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Sample records for administrar dosis terapeutica

  1. Methodology to administer therapeutic dose of I-131; Metodologia para administrar dosis terapeutica de I-131

    Energy Technology Data Exchange (ETDEWEB)

    Basteris M, J.; Gomez D, R. [Universidad Autonoma de Yucatan, Facultad de Medicina, Merida, Yucatan (Mexico)

    2007-07-01

    The present work suggests the use of measures guided to eliminate the resulting chronic sialoadenitis of the treatment of the thyroid cancer with Iodine-131, as well as the use of citric fruits to stimulate the salivation, the post-dose administration of liquids to accelerate the gastric emptying avoiding the secondary effects as the vomit is included. (Author)

  2. Methodology for management of therapeutic dose of I-131; Metodologia para administrar dosis terapeutica de I-131

    Energy Technology Data Exchange (ETDEWEB)

    Basteris M, J.; Gomez D, R. [Universidad Autonoma de Yucatan, Facultad de Medicina, Merida, Yucatan (Mexico)

    2007-07-01

    The present work suggests the use of measures guided to eliminate the resulting chronic sialoadenitis of the treatment previously described with a therapeutic dose bigger than ablative of Iodine 131, as well as the use of citric fruits to stimulate the salivation, the administration of liquid post-dose is included to accelerate the gastric emptying avoiding the secondary effects as the vomit. (Author)

  3. INCREMENTO TRANSITORIO DE LA PRESION ARTERIAL SISTEMICA EN PACIENTES NORMOTENSOS CON TERAPEUTICA ACUPUNTURAL

    OpenAIRE

    RECAMIER TORRES, BERNARDO DEL SAGRADO CORAZON DE JESUS

    2009-01-01

    INTRODUCCION. LA PRESION ARTERIAL SISTEMICA RESULTADO DE LA INTERACCION DE FACTORES NEUROENDOCRINOS SOBRE EL TONO VASCULAR SISTEMICO Y VOLUMEN SANGUINEO CIRCULANTE, ES MODIFICADA POR LA TERAPEUTICA ACUPUNTURAL A TRAVES DEL INCREMENTO DE NEUROPEPTIDOS COMO ENDORFINAS, Y SUS PRECURSORES, (SITUACION DEMOSTRADA POR LAS EXPERIENCIAS DE POMERANZ). ESTE AUMENTO DE LA ACTIVIDAD EN LA RED CEFALO SUPRARRENAL CONLLEVA A UN INCREMENTO EN LA PRESION ARTERIAL SISTEMICA QUE REQUIERE DE MECANISMOS COMPENSAD...

  4. Accurate DOSY measure of out-of-equilibrium systems by permutated DOSY (p-DOSY)

    CERN Document Server

    Oikonomou, Maria; Velders, Aldrik H; Delsuc, Marc-André

    2015-01-01

    NMR spectroscopy is a perfect tool for monitoring in-situ chemical reactions. In particular, DOSY measurement is well suited to characterize transient species by the determination of their sizes. However, here we bring to light a difficulty in the DOSY experiments performed on out-of-equilibrium systems. On such a system, the evolution of the concentration of species interferes with the measurement process, and creates a bias on the diffusion coefficient determination that may lead to erroneous interpretations. We show that a random permutation of the series of gradient strengths used during the DOSY experiment allows to average out this bias. This approach, that we name p-DOSY does not require changes in the the pulse sequences nor in the processing software, and restores completely the full accuracy of the measure. This technique is demonstrated on the monitoring of the anomerization reaction of $\\alpha$ to $\\beta$ glucose.

  5. Vacunación de la hepatitis B. Indicaciones del test serológico postvacunal y la dosis de refuerzo

    Directory of Open Access Journals (Sweden)

    Pallás Álvarez José Ramón

    2000-01-01

    Full Text Available En relación con la hepatitis B, la vacunación estándar permite, en la gran mayoría de los casos, un título de anti-HBs protector (>10 UI/l. Sin embargo, la duración efectiva de la memoria inmunológica no es bien conocida todavía. Como consecuencia de ello, las recomendaciones en el seguimiento postvacunal han sido dispares: desde no realizar seguimiento hasta realizar tests serológicos postvacunales (título de anti-HBs de manera regular. En los sujetos no protegidos tras la vacunación primaria, la dosis de refuerzo ha demostrado ser efectiva. Pero el procedimiento más adecuado para su utilización en función del título de anti-HBs alcanzado no está bien establecido. Se recomienda el test postvacunal y la monitorización serológica periódica únicamente en determinados grupos de riesgo, fundamentalmente en personal sanitario y en personas inmunodeprimidas. En estos casos la dosis de refuerzo se debe aplicar en los sujetos no respondedores, utilizando incluso el doble de la dosis habitual. No existe todavía un estado de consenso respecto a la temporalidad más adecuada para administrar la dosis de refuerzo.

  6. Análisis de métricas de similitud en razonamiento basado en casos para administrar proyectos

    OpenAIRE

    Rodríguez, Guillermo Horacio; Berdun, Luis S.; Soria, Alvaro; Amandi, Analía; Campo, Marcelo

    2015-01-01

    La administración de proyectos de software es crucial para el desarrollo controlado de los productos de software. Sin embargo, cuando un administrador de proyectos experimentado abandona el proyecto y es reemplazado por alguien con menor experiencia y sin conocimiento del entorno del proyecto, aparece la Amnesia Organizacional. En efecto, administrar un proyecto de software se convierte en una tarea costosa, con incertidumbre y escasa garantía de éxito. En este contexto, Razonamiento Basado e...

  7. Reconstrucción de dosis a partir del efecto pre-dosis del cuarzo: procedimiento combinado de dosis aditiva y activación múltiple

    Directory of Open Access Journals (Sweden)

    V. Correcher

    2009-01-01

    Full Text Available El efecto pre-dosis del pico de termoluminiscencia (TL de 110±C del cuarzo da lugar a la utilización de técnicas muy sensibles para la estimación retrospectiva de dosis bajas. Sin embargo, se pudo observar que alícuotas de la misma fracción mineral presentaban distintos cambios de sensibilidad, por lo que se desarrolló un nuevo protocolo de medida basado en el mencionado efecto pre-dosis. Este procedimiento permite determinar de forma simultánea: (i cambios de sensibilidad inducidos por la activación térmica y (ii dependencia de la señal TL con la dosis, con una secuencia de medida donde se combinan las técnicas de dosis aditiva (DA y activación múltiple (AM. La dosis estimada se obtiene por interpolación lo que permite una mayor precisión y exactitud del resultado.

  8. Studies on supramolecular gel formation using DOSY NMR

    Czech Academy of Sciences Publication Activity Database

    Nonappa, N.; Šaman, David; Kolehmainen, E.

    2015-01-01

    Roč. 53, č. 4 (2015), s. 256-260. ISSN 0749-1581 Institutional support: RVO:61388963 Keywords : DOSY * VT NMR * gel * diffusion coefficients Subject RIV: CF - Physical ; Theoretical Chemistry Impact factor: 1.179, year: 2014

  9. Lumbar sympathectomy under CT guidance: therapeutic option in critical limb ischaemia; la simpaticolisi TC guidata: alternativa terapeutica delle ischemie critiche

    Energy Technology Data Exchange (ETDEWEB)

    Pieri, Stefano; Agresti, Paolo [Az. Osp. S. Camillo-Forlanini, Roma (Italy). U.O. di radiologia vascolare ed interventistica; Ialongo, Pasquale; Fedeli, Stefano [Radiologia diagnostica Busi, Roma (Italy); Di Cesare, Fabio; Ricci, Guiseppe [Az. Osp. S. Camillo-Forlanini, Roma (Italy). Chirurgia vascolare

    2005-04-01

    simpaticectomia lombare e un'opzione terapeutica complementare, destinata a quei pazienti con grave arteriopatia perierica degli srti inferiori, allo stadio terminale, che presentino dolore a riposo e gagrena e che non vengano riconosciuti idonei per un tentativo di rivascolarizzazione chirurgica. La simpatectomia lombare chirurgica, con tecnica tradizionale, e stata ampiamente utilizzata in passato, ma, in virtu dell'invasivita, e stata nel tempo accantonata a favore delle tecniche percutanee, anche se recentemente sono stati riportati casi di trattamento con tecnica laparoscopica. La simpaticectomia lombare percutanea e invece un'opzione terapeutica sicura, poco costosa e facilmente disponibile. Riportiamo la nostra esperienza su 19 casi, eseguiti sotto controllo TC. Materiale e metodi: Tra il 1998 e il 2002, la procedura di simpaticolisi percutanea sotto controllo TC e stata effettuata in 19 pazienti. Tutti i pazienti presentavano un'arteriopatia degli arti inferiori al IV stadio di Fontaine, con dolore a riposo e gangrena; non erano stati considerati idonei per un tentativo di rivascolarizzazione chirurgica. Due aghi da 22 G, lunghi 15 cm, sono stati utilizzati per iniettare fenolo a livello di L2 e L4. I segni dell'interruzione dell'attivita simpatica compaiono 2'-15' dopo la procedura e comprendono calore e arrossamento. Risultati: La procedura si e rivelata semplice, sicura, ben tollerata dai pazienti, con una bassa percentuale di complicanze. Dei 19 pazienti, 9 (47.3%) hanno mostrato un miglioramento del quadro clinico, mentre 5 hanno fatto registrare un peggioramento della loro condizione ischemica nei mesi successivi. Discussione: I risultati suggeriscono che la procedura di simpaticectomia lombare percutanea e in grado di causare un blocco del plesso simpatico nei pazienti con un'arteriopatia degli arti inferiori in fase avanzata. L'assistenza fornita dalla TC consente un'elevata precisione nella somministrazione

  10. Amyloïdosis, sarcoidosis and systemic lupus erythematosus.

    Science.gov (United States)

    Rezgui, Amel; Hassine, Imene Ben; Karmani, Monia; Fredj, Fatma Ben; Laouani, Chadia

    2016-01-01

    The occurrence of renal and multiple organ Amyloïdosis is currently considered exceptional in the course of systemic lupus erythematosus. We report a case of a concomitant SLE and Amyloïdosis in a 57 year old female patient with hypothyroidism history, who presented with erythema nodosum, fever, arthralgia and sicca syndrome. Biological findings showed an inflammatory syndrome, renal failure, proteinuria (1g / 24h), positive auto antibodies and anti DNA. Lung radiology revealed medistinal lymphadenopathy, pleural nodules, ground glass infiltrates and pleuritis. Bronchial biopsy showed non specific inflammation. The salivary gland biopsy showed amyloïd deposits. This case report reminds us that lupus and Amyloïdosis association, although exceptional remains possible. The occurrence of Lofgren syndrome in this situation make the originality of this report. PMID:27583087

  11. Production of teaching materials of nuclear medicine for use in career of Imagenologia Diagnostica y Terapeutica of the Escuela de Tecnologias de Salud of the Universidad de Costa Rica

    International Nuclear Information System (INIS)

    One of the main obstacles in the career of Imagenologia Diagnostica y Terapeutica of the Escuela de Tecnologias de Salud of the Universidad de Costa Rica has been access to bibliographic material of reference in Spanish. The topics most relevant of nuclear medicine of interest to imaging specialist and other disciplines as: medicine, physics, pharmacy and nursing, have been identified for the purpose of having a bibliographic body; experts have reviewed the selection in each subject. Topics of interest were identified and grouped into five specific teaching areas: 1. Radiation protection, 2. Quality Control of Nuclear Medicine Instruments, 3. Radiopharmacy, 4. Planar Nuclear Medicine, 5. Nuclear Medicine SPECT and PET. (author)

  12. Dosis de radiación ultravioleta en escolares mexicanos

    Directory of Open Access Journals (Sweden)

    Castanedo-Cázares Juan Pablo

    2003-01-01

    Full Text Available OBJETIVO: Determinar la dosis de radiación ultravioleta que reciben los niños y adolescentes durante su asistencia a la escuela primaria, secundaria o preparatoria en la ciudad de San Luis Potosí. MATERIAL Y MÉTODOS: Estudio de cohorte hecho en la ciudad de San Luis Potosí entre mayo de 2001 y abril de 2002. Se evaluaron 80 escolares escogidos al azar de 6 a 19 años de edad, de uno u otro sexo. La dosis se cuantificó durante todo un ciclo escolar mediante el registro del tiempo de exposición solar para cada uno de los alumnos, de modo simultáneo al monitoreo de radiación ultravioleta, para lo cual se utilizaron equipos de radiometría terrestre. Se excluyeron las vacaciones y los fines de semana. Los datos se analizaron en forma univariada y comparativamente, por sexo y meses de exposición; además, se buscó un modelo de regresión para explicar la dosis de exposición solar. RESULTADOS: La dosis promedio ajustada al espectro de eritematógeno acción fue de 16 456 J/m²/año.Hubo diferencias por género: 14 264 J/m²/año/mujeres vs. 18 648 J/m²/año/hombres (Kolmogorov-Smirnof, p=0.003. No hubo diferencias significativas entre grupos, pero sí entre los meses de exposición (Kruskall-Wallis, p=<0.0001. Utilizando la técnica estadística de modelos lineales generalizados, y mediante técnica escalonada y calificación del índice de Akaike se escogió el mejor modelo que explica la dosis de radiación según el mes de exposición, mediante la fórmula 587.20+438.45 (género+500.16(mes-49.65(mes². El resultado muestra mayores dosis de radiación de marzo a septiembre. CONCLUSIONES: Proponemos un marco teórico para la creación de políticas dirigidas a proteger a los alumnos de la sobrexposición solar durante su asistencia a la escuela en México. Se justifica la implantación de medidas preventivas durante al menos el periodo de mayor exposición (marzo a junio, ya que en este lapso se recibe 51% de la dosis anual de radiaci

  13. PALMA, an improved algorithm for DOSY signal processing

    CERN Document Server

    Cherni, Afef; Delsuc, Marc-André

    2016-01-01

    NMR is a tool of choice for the measure of diffusion coefficients of species in solution. The DOSY experiment, a 2D implementation of this measure, has proven to be particularly useful for the study of complex mixtures, molecular interactions, polymers, etc. However, DOSY data analysis requires to resort to inverse Laplace transform, in particular for polydisperse samples. This is a known difficult numerical task, for which we present here a novel approach. A new algorithm based on a splitting scheme and on the use of proximity operators is introduced. Used in conjunction with a Maximum Entropy and $\\ell_1$ hybrid regularisation, this algorithm converges rapidly and produces results robust against experimental noise. This method has been called PALMA. It is able to reproduce faithfully monodisperse as well as polydisperse systems, and numerous simulated and experimental examples are presented. It has been implemented on the server http://palma. labo.igbmc.fr where users can have their datasets processed autom...

  14. Estimasi Dosis Alumunium Sulfat pada Proses Penjernihan Air Menggunakan Metode Genetic Algorithm

    Directory of Open Access Journals (Sweden)

    Meilinda Ayundyahrini

    2013-09-01

    Full Text Available Kualitas air minum tergantung dari kekeruhan dan pH. Proses koagulasi merupakan proses utama penjernihan air yang bertujuan untuk mengikat partikel-partikel dalam air menggunakan koagulan. Hubungan kualitas air dan dosis membentuk kurva U sehingga dosis optimum merupakan titik minimum dari kurva. Ketika pemberian dosis tidak tepat maka bisa merusak kualitas air itu sendiri. Metode yang digunakan untuk mencari dosis minimum adalah Algoritma Genetika dengan tahapan meliputi normalisasi data, stratifikasi, inialisasi populasi, evaluasi individu, seleksi turnamen, pindah silang, mutasi, dan elitisme. Persamaan least square error dan kesalahan sesaat digunakan sebagai persamaan fitness. Pencarian persamaan optimum dibagi menjadi dua musim, yaitu musim kemarau dan penghujan. Musim kemarau, persamaan optimum didapat dengan mengelompokkan data menjadi tiga kelompok waktu menggunakan persamaan kesalahan sesaat. Sedangkan pada musim penghujan, persamaan optimum didapatkan melalui pengelompokan data menjadi tiga golongan terhadap kekeruhan menggunakan persamaan kesalahan sesaat. Hasil simulasi menunjukkan jika data estimasi dosis mampu mengikuti data dosis tawas perusahaan.

  15. The DOSIS and DOSIS 3D Experiments onboard the International Space Station - Results from the Active DOSTEL Instruments

    Science.gov (United States)

    Burmeister, Soenke; Berger, Thomas; Reitz, Guenther; Beaujean, Rudolf; Boehme, Matthias; Haumann, Lutz; Labrenz, Johannes; Kortmann, Onno

    2012-07-01

    Besides the effects of the microgravity environment, and the psychological and psychosocial problems experienced in confined spaces, radiation is the main health detriment for long duration human space missions. The radiation environment encountered in space differs in nature from that on earth, consisting mostly of high energetic ions from protons up to iron, resulting in radiation levels far exceeding the ones present on earth for occupational radiation workers. Accurate knowledge of the physical characteristics of the space radiation field in dependence on the solar activity, the orbital parameters and the different shielding configurations of the International Space Station ISS is therefore needed. For the investigation of the spatial and temporal distribution of the radiation field inside the European COLUMBUS module the experiment DOSIS (Dose Distribution Inside the ISS) under the lead of DLR was launched on July 15th 2009 with STS-127 to the ISS. The experimental package was transferred from the Space Shuttle into COLUMBUS on July 18th. It consists of a combination of passive detector packages (PDP) distributed at 11 locations inside the European Columbus Laboratory and two active radiation detectors (DOSTELs) with a DDPU (DOSTEL Data and Power Unit) in a nomex pouch (DOSIS MAIN BOX) mounted at a fixed location beneath the European Physiology Module rack (EPM) inside COLUMBUS. The DOSTELs measured during the lowest solar minimum conditions in the space age from July 18th 2009 to June 16th 2011. In July 2011 the active hardware was transferred to ground for refurbishment and preparation for the DOSIS-3D experiment. The hardware will be launched with the Soyuz 30S flight to the ISS on May 15th 2012 and activated approximately ten days later. Data will be transferred from the DOSTEL units to ground via the EPM rack which is activated approximately every four weeks for this action. First Results for the active DOSIS-3D measurements such as count rate profiles

  16. Long term dose monitoring onboard the European Columbus module of the International Space Station (ISS) in the frame of the DOSIS and DOSIS 3D project

    Science.gov (United States)

    Berger, Thomas

    The radiation environment encountered in space differs in nature from that on earth, consisting mostly of high energetic ions from protons up to iron, resulting in radiation levels far exceeding the ones present on earth for occupational radiation workers. Accurate knowledge of the physical characteristics of the space radiation field in dependence on the solar activity, the orbital parameters and the different shielding configurations of the International Space Station (ISS) is therefore needed. For the investigation of the spatial and temporal distribution of the radiation field inside the European Columbus module the experiment “Dose Distribution Inside the ISS” (DOSIS), under the project and science lead of the German Aerospace Center (DLR), was launched on July 15th 2009 with STS-127 to the ISS. The DOSIS experiment consists of a combination of “Passive Detector Packages” (PDP) distributed at eleven locations inside Columbus for the measurement of the spatial variation of the radiation field and two active Dosimetry Telescopes (DOSTELs) with a Data and Power Unit (DDPU) in a dedicated nomex pouch mounted at a fixed location beneath the European Physiology Module rack (EPM) for the measurement of the temporal variation of the radiation field parameters. The DOSIS experiment suite measured during the lowest solar minimum conditions in the space age from July 2009 to June 2011. In July 2011 the active hardware was transferred to ground for refurbishment and preparation for the follow up DOSIS 3D experiment. The hardware for DOSIS 3D was launched with Soyuz 30S to the ISS on May 15th 2012. The PDPs are replaced with each even number Soyuz flight starting with Soyuz 30S. Data from the active detectors is transferred to ground via the EPM rack which is activated once a month for this action. The presentation will give an overview of the DOSIS and DOSIS 3D experiment and focus on the results from the passive radiation detectors from the DOSIS 3D experiment

  17. Como administrar cuidados domiciliares: o custo e o preço do preparo e do trabalho da enfermagem uma experiência Como administrar cuidados domiciliares: el costo y el precio de la preparación y del trabajo de la enfermería una experiencia How to manage home-care service: the cost and price of the training and the work of the nursing professional an experience

    OpenAIRE

    Vivian Schutz; Joséte Luzia Leite; Nébia Maria Almeida de Figueiredo

    2007-01-01

    Relato de experiência sobre o custo da administração de cuidados domiciliares, considerando a seleção, treinamento e supervisão do profissional. A questão norteadora baseou-se no custo da administração do cuidado domiciliar em uma instituição, que prepara os profissionais de enfermagem para realizar os cuidados. Seus objetivos foram: relatar o custo da seleção e treinamento de pessoal de enfermagem para o cuidado domiciliar; e discutir o processo de administrar os cuidados domiciliares com de...

  18. System of data management in 'Dosis' personal dosimetry

    International Nuclear Information System (INIS)

    The storage and control of the data of a service of personal dosimetry is a task that requires specify care in data handling and manipulation. This activity becomes more annoying of making manually when the volume of users of the service is significant. The External Dosimetric Laboratory of the Center for Radiation Protection and Hygiene has developed a system of administration of data that allows the storage, control and analysis of the data generated by the Service of Personal Dosimetry in an efficient and reliable way. This paper describes the characteristics of the System for Administration of Data in Personal Dosimetry 'Dosis', as well as their design and programming. The importance of this System for the laboratory and the advantages of their application are described. The characteristics of the different modules are also described. (author)

  19. Radiotoxicity, dose and nuclear alchemy; Radiotoxiciteit, dosis en nucleaire alchemie

    Energy Technology Data Exchange (ETDEWEB)

    Schram, R. [Nuclear Research and Consultancy Group NRG, Petten (Netherlands)

    2006-07-01

    An outline is given of the nuclear fuel cycle and related products, focusing on the radiotoxicity and radioactive waste dose. Also, it is explained how those subjects form the basis of research on transmutation and recycling of radioactive waste. Finally, attention will be paid to nuclear alchemy, i.e. the steps to be taken for transmutation and recycling, based on current developments in research at NRG. [Dutch] In dit artikel zal een toelichting worden gegeven op de splijtstofcyclus en de producten die daarbij vrijkomen. Hierbij zal worden ingegaan op de radiotoxiciteit en dosis van het radioactief anal. Tevens zal worden uitgelegd hoe deze begrippen de basis vormen voor keuzes binnen het onderzoek naar transmutatie en recycling van radioactief afval. Ook zal de nucleaire alchemie, de benodigde stappen voor transmutatie en recycling, worden behandeld aan de hand van de actuele ontwikkelingen in het onderzoek zoals onder meer uitgevoerd bij NRG.

  20. Optimasi Dosis Pupuk Dolomit pada Tanaman Kelapa Sawit (Elaeis Guineensis Jacq. Belum Menghasilkan Umur Satu Tahun

    Directory of Open Access Journals (Sweden)

    - Sudradjat

    2015-09-01

    Full Text Available Kelapa sawit merupakan komoditi perkebunan utama karena sebagai sumber devisa negara dan menyediakan lapangan kerja. Indonesia adalah negara produsen terbesar kelapa sawit di dunia dengan luas areal mencapai 10.1 juta hektar. Peningkatan produktivitas dicapai dengan intensifikasi antara lain dengan melakukan rasionalisasi pemupkan. Penelitian ini bertujuan untuk menentukan dosis optimum pupuk dolomit pada tanaman kelapa sawit belum menghasilkan umur satu tahun. Penelitian ini dilaksanakan di Kebun Pendidikan dan Penelitian Kelapa Sawit IPB-Cargill, Jonggol, Bogor dari bulan Maret 2013 sampai Maret 2014. Rancangan yang digunakan adalah Faktorial Tunggal,  dosis pupuk dolomit,  yang disusun dalam lingkungan Acak Kelompok dengan tiga ulangan. Dosis pupuk dolomit yang diuji  terdiri atas 0, 200, 400, dan 600 g tanaman-1 tahun-1. Hasil penelitian menunjukkan bahwa pupuk dolomit meningkatkan secara nyata terhadap peubah tinggi tanaman, diameter batang, jumlah daun, dan kandungan khlorofil daun, namun tidak berpengaruh terhadap kandungan Mg dalam jaringan daun. Berdasarkan tanggap peubah tinggi tanaman, dosis optimum pupuk dolomit untuk tanaman kelapa sawit pada umur satu tahun adalah 306.4 g dolomit tanaman-1tahun -1. Kata kunci: dolomit, dosis optimum, kelapa sawit, respons fisiologi, respons morfologi.

  1. DOSIS SEMANAL DE HIERRO EN MUJERES ADOLESCENTES DE MORELOS (MÉXICO)

    OpenAIRE

    G. González-Rosendo; J. D. Fernández-Ballart; J. J. Rodríguez-Jerez; J. Sánchez-Muñoz; A. G. Quintero-Gutiérrez

    2008-01-01

    El objetivo de este estudio fue probar la utilidad de la dosis semanal de hierro en el tratamiento y prevención de la anemia ferropénica en mujeres adolescentes. Se realizó un ensayo clínico con 3 grupos, uno recibió dosis diaria de hierro, otro semanal y el grupo control (no anémicas) sin suplementación. Se determinó hemoglobina y hematocrito antes y después de 16 semanas de suplementación. Se determinó peso, talla, circunferencia de cintura y cadera. Los valores de hemoglobina se incrementa...

  2. Characterization of reactive intermediates by multinuclear diffusion-ordered NMR spectroscopy (DOSY).

    Science.gov (United States)

    Li, Deyu; Keresztes, Ivan; Hopson, Russell; Williard, Paul G

    2009-02-17

    Nuclear magnetic resonance (NMR) is the most powerful and widely utilized technique for determining molecular structure. Although traditional NMR data analysis involves the correlation of chemical shift, coupling constant, and NOE interactions to specific structural features, a largely overlooked method introduced more than 40 years ago, pulsed gradient spin-echo (PGSE), measures diffusion coefficients of molecules in solution, thus providing their relative particle sizes. In the early 1990s, the PGSE sequence was incorporated into a two-dimensional experiment, dubbed diffusion-ordered NMR spectroscopy (DOSY), in which one dimension represents chemical shift data while the second dimension resolves species by their diffusion properties. This combination provides a powerful tool for identifying individual species in a multicomponent solution, earning the nickname "chromatography by NMR". In this Account, we describe our efforts to utilize DOSY techniques to characterize organometallic reactive intermediates in solution in order to correlate structural data to solid-state crystal structures determined by X-ray diffraction and to discover the role of aggregate formation and solvation states in reaction mechanisms. In 2000, we reported our initial efforts to employ DOSY techniques in the characterization of reactive intermediates such as organolithium aggregates. Since then, we have explored DOSY experiments with various nuclei beyond (1)H, including (6)Li, (7)Li, (11)B, (13)C, and (29)Si. Additionally, we proposed a diffusion coefficient-formula weight relationship to determine formula weight, aggregation number, and solvation state of reactive intermediates. We also introduced an internal reference system to correlate the diffusion properties of unknown reactive intermediates with known inert molecular standards, such as aromatic compounds, terminal olefins, cycloolefins, and tetraalkylsilanes. Furthermore, we utilized DOSY to interpret the role of aggregation number

  3. Toxicidad de VA-DIFTET® por administración a dosis repetida en ratones

    Directory of Open Access Journals (Sweden)

    Pablo González

    2000-06-01

    Full Text Available Una vez estudiada la toxicidad de la vacuna VA-DIFTET® (vacuna antidiftérica antitetánica por administración a dosis única en dos especies de animales, se impone la evaluación a dosis repetida, teniendo en cuenta que el esquema de inmunización en humanos prevé la aplicación de tres dosis cuando el componente pertusis de la DPT está contraindicado. Se emplearon 210 ratones OF-1 de ambos sexos. Los grupos experimentales fueron similares a los de la prueba a dosis única con la vacuna dúplex, anatoxina diftérica, anatoxina tetánica, adyuvante, tiomersal, solución salina fisiológica y un grupo control no tratado. Un grupo de hembras y otro de machos fue asignado aleatoriamente a cada tratamiento y para recibir 1, 2 ó 3 dosis por vía intramuscular. Tras cada aplicación se evaluó la aparición de síntomas clínicos, el incremento de peso, el consumo de agua y alimento y la dinámica de la respuesta inmune contra las anatoxinas tetánica y diftérica, específicamente de tipo IgG, mediante ELISA indirecto. Al término de las observaciones los animales fueron sacrificados y se realizaron estudios anatomopatológicos. Además, durante el sacrificio se evaluó el índice relativo de bazo y timo, así como la relación bazo/timo. No se comprobaron alteraciones que evidenciaran toxicidad por parte de la vacuna y sus componentes. Asimismo, se demostró una marcada respuesta inmune en los grupos vacunales e inoculados con las anatoxinas. Se considera que los resultados de la prueba fueron satisfactorios.

  4. con el uso de cuatro dosis de nitrógeno

    Directory of Open Access Journals (Sweden)

    Tomás Díaz Valdés

    2014-01-01

    Full Text Available La producción intensiva de maíz en zonas semiáridas se sustenta principalmente el agua y la fertilización nitrogenada, se busca hacer un manejo eficiente del agua y óptimo del nitrógeno (N, con la finalidad de mejorar el ingreso del productor y reducir la contaminación de las aguas subordinadas a las áreas agrícolas. El objetivo de este estudio fue determinar la eficiencia del uso del agua y la dosis óptima de nit rógeno mediante la aplicación de cuat ro dosis de N en maíz. El exper imento se llevo en Si naloa, México. El diseño exper iment al f ue u n bloque completo al azar con cuatro repeticiones. Los tratamientos fueron control (0, 150, 300, 450 y 600 kg de N·ha -1 . Las variables evaluadas fueron: eficiencia en el uso del agua (EUA índice de cosecha (IC y rendimiento de grano (Yg. En las dosis de 300 y 450 kg de N·ha -1 provocaron un efecto significativo en la EUA, IC y Yg. La dosis óptima de N fue de 477 kg de N·ha -1 , que ocasionó un rendimiento máximo de 9,89 Mg·ha -1 . La dosis óptima económica de N fue de 341 kg de N·ha -1 , con esta se obtuvo un rendimiento de 9,44 Mg·ha -1 .

  5. Development of DosiMap: dosimetry device for radiotherapy quality assurance; Developpement du DosiMap: instrument de dosimetrie pour le controle qualite en radiotherapie

    Energy Technology Data Exchange (ETDEWEB)

    Frelin, A.M

    2006-10-15

    This thesis deals with the development of a new dosimetry device for the control of radiotherapy beams. This device is composed of a plane plastic scintillator which is set within a polystyrene phantom. When the 'DosiMap' is irradiated, light is produced. This light is composed of scintillation and Cerenkov radiation, and is accurately measured by a C.C.D. camera. The analysis of the light distribution enables us to deduce the dose distribution in the scintillator plan. This device has many advantages such as tissue equivalence, a good spatial resolution, and a linear response with regard to energy. It also provides immediate measurements, and as a consequence, it is a very adapted tool for clinical use. After the introduction about the basic notions of radiotherapy, the different steps of the 'DosiMap' development are exposed in this thesis. In a first time, plastic scintillators have been tested to determine the best one for this application. Then, the deconvolution of scintillation and Cerenkov radiation have been studied, because we only use scintillation to calculate the dose distribution. The camera being in the irradiation room, a lead shield has also been developed to protect the C.C.D. detector from scattered radiations. Finally, the dose calibration and the dose response of 'DosiMap' are exposed. All this work made feasible the measurement of dose distributions with a precision which turns out to be better than 2% for homogeneous photon beams. Excellent results were also obtained when modulated intensity beams are used. (author)

  6. Long term dose monitoring onboard the European Columbus module of the international space station (ISS) in the frame of DOSIS and DOSIS 3D project - results from the active instruments

    Science.gov (United States)

    Burmeister, Soenke; Berger, Thomas; Reitz, Guenther; Boehme, Matthias; Haumann, Lutz; Labrenz, Johannes

    Besides the effects of the microgravity environment, and the psychological and psychosocial problems encountered in confined spaces, radiation is the main health detriment for long duration human space missions. The radiation environment encountered in space differs in nature from that on earth, consisting mostly of high energetic ions from protons up to iron, resulting in radiation levels far exceeding the ones encountered on earth for occupational radiation workers. Accurate knowledge of the physical characteristics of the space radiation field in dependence on the solar activity, the orbital parameters and the different shielding configurations of the International Space Station ISS is therefore needed. For the investigation of the spatial and temporal distribution of the radiation field inside the European COLUMBUS module the experiment DOSIS (Dose Distribution Inside the ISS) under the lead of DLR has been launched on July 15 (th) 2009 with STS-127 to the ISS. The experimental package was transferred from the Space Shuttle into COLUMBUS on July 18 (th) . It consists of a combination of passive detector packages (PDP) distributed at 11 locations inside the European Columbus Laboratory and two active radiation detectors (Dosimetry Telescopes = DOSTELs) with a DDPU (DOSTEL Data and Power Unit) in a Nomex pouch (DOSIS MAIN BOX) mounted at a fixed location beneath the European Physiology Module rack (EPM) inside COLUMBUS. The active components of the DOSIS experiment were operational from July 18 (th) 2009 to June 16 (th) 2011. After refurbishment the hardware has been reactivated on May 15 (th) 2012 as active part of the DOSIS 3D experiment and provides continuous data since this activation. The presentation will focus on the latest results from the two DOSTEL instruments as absorbed dose, dose equivalent and the related LET spectra gathered within the DOSIS (2009 - 2011) and DOSIS 3D (2012 - 2014) experiment. The CAU contributions to DOSIS and DOSIS 3D are

  7. Metástasis óseas. Tratamiento convencional a dosis altas versus fraccionamiento no convencional con dosis equivalente. Análisis uni y multivariante

    OpenAIRE

    Gutiérrez Bayard, Lucía

    2006-01-01

    El tratamiento paliativo de las metástasis óseas con Radioterapia Externa, está bien establecido por su eficacia, sin embargo, sigue el debate acerca de la dosis óptima, régimen de fraccionamiento y su duración. En general, en pacientes con una expectativa de vida limitada, se acepta que deberían recibir un tratamiento efectivo en el menor tiempo posible, siendo la toxicidad aguda el principal problema, sobre todo la fractura patológica. La toxicidad a largo plazo es rara vez vista, dado que ...

  8. Analysis of adulterated herbal medicines and dietary supplements marketed for weight loss by DOSY 1H NMR

    OpenAIRE

    VAYSSE, Julie; BALAYSSAC, Stéphane; GILARD, Véronique; DESOUBZDANNE, Denis; MALET-MARTINO, Myriam; Martino, Robert

    2010-01-01

    Abstract Twenty herbal medicines or dietary supplements marketed as natural slimming products were analyzed by Diffusion Ordered SpectroscopY (DOSY) 1H NMR and DOSY-COSY 1H NMR. The method allows analysis of the whole sample with detection of both active and inactive ingredients in these complex matrices. Among the 20 formulations analyzed, 2 were strictly herbal and 4 had a composition corresponding to declared ingredients on the packaging or the leaflet. The others were all adult...

  9. Optimasi Dosis Pupuk Dolomit pada Tanaman Kelapa Sawit (Elaeis Guineensis Jacq.) Belum Menghasilkan Umur Satu Tahun

    OpenAIRE

    - Sudradjat; - Fitriya

    2015-01-01

    Kelapa sawit merupakan komoditi perkebunan utama karena sebagai sumber devisa negara dan menyediakan lapangan kerja. Indonesia adalah negara produsen terbesar kelapa sawit di dunia dengan luas areal mencapai 10.1 juta hektar. Peningkatan produktivitas dicapai dengan intensifikasi antara lain dengan melakukan rasionalisasi pemupkan. Penelitian ini bertujuan untuk menentukan dosis optimum pupuk dolomit pada tanaman kelapa sawit belum menghasilkan umur satu tahun. Penelitian ini dilaksanakan di ...

  10. Development of DosiMap: dosimetry device for radiotherapy quality assurance

    International Nuclear Information System (INIS)

    This thesis deals with the development of a new dosimetry device for the control of radiotherapy beams. This device is composed of a plane plastic scintillator which is set within a polystyrene phantom. When the 'DosiMap' is irradiated, light is produced. This light is composed of scintillation and Cerenkov radiation, and is accurately measured by a C.C.D. camera. The analysis of the light distribution enables us to deduce the dose distribution in the scintillator plan. This device has many advantages such as tissue equivalence, a good spatial resolution, and a linear response with regard to energy. It also provides immediate measurements, and as a consequence, it is a very adapted tool for clinical use. After the introduction about the basic notions of radiotherapy, the different steps of the 'DosiMap' development are exposed in this thesis. In a first time, plastic scintillators have been tested to determine the best one for this application. Then, the deconvolution of scintillation and Cerenkov radiation have been studied, because we only use scintillation to calculate the dose distribution. The camera being in the irradiation room, a lead shield has also been developed to protect the C.C.D. detector from scattered radiations. Finally, the dose calibration and the dose response of 'DosiMap' are exposed. All this work made feasible the measurement of dose distributions with a precision which turns out to be better than 2% for homogeneous photon beams. Excellent results were also obtained when modulated intensity beams are used. (author)

  11. PERAN ASOSIASI Synechococcus sp. TERHADAP PROTEIN DAN PRODUKSI BIJI TANAMAN KEDELAI PADA BERBAGAI DOSIS BOKASHI

    Directory of Open Access Journals (Sweden)

    Abadi Darma Setia

    2013-08-01

    Full Text Available [ENGLSIH]Seed of soybean is known contained proteins that are good to consume. Soybean is able to live in mutualistic symbiosis with Rhizobium bacteria and non-symbiotic association with photosynthetic bacteria of Synechococcus sp. This bacteria can be a biofertilizer for plants even in unfavorable environmental conditions these bacteria can still contribute nutrients N from N2 fixation in the air. The conducted research aims to study substance of seed protein, and also the plant productions (Glycine max. L. Merill which is associated with Synechococcus sp. strain Situbondo in various dosages of bokashi. To address this aim, a research was conducted at the Agrotechnopark field Jember University. The research was based on Split-split plot design with two factors, those are bacterium innoculation, and Bokashi rates. The Standard Error of Mean (SEM was used as different mean test among treatments. The results of this research show that: (1 association of Synechococcus sp. in soybean plant tend to increase seed weight per plant by 34,61% and seed protein by 1,9% only in 0 kg/ha dosages of bokashi, however the effect of Synechococcus sp. was linier with the increasing dosages of bokashi. (2 Dosages of bokashi tend to increase seed protein content and seed weight per plant. Keywords: Glycine; Synechococcus sp.; Bokashi [INDONESIAN] Biji kedelai diketahui memiliki kandungan protein yang baik untuk dikonsumsi. Tanaman kedelai dapat bersimbiosis mutualisme dengan bakteri Rhizobium dan non simbiotik dengan bakteri fotosintetik Synechococcus sp. Bakteri ini dapat menjadi biofertilizer bagi tanaman bahkan dalam kondisi lingkungan yang tidak menguntungkan bakteri ini masih dapat menyumbang unsur hara N dari hasil fiksasi N2 di udara. Penelitian yang dilakukan bertujuan untuk mengetahui kandungan protein biji serta produksi tanaman kedelai yang berasosiasi dengan bakteri fotosintetik Synechococcus sp. Strain situbondo pada berbagai dosis bokasi. Penelitian

  12. Dose de insulina prescrita versus dose de insulina aspirada Dosis de insulina prescrita versus dosis de insulina aspirada Prescribed insulin dose versus prepared insulin dose

    Directory of Open Access Journals (Sweden)

    Thaís Santos Guerra Stacciarini

    2011-01-01

    Full Text Available OBJETIVOS: Comparar a dose aspirada de insulina na seringa à dosagem prescrita entre os usuários que a autoaplicam; relacionar as divergências às variáveis sociodemográficas e clínicas e identificar as dificuldades referidas no procedimento. MÉTODOS: Participaram do estudo 169 usuários acompanhados pela Estratégia Saúde da Família (ESF de um município do Estado de Minas Gerais, entre agosto e outubro de 2006. RESULTADOS: Entre os usuários que aspiraram doses diferentes da prescrita (36,1%, 77% justificaram dificuldade para visualizar a escala graduada da seringa e 29,5%, dificuldades motoras para manusear precisamente a seringa. O sexo (feminino, a idade (>60 anos e a escolaridade (OBJETIVOS: Comparar la dosis aspirada de insulina en la jeringa en la dosis prescrita entre los usuarios que la autoaplican; relacionar las divergencias a las variables sociodemográficas y clínicas e identificar las dificultades referidas en el procedimiento. MÉTODOS: Participaron en el estudio 169 usuarios acompañados por la Estrategia Salud de la Familia (ESF de un municipio del Estado de Minas Gerais, entre agosto y octubre del 2006. RESULTADOS: Entre los usuarios que aspiraron dosis diferentes de la prescrita (36,1%, 77% justificaron dificultad para visualizar la escala graduada de la jeringa y el 29,5%, dificultades motoras para manejar con precisión la jeringa. El sexo (femenino, la edad (>60 años y la escolaridad (OBJECTIVES: To compare the dose of prepared insulin to the dosage prescribed among users who self-administer; the differences relate to sociodemographic and clinical variables and identify the difficulties related to the procedure. METHODS: The study included 169 users of the Family Health Strategy (ESF of a municipality in the state of Minas Gerais, between August and October 2006. RESULTS: Among the users who administered different doses than were prescribed (36.1%, 77% identified difficulty viewing the graduated scale of the

  13. ESTIMACIÓN DE LA PREVALENCIA DE HIPOTIROIDISMO SEGÚN DIFERENTES MÉTODOS: DOSIS DIARIA DEFINIDA, DOSIS DIARIA PRESCRITAY REGISTRO DE PACIENTES EN TRATAMIENTO

    Directory of Open Access Journals (Sweden)

    José Escribano-Serrano

    2014-01-01

    Full Text Available Fundamentos: El hipotiroidismo (HT es una patología frecuente en la práctica clínica diaria. No existen datos recientes sobre su prevalencia en España. El objetivo de este trabajo fue conocer su prevalencia en la provincia de Cádiz. Métodos: Se estudió el consumo del grupo terapéutico H03AA realizado en receta oficial por las unidades de Atención Primaria (AP de Cádiz, durante el año 2012. La prevalencia se estimó mediante tres métodos: la Dosis Diaria Definida (DDD, la Dosis Diaria Prescrita (DDP y el Registro Pacientes en Tratamiento (RPT. Los resultados se presentaron según sexo y edad con intervalos de confianza del 95%. Resultados: La prevalencia de HT durante 2012 en población mayor de 15 años de la provincia fue del 1,36% (IC95: 1,33%-1,38% mediante DDD, del 2,60% (IC95: 2,54%-2,66% mediante DDP y del 3,10% (IC95: 2,85%-2,93% mediante RPT. La mediana de edad fue de 56 años (rango intercuartílico 43 a 68 años. La prevalencia (RPT por sexo fue de 0,75% en hombres y 5,36% en mujeres [OR 7,26 (IC95: 7,02-7,52], siendo del 9,35% la correspondiente a mujeres de 51 a 70 años. Conclusiones: El método de estimación por rptdemuestra ser una herramienta más válida que el método DDD para evaluar la prevalencia de HT. El HT muestra, en nuestra provincia una prevalencia elevada con mayor afectación del sexo femenino.

  14. Como administrar cuidados domiciliares: o custo e o preço do preparo e do trabalho da enfermagem uma experiência Como administrar cuidados domiciliares: el costo y el precio de la preparación y del trabajo de la enfermería una experiencia How to manage home-care service: the cost and price of the training and the work of the nursing professional an experience

    Directory of Open Access Journals (Sweden)

    Vivian Schutz

    2007-06-01

    Full Text Available Relato de experiência sobre o custo da administração de cuidados domiciliares, considerando a seleção, treinamento e supervisão do profissional. A questão norteadora baseou-se no custo da administração do cuidado domiciliar em uma instituição, que prepara os profissionais de enfermagem para realizar os cuidados. Seus objetivos foram: relatar o custo da seleção e treinamento de pessoal de enfermagem para o cuidado domiciliar; e discutir o processo de administrar os cuidados domiciliares com destaque para as facilidades e dificuldades que os profissionais de enfermagem encontram para que a assistência domiciliar seja realizada. Como metodologia foi usado o relato de atividades desenvolvidas por uma empresa que presta serviços para que sejam realizados os cuidados domiciliares. Como resultados foram elaboradas três categorias: estratégias de recrutamento e custo da seleção dos profissionais de enfermagem para a assistência domiciliar; custos com o treinamento do pessoal selecionado para assistência domiciliar; e alocação dos profissionais treinados no mercado de cuidados domiciliares e particulares. Para a realização de uma adequada assistência domiciliar, conclui-se que é necessário contar com bons profissionais de enfermagem e, para que isso ocorra, deve-se treiná-los adequadamente após o seu recrutamento e seleção.Relato de experiencia sobre el custo de la administración de los cuidados domiciliares, considerando la selección, entrenamiento y supervisión del profesional. La cuestión norteadora del estudio fué basada en la custo de la administración del cuidado domiciliar en una institución preparadora de profesionales para la realización de los cuidados. Sus objetivos fueron: Relatar el custo de la selección y entrenamiento de personal de Enfermería para el cuidado domiciliar; y discutir el proceso de administrar los cuidados domiciliares con evidencia en las facilidades y dificultades que los

  15. EFECTO DE LA INTERACCIÓN ABONO VERDE-DOSIS DE NITRÓGENO

    Directory of Open Access Journals (Sweden)

    Margarita García

    2000-01-01

    Full Text Available Con el objetivo de cuantificar el aporte de N en unidades fertilizantes del abono verde C anavalia ensiformis en rotación con la papa, se llevó a cabo un experimento de campo en el período 1992-1995 sobre un suelo Ferralítico Rojo de La Habana. Los tratamientos consistieron en la combina- ción factorial del uso o no del abono verde con cinco dosis de N (0, 40, 80, 120 y 160 kg.ha –1 , distribuidas en el campo de acuerdo con un diseño de parcelas divididas y cinco répli- cas. Los resultados mostraron respuestas positivas de la papa a la aplicación de N, a la incorporación del abonado verde y a la integración de ambas alternativas. La magnitud de la respuesta a la aplicación de diferentes dosis de N estuvo en dependencia del uso o no del abono verde. En este sentido, en la campaña 1992-1993 con el uso de la canavalia se encon- traron rendimientos máximos de 33 t.ha -1 con sólo la aplica- ción de 53 kg.ha -1 de N (32 % de la dosis máxima; en la cam- paña 1994-1995, por su parte, se encontraron los máximos rendimientos (29 t.ha -1 con sólo la aplicación de 67 kg.ha -1 de N (50 % de la dosis máxima. Con el uso de la canavalia como abono verde solo, se obtuvieron rendimientos de la papa de 25 t.ha -1 equivalentes a la aplicación de 80 kg.ha -1 de N. Cuando no se emplearon los abonos verdes, la respuesta a la fertilización nitrogenada fue lineal, encontrándose los máximos rendimientos (34.8 t.ha -1 en la campaña 1992-1993 con la apli cación de 160 kg.ha -1 de N, siendo estos de 29 t.ha -1 con la aplicación de 130 kg.ha -1 en la campaña 1994-1995.

  16. KEMAMPUAN DOSIS PUPUK ZA DAN WAKTU PEWIWILAN TUNAS LATERAL TERHADAP HASIL DAN KUALITAS CABAI BESAR

    Directory of Open Access Journals (Sweden)

    Imam Taufik

    2013-08-01

    Full Text Available [ENGLISH]Chili is one of the horticultural commodities which have high economic value and have a large export opportunities. The development of technology makes great chili farming business will be more profitable. The purpose of research to determine the interaction between fertilizer dosing ZA and pruning time of lateral shoots that are most influential to the outcome and quality of hot pepper. Factorial (3 x 3 research carried out using Random Design Group. The first factor is the fertilizer doses studied with 3 threshold ZA covers: N1, N2, and N3, respectively 14, 28, and 42 grams per plant. The second factor is the time of pruning with 3 degrees include: W1, W2, and W3, each for 0, 15, and 25 days after planting. The results showed that the combination treatment of ZA 28 gram per plant and prunning of lateral shoots in 15 dat tend to the best result on the yield and quality of chilli. Keywords: Chilli; ZA Fertilizer Dose; Nitrogen; Pruning.  [INDONESIAN] Cabai merupakan salah satu komoditas hortikultura yang memiliki nilai ekonomi tinggi serta memiliki peluang eksport yang besar. Perkembangan teknologi menjadikan usaha pertanian cabai besar akan semakin menguntungkan. Tujuan penelitian untuk mengetahui interaksi antara pemberian dosis pupuk ZA dan waktu pewiwilan tunas lateral yang berpengaruh paling baik terhadap hasil dan kualitas cabai besar. Penelitian faktorial (3x3 dilaksanakan menggunakan Rancangan Acak Kelompok. Faktor pertama yang diteliti adalah dosis pupuk ZA dengan 3 taraf yang meliputi: N1, N2, dan N3 ,masing-masing 14, 28, dan 42 gram per tanaman. Faktor kedua adalah waktu pewiwilan dengan 3 taraf meliputi: W1, W2, dan W3, masing- masing untuk 0, 15, dan 25 hari setelah tanam. Hasil penelitian menunjukkan bahwa kombinasi perlakuan ZA 28g/tanaman dan pewiwilan tunas lateral umur 15 hari setelah tanam cenderung memberikan hasil terbaik terhadap hasil dan kualitas cabai besar. Kata Kunci: Cabai Besar; Dosis Pupuk ZA; Nitrogen

  17. ANALISIS DOSIS OUTPUT BERKAS ELEKTRON PESAWAT TELETERAPI LINEAR ACCELERATOR (LINAC)TIPE VARIAN HCX 6540 MENGGUNAKAN TRS 398

    OpenAIRE

    Rahayu, Ivonnie Indri

    2015-01-01

    Telah dilakukan penelitian tentang analisis dosis output berkas elektron pesawat teleterapi linear acceleration (LINAC) tipe Varian HCX 6540 dengan energi 6 MeV, 9 MeV, 12 MeV dan 15 MeV menggunakan protokol Technical Report Series (TRS) 398 IAEA. Penelitian ini bertujuan untuk mengukur dosis radiasi output elektron pesawat LINAC tipe HCX 6540 untuk energi 6 MeV, 9 MeV, 12 MeV dan 15 MeV dengan menggunakan water phantom,kemudian hasil tersebut dibandingkan dengan standar pada protokol TRS 398...

  18. Cálculo de dosis realistas : un método para evaluar el efecto de los descendientes

    OpenAIRE

    Sánchez León, José Guillermo

    2006-01-01

    Las metodologías de cálculo de dosis "realistas", como la CREAM, requieren la evaluación de numerosos parámetros que en aplicaciones prácticas pueden no ser viables ni estar justificados. En muchos casos son innecesariamente complicados. Una estimación no será mas realista por el hecho de ser más compleja, de hecho va en contra del criterio de Ockham habitualmente utilizado en la investigación científica. Nos hemos de preguntar: ¿Puede hablarse de dosis realista cuando no es posible contr...

  19. Low-dose glucocorticoids in hyperandrogenism Efecto de bajas dosis de glucocorticoides en el hiperandrogenismo

    Directory of Open Access Journals (Sweden)

    Leonardo Rizzo

    2007-06-01

    Full Text Available To investigate the effect of low-doses of glucocorticoids on androgen and cortisol secretion during the course of the day, we evaluated clinical signs of hyperandrogenism and total, free and bioavailable testosterone, SHBG, and cortisol following two different protocols: A fourteen patients received betamethasone 0.6 mg/day (n=8 or methylprednisolone 4 mg/day (n=6, as single daily oral dose at 11.00 PM, during 30 days, B fourteen patients were evaluated under betamethasone 0.3 mg in a single daily dose at 11.00 PM during six months, 11 out of whom were re-evaluated six months later. Twenty eight women with hyperandrogenism were included and seven normal females were used as control. Blood samples were taken in follicular phase at 8 AM and 7 PM to determine SHBG, cortisol, total, free and bioavailable testosterone. In both protocols, a significant morning and evening decrease in cortisol and testosterone (pCon el objetivo de investigar el efecto de bajas dosis de glucocorticoides sobre la secreción de andrógenos y cortisol en el curso del día, evaluamos signos de hiperandrogenismo, testosterona total, libre y biodisponible y cortisol según dos protocolos diferentes: A catorce pacientes recibieron betametasona 0.6 mg/día (n= 8 o metilprednisolona 4 mg/día (n= 6 en dosis única cotidiana, a las 23 h, durante 30 días, B catorce pacientes fueron evaluadas bajo betametasona 0.3 mg en dosis única cotidiana a la 23 h, administrada durante 6 meses; de ellas, 11 pacientes fueron re-evaluadas 6 meses más tarde. Se incluyeron 28 mujeres con hiperandrogenismo y 7 controles normales. Se obtuvieron muestras de sangre en fase folicular a las 08:00 y 9:00 h para determinar SHBG, cortisol, testosterona total, libre y biodisponible. En ambos protocolos se observó una disminución significativa de cortisol y testosterona (p<0.05 a <0.01, más importante con betametasona (p<0.05. En el protocolo B, los niveles matutinos de SHBG aumentaron

  20. Impacto de la radiología digital en la dosis de referencia de radiología intraoral española

    OpenAIRE

    Velasco Hidalgo, Francisco

    2016-01-01

    INTRODUCCION: las dosis de referencia (DRLs) son los niveles de dosis administradas a los pacientes en exposiciones de radiodiagnóstico médico que no deben sobrepasarse y pueden ser utilizados como indicadores en los procesos de optimización radiológica. A raíz de las publicaciones iniciales para reducir las dosis de radiación en los EE.UU. En odontología, se incluyen estas recomendaciones en las directrices europeas sobre protección radiológica en radiología dental; sin embargo, hemos encont...

  1. La coazione terapeutica. Uno studio comparato

    OpenAIRE

    Pelazza,

    2014-01-01

    Il lavoro analizza in primo luogo la legislazione britannica concernente l'autodeterminazione in campo sanitario, e non solo, degli utenti psichiatrici e delle persone classificate come "incapaci". Viene preso in considerazione il sistema inglese perchè propone una disciplina molto dettagliata, specie se paragonata alle poche norme presenti nell'ordinamento italiano. Queste ultime vengono analizzate nella seconda parte della tesi, dopo una panoramica sui principi internazionali (in particolar...

  2. Distancia entre plantas y dosis de nitrógeno y potasio en sandía sin semillas fertirrigada

    OpenAIRE

    Anderson Luiz Feltrim; Arthur Bernardes Cecílio Filho; Marcus Vinicius Gonsalves; Luiz Carlos Pavani; José Carlos Barbosa; Juan Waldir Mendoza Cortez

    2011-01-01

    El objetivo de este trabajo fue evaluar los efectos de dosis de N y K2O, vía fertirrigación por goteo, y de la distancia entre plantas sobre la productividad del híbrido Shadow de sandía sin semillas. El experimento se realizó de agosto a octubre de 2008 en el Município de Tupã, SP, Brazil. Se avaluaran cuatro dosis de N + K2O (79,8 + 106,7, 106,4 + 142,2, 133,0 + 177,7, y 159,6 + 213,2 kg ha-1, respectivamente), y cuatro distancias entre plantas (0,5, 1,0, 1,5 y 2,0 m), en hileras espaciadas...

  3. Incertidumbres en la estimación de dosis a trabajadores expuestos a la inhalación de aerosoles

    OpenAIRE

    Sánchez León, José Guillermo; Pérez Fonseca, Agustín

    2003-01-01

    Un método muy empleado para estimar la dosis comprometidas a trabajadores expuestos habitualmente a la inhalación de aerosoles radiactivos consiste en medir las concentraciones de actividad en los puestos de trabajo utilizando tomamuestras fijos. El trabajador registra a lo largo de la jornada los periodos de tiempo que ha permanecido junto a cada tomamuestras. A partir de los tiempos de permanencia y de las concentraciones se estiman las incorporaciones individuales. Un estudio estadístico d...

  4. PENGARUH JENIS DAN DOSIS PUPUK TERHADAP PERTUMBUHAN TANAMAN GAHARU (Gyrinops sp.) DI BAWAH TEGAKAN PINUS DI HUTAN PENDIDIKAN UNIVERSITAS HASANUDDIN

    OpenAIRE

    Millang, Syamsuddin

    2014-01-01

    Tanaman gaharu merupakan salah satu jenis hasil hutan bukan kayu yang memiliki prospek pasar yang menjanjikan. Untuk itu perlu dibudidayakan secara luas baik dalam kawasan hutan maupun di luar kawasan hutan dalam bentuk sistem agroforestry. Penelitian ini bertujan untuk menemukan jenis pupuk (pupuk kandang, NPK, dan mulsa gamal) dan dosis yang tepat untuk pertumbuhan tanaman gaharu (Gyrinops sp.) di bawah tegakan Pinus merkusii di hutan pendidikan Universitas Hasanuddin. Penelitian ini di...

  5. Dosimetry Optimization System and Integrated Software (DOSIS): a comparison against Fluke code results over a standard phantom

    International Nuclear Information System (INIS)

    Dual-imaging facilities (PET-CT, SPECT-CT) allow obtainance of both mass and activity patient-speci c distributions perfectly correlated, which may improve dose distributions estimations and radioimmunotherapy treatment plani cations accuracy [1]. Calculation methods at voxel level require both quantitative and qualitative validation to obtain improvements in patient-speci c dosimetry [2]. This work presents advances of a novel computational tool dedicated to 3D patient-speci c dosimetry at voxel level. Focusing on providing a dosimetric tool at voxel level, as well as the development of a platform based on full-stochastic methods for alpha-, beta- and gamma-emitters used in radiopharmaceutical applications. DOSIS is based on the Boltzmann radiation transport equation to realize energy delivering calculations. Procedures have been designed tacking into account MIRD formalism and standards [3]. Anatomic and metabolic images, and dose maps resulting of this calculations are analysed and procesed by a special developed and designed software [4]. Finally, a dose calculation over a standard phantom is performed using DOSIS calculation code and FLUKA, validating the radiation transport code of DOSIS

  6. VALIDACION DE LA DOSIS DE DIALISIS MEDIDA CON ONLINE CLEARANCE MONITOR (OCM Y EL Kt/V DE DAUGIRDAS 93.

    Directory of Open Access Journals (Sweden)

    C. Lorenzo Ponce

    2004-01-01

    Full Text Available RESUMEN Introducción: La morbimortalidad de los pacientes en tratamiento con hemodiálisis periódica depende de la edad, enfermedad de base y la calidad del tratamiento. El índice de Kt/V es el patrón de referencia de medición de dosis de diálisis. El método de la dializancia iónica (OCM, FMC determina el Kt/V en tiempo real, mediante el aclaramiento de electrolitos. Evaluar si la medición de la dosis de diálisis mediante Kt/V medido por OCM se correlaciona con la dosis medida mediante el método de Daugirdas 93, ha sido el objetivo del presente estudio. Material y Métodos: Se estudiaron prospectivamente 24 pacientes anúricos en hemodiálisis 3 veces por semana, estables durante al menos 6 meses, de edad 64.75 ± 18.24 años, 16.7% mujeres y 20.8% diabéticos. La membrana utilizada fue polisulfona de alta permeabilidad (1.8 m2 y helixone (1.6 m2. El flujo del baño de diálisis no se varió. El cálculo del Kt/V Daugirdas 93 se realizó de acuerdo NKF-DOQI y el de OCM se determinó en la sesión intermedia semanal durante 3 semanas consecutivas. Los datos fueron procesados con SPSS 11.0 utilizando, regresión lineal, análisis de la varianza y t-student. Se consideró estadísticamente significativo con "p"Resultados: La OCM tiene una estrecha relación con el Kt/V determinado por Daugirdas 93 ( 1.29 ± 0.2 vs. 1.32 ± 0.2, p Conclusiones: La dosis determinada mediante OCM se correlaciona con el Kt/V de Daugirdas 93. Su aplicación, sin suponer sobrecarga de trabajo, permite el control adecuado de la diálisis, que la dosis prescrita sea obtenida constituyendo una herramienta de control de calidad y por consiguiente de adecuación de la terapia. Se necesitan estudios prospectivos que confirmen su influencia positiva sobre la morbimortalidad de los pacientes en hemodiálisis.

  7. Distancia entre plantas y dosis de nitrógeno y potasio en sandía sin semillas fertirrigada

    Directory of Open Access Journals (Sweden)

    Anderson Luiz Feltrim

    2011-09-01

    Full Text Available El objetivo de este trabajo fue evaluar los efectos de dosis de N y K2O, vía fertirrigación por goteo, y de la distancia entre plantas sobre la productividad del híbrido Shadow de sandía sin semillas. El experimento se realizó de agosto a octubre de 2008 en el Município de Tupã, SP, Brazil. Se avaluaran cuatro dosis de N + K2O (79,8 + 106,7, 106,4 + 142,2, 133,0 + 177,7, y 159,6 + 213,2 kg ha-1, respectivamente, y cuatro distancias entre plantas (0,5, 1,0, 1,5 y 2,0 m, en hileras espaciadas de 2,0 m. Se utilizó el diseño experimental de bloques al azar, en parcelas subdivididas, con tres repeticiones. Las variables evaluadas fueron: concentración foliar de N y K, peso medio de frutos, número de frutos y productividad total y comercial; y número de frutos en las clases de 3 a 5, 5 a 7, 7 a 9 kg y con más de 9 kg, por planta y por hectárea. Hubo efecto del factor dosis de N + K2O sobre la concentración foliar de K, y la productividad total y comercial de la sandía híbrido Shadow disminuyó linealmente con el aumento de la distancia entre plantas. Sin embargo, no hubo efecto significativo de la interacción ni efecto individual de los factores sobre las otras variables avaliadas.

  8. Sand as thermoluminescent dosimeter to therapeutic doses Arena como dosímetro termoluminiscente para dosis terapéuticas

    Directory of Open Access Journals (Sweden)

    Juana Salcedo

    2010-06-01

    Full Text Available This work describes the characteristic thermoluminiscent of sand coming from Coveñas beaches, for its use as therapeutic dose dosimeter. The selected samples, annealed at 400oC during 1 hour, were irradiated to different doses using an unit of 60Co Theratron 780C in air to ambient temperature. The reading was carried out in a Harshaw TLD 4500. The main dosimetric properties of the material (glow curve, response reproducibility, reutilization, linearity and thermal decay have been studied in detail. The glow curve of the sand samples presents a peaks TL at about 145◦C. The results show that the material has a linear response to the dose from 50 cGy until 1000 cGy. The studied sand samples can be used as thermoluminescent dosimeters for applications in different areas. The importance of this work is that the sand is a natural substance available in large quantities, low cost and can be used in clinical physics to evaluate the dose received by the patient during medical treatment.Este trabajo describe las características termoluminiscentes de arena proveniente de las playas de Coveñas para su uso como dosímetro en dosis terapéuticas. Las muestras seleccionadas, tratadas térmicamente a 400◦C por una hora, fueron irradiadas a diferentes dosis usando una unidad de 60Co Theratron 780C en aire a temperatura ambiente. La lectura se realizó en un Harshaw TLD 4500. Las principales propiedades dosimétricas del material (curva de brillo, reproducibilidad de la respuesta, reutilización, linealidad y decaimiento térmico han sido estudiadas en detalle. La curva de brillo de las muestras de arena presenta un pico TL alrededor de los 145◦C. Los resultados muestran que el material tiene una respuesta lineal con la dosis desde 50 cGy hasta 1000 cGy. Las muestras de arena estudiadas se pueden utilizar como dos´ımetros termoluminiscentes para aplicaciones en diferentes áreas. La importancia de este trabajo radica en que la arena es una sustancia

  9. Dosis única de ciclofosfamida disminuye la calidad espermática y el epitelio germinal masculino en ratones

    OpenAIRE

    Láyonal Acosta; Víctor Núñez; Jonathan Vásquez; José Pino; Betty Shiga

    2012-01-01

    Ciclofosfamida (CP) es un agente alquilante comúnmente utilizado como fármaco antineoplásico e inmunosupresor. El uso de CP, en el tratamiento de cáncer es limitado debido a su severa toxicidad. El objetivo del presente estudio fue determinar el efecto de una única dosis de CP (220 mg/kg peso corporal) administrada intraperitonealmente después de 7 días, sobre parámetros espermáticos y el epitelio germinal masculino en ratones. Se utilizó machos maduros de la cepa C57BL divididos en 2 grupos ...

  10. Experimental method for calculation of effective doses in interventional radiology; Metodo experimental para calculo de dosis efectivas en radiologia intervencionista

    Energy Technology Data Exchange (ETDEWEB)

    Herraiz Lblanca, M. D.; Diaz Romero, F.; Casares Magaz, O.; Garrido Breton, C.; Catalan Acosta, A.; Hernandez Armas, J.

