem) is accepted. 32 refs., 5 figs., 2 tabs

Low-Dose Radiation Cataract and Genetic Determinants of Radiosensitivity

Energy Technology Data Exchange (ETDEWEB)

Kleiman, Norman Jay [Columbia University

2013-11-30

The lens of the eye is one of the most radiosensitive tissues in the body. Ocular ionizing radiation exposure results in characteristic, dose related, progressive lens changes leading to cataract formation. While initial, early stages of lens opacification may not cause visual disability, the severity of such changes progressively increases with dose until vision is impaired and cataract extraction surgery may be required. Because of the transparency of the eye, radiation induced lens changes can easily be followed non-invasively over time. Thus, the lens provides a unique model system in which to study the effects of low dose ionizing radiation exposure in a complex, highly organized tissue. Despite this observation, considerable uncertainties remain surrounding the relationship between dose and risk of developing radiation cataract. For example, a growing number of human epidemiological findings suggest significant risk among various groups of occupationally and accidentally exposed individuals and confidence intervals that include zero dose. Nevertheless, questions remain concerning the relationship between lens opacities, visual disability, clinical cataract, threshold dose and/or the role of genetics in determining radiosensitivity. Experimentally, the response of the rodent eye to radiation is quite similar to that in humans and thus animal studies are well suited to examine the relationship between radiation exposure, genetic determinants of radiosensitivity and cataractogenesis. The current work has expanded our knowledge of the low-dose effects of X-irradiation or high-LET heavy ion exposure on timing and progression of radiation cataract and has provided new information on the genetic, molecular, biochemical and cell biological features which contribute to this pathology. Furthermore, findings have indicated that single and/or multiple haploinsufficiency for various genes involved in DNA repair and cell cycle checkpoint control, such as Atm, Brca1 or Rad9

Problems of organization of interaction of administrative bodies and the forces engaged in liquidation of after-effects of radiation accident

International Nuclear Information System (INIS)

Popov, A.P.; Perevezentsev, A.M.

1995-01-01

The paper defines the main problems arising in connection with organization of interaction of the administrative bodies and the forces involved in liquidation of after-effects of radiation accident. It is demonstrated that in order to increase the efficiency of interaction of the administrative bodies of various levels it is necessary to make it automatic. The paper revealed the meaning of the levels of relationship between various automatic systems. 4 refs

Radiation safety

International Nuclear Information System (INIS)

Jain, Priyanka

2014-01-01

The use of radiation sources is a privilege; in order to retain the privilege, all persons who use sources of radiation must follow policies and procedures for their safe and legal use. The purpose of this poster is to describe the policies and procedures of the Radiation Protection Program. Specific conditions of radiation safety require the establishment of peer committees to evaluate proposals for the use of radionuclides, the appointment of a radiation safety officer, and the implementation of a radiation safety program. In addition, the University and Medical Centre administrations have determined that the use of radiation producing machines and non-ionizing radiation sources shall be included in the radiation safety program. These Radiation Safety policies are intended to ensure that such use is in accordance with applicable State and Federal regulations and accepted standards as directed towards the protection of health and the minimization of hazard to life or property. It is the policy that all activities involving ionizing radiation or radiation emitting devices be conducted so as to keep hazards from radiation to a minimum. Persons involved in these activities are expected to comply fully with the Canadian Nuclear Safety Act and all it. The risk of prosecution by the Department of Health and Community Services exists if compliance with all applicable legislation is not fulfilled. (author)

Experimental determination of radiated internal wave power without pressure field data

OpenAIRE

Lee, Frank M.; Paoletti, M. S.; Swinney, Harry L.; Morrison, P. J.

2014-01-01

We present a method to determine, using only velocity field data, the time-averaged energy flux $\\left$ and total radiated power $P$ for two-dimensional internal gravity waves. Both $\\left$ and $P$ are determined from expressions involving only a scalar function, the stream function $\\psi$. We test the method using data from a direct numerical simulation for tidal flow of a stratified fluid past a knife edge. The results for the radiated internal wave power given by the stream function method...

Comprehensive Review of Ultraviolet Radiation and the Current Status on Sunscreens

Science.gov (United States)

Moon, Summer; Armstrong, Frank

2012-01-01

In the past, manufacturers’ labeling of sunscreen varied greatly, confusing the consumers regarding efficacy and the appropriate photoprotection provided by their products. Therefore, in June 2011, the United States Food and Drug Administration issued new guidelines for sunscreen labeling. Sunscreen products are over-the-counter drugs; therefore, they are regulated by the United States Food and Drug Administration to determine safety, efficacy, and labeling. This article discusses ultraviolet radiation and the positive and negative effects of ultraviolet radiation, provides a review of sunscreens, and discusses the new United States Food and Drug Administration regulations for sunscreens. PMID:23050030

Problems in radiation absorbed dose estimation from positron emitters

International Nuclear Information System (INIS)

Powell, G.F.; Harper, P.V.; Reft, C.S.; Chen, C.T.; Lathrop, K.A.

1986-01-01

The positron emitters commonly used in clinical imaging studies for the most part are short-lived, so that when they are distributed in the body the radiation absorbed dose is low even though most of the energy absorbed is from the positrons themselves rather than the annihilation radiation. These considerations do not apply to the administration pathway for a radiopharmaceutical where the activity may be highly concentrated for a brief period rather than distributed in the body. Thus, high local radiation absorbed doses to the vein for an intravenous administration and to the upper airways during administration by inhalation can be expected. For these geometries, beta point source functions (FPS's) have been employed to estimate the radiation absorbed dose in the present study. Physiologic measurements were done to determine other exposure parameters for intravenous administration of O-15 and Rb-82 and for administration of O-15-CO 2 by continuous breathing. Using FPS's to calculate dose rates to the vein wall from O-15 and Rb-82 injected into a vein having an internal radius of 1.5 mm yielded dose rates of 0.51 and 0.46 (rad x g/μCi x h), respectively. The dose gradient in the vein wall and surrounding tissues was also determined using FPS's. Administration of O-15-CO 2 by continuous breathing was also investigated. Using ultra-thin thermoluninescent dosimeters (TLD's) having the effective thickness of normal tracheal mucosa, experiments were performed in which 6 dosimeters were exposed to known concentrations of O-15 positrons in a hemicylindrical tracheal phantom having an internal radius of 0.96 cm and an effective length of 14 cm. The dose rate for these conditions was 3.4 (rads/h)/(μCi/cm 3 ). 15 references, 7 figures, 6 tables

Interstitial administration of perfluorochemical emulsions for reoxygenation of hypoxic tumor cells

International Nuclear Information System (INIS)

Woo, D.V.; Seegenschmiedt, H.; Schweighardt, F.K.; Emrich, J.; McGarvey, K.; Caridi, M.; Brady, L.W.

1987-01-01

Microparticulate perfluorochemical (PFC) emulsions have the capacity to solubilize significant quantities of oxygen compared to water. Although systemic administration of such emulsions may enhance oxygen delivery to some tissues, hypoxic tumor cells have marginal vascular supplies. The authors report studies which directly attempt to oxygenate hypoxic tumor cells by interstitial administration of oxygenated PFC emulsions followed by radiation therapy. Fortner MMI malignant melanomas (21 day old) grown in Syrian Golden hamsters were injected directly with either oxygenated PFC emulsions or Ringers solution. The volume of test substance administered was equal to 50% of the tumor volume. The tumors were immediately irradiated with 25 Gy of 10 MeV photons (Clinac 18). The tumor dimensions were measured daily post irradiation and the tumor doubling time determined. The results suggest that interstitial administration of oxygenated PFC emulsions directly into tumors followed by radiation therapy may increase the likelihood of killing hypoxic tumor cells

A systemic administration of liposomal curcumin inhibits radiation pneumonitis and sensitizes lung carcinoma to radiation

Directory of Open Access Journals (Sweden)

Shi HS

2012-05-01

Full Text Available Hua-shan Shi1,* Xiang Gao,1,3,* Dan Li,1,* Qiong-wen Zhang,1 Yong-sheng Wang,2 Yu Zheng,1 Lu-Lu Cai,1 Ren-ming Zhong,2 Ao Rui,1 Zhi-yong Li,1 Hao Zheng,1 Xian-cheng Chen,1 Li-juan Chen,11State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medicine School, Sichuan University, Chengdu, Sichuan, People's Republic of China; 2State Key Laboratory of Biotherapy and Department of Thoracic Oncology, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan, People's Republic of China; 3Deparment of Pathophysiology, College of Preclinical and Forensic Medical Sciences, Sichuan University, Chengdu, People's Republic of China*These authors contributed equally to this workAbstract: Radiation pneumonitis (RP is an important dose-limiting toxicity during thoracic radiotherapy. Previous investigations have shown that curcumin is used for the treatment of inflammatory conditions and cancer, suggesting that curcumin may prevent RP and sensitize cancer cells to irradiation. However, the clinical advancement of curcumin is limited by its poor water solubility and low bioavailability after oral administration. Here, a water-soluble liposomal curcumin system was developed to investigate its prevention and sensitizing effects by an intravenous administration manner in mice models. The results showed that liposomal curcumin inhibited nuclear factor-κB pathway and downregulated inflammatory factors including tumor necrosis factor-α, interleukin (IL-6, IL-8, and transforming growth factor-β induced by thoracic irradiation. Furthermore, the combined treatment with liposomal curcumin and radiotherapy increased intratumoral apoptosis and microvessel responses to irradiation in vivo. The significantly enhanced inhibition of tumor growth also was observed in a murine lung carcinoma (LL/2 model. There were no obvious toxicities observed in mice. The current results indicate that liposomal curcumin can effectively

14 August 1981 - Royal Order on the organization and administrative status of the personnel of the Service for Protection against Ionizing Radiation

International Nuclear Information System (INIS)

1981-01-01

This Order concerns the organization and the administrative structure of the Service for Protection against Ionizing Radiations. The Service, within the Ministry of Public Health and the Family, is responsible, inter alia, for controlling the application of legislation on radiation protection, for examining licensing applications for nuclear facilities and import and transport of radioactive substances. (NEA) [fr

Radiation protection for industrial radiography in the aerospace industry

International Nuclear Information System (INIS)

Morgan, W.E.

1980-01-01

The Boeing Company employs 80 industrial radiographers, operates 90 radiation sources, and takes 10,000 exposures per month. This paper describes the major components of Boeing's radiation protection program: hazard analysis, facilities and equipment design, program administration, and evaluation. In the hazard analysis, each source of radiation is analyzed to determine its hazard and relationship to both man and the environment around it. Once the degree of the hazard is known, facilities and equipment are designed to contain the hazard. This can be anything from a four foot concrete shielded room for an industrial radiographic accelerator, to a piece of rope that isolates an Iridium-192 source during a field radiographic inspection on an aircraft. The administrative functions provide the necessary records, command media, and a radiation source certification program. This certification authorizes the source of radiation to be used under specific conditions agreed upon by both the Radiation Protection Organization and Industrial Radiography Management. The radiation protection program is evaluated through medical exams, personnel monitoring, and area radiation surveys. (H.K.)

Determination of the gamma radiation scattering with geometry changes in the system

International Nuclear Information System (INIS)

Albuquerque, M. da P.P.; Xavier, M.; Caldas, L.V.E.

1988-07-01

Three different experimental systems were used for the determination of the radiation scattering due to the walls, ceiling and floor of the Calibration Laboratory. The radiation detection was made with a portable ionization chamber Victoreen model Panoramic 470. The measurements were taken with and without the use of a lead shield block between the detector and the radioactive source. The results showed that the scattering contribution increased about 80%, as the distance between detector and source was varied from 1,0 to 2,0 m. Therefore the scattering contribution determination is very important for the establishment of the standard radiation fields for instruments calibration. (author) [pt

Absolute exposure determination of cobalt-60 gamma radiation

International Nuclear Information System (INIS)

Ahmad, S.S.; Ali, A.; Orfi, S.D.

1986-02-01

The report describes the procedure for the determination of absolute exposure for Cobalt-60 gamma radiation. A graphite cavity chamber, nominal volume of 1 cm 3 , manufactured by Austrian Research Centre Seibersdorf has been used. The exposure rate at reference distance determined with the graphite chamber was compared with mean exposure rate measured with NPL-Therapy level X-ray exposure meter normalized to same date. An agreement of 0.39% was found between the two measuring systems, which seems to be very encouraging and quite satisfactory. (authors)

Using Procedure Codes to Define Radiation Toxicity in Administrative Data: The Devil is in the Details.

Science.gov (United States)

Meyer, Anne-Marie; Kuo, Tzy-Mey; Chang, YunKyung; Carpenter, William R; Chen, Ronald C; Sturmer, Til

2017-05-01

Systematic coding systems are used to define clinically meaningful outcomes when leveraging administrative claims data for research. How and when these codes are applied within a research study can have implications for the study validity and their specificity can vary significantly depending on treatment received. Data are from the Surveillance, Epidemiology, and End Results-Medicare linked dataset. We use propensity score methods in a retrospective cohort of prostate cancer patients first examined in a recently published radiation oncology comparative effectiveness study. With the narrowly defined outcome definition, the toxicity event outcome rate ratio was 0.88 per 100 person-years (95% confidence interval, 0.71-1.08). With the broadly defined outcome, the rate ratio was comparable, with 0.89 per 100 person-years (95% confidence interval, 0.76-1.04), although individual event rates were doubled. Some evidence of surveillance bias was suggested by a higher rate of endoscopic procedures the first year of follow-up in patients who received proton therapy compared with those receiving intensity-modulated radiation treatment (11.15 vs. 8.90, respectively). This study demonstrates the risk of introducing bias through subjective application of procedure codes. Careful consideration is required when using procedure codes to define outcomes in administrative data.

Annual report on the administration of the Radiation Control for health and Safety Act of 1968, Public Law 90-602, April 1, 1991. Rept. for Jan-Dec 90

International Nuclear Information System (INIS)

1991-01-01

The Secretary of Health and Human Services is required by Subpart 3, Part F of Title III of the Public Health Service Act; 42 USC 263b et seq. (Public Law 90-602) to submit an annual report to the President for transmittal to the Congress on or before April 1 on the administration of the Radiation Control for Health and Safety Act. The detailed information required in the report is outlined in Section 360D of the Public Health Service Act. The Food and Drug Administration, through its Center for Devices and Radiological Health, is responsible for the day-to-day administration of the Radiation Control for Health and Safety Act of 1968. The report provides a summary of the operations of the Center in carrying out that responsibility for calendar year 1990. In reviewing the operations of the Center for Devices and Radiological Health as reported in the document, it should be kept in mind that the day-to-day administration of the Act is only part of the Center's function. Other responsibilities include the administration and enforcement of the 1976 Medical Device Amendments to the Federal Food, Drug, and Cosmetic Act (not covered in the report). Manufacturers of electronic products are required by 21 CFR 1002.20 to report accidental radiation occurrences to the Center for Devices and Radiological Health. The Center no longer maintains a Radiation Incidents Registry, since accidental radiation occurrences are reported through the Device Experience Network (DEN) and through the requirements of the Medical Device Reporting (MDR) Regulations

1991 implementation of As Low As Reasonably Achievable (ALARA) administrative radiation exposure levels: Experiences and lessons learned

International Nuclear Information System (INIS)

Aldridge, T.L.; Baumann, B.L.

1993-06-01

As Low As Reasonably Achievable (ALARA) radiation exposure levels were implemented on January 1, 1991, by Westinghouse Hanford Company (WHC), a prime US Department of Energy (DOE) contractor, located in Richland, Washington. This paper describes the radiation exposure levels which were implemented and the associated experiences and lessons learned. The issue of a report from the Committee on Biological Effectiveness of Ionizing Radiation in 1989 prompted DOE to re-evaluate its position on radiation exposure limits and the resulting doses received by occupational radiation workers. DOE requested that all it's contractors determine the impacts to operations from reduced radiation exposure levels

System for determining absorbed dose and its distribution for high-energy electron radiation

International Nuclear Information System (INIS)

Hegewald, H.; Wulff, W.

1977-01-01

Taking into account the polarization effect, the dose determination for high-energy electron radiation from particle accelerators depends on the knowledge of the energy dependence of the mass stopping power. Results obtained with thermoluminescent dosemeters agree with theoretical values. For absorbed dose measurements the primary energy of electron radiation has been determined by nuclear photoreactions, and the calculation of the absorbed dose from charge measurements by means of the mass stopping power is described. Thus the calibration of ionization chambers for high-energy electron radiation by absolute measurements with the Faraday cage and chemical dosemeters has become possible. (author)

Practicing radiation oncology in the current health care environment - Part III: Information systems for radiation oncology practice

International Nuclear Information System (INIS)

Kijewski, Peter

1996-01-01

Purpose: This course will review topics to be considered when defining an information systems plan for a department of radiation oncology. A survey of available systems will be presented. Computer information systems can play an important role in the effective administration and operation of a department of radiation oncology. Tasks such as 1) scheduling for physicians, patients, and rooms, 2) charge collection and billing, 3) administrative reporting, and 4) treatment verification can be carried out efficiently with the assistance of computer systems. Operating a department without a state of art computer system will become increasingly difficult as hospitals and healthcare buyers increasingly rely on computer information technology. Communication of the radiation oncology system with outside systems will thus further enhance the utility of the computer system. The steps for the selection and installation of an information system will be discussed: 1) defining the objectives, 2) selecting a suitable system, 3) determining costs, 4) setting up maintenance contracts, and 5) planning for future upgrades

Engineered and Administrative Safety Systems for the Control of Prompt Radiation Hazards at Accelerator Facilities

International Nuclear Information System (INIS)

Liu, James C.; SLAC; Vylet, Vashek; Walker, Lawrence S.

2007-01-01

The ANSI N43.1 Standard, currently in revision (ANSI 2007), sets forth the requirements for accelerator facilities to provide adequate protection for the workers, the public and the environment from the hazards of ionizing radiation produced during and from accelerator operations. The Standard also recommends good practices that, when followed, provide a level of radiation protection consistent with those established for the accelerator communities. The N43.1 Standard is suitable for all accelerator facilities (using electron, positron, proton, or ion particle beams) capable of producing radiation, subject to federal or state regulations. The requirements (see word 'shall') and recommended practices (see word 'should') are prescribed in a graded approach that are commensurate with the complexity and hazard levels of the accelerator facility. Chapters 4, 5 and 6 of the N43.1 Standard address specially the Radiation Safety System (RSS), both engineered and administrative systems, to mitigate and control the prompt radiation hazards from accelerator operations. The RSS includes the Access Control System (ACS) and Radiation Control System (RCS). The main requirements and recommendations of the N43.1 Standard regarding the management, technical and operational aspects of the RSS are described and condensed in this report. Clearly some aspects of the RSS policies and practices at different facilities may differ in order to meet the practical needs for field implementation. A previous report (Liu et al. 2001a), which reviews and summarizes the RSS at five North American high-energy accelerator facilities, as well as the RSS references for the 5 labs (Drozdoff 2001; Gallegos 1996; Ipe and Liu 1992; Liu 1999; Liu 2001b; Rokni 1996; TJNAF 1994; Yotam et al. 1991), can be consulted for the actual RSS implementation at various laboratories. A comprehensive report describing the RSS at the Stanford Linear Accelerator Center (SLAC 2006) can also serve as a reference

Cell kinetic studies on radiation induced leukemogenesis

International Nuclear Information System (INIS)

Nakao, Isamu; Suzuki, Gen; Imai, Yasufumi; Kawase, Yoshiko; Nose, Masako; Hirashima, Kunitake; Bessho, Masami

1989-01-01

The purpose of this study was threefold: (1) to determine the clonal origin of radiation-induced thymic lymphoma in mice with cellular mosaicism for phosphoglycerate kinase; (2) to determine the incidence and latent period of myeloid leukemia and thymic lymphoma induced by whole-body exposure to median doses (3.0 Gy or less) in RFM/MsNrs-2 mice; and (3) to examine the influence of human recombinant interleukin-2 (hrIL-2). Thymic lymphoma was of a single cell origin. The incidence of radiation-induced myeloid leukemia and thymic lymphoma in RFM mice increased in a dose dependent fashion. Mean latent periods of both myeloid leukemia and thymic lymphoma after irradiation became shorter in proportion to radiation doses. When hrIL-2 was injected to RFM mice receiving 3.0 Gy, mean survivals were shorter in thymoma-bearing mice than the control mice. This suggested that hrIL-2 shortens the promotion step of thymoma. Administration of hrIL-2 failed to alter the incidence of myeloid leukemia or the mean survival of mice having myeloid leukemia, indicating that the protocol of hrIL-2 administration was not so sufficient as to alter the myeloid leukemogenesis. (Namekawa, K)

DETERMINATION OF RADIATOR COOLING SURFACE

Directory of Open Access Journals (Sweden)

A. I. Yakubovich

2009-01-01

Full Text Available The paper proposes a methodology for calculation of a radiator cooling surface with due account of heat transfer non-uniformity on depth of its core. Calculation of radiator cooling surfaces of «Belarus-1221» and «Belarus-3022» tractors has been carried out in the paper. The paper also advances standard size series of radiators for powerful «Belarus» tractor type.

Determination of radiation dose rates and urinary activity of patients received Sodium Iodide-131 for treatment of differentiated thyroid carcinoma

International Nuclear Information System (INIS)

Beiki, D.; Shahhosseini, S.; Dadashzadeh, S.; Eftekhari, M.; Tayebi, H.; Moosazadeh-Rashti, G.

2004-01-01

Sodium Iodide-131 is administrated for treatment of hyperthyroidism and thyroid cancer. Iodine-131 has multiple routs of excretion (urine, saliva, sweat, milk, feces, exhalation) from the body. Patients receiving Sodium Iodide-131 therapy exposes other persons and the environment to unwanted radiation and contamination. The major sources of radiation dose from administration of Iodine-131 is external radiation , also there is a potential for exposure via contamination.Precautions are necessary to limit the radiation dose to family members, nursing staff and members of public and waste treatment workers to less than 1mSv. Patients received Sodium Iodide-131 may come into close contact with other persons. In order to derive appropriate recommendations, dose rates were measured from the anterior mid-trunk of 29 patients in the upright position with 15 minutes post-dose administration at 3 meters and just before they left the nuclear medicine department at 0.5, 1, and 3 meters. We have also measured urinary iodide excretion in 29 patients to estimate Sodium Iodide-131 urinary excretion pattern in iranian patients. Based on results, the maximum cumulative dose to nursing staff was on third day (leaving day) still less than recommended dose bye ICRP. The cumulative dose family members will be more but regarding the time and distance in close contact it will be also less than recommended dose by ICRP.Radiation dose rate was decreased significantly on third day. The urinary excretion patterns in all patients were similar. The urinary excretion rate-time curve in all patients showed multiple peaks due to retention and redistribution of Iodine-131 or enterohepatic cycle of radioiodinated thyroid hormones, which didn't allow calculation of urinary excretion rate constant. The results also showed that 67 hours post administration of Sodium Iodide-131 about 70% of radiopharmaceutical was excreted through urine, 28% physically decayed or eliminated through other biological

Human radiation studies: Remembering the early years. Oral history of Donner Lab Administrator Baird G. Whaley, August 15, 1994

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-09-01

Baird G. Whaley, Donner Lab Administrator, was interviewed by representatives of US DOE Office of Human Radiation Experiments (OHRE). The purpose of the interview was to capture the remembrances of Mr. Whaley concerning what he could relate on activities at the Donner Lab that pertain to the OHRE responsibilities. Following a brief biographical sketch, Mr. Whaley relates his experiences in administration at the LAB including funding activities, staffing concerns, intralaboraory politics, and remembrances of John Lawrence, John Gofman, Cornelius Tobias, Jim Born, Alex Margolis, B.V.A. Low- Beer, and Ed Alpen. Further patient care procedures for Donner Clinic Research Programs were discussed.

Human radiation studies: Remembering the early years. Oral history of Donner Lab Administrator Baird G. Whaley, August 15, 1994

International Nuclear Information System (INIS)

1995-09-01

Baird G. Whaley, Donner Lab Administrator, was interviewed by representatives of US DOE Office of Human Radiation Experiments (OHRE). The purpose of the interview was to capture the remembrances of Mr. Whaley concerning what he could relate on activities at the Donner Lab that pertain to the OHRE responsibilities. Following a brief biographical sketch, Mr. Whaley relates his experiences in administration at the LAB including funding activities, staffing concerns, intralaboraory politics, and remembrances of John Lawrence, John Gofman, Cornelius Tobias, Jim Born, Alex Margolis, B.V.A. Low- Beer, and Ed Alpen. Further patient care procedures for Donner Clinic Research Programs were discussed

Radiation exposure near of patients after administration of 99mTc-Sestamibi

International Nuclear Information System (INIS)

Kurtaran, A.; Preitfellner, J.; Virgolini, I.; Schaffarich, P.; Scheuba, C.; Niederle, B.; Havlik, E.

1997-01-01

Aim: The aim of the present study was to estimate the additional radiation exposure to personnel, other patients and members of the family caused by patients who had been injected with 99m Tc-Sestamibi (Cardiolite R DuPONT PHARMA) for preoperative localization of parathyroid adenoma. Methods: Dose rates were measured from 16 patients who had received an intravenous injection of 600±50 MBq 99m Tc-Sestamibi. All measurements were performed with a portable dosimeter (Berthold LB 133 R ) at 3 different distances (0.5, 1 and 2 m) at 10 min, 180-200 min and 24 h after administration of the tracer. Results: The dose rates amounted to 20.5 μSv/h at 0.5 m, 5.25 μSv/h at 1 m and 1.55 μSv/h at 2 m distance from patients respectively. The biological half-life was 54 h. The calculated maximal dose to other persons in the waiting area was 31.2 μSv, to family members 27.6 μSv and to nurses in a ward 31.2 μSv. Conclusion: Our results indicate that the calculated maximal radiation exposure for personnel, family members and other patients even under very unfavourable conditions was below the maximal allowed dose for non-professionally exposed persons. (orig.) [de

Application of Monte Carlo method in determination of secondary characteristic X radiation in XFA

International Nuclear Information System (INIS)

Roubicek, P.

1982-01-01

Secondary characteristic radiation is excited by primary radiation from the X-ray tube and by secondary radiation of other elements so that excitations of several orders result. The Monte Carlo method was used to consider all these possibilities and the resulting flux of characteristic radiation was simulated for samples of silicate raw materials. A comparison of the results of these computations with experiments allows to determine the effect of sample preparation on the characteristic radiation flux. (M.D.)

12 CFR 505.4 - Administrative appeal of initial determination to deny records.

Science.gov (United States)

2010-01-01

... 12 Banks and Banking 5 2010-01-01 2010-01-01 false Administrative appeal of initial determination to deny records. 505.4 Section 505.4 Banks and Banking OFFICE OF THRIFT SUPERVISION, DEPARTMENT OF.... Appeals may be delivered personally to FOIA Appeals, Office of Thrift Supervision, 1700 G Street, NW...

Myocardial hydroxyproline reduced by early administration of methylprednisolone or ibuprofen to rabbits with radiation-induced heart disease

International Nuclear Information System (INIS)

Reeves, W.C.; Cunningham, D.; Schwiter, E.J.; Abt, A.; Skarlatos, S.; Wood, M.A.; Whitesell, L.

1982-01-01

The ability of methylprednisolone (MP) and ibuprofen (IB) to reduce the severity of the late state of radiation-induced heart disease was assessed in 57 New Zealand white rabbits. Before and shortly after cardiac irradiation, 15 rabbits received i.v. MP, 30 mg/kg twice daily for 3 days, and 15 others received IB, 12.5 mg/kg twice daily for 2 days. No drug administered to 14 irradiated rabbits, and neither irradiation nor drugs were administered to 13 rabbits that served as controls. All 15 rabbits treated with MP and 13 of the 15 treated with IB lived for 100 days. Only seven of the untreated, irradiated rabbits lived that long. Longevity of each treated group of rabbits was better (p < 0.01 and 0.05) than that of the untreated, irradiated rabbits. Surviving rabbits were killed 100 days after irradiation. Pericarditis (p < 0.05) and pericardial effusion (p < 0.01) were less frequent in the treated, irradiated groups than in the untreated, irradiated rabbits. At least some rabbits in each irradiated group had microscopic evidence of myocardial fibrosis. The fibrosis was quantitated by determination of myocardial hydroxyproline concentrations (MHP). MHP concentration in the untreated, irradiated rabbits was greater than in those treated with MP (p < 0.05) or IB (p < 0.01) and in the untreated, unirradiated rabbits (p < 0.01). Early administrative of MP or IB retarded the development of myocardial fibrosis, pericarditis and pericardial effusin, and improved survival in this experimental model of radiation-induced heart disease

Determination of radiation levels by neutrons in an accelerator for radiotherapy

International Nuclear Information System (INIS)

Paredes G, L.; Salazar B, M.A.; Genis S, R.

1998-01-01

It was determined the radiation levels by neutrons due to photonuclear reactions (γ, n) which occur in the target, levelling filter, collimators and the small pillow blinding of a medical accelerator Varian Clinac 2100C of 18 MeV, using thermoluminescent dosemeters UD-802AS and US-809AS. The experimental values were presented for the patient level, inside and outside of the radiation field, as well as for the small pillow. (Author)

ISLSCP II Surface Radiation Budget (SRB) Radiation Data

Data.gov (United States)

National Aeronautics and Space Administration — ABSTRACT: This data set contains global Surface Radiation Budget (SRB) and a few top-of-atmosphere (TOA) radiation budget parameters on a 1-degree x 1-degree spatial...

Research on determination of bio-burden for radiation sterilization of health care products

International Nuclear Information System (INIS)

Liu Qinfang

2008-01-01

In order to provide data of bio-burden for dose setting in radiation sterilization, determination of bio-burden on 148 kinds of health care products from 52 manufacturers were carried out. The culture of microorganisms, different elution technology, and correction coefficient of the microbiological methods have been used for determination of bio-burden. Frequent distribution of bio-burden was established. 5 kinds of elution processes were checked. Actual data of bio-burden for dose setting in radiation sterilization was gotten. (authors)

Cerebrovascular Acute Radiation Syndrome : Radiation Neurotoxins, Mechanisms of Toxicity, Neuroimmune Interactions.

Science.gov (United States)

Popov, Dmitri; Maliev, Slava

Introduction: Cerebrovascular Acute Radiation Syndrome (CvARS) is an extremely severe in-jury of Central Nervous System (CNS) and Peripheral Nervous System (PNS). CvARS can be induced by the high doses of neutron, heavy ions, or gamma radiation. The Syndrome clinical picture depends on a type, timing, and the doses of radiation. Four grades of the CvARS were defined: mild, moderate, severe, and extremely severe. Also, four stages of CvARS were developed: prodromal, latent, manifest, outcome -death. Duration of stages depends on the types, doses, and time of radiation. The CvARS clinical symptoms are: respiratory distress, hypotension, cerebral edema, severe disorder of cerebral blood microcirculation, and acute motor weakness. The radiation toxins, Cerebro-Vascular Radiation Neurotoxins (SvARSn), determine development of the acute radiation syndrome. Mechanism of action of the toxins: Though pathogenesis of radiation injury of CNS remains unknown, our concept describes the Cv ARS as a result of Neurotoxicity and Excitotoxicity, cell death through apoptotic necrosis. Neurotoxicity occurs after the high doses radiation exposure, formation of radiation neuro-toxins, possible bioradicals, or group of specific enzymes. Intracerebral hemorrhage can be a consequence of the damage of endothelial cells caused by radiation and the radiation tox-ins. Disruption of blood-brain barrier (BBB)and blood-cerebrospinal fluid barrier (BCFB)is possibly the most significant effect of microcirculation disorder and metabolic insufficiency. NMDA-receptors excitotoxic injury mediated by cerebral ischemia and cerebral hypoxia. Dam-age of the pyramidal cells in layers 3 and 5 and Purkinje cell layer the cerebral cortex , damage of pyramidal cells in the hippocampus occur as a result of cerebral ischemia and intracerebral bleeding. Methods: Radiation Toxins of CV ARS are defined as glycoproteins with the molec-ular weight of RT toxins ranges from 200-250 kDa and with high enzymatic activity

Administration of the Radiation Control for Health Safety Act of 1968, public law 90-602, April 1, 1984 (1983 annual report)

International Nuclear Information System (INIS)

1984-01-01

The Food and Drug Administration through its National Center for Devices and Radiological Health, is responsible for the day-to-day administration of the Radiation Control for Health and Safety Act. This report covers the detailed operation of the Agency in carrying out that responsibility for calendar year 1983. There are nine equipment performance or regulatory standards (television receivers, cold-cathode gas discharge tubes, microwave ovens, diagnostic x-ray systems, cabinet x-ray systems, laser products, ultrasonic therapy products, mercury vapor lamps, and sunlamp products) now in effect

External radiation exposure after deposition of man-made radionuclides

International Nuclear Information System (INIS)

Jacob, P.

1991-01-01

The first step in assessing the external radiation exposure of the population is the determination of the gamma dose rate over meadows, which are used as reference points for various reasons. The second step is the description of external radiation exposures in urban and rural environments. The relation to the radiation exposure in a meadow is a function of the radionuclide distribution, i.e. the type of deposition. Finally, a simple method of calculating external radiation exposure is developed on the basis of recent findings. The method is compared with the method used in the UNSCEAR report for calculating radiation exposures after Chernobyl and with the method described in the AVV (General Administrative Regulation) of the Radiation Protection Ordinance. (orig./HP) [de

Techniques for detecting and determining risks from low-level radiation

International Nuclear Information System (INIS)

Boice, J.D.

1980-01-01

Epidemiology is the study of disease in man. In evaluating radiation hazards, analytic studies have utilized the cohort type of investigation (where persons exposed and not exposed to radiation are followed forward in time for determination of disease experience) or case-control approaches (where persons with and without a specific disease are evaluated for previous exposure to radiation). Most radiation studies have evaluated cohorts (e.g., radiologists), although important case-control studies have been conducted (e.g., childhood leukemia as related to prenatal x ray). At its best, epidemiology is capable fo evaluating relative risks (RR) on the order of 1.4 (i.e., a 40% relative excess). However, the RRs of interest following low doses of radiation (1 rad) are on the order of 1.02-1.002. Thus, not much should be anticipated from direct observations at 1 rad, and indirect approaches must be taken to estimate low-dose effects. Such indirect approaches include evaluating 1) populations exposed to a range of doses, both low and high, where interpolation models can be reasonably applied to estimate low-dose effects; and 2) populations exposed to fractionated doses over a long period of time where the resulting dose-effect relationship theoretically should be linear and the estimation of low-level health effects facilitated

Annual report on the administration of the Radiation Control for Health and Safety Act of 1968, Public Law 90-602, (1988), April 1, 1989. Annual report

International Nuclear Information System (INIS)

1989-01-01

The Secretary of Health and Human Services is required by Subpart 3, Part F of Title III of the Public Health Service Act; 42 USC 263b et seq. (Public Law 90-602) to submit an annual report to the President for transmittal to the Congress on or before April 1 on the administration of the Radiation Control for Health and Safety Act. The detailed information required in the report is outlined in Section 360D of the Public Health Service Act. The Food and Drug Administration, through its Center for Devices and Radiological Health, is responsible for the day-to-day administration of the Radiation Control for Health and Safety Act of 1968. The report provides a summary of the operations of the Center in carrying out that responsibility for calendar year 1988. In reviewing the operations of the Center for Devices and Radiological Health as reported in the document, it should be kept in mind that the day-to-day administration of the Act is only part of the Center's function. Other responsibilities include the administration and enforcement of the 1976 Medical Device Amendments to the Federal Food, Drug, and Cosmetic Act (not covered in the report)

Assessment of the methods for determining net radiation at different time-scales of meteorological variables

Directory of Open Access Journals (Sweden)

Ni An

2017-04-01

Full Text Available When modeling the soil/atmosphere interaction, it is of paramount importance to determine the net radiation flux. There are two common calculation methods for this purpose. Method 1 relies on use of air temperature, while Method 2 relies on use of both air and soil temperatures. Nowadays, there has been no consensus on the application of these two methods. In this study, the half-hourly data of solar radiation recorded at an experimental embankment are used to calculate the net radiation and long-wave radiation at different time-scales (half-hourly, hourly, and daily using the two methods. The results show that, compared with Method 2 which has been widely adopted in agronomical, geotechnical and geo-environmental applications, Method 1 is more feasible for its simplicity and accuracy at shorter time-scale. Moreover, in case of longer time-scale, daily for instance, less variations of net radiation and long-wave radiation are obtained, suggesting that no detailed soil temperature variations can be obtained. In other words, shorter time-scales are preferred in determining net radiation flux.

Management of radioisotope, radiation generator and fuel materials for independent administrative corporations of national university

International Nuclear Information System (INIS)

2003-03-01

This report states the situation, problems and proposal of management of radioisotope, radiation generator and fuel materials by independent administrative corporations of national universities. Four proposals are stated as followings; 1) in order to improve management of radioisotope, radiation generator, fuel materials and X-ray in the universities, organization and definition of the control department in each university and accident measures have to be decided. The middle object and plan should be needed. An appropriate management for proceeding researches should be discussed by closer connection of universities in the country. 2) The budget for safety control has to be identified at distribution of budget of each national university corporations. The insurance method is needed to be discussed. 3) The department in the MEXT (Ministry of Education, Culture, Sports, Science and Technology) should be enriched to support researches and safety control of the staff and students. 4) The system, which carries out treatment and disposal of disuse materials and keeps them under the responsibility of the nation, is necessary. (S.Y.)

A simple model for determining photoelectron-generated radiation scaling laws

International Nuclear Information System (INIS)

Dipp, T.M.

1993-12-01

The generation of radiation via photoelectrons induced off of a conducting surface was explored using a simple model to determine fundamental scaling laws. The model is one-dimensional (small-spot) and uses monoenergetic, nonrelativistic photoelectrons emitted normal to the illuminated conducting surface. Simple steady-state radiation, frequency, and maximum orbital distance equations were derived using small-spot radiation equations, a sin 2 type modulation function, and simple photoelectron dynamics. The result is a system of equations for various scaling laws, which, along with model and user constraints, are simultaneously solved using techniques similar to linear programming. Typical conductors illuminated by low-power sources producing photons with energies less than 5.0 eV are readily modeled by this small-spot, steady-state analysis, which shows they generally produce low efficiency (η rsL -10.5 ) pure photoelectron-induced radiation. However, the small-spot theory predicts that the total conversion efficiency for incident photon power to photoelectron-induced radiated power can go higher than 10 -5.5 for typical real conductors if photons having energies of 15 eV and higher are used, and should go even higher still if the small-spot limit of this theory is exceeded as well. Overall, the simple theory equations, model constraint equations, and solution techniques presented provide a foundation for understanding, predicting, and optimizing the generated radiation, and the simple theory equations provide scaling laws to compare with computational and laboratory experimental data

Administration of the Radiation Control for Health and Safety Act of 1968, Public Law 90-602, April 1, 1985 (1984 annual report). Report for 1 January-31 December 1984

International Nuclear Information System (INIS)

1985-01-01

The Secretary of Health and Human Services is required by Subpart 3, Part F of Title III of the Public Health Service Act; 42 USC 263b et seq. (Public Law 90-602) to submit an annual report to the President for transmittal to the Congress on or before April 1 on the administration of the Radiation Control for Health and Safety Act. The detailed information required to be included in the report is outlined in Section 360D of the Public Health Service Act. The Food and Drug Administration, through its Center for Devices and Radiological Health, is responsible for the day-to-day administration of the Act. The report covers the detailed operation of the Agency in carrying out that responsibility for calendar year 1984. Manufacturers of electronic products are required by 21 CFR 1002.20 to report accidental radiation occurrences to the CDRH, FDA. During the calendar year 1984, the Radiation Incidents Registry received 11 reports alleging injury involving 235 persons

Reduction of Radiation-Induced Changes in Biophysical Properties of Erythrocytes

International Nuclear Information System (INIS)

El-Marakby, S.M.A.

2014-01-01

The increase in uses of nuclear technologies in power production, medical and industrial applications enhanced the probability of accidental radiation exposure to occupational workers, patients and public, thereafter increasing hazardous health effects. In comparison with planned radiation exposure during diagnosis and therapy, the management of accidental radiation exposure is relatively complicated due to uncertainties in dose, duration, organs involved in radiation exposure. Although radiation accidents are not common, human error, failure to follow safety precautions and inadequate control and regulation of radiation sources have led to deaths and significant exposures among workers and members of the public. Treatment of the victim in this case needs information and measurements that may take time in order to determine the suitable therapeutic strategy for its case. However, after the event of the radiation accident, it will be important to provide an agent that would mitigate the effects of exposure to ionizing radiation and can promote or increase the efficiency of the treatment. Ideally this agent would be long-lasting, be easily administered (preferably orally) and possesses low toxicity. Development of agents for prophylaxis, mitigation and treatment of radiation injury is an important task for radiological studies. The aim of the present work is to study the prophylactic and mitigation effect of poly-MVA (a dietary supplement of Palladiumlipoic acid nano-complex) against acute whole body gamma irradiation through measurements of biophysical changes in blood erythrocytes of rats. Adult male rats were exposed to 6 Gy single dose from Cs- 137 source. The animals received daily oral administration of 2ml/Kg body weight of poly-MVA with three different time intervals. The prophylactic effect was examined by two modes of administration: first mode was uptake of poly-MVA for two weeks before irradiation then the administration was stopped and the second animal

Myocardial hydroxyproline reduced by early administration of methylprednisolone or ibuprofen to rabbits with radiation-induced heart disease

International Nuclear Information System (INIS)

Reeves, W.C.; Cunningham, D.; Schwiter, E.J.; Abt, A.; Skarlatos, S.; Wood, M.A.; Whitesell, L.

1982-01-01

The ability of methylprednisolone (MP) and ibuprofen (IB) to reduce the severity of the late state of radiation-induced heart disease was assessed in 57 New Zealand white rabbits. Before and shortly after cardiac irradiation, 15 rabbits received i.v. MP, 30 mg/kg twice daily for 3 days, and 15 others received IB, 12.5 mg/kg twice daily for 2 days. No drug was administered to 14 irradiated rabbits, and neither irradiation nor drugs were administered to 13 rabbits that served as controls, All 15 rabbits treated with MP and 13 of the 15 treated with IB lived for 100 days. Only seven of the untreated, irradiated rabbits lived that long. Longevity of each treated group of rabbits was better (p less than 0.01 and 0.05) than that of the untreated, irradiated rabbits. Surviving rabbits were killed 100 days after irradiation. Pericarditis (p less than 0.05) and pericardial effusion (p less than 0.01) were less frequent in the treated, irradiated groups than in the untreated, irradiated rabbits. At least some rabbits in each irradiated group had microscopic evidence of myocardial fibrosis. The fibrosis was quantitated by determination of myocardial hydroxyproline concentrations (MHP). MHP concentration in the untreated, irradiated rabbits was greater than in those treated with MP (p less than 0.05) or IB (p less than 0.01) and in the untreated, unirradiated rabbits (p less than 0.01). Early administration of MP or IB retarded the development of myocardial fibrosis, pericarditis and pericardial effusion, and improved survival in this experimental model of radiation-induced heart disease

Determination of alternative conditions for instruments calibration with beta radiation

International Nuclear Information System (INIS)

Rocha, F.D.G.; Caldas, L.V.E.

1992-01-01

The influence of homogenization filter in the determination of chamber calibration factors and transmission factors of beta radiation in air, for obtaining different alternative conditions for beta-gamma portable monitors calibration was studied, using an extrapolation chamber and the beta secondary system at IPEN-CNEN-Brazil. (C.G.C.)

Microhardness technique for determination of radiation hardening in austenitic stainless steel using

International Nuclear Information System (INIS)

Hofman, A.

1995-01-01

The use of microhardness technique to determine the radiation hardening has been studied. Microhardness measurements have been conducted on austenitic stainless steel 0H18N10T irradiated up to 2·10 23 nm -2 . It was determined that the increase in microhardness varies directly with the measured increase in the 0,2% offret yield strength and has been found that microhardness technique may be an effective tool to measurements of radiation induced hardening. Based on the results and Cahoon's relation that σ 0,2 (MPa)=3,27HV(0,1) n method for evaluating the yield stress σ 0,2 by microhardness technique is analyzed. 14 refs., 3 figs., 3 tabs

HAMLET -Human Model MATROSHKA for Radiation Exposure Determination of Astronauts -Current status and results

Science.gov (United States)

Reitz, Guenther; Berger, Thomas; Bilski, Pawel; Burmeister, Soenke; Labrenz, Johannes; Hager, Luke; Palfalvi, Jozsef K.; Hajek, Michael; Puchalska, Monika; Sihver, Lembit

The exploration of space as seen in specific projects from the European Space Agency (ESA) acts as groundwork for human long duration space missions. One of the main constraints for long duration human missions is radiation. The radiation load on astronauts and cosmonauts in space (as for the ISS) is a factor of 100 higher than the natural radiation on Earth and will further increase should humans travel to Mars. In preparation for long duration space missions it is important to evaluate the impact of space radiation in order to secure the safety of the astronauts and minimize their radiation risks. To determine the radiation risk on humans one has to measure the radiation doses to radiosensitive organs within the human body. One way to approach this is the ESA facility MATROSHKA (MTR), under the scientific and project lead of DLR. It is dedicated to determining the radiation load on astronauts within and outside the International Space Station (ISS), and was launched in January 2004. MTR is currently preparing for its fourth experimental phase inside the Japanese Experimental Module (JEM) in summer 2010. MTR, which mimics a human head and torso, is an anthropomorphic phantom containing over 6000 radiation detectors to determine the depth dose and organ dose distribution in the body. It is the largest international research initiative ever performed in the field of space dosimetry and combines the expertise of leading research institutions around the world, thereby generating a huge pool of data of potentially immense value for research. Aiming at optimal scientific exploitation, the FP7 project HAMLET aims to process and compile the data acquired individually by the participating laboratories of the MATROSHKA experiment. Based on experimental input from the MATROSHKA experiment phases as well as on radiation transport calculations, a three-dimensional model for the distribution of radiation dose in an astronaut's body will be built up. The scientific achievements

Determining the Knowledge Level of Pre-Service Teachers' on Radioactivity and Radiation

Science.gov (United States)

Ergul, N. Remziye

2012-01-01

This study investigated the basic knowledge levels of teacher candidates' from different branches regarding the subjects of radiation and radioactivity. 42 variables were determined in relation to the specified titles. In the preparation stage of determining the variables, all the related programs were examined, and attention was paid to include…

Pulsed neutron well logging apparatus having means for determining background radiation

International Nuclear Information System (INIS)

Randall, R.R.