    2013-07-01

    This paper proposes a method that allows you to calculate the effective dose in any interventional radiology procedure using an anthropomorphic mannequin Alderson RANDO and dosimeters TLD 100 chip. This method has been applied to an angio Radiology procedure: the biliary drainage. The objectives that have been proposed are: to) put together a method that, on an experimental basis, allows to know dosis en organs to calculate effective dose in complex procedures and b) apply the method to the calculation of the effective dose of biliary drainage. (Author)

  11. Valoración de la dosis de diálisis mediante dialisancia iónica

    Directory of Open Access Journals (Sweden)

    Rosa Caballero Barba

    2015-03-01

    Full Text Available Uno de los principales determinantes de la supervivencia de los pacientes en hemodiálisis es la dosis de la misma, las fórmulas comúnmente utilizadas son aquellas basadas en el modelo cinético de la urea. Sin embargo, debido a la necesidad de al menos dos muestras sanguíneas, su aplicabilidad a todas las sesiones de diálisis es bastante escasa. Actualmente casi todos los monitores de diálisis están provistos de sensores de dialisancia iónica, lo que nos permite obtener de forma indirecta y en tiempo real, información acerca del aclaramiento de urea en todas las sesiones de diálisis y sin necesidad de obtener muestras sanguíneas. Con el objetivo de evaluar la correlación que existe entre la dosis de diálisis medida por dialisancia iónica y aquella medida por cinética de Urea mediante la ecuación de KT/V monocompartimental de segunda generación según Daugirdas, diseñamos un estudio transversal que incluye 28 pacientes prevalentes de nuestra unidad de diálisis, obtuvimos datos de dosis de diálisis (aclaramiento, KT, KT/V por dialisancia iónica y el KT/V según fórmula de Daugirdas de segunda generación. La media de KT/V por dialisancia iónica fue de 1.79 ± 0.29 del KT/V según Daugirdas de 1.95 ± 0.35. En el análisis estadístico encontramos una importante correlación entre ambos métodos (R2 = 0.86 p< 0.001. Con los resultados de este estudio concluimos que la dialisancia iónica es una técnica útil para valorar la dosis de diálisis en nuestros pacientes y su uso debería generalizarse en las distintas unidades de diálisis.

  12. Gender-specific calculation of the effective dose: The example of thoracic computer tomography; Geschlechtsspezifische Bestimmung der effektiven Dosis am Beispiel von CT-Thoraxuntersuchungen

    Energy Technology Data Exchange (ETDEWEB)

    Boetticher, H. von [Inst. fuer Radilogie, Zentralkrankenhaus Links der Weser, Bremen (Germany); Lachmund, J. [Inst. fuer Radilogie, Zentralkrankenhaus Links der Weser, Bremen (Germany); Bremer Inst. fuer Praeventionsforschung, Sozialmedizin und Epidemiologie (BIPSE), Bremen (Germany); Hoffmann, W. [Inst. fuer Community Medicine, Greifswald Univ. (Germany)

    2003-07-01

    Systematic gender-specific differences in anatomy and physiology are mostly neglected in standard methodologies for the determination of effective doses. This paper presents and discusses three different concepts for the derivation of gender-specific effective doses. Based on the most convincing approach - especially through the influence of tissue weighting factors for the breast - the effective dose for a serial CT scan of the chest is higher for women (+11%) and lower (-11%) for men in comparison to the 'gender-neutral' average value. These differences amount to {+-}30% for coronary serial CT applications. (orig.) [German] Systematische geschlechtsabhaengige Unterschiede der Anatomie und Physiologie bleiben in der Standardmethodik zur Bestimmung der effektiven Dosis unberuecksichtigt. In dieser Arbeit werden drei Modelle zur Ableitung einer geschlechtsspezifischen effektiven Dosis dargestellt und bewertet. Mit dem sinnvollsten Ansatz ehaelt man - vor allem durch den Einfluss des Gewebe-Wichtungsfaktors fuer die Brust - fuer eine Thorax-CT-Serie eine geschlechtsspezifische effektive Dosis, die fuer die Frau um 11% hoeher und fuer den Mann 11% niedriger liegt als der Wert der 'geschlechtsneutralen' effektiven Dosis. Fuer eine Coronar-CT-Serie betragen die entsprechenden Abweichungen {+-}30%. (orig.)

  13. Pengaruh Waktu Aplikasi Dan Pemberian Berbagai Dosis Kompos Azolla (Azolla spp.) Terhadap Pertumbuhan Dan Produksi Tanaman Kailan (Brassica oleraceae Var. Acephala DC.)

    OpenAIRE

    Eko Andi Pasaribu

    2009-01-01

    Penelitian ini bertujuan untuk menguji pengaruh waktu aplikasi dan pemberian berbagai dosis kompos Azolla (Azolla spp.) terhadap pertumbuhan dan produksi tanaman kailan (Brasisca oleraceae Var. Acephala DC.). Penelitian dilaksanakan di lahan/areal percobaan Fakultas Pertanian Universitas Sumatera Utara Medan, dari bulan Juli 2008 sampai September 2008. Penelitian ini menggunakan Rancangan Acak Kelompok (RAK) faktorial dengan dua faktor perlakuan dan 3 ulangan. Fa...

  14. The DOSIS -Experiment onboard the Columbus Laboratory of the International Space Station -First Mission Results from the Active DOSTEL Instruments

    Science.gov (United States)

    Burmeister, Soenke; Berger, Thomas; Beaujean, Rudolf; Boehme, Matthias; Haumann, Lutz; Kortmann, Onno; Labrenz, Johannes; Reitz, Guenther

    Besides the effects of the microgravity environment, and the psychological and psychosocial problems encountered in confined spaces, radiation is the main health detriment for long dura-tion human space missions. The radiation environment encountered in space differs in nature from that on earth, consisting mostly of high energetic ions from protons up to iron, resulting in radiation levels far exceeding the ones encountered on earth for occupational radiation workers. Accurate knowledge of the physical characteristics of the space radiation field in dependence on the solar activity, the orbital parameters and the different shielding configurations of the International Space Station ISS is therefore needed. For the investigation of the spatial and temporal distribution of the radiation field inside the European COLUMBUS module the DLR experiment DOSIS (Dose Distribution Inside the ISS) was launched on July 15th 2009 with STS-127 to the ISS. The experimental package was transferred from the Space Shuttle into COLUMBUS on July 18th. It consists in a first part of a combination of passive detector packages (PDP) distributed at 11 locations inside the European Columbus Laboratory. The second part are two active radiation detectors (DOSTELs) with a DDPU (DOSIS Data and Power Unit) in a nomex pouch (DOSIS MAIN BOX) mounted at a fixed location beneath the European Physiology Module (EPM) inside COLUMBUS. After the successful installation the active part has been activated on the 18th July 2009. Each of the DOSTEL units consists of two 6.93 cm PIPS silicon detectors forming a telescope with an opening angle of 120. The two DOSTELs are mounted with their telescope axis perpendicular to each other to investigate anisotropies of the radiation field inside the COLUMBUS module especially during the passes through the South Atlantic Anomaly (SAA) and during Solar Particle Events (SPEs). The data from the DOSTEL units are transferred to ground via the EPM rack which is activated

  15. Lixiviación de potasio y contenidos nutrimentales en suelo y alfalfa en respuesta a dosis de vinaza

    OpenAIRE

    Patricia Flores Rodríguez; Francisco Gavi Reyes; Elibeth Torres Benites; Elizabeth Hernández Acosta

    2012-01-01

    Bajo condiciones de invernadero y con base a la concentración de potasio (K+) en la caracterización química de la vinaza, se evaluó el efecto de diferentes dosis (0, 250 y 500 kg ha-1de K+) sobre el suelo, en columnas de cloruro de polivinilo (PVC), empleando lisímetros de succión a dos profundidades (23 y 46 cm) y muestras al final de la columna (75 cm). En lixiviados se evaluó la concentración de K, el efecto sobre pH y conductividad eléctrica (CE), como cultivo indicador se uso alfalfa (Me...

  16. Lixiviación de potasio, contenidos nutrimentales en suelo y alfalfa en respuesta a dosis de vinaza.

    OpenAIRE

    Flores Rodríguez, Patricia

    2010-01-01

    Bajo condiciones de invernadero y con base a la concentración de potasio (K+) en la caracterización química de la vinaza, se evaluó el efecto de diferentes dosis (0, 250 y 500 kg ha-1 de K+) sobre el suelo, en columnas de cloruro de polivinilo (pvc), empleando lisímetros de succión a dos profundidades (23 y 46 cm) y muestras al final de la columna (75 cm). En lixiviados se evaluó la concentración de K, el efecto sobre pH y conductividad eléctrica (CE), como cultivo indicador se uso alfalfa ...

  17. Oorlewing van die skerpioen Opistophthalmus pugnax (Scorpionidae ná blootstelling aan ’n letale dosis SO2-gas

    Directory of Open Access Journals (Sweden)

    Willie J. van Aardt

    2013-02-01

    Full Text Available Skerpioene is bekend vir hul aanpasbaarheid by toestande in ’n droë habitat, min voedsel en radioaktiewe bestraling. Niks is bekend oor hul aanpasbaarheid by skadelike gasse nie. Resultate van hierdie eksperiment by Opistophthalmus pugnax bewys dat hulle ’n hoë dosis van 1000 dele per miljoen SO2 kan oorleef wat nie die geval is by die mens nie. Byvoorbeeld, die suurstofverbruikskoers neem eerder toe van 4.16 µmol/g-1 uur-1 na 7.69 µmol/g-1uur-1, een uur ná blootstelling aan SO2. Veertig minute na blootstelling was die ṀO2 steeds bykans twee keer hoër in vergelyking met die ṀO2 aan die begin. Hierdie bevinding moet deur verdere eksperimente nagevors word, veral wat die rol van spirakulumsluiting speel by blootstelling aan SO2.

  18. Respuesta de tres cultivares de maíz a la inoculación con Azospirillum brasilense bajo cuatro diferentes dosis de nitrógeno

    OpenAIRE

    Andrés González Huerta; Delfina de Jesús Pérez López; Omar Franco Mora; Artemio Balbuena Melgarejo; Francisco Gutiérrez Rodríguez; Heladio Romero Salas

    2011-01-01

    En el municipio de Huamuxtitlán, estado de Guerrero, México, se evaluó la respuesta de los materiales de maíz VS-535, H-507 y criollo veracruzano en las dosis de 0, 30, 60 y 90 kg de nitrógeno ha-1, con y sin Azospirillum brasilense. En el sintético VS- 535 se registró el mayor rendimiento de grano (5.23 t ha-1). En las dosis de 0, 30, 60 y 90 kg de N ha-1 se registraron 4.38, 4.36, 4.81 y 4.93 t ha-1, respectivamente. La diferencia entre aplicar o no Azospirillum brasilense (promedio sobre l...

  19. Uso eficiente del agua y producción óptima en maíz, con el uso de cuatro dosis de nitrógeno

    OpenAIRE

    Tomás Díaz Valdés; Leopoldo Partidas Ruvalcaba; Yolanda E. Suárez Fernández; Ramón Lizárraga Jiménez; Ángel López López

    2014-01-01

    La producción intensiva de maíz en zonas semiáridas se sustenta principalmente el agua y la fertilización nitrogenada, se busca hacer un manejo eficiente del agua y óptimo del nitrógeno (N), con la finalidad de mejorar el ingreso del productor y reducir la contaminación de las aguas subordinadas a las áreas agrícolas. El objetivo de este estudio fue determinar la eficiencia del uso del agua y la dosis óptima de nit rógeno mediante la aplicación de cuat ro dosis de N en maíz. El exper imento s...

  20. Evaluación de la toxicidad por dosis única y tolerancia local de la vacuna vax-SPIRAL® en ratas Sprague Dawley

    Directory of Open Access Journals (Sweden)

    Juan F. Infante

    2004-04-01

    Full Text Available Las pruebas preclínicas de toxicidad en dosis única y en dosis repetidas brindan una valiosa información sobre la seguridad del producto, al incluir el estudio macroscópico e histopatológico de órganos importantes, así como evaluaciones de las vías de administración y el régimen de dosificación. Cuba desarrolló una vacuna polivalente de células inactivadas químicamente adyuvadas con hidróxido de aluminio, vax-SPIRAL®. Esta vacuna presenta ventajas en relación con otras vacunas como la procedente de la antigua URSS. El esquema de vacunación para humanos consiste en dos dosis de 0,5 mL, separadas por un intervalo óptimo de seis semanas. El objetivo de este estudio de toxicidad en ratas Sprague Dawley fue determinar la toxicidad potencial, letalidad, órganos y sistemas susceptibles y otros eventos adversos, así como la toxicidad en el sitio de inoculación después de la administración de una dosis de la vacuna en estudio. Los resultados indicaron que, bajo las condiciones en estudio y según los criterios establecidos para evaluar los datos obtenidos, la vacuna antileptospirósica trivalente no produce efectos tóxicos en el modelo animal usado. Las únicas alteraciones encontradas fueron formaciones granulomatosas a nivel del sitio de inoculación. Estas formaciones han sido reportadas como pertenecientes al adyuvante de depósito (hidróxido de aluminio, también usado en otras vacunas de aplicación parenteral.

  1. Efecto de cinco Dosis de Heterorhabditis indica Poinat cepa P2M sobre la broca del café (Hypothenemus hampei Ferrari.

    Directory of Open Access Journals (Sweden)

    Yander Fernández Cancio

    2015-12-01

    Full Text Available Con el objetivo de evaluar el efecto de Heterorhaditis indica cepa P2M en el manejo de la broca del café (Hypotenemushampei Ferrari se realizó la investigación en condiciones controladas en el Laboratorio Provincial de Sanidad Vegetal de Sancti Spíritus con cinco dosis del patógeno: 20, 45, 75, 100 y 200 individuos juveniles infestiles/adulto (iji/adulto. Se diseñaron dos experimentos: variante 1 con aplicaciones directa sobre los adultos del insecto en placas Petri con siete repeticiones y variante 2 con la aplicación al suelo en bolsas de nylon con granos de la variedad Robusta con presencia de larvas y adultos del insecto. Se determinó la susceptibilidad de los adultos del insecto a las 24, 48 y 72 horas y el efecto de las dosis sobre el porcentaje de mortalidad de las larvas y adultos. Como resultado relevante de la variante 1 se destaca que los adultos tuvieron una susceptibilidad por encima del (50 % en 24 horas con las dosis superiores a 20 iji/adultos y en la variante 2 lo valores de mortalidad de las larvas fueron superiores a los adultos del insecto a las 72 horas. El nematodo constituye una alternativa viable en el control de la broca con valores de mortalidad de 50% en 24 horas.

  2. Estudio de toxicidad por dosis única y tolerancia local de una vacuna antimeningocócica tipo B en ratas Sprague Dawley

    Directory of Open Access Journals (Sweden)

    Juan F. Núñez

    2006-08-01

    Full Text Available La vacuna antimeningocócica tipo B, objetivo de este estudio, contiene vesículas purificadas de la membrana externa del meningococo del serogrupo B de la cepa (Cu- 385 - 83 B:4:P1.19,15. El esquema de vacunación propuesto en humanos consiste en tres dosis de 0,5 mL, separadas por un intervalo óptimo de ocho semanas. El objetivo de este estudio de toxicidad en ratas Sprague Dawley (SD fue determinar la toxicidad potencial, letalidad, órganos, sistemas susceptibles y otros eventos adversos, así como la toxicidad en el sitio de inoculación después de la administración de una dosis de la vacuna en estudio. Los resultados indicaron que, bajo las condiciones del estudio y según los criterios establecidos para evaluar los resultados, la vacuna antimeningocócica tipo B, no produce efectos tóxicos en el modelo animal usado. Todo lo que se observó fueron formaciones granulomatosas a nivel del punto de inoculación. Estas formaciones han sido reportadas como pertenecientes a los adyuvantes de depósito, como el hidróxido de aluminio, usado en otras vacunas parenterales. Se concluye que la vacuna antimeningocócica tipo B resultó satisfactoria en las pruebas de toxicidad por dosisúnica y tolerancia local realizadas en la especie rata.

  3. Dosis de Fitomas®-E para el enraizamiento de esquejes de guayaba var. Enana Roja Cubana

    Directory of Open Access Journals (Sweden)

    Leudiyanes Ramos-Hernández

    2014-01-01

    Full Text Available El ácido indol-acético ( aia es muy utilizado para enraizar esquejes de guayaba en Cuba. Se busca determinar el potencial del FitoMas ® -E como enraizador de esquejes de guayaba var. Enana Roja Cubana. La investiga - ción se llevó a cabo de 2009 a 2011 en Guantánamo, Cuba. Se utilizó diseño experimental completamente aleatorizado evaluando diferentes dosis de FitoMas ® -E (1-9 mL L - 1 , un testigo absoluto sin aplicación de productos y un testigo de producción de ácido indol acético a 5 mg L - 1 . El testigo de producción mostró 54.81% de eficiencia de enraizamiento, superior al FitoMas ® -E (5 mL L - 1 . Este último fue el más eficiente en el enraizamiento y mostró los mejores resultados en número de raíces y biomasa radical en esquejes de guayaba.

  4. Existe correlación entre la dosis de opioide y el tiempo de respuesta a metilnaltrexona Correlation between opioid dose and time response to methylnaltrexone

    Directory of Open Access Journals (Sweden)

    D. Chumpitaz-Corredor

    2012-02-01

    Full Text Available Introducción: el estreñimiento inducido por opioides tiene una prevalencia entre 20 y 80%, por lo que muchas veces se recurre al uso de laxantes profilácticos. Aproximadamente 80% de los pacientes con cáncer requerirá laxantes. Los opioides actúan sobre receptores localizados en las neuronas del sistema entérico, lo que conduce a estreñimiento mediante disminución de la peristalsis y las secreciones; metilnaltrexona (MTNX revierte este efecto. Objetivo: reportar el efecto de la administración de MTNX (12 mg vía subcutánea (SC para aliviar el estreñimiento inducido por opioides. Material y métodos: estudio retrospectivo, descriptivo, observacional realizado durante junio 2009 - abril 2010. Previa aprobación por el comité de ética de la institución se incluyeron 14 pacientes con estreñimiento inducido por opioides y que recibieron MTNX (12 mg SC en una o más dosis. Se analizaron las siguientes variables: edad, diagnóstico, opioide recibido (dosis equivalente a mg de morfina VO para 24 horas, número de días con estreñimiento, uso de laxantes, dosis adicionales de MTNX y efectos adversos. La correlación de las variables continuas se realizó con el coeficiente de correlación no paramétrico de Spearman. Resultados: el 100% (14 pacientes de la muestra evacuó posterior a la aplicación de MTNX en un promedio de 9 h 25 min. En cuanto a diagnóstico 78,5% tenían enfermedades oncológicas. La dosis de morfina VO en 24 horas, recibida por los pacientes al momento de la aplicación del medicamento en estudio, estuvo en un rango de 15 mg a 250 mg con promedio de 71,4 mg. Se encontró correlación positiva y significativa entre la dosis administrada de morfina y el tiempo entre administración subcutánea de MTNX y la primera evacuación (r = 1,000; p = 0,001. No hubo correlación entre la dosis administrada de morfina en 24 horas vía oral y los días de estreñimiento (r = - 0,195; p = 0,504; ni entre los días de estre

  5. PERUBAHAN NILAI NUTRIEN TANAMAN SORGUM (Sorghum bicolor (L. MOENCHVARIETAS LOKAL ROTE SEBAGAI HIJAUAN PAKAN RUMINANSIA PADA BERBAGAI UMUR PANEN DAN DOSIS PUPUK UREA

    Directory of Open Access Journals (Sweden)

    Bernadete B Koten

    2014-12-01

    Full Text Available Penelitian bertujuan untuk mengevaluasi perubahan nilai nutrien hijauan sorgum (Sorghum bicolor (L.Moench varietas lokal Rote sebagai pakan ternak ruminansia pada umur panen dan dosis urea yang berbeda,telah dilaksanakan di rumah kaca Laboratorium Hijauan Makanan Ternak dan Pastura Fakultas PeternakanUniversitas Gadjah Mada selama 4 bulan dari tanggal 11 November 2011 hingga 27 Februari 2012. Penelitianini dirancang dengan rancangan acak lengkap pola faktorial dengan 2 faktor perlakuan yaitu umur panen (UPsebagai faktor pertama (UP1= 50 hari, UP2 = 70 hari, dan UP3 = 90 hari dan dosis pupuk urea (P0 = tanpaurea sebagai kontrol, P1 = 50 kg/ha, dan P2 = 100 kg/ha sebagai faktor kedua. Kombinasi perlakuan inidiulang 4 kali. Variabel yang diamati adalah kadar bahan organik (BO, protein kasar (PK, serat kasar (SK,ekstrak eter (EE, bahan ekstrak tanpa N, dan kadar abu (% hijauan sorgum. Hasil penelitian menunjukkan bahwa kadar BO pada UP3P2, UP3P1 dan UP3P0 lebih tinggi dari perlakuan lainnya. Kadar PK tertinggi terdapat pada UP1P2 dan kadar EE tertinggi pada UP3P2. Kadar SK pada UP3P2 dan UP3P0 lebih tinggidan kadar BETN pada UP2P0 dan UP1P1 lebih tinggi dari perlakuan lainnya. UP1P0, UP1P1, dan UP1P2menghasilkan kadar abu yang lebih tinggi dari perlakuan lainnya. Disimpulkan bahwa umur panen 90 hariyang dikombinasikan dengan dosis urea 100 kg/ha menghasilkan nilai nutrien hijauan sorgum terbaik sebagaipakan ruminansia dengan 93,69% kadar BO, 04,45% kadar PK, 08,41% EE, dan 33,14% SK, 47,21% kadarBETN, dan 06,79% kadar abu. Kata kunci : Sorghum bicolor (L. Moench, hijauan pak

  6. Caracterización de un sistema de verificación de dosis dedicado a tratamientos de radioterapia basado en un detector de tiras de silicio

    OpenAIRE

    Bocci, A.; Córtes-Giraldo, M. A.; Espino, J. M.; Alvarez, M.A.G.; Abou-Haidar, Ziad

    2011-01-01

    [ES]: El objetivo de este trabajo es la caracterización de un detector de tiras de silicio y del sistema de adquisición de datos, basado en electrónica discreta. Este sistema, una vez validado, será la base de una nueva técnica de obtención de mapas de dosis en planos axiales útiles para la verificación de tratamientos de radioterapia. El dispositivo experimental se basa en el detector montado en dos maniquíes diseñados para este estudio: uno plano y uno cilíndrico, que se irradian con un lin...

  7. Factores que afectan la producción de dosis de semen en centros de inseminación artificial porcina

    OpenAIRE

    Rocha, G.; Castañeda, J.; Valencia, J. J.

    2005-01-01

    Con el fin de determinar los factores que influyen en la producción de dosis de semen de calidad, se llevó a cabo el presente trabajo en centros de producción intensiva de semen. Un total de 8,420 eyaculados provenientes de 97 sementales alojados en dos diferentes postas del centro de la República Mexicana fueron evaluados para determinar sus parámetros de producción. De acuerdo a los datos analizados, la edad máxima en la que un semental puede ser utilizado para la colección de semen es de 3...

  8. Farmacocinética comparativa de una dosis única de ampicilina en llamas luego de la administración intravenosa, intramuscular y subcutánea

    OpenAIRE

    V Kreil; AP Prados; Ambros, L.; A Monfrinotti; P Quaine; R HALLU; M Rebuelto

    2014-01-01

    Los objetivos de este estudio fueron describir y comparar la farmacocinética y biodisponibilidad de la ampicilina administrada por las vías intravenosa (i.v.), intramuscular (i.m.) y subcutánea (s.c.) a llamas (Lama glama) adultas sanas, y calcular los correspondientes tiempos sobre la CIM (T > CIM) a fin de proveer una base farmacológica para la terapia antimicrobiana racional en esta especie. Seis llamas recibieron una dosis de ampicilina por las vías i.v., i.m. y s.c. Se extrajo sangre a t...

  9. Evaluación de la toxicidad aguda por el procedimiento de dosis fijas de un extracto de Boldoa purpurascens Cav. (Evaluation of the acute toxicity of the method fixed dose procedure of an extract of Boldoa prurpurascens Cav.)

    OpenAIRE

    Pérez Machín, Maykel; Monteagudo Jiménez, Emilio E; Boffill Cárdenas, María de los Ángeles; Méndez Triana, Rayza; Verdecía Machado, Belkys

    2008-01-01

    ResumenSe realizó un estudio experimental con el objetivo de evaluar el posible efecto tóxico de un extracto acuoso liofilizado de Boldoa purpurascen Cav. (nitro blanco). Para el desarrollo del mismo se utilizó el Procedimiento de Dosis Fijas (FDP), utilizando una dosis límite de 2000 mg/kg de peso corporal. Los animales seleccionados fueron ratas de la línea Sprague Dawley, con un peso comprendido entre 150 y 200 g. Los resultados demostraron la inocuidad de la planta al no observarse signo...

  10. INFLUENCIA DE LAS MICORRIZAS ARBUSCULARES EN COMBINACIÓN CON DIFERENTES DOSIS DE FERTILIZANTE MINERAL EN ALGUNAS CARACTERÍSTICAS MORFOLÓGICAS DE LAS PLÁNTULAS DE TABACO

    OpenAIRE

    Yoanna Cruz Hernández; Milagro García Rubido; Yarilis León González; Juan M. Hernández Martínez

    2012-01-01

    En la Estación Experimental del Tabaco, San Juan y Martínez, Pinar del Río, se desarrolló una investigación durante las campañas tabacaleras 2005-2006 y 2006-2007, con el objetivo de determinar la influencia de la combinación de las micorrizas y dos dosis de fertilizante mineral, en semilleros con la variedad 'Corojo 99'. Se utilizó un diseño de bloques al azar con seis tratamientos y cuatro réplicas. Los resultados demostraron que se logra reducir la dosis de fertilizante mineral sin afec...

  11. Efecto de diferentes dosis de aspirina sobre el precondicionamiento contra el atontamiento en ovejas Effect of different doses of aspirin on preconditioning against stunning in conscious sheep

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    Elena C. Lascano

    2004-02-01

    Full Text Available Se ha postulado que los antiinflamatorios no esteroides que actuan inhibiendo la ciclooxigenasa (COX podrían tener efectos nocivos sobre el corazón. Recientemente se ha demostrado que los inhibidores de la COX-2 bloquean la protección por precondicionamiento tardío (PT. Se desconoce sin embargo, el efecto que pudiera tener la aspirina, el antiinflamatorio no esteroide más ampliamente utilizado en la clínica, sobre el PT en mamíferos grandes. La aspirina actúa inhibiendo las dos isoenzimas de la ciclooxigenasa (COX-1 y COX-2, siendo empleada en dosis altas como droga antiinflamatoria y en dosis bajas como agente antitrombótico. El propósito de este estudio fue analizar qué efecto tienen distintas dosis de aspirina sobre la protección del PT contra el atontamiento y las arritmias en ovejas conscientes. Se consideraron 5 grupos; control (C: 12 min de isquemia (I y 2 hr de reperfusión (R; PT: 6 períodos de 5 min I-5 min R, 24 hr antes de la I de 12 min, y tres grupos igual que PT, pero con 1.5 (PTA1.5, 8 (PTA8 y 20 (PTA20 mg/kg de aspirina respectivamente, administrados 10 min antes de la primera I de precondicionamiento. Los resultados demostraron que la dosis antiinflamatoria de aspirina (20 mg/kg fue capaz de inhibir el PT contra el atontamiento (C vs PTA20, NS, mientras que las dosis bajas (1.5 mg/kg e intermedia (8 mg/kg no afectaron la protección (C vs PT, PT1.5 y PT8, pNon-steroid antiinflammatory drugs, inhibitors of cyclooxigenase (COX, have been postulated to have deletereous effects on the heart. Recently, COX-2 inhibitors have also been found to block late preconditioning (LP protection. Aspirin is the most widely clinically used non-steroid antiinflammatory drug; yet its effect on LP in big mammals has not been determined. It inhibits the two cyclooxigenase isoenzymes (COX-1 and COX-2, at high doses being used as an antiinflammatory drug and at low doses as an antithrombotic agent. The goal of this study was thus, to

  12. Terapeutica de enfermagem nos casos de prolapso uterino

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    Elaine Blanco Rodrigues

    1990-12-01

    Full Text Available Trabalho realizado no Hospital Universitário "Pedro Ernesto" UERJ. Comenta as ações de enfermagem na assistência a pacientes portadoras de prolapso uterino. Apresenta considerações sobre o problema e ilustra a proposta terapêutica de enfermagem com a descrição de três casos.

  13. Controllable dose; Dosis controlable

    Energy Technology Data Exchange (ETDEWEB)

    Alvarez R, J.T.; Anaya M, R.A. [ININ, A.P. 18-1027, 11801 Mexico D.F. (Mexico)]. E-mail: jtar@nuclear.inin.mx

    2004-07-01

    With the purpose of eliminating the controversy about the lineal hypothesis without threshold which found the systems of dose limitation of the recommendations of ICRP 26 and 60, at the end of last decade R. Clarke president of the ICRP proposed the concept of Controllable Dose: as the dose or dose sum that an individual receives from a particular source which can be reasonably controllable by means of any means; said concept proposes a change in the philosophy of the radiological protection of its concern by social approaches to an individual focus. In this work a panorama of the foundations is presented, convenient and inconveniences that this proposal has loosened in the international community of the radiological protection, with the purpose of to familiarize to our Mexican community in radiological protection with these new concepts. (Author)

  14. Tratamiento con altas dosis de corticoides de Púrpura Trombocitopénica Inmune en paciente con Diabetes Mellitus y Obesidad Mórbida, un desafio metabólico

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    Juan Pedro Andreu Cuello

    2012-06-01

    Full Text Available El manejo de la púrpura trombocitopénica inmune con altas dosis de corticoides en pacientes con diabetes mellitus y obesidad mórbida no está definido. Mujer de 64 años con obesidad mórbida, diabetes mellitus 2 y púrpura trombocitopénico inmune presenta trombocitopenia severa de 2 000 plaquetas asociada a equimosis extensas en ambas extremidades inferiores y glicemia descompensada. Se inició tratamiento con Metilprednisolona 500mg por tres días y luego Prednisona 60mg/día, al quinto día se aumentó dosis a 110mg/día. Se usó Metformina (850mg, tres veces al día, insulina NPH e insulina cristalina, logrando pasar de una glicemia capilar promedio de 322mg/dl (primer día a 122mg/dl (decimotercer día. Al decimocuarto día, con 86 000 plaquetas, fue dada de alta con tratamiento vía oral y control en policlínico. Se logró compensación metabólica con altas dosis de insulina NPH y Metformina. Es posible usar altas dosis de corticoides en pacientes con diabetes mellitus 2 y obesidad mórbida

  15. Evaluación de mezclas formuladas de fertilizantes con dosis crecientes y aplicación de materia orgánica en el rendimiento de tabaco negro en un suelo arenoso bajo condiciones de invernadero

    Directory of Open Access Journals (Sweden)

    Aníbal Cóndor G

    2013-06-01

    Full Text Available El presente trabajo compara tres mezclas formuladas de fertilizantes —una mezcla tradicional; un fertilizante mineral 10-15-20; y un fertilizante orgánico-mineral 8-12-16 en dosis crecientes, con y sin aplicación de materia orgánica (humus de lombriz— en el cultivo de tabaco. El experimento se condujo en un suelo arenoso de irrigación utilizando 2 plántulas de tabaco negro por maceta. La fertilización al suelo para cada dosis de NPK en mg.kg-1/maceta fue: dosis baja (160-60-80, dosis media (320-120-160 y dosis alta (480-180-240. Se utilizó el diseño completo al azar con arreglo factorial, con tres repeticiones y conducido en macetas con 4 kg de suelo. La evaluación consistió en medir el rendimiento en peso fresco de la parte aérea y el peso seco total (parte aérea y radicular de las plantas. Fue posible observar que no existe superioridad en cuanto a la materia fresca y seca total producidas entre las mezclas formuladas utilizadas, con un promedio de 432,5g/maceta y 112,6g/ maceta, respectivamente. Se pudo tener así tres alternativas en la fertilización de tabaco. Sin embargo, con el uso del fertilizante orgánico-mineral se obtendría mayores beneficios en el suelo por el efecto residual que dejaría por contener en su composición un 25% de materia orgánica por cada 100 kg de fertilizante. Conforme aumentan las dosis de fertilización se incrementan también los rendimientos, notándose el efecto directo de los fertilizantes en el sustrato arenoso utilizado, sin salinidad que pueda haber afectado la asimilación de nutrientes. Además, se observó la baja fertilidad del sustrato al comparar el tratamiento adicional 0-0-0 con los demás tratamientos, lo que ha producido mas del 300% en cuanto a rendimiento. No existe efecto significativo en la interacción fertilizante vs. materia orgánica en la producción de materia fresca aérea y seca total, debido a que la dosis de materia orgánica fue baja (1%.

  16. Estatinas para el Síndrome Coronario Agudo Medicina basada en evidencia sobre la administración temprana con dosis de carga

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    Carlos Fonseca-Gamboa

    2011-09-01

    Full Text Available Objetivo: En algunos Servicios de Emergencias de la CCSS, a los pacientes con infarto agudo de miocardio se les administra una dosis alta -aunque variable- de lovastatina en las primeras horas de evolución de los síndromes coronarios agudos, con la expectativa de lograr efectos pleiotrópicos, un resultado positivo sobre el endotelio y la disminución de mediadores inflamatorios. Analizar la evidencia científica que sustenta el beneficio de esta intervención farmacológica y clarificar la posible dosis oral y el potencial intervalo idóneo. Búsqueda vía electrónica en sistemas secundarios de información científica y análisis de fuentes primarias, con énfasis en ensayos clínicos aleatorizados que evalúen la eficacia de las estatinas en los eventos coronarios agudos; también de fuentes terciarias, específicamente revisiones sistemáticas y guías de consenso para práctica clínica basadas en evidencia y revisiones por instancias evaluadoras de tecnologías con reconocimiento internacional. Resultados: Cuatro ensayos clínicos aleatorizados controlados con placebo, no demostraron diferencias significativas ni clínicamente relevantes en la variable primaria combinada: evento cardiaco mayor, muerte, IAM recurrente fatal, AVC fatal u otra causa de muerte cardiovascular, ninguno usó dosis de carga, ni se inició la administración en las 24 hs del inicio de la sintomatología. Conclusión: Ante la falta de evidencia que permita proyectar con claridad un papel beneficioso para las estatinas en el manejo inicial del síndrome coronario agudo, esta práctica desequilibra la relación beneficio/riesgo y se aleja de los principios del uso racional de medicamentos y la aplicación del paradigma de la medicina basada en evidencia.

  17. Ajuste rápido de dosis de tapentadol en el tratamiento del dolor mal controlado Fast titration of tapentadol for the treatment of badly controlled pain

    OpenAIRE

    M. J. Sánchez del Águila; R. González López; A. D. Ballesteros Chaves; F. Robles Domínguez; L. F. Valdés Vilches; P. Alonso Atienza

    2012-01-01

    Introducción: el tapentadol es un nuevo fármaco de acción dual MOR/NRI, que actúa a nivel central, efectivo en el tratamiento del dolor moderado e intenso, que presenta un perfil de tolerabilidad mas favorable que otros opiáceos. Esto podría permitir una titulación rápida que permita un control precoz del dolor. Material y métodos: presentamos dos casos clínicos en los que se realiza una titulación rápida de la dosis de tapentadol en pacientes hospitalizados con dolor mal controlado. Este aju...

  18. Evaluación de la toxicidad por dosis única de la vacuna antitetánica vax-TET en ratas Sprague Dawley

    OpenAIRE

    2007-01-01

    La vacuna vax-TET® está indicada en la prevención del tétanos y es efectiva si se logra un completo y apropiado esquema de inmunización. Para investigar el potencial tóxico de este producto se realizó una prueba toxicológica con una dosis única, por vía intramuscular, en un volumen de 0,2 mL en ratas Sprague Dawley. La composición de la vacuna de ensayo probada fue la misma de la vacuna comercial. Los animales fueron observados diariamente en busca de síntomas locales y sistémicos de toxicida...

  19. Compuestos nitrogenados indicadores de estrés en respuesta a las dosis tóxicas y deficientes de Nitrógeno en frijol ejotero

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    Esteban Sánchez

    2016-01-01

    Full Text Available Introducción: Un amplio rango de estreses ambientales, tales como baja temperatura, sequía, alcalinidad, salinidad, deficiencia y toxicidad de nutrientes son potencialmente dañinos para las plantas. El papel del nitrógeno como nutriente esencial y componente estructural de aminoácidos, proteínas, ácidos nucleicos y otros constituyentes esenciales para el desarrollo ha sido ampliamente documentado en varias especies debido a la importancia en los procesos de crecimiento y producción agrícola. Sin embargo, en la actualidad, existe escasa literatura del efecto de la deficiencia y toxicidad de nitrógeno sobre los compuestos osmoreguladores como indicadores de estrés en plantas. Por lo que el objetivo del presente trabajo fue estudiar los compuestos nitrogenados indicadores de estrés (prolina, glicinabetaina y colina en respuesta a las dosis tóxicas y deficientes de N en frijol ejotero desarrollado en cámara de cultivo bajo condiciones controladas y sistema hidropónico. Método: El nitrógeno fue aplicado a la solución nutritiva en la forma de NH4NO3 y en dosis crecientes: N1 = 1.5 mM, N2 = 3.0 mM, N3 = 6.0 mM, N4 = 12.0 mM, N5 = 18.0 mM y N6 = 24.0 mM de N. Los parámetros analizados fueron la acumulación de biomasa, la concentración de prolina, glicinabetaina y colina en hojas, raíces, semillas y vainas de frijol ejotero cv. Strike. Resultados: La aplicación de dosis deficientes y tóxicas de N afectó la producción de biomasa en frijol, siendo las dosis tóxicas las que afectaron más este parámetro. Por otro lado, resaltar que los osmoreguladores prolina, glicinabetaina y colina solamente se acumularon bajo condiciones de toxicidad de N (N6, sin embargo, en condiciones de estrés provocado por la deficiencia de N (N1 no se produce la acumulación de estos compuestos. Discusión o Conclusión: Los compuestos nitrogenados indicadores de estrés solamente se acumulan bajo condiciones de toxicidad de N (N6, sin embargo en

  20. Toxicidad por dosis repetidas de la solución CM-95 tratada magnéticamente en ratas Sprague Dawley

    OpenAIRE

    Martínez, Clara E.; Jorge Díaz; Alfredo Alfonso; Ana M. Pardo; Juan Esmérido Betancourt; Edgar Puente; Hilario Salas; Yoandra Mora; Petra Aguilera; Narvis Sedeño; Eblis Aguilera; Karina Rojas; Anoy Rodríguez; Gustavo Sierra

    2008-01-01

    En este trabajo se realizó la evaluación toxicológica a dosis repetidas por el método de test límite del candidato a inmunopotenciador, la solución CM-95 tratada magnéticamente, acorde con las regulaciones de la Organización para la Colaboración Económica y el Desarrollo, incluida en la Guía 407. El objetivo fue establecer las posibles lesiones orgánicas y funcionales ocasionadas por la solución CM-95, tratada magnéticamente con la máxima inducción magnética permisible (0,16 T), para la obten...

  1. Ajuste rápido de dosis de tapentadol en el tratamiento del dolor mal controlado Fast titration of tapentadol for the treatment of badly controlled pain

    Directory of Open Access Journals (Sweden)

    M. J. Sánchez del Águila

    2012-02-01

    Full Text Available Introducción: el tapentadol es un nuevo fármaco de acción dual MOR/NRI, que actúa a nivel central, efectivo en el tratamiento del dolor moderado e intenso, que presenta un perfil de tolerabilidad mas favorable que otros opiáceos. Esto podría permitir una titulación rápida que permita un control precoz del dolor. Material y métodos: presentamos dos casos clínicos en los que se realiza una titulación rápida de la dosis de tapentadol en pacientes hospitalizados con dolor mal controlado. Este ajuste rápido, permitió controlar el dolor, en ausencia de efectos secundarios, acortando el tiempo de estancia hospitalaria de estos pacientes. Conclusiones: el perfil favorable de efectos secundarios mostrado por el tapentadol, permite un ajuste rápido de la dosis, que consigue un control eficaz del dolor en un menor lapso de tiempo.Background: tapentadol is a new drug with a centrally acting, dual action mechanism on MOR/NRI. It is effective on moderate to severe pain and shows a favourable side effects profile in comparison to other major opiates. This could allow a fast dose titration to achieve an earlier pain control. Material and methods: we present two cases on which we have performed a fast dose titration in hospitalised patients with bad pain control. This fast titration allowed an early control of the pain, in absence of side effects, achieving a shortening in their hospital stay. Conclusions: the favourable side effects profile of tapentadol, allows a fast dose titration, achieving an efficacious pain control in a shorter time lapse.

  2. Toxicidad por dosis repetidas de la solución CM-95 tratada magnéticamente en ratas Sprague Dawley

    Directory of Open Access Journals (Sweden)

    Clara E. Martínez

    2008-08-01

    Full Text Available En este trabajo se realizó la evaluación toxicológica a dosis repetidas por el método de test límite del candidato a inmunopotenciador, la solución CM-95 tratada magnéticamente, acorde con las regulaciones de la Organización para la Colaboración Económica y el Desarrollo, incluida en la Guía 407. El objetivo fue establecer las posibles lesiones orgánicas y funcionales ocasionadas por la solución CM-95, tratada magnéticamente con la máxima inducción magnética permisible (0,16 T, para la obtención del candidato a inmunopotenciador. Se emplearon tres grupos: Experimental, Control y Satélite. Como Biomodelo experimental se utilizaron ratas Sprague Dawley machos y hembras con pesos de 150 a 200 g. Durante el estudio no se registraron signos clínicos de toxicidad ni muertes en ninguno de los animales de los grupos tratados, ni en los controles. No hubo afectación del peso corporal durante el ensayo. Aunque hubo variaciones en los valores de algunos parámetros hematológicos y bioquímicos, estos no tuvieron significación biológica. No se encontraron lesiones macroscópicas, ni microscópicas; solo se observaron efectos proliferativos en el tejido linfoide de timo y bazo, relacionados con la respuesta del sistema inmune. La solución CM-95 tratada magnéticamente, no mostró toxicidad en el modelo animal y nivel de dosis utilizado, y bajo las condiciones experimentales ensayadas.

  3. Eficacia del Albendazol en dosis única sobre las infecciones por helmintos transmitidos por el suelo en escolares de una comunidad de Iquitos, Perú

    Directory of Open Access Journals (Sweden)

    Theresa W Gyorkos

    2013-10-01

    Full Text Available Objetivos. Determinar la eficacia en dosis única del albendazol sobre las infecciones por helmintos transmitidos por el suelo (HTS en escolares de una comunidad de la ciudad de Iquitos en Perú. Materiales y métodos. Dentro del contexto de un ensayo controlado aleatorizado realizado en una comunidad periurbana de escasos recursos, situada en Iquitos, en la Amazonía de Perú, se obtuvieron muestras de heces de escolares del quinto grado de primaria en 18 escuelas y se analizó la prevalencia y la intensidad de HTS. Un total de 1193 escolares fueron desparasitados con albendazol en dosis única (400 mg. De los 909 escolares que fueron encontrados positivos con al menos una infección por HTS, una muestra aleatoria de 385 fue seguida dos semanas más tarde, cuando se recolectó y analizó una segunda muestra de heces. Resultados. La eficacia del albendazol fue satisfactoria para las infecciones por Ascaris lumbricoides con una tasa de reducción de huevos (TRH de 99,8%; IC 95: 99,3-100 y por anquilostomideos con una TRH de 93,6%, IC 95%: 88,2-96,6 y por Trichuris trichiura con una TRH de 72,7%, IC 95: 58,5-79,1. Conclusiones. Estos resultados son indicativos de niveles satisfactorios de eficacia y son congruentes con datos publicados sobre la eficacia del albendazol y directivas de la Organización Mundial de la Salud. Futuras investigaciones deben centrarse en mejorar la eficacia de las estrategias de tratamiento para la infección por Trichuris trichiura.

  4. Factores que afectan la producción de dosis de semen en centros de inseminación artificial porcina

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    G. Rocha

    2005-01-01

    Full Text Available Con el fin de determinar los factores que influyen en la producción de dosis de semen de calidad, se llevó a cabo el presente trabajo en centros de producción intensiva de semen. Un total de 8,420 eyaculados provenientes de 97 sementales alojados en dos diferentes postas del centro de la República Mexicana fueron evaluados para determinar sus parámetros de producción. De acuerdo a los datos analizados, la edad máxima en la que un semental puede ser utilizado para la colección de semen es de 36 meses y su ritmo de colección en la edad adulta es de una vez cada 5 días. Se encontró también que existe una moderada correlación negativa, entre temperatura ambiental y número de dosis obtenidas de cada semental (r = -0.534, P< .05. Por otro lado, se encontró una capacidad de producción dependiente de la línea genética, siendo los híbridos de Seghers los más productivos contra los sementales de la línea PIC, que resultaron con baja producción de semen. Otros parámetros analizados, fueron las causas de desecho de los sementales, siendo la principal la baja calidad de los eyaculados (hasta un 44.11%, seguido por edad avanzada (29%, problemas varios (atrofia de pene, uretra, entre otros: 12% y problemas de locomoción (6%. Los datos aquí encontrados permiten establecer estrategias para optimizar la producción de semen en las postas de sementales

  5. DETERMINACIÓN DE UN MÉTODO DE CALCULO DE DOSIS GLANDULAR PROMEDIO EN EXAMENES DE MAMOGRAFIA CONVENCIONAL DETERMINATION OF A METHOD FOR CALCULATING MEAN GLANDULAR DOSE IN CONVENTIONAL MAMMOGRAPHY EXAMS

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    Oswaldo Ramos N; Manuel Villarreal U

    2009-01-01

    Presentamos la aplicación de un modelo numérico para estimarla dosis glandular promedio en mamografía. Hemos utilizado un mamógrafo General Electric, tensión del tubo: 20-35 kV con incrementos de 1 kV; carga del tubo: 10-250 mAs; combinación ánodo-filtro de Molibdeno-Molibdeno. Durante dos meses datos de 162 exploraciones con proyecciones cráneo-caudal y medio lateral oblicua en ambas mamas. El espesor de mama comprimida se encuentra en el rango de 2,5 a 6,5 cm. Los rangos de dosis glandular ...

  6. Dosis óptima económica de nitrógeno en maíz bajo siembra directa en el sudeste bonaerense Economic optimal nitrogen rate for corn under no-tillage in southeast Buenos Aires Province

    OpenAIRE

    A. Pagani; HE Echeverría; HR Sainz Rozas; PA Barbieri

    2008-01-01

    La fertilización nitrogenada en el cultivo de maíz es una práctica habitual en el SE bonaerense, sin embargo es escasa la información local para definir la dosis de nitrógeno (N) que responde al máximo beneficio económico. El objetivo de este trabajo fue determinar la dosis óptima económica (DOE) del fertilizante nitrogenado para el cultivo de maíz bajo SD en el SE bonaerense, seleccionando el modelo matemático y momento de fertilización más adecuado. Además, se comparó el efecto de la relaci...

  7. Comunicato stampa della IARC N°238: "L’ ESPOSIZIONE A BASSE DOSI DI RADIAZIONI IONIZZANTI AUMENTA IL RISCHIO DI MORTE A CAUSA DI TUMORI SOLIDI". Pubblicato il 21 ottobre 2015

    OpenAIRE

    Fellone, Lucio

    2016-01-01

    Versione autorizzata in italiano del Comunicato Stampa della IARC N°238 pubblicato il 21 ottobre 2015: "L’ ESPOSIZIONE A BASSE DOSI DI RADIAZIONI IONIZZANTI AUMENTA IL RISCHIO DI MORTE A CAUSA DI TUMORI SOLIDI". Documento originale all'indirizzo: http://www.iarc.fr/en/media-centre/pr/2015/pdfs/pr238_E.pdf Authorized Italian version of the IARC Press Release N°238 published on 21 October 2015: Low doses of ionizing radiation increase risk of death from solid cancers...

  8. Exposición a dosis bajas de radiación ionizante en el Hospital Universitario del Valle, Cali, 1980-1992.

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    Rafael Caicedo

    2009-10-01

    Full Text Available Se realizó este estudio de cohorte analítica histórica entre 1980 y 1992, con el objeto de describir el estado de salud de los técnicos de rayos X, expuestos a dosis bajas de radiación ionizante, y compararlos con un grupo no expuesto, seleccionado al azar entre auxiliares de enfermería del Hospital Universitario del Valle (HUV. Se basó en las ausencias laborales como una aproximación a la morbilidad real. Los técnicos de rayos X del HUV, mostraron un "efecto protector" (IRR 0.43, IC 95% 0.34-0.55, con diferencias significativas entre causas quirúrgicas y las denominadas "otras." Se plantea la hipótesis acerca del estrés psicosocial como generador de estas diferencias en el grupo no expuesto. Se destaca la necesidad de realizar procedimientos administrativos en hojas de vida, historias clínicas y dosimetrías, para poder contar hacia el futuro con herramientas sólidas.

  9. Risks of low dose ionising radiation exposures Riesgos derivados de la exposición a dosis bajas de radiación ionizante

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    Almudena Real Gallego

    2010-12-01

    Full Text Available Although ionising radiation has been shown to have several beneficial applications for humans, it can also produce detrimental effects in humans and the environment. To adequately protect man and environment from the potential harmful effects of ionising radiation, is essential to know in detail the biological effects produced by it, its characteristics and the various factors that influence these effects. That is the objective of this article, describe the current status of knowledge about biological effects induced by ionising radiation, with special emphasis on those effects occurring after low dose exposures.La radiación ionizante ha mostrado tener diversas aplicaciones beneficiosas para el hombre, pero también puede dañar la salud de las personas y el medio ambiente. Para proteger adecuadamente al hombre de los posibles efectos nocivos de la radiación ionizante es imprescindible conocer en detalle los efectos biológicos producidos por esta, sus características y los distintos factores que influyen en dichos efectos. Ese es el objetivo de este artículo: describir el estado actual del conocimiento sobre los efectos biológicos que puede producir la radiación ionizante, con especial énfasis en aquellos efectos que se producen tras la exposición a dosis bajas.

  10. Dosis elevadas de aspirina disminuyen la natriuresis en hipertensos tratados con enalapril High doses of aspirin reduce natriuresis in hypertensive patients treated with enalapril

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    Federico P. Di Gennaro

    2004-08-01

    Full Text Available Los inhibidores de la enzima convertidora de la angiotensina (IECA han demostrado ser eficaces en el tratamiento de la hipertensión arterial. Sin embargo, una importante proporción de hipertensos recibe además antiagregación plaquetaria con ácido acetil salicílico (AAS, y la consecuente inhibición de la síntesis de prostaglandinas con AAS atenuaría el efecto vasodilatador y la mayor excreción urinaria de sodio (Na u atribuidas al IECA. Nuestro objetivo fue evaluar la interacción de dos dosis de AAS (81 y 325 mg/día sobre el efecto hipotensor del enalapril y el impacto sobre la excreción de Na u en pacientes hipertensos. Se incluyeron 22 pacientes de ambos sexos, entre 35 y 65 años. Todos recibieron enalapril, dieta hiposódica y, secuencialmente separadas por período de «wash out», las dos dosis de AAS durante los setenta días del estudio. Se evaluó: presión arterial sistólica (PAS, diastólica (PAD, media (PAM y Na u en un período basal (PB, con 325 y 81 mg de AAS (P1 y P2 respectivamente. Comparando el PB con P1 y P2, se observó una reducción significativa de la PAS, PAD, PAM (pAngiotensin converting enzyme inhibitors have been shown to be useful in the treatment of essential hypertension while anti-platelet agents improve the overall cardiovascular risk profile in this population. Our aim was to assess the interaction of two different aspirin (ASA doses -81 and 325 mg/day- with the antihypertensive effect of enalapril as well as their impact upon the urinary sodium excretion (Na u. A total of 22 patients between 35 and 65 years of age were included in a prospective double blind trial with a partial cross-over design. We excluded patients with secondary hypertension and recent use of anti-inflammatory drugs. Patients were placed on enalapril and a low sodium diet -<6 g of NaCl/day- and, sequentially, on two different doses of aspirin separated by a 10 day wash out period. Blood pressure (BP was measured at weekly visits

  11. Efecto de una sola dosis de ácido zoledrónico en un caso de enfermedad de Paget ósea

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    Melina Sabán

    2010-10-01

    Full Text Available La enfermedad de Paget es un trastorno crónico del remodelado óseo, caracterizado por un aumento de la resorción ósea producido por osteoclastos atípicos, seguido por un incremento acelerado de la formación ósea, lo que resulta en la formación de hueso en mosaico desorganizado. Un excelente marcador bioquímico para orientar el diagnóstico y seguimiento es la fosfatasa alcalina (FAL. Se presenta el caso de un paciente de 90 años, de sexo masculino, con diagnóstico de enfermedad de Paget. Se inicia tratamiento con pamidronato vía oral con respuesta parcial, por lo que se rota a pamidronato endovenoso. Disminuyen el dolor y la concentración plasmática de FAL, persistiendo con centellograma óseo patológico. Luego de varios años de tratamiento, con adecuado aporte de calcio y vitamina D, comienza nuevamente con dolor y valores elevados de FAL. Se decide iniciar tratamiento con ácido zoledrónico endovenoso 4 mg, única aplicación, obteniéndose remisión clínica y bioquímica desde hace cuatro años y mejoría de la imagen centellográfica. Este informe refiere la buena respuesta, sostenida en el tiempo, al tratamiento con única dosis de ácido zoledrónico en un paciente que presentó resistencia al pamidronato.

  12. Evaluación de la toxicidad por dosis única de la vacuna antitetánica vax-TET en ratas Sprague Dawley

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    Yulieé López.

    2007-12-01

    Full Text Available La vacuna vax-TET® está indicada en la prevención del tétanos y es efectiva si se logra un completo y apropiado esquema de inmunización. Para investigar el potencial tóxico de este producto se realizó una prueba toxicológica con una dosis única, por vía intramuscular, en un volumen de 0,2 mL en ratas Sprague Dawley. La composición de la vacuna de ensayo probada fue la misma de la vacuna comercial. Los animales fueron observados diariamente en busca de síntomas locales y sistémicos de toxicidad. Se realizaron mediciones del consumo de agua y alimento, así como del peso corporal. Dos semanas después de la inoculación las ratas fueron sacrificadas por métodos de eutanasia sin dolor y sometidas a necropsia. No se observaron muertes ni síntomas de toxicidad en los animales estudiados. Tampoco se encontraron diferencias de interés toxicológico entre los grupos experimentales en cuanto a las variables medidas. El estudio anatomopatológico reveló la presencia de formaciones granulomatosas de tipo macrofágico asociadas, fundamentalmente, al hidróxido de aluminio. Estos resultados permitieron concluir que, bajo las condiciones del estudio y según los criterios establecidos, esta vacuna no produce efectos adversos en el modelo animal usado, por lo que se considera potencialmente no tóxica para humanos.

  13. Dosis elevada en el dosímetro personal de una auxiliar de enfermería en Electrofisiología A high dose in the personal dosage meter of nursing assistant in Electrophysiology field

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    Raquel Barquero Sanz

    2012-03-01

    Full Text Available En una sala de Electrofisiología del Servicio de Cardiología en donde se efectúan procedimientos guiados con rayos X de ablación con radiofrecuencia y de implantes de desfibrilador biventricular, se registraron dosis mensuales anormalmente elevadas en el dosímetro personal de solapa de una auxiliar de enfermería que trabaja en la misma, con valores de dosis equivalente personal, Hp(10, de 125 mSv y de dosis equivalente personal superficial, Hp(0.07 de 128.1 mSv. Ante la ansiedad producida en la trabajadora al conocer las lecturas de su dosímetro, y dado que no se dispone de precedentes investigados en la instalación, se ha realizado un estudio para dilucidar si la dosis registrada ha podido ser recibida por la trabajadora o si solo ha sido recibida por el dosímetro. Se hacen medidas con un monitor ambiental en condiciones simuladas de los procedimientos, para estimar las dosis reales que pueda recibir el personal de la sala. Se comparan estos valores con los del rendimiento del equipo de RX en haz directo medidos durante la revisión anual de control de calidad del mismo, concluyéndose que ha sido el dosímetro, y no la trabajadora, el que se ha expuesto a radiación directa, siendo la situación más probable la de que dicho dosímetro cayó sobre el tubo de RX, normalmente orientado hacia el techo, un tiempo del orden de 1 minuto. Paralelamente a estas estimaciones dosimétricas, el Servicio de Prevención de Riesgos Laborales realizó la vigilancia de la salud, concluyendo que la trabajadora no tenía ningún indicio de haber recibido dosis de la magnitud registrada por su dosímetro.In a room of electrophysiology from the cardiology service where procedures are made guided with X-Rays of ablation with radiofrequency and from implants ventricular defibrillation; there were registered monthly doses usually high in the same personal dosimeter flap of a nursing assistant who works there with values of equivalent personal doses, Hp (10

  14. Comunicato stampa N°235 della IARC "LA IARC AFFERMA CHE ANCHE L'ESPOSIZIONE A BASSE DOSI DI RADIAZIONI AUMENTA IL RISCHIO DI MORIRE DI LEUCEMIA TRA I LAVORATORI DEL SETTORE NUCLEARE" pubblicato il 22 Giugno 2015

    OpenAIRE

    Fellone, Lucio

    2015-01-01

    Versione autorizzata in italiano del Comunicato Stampa della IARC N°235 pubblicato il 22 giugno 2015: "LA IARC AFFERMA CHE ANCHE L'ESPOSIZIONE A BASSE DOSI DI RADIAZIONI AUMENTA IL RISCHIO DI MORIRE DI LEUCEMIA TRA I LAVORATORI DEL SETTORE NUCLEARE". Documento originale all'indirizzo: http://www.iarc.fr/en/media-centre/pr/2015/pdfs/pr235_E.pdf Authorized Italian version of the IARC Press Release N°235 published on 22 June 2015: EVEN LOW DOSES OF RADIATION INCREASE RI...

  15. Análisis dosimétrico de la técnica de braquiterapia oftálmica de baja tasa de dosis (LDR) con placas epiesclerales de 125I

    OpenAIRE

    Mariño Barreto, John Manuel

    2012-01-01

    La braquiterapia epiescleral constituye junto a la enucleación y otras modalidades terapéuticas, una de las técnicas más utilizadas en el tratamiento curativo del retinoblastoma y melanoma uveal en estadíos tempranos. La dosimetría de radiaciones juega un papel fundamental, puesto que permite conocer la distribución de dosis tanto en el tumor como en las estructuras críticas intraoculares, siendo en estas localizaciones específicas bastante relevante debido a la relativa cercanía existente en...

  16. Efecto de la dosis de glifosato sobre la biomasa de malezas de barbecho al estado vegetativo y reproductivo Glyphosate dose effect on weed biomass at the vegetative and reproductive stage

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    E. Puricelli

    2009-06-01

    Full Text Available Los experimentos se condujeron en el campo experimental de la Facultad de Ciencias Agrarias ubicado en Zavalla (Argentina durante 2005 y 2006. El objetivo de este trabajo fue estudiar la eficacia de glifosato aplicado al estado vegetativo y reproductivo de Convolvulus arvensis, Oenothera indecora, Iresine diffusa, Parietaria debilis, Rumex paraguayensis y Trifolium repens. El diseño del experimento fue completamente al azar con un arreglo factorial: año, especies, estado reproductivo y vegetativo y dosis de glifosato 48% (4X, 2X, 1X, 1/2X, 1/4X, 0X siendo X la dosis recomendada 1200 g i.a. ha-1. Se estableció la relación entre la dosis de glifosato y el control de la biomasa de las malezas a través de curvas de dosis respuesta con un modelo log-logístico. Se comparó el grado de tolerancia por medio de la DL50. En ambos estados de las malezas, la mayor DL50 obtenida para I. diffusa indica que de las especies estudiadas ésta es la más tolerante a glifosato. El número de especies tolerantes al glifosato es menor al estado vegetativo que al reproductivo.Experiments were conducted at the University of Rosario Experimental Farm, Zavalla in 2005 and 2006 to study the effect of glyphosate on the control of Convolvulus arvensis, Oenothera indecora, Iresine diffusa, Parietaria debilis, Rumex paraguayensis and Trifolium repens at the vegetative and reproductive stage. The experiments were established in a complete randomized design with the following factorial arrangement of treatments: year, species, vegetative and reproductive growth stages and glyphosate 48% (4X, 2X, 1X, 1/2X, 1/4X, 0X being 1X the recommended dose (1,200 g a.i. ha-1. The relationship between glyphosate dose and weed biomass control was established with a log-logistic model. The degree of tolerance was compared by LD50. In both stages, the higher LD50 was obtained for I. diffusa indicating that this is the species most tolerant to glyphosate among those studied. The number of

  17. Toxicidad oral a 60 días del aceite de sacha inchi (Plukenetia volubilis L.) y linaza (Linum usitatissimum L.) y determinación de la dosis letal 50 en roedores Oral toxicity at 60-days of sacha inchi oil (Plukenetia volubilis L.) and linseed (Linum usitatissimum L.), and determination of lethal dose 50 in rodents

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    Arilmi Gorriti; Jorge Arroyo; Fredy Quispe; Braulio Cisneros; Martín Condorhuamán; Yuan Almora; Víctor Chumpitaz

    2010-01-01

    Objetivos. Evaluar la toxicidad oral a 60 días y determinar la dosis letal 50 (DL 50) de los aceites crudos de sacha inchi (Plukenetia volubilis L.) y linaza (Linum ussitatisimum) en ratas Holtzman y en ratones cepa Balb C57, respectivamente. Materiales y métodos. Para la evaluación de la toxicidad oral a dosis repetida por 60 días se utilizó 24 ratas macho Holtzman divididos en tres grupos de ocho cada uno, los grupos fueron: solución salina fisiológica 4 mL/kg (SSF), aceite de sacha inchi 0...

  18. Respuesta productiva de un cultivo de maíz ("Zea mays" L. Var. Dracma) a distintas dosis de nitrógeno con dos tipos de riego (aspersión e inundación) y efecto sobre la lixiviación de nitratos

    OpenAIRE

    Oyarzun Arrechea, Montserrat

    2010-01-01

    La agricultura se sitúa hoy en la necesidad de ajustar las dosis y forma de aplicación de fertilizantes nitrogenados. De esta manera serán aprovechados de manera óptima y generarán la menor cantidad de efectos indeseables. Conseguirlo reportará beneficios económicos así como ambientales; a su vez se mantendrá e incluso aumentará la producción del cultivo del maíz. Los objetivos de este trabajo fin de carrera son los siguientes: •Determinación de la dosis óptima de fertiliza...

  19. Efectividad y seguridad de la viscosuplementación con dosis única de ácido hialurónico estabilizado de origen no animal (NASHA) para el tratamiento del dolor secundario a gonartrosis Efficacy and safety of single intra-articular injection of non-animal stabilized hyaluronic acid (NASHA) for gonarthrosis pain treatment

    OpenAIRE

    M.M. Monerris Tabasco; I. Martí Acebedo; G. Roca Amatria; R. M. Rincón Párraga; M. Hinojosa Zaguirre; Y. Jiménez Capel; D. Samper Bernal

    2012-01-01

    Objetivos: valorar la efectividad y seguridad de la inyección de dosis única de ácido hialurónico estabilizado de origen no animal (NASHA) para el tratamiento del dolor secundario a gonartrosis. Material y métodos: se han incluido un total de 37 pacientes afectos de gonartrosis diagnosticada previamente por el Traumatólogo/Reumatólogo en los que ha fracasado el tratamiento conservador y/o que no son tributarios de tratamiento quirúrgico. Se les ha efectuado una infiltración en dosis única de ...

  20. Intoxicación por organofosforados con necesidad de altas dosis de atropina y administración tardía de oximas

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    Mario Andrés Leotau Rodríguez, MD

    2010-01-01

    Full Text Available La intoxicación por organofosforados es una de las causas más frecuentes de intoxicación en el mundo y una de las tres normas principales de suicidio, llegando a mortalidades cercanas al 15 %. Esta radica en la inhibición irreversible que sus componentes hacen en la enzima acetilcolinesterasa, llevando con ello a la aparición de signos y síntomas secundarios al exceso de acetilcolina en los sistemas donde actúa. Su manejo aún es controvertido y sigue basándoseen las medidas de descontaminación, utilización de atropina, oximas y benzodiacepinas, sin haber consenso en muchas de las dosis e intervalos de tiempo para la administración de estos medicamentos. En este artículo exponemos un caso en el cual se hace necesario utilizardosis e intervalos de administración de atropina y el uso tardío de las oximas. Con este caso se puede concluir que la administración tardía de oximas y la utilización de grandes cantidades de atropina pueden ser una alternativa en el manejo de este tipo de intoxicación.______________________________________________________________________Organophosphate poisoning is one of the most frequent causes of poisoning in the world and one of the three main forms of suicide, reaching roughly 15% mortality, this lies in the irreversible inhibition that make components in the enzyme acetylcholinesterase, leading thus the signs and symptoms secondary to excessive acetylcholine in the systems where it operates. Its management is still controversial and remains based on the decontaminationmeasures, use of atropine, oximes and benzodiazepines, no consensus on many of the doses and time intervals for administration of these drugs. In this article we present a case in which it becomes necessary to use dose and timing of administration of atropine and late use of oximes. In this case we can conclude that the late administration of oximes using grades and quantities of atropine may be an alternative in handling this type of

  1. Treatment of pneumonia in infants with daily single oral dose of cefixime Tratamiento de la neumonía del lactante con cefixima en dosis única diaria

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    Rafael J. Manotas Cabarcas

    1997-01-01

    Full Text Available Treatment of pneumonia in infants with dail y single oral dose of cefixime Twenty five male and female Infants aged two to twenty-three months suffering from bacterial pneumonia were treated with cefixime in order to evaluate clinical efficiency and tolerance. A daily single oral dose of 8 mg kg was given for fourteen days. Clinical status and radiologic and laboratory findings improved during the course of therapy. A case of gastrointestinal intolerance (4% and twelve (48% of high levels of transaminases were observed. In 6 cases (24% the ethiologic agent was found. No significant differences were detected in clinical or paraclinical behavior between the groups of known and unknown ethiology. Therapy was quite successful in 96% of the C8ses. Hepatic effects of cefixime ought to be further Investigated. Para evaluar la eficacia clínica y la tolerancia a la Cefixima, se trató con ella un grupo de 25 niños y niñas lactantes de 2 a 23 meses de edad, que padecían neumonías bacterianas. Se usó una dosis de 8 mg/kg/día, por vía oral, durante catorce días y en una sola toma. Los signos clínicos evaluados, los hallazgos radiológicos y los de laboratorio mejoraron en el transcurso de la terapia. Se presentaron un caso (4% de intolerancia gastrointestinal y doce (48% con aumento de las transaminasas. En el 24% se encontró el agente causal. No se detectó una diferencia significativa en el comportamiento clínico y paraclínico de los niños con neumonía de etiología conocida en comparación con aquéllos en que no se la definió. Se obtuvo un 96% de resultados muy buenos en la terapia. Se debe investigar más el efecto del medicamento sobre la función hepática.

  2. Evaluación de la nitazoxanida en dosis única y por tres días en parasitosis intestinal Nitazoxanide vs albendazole against intestinal parasites in a single dose and for three days

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    Uri Belkind-Valdovinos

    2004-08-01

    Full Text Available OBJETIVO: Evaluar la utilidad de nitazoxanida en dosis habitual con esquema de tres días y en dosis única, para la erradicación masiva de parásitos intestinales en la población pediátrica, comparando su efecto con el del albendazol en dosis única. MATERIAL Y MÉTODOS: Se realizó un ensayo clínico aleatorizado, en tres comunidades rurales de la región central de México, durante el periodo 2001-2003, para incluir tres posibles alternativas de tratamiento en 786 sujetos de entre 5 y 11 años de edad, de los cuales 92 tuvieron un examen parasitológico positivo (15.1%. El grupo 1 incluyó 27 pacientes que recibieron 400 mg de albendazol en dosis única; el grupo 2 incluyó 34 pacientes a quienes se administró nitazoxanida en dosis de 15 mg/kg/día durante tres días consecutivos; y el grupo 3 incluyó 31 pacientes que recibieron 1.2 g de nitazoxanida en dosis única. Se evaluó diferencia de proporciones mediante prueba exacta de Fisher. RESULTADOS: No existieron diferencias estadísticamente significativas en la efectividad de los tres esquemas de tratamiento: (80.5% con albendazol, comparado con las dos alternativas adicionales de nitazoxanida (67.6% y 71%, respectivamente. Se observó una mayor prevalencia de efectos secundarios con nitazoxanida por kg /día (26.5% y en dosis única (32.2%, en comparación con la dosis única de albendazol (7.4%. CONCLUSIONES: Las evidencias en cuanto a la efectividad y elevada prevalencia de efectos secundarios de la nitazoxanida no justifican aún su utilización como quimiopreventivo masivo para el control de parasitosis intestinal en áreas endémicas. En países con elevada prevalencia de parasitosis intestinal las medidas de prevención primaria que continúan vigentes, y que deben priorizarse, están relacionadas con sanidad pública, introducción de agua potable y drenaje, cloración de agua y manejo adecuado de excretas de animales domésticos, así como educación para la salud.OBJETIVE: To

  3. Sistema hipermedia para administrar objetos de aprendizaje en educación secundaria

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    Lino Tetlalmatzi Montiel

    2015-02-01

    Full Text Available En la actualidad, las instituciones educativas se han visto en la necesidad de implementar programas de enseñanza apoyados en los avances tecnológicos para la mejora continua de sus alumnos. En el presente artículo se propone un sistema hipermedia administrador de objetos de aprendizaje, cuya aplicación tiene como objetivo mejorar el proceso enseñanza aprendizaje y desarrollar el hábito del auto aprendizaje, además de estar dirigido al nivel de educación secundaria. En la primera etapa se define una estructura para el contenido del objeto de aprendizaje (OA, en la segunda fase se especifica una estructura del dominio del conocimiento y una estructura de almacenamiento a un repositorio de OA. Al crear este repositorio, los OA estarán disponibles para reutilizarse en la estructuración de otras asignaturas relacionadas con su contenido, para lo cual este debe cumplir con el estándar Dublín Core en la especificación de los metadatos durante la integración al repositorio.

  4. Utilización del citrato de fentanilo oral transmucosa como rescate terapéutico en pacientes con altas dosis de opioides Use of oral transmucosal fentanyl citrate for therapeutic rescue in patients receiving high doses of opiates

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    J. Cevas

    2005-07-01

    Full Text Available El control del dolor irruptivo (DI en pacientes oncológicos que tienen controlado su dolor basal con altas dosis de opioides se presenta como complejo. No existen referencias en la literatura que orienten sobre el fármaco, dosis y vía de administración adecuada para su tratamiento, por lo que este se fundamenta en conductas no estandarizadas, basadas en la práctica clínica. Con el presente estudio queremos dar a conocer nuestra experiencia en el tratamiento de este tipo de dolor en este tipo de pacientes. Objetivos: Evaluar la efectividad y seguridad de CFOT en el tratamiento de las crisis de DI en pacientes oncológicos que tienen controlado su dolor de base con dosis elevadas, comparándolo con los tratamientos que recibían previamente. Se evaluó, así mismo, el grado de satisfacción del paciente respecto a la medicación evaluada. Material y métodos: Sobre un total de 280 pacientes oncológicos visitados en nuestro servicio durante el año 2003, 25 reunían los criterios requeridos. A todos ellos se les instó a tratar sus crisis de DI con CFOT, con dosis iniciales de 400 mcg, que podían incrementar, en función de respuesta y efectos adversos. Para ello, se evaluó respuesta clínica según valoración Escala Analógica Visual, y se recogieron todos los efectos adversos relacionados con la medicación y reportados por los pacientes. Por último, se valoró el grado de satisfacción del paciente mediante el cuestionario propuesto por Kornick. Resultados: Las dosis media efectiva con la que se controlaba las crisis de DI fue de 600 mcg, la titulación se consiguió en la mayoría de los casos a los 2 días, los efectos adversos fueron los típicamente observados con el tratamiento opioide. La mayoría de pacientes prefirieron CFOT a sus tratamientos previos. Los pacientes consideraron las pautas de tratamiento como sencillas de cumplir. Conclusiones: CFOT puede considerarse como una opción segura y efectiva en el tratamiento de las

  5. Efficacy of herbicide dose and plant growth stage on weeds present in fallow ground Eficacia de herbicidas según la dosis y el estado de crecimiento de malezas presentes en un suelo en barbecho

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    D. Faccini

    2007-06-01

    Full Text Available There is little information about the precise dose of different herbicides for weeds in fallows. Herbicide efficacy varies for each weed species and plant size. The effect of glyphosate, 2,4-D, and metsulfuron-methyl + dicamba doses on biomass control of annual and perennial weed species at the vegetative and reproductive stage present in the autumn-winter-spring fallow in the soybean central region of Argentina was studied. Experiments were conducted in pots in 2003 and 2004. At the vegetative and reproductive stages, glyphosate, 2,4-D, metsulfuron-methyl + dicamba in three doses (2X, 1X, 1/2X were applied; 1X being the recommended dose: 1440 g a.i./ha for glyphosate, 800 g a.i./ha for 2,4-D and 5.4 + 48 g a.i./ha for metsulfuron-methyl + dicamba. A control or check without application was included in the experiment. Thirty days after application, plant biomass was determined for each treatment in relation to the check. For all herbicides many species were adequately controlled with 2X but control was unsatisfactory for most species with 1⁄2X. Control at the vegetative stage was higher or similar to control at the reproductive stage. Perennial species were difficult to control with all herbicides.Existe escasa información sobre la dosis precisa de herbicidas para el control de malezas en barbechos. La eficacia herbicida varía según la especie y el tamaño de las malezas. Se estudió el efecto de distintas dosis de glifosato, 2,4-D y metsulfuron- metil + dicamba sobre el control de la biomasa de malezas anuales y perennes en estado vegetativo y reproductivo, presentes en barbechos otoñoinverno- primaverales en la región sojera central de Argentina. Los experimentos se realizaron en macetas, con las plantas en estado vegetativo y reproductivo, durante los años 2003 y 2004. Se utilizaron los herbicidas glifosato, 2,4-D y metsulfuron- metil + dicamba en tres dosis (2X, 1X, ?X; 1X es la dosis recomendada (1440 g i.a./ha para glifosato, 800 g

  6. Doble dosis de estreptocinasa en tromboembolismo pulmonar masivo con trombo flotante libre en la aurícula derecha Double conventional doses of streptokinase in a massive pulmonary thromboembolism with a free-floating thrombus in the right atrium

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    Eduardo A. Sampó

    2004-06-01

    Full Text Available Presentamos el caso de una paciente con tromboembolismo pulmonar grave, disfunción ventricular derecha y shock sostenido, con altos requerimientos de drogas vasoactivas, con un trombo flotante en aurícula derecha, cuya situación hemodinámica y clínica, así como la imagen ecocardiográfica fueron resueltas mediante la infusión endovenosa de dos dosis completas de estreptocinasa, separadas por un intervalo de 72 horas.We present a case of severe thromboembolism, with right ventricular dysfunction, high vasoactive drug requirements, sustained shock and a free-floating thrombus in right atrium. Hemodynamic and clinical picture as well as the echocardiographic image were solved after intravenous infusions of two complete doses of streptokinase, separated by an interval of 72 hours.

  7. Identificación de portadoras de distrofia muscular de Duchenne y Becker (DMD/DMB mediante análisis de dosis génica y polimorfismos de DNA

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    Restrepo C. M.

    2001-06-01

    Full Text Available La DMD/DMB es la distrofia muscular más común en el hombre, se hereda de manera Ligada al Sexo Recesiva y se debe, en muchos casos, a deleciones de uno o más exones del gen de la Distrofina; esta ocurre por mutaciones "de novo" (40%, aunque en los casos familiares, la madre y algunas mujeres por línea materna serán portadoras con un riesgo de 50% de hijos afectados, identificación que es difícil en ausencia de estudios de DNA. El presente estudio identifica mujeres portadoras mediante el análisis de dosis génica y/o polimorfismos intragénicos de DNA (1-7.

  8. Efecto sobre el maíz de la aplicación de dos técnicas de riego y tres dosis de nitrógeno en Sinaloa, México: valoración ambiental

    OpenAIRE

    Tomás Díaz Valdés; Wilfredo Pérez Duarte; Leopoldo Partida Ruvalcaba; Teresa de Jesús Velásquez Alcaraz; Ramón Lizárraga Jiménez

    2009-01-01

    El Estado de Sinaloa, México, se encuentra enclavado en una región de clima semiárido, con una agricultura intensiva, donde el uso adecuado del agua y los fertilizantes nitrogenados son factores claves en la producción agrícola, la mitigación ambiental y la reducción de los costos de producción. En base a lo anterior, el objetivo de esta investigación fue evaluar el efecto en la planta de maíz y valoración económica por la acción de dos técnicas de riego y tres dosis de nitrógeno, cultivada e...

  9. Desarrollo de un modelo de cálculo de dosis en tratamientos de cáncer de próstata con IMRT utilizando la herramienta GEANT4 de simulación Monte Carlo

    OpenAIRE

    Ayala Álvarez, David Santiago

    2012-01-01

    En este trabajo se presenta la implementación de un modelo de cálculo de dosis con base en la herramienta Geant4 de simulación Monte Carlo. Se realizaron pruebas de validación del método utilizando un simulador físico homogéneo de agua irradiado con haces de fotones de 6MeV generados en un acelerador lineal de electrones de uso clínico. El código final utiliza como entrada un conjunto de imágenes dicom de un paciente real generadas a partir de una voxelización de imágenes de CT adquiridas en ...

  10. Evaluación de la toxicidad aguda por el procedimiento de dosis fijas de un extracto de Boldoa purpurascens Cav. (Evaluation of the acute toxicity of the method fixed dose procedure of an extract of Boldoa prurpurascens Cav.

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    Pérez Machín, Maykel

    2008-03-01

    Full Text Available ResumenSe realizó un estudio experimental con el objetivo de evaluar el posible efecto tóxico de un extracto acuoso liofilizado de Boldoa purpurascen Cav. (nitro blanco. Para el desarrollo del mismo se utilizó el Procedimiento de Dosis Fijas (FDP, utilizando una dosis límite de 2000 mg/kg de peso corporal. Los animales seleccionados fueron ratas de la línea Sprague Dawley, con un peso comprendido entre 150 y 200 g. Los resultados demostraron la inocuidad de la planta al no observarse signos ni síntomas de toxicidad. El peso corporal se comportó acorde a la curva de crecimiento de la especie y no se apreciaron alteraciones macroscópicas en los órganos estudiados, todo lo que permite afirmar que la DL50 se ubica por encima de 2000 mg/kg PC, considerándose el producto como No Clasificado (no tóxico. SummaryAn experimental study to assess the toxic effects of an aqueous and later lyophilised extract of Boldoa purpurascens Cav. (nitro blanco was carried out. It was employed the alternative Fixed Dose Procedure. There were used Sprague Dawley rats weighing between 150 and 200 g, which received a limit dose of 2000 mg/kg body weight and were kept under standardized experimental conditions. Results showed neither signs nor symptoms of toxicity. Bodyweight behaved consistent with the growing curve of this species and there were no alterations in macroscopic observations on main organs. The LD50 of this extract is located above 2000 mg/kg body weight, considering it as Non Classified (non toxic.

  11. Cuantificación de radón (222Rn en aire y dosis de radiación en baños termales del norte de México

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    María de Lourdes Villalba

    2015-01-01

    Full Text Available La radiación en aguas termales utilizadas como zonas recreativas puede representar un problema de salud pública. El objetivo fue cuantificar el nivel de radón (222Rn en aire y evaluar la dosis de radiación en los baños termales establecidos en San Diego de Alcalá, Chihuahua, México. Se seleccionó un espacio de esparcimiento, se cerró puerta y ventana para simular la utilización del baño termal por el público. El nivel de 222Rn en aire se detectó utilizando un instrumento AlphaGUARD (Professional Radon Monitor de la marca GENITRON. Éste se cuantificó en Bq m-3 en diferentes tiempos 10, 20, 30, 40, 50 y 60 min, se realizaron tres mediciones; la primera en la epoca de invierno 2014 (enero y dos en la epoca de primavera de 2015 (mayo y junio. El análisis estadístico fue mediante una regresión para cada medición. Se estimó la Dosis Promedio Anual (DPA efectiva de inhalación de radón a la que se encuentran expuestas las personas que acuden a los baños termales dependiendo del número de visitas y tiempo de permanencia, el rango varió de 0.0005±4x10-4 mSv cuando se visitan los baños 12 veces al año con un permanencia de 10 minutos, hasta 0.0352±1.1x10-2 mSv visitando una vez a la semana por un periodo de 60 minutos. |

  12. Development of artificial viruses for nanomedicine and gene therapy

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    Saccardo, Paolo

    2015-01-01

    La convergencia de diversas disciplinas como la biotecnología, biología molecular e ingeniería genética en el desarrollo de vehículos terapéuticos a escala nanometrica para la entrega de moléculas terapeuticas, se plantea como una herramienta con un elevado potencial en el campo de la nanomedicina. El mayor reto de estos nanovehiculos es permitir una eficaz entrega de ácidos nucleicos, proteínas o incluso fármacos, con una elevada especificidad celular para poder así disminuir la dosis admin...

  13. Usefulness of recombinant human TSH-aided radioiodine doses administered in patients with differentiated thyroid carcinoma Administración de dosis terapéuticas de radioyodo luego de TSH recombinante en pacientes con carcinoma diferenciado de tiroides

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    Fabián Pitoia

    2006-04-01

    de enfermedad metastática. Para evaluar la efectividad de la administración de dosis terapéuticas de RI luego de la administración de rhTSH, realizamos un análisis retrospectivo en 28 pacientes con CDT que recibieron 39 dosis de RI. Los pacientes se dividieron en 2 grupos: GI (n=17 pacientes con captación en el lecho tiroideo y niveles indetectables de tiroglobulina (Tg bajo tratamiento supresivo con levotiroxina y GII (n=11, pacientes con enfermedad metastática local o a distancia, previamente comprobada. El seguimiento promedio luego de la primera dosis de RI fue de 32 ± 13 meses (rango 8 a 54 meses. Dieciseis pacientes (94% del GI fueron considerados libres de enfermedad y un paciente presentó una persistencia local. En el GII, las captaciones patológicas fueron: en 4 pacientes en pulmones; en 4 en mediastino y en 3 a nivel lateral cervical. Dos pacientes con captaciones mediastinales presentaron niveles indetectables de Tg. En el seguimiento, dos pacientes con captaciones latero-cervicales se consideraron libres de enfermedad, cuatro pacientes murieron (tres debido al CDT avanzado y cinco de los restantes tienen enfermedad persistente. En conclusión, la terapia con RI luego de rhTSH fue útil para ablacionar remanentes normales en el GI. Los niveles de Tg estimulados con rhTSH fueron indetectables en dos pacientes con metástasis mediastinales. El uso de rhTSH parece ser una alternativa válida frente a la suspensión de la terapia hormonal en el tratamiento de pacientes con CDT, incrementando la calidad de vida de estos pacientes.

  14. Relación de métodos de labranza, siembra, riego y dosis de nitrógeno con el rendimiento de trigo Relationship of tillage and planting methods, irrigation, and nitrogen rate with wheat yield

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    Lourdes Ledesma Ramírez

    Full Text Available El objetivo fue determinar los efectos de cuatro métodos de labranza, dos métodos de siembra, tres dosis de nitrógeno y dos calendarios de riegos sobre el rendimiento de cuatro variedades de trigo. La investigación se estableció en los ciclos otoño-invierno 2004-2005, 2005-2006 y 2006-2007. Se evaluaron cuatro métodos de labranza: barbecho-rastra, cero-labranza, multiarado-rastra y rastra; dos métodos de siembra: melgas y surcos; dos calendarios de riego; cuatro y tres riegos; tres dosis de fertilización nitrogenada: 120, 160 y 240 kg ha-1; y cuatro genotipos: línea V-56, Bárcenas S2002 de tipo harinero, Gema C2004 y Topacio C97 de tipo cristalino. Los análisis de varianza en los cuatro métodos de labranza no detectaron diferencias en rendimiento en los factores principales años y métodos de siembra. El método de labranza barbecho-rastra y los métodos de siembra interaccionó con la dosis de nitrógeno. El número de riegos afectó el rendimiento de grano en tres métodos de labranza: barbecho-rastra, multiarado-rastra y rastra; del mismo modo, el calendario de cuatro riegos produjo mayor rendimiento que el de tres riegos. El rendimiento promedio de las variedades de trigo harinero Bárcenas S2002 y V-56 superó a las variedades cristalinas bajo el método de cero-labranza, pero no en los otros métodos. En el método de barbecho-rastra, la variedad Gema C2004 mostró mayor rendimiento; en cero-labranza fueron las variedades Bárcenas S2002 y V-56; y para rastra fueron las variedades Gema C2004 y Bárcenas S2002. Una mayor disponibilidad de humedad incrementó la eficiencia en el uso del nitrógeno y el rendimiento.The objective of this study was to determine on the yield of four wheat varieties the effects of four tillage and two planting methods, three nitrogen rates and two irrigation schedules. The research was carried out during the winter cycles of 2004-2005, 2005-2006 and 2006-2007. We assessed four tillage methods

  15. Estatinas para el Síndrome Coronario Agudo Medicina basada en evidencia sobre la administración temprana con dosis de carga Statins in Acute Coronary Syndrome Use of an Early Loading Dose

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    Carlos Fonseca-Gamboa

    2011-09-01

    Full Text Available Objetivo: En algunos Servicios de Emergencias de la CCSS, a los pacientes con infarto agudo de miocardio se les administra una dosis alta -aunque variable- de lovastatina en las primeras horas de evolución de los síndromes coronarios agudos, con la expectativa de lograr efectos pleiotrópicos, un resultado positivo sobre el endotelio y la disminución de mediadores inflamatorios. Analizar la evidencia científica que sustenta el beneficio de esta intervención farmacológica y clarificar la posible dosis oral y el potencial intervalo idóneo. Búsqueda vía electrónica en sistemas secundarios de información científica y análisis de fuentes primarias, con énfasis en ensayos clínicos aleatorizados que evalúen la eficacia de las estatinas en los eventos coronarios agudos; también de fuentes terciarias, específicamente revisiones sistemáticas y guías de consenso para práctica clínica basadas en evidencia y revisiones por instancias evaluadoras de tecnologías con reconocimiento internacional. Resultados: Cuatro ensayos clínicos aleatorizados controlados con placebo, no demostraron diferencias significativas ni clínicamente relevantes en la variable primaria combinada: evento cardiaco mayor, muerte, IAM recurrente fatal, AVC fatal u otra causa de muerte cardiovascular, ninguno usó dosis de carga, ni se inició la administración en las 24 hs del inicio de la sintomatología. Conclusión: Ante la falta de evidencia que permita proyectar con claridad un papel beneficioso para las estatinas en el manejo inicial del síndrome coronario agudo, esta práctica desequilibra la relación beneficio/riesgo y se aleja de los principios del uso racional de medicamentos y la aplicación del paradigma de la medicina basada en evidencia.Aim: It has been observed that in some emergency services it has become a common practice to prescribe a high but variable loading dose of statins to patients with acute myocardial infarction within the first few

  16. Aplicación de vibraciones sobre la superficie del dializador: Efecto en la dosis de heparina Application of vibrations to the dialyser surface: Effect on the heparin dose

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    Alberto Sánchez Martín

    2010-09-01

    Full Text Available El cebado del dializador realizado de manera adecuada, hace que se expandan los capilares correctamente y se impregne bien la membrana con la solución. Con el objetivo de facilitar el cebado del dializador se colocó junto al dializador un dispositivo que, de forma constante, realiza un movimiento de vibración en su interior lo que favorece la correcta eliminación de microburbujas y el reparto homogéneo de la heparina. Se incluyeron en este estudio a 8 pacientes que tenían requerimientos de heparina mayores de los habituales y que sus dializadores al finalizar la sesión presentaban capilares coagulados. Durante trece sesiones se aplicó el dispositivo reduciendo la dosis de heparina a la tercera sesión si el dializador se mantenía limpio al finalizar ésta. Se realizó un registro fotográfico del estado del dializador al finalizar la sesión. La dosis media de heparina inicial fue de 3500 ± 534,522 u.i. y al finalizar el estudio fue de 2562,50±728,869 u.i., los índices de hemólisis, Kt/V, hemoglobina y resto de parámetros analíticos no evidencian diferencias. El registro fotográfico mostró dializadores limpios al finalizar el estudio. Con este método hemos conseguido que el circuito se mantenga limpio con dosis de heparina inferiores y sin alteración de los parámetros analíticos.When the dialyser is suitably primed, the capillaries expand correctly and the membrane is well impregnated with the solution. In order to facilitate the priming of the dialyser, a device was placed next to the dialyser which constantly produces a vibration inside it to favour the correct elimination of microbubbles and uniform distribution of the heparin. This study included 8 patients with higher than normal heparin requirements and whose dialysers at the end of the session showed coagulated capillaries. Over thirteen sessions, the device was applied reducing the heparin dose on the third session if the dialyser was still clean at the end of that

  17. Anestesia endovenosa en perros mediante el uso de propofol en dosis única, premedicado con acepromazina-atropina y xilazina-atropina Intravenous anaesthesia in dogs using a single dose of propofol premedicated with atropine _ acepromazine or atropine _ xylazine

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    J. THIBAUT

    2002-01-01

    Full Text Available Se efectuó la valoración de la acción anestésica del propofol en perros, mediante administración endovenosa en dosis única, con dos protocolos de premedicación: atropina - acepromacina, y atropina - xilacina. Se trabajó con 20 perros mestizos de uno a seis años de edad, clínicamente sanos, divididos al azar en dos grupos de 10 cada uno. Al primer grupo, de 16.2±1.63 kg, se administró acepromacina en dosis de 1.5 mg/kg i.m. , al grupo 2, de 11.9±1.71 kg, se le aplicó xilacina en dosis de 3 mg/kg i.m. A ambos grupos se inyectó atropina en dosis de 0.1 mg/kg s.c. Se administraron 10 min. más tarde 5 mg/kg de propofol en la vena femoral, luego se evaluó el efecto del propofol sobre las variables: período de latencia, duración de la anestesia quirúrgica , período de recuperación anestésica, frecuencia respiratoria, frecuencia cardíaca, presión arterial y temperatura corporal. Además se determinaron las reacciones adversas. Los resultados difirieron significativamente entre los dos grupos. La inducción anestésica fue de 0.45 + 0.03 min. en el primero (A.A.P y 0.26 + 0.03 min. en el segundo (X.A.P. La duración de la anestesia quirúrgica fue de 12.3 + 1.89 min y 25.2 + 1.78 min y el período de recuperación de 4.5 + 0.63 min y 10,1 + 0,98 min en el grupo 1 y 2, respectivamente. Las variables fisiológicas en ambos grupos se mantuvieron sin modificaciones estadísticamente significativas durante el transcurso de la anestesia quirúrgica; la frecuencia respiratoria tuvo un valor inicial promedio de 14.3 + 2.45 y 13.0 + 1.54 ciclos/min. en el grupo 1 y 2, respectivamente. La frecuencia cardíaca fue de 175 + 11.81 lat/min en el grupo 1 y 148.4 + 9.04 lat/min en el grupo 2. La presión arterial promedio fue de 102.6 + 5.69 y 111.8 + 10.43 mm Hg para el grupo 1 y 2 respectivamente y la temperatura corporal en el grupo 1 fue de 38.5 + 0.17 y en el grupo 2 de 38.7 + 0.20 ºC. Las reacciones adversas se presentaron al inicio de la

  18. A simple method for estimating the effective dose in dental CT. Conversion factors and calculation for a clinical low-dose protocol; Eine einfache Methode zur Abschaetzung der effektiven Dosis bei Dental-CT. Konversionsfaktoren und exemplarische Berechnung fuer ein klinisches Low-Dose-Protokoll

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    Homolka, P.; Kudler, H.; Nowotny, R. [Inst. fuer Biomedizinische Technik und Physik, Univ. Wien (Austria); Gahleitner, A. [Wien Univ. (Austria). Abt. fuer Osteologie; Wien Univ. (Austria). Zahn-, Mund- und Kieferheilkunde

    2001-06-01

    An easily appliable method to estimate effective dose including in its definition the high radio-sensitivity of the salivary glands from dental computed tomography is presented. Effective doses were calculated for a markedly dose reduced dental CT protocol as well as for standard settings. Data are compared with effective doses from the literature obtained with other modalities frequently used in dental care. Methods: Conversion factors based on the weighted Computed Tomography Dose Index were derived from published data to calculate effective dose values for various CT exposure settings. Results: Conversion factors determined can be used for clinically used kVp settings and prefiltrations. With reduced tube current an effective dose for a CT examination of the maxilla of 22 {mu}Sv can be achieved, which compares to values typically obtained with panoramic radiography (26 {mu}Sv). A CT scan of the mandible, respectively, gives 123 {mu}Sv comparable to a full mouth survey with intraoral films (150 {mu}Sv). Conclusion: For standard CT scan protocols of the mandible, effective doses exceed 600 {mu}Sv. Hence, low dose protocols for dental CT should be considered whenever feasable, especially for paediatric patients. If hard tissue diagnoses is performed, the potential of dose reduction is significant despite the higher image noise levels as readability is still adequate. (orig.) [German] Eine Methode, die eine einfache Bestimmung der effektiven Dosis bei Dental-CT unter Beruecksichtigung der Strahlensensitivitaet der Gl. parotis und der Gl. submandibularis - sowohl bei Standard- als auch bei dosisreduzierten Protokollen - ermoeglicht, wird beschrieben. Weiters wird die effektive Dosis eines klinisch verwendeten Low-Dose-Protokolles abgeschaetzt und mit den haeufigsten dentalradiologischen Untersuchungsverfahren verglichen. Methoden: Aus publizierten effektiven Dosen fuer Maxilla und Mandibula Scans wurden Konversionsfaktoren ermittelt, mit deren Hilfe fuer abweichende

  19. La scrittura è terapeutica? Il metodo autobiografico e la composizione del sé

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    Nicola Ghezzani

    2010-02-01

    Full Text Available Far da sé il proprio ritratto biografico significa, in rapporto a queste alienazioni, sfidare i demoni della compiacenza e della connivenza con l’altro, quindi porre il rifiuto, l’opposizione e quindi il vuoto, il nulla, l’assenza come base sulla quale veder apparire le proprie scene e le proprie passioni. Solo se non devo rispondere di me stesso a nessun altro che a me stesso, io sono nella condizione di cogliermi nella mia delusione fondamentale, nell’opposizione frontale che ho verso il mondo o verso i valori recepiti, nella mia protesta di riscatto dalla soggezione, nelle mie istanze di vendetta, di cui avverto insieme la violenza apocalittica e la colpa morale, quindi posso valutare quanto sono trascinato da passioni, reso nemico agli altri e a me stesso, e quanto posso riequilibrare il mio essere sulla base di una valutazione intima, sentita, ponderata di ogni lato contrapposto della mia identità.

  20. Atividades terapeuticas: compreensao de familiares e profissionais de um centro de atencao psicossocial

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    Leandro Barbosa de Pinho

    2013-09-01

    Full Text Available OBJETIVO: analisar a compreensão de familiares e profissionais de saúde mental sobre as atividades terapêuticas no cotidiano de um Centro de Atenção Psicossocial. METODOLOGIA: Trata-se de uma pesquisa qualitativa realizada em um Centro de Atenção Psicossocial do Estado de Santa Catarina, Brasil. RESULTADOS: As atividades terapêuticas, por exemplo, revelam o leque de possibilidades de atuação e imersão das práticas nas novas tendências de cuidado na área, assim como o risco de adoção de posturas verticalizadas e cristalizadas, mais compatíveis com modelos de atendimentos tradicionais, contra as quais a própria Reforma Psiquiátrica luta há mais de 20 anos. CONSIDERAÇÕES FINAIS: Espera-se que o estudo proporcione novos olhares sobre a Reforma Psiquiátrica no contexto estudado, de modo a problematizar os processos de trabalhos das equipes e a relação dos serviços com os usuários que atendem.

  1. Adaptacao brasileira de questionario para avaliar adesao terapeutica em hipertensao arterial

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    Samara Ramalho Matta

    2013-06-01

    Full Text Available OBJETIVO: Descrever etapas da adaptação transcultural de questionário de avaliação de adesão terapêutica em hipertensão arterial, desenvolvido no idioma espanhol, para aplicação ao contexto brasileiro. MÉTODOS: A fim de estabelecer equivalências conceitual, de itens, semântica e operacional, foram realizadas duas traduções para o português de modo independente e duas retraduções para o espanhol. Traduções e retraduções foram avaliadas quanto à alteração nos significados referencial e geral. Realizaram-se duas aplicações de pré-testes com pacientes hipertensos e/ou diabéticos, com a versão síntese, que contribuíram para identificar diferentes problemas e confirmar decisões tomadas. RESULTADOS: A segunda tradução e retradução foram mais bem avaliadas, pois não houve alteração dos significados para cinco dos 12 itens do questionário. Foram feitas alterações operacionais, e uma vinheta com as opções de resposta e um exemplo no enunciado do instrumento facilitaram a aplicação nas entrevistas. CONCLUSÕES: Os resultados obtidos na avaliação das equivalências conceitual, de itens, semântica e operacional permitiram chegar a uma versão em português do questionário MBG para avaliar adesão terapêutica para aplicação no contexto brasileiro.

  2. Implementación de un protocolo de control de calidad para el paciente específico de radioterapia de intensidad modulada (IMRT) usando la película Kodak EDR-2 / Implementation of a patient specific intensity modulated radiation therapy quality assurance protocol using the Kodak EDR-2 film

    OpenAIRE

    Cáceres Maldonado, Luis Edinson

    2010-01-01

    Uno de los pasos más importantes en radioterapia de intensidad modulada antes de administrar el plan de tratamiento a un paciente especifico de IMRT, es quizá el de hacer la evaluación de la distribución de dosis para asegurar la precisión en los parámetros planeados y la exactitud en la dosis entregada; no obstante esta tarea no es fácil, porque hay que comparar una distribución de referencia con una distribución de prueba y esta tarea demanda considerable tiempo, los resultados son cualitat...

  3. Hidratación oral continua o a dosis fraccionadas en niños deshidratados por diarrea aguda Oral rehydration in continuous administration or in fractionated doses in dehydrated children with acute diarrhea

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    Felipe Mota-Hernández

    2002-01-01

    Full Text Available Objetivo. Evaluar la seguridad y efectividad de dos técnicas de hidratación oral. Material y métodos. Ensayo clínico aleatorio, hecho en el Servicio de Hidratación Oral del Hospital Infantil de México, Federico Gómez, entre septiembre de 1998 y junio de 1999. Cuarenta pacientes deshidratados por diarrea aguda, menores de cinco años, recibieron suero oral ad libitum (grupo AL y otros cuarenta lo recibieron en dosis fraccionada (grupo DF. Las características clínicas fueron similares en ambos grupos. Los resultados se presentan como promedio y desviación estándar o mediana, según la distribución de frecuencias simples y relativas. Resultados. El promedio de gasto fecal en el grupo AL fue 11.0±7.5 g/kg/h y en el grupo DF 7.1±7.4 (p=0.03. La ingesta de suero, el tiempo de hidratación y la diuresis promedio, fueron similares entre ambos grupos (p>0.05. Seis pacientes del grupo AL y cinco del DF tuvieron gasto fecal alto (>10 g/kg/hora, mejorando con la administración de atole de arroz. Un paciente del grupo AL y dos pacientes del DF tuvieron vómitos persistentes, mejorando con gastroclisis. Ningún paciente requirió rehidratación intravenosa. Conclusiones. Estos resultados sugieren que la administración de suero oral ad libitum, bajo supervisión, es tan segura y efectiva como la técnica de dosis fraccionada para el tratamiento de niños deshidratados por diarrea aguda.Objective. To evaluate the safety and effectiveness of two oral rehydration techniques. Material and Methods. A randomized clinical trial was conducted at the oral rehydration unit of Hospital Infantil de Mexico "Federico Gomez", between September 1998 and June 1999. Forty patients five-year old and younger children, dehydrated due to acute diarrhea, were given oral rehydration solution (ORS ad libitum (AL group; another forty patients received ORS in fractionated doses (FD group. Clinical characteristics were similar in both groups. Results are presented as

  4. Lixiviación de potasio y contenidos nutrimentales en suelo y alfalfa en respuesta a dosis de vinaza Potassium leaching and nutrient content in soil and alfalfa's response to a dose of vinasse

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    Patricia Flores Rodríguez

    Full Text Available Bajo condiciones de invernadero y con base a la concentración de potasio (K+ en la caracterización química de la vinaza, se evaluó el efecto de diferentes dosis (0, 250 y 500 kg ha-1 de K+ sobre el suelo, en columnas de cloruro de polivinilo (PVC, empleando lisímetros de succión a dos profundidades (23 y 46 cm y muestras al final de la columna (75 cm. En lixiviados se evaluó la concentración de K, el efecto sobre pH y conductividad eléctrica (CE, como cultivo indicador se uso alfalfa (Medicago sativa, efectuándose dos cortes, en un periodo de 120 días y una aplicación de vinaza al inicio del experimento y otra después del primer corte. En muestras de plantas las variables fueron materia seca, N T, B, Ca, Cu, Fe, K, Mg, Mn, Na, P, Zn y NO3 en suelo se consideró CE, pH, NH4, NO3, P, K, Na, Ca, Mg, Fe, Cu, Zn Mn y MO (materia orgánica. En el análisis estadístico la dosis 500 kg ha-1 de K tuvo efecto sobre la fertilidad del suelo, registrando un incremento en: MO, NH4, P, Ca, Na, Mg, Fe, Cu, Zn, Mn y K. La CE y K el mayor efecto (pUnder greenhouse conditions and based on the concentration of potassium (K+ in the chemical characterization of Vinasse, the effect of different doses (0. 250 y 500 kg ha-1 de K+ was evaluated in the soil, in columns of polyvinyl chloride (PVC, using suction lysimeters at two depths (23 and 46 cm and samples at the end of the column (75 cm. In Leaching, the K concentration, the effect on pH and the electric conductivity (CE was evaluated; as the crop indicator, alfalfa was used (Medicago sativa, making 2 cuts in a period of 120 days and applying vinasse at the beginning of the experiment and then again after the first cut. In plant samples, the variables were dry material, N T, B, Ca, Cu, Fe, K, Mg, Mn, Na, P, Zn and NO3 in soil, CE, pH, NH4, NO3, P, K, Na, Ca, Mg, Fe, Cu, Zn Mn abd MO (organic material was considered. In the statistical analysis of the K dose of 500 kg ha-1 there was an effect on the soil

  5. Influencia del momento y dosis de aplicación del nitrógeno sobre el rendimiento y la incidencia de Rhizoctonia Solani en el cultivo del arroz.

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    Ridelmis Rodríguez Hernández

    2007-12-01

    Full Text Available El trabajo fue realizado en el 2007, en el Centro Internacional de Tsukuba, perteneciente a la prefectura de Ibaraki, Japón con el objetivo de determinar la influencia que tienen el momento de aplicación fraccionada y la dosis de nitrógeno (N sobre el Rendimiento, además de la incidencia y severidad de la enfermedad Rhizoctonia solani en la variedad de arroz japónica Akitakomachi. La aplicación de fósforo y potasio se realizaron de base antes del trasplante y las de nitrógeno fueron en tres momentos: a la hora del trasplante, en el máximo macollamiento y en la iniciación de la panícula, según el tratamiento a estudiar. Se realizaron evaluaciones de desarrollo y crecimiento de la planta de arroz, así como el rendimiento y sus componentes. En los parámetros de crecimiento evaluados, los mayores valores fueron del tratamiento 4 (75-0-45 kg de N/ha, seguido por los tratamientos 2 (50-30-0, 3 (50-0-30 y 1 (0-0-0. El tratamiento con mayor incidencia y severidad de R. solani fue el 4 (75-0-45 con 5.80 y 0.18 %, respectivamente, siendo similares el 1(0-0-0 y 2(50-30-0, con menor porcentaje en ambos parámetros fue el tratamiento 3(50-0-30 con 3.7 y 0.13, respectivamente. En cuanto al rendimiento agricola, el mayor valor lo obtuvo el tratamiento 4 (75-0-45, seguido por el 2 (50-30-0, 3 (50-0-30 y 1 (0-0-0 con 7.88, 7.39, 6.73 y 2.63 t/ha, respectivamente.

  6. Efeitos neuromusculares e cardiovasculares do pipecurônio: estudo comparativo entre diferentes doses Efectos neuromusculares y cardiovasculares del pipecuronio: estudio comparativo entre diferentes dosis Neuromuscular and cardiovascular effects of pipecuronium: a comparative study between different dose

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    Angélica de Fátima de Assunção Braga

    2008-12-01

    del pancuronio, pero desprovisto de efectos cardiovasculares. Se evaluaron los efectos neuromusculares, condiciones de intubación traqueal y las repercusiones hemodinámicas de de los diferentes dosis de pipecuronio. MÉTODO: Los pacientes fueron distribuidos en de los grupos de acuerdo a la dosis de pipecuronio: Grupo I (0,04 mg.kg-1 y Grupo II (0,05 mg.kg-1. La medicación preanestésica consistió en midazolam (0,1 mg.kg-1 por vía muscular, 30 minutos antes de la operación. La inducción anestésica se obtuvo con propofol (2,5 mg.kg-1 precedido del fentanil (5 µg.kg-1 y del pipecuronio en las dosis de 0,04 y 0,05 mg.kg-1 para los Grupos I y II, respectivamente. Los pacientes se ventilaron con O2 a 100% bajo máscara hasta la reducción de un 75% de la amplitud de la respuesta al estímulo aislado (1 Hz, cuando fueron realizadas la laringoscopía y la intubación traqueal. El isoflurano (0,5 a 1% en mezcla de O2 y N(20 a un 50% para el mantenimiento de la anestesia, fue introducido a continuación de la intubación traqueal. Los pacientes fueron ventilados mecánicamente para mantener el P ET CO2 entre 32 y 36 mmHg. La farmacodinámica del pipecuronio se evaluó por aceleromiografía. RESULTADOS: Los tiempos promedios y desviaciones estándar para el inicio de acción, duración clínica (T1(25% e índice de recuperación (T1(25-75% fueron los siguientes: Grupo I (122,10 ± 4,18 seg, 49,63 ± 9,54 min y 48,21 ± 6,72 min y Grupo II (95,78 ± 8,91 seg, 64,84 ± 13,13 min y 48,52 ± 4,95 min. El inicio de acción, la duración clínica y las condiciones de intubación traqueal fueron significativamente diferentes entre los grupos. CONCLUSIONES: El pipecuronio, en la dosis 0,05 mg.kg-1 puede ser usado en procedimientos de larga duración donde se desee evitar alteraciones cardiocirculatorias.BACKGROUND AND OBJECTIVES: Pipecuronium is a non-depolarizing neuromuscular blocker with similar properties to pancuronium, but without cardiovascular effects. Neuromuscular

  7. Efecto de diferentes dosis de gonadotrofina coriónica equina sobre la respuesta reproductiva de hembras ovinas con un tratamiento para inducción de celos Effect of different doses of equine chorionic gonadotropin on reproductive performance in sheep with oestrus induction treatment cycle

    OpenAIRE

    Catalano, R.; Teruel, M.; J Cabodevila; S Callejas

    2007-01-01

    El objetivo de este trabajo fue comparar el efecto de diferentes dosis de eCG en un tratamiento para inducción de celos en borregas (Ensayo 1) y ovejas (Ensayo 2) (Frisona x Corriedale) en anestro estacional sobre variables reproductivas. Se utilizaron esponjas intravaginales con 60 mg de acetato de medroxiprogesterona por 10 días y al retiro de las mismas se administraron 300 UI (grupo G300) ó 500 UI (grupo G500) de eCG. El porcentaje de celo no fue diferente entre grupos (Ensayo 1 = 100%; E...

  8. Efecto de Diferente Dosis de Lodo de la Crianza de Salmones en el Cultivo de Papa y su Efecto Residual en Ballica Anual Effect of Different Rates of Cage Salmon Sludge on Potato Crop and its Residual Effect on Annual Ryegrass

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    Nolberto Teuber K; Francisco Salazar S; Marta Alfaro V; Aldo Valdebenito B

    2007-01-01

    La producción intensiva de salmones genera residuos orgánicos que tienen un uso potencial en suelos agrícolas, existiendo escasa información publicada de su utilización. El objetivo del presente estudio fue evaluar el efecto de tres dosis de lodo de salmón en el desarrollo del cultivo de papa (Solanum tuberosum) y su efecto residual en ballica anual (Lolium multiflorum). El ensayo se estableció en un suelo Andisol de la serie Osorno (Typic Hapludands), ubicado en Osorno (40º35’S, 73º08’O), Ch...

  9. Dosis óptima económica de nitrógeno en maíz según potencial de producción y disponibilidad de nitrógeno en la región pampeana norte Economic optimal nitrogen rate as affected by yield potential and nitrogen supply in the northern pampas

    OpenAIRE

    Fernando Salvagiotti; Julio Manuel Castellarín; Facundo Javier Ferraguti; Hugo Miguel Pedrol

    2011-01-01

    El maíz es el principal cereal de verano en la Región Pampeana norte de la Argentina donde los suelos presentan una deficiencia crónica de nitrógeno (N). La fertilización nitrogenada en maíz debe optimizar los niveles de N disponible a la siembra (Nds=Nds inic + N fertilizante) para asegurar la máxima rentabilidad y evitar altas dosis que perjudiquen el ambiente. Los objetivos de este trabajo fueron: i) comparar la capacidad de los modelos cuadrático-plateau (CP) y esférico (Esf) para estimar...

  10. Ensayo clínico aleatorizado, controlado, doble ciego, para evaluar la analgesia posparto con morfina epidural: efectividad analgésica de dos dosis diferentes, comparadas con placebo Randomized double-blind controlled clinical trial for the evaluation of post-partum analgesia using epidural morphine: analgesic effectiveness of different dose regimes compared with placebo

    OpenAIRE

    Darío José Perea Solano; José Ricardo Navarro; Pedro Herrera; Viviana Castillo; Andrea González; Andrés García; Jaime Gálvis

    2012-01-01

    Introducción: Estudios previos han demostrado que el manejo convencional del dolor posparto (acetaminofén, AINE) es insuficiente. En nuestro medio se desaprovecha el uso del catéter epidural que es colocado como parte del manejo analgésico de las gestantes en el trabajo de parto. Objetivo: Determinar la eficacia de dosis de 2 mg y de 3 mg de morfina epidurales frente a placebo, empleadas para analgesia durante el posparto vaginal en pacientes que recibieron nalgesia epidural para su trabajo d...

  11. PLANES ESTRATÉGICOS INTEGRALES PARA LA INCORPORACIÓN Y USO DE TIC: CLAVES PARA ADMINISTRAR EL CAMBIO

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    Arturo Ángeles Mancilla

    2012-05-01

    A manera de conclusión se plantea la opción de trabajar conforme a  Planes Estratégicos Integrales para la Incorporación y uso de TIC con la finalidad de obtener resultados más consistentes y optimar esfuerzos en los procesos de cambio.

  12. Raquianestesia contínua com altas doses de anestésicos locais Raquianestesia continua con altas dosis de anestésicos locales Continuous spinal anesthesia with high dose of local anesthetics

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    Luiz Eduardo Imbelloni

    2010-10-01

    éteres intermediarios (catéter por fuera de la aguja y por su baja incidencia de cefalea y síntomas neurológicos, la técnica ha venido ganando credibilidad. El objetivo de este caso es relatar la posible seguridad del uso del nuevo catéter con una gran dosis de bupivacaína hiperbárica al 0,5% con glucosa al 1,6% asociada a la lidocaína al 2% hiperbárica y con glucosa al 1,6%. RELATO DEL CASO: Paciente masculino, de 78 años, 85 kg, 168 cm, estado físico ASA III, hipertenso, con coronariopatía e insuficiencia renal crónica. Candidato a cirugía de voluminosas hernias inguinales bilateral y umbilical, siendo sometido durante una semana a neumoperitoneo para crear espacio. Posteriormente a la venoclisis con catéter 18G, monitorización con cardioscopio, presión arterial no invasiva y oximetria de pulso, fue sedado con 1 mg de midazolam y fentanil 100 µg por vía venosa y colocado en decúbito lateral izquierdo. Sometido a la raquianestesia continua por vía mediana en L3-L4, y conjunto de aguja cortante 27G con catéter 22G. La dosis total de anestésico utilizada en el procedimiento fue 25 mg de bupivacaína al 0,5% (hiperbárica con glucosa al 1,6% y 160 mg de lidocaína al 2% (hiperbárica con glucosa al 1,6% y morfina (100 µg. Paciente con seguimiento hasta el 30º día sin quejidos neurológicos. CONCLUSIONES: Recientemente, la mala distribución del anestésico local a través de microcatéter, se atribuyó a una causa del síndrome de cola de caballo. Este relato de caso mostró que, con la administración de altas dosis de anestésicos hiperbáricos a través del nuevo catéter, no hubo una mala distribución ni el riesgo de síndrome de cola de caballoBACKGROUND AND OBJECTIVES: Better control of the level, intensity, and duration of spinal analgesia represents the greatest advantages of continuous spinal anesthesia. With the advent of intermediate catheters (over-the-needle catheter and its low incidence of headaches and neurological symptoms, the technique has

  13. Metabolic dose-effect relationships of different Pt compounds on growing, pregnant, and lactating rats; Metabolische Dosis-Wirkungsbeziehungen verschiedener Pt-Verbindungen bei wachsenden, graviden und laktierenden Ratten (VPT 04)

    Energy Technology Data Exchange (ETDEWEB)

    Eder, K.; Kirchgessner, M. [Technische Univ. Muenchen, Freising (Germany). Lehrstuhl fuer Tierernaehrung

    1997-12-31

    The fact that humans can take up platinum via the food chain calls for an investigation of the effects of platinum ingestion on the organism. For this purpose a study was carried out on the dose-effect relationships of various platinum compounds using the rat as a model. To take due account of different physiological stages the study included growing, pregnant, and lactating rats. According to present knowledge platinum is primarily emitted in its elemental form by the catalytic converter, i.e. with the formal oxidation number zero, and to a lesser degree in ionic form. Beside elemental platinum the study therefore also involved exposure to PtCl{sub 2} and PtCl{sub 4}. Furthermore, to do justice to the fact that humans and animals take up platinum not only from its primary source but also from plants in the food chain, platinum was also administered as a Pt-II-phytochelatin complex previously isolated from Pt-contaminated material. Study criteria were chosen with a view to obtaining a general indication of potential toxic effects and included parameters such as the live weight curve, haematological status, and platinum accumulation in the body or in specific organs. Of particular interest in pregnant and lactating rats were platinum levels in foetuses and milk. [Deutsch] Ueber die Nahrungskette ist eine alimentaere Aufnahme von Platin durch den Menschen moeglich und erfordert, die Auswirkungen der ingestiven Platinzufuhr auf den Organismus zu untersuchen. Deshalb wurden am Modelltier Ratte Studien zur Dosis-Wirkungsbeziehung verschiedener Platinverbindungen durchgefuehrt. Um den verschiedenen physiologischen Stadien gerecht zu werden, wurden sowohl wachsende wie auch gravide und laktierende Ratten in die Studien einbezogen. Soweit bislang bekannt, wird Platin vorwiegend in der formalen Oxidationsstufe Null als elementares Platin, zu einem geringeren Anteil aber auch in ionischer Form aus der Katalysatoreinheit ausgetragen. Deshalb wurden in den vorliegenden

  14. Effects of Nitrogen on Productivity, Grain Quality, and Optimal Nitrogen Rates in Winter Wheat cv. Kumpa-INIA in Andisols of Southern Chile Efecto del Nitrógeno en Productividad, Calidad del Grano y Dosis Óptimas de Nitrógeno en Trigo Invernal cv. Kumpa-INIA en Andisoles del Sur de Chile

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    Ricardo Campillo

    2010-03-01

    Full Text Available Nitrogen is one of the main inputs of the winter wheat crop (Triticum aestivum L. in southern Chile. Nitrogen efficient management is basic to optimizing its utilization while decreasing pollution risks and operational costs. Crop response and N use efficiency (NUE, defined as the ratio of yield to mineral N supply, regardless of source are important for evaluating N requirements of winter wheat, and reaching maximum and economic yields. The objective of this study was to determine the effect of N rate on grain yield, calculate the N rate that maximizes yield, and estimate the optimal grain yield rate and quality of high-yielding winter wheat cv. Kumpa-INIA. Five annual N rates were evaluated in a randomized complete block design during two successive winter wheat cropping seasons on a Vilcún series soil of the Pachic Melanudands family (Andisol in La Araucania Region, Chile, and subjected to intensive annual crop rotation. Significant effects (P ≤ 0.01 of N rate on grain yield and quality were found. The optimal physical N rate (OPR in both seasons ranged from 290 to 339 kg ha-1, whereas optimal economic N rate (OER ranged from 248 to 274 kg ha-1, with yields between 10.2 and 10.1 t ha-1. Nitrogen use efficiency associated to OER was high in both seasons (36.9 and 41.2 kg grain kg-1 N and fluctuated in similar ranges. Nitrogen rate increased hectoliter weight and grain protein, but decreased NUE.El N es uno de los principales insumos del cultivo de trigo (Triticum aestivum L. en Chile. Su manejo eficiente optimiza las dosis, disminuye los riesgos de contaminación y los costos de producción. La respuesta del cultivo y eficiencia de uso de N (NUE, definida como la razón de rendimiento y suministro de N mineral, independientemente de la fuente son importantes para evaluar los requerimientos de N y alcanzar rendimientos máximos y económicos. El objetivo de este estudio fue determinar el efecto del N en la producción y las dosis que

  15. Reversión del bloqueo neuromuscular residual por atracurio y vecuronio con dosis bajas de neostigmina Reversion of atracurium and vecuronium residual nondepolarising neuromuscular blockade with low doses of neostigmine

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    J.R. Ortiz-Gómez

    2006-08-01

    Full Text Available Objetivos. Comprobar la eficacia de dosis bajas de neostigmina en la reversión del bloqueo neuromuscular no despolarizante residual (BNM-R. Material y Métodos. Se realizó el trabajo con 119 pacientes adultos, ASA I-III, anestesiados con tiopental, fentanilo, O2-N2O-isoflurano y atracurio (n=62 o vecuronio (n=57. Se monitorizó el BNM-R mediante registro electromiográfico del adductor pollicis ante estímulo ulnar tipo tren de cuatro (TOF, considerando recuperación espontánea un TOF-Ratio 75%. En caso contrario se revertía el BNM-R en función del grado de bloqueo (0-1, 2, 3 ó 4 respuestas al TOF con neostigmina (0,035; 0,03; 0,025 ó 0,02 mg/kg y atropina (0,0175; 0,015; 0,0125 ó 0,01 mg/kg respectivamente. Se registró el tiempo de decurarización y los efectos secundarios. Resultados. Los grupos resultaron demográficamente homogéneos, con TOF-Ratio>75% el 25,8 (atracurio y 21,1% (vecuronio, mostrando el resto 0-1 respuestas al TOF (11,3 y 19,2%, 2 (6,5 y 11,5%, 3 (4,8 y 7,6% ó 4 respuestas (51,6 y 50% respectivamente, decurarizándose en 10,5±7 (atracurio y 10,3±6,4 min (vecuronio. Hubo predominio de efectos secundarios en el grupo del atracurio (p=0,027 a expensas de sialorrea, naúseas y vómitos. No se registró ningún caso de recurarización. Conclusiones. La reversión del BNM-R con dosis bajas de neostigmina y atropina ajustadas al grado de bloqueo es efectiva incluso en bloqueos profundos y reduce el riesgo de efectos secundarios de estos fármacos.Objectives. To assess the effectiveness of low doses of neostigmine in the reversion of residual nonpolarising neuromuscular blockade (RNMB. Material and methods. The work involved one hundred and nineteen adult patients, ASA I-III, anaesthetised with fentanyl, thiopental, O2-N2O-isoflurane and atracurium (n=62 or vecuronium (n=57. RNMB was monitored with continuous electromyography of adductor pollicis with TOF stimulation. When TOF-Ratio (TR < 75%, neostigmine 0.035, 0.03, 0

  16. Dosis óptima económica de nitrógeno en maíz bajo siembra directa en el sudeste bonaerense Economic optimal nitrogen rate for corn under no-tillage in southeast Buenos Aires Province

    Directory of Open Access Journals (Sweden)

    A Pagani

    2008-12-01

    Full Text Available La fertilización nitrogenada en el cultivo de maíz es una práctica habitual en el SE bonaerense, sin embargo es escasa la información local para definir la dosis de nitrógeno (N que responde al máximo beneficio económico. El objetivo de este trabajo fue determinar la dosis óptima económica (DOE del fertilizante nitrogenado para el cultivo de maíz bajo SD en el SE bonaerense, seleccionando el modelo matemático y momento de fertilización más adecuado. Además, se comparó el efecto de la relación de precios N-grano de maíz y la potencialidad del año sobre la definición de la DOE. Se utilizó información de 23 experimentos de fertilización nitrogenada, 15 al momento de la siembra (SI y 8 en el estadio de seis hojas (V6, para el período 1994-2005 con condiciones ambientales contrastantes (años con diferente potencialidad. Si bien no se determinó un criterio estadístico para seleccionar el modelo más apropiado, el cuadráticoplateau arrojó los resultados más racionales desde el punto de vista agronómico. Para el modelo cuadrático-plateau, se observó que el efecto de la potencialidad del año produjo variaciones en la DOE de 59 y 54 kg N ha-1 para el momento de SI y V6, respectivamente; mientras que el efecto de la relación de precios produjo variaciones tan solo de 30 y 23 kg N ha-1 para el momento de SI y V6, respectivamente. Se concluye que el modelo cuadrático-plateau produce los resultados de mayor racionalidad agronómica. Además, el estadio de V6 se mostró como el momento más apropiado para la fertilización tanto desde la perspectiva económica como ambiental y la potencialidad del año condicionó la DOE en mayor medida que la relación de precios.Nitrogen fertilization in corn under no-till is a common practice in SE Buenos Aires Province; however, there is insufficient local information to define the nitrogen (N rate that corresponds to the maximum economic benefit. The aim of this work was to optimize the

  17. Observation of supramolecular aggregation by dosy NMR

    Czech Academy of Sciences Publication Activity Database

    Šaman, David; Wimmer, Zdeněk; Kolehmainen, E.

    Tatranská Lomnica : Slovak National NMR Centre. Slovak Chemical Society, 2011 - (Liptaj, T.; Imrich, J.; Kovaľaková, M.; Olčák, D.). s. 56-56 ISBN 978-80-89284-77-1. [Magnetic Moments in Central Europe. 16.03.2011-20.03.2011, Tatranská Lomnica] R&D Projects: GA MŠk 2B06024 Institutional research plan: CEZ:AV0Z40550506 Keywords : difusion * NMR Subject RIV: CC - Organic Chemistry

  18. Dose. Detriment. Limit assessment; Dosis. Schadensmass. Grenzwertsetzung

    Energy Technology Data Exchange (ETDEWEB)

    Breckow, J. [Technische Hochschule Mittelhessen, Giessen (Germany). Inst. fuer Medizinische Physik und Strahlenschutz (IMPS)

    2015-07-01

    One goal of radiation protection is the limitation of stochastic effects due to radiation exposure. The probability of occurrence of a radiation induced stochastic effect, however, is only one of several other parameters which determine the radiation detriment. Though the ICRP-concept of detriment is a quantitative definition, the kind of detriment weighting includes somewhat subjective elements. In this sense, the detriment-concept of ICRP represents already at the stage of effective dose a kind of assessment. Thus, by comparing radiation protection standards and concepts interconvertible or with those of environment or occupational protection one should be aware of the possibly different principles of detriment assessment.

  19. A mixture of Lactobacillus plantarum CECT 7315 and CECT 7316 enhances systemic immunity in elderly subjects: A dose-response, double-blind, placebo-controlled, randomized pilot trial Una mezcla de Lactobacillus plantarum CECT 7315 y CECT 7316 mejora la inmunidad sistémica en ancianos: Un ensayo aleatorio piloto, de dosis-respuesta, doble ciego y controlado con placebo

    Directory of Open Access Journals (Sweden)

    J. Mañé

    2011-02-01

    los efectos de una mezcla de dos nuevas cepas probióticas de Lactobacillus plantarum -CECT 7315 y 7316- sobre la inmunidad sistémica en ancianos. Métodos: 50 ancianos institucionalizados se aleatorizaron, en un diseño a doble-ciego, para recibir durante 12 semanas 1 5·10(8 ufc/día de L. plantarum CECT7315/ 7316 ("dosis baja de probiótico" (n = 13, 2 5·10(9 ufc/día de la mezcla probiótica ("dosis alta de probiótico" (n = 19, o 3 placebo (n = 15. Se determinaron las subpoblaciones leucocitarias y los niveles de citokinas (IL-1 , IL-10, TGF-β1 en sangre venosa periférica basalmente, al final del tratamiento (sem. 12 y al final del seguimiento (sem. 24. Se registró la tasa de infecciones y la mortalidad. Resultados: Tras el tratamiento, la dosis alta de probiótico indujo aumentos significativos en los porcentajes de células potencialmente T-supresoras (CD8+CD25+ y NK (CD56+CD16+ activadas, en tanto que la dosis baja aumento los linfocitos T-colaboradores activados (CD4+CD25+, los linfocitos B (CD19+, y las células presentadoras de antígeno (HLA-DR+. Asimismo, la concentración plasmática de TGF-β1 disminuyó tras el tratamiento con ambas dosis de probiótico. La mayor parte de estos cambios se mantuvieron 12 semanas después de suspender el tratamiento. La incidencia de infecciones durante el tratamiento mostró una tendencia significativa a ser menor con la dosis alta de probiótico, mientras que se observó una tendencia significativa a que la mortalidad fuera mayor el grupo placebo vs. ambos grupos tratados con probiótico. Conclusiones: Dependiendo de la dosis, L. plantarum CECT7315/7316 tiene distintos efectos inmunoestimulantes en ancianos. Dichos efectos podrían contribuir a una mejor evolución clínica.

  20. Determining the optimal dose of Fenton reagent in a leachate treatment by Fenton-adsorption; Determinacion de la dosis optima de reactivo Fenton en un tratamiento de lixiviados por Fenton-adsorcion

    Energy Technology Data Exchange (ETDEWEB)

    Mendez Novelo, Roger Ivan; Pietrogiovanna Bronca, Jose Alfredo; Santos Ocampo, Beatriz; Sauri Riancho, Maria Rosa; Giacoman Vallejos, German; Castillo Borges, Elba Rene [Universidad Autonoma de Yucatan, Facultad de Ingenieria, Merida, Yucatan (Mexico)]. E-mail: mnovelo@uady.mx

    2010-07-01

    tipo Fenton-adsorcion con el que se obtuvieron mejores resultados que con otros tratamientos fisicoquimicos o biologicos reportados en la literatura. El proceso Fenton consiste en tratar la carga contaminante con una combinacion de H{sub 2}O{sub 2} y FeSO4 en condiciones acidas. Se evaluo si la filtracion de los lodos producidos durante el proceso Fenton es un proceso mas eficiente que la sedimentacion. Se determino el tiempo de contacto optimo de la oxidacion Fenton, asi como la dosis optima de los reactivos usados en funcion de la DQO del lixiviado, mediante la determinacion de las mejores relaciones [Fe{sup 2+}]/[H{sub 2}O{sub 2}] y [DQO]/[H{sub 2}O{sub 2}]. Despues de optimizar el proceso, se filtraron las muestras oxidadas y se ensayo la adsorcion mediante columnas empacadas con carbon activado granular. Se concluyo que el lodo generado por el proceso Fenton se remueve mas eficientemente mediante filtracion que por sedimentacion. Los tiempos de contacto optimos fueron de 5 min para la remocion de la DQO y una hora para la remocion de color, tiempo elegido para proteger el carbon activado. Las mejores relaciones para [Fe{sup 2+}]/[H{sub 2}O{sub 2}] y [DQO]/[H{sub 2}O{sub 2}] fueron 0.6 y 9, respectivamente. La eficiencia maxima de remocion despues del proceso de adsorcion fue de 98.9 % para la DQO y 100 % para el color. El indice de biodegradabilidad final alcanzado despues de las pruebas de Fenton-adsorcion fue de 0.24.