1979-01-01

A neutron generator in a well logging instrument is periodically pulsed and has an off period between pulses of 1000 microseconds. A neutron detector is gated on at intervals of 400 to 500, 550 to 650, and 700 to 800 microseconds, respectively, following the termination of each burst of fast neutrons. Circuitry is provided for determining the background radiation and for determining the macroscopic absorption. 3 claims

Determination of transmission factors for beta radiation at different experimental conditions

International Nuclear Information System (INIS)

Albuquerque, M. da P.P.; Caldas, L.V.E.

1988-06-01

During the transmission factors determination of beta radiation in air, using an ionization chamber with variable volume (extrapolation chamber), connected to a digital electrometer, and the secondary standard system constituted by the 90 Sr + 90 Y, 204 Tl and 147 Pm sources, the positioning of absorber materials equivalent to tissue, in relation to the detector and to the radiation sources is fundamental. In this work the absorbers were positioned in front of the sources, as well in front of the chamber, in different experiments, and the data were compared. (author) [pt

Views on reform and strengthening of the nuclear energy administrative structure

International Nuclear Information System (INIS)

Anon.

1976-01-01

Views of the Study Group on Nuclear Energy Administration, submitted to Prime Minister, are presented, concerning reform and strengthening of the administrative structure. They are based on the ideas of peaceful use, essential energy source, safety and administrative unification. Described are the following: Atomic Energy Commission, safeguard inspection/permission, examinations report, environmental radiation monitoring, public heating, universities relation, and radiation injuries prevention. (Mori, K.)

A Novel Scheme for Optimal Control of a Nonlinear Delay Differential Equations Model to Determine Effective and Optimal Administrating Chemotherapy Agents in Breast Cancer.

Science.gov (United States)

Ramezanpour, H R; Setayeshi, S; Akbari, M E

2011-01-01

Determining the optimal and effective scheme for administrating the chemotherapy agents in breast cancer is the main goal of this scientific research. The most important issue here is the amount of drug or radiation administrated in chemotherapy and radiotherapy for increasing patient's survival. This is because in these cases, the therapy not only kills the tumor cells, but also kills some of the healthy tissues and causes serious damages. In this paper we investigate optimal drug scheduling effect for breast cancer model which consist of nonlinear ordinary differential time-delay equations. In this paper, a mathematical model of breast cancer tumors is discussed and then optimal control theory is applied to find out the optimal drug adjustment as an input control of system. Finally we use Sensitivity Approach (SA) to solve the optimal control problem. The goal of this paper is to determine optimal and effective scheme for administering the chemotherapy agent, so that the tumor is eradicated, while the immune systems remains above a suitable level. Simulation results confirm the effectiveness of our proposed procedure. In this paper a new scheme is proposed to design a therapy protocol for chemotherapy in Breast Cancer. In contrast to traditional pulse drug delivery, a continuous process is offered and optimized, according to the optimal control theory for time-delay systems.

MO-E-BRE-01: Determination, Minimization and Communication of Uncertainties in Radiation Therapy

International Nuclear Information System (INIS)

Van Dyk, J; Palta, J; Bortfeld, T; Mijnheer, B

2014-01-01

Medical Physicists have a general understanding of uncertainties in the radiation treatment process, both with respect to dosimetry and geometry. However, there is a desire to be more quantitative about uncertainty estimation. A recent International Atomic Energy Agency (IAEA) report (about to be published) recommends that we should be as “accurate as reasonably achievable, technical and biological factors being taken into account”. Thus, a single recommendation as a goal for accuracy in radiation therapy is an oversimplification. That report also suggests that individual clinics should determine their own level of uncertainties for their specific treatment protocols. The question is “how do we implement this in clinical practice”? AAPM Monograph 35 (2011 AAPM Summer School) addressed many specific aspects of uncertainties in each of the steps of a course of radiation treatment. The intent of this symposium is: (1) to review uncertainty considerations in the entire radiation treatment process including uncertainty determination for each step and uncertainty propagation for the total process, (2) to consider aspects of robust optimization which optimizes treatment plans while protecting them against uncertainties, and (3) to describe various methods of displaying uncertainties and communicating uncertainties to the relevant professionals. While the theoretical and research aspects will also be described, the emphasis will be on the practical considerations for the medical physicist in clinical practice. Learning Objectives: To review uncertainty determination in the overall radiation treatment process. To consider uncertainty modeling and uncertainty propagation. To highlight the basic ideas and clinical potential of robust optimization procedures to generate optimal treatment plans that are not severely affected by uncertainties. To describe methods of uncertainty communication and display

MO-E-BRE-01: Determination, Minimization and Communication of Uncertainties in Radiation Therapy

Energy Technology Data Exchange (ETDEWEB)

Van Dyk, J; Palta, J; Bortfeld, T; Mijnheer, B [Western University, London, ON (United Kingdom)

2014-06-15

Medical Physicists have a general understanding of uncertainties in the radiation treatment process, both with respect to dosimetry and geometry. However, there is a desire to be more quantitative about uncertainty estimation. A recent International Atomic Energy Agency (IAEA) report (about to be published) recommends that we should be as “accurate as reasonably achievable, technical and biological factors being taken into account”. Thus, a single recommendation as a goal for accuracy in radiation therapy is an oversimplification. That report also suggests that individual clinics should determine their own level of uncertainties for their specific treatment protocols. The question is “how do we implement this in clinical practice”? AAPM Monograph 35 (2011 AAPM Summer School) addressed many specific aspects of uncertainties in each of the steps of a course of radiation treatment. The intent of this symposium is: (1) to review uncertainty considerations in the entire radiation treatment process including uncertainty determination for each step and uncertainty propagation for the total process, (2) to consider aspects of robust optimization which optimizes treatment plans while protecting them against uncertainties, and (3) to describe various methods of displaying uncertainties and communicating uncertainties to the relevant professionals. While the theoretical and research aspects will also be described, the emphasis will be on the practical considerations for the medical physicist in clinical practice. Learning Objectives: To review uncertainty determination in the overall radiation treatment process. To consider uncertainty modeling and uncertainty propagation. To highlight the basic ideas and clinical potential of robust optimization procedures to generate optimal treatment plans that are not severely affected by uncertainties. To describe methods of uncertainty communication and display.

Cadmium distribution and selected tissue histology in rats following administration of cadmium chloride and/or gamma radiation

International Nuclear Information System (INIS)

Kundomal, Y.R.

1981-01-01

Sprague-Dawley rats were injected IP with CdCl 2 or distilled water, and/or given a total-body irradiation. Three lethality studies, acute Cd, chronic Cd, and acute radiation, were performed to determine the sublethal doses for the co-insult study. Lethal doses (LD 50 ) were obtained by probit analysis. Cd concentrations were determined by the atomic absorption spectrophotometry. The analysis of variance was used to test the data. LD/sub 50(30)/ values obtained for respective male and female rats were: 5.99 and 7.13 mg/kg of body wt for acute Cd; 4.25 and 5.99 mg/kg of body wt for chronic Cd; and 733 and 729 R for acute radiation. On days 1, 7 and 21 post-irradiation, rats given Cd singly or in combination with radiation showed a high accumulation and retention of metal in the liver and kidney. Then followed in order of decreasing Cd concentrations were: spleen, intestine, stomach, heart, testis, lung, blood cells, brain, and muscle. High Cd concentrations in the liver and kidney persisted over a 21-day observation period; the concentrations in the other tissues decreased, some to control values. Radiation was not an antagonist on Cd concentrations or retentions in these tissues except the heart, in which radiation contributed to the clearance of Cd. Radiation did not act as a synergistic agent on Cd concentrations or retentions in any of the tissues analyzed. Radiation singly had no morphological or physiological effects on the parameters of this study. Based on the high Cd concentrations in these tissues, histological examinations of the liver and kidney sections were made. In the high co-insult groups slight abnormalities, such as pyknotic nuclei in the liver and cellular disorganization and larger lumens in the kidney were observed

Determination of radiation exposure of humans due to dermal contact with radionuclides

International Nuclear Information System (INIS)

Pratzel, H.G.

1992-01-01

It is the aim of this research project to determine the distribution of radioactive substances in the skin and organism, in order to be able to predict from these data the radiation exposure to be expected following contamination of the skin with radionuclides. Further investigations are to be carried out into the suitability of measures of prevention and decontamination. In view of the fact that only small amounts of those compounds are absorbed by the skin, the determination of the parameters chosen was carried out in radionuclide studies in young pigs. With the exception of the skin of the palms and soles, the radiation effects in man could easily be extrapolated from the results of these experiments. The findings revealed permit the following conclusions to be drawn: The incorporation of radioactive substances after dermal contamination is quite unavoidable, even if this is immediately followed by decontamination measures. The degree of incorporation and resulting radiation dose are only minor and remain several orders of magnitude below the dermal radiation dose. If the skin is contaminated with radioactive liquids, the extent of incorporation and accumulation is proportionate to the activity concentration of those liquids. The incorporated radiation dose is in direct proportion to the contaminated skin area and also shows a relationship to the duration of contamination, if the skin is wet. The uptake by the organism may be somewhat reduced, if decontamination is initiated immediately. Dermal protectives may help to reduce skin permeability and, thus, the uptake of radioactivity into the corneal layer and follicles. (orig./MG) [de

Determination of High-Frequency Current Distribution Using EMTP-Based Transmission Line Models with Resulting Radiated Electromagnetic Fields

Energy Technology Data Exchange (ETDEWEB)

Mork, B; Nelson, R; Kirkendall, B; Stenvig, N

2009-11-30

Application of BPL technologies to existing overhead high-voltage power lines would benefit greatly from improved simulation tools capable of predicting performance - such as the electromagnetic fields radiated from such lines. Existing EMTP-based frequency-dependent line models are attractive since their parameters are derived from physical design dimensions which are easily obtained. However, to calculate the radiated electromagnetic fields, detailed current distributions need to be determined. This paper presents a method of using EMTP line models to determine the current distribution on the lines, as well as a technique for using these current distributions to determine the radiated electromagnetic fields.

Experimental determination of radiated internal wave power without pressure field data

Science.gov (United States)

Lee, Frank M.; Paoletti, M. S.; Swinney, Harry L.; Morrison, P. J.

2014-04-01

We present a method to determine, using only velocity field data, the time-averaged energy flux left and total radiated power P for two-dimensional internal gravity waves. Both left and P are determined from expressions involving only a scalar function, the stream function ψ. We test the method using data from a direct numerical simulation for tidal flow of a stratified fluid past a knife edge. The results for the radiated internal wave power given by the stream function method agree to within 0.5% with results obtained using pressure and velocity data from the numerical simulation. The results for the radiated power computed from the stream function agree well with power computed from the velocity and pressure if the starting point for the stream function computation is on a solid boundary, but if a boundary point is not available, care must be taken to choose an appropriate starting point. We also test the stream function method by applying it to laboratory data for tidal flow past a knife edge, and the results are found to agree with the direct numerical simulation. The supplementary material includes a Matlab code with a graphical user interface that can be used to compute the energy flux and power from two-dimensional velocity field data.

Experimental determination of radiated internal wave power without pressure field data

International Nuclear Information System (INIS)

Lee, Frank M.; Morrison, P. J.; Paoletti, M. S.; Swinney, Harry L.

2014-01-01

We present a method to determine, using only velocity field data, the time-averaged energy flux (J) and total radiated power P for two-dimensional internal gravity waves. Both (J) and P are determined from expressions involving only a scalar function, the stream function ψ. We test the method using data from a direct numerical simulation for tidal flow of a stratified fluid past a knife edge. The results for the radiated internal wave power given by the stream function method agree to within 0.5% with results obtained using pressure and velocity data from the numerical simulation. The results for the radiated power computed from the stream function agree well with power computed from the velocity and pressure if the starting point for the stream function computation is on a solid boundary, but if a boundary point is not available, care must be taken to choose an appropriate starting point. We also test the stream function method by applying it to laboratory data for tidal flow past a knife edge, and the results are found to agree with the direct numerical simulation. The supplementary material includes a Matlab code with a graphical user interface that can be used to compute the energy flux and power from two-dimensional velocity field data

Functional size of photosynthetic electron transport chain determined by radiation inactivation

International Nuclear Information System (INIS)

Pan, R.S.; Chen, L.F.; Wang, M.Y.; Tsal, M.Y.; Pan, R.L.; Hsu, B.D.

1987-01-01

Radiation inactivation technique was employed to determine the functional size of photosynthetic electron transport chain of spinach chloroplasts. The functional size for photosystem I+II(H 2 O to methylviologen) was 623 +/- 37 kilodaltons; for photosystem II (H 2 O to dimethylquinone/ferricyanide), 174 +/- 11 kilodaltons; and for photosystem I (reduced diaminodurene to methylviologen), 190 +/- 11 kilodaltons. The difference between 364 +/- 22 (the sum of 174 +/- 11 and 190 +/- 11) kilodaltons and 623 +/- 37 kilodaltons is partially explained to be due to the presence of two molecules of cytochrome b 6 /f complex of 280 kilodaltons. The molecular mass for other partial reactions of photosynthetic electron flow, also measured by radiation inactivation, is reported. The molecular mass obtained by this technique is compared with that determined by other conventional biochemical methods. A working hypothesis for the composition, stoichiometry, and organization of polypeptides for photosynthetic electron transport chain is proposed

Radiation load in determining bone age

International Nuclear Information System (INIS)

Totsev, N.; Gylybova, V.

1991-01-01

The determination of the bone age in children is based on X-ray of the left wrist. By means of the dosimetric device 'Robotron 2300' it is shown that the average surface dose for single X-ray is about 49.10 5 Gy. The execution of single X-ray is well-grounded and the conditions for it are specified: blending of the object and shielding of the gonads and the whole body with a lead rubber as well as immobilizing of the hand with a specially made appliance. The risk of radiation injury during the study is practically negligible. Having in mind the significance of the problems which could be solved using the results of such a study, the benefit/harm relationship is in favour of broader use of the method. 12 refs., 1tab. described

Determining optical and radiation characteristics of cathode ray tubes' glass to be reused as radiation shielding glass

Science.gov (United States)

Zughbi, A.; Kharita, M. H.; Shehada, A. M.

2017-07-01

A new method of recycling glass of Cathode Ray Tubes (CRTs) has been presented in this paper. The glass from CRTs suggested being used as raw materials for the production of radiation shielding glass. Cathode ray tubes glass contains considerable amounts of environmentally hazardous toxic wastes, namely heavy metal oxides such as lead oxide (PbO). This method makes CRTs glass a favorable choice to be used as raw material for Radiation Shielding Glass and concrete. The heavy metal oxides increase its density, which make this type of glass nearly equivalent to commercially available shielding glass. CRTs glass have been characterized to determine heavy oxides content, density, refractive index, and radiation shielding properties for different Gamma-Ray energies. Empirical methods have been used by using the Gamma-Ray source cobalt-60 and computational method by using the code XCOM. Measured and calculated values were in a good compatibility. The effects of irradiation by gamma rays of cobalt-60 on the optical transparency for each part of the CRTs glass have been studied. The Results had shown that some parts of CRTs glass have more resistant to Gamma radiation than others. The study had shown that the glass of cathode ray tubes could be recycled to be used as radiation shielding glass. This proposed use of CRT glass is only limited to the available quantity of CRT world-wide.

Determination of tin equilibrium isotope fractionation factors from synchrotron radiation experiments

NARCIS (Netherlands)

Polyakov, VB; Mineev, SD; Clayton, RN; Hu, G; Mineev, KS

2005-01-01

A method of determination of the reduced isotopic partition function ratio (beta-factor) from the partial density of state (PDOS) obtained by inelastic nuclear resonant X-ray scattering (INRXS) in synchrotron radiation experiments has been established. The method has been demonstrated by the example

Administrative-legal regulation of causes and conditions determining corruption in social sphere

Directory of Open Access Journals (Sweden)

Aleksandr V. Polukarov

2017-12-01

sphere and gives their classification according to certain criteria. Basing on the study the proposals are formulated aimed at improving implementation of administrative and legal measures influencing the causes and conditions that determine corruption in the social sphere. Practical significance the proposed legal and administrative means enable to form the administrativelegal regime aimed at minimizing the causes and conditions that determine corruption in the social sphere.

Radiation practices and radiation measurements

International Nuclear Information System (INIS)

2008-03-01

The guide presents the principal requirements on accuracy of radiation measurements and on the approval, calibration and operating condition inspections of radiation meters, together with requirements for dosimetric services measuring the individual radiation doses of workers engaged in radiation work (approved dosimetric services). The Guide also sets out the definitions of quantities and units used in radiation measurements. The radiation protection quantities used for assessing the harmful effects of radiation and for expressing the maximum values for radiation exposure (equivalent dose and effective dose) are set out in Guide ST 7.2. This Guide concerns measurements of ionizing radiation involved in radiation practices, the results of which are used for determining the radiation exposure of workers engaged in radiation work and members of the public, and of patients subject to the use of radiation in health services, or upon the basis of which compliance with safety requirements of appliances currently in use and of their premises of use or of the workplaces of workers is ensured. The Guide also concerns measurements of the radon concentration of inhaled air in both workplaces and dwellings. The Guide does not apply to determining the radiation exposure of aircrews, determination of exposure caused by internal radiation, or measurements made to protect the public in the event of, or in preparation for abnormal radiation conditions

Experimental Determination of the Neutron Radiation-Dose Distribution in the Human Phantom

Energy Technology Data Exchange (ETDEWEB)

Stipcic, Neda [Institute Rudjer Bogkovic, Zagreb, Yugoslavia (Serbia)

1967-01-15

The quality of the radiation delivering the radiation dose to the human phantom is quite different from that of the incident neutron beam. This paper describes the experimental investigation of the variation of neutron dose related to the variation of neutron fluence with depth in the human phantom. The distribution of neutron radiation was determined in the human phantom - a cube of paraffin wax 25 cm x 25 cm x 50 cm with a density of 0.92 cm{sup -3}. Po-Be and Ra-Be point sources were used as neutron sources. Neutron fluences were measured using different types of detector: scintillation detector, BF{sub 3} counter, and nuclear-track emulsions. Since the fluence measurements with these three types of detectors were carried out under the same experimental conditions, it was possible to separate and analyse each part of the radiation dose in the paraffin. From the investigations, the distribution of the total radiation dose was obtained as a function of the paraffin depth. The maximum value of this dose distribution is constant with respect to the distance between the source and the paraffin phantom. From the results obtained, some conclusions may be drawn concerning the amount of absorbed radiation dose in the human phantom. (author)

Determination of possible radiation hazards associated with tin mining industry in West Malaysia

International Nuclear Information System (INIS)

Hu, S.J.

1979-04-01

A study was made in Malaysia under an IAEA research contract on the possible radiation hazards associated with tin mining industry in Malaysia. The study comprised of the measurement of external radiation levels in various mines, gamma-ray spectrometric analysis of various samples from mines, and measurements of radon and radon daughters concentrations. For radon daughters modified Tsivoglou and Kusnetz methods were used. The study showed that there is, in general, no radiation hazard associated with the tin mining industry in West Malaysia. However, the only likely source that might pose some external radiation hazard is the amang upgrading plant which invariably concentrates either or both 232 Th and 238 U in the final products of the upgrading process. A quantitative and thorough investigation of radiation levels in the amang upgrading industry is necessary to determine the degree of hazard. No significant radon or radon daughters concentrations were noted in the underground mines

Radiation exposure management

International Nuclear Information System (INIS)

Snihs, J.O.

1985-01-01

Radiation exposure management includes administrative control, education and training, monitoring and dose assessments and planning of work and radiation protection. The information and discussion given in the paper are based on experiences in Sweden mainly from nuclear power installations. (Author)

Research activities in radiation protection. Programme report 1997. Report on the departmental research programme of the Federal Ministry for Environment, Nature Conservation and Reactor Safety (BMU), performed under the scientific and administrative project management of the Federal Office for Radiation Protection (BfS)

International Nuclear Information System (INIS)

Schmitt-Hannig, A.; Goedde, R.; Thieme, M.

1998-03-01

On behalf of the Federal Ministry for Environment, Nature Conservation and Nuclear Safety (BMU), the Federal Office for Radiation Protection (BfS) is placing research and study contracts in the field of radiation protection. The results of these projects are used for developing radiation protection rules and to fulfill the special radiation protection tasks of the BMU, required by law. Planning, expert and administrative management, placing, assistance as well as expert evaluation of the results from these research projects lies within the responsibility of the Federal Office for Radiation Protection. This report provides information on preliminary and final results of radiation protection projects within the BMU Departmental Research Programme of the year 1997. (orig.) [de

Research activities in radiation protection. Programme report 1996. Report on the departmental research programme of the Federal Ministry for Environment, Nature Conservation and Reactor Safety (BMU), performed under the scientific and administrative project management of the Federal Office for Radiation Protection (BfS)

International Nuclear Information System (INIS)

Schmitt-Hannig, A.; Thieme, M.; Goedde, R.

1997-02-01

On behalf of the Ministry for Environment, Nature Conservation and Nuclear Safety (BMU), the Federal Office for Radiation Protection is placing research and study contracts in the field of radiation protection. The results of these projects are used for developing radiation protection rules and to fulfill the special radiation protection tasks of the BMU, required by law. Planning, expert and administrative management, placing, assistance as well as expert evaluation of the results from these research projects lies within the responsibility of the Federal Office for Radiation Protection. This report provides information on preliminary and final results of radiation protection projects within the BMU Department Research Programme of the year 1996. (orig.) [de

The effect of clear sky radiation on crop surface temperature determined by thermal thermometry

International Nuclear Information System (INIS)

Svendsen, H.; Jensen, H.E.; Jensen, S.E.; Mogensen, V.O.

1990-01-01

By numerical integration of Planck's radiation function, a relationship between emitted radiation from a black body in the wavelength band 8–14 μm and the corresponding surface temperature was obtained. Using this relationship, an equation was developed relating the temperature error at different temperatures to the crop surface emissivity and clear sky radiation. It is concluded that the temperature error to be expected from neglect of clear sky radiation in the wavelength band 8–14μm in radiometric crop surface temperature determination is < 0.2 and 0.1 °C for crops with an emissivity > 0.96 and 0.98, respectively, for a leaf temperature range from 0 to 30°C

Determining optical and radiation characteristics of cathode ray tubes' glass to be reused as radiation shielding glass

International Nuclear Information System (INIS)

Zughbi, A.; Kharita, M.H.; Shehada, A.M.

2017-01-01

A new method of recycling glass of Cathode Ray Tubes (CRTs) has been presented in this paper. The glass from CRTs suggested being used as raw materials for the production of radiation shielding glass. Cathode ray tubes glass contains considerable amounts of environmentally hazardous toxic wastes, namely heavy metal oxides such as lead oxide (PbO). This method makes CRTs glass a favorable choice to be used as raw material for Radiation Shielding Glass and concrete. The heavy metal oxides increase its density, which make this type of glass nearly equivalent to commercially available shielding glass. CRTs glass have been characterized to determine heavy oxides content, density, refractive index, and radiation shielding properties for different Gamma-Ray energies. Empirical methods have been used by using the Gamma-Ray source cobalt-60 and computational method by using the code XCOM. Measured and calculated values were in a good compatibility. The effects of irradiation by gamma rays of cobalt-60 on the optical transparency for each part of the CRTs glass have been studied. The Results had shown that some parts of CRTs glass have more resistant to Gamma radiation than others. The study had shown that the glass of cathode ray tubes could be recycled to be used as radiation shielding glass. This proposed use of CRT glass is only limited to the available quantity of CRT world-wide. - Highlights: • A new method of recycling glass of Cathode Ray Tubes (CRTs) has been presented. • The glass from CRTs used as raw materials for radiation shielding glass. • The resulted glass have good optical properties and stability against radiations.

26 CFR 1.414(r)-6 - Qualified separate line of business-administrative scrutiny requirement-individual determinations.

Science.gov (United States)

2010-04-01

...-administrative scrutiny requirement-individual determinations. 1.414(r)-6 Section 1.414(r)-6 Internal Revenue... Pension, Profit-Sharing, Stock Bonus Plans, Etc. § 1.414(r)-6 Qualified separate line of business... determined under § 1.414(r)-3) that does not satisfy any of the safe harbors in § 1.414(r)-5 for a testing...

Radioprotective effects of natural β-carotene on villi and crypts in abdominally radiated mice

International Nuclear Information System (INIS)

Kurabe, Teruhisa; Itoh, Youko; Matsumura, Eijin; Nakamura, Atsushi; Ayakawa, Yoshio

2002-01-01

The protective effect of β-carotene against radiation injury to the small intestine of abdominally radiated mice (15 Gy) was examined with administration given pre-radiation, during (pre- and post-) radiation, and post-radiation. In the β-carotene group, the ratio of villus length to crypt was significantly greater in comparison with the radiation only group at 2 days after radiation. At 7 days after radiation, the ratio of necrotic cells in the crypt vs. the total was significantly lower, and the ratio of necrotic cells in the villus vs. the total was significantly greater with β-carotene administration, which indicated that β-carotene accelerated recovery from radiation injury. Each group administered β-carotene showed a significant radioprotective effect, with pre-radiation administration yielding a smaller effect than administration during radiation and post-radiation. It is concluded that pre-, during, and post-radiation administration of β-carotene protected against radiation injury of the small intestine and accelerated recovery from it. (author)

New England States environmental radiation surveillance programs

International Nuclear Information System (INIS)

Molloy, E.J.

1980-01-01

An overview of the environmental radiation surveillance programs in the New England States from the viewpoint of their organization and administration is provided. Moreover, the specific monitoring and analytical programs conducted at selected sites in each state is detailed with emphasis on sample types, collection frequencies, and analysis. Also, a comparison is made between the programs of all the states in order to determine the reasons for their differences

Process and appliance for determining the nature of transported substances by measuring the radiations transmitted

International Nuclear Information System (INIS)

Wykes, J.S.; Surzyn, P.M.; Croke, G.M.; Adsley, Ian.

1980-01-01

The invention relates to a process for determining the nature of a substance transported, comprising the collimation of the radiation of not less than two energies so that they form beams; the irradiation of the matter transported by the beams, the detection of the non-scattered radiations for the two energies at least, after passing in the transported matter, and the deduction of the nature of the transported matter according to the radiations detected. The radiations are collimated by placing a shield around the gamma source (americium 241 or cesium 137). The detector is protected by a shield so that it prevents any significant interference due to the reactions near the surface provoked by those radiations not of the lowest energy, with detection of those radiations of lesser energy. In a variation, a source of relatively higher energy radiations is placed at a distance from the source of relatively lesser energy radiations. The latter have a component taken from natural ionizing radiation and this component is withdrawn to a predetermined calibration [fr

Ukraine International cooperation in nuclear and radiation safety: public-administrative aspect

Directory of Open Access Journals (Sweden)

I. P. Krynychnay

2017-03-01

Full Text Available The article examines international cooperation of Ukraine with other States in the sphere of ensuring nuclear and radiation safety and highlights the main directions of development and improvement of nuclear and radiation safety in Ukraine based on international experience, with the aim of preventing the risks of accidents and contamination areas radiological substances. Illuminated that for more than half a century of experience in the use of nuclear energy by the international community under the auspices of the UN, IAEA and other international organizations initiated and monitored the implementation of key national and international programs on nuclear and radiation safety. Of the Convention in the field of nuclear safety and the related independent peer review, effective national regulatory infrastructures, current nuclear safety standards and policy documents, as well as mechanisms of evaluation in the framework of the IAEA constitute important prerequisites for the creation of a world community, the global regime of nuclear and radiation safety. For analysis of the state of international cooperation of Ukraine with other States in the sphere of nuclear and radiation safety, highlighted the legal substance of nuclear and radiation safety of Ukraine, which is enshrined in the domestic Law of Ukraine «On nuclear energy use and radiation safety». Considered the most relevant legal relations. It is established that, despite the current complex international instruments, existing domestic legislation on nuclear and radiation safety, partly there is a threat of emergency nuclear radiation nature, in connection with the failure of fixed rules and programs, lack of funding from the state is not always on time and in full allows you to perform fixed strategy for overcoming the consequences of radiation accidents, the prevention of the threat of environmental pollution. Found that to improve and further ensuring nuclear and radiation safety of

Handling technique of spore-forming bacteria in radiation sterilization. 2. Determination of numbers and radiation resistance of spores

International Nuclear Information System (INIS)

Koshikawa, Tomihiko

1994-01-01

Stepwise ten-fold dilution of bacterial solution is required in the determination of bacterial spores. For this, the selection of diluted solution is important according to the purpose of experiment. First, the preparation of suspension of bacterial spores and selection of diluted solution are presented. Then, a method for determining the number of bacterial spores in materials is outlined in terms of dilution methods of bacterial solution (shaking and homogenization) and application method of diluted solution to the plating medium. Finally, a method for determining radiation resistance of spore-forming bacteria is explained according to the measurement conditions (suspension of bacterial spores and filters applied with bacterial spores). (N.K.)

Handling technique of spore-forming bacteria in radiation sterilization. 2. Determination of numbers and radiation resistance of spores

Energy Technology Data Exchange (ETDEWEB)

Koshikawa, Tomihiko [Japan Radioisotope Association, Shiga (Japan). Koka Laboratory

1994-12-01

Stepwise ten-fold dilution of bacterial solution is required in the determination of bacterial spores. For this, the selection of diluted solution is important according to the purpose of experiment. First, the preparation of suspension of bacterial spores and selection of diluted solution are presented. Then, a method for determining the number of bacterial spores in materials is outlined in terms of dilution methods of bacterial solution (shaking and homogenization) and application method of diluted solution to the plating medium. Finally, a method for determining radiation resistance of spore-forming bacteria is explained according to the measurement conditions (suspension of bacterial spores and filters applied with bacterial spores). (N.K.).

Can coherent Smith-Purcell radiation be used to determine the shape of an electron bunch?

International Nuclear Information System (INIS)

Doria, A.; Gallerano, G.P.; Giovenale, E.; Messina, G.; Doucas, G.; Kimmitt, M.F.; Andrews, H.L.; Brownell, J.H.

2002-01-01

Recent measurements at Frascati of the Smith-Purcell radiation emitted from the interaction of a 2.3 MeV (total) electron beam with a 2.5 mm grating show clear evidence of coherent enhancement of the radiation, with power levels exceeding 100 mW at emission angles around 90 deg. relative to the beam direction. The experimental results are in reasonable agreement with theoretical predictions and suggest that Smith-Purcell radiation may offer a simple way of determining the shape and duration of short (picosecond) electron bunches

Determining the temperature and density distribution from a Z-pinch radiation source

International Nuclear Information System (INIS)

Matuska, W.; Lee, H.

1997-01-01

High temperature radiation sources exceeding one hundred eV can be produced via z-pinches using currently available pulsed power. The usual approach to compare the z-pinch simulation and experimental data is to convert the radiation output at the source, whose temperature and density distributions are computed from the 2-D MHD code, into simulated data such as a spectrometer reading. This conversion process involves a radiation transfer calculation through the axially symmetric source, assuming local thermodynamic equilibrium (LTE), and folding the radiation that reaches the detector with the frequency-dependent response function. In this paper the authors propose a different approach by which they can determine the temperature and density distributions of the radiation source directly from the spatially resolved spectral data. This unfolding process is reliable and unambiguous for the ideal case where LTE holds and the source is axially symmetric. In reality, imperfect LTE and axial symmetry will introduce inaccuracies into the unfolded distributions. The authors use a parameter optimization routine to find the temperature and density distributions that best fit the data. They know from their past experience that the radiation source resulting from the implosion of a thin foil does not exhibit good axial symmetry. However, recent experiments carried out at Sandia National Laboratory using multiple wire arrays were very promising to achieve reasonably good symmetry. For these experiments the method will provide a valuable diagnostic tool

Photoacoustic Determination of Non-radiative Relaxation Time of Absorbing Centers in Maize Seeds

Science.gov (United States)

Domínguez-Pacheco, A.; Hernández-Aguilar, C.; Cruz-Orea, A.

2017-07-01

Using non-destructive photothermal techniques, it is possible to characterize non-homogenous materials to obtain its optical and thermal properties through photoacoustic spectroscopy (PAS). In photoacoustic (PA) phenomena, there are transient states of thermal excitation, when samples absorb the incident light; these states manifest an excitation process that generates the PA signal, being in direct relation with the non-radiative relaxation times with the sample absorbent centers. The objective of this study was to determine the non-radiative relaxation times associated with different absorbent centers of corn seeds ( Zea mays L.), by using PAS. A frequency scan was done at different wavelengths (350 nm, 470 nm and 650 nm) in order to obtain the non-radiative relaxation times with different types of maize seeds.

Protective effects of melatonin on damage of thymocytes in mice induced by ionizing radiation

International Nuclear Information System (INIS)

Zhang Xuan; Wang Zhenqi; Liu Yang; Gong Shouliang; Zhang Ming; Liu Shuzheng

2004-01-01

Objective: To explore the effects of melatonin (MLT) on the damage of mouse thymocytes in vivo induced by ionizing radiation and its mechanism. Methods: The exogenous MLT was given to Kunming mice to establish the animal models of single and successive administration of MLT through intraperitoneal injection before whole-body irradiation with 1 Gy X-rays. For single administration of MLT, the apoptotic body percentage (ABP) and DNA lytic rate (DLR) in the thymocytes were determined with flow cytometry and fluorospectrophotometry, respectively, 12 h after irradiation. For successive administration of MLT, 3 H-TdR incorporative rate (HTIR ) was determined 24 h after irradiation. Results: The number of thymocytes in single administration group was significantly lower than that in the sham-irradiation group 12 h after irradiation with 1 Gy X-rays (P -1 MLT group was significantly higher, while the ABP and DLR were significantly lower than those in 0 mg·kg -1 MLT group (simple irradiation, P -1 MLT were significantly higher than that in 0 mg·kg -1 MLT group (P -1 MLT group was also significantly higher (P<0.05). Conclusion: The administration of exogenous MLT before irradiation can decrease the damage of mouse thymocytes induced by ionizing radiation, and has the protective effect on immune functions in mice. (authors)

X-ray spectral determination by detection of radiation scattered at different angles

International Nuclear Information System (INIS)

Barrea, Raul; Mainardi, R.T.

1987-01-01

A precise knowledge of the spectral content of an X-ray beam is of fundamental importance in areas such as X-ray fluorescence analysis by absolute methods, radiodiagnosis, radiotherapy, computed tomography, etc. A simple practical method was developed to determine X-ray spectra emitted by X-ray tubes. It is based on the scattering of the beam on a solid target and detection of this radiation at different angles. This methodology can easily be adapted to the successive attenuation of the beam procedure. Numerical parameter values of a proposed analytical function for the energy spectrum are found measuring the radiation intensity with a suitable detector (ionization chamber or plastic scintillation detector) and equating it with the convolution integral of the proposed spectrum with the incoherent scattering function. This procedure of spectra determination is enclosed in the same group of those generically referred as successive modifications of the irradiation set up used in absolute methods of X-ray fluorescence analysis. (Author) [es

Regulation on Radiation Safety of Guatemala

International Nuclear Information System (INIS)

2001-03-01

This regulation includes all the requirements administrative, radiation protection, that licensees must meet in order to obtain authorization from the competent authority to apply and use radiation sources, equipment emiting ionizing radiation in different practices authorized

Virtual radiation fields for ALARA determination

International Nuclear Information System (INIS)

Knight, T.W.

1995-01-01

As computing power has increased, so too has the ability to model and simulate complex systems and processes. In addition, virtual reality technology has made it possible to visualize and understand many complex scientific and engineering problems. For this reason, a virtual dosimetry program called Virtual Radiation Fields (VRF) is developed to model radiation dose rate and cumulative dose to a receptor operating in a virtual radiation environment. With the design and testing of many facilities and products taking place in the virtual world, this program facilitates the concurrent consideration of radiological concerns during the design process. Three-dimensional (3D) graphical presentation of the radiation environment is made possible through the use of IGRIP, a graphical modeling program developed by Deneb Robotics, Inc. The VRF simulation program was designed to model and display a virtual dosimeter. As a demonstration of the program's capability, the Hanford tank, C-106, was modeled to predict radiation doses to robotic equipment used to remove radioactive waste from the tank. To validate VRF dose predictions, comparison was made with reported values for tank C-106, which showed agreement to within 0.5%. Graphical information is presented regarding the 3D dose rate variation inside the tank. Cumulative dose predictions were made for the cleanup operations of tank C-106. A four-dimensional dose rate map generated by VRF was used to model the dose rate not only in 3D space but also as a function of the amount of waste remaining in the tank. This allowed VRF to predict dose rate at any stage in the waste removal process for an accurate simulation of the radiological conditions throughout the tank cleanup procedure

Teachers' and Administrators' Perceptions of Knowledge Management Competence of High School Administrators

Science.gov (United States)

Memisoglu, Salih Pasa

2016-01-01

This study aims to determine the teachers' and administrators' perceptions of knowledge management competence in high school administration. The study was conducted using the screening model and the study group consisted of 162 teachers and 35 administrators working at eight high schools in Turkey. Administrators' knowledge management competence…

Survey of Canadian hospitals radiation emergency plans

Energy Technology Data Exchange (ETDEWEB)

Davis, C [Social Data Research Ltd./The Flett Consulting Group, Inc., Ottawa, ON (Canada)

1996-02-01

This report documents the findings of a survey of Canadian hospitals conducted by Social Data Research Ltd. during the Spring and Summer, 1995. The main objective of the survey was to determine the state of readiness of Canadian hospitals in respect of radiation emergency planning. In addition, the AECB was interested in knowing the extent to which a report by the Group of Medical Advisors, `GMA-3: Guidelines on Hospital Emergency Plans for the Management of Minor Radiation Accidents`, which was sponsored and distributed in 1993, was received and was useful to hospital administrators and emergency personnel. A self-administered questionnaire was distributed to 598 acute care hospitals, and 274 responses were received. The main conclusion of this study is that, with the exception of a few large institutions, hospitals generally do not have specific action plans to handle minor radiation accidents. (author).

Survey of Canadian hospitals radiation emergency plans

International Nuclear Information System (INIS)

Davis, C.

1996-02-01

This report documents the findings of a survey of Canadian hospitals conducted by Social Data Research Ltd. during the Spring and Summer, 1995. The main objective of the survey was to determine the state of readiness of Canadian hospitals in respect of radiation emergency planning. In addition, the AECB was interested in knowing the extent to which a report by the Group of Medical Advisors, 'GMA-3: Guidelines on Hospital Emergency Plans for the Management of Minor Radiation Accidents', which was sponsored and distributed in 1993, was received and was useful to hospital administrators and emergency personnel. A self-administered questionnaire was distributed to 598 acute care hospitals, and 274 responses were received. The main conclusion of this study is that, with the exception of a few large institutions, hospitals generally do not have specific action plans to handle minor radiation accidents. (author)

Measurements of the ionising radiation level at a nuclear medicine facility performing PET/CT examinations

International Nuclear Information System (INIS)

Tulik, P.; Kowalska, M.; Golnik, N.; Budzynska, A.; Dziuk, M.

2017-01-01

This paper presents the results of radiation level measurements at workplaces in a nuclear medicine facility performing PET/ CT examinations. This study meticulously determines the staff radiation exposure in a PET/CT facility by tracking the path of patient movement. The measurements of the instantaneous radiation exposure were performed using an electronic radiometer with a proportional counter that was equipped with the option of recording the results on line. The measurements allowed for visualisation of the staff's instantaneous exposure caused by a patient walking through the department after the administration of "1"8F-FDG. An estimation of low doses associated with each working step and the exposure during a routine day in the department was possible. The measurements were completed by determining the average radiation level using highly sensitive thermoluminescent detectors. (authors)

Modeling Space Radiation with Bleomycin

Data.gov (United States)

National Aeronautics and Space Administration — Space radiation is a mixed field of solar particle events (proton) and particles of Galactic Cosmic Rays (GCR) with different energy levels. These radiation events...

Radiation Hazard Detector

Science.gov (United States)

1978-01-01

NASA technology has made commercially available a new, inexpensive, conveniently-carried device for protection, of people exposed to potentially dangerous levels of microwave radiation. Microwaves are radio emissions of extremely high frequency. They can be hazardous but the degree of hazard is not yet well understood. Generally, it is believed that low intensity radiation of short duration is not harmful but that exposure to high levels can induce deep internal burns, affecting the circulatory and nervous systems, and particularly the eyes. The Department of Labor's Occupational Safety and Health Administration (OSHA) has established an allowable safe threshold of exposure. However, people working near high intensity sources of microwave energy-for example, radar antennas and television transmitters-may be unknowingly exposed to radiation levels beyond the safe limit. This poses not only a personal safety problem but also a problem for employers in terms of productivity loss, workman's compensation claims and possible liability litigation. Earlier-developed monitoring devices which warn personnel of dangerous radiation levels have their shortcomings. They can be cumbersome and awkward to use while working. They also require continual visual monitoring to determine if a person is in a dangerous area of radiation, and they are relatively expensive, another deterrent to their widespread adoption. In response to the need for a cheaper and more effective warning system, Jet Propulsion Laboratory developed, under NASA auspices, a new, battery-powered Microwave Radiation Hazard Detector. To bring the product to the commercial market, California Institute Research Foundation, the patent holder, granted an exclusive license to Cicoil Corporation, Chatsworth, California, an electronic components manufacturer.

7 CFR 12.6 - Administration.

Science.gov (United States)

2010-01-01

... 7 Agriculture 1 2010-01-01 2010-01-01 false Administration. 12.6 Section 12.6 Agriculture Office....6 Administration. (a) General. A determination of ineligibility for benefits in accordance with the... making such determinations, as provided in this section. (b) Administration by FSA. (1) The provisions of...

Sex-dependent response of some rat biochemical, histological and embryological features to Squalene administration or/ and gamma radiation exposure

International Nuclear Information System (INIS)

Ibrahim, M.F.; Abo-Zid, N.M.; Ahmed, A.G.

2012-01-01

Squalene, an intermediate of cholesterol biosynthesis, is known to possess potent antioxidant properties. The objective of the current study was to evaluate the influence of Squalene on some radiation-induced biochemical, histological and embryological changes in Sprague Dawley rats. Squalene was orally administered to rats (5 ml/kg/day) throughout 60 days before whole body gamma irradiation with 4 Gy. In adult male and female rats, the results revealed that Squalene has modulated the radiation produced abrupt elevation of total cholesterol (TC), triglycerides (TG) and and low density lipoprotein-cholesterol (LDL-C) levels and reduction of high density lipoprotein-cholesterol (HDL-C) ones in both male and female serum and male liver samples whereas it could not control the abrupt increase of HDL-C and decline of LDL-C in female liver values. Also Squalene has modified the histopathological acquired radiation lesions of both male and female colonic and hepatic tissues yet the female tested colonic sections showed moderate regeneration of crypts and villi layers whereas the hepatic sections yet displayed apparent hemorrhage and fatty liver infiltration of inflammatory cells. However, in the mated male rats and their pregnant counterparts, Squalene considerably restored the radiation induced male and female sex hormonal abrupt changes especially in female rats. Squalene administration to pergnant rats before irradiation at gestational day 17 improved the fetal survival ability as identified by the disappearance of resorption sites in the tested maternal uteri. Hence, it could be concluded that Squalene radioprotective capability surpassed the adult male rats than the female ones though it specified the pregnant females by protecting their growing embryos against radiation induced intrauterine fatal effect

The study of the radiation protection of propolis to the radiation effects in mice

Energy Technology Data Exchange (ETDEWEB)

Gu, Y.H.; Suzuki, Ikukatsu; Hasegawa, Takeo; Muto, H. [Suzuka Univ. of Medical Science, Mie (Japan); Yanagisawa, Takaharu; Iwasa, Toshihiro; Bamen, K.

2000-05-01

The profit which radiation brought to the Homo sapiens is very big. But, radiation has even harmful parameter for the human besides one case. After effect on man to the radiation is thought about, the individual of which sensibility is the highest is a fetus. Therefore, even an effects to this fetus is grasped precisely, and protection criterion and resource are decided from the viewpoint of the protection of radiation as well. If it does so, a child and maturitas aren't so difficult as in the protection of radiation and the managerial side. It was examined about control group, propolis administration chisels for medical use group, 1.5 Gy independent exposure group and propolis pluse 1.5 Gy group in this study. It was examined about the protection of radiation of propolis which to malformation, fetal death, arrested development, and so on in the organogenesis (8 days post conception) being done when sensibility is the highest against the teratogenesis. Preimplantation death rate was compared with the control group and the sham control group, and statistical significant difference wasn't recognized by a 1.5 Gy radiation independent exposure group, propolis administration 1.5 Gy radiation exposure group. As for the embryonic death rate, propolis was administered, and obviously embryonic death rate was poorer than the 1.5 Gy independent exposure group, and significant difference was recognized by a 1.5 Gy radiation exposure group (p<0.001). It has a 1.5 Gy radiation exposure group made clear by this research fetal death rate propolis administer more only 1.5 Gy exposure fetal death rate development low (p<0.001). Fetal death rate wasn't recognized by propolis administration group (Sham control). As for the teratogenesis rate, propolis was administered, and the teratogenesis rate of the 1.5 Gy radiation exposure group was higher than the 1.5 Gy radiation independent exposure group. But, this is thought anamorphosis appear by propolis administration so

The study of the radiation protection of propolis to the radiation effects in mice

International Nuclear Information System (INIS)

Gu, Y.H.; Suzuki, Ikukatsu; Hasegawa, Takeo; Muto, H.; Yanagisawa, Takaharu; Iwasa, Toshihiro; Bamen, K.