  1. Necrosis avascular de ambas caderas y rodillas en una paciente con colitis ulcerosa tratada prolongadamente con corticoides a dosis altas A vascular necrosis of both hips and knees in a patient with ulcerative colitis treated for a long term with high-dose corticosteroids

    Directory of Open Access Journals (Sweden)

    A. Vidal Casariego

    2006-02-01

    Full Text Available INTRODUCCIÓN: La necrosis avascular representa la muerte del tejido óseo por fallo de su vascularización, y se asocia principalmente al uso de corticoides a dosis elevadas durante tiempo prolongado. CASO CLÍNICO: Una paciente de 25 años tratada con glucocorticoides a altas dosis durante 7 meses por colitis ulcerosa presenta dolor en ambas rodillas y movilidad limitada de caderas y rodillas. En la radiografía simple y la resonancia nuclear magnética (RNM se observó necrosis avascular en dichas articulaciones; la densitometría ósea demostró osteopenia en cabeza femoral y osteoporosis lumbar. DISCUSIÓN: Presentamos un caso llamativo por la amplia afectación articular (ambas caderas y rodillas con presencia simultánea de osteoporosis y osteopenia en una paciente joven tratada con corticoides por colitis ulcerosa. Es necesario recomendar el uso prudente de los glucocorticoides, prescribiendo la dosis mínima necesaria y durante el menor tiempo que sea posible para controlar la enfermedad de base.INTRODUCTION. Avascular necrosis represents the bone tissue death from vascularization failure, and it is mainly associated with the use of high-dose corticosteroids for a long time. CLINICAL CASE. A 25 years old female patient treated with high-dose corticosteroids for 7 months for ulcerative colitis presents with both knees pain and limited hip and knee motility. In a plain X-ray and in nuclear magnetic resonance imaging (MRI avascular necrosis was observed at these joints. Bone densitometry showed osteopenia at the femoral head and lumbar osteoporosis. DISCUSSION. We present a striking case for its large involvement of the joints (both knees and hips with simultaneous osteoporosis and osteopenia in a young patient treated with corticosteroids for ulcerative colitis. It is necessary to recommend the judicious use of glucocorticoids, prescribing the minimal necessary dose and for the least amount of time necessary to control the underlying

  2. Toxicidad oral a 60 días del aceite de sacha inchi (Plukenetia volubilis L. y linaza (Linum usitatissimum L. y determinación de la dosis letal 50 en roedores Oral toxicity at 60-days of sacha inchi oil (Plukenetia volubilis L. and linseed (Linum usitatissimum L., and determination of lethal dose 50 in rodents

    Directory of Open Access Journals (Sweden)

    Arilmi Gorriti

    2010-09-01

    Full Text Available Objetivos. Evaluar la toxicidad oral a 60 días y determinar la dosis letal 50 (DL 50 de los aceites crudos de sacha inchi (Plukenetia volubilis L. y linaza (Linum ussitatisimum en ratas Holtzman y en ratones cepa Balb C57, respectivamente. Materiales y métodos. Para la evaluación de la toxicidad oral a dosis repetida por 60 días se utilizó 24 ratas macho Holtzman divididos en tres grupos de ocho cada uno, los grupos fueron: solución salina fisiológica 4 mL/kg (SSF, aceite de sacha inchi 0,5 mL/kg (SI05 y aceite de linaza 0,5 mL/kg (L05, durante el experimento se controló semanalmente el peso corporal y signos de toxicidad en los grupos investigados, así como colesterol total, HDL, triglicéridos, glucosa, urea, TGP y fosfatasa alcalina a los 30 y 60 días de iniciado el experimento. Para la evaluación de la DL50 se usó ratones macho cepa Balb C57 en grupos de diez animales, se administró por vía oral dosis crecientes de aceites crudos hasta alcanzar 1 mL/kg (37 g/kg; Resultados. Los parámetros séricos en las ratas indican que no existe toxicidad alguna a los 60 días y que la administración de los aceites disminuyeron los niveles de colesterol, triglicéridos e incrementaron el HDL con respecto al grupo control. La DL50 muestra que los aceites crudos de sacha inchi y linaza presentan dosis por encima de los 37 g/kg de masa corporal. Conclusiones. Los aceites de sacha inchi y linaza son inocuos a 60 días y presentan una DL50 por encima de los 37 g/kg de animal.Objectives. To evaluate the oral toxicity at 60 days and to determine the lethal dose 50 (LD 50 of raw sacha inchi (Plukenetia volubilis L. and linseed (Linum ussitatisimum oils in Holtzman rats and mice of the strain Balb C57 respectively. Materials and methods. For the evaluation of the oral toxicity of repeated doses for 60 days, 24 male Holtzman rats were used, divided in three groups of 8 each, the groups were: physiologic saline solution 4 mL/kg (FSS, sacha inchi oil

  3. Efecto de Diferente Dosis de Lodo de la Crianza de Salmones en el Cultivo de Papa y su Efecto Residual en Ballica Anual Effect of Different Rates of Cage Salmon Sludge on Potato Crop and its Residual Effect on Annual Ryegrass

    Directory of Open Access Journals (Sweden)

    Nolberto Teuber K

    2007-12-01

    Full Text Available La producción intensiva de salmones genera residuos orgánicos que tienen un uso potencial en suelos agrícolas, existiendo escasa información publicada de su utilización. El objetivo del presente estudio fue evaluar el efecto de tres dosis de lodo de salmón en el desarrollo del cultivo de papa (Solanum tuberosum y su efecto residual en ballica anual (Lolium multiflorum. El ensayo se estableció en un suelo Andisol de la serie Osorno (Typic Hapludands, ubicado en Osorno (40º35’S, 73º08’O, Chile. Los tratamientos fueron tres dosis de lodo (50, 100 y 200 t ha-1, un control (sin fertilización orgánica e inorgánica y un tratamiento de fertilización inorgánica. El lodo se incorporó al suelo, posteriormente se plantó papa cv. Yagana-INIA y después de la cosecha se sembró ballica anual cv. Sabalan. El rendimiento de papa con fertilización inorgánica fue 64,3 t ha-1, superior a los resultados obtenidos con las dosis de lodo y el control (P ≤ 0,05. No hubo diferencias estadísticas (P > 0,05 entre las distintas dosis de lodo evaluadas (45,6 a 47,5 t ha-1 y tampoco con el control (39,4 t ha-1. No se observaron diferencias (P > 0,05 en el peso por tubérculo, pero el número de tubérculos por planta fue diferente (P ≤ 0,05. El rendimiento de ballica anual fue significativamente diferente (P ≤ 0,05 en los tratamientos fertilizados comparados con el control. El lodo no afectó la emergencia ni el desarrollo de los cultivos, pero incrementó el contenido de P Olsen y la suma de bases de intercambio en el suelo.Intensive salmon farming generates organic residues which have a potential use in agricultural soils. The objective of this study was to evaluate the effect of three salmon sludge rates on potato (Solanum tuberosum crop development and its residual effect on annual ryegrass (Lolium multiflorum. The field experiment was carried out on an Andisoil from Osorno Serie (Hapludands, located in Osorno (40º35’S, 73º08’W, Chile

  4. Efficacy of Different Rates of Sexual Pheromoneof Phthorimaea operculella (Zeller (Lepidoptera: Gellechiidae in Maleso of PotatoTuber Moth Captures Efectividad de Distintas Dosis de Feromona Sexual de Phthorimaea operculella (Zeller (Lepidoptera: Gelechiidae en la Captura de Machos de Polilla de la Papa

    Directory of Open Access Journals (Sweden)

    Patricia Larraín S

    2007-12-01

    otros insectos. Con el fin de evaluar la efectividad de diferentes dosis de feromona en la captura de machos de P. operculella, para su futura utilización como técnica de trampeo masivo, se realizaron dos ensayos en un diseño de bloques completos al azar, durante las temporadas verano 2003-2004, y primavera 2004, en el Valle del Elqui, IV Región, Chile. Dosis de 0,2; 0,5; 1; 2 y 5 mg y 0,05; 0,1; 0,2 y 0,5 mg de la mezcla de las feromonas sexuales sintéticas de la polilla de la papa (E4-Z7 Tridecadienil acetate, and E4-Z7-Z10 Tridecatrienil acetate, en tasa de 1:1,5 por trampa. Los resultados obtenidos indican que la mayor captura de machos ocurre con dosis de 0,2 y 0,5 mg de feromona por trampa. Con la optimización de la dosis de feromona por trampa, los estudios continuarán para proponer la técnica de capturas masivas de polilla de la papa, como un método de control no químico y ambientalmente seguro.

  5. Infusão intravenosa de vasopressina causa efeitos cardiovasculares adversos dose-dependentes em cães anestesiados Infusión intravenosa de vasopresina causa efectos cardiovasculares adversos dependientes de la dosis en canes anestesiados Vasopressin intravenous infusion causes dose dependent adverse cardiovascular effects in anesthetized dogs

    Directory of Open Access Journals (Sweden)

    Luiz Cláudio Martins

    2010-02-01

    que 0,01 U/kg/min forem necessárias.FUNDAMENTO: La arginina-vasopresina (AVP ha sido ampliamente utilizada en el tratamiento del choque vasodilatador. No obstante, hay muchos aspectos relativos a su uso clínico, especialmente en altas dosis, pues su utilización puede estar asociada a efectos cardíacos adversos. OBJETIVO: Investigar los efectos cardiovasculares de la AVP en infusión IV continua en los parámetros hemodinámicos en canes. MÉTODOS: Dieciséis canes saludables sin raza definida, anestesiados con pentobarbital, recibieron un catéter intravascular y fueron aleatoriamente designados para dos grupos: control (solución salina - placebo; n=8 y AVP (n=8. El grupo del estudio recibió infusión de AVP por tres períodos consecutivos de 10 minutos a dosis logarítimicamente progresivas (0,01; 0,1 y 1,0 U/kg/min, a intervalos de 20 minutos La frecuencia cardíaca (HR y las presiones intravasculares fueron registradas continuamente. El débito cardíaco fue medido a través del método de termodilución. RESULTADOS: No se observó ningún efecto hemodinámico significativo durante la infusión de 0,01 U/kg/min de AVP, pero con las dosis más altas, de 0,1 y 1,0 U/kg/min, hubo un aumento progresivo en la presión arterial media (PAM y en el índice de resistencia vascular sistémica (IRVS, con significativa disminución en la frecuencia cardíaca (FC e índice cardíaco (IC. Con la dosis 1,0 U/kg/min, también se observó un aumento significativo en el índice de resistencia vascular pulmonar (IRVP, principalmente debido a la disminución en el IC. CONCLUSIÓN: La AVP en dosis entre 0,1 y 1,0 U/kg/min resultó en significativos aumentos en la PAM y en el IRVS, con efectos inotrópicos y cronotrópicos negativos en animales saludables. Aunque estas dosis sean de 10 a 1.000 veces mayores que las rutinariamente utilizadas en el tratamiento del choque vasodilatador, nuestros datos confirman que la AVP debería ser usada cuidadosamente y bajo rígido monitoreo

  6. Optimal dosis af bendroflumetiazid ved hypertension. En randomiseret dobbeltblind dosis-responsundersøgelse

    DEFF Research Database (Denmark)

    Carlsen, J E; Køber, L; Torp-Pedersen, C T;

    1990-01-01

    participated in this randomized, double-blind placebo-controlled parallel group study. The patients were treated with either 0, 1.25, 2.5, 5.0 or 10 mg bendrofluazide daily for 12 weeks. Blood pressure was measured with a random zero sphygmomanometer and a Tricuff. Compliance was checked by tablet counts. The...... mean decreases in diastolic blood pressure were 3.5, 9.8, 10.8, 10.1 and 10.8 mmHg in the five treatment groups respectively. The heart rates were unchanged in all groups. Dose-effect relations were demonstrated for potassium, urate, glucose, cholesterol and apolipoprotein B. The lowest dose of......The object of this study was to determine the clinically relevant dose of bendrofluazide for the treatment of arterial hypertension. A material of 257 male and female subjects, age 25-70 years, with sitting diastolic blood pressures between 100-120 mmHg after six weeks of placebo treatment...

  7. Eficacia y tolerabilidad de esteroides epidurales vs. Dosis bajas de esteroides mas metamizol mas D-propoxifeno administrados por vía paravertebral en pacientes con síndrome post-laminectomía Efficacy and tolerability of epidural steroids vs low doses of steroids plus metamizol plus propoxyphene administered paravertebrally for postaminectomy syndrome patients

    Directory of Open Access Journals (Sweden)

    J. A. Aldrete

    2006-10-01

    Full Text Available El reconocimiento de la acción antinociceptiva de los antiinflamatorios no esteroideos (AINEs ha motivado su combinación con dosis moderadas de opiáceos con objeto de obtener una mayor analgesia, mientras que se reduce la necesidad de emplear dosis altas de esteroides. Un grupo de 142 pacientes adultos, que habían desarrollaron radiculopatía y lumbalgia después de la primera discectomia, en los que se demostró radiologicamente fibrosis y cicatriz periradicular, en el sitio de operación, se dividieron en dos subgrupos al azar. El grupo A (69 pacientes, fue tratado con inyecciones peridurales de 80 mg de metilprednisolona (MTP en 3ml de bupivacaína 0.25% (BPV después de obtener medidas controles de dolor, actividad física y la ingestión de medicamentos usando el Esquema del Progreso del Dolor, obteniendo un promedio control antes de iniciar el tratamiento. El grupo B (73 pacientes fue tratado con inyecciones paravertebrales en los niveles L4-L5 y L5-S1, de 5 mg de metamizol (DPN, y 12.5 mg de propoxifeno (PPX agregados a 10 mg de MTP y 1 ml de BPV 0.5%, bilateralmente en cuatro sesiones. Las mismas evaluaciones se llevaron a cabo cada 3 semanas después de cada tratamiento. Todos los pacientes mejoraron clínicamente, sin observarse diferencias significativas entre ambos grupos; Cuando se compararon los valores totales de mejoría clínica, se observaron los niveles controles significativos (p> 0.05 solo cuando se compararon con las mediciones de mejoría clínica, tomadas antes de iniciar el tratamiento en ambos grupos. Se presentaron efectos secundarios como incremento de peso, equimosis, edema fascies lunar y eritema facial en los pacientes del grupo A. La punción dural incidental (3 y cefalea por punción dural (2 se encontraron solo en el grupo A. Un paciente requirió ser tratado con un parche hematico epidural. Ocurrió parestesia en 1 paciente de cada grupo. No se encontraron diferencias significativas de mejoria entre grupos

  8. Diagnostic and therapeutic perspectives in nuclear medicine: radiolabelled biomolecules; Perspectivas diagnosticas y terapeuticas en medicina nuclear: biomoleculas radiomarcadas

    Energy Technology Data Exchange (ETDEWEB)

    Ferro F, G. [Gerencia de Aplicaciones Nucleares en la Salud. ININ, 11801 Mexico D.F. (Mexico); Murphy, C.A. de; Pedraza L, M. [Departamento de Medicina Nuclear. Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran, Mexico D.F. (Mexico); Melendez A, L. [Facultad de Medicina, UAEM, 50000 Toluca, Estado de Mexico (Mexico)

    2003-07-01

    From their beginning, the radiopharmaceuticals chemistry has gone to the study of the molecular chemistry. The radiopharmaceuticals are only in their capacity to detect such specific biochemical places as the receivers and the enzymes. With the recent obtaining of the complete structural sequence of the genome, it doesn't fit doubt of the importance that they have acquired the molecular images for the study from the genetic information to the alterations phenotypic in the chemistry of the human body. So, the future of the diagnostic and therapeutic nuclear medicine, practically is based in the study of protein fragments, peptide structures and chains of DNA radiolabelled for the study of the metabolism In vivo. These investigations represent a substantial change in those paradigms of the pharmaceutical development, when using the own organic capacities as source of medications, instead of considering to the organism like a simple assay tube where molecules act, like they are most of the traditional medications. The investigation of new techniques to design complex stable of Tc-99m, Re-188, Lu-177, Y-90 and Dy-166/Ho-l66 with biomolecules that don't alter the specificity and in general the molecular properties of the same ones. it is a topic of world interest in the environment of the radiopharmaceutical chemistry. In this work some achievements and perspectives are presented on those main diagnostic and therapeutic radiopharmaceuticals of third generation. (Author)

  9. La expresión plástica de Louise Bourgeois. Estrategias feministas para una praxis terapeutica.

    OpenAIRE

    Jiménez Arenas, Isabel Mª

    2001-01-01

    RESUMEN Este estudio nace desde tres areas de investigación: la estetica feminista, la terapia artística y la expresión plastica, partiendo de la obra de la artista Louise Bourgeois. El primer capítulo, Influencia feminista en Louise Bourgeois, considera la estética y crítica feministas en relación al postmodernismo, el feminismo y la historia. Por una parte, el trabajo de Bourgeois se aprecia bajo la relación entre semiótica, filosofía, sociología, psicología y estética. Por otra parte...

  10. Intussusception in children: imaging evaluation and therapeutic approach; Intussuscepcao em criancas: avaliacao por metodos de imagem e abordagem terapeutica

    Energy Technology Data Exchange (ETDEWEB)

    Cunha, Fabio Motta da; Figueiredo, Sizenildo da Silva; Nobrega, Bruno Barcelos da; Monteiro, Soraya Silveira; Lederman, Henrique Manoel [Universidade Federal de Sao Paulo (UNIFESP/EPM), SP (Brazil). Dept. de Diagnostico por Imagem]. E-mail: brunoradiol@hotmail.com; Oliveira, Galba Leite [Irmandade Santa Casa de Misericordia de Sao Paulo, SP (Brazil). Dept. de Diagnostico por Imagem

    2005-05-15

    Intussusception is a medical emergency that occur with higher frequency in children under 2 years of age. Diagnosis can be difficult as the classical triad of abdominal pain, jelly stools and palpable abdominal mass is seen in less than 50% of the patients. However, the diagnosis of intussusception can be established with variable degree of accuracy using plain abdominal x-ray films, ultrasound, computed tomography or barium (or air/saline) enema. Some of these imaging methods are also useful during treatment of this condition. The authors present a review of the literature and a pictorial essay of the imaging findings in patients with intussusception. In addition, a discussion on the current and controversial issues related to the treatment of intussusception is presented. (author)

  11. Evaluación de diferentes dosis y métodos de aplicación de insecticidas sistémicos para el control del minador de la hoja de los cítricos Phyllocnistis citrella Stainton en plantas de limonero Evaluation of different doses and application methods of systemic insecticides to control citrus leafminer Phyllocnistis citrella Stainton on lemon plants

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    Hernán Salas

    2008-06-01

    Full Text Available El minador de la hoja de los cítricos, Phyllocnistis citrella Stainton, afecta severamente las brotaciones de los limoneros provocando un daño directo importante de diciembre a marzo. Las galerías producidas por la larva son vías de entrada para patógenos, causando daños indirectos. Las plantas jóvenes son las más afectadas. Diversos productos químicos aplicados al follaje controlan eficazmente al minador, pero el período de control es muy breve, siendo necesario pulverizar con frecuencia para un buen control de la plaga. El objetivo de esta experiencia fue evaluar la efectividad de imidacloprid y tiametoxam en diferentes dosis aplicados al tronco y al suelo ("drench" en el control del minador de la hoja de los cítricos. Se ensayaron dos formulaciones de imidacloprid, en aplicaciones al suelo y al tronco, en un rango de dosis entre 0,1 a 0,7 g i.a/cm de diámetro de tronco y tiametoxam a 0,25 g i.a./cm de diámetro de tronco en aplicaciones al suelo solamente. Las evaluaciones se realizaron a partir del recuento de hojas con galería activas del minador. Posteriormente se estimó el porcentaje de área foliar dañada. Todos los tratamientos controlaron la plaga. En plantas de tres años de edad los niveles más elevados de control se obtuvieron con 0,25, 0,35 y 0,7 g i.a. de imidacloprid y 0,25 g i.a. de tiametoxam aplicados en "drench" con un daño foliar menor al 2% obtenido a los 100 días de aplicado. A los cuatro años, solo las dosis de 0,35 y 0,70 g i.a. de imidacloprid mantuvieron esos niveles aceptables de control. Los tratamientos al tronco tuvieron menor residualidad y mostraron mayor daño foliar que los tratamientos en "drench".The citrus leafminer, Phyllocnistis citrella Stainton, affects lemon flushes severely, producing direct damages from December to March. Winding mines allow pathogens to access the plant, causing indirect damages. Young plants are the most affected. Several chemical products sprayed on citrus

  12. Clinical application of Chamomilla recutita in phlebitis: dose response curve study Aplicación clínica de la Chamomilla recutita en flebitis: estudio de la curva dosis-respuesta Aplicação clínica da Chamomilla recutita em flebites: estudo de curva dose-resposta

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    Paula Elaine Diniz dos Reis

    2011-02-01

    Full Text Available This experimental and dose-response curve study aimed to carry out the quality control of the Chamomilla recutita sample, as well as to estimate the ideal dose, for anti-inflammatory effect, of the extract of its capitula, in patients with phlebitis due to peripheral intravenous infusion of antineoplastic chemotherapy and to evaluate the toxicity of this extract in human beings. The therapeutic efficacy, concerning the anti-inflammatory potential, of different doses of Chamomilla recutita extract were analyzed and compared in 25 patients. The time of regression of phlebitis was shorter for groups with 2.5% concentration (mean=29.2h, standard deviation = 8.98 and 5% concentration (mean = 38.8h, standard deviation = 17.47. Local toxicity was almost not observed. This research contributes to the innovation of the nursing clinical practice, since it suggests an alternative for the treatment of phlebitis through the clinical use of phytotherapeutic drugs.En este estudio, se buscó realizar el control de calidad de la muestra de Chamomilla recutita, así como estimar la dosis ideal, para efecto antiinflamatorio, de la infusión de sus inflorescencias, en pacientes con flebitis proveniente de introducción intravenosa periférica de quimioterapia antineoplásica y evaluar la toxicidad de esta infusión en los seres humanos. Se trata de estudio experimental, del tipo curva dosis-respuesta, en el cual fue analizada y comparada la eficacia terapéutica, en cuanto al potencial antiinflamatorio, de diferentes dosis de la infusión de la Chamomilla recutita en 25 pacientes. El tiempo de regresión de la flebitis fue menor para los grupos con concentración 2,5% (promedio = 29,2h, desviación estándar = 8,98 y 5% (promedio = 38,8h, desviación estándar = 17,47 y prácticamente no se observó toxicidad local. Esta investigación contribuye para la innovación de la práctica clínica en enfermería, una vez que sugiere una alternativa para el tratamiento de

  13. Alteraciones histológicas en riñones de ratas, inducidas por dosis bajas del veneno de la serpiente Bothrops asper. - Histological injuries in rat’s kidneys induced to low dose of snake’s poison Bothrops asper.

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    Reyes, Adriana

    2009-09-01

    Full Text Available ResumenEl objetivo del trabajo fue demostrar que dosis bajas del veneno deBothrops asper pueden causar patologías renales que se acentúancon el tiempo de exposición al veneno, especialmente a nivelglomérular. Se emplearon cinco grupos de ratas de cinco individuoscada uno, los cuales fueron inoculados con una dosis de veneno de2.1µg/g de peso (por vía intraperitoneal, con adición de un grupocontrol, al cual se le inyectó solución salina. A los animales se lespracticó la eutanasia secuencialmente (1, 48, 96, 144 y 288 horas.En cada tiempo se extrajeron los riñones del grupo seleccionado, paraprocesarlos con técnicas de coloración (HE – PAS. Con el diagnósticohistopatológico se evidenció en la primera hora gloméruloscongestionados con tumefacción, después de 48 horas se presentóuna glomérulonefritis, seguida de un colapso glomerular a las 96horas. Las patologías se evidenciaron mas en los últimos períodos deexperimentación; a las 144 horas se observó glomérulonefritismembranosa y proliferativa endocapilar culminando con la desaparición de la cápsula de Bowman y la estructura total del glomérulo a las 288 horas. Se concluye que cantidades bajas del veneno pueden causar patologías renales progresivas con el paso del tiempo.SummaryAim of this work was to demonstrate that low doses of Bothropsasper venom can cause pathologies that progress over time on therenal tissue, at the glomerular level especially. Five groups of ratsconsisting of five individuals were used and a single dose of poison2.1µg/g in weight was injected. Control group was injected withsaline solution. Euthanasia sequentially was practiced (1, 48, 96, 144and 288 hours. In each time was extracted the kidneys of groupselection, to procession with color’s techniques (HE – PAS.Histopathological diagnostic evidenced congested glomeruli withswelling in the first hour, after 48 hours a glomerulonephritis waspresented, followed by a collapsed glomerular at

  14. Evaluación de los cambios ocasionados en espermatozoides bovinos por variaciones en el manejo de las dosis durante su manipulación en inseminación artificial Evaluation of changes ocassioned by changes in bovine sperm in the management of dose during handling artificial insemination

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    S.F. Bernardi

    2011-12-01

    Full Text Available Considerando el disímil manejo al que las dosis son sometidas durante el descongelado y antes de la inseminación, el objetivo del presente trabajo fue determinar el efecto que estos cambios producen sobre distintas características morfológicas y funcionales de los espermatozoides afectando la calidad del semen a inseminar. Se utilizaron muestras de un toro Holando Argentino, procesadas y congeladas en pajuelas de 0,5 cc utilizando un diluyente semidefinido. El análisis de la motilidad se realizó mediante el uso de Sperm Vision, la funcionalidad de la membrana plasmática mediante una prueba HOST y la integridad del acrosoma bajo microscopio de contraste de fases. Los cambios de protocolo que llevaron a una calidad no aceptable para inseminar (según normas ISO 9002 se refirieron a cambios bruscos de temperatura de descongelado y del tiempo de inmersión, así como demoras en efectivizar la inseminación una vez descongelada la dosis y en retirar la pajuela del termo de nitrógeno. Esta misma situación se evidenció al analizar la funcionalidad de la membrana plasmática. La integridad del acrosoma fue mayor al descongelar utilizando temperaturas altas (55, 75 y 95°C.The aim of this work was to determine the effect of the changes that doses undergo during thawing and before insemination due to a dissimilar handling of them. Focus was placed on the effects on various morphological and functional characteristics of spermatozoa which affect the quality of the semen to be inseminated. Samples from an Holando Argentine bull were employed, processed and frozen in 0.5cc straws using a semidefined diluent. Sperm motility was performed with Sperm Vision, plasmatic membrane functionality was tested with a HOST test and acrosome integrity under phase contrast microscope. Protocol changes that led to an unacceptable quality for insemination -according to ISO 9002- were related to abrupt thawing temperature changes and immersion time as well as to

  15. Detectors for Quality Assurance in Hadrontherapy

    OpenAIRE

    2014-01-01

    La terapia de hadrones es actualmente una realidad médica en oncología de radiación y una técnica probada en la lucha contra el cáncer. Hoy en día, el uso de la terapia de hadrones está ampliamente extendido en el tratamiento de pacientes con tumores profundos, no operables o resistentes a la radioterapia, debido a la ventaja de administrar una alta dosis de radiación con respecto al volumen del tumor. De esta forma se obtiene un mejor del control y protección del tejido circundante comparado...

  16. Efectividad y seguridad de la viscosuplementación con dosis única de ácido hialurónico estabilizado de origen no animal (NASHA para el tratamiento del dolor secundario a gonartrosis Efficacy and safety of single intra-articular injection of non-animal stabilized hyaluronic acid (NASHA for gonarthrosis pain treatment

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    M. M. Monerris Tabasco

    2012-10-01

    Full Text Available Objetivos: valorar la efectividad y seguridad de la inyección de dosis única de ácido hialurónico estabilizado de origen no animal (NASHA para el tratamiento del dolor secundario a gonartrosis. Material y métodos: se han incluido un total de 37 pacientes afectos de gonartrosis diagnosticada previamente por el Traumatólogo/Reumatólogo en los que ha fracasado el tratamiento conservador y/o que no son tributarios de tratamiento quirúrgico. Se les ha efectuado una infiltración en dosis única de ácido hialurónico estabilizado no animal (NASHA, Durolane®. Se han recogido datos demográficos, efectos adversos e intensidad del dolor (valorada mediante escala verbal numérica y puntuación en los cuestionarios Western Ontario and McMaster Universities Osteoartritis Index (WOMAC y Barthel -basal, a las 2 semanas, a los 3 meses y a los 6 meses de la infiltración-. Se ha considerado efectiva una disminución ≥ 30% durante más de 3 meses en las puntuaciones basales. Resultados: los pacientes son mayoritariamente mujeres (83,8%, con una edad media de 72,8 años (desviación típica -S- = 8,4 e índice de masa corporal medio (IMC 31,9 (S = 6,9. La rodilla infiltrada es izquierda en el 51,7%, derecha en el 41,4% y bilateral en el 6,9% de los pacientes. Han presentado efectos adversos en forma de artralgias bien toleradas el 11,1% de los pacientes. En base a los resultados, la infiltración con dosis única de ácido hialurónico estabilizado de origen no animal (NASHA por gonalgia de origen artrósico provoca una reducción estadísticamente significativa en la intensidad del dolor (escala verbal numérica y WOMAC y de la capacidad funcional (WOMAC en todos los intervalos valorados. Se ha producido una reducción ≥ 30% en la intensidad del dolor en el 54% (valor que coincide con la reducción en la puntuación WOMAC de dolor, en la rigidez en el 62,1% y en la capacidad funcional en el 48,6% de los pacientes. Conclusiones: en nuestros

  17. Computer system to manage information rigs by 3D electronic models; Sistema computacional para administrar la informacion de plataformas petroleras mediante modelos electronicos 3D

    Energy Technology Data Exchange (ETDEWEB)

    Vazquez Bustos, Jesus; Segura Ozuna, Victor Octavio [Instituto de Investigaciones Electricas, Cuernavaca, Morelos (Mexico)

    2012-06-22

    The evolution and incorporation of new hardware technologies, as well as recent advances in computer systems have enabled the development of applications of computer aided design of most complete scope, such as those used for the design of industrial process plants. This article describes a software system developed to complement the capabilities of one of these systems for the design of process plants. A 3D electronic model is generated through the user interface of the design system that at the same time gives the user the ability to generate, publish, review and control the engineering document that are generated during the entire life cycle of a marine oil platform, a very particular type of industrial process plant. This way, the user obtains not only a tool for the design of an industrial plant, but also a system for managing information and engineering documents that are developed. This allows the user to do a more efficient job by putting at his disposal and in the same system, all documents and information required to perform his duty. [Spanish] La evolucion e incorporacion de nuevas tecnologias de hardware, junto con los avances recientes en sistemas de computo ha permitido el desarrollo de aplicaciones de interesante diseno de computo de mayor alcance, tales como los que se emplean en las plantas de procesos industriales. Este articulo describe un sistema de software desarrollado para complementar las capacidades de uno de estos sistemas para el diseno de proceso. Un modelo electronico se genera por medio de la interfaz de usuario del sistema de diseno, que al mismo tiempo da al usuario la capacidad para crear, publicar, revisar y controlar los documentos de ingenieria que se producen durante el ciclo de vida completo de una plataforma marina petrolera, un tipo muy particular de planta de proceso industrial. De este modo, el usuario no solo obtiene una herramienta para el diseno de una planta industrial, sino tambien un sistema para manejar informacion y los documentos de ingenieria que se generan. Lo anterior permite al usuario hacer un trabajo mas eficiente al poner a su disposicion y en el mismo sistema todos los documentos e informacion que requiere para efectuar sus tareas.

  18. Respuesta serológica a la vacunación contra brucelosis en bovinos provenientes de un rebaño libre vacunados con dos dosis de vacuna Cepa RB-51 Serological response to brucellosis vaccination in bovines from a free herd vaccinated with two doses of RB-51

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    C Ramírez

    2009-01-01

    Full Text Available Se realizó una encuesta prospectiva con la finalidad de determinar la respuesta serológica a las pruebas oficiales aplicadas en Chile para la detección de brucelosis bovina que son Rosa de Bengala (RB, Fijación de Complemento (FC y Elisa de Competencia (C-Elisa, en hembras adultas vacunadas con dos dosis de vacuna Cepa RB-51 provenientes de un rebaño libre de la enfermedad con certificación vigente otorgada por el Servicio Agrícola y Ganadero (SAG del Ministerio de Agricultura de Chile. Se seleccionaron 100 hembras bovinas mayores de 18 meses con la finalidad de tener una confianza de un 90% de que la proporción de positivos no será mayor a un 2,95% si todos los animales muestreados resultan negativos. Los bovinos fueron vacunados vía subcutánes con vacuna Cepa RB-51 en dosis de 1-3.4 x 10(10 UFC con una diferencia de 30 días entre la primera y segunda aplicación; la fecha de la primera vacunación correspondió al día cero del estudio. Los días 0, 30 y 60 se tomaron muestras de 10 ml de sangre por venopunción coccígea de cada animal seleccionado. Las muestras se procesaron en el Laboratorio de Referencia de Brucelosis Bovina del SAG, Osorno, X Región, Chile. Ningún animal presentó reacción serológica atribuible a la vacunación con RB-51 que puedan interferir con las pruebas diagnósticas actualmente utilizadas para la detección de la brucelosis bovina.A prospective study was carried out in order to determine the serological response to the official tests used in Chile for the detection of bovine brucellosis which are Rose Bengal (RB, Complement Fixation (CF and Competing Elisa (C-ELISA, in adult cows vaccinated with two doses of vaccine strain RB-51 from a brucellosis free herd as certified by the Servicio Agrícola y Ganadero (SAG of the Ministry of Agriculture of Chile. A total of 100 female bovines older than 18 months were selected in order to be 90% confident that the proportion of positives in cows vaccinated twice

  19. Estudo comparativo entre uma e duas doses efetivas (DE95 de rocurônio para a intubação traqueal Estudio comparativo entre una y de los dosis efectivas (DE95 de rocuronio para la intubación traqueal A comparative study between one and two effective doses (ED95 of rocuronium for tracheal intubation

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    Luciano Carlos Gomes de Miranda

    2008-06-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Os bloqueadores neuromusculares (BNM são fármacos utilizados para produzir relaxamento da musculatura esquelética e facilitar a intubação traqueal (IT. A literatura descreve como sendo necessárias duas doses efetivas (DE95 o ideal para a IT. O rocurônio é um BNM não-despolarizante do tipo esteróide, sintético e de duração intermediária. O objetivo desse estudo foi avaliar e comparar as condições de intubação traqueal (IT, utilizando uma e duas doses efetivas (DE95 do rocurônio, seguindo os critérios da Conferência de Consenso de Copenhague. MÉTODO: Foram avaliados 60 pacientes divididos aleatoriamente em dois grupos de 30, de ambos os sexos, idades entre 20 e 60 anos, estado físico ASA I e II, Mallampati 1 e 2, índice de massa corporal (IMC JUSTIFICATIVA Y OBJETIVOS: Los bloqueadores neuromusculares (BNM son fármacos utilizados para producir el relajamiento de la musculatura esquelética y facilitar la intubación traqueal (IT. La literatura describe que son necesarias de los dosis efectivas (DE95 lo ideal para la IT. El rocuronio es un BNM no despolarizador del tipo esteroide, sintético y de duración intermedia. El objetivo de este estudio fue evaluar y comparar las condiciones de intubación traqueal (IT, utilizando una y de los dosis efectivas (DE95 del rocuronio, secundando los criterios de la Conferencia de Consenso de Copenhague. MÉTODO: Se estudiaron 60 pacientes divididos aleatoriamente en 2 grupos de 30, de ambos sexos, edades entre 20 y 60 años, estado físico ASA I y II, Mallampati 1 y 2, índice de masa corporal (IMC BACKGROUND AND OBJECTIVES: Neuromuscular blockers (NMB are used to induce relaxation of skeletal muscles and facilitate tracheal intubation (TI. According to the literature, two effective doses (ED95 of NMB are ideal for TI. Rocuronium is a steroid-type, synthetic, non-depolarizing neuromuscular blocker of medium duration. The objective of this study was to evaluate

  20. Determinación de la dosis letal media (DL50 de alcaloides del lupino en pollas de reposición blancas y marón Lupine alkaloids in white and brown pullets: determination of mean lethal dose (DL50

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    A. CUBILLOS

    1999-01-01

    Full Text Available Se determinó en pollas de reposición, líneas ISA brown y SHAVER cross, la DL50 tanto de alcaloides totales como de esparteína y lupanina en forma individual, presentes en las semillas de lupinos amargos. Se emplearon 300 pollos por cada línea genética: 100 para los cálculos de las dosis administrando alcaloides totales, 100 para la dosis de esparteína y 100 para lupanina. En la determinación de la DL 50 hubo que calcular la DLmáx y la DLmin, realizándose administraciones de los 3 tipos de productos, con sonda directamente a la ingluvia y observándose las aves por un período de horas post administración. Los resultados de estos estudios establecieron una DL50 de esparteína de 655 (509-856 mg/kg (línea ISAbrown y 425 (303-544 mg/kg (línea SHAVERcross. En el caso de la lupanina la DL50 fue de 1,131 (929-1378 mg/kg (línea ISAbrown y 1,271 (1027-1573mg/kg (línea SHAVERcross. Para los alcaloides totales de la semilla de lupino, se obtuvo una DL50 de 958 (854-1070 mg/kg (línea ISAbrown y 961 (890-1037 mg/kg (línea SHAVERcross. Se concluye que la lupanina fue el alcaloide que presentó los valores de DL50 más altos, seguido por los alcaloides totales y finalmente por la esparteínaDL50 of total alkaloids, as well as of two individual alkaloids (spartein and lupanin found in bitter lupine seeds were determined for ISAbrown and Shavercross pullets. Three hundred chickens were used for each genetic line: 100 to calculate the dosification of the alkaloids administered, 100 for the spartein dossification and 100 for the lupanin dosification. In order to determine the DL50, the maximal and minimal lethal dose had to be determined first. The three types of products were administered with a catheter directly to the crop. After alkaloids were administrated, birds were kept under observation for several hours. The results showed that DL50 for spartein was 655 (509-856 mg/kg for the ISAbrown line and 425 (303-544 mg/kg for the SHAVERcross

  1. Anticoagulación del circuito extracorpóreo esterilizado con óxido de etileno y rayos gamma: ¿necesitan las mismas dosis de heparina? Anticoagulation of the extracorporeal circuit sterilized with ethylene oxide and gamma irradiation: is the same dose of heparin needed?

    Directory of Open Access Journals (Sweden)

    Sonia Muñoz Pilar

    2011-12-01

    Full Text Available Introducción: En los últimos años se han ido sustituyendo las líneas de hemodiálisis esterilizadas con óxido de etileno por las esterilizadas con rayos gamma, dado que numerosos autores han demostrado que es un método más biocompatible. Al utilizar líneas esterilizadas con rayos gamma observamos que se formaban más coágulos que con las esterilizadas con óxido de etileno. Objetivos: Observar si hay diferencia en las dosis de heparina utilizadas y en la formación de coágulos en los circuitos extracorpóreos esterilizados con rayos gamma y óxido de etileno. Material y método: Hemos realizado un estudio cuasi-experimental, longitudinal y prospectivo, utilizando en el mismo paciente líneas de hemodiálisis esterilizadas con rayos gamma y con óxido de etileno. Se realizaron en cada paciente 12 sesiones de hemodiálisis consecutivas con cada tipo de línea. Después de cada sesión se valoraron las pérdidas hemáticas en las cámaras arteriales y venosas, así como las necesidades de heparina. Resultado: Los resultados obtenidos demuestran que la formación de coágulos es mayor en las líneas esterilizadas con rayos gamma y que sí se modificó la dosis de heparina aunque no fue estadísticamente significativa. Discusión: Mantener una buena anticoagulación del circuito extracorpóreo durante la diálisis permite: realizar un tratamiento clínicamente satisfactorio durante el tiempo requerido, evitar pérdidas estimadas altas y minimizar la heparina circulante disminuyendo los efectos secundarios.Introduction: In recent years, haemodialysis lines sterilized using ethylene oxide have been replaced with lines sterilized using gamma irradiation, as several authors have proven that it is a more biocompatible method. On using lines sterilized by gamma irradiation, we observed that more clots were formed than with lines sterilized with ethylene oxide. Aims: To observe whether there is a difference in the heparin doses used and in the

  2. Efecto de la suplementación con una dosis masiva de vitamina A en niños de 6 a 36 meses de edad Effect of massive vitamin A supplement in children from 6 to 36 months of age

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    Alma E. Robles-Sardin

    1998-07-01

    Full Text Available Objetivo. Evaluar el impacto de la suplementación con una dosis masiva de vitamina A en el estado nutricio de dicha vitamina y del hierro, en niños de zonas urbanas marginadas de Hermosillo, Sonora, México. Material y métodos. Se seleccionaron 60 niños (6-36 meses, a los que se les administró una dosis de 100 000 UI (6-12 meses y 200 000 UI (12-36 meses de vitamina A en el Día Nacional de Salud de la Secretaría de Salud (junio de 1994. Se midieron niveles séricos de retinol, carotenoides, hierro, transferrina y ferritina, en tres fases: basal, a las dos semanas y después de tres meses. Resultados. En la primera fase, la mediana de retinol fue 0.7µmol/l; en la segunda aumentó a 0.97µmol/l (p 0.05. Un 6.3% de los niños presentó deficiencia severa de vitamina A al inicio, y no se encontró ningún caso en las fases posteriores a la suplementación. En la fase basal, 42% de los casos presentaron deficiencia moderada y la mayoría fue normal en las siguientes fases. No hubo diferencias en los niveles de hierro y transferrina (p > 0.05, pero sí en ferritina (p Objective. To evaluate the impact of a single massive dose of vitamin A on the vitamin and iron status in children of margined urban areas in Hermosillo, Sonora, Mexico. Material and methods. A total of 60 children received one dose of 100 000 IU (children from 6 to 12 months and of 200 000 IU (children from 12 to 36 months of retinol palmitate distributed by the Health Ministry in June, 1994. Serum levels of retinol, carotenoids, iron, transferrin and ferritin were measured at three periods: basal, after two weeks and after three months. Results. The mean for retinol basal values was 0.7 µmol/l, after two weeks it was 0.97 µmol/l (p 0.05. When basal values were measured, 6.3% of the children showed severe vitamin A deficiency, which disappeared in the periods following the supplement; additionally, 42% showed moderate deficiency which had decreased to less than 7% after three

  3. Use of different doses of Hidrogel for sweet pepper seedling production El uso de diferentes dosis de hidrogel para para la producción de plántulas de pimiento Uso de diferentes doses de hidrogel para produção de mudas de pimentão

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    Rhona Ortenzi Bastos

    2010-05-01

    substrato Bioterra, sendo: 0; 1,0; 1,5 e 2,0 g kg-1 de substrato. O ensaio foi conduzido durante o período de março a abril de 2007, em viveiro telado da Universidade do Oeste Paulista (Unoeste, Presidente Prudente – SP. Utilizou-se pimentão variedade Cascadura Ikeda. As variáveis avaliadas foram altura da planta; comprimento da raiz; número de folhas; massa seca da parte aérea e da parte radicular. O uso do hidrogel não promoveu diferenças no sistema radicular da muda de pimentão. Não houve efeito do hidrogel no comprimento da parte aérea, mas o hidrogel interferiu na massa seca da parte aérea, pois quando se aumentou a dose do hidrogel se observou como resposta o desenvolvimento de folhas e não o crescimento em altura promovendo um ajuste linear positivo significativo da massa seca da parte aérea com aumento da dose de hidrogel proporcionando uma muda de melhor qualidade.

    El pimiento (Capsicum annuum es una hortaliza de gran importancia socioeconómica en Brasil. Una de las principales etapas del sistema de producción es la producción de plántulas de calidad, y esto requiere de un sustrato con buena porosidad y retención de água. La técnica de adición de hidrogel como acondicionador del suelo tiene como objetivo aumentar la capacidad de retener agua en sustratos para plántulas. El objetivo de este estudio fue analizar el desarrollo de las plántulas de pimiento con el uso de cuatro dosis del hidrogel hydroplan-EB añadido al sustrato Bioterra, siendo: 0, 1,0, 1,5 y 2,0 g kg-1 de sustrato. El ensayo ha sido desarrollado entre marzo y abril de 2007 en vivero cerrado con tela en la Universidad de Oeste Paulista (UNOESTE, Presidente Prudente - SP. Se utilizó el pimiento variedad Cascadura Ikeda. Las variables evaluadas fueron altura de planta, longitud de la raíz, número de hojas, masa seca de lo dosel vegetativo y parte de la raíz. El uso de hidrogel no he causado diferencias en el sistema

  4. Efeitos hemodinâmicos e renais da injeção de doses elevadas de clonidina no espaço peridural do cão Efectos hemodinámicos y renales de la inyección de dosis elevadas de clonidina en el espacio peridural del perro Hemodynamic and renal effects of high epidural clonidine doses in dogs

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    Nilson Camargo Roso

    2005-06-01

    ébito cardíaco e aumento da relação depuração de para-aminohipurato de sódio/débito cardíaco. CONCLUSÕES: Nas condições realizadas e nas doses empregadas, pode-se concluir que a clonidina não promoveu alteração da função renal, mas diminuiu valores hemodinâmicos (freqüência e débito cardíaco.JUSTIFICATIVA Y OBJETIVOS: No existen estudios que relaten las repercusiones renales determinadas por la inyección de dosis elevadas de clonidina en el espacio peridural. La finalidad del estudio fue evaluar los efectos hemodinámicos y renales determinados por la inyección de dosis elevadas de clonidina en el espacio peridural del perro. MÉTODO: Veinte animales anestesiados con tiopental sódico y fentanil fueron distribuidos eventualmente y de forma doblemente encubierta en dos grupos: Grupo 1 ó placebo (n = 10, que recibió 0,2 mL.kg-1 de solución fisiológica, y Grupo 2 ó clonidina (n = 10, que recibió 0,2 mL.kg-1 de una solución conteniendo 50 µg.mL-1 de clonidina, en el espacio peridural. Fueron evaluados los siguientes parámetros hemodinámicos: frecuencia cardiaca (FC: lat.min-1; presión arterial media (PAM: mmHg; presión de la arteria pulmonar ocluida (PAOP: mmHg; débito cardíaco (DC: L.min-1; volumen sistólico (VS: mL; también, los siguientes parámetros de la función renal fueron evaluados: flujo sanguíneo renal (FSR: mL.min-1; resistencia vascular renal (RVR: mmHg.mL-1.min; volumen urinario minuto (VUM: mL.min-1; depuración de creatinina (DCr: mL.min-1; depuración de para-aminohipurato (DPAH: mL.min-1; fracción de filtración (FF; depuración de sodio (DNa: mL.min-1; depuración de potasio (DK: mL.min-1; excreción fraccionaria de sodio (EFNa: %; excreción urinaria de sodio (UNaV: µEq.min-1; excreción urinaria de potasio (UKV: µEq.min-1. El experimento consistió en tres momentos de 20 minutos cada uno. Los datos fueron colectados a los 10 minutos de cada momento y la diuresis, en el inicio y al final de cada momento. Al t

  5. Efecto de diferentes dosis de gonadotrofina coriónica equina sobre la respuesta reproductiva de hembras ovinas con un tratamiento para inducción de celos Effect of different doses of equine chorionic gonadotropin on reproductive performance in sheep with oestrus induction treatment cycle

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    R Catalano

    2007-12-01

    Full Text Available El objetivo de este trabajo fue comparar el efecto de diferentes dosis de eCG en un tratamiento para inducción de celos en borregas (Ensayo 1 y ovejas (Ensayo 2 (Frisona x Corriedale en anestro estacional sobre variables reproductivas. Se utilizaron esponjas intravaginales con 60 mg de acetato de medroxiprogesterona por 10 días y al retiro de las mismas se administraron 300 UI (grupo G300 ó 500 UI (grupo G500 de eCG. El porcentaje de celo no fue diferente entre grupos (Ensayo 1 = 100%; Ensayo 2 = 81,2%. En el Ensayo 1 se observó una tendencia a diferir en el porcentaje de borregas que ovularon (G300 = 50,0%; G500= 90,0%. P=0,06 y una diferencia significativa en el porcentaje de preñez (G300 = 20,0%; G500 = 70,0%. PThe aim of this study was to evaluate the reproductive performance of seasonally anoestrus hoggets (Trial 1 and ewes (Trial 2 (Frisona x Corriedale treated with intravaginal sponges containing 60 mg of medroxiprogesterone acetate during 10 days and different doses of eCG. At the end of treatment, 300 IU of eCG (group G300 or 500 IU of eCG (group G500 were injected intramuscularly. Oestrus rate was not different between groups (Trial 1= 100%; Trial 2= 81.2%; P>0.05. In the trial 1, the percentage of hoggets that ovulated tended to differ between groups (G300= 50.0%; G500= 90.0%; P=0.06 and the pregnancy rate was signifi cant different (G300= 20.0%; G500= 70.0%; P<0.05. In the trial 2, the pregnancy and the fertility rates were signifi cant different between groups G300 and G500 (6.3 and 9.1 vs 56.3 and 60.0% respectively; P<0.05. It was concluded that the use of 300 UI of eCG in a treatment of oestrus induction of seasonally anoestrus hoggets and ewes affect negatively the reproductive performance compared with the use of 500 UI of eCG.

  6. Braquiterapia endobronquial de alta tasa de dosis en pacientes con obstrucción de la vía aérea central: Experiencia en el Instituto Nacional del Cáncer y revisión de la literatura High dose rate endobronchial brachytherapy in patients with central airway obstruction

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    ALEJANDRO SANTINI B

    2010-09-01

    Full Text Available Introducción: La indicación principal de la braquiterapia endobronquial moderna (BTEB de alta tasa de dosis (HDR, es la paliación de síntomas por crecimiento endobronquial de cánceres pulmonares. Métodos: Se realizó BTEB HDR a 27 pacientes sintomáticos de patología tumoral endobronquial o traqueal, debido a patologías primarias bronquiales o secundarias metastásicas. Los tumores se ubicaban en tráquea, carina o a nivel bronquialproximal. Para observar mejorías en la sintomatología clínica, a todos se les realizó una fibrobroncoscopía (FBC para medir el grado de obstrucción bronquial e instalar catéteres endobronquiales de braquiterapia. Se administraron entre 1 y 4 fracciones de 7 a 7,5 Gy. Se registró subjetivamente la disnea, tos y hemoptisis antes y después del tratamiento, de acuerdo a una escala internacionalmente validada. Resultados: Tras el tratamiento todos los síntomas disminuyeron considerablemente, desapareciendo toda sintomatología severa. La hemoptisis y disnea desaparecieron en el 100% y 40% de los pacientes respectivamente, y la tos desapareció o disminuyó a grado leve en el 90% de los pacientes.Introduction: The main indication of modern high dose rate end bronchial brachyherapy (HDR EBBT is the palliation of symptoms related to the growth of the endobronchial lung cancer. Methods: EBBT was performed to 27 patients who suffered symptomatic tumoral endobronchial or tracheal pathology, due to primary bronchial disease or secondary metastasis cancer, evaluating the rate of clinical benefit. The tumors were located at tracheal, carinal or proximal bronchial level. Fibrobronchoscopy was performed to all the patients to measure the degree of airway obstruction and to install brachytherapy endobronchial catheters. Between 1 to 4 fractions of 7 to 7.5 Gy were administered. Dyspnea, cough and hemoptysis were subjectively registered before and after treatment, according to an international validated scale. Results

  7. Patient Safety in Drug Therapy and the Influence of the Prescription in Dose Errors Seguridad del paciente en la terapéutica medicamentosa y la influencia de la prescripción médica en los errores de dosis Segurança do paciente na terapêutica medicamentosa e a influência da prescrição médica nos erros de dose

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    Fernanda Raphael Escobar Gimenes

    2010-12-01

    Full Text Available The aims of this study were to analyze the redaction of the prescription in dose errors that occurred in general medical units of five Brazilian hospitals and to identify the pharmacological classes involved in these errors. This was a descriptive study that used secondary data obtained from a multicenter study conducted in 2005. The population consisted of 1,425 medication errors and the sample of 215 dose errors. Of these, 44.2% occurred in hospital E. The presence of acronyms and/or abbreviations was verified in 96.3% of prescriptions; absence of the patient registration in 54.4%; absence of posology in 18.1%; and omission of date of 0.9%. With respect to medication type, 16.8% were bronchodilators; 16.3% were analgesics; 12.1%, antihypertensives; and 8.4% were antibiotics. The absence of posology in the prescriptions may facilitate the administration of the wrong dose, resulting in inefficiency of the treatment, compromising the quality of care provided to hospitalized patients.Los objetivos fueron analizar la redacción de la prescripción médica en los errores de dosis ocurridos en unidades de clínica médica de cinco hospitales brasileños e identificar las clases farmacológicas envueltas en esos errores. Se trata de estudio descriptivo que utilizó datos secundarios obtenidos de en una investigación multicéntrica realizada en 2005. La población fue compuesta de 1.425 errores de medicación y la muestra por 215 errores de dosis. De estos, 44,2% ocurrieron en el hospital E. Se verificó: presencia de siglas y/o abreviaturas en 96,3% de las prescripciones; ausencia del registro del paciente en 54,4%; falta de posología en 18,1%, y omisión de la fecha en 0,9%. Con relación al tipo de medicamento, 16,8% eran broncodilatadores; 16,3% eran analgésicos; 12,1%, antihipertensivos y 8,4% eran antimicrobianos. La ausencia de la posología en las prescripciones puede favorecer la administración de dosis equivocadas, resultando en

  8. Dosis óptima económica de nitrógeno en maíz según potencial de producción y disponibilidad de nitrógeno en la región pampeana norte Economic optimal nitrogen rate as affected by yield potential and nitrogen supply in the northern pampas

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    Fernando Salvagiotti

    2011-12-01

    Full Text Available El maíz es el principal cereal de verano en la Región Pampeana norte de la Argentina donde los suelos presentan una deficiencia crónica de nitrógeno (N. La fertilización nitrogenada en maíz debe optimizar los niveles de N disponible a la siembra (Nds=Nds inic + N fertilizante para asegurar la máxima rentabilidad y evitar altas dosis que perjudiquen el ambiente. Los objetivos de este trabajo fueron: i comparar la capacidad de los modelos cuadrático-plateau (CP y esférico (Esf para estimar la respuesta a la fertilización con N; ii determinar umbrales críticos de Nds (UCNds en cultivos de alto (AR y bajo (BR rendimiento, y iii calcular en estas situaciones la dosis óptima económica de N (DOE y la eficiencia en el uso del N en la DOE (EA DOE con distinto Nds. Se analizaron 39 experimentos de fertilización nitrogenada (sitio-año-SA, los modelos CP y Esf ajustaron con precisión la relación entre rendimiento y Nds en toda la red, pero el modelo CP presentó dificultades para representar la forma asintótica de la curva de respuesta en algunos SA en particular. Los UCNds fueron de 137 y 161 kg N ha-1 en BR y AR. Utilizando una relación de precios maíz: N de 10:1, la DOE fue de 99 y 78 kg N ha-1 y la EA DOE de 28 y 17 kg grano kg N-1 para AR cuando Nds inic fue 40 y 80 kg N ha-1. En cambio para BR, para las mismas Ndsinic, la DOE fue de 71 y 49 kg N ha-1 con una EADOE de 15 y 8 kg grano kg N-1. Al cambiar la relación de precios a situaciones más desfavorables, la DOE y la EA DOE disminuyeron, pero con mayor magnitud en BR. Los resultados de este trabajo remarcan que, para un correcto diagnóstico de la fertilización nitrogenada en maíz, es importante definir el potencial de rendimiento del cultivo que permitirá alcanzar mayor rentabilidad haciendo un uso eficiente del fertilizante.Maize is the most important summer cereal in the Northern Pampas of Argentina where soils present severe nitrogen (N deficiency. N fertilization in

  9. Dose in conventional radiography; Dosis en radiografia convencional

    Energy Technology Data Exchange (ETDEWEB)

    Acuna D, E.; Padilla R, Z. P.; Escareno J, E.; Vega C, H. R. [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Calle Cipres No. 10, Fracc. La Penuela, 98000 Zacatecas (Mexico)

    2011-10-15

    It has been pointed out that medical exposures are the most significant sources of exposure to ionizing radiation for the general population. Inside the medical exposures the most important is the X-ray use for diagnosis, which is by far the largest contribution to the average dose received by the population. From all studies performed in radiology the chest radiography is the most abundant. In an X-ray machine, voltage and current are combined to obtain a good image and a reduce dose, however due to the workload in a radiology service individual dose is not monitored. In order to evaluate the dose due to chest radiography in this work a plate phantom was built according to the ISO recommendations using methylmethacrylate walls and water. The phantom was used in the Imaging department of the Zacatecas General Hospital as a radiology patient asking for a chest study; using thermoluminescent dosimeters, TLD 100 the kerma at the surface entrance was determined. (Author)

  10. HASIL GUNA IMUNISASI DASAR DIFTERI DENGAN VAKSIN DPT 2 DOSIS

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    Dyah W. Isbagio

    2012-09-01

    Full Text Available A retrospective study on a basic diptheria immunization was done in Tulangan district of East Jawa, involving three hundred ninety two children with various immune status, that say 0,1 and 2 doses of DPT vaccine manufactured by Perum. Bio Farma, Bandung. The study was aimed to measure serological effectiviness 2 of doses of DPT vaccine for inducing immunity against diphtheria in real life situation. Diphtheria antitoxin titre was examined by Passive Haemagglutination Assay on 0,1 ml of capillary blood specimens. The result showed that 2 doses of DPT vaccine given at 1-3 months interval on children of 3—14 months old, were able to induce an adequate immune response on more than 80% of the children. Immune response with 0 and 1 doses of DPT vaccine has also been discussed. The potensial implication of this study result, supported by other study on a various of age, on the administration strategy of booster dose of Td ("adult type" vaccine among school children has also been suggested.

  11. Dosis Aman Adrenalin dalam Larutan Anestesi Lokal untuk Penderita Hipertensi

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    Untary Untary

    2015-08-01

    Full Text Available The treatment of patients with hypertension is increasingly common. Hypertensives are a problem because they exhibit a great lability of a blood pressure. The anticipation of dental treatment causes an initial elevation of the blood pressure which may be heightened by the stimulus of an injection or dental treatment. However, probably the underlying causes is endogenous adrenaline. Adrenaline is the most potent and efficient of vasoconstricting drug used in dental anesthetic solution. Lidocaine causes vasodilation, without adrenaline lidocaine is rapidly absorbed from the administration site. Vasoconstrictors are important additions to local anesthetic solutions. They improve the quality of pain control and its duration while decreasing the potential toxicity of the local anesthetic. Observation of dental clinic patients at Loma Linda University confirm the fact that the blood pressure is not elevated by the small amount of vasocontrictor (1:100,000 contained in the most commonly employed dental anesthetic solution. All of the adrenergic amines can produce potentially dangerous cardiovascular effect and elicit disturbing subjactive response when high blood concentration are obtrained. For these reasons Felypressin a nonsymphatomimetic amine alternative for vasoconstriction has been used. An aspirating syringe should be used to avoid the risk of intra vascular injection when administering a local anesthetic solution and it is considered advisable to avoid adrenaline if the hypertension is not controlled.

  12. Drift of sub-doses of glyphosate in young plants of Varjão (Parkia multijuga, Benth. Deriva de sub-dosis de glyphosate en plantas jóvenes de Varjão (Parkia multijuga Benth. Deriva de sub-doses de glyphosate em plantas jovens de Varjão (Parkia multijuga Benth.

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    Oscar Mitsuo Yamashita

    2011-09-01

    Full Text Available

    Este estudio tuvo como objetivo evaluar la respuesta a la toxicidad de diferentes sub-dosis de glyphosate en las plantas jóvenes de Varjão (Parkia multijuga Benth.. El experimento se ha instalado en área experimental de la UNEMAT - Universidad de lo Estado de Mato Grosso, en el Campus de Alta Floresta, Alta Floresta-MT. Los tratamientos fueron tres sub-dosis de glifosato (T1-6%, T2-12%, T3-24% de la dosis recomendada de 3,0 L ha-1 y T4 - control (sin aplicación. Después de 7, 14, 21, y 28 días y de 6 meses de aplicación del herbicida, se hicieron mediciones de la altura y de lo diámetro de las plantas con la atribución de las notas de fitotoxicidad. Después de 6 meses de aplicación del herbicida, se encontró que dosis crecientes de glyphosate provocan lesiones en las hojas y reducción del crecimiento en altura de las plantas de Parkia multijuga, hubo uno pequeño índice de mortalidad, sin embargo, se observó una mejoría significativa en todos los tratamientos probados.

    This work aimed to evaluate the response to toxicity of different sub-doses of glyphosate in young plants of varjão (Parkia multijuga, Benth.. The experiment was installed in the experimental area of UNEMAT – State University of Mato Grosso, in Alta Floresta – Mato Grosso state. The treatments tested were three sublethal rates of glyphosate (T1-6%, T2-12%, T3-24% of the recommended dose of 3.0 L ha-1 and T4-control (without application. After 7, 14, 21, 28 days and 6 months of the application of the herbicide, it was performed measurements of the height and diameter of the cervix of plants and given the notes of phytotoxicity. After 6 months of the application of the herbicide, it was found that the increasing doses of glyphosate caused injuries in the leaves and reduction of growth in height in plants of Parkia multijuga, there was low index of mortality

  13. Dosis efectiva de hidromorfona en pacientes con dolor crónico oncológico: experiencia de 4 años en el Centro Médico Nacional "20 de Noviembre" ISSSTE Effective dose of hydromorphone in patients with chronic oncologic pain: a four-year experience in the Centro Médico Nacional 20 de Noviembre, a public hospital in Mexico

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    E. Rionda

    2009-07-01

    Full Text Available Antecedentes: Aproximadamente 6,35 millones de nuevos casos de cáncer se diagnostican anualmente. El 90% de los pacientes con cáncer avanzado presentan dolor. El objetivo en el tratamiento del dolor oncológico es aliviar el dolor, interrumpiendo la transmisión o modulándolo a nivel cerebral o espinal. La Organización Mundial de la Salud (OMS desarrolló una escala de tres escalones para manejar el dolor oncológico. En el escalón I se incluyen analgésicos no opiáceos + coadyuvantes; en el escalón II se incluyen opiáceos leves + coadyuvantes y en el escalón III se incluyen opiáceos potentes + coadyuvantes. Material y métodos: Se revisaron 72 expedientes, en un total de 4 años, de todos los pacientes con dolor crónico oncológico que hayan estado en tratamiento con hidromorfona. En este trabajo obtuvimos la dosis promedio en la que se logró un buen control del dolor (escala analógica visual [EVA] Background: Approximately 6.35 million patients are diagnosed with cancer annually. Around 90% of patients with advanced cancer have pain. Treatment of oncologic pain aims to relieve pain by modulating or interrupting transmission in the spine or brain. The World Health Organization (WHO has developed a three-step ladder for cancer pain management. At step I, non-opioid plus adjuvant drugs are included. Step II includes opioids for mild to moderate pain plus adjuvants, and step III includes opioids for moderate to severe pain plus adjuvants. Material and methods: We reviewed 72 files corresponding to all the patients with chronic cancer pain that had been treated with hydromorphone during the previous 4 years in our hospital and calculated the mean dose at which the patients reported good pain control (Visual Analog Scale [VAS] < 4. We also studied the most common adverse effects, and whether any of the patients discontinued the treatment, and if so, the reasons for discontinuance. The type of cancer in each patient and the length

  14. Calidad de imagen y dosis de radiación de la angiografía coronaria por tomografía computada multidetector con técnica de adquisición axial con gatillado prospectivo Imaging quality and effective radiation dose of prospective ECG-gated axial multidetector row computed tomography coronary angiography Objective

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    Carlos Capuñay

    2011-09-01

    Full Text Available Objetivo. Determinar la calidad de imagen y la dosis de radiación efectiva (DRE de la angiografía coronaria por tomografía computada con adquisición con gatillado prospectivo (ACTC-P en comparación con la técnica de adquisición con gatillado retrospectivo (ACTC-R. Materiales y Métodos. Cuarenta y cinco estudios de ACTC-P fueron analizados en forma retrospectiva para la valoración de la calidad de imagen y DRE, y se compararon con 90 estudios de ACTC-R realizados sin (n = 45 y con (n = 45 modulación de la corriente del tubo de rayos X seleccionados de la base de datos acorde a características demográficas similares. La DRE se comparó entre los tres grupos. La calidad de imagen fue analizada en forma independiente por dos observadores y comparada con el grupo de ACTC-R modulada. Se determinó también la variabilidad interobservador. Resultados. No hubo diferencias significativas en la calidad de imagen entre los dos grupos. La variabilidad interobservador fue k=0,92 (IC 95%: 0,87 a 0,96. La DRE (media ± DS de la ACTC-P fue 2,88 ± 0,37 mSv comparado con 10,50 ± 1,15 mSv (p To determine the imaging quality and effective radiation dose (ERD of prospective ECG-gated multidetector row computed tomography coronary angiography (PMDCT-CA compared to retrospective ECG-gating (RMDCT-CA. Materials and Methods. Forty-five PMDCT-CA scans were retrospectively reviewed for assessing imaging quality and ERD, and compared to 90 RMDCT-CA scans performed with (n= 45 and without (n= 45 tube current modulation, selected from our database on the basis of similar demographical characteristics. ERD was compared between all three groups. Imaging quality was assessed by two independent observers and compared to the imaging quality of the group of RMDCT-CA scans performed with tube current modulation. The interobserver variability was also determined. Results. There were no significant differences in imaging quality between the two groups. Interobserver

  15. Vivax malaria in children: recurrences with standard total dose of primaquine administered in 3 vs. 7 days Malaria vivax en niños: recurrencias con dosis total estándar de primaquina administrada durante 3 frente a 7 días

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    Jaime Carmona-Fonseca

    2010-02-01

    ="line-height: 200%; font-family: ">Objetivo: evaluar la eficacia de dos dosificaciones de primaquina en menores de 18 años.

    Materiales y métodos: estudio clínico controlado, no enmascarado, con asignación aleatoria del tratamiento. Se evaluaron dos grupos según la dosis de primaquina: 0,50 mg/kg/día por 7 días (0,50-7 frente a 1,17 mg/kg/día por 3 días (1,17-3.

    Resultados: A. Curación del ataque agudo: eficacia del 100% en los dos grupos; B. Prevención de las recurrencias durante 120 días: ocurrieron recurrencias en 68,4% de los niños tratados con el esquema 1,17-3, y en 34,2% de los que recibieron el régimen 0,50-7.

    Conclusiones: 1. La proporción de recurrencias a los 120 días en niños tratados con el esquema 0,50-7 (34,2% fue significativamente menor que la de los niños que recibieron el régimen 1,17-3 (68,4%. 2. El tiempo de administración de una misma dosis total de primaquina influye en su eficacia contra las recurrencias: a menos días, menor eficacia.

     

  16. Farmacogenomica della Clofarabina nel trattamento delle Leucemie Acute pediatriche: identificazione di nuovi bersagli molecolari e del profilo genomico associato all’efficacia terapeutica del farmaco antitumorale

    OpenAIRE

    Formica, Serena

    2012-01-01

    In quest’ultimi decenni si è assistito ad un notevole miglioramento nella terapia delle Leucemie Acute (LA) pediatriche, nonostante tutto si assiste oggi ad una fase di plateau della curva di sopravvivenza e le leucemie continuano a costituire la principale causa di morte pediatrica per malattia. Ulteriori progressi nel trattamento delle LA potrebbero essere ottenuti mediante studi di farmacogenomica che, identificando le componenti genetiche associate alla risposta individuale ai trattamenti...

  17. Dosimetric comparison in a cancer of the Cervix with different therapeutic modalities; Comparacion dosimetrica en un cancer de Cervix con distintas modalidades terapeuticas

    Energy Technology Data Exchange (ETDEWEB)

    Alonso Iracheta, L.; Casa de Julian, M. A. de la; Samper Ots, P.; Penas Cabrera, M. D. de las; Jimenez Gonzalez, J. M.

    2013-07-01

    Cervical cancer is usually treated with radiotherapy composed of 3D (RC3D) and supine position, and is usually not usually outline the small intestine in cases of exclusively pelvic irradiation. In our Center we wanted to check what dose receives the small intestine in these cases and if the positioning of the patient or used irradiation technique influence the distribution of the histogram dose-volume. (Author)

  18. Seguimiento de dependientes del alcohol y/o de la cocaina despues de su salida de una Comunidad Terapeutica: estudio piloto

    OpenAIRE

    López-Fernández, Olatz; Ferrer Pérez, Xavier; Lafarga-Lebey, S.; Honrubia Serrano, Ma. Luisa; Tudela-Marí, M.

    2011-01-01

    Introducción Los avances en farmacoterapia del alcoholismo podrían propiciar un cambio de paradigma, basado en los nuevos programas de reducción del consumo de alcohol. Material y Método Este estudio revisa los fundamentos neurobiológicos y farmacoterapéuticos del alcoholismo, centrándose en los antagonistas opioides, el tratamiento orientado a la abstinencia y el orientado hacia la reducción del consumo de alcohol. Resultados 1. Los programas de tratamiento de la dependencia del alcohol pres...

  19. Optimization of the therapeutic dose of {sup 131}I for thyroid differentiated carcinoma; Otimizacao da dose terapeutica com {sup 131}I para carcinoma diferenciado da tiroide

    Energy Technology Data Exchange (ETDEWEB)

    Lima, Fabiana Farias de

    2002-09-01

    I-131 thyroid cancer therapy is based on the strategy of concentrating radioactive iodine in the thyroid tissue, to completetly eliminate thyroid tissue and functioning thyroid cancer metastases remaining after thyroidectomy. In Brazil, fixed activities of {sup 131} I generally are given, sometimes either delivering insufficient activities to ablate all of the remnants, or unnecessarily high activities, with patients remaining in the hospital for some period of time. This investigation proposes a protocol of individualized planning of ablative doses, based on individual patients metabolisms and measured thyroid remnant masses. Simulated thyroid remnants were fabricated in various forms, volumes and activities, and optimum image acquisition parameters were determined using Single-Photon Emission Computed Tomography 9SPECT). Resultant images were evaluated, to determine the apparent volumes and the {sup 131} I concentrations. I-131 metabolism was studied in 9 patients who had undergone thyroidectomies. Their thyroid remnant masses were determined applying the same parameters used in SPECT simulation studies, and the optimum activity for their therapy was calculated and compared to the established fixed activity of 3.7 GBq (100 mCi), which would have normally been assigned. Background subtraction using the method of percent maximum counts, using a value of 67.5%, combined with scatter correction (triple energy window method), was shown to be optimum for SPECT quantification of volumes between 3-10 ml. Errors in the method were below 9% for sources with regular geometries and around 11% for sources with irregular geometries. In the patient studies, it was observed that 78% of patients could have received reduced activities of {sup 131} (from 0.8-3-2. GBq (20-87 nCi). In addition, 33% of these patients could have received low enough activities to have discharged from the hospital, using an individualized administration scheme. This could also have resulted in a dose reduction for many organs, such as the narrow and gonads, of up to 78.4%.Possible benefits to the institution also include the use of less radioactive material and a reduction in radiation exposures to the staff during the manipulation and administration of the {sup 131} I. To facilitate the calculations of the optimum therapeutic activity of {sup 131} I for individual patients, a simple and fast dose planning program was created (PlanDose). The program has been set up to evaluate thryroid remant ablation, but it can also be used for the calculation of the activity to be administered for treatment of hyperthyroidism. This protocol of calculated optimal patient-specific {sup 131} I. activities allows a better determination of the necessary ablative dose for patients with differentiated carcinoma of the thyroid, and is an example of optimizing the practice of radiation protection. (author)

  20. Efecto de diferentes dosis de fertilización inorgánica con N, P, K y fuente orgánica (estiércol de broiler sobre la producción de maíz y la fertilidad del suelo Effect of different doses of N, P, K inorganic fertilization and organic source (poultry litter on maize production and soil fertility

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    Juan Hirzel

    2004-10-01

    Full Text Available La disponibilidad de cama de broiler (CB, mezcla de estiércol de broiler sobre viruta, ha aumentado sostenidamente debido a la mayor producción de carne de ave. El uso de este producto como fertilizante disminuye la contaminación desde zonas de acumulación y a la vez mejora la fertilidad de los suelos. En este estudio se comparó el nivel de macronutrientes, pH, materia orgánica (MO y conductividad eléctrica (CE del suelo y la producción de MS de maíz (Zea mayz L., para ensilaje obtenidos con la aplicación de dos fuentes de N:P2O5:K2O: CB y fertilizantes inorgánicos, (urea, superfosfato triple (SFT y muriato de potasio (KCl, en suelos de origen volcánico de la VII y VIII Región de Chile, correspondientes a un Vitrandepts y Typic Melanoxerands, respectivamente. En ambas fuentes de N:P2O5:K2O, las dosis evaluadas correspondieron a 192:150:141 y 384:300:282 kg ha-1. Adicionalmente se evaluaron los contenidos de macronutrientes en las plantas de maíz para ensilaje a la cosecha. Las evaluaciones de fertilidad química del suelo se realizaron en las estratas de 0-20 cm en el suelo Vitrandepts, y 0-20 y 20-40 cm en el suelo Typic Melanoxerands. Los resultados obtenidos, posteriores a la cosecha, indicaron que en el suelo Vitrandepts la producción de MS y el nivel de P Olsen fueron mejorados con la aplicación de CB, en tanto que el nivel de Mg intercambiable disminuyó con la dosis más alta de urea. En el suelo Typic Melanoxerands no se obtuvieron diferencias concluyentes para los parámetros evaluados, aunque se observó un aumento en el nivel de P Olsen.The availability of broiler manure (CB, a mix of broiler litter and wood shavings, has steadily increased as result of the higher poultry production. The use of broiler manure as a soil fertilizer decreases contamination of storage area, and at the same time improves soil fertility. In this study macronutrients, pH, organic matter (OM and electrical conductivity (EC of soil and corn

  1. Efectividad, tolerabilidad y calidad de vida en el tratamiento del dolor crónico no oncológico, con tramadol de liberación controlada en dosis única diaria Effectiveness, tolerability and quality of life in the management of chronic pain unrelated to cancer with sustained-release tramadol administered in a single daily dose

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    M Casals

    2004-04-01

    Full Text Available Objetivo: Evaluar la efectividad y tolerabilidad del tratamiento del dolor crónico no oncológico, con tramadol de liberación controlada y prolongada en dosis única diaria. Material y métodos: Estudio prospectivo, observacional, multicéntrico de farmacoepidemiología. En él participaron un total de 100 Unidades de Dolor de nuestro país. Se incluyeron pacientes con dolor crónico no oncológico que iniciaron tratamiento con tramadol de liberación controlada y prolongada. Para evaluar la efectividad del fármaco se registraron las características antropométricas, el tipo de dolor, su intensidad y su repercusión sobre el sueño y la calidad de vida. Se realizaron dos seguimientos: uno a la semana y otro al mes del inicio del tratamiento registrándose las variaciones en los indicadores de dolor: escala analógica visual y test de Lattinen, calidad de vida, la aparición de reacciones adversas y los cambios en el tratamiento. Resultados: Se estudiaron 907 pacientes, 66,03% mujeres y 33,97% hombres. El 52,92% de pacientes sufrían lumbalgia y el 33,96% osteoartritis. Se observó un descenso significativo en todos los indicadores de dolor desde la primera semana de tratamiento. La incidencia de efectos secundarios fue de un 16,8%, con una duración media de 6,3 ± 4 días. Las náuseas y los vómitos fueron la reacción adversa con mayor incidencia (18,3%, seguida del estreñimiento y somnolencia (10,5% y 10,3% respectivamente. El mayor impacto de la respuesta analgésica de tramadol de liberación controlada y prolongada se reflejó en el índice del estado físico de la calidad de vida. El 93,22% de los pacientes cumplimentaron adecuadamente el tratamiento y el 66,38% se declararon satisfechos o muy satisfechos con el tratamiento al finalizar el estudio. Conclusiones: Tramadol de liberación controlada y prolongada se mostró altamente efectivo en la reducción del dolor desde la primera semana de tratamiento. La tolerabilidad fue buena

  2. Raquianestesia unilateral com baixa dose de bupivacaína a 0,5% hiperbárica Raquianestesia unilateral con baja dosis de bupivacaína a 0,5% hiperbárica Unilateral spinal anesthesia with low 0.5% hyperbaric bupivacaine dose

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    Luiz Eduardo Imbelloni

    2004-10-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A raquianestesia unilateral pode apresentar vantagens, principalmente em pacientes ambulatoriais. Baixas doses da solução anestésica, agulhas ponta de lápis ou ponta cortante, lenta velocidade de injeção e a posição lateral têm sido relatados como facilitadores da produção de raquianestesia unilateral. O presente estudo longitudinal investiga o grau de raquianestesia unilateral utilizando 5 mg de bupivacaína a 0,5% hiperbárica injetada através de agulha 27G tipo Quincke no paciente em decúbito lateral, com membro a ser operado voltado para baixo. MÉTODO: Raquianestesia com bupivacaína a 0,5% foi realizada através da agulha 27G Quincke em 30 pacientes estado físico ASA I e II, submetidos à cirurgias ortopédicas. A punção subaracnóidea foi realizada com o paciente previamente colocado com o lado a ser operado voltado para baixo e foram injetados 5 mg de bupivacaína a 0,5% hiperbárica na velocidade de 1 ml.15s-1. Bloqueios sensitivo e motor (picada de agulha e escala de 0 a 3 foram comparados entre os lados a ser operado e o contralateral. RESULTADOS: Os bloqueios motor e sensitivo entre o lado operado e o contralateral foram significativamente diferentes em todos os momentos. Raquianestesia unilateral foi obtida em 85,7% dos pacientes. Estabilidade hemodinâmica foi observada em todos os pacientes. Nenhum paciente desenvolveu cefaléia pós-raquianestesia. CONCLUSÕES: Nas condições deste estudo a bupivacaína hiperbárica a 0,5% (5 mg proporcionou um predominante bloqueio unilateral. Vinte minutos foram suficientes para a instalação do bloqueio. As principais vantagens da raquianestesia unilateral são a estabilidade hemodinâmica, a satisfação do paciente e recuperação mais rápida da anestesia.JUSTIFICATIVA Y OBJETIVOS: La raquianestesia unilateral pode presentar ventajas, principalmente en pacientes ambulatoriales. Bajas dosis de la solución anestésica, agujas punta de lápiz o

  3. Baixas doses de bupivacaína a 0,5% isobárica para raquianestesia unilateral Bajas dosis de bupivacaína a 0,5% isobárica para raquianestesia unilateral Low isobaric 0.5% bupivacaine doses for unilateral spinal anesthesia

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    Luiz Eduardo Imbelloni

    2004-06-01

    raquianestesia unilateral é a estabilidade hemodinâmica e sua rápida regressão, podendo ser uma nova opção para cirurgia ambulatorial.JUSTIFICATIVA Y OBJETIVOS: La raquianestesia unilateral puede presentar diversas ventajas, principalmente en el paciente ambulatorial. Bajas dosis de anestésicos locales, lenta velocidad de inyección subaracnóidea y posición de decúbito lateral son relacionados con la facilidad de producir distribución unilateral en la raquianestesia. En este estudio, fue verificada la posibilidad de obtenerse raquianestesia unilateral con bupivacaína a 0,5% isobárica. MÉTODO: La raquianestesia con 1 ml de bupivacaína isobárica a 0,5% (5 mg fue realizada a través de aguja 27G Quincke en 25 pacientes, estado físico ASA I y II sometidos a cirugías ortopédicas. La punción subaracnóidea fue realizada por vía lateral con el paciente en decúbito lateral, con el miembro a ser operado vuelto para arriba, y 1 ml de bupivacaína hipobárica fue inyectado en la velocidad de 1 ml.30s-1. Bloqueos sensitivo y motor (picada de aguja y escala de 0 a 3 fueron comparados entre el lado a ser operado y el contralateral. RESULTADOS: Los bloqueos motor y sensitivo entre el lado operado y el contralateral fueron significativamente diferentes en todos los tiempos evaluados. En el miembro operado todos los pacientes presentaran anestesia quirúrgica. En el miembro contralateral, a los 20 minutos, 9 pacientes presentaron bloqueo sensitivo; a los 40 minutos 18 pacientes y a los 60 minutos 17 pacientes. Por tanto, el bloqueo sensitivo unilateral ocurrió en 7 pacientes (28% y en ambos miembros en 18 pacientes (72%. Raquianestesia unilateral fue obtenida en 28% de los pacientes. Estabilidad hemodinámica fue observada en todos los pacientes. Ningún paciente desenvolvió cefalea pós-raquianestesia. CONCLUSIONES: La bupivacaína isobárica (5 mg proporciona predominante bloqueo unilateral después de 20 minutos en la posición lateral. La solución isobárica de

  4. Baixa dose de bupivacaína isobárica, hiperbárica ou hipobárica para raquianestesia unilateral Baja dosis de bupivacaína isobara, hiperbara o hipobara para anestesia raquidea unilateral Low dose isobaric, hyperbaric, or hypobaric bupivacaine for unilateral spinal anesthesia

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    Luiz Eduardo Imbelloni

    2007-06-01

    anestesia raquidea unilateral puede presentar ventajas principalmente en pacientes en régimen ambulatorial. Baja dosis de la solución anestésica, velocidad lenta de la inyección espinal y la posición lateral facilitan la obtención de la distribución unilateral en la anestesia raquidea. Se compararon las soluciones isobara, hiperbara e hipobara de bupivacaína para obtener la anestesia raquidea unilateral en pacientes sometidos a intervenciones quirúrgicas ortopédicas en régimen ambulatorial. MÉTODO: Ciento cincuenta pacientes fueron aleatoriamente separados en tres grupos para recibir 5 mg de bupivacaína a 0,5% isobara (Grupo Iso o 5 mg de bupivacaína a 0,5% hiperbara (Grupo Hiper o 5 mg de bupivacaína a 0,15% hipobara (Grupo Hipo. Las soluciones se administraron en el interespacio L3-L4 con el paciente en la posición lateral y permaneciendo en esa posición por 20 minutos. La anestesia sensitiva se evaluó por el test de la picada de la aguja. El bloqueo motor evaluado por la escala modificada de Bromage. Los dos bloqueos se compararon con el lado no operado y también entre sí. RESULTADOS: Se notó una diferencia significativa entre el lado operado y no operado en todos los tres grupos a los 20 minutos, pero se obtuvo una mayor frecuencia de anestesia raquidea unilateral con las soluciones hiperbara e hipobara de bupivacaína. Se observó bloqueo sensitivo y motor en 14 pacientes del Grupo Iso, 38 pacientes en el Grupo Hiper y 40 pacientes en el Grupo Hipo. No ocurrieron alteraciones hemodinámicas en ningún paciente. No se observó cefalea postpunción ni síntomas neurológicos transitorios. CONCLUSIONES: La anestesia raquidea con soluciones hipobara e hiperbara proporcionaron una mayor frecuencia de unilateralidad. Tras 20 minutos la solución isobara de bupivacaína se movió en el LCR resultando en apenas 28% de anestesia raquidea unilateral.BACKGROUND AND OBJECTIVES: Unilateral spinal anesthesia has its advantages, especially in patients undergoing

  5. Efeitos da associação entre pequenas doses subaracnóideas de morfina e cetoprofeno venoso e oral em pacientes submetidas à cesariana Efectos de la asociación entre pequeñas dosis subaracnóideas de morfina y cetoprofeno venoso y oral en pacientes sometidas a cesariana Effects of low spinal morphine doses associated to intravenous and oral ketoprofen in patients submitted to cesarean sections

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    Eliana Marisa Ganem

    2003-08-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Pequenas doses subaracnóideas de morfina são eficazes em reduzir a dor pós-operatória de pacientes submetidas à cesariana, com menor incidência de efeitos colaterais. O objetivo desta pesquisa foi avaliar a qualidade da analgesia pós-operatória e a ocorrência de efeitos colaterais em pacientes submetidas a cesarianas, sob anestesia subaracnóidea com bupivacaína hiperbárica e morfina nas doses de 0,05 mg e 0,1 mg, associadas ao cetoprofeno pelas vias venosa e oral. MÉTODO: Participaram do estudo 60 gestantes de termo, estado físico ASA I e II, que foram submetidas à cesariana eletiva. As pacientes foram divididas em dois grupos: grupo 1 - morfina 0,1 mg, grupo 2 - 0,05 mg, associada a 15 mg de bupivacaína hiperbárica. Todas receberam cetoprofeno (100 mg por via venosa no per-operatório e por via oral a cada 8 horas no primeiro dia de pós-operatório. As pacientes foram avaliadas 6, 12 e 24 horas após o término da cirurgia, com relação à intensidade da dor e presença de efeitos colaterais (sedação, prurido, náusea e vômito. A presença destes últimos também foi avaliada no per-operatório. RESULTADOS: Ambos os grupos foram idênticos quanto aos dados antropométricos e à duração da cirurgia e da anestesia. Também foram homogêneos com relação à intensidade da dor pós-operatória e à presença de prurido, sedação, náusea e vômito. CONCLUSÕES: A morfina, nas doses de 0,05 mg e 0,1 mg administradas no espaço subaracnóideo, associada ao cetoprofeno pelas vias venosa e oral, apresentou a mesma qualidade de analgesia pós-operatória e determinou a mesma ocorrência de efeitos colaterais.JUSTIFICATIVA Y OBJETIVOS: Pequeñas dosis subaracnóideas de morfina son eficaces en reducir el dolor pos-operatorio de pacientes sometidas a cesariana, con menor incidencia de efectos colaterales. El objetivo de esta pesquisa fue evaluar la calidad de la analgesia pos-operatoria y la ocurrencia

  6. Dose de bupivacaína subaracnóidea necessária para cesariana é semelhante em mulheres obesas e com peso normal Las dosis de bupivacaína intratecal necesarias para cesáreas en mujeres obesas son similares a las usadas en mujeres con peso normal Dose requirement of intrathecal bupivacaine for cesarean delivery is similar in obese and normal weight women

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    Yung Lee

    2009-12-01

    mujeres obesas y con peso normal. MÉTODO: Evaluamos embarazadas con peso normal (IMC 30 kg.m-2, con feto único a término, sometidas a cesáreas de elección. Ese fue un estudio mono ciego y de ubicación secuencial, usando el método up-down (modificado por la regla de Narayana. Todas las pacientes recibieron bloqueo combinado raquiepidural con administración intratecal de dosis variables de bupivacaína hiperbárica a 0.75% más 10 µg de fentanil y 100 µg de morfina. La primera paciente recibió 9 mg de bupivacaína. La anestesia se suplementó cuando fue necesario, a través de un catéter epidural. El éxito de la anestesia, definido como bloqueo sensitivo hasta por lo menos T6, sin necesidad de anestesia suplementaria, fue el objetivo primario. La ED95 para un resultado satisfactorio fue determinada por un modelo logístico sin transformación logarítmica de las dosis. RESULTADOS: Veinte y cuarto embarazadas con peso normal y dieciséis embarazadas obesas participaron en este estudio. La ED95 estimada para todas las pacientes fue de 12,92 mg (IC 95%: 11,49 a 34,77. La ED95 estimada para las embarazadas con peso normal y las embarazadas obesas fue similar, 12,78 mg (IC 95%: 10,75 a + infinito y 11,86 mg (CI 95%: 11,31 a 15,61, respectivamente. CONCLUSIONES: Si la anestesia raquídea con inyección única es utilizada en cesáreas, las pacientes con peso normal y obesas deben recibir dosis parecidas de bupivacaína hiperbárica. A pesar de que no fuimos capaces de determinar con exactitud la ED95 en nuestro estudio, sí que podemos afirmar que es de por lo menos 11,49 mg.BACKGROUND AND OBJECTIVES: The effect of BMI on the spread of intrathecal bupivacaine is controversial. This study assessed the ED95 of intrathecal bupivacaine for elective cesarean delivery in obese and normal weight women. METHODS: We studied normal weight (BMI 30 kg.m-2 women with singleton term pregnancies undergoing elective cesarean delivery. The study was conducted as a single blinded, up

  7. Clonidina como medicação pré-anestésica em facectomias: comparação entre as doses de 100 µg e 200 µg La clonidina como medicación preanestésica en facectomías: comparación entre las dosis de 100 µg y 200 µg Clonidine as pre-anesthetic medication in cataract extration: comparison between 100 µg and 200 µg

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    José Roquennedy Souza Cruz

    2009-12-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: Avaliar a sedação, a pressão intraocular e as alterações hemodinâmicas com o uso de doses baixas de clonidina, 100 µg e 200 µg por via oral, como medicação pré-anestésica para operações de catarata em regime ambulatorial. MÉTODO: O trabalho foi realizado pela Universidade Federal de São Paulo, sendo um estudo clínico aleatório e duplamente encoberto em 60 pacientes, de ambos os sexos, estado físico ASA 1 e 2, com idade mínima de 18 anos e máxima de 80 anos. Os pacientes foram divididos em três grupos: placebo, clonidina 100 µg e 200 µg. As medidas de pressão intraocular, frequência cardíaca e pressão arterial, além da avaliação de sedação, foram feitas antes e após 90 minutos da administração da clonidina. Os níveis de sedação foram classificados de acordo com a escala de sedação de Ramsay. RESULTADOS: Pacientes que receberam placebo e 100 µg de clonidina não apresentaram redução da frequência cardíaca com diferença estatística significativa, enquanto os que receberam 200 µg de clonidina, sim. Os que receberam clonidina na dose de 200 µg apresentaram redução na pressão arterial sistólica e diastólica (p JUSTIFICATIVA Y OBJETIVOS: Evaluar la sedación, la presión intraocular y las alteraciones hemodinámicas con el uso de bajas dosis de clonidina, 100 µg y 200 µg por vía oral, como medicación preanestésica para operaciones de catarata en el ambulatorio. MÉTODO: El trabajo fue realizado por la Universidad Federal de São Paulo, siendo un estudio clínico aleatorio y doble ciego en 60 pacientes de los dos sexos, estado físico ASA 1 y 2, con edad mínima de 18 años y máxima de 80 años. Los pacientes fueron divididos en tres grupos: placebo, clonidina 100 µg y 200 µg. Las medidas de presión intraocular, frecuencia cardiaca y presión arterial, además de la evaluación de sedación, fueron hechas antes y después de los 90 minutos iniciales en que se

  8. Sufentanil subaracnóideo associado à bupivacaína hiperbárica para analgesia de parto: É possível reduzir a dose do opióide? Sufentanil subaracnóideo asociado a la bupivacaína hiperbárica para analgesia de parto: Es posible reducir la dosis del opioide? Spinal sufentanil associated to hyperbaric bupivacaine: Is it possible to decrease opioid dose?

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    Eduardo Tsuyoshi Yamaguchi

    2004-04-01

    Full Text Available JUSTIFICATIVA E OBJETIVOS: A adição de bupivacaína isobárica a doses menores de sufentanil por via subaracnóidea promove analgesia de qualidade satisfatória, com menor incidência de efeitos colaterais. O objetivo do estudo foi avaliar a qualidade da analgesia e a incidência de efeitos colaterais de doses reduzidas de sufentanil subaracnóideo associados à bupivacaína hiperbárica em analgesia de parto. MÉTODO: Foram estudadas prospectivamente 69 gestantes de termo em trabalho de parto. As gestantes foram aleatoriamente divididas em três grupos que receberam, no espaço subaracnóideo, a combinação de 2,5 mg de bupivacaína hiperbárica e 1 ml de solução fisiológica (Grupo Controle; 2,5 mg de bupivacaína hiperbárica e 2,5 µg de sufentanil (Grupo S2,5 ou 2,5 mg de bupivacaína hiperbárica e 5 µg de sufentanil (Grupo S5. A dor, de acordo com a escala analógico visual (EAV de dor e a incidência de efeitos colaterais foram avaliadas a cada 5 minutos nos primeiros quinze minutos e a seguir a cada 15 minutos até o nascimento. O estudo terminava com o nascimento, ou quando a paciente solicitava medicação analgésica de resgate (EAV > 3 cm. RESULTADOS: Os grupos S2,5 e S5 apresentaram maior duração de analgesia (67,2 ± 38,6 e 78,9 ± 38,7 minutos, respectivamente e maior porcentagem de pacientes com analgesia efetiva (100% e 95,6%, respectivamente que o grupo Controle, no qual a duração média de analgesia foi de 35,9 ± 21,6 minutos (p JUSTIFICATIVA Y OBJETIVOS: La adición de bupivacaína isobárica a dosis menores de sufentanil por vía subaracnóidea promueve analgesia de cualidad satisfactoria, con menor incidencia de efectos colaterales. El objetivo del estudio fue evaluar la calidad de la analgesia y la incidencia de efectos colaterales de dosis reducidas de sufentanil subaracnóideo asociados a bupivacaína hiperbárica en analgesia de parto. MÉTODO: Fueron estudiadas prospectivamente 69 embarazadas de término en

  9. Administración oral de preparado parenteral de vitamina K en anticoagulación excesiva por warfarina

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    Yoleima Lozada

    2012-04-01

    Full Text Available La warfarina es frecuentemente usada en la terapia anticoagulante actual, su acción debe ser monitorizada usando el tiempo de protrombina expresado como International Normalized Ratio (INR; cuando se excede el rango de seguridad se puede administrar vitamina K (Vit-K, preferentemente por vía oral. Dicha presentación no está disponible en Venezuela. Se realizó un ensayo clínico, doble ciego, donde a 20 pacientes, edad 18-60 años, sin sangrado e INR inicial de 6 a 10 inclusive; les fue suspendida la warfarina e inmediatamente agrupados al azar a recibir dosis única de Vit-K (oral 1.25mg de Vit-K fraccionada de una presentación parenteral o placebo. El punto final primario, INR < 3.5 a las 24 horas de administrar la dosis, se alcanzó en 70% de los pacientes en Vit-K y 20% en placebo. La reducción absoluta del riesgo y su intervalo de confianza de 95%: RAR (IC95% = 50% (14.4 a 85.6 ρ = 0.028; NNT (IC95% = 2(1.3 a 6.9; no se registraron eventos adversos, ni INR < 2 luego de 24 horas de tratamiento. Los resultados obtenidos son consistentes con estudios donde se administró Vit-K en preparación específica para vía oral. Así la Vit-K en presentación parenteral, administrada por vía oral, es más efectiva y segura que simplemente detener la administración de warfarina para revertir la excesiva anticoagulación, en donde no exista presentación específica oral de Vit-K o ésta sea muy costosa.

  10. Development of tools to manage the operational monitoring and pre-design of the NPP-LV cycle; Desarrollo de herramientas para administrar el seguimiento operativo y el pre-diseno del ciclo de la CLV

    Energy Technology Data Exchange (ETDEWEB)

    Perusquia, R.; Arredondo S, C.; Hernandez M, J. L.; Montes T, J. L.; Castillo M, A.; Ortiz S, J. J., E-mail: raul.perusquia@inin.gob.mx [ININ, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2015-09-15

    This paper presents the development of tools to facilitate the management so much, the operational monitoring of boiling water reactors (BWR) of the nuclear power plant of Laguna Verde (NPP-LV) through independent codes, and how to carry out the static calculations corresponding to process of optimized pre-design of the reference cycle next to current cycle. The progress and preliminary results obtained with the program SACal, developed at Instituto Nacional de Investigaciones Nucleares (ININ), central tool to achieve provide a management platform of the operational monitoring and pre-design of NPP-LV cycle are also described. The reached preliminary advances directed to get an Analysis center and automated design of fuel assembly cells are also presented, which together with centers or similar modules related with the fuel reloads form the key part to meet the targets set for the realization of a Management Platform of Nuclear Fuel of the NPP-LV. (Author)

  11. Validación de la dosis de diálisis medida con el Monitor de Aclaración en Linea (OCM y el Kt/v de Daugirdas ‘93: Aplicación práctica en una unidad de hemodiálisis Assessment of the average dose of dialysis with the On line Clarification Monitor (OCM and the Daugirdas 93 Kt/v: Its practical application in a hemodialysis unit

    Directory of Open Access Journals (Sweden)

    MJ. Rodríguez Cabrera

    2004-03-01

    Full Text Available Introducción: La morbimortalidad de los pacientes en tratamiento con hemodiálisis depende, entre otras cosas, de la edad, enfermedad de base y calidad del tratamiento. El índice Kt/V es el parámetro de referencia de la medición de la dosis de diálisis. El método de la dialisancia iónica (OCM,FMC determina el Kt/V en tiempo real, mediante el aclaramiento de electrolitos. La evaluación de la relación entre Kt/V medido por OCM y método Daugirdas 93 ha sido el objetivo del estudio. Material y Métodos: Se estudiaron prospectivamente 24 pacientes anúricos, de edad 64.75 ±18.24 años, 16.7% mujeres y 20.8% diabéticos. Las membranas utilizadas fueron polisulfona de alta permeabilidad (1.8 m² y helixone (1.4 m². El cálculo del Kt/V de Daugirdas 93 se realizó de acuerdo con NKF-DOQI y el de OCM se determinó en la sesión intermedia durante 3 semanas consecutivas. Los datos fueron procesados con SPSS 11.0 utilizando regresión lineal, análisis dela varianza y t-student. Se consideró estadísticamente significativo pIntroduction: The morbimortality rate of patients undergoing hemodialysis treatment depends on, among other things, age, base illness and the quality of treatment. The Kt/V index is the reference parameter for the measurement of the dose of dialysis. The method of ionic dialysis (OCM, FMC determines the Kt/V in real time, by clarifying the electrolytes. The objective of this study was theevaluation of the relationship between average Kt/V by OCM and by the Daugirdas 93. Material and Methods: 24 anuric patients were studied, of ages 64.75 ±18.24, 16.7% women and 20.8% diabetics. The membranes used were highly permeable polysulsphone (1.8m² and helixone(1.4m² The calculation of the Kt/V by the Daugirdas 93 was carried out in accordance with NFK-DO-QI and that of the OCM was determined in the intermediate session for 3 consecutive weeks. The data were processed with the SPSS 11.0 using lineal regression, analysis of the

  12. Eficácia analgésica do uso de dose alta de morfina intra-articular em pacientes submetidos à artroplastia total de joelho Eficacia analgésica del uso de dosis alta de morfina intra-articular en pacientes sometidos a la artroplastia total de rodilla Analgesic efficacy of the intra-articular administration of high Doses of morphine in patients undergoing total knee arthroplasty

    Directory of Open Access Journals (Sweden)

    João Batista Santos Garcia Garcia

    2010-02-01

    demostrado que las dosis mayores generan mejores resultados y consecuentemente, un menor consumo postoperatorio de analgésico, caracterizando así, el efecto dosis-dependiente en la acción periférica. Fue realizado un estudio controlado, aleatorio y doble ciego para evaluar la eficacia de 10 mg de morfina por vía intraarticular en pacientes sometidos a la artroplastia total de rodilla. MÉTODO: Se evaluaron 50 pacientes sometidos a la artroplastia total de rodilla, distribuidos aleatoriamente en dos grupos: el grupo tratamiento recibió 10 mg (1 mL de morfina por vía intra-articular diluido en 19 mL de solución fisiológica al 0,9% (SF, mientras que el grupo control recibió una inyección intra-articular con 20 mL de SF, ambos después del cierre de la cápsula articular, al final de la operación. La morfina subcutánea bajo demanda, estuvo disponible para el dolor residual. Se evaluaron las siguientes variables: intensidad del dolor graduada en la Escala Numérica (EN a las 2h (M1, 6h (M2, 12h (M3 y 24h (M4, después de la inyección IA; tiempo para la primera solicitación de analgésico; y consumo de analgésicos y efectos adversos. CONCLUSIONES: El grupo tratamiento presentó menores valores en la EN que el grupo control en M1 y M2, mientras que en los otros momentos, no se registró ninguna diferencia significativa. El intervalo para la primera solicitación de analgésicos fue significantemente mayor en el grupo tratamiento y el consumo de analgésicos en las primeras 24 horas fue menor en ese grupo. No hubo diferencia entre la incidencia de efectos adversos entre los grupos. Llegamos a la conclusión, de que 10 mg de morfina redujeron el dolor del postoperatorio entre 2 y 6 horas después de aplicada la inyección IA, y se generó un periodo mayor sin analgésico de rescate reduciendo su consumo en las primeras 24 horas.BACKGROUND AND OBJECTIVES: Although the efficacy of intraarticular (IA morphine is still controversial, it has been shown that higher doses

  13. Dose reconstruction starting from the pre-dose effect of quartz: combined procedure of additive dose and multiple activation; Reconstruccion de dosis a partir del efecto pre-dosis del cuarzo: procedimiento combinado de dosis aditiva y activacion multiple

    Energy Technology Data Exchange (ETDEWEB)

    Correcher, V.; Gomez R, J. M.; Delgado, A. [Centro de Investigaciones Energeticas Medioambientales y Tecnologicas, Av. Complutense 22, 28040 Madrid (Spain); Garcia G, J. [Consejo Superior de Investigaciones Cientificas, Museo Nacional de Ciencias Naturales, Jose Gutierrez Abascal No. 2, 28006 Madrid (Spain)], e-mail: v.correcher@ciemat.es

    2009-07-01

    The pre-dose effect of the 110 C thermoluminescence (Tl) peak of quartz gives rise to the use of a sensitive technique to estimate of low-level doses under retrospective conditions. However, one can appreciate how aliquots of quartz, from the same mineral fraction, display different sensitivities. In this sense, we herein report on a new measurement protocol based on the aforementioned pre-dose effect. Such procedure includes additive dose and multiple activation steps allows to determine simultaneously the sensitivity changes induced by the thermal activation and the Tl dose dependence. This behaviour let calculate the field accrued dose by interpolation thus permitting an increase of both precision and accuracy. (Author)

  14. Dosimetric systems of high dose, dose rate and dose uniformity in food and medical products; Sistemas dosimetricos de altas dosis, tasa de dosis y uniformidad de dosis en alimentos y producto medico

    Energy Technology Data Exchange (ETDEWEB)

    Vargas, J.; Vivanco, M.; Castro, E., E-mail: jvargas@ipen.gob.pe [Instituto Peruano de Energia Nuclear, Av. Canada 1470, San Borja, Lima (Peru)

    2014-08-15

    In the Instituto Peruano de Energia Nuclear (IPEN) we use the chemical dosimetry Astm-E-1026 Fricke as a standard dosimetric system of reference and different routine dosimetric systems of high doses, according to the applied doses to obtain the desired effects in the treated products and the doses range determined for each type of dosimeter. Fricke dosimetry is a chemical dosimeter in aqueous solution indicating the absorbed dose by means an increase in absorbance at a specific wavelength. A calibrated spectrophotometer with controlled temperature is used to measure absorbance. The adsorbed dose range should cover from 20 to 400 Gy, the Fricke solution is extremely sensitive to organic impurities, to traces of metal ions, in preparing chemical products of reactive grade must be used and the water purity is very important. Using the referential standard dosimetric system Fricke, was determined to March 5, 2013, using the referential standard dosimetric system Astm-1026 Fricke, were irradiated in triplicate Fricke dosimeters, to 5 irradiation times (20; 30; 40; 50 and 60 seconds) and by linear regression, the dose rate of 5.400648 kGy /h was determined in the central point of the irradiation chamber (irradiator Gamma cell 220 Excel), applying the decay formula, was compared with the obtained results by manufacturers by means the same dosimetric system in the year of its manufacture, being this to the date 5.44691 kGy /h, with an error rate of 0.85. After considering that the dosimetric solution responds to the results, we proceeded to the irradiation of a sample of 200 g of cereal instant food, 2 dosimeters were placed at the lateral ends of the central position to maximum dose and 2 dosimeters in upper and lower ends as minimum dose, they were applied same irradiation times; for statistical analysis, the maximum dose rate was 6.1006 kGy /h and the minimum dose rate of 5.2185 kGy /h; with a dose uniformity of 1.16. In medical material of micro pulverized bone for implants with a weight of 1393 g the maximum dose rate of 6.5276 kGy /h, the minimum dose rate of 3.5684 kGy /h and the dose uniformity of 1 83 were determined. Then, based on the minimum dose rate irradiation times were calculated for different doses to evaluate in the microbial decontamination of food (3, 5, 8 and 12 kGy) and the sterilization of medical material by radiation (15, 20, 25 and 40 kGy), corroborating the applied doses with routine dosimeters of ethanol chlorobenzene (1-100 kGy) and perspex network 4034 (5-50 kGy). Other routine dosimeters used in different applications according to the doses range are Gafchromic Hd (40-400 Gray) for induced mutation by radiation and the development of new varieties of plants, the sterile insect technique to eradicate pests, quarantine treatment to solve plant health problems. Ambar Perspex 3042 C (3-15 kGy) for microbial decontamination of dried foods, spices, aromatic herbs, medicinal plants, etc. GEX B-3000 (1-140 kGy) and FWT (0.5-200 kGy) for sterilization of medical and pharmaceutical material, cosmetics, biological tissues, etc. The minimum dose rate allowing to calculate the irradiation times to apply the desired dose for the research or industrial processes, taking into account the density and geometry of product. Is notorious the difference in dose uniformity in food (1, 16) and medical material (1, 83) due to the geometry and relative density of the products within the irradiation cylinder. (author)

  15. Diclofenaco por via muscular ou retal associado com baixas doses de morfina subaracnóidea para analgesia pós-operatória em cesarianas Diclofenaco por vía muscular o rectal asociado con bajas dosis de morfina subaracnóidea para analgesia pós-operatoria en cesáreas Intramuscular versus rectal diclofenac associated with low dose spinal morphine for post-cesarean analgesia

    Directory of Open Access Journals (Sweden)

    Mônica Maria Siaulys Capel Cardoso

    2002-11-01

    mejor forma de su administración no es conocida. Este estudio evaluó la calidad de la analgesia pós-operatoria de diferentes esquemas de administración de diclofenaco, en pacientes sometidas a cesárea bajo raquianestesia con bupivacaína y morfina. MÉTODO: Después del final de la cirugía, las pacientes fueron distribuidas aleatoriamente en tres grupos que recibieron diclofenaco como se sigue: G50VR (n=62, 50 mg por vía rectal; G50IM (n=62, 50 mg por vía muscular y G75IM (n=62, 75 mg por vía muscular. El dolor fue evaluado con una escala analógica visual de 0-10 cm (EAV a cada 30 minutos en las primeras seis horas y meperidina, vía venosa, fue administrada como medicación de rescate siempre que la EAV fuera igual o mayor que 3 cm. RESULTADOS: En el intervalo entre 30 y 150 minutos después de la administración de diclofenaco, la media de la intensidad de dolor en el grupo G50VR (0,9 ± 1,4; 1,4 ± 1,4; 1,3 ± 1,5; 1,3 ± 1,2 y 1,5 ± 3,3 cm fue mayor cuando comparada con las del G50IM (0,4 ± 0,8; 0,5 ± 0,8; 0,7 ± 1,0; 0,7 ± 1,1 y 0,7 ± 1,1 cm y G75IM (0,4 ± 0,8; 0,7 ± 1,3; 0,7 ± 1,1; 0,8 ± 1,2 y 0,7 ± 1,0 cm. La necesidad de meperidina de rescate (43,5% y el consumo total de meperidina (21,3 ± 28,9 mg fueron mayores en el G50VR, cuando comparados con G50IM (21% y 8,2 ± 18,2 mg y G75IM (19,4% y 6,8 ± 16,7 mg. CONCLUSIONES: Cuando combinada con bajas dosis de morfina subaracnóidea, la administración de diclofenaco por vía muscular promueve mejor analgesia pós-operatoria que por vía rectal. Después de eso, parece haber un efecto techo para esta droga, ya que no se observan ventajas con dosis superiores a 50 mg por vía muscularBACKGROUND AND OBJECTIVES: Diclofenac has been used in combination with spinal opioids to control postoperative pain; however, the best regimen of its administration is not known. This study evaluated the quality of postoperative analgesia of different regimens of diclofenac administration, in patients submitted to

  16. Dose in water or dose in tissue. Still a theme of debate; Dosis en agua o dosis en tejido-todavia un tema de debate

    Energy Technology Data Exchange (ETDEWEB)

    Andreo, P.

    2015-07-01

    It is shown that the method used so Siebers to convert to Dw Dt, or vice versa, is incorrect. Due to the substantial difference between the electron fluence in water and various tissues, an additional correction for creep, several percent for some bone tissues, which is ignored in the method Siebers needed. Correction is necessary even if an environment that clinically adopted dose in tissue due to normalization of TPS because the beams are always calibrated in terms of absorbed dose in water. (Author)

  17. Cytogenetics dosimetry: dose-response curve for low doses of X-ray; Dosimetria citogenetica: curva dosis-respuesta para bajas dosis de rayos-X

    Energy Technology Data Exchange (ETDEWEB)

    Lara, Virginia E. Noval; Pineda Bolivar, William R.; Riano, Victor M. Pabon, E-mail: venovall.15@hotmail.com, E-mail: wrpineda@misena.edu.co, E-mail: vmpabonr@udistrital.edu.co [Universidad Distrital Francisco Jose de Caldas (UD), Bogota (Colombia). Grupo de Investigacion en Ciencia y Tecnologia Nuclear; Ureana, Cecilia Crane, E-mail: cecicrane@yahoo.com [Instituto Nacional de Salud (INS), Bogota (Colombia). Laboratorio de Genetica

    2013-07-01

    The purpose of this study was to conduct a preliminary study for the standardization in the future, the dose-response curve for low doses of X-rays, through the analysis of in vitro cultures of peripheral blood samples of 3 men and 3 women occupationally not exposed to artificial sources of ionizing radiation, age 18-40 years, where possible nonsmokers.

  18. Perbandingan Efektifitas Ketamin Dosis 0,12 Mg/Kg/Jam Dan Fentanil Dosis 1 Mcg/Kg/Jam Kontinu Intravena Untuk Penanganan Nyeri Pascabedah

    OpenAIRE

    Nurmadi, Rusdian

    2016-01-01

    Objective : This research aimed to compare the postoperative analgesic effectiveness between continuous intravenous infusion of ketamine 0,12 mg/kg/hour and fentanyl 1 mcg/kg/hour. Method: Double-blinded, randomized clinical trial in 40 patients, PS-ASA 1-2 post elective laparotomy with general anesthesia in Haji Adam Malik Hospital. The samples were divided into two groups, each composed of 20 patients. The control group were patients who receive continuous intravenous infusion of fentany...

  19. Avaliação da cetamina racêmica e do isômero S(+, associados ou não a baixas doses de fentanil, na balneoterapia do grande queimado Evaluación de la cetamina racémica y del isómero S(+, asociados o no a bajas dosis de fentanil, en la balneoterapia del gran quemado Assessment of the use of racemic ketamine and its S(+ isomer, associated or not with low doses of fentanyl, in balneotherapy for major burn patients

    Directory of Open Access Journals (Sweden)

    Fernando Antônio de Freitas Cantinho

    2009-08-01

    desencadena un estímulo doloroso muy intenso. Este estudio tuvo el objetivo de evaluar la seguridad y la eficacia de diferentes combinaciones de fármacos en la anestesia para balneoterapia. MÉTODO: Con la aprobación del Comité de Ética, fueron estudiados 200 procedimientos de balneoterapia en 87 grandes quemados adultos. En todos los casos se usó el midazolam. Se utilizaron frascos numerados de la cetamina, y cuando se usaron no se sabía si era racémica o S (+. Todas las mañanas, se hacía el sorteo para saber si los procedimientos de ese día serían comandados por el fentanil o no. Quedaron establecidos cuatro grupos: ISO/sf (isómero S(+ sin el fentanil, ISO/cf (isómero S(+ con el fentanil, RAC/sf (cetamina racémica sin el fentanil y RAC/cf (cetamina racémica con el fentanil. Las dosis iniciales propuestas fueron: midazolam 0,06 mg.kg-1, cetamina 1,0 a 1,1 mg.kg-1, fentanil 0,8 ¼g.kg-1; las dosis adicionales se administraban conforme a lo necesario. RESULTADOS: En solo un caso hubo recuerdo de dolor durante la balneoterapia. En el grupo que recibió la cetamina S(+, la añadidura del fentanil no mostró ventajas. Asociado a la forma racémica, el fentanil redujo la dosis total y el número de bolo de la cetamina. La extensión de la superficie corporal quemada fue el principal determinante de la intensidad de dolor posprocedimiento. La menor intensidad de dolor posprocedimiento, fue el principal factor considerado por el paciente para su satisfacción por la anestesia recibida. CONCLUSIONES: Las cuatro diferentes combinaciones de fármacos fueron seguras y permitieron la ausencia de dolor durante la balneoterapia. Las características no vinculadas directamente a los anestésicos, tuvieron una mayor importancia en la definición del dolor posprocedimiento, que fue la principal característica considerada por el gran quemado para definir su satisfacción con la anestesia recibida.BACKGROUND AND OBJECTIVES: The care of the wounds of major burn patients triggers

  20. Estudo prospectivo das repercussões de baixas doses de remifentanil na função sinoatrial e na condução e refratariedade cardíaca Estudio prospectivo de las repercusiones de bajas dosis de remifentanil en la función sinoatrial en la conducción y refractariedad cardiaca Prospective study on the repercussions of low doses of remifentanil on sinoatrial function and in cardiac conduction and refractory period

    Directory of Open Access Journals (Sweden)

    Simone Soares Leite

    2007-10-01

    recuperación del nódulo sino-atrial (p = 0,0004, del período refractario del atrio derecho (p = 0,001 y del período refractario del nódulo atrio ventricular (p = 0,0001, pero no hubo disminución de la frecuencia cardíaca basal entre M0 e M1. CONCLUSIONES: El remifentanil altero las variables electrofisiológicas cardíacas, lo que en dosis mayores que las estudiadas podría causar bradicardia sinusal, asistolia y disturbios de conducción.BACKGROUND AND OBJECTIVES: Remifentanil is an opiod with fast onset of action and short acting, and its use in short-duration procedures has increased in the last few years. Bradycardia and asystole are among the side effects reported. The objective of this study was to evaluate the effects of this drug in cardiac conduction and refractory period in human beings. METHODS: A prospective study with 16 patients, ages 18 to 65, both genders, ASA I to III, undergoing elective intracardiac electrophysiological study, was undertaken. Patients with disorders of the sinoatrial node and those with severe cardiac blocks were excluded. In the laboratory of electrophysiology, patients were sedated with midazolam (0.03 mg.kg-1 after 5 minutes the degree of sedation and degree of pain, systolic and diastolic blood pressure, heart rate and respiratory rate, and oxygen saturation were evaluated. The electrophysiologist evaluated cardiac conduction (duration of the QRS complex, and AA, AH, HV, and PA intervals, duration of sinoatrial node recovery, and cardiac refractory period (refractory period of the right atrium, right ventricle, and atrioventricular node. After the initial measurements, remifentanil was administered (bolus of 0.5 µg.kg-1 + infusion of 0.05 µg.kg-1.min-1 and, after 20 minutes, the same parameters were evaluated. RESULTS: There was a reduction in systolic and diastolic blood pressure (p = 0.0001 between M0 and M1, and significant differences in respiratory rate and oxygen saturation, which were not statistically significant. The

  1. Influência de variáveis do treinamento contra-resistência sobre a força muscular de idosos: uma revisão sistemática com ênfase nas relações dose-resposta Influencia de las variables de entrenamiento contra-resistencia sobre la fuerza muscular de ancianos: una revisión sistemática con énfasis en las relaciones dosis-respuesta Influence of counter-resistance training variables on elderly muscular strength: a systematic review with emphasis on dose/response relationships

    Directory of Open Access Journals (Sweden)

    Nádia Lima da Silva

    2007-02-01

    tiene aún muy claro cuál es la mejor combinación de esas variables para una óptima relación dosis-respuesta en personas ancianas. El objetivo de este estudio ha sido analizar las investigaciones sobre entrenamiento de fuerza para ancianos, mediante una revisión sistemática, con el propósito de identificar tendencias comunes en términos de efectos del entrenamiento provocados por la manipulación de estas variables. Una vez definidos los criterios de inclusión, fueron seleccionados 22 estudios, agrupados por semejanza de tratamiento (nº de series, frecuencia semanal, intensidad, intervalos y orden de los ejercicios. Técnicas de estadística descriptiva auxiliaron en la determinación de posibles tendencias en las relaciones dosis-respuesta. Al identificarse, esas tendencias fueron analizadas cualitativamente. De todas las variables revisadas, solamente para la intensidad de sobrecarga fueron encontradas evidencias, lo que permite afirmar que cargas mayores serían más eficaces para inducir un aumento de fuerza a esa edad. En relación a las demás variables, los resultados disponibles en la literatura no dan respaldo para realizar inferencias seguras respecto al mejor delineamiento de programas de entrenamiento que alíen, al mismo tiempo, efectividad y seguridad. Por tanto, se recomienda que estudios posteriores sean realizados para comparar experimentalmente los efectos de la manipulación de esas variables sobre la fuerza muscular de ancianos.Muscular force is considered an important component of physical exercise programs. The results of this type of training depend on the combination of the number of repetitions, series, overload, sequence and intervals between series and exercises. However, it is still not very clear yet what the best combination of these variables for a good stimulus/response relationship in elderly people is. The objective of this study was to analyze the research on power-training for elderly people by means of systematic revision

  2. Study on the possibility of using a {sup 60} Co therapeutical unity in Intensity Modulated Radiotherapy (IMRT); Estudo sobre a possibilidade do uso de uma unidade terapeutica de {sup 60}Co em IMRT

    Energy Technology Data Exchange (ETDEWEB)

    Dantas, Samuel Cesar

    2009-06-15

    With the increasing advances in complex treatment techniques, there is a tendency to obtain more sophisticated equipment to deliver the dose. The use of 3D conformal radiotherapy is now routine in many radiotherapy facilities as well as the utilization of intensity modulated radiotherapy (IMRT). Both are usually implemented using linear accelerators equipped with multi leaves collimators, which create the conformity and the fluence distributions required. However, the complexity of increasingly sophisticated equipment, such as linear accelerators, requires a frequent quality control of their operation, as well as a detailed and constant maintenance. Even carrying out these procedures, the accelerators may present technical problems interrupting for a long time a treatment using the IMRT technique. Despite the clear practical and technological advantages that linear accelerators have on {sup 60}Co irradiators, these devices occupy an important place in radiotherapy, mainly due to the low cost of equipment installation and maintenance when compared to those required by accelerators. Many radiotherapy facilities that work with IMRT have tele therapeutic isocentric {sup 60}Co units. In principle, such equipment would be able to be used for treatment with IMRT using compensating blocks to modulate the beam. This study investigates this possibility and shows that it is feasible. The comparison of treatment plans of a head-and-neck cancer and other of a cancer of the central nervous system, based on a {sup 60}Co irradiator and a Linac 2300 C/D, presented advantages for the {sup 60}Co irradiator. Furthermore; the delivery of dose obtained with the two systems showed themselves equivalent when compared to their respective plans. (author)

  3. Valutazione con MMPI 2 Di. Un campione di pazienti borderline della comunità terapeutica "Villa Ratti" e relazione con le percentuali di interventi del progetto terapeutico-riabilitativo

    OpenAIRE

    DI FRANCESCO

    2013-01-01

    ABSTRACT: PERSONALITÀ E RIABILITAZIONE PSICHIATRICA INTRODUZIONE: i percorsi riabilitativi delle comunità terapeutiche sono mirati a riacquisire un’adeguata funzionalità personale, relazionale e lavorativa, consentendo il reinserimento sociale dei pazienti. Tuttavia in letteratura non sono presenti dati sulla predisposizione alla partecipazione alle attività previste dai piani di cura individualizzati. Pertanto si indaga la relazione tra i tratti di personalità dei pazienti della Comunità...

  4. Bio markers and Anti-EGFR therapies for Krads wild-type tumors in metastatic colorectal cancer patients; Biomarcadores y terapeutica ANTI-EGFR en el cancer colorrectal metastasico en pacientes con K-Ras no mutado

    Energy Technology Data Exchange (ETDEWEB)

    Diaz Rubio Garcia, E.

    2009-07-01

    The natural history of metastasis colorectal cancer has being clearly modified in terms of response rate, time to progression and overall survival, once the anti-EGFR monoclonal antibodies (cetuximab and panitumumab) have emerged in combination with the standard cytotoxic chemotherapy (FOLFOX and FOLFIRI). However, the benefit from cetuximab and panitumumab is only confined to KRAS-wild type (KRAS-wt) colorectal tumors, while KRAS mutated tumors do not respond to these drugs. The 65 % of colorectal tumors are KRAS-wt tumors, but efficacy of antiEGFR therapies is detected only in 60-70 % of these KRAS-wt tumors. Other biomarkers and molecular pathways must be involved in the response of the antiEGFR therapies for the KRAS-wt colorectal tumors, such as the EGFR ligands, the EGFR-phosphorilated levels, the number of EGFR copies, the status of the KRAS effected B-RAF and the alternative intracellular signaling pathways PIK3CA/PTEN/AKT and JAK/STAT. A battery of these biomarkers is needed to select the most sensitive patients to the antiEGFR therapies. This pattern may represent a novel favorable cost-effectiveness tool to develop tailored treatments. A review of these biomarkers and molecular pathways, involved in the antiEGFR therapies response, is performed. (Author) 68 refs.

  5. Measurement of Solution Viscosity via Diffusion-Ordered NMR Spectroscopy (DOSY)

    Science.gov (United States)

    Li, Weibin; Kagan, Gerald; Hopson, Russell; Williard, Paul G.

    2011-01-01

    Increasingly, the undergraduate chemistry curriculum includes nuclear magnetic resonance (NMR) spectroscopy. Advanced NMR techniques are often taught including two-dimensional gradient-based experiments. An investigation of intermolecular forces including viscosity, by a variety of methods, is often integrated in the undergraduate physical and…

  6. Variation of surface dose in CT; Variacion de la dosis superficial en Tomografia Computarizada

    Energy Technology Data Exchange (ETDEWEB)

    Aviles Lucas, P.; Castellano, I. A.; Dance, D. R.; Vano Carruana, E.; Prieto Martin, C.

    2003-07-01

    An experimental study has been made of the variations of the air kerma-length product at the surface of a phantom exposed in a CT scanner using clinical parameters. the effect of patient size, position within the gantry plane and beam-shaping filter type was studied using three different elliptical phantoms. A dose reduction technique based on a sinusoidal tube current modulation system was also investigated. the result of the variation of the surface dose was analysed for the case of CT fluoroscopy procedures. The surface air kerma-length product was shown to be independent of phantom size (within experimental error) but decreases as the surface moves vertically away from the iso centre. The major contributor to this variation the beam-shaping filter. The possibility of underestimating the surface dose if an AAPM body phantom is used (a 36% increase for the head phantom) is an indirect result of the previous conclusion when applied to CT fluoroscopy. This highlights the importance of considering the size and position of the patient when measuring the does. Finally, when the tube current modulation system was used, the maximum surface dose reduction was 18%. (Author) 23 refs.

  7. Analysis of fetal dose in CT procedures; Analisis de dosis fetal en procedimientos de tomografia computarizada

    Energy Technology Data Exchange (ETDEWEB)

    Ortiz Torres, A.; Plazas, M. C.

    2006-07-01

    It is the miracle of the life, that sublime formation, the given more beautiful gift for heaven's sake to our to exist, and it is consequently our responsibility to look after their protection and care. Today in day the quantity of radiation absorbed by the fetus in the treatments for radiodiagnostic, mainly in the procedures of on-line axial tomography, the fetus absorbs a considerable dose of radiation and the questions generated regarding if these doses, bear to a risk of malformations or if it is necessary the interruption of the pregnancy is very frequent. In most of the cases, the treatment with ionizing radiations that it is beneficial for the mother, is only indirectly it for the fetus that is exposed to a risk. The possibility that a fetus or a small boy contract cancer caused by the radiation it can be three times superior to that of the population in general, of there the importance of analyzing the goods of the prenatal irradiation and the main agents to consider for the estimate of the magnitude of the risk of the exhibitions in uterus. In the different circumstances in that these can happen in treatments of on-line axial tomography computerized. (Author)

  8. Modelos compartimentales para el cálculo de dosis interna

    OpenAIRE

    Sofia Carlos Alberola; Sergio Gallardo Bermell; Sebastián Martorell Alsina

    2013-01-01

    Dosimetría de la Radiación is a subject to be coursed in the Master de Seguridad Industrial y Medioambiente. One of the main objectives of this subject is to provide the appropriate tools to the students for the estimation of external and internal dose. The course is organized with many practical sessions, in which the students use calculation tools to estimate the dose produced by diferent exposure pathways. One of the problems proposed is to determine the dose received in the thyroid by the...

  9. Penentuan Dosis Insektisida Nabati Ekstrak Air Daun Pepaya (Carica papaya L.) Terhadap Larva Buah Jeruk

    OpenAIRE

    Ratna

    2016-01-01

    Background: The use ofsynthetic insecticides on an ongoing basis can have a negative impact on human health and the environment. Required control alternative. Papaya leaves(Carica papaya L.)can be developedas aninsecticide active ingredient vegetable contains the enzyme papain, alkaloids, flavonoids, polyphenols, quinones, and terpenoids. Purpose: determine the effectof water extract papaya leaves mortality on larvae citrus fruit and Effective doses of water extract papaya leaves right as ...

  10. Pertumbuhan dan Hasil Tiga Varietas Ubi Jalar (Ipomoea batatas L.) pada Berbagai Dosis Pupuk anorganik

    OpenAIRE

    Hasibuan, Dewi Sartika

    2011-01-01

    Sweet potatoes is stample food by people which produce carbohidrate number fourth after rice, corn, and cassava and contains carotein is more. Cultivar is related by the porpuse. can effect physics, anorganic and biological of soil that can repair growth and product plants. This research is want to know effectivity of anorganic fertilizer to growth and production of sweet potatoes. This research was held in practice field of Cengkeh Turi, Binjai from Desember to February 201...

  11. Dose estimation by biological methods; Estimacion de dosis por metodos biologicos

    Energy Technology Data Exchange (ETDEWEB)

    Guerrero C, C.; David C, L.; Serment G, J.; Brena V, M. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    1997-07-01

    The human being is exposed to strong artificial radiation sources, mainly of two forms: the first is referred to the occupationally exposed personnel (POE) and the second, to the persons that require radiological treatment. A third form less common is by accidents. In all these conditions it is very important to estimate the absorbed dose. The classical biological dosimetry is based in the dicentric analysis. The present work is part of researches to the process to validate the In situ Fluorescent hybridation (FISH) technique which allows to analyse the aberrations on the chromosomes. (Author)

  12. ANALISIS KEROPOS PADA PENGELASAN LASER MIKRO KAPSUL TERAPI KANKER LAJU DOSIS RENDAH

    Directory of Open Access Journals (Sweden)

    DK Yoga

    2014-06-01

    Full Text Available Salah satu terapi pengobatan kanker adalah dengan menggunakan radioaktif yang dimasukkan ke dalam mikrokapsul untuk diimplan ke dalam jaringan tubuh pasien yang terkena kanker.  Mikrokapsul terbuat dari bahan Ti6Al4V ditutup menggunakan las laser. Pada saat pengelasan terjadi proses perubahan fase padat ke cair dan sebaliknya. Proses pendinginan dalam pengelasan yang terlalu cepat dapat menyebabkan keropos karena adanya gas yang terjebak pada saat pemadatan.  Waktu pencairan dan pemadatan pada pengelasan laser dipengaruhi oleh pulsa berkas laser dan aliran gas selubung .  Pada penelitian ini digunakan las laser Nd-YAG dengan bentuk pulsa trapezium pada frekuensi 5 Hz ,pada daya 300 W dan 400 W serta variasi aliran gas selubung 20,18,15 dan 12 l/min. Hasil pengelasan setelah dibelah dan diamati menggunakan mikroskop stereo ditemukan adanya lobang keropos pada sampel las dengan aliran gas 20 l/min dan efisiensi energy laser turun dengan penambahan panjang durasi pulsa laser pada fase pendinginan.  Untuk mencegah adanya keropos, pengelasan efektif menggunakan aliran gas 15 l/min.  Microcapsules containing radioisotope is one of methods used for cancer treatment. It is put in the microcapsule to be implanted to the body tissues of patient who is affected by cancer. The microcapsule was made of Ti6Al4V and sealed by using laser welding. A phase change from solid to liquid or vice versa occurred during the welding process. A fast cooling time in welding process can cause a loss of porosity due to a gas entrapment during solidification. The melting and solidification time of laser welding were affected by laser beam pulse and the flow of sealed gas. In this study, Nd-YAG laser was used in a shape of trapezium pulse. The study was carried out with a frequency, power and sealed gas flow of 5Hz, 300 and 400 W, and 20, 18, 15, 12 l/min, respectively. The welding product after splitting was further observed using a stereo microscope. The result revealed that a porous hole was found in welding samples in a gas flow of 20 l/min and a decrease of laser energy exist by the increasing of long duration laser pulses in cooling time. Laser welding process was also found to be effective in gas flow of 15 l/min.

  13. Fractionated radiosurgery for painful spinal metastases: DOSIS - a phase II trial

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    Guckenberger Matthias

    2012-11-01

    Full Text Available Abstract Background One third of all cancer patients will develop bone metastases and the vertebral column is involved in approximately 70% of these patients. Conventional radiotherapy with of 1–10 fractions and total doses of 8-30 Gy is the current standard for painful vertebral metastases; however, the median pain response is short with 3–6 months and local tumor control is limited with these rather low irradiation doses. Recent advances in radiotherapy technology – intensity modulated radiotherapy for generation of highly conformal dose distributions and image-guidance for precise treatment delivery – have made dose-escalated radiosurgery of spinal metastases possible and early results of pain and local tumor control are promising. The current study will investigate efficacy and safety of radiosurgery for painful vertebral metastases and three characteristics will distinguish this study. 1 A prognostic score for overall survival will be used for selection of patients with longer life expectancy to allow for analysis of long-term efficacy and safety. 2 Fractionated radiosurgery will be performed with the number of treatment fractions adjusted to either good (10 fractions or intermediate (5 fractions life expectancy. Fractionation will allow inclusion of tumors immediately abutting the spinal cord due to higher biological effective doses at the tumor - spinal cord interface compared to single fraction treatment. 3 Dose intensification will be performed in the involved parts of the vertebrae only, while uninvolved parts are treated with conventional doses using the simultaneous integrated boost concept. Methods / Design It is the study hypothesis that hypo-fractionated image-guided radiosurgery significantly improves pain relief compared to historic data of conventionally fractionated radiotherapy. Primary endpoint is pain response 3 months after radiosurgery, which is defined as pain reduction of ≥ 2 points at the treated vertebral site on the 0 to 10 Visual Analogue Scale. 60 patients will be included into this two-centre phase II trial. Conclusions Results of this study will refine the methods of patient selection, target volume definition, treatment planning and delivery as well as quality assurance for radiosurgery. It is the intention of this study to form the basis for a future randomized controlled trial comparing conventional radiotherapy with fractionated radiosurgery for palliation of painful vertebral metastases. Trial registration ClinicalTrials.gov Identifier: NCT01594892

  14. Dose in thorax X-ray; Dosis en radiografia de torax

    Energy Technology Data Exchange (ETDEWEB)

    Pinedo S, A.; Hernandez O, M.; Duran M, H. A.; Gonzalez G, R.; Guerra M, J. A.; Hernandez D, V. M.; Salas L, M. A.; Vega C, H. R. [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Calle Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas (Mexico); Rivera M, T. [IPN, Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada, Av. Legaria 694, 11500 Mexico D. F. (Mexico); Azorin N, J. [Universidad Autonoma Metropolitana, Unidad Iztapalapa, Av. San Rafael Atlixco 186, 09340 Mexico D. F. (Mexico)], e-mail: lare_56@hotmail.com

    2009-10-15

    The entrance dose that a patient receives during a radiological study of thorax was measured, these measures were realized with thermoluminescent dosemeters of CaSO{sub 4}:Dy, placed in paraffin phantom. The radiation control in diagnostic radiology should be an important element during each radiological procedure. Current studies suggest that even low dose of X-rays used in routine diagnostic procedures can give space to a small incidence of latent damaging effects in patient. The irradiation of thoracic region is more studied through the conventional radiology, method that continues occupying the first place like diagnostic in several pathologies it generates images of heart, lungs, spine, etc. As well as, allow to observe the location of catheters, subclavian s, nasogastric sound, endotracheal tubes and umbilical catheters. The dose magnitude that is received during the realization of this study type is not usually measured, since the main concern is to have a good image to make a good diagnostic. The measures were realized using equipment parameters that were defined on experience of radiologist technician. The work was realized in the living room 1 of X-rays service of General Hospital of Zone No. 1 of IMSS in Zacatecas. The obtained results demonstrated that irradiation field is not uniform and that in any point where the dose was measured it is not exceeded to that established by the Mexican Official Standard-157-SSA-1996 for a study of thorax X-ray. (Author)

  15. Crystalline dose of interventional radiologists; Dosis en cristalino de radiologicos intervencionistas

    Energy Technology Data Exchange (ETDEWEB)

    Hernandez Concepcion, E.; Diaz Romero, F.; Catalan Acosta, A.; Hernandez Armas, J.