2000-01-01

The profit which radiation brought to the Homo sapiens is very big. But, radiation has even harmful parameter for the human besides one case. After effect on man to the radiation is thought about, the individual of which sensibility is the highest is a fetus. Therefore, even an effects to this fetus is grasped precisely, and protection criterion and resource are decided from the viewpoint of the protection of radiation as well. If it does so, a child and maturitas aren't so difficult as in the protection of radiation and the managerial side. It was examined about control group, propolis administration chisels for medical use group, 1.5 Gy independent exposure group and propolis pluse 1.5 Gy group in this study. It was examined about the protection of radiation of propolis which to malformation, fetal death, arrested development, and so on in the organogenesis (8 days post conception) being done when sensibility is the highest against the teratogenesis. Preimplantation death rate was compared with the control group and the sham control group, and statistical significant difference wasn't recognized by a 1.5 Gy radiation independent exposure group, propolis administration 1.5 Gy radiation exposure group. As for the embryonic death rate, propolis was administered, and obviously embryonic death rate was poorer than the 1.5 Gy independent exposure group, and significant difference was recognized by a 1.5 Gy radiation exposure group (p<0.001). It has a 1.5 Gy radiation exposure group made clear by this research fetal death rate propolis administer more only 1.5 Gy exposure fetal death rate development low (p<0.001). Fetal death rate wasn't recognized by propolis administration group (Sham control). As for the teratogenesis rate, propolis was administered, and the teratogenesis rate of the 1.5 Gy radiation exposure group was higher than the 1.5 Gy radiation independent exposure group. But, this is thought anamorphosis appear by propolis administration so long as there was

Application of the personnel photographic monitoring method to determine equivalent radiation dose beyond proton accelerator shielding

International Nuclear Information System (INIS)

Gel'fand, E.K.; Komochkov, M.M.; Man'ko, B.V.; Salatskaya, M.I.; Sychev, B.S.

1980-01-01

Calculations of regularities to form radiation dose beyond proton accelerator shielding are carried out. Numerical data on photographic monitoring dosemeter in radiation fields investigated are obtained. It was shown how to determine the total equivalent dose of radiation fields beyond proton accelerator shielding by means of the photographic monitoring method by introduction into the procedure of considering nuclear emulsions of division of particle tracks into the black and grey ones. A comparison of experimental and calculational data has shown the applicability of the used calculation method for modelling dose radiation characteristics beyond proton accelerator shielding [ru

Determination of beta radiation doses received by personnel involved in the mitigation of the Chernobyl accident

International Nuclear Information System (INIS)

Osanov, D.P.; Krjuchkov, V.P.; Shaks, A.I.

1993-01-01

During the accident at the Chernobyl nuclear power plant on April 26, 1986, and in the post-accident period, workers were exposed to beta and low-energy-photon radiation. This paper describes a method of retrospective estimation of skin doses from these radiations by correlating known doses from gamma radiation. Dose distributions of beta and gamma radiation in tissue-equivalent materials were both calculated and measured using multilayer thermoluminescent dosimeters placed at different site locations. It was determined that the doses to the skin from beta radiation exceeded the maximum doses to the whole-body from gamma radiation by 1 or even 2 orders of magnitude. It is concluded that nuclear power plants should be equipped with multilayer skin dosimeters in order to ensure accurate skin dosimetry. 16 refs., 13 figs., 3 tabs

Estimation of the total effective dose from low-dose CT scans and radiopharmaceutical administrations delivered to patients undergoing SPECT/CT explorations

International Nuclear Information System (INIS)

Montes, C.; Hernandez, J.; Gomez-Caminero, F.; Garcia, S.; Martin, C.; Rosero, A.; Tamayo, P.

2013-01-01

Hybrid imaging, such as single photon emission computed tomography (SPECT)/CT, is used in routine clinical practice, allowing coregistered images of the functional and structural information provided by the two imaging modalities. However, this multimodality imaging may mean that patients are exposed to a higher radiation dose than those receiving SPECT alone. The study aimed to determine the radiation exposure of patients who had undergone SPECT/CT examinations and to relate this to the Background Equivalent Radiation Time (BERT). 145 SPECT/CT studies were used to estimate the total effective dose to patients due to both radiopharmaceutical administrations and low-dose CT scans. The CT contribution was estimated by the Dose-Length Product method. Specific conversion coefficients were calculated for SPECT explorations. The radiation dose from low-dose CTs ranged between 0.6 mSv for head and neck CT and 2.6 mSv for whole body CT scan, representing a maximum of 1 year of background radiation exposure. These values represent a decrease of 80-85% with respect to the radiation dose from diagnostic CT. The radiation exposure from radiopharmaceutical administration varied from 2.1 mSv for stress myocardial perfusion SPECT to 26 mSv for gallium SPECT in patients with lymphoma. The BERT ranged from 1 to 11 years. The contribution of low-dose CT scans to the total radiation dose to patients undergoing SPECT/CT examinations is relatively low compared with the effective dose from radiopharmaceutical administration. When a CT scan is only acquired for anatomical localization and attenuation correction, low-dose CT scan is justified on the basis of its lower dose. (author)

Virtual radiation fields for ALARA determination

Energy Technology Data Exchange (ETDEWEB)

Knight, T.W.

1995-12-31

As computing power has increased, so too has the ability to model and simulate complex systems and processes. In addition, virtual reality technology has made it possible to visualize and understand many complex scientific and engineering problems. For this reason, a virtual dosimetry program called Virtual Radiation Fields (VRF) is developed to model radiation dose rate and cumulative dose to a receptor operating in a virtual radiation environment. With the design and testing of many facilities and products taking place in the virtual world, this program facilitates the concurrent consideration of radiological concerns during the design process. Three-dimensional (3D) graphical presentation of the radiation environment is made possible through the use of IGRIP, a graphical modeling program developed by Deneb Robotics, Inc. The VRF simulation program was designed to model and display a virtual dosimeter. As a demonstration of the program`s capability, the Hanford tank, C-106, was modeled to predict radiation doses to robotic equipment used to remove radioactive waste from the tank. To validate VRF dose predictions, comparison was made with reported values for tank C-106, which showed agreement to within 0.5%. Graphical information is presented regarding the 3D dose rate variation inside the tank. Cumulative dose predictions were made for the cleanup operations of tank C-106. A four-dimensional dose rate map generated by VRF was used to model the dose rate not only in 3D space but also as a function of the amount of waste remaining in the tank. This allowed VRF to predict dose rate at any stage in the waste removal process for an accurate simulation of the radiological conditions throughout the tank cleanup procedure.

Reduction of radiation injury of fresh agricultural products by saccharide

International Nuclear Information System (INIS)

Todoroki, Setsuko; Hayashi, Toru

1999-01-01

Radiation exposure has been paid attention as an alternative technique of methylbromide to protect agricultural products against insects. However, it has been pointed out that radiation at a dose lower than 300-400 Gy necessary for insecticidal effects might produce damages in fresh agricultural products. To reduce such radiation damages, radiation sensitivities of various fresh products were determined to clarify whether sugar treatment is effective for reduction of damages. Further, the timing of the treatment and its influence on the metabolism of agricultural product were investigated. When sucrose was added to a cut flower of chrysanthemum via water before and during irradiation, the withering time of its leaves and flowers was earlier than that of the untreated product, whereas continuous administration of sucrose after radiation exposure caused to lengthen the flower's life and delay the leave's yellowing. Thus, it was indicated that continuous sugar supply after irradiation was effective for prevention of radiation damages. (M.N.)

Adverse Events Involving Radiation Oncology Medical Devices: Comprehensive Analysis of US Food and Drug Administration Data, 1991 to 2015

International Nuclear Information System (INIS)

Connor, Michael J.; Marshall, Deborah C.; Moiseenko, Vitali; Moore, Kevin; Cervino, Laura; Atwood, Todd; Sanghvi, Parag; Mundt, Arno J.; Pawlicki, Todd; Recht, Abram; Hattangadi-Gluth, Jona A.

2017-01-01

Purpose: Radiation oncology relies on rapidly evolving technology and highly complex processes. The US Food and Drug Administration collects reports of adverse events related to medical devices. We sought to characterize all events involving radiation oncology devices (RODs) from the US Food and Drug Administration's postmarket surveillance Manufacturer and User Facility Device Experience (MAUDE) database, comparing these with non–radiation oncology devices. Methods and Materials: MAUDE data on RODs from 1991 to 2015 were sorted into 4 product categories (external beam, brachytherapy, planning systems, and simulation systems) and 5 device problem categories (software, mechanical, electrical, user error, and dose delivery impact). Outcomes included whether the device was evaluated by the manufacturer, adverse event type, remedial action, problem code, device age, and time since 510(k) approval. Descriptive statistics were performed with linear regression of time-series data. Results for RODs were compared with those for other devices by the Pearson χ"2 test for categorical data and 2-sample Kolmogorov-Smirnov test for distributions. Results: There were 4234 ROD and 4,985,698 other device adverse event reports. Adverse event reports increased over time, and events involving RODs peaked in 2011. Most ROD reports involved external beam therapy (50.8%), followed by brachytherapy (24.9%) and treatment planning systems (21.6%). The top problem types were software (30.4%), mechanical (20.9%), and user error (20.4%). RODs differed significantly from other devices in each outcome (P<.001). RODs were more likely to be evaluated by the manufacturer after an event (46.9% vs 33.0%) but less likely to be recalled (10.5% vs 37.9%) (P<.001). Device age and time since 510(k) approval were shorter among RODs (P<.001). Conclusions: Compared with other devices, RODs may experience adverse events sooner after manufacture and market approval. Close postmarket surveillance, improved

Adverse Events Involving Radiation Oncology Medical Devices: Comprehensive Analysis of US Food and Drug Administration Data, 1991 to 2015

Energy Technology Data Exchange (ETDEWEB)

Connor, Michael J. [Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California (United States); Department of Radiation Oncology, University of California Irvine School of Medicine, Irvine, California (United States); Marshall, Deborah C.; Moiseenko, Vitali; Moore, Kevin; Cervino, Laura; Atwood, Todd; Sanghvi, Parag; Mundt, Arno J.; Pawlicki, Todd [Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California (United States); Recht, Abram [Department of Radiation Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts (United States); Hattangadi-Gluth, Jona A., E-mail: jhattangadi@ucsd.edu [Department of Radiation Medicine and Applied Sciences, University of California San Diego, La Jolla, California (United States)

2017-01-01

Purpose: Radiation oncology relies on rapidly evolving technology and highly complex processes. The US Food and Drug Administration collects reports of adverse events related to medical devices. We sought to characterize all events involving radiation oncology devices (RODs) from the US Food and Drug Administration's postmarket surveillance Manufacturer and User Facility Device Experience (MAUDE) database, comparing these with non–radiation oncology devices. Methods and Materials: MAUDE data on RODs from 1991 to 2015 were sorted into 4 product categories (external beam, brachytherapy, planning systems, and simulation systems) and 5 device problem categories (software, mechanical, electrical, user error, and dose delivery impact). Outcomes included whether the device was evaluated by the manufacturer, adverse event type, remedial action, problem code, device age, and time since 510(k) approval. Descriptive statistics were performed with linear regression of time-series data. Results for RODs were compared with those for other devices by the Pearson χ{sup 2} test for categorical data and 2-sample Kolmogorov-Smirnov test for distributions. Results: There were 4234 ROD and 4,985,698 other device adverse event reports. Adverse event reports increased over time, and events involving RODs peaked in 2011. Most ROD reports involved external beam therapy (50.8%), followed by brachytherapy (24.9%) and treatment planning systems (21.6%). The top problem types were software (30.4%), mechanical (20.9%), and user error (20.4%). RODs differed significantly from other devices in each outcome (P<.001). RODs were more likely to be evaluated by the manufacturer after an event (46.9% vs 33.0%) but less likely to be recalled (10.5% vs 37.9%) (P<.001). Device age and time since 510(k) approval were shorter among RODs (P<.001). Conclusions: Compared with other devices, RODs may experience adverse events sooner after manufacture and market approval. Close postmarket surveillance

Absolute determination of radiation bursts and of proportional counters space charge effect through the influence method

International Nuclear Information System (INIS)

Rios, I.J.; Mayer, R.E.

2016-01-01

When proportional counters are employed in charge integration mode to determine the magnitude of a radiation pulse, so intense that individual detection events take place in a time too short to produce individual output pulses, mostly in pulsed neutron sources, the strong build-up of positive space charge reduces the electric multiplication factor of the proportional detector. Under such conditions the ensuing measurement underestimates the amount of radiation that interacted with the detector. If the geometric characteristics, the filling gas pressure and the voltage applied to that detector are known, it becomes possible to apply an analytical correction method to the measurement. In this article we present a method that allows to determine the absolute value of the detected radiation burst without the need to know the characteristics of the employed detectors. It is necessary to employ more than one detector, taking advantage of the Influence Method. The “Influence Method” is conceived for the absolute determination of a nuclear particle flux in the absence of known detector efficiency and without the need to register coincidences of any kind. This method exploits the influence of the presence of one detector in the count rate of another detector, when they are placed one behind the other and define statistical estimators for the absolute number of incident particles and for the efficiency (Rios and Mayer, 2015 [1,2]). Its practical implementation in the measurement of a moderated neutron flux arising from an isotopic neutron source was exemplified in (Rios and Mayer, 2016 [3]) and the extension for multiple detectors in (Rios and Mayer 2016 [4]). - Highlights: • Absolute determination of radiation burst. • Proportional counters space charge effect. • Radiation measurements on pulsed devices.

Size determination of an equilibrium enzymic system by radiation inactivation

International Nuclear Information System (INIS)

Simon, P.; Swillens, S.; Dumont, J.E.

1982-01-01

Radiation inactivation of complex enzymic systems is currently used to determine the enzyme size and the molecular organization of the components in the system. An equilibrium model was simulated describing the regulation of enzyme activity by association of the enzyme with a regulatory unit. It is assumed that, after irradiation, the system equilibrates before the enzyme activity is assayed. The theoretical results show that the target-size analysis of these numerical data leads to a bad estimate of the enzyme size. Moreover, some implicit assumptions such as the transfer of radiation energy between non-covalently bound molecules should be verified before interpretation of target-size analysis. It is demonstrated that the apparent target size depends on the parameters of the system, namely the size and the concentration of the components, the equilibrium constant, the relative activities of free enzyme and enzymic complex, the existence of energy transfer, and the distribution of the components between free and bound forms during the irradiation. (author)

Radiation analysis devices, radiation analysis methods, and articles of manufacture

Science.gov (United States)

Roybal, Lyle Gene

2010-06-08

Radiation analysis devices include circuitry configured to determine respective radiation count data for a plurality of sections of an area of interest and combine the radiation count data of individual of sections to determine whether a selected radioactive material is present in the area of interest. An amount of the radiation count data for an individual section is insufficient to determine whether the selected radioactive material is present in the individual section. An article of manufacture includes media comprising programming configured to cause processing circuitry to perform processing comprising determining one or more correction factors based on a calibration of a radiation analysis device, measuring radiation received by the radiation analysis device using the one or more correction factors, and presenting information relating to an amount of radiation measured by the radiation analysis device having one of a plurality of specified radiation energy levels of a range of interest.

Accelerated regression of brain metastases in patients receiving whole brain radiation and the topoisomerase II inhibitor, lucanthone

International Nuclear Information System (INIS)

Rowe, John D. del; Bello, Jacqueline; Mitnick, Robin; Sood, Brij; Filippi, Christopher; Moran, Justin Ph.D.; Freeman, Katherine; Mendez, Frances; Bases, Robert

1999-01-01

Purpose: To determine if lucanthone crossed the blood-brain barrier in experimental animals; and to determine accelerated tumor regression of human brain metastases treated jointly with lucanthone and whole brain radiation. Methods and Materials: The organ distribution of 3 H lucanthone in mice and 125 I lucanthone in rats was determined to learn if lucanthone crossed the blood-brain barrier. Size determinations were made of patients' brain metastases from magnetic resonance images or by computed tomography before and after treatment with 30 Gy whole brain radiation alone or with lucanthone. Results: The time course of lucanthone's distribution in brain was identical to that in muscle and heart after intraperitoneal or intravenous administration in experimental animals. Lucanthone, therefore, readily crossed the blood-brain barrier in experimental animals. Conclusion: Compared with radiation alone, the tumor regression in patients with brain metastases treated with lucanthone and radiation was accelerated, approaching significance using a permutation test at p = 0.0536

Field dose radiation determination by active learning with Gaussian Process for autonomous robot guiding

International Nuclear Information System (INIS)

Freitas Naiff, Danilo de; Silveira, Paulo R.; Pereira, Claudio M.N.A.

2017-01-01

This article proposes an approach for determination of radiation dose pro le in a radiation-susceptible environment, aiming to guide an autonomous robot in acting on those environments, reducing the human exposure to dangerous amount of dose. The approach consists of an active learning method based on information entropy reduction, using log-normally warped Gaussian Process (GP) as surrogate model, resulting in non-linear online regression with sequential measurements. Experiments with simulated radiation dose fields of varying complexity were made, and results showed that the approach was effective in reconstruct the eld with high accuracy, through relatively few measurements. The technique was also shown some robustness in presence measurement noise, present in real measurements, by assuming Gaussian noise. (author)

Field dose radiation determination by active learning with Gaussian Process for autonomous robot guiding

Energy Technology Data Exchange (ETDEWEB)

Freitas Naiff, Danilo de; Silveira, Paulo R.; Pereira, Claudio M.N.A., E-mail: danilonai1992@poli.ufrj.br, E-mail: paulo@lmp.ufrj.br, E-mail: cmnap@ien.gov.br [Coordenacao de Pos-Graduacao e Pesquisa de Engenharia (PEN/COPPE/UFRJ), Rio de Janeiro, RJ (Brazil); Instituto de Engenharia Nuclear (IEN/CNEN-RJ), Rio de Janeiro, RJ (Brazil)

2017-11-01

This article proposes an approach for determination of radiation dose pro le in a radiation-susceptible environment, aiming to guide an autonomous robot in acting on those environments, reducing the human exposure to dangerous amount of dose. The approach consists of an active learning method based on information entropy reduction, using log-normally warped Gaussian Process (GP) as surrogate model, resulting in non-linear online regression with sequential measurements. Experiments with simulated radiation dose fields of varying complexity were made, and results showed that the approach was effective in reconstruct the eld with high accuracy, through relatively few measurements. The technique was also shown some robustness in presence measurement noise, present in real measurements, by assuming Gaussian noise. (author)

Simple method of determining induced 32P activity following burning of sulfur tablets by measuring Cherenkov radiation

International Nuclear Information System (INIS)

Kubicek, I.

1986-01-01

A method is described allowing the detemination of induced beta activity of phosphorus-32 using Cherenkov radiation, following the burning of sulfur tablets in the measuring vesels. A mixture of phosphoric acid and sodium phosphate solutions was used as the medium for the production of Cherenkov radiation. The losses of activity during sulfur tablet burning, the detection efficiency and the minimum detectable activity for which the minimum determinable dose was estimated, were determined. The results obtained by measurement with Cherenkov radiation are compared with other techniques of phosphorus-32 detection. The method was tested at VUPL Bratislava on detectors irradited using a 252 Cf fast neutron source. From Caswell's data, the fluence-to-kerma conversin factor was determined for a neutron spectrum calculated by the Monte Carlo method. Tissue kerma was estimated from the neutron fluence corresponding to the appropriate values of saturated activity per 1 sulfur-32 nucleus. (author)

Determination of the LEP Beam Energy using Radiative Fermion-pair Events, 2004

CERN Document Server

Abbiendi, G; Åkesson, P F; Alexander, G; Allison, J; Amaral, P; Anagnostou, G; Anderson, K J; Asai, S; Axen, D A; Bailey, I; Barberio, E; Barillari, T; Barlow, R J; Batley, J Richard; Bechtle, P; Behnke, T; Bell, K W; Bell, P J; Bella, G; Bellerive, A; Benelli, G; Bethke, Siegfried; Biebel, O; Boeriu, O; Bock, P; Boutemeur, M; Braibant, S; Brown, R M; Burckhart, H J; Campana, S; Capiluppi, P; Carnegie, R K; Carter, A A; Carter, J R; Chang, C Y; Charlton, D G; Ciocca, C; Csilling, A; Cuffiani, M; Dado, S; de Roeck, A; De Wolf, E A; Desch, Klaus; Dienes, B; Donkers, M; Dubbert, J; Duchovni, E; Duckeck, G; Duerdoth, I P; Etzion, E; Fabbri, Franco Luigi; Ferrari, P; Fiedler, F; Fleck, I; Ford, M; Frey, A; Gagnon, P; Gary, J W; Geich-Gimbel, C; Giacomelli, G; Giacomelli, P; Giunta, M; Goldberg, J; Gross, E; Grunhaus, Jacob; Gruwé, M; Günther, P O; Sen-Gupta, A; Hajdu, C; Hamann, M; Hanson, G G; Harel, A; Hauschild, M; Hawkes, C M; Hawkings, R; Hemingway, R J; Herten, G; Heuer, R D; Hill, J C; Hoffman, K; Horváth, D; Igo-Kemenes, P; Ishii, K; Jeremie, H; Jovanovic, P; Junk, T R; Kanzaki, J; Karlen, Dean A; Kawagoe, K; Kawamoto, T; Keeler, R K; Kellogg, R G; Kennedy, B W; Kluth, S; Kobayashi, T; Kobel, M; Komamiya, S; Kramer, T; Krieger, P; Von Krogh, J; Kühl, T; Kupper, M; Lafferty, G D; Landsman, Hagar Yaël; Lanske, D; Lellouch, D; Letts, J; Levinson, L; Lillich, J; Lloyd, S L; Loebinger, F K; Lü, J; Ludwig, A; Ludwig, J; Mader, W; Marcellini, S; Martin, A J; Masetti, G; Mashimo, T; Mättig, P; McKenna, J A; McPherson, R A; Meijers, F; Menges, W; Merritt, F S; Mes, H; Meyer, N; Michelini, A; Mihara, S; Mikenberg, G; Miller, D J; Mohr, W; Mori, T; Mutter, A; Nagai, K; Nakamura, I; Nanjo, H; Neal, H A; Nisius, R; O'Neale, S W; Oh, A; Oreglia, M J; Orito, S; Pahl, C; Pásztor, G; Pater, J R; Pilcher, J E; Pinfold, J L; Plane, D E; Pooth, O; Przybycien, M B; Quadt, A; Rabbertz, K; Rembser, C; Renkel, P; Roney, J M; Rossi, A M; Rozen, Y; Runge, K; Sachs, K; Saeki, T; Sarkisyan-Grinbaum, E; Schaile, A D; Schaile, O; Scharff-Hansen, P; Schieck, J; Schörner-Sadenius, T; Schröder, M; Schumacher, M; Seuster, R; Shears, T G; Shen, B C; Sherwood, P; Skuja, A; Smith, A M; Sobie, R J; Söldner-Rembold, S; Spanó, F; Stahl, A; Strom, D; Ströhmer, R; Tarem, S; Tasevsky, M; Teuscher, R; Thomson, M A; Torrence, E; Toya, D; Tran, P; Trigger, I; Trócsányi, Z L; Tsur, E; Turner-Watson, M F; Ueda, I; Ujvári, B; Vollmer, C F; Vannerem, P; Vertesi, R; Verzocchi, M; Voss, H; Vossebeld, Joost Herman; Ward, C P; Ward, D R; Watkins, P M; Watson, A T; Watson, N K; Wells, P S; Wengler, T; Wermes, N; Wilson, G W; Wilson, J A; Wolf, G; Wyatt, T R; Yamashita, S; Zer-Zion, D; Zivkovic, L

2004-01-01

We present a determination of the LEP beam energy using "radiative return" fermion-pair events recorded at centre-of-mass energies from 183 GeV to 209 GeV. We find no evidence of a disagreement between the OPAL data and the LEP Energy Workings Group's standard calibration. Including the energy- averaged 11 MeV uncertainty in the standard determination, the beam energy we obtain from the OPAL data is higher than that obtained from the LEP calibration by 0+-34(stat.)+-27(syst.)MeV

Determination of dose rates in beta radiation fields using extrapolation chamber and GM counter

International Nuclear Information System (INIS)

Borg, J.; Christensen, P.

1995-01-01

The extrapolation chamber measurement method is the basic method for the determination of dose rates in beta radiation fields and the method has been used for the establishment of beta calibration fields. The paper describes important details of the method and presents results from the measurements of depth-dose profiles from different beta radiation fields with E max values down to 156 keV. Results are also presented from studies of GM counters for use as survey instruments for monitoring beta dose rates at the workplace. Advantages of GM counters are a simple measurement technique and high sensitivity. GM responses were measured from exposures in different beta radiation fields using different filters in front of the GM detector and the paper discusses the possibility of using the results from GM measurements with two different filters in an unknown beta radiation field to obtain a value of the dose rate. (Author)

Determining the radiative properties of pulverized-coal particles from experiments. Final report

Energy Technology Data Exchange (ETDEWEB)

Menguec, M.P.

1992-02-01

A comprehensive coupled experimental-theoretical study has been performed to determine the effective radiative properties of pulverized-coal/char particles. The results obtained show that the ``effective`` scattering phase function of coal particles are highly forward scattering and show less sensitivity to the size than predicted from the Lorenz-Mie theory. The main reason for this is the presence of smaller size particles associated with each larger particle. Also, the coal/char particle clouds display more side scattering than predicted for the same size range spheres, indicating the irregular shape of the particles and fragmentation. In addition to these, it was observed that in the visible wavelength range the coal absorption is not gray, and slightly vary with the wavelength. These two experimental approaches followed in this study are unique in a sense that the physics of the problem are not approximated. The properties determined include all uncertainties related to the particle shape, size distribution, inhomogeneity and spectral complex index of refraction data. In order to obtain radiative property data over a wider wavelength spectrum, additional ex-situ experiments have been carried out using a Fourier Transform Infrared (FT-IR) Spectrometer. The spectral measurements were performed over the wavelength range of 2 to 22 {mu}m. These results were interpreted to obtain the ``effective`` efficiency factors of coal particles and the corresponding refractive index values. The results clearly show that the coal/char radiative properties display significant wavelength dependency in the infrared spectrum.

Determination of the minimal phototoxic dose and colorimetry in psoralen plus ultraviolet A radiation therapy.

Science.gov (United States)

Kraemer, Cristine Kloeckner; Menegon, Dóris Baratz; Cestari, Tania Ferreira

2005-10-01

The use of an adequate initial dose of ultraviolet A (UVA) radiation for photochemotherapy is important to prevent burns secondary to overdosage, meanwhile avoiding a reduced clinical improvement and long-term risks secondary to underdosage. The ideal initial dose of UVA can be achieved based on the phototype and the minimal phototoxic dose (MPD). The objective measurement of constitutive skin color (colorimetry) is another method commonly used to quantify the erythematous skin reaction to ultraviolet radiation exposure. The aim of this study was to determine variations in MPD and constitutional skin color (coordinate L(*)) within different phototypes in order to establish the best initial dose of UVA radiation for photochemotherapy patients. Thirty-six patients with dermatological conditions and 13 healthy volunteers were divided into five groups according to phototype. Constitutional skin color of the infra-axillary area was assessed by colorimetry. The infra-axillary area was subsequently divided into twelve 1.5 cm(2) regions to determine the MPD; readings were performed 72 h after oral administration of 8-methoxypsoralen (MOP) followed by exposure of the demarcated regions to increasing doses of UVA. The majority of the participants were women (73.5%) and their mean age was 38.8 years. The MPD ranged from 4 to 12 J/cm(2) in phototypes II and III; from 10 to 18 J/cm(2) in type IV; from 12 to 24 J/cm(2) in type V and from 18 to 32 J/cm(2) in type VI. The analysis of colorimetric values (L(*) coordinate) and MPD values allowed the definition of three distinctive groups of individuals composed by phototypes II and III (group 1), types IV and V (group 2), and phototype VI (group 3). MPD and L(*) coordinate showed variation within the same phototype and superposition between adjacent phototypes. The values of the L(*) coordinate and the MPD lead to the definition of three distinct sensitivity groups: phototypes II and III, IV and V and type VI. Also, the MPD values

78 FR 59949 - Annual Factors for Determining Public Housing Agency Administrative Fees for the Section 8...

Science.gov (United States)

2013-09-30

... DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT [Docket No. FR-5724-N-02] Annual Factors for... Web site of the annual factors for determining the on-going administrative fee for housing agencies... Relay Service during business hours at 1-800-877-8337. SUPPLEMENTARY INFORMATION: The annual factors for...

Contemporary Development Trends in Administrative-Legal Relations in the System of Administrative Justice

Science.gov (United States)

Abdikerimova, Aynur A.

2016-01-01

The purpose of the study is to determine the main contemporary development trends in administrative-legal relations in the field of administrative justice. In order to examine theoretical and practical issues of modern administrative justice, normative legal acts identifying the relations in the system of administrative justice in the Republic in…

Radiation surveillance procedure during veterinary application of radioisotope

International Nuclear Information System (INIS)

Kamaldeep; Bhaktivinayagam, A.; Singh, Sanjay Kumar

2012-01-01

Radioisotopes have found wide applications in the field of biomedical veterinary nuclear medicine and research. Radiation safety issues during internal administration of radioisotopes to laboratory animals, unlike human use, are far more challenging and requires stringent, well planned and an organized system of radiation protection in the animal house facility. In this paper, we discuss our experience during veterinary research experiments involving use, handling and administration of liquid sources of 131 I. With extensive radiation protection surveillance and application of practical and essential radiation safety and hygiene practices, the radiation exposure and contamination levels during the veterinary application of isotopes can be kept ALARA

Pre-administration of safe exogenous substance minimizes radiation induced bone-marrow aplsia which may otherwise lead to hematopoietic disaster

International Nuclear Information System (INIS)

Gupta, Manju Lata; Verma, Savita; Ranjan, Rajiv

2014-01-01

Radiation induces injuries to biological system primarily by producing free radicals and also by directly interacting with cellular entities. In irradiated animals hematopoietic system gets severely affected leading to inactive microenvironment, damaged blood vessels and non functional endothelial cells of the marrow. Vascular damage inhibits the efficacy of stem cells to proliferate and differentiate. Release of pro-inflammatory cytokines and activation of fibroblast further contribute to the development of radiation-induced fibrosis. Various findings have revealed the occurrence of radiation induced aplasia and vascular damage cause large number of RBCs occupying the space and intrusion of fibrotic cells in the marrow of irradiated mice. Administration of effective radioprotective agents prior to irradiation has been amply reported for significant decline in the grade of vascular damage and inclusion of marrow fibrous tissues in these animals. In addition the formulations have also shown the presence stem cell population which is efficient to proliferate, differentiate and ultimately enrich bone marrow cellularity within 25-40 days depending on type of radiation and its dose and dose rate. Protection to bone marrow is multi-factorial phenomenon out of which inhibition of radiation induced free radical generation has been recognized as the key factor but essentially not the lone one. Protection to colony forming ability of bone marrow is also critically important which occurs mainly due to DNA protection and up-regulation of repair pathways. Preservation of microenvironment for providing stem cells to remain functional is lately reported as equally prominent factor. Our studies on a combination of two compounds of natural origin, administered to lethally irradiated animals have shown recovery in stem/precursor cells of all hematopoietic lineages. Major entities related to hematopoietic system were found nearly 90% recovered within 30 days. Current talk is focused

Radiation Alert Immediate Disclosure, Phase II

Data.gov (United States)

National Aeronautics and Space Administration — Invocon's Radiation Alert Immediate Disclosure (RAID) system is a miniature, low-power, real-time, active radiation badge. It is designed for monitoring personnel,...

External carotid artery flow maintains near infrared spectroscopy-determined frontal lobe oxygenation during ephedrine administration

DEFF Research Database (Denmark)

Sørensen, H; Rasmussen, P; Sato, K

2014-01-01

O₂ by 10.5 (8.2-12.9%; Padministration of ephedrine while SinvosO₂ and SavO₂ decreased [by 3.1 (0.7-4.5%; P=0.017) and 2.1 (0.5-3.3%; P=0.......012)] as arterial carbon dioxide pressure decreased (P=0.003). ICAf was stable and ECAf increased by 11 (4-18%; P=0.005) with administration of ephedrine while SskinO₂ did not change. CONCLUSIONS: The effect of phenylephrine on ScO₂ is governed by a decrease in external carotid blood flow since it increases...... cerebral blood flow as determined by flow in the internal carotid artery. In contrast, ScO₂ is largely maintained with administration of ephedrine because blood flow to extracerebral tissue increases....

Determination of Carbamate and Organophosphorus Pesticides in Vegetable Samples and the Efficiency of Gamma-Radiation in Their Removal

Directory of Open Access Journals (Sweden)

Muhammed Alamgir Zaman Chowdhury

2014-01-01

Full Text Available In the present study, the residual pesticide levels were determined in eggplants (Solanum melongena (n=16, purchased from four different markets in Dhaka, Bangladesh. The carbamate and organophosphorus pesticide residual levels were determined by high performance liquid chromatography (HPLC, and the efficiency of gamma radiation on pesticide removal in three different types of vegetables was also studied. Many (50% of the samples contained pesticides, and three samples had residual levels above the maximum residue levels determined by the World Health Organisation. Three carbamates (carbaryl, carbofuran, and pirimicarb and six organophosphates (phenthoate, diazinon, parathion, dimethoate, phosphamidon, and pirimiphos-methyl were detected in eggplant samples; the highest carbofuran level detected was 1.86 mg/kg, while phenthoate was detected at 0.311 mg/kg. Gamma radiation decreased pesticide levels proportionately with increasing radiation doses. Diazinon, chlorpyrifos, and phosphamidon were reduced by 40–48%, 35–43%, and 30–45%, respectively, when a radiation strength of 0.5 kGy was utilized. However, when the radiation dose was increased to 1.0 kGy, the levels of the pesticides were reduced to 85–90%, 80–91%, and 90–95%, respectively. In summary, our study revealed that pesticide residues are present at high amounts in vegetable samples and that gamma radiation at 1.0 kGy can remove 80–95% of some pesticides.

14 CFR 23.1023 - Oil radiators.

Science.gov (United States)

2010-01-01

... 14 Aeronautics and Space 1 2010-01-01 2010-01-01 false Oil radiators. 23.1023 Section 23.1023 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS... radiators. Each oil radiator and its supporting structures must be able to withstand the vibration, inertia...

D-xylose test of resorption as a method to determine radiation side effects in small intestine

International Nuclear Information System (INIS)

Koest, S.; Keinert, K.; Glaser, F.H.

1998-01-01

Background: The D-xylose test is the most important method to determine a disorder of carbohydrates resorption in proximal small intestine. The application is based on an impaired resorption due to pathological change of small intestine surface, leading to a decreased blood level or decreased excretion in urine. Patients and Method: D-xylose test was applied in 91 patients before, shortly after, 1/2 and 1 year after radiotherapy. All patients received an abdominal radiotherapy. We determined the blood level of D-xylose by a capillary blood sample 1 hour after oral D-xylose administration. Results: A significant decrease of the mean blood level of D-xylose to 1.88 mmol/l was determined after radiotherapy in comparison with 2.17 mmol/l before radiotherapy. Half a year after radiotherapy the mean blood level of D-xylose returned to normal. Regarding a threshold value of D-xylose blood level of 1.70 mmol/l 29 patients (32%) showed a pathologically decreased D-xylose resorption after radiotherapy. Twenty out of the 29 patients already showed a normal resorption half a year after the determination of the resorption disorder, 5 patients after 1 year and 4 patients after 1 1/2 years. There was no correlation between the detection of a disorder of D-xylose resorption and of a loss of body weight. The acute clinical side effects seemed to be more marked in connection with a disorder of D-xylose resorption, but this correlation is not significant. Eleven or 14 of the 29 patients, respectively, with pathologically decreased D-xylose resorption only had complaints of lower or upper gastrointestinal tract, respectively, and 10 patients did not have abdominal complaints at all. Conclusions: The D-xylose test is an important and simple method for determination of radiogen induced carbohydrate malabsorption in proximal small intestine. By means of its radiation side effects on small intestine can also be determined in patients who are otherwise free of complaints. (orig.) [de

Method for determining correction factors induced by irradiation of ionization chamber cables in large radiation field

International Nuclear Information System (INIS)

Rodrigues, L.L.C.

1988-01-01

A simple method was developed to be suggested to hospital physicists in order to be followed during large radiation field dosimetry, to evaluate the effects of cables, connectors and extension cables irradiation and to determine correction factors for each system or geometry. All quality control tests were performed according to the International Electrotechnical Commission for three clinical dosimeters. Photon and electron irradiation effects for cables, connectors and extention cables were investigated under different experimental conditions by means of measurements of chamber sensitivity to a standard radiation source of 90 Sr. The radiation induced leakage current was also measured for cables, connectors and extension cables irradiated by photons and electrons. All measurements were performed at standard dosimetry conditions. Finally, measurements were performed in large fields. Cable factors and leakage factors were determined by the relation between chamber responses for irradiated and unirradiated cables. (author) [pt

Radiative transfer modeling applied to sea water constituent determination. [Gulf of Mexico

Science.gov (United States)

Faller, K. H.

1979-01-01

Optical radiation from the sea is influenced by pigments dissolved in the water and contained in discrete organisms suspended in the sea, and by pigmented and unpigmented inorganic and organic particles. The problem of extracting the information concerning these pigments and particulates from the optical properties of the sea is addressed and the properties which determine characteristics of the radiation that a remote sensor will detect and measure are considered. The results of the application of the volume scattering function model to the data collected in the Gulf of Mexico and its environs indicate that the size distribution of the concentrations of particles found in the sea can be predicted from measurements of the volume scattering function. Furthermore, with the volume scattering function model and knowledge of the absorption spectra of dissolved pigments, the radiative transfer model can compute a distribution of particle sizes and indices of refraction and concentration of dissolved pigments that give an upwelling light spectrum that closely matches measurements of that spectrum at sea.

Determination of the permeability of α-, β- and γ-radiation in textile fabrics by Gamma-Scout device

International Nuclear Information System (INIS)

Gintibidze, N.; Mardaleishvili, Z.

2009-01-01

The goal of the present was the measurement of radiation permeability in textile fabrics by Gamma-Scout device and the comparison of the obtained results with the radiation background of the ambient air. The authors of this article have produced new fiber Fibron-3, which, according to theoretical calculations, reduces permeability of solar radiation. With this in mind, an experiment was performed. Three samples of the knitted cloth from Fibron-3 were taken, and the permeability of solar radiation in them was determined. The measurements were performed on Gamma-Scout device. The comparative analysis of the permeability of solar radiation in fabrics of different fibrous structure was performed. It was inferred that the degree of radiation permeability in fabrics depended on the thread thickness and the fiber structure. (author)

Meeting the challenge of managed care - Part III: Information systems for radiation oncology practice

International Nuclear Information System (INIS)

Kijewski, Peter

1997-01-01

Purpose: This course will review topics to be considered when defining an information systems plan for a department of radiation oncology. A survey of available systems will be presented. Computer information systems can play an important role in the effective administration and operation of a department of radiation oncology. Tasks such as 1) scheduling for physicians, patients, and rooms, 2) charge collection and billing, 3) administrative reporting, and 4) treatment verification can be carried out efficiently with the assistance of computer systems. Operating a department without a state of art computer system will become increasingly difficult as hospitals and healthcare buyers increasingly rely on computer information technology. Communication of the radiation oncology system with outside systems will thus further enhance the utility of the computer system. The steps for the selection and installation of an information system will be discussed: 1) defining the objectives, 2) selecting a suitable system, 3) determining costs, 4) setting up maintenance contracts, and 5) planning for future upgrades

Determination of gamma radiation dose for destruction of Salmonella spp. in chicken flesh

International Nuclear Information System (INIS)

Santos, Andreia Ferreira dos

1997-01-01

The aim of this study was to determinate: 1) the radio sensibility of Salmonella typhimurium ATCC 14028 in soy trypticase broth; 2) the radio sensibility of Salmonella typhimurium ATCC 14028 in chicken thigh and; 3) to recommend a radiation dose which can be non hazardous for human consumption

7 CFR 800.2 - Administrator.

Science.gov (United States)

2010-01-01

... which would not impair the objectives of the Act, suspend for period determined by the Administrator any... ADMINISTRATION (FEDERAL GRAIN INSPECTION SERVICE), DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS Administration... administration of the United States Grain Standards Act and responsibilities under the Agricultural Marketing Act...

Cost effective radiation risk management in a generic nuclear plant design

International Nuclear Information System (INIS)

Maan, M.A.

1982-11-01

To determine whether any further dose reduction measures are justified, a method appropriate for cost effective radiation risk management has been developed. This new method is based on the radiation detriment optimization measures advocated in the revised (1977) ALARA concept. The methodology includes the determination of available alternatives, and the determination of the variable monetary ceiling on expenditures to reduce the radiological detriment (both occupational and public). The method used to determine the maximum justifiable expenditure for additional reduction of detriment takes into account the economic and social climate, administrative/legal exposure limits, and the actual magnitude of risk. All these factors may vary from country to country. The variable monetary ceiling, sensitive to an actual level of risk, provides a handy measure allowing designers to make a decision whether or not the modification of design is necessary and/or cost effective. This will ensure rationally and consistently that the utilities and their customers (public) get maximum benefit for their safety dollars

Transcriptional Response in Mouse Thyroid Tissue after 211At Administration: Effects of Absorbed Dose, Initial Dose-Rate and Time after Administration.

Directory of Open Access Journals (Sweden)

Nils Rudqvist

Full Text Available 211At-labeled radiopharmaceuticals are potentially useful for tumor therapy. However, a limitation has been the preferential accumulation of released 211At in the thyroid gland, which is a critical organ for such therapy. The aim of this study was to determine the effect of absorbed dose, dose-rate, and time after 211At exposure on genome-wide transcriptional expression in mouse thyroid gland.BALB/c mice were i.v. injected with 1.7, 7.5 or 100 kBq 211At. Animals injected with 1.7 kBq were killed after 1, 6, or 168 h with mean thyroid absorbed doses of 0.023, 0.32, and 1.8 Gy, respectively. Animals injected with 7.5 and 100 kBq were killed after 6 and 1 h, respectively; mean thyroid absorbed dose was 1.4 Gy. Total RNA was extracted from pooled thyroids and the Illumina RNA microarray platform was used to determine mRNA levels. Differentially expressed transcripts and enriched GO terms were determined with adjusted p-value 1.5, and p-value <0.05, respectively.In total, 1232 differentially expressed transcripts were detected after 211At administration, demonstrating a profound effect on gene regulation. The number of regulated transcripts increased with higher initial dose-rate/absorbed dose at 1 or 6 h. However, the number of regulated transcripts decreased with mean absorbed dose/time after 1.7 kBq 211At administration. Furthermore, similar regulation profiles were seen for groups administered 1.7 kBq. Interestingly, few previously proposed radiation responsive genes were detected in the present study. Regulation of immunological processes were prevalent at 1, 6, and 168 h after 1.7 kBq administration (0.023, 0.32, 1.8 Gy.

PHYTOTHERAPEUTIC EFFECT OF AVOCADOS AND SOYA AS DRUG ON HEART OF RATS EXPOSED TO GAMMA RADIATION

International Nuclear Information System (INIS)

OMRAN, M.F.; IBRAHIM, N.K.; ABU-ZIED, N.M.

2008-01-01

This study was planed to determine the role of single oral dose of avocados and soya in irradiated rats exposed to gamma radiation. the experimental animals were randomly divided into four groups; 12 rats for each. Group 1: kept as control. Group 2: rats received piascledine for 14 consecutive days. Group 3: rats submitted to whole body gamma rays (4 Gy). Group 4: rats received the same piascledine 14 days post-exposure to 4 Gy gamma radiation. The animals were weighed then dissected after one and fourteen days post-administration and the cardiac tissue and plasma were stored at 12 oC till used for biochemical analysis and kept in ice. The following parameters were determined: plasma total cholesterol, triacylglycerol, high density lipoprotein-cholesterol, low density lipoprotein-cholesterol, LDH, phospholipids, ALT, CPK and TBARS. In cardiac tissue, determinations of total cholesterol, triacylglycerol, phospholipids and TBARS were conducted.It can be concluded that administration of avocados and soy as natural drug (piascledine) post-irradiation in rats is a favorable modificator against the impaired physiological processes in animal body due to gamma irradiation

GLERL Radiation Transfer Through Freshwater Ice

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Radiation transmittance (ratio of transmitted to incident radiation) through clear ice, refrozen slush ice and brash ice, from ice surface to ice-water interface in...

Real time determination of dose radiation through artificial intelligence and virtual reality

International Nuclear Information System (INIS)

Freitas, Victor G.G.; Mol, Antonio C.A.; Pereira, Claudio M.N.A.

2009-01-01

In the last years, a virtual environment of Argonauta research reactor, sited in the Instituto de Engenharia Nuclear (Brazil), has been developed. Such environment, called here Argonauta Virtual (AV), is a 3D model of the reactor hall, in which virtual people (avatar) can navigate. In AV, simulations of nuclear sources and doses are possible. In a recent work, a real time monitoring system (RTMS) was developed to provide (by means of Ethernet TCP/IP) the information of area detectors situated in the reactor hall. Extending the scope of AV, this work is intended to provide a continuous determination of gamma radiation dose in the reactor hall, based in several monitored parameters. To accomplish that a module based in artificial neural network (ANN) was developed. The ANN module is able to predict gamma radiation doses using as inputs: the avatar position (from virtual environment), the reactor power (from RTMS) and information of fixed area detectors (from RTMS). The ANN training data has been obtained by measurements of gamma radiation doses in a mesh of points, with previously defined positions, for different power levels. Through the use of ANN it is possible to estimate, in real time, the dose received by a person at any position in Argonauta reactor hall. Such approach allows tasks simulations and training of people inside the AV system, without exposing them to radiation effects. (author)

Real time determination of dose radiation through artificial intelligence and virtual reality

International Nuclear Information System (INIS)

Freitas, Victor Goncalves Gloria

2009-01-01

In the last years, a virtual environment of Argonauta research reactor, sited in the Instituto de Engenharia Nuclear (Brazil), has been developed. Such environment, called here Argonauta Virtual (AV), is a 3D model of the reactor hall, in which virtual people (avatar) can navigate. In AV, simulations of nuclear sources and doses are possible. In a recent work, a real time monitoring system (RTMS) was developed to provide (by means of Ethernet TCP/I P) the information of area detectors situated in the reactor hall. Extending the scope of AV, this work is intended to provide a continuous determination of gamma radiation dose in the reactor hall, based in several monitored parameters. To accomplish that a module based in artificial neural network (ANN) was developed. The ANN module is able to predict gamma radiation doses using as inputs: the avatar position (from virtual environment), the reactor power (from RTMS) and information of fixed area detectors (from RTMS). The ANN training data has been obtained by measurements of gamma radiation doses in a mesh of points, with previously defined positions, for different power levels. Through the use of ANN it is possible to estimate, in real time, the dose received by a person at any position in Argonauta reactor hall. Such approach allows tasks simulations and training of people inside the AV system, without exposing them to radiation effects. (author)

Radiation protection guidelines for space missions

International Nuclear Information System (INIS)

Fry, R.J.; Nachtwey, D.S.

1988-01-01

The current radiation protection guidelines of the National Aeronautics and Space Administration (NASA) were recommended in 1970. The career limit was set at 4.0 Sv (400 rem). Using the same approach as in 1970 but current risk estimates, a considerably lower career limit would obtain today. Also, there is now much more information about the radiation environments that will be experienced in different missions. Furthermore, since 1970 women have joined the ranks of the astronauts. For these and other reasons, it was considered necessary to re-examine the radiation protection guidelines. This task has been undertaken by the National Council on Radiation Protection and Measurements Scientific Committee 75. Within the magnetosphere, the radiation environment varies with altitude and inclination of the orbit. In outer space missions, galactic cosmic rays, with the small but important heavy-ion component, determine the radiation environment. The new recommendations for career dose limits, based on lifetime excess risk of cancer mortality, take into account age at first exposure and sex. The career limits range from 1.0 Sv (100 rem) for a 24-y-old female up to 4.0 Sv (400 rem) for a 55-y-old male, compared with the previous single limit of 4.0 Sv (400 rem). The career limit for the lens of the eye has been reduced from 6.0 Sv (600 rem) to 4.0 Sv (400 rem)

Fetal absorbed doses by radiopharmaceutical administration

International Nuclear Information System (INIS)

Rojo, Ana M; Gomez Parada, Ines M.; Di Trano, Jose L.

2000-01-01

The radiopharmaceutical administration with diagnostic or therapeutic purpose during pregnancy implies a prenatal radiation dose. The dose assessment and the evaluation of the radiological risks become relevant due to the great radiosensitivity of the fetal tissues in development. This paper is a revision of the available data for estimating fetal doses in the cases of the more frequently used radiopharmaceuticals in nuclear medicine, taking into account recent investigation in placental crossover. The more frequent diagnostic and therapeutic procedures were analyzed according to the radiation doses implied. (author)

Phosphorus-32: practical radiation protection

International Nuclear Information System (INIS)

Ballance, P.E.; Morgan, J.

1987-01-01

This monograph offers practical advice to Radiation Protection Advisors, Radiation Protection Supervisors and Research Supervisors, together with research workers, particularly those in the field of molecular biological research. The subject is dealt with under the following headings: physical properties, radiation and measurement methods, radiation units, phosphorus metabolism and health risks, protection standards and practical radiation protection, administrative arrangements, accidents, decontamination, emergency procedures, a basic written system for radiochemical work, with specialised recommendations for 32 P, and guidance notes of accident situations involving 32 P. (U.K.)

Radiation Protection and Architecture Utilizing High Temperature Superconducting Magnets

Data.gov (United States)

National Aeronautics and Space Administration — This study will explore the effectiveness of using electromagnets to protect a habitat from radiation through active radiation shielding.Active radiation shielding...

Modification of biochemical constituents in the liver of Swiss-albino mice by Vitamin-E against combined administration of lead and radiation

International Nuclear Information System (INIS)

Gajawat, Sunita; Goyal, P.K.

2000-01-01

The estimation of biochemical constituents serves as an ideal parameter to determine the protective efficacy of suitable substances against combined treatment of lead and radiation. Vitamin E prevents elevation in glycogen, cholesterol, acid phosphatase and alkaline phosphatase activity after concomitant treatment of lead and radiation. Thus, it is concluded that the prophylactic application of vitamin E is quite potent during lead intoxication and irradiation

Use of the LIULIN detector for the determination of aircrew radiation exposure

International Nuclear Information System (INIS)

Kitching, F.W.

2004-01-01

As a result of ICRP-60 (1990) recommendations, countries throughout the world have recognized the fact that, as a result of their occupation, aircrew are exposed to levels of radiation higher than that received by the general population. Some countries have implemented legislation to monitor aircrew exposure while others have implemented a system of education by issuing advisories and circulars. In Canada, legislation is not yet in place to ensure that aircrew are properly monitored, but Transport Canada has initiated studies into how the problem of monitoring all aircrew personnel can be effectively and efficiently undertaken. ICRP-60 recommended the use of predictive codes to monitor exposure with the caveat that the code be periodically verified through the use of instrument measurements. In this thesis, three different methods of determining the ambient dose equivalent using the LIULIN instrument are investigated. All three methods require that the quality factor be determined in order to calculate the ambient dose equivalent given the absorbed dose. The first method is dependent upon the aircraft's position (latitude and longitude) and the cut-off rigidity associated with this geographical position. The second method determines a quality factor based on the complete linear energy transfer (LET) spectrum of the incident radiation recorded by the LIULIN. The third method uses probability distribution analysis to determine the dose mean LET, which can also be related to a quality factor. All three methods satisfactorily calculate the ambient dose equivalent when compared with the reference HAWK instrument. The preferred method of determining the ambient dose equivalent was found to be a direct analysis of the LIULIN LET spectrum. As a result of this study, the LIULIN was found to be capable of providing an accurate indication of ambient dose equivalent and can be used for periodic validation of predictive codes. (author)

Involvement of prostaglandins and histamine in radiation-induced temperature responses in rats

International Nuclear Information System (INIS)

Kandasamy, S.B.; Hunt, W.A.

1990-01-01

Exposure of rats to 1-15 Gy of gamma radiation induced hyperthermia, whereas exposure to 20-150 Gy produced hypothermia. Since radiation exposure induced the release of prostaglandins (PGs) and histamine, the role of PGs and histamine in radiation-induced temperature changes was examined. Radiation-induced hyper- and hypothermia were antagonized by pretreatment with indomethacin, a cyclooxygenase inhibitor. Intracerebroventricular administration of PGE2 and PGD2 induced hyper- and hypothermia, respectively. Administration of SC-19220, a specific PGE2 antagonist, attenuated PGE2- and radiation-induced hyperthermia, but it did not antagonize PGD2- or radiation-induced hypothermia. Consistent with an apparent role of histamine in hypothermia, administration of disodium cromoglycate (a mast cell stabilizer), mepyramine (H1-receptor antagonist), or cimetidine (H2-receptor antagonist) attenuated PGD2- and radiation-induced hypothermia. These results suggest that radiation-induced hyperthermia is mediated via PGE2 and that radiation-induced hypothermia is mediated by another PG, possibly PGD2, via histamine

Determination of tolerances of mirror displacement and radiator gas impurity for the CBM RICH detector

Energy Technology Data Exchange (ETDEWEB)

Adamczewski-Musch, J. [GSI Darmstadt (Germany); Becker, K.-H. [University Wuppertal (Germany); Belogurov, S. [ITEP Moscow (Russian Federation); Boldyreva, N. [PNPI Gatchina (Russian Federation); Chernogorov, A. [ITEP Moscow (Russian Federation); Deveaux, C. [University Gießen (Germany); Dobyrn, V. [PNPI Gatchina (Russian Federation); Dürr, M. [University Gießen (Germany); Eom, J. [Pusan National University (Korea, Republic of); Eschke, J. [GSI Darmstadt (Germany); Höhne, C. [University Gießen (Germany); Kampert, K.-H. [University Wuppertal (Germany); Kleipa, V. [GSI Darmstadt (Germany); Kochenda, L. [PNPI Gatchina (Russian Federation); Kolb, B. [GSI Darmstadt (Germany); Kopfer, J. [University Wuppertal (Germany); Kravtsov, P. [PNPI Gatchina (Russian Federation); Lebedev, S.; Lebedeva, E. [University Gießen (Germany); Leonova, E. [PNPI Gatchina (Russian Federation); and others

2014-12-01

The CBM experiment at the future FAIR facility will explore nuclear matter at high net-baryon densities. One of the key observables is di-leptons as they penetrate the created matter without further strong interactions. A gaseous RICH detector in a standard projective geometry using spherical mirrors is one of two detector elements for the required electron identification. The mirror system consists of about 72 trapezoidal mirror tiles. Any misalignment between the tiles relative to the nominal common spherical surface leads to reduction of the reconstruction efficiency of Cherenkov rings and deterioration of their resolution. To determine tolerances in mirror misalignment extensive simulation and measurement studies were carried out. Pure CO{sub 2} will be used as radiator gas. Gas contamination, mainly moisture and Oxygen, reduces the number of detected photons per ring and worsens the quality of reconstructed Cherenkov rings. Therefore a study was carried out to determine tolerances in radiator gas contamination. - Highlights: • Mirror misalignment leads to ring deformation in a RICH detector. • Radiator contamination leads to resolution deterioration of fitted rings. • To determine tolerances measurements and simulations were carried out. • Mirror displacements of up to 0.32 mm at any mirror side can be tolerated. • Oxygen (moisture) contamination of up to 1% (0.0011%) can be safely tolerated.

Study on the most appropriate time for romurtide administration (Nopia) in radiotherapy patients

International Nuclear Information System (INIS)

Yokouchi, Junichi; Hirabayashi, Shoji; Kanesaka, Naoto; Baba, Seiko; Amino, Masayuki; Abe, Kimihiko

1997-01-01

The most appropriate time for administration was studied based on examination of the total number of leukocytes, differential white blood count, and the number of platelets in 30 cases in which 200 μg Romurtide (Nopia) was injected subcutaneously on the day of radiotherapy, 5 times a week, for 2 weeks, totally 10 times because leukopenia was caused during treatment with radiotherapy. It was recognized that the number of leukocytes, mainly neutrophils, increased from 1 week after starting administration of Romurtide to after the completion of administration (2 weeks after administration), except 1 week after completion of administration. The increasing effect in the number of platelets was not recognized, and it had decreased from at the completion of administration to 1 week after the completion of administration of Romurtide. The rate of completion of radiotherapy was 100% without any serious adverse events, but there were 4 cases in which fever was observed. Therefore, it is not very favorable to administer Romurtide immediately after radiation, taking account of the treatment period of radiotherapy. It is also considered that it would be necessary to start radiation after sufficient recovery of the number of leukocytes or increase in their number by using G-CSF preparation in cases in which the leukocyte count has fallen since starting radiation due to the influence of the preceding chemotherapy. (author)

Cell surface appearance of unexpected host MHC determinants on thymocytes from radiation bone marrow chimeras

International Nuclear Information System (INIS)

Sharrow, S.O.; Mathieson, B.J.; Singer, A.

1981-01-01

The phenotypic appearance of cell surface antigens on murine thymocytes from long-term radiation bone marrow chimeras was analyzed using indirect immunofluorescence and flow microfluorometry. Cells maturing in the thymi of these mice were typed for MHC (Kk, I-Ak, H-2b, Kb, and Ib) and non-MHC (Lty 1, Ly 9, and TL) determinants. All cells were of donor origin as determined by non-MHC (Ly) phenotype in P1 leads to P2, P1 x P2 leads to P1, and P1 leads to P2 radiation chimeras. In contrast, the MHC phenotypes of these thymocytes were markedly affected by the host environment. Specifically, H-2 and I-A determinants of both parental phenotypes were detected on thymocytes from P1 leads to P1 x P2 chimeras; I-A determinants of host phenotype were present, whereas I-A determinants of donor phenotype were reduced on thymocytes from P1 x P2 leads to P1 chimeras; and thymocytes from P1 leads to P2 chimeras possessed H-2 and I-A determinants of host phenotype but showed reduction of donor I-A phenotype determinants. The appearance of host cell surface H-2 and I-A determinants on thymocytes from chimeras closely parallels the functional recognition of MHC determinants by T cells from chimeric mice and thus may be significantly related to the development of the self-recognition repertoire by maturing T cells

Radiation physics in medicine and veterinary medicine studies

International Nuclear Information System (INIS)

Popovic, D.; Djuric, G.

2000-01-01

Medical and veterinary medicine staff and specialists represent an important decision making group in national administration and institutions dealing with radiation protection and environmental protection matters in general. Still, their education in physics, especially in radiation physics is fragmentary and loose, both from technical and theoretical point of view. Within medicine and veterinary medicine studies as well as within other biomedical sciences (biology, pharmacology, biotechnology) radiation physics is usually incorporated in the first year curricula as a part of general physics or biophysics course. Some segments of radiation physics mainly as a technical base for different instrumentation methods and techniques could be also found within different graduate and post-graduate courses of radiology, physical therapy, radiation hygiene, environmental protection, etc. But the traditional approach in presenting the matter and inflexibility of the educational system strongly confront the growing public concern for the environmental problems dealing with radiation and demands for better informing and technical education for those involved in informing and administration. This paper considers some of these problems presenting a new approach in education in radiation physics for medical and veterinary medicine students based on education through student projects and work in the field, as well as on the strong collaboration among administration, universities and professional societies on the national and international level. (author)

Morphological Diversity and the Roles of Contingency, Chance and Determinism in African Cichlid Radiations

Science.gov (United States)

Young, Kyle A.; Snoeks, Jos; Seehausen, Ole

2009-01-01

Background Deterministic evolution, phylogenetic contingency and evolutionary chance each can influence patterns of morphological diversification during adaptive radiation. In comparative studies of replicate radiations, convergence in a common morphospace implicates determinism, whereas non-convergence suggests the importance of contingency or chance. Methodology/Principal Findings The endemic cichlid fish assemblages of the three African great lakes have evolved similar sets of ecomorphs but show evidence of non-convergence when compared in a common morphospace, suggesting the importance of contingency and/or chance. We then analyzed the morphological diversity of each assemblage independently and compared their axes of diversification in the unconstrained global morphospace. We find that despite differences in phylogenetic composition, invasion history, and ecological setting, the three assemblages are diversifying along parallel axes through morphospace and have nearly identical variance-covariance structures among morphological elements. Conclusions/Significance By demonstrating that replicate adaptive radiations are diverging along parallel axes, we have shown that non-convergence in the common morphospace is associated with convergence in the global morphospace. Applying these complimentary analyses to future comparative studies will improve our understanding of the relationship between morphological convergence and non-convergence, and the roles of contingency, chance and determinism in driving morphological diversification. PMID:19270732

A Novel Radiation Shielding Material, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — In order to safely explore space, humans must be protected from radiation. There are 2 predominant sources of extraterrestrial ionizing radiation, namely, Galactic...

Recommendations for determining the surface contamination of the skin and estimating radiation exposure of the skin after contamination

International Nuclear Information System (INIS)

1989-01-01

The recommendations are applicable to the determination of surface contaminations of the skin and to the estimation of the expected radiation exposure of the skin of contaminated persons. According to the present recommendations, the radiation exposure can only be estimated for the intact and healthy skin

Production of anti-SRBC antibodies after DDC administration in whole-body irradiated mice

International Nuclear Information System (INIS)

Kautska, J.; Hosek, B.; Misustova, J.

1990-01-01

Production of antibody-forming cells (PFC) was studied in mice subjected to a single whole-body radiation dose of 3.8 Gy following an injection of sodium diethyl dithiocarbamate (DDC, 800 mg/kg) 30 min before irradiation. The animals were immunized (1% SRBC) 4 hours and 5 and 10 days after irradiation, and the number of PFC was determined by a modified Jerne plaque technique on days 4, 7 and 10 after immunization. After irradiation alone, the PFC levels were markedly reduced at all time intervals in comparison with unirradiated controls. Upon immunization of animals on day 10 after irradiation the peak PFC levels were observed on day 7 after immunization in the irradiated only group and in the group irradiated after DDC administration (in controls on day 4 after immunization). The administration of DDC entirely eliminated the unfavourable effect of radiation if immunization was performed 4 h after irradiation, in terms of the number and the peak level of PFC. Upon immunization of animals on day 5 and day 10 after irradiation the PFC levels were not markedly influenced by DDC injection. (author). 3 figs., 25 refs

Factors determining differences in biological effectiveness of ionizing radiations possessing different physical characteristics

International Nuclear Information System (INIS)

Korogodin, V.I.; Krasavin, E.A.

1982-01-01

Radiosensitivity of pro- and eukaryotes (D 0- 1 ) is considered with regard to the linear energy transfer (LET) of ionizing radiations. It was shown that radiosensitivity, as a function of LET, D 0- 1 (LET), is determined by not merely physical characteristics of radiations but also the ability of repair of DNA double strand breaks (DSB). The increase in the radiosensitivity of eukaryotes is connected with the decrease in the DSB repair when cells are exposed to densely ionizing particles. The decrease in DSB repair is apparently connected with the increment of straight DSB, comparing to enzymatic DSB, upon exposure to heavy ions. Potential mechanisms of D 0- 1 (LET) modifications for radiosensitive and superresistant mutants are discussed

Density determination of railroad ballast by means of gamma radiation

International Nuclear Information System (INIS)

Mundt, M.

1983-01-01

Proceeding from the requirements of a measuring method for determining the degrees of densification and of soiling of railroad beds, conclusions are drawn for the use of a radiometric technique, considering measuring geometry, radiation energy, and instrumentation. Results obtained from laboratory experiments with a ballast pressure unit are presented. It is pointed out that the application of radiometric density measurements has to be linked with investigations of the behaviour of the rock species used, in order to obtain a valid interpretation of the measured density with regard to the properties and the composition of the railroad bed. (author)

Nuclear supervision - federal executive administration or federal self-administration. From the view of an optimum task fulfillment

International Nuclear Information System (INIS)

Renneberg, W.

2005-01-01

The problem of the nuclear supervision, i.e. the question wether the federal executive administration can be considered a sustainable concept for the future within the framework of the atomic energy law is discussed in the paper. Without a complete refinancing of the nuclear supervision it is not possible to develop or at least keep a scientific and technical competence within the federal administration. In this context the results of the Kienbaum survey are reported. The objections and concerns with respect to the discussed federal self-administration model as alternative include possibly required changes of the constitutional law, aggravation of the loss of competence, the future of radiation protection, and interfaces to other fields of law, like emergency management

Measuring element for the detection and determination of radiation doses of gamma radiation and neutrons

International Nuclear Information System (INIS)

Jahn, W.; Piesch, E.

1975-01-01

A measuring element detects and proves both gamma and neutron radiation. The element includes a photoluminescent material which stores gamma radiation and particles of arsenic and phosphorus embedded in the photoluminescent material for detecting neutron radiation. (U.S.)

Melanocortin 1 receptor genotype: an important determinant of the damage response of melanocytes to ultraviolet radiation

Science.gov (United States)

Kadekaro, Ana Luisa; Leachman, Sancy; Kavanagh, Renny J.; Swope, Viki; Cassidy, Pamela; Supp, Dorothy; Sartor, Maureen; Schwemberger, Sandy; Babcock, George; Wakamatsu, Kazumasa; Ito, Shosuke; Koshoffer, Amy; Boissy, Raymond E.; Manga, Prashiela; Sturm, Richard A.; Abdel-Malek, Zalfa A.

2010-01-01

The melanocortin 1 receptor gene is a main determinant of human pigmentation, and a melanoma susceptibility gene, because its variants that are strongly associated with red hair color increase melanoma risk. To test experimentally the association between melanocortin 1 receptor genotype and melanoma susceptibility, we compared the responses of primary human melanocyte cultures naturally expressing different melanocortin 1 receptor variants to α-melanocortin and ultraviolet radiation. We found that expression of 2 red hair variants abolished the response to α-melanocortin and its photoprotective effects, evidenced by lack of functional coupling of the receptor, and absence of reduction in ultraviolet radiation-induced hydrogen peroxide generation or enhancement of repair of DNA photoproducts, respectively. These variants had different heterozygous effects on receptor function. Microarray data confirmed the observed differences in responses of melanocytes with functional vs. nonfunctional receptor to α-melanocortin and ultraviolet radiation, and identified DNA repair and antioxidant genes that are modulated by α-melanocortin. Our findings highlight the molecular mechanisms by which the melanocortin 1 receptor genotype controls genomic stability of and the mutagenic effect of ultraviolet radiation on human melanocytes.—Kadekaro, A. L., Leachman, S., Kavanagh, R. J., Swope, V., Cassidy, P., Supp, D., Sartor, M., Schwemberger, S., Babcock, G., Wakamatsu, K., Ito, S., Koshoffer, A., Boissy, R. E., Manga, P., Sturm, R. A., Abdel-Malek, Z. A. Melanocortin 1 receptor genotype: an important determinant of the damage response of melanocytes to ultraviolet radiation. PMID:20519635

Radiation trapping in atomic absorption spectroscopy at lead determination in different matricies

International Nuclear Information System (INIS)

El-Gohary, Z.

2005-01-01

The determination of lead by flame atomic absorption analysis in the presence of Sn and Fe atoms and different matrices such as OH and SO 3 was investigated with the objective of understanding the spectral interference processes at the analytical lines 283.31 nm for a wide range of concentration. The radiation trapping factor was interpreted and evaluated assuming Voigt distribution of the atomic and rotational lines in the flame. The radiation trapping factor was increased by increasing the number density (plasma of the absorbing medium is optically thick). In plasma, there is a certain point of equilibrium between the trapping and the escaping of radiation, which is relevant to 50% of absorption. The spectral background interference can cause a variation of the number density at equilibrium point as a result of the degree of overlap with the analytical line. The spectral background interference can be easily avoided by using another resonance absorption line for the analysis. The chemical modification of the matrix is applied to minimize the interference effect. Nitric acid, ammonium nitrate and magnesium nitrate are most commonly recommended as matrix modifiers

Determining Daily Radiation Interception in a Semiarid Inter ...

African Journals Online (AJOL)

... in soil-plant-atmosphere continuum, as net radiation is a major part of the energy balance. ... Africa, where solar radiation is not a limiting factor for plant growth. The results suggested that ... Metrics Loading ... Metrics powered by PLOS ALM

Reference beta radiations for calibrating dosemeters and dose ratemeters and for determining their response as a function of beta radiation energy. 1. ed.

International Nuclear Information System (INIS)

1984-01-01

This International Standard specifies the requirements for reference beta radiations produced by radionuclide sources to be used for the calibration of protection level dosemeters and dose ratemeters, and for the determination of their response as a function of beta energy. It gives the characteristics of radionuclides which have been used to produce reference beta radiations, gives examples of suitable source constructions and describes methods for the measurement of the residual maximum beta energy and the absorbed dose rate at a depth of 7 mg·cm -2 in a semi-infinite tissue-equivalent medium. The energy range involved lies between 66 keV and 3.6 MeV and the absorbed dose rates are in the range from about 10 μGy·h -1 (1 mrad·h -1 ) to at least 10 Gy·h -1 (10 3 rad·h -1 ). This International Standard proposes two series of beta reference radiations from which the radiation necessary for determining the characteristics (calibration and energy response) of an instrument shall be selected. Series 1 reference radiations are produced by radionuclide sources used with beam flattening filters designed to give uniform dose rates over a large area at a specific distance. The proposed sources of 90 Sr+ 90 Y, 204 TI and 147 Pm produce maximum dose rates of approximately 5mGy·h -1 (0.5 rad·h -1 ). Series 2 reference radiations are produced without the use of beam flattening filters which allows a range of source-to-calibration plane distances to be used. Close to the sources only relatively small areas of uniform dose rate are produced but this Series has the advantage of extending the energy and dose rate ranges beyond those of Series 1. The radionuclides used are those of Series 1 with the addition of the radionuclides 14 C and 106 Ru+ 106 Rh; these sources produce dose rates of up to 10 Gy·h -1 (10 3 rad·h -1 )

Natural Products Garlic Oil and Vitamin E, Control Radiation Induced Disorders of Lipid and Carbohydrate Metabolism in Rats

International Nuclear Information System (INIS)

Ragab, E.A.; Ashry, O.M.

2004-01-01

Increased level of lipid peroxides in various tissues of irraiated animals, may play a crucial role in determining the pathogenesis of radiation exposure. Many of the damaging effects of ionizing radiation are mediated by reactive free radicals. The efficacy of oral treatment of rats with garlic oil (100 mg/kg body weight) for ten days and intraperitoneal administration of vitamin E (100mg/kg body wt.) two hours before whole body gamma irradiation (7Gy), was examine on certain biochemical parameters. The data obtained revealed that, radiation exposure caused increase in serum malondialdehyde level (indicating lipid peroxiation accompanied by increase in serum total lipid, trigacylglycerol, cholesterol an low density lipoprotein with significant decrease in high density lipoprotein. Radiation exposure also induced significant elevation in serum glucose level, liver glycogen and liver glucose 6-phosphatase activity level. Administration of the natural product (garlic oil) and /or vitamin E ameliorates the radiation inuced disturbances in lipid and carbohydrate metabolism. The study confirmed the beneficial role of the used antioxidative agents as recommended radioprotectors due to their ability of scavenging free radicals produced by ionizing radiation or oxidative stress

Administration of the Radiation Control for Health and Safety Act of 1968, Public Law 90-602, April 1, 1975. Annual report, Jan--Dec 1974

International Nuclear Information System (INIS)

1974-01-01

The Secretary of Health, Education, and Welfare is required, Subpart 3, Section 2, Part F of Title III of the Public Health Service Act; 42 USC et seq. (Public Law 90-602), to submit an annual report to the President for transmittal to the Congress on or before April 1 on the adminstration of the Radiation Control for Health and Safety Act. The detailed information required to be included in the report is outlined in Section 360D of Public Law 90-602. The Food and Drug Administration, through its Bureau of Radiological Health, has been delegated the authority for the day-to-day administration of the Act. This report covers the detailed operation of the Agency in carrying out that responsibility for calendar year 1974

Thioredoxin mitigates radiation-induced hematopoietic stem cell injury in mice

Directory of Open Access Journals (Sweden)

Pasupathi Sundaramoorthy

2017-11-01

Full Text Available Abstract Background Radiation exposure poses a significant threat to public health. Hematopoietic injury is one of the major manifestations of acute radiation sickness. Protection and/or mitigation of hematopoietic stem cells (HSCs from radiation injury is an important goal in the development of medical countermeasure agents (MCM. We recently identified thioredoxin (TXN as a novel molecule that has marked protective and proliferative effects on HSCs. In the current study, we investigated the effectiveness of TXN in rescuing mice from a lethal dose of total body radiation (TBI and in enhancing hematopoietic reconstitution following a lethal dose of irradiation. Methods We used in-vivo and in-vitro methods to understand the biological and molecular mechanisms of TXN on radiation mitigation. BABL/c mice were used for the survival study and a flow cytometer was used to quantify the HSC population and cell senescence. A hematology analyzer was used for the peripheral blood cell count, including white blood cells (WBCs, red blood cells (RBCs, hemoglobin, and platelets. Colony forming unit (CFU assay was used to study the colongenic function of HSCs. Hematoxylin and eosin staining was used to determine the bone marrow cellularity. Senescence-associated β-galactosidase assay was used for cell senescence. Western blot analysis was used to evaluate the DNA damage and senescence protein expression. Immunofluorescence staining was used to measure the expression of γ-H2AX foci for DNA damage. Results We found that administration of TXN 24 h following irradiation significantly mitigates BALB/c mice from TBI-induced death: 70% of TXN-treated mice survived, whereas only 25% of saline-treated mice survived. TXN administration led to enhanced recovery of peripheral blood cell counts, bone marrow cellularity, and HSC population as measured by c-Kit+Sca-1+Lin– (KSL cells, SLAM + KSL cells and CFUs. TXN treatment reduced cell senescence and radiation

Association between workarounds and medication administration errors in bar-code-assisted medication administration in hospitals

NARCIS (Netherlands)

van der Veen, Willem; van den Bemt, Patricia M L A; Wouters, Hans; Bates, David W; Twisk, Jos W R; de Gier, Johan J; Taxis, Katja

Objective: To study the association of workarounds with medication administration errors using barcode-assisted medication administration (BCMA), and to determine the frequency and types of workarounds and medication administration errors. Materials and Methods: A prospective observational study in

Ultraviolet radiation, measurements and safety evaluations for radiation protection purposes

International Nuclear Information System (INIS)

Witew, B.; Fischer, P.G.

1983-01-01

In order to evaluate the effects of ultraviolet radiation, one has to study that photobiologically effective radiation which induces a just measurable threshold reaction. For practical radiation protection, one has to determine the permissible duration of exposure at the end of which the threshold reaction is induced. This time limit is derived by means of spectral measurements and determination of radiation intensity. Detrimental photobiological effects can be avoided, and favourable effects optimized, by observing the time limit. Thus these measurements are used to determine the threshold at which the desired effects of ultraviolet radiation will be accompanied by unwanted effects or damage to persons, as for instance in the use of ultraviolet radiation for operating room sterilization, arc welding work, or cosmetic purposes. (orig.) [de

A Logic for Inclusion of Administrative Domains and Administrators in Multi-domain Authorization

Science.gov (United States)

Iranmanesh, Zeinab; Amini, Morteza; Jalili, Rasool

Authorization policies for an administrative domain or a composition of multiple domains in multi-domain environments are determined by either one administrator or multiple administrators' cooperation. Several logic-based models for multi-domain environments' authorization have been proposed; however, they have not considered administrators and administrative domains in policies' representation. In this paper, we propose the syntax, proof theory, and semantics of a logic for multi-domain authorization policies including administrators and administrative domains. Considering administrators in policies provides the possibility of presenting composite administration having applicability in many collaborative applications. Indeed, administrators and administrative domains stated in policies can be used in authorization. The presented logic is based on modal logic and utilizes two calculi named the calculus of administrative domains and the calculus of administrators. It is also proved that the logic is sound. A case study is presented signifying the logic application in practical projects.

ACTIONS OF THE ADMINISTRATION OF THE FEDERAL SERVICE FOR SURVEILLANCE ON CONSUMER RIGHTS PROTECTION AND HUMANWELL-BEING IN KAMCHATSKY KRAI AND FEDERAL HEALTH ORGANIZATION"CENTER OF HYGIENE AND EPIDEMIOLOGYIN THE KAMCHATSKY KRAI" FOR RADIATION PROTECTION OF THE POPULATION IN CONNECTION WITH THE FUKUSHIMA ACCIDENT

Directory of Open Access Journals (Sweden)

N. I. Zhdanova

2011-01-01

Full Text Available The article describes actions of the Administration of the Federal Service for Surveillance on Consumer Rights Protection and Human Well-being in KamchatskyKrai and the Federal Health Organization "Center of Hygiene and Epidemiology in the Kamchatsky Krai" to ensure radiation protection of the population in conditions of the radiation accident at Fukushima nuclear power plant and their co-operation with other regional administrations in solution of this problem. The article also presents results of radiation monitoring in the region and shows absence of any significant radiation exposure to the population of the region resulting from the Fukushima nuclear power plant accident.

Determination of half-value layers and tenth-value layer to barite as shielding against X radiation in radiological protection

International Nuclear Information System (INIS)

Lopes, G.A.; Aragao Filho, G.L.; Almeida Junior, A.T.; Santos, M.A.P.; Araujo, F.G.S.; Nogueira, M.S.

2013-01-01

The barium mortar has been widely used as radiation shielding material for X and gamma radiations in Brazil, by presenting some advantages as the high rate of efficiency in radiation shielding, the easy handling and application, the facility to be found in the national market and low cost. The determination of the half-value layers (HVL) and tenth-value layer (TVL) of different types of barite becomes the major factor to characterize the attenuation of these materials, in order to ensure the efficiency and quality of projects shielding, by ensuring the safety of workers occupationally exposed to radiation and of individuals to the public. Thus, plates of different thickness of mortar of barite were made for determination of their HVL and TVL. The plates were irradiated with X-ray qualities for radiological protection according to standard ISO 4037. A system of CdTe spectrometry was used to acquire spectra transmitted, in the presence of each plate, and their combinations. The areas of the spectra obtained, depending on the total thickness of the plates used in the arrangement were used to determine the attenuation curves. From these curves obtained in this work was to establish the HVL and TVL

Determining the infrared radiative effects of Saharan dust: a radiative transfer modelling study based on vertically resolved measurements at Lampedusa

Science.gov (United States)

Meloni, Daniela; di Sarra, Alcide; Brogniez, Gérard; Denjean, Cyrielle; De Silvestri, Lorenzo; Di Iorio, Tatiana; Formenti, Paola; Gómez-Amo, José L.; Gröbner, Julian; Kouremeti, Natalia; Liuzzi, Giuliano; Mallet, Marc; Pace, Giandomenico; Sferlazzo, Damiano M.

2018-03-01

Detailed measurements of radiation, atmospheric and aerosol properties were carried out in summer 2013 during the Aerosol Direct Radiative Impact on the regional climate in the MEDiterranean region (ADRIMED) campaign in the framework of the Chemistry-Aerosol Mediterranean Experiment (ChArMEx) experiment. This study focusses on the characterization of infrared (IR) optical properties and direct radiative effects of mineral dust, based on three vertical profiles of atmospheric and aerosol properties and IR broadband and narrowband radiation from airborne measurements, made in conjunction with radiosonde and ground-based observations at Lampedusa, in the central Mediterranean. Satellite IR spectra from the Infrared Atmospheric Sounder Interferometer (IASI) are also included in the analysis. The atmospheric and aerosol properties are used as input to a radiative transfer model, and various IR radiation parameters (upward and downward irradiance, nadir and zenith brightness temperature at different altitudes) are calculated and compared with observations. The model calculations are made for different sets of dust particle size distribution (PSD) and refractive index (RI), derived from observations and from the literature. The main results of the analysis are that the IR dust radiative forcing is non-negligible and strongly depends on PSD and RI. When calculations are made using the in situ measured size distribution, it is possible to identify the refractive index that produces the best match with observed IR irradiances and brightness temperatures (BTs). The most appropriate refractive indices correspond to those determined from independent measurements of mineral dust aerosols from the source regions (Tunisia, Algeria, Morocco) of dust transported over Lampedusa, suggesting that differences in the source properties should be taken into account. With the in situ size distribution and the most appropriate refractive index the estimated dust IR radiative forcing

Individualized determination of lower margin in pelvic radiation field after low anterior resection for rectal cancer resulted in equivalent local control and radiation volume reduction compared with traditional method

International Nuclear Information System (INIS)

Park, Suk Won; Ahn, Yong Chan; Huh, Seung Jae; Chun, Ho Kyung; Kang, Won Ki; Kim, Dae Yong; Lim, Do Hoon; Noh, Young Ju; Lee, Jung Eun

2000-01-01

When determining the lower margin of post-operative pelvic radiation therapy field according to the traditional method (recommended by Gunderson), the organs located in the low pelvic cavity and the perineum are vulnerable to unnecessary radiation. This study evaluated the effect of individualized determination of the lower margin at 2 cm to 3 cm below the anastomotic site on the failure patterns. Authors included 88 patients with modified Astler-Coller (MAC) stages from B2 through C3, who received low anterior resection and post-operative pelvic radiation therapy from Sept. 1994 to May 1998 at Samsung Medical Center, Sungkyunkwan University. The numbers of male and female patients were 44 and 44, and the median age was 57 years (range: 32-81 years). Three field technique (posterior-anterior and bilateral portals) by 6, 10, 15 MY X-rays was used to deliver 4,500 cGy to the whole pelvis followed by 600 cGy's small field boost to the tumor bed over 5.5 weeks. Sixteen patients received radiation therapy by traditional field margin determination, and the lower margin was set either at the low margin of the obturator foramen or at 2 cm to 3 cm below the anastomotic site, whichever is lower. In 72 patients, the lower margin was set at 2 cm to 3 cm below the anastomotic site, irrespectively of the obturator foramen, by which the reduction of radiation volume was possible in 55 patients (76%). Authors evaluated and compared survival, local control, and disease-free survival rates of these two groups. The median follow-up period was 27 months (range: 7-58 months). MAC stages were B2 in 32 (36%) , B3 in 2 (2%), C1 in 2 (2%), C2 in 50 (57%), and C3 in 2 (2%) patients, respectively. The entire patients' overall survival rates at 2 and 4 years were 94% and 68%, respectively, and disease-free survival rates at 2 and 4 years were 86% and 58%, respectively. The first failure sites were local only in 4, distant only in 14, and combined local and distant in 1 patient, respectively

Improved Metal-Polymeric Laminate Radiation Shielding, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — In this proposed Phase I program, a multifunctional lightweight radiation shield composite will be developed and fabricated. This structural radiation shielding will...

Radiation protection for nurses. Regulations and guidelines

International Nuclear Information System (INIS)

Jankowski, C.B.

1992-01-01

Rules and regulations of federal agencies and state radiation protection programs provide the bases for hospital policy regarding radiation safety for nurses. Nursing administrators should work with the radiation safety officer at their institutions to ensure that radiation exposures to staff nurses will be as low as reasonably achievable and that special consideration will be given to pregnant nurses. Nurses' fears about their exposure to radiation can be greatly reduced through education

Consequences of the new radiation protection law on the radiation protection register and the occupational radiation protection; Auswirkungen des neuen Strahlenschutzgesetzes auf das Strahlenschutzregister und die berufliche Strahlenueberwachung

Energy Technology Data Exchange (ETDEWEB)

Frasch, Gerhard

2017-08-01

The implementation of the guideline 2013/59/EURATOM has been performed in the new radiation protection law. The most important consequences of the new radiation protection law for the occupational radiation protection are the following: the introduction of an explicit personal indicator and the actualization of occupational categories for employees. These facts require technical and administrative reorganization in data transmission of the licensee to the regulatory monitoring executive and the radiation protection register.

Opportunities and limits in applying epidemiologic methods to determine the effects of ionizing radiation in humans

International Nuclear Information System (INIS)

Lilienfeld, A.M.

1980-01-01

In this presentation, an attempt has been made to indicate rather broadly some of the opportunities and limits of the epidemiologic studies of ionizing radiation effects. The review has not been exhaustive. However, it is clear that much further information is needed before estimates of radiation effects can be made with the kind of confidence that one desires. These scientific considerations should be divorced from the policy considerations where a more conservative attitude would appear desirable. Epidemiologic studies now in progress should be continued on the survivors in Hiroshima and Nagasaki. An attempt should be made to locate other exposed groups in order to obtain information to determine the types and frequencies of malignancies and other possible effects. In epidemiologic studies of the effect of radiation, there should be incorporated mechanisms for obtaining information on other possible carcinogenic factors to detemine the possible effects of interaction between radiation and these other factors. Conversely, in studies of other types of carcinogenic agents, data on radiation exposure should also be obtained. To increase the value of such studies, it is important to develop a standardized method of obtaining information on radiation exposure as well as some means of categorizing such exposure

Effect of the route of administration on the biodistribution of radioiodinated OV-TL 3 F(ab')2 in experimental ovarian cancer

International Nuclear Information System (INIS)

Tibben, J.G.; Massuger, L.F.A.G.; Boerman, O.C.; Borm, G.F.; Claessens, R.A.M.J.; Corstens, F.H.M.

1994-01-01

The effect of the route administration on the distribution of radioiodinated OV-TL 3 F(ab') 2 was studied in Balb/c female mice with intraperitoneal or subcutaneous ovarian carcinoma xenografts. In the intraperitoneal tumour model in which both ascites and solid tumour deposits were present, intraperitoneal administration resulted in a lower estimated radiation dose to blood as compared with intravenous administration. In this model normalization to equal estimated radiation doses to blood for both routes of administration indicated that a twice as high estimated radiation dose can be guided to solid intraperitoneal tumour deposits following intraperitoneal administration. Evacuation of ascitic tumour cells prior to monoclonal antibody injection further increased the estimated radiation dose to solid intraperitoneal tumour deposits following intraperitoneal delivery. Following simultaneous intravenous and intraperitoneal injection of the monoclonal antibody, tissue uptake showed no relevant differences in the subcutaneous tumour model. Overall, the intraperitoneal route of administration was found to be the best choice for therapeutic delivery of iodine-131 labelled monoclonal antibodies. (orig.)

Absorbed radiation to the nuclear medicine nurses from patients administered 201Tl and 99mTc- MIBI

International Nuclear Information System (INIS)

Sattari, Ali; Dadashzadeh, Simin; Nasiroghli, G.; Firoozabadi, Hasan

2008-01-01

People who have administrated radiopharmaceuticals could be a source of radiation to their relatives, medical nurses, and people who have contact them. In this study, the dose rates at various distances of 5, 10,50 and 100 cm from 70 patients, who were administered diagnostic amounts of 201 Tl -Chloride and 99m Tc -MIBI, was measured using an ionization chamber. For determination of external radiation dose to the nurses the radiations in three deferent interval times have measured. The maximum values of external dose rates of 201 Tl and 99m Tc-MIBI were 11.2μSv/h ±2.3 and 43.1μSv/h ±11.9 respectively at 5 cm from the patients. Significant exposure from patients after injection of 99m Tc -MIBI was limited on the day of administration. Departure doses rate of 201 Tl fell gradually so by 3 days after administration was significant. Maximum and average absorbed dose of nuclear medicine staff for one 201 Tl scan was 4.6 and 2.7μSv/h, and for 99m Tc-MIBI was 18.1 and 9.8μSv/h in a working day. (author)

7 CFR 1467.2 - Administration.

Science.gov (United States)

2010-01-01

... 7 Agriculture 10 2010-01-01 2010-01-01 false Administration. 1467.2 Section 1467.2 Agriculture... AGRICULTURE LOANS, PURCHASES, AND OTHER OPERATIONS WETLANDS RESERVE PROGRAM § 1467.2 Administration. (a) The... organizations in program administration. No determination by these agencies or organizations shall compel NRCS...

Radiation doses in pediatric radiology: influence of regulations and standards

International Nuclear Information System (INIS)

Suleiman, O.H.

2004-01-01

The benefits of X-ray examinations contribute to the quality of modern medicine; however the risk of using X-rays, a carcinogen, has always been a concern. This concern is heightened for pediatric patients, who have a much greater sensitivity to the carcinogenic effects of radiation than adults. The principle of as low as reasonably achievable, or ALARA, is essential for minimizing the radiation dose patients receive, especially for pediatric patients. In order to keep radiation doses ALARA, one must know the dose patients receive. The determination of radiation dose in a standard way is therefore necessary so that these doses can be compared with practice, and for meaningful comparison against voluntary standards. In extreme situations, where public health needs may require mandatory standards, or regulations, the quantitative measurement and calculation of radiation dose becomes essential. How some radiation dose metrics and standards have evolved, including the value of different metrics such as entrance air kerma, organ dose, and effective dose will be presented. Recent pediatric X-ray studies, whether or not dedicated pediatric equipment is necessary, and recent initiatives by the Food and Drug Administration for pediatric population will be discussed. (orig.)

Study on combined effects of radiation and bleomycin on carcinoma of tongue iduced by DMBA in hamster

International Nuclear Information System (INIS)

Kitamura, Nobuyasu

1979-01-01

Carcinoma of the tongue (Mostly squamous cell carcinoma) was induced in hamsters by 9,10-dimethyl-1, 2-benzanthracene (DMBA). The amount of various kinds of free radicals, which increased due to radioactive radiation and administration of bleomycin (BLM) in tongue and liver tissues, was determined by an electron spin resonance method. The hamsters were separated into seven groups: BLM administration only (group A 1 ), 60 Co-γ-ray irradiation only (A 2 ), 60 Co-γ-ray irradiation 30 min after BLM administration (A 3 ), BLM administration 30 min after 60 Co-γ-ray irradiation (A 4 ), 60 Co-γ-ray irradiation 24 h after BLM administration (A 5 ), BLM administration 24 h after 60 Co-γ-ray irradiation (A 6 ), and the control (A 7 ). Mean free radicals in the groups were compared, using samples fixed 5 min after treatment. The ratio of mean free radicals of carcinoma of the tongue were 2.6, 2.9, 3.7, 3.9, 3.0, 3.2, and 1 in A 1 , A 2 , A 3 , A 4 , A 5 , A 6 , and A 7 . The ratio of mean free radicals of the liver under the same condition were 1.5, 1.6, 3.3, 3.8, 2.2, 2.6, and 1. A combination of BLM and radioactive radiation increased the amount of free radicals in carcinoma of the tongue and in the liver. Especially BLM administration 30 min after 60 Co-γ-ray irradiation showed a synergistic effect. Judging from the amount of free radicals determined, the effect of radioactive irradiation increased when combined with BLM administration. BLM was most effective when it was administered 5 min after radioactive irradiation. (Tsunoda, M.)