    2013-07-01

    The measured dose area product in radiology equipment used in angio radiology during different diagnostic and therapeutic can be used to estimate the value of the dose in the lens of doctors or medical personnel carrying out such interventions. (Author)

  16. Respuesta de ecotipos de Stylosanthes capitata a dosis de cobre en solución nutritiva

    Directory of Open Access Journals (Sweden)

    Pizarro Esteban A.

    1986-09-01

    Full Text Available La solución nutritiva de Arnon y Hoagland se modificó a 1/10 para simular las condiciones de acidez y fertilidad del suelo de las sabanas bien drenadas isohipertérmicas de los Llanos Orientales de Colombia. Se usaron seis concentraciones de cobre (0,0.05, 0.1, 0.2, 0.4 Y 0.8 ppm. la solución nutritiva se renovó cada 15 días y se aplicaron nitrógeno (14 ppm/semana e hierro (1 ppm, 3/semana. La cantidad de materia seca producida por los ecotipos y el cultivar Capica en los tratamientos de 0.2, 0.4 Y0.8 ppm Cu, fue relativamente te nula. La producción de materia seca de la parte aérea, raíz y total de la planta fue diferente en los ecotipos de S capitata. Así mismo hubo diferencias significativas en la concentración, absorción y translocación del cobre por lo ecotipos y el cultivar Capica. El requerimiento diferencial de cobre, manifestado en la producción de materia seca en la parte aérea en el nivel 0.05 ppr por los ecotipos CIAT 1693 y 1728 por el cultivar Capica (CIAT 102801, se define como el resultado de las relaciones evolutivas de cada ecotipo con el nivel de cobre disponible en la solución del suelo.In the greenhouse ecotypes of Stylosanthes capitata were cultivated to observe their behavior under different copper concentrations. A nutrient solution based on Arnon and Hoagland's (1/10 was used to simulate the acidity and the fertility of well drained savannas of the Eastern Planes of Colombia. Six concentrations of copper were used (O, 0.05, 0.1, 0.2, 0.4 and 0.8 ppm with rewal of the nutrient solution every 15 days, and applications of nitrogen (14 ppm/week and iron (1 ppm, three times/week. The dry matter quantity produced by the ecotypes and the Capica cultivar under treatments of 0.2, 0.4 and 0.8 ppm Cu, relatively nill. A differential behavior of Stylosanthes capitata ecotypes responses to applied copper was observed in relation to dry matter production in aerial, part, root and total plant. So, there were significant differences on the concentration, absorption and translocation of this element by these ecotypes and the Capica cultivar. The differential copper requirements, manifest by the dry matter produced in the aerial part by CIAT 1693,CIAT 1728, and cv. Capica (CIAT 10280 in the 0.05 ppm treatment, seems to be the product of specific evolutional relations of each ecotype with the available copper level in the soil.

  17. Dose evaluation in diagnostic for computerized tomography; Evaluacion de dosis en diagnostico por tomografia computarizada

    Energy Technology Data Exchange (ETDEWEB)

    Flores, W.; Borges, J.C.; Mota, H. [Universidad Federal de Rio de Janeiro, PEN/COPPE/UFRJ. Caixa Postal 68509. 21945-970 Rio de Janeiro (Brazil)

    1998-12-31

    The patients which are subjected to computerized tomography tests are exposed to relatively high doses given as result doses on organs that are not matter to test. It was realized a dose levels raising in patients subjected to tests by T C, utilizing to measure this magnitude, TLD-100 thermoluminescent dosemeters which were put directly on the patient, in eye regions, thyroid, breast and navel; founding doses fluctuating between 29.10-49.39 mGy in organs examined and dose values between 0.21-29.10 mGy for organs that no matter to test. The applications of ionizing radiations in medicine do not have dose limits, but paying attention to the radiological protection optimization principle, it is recommended the use of clothes to anti-rays protection for zones not examined, getting with this to reduce the level doses as low as possible, without this to diminish the test quality. (Author)

  18. TINGKAT KESEMBUHAN TB PARU PADA ANAK BALITA YANG MENDAPAT SUPLEMENTASI VITAMIN A DOSIS TINGGI

    Directory of Open Access Journals (Sweden)

    Susi S. Suwardi

    2012-11-01

    Full Text Available THE RECOVERY RATE OF PULMONARY TUBERCULOSIS OF THE UNDERFIVE CHILDREN SUPPLEMENTED BY HIGHDOSE VITAMIN A.Background: Tuberculosis (TB is the most common cause of death among other Infection disease. It Is recognized thattuberculosis affects various age groups, Including underfive children. The complete and fast treatments are needed to reduce the prevalence and Incidence of TB in the communities. Considering the role of vitamin A In reducing the severely of Infection, supplementation of hlghdose (200.000 IU vitamin A in every two months for 6 months will be helpful to increase recovery rate of pulmonary tuberculosis.Design: This study was conducted at the hospital in Bogor region. Sample size was 66 children of underfive years old, whowere suffered pulmonary TB according to Mantoux test, clinical examination, and chest x-ray (CXR. Physical examination, morbidity, and anthropometric data were assessed every month. Food consumption recall, serum vitamin A concentration, hemoglobin content, hematocrit, blood sedimen rate (BSR, and CXR were assessed at 0 and 6 months. The children wererandomly assigned to either vitamin A-supplemented (AS, n=33 group or vitamin A-unsupplemented (AUS, n=37. All of the children were treated by isoniazide, ethambutol and rifampicin. The recovery rate was assessed according to the score of 3 variabels: nutrition status, BSR, and CXR.Results: Nutrition status and hemoglobin increased significantly in both groups (p<0,05. The clinical symptoms subsided and BSR decreased in both groups, but was not significant different between groups. The CXR data showed there were improvement in 84,5% of AS group and 67,7% of AUS group. There were scoring improvement of the recovery rate in bothgroups, but was not significant different between groups.Conclusions: There was significant relation between vitamin A status and the recovery rate of pulmonary tuberculosis, but was not significant different between groups.Keywords: tuberculosis, vitamin A supplementation, recovery rate

  19. Geometrical Comparison Measures for Tumor Delineation, what do they mean for the Actual Dosis Plan?

    DEFF Research Database (Denmark)

    Hollensen, Christian; Persson, G.; Højgaard, L.;

    2012-01-01

    Purpose/Objective: Gross tumour volume (GTV) delineation is central for radiotherapy planning. It provides the basis of the clinical target volume and finally the planning target volume (PTV) which is used for dose optimization. GTV delineations are prone to intermethod and interobserver variat...

  20. Karakteristik Umbi Dan Pati Dua Varietas Ubi Jalar Pada Berbagai Dosis Pupuk Kalium

    OpenAIRE

    Wissalini

    2011-01-01

    The research was conducted to find the effectof varieties and potassium fertilizer on the characterization of sweet potato and its starch. This research was performed in November 2010-September 2011 at the Laboratory of Food Technology, Agriculture Faculty, North Sumatera University, Medan and The Laboratory of Chemistry TechnicBogor Institute of Agriculture, using randomized block factorial design with two steps. The first, was planting two varieties of sweet potatoes (Sari and Beta-2) at fo...

  1. Bulløs reaktion efter applikation af en enkelt dosis ingenolmebutat

    DEFF Research Database (Denmark)

    Salskov-Iversen, Marie Luise; Lorentzen, Henrik F

    2013-01-01

    Picato (ingenol mebutate) was recently marketed for local treatment of actinic keratosis (AK). Compared to alternative creams and gels, Picato is a quick and efficient treatment, which is applied for only two to three days. A patient developed a bullous reaction to the gel after a single applicat...... application. Picato 150 microg/g was applied in the evening to AK in the patient's forehead. The patient experienced a headache during the night, and the next morning big, thin-walled bullae had developed in the treated area.......Picato (ingenol mebutate) was recently marketed for local treatment of actinic keratosis (AK). Compared to alternative creams and gels, Picato is a quick and efficient treatment, which is applied for only two to three days. A patient developed a bullous reaction to the gel after a single...

  2. Respons Dosis Biotip Eleusine indica Resisten-Glifosat terhadap Glifosat, Parakuat, dan Glufosinat

    OpenAIRE

    Lubis, Lia Andayani

    2013-01-01

    LIA ANDAYANI LUBIS: Dose Response of Eleusine indica Biotype Glyphosate-Resistance to Glyphosate, Paraquat, and Glufosinate, supervised by Edison Purba and Rosita Sipayung. Goosegrass (Eleusine indica) is one of weeds commonly found in oil palm plantation of which is getting more difficult to control with glyphosate during the last few years in Adolina Estate, PTPN IV. This study aims to determine the dose response of the putative resistant population to three herbicides, glyphosate, para...

  3. PERAN ASOSIASI Synechococcus sp. TERHADAP PROTEIN DAN PRODUKSI BIJI TANAMAN KEDELAI PADA BERBAGAI DOSIS BOKASHI

    OpenAIRE

    Abadi Darma Setia; Raden Soedradjad; Anang Syamsunihar

    2013-01-01

    [ENGLSIH]Seed of soybean is known contained proteins that are good to consume. Soybean is able to live in mutualistic symbiosis with Rhizobium bacteria and non-symbiotic association with photosynthetic bacteria of Synechococcus sp. This bacteria can be a biofertilizer for plants even in unfavorable environmental conditions these bacteria can still contribute nutrients N from N2 fixation in the air. The conducted research aims to study substance of seed protein, and also the plant productions...

  4. PENGARUH JENIS DAN DOSIS PUPUK KANDANG TERHADAP PERTUMBUHAN DAN PRODUKSI JAGUNG MANIS (Zea mays saccharata Sturt

    Directory of Open Access Journals (Sweden)

    A.A.A.S. Trisnadewi

    2011-08-01

    Full Text Available The experiment that aimed to study the types and various levels of manure for improving growth and production of sweet corn was conducted for 9 weeks. Completely randomized design (CRD arranged with nested model was used in this experiment. The main plot consisted of three kind of manures, there were broiler manure (A, horse manure (K, and pig manure (B. As sub plot were levels of manure: without manure D0 (0 ton/ha, D1 (10 ton/ha = 87.51 g/pot, D2 (20 ton/ha = 175 g/pot, D3 (30 ton/ha = 262.5 g/pot, with three replication in each combination treatment. Variables measured in this experiment were plant high, stem diameter, fresh and dry weight of leaf, stem and maize-ear of corn, total dry weight of forage production (stem + leaf and dry weight ratio of stem and leaf of sweet corn. The result of the experiment showed that the effect of broiler, horse, and pig manure on all variables which measured in the experiment were not significantly different (P>0,05. The highest growth and production of sweet corn were obtained at 20 ton/ha level for all kind of manures that used in this experiment with total dry weight of forage production 48.88; 51.11; and 48.30 g/pot and dry weight of maize-ear production 23.80; 23.30 and 22.00 g/pot for broiler, horse and pig manure respectively. Based on results of the experiment it can be concluded that no different effect on type of manure (broiler, horse and pig to the growth and production of sweet corn and the using manure at 20 ton/ha level give the highest growth and production of sweet corn.

  5. EVALUASI SEROLOGIS DARI IMUNISASI PERTUSSIS DENGAN VAKSIN DPT 2 DAN 3 DOSIS

    Directory of Open Access Journals (Sweden)

    Muljati Prijanto

    2012-09-01

    Full Text Available The objective of this study is to evaluate the serological response against pertussis after completion of both 2 and 3 doses of DPT vaccination. The study has been carried out retrospectively among 766 children under 3 years of age in Tulang-an District, Sidoarjo, East Java. The antibody titres against pertussis were measured by micro agglutination test. The results showed that the percentage of children having antibody titre of 1 : 80 or more, at 1—5 months post vaccination were 80.9% and 88.3% for 2 and 3 doses, respectively. The results do not differ significantly. This insignificance was maintained up to 17 months of the post-vaccination period.

  6. Geometrical Comparison Measures for Tumor Delineation, what do they mean for the Actual Dosis Plan?

    DEFF Research Database (Denmark)

    Hollensen, Christian; Persson, G.; Højgaard, L.; Specht, L.; Larsen, Rasmus

    the PTV divided volume of the GTV used to create the PTV. The Pearson correlation between the GVCMs and their corresponding difference in V90 and D90 was calculated and their statistical difference from zero and each other was tested with a ttest with a pvalue of 0.05. Results: The V90 and D90 were...... plane for one patient. GTV contours in white. 150 estimations of the difference between the volumes were calculated for each of the GVCMs. The correlation results can be seen in the table. Table: Correlation coefficients Correlation of V90 Correlation of D90 Dice Coefficient 0.44 ± 0.10 0.43 ± 0.......10 Mismatch 0.82 ± 0.03 0.71 ± 0.05 Volume difference 0.37 ± 0.10 0.32 ± 0.10 Center of mass distance 0.37 ± 0.09 0.49 ± 0.08 Hausdorff distance 0.37 ± 0.10 0.37 ± 0.10 All the correlation coefficients were found significantly different from 0. The correlation coefficient for mismatch was significantly...

  7. Pertumbuhan Awal Mahkota Dewa (Phaleriamacrocarpa pada Beberapa Dosis Vermikomposdan Intensitas Naungan

    Directory of Open Access Journals (Sweden)

    MERAKATI HANDAJANINGSIH

    2015-09-01

    Full Text Available Early Growth of Phaleria macrocarpaunder Different Shade Intensity and Doses ofVermicompost. Phaleria macrocarpaisshade plant,nativeto Papua-Indonesia. This is one of themost valuable herbal plants in Indonesia and widely grown in home gardens as well as in industrialareas.Organic matter incorporated into the media can increase nutrient availability, medium moisture,plant growth regulator, and improve soil structure to support root growth. In addition, light intensity isanother factor determined the optimum growth especially on shade plants. The research was aimed tofind the most appropriate dose and shade intensity to support early growth stage of Phaleriamacrocarpa.CompletelyRandomized Design was applied in Split Plot arrangement with threereplications. The shade intensity consisted of 0, 25, 50, or 75% while the dose of vermicompostconsisted of 0, 300, 600, or 900 g polybag-1. Research showed thatno interaction was revealed betweenshade intensity and dose of vermicompost on plant height, plant fresh weight and degree of leaf greeness.Root length and root dry weight responded linierly under 25, 50, and 75% shadesThere was no responseon plant growth with the increase ofdose of vermicompost when plants were grown without shading.The highest growth as shown on leaf number, leaf area, stem diameter, and root growth was under 50%shading and application 900 g polybag-1 of vermicompost. This research thus supports the previousreport that P. macrocarpa is less tolerance to full sunlight during its early growth.

  8. Dose determination in computed tomography; Determinacion de dosis en tomografia computada

    Energy Technology Data Exchange (ETDEWEB)

    Descamps, C.; Garrigo, E.; Venencia, D. [Fundacion Marie Curie, Instituto Privado de Radioterapia, Departamento de Fisica Medica, Obispo Oro 423, X5000BFI Cordoba (Argentina); Gonzalez, M. [Universidad Nacional de Cordoba, Facultad de Ciencias Exactas, Fisicas y Naturales, Av. Velez Sarsfield 299, Corboba (Argentina); Germanier, A., E-mail: agermani@ceprocor.uncor.edu [Ministerio de Ciencia y Tecnologia, Ceprocor, Alvarez de Arenas 230, X5004AAP Barrio Juniors, Cordoba (Argentina)

    2011-10-15

    In the last years the methodologies to determine the dose in computed tomography have been revised. In this work was realized a dosimetric study about the exploration protocols used for simulation of radiotherapy treatments. The methodology described in the Report No. 111 of the American Association of Medical Physiques on a computed tomograph of two cuts was applied. A cylindrical phantom of water was used with dimensions: 30 cm of diameter and 50 cm of longitude that simulates the absorption and dispersion conditions of a mature body of size average. The doses were determined with ionization chamber and thermoluminescent dosimetry. The results indicate that the dose information that provides the tomograph underestimates the dose between 32 and 35%.

  9. Pengembangan dan Uji Kinerja Mesin Pemupuk Dosis Variabel pada Budidaya Padi Sawah dengan Konsep Presisi

    Directory of Open Access Journals (Sweden)

    Pandu Gunawan

    2013-04-01

    Full Text Available This paper discussed about the development of electronically controlled fertilizer applicator machine based on modified riding type paddy transplanter tractor. The machine had ability to perform variable rate of application dose using urea, phosphor, and NPK compound. The developed variable rate applicator (VRA equipped with digital controlled metering devices so that the dose of application can be given accurately and the amount of application can be change in flexible way according to recommended dose. The machine has 4 unit of metering devices, has 8 application rows, and equipped with pneumatic diffusers. RTK-DGPS was used to monitor the position in the field. Performance test has been done for several parameters, included uniformity of air flow at each diffuser, granular fertilizer spreader pattern, and linearity of actual amount of fertilizer with respect to the commanded dose. Average rate of air flow in each diffuser was 0.0073 m3/s, with 7.23 % CV. Total working width of the machine was about 5 m. Field capacity was about 0.12 ha/hours. The results of the tests on metering dose showed that the develop VRA could spread fertilizer uniformly and gave accurate application dose. The yield result showed that uniformity of unhulled rice production was reached 74.7%.

  10. Dose and Dose-Rate Effectiveness Factor (DDREF); Der Dosis- und Dosisleistungs-Effektivitaetsfaktor (DDREF)

    Energy Technology Data Exchange (ETDEWEB)

    Breckow, Joachim [Fachhochschule Giessen-Friedberg, Giessen (Germany). Inst. fuer Medizinische Physik und Strahlenschutz

    2016-08-01

    For practical radiation protection purposes it is supposed that stochastic radiation effects a determined by a proportional dose relation (LNT). Radiobiological and radiation epidemiological studies indicated that in the low dose range a dependence on dose rates might exist. This would trigger an overestimation of radiation risks based on the LNT model. OCRP had recommended a concept to combine all effects in a single factor DDREF (dose and dose-Rate effectiveness factor). There is still too low information on cellular mechanisms of low dose irradiation including possible repair and other processes. The Strahlenschutzkommission cannot identify a sufficient scientific justification for DDREF and recommends an adaption to the actual state of science.

  11. Modelos compartimentales para el cálculo de dosis interna

    Directory of Open Access Journals (Sweden)

    Sofia Carlos Alberola

    2013-06-01

    Full Text Available Dosimetría de la Radiación is a subject to be coursed in the Master de Seguridad Industrial y Medioambiente. One of the main objectives of this subject is to provide the appropriate tools to the students for the estimation of external and internal dose. The course is organized with many practical sessions, in which the students use calculation tools to estimate the dose produced by diferent exposure pathways. One of the problems proposed is to determine the dose received in the thyroid by the inhalation of a certain amount of Iodine-131. In this case, the International Commission on Radiological Protection, has published two guides to estimate the transfer of radionuclides inside the human respiratory tract and the thyroid. Both estimations are obtained using biokinetic models, in which each organ is considered as a compartment and a mass balance is performed for each compartment. So the dose in a certain organ can be estimated by solving a system of differential equations with constants coefficients, what can be done using MatLab©.

  12. Pengembangan Sistem Aquisisi Data Kadar Nitrogen Tanah Berbasis Sensor Infra Merah Sebagai Pedoman Penentuan Dosis Pemupukan

    Directory of Open Access Journals (Sweden)

    Abdul Roni Angkat

    2011-10-01

    Full Text Available Site specific nitrogen fertilizing needs an accurate map of soil nitrogen content. The use of sensors operated upon the soil is a promising method since the accurate soil sampling methods are costly and time consuming. The objectives of this research are to determine the relation between soil nitrogen level and near infrared spectrum using artificial neural network (ANN and to develop soil nitrogen content data acquisition system for static dan dynamic measurement. The results showed that the 1506 nm wavelength can be used to estimate the soil nitrogen content. Furthermore it was found that static measurement showed a better correlation (R2= 0.6286 than the dynamic measurement (R2=0.3111. Combined with the developed ATMega32 microcontroller based display recorder, the precision of N content measurement achieved 0.12% wb with 0.1% wb noise.

  13. Respon Imun Itik Bali terhadap Berbagai Dosis Vaksin Avian Influenza H5N1

    Directory of Open Access Journals (Sweden)

    Ida Bagus Kade Suardana

    2009-09-01

    Full Text Available A study was carried out to investigate the immune response of Bali ducks against various doses ofAvian Influenza H5N1 vaccine. The study was carried out using a complete Random-Split in Time researchdesign as many as 40 of Bali ducks of 3 months age were kept separately in 4 groups. The ducks werevaccinated twice in two week interval with AI H5N1 vaccine of 0 (as negative control, 1/2, 1, and 2 doses.Sera were collected one day before first vaccination, then every week until three weeks after the secondvaccination. All sera were tested by hemaglutination inhibition (HI test. The result shows that antibodylevel with double dose was significantly higher than single dose, half dose, and negative control (P<0.01.However antibody level in ducks vaccinated with single and half dose did not show any significant difference(P > 0.05.

  14. UJI PENAMBAHAN BERBAGAI DOSIS VERMIKOMPOS TERHADAP PERTUMBUHAN VEGETATIF CABAI MERAH BESAR Capsicum annuum L.

    OpenAIRE

    Zohra Hasyim; Elis Tambaru; Andi Ilham Latunra

    2015-01-01

    This research entitled " Effect of Vermicompost on growth of Capsicum annuum Chilli Red Big L. " . Is aimed to determine the effect of vermicompost on the growth of vegetative big red chili . Planting medium used is consisted of soil and vermicompost . Vermicompost derived from the cultivation of earthworms Lumbricus rubellus . Large red chilli seeds purchased from the farm shop . Large red chilli seeds germinated in vermicompost mixed soil and covered with clear plastic . This study is an ex...

  15. Respons Pertumbuhan dan Produksi Ubi Jalar Terhadap Pemberian Berbagai Kombinasi Dosis Pupuk Organik dan Anorganik.

    OpenAIRE

    Dwi Arga, Meilisya

    2011-01-01

    The usage of inorganic fertilizers (chemical fertilizers) in the long run lead to decreased soil organic matter content, soil structure is damaged, and environmental pollution. To maintain and enhance soil productivity necessary combination of inorganic fertilizers with organic fertilizers precisely. This study aims to determine the growth and production of sweet potato (Ipomea batatas L.) as a result of various doses of organic and inorganic fertilizers. The research was co...

  16. Analyse der Dosis-Wirkungsbeziehung einfacher und kombinierter Obliquusoperationen zur Behandlung des einseitigen Strabismus sursoadductorius

    OpenAIRE

    von Hundelshausen, Anna

    2012-01-01

    Aim of this retrospective study was to analyse the dose-response relationship of verticaldeviation and excyclodeviation and the length of inferior oblique muscle recession and combined superior oblique muscle tucking at patients with unilateral Strabismus sursoadductorius. Contrary to the three step graduation of other studies in this study the length of the recession or tucking of the muscles were adopted individually to the preoperative Verticaldeviation. In inferior oblique muscle recessio...

  17. Kinetic changes in activity of HR-peroxidase, induced by very low doses of phenol Cambios cinéticos en la actividad de la HR-peroxidasa inducidos por dosis muy bajas de fenol Mudanças cinéticas na atividade da HR-peroxidade induzidas por doses muito baixas de fenol

    Directory of Open Access Journals (Sweden)

    Elzbieta Malarczyk

    2008-06-01

    sistemático através de métodos colorimétricos e luminométricos. Os resultados mostram que as diluições de fenol, incluindo aquelas por baixo do número de Avogadro, foram capazes de ativar ou inibir a HRP em reações de tipo peroxidade e oxidase com um padrão sinusoidal. os valores Km dos substratos estudados variaram paralelamente à atividade peroxidase/oxidase da HRP; a atividade máxima da reação peroxidase correspondeu à atividade mínima na reação oxidase e vice-versa. O efeito também se mostrou dependente do tipo do solvente. A observação das oscilações sinusoidais na atividade da HRP, dependentes da taxa de dissolução do fenol e do tempo de pré-incubação, permitem concluir que a HRP pode ser um bom modelo na pesquisa das altas diluições. Os experimentos oferecem fortes evidências a favor da HRP como detector muito sensível de mudanças mínimas na concentração do fenol, utilizado como cofator na reação peroxidase/oxigenase. Palavras-chave: HR-peroxidase, peroxidase-oxidase, fenol, hormese, homeopatia, altas diluições.   Cambios cinéticos en la actividad de la HR-peroxidasa inducidos por dosis muy bajas de fenol Resumen La proteína alostérica de la peroxidasa del rábano (HRP muestra dos tipos principales de actividad, peroxidasa y oxidasa, dependiendo del tipo de efectores de baja molecularidade. Los efectos de doses muy bajas de fenol, preparadas mediante diluciones sucesivas en agua o etanol al 75% sobre la actividad inicial de la HRP sobre la oxidación de o-dianisidina o luminol fueron testados de modo sistemático mediante métodos colorimétricos y luminométricos. Los resultados muestran que las diluciones de fenol

  18. Avaliação do estado ácido-básico materno com o uso de sufentanil por via subaracnóidea em diferentes doses para cesarianas e suas repercussões sobre os recém-nascidos Evaluación del estado ácido-básico materno con el uso de sufentanil por vía subaracnóidea en diferentes dosis para cesáreas y sus repercusiones sobre los recién nacidos Evaluation of maternal acid-base status after different doses of spinal sufentanil for cesarean section and its effects on the neonates

    Directory of Open Access Journals (Sweden)

    Luís Fernando Lima Castro

    2003-02-01

    efecto colateral más grave la depresión respiratoria. Se objetivó en este estudio evaluar el estado ácido-básico materno con el uso de sufentanil subaracnóideo en diferentes dosis, asociado a la bupivacaína hiperbárica, para cesáreas y sus repercusiones sobre los recién nacidos. MÉTODO: Fueron evaluadas 40 gestantes a término, estado físico ASA I , con edades entre 17 y 35 años, sometidas a cesárea electiva bajo raquianestesia y divididas en 2 grupos equitativos: en el grupo I recibieron 12 mg de bupivacaína a 0,5% hiperbárica asociados a 2,5 µg de sufentanil y en el grupo II recibieron 12 mg de bupivacaína a 0,5% hiperbárica asociados a 5 µg de sufentanil. Fueron evaluados: estado ácido-básico materno a través de gasometria arterial antes de la realización de la anestesia y después del nacimiento del concepto, SpO2, alteraciones hemodinámicas, vitalidad de los recién nacidos a través del índice de Apgar y gasometria del cordón umbilical y presencia de efectos colaterales. RESULTADOS: Los grupos se mostraron homogéneos en los parámetros evaluados, observándose discreta acidosis metabólica materna compensada en ambos grupos tanto antes de la realización de la anestesia como luego después del nacimiento del concepto, no obstante, sin repercusiones clínicas. Los recién nacidos presentaron buena vitalidad y gasometrias compatibles con la normalidad. CONCLUSIONES: La asociación de bupivacaína hiperbárica en pequeñas dosis de sufentanil subaracnóideo en cesáreas mostró que es la técnica segura al binomio materno-fetal, preservando su estado hemodinámico y ácido-básico.BACKGROUND AND OBJECTIVES: Spinal sufentanil in obstetric anesthesia promotes immediate pain relief, improves anesthesia quality and prolongs postoperative analgesia, its major side effect being respiratory depression. This study aimed at evaluating maternal acid-base status after different doses of spinal sufentanil associated to hyperbaric bupivacaine for

  19. Protocol for thyroid remnant ablation after recombinant TSH in thyroid carcinoma Protocolo para ablación de remanentes tiroideos luego de TSH recombinante en el cáncer diferenciado de tiroides

    Directory of Open Access Journals (Sweden)

    Fabián Pitoia

    2009-02-01

    Full Text Available In some countries, in order to perform rhTSH-aided thyroid remnant ablation (TRA after surgery, it is generally necessary to confirm that thyroidectomy has been almost complete. Otherwise, the nuclear medicine specialist will not administer a high radioiodine dose because it might be hazardous due to the possibility of thyroid remnant actinic thyroiditis. Considering this, it would be necessary to use two rhTSH kits (one for diagnostic purposes and the other one to administer the 131I dose. In this study, we used an alternative protocol for TRA with the use of one kit of rhTSH in twenty patients diagnosed with low risk papillary thyroid carcinoma. All patients had negative titers of anti-thyroglobulin antibodies. Successful thyroid remnant ablation was confirmed with an undetectable rhTSH stimulated thyroglobulin level (En algunos países, para realizar la ablación de los remanentes tiroideos con radioyodo después de la cirugía, generalmente se requiere confirmar que la tiroidectomía fue casi completa, ya que de otra manera el especialista en medicina nuclear no administrará una dosis elevada de radioyodo, considerando que esto puede ser dañino para el paciente debido a la posibilidad de generar una tiroiditis actínica. De acuerdo con esto, sería necesario administrar 2 kits de rhTSH (uno para diagnóstico y otro para la dosis de radioyodo. En este estudio, empleamos un protocolo alternativo para la ablación luego de la administración de un único kit (2 ampollas de rhTSH en 20 pacientes con antecedentes de un carcinoma papilar de bajo riesgo. Todos los pacientes presentaban títulos negativos de anticuerpos anti-tiroglobulina. La ablación exitosa de remanente tiroideo se confirmó con un nivel no detectable de tiroglobulina (<1 ng/ml al estímulo por rhTSH en los 20 pacientes, entre 8 a 12 meses luego de la ablación. El uso de este protocolo que combina la posibilidad de realizar un centellograma diagnóstico y la ablación luego

  20. Adherencia terapéutica y flexibilidad en el uso de las insulinas basales

    Directory of Open Access Journals (Sweden)

    José E Costa Gil

    2014-08-01

    Full Text Available Desde 1921, los beneficios alcanzados por las investigaciones sobre insulinoterapia han sido constantes. Sin embargo, el temor a las hipoglucemias y la rigidez horaria para administrar la insulina aún interfieren sobre la adherencia al tratamiento, que es esencial para lograr un buen control de la glucemia y minimizar las complicaciones en los pacientes con diabetes. En este contexto, se analiza la posibilidad de utilizar un análogo de insulina ultra-lento (degludec que posee un perfil farmacocinético prolongado y predecible por más de 24 horas. En ensayos clínicos demostró que, al administrarlo en un esquema de dosis flexible mantiene un buen control de la glucemia, sin que aumente el riesgo de hipoglucemias. Si bien en la práctica clínica es aconsejable seguir un plan establecido, la posibilidad de flexibilizar el horario en la aplicación diaria del análogo ultra-lento en caso de ser necesario, podría mejorar la adherencia en pacientes con una vida social y laboral activa y poco previsible.

  1. Development of a program for calculation of second dose and securities in brachytherapy high dose rate; Elaboracion de un programa para el segundo calculo de la dosis y seguridades en braquiterapia de alta tasa de dosis

    Energy Technology Data Exchange (ETDEWEB)

    Esteve Sanchez, S.; Martinez Albaladejo, M.; Garcia Fuentes, J. D.; Bejar Navarro, M. J.; Capuz Suarez, B.; Moris de Pablos, R.; Colmenares Fernandez, R.

    2015-07-01

    We assessed the reliability of the program with 80 patients in the usual points of prescription of each pathology. The average error of the calculation points is less than 0.3% in 95% of cases, finding the major differences in the axes of the applicators (maximum error -0.798%). The program has proved effective previously testing him with erroneous dosimetry. Thanks to the implementation of this program is achieved by the calculation of the dose and part of the process of quality assurance program in a few minutes, highlighting the case of HDR prostate due to having a limited time. Having separate data sheet allows each institution to its protocols modify parameters. (Author)

  2. Definición, diseño e implementación de una tecnología y una herramienta que la soporta para manipular, controlar y administrar el flujo de información de sistemas en bloque

    OpenAIRE

    Sanz Barco, Pablo Alberto

    2014-01-01

    Este proyecto consiste en la creación y desarrollo de una herramienta capaz de gestionar el flujo masivo de información proveniente de un operador internacional de telefonía. Las funciones que debe de realizar esta herramienta, son entre otras, facilitar la labor de los usuarios y minimizar tanto el esfuerzo como el tiempo que se emplea para elaborar informes que ayudan a la gestión y toma de decisiones que los usuarios realizan. Para ello, se ha realizado previamente un breve estudio de l...

  3. Dose levels in the hot cells area ININ; Niveles de dosis en el area de celdas calientes-ININ

    Energy Technology Data Exchange (ETDEWEB)

    Torre, J. De la; Ramirez, J.M. [ININ, A.P. 18-1027, 11801 Mexico D.F. (Mexico); Solis, M.L. [UAEM, Toluca, Estado de Mexico (Mexico)]. E-mail: jto@nuclear.inin.mx

    2004-07-01

    The Laboratory of Hot Cells (LCC) located in the National Institute of Nuclear Research (ININ) is an institution, it is an area where radioactive material is managed with different activity values, in function of its original design for 10,000 curies of Co-60. Managing this materials in the installation, it implies to measure and to analyze the dose levels that the POE will receive as well as the implementation of appropriate measures of radiological protection and radiological safety, so that that is completed settled down by the concept ALARA. In this work they are carried out mensurations of the levels of the dose to receive for the POE when managing radionuclides with maximum activities that can be allowed in function of the current conditions of the cells and an evaluation of the obtained results is made comparing them with the effective international norms as well as the application of the program of surveillance and radiological protection implemented for the development of the works that are carry out in the installation. (Author)

  4. Producción de semilla de cacahuate forrajero con siete dosis de cal y tres fechas de cosecha

    OpenAIRE

    Javier Francisco Enríquez Quiroz; Adrián Raymundo Quero Carrillo

    2001-01-01

    Arachis pintoi (cacahuatillo) es una valiosa leguminosa que puede ser utilizada con diferentes propósitos. En México la producción de semilla es nula, así como su manejo. Los objetivos fueron determinar la respuesta a la aplicación de cal y el tiempo a la cosecha de semilla. Se evaluaron dos ecotipos del CIAT (17434 y 18744), siete niveles de cal y tres fechas de cosecha, en un diseño de parcelas divididas; Se registró información de producción de semilla, peso unidad de semilla sin lavar, la...

  5. Pengaruh Waktu Aplikasi Dan Pemberian Berbagai Dosis Kompos Azolla Terhadap Pertumbuhan Dan Produksi Tanaman Kedelai (Glycine Max (L) Merrill)

    OpenAIRE

    Wibowo, Ary

    2011-01-01

    Therefore, a research had been conducted at experimental field of College of Agriculture USU (± 25 m asl.) in March until July 2010 using factorial randomized block design with two factor, i.e. time application of azolla compost (21, 14, 7 day before planted and when planted) and variant doses of azolla compost (0, 2 0, 40, 60 g per plant). Parameters measured were plant’s height, numbers of leaf, numbers productive branch, shoot wet weight, shoot dry weight, root wet weight, root dry weight...

  6. Pemberian Azolla Uutuk Mengurangi Dosis Urea Padi Sawah (Oryza sativa L ) Pada Inseptisol di Silakkidir Kecamatan Hutabayuraja Kabupaten Simalungun

    OpenAIRE

    Purba, Freddy Alfian

    2012-01-01

    Penelitian ini bertujuan untuk melihat pengaruh Azolla dalam menyuplai N pada pertanaman padi sawah {Oryza sativa L ) pada Inseptisol di Silakkidir, Kecamatan Hutabayuraja Simalungun.. Pelaksanaan penelitian ini dilakukan di Desa Silakkidir Kecamatan Hutabayuraja Kabupaten Simalungun. Penelitian ini dimulai dari bulan Juni sampai November 2003. Rancangan yang digunakan adalah rancangan acak kelompok (RAK) Non Faktonal dengan 5 perlakuan dan 3 ulangan, masing- masing perlakuan adalah : F...

  7. Effects of X-rays spectrum on the dose; Efectos del espectro de rayos X sobre la dosis

    Energy Technology Data Exchange (ETDEWEB)

    Rodriguez I, J. L.; Hernandez A, P. L.; Vega C, H. R. [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas (Mexico); Rivera M, T., E-mail: johann_greenday@hotmail.com [IPN, Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada, Av. Legaria No. 694, 11500 Mexico D. F. (Mexico)

    2015-10-15

    The X-ray equipment for diagnosis comes in different sizes and shapes depending on the scan type to perform. The X-ray spectrum is the energy distribution of the beam photons and consists of a continuous spectrum of photons braking and discrete spectrum due to the characteristic photons. The knowledge of the X-rays spectrum is important to understand like they affect the voltage changes (k Vp), current (m A), time (s) and the type of filter in the interaction mechanisms between X-rays and patient's body, the image receptor or other material that gets in the beam. Across the spectrum can be estimated the absorbed dose in any point of the patient, the quality of the image and the scattered radiation (which is related to the dose received by the equipment operator). The Monte Carlo method was used by MCNP5 code to calculate the spectrum of X-rays that occurs when a monoenergetic electron beam of 250 keV interact with targets of Mo, Rh and W. The spectra were calculated with and without filter, and the values of ambient dose equivalent were estimated, as well as the air kerma. (Author)

  8. English; Evaluacion de la dosis efectiva annual debido a fuentes ambientales de radiacion en la Provincia de Holguin, Cuba

    Energy Technology Data Exchange (ETDEWEB)

    Brigido Flores, Osvaldo; Barreras Cabellero, Aldo A.; Montalvan Estrada, Adelmo [Laboratorio de Vigilancia Radiologica Ambiental de Camaguey (Cuba)]. E-mail: sean@caonao.cmw.inf.cu; Hernandez Perez, Alberto; Tamayo, Luis Perez; Parra Valdes, Dermidio; Bravo Lopez, Rosendo [Centro de Atencion a la Actividad Nuclear, Holguin (Cuba); Zerquera, Juan Tomas [Centro de Proteccion y Higiene de las Radiaciones, La Habana (Cuba)

    2001-07-01

    A survey program aiming at studying the natural radioactivity in the Province of Holguin is a part of the national program carried out for 3 years. Radiological measurements carried out with a portable ionization chamber RSS-111 and RSS-112 at the sampled sites revealed an average outdoor absorbed dose rate of 43.5 nGy.h{sup -1} due to cosmic rays and terrestrial gamma radiation. Ratio of indoor to outdoor absorbed dose rates in air was 1.6. The average value of absorbed dose rate in air for the ionizing component of cosmic rays was 31.9 nGy.h{sup -1} at sea level. Because of the 82% of the Holguin population lives at altitudes close to sea level (10-200 m), the absorbed dose rate in outdoor air from ionizing component of cosmic rays was estimated to be 33.8 nGy.h{sup -1}. An annual average effective dose equivalent of 340 {mu}Sv was estimated for Holguin population due to the ionizing component of cosmic and gamma terrestrial radiation. This value is lower the 510 {mu}Sv.year{sup -1} estimated for the Camaguey population and lower than the 760 {mu}Sv.year{sup -1} estimated as a world average by UNSCEAR (1993). (author)

  9. Estimation of effective dose during hysterosalpingography procedures; Estimación de dosis efectiva durante los procedimientos hysterosalpingography

    Energy Technology Data Exchange (ETDEWEB)

    Alzimamil, K.; Babikir, E.; Alkhorayef, M. [King Saud University, College of Applied Medical Sciences, Radiological Sciences Department, P. O. Box 10219, Riyadh 11433, (Saudi Arabia); Sulieman, A. [Salman bin Abdulaziz University, College of Applied Medical Sciences, Radiology and Medical Imaging Department, P. O. Box 422, Alkharj (Saudi Arabia); Alsafi, K. [King Abdulaziz University, Faculty of Medicine, Radiology Department, Jeddah 22254 (Saudi Arabia); Omer, H., E-mail: kalzimami@ksu.edu.sa [Dammam University, Faculty of Medicine, Dammam Khobar Coastal Rd, Khobar 31982 (Saudi Arabia)

    2014-08-15

    Hysterosalpingography (HSG) is the most frequently used diagnostic tool to evaluate the endometrial cavity and fallopian tube by using conventional x-ray or fluoroscopy. Determination of the patient radiation doses values from x-ray examinations provides useful guidance on where best to concentrate efforts on patient dose reduction in order to optimize the protection of the patients. The aims of this study were to measure the patients entrance surface air kerma doses (ESA K), effective doses and to compare practices between different hospitals in Sudan. ESA K were measured for patient using calibrated thermo luminance dosimeters (TLDs, Gr-200A). Effective doses were estimated using National Radiological Protection Board (NRPB) software. This study was conducted in five radiological departments: Two Teaching Hospitals (A and D), two private hospitals (B and C) and one University Hospital (E). The mean ESD was 20.1 mGy, 28.9 mGy, 13.6 mGy, 58.65 mGy, 35.7, 22.4 and 19.6 mGy for hospitals A,B,C,D, and E), respectively. The mean effective dose was 2.4 mSv, 3.5 mSv, 1.6 mSv, 7.1 mSv and 4.3 mSv in the same order. The study showed wide variations in the ESDs with three of the hospitals having values above the internationally reported values. Number of x-ray images, fluoroscopy time, operator skills x-ray machine type and clinical complexity of the procedures were shown to be major contributors to the variations reported. Results demonstrated the need for standardization of technique throughout the hospital. The results also suggest that there is a need to optimize the procedures. Local DRLs were proposed for the entire procedures. (author)

  10. Pengaruh Dosis Pupuk Kotoran Ayam dan Nitrogen terhadapPertumbuhan dan Hasil Sayur Sawi Daging (Brassica rapa L. Varietas Gardena

    Directory of Open Access Journals (Sweden)

    DAVID HARYSUSANTO

    2015-09-01

    Full Text Available The Effects of Various Dose of Chicken Manure and Nitrogen Fertilizer on The Growth and Yield of Mustard (Brassica rapa L. Var. Gardena. The Aim of the research was to find out optimal dose of chicken manure and nitrogen fertilizer and to find out those effects of both fertilizers and their interaction on the growth and yield of mustard. The research was carried out at Candikuning, Baturiti, Tabanan Regency, from April to June 2013. The experiment was factorial (two factors, with randomized block design (RBD. First factor was. chicken manure fertilizer dose, i.e. 0 ton ha-1, 15 ton ha-1 and 30 ton ha-1, while the second factor was nitrogen fertilizer with three levels of dose, i.e. 0 kg ha-1, 92 kg ha-1 and 184 kg ha-1. The result showed that there was no interaction effects of those two factors on all variables observed.. Dose of 15 ton ha-1 chicken manure and 92 kg/ha-1 nitrogen fertilizer resulted in highest yield and highest dry weight of shoots. However, the optimum dose (estimated with regression line was150 kg ha-1 for nitrogen fertilizer and was 25,50 ton ha-1 for chicken manure.

  11. Expert optimum coagulant dose selection system; Sistema experto para la seleccion de la dosis optima de coagulante

    Energy Technology Data Exchange (ETDEWEB)

    Marin Llanes; Alvarez Rossell, S.; Medina, J.; Socorro, R.; Vega, J. [La Habana. Cuba (Cuba)

    1997-09-01

    In this paper the authors present and Expert System for the selection of the alumina optimal doses in a surface water treatment plant for human consumption. The system allows to select the optimal doses by mean of the best qualified technician experience in the plant. Besides, the system can be used to train non-specialists staff. (Author) 6 refs.

  12. State of the art in Europe on dose limit; Situacion actual de la limitacion de dosis en Europa

    Energy Technology Data Exchange (ETDEWEB)

    Munoz, M. J.; Amor, I.

    2002-07-01

    The process of setting up new radiological protection limits and requirements constitutes a long and laborious task, since the definition of the scientific bases that support them until their obliged fulfillment by adoption in national regulations. This paper analyzes the most important news contained in the Directive 96/29/Euratom, that are being transposed into Member States national legislations. Additionally the implications derived from the process are taken into consideration. Certain items as the new dose limits for exposed workers and public, the application of dose constraints, and the requirements for the protection of pregnant women and fetus, were object of special controversy during the development of the directive and they are not being transposed in a common way. So the different approach in the setting up of occupational doses can generate difficulties in the context of the european market. Through the directive constitutes the framework for the radiological protection in the European Union, there are certain difficulties for common implementation that will require subsequent explanations from the Commission and the Competent National Authorities. (Author)

  13. Pengaruh Dosis, Lama Pengendapan Dan Ukuran Partikel Koagulan Serbuk Biji Kelor Sebagai Alternatif Pengolahan Limbah Cair Industri Tahu

    OpenAIRE

    Hutahaean, Rudi Anas

    2015-01-01

    Soyabean (tahu) industrial wastewater contain of many complex organic compounds such as proteins, carbohydrates, fats and oils. Based on the results of Balai Perindustrian Medan research on soyabean industrial wastewater characteristics in Medan, it found that soyabean (tahu) industrial wastewater contain of BOD (4583 mg/l), COD (7050 mg/l), TSS (4743 mg/l ) and oil or fat (26 mg/l ) at pH 6.1. Therefore wastewater treatment is needed to reduce the contaminants contained in ...

  14. Dose around a lineal accelerator of medical use;Dosis en torno a un acelerador lineal de uso medico

    Energy Technology Data Exchange (ETDEWEB)

    Hernandez A, B.; Ortiz H, A.; Hernandez D, V. M.; Vega C, H. R. [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Calle Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas (Mexico); Rivera M, T. [IPN, Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada, Av. Legaria 694, 11500 Mexico D. F. (Mexico); Azorin N, J., E-mail: ice_bere_nice@hotmail.co [Universidad Autonoma Metropolitana, Unidad Iztapalapa, Av. San Rafael Atlixco 186, 09340 Mexico D. F. (Mexico)

    2009-10-15

    By means of a measures series the dosimetric characteristics of the photo neutrons that take place around a lineal accelerator of radiotherapy of 18 MV has been determinate, this it is a linac Varian model 21EX Platinum Plus. The neutron spectrum was established to 100 cm of the isocenter, when it is locates to 10 cm inside an equivalent water phantom. The spectrum was measured with a spectrometric system of Bonner spheres, the used spheres were of 0, 2, 3, 5, 8, 10 and 12 inches of diameter. In the spheres center they were inserted pairs of thermoluminescent dosemeters of the type 600 and 700 as thermal neutrons detector. The due net signal to the neutrons measured with each sphere was used to reconstruct the neutron spectrum; this reconstruction was made with the BUNKIUT code and the response matrix UTA4. The phantom isocenter was exposed at 600 U M and during the irradiation process the rates of environmental equivalent dose were measured by neutrons and photons on the control area of the accelerator. Immediately after having applied the 600 U M the rate of environmental equivalent dose it was measured inside the enclosure and in points around the stretcher due to the neutronic activation. The measured spectrum presents two maxima, one in the thermal neutrons area and the other between 0.1 and 1 MeV, this spectrum is similar to those reported in the literature. The thermal neutrons are produced mainly the {sup r}oom return{sup ,} while the neutrons of approximately 0.5 MeV are those transmitted through the linac head stock. The dose rates in the control area of the accelerator are 3.1 and 0.93 muSv-h{sup -1} for photons and neutrons respectively. Around the stretcher the rates of due dose to the activation photons vary from 6 to 26.1 muSv-h{sup -1}, depending on the measurement place. (Author)

  15. Doses optimization to patients in computed tomography studies; Optimizacion de las dosis a pacientes en estudios de tomografia computada

    Energy Technology Data Exchange (ETDEWEB)

    Trujillo Z, F. E., E-mail: flaviotrujillo@gmail.co [Hospital Regional de Alta Especialidad de Oaxaca, Aldama s/n, Paraje El Tule, 71256 San Bartolo Coyotepec, Oaxaca (Mexico)

    2010-09-15

    in recent years the number of studies of computed tomography has been increased, as well as the technology and methodology of these, while the radiological protection to the patient has not advanced to the same step. The IAEA has implemented the Patients Radiation Protection projects, where one of the areas of more interest is the computed tomography. The present work is a brief summary of the actions to realize for the doses optimization imparted to the patients, obtaining an appropriate diagnostic quality in the images at the same time; as it was presented in the course of the project C-RLA/9/067-001. The results that were obtained between Image Quality and Dose by Radiation that is imparted to the patient are shown, as well s the exposition factors that influence in these, according to the project C-RLA/9/067-001. The main actions for the dose optimization are using tension optimized protocols (kV), of load (m As), of collimation/cut thickness, of inclination of the gantry, of the pitch/displacement by rotation, of the reconstruction algorithm (kernel), according to the diagnostic objective to reach and to the patient physical characteristics (like weight and age), as well as to use protections to shield the sensitive organs (mainly those that do not have clinical interest for the procedure). Conclusion: To establish or to begin to implement, insofar as possible, the IAEA recommendations, relating to the clinical practice of the hospitals in Mexico and to the available equipment s type. (Author)

  16. Measurement of doses to aviator pilots using thermoluminescent dosemeters; Medicion de la dosis a pilotos aviadores usando dosimetros termoluminiscentes

    Energy Technology Data Exchange (ETDEWEB)

    Azorin N, J.; Cruz C, D. [UAM-I, 09340 Mexico D.F. (Mexico); Rivera M, T. [IPN, ESIME Culhuacan (Mexico)]. e-mail: azorin@xanum.uam.mx

    2004-07-01

    During the development of their work, the aviator pilots are exposed at high levels of natural radiation of bottom caused mainly by the cosmic radiation of galactic origin and lot. For such reason, the Metropolitan Autonomous University (UAM) and the Union Association of Aviator Pilots (ASPA), subscribed an agreement with the purpose of to measure the doses of ionizing radiation received by the aviator pilots of diverse air companies that man different types of airships and to determine if these doses surpass the one limit of 0.11 mSv/h settled down by the IAEA for the public in general; and if therefore, these workers should be considered as personnel occupationally exposed. In this work the obtained results when measuring the absorbed dose received by Mexican civil aviator pilots during the development of their work, using thermoluminescent dosemeters of LiF:Mg,Cu,P + Ptfe of national production are presented. The obtained results during the years of 2001 and 2002 show that the monthly doses received by the pilots surpass the one it limits established for the public in general, for what they should be considered as personnel occupationally exposed. (Author)

  17. Dosis loads for temporary workers in decontamination and radiation protection engaged in West German nuclear power plants

    International Nuclear Information System (INIS)

    In the annual inspections of German nuclear power plants a lot of work is done by external specialists, workers and unskilled workers. Data of 1983-1986 have been collected in a decontamination company SInA GmbH Pforzheim. This company did at average 15 power plant inspections, and employed up to 350 coworkers. Decontamination and radiation monitoring are the most important activities. The doses show a continuous decrease over the years. Contrary to expectations the extremely high doses are found with experienced workers. 18 figs. (qui)

  18. Penentuan Dosis Larutan Getah Buah Pepaya (Carica papaya L.) sebagai Pestisida Nabati Terhadap Hama Ulat Tanaman Cabai

    OpenAIRE

    Khairunnisa, Rizki

    2016-01-01

    Introduction: Residues of the chemical pesticide contained in plant will seriously endanger the health of people. According the WHO every year happen about 25 million cases of pesticide poisoning or about 68.493 cases everyday. The use of natural pesticide from plants is one of the solution to overcome negative impact of chemical pesticide. Carica papaya L. has enzyme papain and kimopapain highly on the latex of young fruit use of as proteolytic against caterpillar on plant. This research to ...

  19. RESPON TANAMAN JARAK PAGAR (Jatropha curcas L TERHADAP LIMA DOSIS ZAT PENGATUR TUMBUH (ZPT ASAM NAFTALEN ASETAT (NAA

    Directory of Open Access Journals (Sweden)

    Elda Nurnasari

    2012-03-01

    Full Text Available Productivity improvement of physic nut can be done by the increase of female flowers numbers. Introducing of plant growth regulators (PGR is one of many ways to stimulate flowering. The research was aimed to determine the dose of plant growth regulators NAA (Naphthalene Acetic Acid which can increase the level of production and oil contents. This research was conducted at the Asembagus Experimental for 12 months. Five doses of 500, 1000, 1500, 2000, and 2500 ppm NAA were applied on two years old of J. curcas and arranged in a randomized block design with three replications. For comparison, treatment without PGR was added in treatments. The results showed that NAA application affected the growth plant height, canopy diameter and number of branches and production of fruit numbers, 100-seed weight and oil contents of jatropha. PGR application was able to increase the number of fruit and weight of 100-seed each for 26.64 and 2.07%, respectively, and to reduce the oil contents of 3.05% untreated PGR. Dose of 1000 ppm NAA was able to increase the fruit number and weight of 100-seed each for 35.09 and 2.99%, respectively and reduce the oil contents of 3.58%.

  20. DIAGNÓSTICO NUTRIMENTAL Y VALIDACIÓN DE DOSIS DE FERTILIZACIÓN PARA LIMÓN PERSA

    OpenAIRE

    R. Maldonado T.; G. Almaguer V.; M. E. \\u00C1lvarez S.; E. Robledo S.

    2008-01-01

    El bajo rendimiento promedio de 7 Mg ha-1 que obtienen aproximadamente el 70% de los productores de limón Persa (Citrus latifolia Tan.), en la región norte de Veracruz, México, en comparación con el obtenido en Florida, EE. UU., de 21 Mg ha-1, es atribuido principalmente al manejo inadecuado de la fertilización de las plantaciones. Para contribuir a solucionar este problema, en un huerto localizado en el ejido Chavarrillo, municipio de Emiliano Zapata, Veracruz, se estudiaron cuatro tratamien...

  1. PENGARUH METFORMIN DOSIS RENDAH JANGKA PENDEK TERHADAP RISIKO BERKEMBANGNYA MENJADI DM TIPE-2 PADA PREDIABETES NON OBES

    Directory of Open Access Journals (Sweden)

    Djoko Hardiman

    2012-11-01

    Full Text Available Metformin was reported to decrease the risk of type-2 DM establishment in the obese prediabetic individual. While whether low-dose short-term metformin administration decrease the risk of type-2 DM establishment in the non-obese prediabetic individual was not yet reported so far. The study was to determine if insulin resistance control by low-dose short-term metformin administration in the non-obese prediabetic individual might decrease the risk of type-2 DM establishment. The present study was prospective, experimental study with pretest-posttest control group design. It was conducted on the first degree relative of the type-2 DM patient who met the criteria of non obese prediabetic individual. Subjects were randomly classified into treatment group (designed for metformin administration, and the control group (designed for placebo administration. The prediction of atherosclerosis risk was based on the formula of Insulin Resistance In dex (IRI. The results show that significant difference between pre and post metformin administration term were p=0.003, p=0.051 and p=0,259 for insulin level, insulin 2 hrs postprandial and IRI in the treatment and control group, respectively. While for the fasting glucose level and glucose 2 hrs post-prandial level, the significant differences were p=0.004 and p=0.395 in the treatment and control group, respectively. The study concluded that the low-dose short-term metformin administration might significantly decrease the risk of type-2 DM establishment in the non-obese prediabetic individual.

  2. Neutron dose localized radiation therapy treatments in pelvic area; Dosis neutronica en tratamiento de radioterapia localizados en zonas pelvica

    Energy Technology Data Exchange (ETDEWEB)

    Terron, J. A.; Exposito, M. R.; Barquero, R.; Domingo, C.; Garcia-Fuste, M. J.; Amgarou, K.; Gomez, F.; Leganes, J. L.; Sanchez-Doblado, F.

    2011-07-01

    The peripheral dose of neutrons is currently a matter of great interest. Therefore, it has carried out a project to evaluate the dose of neutrons and a model is designed to meet this dose from the reading of a digital detector. The aim of this paper is to study the behavior of the dose in different organs for treatment of rectal, bladder or gynecological pathologies.

  3. Reference dose levels in dental radiology Spanish; Niveles de dosis de referencia en la radiologia dental espanola

    Energy Technology Data Exchange (ETDEWEB)

    Velasco Hidalgo, F.; Velasco Hidalgo, E.; Alcaraz-Saura, M.; Martinez Garcia-Cervantes, A.; Andreu-Galvez, M.; Martinez-Beneyto, Y.; Alcaraz Banos, M.

    2011-07-01

    Our goal is to evaluate the DRLs to obtain a diagnostic image of a second upper molar in the usual conditions of clinical practice in recent years to assess the evolution of the doses administered to the patient during the last 8 years.

  4. External management system, occupational dose: Design and Implementation; Sistema de gestion externa dosis ocupacional: diseno e implementacion

    Energy Technology Data Exchange (ETDEWEB)

    Ribeiro da silva, C.; Mauricio, C. L. P.; Silva, H. L. R.; Souza-Santos, D.; Bittencourt, R. v.

    2013-07-01

    The results obtained with the use of the system has made it possible to better assess the worker with respect to radiation safety received according to their professional activity. This assessment allows to improve supervision in institutions and the use of teams of Security. (Author)

  5. Evaluation of the enter surface dose, dose in organ and E effective dose, received by personnel and patients in studies of endoscopic retrograde cholangeopancreatography in the General Hospital of Mexico; Evaluacion de la dosis de entrada superficie, dosis en organo y dosis efectiva E, recibidas por personal y pacientes en estudios de colangiopancreatografia retrograda endoscopica en el Hospital General de Mexico

    Energy Technology Data Exchange (ETDEWEB)

    Reyes, S.; Gama T, G. [Calidad XXI SA de CV, Zacatecas 67-007 Col. Roma, 06700 Mexico D.F. (Mexico); Beristain, M.; Espino, H. [Hospital General de Mexico, Dr. Balmis 148, Col. Doctores, 06726 Mexico D.F. (Mexico)]. e-mail: cxxi@prodigy.net.mx

    2006-07-01

    The ESD for patient and personal is measured: gastroenterologuist endoscopist G1, A1 Assistant and A2 instrumentist that carried out 22 independent therapeutic procedures of CPRE, in a fluoroscopy equipment Toshiba trademark with tube under the table, operated in automatic exposure mode, CAE to average tensions of 80 kVp. The measurement is carried out with film dosemeters of double emulsion Kodak Type 2 trademark, calibrated in terms of H{sup *} for the energy of the {sup 137} Cs, first it is determined the films sensitivity like function of the optical density DO, and second the ESD for the effective energy of the radiation beam (50 keV), in three different points from the dosemeter (C, D and H). The films was placed for the personnel in: right hand, front (eye), thyroid and thorax (under D and out F of the lead apron); in the case of the patient three positions were used: thorax, hepatic region and pelvis. The mean values of the ESD and it standard deviation SD in mGy units are determined by: study, personnel, film position in doctor and patient, dosemeter measurement point. The calculated doses in organ are also determined for the patient in the thorax region, liverwort and pelvis its are agreement with the NRPB SR 262 report. Finally the H{sub E} and E for medical personnel and patients are estimated demonstrating that its are not exceeded the annual dose limits for the case of the OEP. In the case of the the OEP have for the D thorax an ESD{sub max} = 0.04 mGy that one corresponds an H{sub E} = 0.02 and E = 0.01 mSv. (Author)

  6. Evaluación toxicológica en ratas Sprague-Dawley de Interleuquina-2 y del candidato vacunal FPCR3, terapia combinada en pacientes con SIDA

    Directory of Open Access Journals (Sweden)

    D. Porras

    2004-01-01

    Full Text Available En busca de nuevas fórmulas terapéuticas para combatir la infección por el virus de inmunodeficiencia humana se han desarrollado diferentes tipos de vacunas, entre las que se encuentran las que estimulan la respuesta de linfocitos T citotóxicos contra antígenos del VIH. A partir de la obtención en el Centro de Ingeniería Genética y Biotecnología (La Habana, Cuba de un candidato vacunal que utiliza como vector el virus de la viruela aviar modificado con genes que expresan proteínas anti-VIH, se ha diseñado un estudio clínico que combina la aplicación de este producto (FPCR3 con la terapia antirretroviral de alta eficiencia y dosis bajas de Interleuquina-2 humana recombinante (IL-2hr. Antes de ensayar estos productos biotecnológicos en pacientes con el síndrome de inmunodeficiencia adquirida se hizo necesario realizar pruebas toxicológicas para evaluar su seguridad, para lo cual se diseñaron 2 estudios de toxicidad aguda en los que se evaluó la respuesta sistémica y local de ratas Sprague-Dawley a dosis superiores a la que se administrará en los pacientes incluidos en el estudio clínico piloto. Se utilizaron 50 ratas de la sublínea Cenp: SPRD (Sprague-Dawley en el estudio de toxicidad aguda de Interleuquina-2hr y 70 animales de esta misma especie y sublínea para el realizado al candidato vacunal FPCR3. Los productos se administraron por vía subcutánea e intramuscular respectivamente a niveles de 30, 60 y 90 veces la dosis terapéutica. En el estudio realizado al candidato vacunal FPCR3 se incluyeron 3 grupos en los que se realizaron administraciones repetidas, a fin de evaluar de forma preliminar la tolerancia local de este producto. En ambos estudios se incluyó un grupo control inoculado con el placebo de las formulaciones. Se realizó observación clínica diaria y se llevó a cabo el estudio histopatológico de los órganos diana y del sitio de administración. No se evidenciaron signos de toxicidad ni efectos adversos

  7. Anti-thyroid drugs or {sup 131}I therapy to control the hyperthyroidism of graves disease: a cost-effectiveness analysis; Tratamento clinico com drogas antitireoidianas ou dose terapeutica de Iodo-131 no controle do hipertireoidismo na doenca de Graves: avaliacao dos custos e beneficios

    Energy Technology Data Exchange (ETDEWEB)

    Cruz Junior, Antonio Fiel; Takahashi, Miriam Hideco; Albino, Claudio Cordeiro [Universidade Estadual de Londrina, PR (Brazil)]. E-mail: afiel@bs2.com.br

    2006-12-15

    In this study, we set out to evaluate the costs and effectiveness of the 2 most used therapies in our region, ATD or RAI. 23 patients, 6 men and 16 women, with a mean age of 35.4 years, treated with ATD, and 35 patients, 5 men and 30 women, mean age of 39.4 years, treated with RAI, were studied. After 2 years receiving ATD, 21 patients achieved euthyroidism and 2 remained hyperthyroid. In the RAI group, 21 patients presented hypothyroidism and 13 became euthyroid. To calculate the costs of each therapy, we analyzed the number of visits during this period, the laboratory data and the drugs needed, such as tiamazol and/or thyroxine. The group treated only with ATD needed a higher number of visits and laboratory measurements, with the mean total cost of R$ 1,345.81, while the RAI group spent a mean amount of R$ 622.94. Therefore, the costs of the RAI treatment were 53.5% lower than clinical therapy with ATD. The present study demonstrates that RAI treatment has a lower cost than ATD, being very effective in controlling the hyperthyroidism of Graves' disease. (author)

  8. Study of antiretroviral mutants in HIV patients with treatment failures and the effect of risk factors in the virological failures Estudio de mutantes resistentes a los antiretrovirales en pacientes con VIH con falla terapeutica y efecto de los factores de riesgo en el tratamiento

    Directory of Open Access Journals (Sweden)

    Lizeth Taylor-Castillo

    2005-12-01

    Full Text Available INTRODUCTION: Information about HIV phenotypes of resistant to available ART and the influence of different risk factors on virological failures (VF in Costa Rican HIV positive patients prior or during HAART is unknown. MATERIALS AND METHODS: Eighty nine samples, 72 VF and 17 basal (before treatment were analyzed by examining resistant mutants in reverse transcriptase (RT and protease (PT regions using Trugene or LIPA genotyping kits. Sixty eight control patients were selected and relevant information was collected in a questionnaire. RESULTS: Poor adherence, presence of resistant mutations and number of treatment's changes were the only significant factors found (p = 0.006, 0.04 and 0.01 respectively. From 66 sequenced samples, 78%, 50% and 50% showed resistance to NRTI (nucleoside reverse transcriptase inhibitors, NNRT (non-nucleoside reverse transcriptase inhibitors and PI (protease inhibitors, respectively. The most frequent mutations were M41L, M184V, and T215FY in RT and L62PI, L10FIRV and M36I in PT. DISCUSSION: The most important factor related to treatment response in this study was adherence to treatment. Mutations in RT were related to the treatment failure while the ones found in PT were secondary mutations which have been previously described to influence the selection of primary resistance mutations in these regions. The study reveals the urgency to detect resistant mutations in VF to be considered by physicians for selection of treatment schedule, to analyze basal HIV patients for monitoring of the spread of resistant mutations and the importance to reinforce the adherence in the patients for overall treatment outcome.En Costa Rica no se tiene información a cerca de genotipos de resistencia para los tratamientos anti-retrovirales disponibles y la influencia de diferentes factores de riego en la falla virológica (FV de pacientes VIH positivos previo o durante su tratamiento. Ochenta y nueve muestras, 72 FV y 17 basales, fueron analizadas con Trugene o LIPA para la detección de mutantes de resistencia en la transcriptasa reversa (TR y en la proteasa (PT del VIH. Se seleccionaron sesenta y ocho controles y se recolectó información relevante en un cuestionario. La mala adherencia, la presencia de mutaciones y el número de cambios de tratamiento fueron los únicos factores con significancia encontrados. (p = 0.03, 0.04 and 0.04 respectively. De 66 muestras secuenciadas, 78%, 50% y 50% mostraron resistencia a los inhibidores análogos y no análogos de nucleótidos para la TR y la PT respectivamente. La mutaciones más frecuentes fueron M41L, M184V, y T215FY en la TR y L62PI, L10FIRV y M36I en la PT. La adherencia fue el factor más importante relacionado con la respuesta al tratamiento. Las mutaciones encontradas en la TR estaban relacionadas al tratamiento mientras que las de la PT fueron mutaciones secundarias que propician la aparición de las mutaciones asociadas a resistencia en esa región. Este estudio revela la necesidad de detectar mutantes de resistencia en pacientes con FV y de estudiar las muestras basales. Además la importancia de reforzar la adherencia en los pacientes para una mejor respuesta al tratamiento.