Claudin-3 expression in radiation-exposed rat models: A potential marker for radiation-induced intestinal barrier failure

Energy Technology Data Exchange (ETDEWEB)

Shim, Sehwan; Lee, Jong-geol; Bae, Chang-hwan; Lee, Seung Bum [National Radiation Emergency Medical Center, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Jang, Won-Suk; Lee, Sun-Joo [Laboratory of Experimental Pathology, Korea Cancer Center Hospital, Seoul (Korea, Republic of); Lee, Seung-Sook [National Radiation Emergency Medical Center, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Department of Pathology, Korea Cancer Center Hospital, Seoul (Korea, Republic of); Park, Sunhoo, E-mail: sunhoo@kcch.re.kr [National Radiation Emergency Medical Center, Korea Institute of Radiological and Medical Sciences, Seoul (Korea, Republic of); Department of Pathology, Korea Cancer Center Hospital, Seoul (Korea, Republic of)

2015-01-02

Highlights: • Irradiation increased intestinal bacterial translocation, accompanied by claudin protein expression in rats. • Neurotensin decreased the bacterial translocation and restored claudin-3 expression. • Claudin-3 can be used as a marker in evaluating radiation induced intestinal injury. - Abstract: The molecular events leading to radiation-induced intestinal barrier failure are not well known. The influence of the expression of claudin proteins in the presence and absence of neurotensin was investigated in radiation-exposed rat intestinal epithelium. Wistar rats were randomly divided into control, irradiation, and irradiation + neurotensin groups, and bacterial translocation to the mesenteric lymph node and expression of claudins were determined. Irradiation led to intestinal barrier failure as demonstrated by significant bacterial translocation. In irradiated terminal ilea, expression of claudin-3 and claudin-4 was significantly decreased, and claudin-2 expression was increased. Administration of neurotensin significantly reduced bacterial translocation and restored the structure of the villi as seen by histologic examination. Among the three subtype of claudins, only claudin-3 expression was restored. These results suggest that the therapeutic effect of neurotensin on the disruption of the intestinal barrier is associated with claudin-3 alteration and that claudin-3 could be used as a marker in evaluating radiation-induced intestinal injury.

Thermal Vacuum Verification of Origami Inspired Radiators

Data.gov (United States)

National Aeronautics and Space Administration — This effort seeks to provide a unique means of modulating the waste thermal energy radiated by a radiator, and represents a restart of the FY17 effort that had to be...

Radiation conditions for computerized tomography: determination and comparison

International Nuclear Information System (INIS)

Andrade, Lucio das Chagas de

2016-01-01

Radiology is the practice in which radiation beams, usually radiation X are used to produce an image of the human body in order to obtain a diagnosis, for example, to evaluate a pathological condition by computerized tomography (CT). Although the computerized tomography diagnostic potential is unquestionable, caution must be taken because the doses are almost always higher than the observed in conventional radiology procedures. The ionization chamber used for dosimetry in CT is a unsealed cylindrical chamber with 10 cm and 15 cm of sensitive length. A typical characteristics of this camera is its uniform response to radiation incident at all angles around its axis. The revised edition of IEC 61267 (2005) brought as an innovation the radiation conditions for computed tomography, RQT, that simulate non-attenuated beam and are used in special CT applications. This study aims to establish the necessary conditions to obtain radiation pattern beam computed tomography, RQT, and a calibration laboratory implementation for pencil ionization chambers used in the beam dosimetry produced by these scanners in the Metrology National Laboratory of Ionizing Radiation (LNMRI). In the implementation of RQT conditions we were found that the ratio of kerma rates in the air, with or without additional filtration equivalent to the first HVL (half-value layer), are in accordance with IEC 61267 (2005), which provides a range between 48.5% and 51.5% for each quality. The LNMRI characterized the radiation conditions of RQT series (IEC, 2005), obtaining a percentage of 49.6% for the RQT 8, 50% for the RQT 9 and 50,4% for the RQT 10. With the substitution of the total additional filtration RQT qualities, composed by Al + Cu and by a total filtration composed by copper (Cu) only, it can be seen the emergence of a similar RQT quality named Quality Copper Tomography - QCT. The results of the calibration, the RQT and QCT qualities, had expanded uncertainties with a confidence level 95.45%, less

Reduction of radiation effects by chemical protector (WR-2721)

International Nuclear Information System (INIS)

Lee, C.H.; Kim, Y.K.; Yun, T.K.; Koh, J.H.

1985-01-01

As a part studies on effect of radiation, the present report was carried out to evaluate the changes of leukocytes, lymphocytes percent of leukocytes and several organs in swiss webster (NIH-GP) mice by radiation protective agents prior to γ-ray exposure. The whole body irradiation after administration of a radiation protective agents was done in dose level of 25,50,100 and 300 rads by a single exposure of γ-ray delivered from 60 Co, source tele-irradiation unit at a dose rate of 100 rad/min. Mice of each experimental group were whole body γ-irradiated in plastic cage with special producted rotating machine. The radiation protective agent was employed WR-2721 and the amounts injected intraperitoneally were 400mg/kg of body weight. The leukocytes were counted with hemocytometer. Differential count of leukocytes was done with 200 cells every smear and lymphocyte percent of leukocyte were determined in relative proportion only. All major organ were examined grossly and weighted. After fixation with formalin solution, histo-pathological preparations were made for microscopical study. (Author)

Evaluation of texaphyrins as tumor selective radiation sensitizers

International Nuclear Information System (INIS)

Qing Fan; Woodburn, Kathryn W.; Young, Stuart W.

1997-01-01

Texaphyrins are expanded porphyrin macrocycles that selectively localize and are retained in cancerous lesions. The function of the texaphyrin can be manipulated by the incorporation of different metal ions into the macrocycle's central cavity. Gadolinium texaphyrin (Gd-Tex) and lutetium texaphyrin (Lu-Tex) were evaluated as radiation sensitizers. Radiation sensitization studies were performed using SMT-F and EMT6 mammary tumor-bearing mice. Single and multifraction dose regimens were performed. SMT-F bearing DBA/2N mice and EMT6 bearing Balb/c mice were intravenously administered with Gd-Tex of Lu-Tex (5-40 μmol/kg) 30 minutes to 5 hours prior to radiation (10-50 Gray) for the single fraction studies. The more radioresistant EMT-6 sarcoma model was used for the multifraction studies. The tumor bearing animals were injected with Gd-Tex (5, 20, or 40 μmol/kg) to 2 hours prior radiation (1, 2, or 4 Gray), this regimen was performed for five consecutive days. Gd-Tex is paramagnetic and has a strong fluorescence signal. Tumor selectivity was determined by MRI and fluorescence spectral imaging before and up to 24 hours following the administration of Gd-Tex. Gd-Tex but not Lu-Tex, proved to be an effective radiation sensitizer. Administration of Gd-Tex (40 μmol/kg) prior to a single dose of 30 Gray radiation provided a significant improvement in survival in SMT-F-bearing DBA/2N mice as compared to animals receiving radiation alone (p = 0.0034). A significant radiation sensitization effect was also found in multiple fraction studies (five consecutive days) with Balb/C mice bearing EMT-6 neoplasma-- following 1 Gray of radiation for 5 days there was a significant difference between the 20 and 40 μmol/kg group and controls (p = 0.003, p = 0.005 respectively). MRI and fluorescence spectral imaging studies of tumor bearing animals revealed excellent contrast enhancement of the tumor which persisted up to 24 hours. Texaphyrins localize in neoplasms as visualized using MRI

7 CFR 633.3 - Administration.

Science.gov (United States)

2010-01-01

... 7 Agriculture 6 2010-01-01 2010-01-01 false Administration. 633.3 Section 633.3 Agriculture... AGRICULTURE LONG TERM CONTRACTING WATER BANK PROGRAM § 633.3 Administration. (a) The regulations in this part... administration and related policy matters. No determination by the State Technical Committee shall compel the...

Surface Radiation Budget (SURFRAD) Network 1-Hour Observations

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Radiation measurements at SURFRAD stations cover the range of the electromagnetic spectrum that affects the earth/atmosphere system. Direct solar radiation is...

Assessment of background gamma radiation and determination of excess lifetime cancer risk in Sabzevar City, Iran in 2014

Directory of Open Access Journals (Sweden)

Akbar Eslami

2016-01-01

Full Text Available Background: Background gamma radiation levels vary in different locations and depended on many factors such as radiation properties of soil, building materials as well as construction types which human lives on it. People are always exposed to ionizing radiation, which could badly influence their health. The aim of this study was to evaluate the background gamma-ray dose rate and the estimated annual effective dose equivalent and determination of excess lifetime cancer risk in Sabzevar City, Iran. Methods: The aim of this cross-sectional study was to determine the dose rate of background gamma radiation in outdoor an indoor areas, 26 stations were selected using the map of the Sabzevar City. The amount of gamma radiation was measured at 4 months (September to January in 2014 year. The dosimeter used in this study was a survey meter, that is designed for monitoring radiation of x, gamma and beta rays. Results: The obtained results show that there are significant differences between the indoor and outdoor exposures (P> 0.05. We did not observe significant differences between the time of sampling and sampling locations, (P<0.05. The minimum and maximum values of dose rate were found 66±20 nSvh-1 and 198±28 nSvh-1. The annual effective dose for Sabzevar residents was estimated to be 0.85 mSv and also the amount of excess lifetime cancer risk was estimated 3.39×10-3. Conclusion: According to the results, the excess lifetime cancer risk and the annual effective dose for the Sabzavar City residents due to the background gamma radiation was higher than the global average (0.5 mSv. The epidemiological studies have been proposed to evaluate the risk of chronic diseases associated with natural radiation exposure among residents.

Pulsed neutron well logging apparatus having means for determining background radiation

International Nuclear Information System (INIS)

Randall, R.R.

1979-01-01

A neutron generator in a well logging instrument is periodically pulsed and has an off period between pulses of 1000 microseconds. A neutron detector is gated on at intervals of 400 to 500, 550 to 650, and 700 to 800 microseconds, respectively, following the termination of each burst of fast neutrons. Circuitry is provided for determining the background radiation by the equation: B = N 1 X N 3 - N 2 2 /N 1 + N 3 - 2N 2 where B is the background, and N 1 , N 2 and N 3 are the counts observed during the three gates, respectively. Circuitry is also provided for determining the macroscopic absorption (Σ) from the equation: Σ = 1/VΔt Log [N 1 - B/N 2 - B] where V is the velocity of thermal neutrons, being a constant and Δt represents an increment of time

Extensive and equivalent repair in both radiation-resistant and radiation-sensitive E. coli determined by a DNA-unwinding technique

International Nuclear Information System (INIS)

Ahnstroem, G.; George, A.M.; Cramp, W.A.

1978-01-01

The extent of strand breakage and repair in irradiated E. coli B/r and Bsub(s-l) was studied using a DNA-unwinding technique in denaturing conditions of weak alkali. Although these two strains showed widely different response to the lethal effects of ionizing radiation, they both had an equal capacity to repair radiation-induced breaks in DNA. Oxygen enhancement ratios for the killing of B/r and Bsub(s-l) were respectively 4 and 2; but after repair in non-nutrient or nutrient post-irradiation conditions, the oxygen enhancement values for the residual strand breaks were always the same for the two strains. The equal abilities of E.coli B/r and E.coli Bsub(s-l) to remove the strand breaks measured by this weak-alkali technqiue has led to the suggestion that some other type of damage to either DNA or another macromolecule may play a major role in determining whether or not the cells survive to proliferate. (author)

Extensive and equivalent repair in both radiation-resistant and radiation-sensitive E. coli determined by a DNA-unwinding technique

Energy Technology Data Exchange (ETDEWEB)

Ahnstroem, G [Stockholm Univ. (Sweden); George, A M; Cramp, W A

1978-10-01

The extent of strand breakage and repair in irradiated E. coli B/r and Bsub(s-l) was studied using a DNA-unwinding technique in denaturing conditions of weak alkali. Although these two strains showed widely different response to the lethal effects of ionizing radiation, they both had an equal capacity to repair radiation-induced breaks in DNA. Oxygen enhancement ratios for the killing of B/r and Bsub(s-l) were respectively 4 and 2; but after repair in non-nutrient or nutrient post-irradiation conditions, the oxygen enhancement values for the residual strand breaks were always the same for the two strains. The equal abilities of E.coli B/r and E.coli Bsub(s-l) to remove the strand breaks measured by this weak-alkali technqiue has led to the suggestion that some other type of damage to either DNA or another macromolecule may play a major role in determining whether or not the cells survive to proliferate.

Histopathological changes induced by Electromagnetic Radiation on Rat changes induced by Electromagnetic Radiation on Rat Skin before and after Silymarin and Vitamin E treatment

International Nuclear Information System (INIS)

Ibrahim, N.F.; Elkady, A.

2013-01-01

People in industrial and developing countries are exposed to large variety of environmental influencing agents including chemical, air, water and food pollution. Also physical harmful agents such as ultraviolet radiation, and electromagnetic radiation especially by cell phones. Our aim in this study was to investigate the effect of electromagnetic radiation on the skin of male albino rats and the role of silymarin and Vitamin E as skin protectors. The male rats were grouped into 8 groups :1-Control group, 2-Irradiated group, groups 3,4,5 are irradiated with silymarin administration, irradiated with Vitamin E administration, irradiated with silymarin and Vitamin E administration groups respectively. The remaining three groups (6, 7, 8) served as healthy control with antioxidants administration. Paraffin sections stained with Hematoxylin and Eosin stain was used for showing microscopic changes. Following irradiation, the results showed dystrophic changes in the skin represented by atrophy of epidermal layers with absence of stratum corneum and epidermal vesicles formation. Collagen fibres were disorganized and appeared more eosinophilic and homogenous. Loss of skin appendages, lysis of collagen and edematous tissues were also observed in the dermal layer. Following administration of silymarin and Vitamin E the results showed improvement of the skin texture, while edema was still observed. conclusion: Treatment by silymarin alone or Vitamin E alone did not restore the damaging effect of electromagnetic radiation on rat skin. But when both antioxidants were given following radiation-exposure there were marked improvements on morphological structure of rat skin. These results indicate the importance of both silymarin and Vitamin E as protectors from the harmful effect of electromagnetic radiation on skin.

Direct determination of a radiation-damage profile with atomic resolution in ion-irradiated platinum. MSC report No. 5030

International Nuclear Information System (INIS)

Pramanik, D.; Seidman, D.N.

1983-05-01

The field-ion microscope (FIM) technique has been employed to determine directly a radiation damage profile, with atomic resolution, in a platinum specimen which had been irradiated at 80 0 K with 20-keV Kr + ions to a fluence of 5 x 10 12 cm - 2 . It is shown that the microscopic spatial-vacancy distribution (radiation-damage profile) is directly related to the elastically-deposited-energy profile. The experimentally constructed radiation-damage profile is compared with a theoretical damage profile - calculated employing the TRIM Monte Carlo code - and excellent agreement is obtained between the two, thus demonstrating that it is possible to go directly from a microscopic spatial distribution of vacancies to a continuous radiation-damage profile

Ionizing radiation target groups of band 3 inserted into egg lecithin liposomes as determined by Raman spectroscopy

International Nuclear Information System (INIS)

Verma, S.P.; Sonwalkar, N.

1993-01-01

The purified integral membrane protein, band 3, from human erythrocytes was inserted into egg lecithin liposomes. The insertion of band 3 was determined from thermal transition data from the analysis of the C-H stretching region bands recorded at temperatures from 25 to -22 o C. Raman spectra show that band 3 considerably broadens and lowers the thermal transition of egg lecithin liposomes, suggesting the insertion of band 3. The band 3-inserted liposomes were irradiated with gamma-rays (40 Gy) and the radiation target groups were determined by the analysis of the structural sensitive Raman bands in the 1600-1700 cm -1 (amide I), 1200-1300 cm -1 (amide III) and 550-1030 cm -1 (side chain amino groups) regions. The radiation-sensitive groups as identified from Raman spectra in the region 550-1030 cm -1 are tyrosines and cysteines. The radiation-induced changes in the secondary structure were determined from amide I and III bands. Quantitative estimation using the curve fitting method shows that ban 3 contains 44% total helix, 48% beta strand and 8% undefined plus turns (error + or - 4%). The secondary structure changes to 35% total helix, 42% total beta-strand and 23% turned and undefined upon irradiating band 3 containing liposomes. (Author)

A phase II randomized study of topical intrarectal administration of amifostine for the prevention of acute radiation-induced rectal toxicity

Energy Technology Data Exchange (ETDEWEB)

Kouloulias, V.E. [Dept. of Radiation Oncology, Aretaieion Univ. Hospital, Univ. of Athens Medical School, Athens (Greece); Dept. of Electrical and Computer Engineering, National Technical Univ. of Athens, Athens (Greece); Center of Radiation Oncology, YGEIA Diagnostic and Therapeutic Center of Athens, Athens (Greece); Kouvaris, J.R.; Kokakis, J.D.; Antypas, C.; Mallas, E.; Vosdoganis, S.P.; Vlahos, L.J. [Dept. of Radiation Oncology, Aretaieion Univ. Hospital, Univ. of Athens Medical School, Athens (Greece); Pissakas, G. [Radiotherapy Dept., Agios Savvas Anticancer Hospital, Athens (Greece); Matsopoulos, G. [Dept. of Electrical and Computer Engineering, National Technical Univ. of Athens, Athens (Greece); Michopoulos, S. [Gastroenterology Unit, Alexandra General Hospital, Athens (Greece); Kostakopoulos, A. [Urology Dept., Sismanoglio Hospital, Univ. of Athens Medical School, Athens (Greece)

2004-09-01

Purpose: to investigate the cytoprotective effect of intrarectal amifostine administration on acute radiation-induced rectal toxicity. Patients and methods: 67 patients with T1b-2 NO MO prostate cancer were randomized to receive amifostine intrarectally (group A, n - 33) or not (group B, n = 34) before irradiation. Therapy was delivered using a four-field technique with three-dimensional conformal planning. In group A, 1,500 mg amifostine was administered intrarectally as an aqueous solution in a 40-ml enema. Two different toxicity scales were used: EORTC/RTOG rectal and urologic toxicity criteria along with a Subjective-RectoSigmoid (S-RS) scale based on the endoscopic terminology of the World Organization for Digestive Endoscopy. Objective measurements with rectosigmoidoscopy were performed at baseline and 1-2 days after the completion of radiotherapy. The area under curve for the time course of mucositis (RTOG criteria) during irradiation represented the mucositis index (MI). Results: intrarectal amifostine was feasible and well tolerated without any systemic or local side effects. According to the RTOG toxicity scale, five out of 33 patients showed grade 1 mucositis in group A versus 15 out of 34 patients with grade 1/2 in group B (p = 0.026). Mean rectal MI was 0.3 {+-} 0.1 in group A versus 2.2 {+-} 0.4 in group B (p < 0.001), while S-RS score was 3.9 {+-} 0.5 in group A versus 6.3 {+-} 0.7 in group B (p < 0.001). The incidence of urinary toxicity was the same in both groups. Conclusion: intrarectal administration of amifostine seems to have a cytoprotective efficacy in acute radiation-induced rectal mucositis. Further randomized studies are needed for definitive therapeutic decisions. (orig.)

Radiation safety handbook for ionizing and nonionizing radiation

International Nuclear Information System (INIS)

Kincaid, C.B.

1976-10-01

The Handbook is directed primarily to users of radiation sources throughout the Food and Drug Administration. Specific precautions regarding the possession and use of radiation sources in meeting the Agency's objectives are an inherent responsibility of all employees. In addition, the increased emphasis on occupational safety and health and the responsibilities placed on the Department by Public Law and Executive Order make it mandatory that all organizational levels and activities conform to the intent of this Handbook. The policies and procedures described in this document apply to all Agency operators and activities and are intended to protect employees and the general public

Space Radiation Risk Assessment

Data.gov (United States)

National Aeronautics and Space Administration — Project A: Integration and Review: A review of current knowledge from space radiation physics was accepted for publication in Reviews of Modern Physics (Durante and...

Methylphenidate administration determines enduring changes in neuroglial network in rats.

Science.gov (United States)

Cavaliere, Carlo; Cirillo, Giovanni; Bianco, Maria Rosaria; Adriani, Walter; De Simone, Antonietta; Leo, Damiana; Perrone-Capano, Carla; Papa, Michele

2012-01-01

Repeated exposure to psychostimulant drugs induces complex molecular and structural modifications in discrete brain regions of the meso-cortico-limbic system. This structural remodeling is thought to underlie neurobehavioral adaptive responses. Administration to adolescent rats of methylphenidate (MPH), commonly used in attention deficit and hyperactivity disorder (ADHD), triggers alterations of reward-based behavior paralleled by persistent and plastic synaptic changes of neuronal and glial markers within key areas of the reward circuits. By immunohistochemistry, we observe a marked increase of glial fibrillary acidic protein (GFAP) and neuronal nitric oxide synthase (nNOS) expression and a down-regulation of glial glutamate transporter GLAST in dorso-lateral and ventro-medial striatum. Using electron microscopy, we find in the prefrontal cortex a significant reduction of the synaptic active zone length, paralleled by an increase of dendritic spines. We demonstrate that in limbic areas the MPH-induced reactive astrocytosis affects the glial glutamatergic uptake system that in turn could determine glutamate receptor sensitization. These processes could be sustained by NO production and synaptic rearrangement and contribute to MPH neuroglial induced rewiring. Copyright © 2011. Published by Elsevier B.V.

Foam-Reinforced Polymer Matrix Composite Radiation Shields, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — New and innovative lightweight radiation shielding materials are needed to protect humans in future manned exploration vehicles. Radiation shielding materials are...

Optimization of Fluosol-DA administration during a fractionated radiation protocol in the Lewis lung carcinoma

International Nuclear Information System (INIS)

Teicher, B.A.; McIntosh, N.L.

1987-01-01

The perfluorchemical emulsion, Fluosol-DA, in combination with breathing a 100% or 95% oxygen atmosphere, has been shown to enhance the response of several solid rodent tumors to single dose and fractionated radiation treatment. As an approach to determining the optimal dose schedule for Fluosol-DA during a course of fractionated radiation therapy, a total dose of 16 ml/kg of Fluosol-DA was administered either as two doses of 8 ml/kg on days 1 and 3 or as four doses of 4 ml/kg on days 1,2,3 and 4 of a four day protocol using the Lewis lung tumor model system. The Lewis lung tumor was grown s.c. in the flanks of C57BL/6J mice. Treatment was initiated when the tumors were 50-100 mm/sup 3/. Radiation was delivered as 4 daily fractions of 2.5, 4.0 or 5.0 Gray. Fluosol-DA was adminstered i.v. prior to irradiation. Each day carbogen breathing was maintained for 1 hr prior to and during each x-ray treatment. When Fluosol-DA was administered as two doses of 8 ml/kg, the dose modifying factor (DMF) observed was 1.7 +- 0.3. When Fluosol-DA was given as four doses of 4 ml/kg, the DMF was 1.5+-0.3 compared to x-ray treatment with carbogen breathing. It appears, therefore, administering Fluosol-DA at a therapeutic dose less frequently with carbogen breathing with every fraction may produce a better treatment outcome than giving more frequent lower doses

Radiation signatures

International Nuclear Information System (INIS)

McGlynn, S.P.; Varma, M.N.

1992-01-01

A new concept for modelling radiation risk is proposed. This concept is based on the proposal that the spectrum of molecular lesions, which we dub ''the radiation signature'', can be used to identify the quality of the causal radiation. If the proposal concerning radiation signatures can be established then, in principle, both prospective and retrospective risk determination can be assessed on an individual basis. A major goal of biophysical modelling is to relate physical events such as ionization, excitation, etc. to the production of radiation carcinogenesis. A description of the physical events is provided by track structure. The track structure is determined by radiation quality, and it can be considered to be the ''physical signature'' of the radiation. Unfortunately, the uniqueness characteristics of this signature are dissipated in biological systems in ∼10 -9 s. Nonetheless, it is our contention that this physical disturbance of the biological system eventuates later, at ∼10 0 s, in molecular lesion spectra which also characterize the causal radiation. (author)

Determining composition of a substance by the use of both reflected and transmitted radiation

International Nuclear Information System (INIS)

Teller, S.

1975-01-01

An apparatus for the determination of the content of sulfur in hydrocarbon fuels comprising a primary and a secondary source of γ- or x-rays arranged on opposite sides of a test zone and a detector connected to a recording device for detecting and recording backscattered and transmitted rays emitted by the radiation sources is described

Results of the Association of Directors of Radiation Oncology Programs (ADROP) Survey of Radiation Oncology Residency Program Directors

International Nuclear Information System (INIS)

Harris, Eleanor; Abdel-Wahab, May; Spangler, Ann E.; Lawton, Colleen A.; Amdur, Robert J.

2009-01-01

Purpose: To survey the radiation oncology residency program directors on the topics of departmental and institutional support systems, residency program structure, Accreditation Council for Graduate Medical Education (ACGME) requirements, and challenges as program director. Methods: A survey was developed and distributed by the leadership of the Association of Directors of Radiation Oncology Programs to all radiation oncology program directors. Summary statistics, medians, and ranges were collated from responses. Results: Radiation oncology program directors had implemented all current required aspects of the ACGME Outcome Project into their training curriculum. Didactic curricula were similar across programs nationally, but research requirements and resources varied widely. Program directors responded that implementation of the ACGME Outcome Project and the external review process were among their greatest challenges. Protected time was the top priority for program directors. Conclusions: The Association of Directors of Radiation Oncology Programs recommends that all radiation oncology program directors have protected time and an administrative stipend to support their important administrative and educational role. Departments and institutions should provide adequate and equitable resources to the program directors and residents to meet increasingly demanding training program requirements.

Resistive Memory Devices for Radiation Resistant Non-Volatile Memory

Data.gov (United States)

National Aeronautics and Space Administration — Ionizing radiation in space can damage electronic equipment, corrupting data and even disabling computers. Radiation resistant (rad hard) strategies must be employed...

Trends in use of non-medical radiation sources in Slovenia

International Nuclear Information System (INIS)

Giacomelli, M.; Cesarek, J.; Osojnik, I.

2007-01-01

Slovenian Nuclear Safety Administration is the regulatory authority competent also for administrative control in the fields of radiation practices and use of radiation sources in industry and research, with exception in medicine and veterinary medicine. Prior to the adoption of the Act on Protection against Ionizing Radiation and Nuclear Safety the responsible authority was the Health Inspectorate of Republic of Slovenia. The article presents an overview of the use of radiation sources in Slovenia, in industry, research and education. Analysis of the data from abovementioned regulators shall examine trends in use in recent years as number of sources and organizations, and according to the type of their intended use. (author)

Caffeine ameliorates radiation-induced skin reactions in mice but does not influence tumour radiation response

Energy Technology Data Exchange (ETDEWEB)

Hebbar, S.A.; Mitra, A.K.; George, K.C.; Verma, N.C. [Radiation Biology Division, Bhabha Atomic Research Centre, Trombay, Mumbai (India)]. E-mail: ncverma@apsara.barc.ernet.in

2002-03-01

Intramuscular administration of caffeine at a dose of 80 mg kg{sup -1} body weight to the gastrocnemius muscles of Swiss mice 5 min prior to local irradiation (35 Gy) of the leg delayed the progression of radiation-induced skin reactions in such animals. While 90% epilation with reddening of the skin was noted in animals treated with radiation alone, animals pretreated with caffeine suffered only partial hair loss with slight reddening of the skin on the 16th and 20th days post-irradiation. Beyond the 28th day, damage scores in irradiated feet for both the groups were similar (score 3) and remained unchanged until the 32nd day and then decreased and disappeared completely in both treatment groups by the 40th day after irradiation. In addition, the effect of caffeine on the radiation response of a mouse fibrosarcoma was investigated. Results showed that intratumoral administration of caffeine at a dose of 80 mg kg{sup -1} body weight 5 min prior to local exposure of tumours to 10 Gy of {sup 60}Co {gamma}-rays did not influence the response of tumours to radiation. The present study thus showed that although caffeine ameliorated radiation-induced skin reactions in the mouse leg, it did not affect the tumour radiation response, indicating its potential application in cancer radiotherapy. (author)

Radiation dose determines the method for quantification of DNA double strand breaks

International Nuclear Information System (INIS)

Bulat, Tanja; Keta, Olitija; Korićanac, Lela; Žakula, Jelena; Petrović, Ivan; Ristić-Fira, Aleksandra; Todorović, Danijela

2016-01-01

Ionizing radiation induces DNA double strand breaks (DSBs) that trigger phosphorylation of the histone protein H2AX (γH2AX). Immunofluorescent staining visualizes formation of γH2AX foci, allowing their quantification. This method, as opposed to Western blot assay and Flow cytometry, provides more accurate analysis, by showing exact position and intensity of fluorescent signal in each single cell. In practice there are problems in quantification of γH2AX. This paper is based on two issues: the determination of which technique should be applied concerning the radiation dose, and how to analyze fluorescent microscopy images obtained by different microscopes. HTB140 melanoma cells were exposed to γ-rays, in the dose range from 1 to 16 Gy. Radiation effects on the DNA level were analyzed at different time intervals after irradiation by Western blot analysis and immunofluorescence microscopy. Immunochemically stained cells were visualized with two types of microscopes: AxioVision (Zeiss, Germany) microscope, comprising an ApoTome software, and AxioImagerA1 microscope (Zeiss, Germany). Obtained results show that the level of γH2AX is time and dose dependent. Immunofluorescence microscopy provided better detection of DSBs for lower irradiation doses, while Western blot analysis was more reliable for higher irradiation doses. AxioVision microscope containing ApoTome software was more suitable for the detection of γH2AX foci. (author)

Radiation dose determines the method for quantification of DNA double strand breaks

Energy Technology Data Exchange (ETDEWEB)

Bulat, Tanja; Keta, Olitija; Korićanac, Lela; Žakula, Jelena; Petrović, Ivan; Ristić-Fira, Aleksandra [University of Belgrade, Vinča Institute of Nuclear Sciences, Belgrade (Serbia); Todorović, Danijela, E-mail: dtodorovic@medf.kg.ac.rs [University of Kragujevac, Faculty of Medical Sciences, Kragujevac (Serbia)

2016-03-15

Ionizing radiation induces DNA double strand breaks (DSBs) that trigger phosphorylation of the histone protein H2AX (γH2AX). Immunofluorescent staining visualizes formation of γH2AX foci, allowing their quantification. This method, as opposed to Western blot assay and Flow cytometry, provides more accurate analysis, by showing exact position and intensity of fluorescent signal in each single cell. In practice there are problems in quantification of γH2AX. This paper is based on two issues: the determination of which technique should be applied concerning the radiation dose, and how to analyze fluorescent microscopy images obtained by different microscopes. HTB140 melanoma cells were exposed to γ-rays, in the dose range from 1 to 16 Gy. Radiation effects on the DNA level were analyzed at different time intervals after irradiation by Western blot analysis and immunofluorescence microscopy. Immunochemically stained cells were visualized with two types of microscopes: AxioVision (Zeiss, Germany) microscope, comprising an ApoTome software, and AxioImagerA1 microscope (Zeiss, Germany). Obtained results show that the level of γH2AX is time and dose dependent. Immunofluorescence microscopy provided better detection of DSBs for lower irradiation doses, while Western blot analysis was more reliable for higher irradiation doses. AxioVision microscope containing ApoTome software was more suitable for the detection of γH2AX foci. (author)

Radiation legacy of nuclear tests at the Semipalatinsk test site in the light of requirements ensuring radiation safety performance

International Nuclear Information System (INIS)

Logachev, V.A.; Logacheva, L.A.

2005-01-01

Peculiarities of nuclear tests radiation legacy at the Semipalatinsk test site (STS) are shown in the light of performance of requirements ensuring radiation safety, decrease radiation contamination levels in environment and minimize exposure of radiation for population residing contaminated areas by radioactive fallout. The paper provides data on characterization of peculiarities of the STS operation legacy based on review of archival data of the former 3-d General Administration under USSR Ministry of Health. (author)

Determination of Several Clinical Parameters of the Blood for the HealthyEvaluation of the Radiation Worker

International Nuclear Information System (INIS)

Yazid, M; Triyono; Aris-Bastianudin

2000-01-01

Determination of the several clinical parameters of the blood for healthyevaluation of the radiation worker has been done. This research was done forarrangement of the medical general check up of the radiation worker toobserve pathological indicator of several body organs. The blood sample wastaken from vena mediana cubiti and analyzed by reagent using standardprocedure from Boehringer Mainheim. That procedure is specific for eachclinical parameters. That clinical parameters concentration was measured byClinicon Photometer 4010. The clinical data of the radiation worker wascompared to the non radiation worker. The measurement results of 501patients, shown that total protein concentrations for all worker are > 8.00g%, the cholesterol concentration of 25 patient are > 260 mg%. The glucoseconcentration for fasting condition of 7 patients are > 200 mg/dl, the ureumconcentration of all patients are 7mg% and the creatinine of 112 patients are > 1.4 mg%. From those results canbe concluded that the most pathological indicator can be identified fromliver, heart and kidney function respectively. From the clinical aspects canbe seen that there is no significant difference between the health ofradiation worker and non radiation worker. (author)

Radiation sterilisation dose determination for lyophilised amnion membranes and lyophilised bone grafts

International Nuclear Information System (INIS)

Hilmy, N.; Basril, A.; Febrida, A.

1999-01-01

Radiation sterilisation of medical products is now well established in commercial scale and at present there are more than two hundred irradiation facilities in operation throughout the world. It is a cold sterilisation process without toxic chemical residues, high degree of safety and easy to control, so that it is a safe technology to sterilise human tissue grafts. According to ISO (International Organisation of Standard) No. 11137, radiation sterilisation dose should be established based on the number of product's bioburden (number of product's contaminated microbes before irradiation). Bioburden of lyophilised amnion membranes and lyophilised bone grafts produced by Batan Research Tissue Bank (BRTB) have been determined since 1990 and 1994 consecutively by using 100 up to 120 pieces of samples per year. Results show that the average bioburden of the amnion membranes were 1.4 ( 0.2 x 103; 1.2 (0.2 x 103; 1.2 ( 1.2 x 103; 4.5 ( 0.5 x 102; 1.8 ( 0.9 x 102; 2.4 ( 2.3 x 102; 1.7(l.5 x 102; 1.5 ( 1.7 x 102 cells per sample, calculated in 1990 to 1997 consecutively and the average bioburden of the bonegrafts were 1.5 (0.4x 101; 0.25 (0.12 x 101; 0; 0 cells per sample, calculated in 1994 to 1997 consecutively. Morphological of those contaminants were found to be Gram positive coccoid forms (98%) and Gram positive vegetative rod (2%) with the D10 - values of 0.25 to 0.50 kGy. No spore forming bacteria and Gram negative bacteria were found in those contaminations. The highest bioburden of lyophilised amnion membranes and lyophilised bone grafts were found to be 4900 and 80 cells per sample consecutively, and the lowest was found to be 0 cell per sample in both of materials observed. According to ISO 11137 radiation sterilisation doses for amnion membranes were ranging between 21 to 25 kGy and for bone grafts was around 15 kGy with the Sterility Assurance Level (SAL) of 106. Since 1990, radiation sterilisation dose used for lyophilised amnion membranes produced by BRTB

Biological dosimetry to determine the UV radiation climate inside the MIR station and its role in vitamin D biosynthesis

Science.gov (United States)

Rettberg, P.; Horneck, G.; Zittermann, A.; Heer, M.

1998-11-01

The vitamin D synthesis in the human skin, is absolutely dependent on UVB radiation. Natural UVB from sunlight is normally absent in the closed environment of a space station like MIR. Therefore it was necessary to investigate the UV radiation climate inside the station resulting from different lamps as well as from occasional solar irradiation behind a UV-transparent quartz window. Biofilms, biologically weighting and integrating UV dosimeters successfully applied on Earth (e.g. in Antarctica) and in space (D-2, Biopan I) were used to determine the biological effectiveness of the UV radiation climate at different locations in the space station. Biofilms were also used to determine the personal UV dose of an individual cosmonaut. These UV data were correlated with the concentration of vitamin D in the cosmonaut's blood and the dietary vitamin D intake. The results showed that the UV radiation climate inside the Mir station is not sufficient for an adequate supply of vitamin D, which should therefore be secured either by vitamin D supplementat and/or by the regular exposure to special UV lamps like those in sun-beds. The use of natural solar UV radiation through the quartz window for `sunbathing' is dangerous and should be avoided even for short exposure periods.

Efficacy of polysaccharide from Alcaligenes xylosoxidans MSA3 administration as protection against γ-radiation in female rats

International Nuclear Information System (INIS)

Hassan, Amal I.; Ghoneim, Mona A. M.; Mahmoud, Manal G.; Asker, Mohsen M. S.; Mohamed, Saher S.

2016-01-01

Damage to normal tissues is a consequence of both therapeutic and accidental exposures to ionizing radiation. A water-soluble heteropolysaccharide called AXEPS, composed of glucose, galactose, rhamnose and glucouronic acid in a molar ratio of nearly 1.0:1.6:0.4:2.3, respectively, was isolated from culture medium of strain Alcaligenes xylosoxidans MSA3 by ethanol precipitation followed by freeze-drying. Chemical analysis, Fourier-transform infrared (FTIR) and chromatographic studies revealed that the molecular weight was 1.6 × 10 4 g mol −1 . This study was designed to investigate the radioprotective and biological effects of AXEPS in alleviating the toxicity of ionizing radiation in female albino rats. A total of 32 female albino rats were divided into four groups. In the control group, rats were administered vehicle by tube for four weeks. The second group was administered AXEPS (100 mg/kg) orally by gavage for four weeks. Animals in the third group were exposed to whole-body γ-rays (5 Gy) and remained for 2 weeks without treatment. The fourth group received AXEPS (100 mg/kg) orally by gavage for two weeks before being exposed to whole-body γ-rays (5 Gy), then 24 h post γ-rays, they received AXEPS (100 mg/kg) in a treatment continuing till the end of the experiment (15 days after the whole–body γ-irradiation). Oral administration of AXEPS (100 mg/kg) significantly reversed the oxidative stress effects of radiation, as evidenced by the decrease in DNA damage in the bone marrow. Assessment of apoptosis and cell proliferation markers revealed that caspase-3 significantly increased in the irradiated group. Moreover, a significant decrease in the hematological constituents of peripheral blood, the chemotactic index and CD8+ T cells were observed in animals in the irradiation-only group, whereas an increase in the lymphocyte index was observed in animals in that group. In contrast, AXEPS treatment prevented these alterations. From our results, we conclude that

Factors determining radiation-induced mixing at interfaces

International Nuclear Information System (INIS)

Collins, R.

1986-01-01

A review is given of the principal mechanisms contributing to atomic mixing produced by ion beams at initially well-defined interfaces between solid phases. Their relative importance is discussed in the light of available experimental evidence, and a critical survey is given of current mathematical models. The case of a thin interior implant layer is included. Those aspects of surface sputtering of direct relevance to the construction of the mixing equations are examined. Mixing mechanisms considered are ballistic relocation, diffusion, radiation-induced segregation, and drifts induced by chemical affinities of the elements concerned, together with constraints on all these from packing (Kirkendall) effects. Ballistic terms are subdivided into direct-recoil and cascade contributions. A brief review is given of the established methods of modelling them by using relocation integral cross-sections, and also the limitations and advantages of their approximation by differential equations of Fokker-Planck (diffusion) type. Genuinely diffusive mechanisms involved are thermal and radiation-enhanced diffusion; the question of the most appropriate form of Fick's law to use in each case is considered. The packing effects may be modelled either as a lattice relaxation to be imposed following each radiation dose increment, or as a continuously computed reversed collective current of atoms. These two approaches are discussed. (author)

Iodine 131 therapy patients: radiation dose to staff

International Nuclear Information System (INIS)

Castronovo, F.P. Jr.; Beh, R.A.; Veilleux, N.M.

1986-01-01

Metastasis to the skeletal system from follicular thyroid carcinoma may be treated with an oral dose of 131 I-NaI. Radiation exposures to hospital personnel attending these patients were calculated as a function of administered dose, distance from the patient and time after administration. Routine or emergency patient handling tasks would not exceed occupational radiation protection guidelines for up to 30 min immediately after administration. The emergency handling of several patients presents the potential for exceeding these guidelines. (author)

Who is protecting us against the radiation protectors?

International Nuclear Information System (INIS)

Lorenz, Bernd

2018-01-01

The ICRU proposal of new radiation dose units is discusses with respect to the consequences for radiation protection in practice. For the range of 70 keV to 10 MeV gamma radiation practically no differences are obvious. The disadvantages include an increase of administrative procedures, retrofitting of measuring devices including personal dosimeters and software.

Hematopoietic Acute Radiation Syndrome (Bone marrow syndrome, Aplastic Anemia): Molecular Mechanisms of Radiation Toxicity.

Science.gov (United States)

Popov, Dmitri

found in the umbilical cord and bone marrow as hematopoietic cells, a subset of mesenchymal stem cells, endothelial progenitor cells, endothelial cells of blood vessels, etc. [Beutler et al. 2000 ] Potential mechanisms responsible for radiation-acquired marrow cell failure include direct toxicity , direct damage of hematopoietic multipotential cells or cellular or humoral immune suppression of the marrow multipotential cells. [ Beutler et al. 2000] Methods: These studies were conducted at several different research institutions and laboratories listed as follows: Kazan All-Union Scientific Research Veterinary, Biotechnology Centre of Russian Academy of Science (North Osetia), Institute Belarussian Scientific and Research Institute for Radiobiology in Gomel, the St. Petersburg Veterinary Institute, the Advanced Medical Technology and Systems Inc., Ontario, Canada. The studies were approved by the Animal Care and Use Committee for ethical animal research equivalent, at each institution. A critically important volume of purified Radiation Toxins (RT) was isolated from larger mammalian irradiated animals. Subsequently the RT were characterized chemically and biologically. The experimental design of later studies compared relative toxicity, potential for development of acute radiation hematopoietic syndrome, and potential cloning disorder of multipotential hematopoietic progenitors and their derivative and lethality after intravenous or intramuscular injections of SRD containing Hematopoietic Radiation Toxins. These experiments have employed a wide variety of experimental animals. The animals were irradiated in RUM-17, Puma, and Panorama devices. The dose varied from 0.7Gy to 100Gy. The methods of immune depletion, immuno-lympho plasmasabsorption, as well as direct extraction, were used to refine and purify the specific Radiation Toxins from the central lymph of animals with Hematopoietic forms of Radiation Toxins. Experiments include administration of Hematopoietic

ENTRIA workshop. Determine threshold values in radiation protection

International Nuclear Information System (INIS)

Diener, Lisa

2015-01-01

Threshold values affect our daily lives. Whether it concerns traffic or noise regulations, we all experience thresholds on a regular basis. But how are such values generated? The conference ''Determine Thres-hold Values in Radiation Protection'', taking place on January 27th 2015 in Braunschweig, focused on this question. The conference was undertaken in the context of the BMBF-funded interdisciplinary research project ''ENTRIA - Disposal Options for Radioactive Residues''. It aimed to stimulate a cross-disciplinary discussion. Spea-kers from different disciplinary backgrounds talked about topics like procedures of setting threshold values, standards for evaluating dosages, and public participation in the standardization of threshold values. Two major theses emerged: First, setting threshold values always requires considering contexts and protection targets. Second, existing uncertainties must be communicated in and with the public. Altogether, the conference offered lots of input and issues for discussion. In addition, it raised interesting and important questions for further and ongoing work in the research project ENTRIA.

High Temperature Radiators for Electric Propulsion Systems, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — The VASIMR propulsion system uses a high temperature Loop Heat Pipe (LHP) radiator to reject heat from the helicon section. The current baseline radiator uses...

Developing a training programme for radiation protection officers at industrial irradiators

International Nuclear Information System (INIS)

Davor, P.

2013-04-01

A training programme for staff of irradiation facilities especially radiation safety officers at industrial irradiation facilities has been developed. The programme focused on technical and administrative basis for ensuring radiation safety at the practices. It consists of thirteen modules ranging from fundamentals of radiation, biological effects of ionizing radiation as well as the technical and administrative issues pertinent to radiation safety of the sources. The overall objective of this programme was to build competence in the area of radiation protection and raise the confidence level of staff of industrial irradiation facilities. The modules are structured in a manner that attempts to give a good understanding to participants on safety features of irradiators and use of radiation monitoring equipment. Each module has specific objectives and expected outcome and the course content is also stated under each module. The duration of the whole programme is sixteen weeks and the participants are expected to have some working knowledge in radiation protection and safe use of radiation sources. (au)

Nevada Test Site Radiation Protection Program

Energy Technology Data Exchange (ETDEWEB)

Radiological Control Managers' Council, Nevada Test Site

2007-08-09

Title 10 Code of Federal Regulations (CFR) 835, 'Occupational Radiation Protection', establishes radiation protection standards, limits, and program requirements for protecting individuals from ionizing radiation resulting from the conduct of U.S. Department of Energy (DOE) activities. 10 CFR 835.101(a) mandates that DOE activities be conducted in compliance with a documented Radiation Protection Program (RPP) as approved by DOE. This document promulgates the RPP for the Nevada Test Site (NTS), related (onsite or offsite) DOE National Nuclear Security Administration Nevada Site Office (NNSA/NSO) operations, and environmental restoration offsite projects.

The safety of radiation sources and radioactive materials in China

International Nuclear Information System (INIS)

Liu, H.

2001-01-01

The report describes the present infrastructure for the safety of radiation sources in China, where applications of radiation sources have become more and more widespread in the past years. In particular, it refers to the main functions of the National Nuclear Safety Administration of the State Environmental Protection Administration (SEPA), which is acting as the regulatory body for nuclear and radiation safety at nuclear installations, the Ministry of Public Health which issues licences for the use of radiation sources, and the Ministry of Public Security, which deals with the security of radiation sources. The report also refers to the main requirements of the existing regulatory system for radiation safety, i.e. the basic dose limits for radiation workers and the public, the licensing system for nuclear installations and for radioisotope-based and other irradiation devices, and the environmental impact assessment system. Information on the nationwide survey of radiation sources carried out by SEPA in 1991 is provided, and on some accidents that occurred in China due to loss of control of radiation sources and errors in the operation of irradiation facilities. (author)

Research Laboratory of Mixed Radiation Dosimetry

International Nuclear Information System (INIS)

2002-01-01

determined as a product H = D·Q of the absorbed dose, D, and radiation quality factor, Q, both determined by the recombination chamber. The chambers can be used for determination of dose equivalents of any external radiation, therefore also in neutron and neutron-gamma fields. REFERENCE NEUTRON FIELDS Standard neutron fields, traceable to primary standard laboratory (NPL, Great Britain) were established at the Institute of Atomic Energy almost ten years ago. The fields are formed by calibrated sources of 252 Cf and 241 Am-Be. Additionally, spherical filters made of iron or paraffin can be used for modification of the neutron spectrum and gamma component of absorbed dose. The fields are used mostly for research work but they also serve as only one in Poland facility suitable for calibration of neutron dose meters used in radiation protection. Maintenance of the fields includes some periodic measurements of the dosimetric parameters, improvements of the measuring methods and international intercomparisons. RESEARCH ON INTERNAL DOSIMETRY - Two research projects were carried out in 2001-evaluation of the data on intake of radiocesium after the Chernobyl accident and research on calibration of thyroid counter with regard to depth of thyroid gland. The second of the projects can be applied not only for radiation protection but also for improvement of measurements of iodine uptake in thyroid after diagnostic administration of 131 I. (author)

The determination of the penetrating radiation dose at Hanford

International Nuclear Information System (INIS)

Rathbun, L.A.