  9. Actividad hipotrigliceridémica de un extracto de rosa de Jamaica (Hibiscus sabdariffa L. al administrarse antes y durante las comidas

    Directory of Open Access Journals (Sweden)

    Rodrigo Castañeda

    2015-11-01

    Full Text Available a elevación de los lípidos sanguíneos se ha convertido en un riesgo común de enfermedades cardiovasculares,en especial en el caso del colesterol y triglicéridos, también a problemas pancreáticos, de la córnea, bazo e hígado.Hibiscus sabdariffa L., es una especie medicinal de la familia Malvaceae, su efecto sobre la reducción de los lípidos séricos se ha mencionado en varios estudios. El objetivo del presente estudio consistió en evaluar la actividad de un extracto acuoso de los cálices de H. sabdariffa, para reducir los lípidos séricos en dos grupos de individuos, con valores de triglicéridos mayores de 150 mg/dL, al recibir una dosis de 15 mg de antocianinas totales al día, dividida en tres veces, por un periodo de dos meses para establecer su influencia, dependiendo del momento de su administración, un grupo recibiéndola antes de la comida y otro durante la misma. El extracto de H. sabdariffa mostró un efecto hipotrigliceridémico significativo (p = 0.034, al finalizar el tratamiento, únicamente al administrar el extracto antes de las comidas. Al mismo tiempo, no se observó alteración en los niveles de colesterol total, colesterol contenido en las lipoproteínas de baja densidad y colesterol contenido en las proteínas de alta densidad en ninguno de los dos grupos evaluados. Los resultados sugieren que los extractos acuosos de H. sabdariffa podrían ser utilizados para ejercer una acción en los triglicéridos plasmáticos, dependiente del consumo de alimentos, y del momento de administración.

  10. Heparinización directa del paciente frente a heparinización del circuito extracorpóreo en hemodiálisis: estudio comparativo

    Directory of Open Access Journals (Sweden)

    Raquel Pelayo Alonso

    2015-03-01

    Full Text Available Objetivo: Determinar si la forma de administración de la heparina durante el tratamiento con hemodiálisis influye en el estado de coagulación del sistema extracorpóreo. Metodología: Estudio cuasiexperimental en 27 pacientes en Hemodiálisis crónica. Se establecen dos periodos de estudio. En el primero, la heparina prescrita se administra a través del acceso vascular y durante el segundo periodo, a través del botón arterial del sistema extracorpóreo. Resultados: Se estudiaron 27 pacientes, siendo el 37% mujeres, y la edad media 68,63±17,44. El 63% de los pacientes realizaba Hemodiafiltración on line postdilucional. No hubo diferencias estadísticamente significativas en cuanto a la dosis y parámetros de diálisis, el AV, el tratamiento anticoagulante ni la técnica de HD. En cuanto al estado de coagulación, si agrupamos por puntuación mayor o menor de 5, en el primer periodo, el porcentaje medio agrupado inferior a 5 puntos alcanza el 94,09% mientras que en el segundo periodo es de 97,1%, lo que sí resulta estadísticamente significativo (p=0,035. Conclusiones: Según nuestro estudio, administrar la Heparina sódica en el circuito extracorpóreo mejora el estado final de coagulación del sistema, lo que supone una menor pérdida sanguínea para el paciente.

  11. iDESWEB: Práctica 9: PHP 3 (MySQL y acceso a una base de datos)

    OpenAIRE

    Luján Mora, Sergio

    2012-01-01

    Aprender a administrar una base de datos con MySQL. Conocer algunas herramientas que ayudan a administrar una base de datos de MySQL. Aprender a acceder a una base de datos desde PHP. Aprender a realizar una consulta SELECT y mostrar el resultado en una página web.

  12. iDESWEB (3ª ed.): Práctica 10: PHP 3 (MySQL y acceso a una base de datos)

    OpenAIRE

    Luján Mora, Sergio

    2013-01-01

    Aprender a administrar una base de datos con MySQL. Conocer algunas herramientas que ayudan a administrar una base de datos de MySQL. Aprender a acceder a una base de datos desde PHP. Aprender a realizar una consulta SELECT y mostrar el resultado en una página web.

  13. Analysis of FPGA filter in Computed Tomography Images for Radioactive Dose Reduction; Analisis del Filtro FPGA en Imagenes de Tomografia Computarizada para la Reduccion de Dosis Radiactiva

    Energy Technology Data Exchange (ETDEWEB)

    Parcero, E.; Vidal, V.; Verdu, G.; Arnal, J.; Mayo, P.

    2014-07-01

    In this study, different filtering methods are compared on an image of mini-MIAS database (consisting of a collection of mammographic images). Methods employees are PGFM (Peer Group Fuzzy Metric), NDF (Non-linear Diffusion Method) a combination of these two, and FPGA (Fuzzy Peer Group Average). (Author)

  14. Dose profile measurement in computerized axial tomography equipment using thermoluminescent dosemeters; Medicion del perfil de dosis en equipos de tomografia axial computarizada usando dosimetros termoluminiscentes

    Energy Technology Data Exchange (ETDEWEB)

    Azorin V, J.C.; Falcony, C.; Azorin N, J. [Centro de Investigacion en Ciencia y Tecnologia Avanzada, IPN, 07000 Mexico D.F. (Mexico)

    2000-07-01

    In this work are presented the results about measuring the radiation dose profile in two equipment of computerized axial tomography (Tac). Thermoluminescent dosemeters (Dtl) of LiF, Mg, Cu, P + Ptfe in form of disks were used which were developed and made in Mexico. The results showed that Dtl are appropriated for these type of studies. (Author)

  15. A study of the dose modulation systems in two multislice CT scanners; Estudio de los sistemas de modulacion de dosis en dos equipos de tomografia computarizada multicorte

    Energy Technology Data Exchange (ETDEWEB)

    Hernandez Giron, I.; Valverde Moran, J.; Mendez Fernandez, R.; Aramburu Nunez, D.; Nunez Villavicencio, C.; Calzado Cantera, A.

    2009-07-01

    Multislice computed tomography (TCMC) is a technique that for its gradual introduction and the spectacular increase in its indications in clinical practice represents the main contribution to the collective dose in diagnostic radiology. It is essential to optimize the protocols maintaining doses as low as possible without affecting the diagnostic quality of images. Automatic tube current modulation systems are a tool currently available in all CT scanners. They adapt the tube current to morphological characteristics of the patient and the anatomical area under study. The aim of this work has been to analyze two scanners from the same manufacturer and featuring similar geometry by assessing the relative dose differences and image quality. Modulation systems of general use can decrease the dose in a 20-60% with a reduction in the signal to noise ratio between 6% and 37%. Dedicated cardiac-CT modulation system gave rise to high relative differences (36-40%) even when varying the heart rate. Significant changes in image quality were not appreciated though the motion of the heart has not been simulated in this study. (Author) 14 refs.

  16. Technique of reducing doses CR using non-linear diffusion method; Tecnica de reduccion de dosis en CR usando el metodo de Difusion no lineal

    Energy Technology Data Exchange (ETDEWEB)

    Vidal Gimeno, C.

    2012-07-01

    A technique to obtain good quality in the image, in order to show the viability of CR dose reduction is presented. especially in pediatric applications, while maintaining the integrity of the diagnosis.

  17. Dose distribution perturbation due to a Co-Cr-Mo prosthesis; Perturbacion introducida en la distribucion de dosis por una protesis de Co-Cr-Mo

    Energy Technology Data Exchange (ETDEWEB)

    Castro Novais, J.; Rodriguez Rodriguez, C.; Cabello Murillo, E.; Fernandez Leton, P.; Perez Moreno, J. M.; Lopez Fernandez, A.; Ferrando Sanchez, A.; Martinez Gomez, L. C.

    2009-07-01

    Knowledge of the attenuation and interface effects when irradiating metallic prosthesis is necessary for the radiotherapy treatment of patients with this kind of implants. This report studies the dose distribution of a 6 MV photon beam in the vicinity of a 1,5 cm diameter Co-Cr-Mo prosthesis. Measurements with Gafchromic EBT radiochromic films have been made. Two blocks of cut films have been placed next to the prosthesis, one in each side. Forty two films reaching a height of 1 cm have been piled up in each block. A spatial resolution equal to the thickness of one film (0,24 mm) is achieved. The results show 28% attenuation and the production of a 42% overdose at the entrance interface, 12% and 3% at 1 mm and 2 mm away from the prosthesis respectively. A 5 mm build-up region is originated in the exit interface, where the under dose is less than 10%. The knowledge of the transmission factor and the interface effects allows us to assess the dose calculated by the treatment planning system. (Author) 11 refs.

  18. Respon Pertumbuhan Dan Produksi Kailan (Brassica oleraceae L.) Pada Pemberian Pupuk Anorganik Dan Berbagai Dosis Pupuk Organik Cair Paitan (Tithonia diversifolia (Hemsl.) Gray)

    OpenAIRE

    Sinaga, Posma

    2015-01-01

    POSMA SINAGA :The Application of anorganic fertilizer and some dossages of Liquid Organic Fertilizer of paitan (Tithonia diversifolia) on the Growth and Yield of Mustard (Brassica oleraceae L.), supervised by dan MEIRIANI and YAYA HASANAH. Generally, paitan is not used, known as weeds and just used as animal feed and it rest just become waste. Paitan has potential as the nutrition adder for plant. Therefore, the application of liquid organic fertilizer from paitan is hoped can increase t...

  19. Peripheral doses in modulated intensive radiotherapy (MIRT) and its implications in radiological protection; Dosis periferica en radioterapia de intensidad modulada (IMRT) y su implicancia en proteccion radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Cobos, Agustin C.; Sanz, Dario E.; Alvarez, Guilhermo D., E-mail: cletocobos@hotmail.com, E-mail: dsanz@fuesmen.edu.ar, E-mail: galvarez@fuesmen.edu.ar [Fundacion Escuela de Medicina Nuclear (FUESMEN), Mendonza (Argentina)

    2013-07-01

    A calculation model based on the theory of photon transport, to estimate the peripheral energy fluence (fluence occurring outside the radiation beam) produced by the dispersions of photon compensating filters used was developed in IMRT mode, in a treatment room radiotherapy service of FUESMEN. In order to validate the model were experimentally determined fluences and peripheral dose for three different sizes of compensating filters. It was found that there is a slight systematic overestimation model with respect to experimental results. The experimental values also allowed the comparison of the peripheral doses with other modalities. Furthermore, a model was developed to estimate the annual dose that occurs at any point to be protected with a shield, from the theoretical values obtained from peripheral energy flow. Using the theoretical values automatically allowed to take a conservative approach because of the slight overestimation already mentioned, the couple have a calculation model for widespread use. It was found that the contribution of the peripheral dose to the annual dose is more than significant, thus suggesting that the same should be considered in the design calculations of secondary barriers.

  20. Dosimetric behavior of thermoluminescent dosimeters at low doses in diagnostic radiology; Comportamiento dosimetrico de dosimetros termoluminiscentes a bajas dosis en radiodiagnostico

    Energy Technology Data Exchange (ETDEWEB)

    Del Sol F, S.; Garcia S, R.; Guzman M, J.; Sanchez G, D.; Rivera M, T. [IPN, Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada, Av. Legaria 694, Col. Irrigacion, 11500 Mexico D. F. (Mexico); Ramirez R, G. [Hospital Juarez de Mexico, Av. IPN 5160, Col. Magdalena de las Salinas, 07760 Mexico D. F. (Mexico); Gaona, E., E-mail: susi2489@hotmail.com [Universidad Autonoma Metropolitana, Unidad Xochimilco, Calz. del Hueso 1100, Col. Villa Quietud, 04960 Mexico D. F. (Mexico)

    2015-10-15

    Thermoluminescent (Tl) characteristics of TLD-100, LiF:Mg,Cu,P, and CaSO{sub 4}: Dy the under homogeneous field of X-ray beams of diagnostic irradiation and its verification using thermoluminescent dosimetry is presented. The irradiations were performed utilizing an X-ray beam generated by a Radiology Mexican Company: MRH-II E GMX 325-AF SBV-1 model, with Rotating Anode X-Ray Tube installed in the Hospital Juarez Norte de Mexico in Mexico City. Different thermoluminescent characteristics of dosimetric material were studied, such as, batch homogeneity, Tl glow curve, Tl response as a function of X-ray dose, reproducibility and fading. Materials were calibrated in terms of absorbed dose to the standard calibration distance and positioned in a generic Phantom was used. Dose verification and comparison with the measurements made with that obtained by TLD-100 were analyzed. Preliminary results indicate the dosimetric peak appears at 243, 236 and 277 ± 5 degrees C respectively, these peaks are in agreement with that reported in the literature. Tl glow curve as a function of X-ray dose showed a linearity in the range from 1.76 mGy up to 14.70 mGy for all materials. Fading for a period of one month at room temperature showed low fading LiF:Mg,Cu,P, medium and high for TLD-100 and CaSO{sub 4}: Dy. The results suggest that the three materials are suitable for measurements at low doses in radiodiagnostic, however, for its dosimetric characteristics are most effective for individual applications: personal dosimetry and monitors limb (LiF:Mg,Cu,P), clinical dosimetry and environmental (TLD-100 and CaSO{sub 4}: Dy). (Author)

  1. Dose to patients and professionals in cardiology interventional: Progress of multicenter group Doccaci; Dosis a pacientes y a profesionales en cardiologia intervencionista: Avances del grupo multicentrico DOCCACI

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez, R. M.; Vano, E.; Fernandez, J. M.; Goicolea Ruigomez, J.; Pifarre, X.; Escaned, J.; Rovira, J. J.; Garcia del Blanco, B.; Carrera, F.; Diaz, J. F.; Ordiales, J. M.; Nogales, J. M.; Hernandez, J.; Bosa, F.; Rosales, F.; Saez, J. R.; Soler, M. M.; Romero, M. A.

    2013-07-01

    The multidisciplinary group and multicenter DOCCACI (dosimetry and quality assurance in interventional cardiology), sponsored by the section of haemodynamics of the Spanish society of Cardiology, is intended to propose reference levels to doses received by patients in interventional cardiology procedures such as recommended by the International Commission on radiological protection It also investigates the doses received by professionals, in particular dose in Crystallyne whose recommended limit dose has been reduced recently from 150 to 20 mSv/year. (Author)

  2. Determination of effective dose for workers hemodynamics service using double dosimetry; Determinacion de la dosis efectiva para los trabajadores del servicio de hemodinamica usando doble dosimetria

    Energy Technology Data Exchange (ETDEWEB)

    Ruiz Lopez, M. A.; Lobato Munoz, M.; Jodar Lopez, C. A.; Ramirez Ros, J. C.; Jerez Sainz, M. I.; Pamos Urena, M.; Carrasco Rodriguez, J. L.

    2013-07-01

    The use of an additional dosimeter at the level of the neck above the lead apron we can provide an indication of the dose in the head (the Crystal dose). In addition, it is possible to combine the two readings of the dosimeter to provide an improved estimate of the effective dose. In the hemodynamics service of our Hospital we have maintained a worker for 3 years with the double dosimetry read monthly. With the readings from these dosimeters will do following algorithms, several estimates of the effective dose to see if, with working conditions that occur in this service, it would be necessary to extend this practice to the rest of the workers to get a better estimation of effective dose. (Author)

  3. Coincidence in the dose estimation in a OEP by different methods; Coincidencia en la estimacion de dosis en un POE por diferentes metodos

    Energy Technology Data Exchange (ETDEWEB)

    Guerrero C, C.; Arceo M, C.; Brena V, M. [ININ, Km. 36.5, Carretera Mexico-Toluca, 52750 La Marquesa, Estado de Mexico (Mexico)]. e-mail: cgc@nuclear.inin.mx

    2007-07-01

    The case of an apparent overexposure to radiation according to that indicated for the thermoluminescent dosemeter 81.59 mSv (TLD) of a occupationally exposed hard-working (POE), for that was practiced the study of biological dosimetry. The estimated dose was 0.12 Gy with which was proven the marked dose registration by the TLD dosemeter. It was concluded that both doses are the same ones. (Author)

  4. Development of the model MAAP5-DOSE for dose analysis in Cofrentes NPP; Desarrollo del modelo MAAP5-DOSE para analisis de dosis en C.N. Cofrentes

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, C.; Diaz, P.; Ibanez, L.; Lamela, B.; Serrano, C.

    2013-07-01

    Iberdrola Ingenieria y Construccion has developed a model of Cofrentes NPP with code MAAP5-DOSE in order to be able to assess in realistic conditions the the expected dose in points and radiological consequences of severe accident of local action.

  5. Glandular dose in breast tomosynthesis examinations: Preliminary study with a sample of patients; Dosis glandular en examenes de tomosintesis de mama: estudio preliminar con una muestra de pacientes

    Energy Technology Data Exchange (ETDEWEB)

    Castillo, M.; Chevalier, M.; Calzado, A.; Valverde, J.

    2013-07-01

    The aim of this study is to analyze the mean glandular dose administered to a group of patients with a tomography system (Selenia Dimensions) service installed on a large hospital in which routine tests are done and screening. (Author)

  6. Pilot study of the dose in crystalline lens in the interventional radiology practice; Estudio piloto de la dosis en cristalino en la practica de radiologia intervencionista

    Energy Technology Data Exchange (ETDEWEB)

    Castro, A.; Martinez, A.; Fernandez, A.; Molina, D. [Centro de Proteccion e Higiene de las Radiaciones, Carretera de la Cantera, Victoria II, Km. 21.5 Guanabacoa, La Habana (Cuba); Sanchez, L.; Diaz, A., E-mail: ailza@cphr.edu.cu [Hospital Clinico Quirurgico Hermanos Ameijeiras, San Lazaro 701, Centro Habana, La Habana (Cuba)

    2014-08-15

    The interventional radiology involves considerable exposure levels for the occupationally exposed personnel (OEP). The doses can encompass a wide range of values in dependence of the function that develops the personnel and the complexity of each procedure. In organs like the crystalline lens and skin values can be reached that imply the appearance of deterministic effects if is not fulfilled the appropriate measures of radiological protection. This has been demonstrated through multiple studies, among those that the retrospective study of damages in the crystalline lens and dose has been one of those most commented, known as RELID. The objective of that study was to examine the opacity prevalence in the crystalline lens in workers linked to the interventional cardiology and to correlate it with the occupational exposition. The obtained results contributed to that the ICRP recommend a new limit value of equivalent dose for crystalline lens of 20 mSv in one year. With the objective of analyzing the operational implications, in the radiological surveillance programs that they could originate with the new recommendations was developed a pilot study to evaluate the dose in crystalline lens in the OEP linked to the interventional radiology in a Cuban hospital. For this, an anthropomorphic mannequin RANDO-ALDERSON was used on which thermoluminescent dosimeters were placed below and above of the leaded apron and in different positions at level of the crystalline lens: above, below and to the sides of the leaded lenses that the personnel uses routinely. The mannequin was located on the same positions that occupy the main specialist that execute the procedure, as well as of the nurse to assist him. The measurements were made simulating the more representative procedures about complexity, duration time and exposure rate. The used dosimeters were RADOS model for whole body composed of two thermoluminescent detectors Gr-200 (LiF: Mg, Cu, P) to evaluate personal equivalent dose Hp(10) and dosimeters for crystalline lens with three detectors of the same material to evaluate the personal equivalent dose Hp(3). The selected detectors were previously subjected to tests recommended by the standard IEC-61066 and segregated by their individual sensibility. For the reading dosimeters was used the automatic system TLD RADOS model of the Laboratorio de Dosimetria Externa del Centro de Proteccion e Higiene de las Radiaciones, calibrated in function of the magnitude to evaluate. This study allowed demonstrating that the application of the new established dose limit for crystalline lens can result in different implications from the operational view point in the radiological surveillance programs. Also it facilitated the diffusion of some recommendations regarding type of singular radiological surveillance and use frequency for the OEP during the interventional procedures. (author)

  7. DETERMINACIÓN DE LA DOSIS ÓPTIMA DE REACTIVO FENTON EN UN TRATAMIENTO DE LIXIVIADOS POR FENTON-ADSORCIÓN

    OpenAIRE

    Roger Iván MÉNDEZ NOVELO; José Alfredo PIETROGIOVANNA BRONCA; Beatriz SANTOS OCAMPO; María Rosa SAURI RIANCHO; Germán GIÁCOMAN VALLEJOS; Elba René CASTILLO BORGES

    2010-01-01

    Los lixiviados son el resultado de la percolación de líquidos a través de los desechos sólidos en proceso de estabilización. La complejidad de su tratamiento se debe a que su composición es altamente tóxica y variable. Lo anterior y el suelo altamente permeable de la península de Yucatán, representan un alto peligro a la salud. Se ensayó un tratamiento de oxidación tipo Fenton-adsorción con el que se obtuvieron mejores resultados que con otros tratamientos fisicoquímicos o biológicos reportad...

  8. Dose verification by OSLDs in the irradiation of cell cultures; Verificacion de dosis mediante OSLDs, en la irradiacion de cultivos celulares

    Energy Technology Data Exchange (ETDEWEB)

    Meca C, E. A.; Bourel, V. [Ce. De. Te. Centro Especializado en Terapia Radiante, Viamonte 1861, C1056 Buenos Aires (Argentina); Notcovich, C.; Duran, H., E-mail: edarmeca@gmail.com [Comision Nacional de Energia Atomica, Departamento de Micro y Nanotecnologia, Av. Gral. Paz 1499, 1650 San Martin, Buenos Aires (Argentina)

    2015-10-15

    The determination of value of irradiation dose presents difficulties when targets are irradiated located in regions where electronic equilibrium of charged particle is not reached, as in the case of irradiation -in vitro- of cell lines monolayer-cultured, in culture dishes or flasks covered with culture medium. The present study aimed to implement a methodology for dose verification in irradiation of cells in culture media by optically stimulated luminescence dosimetry (OSLD). For the determination of the absorbed dose in terms of cell proliferation OSL dosimeters of aluminum oxide doped with carbon (Al{sub 2}O{sub 3}:C) were used, which were calibrated to the irradiation conditions of culture medium and at doses that ranged from 0.1 to 15 Gy obtained with a linear accelerator of 6 MV photons. Intercomparison measurements were performed with an ionization chamber of 6 cm{sup 3}. Different geometries were evaluated by varying the thicknesses of solid water, air and cell culture medium. The results showed deviations below 2.2% when compared with the obtained doses of OSLDs and planning system used. Also deviations were observed below 3.4% by eccentric points of the irradiation plane, finding homogeneous dose distribution. Uncertainty in the readings was less than 2%. The proposed methodology contributes a contribution in the dose verification in this type of irradiations, eliminating from the calculation uncertainties, potential errors in settling irradiation or possible equipment failure with which is radiating. It also provides certainty about the survival curves to be plotted with the experimental data. (Author)

  9. Absorbed doses received by infants subjected to panoramic dental and cephalic radiographs; Dosis absorbida recibida por infantes sometidos a radiografias dentales panoramicas y cefalicas

    Energy Technology Data Exchange (ETDEWEB)

    Carrizales, L.; Carreno, S. [Instituto Venezolano de Investigaciones Cientificas. Laboratorio Secundario de Calibracion Dosimetrica. Carretera Panamericana Km. 11. Apartado Postal 21827, Caracas (Venezuela)

    1998-12-31

    The IAEA Report No. 115 recommends that each country or region can establish levels of absorbed doses for each radiographic technique employed in diagnostic. assuming the extended and expensive of this purpose, we have been to begin in a first step with the dentistry area, in order to estimate the dose levels received at crystalline and thyroid level in infants that go to an important public institution in our country to realize panoramic and cephalic radiographs. This work will serve to justify and impel a quality assurance program in Venezuela on the dentistry area which includes aspects such as training for the medical lap referring the justification of the radiological practice, optimization of X-ray units to produce an adequate image quality that delivers to patient an absorbed dose as much lower as reasonably it can be reached without diagnostic detriment. (Author)

  10. Determination of the dose around an ovoid for treatments in intracavitary brachytherapy Hdr; Determinacion de la dosis alrededor de un ovoide para tratamientos en braquiterapia intracavitaria HDR

    Energy Technology Data Exchange (ETDEWEB)

    Rivera M, T. [IPN, Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada, Legaria No. 694, Col. Irrigacion, 11500 Mexico D. F. (Mexico); Velasco V, R. A. E. [Hospital Central Militar, Periferico y Ejercito Nacional s/n, Lomas de Sotelo, 11200 Mexico D. F. (Mexico); Serrano F, A. K. [Hospital Juarez de Mexico, Av. Instituto Politecnico Nacional No. 5190, Col. Magdalena de las Salinas, 03220 Mexico D. F. (Mexico); Azorin N, J., E-mail: trivera@ipn.m [Universidad Autonoma Metropolitana, Unidad Iztapalapa, Av. San Rafael Atlixco No. 186, Col. Vicentina, 09340 Mexico D. F. (Mexico)

    2010-09-15

    On this work the results of the dosimetric measurements are presented around an ovoid of 2 cm diameter. The measurements were carried out using a water mannequin, an ovoid, a radiation gamma source of {sup 192}Ir and thermoluminescent dosemeters. The dosimetry was realized in the direction of the rectum and bladder. To know the effect of the shielding of the devices type Manchester in the dose, the thermoluminescent dosemeters were irradiated to a radiation gamma source of {sup 192}Ir contained in the Gamma med Plus equipment. The planning was realized normalizing the calculation to 2.5 cm from the applicator center on the transverse plane (2.5, 0, 0). The results show that the dose distribution for an ovoid without shielding is more uniform in the transversal plane to the source axis. The results were compared with the calculated results by means of the planning system BrachyVision. While the absorbed dose distribution around an ovoid with shielding is completely anisotropic. This anisotropic is due to the shielding. (Author)

  11. Comparison between calculation methods of dose rates in gynecologic brachytherapy; Comparacion entre metodos de calculo de tasa de dosis en braquiterapia ginecologica8

    Energy Technology Data Exchange (ETDEWEB)

    Vianello, E.A.; Biaggio, M.F.; Dr, M.F.; Almeida, C.E. de [Laboratorio de Ciencias Radiologicas- (L.C.R.)-D.B.B.- UERJ- R. Sao Francisco Xavier, 524- Pav. HLC- sala 136- CEP 20550-013 Rio de Janeiro (Brazil)

    1998-12-31

    In treatments with radiations for gynecologic tumors is necessary to evaluate the quality of the results obtained by different calculation methods for the dose rates on the points of clinical interest (A, rectal, vesicle). The present work compares the results obtained by two methods. The Manual Calibration Method (MCM) tri dimensional (Vianello E., et.al. 1998), using orthogonal radiographs for each patient in treatment, and the Theraplan/T P-11 planning system (Thratonics International Limited 1990) this last one verified experimentally (Vianello et.al. 1996). The results show that MCM can be used in the physical-clinical practice with a percentile difference comparable at the computerized programs. (Author)

  12. Analysis of the evolution of the collective dose in nuclear power plants in Spain; Analisis de la evolucion de la dosis colectiva en las centrales nucleares de Espana

    Energy Technology Data Exchange (ETDEWEB)

    Ponjuan Reyes, G.; Ruibia Rodiz, M. A. de la; Rosales Calvo, M.; Labarta Mancho, T.; Calavia Gimenez, I.

    2011-07-01

    This article presents an analysis of the evolution of occupational collective dose of the Spanish nuclear power plants during the period 2000 - 2008 within the international context, by the Nuclear Safety Council (CSN) in order to have information contrasted to assessing the extent of application of the ALARA criteria in the Spanish plants and identify areas of priority attention.

  13. Development of procedures Dose Levels interventional pediatric cardiology Chile; Evolucion de los Niveles de Dosis en procedimientos cardiologicos intervercionistas pediatricos en Chile

    Energy Technology Data Exchange (ETDEWEB)

    Ubeda de la Cerda, C.; Miranda Gonzalez, M.; Vano Carruana, E.; Leyton Legues, F.

    2011-07-01

    The aim of this paper is to show the evolution of these dose values during the years 2009 and 2010, which have been quantified as part of the IAEA entitled Ensuring Radiological Protection of Patients in General Medical and during Exhibitions (TSA3)RLA/9/067.

  14. Determination of optimal doses of radiation for the plant breeding of pseudo cereals; Determinacion de dosis optimas de radiacion para el mejoramiento de seudocereales

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez J, J. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico); Gomez P, L. [Universidad Nacional Agraria La Molina, Lima (Peru)]. e-mail: jgj@nuclear.inin.mx

    2005-07-01

    With the purpose of promoting the use of the radiations for the plant breeding of pseudo cereals, it was determined a simple and economic method that allows the quick selection of radiation dose that induce in the vegetable organisms the changes wanted. For it it was work with quinua seeds (Chenopodium quinoa Willd.) an Andean pseudo cereal that, due to their nutritious and physiologic characteristics it is considered by the FAO like one of the foods of the future and for the NASA like an organism that is good to remove the carbon dioxide from the atmosphere and at the same time, to generate food, oxygen and water for the crew during the space missions of long duration and that it has already improved by means of the radiation application. The proposed method consists on the evaluation, of the embryonic structures (radicule, hypocotyl and cotyledons) in the irradiated seeds as well as of the development of root, primary shaft and true leaves in the plants. The changes in the growth, form, number and color of the structures as well as the time of appearance of each one, allow to predict the morphological changes and inclusive some physiologic ones that will have the mature organisms, so that in only three weeks it is possible to select the doses more appropriate. (Author)

  15. Dose estimation for the eye lens dealing with radioactive wastes; Abschaetzung der Dosis fuer die Augenlinse beim Umgang mit radioaktivem Abfall

    Energy Technology Data Exchange (ETDEWEB)

    Krause, A.; Lorenz, B.; Wuertemberger, M. [GNS Gesellschaft fuer Nuklear-Service mbH, Essen (Germany)

    2013-07-01

    A significant reduction of the dose limit for the lens of the eye is currently discussed in international committees. The ICRP had recommended a reduction from 150 mSv to 20 mSv, the IAEA-BSS have already adopted this value and the Euratom-BSS propose this too. In the practice of radiation protection the compliance with the limit for the lens of the eye has played a minor role so far. This was in practice assured by the compliance with the limit for the effective dose. With a possible stipulation of a much lower value in the Radiation Protection Ordinance (StrlSchV), the question of compliance arises again. When handling radioactive waste where often gamma radiation is dominant it may happen that the (unshielded) eye region is much more exposed as the location of the (shielded) personal dosimeter. A theoretical study of typical GNS-workplaces in radioactive waste management has shown that up to a factor of 4 higher exposures may occur. A generic assessment under very conservative assumptions that was done first did not allow for the conclusion that the compliance of the new dose limit for the lens of the eye is given by complying with the limit for the effective dose. To get a more reliable basis the exposure situation will now be investigated by measurements that are carried out with specific TLDs provided by the MPA Dortmund. (orig.)

  16. Doses in pediatric urinary studies guided by fluoroscopy: methodology oriented to the education; Dosis en estudios urinarios pediatricos guiados por fluoroscopia: metodologia orientada a la educacion

    Energy Technology Data Exchange (ETDEWEB)

    Cotelo, E.; Castillo, C.; Padilla, M. [Escuela Universitaria de Tecnologia Medica, Facultad de Medicina, Universidad de la Republica (UdelaR) Av. Italia s/n 3er. piso CP 11600, Montevideo (Uruguay); Rabin, C. [Instituto de Fisica, Facultad de Ciencias, UdelaR, Montevideo (Uruguay)]. e-mail: elecote@adinet.com.uy

    2006-07-01

    The challenge of the Radiological Protection (RP) it is to implement Programs of Quality Guarantee without limiting them to the quality control. Radiologists and technicians should to familiarize with the dosimetry of patient, and the specialists in RP need to have clinical practice. The children (more radiosensitive that the adults) they present difficulties own to establish clinical approaches of quality due to their variations anthropomorphic (wide age range) and to specific illnesses. Also, those studies guided by fluoroscopy are of difficult standardization by the numerous ones pathologies (with anatomic-physiologic variations). It was determined the Kerma Area Product (P{sub K,A} ) in 25 subjected patients to cystourethrographies carried out by the same radiologist doctor. Its were registered anthropometric data, technical parameters, irradiated area, number radiographs, P{sub K,A} , pathologies. The complications (collaboration, delays in urinating), the radiological protocols and the learning curve of the radiologist were analyzed. When knowing the 'in situ' dose, the radiologist could relate it with those variables that determine it, optimizing immediately it practice. The hope wide range of obtained P{sub K,A} (0.17 - 1.85) Gy.cm{sup 2} deepened the analysis. The measurement of P{sub K,A} (non mandatory in all Latin America) it constitutes an incomparable educational tool in RP, should be used, at least, in reference hospitals. (Author)

  17. Set the initial reference state of a team brachytherapy high dose rate; Establecimiento del estado de referencia inicial de un equipo de braquiterapia de alta tasa de dosis

    Energy Technology Data Exchange (ETDEWEB)

    Clemente Gutierrez, F.; Diaz Fuentes, R.; Cabello Murillo, E.; Casa de Julian, M. A. de la; Ferrando Sanchez, A.; Adaimi Hernandez, P.

    2011-07-01

    You have set the initial reference state for a team of high-rate brachytherapy doses according to the recommendations made in the text used as a reference, being always within the functional tolerances established for the team, or the number associated with each test. The team was ready for clinical use under the provisions of Royal Decree 1566/1998 of Quality Control in Radiotherapy.

  18. Dose by {sup 222} Rn in houses of the Chihuahua city; Dosis por {sup 222} Rn en casas-habitacion de la ciudad de Chihuahua

    Energy Technology Data Exchange (ETDEWEB)

    Colmenero S, L.H.; Talamantes F, C. [ITCH II, Ave. de las Industrias 11101, Chihuahua (Mexico); Villalba, M.L. [UACH, Facultad de Ingenieria, Chihuahua (Mexico); Dobson, P.F. [Laboratorio Nacional Lawrence Berkeley, California (United States); Ortalejo M, B. [UACH, Facultad de Enfermeria y Nutriologia, Chihuahua (Mexico)]. e-mail: luis.colmenero@cimav.edu.mx

    2007-07-01

    Full text: The dose equivalent that the population of the Chihuahua city receives due to the radon in air that joined to values of uranium, thorium and potassium due to the floor and radon in water was determined, they give values very above the international and national norms. The state of Chihuahua contains near 56 locations distributed by the whole state. The city of Chihuahua, capital of the state, is surrounded of rocks with great content of uranium, for what their floor also contains to the {sup 226} Ra that generates to the {sup 222} Rn. The construction of the housings of the city of Chihuahua is mainly of brick, block and adobe; the material to elaborate them is take from the rocks and floor of the surroundings, this makes that the radon is presented in a great quantity of houses of this city. As the floor and water they also contain those natural radionuclides, the total dose equivalent that the inhabitants receive is bigger to other cities of the country. Diverse international organizations dedicated to the radioactivity, indicate that the level of the {sup 222} Rn should not surpass the 148 Bq/m{sup 3}, since this gas produces lung cancer. The state of Chihuahua has an index of deaths on the average by lung cancer of double the national average, the capital of the state also has a high index. The radon concentration in a house depends on the construction material with which was made, as well as of the existent climatic conditions. During the day, this concentration depends mainly on the interior temperature, so during the night and dawn increases the radon concentration. The radon is the biggest source of radioactive dose received by the human being and it can generate a problem of public health if the concentration is high during enough time, for what the city of Chihuahua has the geologic and climatic characteristics to have it. This study was carried out in 50 house-room of the city of Chihuahua. Built houses with brick, block and adobe were selected. The quantification of the radon was made every 10 minutes during three continuous days, with the AlphaGUARD Pro2000 equipment that also measures atmospheric parameters. The obtained data were analyzed with the Genitron software and was analyzed the variation of the radon concentration with the atmospheric parameters and a hours in that the person is in the room. Finally they were carried out the dosimetry calculations due to the radon in air, adding it with the dose received by floor and water due to the natural radionuclides. As it was expected, the city of Chihuahua when being on an uranifer floor and the materials of construction of housings are elaborated starting from this floor, high concentrations were presented of {sup 222}Rn. The third part of the houses had a bigger average to the 148 Bq/m{sup 3} in air, with values average for the whole day of up to 276 Bq/m{sup 3}, as well as maxima values near to 900 Bq/m{sup 3}. When making the calculation of the concentration for the night and dawn that it is when the one inhabitant remains in the room and that to avoid the cold he closes doors and windows, the radon concentration ascended until values of 305 Bq/m{sup 3}. The calculation of the dosimetry was in high values for the radon of until 3.2 mSv/year that adding to the floor values (0.63 mSv/year) and water (0.016 mSv/year) it gives a value of 3.85 mSv/year, considering these values very superior to those registered in other cities of the country reported in the bibliography or by the CNSNS. (Author)

  19. Estimate of the dose received in crystalline lens by pediatric interventional cardiologists; Estimacion de la dosis recibida en cristalino por cardiologos intervencionistas pediatricos

    Energy Technology Data Exchange (ETDEWEB)

    Koren, C.; Alejo, L.; Serrada, A., E-mail: cristina.koren@salud.madrid.org [Hospital Universitario La Paz, Servicio de Radiofisica y Radioproteccion, Paseo de la Castellana 261, 28046 Madrid (Spain)

    2014-08-15

    The objective of this work is to estimate the maximum dose accumulated during one year in the crystalline lens of the pediatric interventional cardiologists that work in the Hospital Universitario La Paz. Optically Stimulated Luminescence Dosimeters (OSLDs) were used for to carry out this estimation, placed in the eyes of an anthropomorphic mannequin whose position in the room simulates the more habitual conditions of the clinical practice. Previously to the simulation, different tests to validate the used dosimetric system were realized, including those related with the stability, reproducibility and lector linearity, as well as the angular and energy dependence of the OSLDs. During the simulation the mannequin eyes were irradiated and were measured with OSLDs the rate of superficial equivalent dose in crystalline lens for the different qualities of beam habitually used, as much in fluoroscopy as in acquisition. With the obtained data during three years, corresponding to the fluoroscopy times and the acquisitions number of the interventional procedures carried out; as much therapeutic as diagnostic, and rate by measuring of obtained dose, has been considered the superficial equivalent dose and the equivalent dose at 3 mm deep accumulated in the crystalline lens of the pediatric interventional cardiologist with more work load of the Hospital, during the years 2011 and 2012. None of the obtained maximum values exceed the new dose annual limit in crystalline lens of 20 mSv, recommended by ICRP in April of 2011. (author)

  20. Evaluation of doses received by pediatric and adult patients undergoing to CT exams; Evaluacion de la dosis recibida por pacientes adultos y pediatricos en examenes de tomografia computarizada

    Energy Technology Data Exchange (ETDEWEB)

    Lavie, Maria F. Jimenez; Tejeda, Adalberto Machado, E-mail: felicia@cceem.sld.cu, E-mail: adalberto@cceem.sld.cu [Centro para el Control Estatal de Medicamentos, Equipos y Dispositivos Medicos (CECMED), La Habana (Cuba); Otano, Anisia; Zuniga, Dora Maya [Hospital Pediatrico Centro Habana (Cuba); Perdomo, Jorge Hing; Rodriguez, Gustavo Guadarrama [Hospital Docente Clinico Quirurgico Freyre Andrade, La Habana (Cuba)

    2013-07-01

    This paper aims to evaluated the dose to adult and pediatric patients due to the execution of tests CT scan of head, chest and abdomen, as well as establish a comparative analysis between these results and protocols involving employees to begin a process optimization in the practice.

  1. Comparative analysis of dose levels to patients in radiological procedures guided by fluoroscopy; Analisis comparativo de los niveles de dosis a paciente en procedimientos radiologicos guiados por fluoroscopia

    Energy Technology Data Exchange (ETDEWEB)

    Gomez, Pablo Luis; Fernandez, Manuel; Ramos, Julio A.; Delgado, Jose Miguel; Cons, Nestor, E-mail: pablogll@eresmas.com [Hospital Universitario de Salamanca (Spain). Servicio de Radio fisica y Proteccion Radiologica

    2013-07-01

    This work presents the comparative data of the dose indicators for patient in radiological processes with respect to the values published in the ICRP document. It is analyzed the need for different strategies to communicate to different specialists mechanisms to optimize the radiation beginning with practice by training of second degree level in radiological protection and then, working with them the basics of equipment management to reduce doses without detriment to the welfare purpose.

  2. Estimation of the average glandular dose on a team of tomosynthesis; Estimacion de la dosis glandular media en un equipo de tomosintesis

    Energy Technology Data Exchange (ETDEWEB)

    Nunez Martinez, L. M. R.; Sanchez Jimenez, J.; Pizarro trigo, F.

    2013-07-01

    Seeking to improve the information that gives us an image of mammography the manufacturers have implemented tomosynthesis. With this method of acquisition and reconstruction of image we went from having a 2D to a 3D image image, in such a way that it reduces or eliminates the effect of overlap of tissues. The estimate of the dose, which is always a fundamental parameter in the control of quality of radiology equipment, is more in the case of mammography by the radiosensitivity of this body and the frequency of their use. The objective of this work is the determination of the mean in a team glandular dose of with tomosynthesis mammography. (Author)

  3. Atorvastatin Dosis Tinggi Jangka Pendek Untuk Pencegahan Nefropati Yang Dicetuskan Oleh Kontras Pada Pasien Angina Pektoris Stabil Yang Menjalani Intervensi Koroner Perkutan

    OpenAIRE

    Haykal, Teuku Bob

    2016-01-01

    Used of contrast media in diagnostic and intervention procedure keep rising, causing increased of deterioration renal function because using contrast media. Prevent contrast induced nephropathy (CIN) in patient undergoing percutaneus coronary intervention (PCI) is very impotant. This study aim to investigate whether high dose short term atorvastatin can decreases the incidence of CIN in patient undergoing PCI. This is cross sectional study to compare CIN incidence in high dose short t...

  4. Online patient dosimetry and an image quality audit system in digital radiology; Auditoria en tiempo real de dosis a los pacientes y claidad de imagen en radiologia digital

    Energy Technology Data Exchange (ETDEWEB)

    Fernandez, J. M.; Vano, E.; Ten, J. I.; Prieto, C.; Martinez, D.

    2006-07-01

    The present work describes an online patient dosimetry and an image quality audit system in digital radiology. the system allows auditing of different parameters depending on contents of DICOM (Digital Imaging and Communication in Medicine) header. For the patient dosimetry audit, current mean values of entrance surface dose (ESD) were compared with local and national reference values (RVs) for the specific examination type evaluated. Mean values exceeding the RV trigger an alarm signal and then an evaluation of the technical parameters, operational practice and image quality starts, using data available in the DICOM header to derive any abnormal settings or performance to obtain the image. the X-ray tube output for different kVp values is measured periodically, allowing for the automatic calculation of the ESD. The system also allows for image quality audit linking it with the dose imparted and other technical parameters if the alarm condition if produced. Results and advantages derived from this online quality control are discussed. (Author) 5 refs.

  5. Image and dose quality in selected studies of conventional radiology in designed hospitals; Calidad de imagen y dosis en estudios seleccionados de radiologia convencional en hospitales designados

    Energy Technology Data Exchange (ETDEWEB)

    Cardenas H, J.; Martinez G, A. [CPHR, Calle 20 No. 4113 e/41 y 47 Playa, C.P. 11300 La Habana (Cuba); Machado T, A.; Mora M, R. de la [Centro de Control Estatal de Equipos Medicos (Cuba); Pedroso, L. [Grupo Asesor del Ministerio de Salud Publica en materia de radiologia (Cuba); Villa Z, R. [Programa de Seguridad Radiologica del Ministerio de Salud Publica (Cuba); Sotolongo C, J.A.; Rodriguez S, R.M. [Hospital Universitario Clinico Quirurgico ' Luis Diaz Soto' (Cuba); Martinez A, U.; Figueroa G, L.M. [Hospital Universitario Clinico Quirurgico ' Miguel Enriquez' (Cuba)]. e-mail: cardenas@cphr.edu.cu

    2006-07-01

    The medical exposures have a significant contribution to the received doses by the population. As they generally contribute to the patient's direct benefit during a lot of time has been paid smaller attention that to other exposure forms, in spite of existing potentialities of reducing dose to the patients as consequence of these applications. In such sense in the last years the scientific community and international organizations have defined requirements to contribute to that the doses to the patients are the minimum ones necessary to achieve its diagnostic objective. The work exposes the results obtained in the evaluation of the image quality and dose in studies of radiology of thorax posteroanterior and of lumbosacral column anteroposterior and lateral, carried out in 2 university hospitals of La Havana, as well as the contribution of this investigation to the establishment of guidance levels in our country. (Author)

  6. Characterization of an absorbed dose standard in water through ionometric methods; Caracterizacion de un patron de dosis absorbida en agua mediante metodos ionometricos

    Energy Technology Data Exchange (ETDEWEB)

    Vargas V, M.X

    2003-07-01

    In this work the unit of absorbed dose at the Secondary Standard Dosimetry Laboratory (SSDL) of Mexico, is characterized by means of the development of a primary standard of absorbed dose to water, D{sub agua}. The main purpose is to diminish the uncertainty in the service of dosimetric calibration of ionization chambers (employed in radiotherapy of extemal beams) that offers this laboratory. This thesis is composed of seven chapters: In Chapter 1 the position and justification of the problem is described, as well as the general and specific objectives. In Chapter 2, a presentation of the main quantities and units used in dosimetry is made, in accordance with the recommendations of the International Commission on Radiation Units and Measurements (ICRU) that establish the necessity to have a coherent system with the international system of units and dosimetric quantities. The concepts of equilibrium and transient equilibrium of charged particles (TCPE) are also presented, which are used later in the quantitative determination of D{sub agua}. Finally, since the proposed standard of D{sub agua} is of ionometric type, an explanation of the Bragg-Gray and Spencer-Attix cavity theories is made. These theories are the foundation of this type of standards. On the other hand, to guarantee the complete validity of the conditions demanded by these theories it is necessary to introduce correction factors. These factors are determined in Chapters 5 and 6. Since for the calculation of the correction factors Monte Carlo (MC) method is used in an important way, in Chapter 3 the fundamental concepts of this method are presented; in particular the principles of the code MCNP4C [Briesmeister 2000] are detailed, making emphasis on the basis of electron transport and variance reduction techniques used in this thesis. Because a phenomenological approach is carried out in the development of the standard of D{sub agua}, in Chapter 4 the characteristics of the Picker C/9 unit, the ionization chamber type CC01, series 131, built by Osterreichisches Forschungszentrum Seibersdorf, and the experimental conditions are shown. The characteristics of the complementary instrumentation employed in the experimental part of the work, are also presented. In Chapter 5, two ionometric methods for the calculation of the correction factors are presented: that of the Bureau International des Poids et Mesures (BIPM) and that of the International Atomic Energy Agency (IAEA). In the BIPM method emphasis is made in the MC simulation of the spectral fluence of the photons that emits the unit (using a realistic geometry and an equivalent one) as well as its validation by means of the air-kerma output factors and the percent depth doses in water, with the aid of the condition of TCPE that apply to the CC01-131 chamber. In particular, it is presented how the factor k{sub cav} is determined, employing MC simulation of two positions of the chamber (with the chamber axis parallel or perpendicular to the beam axis), and by means of a semi-analytic approach that uses the energy dissipation functions of Spencer for the parallel position. Finally the factor k{sub p} is determined for both orientations. In the case of the IAEA method, the expressions of the correction factors in the protocols TRS-277 and TRS-398 are shown. Chapter 6 presents results and discussion, and Chapter 7 presents conclusions and recommendations. In Chapter 6, the protocol of the BIPM/ISO/TAG [ISO 1992] for the calculation of the uncertainties is detailed, later the results and its discussion is made. The main conclusion obtained of these results is that the value of the D{sub agua} and its U for the BIPM method is bigger than that for the IAEA method. This conclusion has at least three meanings: First: The correction factors calculated using the BIPM method are overestimated, regarding the IAEA method. Second: The possible overestimation is consistent with the order of uncertainty with which are calculated, that is with the infrastructure that at the moment the SSDL-Mexico possesses to carry out the unit of absorbed dose to water (instrumentation, traceability of the electrometers, barometers, thermometers, calculation algorithms, time of machine, etc). Third: In this work it was shown the necessity to solve, if it exists, the ambiguity [Alvarez et al. 2002] of the models of the IAEA and the BIPM methods, when applying them to the design of the CC01-131 chamber. It was determined that, within the order of uncertainty with which the correction factors and the D{sub agua} were obtained, none of the two models presents the problem of ambiguity. (Author)

  7. Dose distribution, using homogeneous material before the reload of the JS-6500 irradiator; Distribucion de dosis, empleando material homogeneo antes de la recarga del irradiador JS-6500

    Energy Technology Data Exchange (ETDEWEB)

    Carrasco A, H

    1991-10-15

    The objective of this report is to determine the dose distribution inside the aluminum containers used for the industrial irradiation, as well as to locate the positions of maximum and minimum doses, before the reloading of the JS-6500 Irradiator. (Author)

  8. MYDOZE: Application Web for management and optimisation of doses to patients in tests radiodiagnostics; MYDOZE: Aplicacion Web para gestion y optimizacion de dosis a pacientes en pruebas radiodiagnosticas

    Energy Technology Data Exchange (ETDEWEB)

    Peinado Zamora, A. B.; Laguna Lobato, M. A.; Gil Agudo, A.; Zapata Jimenez, J. C.

    2013-07-01

    The service of Radiofisica y Proteccion Radiologica del Hospital general Universitario de Ciudad Real, carried out a study whose objective is to optimize the dose to patients undergoing diagnostic scans with ionizing radiation. To address this task, is required a software tool that facilitates on the one hand the acquisition of dosimetric data acquired digital equipment and the other interface of exploitation of this data for statistics and analysis of these. the computer tool to develop should allow storing parameters with information demographic and dose of the patient in medical scans thanks to called DICOM medical image standard. (Author)

  9. Thyroid dose of I-131 absorbed by the internal organs of a pregnant woman; Dosis tiroidea de I-131 absorbida por los organos internos de una embarazada

    Energy Technology Data Exchange (ETDEWEB)

    Arcos P, A.; Manzanares A, E.; Vega C, H.R.; Leon, C.L. de [Cuerpo Academico de Radiobiologia de la Universidad Autonoma de Zacatecas (Mexico)]. e-mail: emanz_44@yahoo.com

    2007-07-01

    The use of nuclear techniques, for diagnosis or treatment, generates stress in the patient and its relatives. During the pregnancy some sufferings related with the thyroid gland can be presented. If the patient is pregnant, OEP or NOEP, the stress comes from the fear to that the product can it turns affected. The dose is calculated that the Iodine 131, captured by the thyroid of a woman with three months of pregnancy, it deposits in the brain, stomach, heart, kidneys, liver, lungs, ovaries, pancreas, thymus, spleen and in the uterus. The thymus is the organ that receives the biggest dose. (Author)

  10. Determination of effective dose in pediatric radiodiagnostic in Medellin-Colombia; Determinacion de la dosis efectiva en radiodiagnostico pediatrico en Medellin-Colombia

    Energy Technology Data Exchange (ETDEWEB)

    Garzon, William J., E-mail: wjaramig@gmail.com [Instituto Tecnologico Metropolitano (ITM), Medellin (Colombia); Aramburo, Javier M.; Jimenez, Angelmiro A.; Ortiz, Anselmo P., E-mail: jmorales@unal.edu.co, E-mail: aarrieta@unal.edu.co, E-mail: japuerta@unal.edu.co [Universidad Nacional de Colombia (UNAL), Medellin (Colombia)

    2013-10-01

    In order to know the effective dose in pediatric X-ray exams of chest, entrance surface dose measurements were performed for ages 1,5 and 10 years in the largest pediatric hospital in the city of Medellin, Colombia. The effective dose was obtained from applying the conversion coefficients to measures of the entrance surface dose (ESD) in 306 radiographic studies in AP and LAT I projections. The results were validated with PCXMC 2.0 computer program and other work reported in the literature. (author)

  11. Optimasi Suhu Aktivasi Dan Dosis Zeolit Sebagai Adsorben Seng Dan Besi Yang Terkandung Di Dalam Limbah Cair Industri Sarung Tangan Karet

    OpenAIRE

    Simangunsong, Vera

    2011-01-01

    The aplication of the activated natural zeolite sarulla to absorpt Zn and Fe in the wastewater of rubber glove industry have been carried out in various dose of absorbent , and activation temperature. Sample rubber glove industry wastewater was prepared with wet destuction methode, using concentrated of nitrit acid and perclorat acid.. The powder of 100 mesh activated zeolite was produced by heating the powder at 1000C, 1500, 2000, 2500C, 3000C, and 3500C for 3 hours, and various dose of zeol...

  12. Assessment of dose-volume histograms in brachytherapy 3D high-rate; Evaluacion de los histogramas dosis volumen en braquiterapia de alta tasa 3D

    Energy Technology Data Exchange (ETDEWEB)

    Gomez Barrado, A.; Tripero Oter, J.; Sanchez Jimenez, E.; Sanchez-Reyes, A.

    2013-07-01

    The use of systems of treatment planning using 3D reconstruction algorithms are becoming more frequent in brachytherapy treatments. The implementation of these systems entails great qualitative and quantitative procedural changes in the way to evaluate the clinical dosimetry about the 2D classical systems. This paper describes the experience of our Centre in employment and prescription dose using histograms dose-volume in the treatment of brachytherapy of high rate. (Author)

  13. Analysis of dose to crystalline in Interventional radiology: a purpose of one case; Analisis de dosis a cristalino en Radiologia intervencionista: a proposito de un caso

    Energy Technology Data Exchange (ETDEWEB)

    Carrera M, F.; Moreno R, F.; Velazquez M, F.; Manzano M, F.J.; Moreno S, T. [Hospital `Juan Ramon Jimenez` Ronda Norte s/n 21005. Huelva, Espana (Spain)

    1998-12-31

    The present work shows the dose values to crystalline for the personnel which works in interventional radiology procedures. It was took data of 436 studies with a total of 2,133.4 minutes in fluoroscopy and 19,563 images. It was showed dose values to crystalline in three situations: without blinding, with blinding of 0.25 and 0.50 mm Pb and by type of study: fluoroscopy, graphie and total. The dose means and ranges to patient for each of these studies also are detailed. (Author)

  14. Induction and transfer of resistance to poisoning by Amorimia pubiflora in sheep whith non-toxic dosis of the plant and ruminal content

    Directory of Open Access Journals (Sweden)

    Marciel Becker

    2016-04-01

    Full Text Available ABSTRACT: Amorimiapubiflora (Malpighiaceae, which contains sodium monofluoroacetate (MFA is the main cause of "sudden death" in cattle in the Brazilian state of Mato Grosso. This research investigated the induction of resistance to the poisoning in sheep by the continuous administration of non-toxic doses of the plant and also the possibility to transfer this resistance to other sheep by the transfaunation of ruminal fluid. For this a group of four sheep (G1 received daily doses of 0.5g kg-1 for 20 days and after an interval of 15 days were challenged with three daily doses of 1g kg-1 for 3 days. Also the transfer of resistance to A. pubiflora poisoning was evaluated by transfaunation of rumen fluid (100ml for 10 days from G1 sheep to five sheep (G2, followed by challenge with the dose of 1g kg-1 for 3 days (G2D2 and after a three-day interval they received a single dose of 3g kg-1 (G2D3. The degree of resistance was evaluated by monitoring the onset of clinical signs, heart rate, and outcome of the poisoning compared with the control groups, which were challenged with three daily doses of 1g kg1 (G3 and with a single dose of 3g kg-1 (G4. Clinical parameters evaluated in Groups G1 and G2 were significantly less pronounced than those observed in G3 and G4 (control (P<0.05. Sheep in G4 (control died after receiving a single dose of 3g kg-1, while those in G2 (transfaunated survived. These findings demonstrated that consumption of non-toxic doses of A. pubiflora induced resistance in sheep and that this resistance can be transferred by transfaunation. New experiments are needed to determine the most efficient ways to induce resistance and to use this technique in the field to prevent the poisoning.

  15. Commercial sugar, an alternative dosemeter for the dose determination in radiological emergency conditions; Azucar comercial, un dosimetro alternativo para la determinacion de dosis en situaciones de emergencia radiologica

    Energy Technology Data Exchange (ETDEWEB)

    Urena N, F.; Galindo, S. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    1997-07-01

    It was carried out the dosimetric evaluation of commercial sugar, with the purpose to determine the feasibility to be able to use this type of substance as a dosimetric material in cases to present some radiological emergency cases. The studied parameters using the Electron Paramagnetic Resonance (EPR) technique were: pre-doses signal or depth signal, dose-response stability, reproducibility, reliability and signal clearing decreasing. (Author)

  16. Systems automated reporting of patient dose in digital radiology; Sistema automatizado para generacion de informes de dosis a paciente en radiologia digital

    Energy Technology Data Exchange (ETDEWEB)

    Collado Chamorro, P.; Sanz Freire, C. J.; Martinez Mirallas, O.; Tejada San Juan, S.; Lopez de Gammarra, M. S.

    2013-07-01

    It has developed a procedure automated reporting of doses to patients in Radiology. This procedure allows to save the time required of the data used to calculate the dose to patients by yields. Also saves the time spent in the transcription of these data for the realization of the necessary calculations. This system has been developed using open source software. The characteristics of the systems of digital radiography for the automation of procedures, in particular the registration of dose should benefit from patient. This procedure is validated and currently in use at our institution. (Author)

  17. Determination of the dose index in computerized tomography using thermoluminescent dosemeters; Determinacion del indice de dosis en tomografia computada usando dosimetros termoluminiscentes

    Energy Technology Data Exchange (ETDEWEB)

    Azorin, J.C.; Calderon, A. [Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada-IPN, 11500 Mexico D.F. (Mexico); Azorin, J. [UAM-I, 09340 Mexico D.F. (Mexico)

    2004-07-01

    In this work the obtained results of the determination of the dose index are presented in thorax studies in computed tomography and helical tomography carried out in Mexico using thermoluminescent dosemeters of LiF: Mg,Cu,P + Ptfe developed and manufactured in our country. The results showed that under similar conditions of irradiation and operation (pitch = 1), significant differences don't exist among the doses absorbed measures in the phantom due to the two types of used tomographs. (Author)

  18. Dependence of 'CT clearance' on dosage and time. Die Dosis- und Zeitabhaengigkeit der 'CT-Clearance'

    Energy Technology Data Exchange (ETDEWEB)

    Kaltenborn, H.A.; Klose, K.J.; Dexheimer, C. (Mainz Univ. (Germany, F.R.). Inst. fuer Klinische Strahlenkunde); Steinijans, V. (Byk Gulden, Konstanz (Germany, F.R.). Abt. fuer Biometrie)

    1989-06-01

    The contrast medium dose used in CT renal function analysis corresponds to about 1 ml/kg body weight at a measurement interval of 5 or 10 minutes. In the present study the dependence of 'CT clearance' on dosage and time was examined in 12 healthy subjects. The amount of clearance was directly proportional to the employed contrast medium dose and to the length of the measurement interval. On account of the superior signal-to-noise ratio, the higher dose (1 ml/kg body weight) will continue to be prefered in future. The measurement interval can be limited to 10 minutes. (orig.).

  19. Kinetics of the early adaptive response and adaptation threshold dose; Cinetica de la respuesta adaptativa temprana y dosis umbral de adaptacion

    Energy Technology Data Exchange (ETDEWEB)

    Mendiola C, M.T.; Morales R, P. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    2003-07-01

    The expression kinetics of the adaptive response (RA) in mouse leukocytes in vivo and the minimum dose of gamma radiation that induces it was determined. The mice were exposed 0.005 or 0.02 Gy of {sup 137} Cs like adaptation and 1h later to the challenge dose (1.0 Gy), another group was only exposed at 1.0 Gy and the damage is evaluated in the DNA with the rehearsal it makes. The treatment with 0. 005 Gy didn't induce RA and 0. 02 Gy causes a similar effect to the one obtained with 0.01 Gy. The RA was show from an interval of 0.5 h being obtained the maximum expression with 5.0 h. The threshold dose to induce the RA is 0.01 Gy and in 5.0 h the biggest quantity in molecules is presented presumably that are related with the protection of the DNA. (Author) =.

  20. Dose optimization with cylinder vaginal/catheter intrauterine applicator of Gamma Med Plus; Optimizacion de dosis con aplicador cilindro vaginal/cateter intrauterino de GammaMed Plus

    Energy Technology Data Exchange (ETDEWEB)

    Laguardia, R. Alfonso; Patallo, I. Silvestre; Yip, F. Garcia [Instituto Nacional de Oncologia y Radiobiologia (INOR), La Habana (Cuba); Pena, P. Pacheco [OIEA, Havana (Cuba). Becario OIEA

    2004-07-01

    ABACUS is the computerize system that allows the planning of High Dose Rate (HDR) Brachytherapy treatments for Gamma Med Plus. The system provides multiple tools for dose optimization, some linked to the geometry of the applicators and others to optimization algorithms. The previous experience with HDR at the INOR had been with the Microselectron and the PLATO planning system. More than 30 years in application of the Low Dose Rate Brachytherapy with {sup 137} Cs sources and Fletcher type applicators in gynecological treatments and the good clinical results valued by the doctors gave the idea of optimizing the applications of HDR with Microselectron, making them equivalent to those of the Low Dose Rate. The new problem was related to the use of the applicator type Cylinder/Uterine probe for the treatment of cervix and cervix endometrial lesions due to the absence in our Institution of the Fletcher type for Gamma Med PLUS. We established the use of three Dose Reference Points (DRP): one equivalent to the point A and two in the positions corresponding to the place that would occupy the ovoid. Also we established the Dose Distance to the surface of the cylinder to achieve the similar shape of Pear on the 650 cGy Isodose to the one obtained with PLATO. We determine the use of Gamma Med PLUS and applicator Cylinder/Uterine probe in all those patients which anatomies allows the introduction of mini ovoid pair and intrauterine tube 15 deg or 30 deg. (author)

  1. Dosis Pupuk Cair Anorganik dan Jarak Tanam Berpengaruh terhadap Pertumbuhan dan Produksi Bawang Merah (Allium ascalonicum L. Var. TUK TUK) Asal Biji

    OpenAIRE

    Sembiring, Ferdinanta

    2011-01-01

    The influence of a combination of liquid fertilizer inorganic and plant spacing on growth and production of onion plants from seed have not yet researched in this area. For that one study has been conducted on community land Nibung Tumpan Village, Batang Kuis District, Deli Serdang (± 25 m asl.) In June - September 2009 using a random factorial design factor of 2 doses of inorganic liquid fertilizer (0, 1, 2, 3 cc / liter of water and NPK recommended dose) and spacing (5 x 10 cm, 1...

  2. Analysis of the doses used in procedures performed in an endoscopy unit; Analisis de las en dosis empleadas en procedimientos realizados en una Unidad de Endoscopias

    Energy Technology Data Exchange (ETDEWEB)

    Miquelez Alonso, S.; Bragado Alvarez, I.; Iriondo Igerabide, U.; Martin Albina, M. L.; Forner Forner, A.; Otal Palacin, A.; Soto Prados, P.; Maneru Camara, F.; Lozares Cordero, S.; Rubio Arroniz, A.; Pellejero Pellejero, S.