1989-09-01

Most of the thermoluminescent dosimeters (TLDs) and other devices that have been used to measure environmental radiation on the Hanford Site have measured natural background levels of radiation. Measurements of offsite environmental radiation near the boundary of the Hanford Site have often indicated higher doses than onsite measurements have. However, the converse has been found when radiation measurements from the cities and communities of southeastern Washington were compared with onsite measurements. The historical trends described for environmental TLD data have been better defined in this study by compiling the TLD data for selected locations over a 6-year period (1983 to 1988). The ongoing Hanford Environmental Surveillance Program also provides radionuclide concentrations in soil based on samples collected by technicians at Pacific Northwest Laboratory (PNL) and sent to a commercial laboratory for analyses. As part of the study described in this report, a portable gamma spectroscopy system was used in the field to identify concentrations of gamma-emitting radionuclides in the soil at various locations on the Hanford Site and in the surrounding area. This work began in 1986. Supplemental radiation measurements were made with a microprocessor-based survey meter and large NaI detector. 20 refs., 4 figs., 3 tabs

Adriamycin-radiation combinations: drug induced delayed gastrointestinal radiosensitivity

International Nuclear Information System (INIS)

Schenken, L.L.; Burholt, D.R.; Kovacs, C.J.

1979-01-01

The administration of Adriamycin (ADR) results in acute short-term reductions in cell production within the gastrointestinal mucosa. Interactions between ADR doses and radiation appear minimized as the inter-treatment time interval expands to five days. However, as the times between drug administration and abdominal radiation exposure are further lengthened (from 14 to 49 days), a progressively severe defect in post-irradiation mucosal cell production is noted. Although the mucosa appears abnormal histologically and crypt cell cellularity and cell production are normal, the proliferative response following radiation is reduced by as much as 50% if ADR is given 7 weeks prior to the radiation exposure. We postulate that this effect is a manifestation of latent damage to the stem cell compartment within the crypt or that secondary support systems such as mucosal vascularity have been compromised by ADR

Maximizing therapeutic gain with gemcitabine and fractionated radiation

International Nuclear Information System (INIS)

Mason, Kathy A.; Milas, Luka; Hunter, Nancy R.; Elshaikh, Mohamed; Buchmiller, Lara; Kishi, Kazushi; Hittelman, K. Walter; Ang, K. Kian

1999-01-01

Purpose/Objective: The nucleoside analogue gemcitabine inhibits cellular repair and repopulation, induces apoptosis, causes tumor growth delay, and enhances radiation-induced growth delay. After single doses of drug and radiation, maximum enhancement of tumor response was obtained when gemcitabine preceded radiation by at least 24 h. Conversely, the cellular radioresponse of the normal gastrointestinal epithelium was slightly protected when gemcitabine and radiation were separated by 24 h. This differential response created a time frame within which therapeutic gain could be maximized. In our present investigation, we sought to define the most therapeutically beneficial scheme of gemcitabine administration when combined with fractionated radiotherapy. Methods and Materials: C3Hf/Kam mice were given identical drug and radiation schedules of administration, and both normal tissue (jejunal mucosa) and tumor (Sa-NH) responses were measured. Irradiation was given once per day for 5 days in normal tissue and tumor growth delay studies and twice per day for the tumor cure endpoint. A total dose of 25 mg/kg gemcitabine was given i.p. in 1 of 3 schedules: a single dose of 25 mg/kg 24 h before the start of fractionated irradiation, 12.5 mg/kg 24 h before the first and third radiation doses, or 24 h before each of 5 radiation doses. Groups of mice bearing 7- or 8-mm diameter tumors were treated with gemcitabine alone or in combination with fractionated irradiation under ambient or hypoxic conditions. The survival response of the jejunal mucosa was quantified by the microcolony assay and histologically by quantifying apoptosis, mitosis, S-phase fraction, and crypt cellularity. Results: For tumor growth delay, dose-modifying factors (DMFs) were similar (1.34-1.46) for all 3 schedules of drug administration. In contrast, the response of the jejunum was strongly dependent on the schedule of gemcitabine administration. A single dose of gemcitabine before the start of fractionated

Applicability of discovery science approach to determine biological effects of mobile phone radiation.

Science.gov (United States)

Leszczynski, Dariusz; Nylund, Reetta; Joenväärä, Sakari; Reivinen, Jukka

2004-02-01

We argue that the use of high-throughput screening techniques, although expensive and laborious, is justified and necessary in studies that examine biological effects of mobile phone radiation. The "case of hsp27 protein" presented here suggests that even proteins with only modestly altered (by exposure to mobile phone radiation) expression and activity might have an impact on cell physiology. However, this short communication does not attempt to present the full scientific evidence that is far too large to be presented in a single article and that is being prepared for publication in three separate research articles. Examples of the experimental evidence presented here were designed to show the flow of experimental process demonstrating that the use of high-throughput screening techniques might help in rapid identification of the responding proteins. This, in turn, can help in speeding up of the process of determining whether these changes might affect human health.*

Iodine capsules in thyroid therapy: An individually controlled study of I-131 uptake kinetics as compared to liquid administration

International Nuclear Information System (INIS)

von Schulthess, G.K.; Seelentag, W.W.; Pfeiffer, G.; Blauenstein, P.; Bekier, A.

1984-01-01

The aim of this study was to determine the additional radiation dose sustained by parts of the patients gastric mucosa when given I-131 therapy in capsular rather than liquid form, and thus to establish the safety of this procedure. 16 patients with benign thyroid disease were studied by measuring serum radioactivity at 0, 5, 10, 20, 40, and 80 min. after administration of the capsule (120-200 MBq I131). These serum uptake values were compared to the uptake after administration of a liquid diagnostic dose of I-131 (2 MBq). From the resulting uptake curves the delay due to capsular dissolution was determined. The average dissolution time was found to be 12 min. with a large standard deviation of 7 min. Also, a theoretical curve was computed to indicate the dose rate as a function of the distance from the surface of the capsule. Based on this information the maximum dose to the gastric mucosa is of the order of 250 cGy for a therapeutic activity of 185 MBq, which is the maximum dose which may be given as single application to outpatients in Switzerland. By having the patient swallow some liquid during the first ten minutes, the capsule can be made to move around, and hence, the local radiation dose can be reduced substantially. The authors conclude, that I-131 in capsular form is a safe galenic form for therapeutic use in patients with thyroid disease. When large doses are given, administration of the dose in several capsules may be advisable

Determination of incoming solar radiation in major tree species in Turkey.

Science.gov (United States)

Yilmaz, Osman Yalcin; Sevgi, Orhan; Koc, Ayhan

2012-07-01

Light requirements and spatial distribution of major forest tree species in Turkey hasn't been analyzed yet. Continuous surface solar radiation data, especially at mountainous-forested areas, are needed to put forward this relationship between forest tree species and solar radiation. To achieve this, GIS-based modeling of solar radiation is one of the methods used in rangelands to estimate continuous surface solar radiation. Therefore, mean monthly and annual total global solar radiation maps of whole Turkey were computed spatially using GRASS GIS software "r.sun" model under clear-sky (cloudless) conditions. 147498 pure forest stand point-based data were used in the study for calculating mean global solar radiation values of all the major forest tree species of Turkey. Beech had the lowest annual mean total global solar radiation value of 1654.87 kWh m(-2), whereas juniper had the highest value of 1928.89 kWh m(-2). The rank order of tree species according to the mean monthly and annual total global solar radiation values, using a confidence level of p solar radiation values of sites and light requirements of forest trees ranked similarly.

Active Radiation Shield, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — DEC-Shield technology offers the means to generate electric power from cosmic radiation sources and fuse dissimilar systems and functionality into a structural...

Natural radiation, radioactive waste and chemical risk determinants

International Nuclear Information System (INIS)

Christensen, T.; Mustonen, R.; Edhwall, H.; Hansen, H.; Soerensen, A.; Stranden, E.

1990-01-01

Doses from natural radiation to the population in the Nordic countries are summarized, and man-made modifications of the natural radiation environment are discussed. An account is given for the radiological concequences of energy concervation by reduced ventilation. Risks from possible future releases of radioactivity from final depositories of spent nuclear fuel are compared to the risks from present natural radioactivity in the environment. The possibilities for comparison between chemical and radiological risks are discussed. 104 refs., 36 figs., 47 tabs

Determination of intake and internal radiation dose for occupationally exposed workers to iodine 131

International Nuclear Information System (INIS)

Kharita, M. H.; Maghrabi, M.; Sadyya, A.

2004-12-01

Workers who prepare and inject radioactive Iodine I 131 doses at the medical centers in Syria are potentially exposed to the radioactive intake by ingestion or inhalation during preparation or injection processes. The received amount of the radioactive intake differs according to the amount of the I 131 that released during the preparation or injection processes, and to the work conditions and the applying ways of the radiation protection principles. Because of this radioactive intake, the thyroid gland may expose to amounts of I 131 which may negatively affect the health of the workers, so it is necessary to make routine monitoring for all workers who receive an intake of more than 10% of the annual intake limit which is (2*10 6 Bq/y) for I 131 . To make this monitoring process, it is necessary to use either the thyroid gland counter in order to know the concentrated amount of the radioactivity in the gland, or the analysis of a 24 hours urine sample of the exposed workers to determine the eliminated amount of the radioactivity using gamma spectrometry, also the two processes can be applied at the same time. Since the thyroid gland counter is not available, the analysis of urine sample was done to determine the concentrated amount of the radioactivity in urine, then to estimate the radioactive intake and the internal radioactive dose. The results of applying this method dictated that some workers work in safe conditions according to the radiation protection and there is no need for them to make routine monitoring . But the other workers receive a radioactive intake of about 10% yearly of the annual intake limit and that requires a routine periodical monitoring for those workers in addition to the necessity of applying the principles of the radiation protection during the work with I 131 . These principles and systems should indicate the basic requirement of radiation protection that must be available in the laboratory that deal with I 131 either for therapy or for

Medical Management of Acute Radiation Syndromes : Comparison of Antiradiation Vaccine and Antioxidants radioprotection potency.

Science.gov (United States)

Maliev, Slava; Popov, Dmitri; Lisenkov, Nikolai

Introduction: This experimental study of biological effects of the Antiradiation Vaccine and Antioxidants which were used for prophylaxis and treatment of the Acute Radiation Syndromes caused by high doses of the low-LET radiation. An important role of Reactive Oxyden Species (Singlet oxygen, hydroxyl radicals, superoxide anions and bio-radicals)in development of the Acute Radiation Syndromes could be defined as a "central dogma" of radiobiology. Oxida-tion and damages of lipids, proteins, DNA, and RNA are playing active role in development of postradiation apoptosis. However, the therapeutic role of antioxidants in modification of a postradiation injury caused by high doses of radiation remains controversial.Previous stud-ies had revealed that antioxidants did not increase a survival rate of mammals with severe forms of the Acute Radiation Syndromes caused by High Doses of the low-LET radiation. The Antiradiation Vaccine(ARV) contains toxoid forms of the Radiation Toxins(RT) from the Specific Radiation Determinants Group (SRD). The RT SRD has toxic and antigenic prop-erties at the same time and stimulates a specific antibody elaboration and humoral response form activated acquired immune system. The blocking antiradiation antibodies induce an im-munologically specific effect and have inhibiting effects on radiation induced neuro-toxicity, vascular-toxicity, gastrointestinal toxcity, hematopoietic toxicity, and radiation induced cytol-ysis of selected groups of cells that are sensitive to radiation. Methods and materials: Scheme of experiments: 1. Irradiated animals with development of Cerebrovascular ARS (Cv-ARS), Cardiovascular ARS (Cr-ARS) Gastrointestinal ARS(GI-ARS), Hematopoietic ARS (H-ARS) -control -were treated with placebo administration. 2. Irradiated animals were treated with antioxidants prophylaxisis and treatment of Cv-ARS, Cr-SRS, GI-ARS, Hp-ARS forms of the ARS. 3. irradiated animals were treated with radioprotection by Antiradiation Vaccine

Three-dimensional, position-sensitive radiation detection

Science.gov (United States)

He, Zhong; Zhang, Feng

2010-04-06

Disclosed herein is a method of determining a characteristic of radiation detected by a radiation detector via a multiple-pixel event having a plurality of radiation interactions. The method includes determining a cathode-to-anode signal ratio for a selected interaction of the plurality of radiation interactions based on electron drift time data for the selected interaction, and determining the radiation characteristic for the multiple-pixel event based on both the cathode-to-anode signal ratio and the electron drift time data. In some embodiments, the method further includes determining a correction factor for the radiation characteristic based on an interaction depth of the plurality of radiation interactions, a lateral distance between the selected interaction and a further interaction of the plurality of radiation interactions, and the lateral positioning of the plurality of radiation interactions.

Intelligent Radiative Materials, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — An opportunity to boost energy efficiency in homes and buildings exists through the design of functional radiative properties in glass and other building materials....

New combined therapy of radiation and local administration of OK-432 for esophageal cancer

International Nuclear Information System (INIS)

Mukai, Minoru; Morita, Shinroku; Tsunemoto, Hiroshi

1990-01-01

We devised new combination therapy of radiation and local administration of OK-432 and performed for 26 patients with esophageal cancer between March, 1987 and December, 1988 as a pilot study. The average age was 73 years. Among 26 patients, males were 20 and females were six. Patients were irradiated at the schedule of under 2 Gy/day and the dose of TDF (time, dose and fractionation factor) 100 totally. OK-432, 10KE was endoscopically administered around cancer lesion at the beginning of the radiotherapy, and two weeks later, 5KE was given in the same manner. Complete response was obtained in 20 out of 26 cases (77%) and partial response was obtained in the remaining six cases (23%). All six patients with tumor length less than five cm showed complete response. All 16 patients who could not eat food orally before treatment, became to take food enough orally after the treatment and could discharge in good condition. One year and two years survival rate of 26 patients by Kaplan Meier method were 67.4% and 47.2%, respectively. Six patients with tumor length less than five cm, are all alive without a sign of recurrence. This combination therapy will improve not only the response rate and the survival rate, but also the quality of life of patients with esophageal cancer. (author)

Considerations on scattering and leak radiation for effective determination of secondary shielding in X-rays rooms of megavoltage

International Nuclear Information System (INIS)

Borges, Diogo da S.; Lava, Deise D.; Affonso, Renato R.W.; Moreira, Maria de L.; Guimaraes, Antonio C.F.

2014-01-01

This paper addresses the development of a algorithm capable of analyzing the thickness of the secondary shielding due to the production of secondary beams. The production of this beam requires consideration of scattering angle, as well as factors normally used for screening of medical facilities using radiographic techniques. Besides the beam emanated from scattering radiation, is is necessary to evaluate the contribution of leakage radiation, originating from equipment used for the production of the primary beam. A view of the mutual contribution of these radiation to the formation of the secondary beam has shown the need of using shieldings in adjacent walls of the room. The code was validated by comparison with an example case provided by NCRP-151 Report. In this report calculations for determining the secondary barrier for small angles are presented, that deserves greater attention for shielding and statements related to radiotherapy procedures of Modulated intensity. The results are consistent with those provided in the report, which makes the code can be used as a practical tool for the determination of effective shielding beams of megavoltage X-rays

Understanding the Role of Public Administration in Implementing Action on the Social Determinants of Health and Health Inequities.

Science.gov (United States)

Carey, Gemma; Friel, Sharon

2015-10-11

Many of the societal level factors that affect health - the 'social determinants of health (SDH)' - exist outside the health sector, across diverse portfolios of government, and other major institutions including non-governmental organisations (NGOs) and the private sector. This has created growing interest in how to create and implement public policies which will drive better and fairer health outcomes. While designing policies that can improve the SDH is critical, so too is ensuring they are appropriately administered and implemented. In this paper, we draw attention to an important area for future public health consideration - how policies are managed and implemented through complex administrative layers of 'the state.' Implementation gaps have long been a concern of public administration scholarship. To precipitate further work in this area, in this paper, we provide an overview of the scholarly field of public administration and highlight its role in helping to understand better the challenges and opportunities for implementing policies and programs to improve health equity. © 2015 by Kerman University of Medical Sciences.

Effect of 60Co γ radiation on hexobarbital-induced sleeping times in rats

International Nuclear Information System (INIS)

Brady, M.E.; Hayton, W.L.

1977-01-01

The duration of the loss of righting reflex (sleeping time) was determined after intraperitoneal administration of 100 mg(/kg hexobarbital to adult male Sprague--Dawley rats that were exposed to 60 Co γ radiation or sham irradiated. No difference between irradiated and control animals was detected at 1, 3, 5, and 7 days after 850 R. Also, no difference between irradiated and control animals was detected at 5 days after 1000 or 1400 R

Protection of the patient in radiation therapy

International Nuclear Information System (INIS)

1991-01-01

In the ICRP report (ICRP-Pub-44) a broad picture of radiotheraphy is presented useful to all involved in the care of cancer patients, for instance to physicians, including medical oncologists, and to medical physicists, radiographers, dosimetrists, and administrators. Information is given on the general principles of radiation therapy including external beam therapy and brachytherapy; the accuracy of radiation delivery and quality assurance; the biological radiation response; the expected risk to specific organs or tissues from therapeutic irradiation; the absorbed dose to tissues inside and outside the useful radiation beams; the organization and planning of radiation oncology services; radiation therapy staff education, training and duties; and finally medical research involving the use of radiation therapy. (orig./HP) [de

COOP Wind and Radiation Observations

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — Wind and radiation data from stations in the National Weather Service Cooperative Observers Network. Some precipitation and pressure forms are mistakenly placed in...

Radiation protection in the Brazilian universities

International Nuclear Information System (INIS)

Caballero, K.C.S.; Borges, J.C.

1994-01-01

A research covering 91 institutions was undertaken in order to elucidate how radiation protection were indeed fulfilled. A questionary including technical administrative and legal subjects was sent by mail and 36% of which were answered propitiating substantial data for analysis. Only in few cases universities have knowledge of basic procedures in radiation protection, claiming for the elaboration of a plan that could guide supervisors and workers in radiation protection in these institution. Based on the tree analysis technique proposed by IAEA, a Reference Radiation protection Program has been elaborated and proposed for Brazilian universities. (author). 14 refs, 1 figs

Quality management in radiation protection

International Nuclear Information System (INIS)

Baehrle, H.G.

1997-01-01

Quality Management in Radiation Protection Quality management (QM) in the field of Radiation Protection was discussed in a previous issue (2/97) using the example of QMS at the Paul Scherrer Institut (PSI). The present article describes the major features involved in the establishment of a functional QMS. Establishment of the QMS lead to a deeper understanding of administrative and operational aspects of the working methods involved. (orig.) [de

Radiation oncology

International Nuclear Information System (INIS)

Anon.

1977-01-01

The Radiation Oncology Division has had as its main objectives both to operate an academic training program and to carry out research on radiation therapy of cancer. Since fiscal year 1975, following a directive from ERDA, increased effort has been given to research. The research activities have been complemented by the training program, which has been oriented toward producing radiation oncologists, giving physicians short-term experience in radiation oncology, and teaching medical students about clinical cancer and its radiation therapy. The purpose of the research effort is to improve present modalities of radiation therapy of cancer. As in previous years, the Division has operated as the Radiation Oncology Program of the Department of Radiological Sciences of the University of Puerto Rico School of Medicine. It has provided radiation oncology support to patients at the University Hospital and to academic programs of the University of Puerto Rico Medical Sciences Campus. The patients, in turn, have provided the clinical basis for the educational and research projects of the Division. Funding has been primarily from PRNC (approx. 40%) and from National Cancer Institute grants channeled through the School of Medicine (approx. 60%). Special inter-institutional relationships with the San Juan Veterans Administration Hospital and the Metropolitan Hospital in San Juan have permitted inclusion of patients from these institutions in the Division's research projects. Medical physics and radiotherapy consultations have been provided to the Radiotherapy Department of the VA Hospital

Flight attendant radiation dose from solar particle events.

Science.gov (United States)

Anderson, Jeri L; Mertens, Christopher J; Grajewski, Barbara; Luo, Lian; Tseng, Chih-Yu; Cassinelli, Rick T

2014-08-01

Research has suggested that work as a flight attendant may be related to increased risk for reproductive health effects. Air cabin exposures that may influence reproductive health include radiation dose from galactic cosmic radiation and solar particle events. This paper describes the assessment of radiation dose accrued during solar particle events as part of a reproductive health study of flight attendants. Solar storm data were obtained from the National Oceanic and Atmospheric Administration Space Weather Prediction Center list of solar proton events affecting the Earth environment to ascertain storms relevant to the two study periods (1992-1996 and 1999-2001). Radiation dose from exposure to solar energetic particles was estimated using the NAIRAS model in conjunction with galactic cosmic radiation dose calculated using the CARI-6P computer program. Seven solar particle events were determined to have potential for significant radiation exposure, two in the first study period and five in the second study period, and over-lapped with 24,807 flight segments. Absorbed (and effective) flight segment doses averaged 6.5 μGy (18 μSv) and 3.1 μGy (8.3 μSv) for the first and second study periods, respectively. Maximum doses were as high as 440 μGy (1.2 mSv) and 20 flight segments had doses greater than 190 μGy (0.5 mSv). During solar particle events, a pregnant flight attendant could potentially exceed the equivalent dose limit to the conceptus of 0.5 mSv in a month recommended by the National Council on Radiation Protection and Measurements.

Mechanism of SOA Formation Determines Magnitude of Radiative Effects

Science.gov (United States)

Zhu, J.; Penner, J.; Lin, G.; Zhou, C.

2017-12-01

Secondary organic aerosol (SOA) nearly always exists as an internal mixture and the distribution of this mixture depends on the formation mechanism of SOA. A model is developed to examine the influence of using an internal mixing states based on the mechanism of formation and to estimate the radiative forcing of SOA in the future. For the present day, 66 % of SOA is internally mixed with sulfate, while 34 % is internally mixed with primary soot. When compared with using an external mixture, the direct effect of SOA is decreased, due to the decrease of total aerosol surface area and the increase of absorption efficiency. Aerosol number concentrations are sharply reduced and this is responsible for a large decrease in the cloud albedo effect. In total, internal mixing suppresses the radiative effect of SOA by a factor of >4 compared to treating SOA as an external mixture. The future SOA burden increases by 24% due to CO2 increases and climate change, leading to a total (direct plus cloud albedo) radiative forcing of -0.05 W m-2. When the combined effects of changes in climate, anthropogenic emissions and land use are included, the SOA forcing is -0.07 W m-2, even though the SOA burden only increases by 6.8%. This is caused by the substantial increase of SOA associated with sulfate in the Aitken mode. The Aitken mode increase contributes to the enhancement of first indirect radiative forcing, which dominates the total radiative forcing.

Substances stimulating recovery for radiation injury

Energy Technology Data Exchange (ETDEWEB)

Takeda, A; Yonezawa, M; Katoh, N [Radiation Center of Osaka Prefecture, Sakai (Japan)

1978-11-01

A relationship between radiation injury and its recovery (intracellular recovery, intercellular recovery, or individual recovery) was discussed. In addition to histological researches in Japan, some substances (free radicals, endotoxin, vaccine, crude drugs, tissue extracts, blood platelet, etc.) stimulating recovery for radiation injury were introduced, and the progress of the study by the authors was summarized. Effects of a root of Panax ginseng (it is believed to accelerate segmentation of marrow cells, and synthesis of DNA and protein in rats and men), methods of its extracting and administration, its influences upon hemogram and organ weight in animal experiments, exclusion of side effects, period of administration, and purification of its effective components were reported.

Spacesuit Evaporator-Absorber-Radiator (SEAR)

Data.gov (United States)

National Aeronautics and Space Administration — The primary goal is to build and test a rigid Lithium Chloride Absorber Radiator (LCAR) coupon based on honeycomb geometry that would be applicable for EVA and...

Diagnosis of acute radiation disease by Enzyme Immune-Assay (EIA)

International Nuclear Information System (INIS)

Popov, D.; Maliev, V.; Jones, J.; Gonta, S.; Prasad, K.; Rachal, C.

2006-01-01

Diagnosis of the acute radiation disease by the method of immune enzyme assay is a simple and efficient tool of evaluating and biological dosimetry and forecasting of development of the acute radiation defeats as at group of population so at individuals locating in the zone polluted by the radiation. We use as biological markers the group of essential radiotoxins - high molecular mass glycoprotein ( molecular mass - 200 - 250 kDa ) - radiation antigens (S.D.R. - specific radiation determinant ) accumulated in the lymphoid system, with epitopes specific to each form of radiation syndrome, after animals have been irradiated in doses inducing the development of the cerebral (1), toxic ( 2), gastrointestinal ( 3 ) and typical ( 4 ) forms of acute radiation sickness. These two phenomena allowed us to develop a technologies for diagnosis, prophylaxis and therapy of radiation disease - enzyme immune assay ( EIA ), anti radiation vaccine, anti radiation serum, method of immune - lymph - plasma-sorption. The important first step in effectiveness of therapy is an accurate assessment of severity of disease in early period after irradiation. The ideal markers for early and accurate assessment is high weight glycoprotein with specifics radiation induced features (S.D.R.) mentioned above. This biology active substance isolated from lymph can induct the symptoms of radiation syndrome without previously radiation when it is administrated intra-muscularly or intravenously to healthy animals. Enzyme immune assay (EIA) allowed researchers to indicate the significant levels of different forms of S.D.R. in peripheral blood of animals in first 24 hours after radiation. Indication of high level of S.D.R. -1 allowed to forecast a fast development of cerebral form of acute radiation disease. Determination of high levels of S.D.R.-2, S.D.R.-3 and S.D.R.-4 in peripheral blood allowed to recognize early periods of toxic, gastrointestinal and typical forms of acute radiation sickness

Diagnosis of acute radiation disease by Enzyme Immune-Assay (EIA)

Energy Technology Data Exchange (ETDEWEB)

Popov, D.; Maliev, V. [Russian Academy of Science, Vladicaukas (Russian Federation); Jones, J.; Gonta, S. [NASA -Johnson Spa ce Center, Houston (United States); Prasad, K. [Antioxidant Research Institute, Premier Micrinutrient corporation, Novato (United States); Rachal, C. [Univercity Space Research Assotiation, Colorado (United States)

2006-07-01

Diagnosis of the acute radiation disease by the method of immune enzyme assay is a simple and efficient tool of evaluating and biological dosimetry and forecasting of development of the acute radiation defeats as at group of population so at individuals locating in the zone polluted by the radiation. We use as biological markers the group of essential radiotoxins - high molecular mass glycoprotein ( molecular mass - 200 - 250 kDa ) - radiation antigens (S.D.R. - specific radiation determinant ) accumulated in the lymphoid system, with epitopes specific to each form of radiation syndrome, after animals have been irradiated in doses inducing the development of the cerebral (1), toxic ( 2), gastrointestinal ( 3 ) and typical ( 4 ) forms of acute radiation sickness. These two phenomena allowed us to develop a technologies for diagnosis, prophylaxis and therapy of radiation disease - enzyme immune assay ( EIA ), anti radiation vaccine, anti radiation serum, method of immune - lymph - plasma-sorption. The important first step in effectiveness of therapy is an accurate assessment of severity of disease in early period after irradiation. The ideal markers for early and accurate assessment is high weight glycoprotein with specifics radiation induced features (S.D.R.) mentioned above. This biology active substance isolated from lymph can induct the symptoms of radiation syndrome without previously radiation when it is administrated intra-muscularly or intravenously to healthy animals. Enzyme immune assay (EIA) allowed researchers to indicate the significant levels of different forms of S.D.R. in peripheral blood of animals in first 24 hours after radiation. Indication of high level of S.D.R. -1 allowed to forecast a fast development of cerebral form of acute radiation disease. Determination of high levels of S.D.R.-2, S.D.R.-3 and S.D.R.-4 in peripheral blood allowed to recognize early periods of toxic, gastrointestinal and typical forms of acute radiation sickness

15 CFR Supplement No. 2 to Part 766 - Guidance on Charging and Penalty Determinations in Settlement of Administrative Enforcement Cases...

Science.gov (United States)

2010-01-01

... suspended on the basis of adverse economic consequences only if it is found that future violations of the... (Continued) BUREAU OF INDUSTRY AND SECURITY, DEPARTMENT OF COMMERCE EXPORT ADMINISTRATION REGULATIONS... as the “antiboycott provisions”). It also describes how BIS makes penalty determinations in the...

Performance Analysis of the Romanian Administration

Directory of Open Access Journals (Sweden)

Marius Constantin PROFIROIU

2013-10-01

Full Text Available The performance of public administration is one of the top priorities of the national governments worldwide, not only for Romania. The role of a performing management system at the level of public administration is to ensure a high quality and efficiency of the adopted policies and strategies, of the provided public services and of the administrative act itself, and to guarantee the advantage of a competitive and efficient administration both in relation to its own citizens, and in competition with other cities and countries throughout Europe and all around the world. Following these considerations, and based upon an empirical research conducted with the aid of a survey regarding ‘The analysis of the performance level of the Romanian public administration’ the article aims to (1 identify modern management tools that determine and influence the performance of Romanian public institutions, (2 analyze the effects of using project management as organizational capacity development instruments by public administration in Romania, and (3 determine the influence and effects of the external factors on the performance and development of Romanian public administration.

Chloroquine Improves Survival and Hematopoietic Recovery After Lethal Low-Dose-Rate Radiation

International Nuclear Information System (INIS)

Lim Yiting; Hedayati, Mohammad; Merchant, Akil A.; Zhang Yonggang; Yu, Hsiang-Hsuan M.; Kastan, Michael B.; Matsui, William; DeWeese, Theodore L.

2012-01-01

Purpose: We have previously shown that the antimalarial agent chloroquine can abrogate the lethal cellular effects of low-dose-rate (LDR) radiation in vitro, most likely by activating the ataxia-telangiectasia mutated (ATM) protein. Here, we demonstrate that chloroquine treatment also protects against lethal doses of LDR radiation in vivo. Methods and Materials: C57BL/6 mice were irradiated with a total of 12.8 Gy delivered at 9.4 cGy/hour. ATM null mice from the same background were used to determine the influence of ATM. Chloroquine was administered by two intraperitoneal injections of 59.4 μg per 17 g of body weight, 24 hours and 4 hours before irradiation. Bone marrow cells isolated from tibia, fibula, and vertebral bones were transplanted into lethally irradiated CD45 congenic recipient mice by retroorbital injection. Chimerism was assessed by flow cytometry. In vitro methylcellulose colony-forming assay of whole bone marrow cells and fluorescence activated cell sorting analysis of lineage depleted cells were used to assess the effect of chloroquine on progenitor cells. Results: Mice pretreated with chloroquine before radiation exhibited a significantly higher survival rate than did mice treated with radiation alone (80% vs. 31%, p = 0.0026). Chloroquine administration before radiation did not affect the survival of ATM null mice (p = 0.86). Chloroquine also had a significant effect on the early engraftment of bone marrow cells from the irradiated donor mice 6 weeks after transplantation (4.2% vs. 0.4%, p = 0.015). Conclusion: Chloroquine administration before radiation had a significant effect on the survival of normal but not ATM null mice, strongly suggesting that the in vivo effect, like the in vitro effect, is also ATM dependent. Chloroquine improved the early engraftment of bone marrow cells from LDR-irradiated mice, presumably by protecting the progenitor cells from radiation injury. Chloroquine thus could serve as a very useful drug for protection

Determination of optimal doses of radiation for the plant breeding of pseudo cereals

International Nuclear Information System (INIS)

Gonzalez J, J.; Gomez P, L.

2005-01-01

With the purpose of promoting the use of the radiations for the plant breeding of pseudo cereals, it was determined a simple and economic method that allows the quick selection of radiation dose that induce in the vegetable organisms the changes wanted. For it it was work with quinua seeds (Chenopodium quinoa Willd.) an Andean pseudo cereal that, due to their nutritious and physiologic characteristics it is considered by the FAO like one of the foods of the future and for the NASA like an organism that is good to remove the carbon dioxide from the atmosphere and at the same time, to generate food, oxygen and water for the crew during the space missions of long duration and that it has already improved by means of the radiation application. The proposed method consists on the evaluation, of the embryonic structures (radicule, hypocotyl and cotyledons) in the irradiated seeds as well as of the development of root, primary shaft and true leaves in the plants. The changes in the growth, form, number and color of the structures as well as the time of appearance of each one, allow to predict the morphological changes and inclusive some physiologic ones that will have the mature organisms, so that in only three weeks it is possible to select the doses more appropriate. (Author)

A computer simulation study of optimal thyroid radiation protection during investigations involving the administration of radioiodine-labelled pharmaceuticals

International Nuclear Information System (INIS)

Wootton, R.; Hammond, B.J.

1978-01-01

The administration of iodide for thyroid blocking is now known to carry its own risks, at least in certain categories of patients. A theoretical study has been made by computer simulation of the efficacy of various thyroid blocking regimes. In the case of injected 125 I- or 131 I-iodide, substantial thyroid protection may theoretically be achieved by a single oral dose of inorganic iodide, for example a 90% reduction in radiation dose is produced by only 20 mg iodide. Repeating the initial blocking dose is of little value. A single blocking dose, however, affords poor protection against radioiodine released from labelled plasma proteins. Both for short-lived proteins such as fibrinogen, and for the longer-lived proteins such as albumin, the optimum dosage schedule appears to be stable iodide given daily for two to three weeks. For instance, 10 mg daily for a fortnight will reduce thyroid irradiation by a factor of ten following injections of 125 I-fibrinogen. (author)

Real-Time Scintigraphic Assessment of Intravenous Radium-223 Administration for Quality Control

Directory of Open Access Journals (Sweden)

Chadwick L. Wright

2015-01-01

Full Text Available Radium-223 (223Ra dichloride is an approved intravenous radiotherapy for patients with osseous metastases from castration-resistant prostate cancer (CRPC. In addition to the therapeutic alpha radiation, there is additional 223Ra radiation generated which produces photons that can be imaged with conventional gamma cameras. No studies have evaluated real-time and quality imaging during intravenous 223Ra administration to verify systemic circulation and exclude 223Ra extravasation at the injection site. A retrospective review was performed for fifteen 223Ra administrations for CRPC patients which were imaged using a large field of view portable gamma camera (LFOVPGC for the purposes of quality control and patient safety. Dynamic imaging of the chest was performed before, during, and after the 223Ra administration to verify systemic circulation, per institutional clinical protocol. Before and after 223Ra administration, a static image was obtained of the intravenous access site. Dynamic imaging of the chest confirmed systemic administration early during the 1-minute injection period for all patients. There were no cases of focal 223Ra extravasation at the site of intravenous access. These results verify that systemic 223Ra administrations can be quantified with real-time imaging using an LFOVPGC. This simple approach can confirm and quantify systemic circulation of 223Ra early during injection and exclude focal extravasation for the purposes of quality control.

Occupational radiation doses among diagnostic radiation workers in South Korea, 1996-2006

International Nuclear Information System (INIS)

Lee, W. J.; Cha, E. S.; Ha, M.; Jin, Y. W.; Hwang, S. S.; Kong, K. A.; Lee, S. W.; Lee, H. K.; Lee, K. Y.; Kim, H. J.

2009-01-01

This study details the distribution and trends of doses of occupational radiation among diagnostic radiation workers by using the national dose registry between 1996 and 2006 by the Korea Food and Drug Administration. Dose measurements were collected quarterly by the use of thermoluminescent dosemeter personal monitors. A total of 61 732 workers were monitored, including 18 376 radiologic technologists (30%), 13 762 physicians (22%), 9858 dentists (16%) and 6114 dental hygienists (9.9%). The average annual effective doses of all monitored workers decreased from 1.75 to 0.80 mSv over the study period. Among all diagnostic radiation workers, radiologic technologists received both the highest effective and collective doses. Male radiologic technologists aged 30-49 y composed the majority of workers receiving more than 5 mSv in a quarter. More intensive monitoring of occupational radiation exposure and investigation into its health effects on diagnostic radiation workers are required in South Korea. (authors)

X and gamma reference radiation for calibrating dosemeters and doserate meters and for determining their response as a function of photon energy - Part 4: Calibration of area and personal dosemeters in low energy X reference radiation fields

International Nuclear Information System (INIS)

2004-01-01

ISO 4037 consists of the following parts, under the general title X and gamma reference radiation for calibrating dosemeters and doserate meters and for determining their response as a function of photon energy: Part 1: Radiation characteristics and production methods; Part 2: Dosimetry for radiation protection over the energy ranges from 8 keV to 1,3 MeV and 4 MeV to 9 MeV; Part 3: Calibration of area and personal dosemeters and the measurement of their response as a function of energy and angle of incidence; Part 4: Calibration of area and personal dosemeters in low energy X reference radiation fields. This part 4. of ISO 4037 gives guidelines on additional aspects of the characterization of low energy photon radiations. This part of ISO 4037 also describes procedures for calibration and determination of the response of area and personal dose(rate)meters as a function of photon energy and angle of incidence. This part of ISO 4037 concentrates on the accurate determination of conversion coefficients from air kerma to Hp(10) and H*(10) for the spectra of low energy photon radiations. As an alternative to the use of conversion coefficients, the direct calibration in terms of these quantities by means of appropriate reference instruments is described

Personnel ionizing radiation dosimeter

International Nuclear Information System (INIS)

Williams, R.A.

1975-01-01

A dosimeter and method for use by personnel working in an area of mixed ionizing radiation fields for measuring and/or determining the effective energy of x- and gamma radiation; beta, x-, and gamma radiation dose equivalent to the surface of the body; beta, x-, and gamma radiation dose equivalent at a depth in the body; the presence of slow neutron, fast neutron dose equivalent; and orientation of the person wearing the dosimeter to the source of radiation is disclosed. Optionally integrated into this device and method are improved means for determining neutron energy spectrum and absorbed dose from fission gamma and neutron radiation resulting from accidental criticality

Feasibility of a novel approach for fast, economical determination of radiation damage in nuclear reactor cores

International Nuclear Information System (INIS)

Was, G.S.

1993-01-01

Progress was made in the following areas: radioinduced segregation (modeling and experiment), deformation of irradiated microstructures, stress corrosion cracking of irradiated microstructures, and development of an apparatus to determine the role of deformation on the radiation microstructure in-situ. Materials used were based on Ni-Cr-Fe and 304L

1988 annual work report of the Department for Safety and Radiation Protection

International Nuclear Information System (INIS)

Hille, R.

1989-03-01

The Department for Safety and Radiation Protection continues to be responsible for coordinating radiation protection, safety and protection at the KFA. It supports the other institutes and departments in performing the safety tasks allotted to them. The principal tasks of the Department are in administrative and technical assistance to these organization units and in safeguards. Administrative assistance involves, for example, regulation of the radiation protection organization in the institutes, including the appointment of radiation protection officers (Strahlenschutzbeauftragte). Furthermore, this includes the central handling of the registration system with the authorities and dealing with outside firms thus considerably relieving the institutes of their administrative tasks. Handling licensing procedures and the central accountancy of radioactive materials is also to be mentioned in this context. Technical assistance largely consists of developing, maintaining and repairing radiation measuring instruments and in the monitoring of personnel by evaluating personnel dosimeters and incorporation controls for radioactive sources. The safeguards tasks of the Department concern the very staff-intensive physical protection, as well as environmental protection and industrial safety. (orig.) [de

Nanocomposite for Radiation Shielding, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — NASA's Advanced Extravehicular Activity (EVA) program requires the need for materials that can protect astronauts and spacecrafts from ionizing radiations such as...

Hybrid Active-Passive Radiation Shielding System

Data.gov (United States)

National Aeronautics and Space Administration — A radiation shielding system is proposed that integrates active magnetic fields with passive shielding materials. The objective is to increase the shielding...

DOE 2012 occupational radiation exposure

Energy Technology Data Exchange (ETDEWEB)

none,

2013-10-01

The U.S. Department of Energy (DOE) Office of Analysis within the Office of Health, Safety and Security (HSS) publishes the annual DOE Occupational Radiation Exposure Report to provide an overview of the status of radiation protection practices at DOE (including the National Nuclear Security Administration [NNSA]). The DOE 2012 Occupational Radiation Exposure Report provides an evaluation of DOE-wide performance regarding compliance with Title 10, Code of Federal Regulations (C.F.R.), Part 835, Occupational Radiation Protection dose limits and as low as reasonably achievable (ALARA) process requirements. In addition, the report provides data to DOE organizations responsible for developing policies for protection of individuals from the adverse health effects of radiation. The report provides a summary and an analysis of occupational radiation exposure information from the monitoring of individuals involved in DOE activities. Over the past 5-year period, the occupational radiation exposure information is analyzed in terms of aggregate data, dose to individuals, and dose by site.

DOE 2011 occupational radiation exposure

Energy Technology Data Exchange (ETDEWEB)

none,

2012-12-01

The U.S. Department of Energy (DOE) Office of Analysis within the Office of Health, Safety and Security (HSS) publishes the annual DOE Occupational Radiation Exposure Report to provide an overview of the status of radiation protection practices at DOE (including the National Nuclear Security Administration [NNSA]). The DOE 2011 Occupational Radiation Exposure Report provides an evaluation of DOE-wide performance regarding compliance with Title 10, Code of Federal Regulations (C.F.R.), Part 835, Occupational Radiation Protection dose limits and as low as reasonably achievable (ALARA) process requirements. In addition, the report provides data to DOE organizations responsible for developing policies for protection of individuals from the adverse health effects of radiation. The report provides a summary and an analysis of occupational radiation exposure information from the monitoring of individuals involved in DOE activities. The occupational radiation exposure information is analyzed in terms of aggregate data, dose to individuals, and dose by site over the past five years.

DOE 2013 occupational radiation exposure

Energy Technology Data Exchange (ETDEWEB)

none,

2014-11-01

The Office of Analysis within the U.S. Department of Energy (DOE) Office of Environment, Health, Safety and Security (EHSS) publishes the annual DOE Occupational Radiation Exposure Report to provide an overview of the status of radiation protection practices at DOE (including the National Nuclear Security Administration [NNSA]). The DOE 2013 Occupational Radiation Exposure Report provides an evaluation of DOE-wide performance regarding compliance with Title 10, Code of Federal Regulations (C.F.R.), Part 835, Occupational Radiation Protection dose limits and as low as reasonably achievable (ALARA) process requirements. In addition, the report provides data to DOE organizations responsible for developing policies for protection of individuals from the adverse health effects of radiation. The report provides a summary and an analysis of occupational radiation exposure information from the monitoring of individuals involved in DOE activities. Over the past five-year period, the occupational radiation exposure information has been analyzed in terms of aggregate data, dose to individuals, and dose by site.

Determination of the distribution of graft yields following a radiation-induced graft copolymerization

International Nuclear Information System (INIS)

Schipschack, K.; Wagner, H.; Sawtschenko, L.

1976-01-01

In the radiation-induced graft copolymerization on solid initial polymers a distribution of graft yields takes place along the cross-sections of samples. Methods for determining this distribution, which are described in the literature, are reviewed. In our own investigations boards made of ethylene-vinyl acetate copolymers and grafted with vinyl chloride were used. Distributions of the grafted component obtained by infrared analysis of microtome cuts parallel to the surface are partly rather inhomogeneous, and are interpreted as dependent on the experimental parameters. (author)

Topics in radiation dosimetry radiation dosimetry

CERN Document Server

1972-01-01

Radiation Dosimetry, Supplement 1: Topics in Radiation Dosimetry covers instruments and techniques in dealing with special dosimetry problems. The book discusses thermoluminescence dosimetry in archeological dating; dosimetric applications of track etching; vacuum chambers of radiation measurement. The text also describes wall-less detectors in microdosimetry; dosimetry of low-energy X-rays; and the theory and general applicability of the gamma-ray theory of track effects to various systems. Dose equivalent determinations in neutron fields by means of moderator techniques; as well as developm

Integrated Radiation Analysis and Design Tools

Data.gov (United States)

National Aeronautics and Space Administration — The Integrated Radiation Analysis and Design Tools (IRADT) Project develops and maintains an integrated tool set that collects the current best practices, databases,...

High Efficency Lightweight Radiators, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — XC Associates proposes to build on prior work to develop and characterize a very high efficiency, lightweight radiator constructed from high thermal conductivity...

Modeling silica aerogel optical performance by determining its radiative properties

Directory of Open Access Journals (Sweden)

Lin Zhao

2016-02-01

Full Text Available Silica aerogel has been known as a promising candidate for high performance transparent insulation material (TIM. Optical transparency is a crucial metric for silica aerogels in many solar related applications. Both scattering and absorption can reduce the amount of light transmitted through an aerogel slab. Due to multiple scattering, the transmittance deviates from the Beer-Lambert law (exponential attenuation. To better understand its optical performance, we decoupled and quantified the extinction contributions of absorption and scattering separately by identifying two sets of radiative properties. The radiative properties are deduced from the measured total transmittance and reflectance spectra (from 250 nm to 2500 nm of synthesized aerogel samples by solving the inverse problem of the 1-D Radiative Transfer Equation (RTE. The obtained radiative properties are found to be independent of the sample geometry and can be considered intrinsic material properties, which originate from the aerogel’s microstructure. This finding allows for these properties to be directly compared between different samples. We also demonstrate that by using the obtained radiative properties, we can model the photon transport in aerogels of arbitrary shapes, where an analytical solution is difficult to obtain.

Modeling silica aerogel optical performance by determining its radiative properties

Science.gov (United States)

Zhao, Lin; Yang, Sungwoo; Bhatia, Bikram; Strobach, Elise; Wang, Evelyn N.

2016-02-01

Silica aerogel has been known as a promising candidate for high performance transparent insulation material (TIM). Optical transparency is a crucial metric for silica aerogels in many solar related applications. Both scattering and absorption can reduce the amount of light transmitted through an aerogel slab. Due to multiple scattering, the transmittance deviates from the Beer-Lambert law (exponential attenuation). To better understand its optical performance, we decoupled and quantified the extinction contributions of absorption and scattering separately by identifying two sets of radiative properties. The radiative properties are deduced from the measured total transmittance and reflectance spectra (from 250 nm to 2500 nm) of synthesized aerogel samples by solving the inverse problem of the 1-D Radiative Transfer Equation (RTE). The obtained radiative properties are found to be independent of the sample geometry and can be considered intrinsic material properties, which originate from the aerogel's microstructure. This finding allows for these properties to be directly compared between different samples. We also demonstrate that by using the obtained radiative properties, we can model the photon transport in aerogels of arbitrary shapes, where an analytical solution is difficult to obtain.

Radiation exposure of radiographers who handle 18 F ...

African Journals Online (AJOL)

18F-fluorodeoxyglucose (18F-FDG) is used in most diagnostic applications of Positron Emission Tomography (PET). It has high annihilation energy of 511 keV, which results in potentially high radiation doses for staff. This study investigated radiographer radiation exposure during receipt, administration and scanning of ...

An initial report of polaprezinc suppositories to radiation proctitis

International Nuclear Information System (INIS)

Doi, Hiroshi; Kamikonya, Norihiko; Takada, Yasuhiro

2010-01-01

Although radiation proctitis is one of popular adverse effects, standard treatments are not established. We reported 5 cases with the administration of polaprezinc suppositories to radiation proctitis. We made polaprezinc suppositories and administered to 5 patients with radiation proctitis. It was possible to administer it safely. 3 cases have the improvement of the symptoms. And one case had endoscopic findings improved significantly. Polaprezinc may be one of the treatments to radiation proctitis. (author)

Synergistic tumorigenic effect of procarbazine and ionizing radiation in (BALB/c x DBA/2)F1 mice

International Nuclear Information System (INIS)

Arseneau, J.C.; Fowler, E.; Bakemeier, R.F.

1977-01-01

Female (BALB/c x DBA/2)F, (CD2F 1 ) mice were treated with procarbazine (PCB) and ionizing radiation at different times to determine whether any synergistic carcinogenic effect could be demonstrated with the combined treatment. The incidence of pulmonary adenomas in groups of mice receiving both PCB and radiation increased significantly, when compared with mice given PCB alone. The incidence of thymomas also increased significantly in groups of mice given PCB 3 days before or after radiation treatment. Two cases of adenocarcinoma apparently arising from the lacrimal gland were also observed in mice from the groups receiving the combined treatment. This tumor had not previously been associated with PCB administration in mice. The results of this experiment indicated a potentiation of the tumorigenic action of PCB by ionizing radiation in CD2F 1 mice

The distribution of radioiodine administrated to pregnant mice and the effect of non radioactive iodide

International Nuclear Information System (INIS)

Okui, Toyo; Kobayashi, Satoshi

1987-01-01

Radioiodine, 131 I, which has a high fission yield in the nuclear reactor, is easily taken into the human body, accumilating in the thyroid gland, when released to the environment. 131 I was administrated orally to pregnant mice, and its transportation to the tissues, particularly the fetus, was examined closely. And further, the non-radioactive iodide, i.e., KI, was administrated to see its radiation protection effect. The transportation of 131 I to the fetus is the second highest, following the thyroid gland in the mother mouse. This transportation to the fetus becomes the higher, the larger the gestation period at which the 131 I administration is made. The administration of the non-radioactive iodide has large radiation protection effect in the thyroid gland of the mother mouse and of the fetus. But, depending on its concentration, the non-radioactive iodide may conversely increase overall exposure of the fetus. (Mori, K.)

Multifunctional BHL Radiation Shield, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — Advances in radiation shielding technology remain an important challenge for NASA in order to protect their astronauts, particularly as NASA grows closer to manned...

Effects of beer administration in mice on acute toxicities induced by X rays and carbon ions

International Nuclear Information System (INIS)

Monobe, Manami

2003-01-01

We have investigated the tissue specificity of radioprotection by beer, which was previously found for human lymphocytes. C3H/He female mice, aged 14 weeks, received an oral administration of beer, ethanol or saline at a dose of 1 ml/mouse 30 min before whole-body irradiation with 137 Cs γ rays or 50 keV/μm carbon ions. The dicentrics of chromosome aberrations in spleen cells were significantly (p 0 (slope of a dose-survival curve) for γ rays and carbon ions as well. Beer administration significantly (p 50/30 (radiation dose required to kill 50% of mice within 30 days) for γ rays and carbon ions. Ethanol-administration also significantly (p 50/30 value for γ rays, but not for carbon ions. It is concluded that beer administration reduces the radiation injury caused by photons and carbon ions, depending on the tissue type. Radioprotection by beer administration is not solely due to OH radical-scavenging action by the ethanol contained in beer. (author)

77 FR 25678 - International Trade Administration

Science.gov (United States)

2012-05-01

... DEPARTMENT OF COMMERCE International Trade Administration Antidumping or Countervailing Duty Order..., International Trade Administration, Department of Commerce. Background Every five years, pursuant to section 751...'') and the International Trade Commission automatically initiate and conduct a review to determine...

Historical overview of radiation exposure guidance on radioactive consumer products

International Nuclear Information System (INIS)

Tapert, A.C.

1978-01-01

This paper is an historical overview of radiation exposure recommendations suggested by several commissions, committees, and agencies. Guidelines issued by the International Commission of Radiological Protection, International Atomic Energy Agency, Federal Radiation Council, Nuclear Energy Agency (formerly the European Nuclear Energy Agency), National Council on Radiation Protection and Measurements, Food and Drug Administration, Conference of Radiation Control Program Directors, and the US Nuclear Regulatory Commission are discussed

Radiation protection research projects. Program report 2015. Report on research program radiation protection of the Federal ministry for environment, nature conservation and reactor safety with technical and administrative steering by the Bundesamt fuer Strahlenschutz; Strahlenschutzforschung. Programmreport 2015. Bericht ueber das vom Bundesamt fuer Strahlenschutz fachlich begleitete und administrativ umgesetzte Forschungsprogramm Strahlenschutz des Bundesministeriums fuer Umwelt, Naturschutz, Bau und Reaktorsicherheit

Energy Technology Data Exchange (ETDEWEB)

Schmitt-Hannig, Annemarie; Loebke-Reinl, Angelika; Peter, Josef; Goedde, Ralph; Hachenberger, Claudia; Trugenberger-Schnabel, Angela (comps.)

2016-08-15

On behalf of the Federal Ministry for the Environment, Nature Conservation, Building and Nuclear Safety (BMUB) the Federal Office for Radiation Protection (BfS) awards research grants for projects in the field of radiation protection. The findings of these projects serve as decision aiding information in the development of radiation protection regulations as well as in the fulfilment of specific tasks in the field of radiation protection. The tasks of the Federal Office for Radiation Protection involve planning, technical and administrative preparation, awarding of contracts, general support as well as the technical evaluation of research and study projects. This report provides information on results, i. e. preliminary (in the form of status reports) and, where applicable, final results of radiation protection projects within the BMUB's Environmental Research Plan for the year 2015.

Factors determining the viability of radiation processing in developing countries

International Nuclear Information System (INIS)

Linde, H.J. van der

1988-01-01

In the fifteen years since the introduction of radiation processing to South Africa, four commercial irradiation facilities have been established. These are involved in the processing of a large variety of products, from syringes and prostheses to strawberries and sugar yeast. Three of the facilities are devoted mainly to food irradiation and several thousand tonnes are now processed annually. During this period it was repeatedly experienced that the successful introduction of radiation processing in general, and food radurization in particular, on a commercial scale was critically dependent on the following factors: acceptance by the producer, industry and consumer; initial capital expenditure; running costs and overheads in general; and continuous throughput. All of these factors contribute to the processing cost which is the ultimate factor in determining the value/price ratio for the potential entrepreneur and customer of this new technology. After a market survey had identified the need for a new food irradiation facility to cope with the growing interest in commercial food radurization in the Western Cape, the above-mentioned factors were of cardinal importance in the design and manufacture of a new irradiator. The resulting batch-pallet facility which was commissioned in August 1986, is rather inefficient as far as energy utilization is concerned but this shortcoming is compensated for by its low cost, versatility and low hold-up. Although the facility has limitations as far as the processing of really large volumes of produce is concerned, it is particularly suitable not only for developing countries, but for developed countries in the introductory phase of commercial food radurization. (author)

GEWEX Surface Radiation Budget (SRB)

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The NASA/GEWEX Surface Radiation Budget (SRB) Release-3.0 data sets contains global 3-hourly, daily, monthly/3-hourly, and monthly averages of surface and top-of...

Radiation-induced increases in sensitivity of cataleptic behavior to haloperidol: possible involvement of prostaglandins

International Nuclear Information System (INIS)

Joseph, J.A.; Kandasamy, S.B.; Hunt, W.A.; Dalton, T.K.; Stevens, S.

1988-01-01

The effects of radiation exposure on haloperidol-induced catalepsy were examined in order to determine whether elevated prostaglandins, through an action on dopaminergic autoreceptors, could be involved in the radiation-induced increase in the potency of this neuroleptic. Cataleptic behavior was examined in animals irradiated with various doses of gamma photons (1-150 Gy) and pretreated with a subthreshold dose of haloperidol (0.1 mg/kg). This approach was chosen to maximize any synergistic effects of radiation and haloperidol. After irradiation with doses less than or equal to 30 Gy, the combined treatment of haloperidol and radiation produced catalepsy, whereas neither treatment alone had an effect. This observed catalepsy could be blocked with prior administration of indomethacin, a prostaglandin synthesis inhibitor. Animals exposed to doses of radiation less than or equal to 50 Gy and no haloperidol, however, displayed apparent catalepsy. This effect was also antagonized by indomethacin. Prostaglandins can induce catalepsy and when administered in subthreshold doses along with subthreshold doses of haloperidol, catalepsy was observed. In order to assess a possible action of prostaglandins and radiation on dopaminergic activity, the functioning of striatal dopaminergic autoreceptors was examined by determining the effects of varying concentrations of haloperidol on the K+-evoked release of dopamine from striatal slices obtained from parallel groups of animals treated as above. Results indicated that sensitivity to haloperidol increased (higher K+-evoked dopamine release) in slices from irradiated or prostaglandin-treated animals and that this increase in sensitivity was blocked by indomethacin

Management organization and administration for ALARA

International Nuclear Information System (INIS)

Kathren, R.L.

1982-01-01

The fundamentals of organizational structure and administration as applied to the goal of keeping occupational radiation exposures as low as reasonably achievable are discussed, including consideration of management commitment, organizational separation of health physics functions, reporting levels, designation of responsibility and authority and adequacy of personnel and funding. Examples of good and poor organizational structures are shown, and the role and implementation of ALARA committees, effective communications, and review and audit processes are discussed. (author)

Evaluation of radiation doses from radioactive drugs

International Nuclear Information System (INIS)

Halperin, J.A.; Grove, G.R.

1977-01-01

Radioactive new drugs are regulated by the Food and Drug Administration (FDA) in the United States. Before a new drug can be marketed it must have an approved New Drug Application (NDA). Clinical investigations of a radioactive new drug are carried out under a Notice of Claimed Investigational Exemption for a New Drug (IND), submitted to the FDA. In the review of the IND, radiation doses are projected on the basis of experimental data from animal models and from calculations based upon radiation characteristics, predicted biodistribution of the drug in humans, and activity to be administered. FDA physicians review anticipated doses and prevent clinical investigations in humans when the potential risk of the use of a radioactive substance outweighs the prospect of achieving beneficial results from the administration of the drug. In the evaluation of an NDA, FDA staff attempt to assure that the intended diagnostic or therapeutic effect is achievable with the lowest practicable radiation dose. Radiation doses from radioactive new drugs are evaluated by physicians within the FDA. Important radioactive new drugs are also evaluated by the Radiopharmaceuticals Advisory Committee. FDA also supports the Center for Internal Radiation Dosimetry at Oak Ridge, to provide information regarding in vivo distribution and dosimetry to critical organs and the whole body from radioactive new drugs. The process for evaluation of radiation doses from radioactive new drugs for protection against use of unnecessary radiation exposure by patients in nuclear medicine procedures, a

Oral administration of an estrogen metabolite-induced potentiation of radiation antitumor effects in presence of wild-type p53 in non-small-cell lung cancer

International Nuclear Information System (INIS)

Huober, Jens B.; Nakamura, Seiichi; Meyn, Ray; Roth, Jack A.; Mukhopadhyay, Tapas

2000-01-01

Purpose: The purpose of this study was to investigate the efficacy of 2-methoxyestradiol as an antitumor and radiosensitizing agent for the treatment of human malignancy. Methods and Materials: Two cancer cell lines with wild-type p53 status were exposed first to irradiation and then to an oral formulation of the nontoxic metabolite 2-methoxyestradiol (2ME) to stabilize p53 levels. Results: Cell growth was inhibited via G1 growth and apoptosis. Subsequent in vitro growth and Tunel assays indicated that this combination was superior to radiation alone at inducing p53 protein accumulation, stabilizing p53 protein levels, and substantially reducing long-term tumor cell growth (∼80%) and colony formation (∼95%) in vitro, and inducing apoptosis. However, harboring mutated p53, H322 cell line, was relatively insensitive to such a treatment regimen. Western blot analysis revealed that growth inhibition was associated with increased levels of p53 and p21 protein accumulation. Experiments with subcutaneous tumor in a nu/nu mouse showed the combination treatment to be superior to radiation alone at reducing tumor growth (∼50% reduction as compared to radiation alone) in vivo. Conclusion: Thus, our studies confirmed a unique strategy whereby oral administration of a nontoxic estrogen metabolite, 2ME, significantly enhanced the radiation effect on a subcutaneous tumor without any toxicity and suggesting that this strategy may be clinically useful as an adjuvant therapy

Determination of the effective radiative lifetimes of the 6 3P1 atomic mercury level in low-pressure mercury discharges

International Nuclear Information System (INIS)

van de Weijer, P.; Cremers, R.M.M.

1984-01-01

Experiments are described in which low-pressure mercury, mercury-argon and mercury-krypton discharges were irradiated with a dye laser pulse at 365.5 nm, thus exciting mercury atoms from the metastable 6 3 P 2 level to the 6 3 D 2 level. The 6 3 D 2 level decays radiatively to the 6 P levels. By recording the time dependence of the overpopulation in the 6 3 P 1 and the 6 1 P 1 level at the fluorescence signals at 254 nm and 185 nm, respectively, the effective radiative lifetime of these levels were determined. The effective radiative lifetime of the 6 3 P 1 level was measured in the k 0 R regime 0.1-500. The 6 1 P 1 lifetime was determined for the following discharge conditions: tube diameter 10-36 mm, mercury density 7.10 18 -2.10 21 m -3 , and noble gas pressure 0, 130, 400 Pa

Novel Concepts for Radiation Shielding Materials

Data.gov (United States)

National Aeronautics and Space Administration — The likelihood of safely sending astronauts to Mars is becoming bleaker because of the health risks that would result from exposure to galactic cosmic radiation...

Metals determination in wood treated by synchrotron radiation X-ray fluorescence analysis

International Nuclear Information System (INIS)

Vives, Ana Elisa Sirito de; Medeiros, Jean Gabriel da Silva; Tomazello Filho, Mario

2005-01-01

The paper describes the use of X-Ray fluorescence analysis for distribution and quantification of metals in the hardwood (Eucalyptus sp) and softwood (Pinus sp) treated with CCA (copper-chromium-arsenic). The sapwood/heartwood for hardwood sample and the growth-rings for softwood sample were analyzed. The samples were scanned in 320 mm steps in the vertical direction. For excitation of the elements a white beam synchrotron radiation of ∼ 320 x 180 mm was employed and for the X-ray detection a Si(Li) semiconductor detector. The elements K, Ca, Cr, Mn, Cu, Zn and As were determined. Fundamental parameters were used to quantify the elements concentrations. (author)

Metals determination in wood treated by synchrotron radiation X-ray fluorescence analysis

Energy Technology Data Exchange (ETDEWEB)

Vives, Ana Elisa Sirito de [Universidade Metodista de Piracicaba (UNIMEP), Santa Barbara D' Oeste, SP (Brazil). Faculdade de Engenharia, Arquitetura e Urbanismo]. E-mail: aesvives@unimep.br; Silva, Richard Maximiliano da Cunha [Centro de Energia Nuclear na Agricultura, Piracicaba, SP (Brazil)]. E-mail: maxcunha@cena.usp.br; Medeiros, Jean Gabriel da Silva; Tomazello Filho, Mario [Sao Paulo Univ., Piracicaba, SP (Brazil). Escola Superior de Agricultura Luiz de Queiroz]. E-mail: jeangm@esalq.usp.br; mtomazel@esalq.usp.br; Moreira, Silvana [Universidade Estadual de Campinas, SP (Brazil). Faculdade de Engenharia Civil, Arquitetura e Urbanismo]. E-mail: Silvana@fec.unicamp.br; Zucchi, Orgheda Luiza Araujo Domingues [Sao Paulo Univ., Ribeirao Preto, SP (Brazil). Faculdade de Ciencias Farmaceuticas]. E-mail: olzucchi@fcfrp.usp.br; Barroso, Regina Cely [Universidade do Estado, Rio de Janeiro, RJ (Brazil)]. E-mail: cely@uerj.br

2005-07-01

The paper describes the use of X-Ray fluorescence analysis for distribution and quantification of metals in the hardwood (Eucalyptus sp) and softwood (Pinus sp) treated with CCA (copper-chromium-arsenic). The sapwood/heartwood for hardwood sample and the growth-rings for softwood sample were analyzed. The samples were scanned in 320 mm steps in the vertical direction. For excitation of the elements a white beam synchrotron radiation of {approx} 320 x 180 mm was employed and for the X-ray detection a Si(Li) semiconductor detector. The elements K, Ca, Cr, Mn, Cu, Zn and As were determined. Fundamental parameters were used to quantify the elements concentrations. (author)

Radiation safety and formation of public opinion

International Nuclear Information System (INIS)

Qurbanov, M.

2002-01-01

Full text: Team-administrative system of long years has been a reason of environmental pollution and health consequences and still does. This includes soil pollution with pesticides, ecological condition of micro and macro flora of the Caspian Sea, soil pollution with oil, deforestation and etc. Scientists and environmental NGOs have given some information to public and public opinion has already been formed on this issue. But public opinion is not necessarily formed on radiation - the most important and invisible problem. The reason of this is that radiation danger has been hidden as a closed theme from the public. After the soviet collapse this problem is also being revealed. Number of NGOs have held the seminar on this issue and given some information to public. The researches cover the following problems:To hold the public monitoring in the fields polluted with oil and separate it from the other fields by determining the fields polluted with radiation. To take measures in order to prevent public entrance to these fields; To inform about the usage of radiation based equipment in the industrial fields and to hold the regular monitoring; To advertise the differential signs of radiation sources in the city landfill and other polluted zones; To broaden the advocacy on ultraviolet rays and their influence to human health; To disseminate the brochures and advertisement papers on high technical radiation and their influence to human health; To analyze the radio environmental condition around the Gabala Radar Station; To advocate the possible radiation danger in using the x-ray and other medical equipment; Analyze the possible radon danger in shipping materials; To create the idea on possible transition of radioactive gases and elements from neighbor countries; Creation of idea on possible danger around the high voltage. The formation of public opinion on mentioned problem will depend on combining the scientists' and NGOs activities

Assay of new systems in vivo mutagenesis for determining the effects of low doses of ionizing radiation

International Nuclear Information System (INIS)

Bauluz, C.; Sierra, I.; Martin, L.; Real, A.; Vidania, R. de

1997-01-01

Ionizing radiation reacts directly and indirectly with the genetic material in living cells and produces DNA damage. Processing of this damage by correcting enzymes may result in appearing of mutations which, in turn, may lead to carcinogenesis. We have focused on the determination of in vivo mutagenesis induced after exposure to X-rays, aiming at establishing methods to evaluate the effect of low doses of radiation. In vivo mutagenesis has been addressed in the Muta Mouse model that carries a lacZ marker gene and provides a relatively simple assay of appearance of mutations. Mutation frequencies were determined in the lacZ gene copies recovered from mice irradiated with 1Gy or 4Gy of X-rays, acute or fractionated. Liver, spleen and bone marrow DNA samples were isolated at different times after irradiation, ranging from 1 day to 2 months, and evolution of mutations was studied. Results showed different responses depending on the organ and especially on the time of analysis, suggesting that the mutagenic process in vivo is much more complex than previously deduced from in vitro experiments. Therefore, determination of the relationship between dose and mutagenic effect in vivo will require additional studies. (author)

Diagnosis of acute radiation disease by enzyme immune-assay (EIA)

International Nuclear Information System (INIS)

Popov, D.; Maliev, V.

2005-01-01

Full text: Multifactor fundamental research under experimental and industrial conditions on farm and laboratory animals and also on humans blood serum of Chernobyl NPP clean-up workers conducted within 1982 - 2002 have enabled us to establish the existence of two previously unknown phenomena: the phenomenon of reversible redistribution of cytobiochemical parameters in the blood-interstices-lymph-blood system of irradiated animals, which supports compensatory maintenance of homeostasis. The phenomenon of specific immunochemical reactions to the radiological effect, involving the formation of high molecular mass glycoprotein (molecular mass - 200 - 250 kDa) - radiation antigens (SDR - specific radiation determinant) in the lymphoid system with epitopes specific to each form of radiation syndrome, after animals have been irradiated in doses inducing the development of the cerebral (1) , toxic (2) gastrointestinal (3) and typical (4) forms of acute radiation sickness. These two phenomena allowed us to develop a technologies for diagnosis, prophylaxis and therapy of radiation disease - enzyme immune assay (EIA), antiradiation vaccine, antiradiation serum, method of immune-lymph-plasmosorption. The important first step in effectiveness of therapy is an accurate assessment of severity of disease in early period after irradiation. The ideal markers for early and accurate assessment is high weight glycoprotein with specifics radiation induced features (SDR) mentioned above. This biology active substance isolated from lymph can induct the symptoms of radiation syndrome without previously radiation when it is administrated intramuscularly or intravenously to healthy animals. Enzyme immune assay (EIA) allowed researchers to indicate the significant levels of different forms of SDR in peripheral blood of animals in first 24 hours after radiation. Indication of high level of SDR -1 allowed to forecast a fast development of cerebral form of acute radiation disease. Determination

Australian radiation therapists' perceptions of the determinants of fitness to practise; a mixed methods focus group study

International Nuclear Information System (INIS)

Wright, Caroline A.; Schneider, Michal E.; Jolly, Brian; Baird, Marilyn A.

2014-01-01

Background: There is a lack of clarity as to what factors affect practitioners' fitness to practise (FTP). Purpose: The purpose of this study was to identify what radiation therapists perceived to be the key determinants of FTP and to establish the importance that they place on each determinant. Methods: A mixed methods approach using focus groups with a brainstorming activity was used for data collection. Qualitative analysis was informed by grounded theory, where the data was coded and assigned themes. Findings: Three focus groups were conducted with 21 participants. Twenty-one unique determinants of FTP were identified. Professional development, communication, competence, qualifications, ethics and professionalism were common themes in all focus groups. Knowledge, technical and professional skills were most frequently cited by participants as the three most important determinants. Self-awareness, values and ethics featured last on the list. Participants of higher seniority identified a greater variety of determinants with lesser emphasis on technical skills, when compared with junior participants. Nine determinant themes were identified initially and these were spliced to form three primary categories; Impairment, Competence, and Values/Ethics. Conclusion: The most important issues to radiation therapists were associated with technical and clinical competence. This indicates a need to further educate practitioners on the other determinants of FTP, such as values, ethics, probity, trust and criminal activity. Further investigation is required to assess practitioner behavioural responses to deviations from accepted practice and the socio-cultural context of FTP

Radiation quality assurance intercomparison studies 1974--1975

International Nuclear Information System (INIS)

1975-10-01

The Quality Assurance Branch of the Monitoring Systems Research and Development Division at the U.S. Environmental Protection Agency's Environmental Monitoring and Support Laboratory-Las Vegas prepares and distributes calibrated low-level radioactive solutions to Federal, State, and private laboratories involved in environmental radiation monitoring and surveillance. These solutions are used for both the calibration of counting instruments and chemical yield determinations. Since the laboratories using these samples must have confidence in their accuracy, the Quality Assurance Branch has instituted intercomparison studies with the National Bureau of Standards and with the Energy Research and Development Administration Health and Service Laboratory. The results of the studies conducted during 1974 and 1975 are described

Students Union, University Administration and Political Development ...

African Journals Online (AJOL)

Students Union, University Administration and Political Development of Nations. ... African Research Review ... resting on the reciprocal determinism of the social learning theory, that students union makes university administration smooth.

Radiation exposure records management

International Nuclear Information System (INIS)

Boiter, H.P.

1975-12-01

Management of individual radiation exposure records begins at employment with the accumulation of data pertinent to the individual and any previous occupational radiation exposure. Appropriate radiation monitorinng badges or devices are issued and accountability established. A computer master file is initiated to include the individual's name, payroll number, social security number, birth date, assigned department, and location. From this base, a radiation exposure history is accumulated to include external ionizing radiation exposure to skin and whole body, contributing neutron exposure, contributing tritium exposure, and extremity exposure. It is used also to schedule bioassay sampling and in-vivo counts and to provide other pertinent information. The file is used as a basis for providing periodic reports to management and monthly exposure summaries to departmental line supervision to assist in planning work so that individual annual exposures are kept as low as practical. Radiation exposure records management also includes documentation of radiation surveys performed by the health physicist to establish working rates and the individual estimating and recording his estimated exposure on a day-to-day basis. Exposure information is also available to contribute to Energy Research and Development Administration statistics and to the National Transuranium Registry

Determination of gamma radiation lethal dose (LD50) and resveratrol cytotoxicity level in tumor cells line

International Nuclear Information System (INIS)

Magalhaes, Vanessa D.; Rogero, Sizue O.; Rogero, Jose R.; Cruz, Aurea S.

2011-01-01

Cancer is a disease with high incidence and it is considered a worldwide public health problem. Resveratrol is a polyphenol occurring naturally in a wide variety of plants according to response of ultraviolet radiation (UV) exposition or according to mechanical stress resulting of pathogens or chemical and physical agents. This polyphenol possesses a pharmacological activity of carcinogenesis inhibition in multiple levels. It also protects cells by scavenging the free radicals which are considered toxic products. These free radicals are formed of natural process of cell aging and also by incidence of ionizing radiation in the organism. Thus, resveratrol is considered as a cell radioprotector. On the other hand, in some elevated concentrations resveratrol may be considered as a radiosensitizing. The aim of this work was the determination of radiation lethal dose (LD 50 ) and also verifies the cytotoxicity level of resveratrol in tumor cells line: muco epidermoid pulmonary carcinoma cells (NCI-H292) and rhabdomyosarcoma cells (RD). The cytotoxicity test was performed by neutral red uptake assay. The results of resveratrol IC 50% in NCI-H292 cells was 192μM and in RD cells was 128μM; and RD cells gamma radiation LD 50 was 435Gy. (author)

Surprising radiation detectors

CERN Document Server

Fleischer, Robert

2003-01-01

Radiation doses received by the human body can be measured indirectly and retrospectively by counting the tracks left by particles in ordinary objects like pair of spectacles, glassware, compact disks...This method has been successfully applied to determine neutron radiation doses received 50 years ago on the Hiroshima site. Neutrons themselves do not leave tracks in bulk matter but glass contains atoms of uranium that may fission when hurt by a neutron, the recoil of the fission fragments generates a track that is detectable. The most difficult is to find adequate glass items and to evaluate the radiation shield they benefited at their initial place. The same method has been used to determine the radiation dose due to the pile-up of radon in houses. In that case the tracks left by alpha particles due to the radioactive decay of polonium-210 have been counted on the superficial layer of the window panes. Other materials like polycarbonate plastics have been used to determine the radiation dose due to heavy io...

1989 annual work report of the KFA Department for Safety and Radiation Protection

International Nuclear Information System (INIS)

Hille, R.; Frenkler, K.L.

1990-03-01

The Department for Safety and Radiation Protection continues to be responsible for coordinating radiation protection, safety and protection at the KFA. It supports the other institutes and departments in performing the safety tasks allotted to them. The principal tasks of the Department are in administrative and technical assistance to these organization units and in safeguards. Administrative assistance involves, for example, regulation of the radiation protection organization in the institutes, including the appointment of radiation protection officers (Strahlenschutzbeauftrage). Furthermore, this includes the central handling of the registration system with the authorities and dealing with outside firms thus considerably relieving the institutes of their administrative tasks. Handling licensing procedures and the central accountancy of radioactive materials is also to be mentioned in this context. Technical assistance largely consists of developing, maintaining and repairing radiation measuring instruments and in the monitoring of personnel by evaluating personnel dosimeters and incorporation controls for radioactive sources. The safeguards tasks of the Department concern the very staff-intensive physical protection, as well as environmental protection and industrial safety. (orig.) [de

Importance of the neutron spectrum for determination of radiation damage

International Nuclear Information System (INIS)

Hehn, G.; Stiller, P.; Mattes, M.

1977-01-01

Since the radiation effects of neutrons depend strongly on the neutron energy, the correlation between the induced damage and the fluence of the fast neutrons shows appreciable disadvantages. The measured values of changes in material properties resulted in large differences for the same fast neutron fluence, being partly due to different neutron spectra. The uncertainties in damage data led to strong overdesign of important structural components. Different neutron environment at surveillance sample position may give an underestimation of the embrittlement in the reactor pressure vessel, which has to be avoided. The application of damage functions combined with accurately calculated neutron spectra, promise to be a reasonable solution. The damage function has the advantage of a phenomenological quantity that all spectral effects are included. But the correlation quantity has to be determined of high experimental costs. Therefore approximations of its energy distributions are very important. For the keV energy region the kerma function is reasonably good. For the MeV energy region a higher effort is needed to calculate the displacement cross section. The same holds for the low energy part. In all three parts the formation of stable material property levels may vary, so that the final correlation can be determined only by measurements of material properties in different neutron spectra. In material samples the spectra distribution of the displacement production rate was determined at different local positions outside the reactor core of a PWR and a fast breeder showing the most important energy regions of both reactors. (orig.) [de

FDA's requirements for radiation dosimetry of radiopharmaceutical drug products

International Nuclear Information System (INIS)

Abel, N.M.

1986-01-01

The primary concern of the Office of Drug Research and Review of the Food and Drug Administration in the field of radiation dosimetry is to ensure that radiopharmaceutical drug products are safe when used as investigational drugs (INDs) and are both safe and effective when a new drug application (NDA) is approved. In order to accomplish this, the sponsor of either an IND or applicant in the case of NDA must provide information that clearly describes the radiation dose that a patient will receive from the administration of the drug. The submitted numerical estimates of the radiation dose should be based on an absorbed fraction method of radiation dose calculation, such as the system set forth by the Medical Internal Radiation Dose (MIRD) Committee of the Society of Nuclear Medicine or the system set forth by the International Commission on Radiological Protection (ICRP). This presentation will describe in detail the data that a sponsor of an IND needs to submit to satisfy the regulatory requirements. Examples will be given of common mistakes and omissions by sponsors in their presentation of data

DOE occupational radiation exposure. Report 1992--1994

International Nuclear Information System (INIS)

1997-01-01

The DOE Occupational Radiation Exposure Report, 1992-1994 reports occupational radiation exposures incurred by individuals at US Department of Energy (DOE) facilities from 1992 through 1994. This report includes occupational radiation exposure information for all DOE employees, contractors, subcontractors, and visitors. This information is analyzed and trended over time to provide a measure of the DOE's performance in protecting its workers from radiation. Occupational radiation exposure at DOE has been decreasing over the past 5 years. In particular, doses in the higher dose ranges are decreasing, including the number of doses in excess of the DOE limits and doses in excess of the 2 rem Administrative Control Level (ACL). This is an indication of greater attention being given to protecting these individuals from radiation in the workplace

Regulatory inspections in nuclear plants in the field of radiation protection

International Nuclear Information System (INIS)

Hort, M.; Fuchsova, D.

2014-01-01

State Office for Nuclear Safety executes state administration and performs inspections at peaceful use of nuclear energy and ionizing radiation in the field of radiation protection and nuclear safety. Inspections on radiation protection at nuclear power plants are secured by inspectors of the Department of Radiation Protection in Fuel Cycle, who work at the Regional centre Brno and Ceske Budejovice. (authors)

The State Institute for Radiation Hygiene

International Nuclear Information System (INIS)

Following diagrams showing the organisational structure of the Institute and its administrative relationships and a list of personnel, a history of the Institute is presented by its retiring director. A statistical survey of the radiation apparatus, plants and equipment inspected, of training courses held and of radiation doses to personnel under the Institute's surveillance follows. Finally a list of publications by staff members and membership of committees is given. (JIW)

Development of a concept for radiation patients exposure assessment during dental X-ray examinations and statistical data acquisition for the determination of a diagnostic reference value

International Nuclear Information System (INIS)

Kueppers, C.; Sering, M.; Poppe, B.; Poplawski, A.; Looe, H.K.; Beyer, D.; Pfaffenberger, A.; Chofor, N.; Eenboom, F.

2012-01-01

The research project on the development a concept for radiation patients exposure assessment during dental X-ray examinations and statistical data acquisition for the determination of a diagnostic reference value includes the following issues: Fundamental facts: dental X-ray examination techniques, dose relevant factors and characteristics during X-ray examinations, radiation exposed organs during dental X-ray examinations, dose assessment based on phantoms. Materials and methodologies of the project: TLD measurements using the phantom, calculation of the effective dose during dental X-ray examinations, properties and settings of the reference facilities for the determination of radiation exposure, selection of dental offices, dosimetric measurements, data acquisition and statistical evaluation. Results of dosimetric examinations: results of dosimetric measurements at reference facilities, results of dosimetric measurements in dental offices. Discussion of the concept for the determination of the radiation exposure during dental X-ray examinations.

Advisory Committee on human radiation experiments final report

International Nuclear Information System (INIS)

1995-10-01

When the Advisory Committee began work in April 1994 we were charged with determining whether the radiation experiments design and administration adequately met the ethical and scientific standards, including standards of informed consent, that prevailed at the time of the experiments and that exist today and also to determine the ethical and scientific standards and criteria by which it shall evaluate human radiation experiments. Although this charge seems straightforward, it is in fact difficult to determine what the appropriate standards should be for evaluating the conduct and policies of thirty or fifty years ago. First, we needed to determine the extent to which the standards of that time are similar to the standards of today. To the extent that there were differences we needed to determine the relative roles of each in making moral evaluations. In Chapter 1 we report what we have been able to reconstruct about government rules and policies in the 1940s and 1950s regarding human experiments. We focus primarily on the Atomic Energy Commission and the Department of Defense. In Chapter 2 we turn from a consideration of government standards to an exploration of the norms and practices of physicians and medical scientists who conducted research with human subjects during this period. Using the results of our Ethics Oral History Project, and other sources, we also examine how scientists of the time viewed their moral responsibilities to human subjects as well as how this translated into the manner in which they conducted their research

Advisory Committee on human radiation experiments final report

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-10-01

When the Advisory Committee began work in April 1994 we were charged with determining whether the radiation experiments design and administration adequately met the ethical and scientific standards, including standards of informed consent, that prevailed at the time of the experiments and that exist today and also to determine the ethical and scientific standards and criteria by which it shall evaluate human radiation experiments. Although this charge seems straightforward, it is in fact difficult to determine what the appropriate standards should be for evaluating the conduct and policies of thirty or fifty years ago. First, we needed to determine the extent to which the standards of that time are similar to the standards of today. To the extent that there were differences we needed to determine the relative roles of each in making moral evaluations. In Chapter 1 we report what we have been able to reconstruct about government rules and policies in the 1940s and 1950s regarding human experiments. We focus primarily on the Atomic Energy Commission and the Department of Defense. In Chapter 2 we turn from a consideration of government standards to an exploration of the norms and practices of physicians and medical scientists who conducted research with human subjects during this period. Using the results of our Ethics Oral History Project, and other sources, we also examine how scientists of the time viewed their moral responsibilities to human subjects as well as how this translated into the manner in which they conducted their research.

Market failure as ignored determinant of the choice between public and business administration

Directory of Open Access Journals (Sweden)

Gaylord George Candler

Full Text Available Abstract In the epistemology of administrative science, one of many important dimensions has been the different subfields of the study of administration. Perhaps the biggest, longest running ‘turf’ battle between these different areas of administrative knowledge is that between public and business administration. This is a controversy that goes back at least to Adam Smith, with his specific limitation of the role of ‘the sovereign’ (government, or public administration to justice, defense, and public works. In limiting government to these areas, note that Smith was also implicitly asserting that these were market, or ‘invisible hand’ failures: areas where the pursuit of self-interest would not yield the good of society, the specific moral justification Smith identified for market exchange. Contemporary discussions of the relative role of market and state are generally framed in terms of the role of the State, with market provision the default option. We will argue that even discussions of the role of the State can best be assessed through the concept of market failure. The nine broad types of market failure discussed include institutions, public goods, monopoly, asymmetric information, externalities, substantive issues, principal/agent problems, irrationality, and the implications of ‘creative destruction’.

GENERAL CHANGES AS A CONDITION OF INCREASING THE EFFICIENCY OF PUBLIC ADMINISTRATION - THE CASE OF THE TAX ADMINISTRATION

OpenAIRE

Hak, Mario; Budić, Hrvoje; Pišmiš, Vjekoslav

2016-01-01

Efficiency has long played a central role in the contested terrain of public administration values. This paper analyzes the existing business processes and explores how to determine the optimal model of business processes in the Tax Administration. The goal of this model of bussines is to increase business efficiency and reflecting on all users of the Tax Administration.

Space Station Validation of Advanced Radiation-Shielding Polymeric Materials, Phase II

Data.gov (United States)

National Aeronautics and Space Administration — In Subtopic X11.01, NASA has identified the need to develop advanced radiation-shielding materials and systems to protect humans from the hazards of space radiation...

Radiation safety and care of patients

International Nuclear Information System (INIS)

Das, B.K.; Noreen Norfaraheen Lee Abdullah

2012-01-01

The objective of this chapter is to acquaint the reader with radiation safety measures which can be pursued to minimize radiation load to the patient and staff. The basic principle is that all unnecessary administration should be avoided and a number of simple techniques be used to reduce radiation dose. For example, the kidney excretes many radionuclides. Drinking plenty of fluid and frequent bladder emptying can minimize absorbed dose to the bladder. Thyroid blocking agents must be used if radioactive iodine is being administered to avoid unnecessary radiation exposure to the thyroid gland. When it is necessary to administer radioactive substances to a female of childbearing age, the radiation exposure should be minimum and information whether the patient is pregnant or not must be obtained. Alternatives techniques, which do not involve ionizing radiation, should also be considered. (author)

Radiation protection for the illegal governmental use of radiation sources. A case study

International Nuclear Information System (INIS)

Becker, K.

2000-01-01

Probably for the first time, illegal governmental uses of radiation sources, including the administrative infrastructure such as special radiation protection regulation, an advisory body etc., have been documented by the evaluation of the documents of the Ministry of State Security in the former German Democratic Republic (East Germany). Over a thousand persons, but also documents, money bills etc. were marked with a wide variety of radionuclides and traced with specially developed detectors. Among the many different nuclides provided regularly from the Rossendorf Research Center near Dresden, in particular 46 Sc was popular. (orig.) [de

Space Radiation Intelligence System (SPRINTS), Phase I

Data.gov (United States)

National Aeronautics and Space Administration — NextGen Federal Systems proposes an innovative SPace Radiation INTelligence System (SPRINTS) which provides an interactive and web-delivered capability that...

Spatio-temporal coherence of free-electron laser radiation in the extreme ultraviolet determined by a Michelson interferometer

Energy Technology Data Exchange (ETDEWEB)

Hilbert, V.; Rödel, C.; Zastrau, U., E-mail: ulf.zastrau@uni-jena.de [Institut für Optik und Quantenelektronik, Friedrich-Schiller-Universität, Max-Wien-Platz 1, 07743 Jena (Germany); Brenner, G.; Düsterer, S.; Dziarzhytski, S.; Harmand, M.; Przystawik, A.; Redlin, H.; Toleikis, S. [Deutsches Elektronen-Synchrotron DESY, Notkestrasse 85, 22607 Hamburg (Germany); Döppner, T.; Ma, T. [Lawrence Livermore National Laboratory, 7000 East Avenue, Livermore, California 94550 (United States); Fletcher, L. [Department of Physics, University of California, Berkeley, California 94720 (United States); Förster, E. [Institut für Optik und Quantenelektronik, Friedrich-Schiller-Universität, Max-Wien-Platz 1, 07743 Jena (Germany); Helmholtz-Institut Jena, Fröbelstieg 3, 07743 Jena (Germany); Glenzer, S. H.; Lee, H. J. [SLAC National Accelerator Laboratory, 2575 Sand Hill Road, Menlo Park, California 94025 (United States); Hartley, N. J. [Department of Physics, Clarendon Laboratory, University of Oxford, Parks Road, Oxford OX1 3PU (United Kingdom); Kazak, L.; Komar, D.; Skruszewicz, S. [Institut für Physik, Universität Rostock, 18051 Rostock (Germany); and others

2014-09-08

A key feature of extreme ultraviolet (XUV) radiation from free-electron lasers (FELs) is its spatial and temporal coherence. We measured the spatio-temporal coherence properties of monochromatized FEL pulses at 13.5 nm using a Michelson interferometer. A temporal coherence time of (59±8) fs has been determined, which is in good agreement with the spectral bandwidth given by the monochromator. Moreover, the spatial coherence in vertical direction amounts to about 15% of the beam diameter and about 12% in horizontal direction. The feasibility of measuring spatio-temporal coherence properties of XUV FEL radiation using interferometric techniques advances machine operation and experimental studies significantly.

Radiation decontamination unit for the community hospital

International Nuclear Information System (INIS)

Waldron, R.L. II; Danielson, R.A.; Shultz, H.E.; Eckert, D.E.; Hendricks, K.O.

1981-01-01

Freestanding radiation decontamination units including surgical capability can be developed and made operational in small/medium sized community hospitals at relatively small cost and with minimal plant reconstrution. The Radiological Assistance Program of the United States Department of Energy and the Radiation Emergency Assistance Center Training Site of Oak Rige Associated Universities are ready to support individual hospitals and physicians in this endeavor. Adequate planning rather than luck, should be used in dealing with potential radiation accident victims. The radiation emergency team is headed by a physician on duty in the hospital. The senior administrative person on duty is responsible for intramural and extramural communications. Rapid mobilization of the radiation decontamination unit is important

A Reinforcement for Multifunctional Composites for Non-Parasitic Radiation Shielding, Phase II

Data.gov (United States)

National Aeronautics and Space Administration — Radiation shielding is a requirement to protect humans from the hazards of space radiation during NASA missions. Multifunctional materials have the potential to...

Measurement of continuous x-radiation and determination of the energy distribution function of high-energy electrons from an ECR plasma

International Nuclear Information System (INIS)

Bernhardi, K.

1980-01-01

Investigations were made on the x-radiation emitted by a plasma. The methods applied here represent a further development of experimental and numerical methods used hitherto for determining the bremsstrahlung emitted by a plasma, and makes possible a more precise determination of the high-energy electron component of a plasma

Determination of the radiative decay width of the positive K*+(890) meson

International Nuclear Information System (INIS)

Chandlee, C.D.

1983-01-01

A systematic study of the coherent excitation of high energy pions and kaons by nuclear targets has been completed at Fermilab (Experiment 272) with the intent of extracting the radiative decay widths of the various vector and tensor mesons. This work was initiated to furnish experimental results for comparison with theoretical predictions based on unitary symmetry schemes, quark models, and vector dominance models with the hope of shedding light on the structure of the quark-antiquark system. The work presented here deals with data collected during the second running period of E272 on the excitation of incident 200 GeV/c K + by copper and lead targets for the purpose of precisely determining the radiative width from the transition K* + (890) → K + γ. The experiment was performed in the MIE secondary beam line of the Meson Lab utilizing an enhanced, Cherenkov tagged, positive kaon beam, a forward charged particle spectrometer consisting of drift and proportional wire chambers, and a liquid argon colorimeter for photon detection. A Primakoff type analysis of excitation in the nuclear Coulomb field including a strong contribution to the coherent production process from isoscalar exchange was applied to data for both the K + π 0 and K/sub S/ 0 π + decay modes of the K* +

Design Methodologies and to Combat Radiation Induced Corruption in FPGAs and SoCs, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — Traditional radiation hardened by process (RHBP) and radiation hardened by design (RHBD) techniques have seen success in mitigating the effects of radiation induced...

Determination of daily solar ultraviolet radiation using statistical models and artificial neural networks

Directory of Open Access Journals (Sweden)

F. J. Barbero

2006-09-01

Full Text Available In this study, two different methodologies are used to develop two models for estimating daily solar UV radiation. The first is based on traditional statistical techniques whereas the second is based on artificial neural network methods. Both models use daily solar global broadband radiation as the only measured input. The statistical model is derived from a relationship between the daily UV and the global clearness indices but modulated by the relative optical air mass. The inputs to the neural network model were determined from a large number of radiometric and atmospheric parameters using the automatic relevance determination method, although only the daily solar global irradiation, daily global clearness index and relative optical air mass were shown to be the optimal input variables. Both statistical and neural network models were developed using data measured at Almería (Spain, a semiarid and coastal climate, and tested against data from Table Mountain (Golden, CO, USA, a mountainous and dry environment. Results show that the statistical model performs adequately in both sites for all weather conditions, especially when only snow-free days at Golden were considered (RMSE=4.6%, MBE= –0.1%. The neural network based model provides the best overall estimates in the site where it has been trained, but presents an inadequate performance for the Golden site when snow-covered days are included (RMSE=6.5%, MBE= –3.0%. This result confirms that the neural network model does not adequately respond on those ranges of the input parameters which were not used for its development.

NEITHER FISH NOR FOWL: ADMINISTRATIVE JUDGES IN THE MODERN ADMINISTRATIVE STATE

Directory of Open Access Journals (Sweden)

Russell L. Weaver

2010-10-01

Full Text Available This article examines the role of administrative adjudication in the United States constitutional system. It begins by noting that such adjudication fits uncomfortably within a system of divided powers. Administrative judges, including administrative law judges [ALJs] (who have the highest level of protection and status, are considerably more circumscribed than ordinary Article III judges. Indeed, administrative judges are usually housed in the agencies for which they decide cases, rather than in independent adjudicative bodies, and they do not always have the final say regarding the cases they decide. In many instances, the agency can appeal an adverse administrative judge’s decision directly to the head of the agency, and the agency head retains broad power to overrule the administrative judge’s determinations. In other words, the agency can substitute its judgment for that of the administrative judge regarding factual determinations, legal determinations, and policy choices. As a result, many administrative adjudicative structures involve difficult tradeoffs between independence, political control, and accountability. This article examines issues related to the status and power of administrative judges, as well as the constraints that have been imposed on administrative adjudicative authority, and explores whether those constraints continue to serve the purposes for which they were originally imposed. Cet article examine le rôle du règlement de différends dans le domaine administratif dans le cadre du système constitutionnel des États-Unis. Il note d’abord qu’une telle façon de régler les différends cadre difficilement avec un système où les pouvoirs sont divisés. Les juges administratifs, y inclus les juges de droit administratif (qui jouissent du niveau le plus élevé de protection et de statut, sont considérablement plus restreints que les juges ordinaires sous l’Article III. En effet, les juges administratifs sont

The impact of selected organizational variables and managerial leadership on radiation therapists' organizational commitment

International Nuclear Information System (INIS)

Akroyd, Duane; Legg, Jeff; Jackowski, Melissa B.; Adams, Robert D.

2009-01-01

The purpose of this study was to examine the impact of selected organizational factors and the leadership behavior of supervisors on radiation therapists' commitment to their organizations. The population for this study consists of all full time clinical radiation therapists registered by the American Registry of Radiologic Technologists (ARRT) in the United States. A random sample of 800 radiation therapists was obtained from the ARRT for this study. Questionnaires were mailed to all participants and measured organizational variables; managerial leadership variable and three components of organizational commitment (affective, continuance and normative). It was determined that organizational support, and leadership behavior of supervisors each had a significant and positive affect on normative and affective commitment of radiation therapists and each of the models predicted over 40% of the variance in radiation therapists organizational commitment. This study examined radiation therapists' commitment to their organizations and found that affective (emotional attachment to the organization) and normative (feelings of obligation to the organization) commitments were more important than continuance commitment (awareness of the costs of leaving the organization). This study can help radiation oncology administrators and physicians to understand the values their radiation therapy employees hold that are predictive of their commitment to the organization. A crucial result of the study is the importance of the perceived support of the organization and the leadership skills of managers/supervisors on radiation therapists' commitment to the organization.

Interaction of hyperthermia and radiation: radiation quality

International Nuclear Information System (INIS)

Loshek, D.D.; Orr, J.S.; Solomonidis, E.

1981-01-01

Cell-survival data were collected to determine the survival response of asynchronous CHO cells subject to radiation and hyperthermia. The irradiation was at room temperature 100 minutes before exposure to hyperthermia at 42 0 C. The survival response to the combination of these two agents is expressed by means of a survival surface, a three-dimensional concept relating cell survival to heat dose and radiation dose. The survival surface could be approximately described by a survival model comprising three components of cell killing: the unperturbed radiation component, the unperturbed hyperthermia component and the interaction component. The dependence of the radiation component and the interaction component on radiation quality were investigated by irradiating with either 60 Co γ rays, 250 kV X rays or 14.7 MeV neutrons. An analysis suggests that the interaction component and the radiation component exhibit similar dependencies on radiation quality both for the deposition of damage and the repair or accumulation of that damage. (U.K.)

Determinants of Patient Satisfaction During Receipt of Radiation Therapy

International Nuclear Information System (INIS)

Famiglietti, Robin M.; Neal, Emily C.; Edwards, Timothy J.; Allen, Pamela K.; Buchholz, Thomas A.

2013-01-01

Purpose: To evaluate the correlations and relative contributions of components of a radiation oncology-specific patient satisfaction survey to their overall satisfaction scores. Methods and Materials: From September 2006 through August 2012, we prospectively collected data from 8069 patients receiving radiation treatments with a 26-question survey. Each question was rated on a 10-point Likert scale. We analyzed the correlation between scores for each question and the overall satisfaction question. We also dichotomized the scores to reflect satisfaction versus dissatisfaction and used logistic regression to assess the relationship between items in 4 domains (the patient–provider relationship, access and environmental issues, wait times, and educational information) and overall satisfaction. Results: Scores on all questions correlated with overall patient satisfaction scores (P 2 =0.4219), followed by wait times (R 2 =0.4000), access/environment (R 2 =0.3837), and patient education (R 2 =0.3700). The specific variables with the greatest effect on patient satisfaction were the care provided by radiation therapists (odds ratio 1.91) and pain management (odds ratio 1.29). Conclusions: We found that patients' judgment of provider relationships in an outpatient radiation oncology setting were the greatest contributors to their overall satisfaction ratings. Other measures typically associated with patient satisfaction (phone access, scheduling, and ease of the check-in process) correlated less strongly with overall satisfaction. These findings may be useful for other practices preparing to assess patient ratings of quality of care

Ionizing radiation

Science.gov (United States)

Tobias, C. A.; Grigoryev, Y. G.

1975-01-01

The biological effects of ionizing radiation encountered in space are considered. Biological experiments conducted in space and some experiences of astronauts during space flight are described. The effects of various levels of radiation exposure and the determination of permissible dosages are discussed.

Determining lethal dose of gamma radiation on different stages of Tribolium Cosmonauts H b s t

International Nuclear Information System (INIS)

Zolfagharieh, H.R.; Majd, F.; Torshyzie, M.; Babaie, M.

1992-10-01

Pest infestation causes great losses to stored grain through out the world. This is specially true in developing countries where the technology is less advanced, and climatic conditions are extremely favourable for the development of pests. Irradiation is on approved method of direct control for stored-product insect in wheat and wheat flour in many countries, and in dictation are that it will soon be approved for all grain, grain products and other dry food commodities. Radiation doses required to kill or sterilized the most important storage pests in all stages are known. However irradiation is very effective in preventing insect development and in producing sterility. A detailed analysis of the radiosensitivity of stored-product insects shows the different groups of pests have very different sensitivities and quarantine doses can be tailored to kill or sterilize the species of quarantine concern. The effect of irradiation on insects are many, and varied, depending primarily on the species, stage, age and physical factors. The aim is to survey the effect of gamma radiation on stored pest, which can categorized under following classes: 1-The effect of gamma radiation on different stages grow of tribolium castaneum (H B S T); 2-Determination of lethal doses.; 3-The study of gamma radiation on products. In summary these information indicated that fairly low dosages of gamma radiation could be used on commodities such as bulk grain in which some infestation by insect stages of irradiation would be required on products such package foods where hundred percent mortality must be obtain. (author)

Radiation-Induced Rib Fractures After Hypofractionated Stereotactic Body Radiation Therapy: Risk Factors and Dose-Volume Relationship

Energy Technology Data Exchange (ETDEWEB)

Asai, Kaori [Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan); Shioyama, Yoshiyuki, E-mail: shioyama@radiol.med.kyushu-u.ac.jp [Department of Heavy Particle Therapy and Radiation Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan); Nakamura, Katsumasa; Sasaki, Tomonari; Ohga, Saiji; Nonoshita, Takeshi [Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan); Yoshitake, Tadamasa [Department of Heavy Particle Therapy and Radiation Oncology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan); Ohnishi, Kayoko [Department of Radiology, National Center for Global Health and Medicine, Tokyo (Japan); Terashima, Kotaro; Matsumoto, Keiji [Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan); Hirata, Hideki [Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan); Honda, Hiroshi [Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, Fukuoka (Japan)

2012-11-01

Purpose: The purpose of this study was to clarify the incidence, the clinical risk factors, and the dose-volume relationship of radiation-induced rib fracture (RIRF) after hypofractionated stereotactic body radiation therapy (SBRT). Methods and Materials: One hundred sixteen patients treated with SBRT for primary or metastatic lung cancer at our institution, with at least 6 months of follow-up and no previous overlapping radiation exposure, were included in this study. To determine the clinical risk factors associated with RIRF, correlations between the incidence of RIRF and the variables, including age, sex, diagnosis, gross tumor volume diameter, rib-tumor distance, and use of steroid administration, were analyzed. Dose-volume histogram analysis was also conducted. Regarding the maximum dose, V10, V20, V30, and V40 of the rib, and the incidences of RIRF were compared between the two groups divided by the cutoff value determined by the receiver operating characteristic curves. Results: One hundred sixteen patients and 374 ribs met the inclusion criteria. Among the 116 patients, 28 patients (46 ribs) experienced RIRF. The estimated incidence of rib fracture was 37.7% at 3 years. Limited distance from the rib to the tumor (<2.0 cm) was the only significant risk factor for RIRF (p = 0.0001). Among the dosimetric parameters used for receiver operating characteristic analysis, the maximum dose showed the highest area under the curve. The 3-year estimated risk of RIRF and the determined cutoff value were 45.8% vs. 1.4% (maximum dose, {>=}42.4 Gy or less), 51.6% vs. 2.0% (V40, {>=}0.29 cm{sup 3} or less), 45.8% vs. 2.2% (V30, {>=}1.35 cm{sup 3} or less), 42.0% vs. 8.5% (V20, {>=}3.62 cm{sup 3} or less), or 25.9% vs. 10.5% (V10, {>=}5.03 cm{sup 3} or less). Conclusions: The incidence of RIRF after hypofractionated SBRT is relatively high. The maximum dose and high-dose volume are strongly correlated with RIRF.

An Assessment of the Current US Radiation Oncology Workforce: Methodology and Global Results of the American Society for Radiation Oncology 2012 Workforce Study

Energy Technology Data Exchange (ETDEWEB)

Vichare, Anushree; Washington, Raynard; Patton, Caroline; Arnone, Anna [ASTRO, Fairfax, Virginia (United States); Olsen, Christine [Massachusetts General Hospital, Boston, Massachusetts, (United States); Fung, Claire Y. [Commonwealth Newburyport Cancer Center, Newburyport, Massachusetts (United States); Hopkins, Shane [William R. Bliss Cancer Center, Ames, Iowa (United States); Pohar, Surjeet, E-mail: spohar@netzero.net [Indiana University Health Cancer Center East, Indiana University, Indianapolis, Indiana (United States)

2013-12-01

Purpose: To determine the characteristics, needs, and concerns of the current radiation oncology workforce, evaluate best practices and opportunities for improving quality and safety, and assess what we can predict about the future workforce. Methods and Materials: An online survey was distributed to 35,204 respondents from all segments of the radiation oncology workforce, including radiation oncologists, residents, medical dosimetrists, radiation therapists, medical physicists, nurse practitioners, nurses, physician assistants, and practice managers/administrators. The survey was disseminated by the American Society for Radiation Oncology (ASTRO) together with specialty societies representing other workforce segments. An overview of the methods and global results is presented in this paper. Results: A total of 6765 completed surveys were received, a response rate of 19%, and the final analysis included 5257 respondents. Three-quarters of the radiation oncologists, residents, and physicists who responded were male, in contrast to the other segments in which two-thirds or more were female. The majority of respondents (58%) indicated they were hospital-based, whereas 40% practiced in a free-standing/satellite clinic and 2% in another setting. Among the practices represented in the survey, 21.5% were academic, 25.2% were hospital, and 53.3% were private. A perceived oversupply of professionals relative to demand was reported by the physicist, dosimetrist, and radiation therapist segments. An undersupply was perceived by physician's assistants, nurse practitioners, and nurses. The supply of radiation oncologists and residents was considered balanced. Conclusions: This survey was unique as it attempted to comprehensively assess the radiation oncology workforce by directly surveying each segment. The results suggest there is potential to improve the diversity of the workforce and optimize the supply of the workforce segments. The survey also provides a benchmark for

An Assessment of the Current US Radiation Oncology Workforce: Methodology and Global Results of the American Society for Radiation Oncology 2012 Workforce Study

International Nuclear Information System (INIS)

Vichare, Anushree; Washington, Raynard; Patton, Caroline; Arnone, Anna; Olsen, Christine; Fung, Claire Y.; Hopkins, Shane; Pohar, Surjeet

2013-01-01

Purpose: To determine the characteristics, needs, and concerns of the current radiation oncology workforce, evaluate best practices and opportunities for improving quality and safety, and assess what we can predict about the future workforce. Methods and Materials: An online survey was distributed to 35,204 respondents from all segments of the radiation oncology workforce, including radiation oncologists, residents, medical dosimetrists, radiation therapists, medical physicists, nurse practitioners, nurses, physician assistants, and practice managers/administrators. The survey was disseminated by the American Society for Radiation Oncology (ASTRO) together with specialty societies representing other workforce segments. An overview of the methods and global results is presented in this paper. Results: A total of 6765 completed surveys were received, a response rate of 19%, and the final analysis included 5257 respondents. Three-quarters of the radiation oncologists, residents, and physicists who responded were male, in contrast to the other segments in which two-thirds or more were female. The majority of respondents (58%) indicated they were hospital-based, whereas 40% practiced in a free-standing/satellite clinic and 2% in another setting. Among the practices represented in the survey, 21.5% were academic, 25.2% were hospital, and 53.3% were private. A perceived oversupply of professionals relative to demand was reported by the physicist, dosimetrist, and radiation therapist segments. An undersupply was perceived by physician's assistants, nurse practitioners, and nurses. The supply of radiation oncologists and residents was considered balanced. Conclusions: This survey was unique as it attempted to comprehensively assess the radiation oncology workforce by directly surveying each segment. The results suggest there is potential to improve the diversity of the workforce and optimize the supply of the workforce segments. The survey also provides a benchmark for

A new algorithm to determine the total radiated power at ASDEX upgrade

Energy Technology Data Exchange (ETDEWEB)

Gloeggler, Stephan; Bernert, Matthias; Eich, Thomas [Max Planck Institute for Plasma Physics, Boltzmannstr. 2, 85748 Garching (Germany); Collaboration: The ASDEX Upgrade Team

2016-07-01

Radiation is an essential part of the power balance in a fusion plasma. In future fusion devices about 90% of the power will have to be dissipated, mainly by radiation. For the development of an appropriate operational scenario, information about the absolute level of plasma radiation (P{sub rad,tot}) is crucial. Bolometers are used to measure the radiated power, however, an algorithm is required to derive the absolute power out of many line-integrated measurements. The currently used algorithm (BPD) was developed for the main chamber radiation. It underestimates the divertor radiation as its basic assumptions are not satisfied in this region. Therefore, a new P{sub rad,tot} algorithm is presented. It applies an Abel inversion on the main chamber and uses empirically based assumptions for poloidal asymmetries and the divertor radiation. To benchmark the new algorithm, synthetic emissivity profiles are used. On average, the new Abel inversion based algorithm deviates by only 10% from the nominal synthetic value while BPD is about 25% too low. With both codes time traces of ASDEX Upgrade discharges are calculated. The analysis of these time traces shows that the underestimation of the divertor radiation can have significant consequences on the accuracy of BPD while the new algorithm is shown to be stable.

Administrative Strategies of Departmental Heads as Determinants for the Effective Management of Human Resources in Tertiary Institutions in Delta State, Nigeria

Science.gov (United States)

Osakwe, Regina N.

2015-01-01

This study investigated administrative strategies of departmental heads as determinants of effective management of human resources in tertiary institutions. Four research questions were asked and four hypotheses were formulated to guide the study. As a descriptive survey, the population comprised all the eight tertiary institutions in the state…

Role of neurotensin in radiation-induced hypothermia in rats

International Nuclear Information System (INIS)

Kandasamy, S.B.; Hunt, W.A.; Harris, A.H.

1991-01-01

The role of neurotensin in radiation-induced hypothermia was examined. Intracerebroventricular (ICV) administration of neurotensin produced dose-dependent hypothermia. Histamine appears to mediate neurotensin-induced hypothermia because the mast cell stabilizer disodium cromoglycate and antihistamines blocked the hypothermic effects of neurotensin. An ICV pretreatment with neurotensin antibody attenuated neurotensin-induced hypothermia, but did not attenuate radiation-induced hypothermia, suggesting that radiation-induced hypothermia was not mediated by neurotensin

DOE occupational radiation exposure. Report 1992--1994

Energy Technology Data Exchange (ETDEWEB)

NONE

1997-05-01

The DOE Occupational Radiation Exposure Report, 1992-1994 reports occupational radiation exposures incurred by individuals at US Department of Energy (DOE) facilities from 1992 through 1994. This report includes occupational radiation exposure information for all DOE employees, contractors, subcontractors, and visitors. This information is analyzed and trended over time to provide a measure of the DOE`s performance in protecting its workers from radiation. Occupational radiation exposure at DOE has been decreasing over the past 5 years. In particular, doses in the higher dose ranges are decreasing, including the number of doses in excess of the DOE limits and doses in excess of the 2 rem Administrative Control Level (ACL). This is an indication of greater attention being given to protecting these individuals from radiation in the workplace.

Determination of alpha constant value for brazilian reality aiming de radiation protection optimization

International Nuclear Information System (INIS)

Teixeira, Pedro Barbosa

2003-01-01

This work aims to present a methodology for the calculation of the alpha constant taking into account the actual conditions in Brazil. This constant is used for the minimization of the worker doses meaning the optimization of radiation protection. The alpha constant represents a monetary value to establish the health detriment associated to the stochastic effects for unit of collective dose, and is directly related to the value of the human life. Along the years, several methods have been developed to obtain the most appropriate value for the alpha constant. These methods will be objects of analysis of this work. This work presents two methods for determination of the alpha constant: 'human capital' that is based on GDP of the country and 'willingness-to-pay' that is established for the value that the population would be willing to pay for the safety of the nuclear and radioactive facilities. A new methodology for the calculation of the alpha constant has been proposed in this study, that is the combination of two method previously mentioned, and recommends a new value of US$ 16,000.00 per man-sievert. Currently the value established by CNEN is US$ 10,000.00 per men sievert. This work also presents, in full details, the main mathematical tools for the elaboration of the optimization of the radiation protection: cost-benefit analysis, extended cost-benefit analysis and multi attribute utility analysis. An applied example, for an uranium mine radiation protection optimization was used to compare those two values of the alpha constant. (author)

Improving patient safety in radiation oncology

International Nuclear Information System (INIS)

Hendee, William R.; Herman, Michael G.

2011-01-01

Beginning in the 1990s, and emphasized in 2000 with the release of an Institute of Medicine report, healthcare providers and institutions have dedicated time and resources to reducing errors that impact the safety and well-being of patients. But in January 2010 the first of a series of articles appeared in the New York Times that described errors in radiation oncology that grievously impacted patients. In response, the American Association of Physicists in Medicine and the American Society of Radiation Oncology sponsored a working meeting entitled ''Safety in Radiation Therapy: A Call to Action''. The meeting attracted 400 attendees, including medical physicists, radiation oncologists, medical dosimetrists, radiation therapists, hospital administrators, regulators, and representatives of equipment manufacturers. The meeting was cohosted by 14 organizations in the United States and Canada. The meeting yielded 20 recommendations that provide a pathway to reducing errors and improving patient safety in radiation therapy facilities everywhere.

Raphide crystal structure in agave tequilana determined by x-ray originating from synchrotron radiation

International Nuclear Information System (INIS)

Tadokoro, Makoto; Ozawa, Yoshiki; Mitsumi, Minoru; Toriumi, Kohshiro; Ogura, Tetsuya

2005-01-01

The first single crystal structure of small natural raphides in an agave plant is completely determined using an intense X-ray originating from a synchrotron radiation. The SEM image shows that the tip of the crystal is approximately hundreds of nanometer in width sharply grow to stick to the tissue of herbivorous vermin. Furthermore, the crystal develops cracks that propagate at an inclination of approximately 45deg towards the direction of crystal growth such that the crystal easily splits into small pieces in the tissue. (author)

In situ quantitative determination of transuranic elements in areas of high-level gamma radiation

International Nuclear Information System (INIS)

Brodzinski, R.L.; Wogman, N.A.

1978-01-01

A technique is described for passive neutron monitoring of transuranic elements. The method provides quantitative determinations of transuranic element concentrations in a variety of field situations where no other measurement method is possible. The technique can measure concentrations of transuranic oxides as low as 8 nCi/cm 3 and is capable of operating in gamma radiation fields up to megarads per hour. Information on chemical and isotopic composition can also be obtained from the data. Several successful applications of the technique are discussed

In situ quantitative determination of transuranic elements in areas of high-level gamma radiation

International Nuclear Information System (INIS)

Brodzinski, R.L.; Wogman, N.A.

1978-01-01

A technique is described for passive neutron monitoring of transuranic elements. The method provides quantitative determinations of transuranic element concentrations in a variety of field situations where no other measurement method is possible. The technique can measure concentrations of transuranic oxides as low as 8 nCi/cmsup 3 and is capable of operating in gamma radiation fields up to megarads per hour. Information on chemical and isotopic composition can also be obtained from the data. Several successful applications of the technique are discussed. 1 ref

LC determination and pharmacokinetic study of the main phenolic components of Portulaca oleracea L. extract in rat plasma after oral administration.

Science.gov (United States)

Cheng, Zhongzhe; Wang, Dong; Zhang, Wenjie; Du, Yang; Wang, Yunjiao; Zhai, Yanjun; Ying, Xixiang; Kang, Tingguo

2012-01-01

This study investigated the pharmacokinetics of hesperidin (HP), ferulic acid (FA) and p-coumaric acid (CA) in rat plasma after oral administration of Portulaca oleracea L. extract (POE). The plasma concentrations were determined by HPLC with vitexin-2″-O-rhamnoside (VR) as internal standard. The calibration curves were linear over the range 0.1-5 µg mL(-1), 0.1-5 µg mL(-1)and 0.015-3 µg mL(-1) for HP, FA and CA, respectively. The validated method was suitable to the pharmacokinetic study of HP, FA and CA in rats after oral administration at a single dose of POE.

Novel Radiation Protection System Enabled by Hydrogen Enhanced Nano Fibers, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — The need for radiation protection in humans is critical to the success of the nation's continued presence in space. A new radiation protection system will be...

Efficiency and attenuation correction factors determination in gamma spectrometric assay of bulk samples using self radiation

International Nuclear Information System (INIS)

Haddad, Kh.

2009-02-01

Gamma spectrometry forms the most important and capable tool for measuring radioactive materials. Determination of the efficiency and attenuation correction factors is the most tedious problem in the gamma spectrometric assay of bulk samples. A new experimental and easy method for these correction factors determination using self radiation was proposed in this work. An experimental study of the correlation between self attenuation correction factor and sample thickness and its practical application was also introduced. The work was performed on NORM and uranyl nitrate bulk sample. The results of proposed methods agreed with those of traditional ones.(author)

Effect Of Oligomeric Enteral Nutrition On Symptoms Of Acute Radiation Enteritis

International Nuclear Information System (INIS)

Dubinsky, P.

2008-01-01

Radiotherapy of abdominal and pelvic tumours is frequently associated with acute radiation enteritis. Predominant symptoms include diarrhea, watery stools, abdominal pain, nausea and vomiting. There are very few effective interventions available for this condition. Enteral oligomeric nutrition has been used in bowel diseases with functional failure similar to radiation enteritis. The aim of presented work was to observe occurrence of symptoms of radiation enteritis in patients undergoing abdominal or pelvic radiotherapy. Apart from diet and pharmacological therapy, oral oligomeric enteral nutrition (Peptisorb Powder Nutricia) at the dose of 1000 - 2000 ml per day was administered for minimum of 4 days. Planned period of administration was 14 days and longer. Symptoms of radiation enteritis were evaluated at the beginning and in the end of administration. Prevalence of all evaluated symptoms of radiation enteritis was decreased and difference was statistically significant for diarrhea, watery stools, abdominal pain, nausea and vomiting. The use of evaluated oligomeric nutritional support might, in conjunction with pharmacotherapy and diet, alleviate symptoms of acute radiation enteritis and maintain nutritional status of patients. (author)

Group: radiation dosimetry

International Nuclear Information System (INIS)

Caldas, L.V.E.

1990-01-01

The main activities of the radiation dosimetry group is described, including the calibration of instruments, sources and radioactive solutions and the determination of neutron flux; development, production and market dosimetric materials; development radiation sensor make the control of radiation dose received by IPEN workers; development new techniques for monitoring, etc. (C.G.C.)

21 CFR 892.5710 - Radiation therapy beam-shaping block.

Science.gov (United States)

2010-04-01

... 21 Food and Drugs 8 2010-04-01 2010-04-01 false Radiation therapy beam-shaping block. 892.5710 Section 892.5710 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES... block. (a) Identification. A radiation therapy beam-shaping block is a device made of a highly...

Photoelectric-enhanced radiation therapy with quasi-monochromatic computed tomography.

Science.gov (United States)

Jost, Gregor; Mensing, Tristan; Golfier, Sven; Lawaczeck, Rüdiger; Pietsch, Hubertus; Hütter, Joachim; Cibik, Levent; Gerlach, Martin; Krumrey, Michael; Fratzscher, Daniel; Arkadiev, Vladimir; Wedell, Reiner; Haschke, Michael; Langhoff, Norbert; Wust, Peter; Lüdemann, Lutz

2009-06-01

Photoelectric-enhanced radiation therapy is a bimodal therapy, consisting of the administration of highly radiation-absorbing substances into the tumor area and localized regional irradiation with orthovoltage x-rays. Irradiation can be performed by a modified computed tomography (CT) unit equipped with an additional x-ray optical module which converts the polychromatic, fan-shaped CT beam into a monochromatized and focused beam for energy-tuned photoelectric-enhanced radiotherapy. A dedicated x-ray optical module designed for spatial collimation, focusing, and monochromatization was mounted at the exit of the x-ray tube of a clinical CT unit. Spectrally resolved measurements of the resulting beam were performed using an energy-dispersive detection system calibrated by synchrotron radiation. The spatial photon fluence was determined by film dosimetry. Depth-dose measurements were performed and compared to the polychromatic CT and a therapeutic 6 MV beam. The spatial dose distribution in phantoms using a rotating radiation source (quasimonochromatic CT and 6 MV, respectively) was investigated by gel dosimetry. The photoelectric dose enhancement for an iodine fraction of 1% in tissue was calculated and verified experimentally. The x-ray optical module selectively filters the energy of the tungsten Kalpha emission line with an FWHM of 5 keV. The relative photon fluence distribution demonstrates the focusing characteristic of the x-ray optical module. A beam width of about 3 mm was determined at the isocenter of the CT gantry. The depth-dose measurements resulted in a half-depth value of approximately 36 mm for the CT beams (quasi-monochromatic, polychromatic) compared to 154 mm for the 6 MV beam. The rotation of the radiation source leads to a steep dose gradient at the center of rotation; the gel dosimetry yields an entrance-to-peak dose ratio of 1:10.8 for the quasi-monochromatic CT and 1:37.3 for a 6 MV beam of the same size. The photoelectric dose enhancement

Photoelectric-enhanced radiation therapy with quasi-monochromatic computed tomography

International Nuclear Information System (INIS)

Jost, Gregor; Mensing, Tristan; Golfier, Sven; Lawaczeck, Ruediger; Pietsch, Hubertus; Huetter, Joachim; Cibik, Levent; Gerlach, Martin; Krumrey, Michael; Fratzscher, Daniel; Arkadiev, Vladimir; Wedell, Reiner; Haschke, Michael; Langhoff, Norbert; Wust, Peter; Luedemann, Lutz

2009-01-01

Photoelectric-enhanced radiation therapy is a bimodal therapy, consisting of the administration of highly radiation-absorbing substances into the tumor area and localized regional irradiation with orthovoltage x-rays. Irradiation can be performed by a modified computed tomography (CT) unit equipped with an additional x-ray optical module which converts the polychromatic, fan-shaped CT beam into a monochromatized and focused beam for energy-tuned photoelectric-enhanced radiotherapy. A dedicated x-ray optical module designed for spatial collimation, focusing, and monochromatization was mounted at the exit of the x-ray tube of a clinical CT unit. Spectrally resolved measurements of the resulting beam were performed using an energy-dispersive detection system calibrated by synchrotron radiation. The spatial photon fluence was determined by film dosimetry. Depth-dose measurements were performed and compared to the polychromatic CT and a therapeutic 6 MV beam. The spatial dose distribution in phantoms using a rotating radiation source (quasi-monochromatic CT and 6 MV, respectively) was investigated by gel dosimetry. The photoelectric dose enhancement for an iodine fraction of 1% in tissue was calculated and verified experimentally. The x-ray optical module selectively filters the energy of the tungsten Kα emission line with an FWHM of 5 keV. The relative photon fluence distribution demonstrates the focusing characteristic of the x-ray optical module. A beam width of about 3 mm was determined at the isocenter of the CT gantry. The depth-dose measurements resulted in a half-depth value of approximately 36 mm for the CT beams (quasi-monochromatic, polychromatic) compared to 154 mm for the 6 MV beam. The rotation of the radiation source leads to a steep dose gradient at the center of rotation; the gel dosimetry yields an entrance-to-peak dose ratio of 1:10.8 for the quasi-monochromatic CT and 1:37.3 for a 6 MV beam of the same size. The photoelectric dose enhancement factor

Photoelectric-enhanced radiation therapy with quasi-monochromatic computed tomography

Energy Technology Data Exchange (ETDEWEB)

Jost, Gregor; Mensing, Tristan; Golfier, Sven; Lawaczeck, Ruediger; Pietsch, Hubertus; Huetter, Joachim; Cibik, Levent; Gerlach, Martin; Krumrey, Michael; Fratzscher, Daniel; Arkadiev, Vladimir; Wedell, Reiner; Haschke, Michael; Langhoff, Norbert; Wust, Peter; Luedemann, Lutz [TRG Diagnostic Imaging, Bayer Schering Pharma AG, 13353 Berlin (Germany); Department of Radiotherapy, Charite Medical Centre, 13353 Berlin (Germany); TRG Diagnostic Imaging, Bayer Schering Pharma AG, 13353 Berlin (Germany); Physikalisch-Technische Bundesanstalt, 10587 Berlin (Germany); Institute of Applied Photonics e.V., 12489 Berlin (Germany); Institute for Scientific Instruments GmbH, 12489 Berlin (Germany); Department of Radiotherapy, Charite Medical Centre, 13353 Berlin (Germany)

2009-06-15

Photoelectric-enhanced radiation therapy is a bimodal therapy, consisting of the administration of highly radiation-absorbing substances into the tumor area and localized regional irradiation with orthovoltage x-rays. Irradiation can be performed by a modified computed tomography (CT) unit equipped with an additional x-ray optical module which converts the polychromatic, fan-shaped CT beam into a monochromatized and focused beam for energy-tuned photoelectric-enhanced radiotherapy. A dedicated x-ray optical module designed for spatial collimation, focusing, and monochromatization was mounted at the exit of the x-ray tube of a clinical CT unit. Spectrally resolved measurements of the resulting beam were performed using an energy-dispersive detection system calibrated by synchrotron radiation. The spatial photon fluence was determined by film dosimetry. Depth-dose measurements were performed and compared to the polychromatic CT and a therapeutic 6 MV beam. The spatial dose distribution in phantoms using a rotating radiation source (quasi-monochromatic CT and 6 MV, respectively) was investigated by gel dosimetry. The photoelectric dose enhancement for an iodine fraction of 1% in tissue was calculated and verified experimentally. The x-ray optical module selectively filters the energy of the tungsten K{alpha} emission line with an FWHM of 5 keV. The relative photon fluence distribution demonstrates the focusing characteristic of the x-ray optical module. A beam width of about 3 mm was determined at the isocenter of the CT gantry. The depth-dose measurements resulted in a half-depth value of approximately 36 mm for the CT beams (quasi-monochromatic, polychromatic) compared to 154 mm for the 6 MV beam. The rotation of the radiation source leads to a steep dose gradient at the center of rotation; the gel dosimetry yields an entrance-to-peak dose ratio of 1:10.8 for the quasi-monochromatic CT and 1:37.3 for a 6 MV beam of the same size. The photoelectric dose enhancement

Opposite effects of WR-2721 and WR-1065 on radiation-induced hypothermia: possible correlation with oxygen uptake

International Nuclear Information System (INIS)

Kandasamy, S.B.; Kumar, K.S.; Hunt, W.A.; Weiss, J.F.

1988-01-01

Ionizing radiation induces hypothermia in guinea pigs. While systemic injection of the radioprotectant S-2-(3-aminopropylamino)ethylphosphorothioic acid (WR-2721) did not block hyperthermia induced by exposure to 10 Gy of gamma radiation, central administration did attenuate it. The dephosphorylated metabolite of WR-2721, N-(2-mercaptoethyl)-1,3-diaminopropane (WR-1065), accentuated radiation-induced hypothermia by both routes of administration. In brain homogenates, oxygen uptake was inhibited by WR-2721 but elevated by WR-1065. These results suggest that the antagonism of radiation-induced hypothermia found only after central administration of WR-2721 is due to its direct actions and not to its dephosphorylated metabolite and that this effect may be correlated with the inhibition by WR-2721 of oxygen uptake

Evaluation of occupational radiation dose in nuclear medicine: radiopharmaceutical administration to scintiscanning exams of myocardial perfusion; Avaliacao da dose de radiacao ocupacional em medicina nuclear: administracao de radiofarmacos em exames de cintilografria de perfusao miocardica

Energy Technology Data Exchange (ETDEWEB)

Komatsu, Cassio V., E-mail: cassiok@yahoo.com [Medicina Nuclear do Triangulo (MNT), Uberlandia, MG (Brazil); Michelin, Charlie A.; Jakubiak, Rosangela R., E-mail: charlie@utfpr.edu.br, E-mail: requi@utfpr.edu.br [Universidade Tecnologica Federal do Parana (UTFPR), Curitiba, PR (Brazil); Lemes, Alyne O.; Silva, Juliana L.M., E-mail: alyne275@gmail.com, E-mail: jujumontesdocinho@gmail.com [Faculdade do Trabalho (FATRA), Uberlandia, MG (Brazil)

2013-11-01

In nuclear medicine, workers directly involved in exams are constantly exposed to ionizing radiation. The procedure for administration of the radiopharmaceutical to the patient is one of the most critical times of exposure. In tests of myocardial perfusion scintigraphy (MPS) administration of radiopharmaceutical repeats the steps of rest and cardiac stress. In this study, we used a Geiger -Mueller detector for measuring occupational radiation doses for during the administration of technetium- {sup 99m}- sestamibi in MPS tests. In the evaluation, discriminated the stages of examination and related professional experience time to doses measures at home. It were followed 110 procedures at home (55 conducted by professionals with over 5 years experience and 55 conducted by professionals with less than 1 year of experience) and 55 effort procedures. The results showed that the rest of the procedure time and dose are related to the experience of the worker. More experienced workers were faster (mean: 43 {+-} 16 vs 67 {+-} 25 seconds / procedure), and therefore received lower doses (mean 0.57 {+-} 0.16 versus 0.80 {+-} 0.24 {mu}Sv / procedure), both with statistical significance (p <0.001). In step effort, there were procedures lasting longer (mean: 19 {+-} 2 minutes / procedure), which resulted in higher doses (mean 3.0 {+-} 0.6 {mu}Sv / procedure)

Radiation Shielding Utilizing A High Temperature Superconducting Magnet

Data.gov (United States)

National Aeronautics and Space Administration — Project objective is to evaluate human radiation protection and architecture utilizing existing superconducting magnet technology while attempting to significantly...

Radiation effects and radiation risks

International Nuclear Information System (INIS)

Lengfelder, E.; Forst, D.; Feist, H.; Pratzel, H.

1988-01-01

The book presents the facts and the principles of assessment and evaluation of biological radiation effects in general and also with particular reference to the reactor accident of Chernobyl, reviewing the consequences and the environmental situation on the basis of current national and international literature, including research work by the authors. The material compiled in this book is intended especially for physicians, but will also prove useful for persons working in the public health services, in administration, or other services taking care of people. The authors tried to find an easily comprehensible way of presenting and explaining the very complex processes and mechanisms of biological radiation effects and carcinogenesis, displaying the physical primary processes and the mechanisms of the molecular radiation effects up to the effects of low-level radiation, and present results of comparative epidemiologic studies. This section has been given considerable space, in proportion to its significance. It also contains literature references for further reading, offering more insight and knowledge of aspects of special subject fields. The authors also present less known results and data and discuss them against the background of well-known research results and approaches. Apart from the purpose of presenting comprehensive information, the authors intend to give an impact for further thinking about the problems, and helpful tools for independent decisions and action on the basis of improved insight and assessment, and in this context particularly point to the problems induced by the Chernobyl reactor accident. (orig./MG) With 8 maps in appendix [de

Core Flight Executive Software Radiation Mitigation Study

Data.gov (United States)

National Aeronautics and Space Administration — The reliability of SmallSat / CubeSat missions may be increased by using software radiation mitigation for single event upsets (SEUs). Implementing protection in...

Determinants of Patient Satisfaction During Receipt of Radiation Therapy

Energy Technology Data Exchange (ETDEWEB)

Famiglietti, Robin M., E-mail: rfamigli@mdanderson.org; Neal, Emily C.; Edwards, Timothy J.; Allen, Pamela K.; Buchholz, Thomas A.

2013-09-01

Purpose: To evaluate the correlations and relative contributions of components of a radiation oncology-specific patient satisfaction survey to their overall satisfaction scores. Methods and Materials: From September 2006 through August 2012, we prospectively collected data from 8069 patients receiving radiation treatments with a 26-question survey. Each question was rated on a 10-point Likert scale. We analyzed the correlation between scores for each question and the overall satisfaction question. We also dichotomized the scores to reflect satisfaction versus dissatisfaction and used logistic regression to assess the relationship between items in 4 domains (the patient–provider relationship, access and environmental issues, wait times, and educational information) and overall satisfaction. Results: Scores on all questions correlated with overall patient satisfaction scores (P<.0001). Satisfaction with patient–provider relationships had the greatest influence on overall satisfaction (R{sup 2}=0.4219), followed by wait times (R{sup 2}=0.4000), access/environment (R{sup 2}=0.3837), and patient education (R{sup 2}=0.3700). The specific variables with the greatest effect on patient satisfaction were the care provided by radiation therapists (odds ratio 1.91) and pain management (odds ratio 1.29). Conclusions: We found that patients' judgment of provider relationships in an outpatient radiation oncology setting were the greatest contributors to their overall satisfaction ratings. Other measures typically associated with patient satisfaction (phone access, scheduling, and ease of the check-in process) correlated less strongly with overall satisfaction. These findings may be useful for other practices preparing to assess patient ratings of quality of care.

Novel Formulation Strategy to Improve the Feasibility of Amifostine Administration.

Science.gov (United States)

Ranganathan, Kavitha; Simon, Eric; Lynn, Jeremy; Snider, Alicia; Zhang, Yu; Nelson, Noah; Donneys, Alexis; Rodriguez, Jose; Buchman, Lauren; Reyna, Dawn; Lipka, Elke; Buchman, Steven R

2018-03-19

Amifostine (AMF), a radioprotectant, is FDA-approved for intravenous administration in cancer patients receiving radiation therapy (XRT). Unfortunately, it remains clinically underutilized due to adverse side effects. The purpose of this study is to define the pharmacokinetic profile of an oral AMF formulation potentially capable of reducing side effects and increasing clinical feasibility. Calvarial osteoblasts were radiated under three conditions: no drug, AMF, and WR-1065 (active metabolite). Osteogenic potential of cells was measured using alkaline phosphatase staining. Next, rats were given AMF intravenously or directly into the jejunum, and pharmacokinetic profiles were evaluated. Finally, rats were given AMF orally or subcutaneously, and blood samples were analyzed for pharmacokinetics. WR-1065 preserved osteogenic potential of calvarial osteoblasts after XRT to a greater degree than AMF. Direct jejunal AMF administration incurred a systemic bioavailability of 61.5%. Subcutaneously administrated AMF yielded higher systemic levels, a more rapid peak exposure (0.438 vs. 0.875 h), and greater total systemic exposure of WR-1065 (116,756 vs. 16,874 ng*hr/ml) compared to orally administered AMF. Orally administered AMF achieves a similar systemic bioavailability and decreased peak plasma level of WR-1065 compared to intravenously administered AMF, suggesting oral AMF formulations maintain radioprotective efficacy without causing onerous side effects, and are clinically feasible.

Report on nuclear and radiation safety in Slovenia in 1999

International Nuclear Information System (INIS)

Lovincic, D.

2000-09-01

The Slovenian Nuclear Safety Administration (SNSA) has prepared Report on Nuclear and Radiation Safety in Slovenia in 1999. This is one of the regular forms of reporting on the work of the Administration to the Government and National Assembly of the Republic of Slovenia.

Software for radiation protection

International Nuclear Information System (INIS)

Graffunder, H.

2002-01-01

The software products presented are universally usable programs for radiation protection. The systems were designed in order to establish a comprehensive database specific to radiation protection and, on this basis, model in programs subjects of radiation protection. Development initially focused on the creation of the database. Each software product was to access the same nuclide-specific data; input errors and differences in spelling were to be excluded from the outset. This makes the products more compatible with each other and able to exchange data among each other. The software products are modular in design. Functions recurring in radiation protection are always treated the same way in different programs, and also represented the same way on the program surface. The recognition effect makes it easy for users to familiarize with the products quickly. All software products are written in German and are tailored to the administrative needs and codes and regulations in Germany and in Switzerland. (orig.) [de

Radiation monitoring for uranium miners: evaluation and optimization. Final report 9 Sep 79-9 Oct 81

International Nuclear Information System (INIS)

Schiager, K.J.; Borak, T.B.; Johnson, J.A.

1981-01-01

Radiological health risks to uranium miners are reviewed. Radiation measurement methods and monitoring systems that are now, or soon could be, available are reviewed with respect to their reliability and cost for determining annual exposures. Criteria for optimization of radiation monitoring programs are presented and applied to the current exposure conditions and available monitoring methods. The following recommendations are offered: (1) Personal thermoluminescent dosimeters for gamma exposures should be provided to all underground employees in uranium mines. (2) exposures to long-lived radionuclides in respirable dust and to airborne radon progency should be measured by randomized grab sampling. (3) regulations of the Mine Safety and Health Administration should place greater emphasis on exposure reduction, as opposed to documentation

Research on radiation control as presented in the Medical Service Law

International Nuclear Information System (INIS)

Takahashi, Yasuyuki; Shinohara, Hisashi; Narimatsu, Takaki; Kawamata, Isao; Miguchi, Hiroshi; Sunayashiki, Tadashi.

1997-01-01

We considered it important to determine how each municipal government interprets and promulgates the Medical Service Law as it affects the field of radiology and procedures such as general X-ray diagnosis, CT, RI, radiation therapy and MR imaging. Only the government administrative segment referred to as the medical supervisory body can observe, control and generally administer front-line medical sites such as hospitals and clinics. This administrative body should have better public health care as its objective and should be able to adapt to changes in technology and the environment. We consider that, under the current climate of rapid technological change, medical supervision cannot be effective unless teams of specialists from each field are involved in administrative guidance. With the goal of achieving optimal and effective use of medical radiology, a questionnaire survey was done to gather information. Two questions were raised: Is there sufficient interaction between public medical supervisors and radiologists? and how well do people on the front lines at medical sites understand the current control structure? (author)

Control measures in industrial and medical applications of radiation

International Nuclear Information System (INIS)

Akinloye, M. K.

1999-01-01

Radiation and radioactive substances are natural and permanent features of the environment; additionally the use of human made radiation is widespread. Sources of radiation are essential to modern health care, disposable medical supplies sterilized by intense radiation have been central to combating disease, radiology is a vital diagnostic tool and radiotherapy is commonly part of the treatment of malignancies. Nuclear techniques are in growing use in industry, agriculture, medicine and many fields of research, benefiting hundreds of millions of people and giving employment to millions of people in the related occupations, Irradiation is used around the world to preserve and reduce wastage and sterilization techniques have been used to eradicate disease carrying insects and pests. Industrial radiography is in routine use, for example to examine welds and detect cracks and help prevent the failure of engineered structures. It is also known that exposure to ionizing radiation can result to injuries that manifest themselves in the individual and his descendants. It is therefore imperative that the use of radiation sources be accompanied with the methods necessary for the prevention of the harmful effects of the radiation. These methods are referred to as control measures. Control measures that have been applied in establishments can be classified into physical control measures and administrative control measures. Physical control measures involve the technical aspects while administrative control measures augment physical measures. The guidelines and recommendations for the safe use of radiation and radioactive materials are provided through legislative and regulatory controls

Polyolefin-Nanocrystal Composites for Radiation Shielding, Phase I

Data.gov (United States)

National Aeronautics and Space Administration — EIC Laboratories Inc. is proposing a lightweight multifunctional polymer/nanoparticle composite for radiation shielding during long-duration lunar missions. Isolated...