    2011-07-01

    There have been recording and analysis of the doses received by patients undergoing radiologic studies in an endoscopy unit and compared with data published by the National Radiological Protection Board (NRPB).

  3. Radiation doses in neuroangiography for a clinical hospital in Chile; Dosis de radiacion en neuroangiografia para un hospital clinico de Chile

    Energy Technology Data Exchange (ETDEWEB)

    Vergara, F.; Valenzuela, E., E-mail: franciscovergara@hotmail.com [Pontificia Universidad Catolica de Chile, Santiago (Chile). Facultad de Medicina. Centro de Terapia Endovascular; Ubeda, C.A.; Nocetti, D., E-mail: carlos.ubeda.uta@gmail.com [Universidade de Tarapaca (Chile). Centro de Estudos en Ciencias Radiologicas (CECRad). Dept. de Tecnologic Medica. Facultad de Ciencias de la Salud (FACSAL)

    2013-11-01

    The objective of this study is to estimate the levels of radiation to the patient in neuroangiography procedures diagnostic and therapy in a Chile's Hospital, using a biplane angiographic system Siemens model ArtisZee. This research was conducted under the auspices of the International Atomic Energy Agency and the support of their radiation protection programs for patients.

  4. Paradigm shift in LUNG SBRT dose calculation associated with Heterogeneity correction; Cambio de paradigma en SBRT pulmonar asociada al calculo de dosis con correccion de heterogeneidad

    Energy Technology Data Exchange (ETDEWEB)

    Zucca Aparicio, D.; Perez Moreno, J. M.; Fernandez Leton, P.; Garcia Ruiz-Zorrilla, J.; Pinto Monedero, M.; Marti Asensjo, J.; Alonso Iracheta, L.

    2015-07-01

    Treatment of lung injury SBRT requires great dosimetric accuracy, the increasing clinical importance of dose calculation heterogeneities introducing algorithms that adequately model the transport of particles narrow beams in media of low density, as with Monte Carlo calculation. (Author)

  5. Independent dose calculation of the Tps Iplan in radiotherapy conformed with MLC; Calculo independiente de dosis del TPS Iplan en radioterapia conformada con MLC

    Energy Technology Data Exchange (ETDEWEB)

    Adrada, A.; Tello, Z.; Medina, L.; Garrigo, E.; Venencia, D., E-mail: jorge.alberto.adrada@gmail.com [Instituto Privado de Radioterapia, Obispo Oro 423, X5000BFI Cordoba (Argentina)

    2014-08-15

    The systems utilization of independent dose calculation in three dimensional-Conformal Radiation Therapy (3D-Crt) treatments allows a direct verification of the treatments times. The utilization of these systems allows diminishing the probability of errors occurrence generated by the treatment planning system (Tps), allowing a detailed analysis of the dose to delivering and review of the normalization point (Np) or prescription. The independent dose calculation is realized across the knowledge of dosimetric parameters of the treatment machine and particular characteristics of every individual field. The aim of this work is develops a calculation system of punctual doses for isocentric fields conformed with multi-leaf collimation systems (MLC), where the dose calculation is in conformity with the suggested ones by ICRU Report No. 42, 1987. Calculation software was realized in C ++ under a free platform of programming (Code::Blocks). The system uses files in format Rtp, exported from the Tps to systems of record and verification (Lantis). This file contains detailed information of the dose, Um, position of the MLC sheets and collimators for every field of treatment. The size of equivalent field is obtained from the positions of every sheet; the effective depth of calculation can be introduced from the dosimetric report of the Tps or automatically from the DFS of the field. The 3D coordinates of the isocenter and the Np for the treatment plan must be introduced manually. From this information the system looks the dosimetric parameters and calculates the Um. The calculations were realized in two accelerators a NOVALIS Tx (Varian) with 120 sheets of high definition (hd-MLC) and a PRIMUS Optifocus (Siemens) with 82 sheets. 705 patients were analyzed for a total of 1082, in plans made for both equipment s, the average uncertainty with regard to the calculation of the Tps is-0.43% ± 2.42% in a range between [-7.90 %, 7.50 %]. The major uncertainty was in Np near of the MLC. The software checks the dose in any Np, helps to detect mistakes in the planning. Therefore, concludes that the calculation point should not be in semidarkness zones (near the MLC), because it is what causes the most uncertainty in the independent calculation. (author)

  6. Doses of radiation in the environment of patients undergoing treatment of ophthalmic brachytherapy; Dosis de radiaciones en el entorno de pacientes sometidos a tratamientos de braquiterapia oftalmica

    Energy Technology Data Exchange (ETDEWEB)

    Terron Leon, J. A.; Moreno Reyes, J. C.; Perales Molina, A.; Miras, H.; Ortiz, M.; Macias, J.

    2013-07-01

    This paper presents results for measures of dose made to different patient undergoing treatment with ophthalmic brachytherapy. The aim of these measures has been, on the one hand, verify assessments relating to radiation protection in the memory of the installation and, on the other hand, experimental measures that can serve to reduce the perception of the radiological risk professionals have. (Author)

  7. Measuring the absorbed dose in critical organs during low rate dose brachytherapy with {sup 137} Cs using thermoluminescent dosemeters; Medicion de la dosis absorbida en organos criticos durante braquiterapia de baja tasa de dosis con {sup 137} Cs usando dosimetros termoluminiscentes

    Energy Technology Data Exchange (ETDEWEB)

    Torres, A. [UAEM, Fac. de Medicina, 50180 Toluca, Estado de Mexico (Mexico); Gonzalez, P.R. [ININ, A.P. 18-1027, 11801 Mexico D.F. (Mexico); Furetta, C.; Azorin, J. [UAM-I, 09340 Mexico D.F. (Mexico); Andres, U.; Mendez, G. [Centro Estatal de Cancerologia de Tabasco, A. Gregorio Mendez No. 2838, Col. Atasta, 86100 Villahermosa, Tabasco (Mexico)

    2003-07-01

    Intracavitary Brachytherapy is one of the most used methods for the treatment of the cervical-uterine cancer. This treatment consists in the insertion of low rate dose {sup 137}Cs sources into the patient. The most used system for the treatment dose planning is that of Manchester. This planning is based on sources, which are considered fixed during the treatment. However, the experience has shown that, during the treatment, the sources could be displaced from its initial position, changing the dose from that previously prescribed. For this reason, it is necessary to make measurements of the absorbed dose to the surrounding organs (mainly bladder and rectum). This paper presents the results of measuring the absorbed dose using home-made LiF: Mg, Cu, P + Ptfe thermoluminescent dosimeters (TLD). Measurements were carried out in-vivo during 20 minutes at the beginning and at the end of the treatments. Results showed that the absorbed dose to the critical organs vary significantly due to the movement of the patient during the treatment. (Author)

  8. Control letters and uncertainties of the kerma patterns in air, dose absorbed in water and dose absorbed in air of the LSCD; Cartas de control e incertidumbres de los patrones de kerma en aire, dosis absorbida en agua y dosis absorbida en aire del LSCD

    Energy Technology Data Exchange (ETDEWEB)

    Alvarez R, M.T.; Tovar M, V.M.; Cejudo A, J. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)

    2005-12-15

    With the purpose of characterizing the component of uncertainty of long term of the patron ionization chambers of the LSCD, for the magnitudes: speed of kerma in air {kappa}{sub {alpha}}{sub {center_dot}}, dose speed absorbed in water D{alpha}{sub {center_dot}}, and speed absorbed dose in air D{alpha}{sub {center_dot}}, it use the technique of letters of control l-MR/S. This statistical technique it estimates the component of uncertainty of short term by means of the deviation standard inside groups {sigma}{sub {omega}} and that of long term by means of the standard deviation among groups {sigma}{sub {beta}}, being this it finishes an estimator of the stability of the patterns.The letters of control l-MR/S it construct for: i) {kappa}{sub {alpha}}{sub {center_dot}}, in radiation field of {sup 60}Co for patterns: primary CC01 series 131, secondary NE 2611 series 176, secondary PTW TN30031 series 578 and Third PTW W30001 series 365. ii) D{alpha}),en radiation field of {sup 60}Co for patterns: primary CC01 series 131, Secondary PTW TN30031 series 578 and tertiary PTW W30001 series 365. iii) I-MR/S with extrapolation chamber PTW primary pattern, measurement realizes in secondary patron fields of {sup 90}Sr-{sup 90}Y. The expanded uncertainty U it is calculated of agreement with the Guide of the ISO/BIPM being observed the following thing: a. In some the cases {sigma}{sub {beta}}, is the component of the U that more contributed to this. Therefore, it is necessary to settle down technical of sampling in those mensurations that allow to reduce the value of {sigma}{sub {beta}}. For example with sizes of subgroup {eta}{sub {approx}} 30 data, or with a number of subgroups {kappa}{sub {>=}}. That which is achieved automating the mensuration processes. b.The component of the temperature is also one of those that but they contribute to the U, of there the necessity of: to recover the tracking for this magnitude of it influences and to increase the precision in the determinations of the temperature to diminish their influence in the U. c. The percentage difference of the magnitudes dosemeters carried out by it patterns are consistent with U certain. However, it is necessary to diminish the uncertainty in the physical factors different to {kappa}{sub {tau}} and {sigma}{sub {beta}} for the one case of the primary patterns; because these they should be those of smaller value of U. d. In the case of the secondary patterns and tertiary for the realization of the{kappa}{sub {alpha}}{sub {center_dot}} is necessary to determine the corrections explicitly for recombination and polarization; and to analyze their contribution in the U. e. It is necessary to recover the tracking for the mensurations of the humidity. f. It is recommended to continue the control mensurations for each pattern, taking it{sup s} the least a measure every fifteen days, that it corresponds at two measured for month and 24 at the year. g. The operation of the air conditioned perturb the measurement for such as it recommends not to use it, and alone to leave in balance the chamber with the air of the engine room. (Author)

  9. Efecto de la escarificación y la dosis del ácido giberélico (AG3) en la germinación de semilla de curuba (Passiflora mollisima) Efecto de la escarificación y la dosis del ácido giberélico (AG3) en la germinación de semilla de curuba (Passiflora mollisima)

    OpenAIRE

    Cardozo Gutiérrez Rito Hernán

    1988-01-01

    The trials made on banana passion fruit seeds germination (Passiflora mollisima(HBK) Bailey, under laboratory specifications show that the testa delays the water absortion and it is the critic factor on the germination. AG3 increases the germination remarkably and strengthens the effects of the scarification considerably.

    Los ensayos de la germinación de semilla de curuba (Passiflora mollisima (HBK) Bailey en condiciones de ...

  10. Efecto de la escarificación y la dosis del ácido giberélico (AG3 en la germinación de semilla de curuba (Passiflora mollisima Efecto de la escarificación y la dosis del ácido giberélico (AG3 en la germinación de semilla de curuba (Passiflora mollisima

    Directory of Open Access Journals (Sweden)

    Cardozo Gutiérrez Rito Hernán

    1988-06-01

    Full Text Available

    The trials made on banana passion fruit seeds germination (Passiflora mollisima(HBK Bailey, under laboratory specifications show that the testa delays the water absortion and it is the critic factor on the germination. AG3 increases the germination remarkably and strengthens the effects of the scarification considerably.

    Los ensayos de la germinación de semilla de curuba (Passiflora mollisima (HBK Bailey en condiciones de laboratorio, muestran que la testa retarda la absorción del agua y es el principal factor de control de la germinación. El ácido giberélico aplicado incrementa la germinación y refuerza considerablemente los efectos de la escarificación.

  11. Evaluation of the integral and Peripheral dose of healthy tissue in external radiotherapy treatments of prostate cancer with technical 3DCRT, reverse IMRT and VMAT; Evaluacion de la dosis integral y dosis periferica del tejido sano en tratamientos de radioterapia externa de cancer de prostata con tecnicas de 3DCRT, IMRT inversa y VMAT

    Energy Technology Data Exchange (ETDEWEB)

    Vicente Granado, D.; Carrasco Herrera, M. A.; Mateo Perez, C.; Velazquez Miranda, S.; Herrador Cordoba, M.

    2013-07-01

    To model and validate, in the system of planning and calculation Pinnacle, a micro-multilayers collimator mounted on an accelerator Siemens Primus. The objective is to take advantage of the improvements offered by the algorithm of convolution of cone collapsed and the capacity of the system of modeling the rounded end of the blades. (Author)

  12. Evaluation of dose-volume histogram parameters (V20 and mean dose) in lung cancer adaptive radiotherapy with design of composite lung volumes (ITV; Evaluacion de parametros del histograma dosis-volumen (V20 y dosis media) en radioterapia adaptada de cancer de pulmon con diseno de volumenes pulmonares compuestos (Internal Target Volume, ITV)

    Energy Technology Data Exchange (ETDEWEB)

    Monroy Anton, J. L.; Solar Tortosa, M.; Lopez Munoz, M.; Navarro Bergada, A.; Estornell gualde, M. A.; Melchor Iniguez, M.

    2013-07-01

    Physiological respiratory motion is a challenge in external radiotherapy for lung tumors. In adaptive radiotherapy, changing position of the target volume should be reflected in the simulation procedure and taken into account in the design of volumes for CTV/PTV proper coverage. This may be achieved through the design of an Internal Target Volume (ITV) as indicated in ICRU-62. However, the Dose-Volume Histogram (DVH) evaluation of the doses received by the healthy lung may vary in the case of designing a single lung volume, compared to the composite lung volume obtained with the fusion of normal breathing, inspiration and expiration (ITV{sub l}ung). (Author)

  13. Evaluation of absorbed dosis during studies of renal function due AI {sup 123}I / {sup 131}I (Hippuran) and {sup 111} In (DPTA); Evaluacion de la dosis absorbida durante estudios de la funcion renal debido AI I{sup 123} / I{sup 131} (Hippuran) E In{sup 111} (DPTA)

    Energy Technology Data Exchange (ETDEWEB)

    Arteaga, Marcial V.V.; Diestra, Carlos E.C.; Villanueva, Raul A.S.; Alegria, Roberto R.; Salvatierra, Carlos C.; Rosales, Jorge M.; Gonzalez, Denis A.; Cruz, Carlos A.M., E-mail: marvva@hotmail.com [Universidad Nacional de Trujillo (UNT), Trujillo (Peru). Fisica Medica; Rios, Edulfo E.D., E-mail: ediaz@ufrgs.br [Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS (Brazil)

    2014-07-01

    Using the MIRD methodology and Cristy-Eckerman representation for for adult kidneys, it proves that the dosimetric contributions of bodies of the biokinetics of {sup 123} I / {sup 131}I (Hippuran) and {sup 111}In (DTPA) are significant, in the estimated of dose, during studies of renal function. Dosimetric contributions (whole body and urinary bladder, kidney excluding) are given by 11.90% (for {sup 123}I), 4.97% (for {sup 131}I) and 28.32% (for {sup 111} In). In all cases, the dosimetric contributions are mainly due to photons emitted by the entire body.

  14. Dose preparatória versus injeção única: estudo comparativo entre diferentes doses de cisatracúrio Dosis preparatoria versus inyección única: estudio comparativo entre diferentes dosis de cisatracúrio Priming versus bolus: a comparative study with different cisatracurium doses

    OpenAIRE

    Angélica de Fátima de Assunção Braga; Glória Maria Braga Potério; Franklin Sarmento da Silva Braga; Eugesse Cremonesi; Francisco Pena Siqueira; Vanessa H Carvalho

    2003-01-01

    JUSTIFICATIVA E OBJETIVOS: A técnica da dose preparatória é uma alternativa para encurtar o tempo de latência dos bloqueadores neuromusculares adespolarizantes. O objetivo deste estudo foi avaliar o tempo para instalação do bloqueio neuromuscular máximo, as condições de intubação traqueal e as alterações cardiocirculatórias ocasionadas por diferentes doses de cisatracúrio em injeção única e em doses fracionadas. MÉTODO: Foram estudados 80 pacientes, estado físico ASA I e II, distribuídos em d...

  15. Necessidade de cuidados de enfermagem e intervenções terapêuticas em UTI: estudo comparativo entre pacientes idosos e não idosos Necesidades de cuidados de enfermeria e intervenciones terapeuticas en la Unidad de Cuidados Intensivos: estudio comparativo entre pacientes ancianos y no ancianos Nursing care need and therapeutics interventions in Intensive Care Unit: a comparative study among elderly and non-elderly patients

    Directory of Open Access Journals (Sweden)

    Juliana Trench Ciampone

    2006-03-01

    Full Text Available OBJETIVOS: comparar as necessidades de cuidados de enfermagem e as intervenções terapêuticas realizadas em pacientes idosos e não idosos em UTI, segundo o Nursing Activities Score (NAS. MÉTODOS: Compuseram a amostra, 50 pacientes adultos admitidos na UTI de um Hospital Universitário do município de São Paulo, a partir de 26 de setembro de 2003. O teste de Mann-Whitney foi utilizado para a comparação entre as variáveis. RESULTADOS: Da amostra de pacientes, a média de idade foi de 70 anos. O mais freqüente tipo de tratamento foi clínico (78,0%, observando-se uma média de permanência de 3,5 dias e mortalidade de 38,0%. A pontuação média NAS foi de 66,57% (+ 9,15 permanecendo acima de 60,0% durante o período analisado. Não se observou diferença na média NAS de pacientes idosos (66,44% e não idosos (66,33%, assim como não houve diferença entre as intervenções terapêuticas realizadas nos dois grupos de pacientes. CONCLUSÃO: Os resultados mostram a necessidade de discussões sobre a indicação de UTI, frente às implicações éticas, econômicas e sociais inerentes à assistência intensiva.OBJETIVOS: comparar las necesidades de cuidados de enfermería y las intervenciones terapéuticas realizadas en pacientes adultos mayores y no adultos mayores en la UCI, según el Nursing Activities Score (NAS. MÉTODO: Hicieron parte de la muestra, 50 pacientes adultos admitidos en la UCI de un Hospital Universitario del municipio de Sao Paulo, a partir del 26 de setiembre del 2003. El NAS fue aplicado diariamente totalizando 339 medidas. Fueron considerados como adultos mayores los pacientes con edad igual o superior a 60 años. El test de Mann-Whitney fue utilizado para la comparación entre las variables. RESULTADOS: De la muestra de pacientes, el promedio de edad fue de 70 años. El tipo más frecuente de tratamiento fue el clínico (78,0%. Se observó un promedio de permanencia de 3,5 días y una mortalidad de 38,0%. La puntuación promedio NAS fue de 66,57% (+ 9,15 manteniéndose sobre el 60,0% durante el período analizado. No se observó diferencia en el promedio NAS de pacientes adultos mayores (66,44% y no adultos mayores (66,33%. De esta forma, no hubo diferencia entre las intervenciones terapéuticas realizadas en los dos grupos de pacientes. CONCLUSION: Los resultados muestran la necesidad de discusiones sobre la indicación de la UCI, frente a las implicaciones éticas, económicas y sociales inherentes a la atención intensiva.OBJECTIVES: To compare nursing care needs and therapeutic interventions of elderly and non-elderly patients admitted to an ICU. METHODS: The sample consisted of 50 adult patients from a university hospital in the district of São Paulo. Data were collect with the Nursing Activity Scale (NAS from September 26, 2003. The NAS was applied daily, from the time of admission to and discharge from the ICU, with a total of 339 measurements. Patients with 60 years of age or older were considered elderly patients. Data were analyzed with descriptive statistics and Mann-Whitney tests. RESULTS: The mean age of the patient sample was 70 years and the most frequent type of treatment was clinical (78.0%. The mean stay was 3.5 days and the mortality rate was 38.0%. The mean score for NAS was 66.57% (+ 9.15 and remained above the 60.0% mark for the entire period analyzed. No difference was observed between the mean NAS scores for elderly (66.44% and nonelderly (66.33% patients. And, there was no difference between the therapeutic interventions carried out in the two groups of patients. CONCLUSIONS: The results show the need for further discussion about the criteria for admission in ICU regarding the ethical, social, and economic implications of intensive care.

  16. Administración oral de preparado parenteral de vitamina K en anticoagulación excesiva por warfarina Oral administration of intravenous preparation of Vitamin K for excessive anticoagulation due to warfarin

    Directory of Open Access Journals (Sweden)

    Yoleima Lozada

    2012-04-01

    Full Text Available La warfarina es frecuentemente usada en la terapia anticoagulante actual, su acción debe ser monitorizada usando el tiempo de protrombina expresado como International Normalized Ratio (INR; cuando se excede el rango de seguridad se puede administrar vitamina K (Vit-K, preferentemente por vía oral. Dicha presentación no está disponible en Venezuela. Se realizó un ensayo clínico, doble ciego, donde a 20 pacientes, edad 18-60 años, sin sangrado e INR inicial de 6 a 10 inclusive; les fue suspendida la warfarina e inmediatamente agrupados al azar a recibir dosis única de Vit-K (oral 1.25mg de Vit-K fraccionada de una presentación parenteral o placebo. El punto final primario, INR Anticoagulation therapy with warfarin, a common clinical practice, needs to be monitored using protombine time expressed as the International Normalized Ratio (INR; when safety range is exceeded, Vitamin K (Vit-K could be administered with preference orally. In Venezuela the specific oral preparation for Vit-K is not available. This is a double blinded, randomized, placebo controlled, clinical trial; 20 patients, age 18-60 year with initial INR ≥ 6, ≤10, were randomized to oral Vit-K 1.25mg (prepared from intravenous presentation or placebo plus withholding warfarin. INR < 3.5 at 24 hours of treatment (the primary end point was achieved by 70% among Vit-K, and 20% among placebo patients; given an absolute risk reduction (ARR, of 50% (CI95%: 14.4-85.6 ρ = 0.028, NNT 2 (CI95%: 1.3 - 6.9. No adverse events were recorded including INR < 2 at 24 hours of treatment administration. Our results are consistent with studies where specific oral presentation of Vit-K was used. The results indicate that oral administration of Vit-K, prepared from an intravenous Vit-K preparation, is safe and more effective to revert excessive anticoagulation than simply withholding warfarin, in places where specific preparation of oral Vit-K is not available or too expensive.

  17. Infusión intermitente de inotrópicos en la insuficiencia cardíaca avanzada

    Directory of Open Access Journals (Sweden)

    Héctor O Ventura

    2001-08-01

    Full Text Available Es conveniente seleccionar adecuadamente a los pacientes en los que se administrará terapia con agentes inotrópicos. Se deben descartar potenciales causas reversibles de insuficiencia cardíaca y evaluar factores que puedan precipitar una descompensación. Los pacientes deben estar tratados con dosis máximas de medicamentos convencionales. Los niveles electrolíticos, especialmente potasio y magnesio deben ser controlados periódicamente con el fin de evitar arritmias, manteniendo el potasio por encima de 4mEq/L y el magnesio por encima de 2mEq/L, y evitar que los niveles de digoxina sean mayores de 2ng/dl. Deben seguir adecuadamente las instrucciones médicas y ser dotados de una educación adecuada acerca de su enfermedad junto con sus familiares cercanos. En conclusión, las indicaciones para el uso de agentes inotrópicos en el tratamiento de insuficiencia cardíaca avanzada deberían estar limitadas a: 1. Pacientes que estén en espera de trasplante cardíaco en los que se pueda utilizarlos como un puente hasta que sean trasplantados. 2. Se puede utilizarlos a corto plazo después de cirugía cardíaca para dar un soporte adecuado, hasta que el corazón del paciente comience a funcionar adecuadamente. 3. Como ya hemos discutido extensamente, se pueden utilizar en pacientes con insuficiencia cardíaca inestable y refractaria, como un puente hacia el uso de beta bloqueantes. 4. En pacientes con descompensación aguda. 5. Finalmente se deberían utilizar en pacientes con insuficiencia cardíaca avanzada y que no son candidatos a trasplante cardíaco, en los cuales es indispensable brindarles una calidad de vida mas digna. Idealmente, deben ser los pacientes los que escojan entre un tipo de medicamento que puede mejorar sus síntomas, pero a expensas de una disminución de su sobrevida. Es decir, poder escoger entre calidad versus cantidad.

  18. RUOLO DELL'IMAGING DI PERFUSIONE NELLA VALUTAZIONE DEI GLIOMI CEREBRALI

    OpenAIRE

    Tortora, Fabio

    2009-01-01

    Il ruolo dell’imaging di perfusione (PWI) nella caratterizzazione dell’eterogeneità emodinamica dei gliomi cerebrali e dei tessuti circostanti, e nella differenziazione dei gliomi di alto grado da quelli di basso grado. L’impostazione terapeutica e la prognosi dipendono dalla accurata distinzione tra tumori di alto e di basso grado, e sono state proposte diverse modalità di imaging per permettere l’accurata identificazione del grado di malignità

  19. Avaliação da integridade das células-tronco mesenquimais derivadas do tecido adiposo humano após o bioprocesso de criopreservação

    OpenAIRE

    Irioda, Ana Carolina

    2012-01-01

    Resumo: As celulas-tronco de origem adulta surgem como promessa terapeutica na medicina regenerativa podendo ser encontradas em diversos tecidos como o adiposo. Com as perspectivas da criacao de um banco de celula-tronco para pesquisa e posterior uso terapeutico, o estudo da criopreservacao dessas celulas urge, a fim de garantir que essas celulas apos o descongelamento permanecam viaveis e funcionais. Objetivos: Comparar as celulas-tronco do tecido adiposo antes da criopreservacao e apos o se...

  20. ‘PROBIOTIC BACTERIA ADMINISTRATION AS AN IMMUNOMODULATORY APPROACH FOR FOOD ALLERGY TREATMENT: PRECLINICAL STUDIES IN MOUSE MODELS’

    OpenAIRE

    Schiavi, Elisa

    2013-01-01

    Studi clinici ed epidemiologici hanno messo in evidenza l’associazione tra l’aumentata prevalenza delle malattie allergiche nei Paesi occidentali e la ridotta esposizione ai germi e/o l’ alterazione delle comunità microbiche intestinali, il cui metabolismo e composizione risultano cruciali per lo sviluppo e il mantenimento delle funzioni immunitarie. Riportare all’equilibrio il microbioma intestinale potrebbe rappresentare una strategia preventiva e/o terapeutica per le allergie, in particola...

  1. Avaliação da senescência celular em melanócitos e células de melanoma pela ação do oxigênio molecular singlete

    OpenAIRE

    Arruda, Gisele

    2011-01-01

    Resumo: Senescencia celular e um processo natural caracterizado principalmente pela parada do crescimento, enquanto que as celulas cancerosas proliferam indefinidamente. Entretanto, descobertas recentes mostraram que celulas de melanoma podem ainda sofrer senescencia induzida por oncogenes ou pelo estresse. Considerando-se que a senescencia pode tambem ser explorada como uma estrategia terapeutica m pacientes com melanoma, o nosso principal objetivo foi investigar o papel do oxigenio molecul...

  2. El modelo de trabajo en equipo

    OpenAIRE

    Iñaki Rodríguez Cueto

    2008-01-01

    El modelo de trabajo en equipo constituye una herramienta basica en cualquier organizacion que quiera conseguir los objetivos propuestos y, ademas, lo quiera conseguir dentro de parametros de eficacia y calidad.En el entorno de la Comunidad Terapeutica cobra mayor importancia el dominio de saber trabajar en equipo debido a la necesidad de conjugar aspectos psico-terapeuticos, educativos, medicos e, incluso, administrativos a la hora de planificar el tratamiento a nivel grupal e individual.El ...

  3. Micrometer-scale systems for regenerative medicine applications

    OpenAIRE

    Toppazzini, Mila

    2010-01-01

    La medicina rigenerativa applicata al campo ortopedico è considerata una possibile opzione terapeutica per la riparazione del tessuto osseo danneggiato. Si stanno studiano e sviluppando una gran varietà di sostituti ossei sintetici come valida alternativa agli innesti di tipo tissutale. Lo scopo di questo lavoro di tesi è la progettazione e lo sviluppo di un materiale iniettabile per il riempimento dei difetti ossei. In particolare abbiamo sviluppato un riempitivo composito iniettabile usa...

  4. Evaluación de la toxicidad aguda oral e irritación sobre mucosa bucal de la solución CM-95 tratada magnéticamente Oral acute toxicity and irritation on buccal mucosa evaluation of the CM-95 solution magnetically treated

    Directory of Open Access Journals (Sweden)

    Jorge Díaz Bestard

    2008-12-01

    Full Text Available La Solución CM-95 tratada magnéticamente es un producto en desarrollo que mostró propiedades inmunoestimulantes en ensayos preclínicos, característica que la hacen adecuada como candidata a inmunopotenciador. En este trabajo se evaluaron los posibles efectos tóxicos preclínicos de la Solución CM-95 tratada magnéticamente, por el método de las Clases de Toxicidad Aguda y el de irritación de la mucosa oral, adaptando las normas OECD 423 y la ISO 10993-10, respectivamente. En el método de las Clases de Toxicidad Aguda se utilizó el ensayo límite, en ratas Sprague Dawley hembras, en el cual la dosis estuvo relacionada con el nivel de inducción magnética, en este caso 0,16 T, aplicado a la Solución CM-95; y el volumen a administrar de la misma, calculado sobre la base de 2 ml de la solución por 100 g de peso corporal. La determinación de la irritación de la mucosa oral se llevó a cabo en hámster Sirios Dorados hembras mediante un ensayo a dosis repetidas durante 7 días de tratamiento en la bolsa gular derecha, con pellet de algodón impregnado con 0,5 ml de la solución tratada magnéticamente con la misma inducción. No se encontró mortalidad ni evidencias de signos tóxicos para el ensayo de toxicidad aguda, y se obtuvo un índice de irritación sobre mucosa oral de 0, por lo que la sustancia estudiada se enmarcó como "No clasificada" y "No irritante" según la metodología empleada. Estos resultados complementarán otros estudios toxicológicos para avalar la seguridad de esta Solución para su uso futuro como fármaco por vía oral.CM-95 solution magnetically treated is a product which showed immunologic properties in preliminary tests, characteristic that makes it adequate as inmunopotentiator candidate. In this study the possible preclinical toxic effects of CM-95 Solution magnetically treated were evaluated, by the Acute Toxicity Class method and oral mucosa irritation test, adapting guideline OECD 423 and ISO 10993

  5. Ketofol: ensayo clínico prospectivo aleatorizado en el Hospital Universitario del Caribe

    Directory of Open Access Journals (Sweden)

    Llamas William

    2011-09-01

    Full Text Available INTRODUCCIÓN: el ketofol es una combinación de dos anestésicos endovenosos: ketamina y propofol. Ambos son excelentesmedicamentos para inducir un estado de inconsciencia que provee las condiciones que el cirujano necesita para realizarprocedimientos quirúrgicos cortos, mínimamente invasivos. La ventaja de esta combinación es la potenciación de sus efectosanestésicos y la paliación mutua de sus efectos adversos; la hipotensión y depresión respiratoria inducidos por el propofol soncontrarrestados por la ketamina, así como los sueños vividos y reacciones de emergencia de la ketamina disminuyen dramáticamentecon propofol.HIPÓTESIS: en razón a que trabajos previos han mostrado que la mezcla ketamina/propofol en una mezcla 1:1(1 miligramo de ketaminapor cada miligramo de propofol es eficaz para proveer anestesia pero con efectos adversos tales como agitación, náuseas, reaccionesde emergencia, etc., creemos que la mezcla 1:2 (1 miligramo de ketamina por cada 2 miligramos de propofol proveerá igual estabilidadde las variables fisiológicas básicas durante la cirugía, con menor incidencia de eventos adversos (las dosis a suministrar están dentrodel rango de dosis considerados como seguros individualmente.METODOLOGÍA: estudio prospectivo aleatorizado a realizarse en el Hospital Universitario del Caribe, con pacientes entre 18 y 50 años,hombres y mujeres, a quienes se les vaya a someter a uno de los siguientes procedimientos: reducción de luxaciones; reducción defracturas; lavados desbridamientos de úlceras, pies diabéticos, y drenaje de abscesos; retiro de material de osteosíntesis;toracostomias; legrados uterinos; sutura de tejidos blandos; cuidados de quemaduras; herniorrafia umbilical; circuncisión y otrosprocedimientos de no más de una hora de duración. Los pacientes se asignarán aleatoriamente a dos grupos: 1. Ketamina/propofol enuna mezcla 1:1 (1 miligramo de ketamina por cada miligramo de propofol, y 2. Ketamina

  6. Estimation of delivered doses to the fetus in a external radiation therapy treatment of megavoltage; Estimacion de dosis impartida al feto en un tratamiento de radioterapia externa de megavoltaje

    Energy Technology Data Exchange (ETDEWEB)

    Ruggeri, Ricardo M.; Mairal, Liliana, E-mail: ricardoruggeri@gmail.com [Centro Medico Mevaterapia, Buenos Aires (Argentina); Scarabino, Mara L.; Colombo, Soledad; Sardi, Mabel, E-mail: maliscarabino@gmail.com [Hospital Italiano de Buenos Aires (Argentina)

    2013-11-01

    This work, stimulated by the entrance to our radiotherapy service several cases of central nervous system injury in pregnant patients, involves the estimation of doses to the fetus from the comparative analysis and verification of theoretical and experimental data. Um phantom was designed with the pregnant morphology about 28 weeks gestation, with inserts for waterproof ionization chamber in the head and abdominal area. From the scan of the anthropomorphic phantom were reproduced in 3D planner treatments comprised of pregnant patients, estimating the dose in the lesion and at different points in the abdominal area. With the phantom in the beam of radiation treatment conditions were measured with the camera dose at the same points of the abdomen mentioned and the isocenter of the injury. The dose was also measured on surface of the abdominal area with diode array to establish correlation with the measured dose ionization chamber calibrated with water. The work provided medical radiotherapists fundamental experimental data for elevated risk assessment framework for radiation protection of the fetus. It also set the reference calibration for in vivo dosimetry in the abdominal area in pregnant patients treated for external radiotherapy. The results obtained with the implemented dosimetry design will determine the procedures that will form the operating rules institution and thus how professionals working within it.

  7. Intercomparison of dispersed radiation readings among film dosimetry, electronic and OSL with X-rays for low dose; Intercomparacion de lecturas de radiacion dispersa entre dosimetria film, electronica y OSL con rayos X para dosis bajas

    Energy Technology Data Exchange (ETDEWEB)

    Andisco, D. [Universidad de Buenos Aires, Facultad de Medicina, Paraguay 2155, C1121AAA Buenos Aires (Argentina); Blanco, S. [CONICET, Saavedra 15, C1083ACA Buenos Aires (Argentina); Bourel, V.; Schmidt, L. [Universidad Favaloro, Facultad de Ciencias e Ingenieria, Solis 453, C1078AAI, Buenos Aires (Argentina); Di Risio, C., E-mail: dandisco@fmed.uba.ar [Universidad de Belgrano, Facultad de Ingenieria, Zabala 1837, C1426DQG, Buenos Aires (Argentina)

    2014-08-15

    One of the personal dosimetry methods more used for several decades is the dosimetry type film, characterized to possess readings with certain margin of trust. Today other methods exist that many times are presupposed more reliable due to the nature of the detection like the electronic dosimeters or the OSL (Optically Stimulated Luminescence) dosimetry. With the purpose of comparing different methods and to can determining the existent differences among each method has been carried out an intercomparison assay. The different dosimeters have been exposed to dispersed radiation generated by a Hemodynamics equipment of the type -arch in C- and a dispersing system of the primary beam. Film dosimeters have been used; OSL (In Light), OSL (Nano Dots) and Electronic with the purpose of knowing and to valorize the existent differences among its readings. Always, the intercomparison exercises have demonstrated to be an useful tool when establishing the measurement capacity and the quality of the results emitted by the laboratories of personal dosimetry services. Also, this type of assays allows obtaining quality indicators of the laboratory performance and they are habitual part of the procedures for accreditation of the same ones. The Optically Stimulated Luminescence is a technology that has grown in Argentina so much in the area of personal dosimetry as in dosimetry in vivo (radiotherapy area). In this intercomparison study, the answers corresponding to each technology were looked for oneself irradiation of the disperse type, that is to say, of very low energy. (Author)

  8. Determination of radiation-induced DNA double-strand breaks for the biological dose monitoring in cardiac computerized tomography; Bestimmung von strahleninduzierten DNA-Doppelstrangbruechen zum Monitoring der biologischen Dosis in der Herz-Computertomographie

    Energy Technology Data Exchange (ETDEWEB)

    Wegener, Jasmin

    2013-11-12

    Background and aims: X-rays cause relevant DNA damage to cells. DNA double-strand breaks (DSBs) are considered to be the most biologically significant radiation induced DNA-lesions. Recently a sensitive immunofluorescence microscopic method was developed to quantify x-ray induced DSBs as nuclear foci, even after doses as used in computed tomography. The method is based on the phosphorylation of the histone variant H2AX after formation of DSBs and distinct foci representing DSBs can be visualised. The number of foci correlates well with the delivered radiation dose. The importance of cardiac CT has increased during the last years. The radiation exposure of cardiac CT is rather high compared to other radiologic diagnostic procedures and techniques for dose-reduction receive increasing attention. In this context the purpose of this study was to determine to what extent the γ-H2AX-based method is able to measure x-ray induced DSBs in patients undergoing cardiac CT. Furthermore the objective was to evaluate whether CT-induced DSBs correlate with exposure parameters (dose length product, DLP) and to assess the influence of the scan protocols on the biological radiation damage. Materials and methods: 32 patients undergoing coronary CT angiography either using a 64-slice (n = 5: SOMATOM Sensation 64 {sup registered}) or a dual-source CT scanner (n = 27: SOMATOM Definition {sup registered}) were included in the study. Venous blood samples were taken before and 0.5 h, 2.5 h, and 24 h after the CT scan. Additional venous blood samples obtained before CT were irradiated in-vitro at various radiation doses (10 mGy, 50 mGy, 100 mGy) to obtain reference values of foci. Lymphocytes were separated and incubated with a specific γ-H2AX primary and a fluorescent secondary antibody. The number of γ-H2AX-foci was quantified using a fluorescence microscope. Every distinct focus represents one DNA-DSB. The number of radiation-induced DSBs was calculated by subtracting the foci number of corresponding non-irradiated control samples (baseline) from excess foci after exposure. The radiation dose to the blood was determined by comparing the number of CT-induced in-vivo DSBs with in-vitro DSB levels. Individual DLP was registered as provided by the patient protocol. Results: In all patients an increase of DSB values after CT was found (median: 0.36; range: 0.15-0.71 DSB/cell). Over a period of 24 hours a rapid reduction of DSBs due to DNA repair was observed and the baseline value of pre-exposure samples is nearly reached after 24 h. The number of radiation-induced DSBs (ρ = 0.57; p < 0.01) and the resulting radiation dose to the blood (ρ = 0.66; p < 0.01) showed a significant linear correlation to the dose length product. The radiation dose to the blood did not significantly differ between the two CT scanners used in this study if results are normalized to the individual DLP (SOMATOM Sensation 64 {sup registered}: 30 mGy/1000 mGy x cm; SOMATOM Definition {sup registered}: 27 mGy/1000 mGy x cm). An additional scan for calcium scoring led to a significant 21% increase of foci (p = 0.04). A reduction of the tube voltage (100 kV vs. 120 kV) resulted in a lower DLP (44%) and radiation dose to the blood (36%) but these differences were not significant (DLP: p = 0.40; radiation dose to the blood: p = 0.44). The dose reducing effect of a higher pitch used in patients with higher heart rates was mitigated by a broader window (40-70% vs. 70-70%) of the ECG-based tube current modulation in these individuals (correlation pitch - DLP: ρ = 0.08, p = 0.69; pitch - excess foci: ρ = -0.14, p = 0.49). Conclusion: γ-H2AX immunofluorescence microscopy is a valid and sensitive method for biodo-simetric measurement in cardiac CT. Foci representing DNA DSBs reflect the biological dose and consider the effects of different scan parameters on the radiation-induced biological damage.

  9. Investigation into the frequency of examinations and age distribution in nuclear medicine and the resulting collective dose in the GDR; Erhebungen zur Haeufigkeit und Altersverteilung sowie der kollektiven Dosis in der Nuklearmedizin in der DDR

    Energy Technology Data Exchange (ETDEWEB)

    Tautz, M. [Inst. fuer Medizinische Physik, Klinikum Berlin-Buch (Germany); Ertl, S. [Inst. fuer Medizinische Physik, Klinikum Berlin-Buch (Germany); Deckart, H.F. [Inst. fuer Medizinische Physik, Klinikum Berlin-Buch (Germany)

    1995-12-31

    In report nos. 26 and 60, the ICRP has outlined possible policies for the assessment of radiation exposures that provided a basis for the discussions in this contribution. For the period from 1978 until 1988 data were collected of patients undergoing any of the twelve nucleomedical in-vivo examinations that were most commonly performed in the GDR. The organ doses for the individual procedures were basically adopted from the relevant literature. The essential conclusions from the study can be summarized as follows: Despite the growing number of patients in this branch of medicine it was found that the mean equivalent dose (effective body dose), and hence the radiation risk, were systematically diminished by a factor of approx. three. This reduction is mainly attributable to the fact that radioiodine tests have been largely abondoned to the favour of Tc-99m compounds, which are now increasingly used. Nevertheless, the current understanding is that there still remains a remote possibility of resulting injuries. The radiation risk must therefore be carefully balanced agaisnt the overall benefits from any procedures using radioactive substances. The mean effective dose equivalent, which is expressed here on a per caput basis, is low in comparison with relevant values for other countries, which seems to be owing to the fact that physcians specializing in nuclear medicine in the GDR have been urging the use of standardized examination procedures over the past few decades. (orig./MG) [Deutsch] Die ICRP hat in ihren Reports Nr. 26 und 60 Konzepte zur Beurteilung der Strahlenexposition vorgeschlagen, auf deren Basis dieser Vortrag entstand. Fuer den Zeitraum von 1978-1988 wurden die Daten von Patienten erfasst, die sich den 12 haeufigsten nuklearmedizinischen in vivo Untersuchungsverfahren der DDR unterzogen. Die Organdosen fuer die einzelnen Verfahren wurden im wesentlichen der Literatur entnommen. Die wesentlichsten Ergebnisse der Studie koennen folgendermassen zusammengefasst werden: Trotz steigender Patientenzahlen ist eine systematische Reduzierung der durchschnittlichen somatisch effektiven Aequivalentdosis und damit des Strahlenrisikos um etwa den Faktor 3 festzustellen. Diese Verringerung ist vor allem auf den starken Rueckgang der Radiojod-Tests und die zunehmende Verwendung von Tc-99m-Verbindungen zurueckzufuehren. Trotzdem muss man nach heutiger Kenntnis mit einer gewissen, wenn auch sehr geringen Wahrscheinlichkeit rechnen, dass ein Schaden auftreten kann. Dem Strahlenrisiko ist stets der Gesamtnutzen nuklearmedizinischer Methoden entgegenzustellen. Die durchschnittliche effektive Aequivalentdosis, hier umgerechnet pro Kopf der Gesamtbevoelkerung, hat im Vergleich zu anderen Laendern einen kleinen Wert, was darauf zurueckgefuehrt werden kann, dass die Nuklearmediziner der DDR jahrzehntelange Bemuehungen um standardisierte Untersuchungsverfahren nachweisen konnten. (orig./MG)

  10. EPR response of sucrose and microcrystalline cellulose to measure high doses of gamma radiation; Respuesta EPR de sacarosa y celulosa micro cristalina para medir altas dosis de radiacion gamma

    Energy Technology Data Exchange (ETDEWEB)

    Torijano, E.; Cruz, L.; Gutierrez, G.; Azorin, J.; Aguirre, F. [Universidad Autonoma Metropolitana, Unidad Iztapalapa, Av. San Rafael Atlixco 186, Col. Vicentina, 09340 Mexico D. F. (Mexico); Cruz Z, E., E-mail: eftc@xanum.uam.mx [UNAM, Instituto de Ciencias Nucleares, Circuito Exterior, Ciudad Universitaria, 04510 Mexico D. F. (Mexico)

    2015-10-15

    Solid dosimeters of sucrose and microcrystalline cellulose (Avicel Ph-102) were prepared, following the same process, in order to compare their EPR response against that of the l-alanine dosimeters considered as reference. All lots of dosimeters were irradiated with gamma radiation in Gamma beam irradiator with 8 kGy/h of the Nuclear Sciences Institute of UNAM. Doses ranged from 1 to 10 kGy respectively. We found that both the response of sucrose as microcrystalline cellulose were linear; however, the response intensity was, on average, twenty times more for sucrose. Comparing this against the EPR response of l-alanine in the range of doses, it was found that the response to sucrose is a third part; and microcrystalline cellulose is a sixtieth, approximately. The results agree with those found in the literature for sucrose, leaving open the possibility of investigating other dosage ranges for cellulose. (Author)

  11. Control dose in chest radiography after the installation of the computed radiography; Control de dosis impartidas en radiografia de torax tras la instalacion de un sistema de radiografia computerizada

    Energy Technology Data Exchange (ETDEWEB)

    Minano Herrero, J. A.; Solar Cantos, M. M.; Roldan Arjona, J. M.; Martinez Cobos, R.

    2006-07-01

    The aim of this work is to verify patient does after the installation of the computed radiography. Entrance surface doses were obtained from a measurement of the output of the x-ray tube and exposure factor used at posteroanterior (PA) and lateral (LAT) chest in 50 adult patients before and after the installation. The obtained average values were 0.28{+-}0.10mGy in the PA view and 0.8{+-}0.5 mGy in the LAT view with the conventional screen-film system 0.27{+-}0.06 mGy in PA view and 0.69{+-}0.18 mGy in LAT view with the digital radiography system. The results do not exceed the diagnostic reference levels (DRLs) and are constant after the change of system. (Author)

  12. Comparison in the determination of absorbed dose by biological and physical methods to patients in treatment of cardiac intervention; Comparacion en la determinacion de dosis absorbida por metodos biologicos y fisicos a pacientes en tratamiento de intervencionismo cardiaco

    Energy Technology Data Exchange (ETDEWEB)

    Guerrero C, C.; Arceo M, C., E-mail: citlali.guerrero@inin.gob.mx [ININ, Departamento de Biologia, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2014-10-15

    The use of less invasive procedures, lower risk and quick recovery as cardiac intervention have proven to be an efficient alternative to reestablish the correct bloodstream of the patient. In this case the patient is subjected to values of absorbed dose above to which is subjected in a study with X-rays for medical diagnosis, and this can cause radiation injuries to the skin. The target organ, in this case can be exposed to doses of 2 Gy above. Different methods to estimate the dose were use, physical by Radiochromic film, as biological by dicentric analysis. Both methods provided additional information demonstrating thus the risk in the target organ and the patient. The most reliable biological indicator of exposure to ionizing radiation is the study of chromosomal aberrations, specifically dicentric in human lymphocytes. This test allowed establishing the exposure dose depending of the damage. (Author)

  13. Implications of the new dose limit crystalline in operational radiation protection in interventional medicine; Implicaciones del nuevo limite de dosis en cristalino en la proteccion radiologica operacional en intervencionismo

    Energy Technology Data Exchange (ETDEWEB)

    Roch Gonzalez, M.; Garcia Castanon, P.; Giner Sala, M.; Rodriguez Martin, G.; Espana Lopez, M. L.

    2013-07-01

    The objective of this study is to evaluate the implications of this new limit of equivalent dose in the lens can be assumed in the radiation protection of cardiologists, radiologists, nursing professionals, etc. that perform their work in units of intervention, both in terms of additional protective measures and the classification of them as workers exposed. (Author)

  14. Radiation doses to adult patients in interventional procedure: the first data for the Biobio region; Dosis de radiacion a pacientes adultos en procedimientos de intervencionismo: los primeiros datos para la region del Biobio

    Energy Technology Data Exchange (ETDEWEB)

    Ubeda, C.A.; Nocetti, D.A., E-mail: carlos.ubeda.uta@gmail.com [Universidade de Tarapaca (Chile). Centro de Estudos en Ciencias Radiologicas (CECRad). Dept. de Tecnologic Medica. Facultad de Ciencias de la Salud (FACSAL); Robles, I.L., E-mail: isabel.robles.p@gmail.com [Hospital Clinico Guilhermo Grant Benavente, Concepcion (Chile). Servico de Imagenologia

    2013-11-01

    The main objective of this study was to estimate the levels of radiation to the patient in interventional cardiology procedures and neurological (diagnostic and therapeutic) in the main public hospital in Chile, in the region of Biobio.

  15. Statistical Review of surface dose in the period 1995-2010, measured by different types of TLD dosimeters; Revision estadistica de las dosis superficiales, en el periodo 1995-2010, medidas mediante distintos tipos de dosimetros TLD

    Energy Technology Data Exchange (ETDEWEB)

    Pastor Antolin, S.; Munoz Blasco, J.; Llansana Arnalot, J.; Gultresa Colomer, J.

    2011-07-01

    We analyzed the evolution of the number of special controls over the period 1985 to 2010 and the evolution of the doses in the period 1995 to 2010. Comparing the standard dose extremities respect to whole body in cases where users use both types of control in the same installation.

  16. Evaluation of dose due to the liberation of the radioactive content present in systems of final disposal of radioactive residues; Evaluacion de la dosis debida a la liberacion del contenido radiactivo presente en sistemas de disposicion final de residuos radiactivos

    Energy Technology Data Exchange (ETDEWEB)

    Amado, V.; Lopez, F. [Autoridad Regulatoria Nuclear, Av. Del Libertador 8250, Ciudad Autonoma de Buenos Aires (C1429BNP) (Argentina)]. e-mail: vamado@cae.arn.gov.ar

    2006-07-01

    The disposal systems of radioactive residuals well-known as repositories near to the surface, are used to dispose residuals that can contain high concentrations of radionuclides of period of short semi disintegration, which they would decay at levels radiologically insignificant in some few decades or in some centuries: and acceptably low concentrations of radionuclides of period of long semi disintegration. The dose that would receive the critic group due to these systems it could be increased by cause of discreet events that affect the foreseen retard time, or by the gradual degradation of the barriers. To this last case it contributes the presence of water, because it implies leaching and dissolution that can give place to radionuclide concentrations in the underground water greater to the prospective ones. The dosimetric evaluation is important because it offers useful objective information to decide if a given repository is adjusted to the purposes of its design and it fulfills the regulatory requirements. In this work a simplified evaluation of the dose that would receive the critic group due to the liberation of contained radionuclides in a hypothetical system of final disposition of radioactive residuals is presented. For it, they are considered representative values of the usually contained activities in this type of systems and they are carried out some approaches of the source term. The study is developed in two stages. In the first one, by means of the Radionuclide pollutant scattering pattern in phreatic aquifers (DRAF) it is considered the scattering of the pollutants in the phreatic aquifer, until the discharge point in the course of the nearest surface water. This model, developed originally in the regulatory branch of the National Commission of Argentine Atomic Energy (CNEA); it solves the transport equation of solutes in porous means in three dimensions, by the finite differences method having in account the soil retention and the radioactive decay. In the second stage, the PC CREAM program (Consequences of Releases to the Environment Assessment Methodology) it allows to study the scattering in the surface water until the location of the critic group and to carry out the dosimetric evaluation. The objective of the work is to show the utility of these models to estimate, with regulatory purposes and by means of preservative criteria, the order of magnitude of the expected concentrations and the involved doses. (Author)

  17. Determination of the dose rapidity of a {sup 90} Sr beta radiation source using thermoluminescent dosemeters; Determinacion de la rapidez de dosis de una fuente de radiacion beta de {sup 90}Sr usando dosimetros termoluminiscentes

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez M, P.R.; Azorin N, J.; Rivera M, T. [Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    2000-07-01

    The thermoluminescent dosemeters developed in Mexico, have been used efficiently in environmental and personal dosimetry. When the dose rate of some source is not known can be estimated with the use of thermoluminescent dosemeters taking in account the geometrical array used in the irradiations for reproducibility of the results in posterior irradiations. In this work it was estimated the dose rate of a {sup 90} Sr-{sup 90} Y beta radiation source which is property of the Nuclear Sciences Institute, UNAM, therefore it was l ended to the Metropolitan Autonomous University- Iztapalapa Unit for the characterization of new Tl materials, taking account of the institutional collaboration agreements. (Author)

  18. Nuclear medicine at Camaguey, 1995-1999. Frequency of examinations and collective effective dose to the population; Medicina nuclear en Camaguey, 1995-1999. Frecuencia de examenes y dosis efectiva colectiva a la poblacion

    Energy Technology Data Exchange (ETDEWEB)

    Barreras, C. Aldo; Brigido, F. Osvaldo; Naranjo, L. Angela [Centro de Atencion a la Actividad Nuclear, Camaguey (Cuba)]. E-mail: sean@caonao.cmw.inf.cu; Lasserra, S. Oscar; Hernandez, G. Jose [Hospital Oncologico Maria Curie, Camaguey (Cuba)

    2001-07-01

    A study of the frequency of examinations for diagnosis in the territory of Camaguey-Ciego de Avila, Cuba, was made from the accumulated statistic in the period of 1995-1999 with the objective to obtain data to estimate the collective dose distributed to the population of this territory. It was determined that the annual frequency average of examinations was of 3,82 by each 1000 inhabitants. The obtained data allowed to evaluate the contribution of the different examinations from the collective dose, corresponding to the gamma radiographs of thyroid and pick up 43,73 and 43,36%, respectively, of the 54,43 Sv.man distributed to the population like annual. In this work the annual behavior of the collective dose for the studied period and its behavior in relation to the frequency of made examinations are analyzed. The smaller annual collective dose corresponded to 1996 with 39,05 Sv.man, while the greater value corresponded to 1999 with 66,67 Sv.man. The additional total damage for the studied period is considered: there would be 19,87 additional cases like result of 21073 nuclear medicine examinations, of which 13,6 correspond to mortal cancer. The obtained results are compared with the results reported for other countries.

  19. Estimation of population doses in Spain from diagnostic procedures in radiology and nuclear medicine.; Estimacion de las dosis poblacionales en Espana por procedimientos diagnosticos de radiologia y medicina nuclear

    Energy Technology Data Exchange (ETDEWEB)

    Ruiz-Cruces, R.; Ramirez, M. L.; Canete, S.; Ruiz, A.; Perez-Martinez, M.; Alonso-Farto, J. c.; Moreno, S.; Ferrer, N.; Pola, A.; Alvarez, C.; Fernandez-Vazquez, M. I.; Gil-Gahete, J. M.; Rodriguez, M.

    2013-10-01

    In recent years there has been a significant increase in the number of medical examinations performed using ionising radiations. For this reason the European Commission took the initiative of estimating the dose to the population as a result of these practices. In Spain the CSN is undertaking the Dopoes and Domnes projects in collaboration with other bodies. (Author)

  20. Population dose from nuclear medicine studies (DOMNES). Contribution of Project DOMNES to Dose Datemed2; Dosis poblacionales por estudios de medicina nuclear (Domnes). Contribucion del proyecto Domnes a Dose Datemed2

    Energy Technology Data Exchange (ETDEWEB)

    Ramirez, M. L.; Ruiz, A.; Ferrer, N.; Alonso Farto, J. C.; Alvarez, C.; Rodriguez, M.

    2013-07-01

    The DOMNES Project is created in 2001 to carry out a survey on nuclear medicine procedures used in the Spanish health centers, their frequency and the doses given to patients. In addition, it reports information to Dose Data Project Med 2, focusing on radiology exams. (Author)

  1. Dose calculations for a simplified Mammosite system with the Monte Carlo Penelope and MCNPX simulation codes; Calculos de dosis para un sistema Mammosite simplificado con los codigos de simulacion Monte Carlo PENELOPE y MCNPX

    Energy Technology Data Exchange (ETDEWEB)

    Rojas C, E.L.; Varon T, C.F.; Pedraza N, R. [ININ, 52750 La Marquesa, Estado de Mexico (Mexico)]. e-mail: elrc@nuclear.inin.mx

    2007-07-01

    The treatment of the breast cancer at early stages is of vital importance. For that, most of the investigations are dedicated to the early detection of the suffering and their treatment. As investigation consequence and clinical practice, in 2002 it was developed in U.S.A. an irradiation system of high dose rate known as Mammosite. In this work we carry out dose calculations for a simplified Mammosite system with the Monte Carlo Penelope simulation code and MCNPX, varying the concentration of the contrast material that it is used in the one. (Author)

  2. A model based on the Fermi-Dirac distribution to determine the dose profile of a photon beam; Un modelo basado en la distribucion de Fermi-Dirac para determinar el perfil de dosis de un haz de fotones

    Energy Technology Data Exchange (ETDEWEB)

    Guerrero, R.; Silva, P.; Gutt, F.; Diaz, J. [Instituto Venezolano de Investigaciones Cientificas (IVIC), Laboratorio Secundario de Calibracion Dosimetrica (LSCD), Apartado 21827, Caracas 1020 A (Venezuela)

    1998-12-31

    The objective of this work is to propose a new model based in the Fermi-Dirac distribution, in which it is considered that the photon beams possess a particles behavior when they interact with the matter. (Author)

  3. Proposed procedure and analysis of results to verify the indicator of the product dose-area in radiology equipment; Procedimiento propuesto y analisis de resultados para verificar el indicador del producto dosis-area en equipos de radiologia

    Energy Technology Data Exchange (ETDEWEB)

    Garcia Marcos, R.; Gallego Franco, P.; Sierra Diaz, F.; Gonzalez Ruiz, C.; Rodriguez Checa, M.; Brasa Estevez, M.; Gomez Calvar, R.

    2013-07-01

    The aim of this work is to establish a procedure to verify the value of the product dose-area showing certain teams of Radiology, with an alternative to the use of external transmission cameras. (Author)

  4. Staff dose of hospitalization in the treatment of patients in ophthalmic brachytherapy with 125 I; Dosis al personal de hospitalizacion en el tratamiento de pacientes de braquiterapia oftalmica con I-125

    Energy Technology Data Exchange (ETDEWEB)

    Terron Leon, J. A.; Gomez Palacios, M.; Moreno Reyes, J. C.; Perales Molina, A.

    2013-07-01

    The objective of this work, therefore, has been the evaluation of the dose levels which nursing staff can receive in care for ophthalmic brachytherapy patients treated with 125 I from measurements made on the same, evaluating, in an experimental way, job security following the PR rules laid down for these treatments. (Author)

  5. Calibration curve to establish the exposure dose at Co{sup 60} gamma radiation; Curva de calibracion para establecer dosis de exposicion a radiacion gamma de Co{sup 60}

    Energy Technology Data Exchange (ETDEWEB)

    Guerrero C, C.; Brena V, M. [Departamento de Biologia, Instituto Nacional de Investigaciones Nucleares, A.P. 18-1027, Mexico D.F. (Mexico)

    2000-07-01

    The biological dosimetry is an adequate method for the dose determination in cases of overexposure to ionizing radiation or doubt of the dose obtained by physical methods. It is based in the aberrations analysis produced in the chromosomes. The behavior of leisure in chromosomes is of dose-response type and it has been generated curves in distinct laboratories. Next is presented the curve for gamma radiation produced in the National Institute of Nuclear Research (ININ) laboratory. (Author)

  6. Evaluation of the influence of parameters that determine the mean glandular dose in mammography using different detectors; Evaluacion de la influencia de los parametros que determinan la dosis glandular media en Mamografia utilizando diferentes detectores

    Energy Technology Data Exchange (ETDEWEB)

    Costa, K.; Nogueira, M. S., E-mail: katicostabh@gmail.com [Centro de Desenvolvimento da Tecnologia Nuclear, Pos-graduacao em Ciencias e Tecnologia das Radiacoes, Minerais e Materiais / CNEN, Av. Pte. Antonio Carlos 6627, 31270-901 Belo Horizonte, Minas Gerais (Brazil)

    2015-10-15

    Full text: Mammography is a test used for early detection of breast cancer. The mean glandular dose (MGD) is dosimetric greatness accepted as indicative of carcinogenic risk induced by ionizing radiation in the breasts of women undergoing mammography exams. MGD value is estimated from the incident air kerma (k i), associated with conversion factors which depend on the half-value layer (HVL), the breast composition and thickness compressed breast. This study aims to evaluate the influence of the parameters used to determine the MGD using different measurement detectors. Measurements were performed on a Siemens Mammomat Model 300 Nova mammography equipment; this has the combinations Anode/Filter of Mo/Mo, Mo/Rh and W/Rh. Detectors used were the ionization chamber Model 10X6-6M manufactured by Radcal Co., two solid-state detectors, one Model AGMS-M manufactured by Radcal Co. and other Model Xi Mammo manufactured by UNFORS. The detectors measures were compared and the MGD value was estimated; differences between measurements and the reference values were higher in HVL and k i parameters. The results are displayed according to other published works. (Author)

  7. Verification of the dose in the inspection modules of Co-60 from Mexicali, B.C.N. through thermoluminescent dosimetry; Verificacion de la dosis en los modulos de inspeccion de Co-60 de Mexicali, B.C. mediante dosimetria termoluminiscente

    Energy Technology Data Exchange (ETDEWEB)

    Cruz C, D.; Azorin, J.; Rivera, T. [UAM-I, 09340 Mexico D.F. (Mexico)

    2005-07-01

    On the February and April 2005 months, there entered in operation two inspection modules, in the mexican border city of Mexicali. B.C.N., those which they work based on gamma rays, emitted by sources of {sup 60} Co; this fact generate a concern, on the part of the population of this city. Soon after these events, a group of personages of the local politics, they began a campaign, in favor of closing these modules, based on the supposition, of that the emitted radiation by these sources, represents a danger for health of people that uses the international crossing located to a side of the porter lodge 1, as well as of the population in general. As service to the community border of Mexico specifically to the population of Mexicali, B.C.N. city, inhabitants of this city, municipal, state and federal authorities and, the outstanding preoccupation of the Republic Senate (Commission of Border Affairs), the National Commission of Nuclear Security and Safeguards (CNSNS) they requested the support of the Metropolitan Autonomous University (UAM) and of the National Polytechnic Institute (IPN) to verify the radiation levels in the facilities of the sources of {sup 60} Co of the porter lodges of Mexicali-Calexico proceeding to the monitoring of this facilities in the period of 14-17 June 2005, 17 using thermoluminescent dosemeters elaborated in Mexico. (Au0010th.

  8. Verification of dose distributions of intensity-modulated radiotherapy beams using a portal imaging device; Caracterizacion de un sistema de imagen portal basado en silicio amorfo para la medida de distribuciones de dosis absorbida

    Energy Technology Data Exchange (ETDEWEB)

    Perez Moreno, J. M.; Fernandez Leton, J. P.; Zucca Aparicio, D.; Garcia Ruiz-Zorrila, J.; Minambres Moro, A.

    2011-07-01

    We have developed a method for using a portal imaging device based on amorphous silicon (EPID) for the dosimetric verification of intensity modulated radiotherapy (IMRT) treatments using 6 MV beams. The images obtained using the imaging system are de convolved with a kernel for radiation and scattering of light generated in the EPID. This kernel has an analytical form and has been experimentally determined. The fluence thus obtained is convolved with a dose deposition kernel, also modeled analytically in a empirical way. The result is an absorbed dose distribution in water at 5 cm depth. The difference between the measured dose using portal imaging device and ionization chamber is -0.3 {+-} 0.9 % in open fields, with a maximum deviation of 1.5% in a 20 cm X 20 cm field with 60 degree centigrade virtual wedge. The degree of agreement between dose distributions measured with the EPID and ionization chamber array is satisfactory, exceeding all cases evaluated 95% of points with {gamma} < 1 using 3%, 3 mm criteria for gamma analysis. (Author) 25 refs.

  9. Comparison of radiation doses obtained for radiation monitoring of controlled areas with radiation doses obtained for personnel dosimetry in radiodiagnosis centers; Comparacion de dosis obtenidas por monitoreo en areas controladas con las obtenidas por dosimetria personal en centros de radiodiagnostico

    Energy Technology Data Exchange (ETDEWEB)

    Lescano, Roberto; Caspani, Carlos [Ministerio de Salud y Medio Ambiente, Santa Fe (Argentina). Direccion General de Auditoria Medica. Radiofisica Sanitaria]|[Universidad Nacional del Litoral, Santa Fe (Argentina). Faculdad de Bioquimica y Ciencias Biologicas. Escuela Superior de Sanidad

    2001-07-01

    In this paper we propose to search an indicator that shows, at an objective way, the quality of the radioprotection actions. The method is about to determine doses, measured in the work area, connecting them with the workload, and finally get the dose for the center. Them we make a comparison with the personal film dosimetry data. We discuss the final results, evaluating the radioprotection conditions in daily work. (author)

  10. Calculation of absorbed doses in sphere volumes around the Mammosite using the Monte Carlo simulation code MCNPX; Calculo de dosis absorbida en volumenes esfericos alrededor del Mammosite utilizando el codigo de simulacion Monte Carlo MCNPX

    Energy Technology Data Exchange (ETDEWEB)

    Rojas C, E. L. [ININ, Carretera Mexico-Toluca s/n, Ocoyoacac 52750, Estado de Mexico (Mexico)

    2008-07-01

    The objective of this study is to investigate the changes observed in the absorbed doses in mammary gland tissue when irradiated with a equipment of high dose rate known as Mammosite and introducing material resources contrary to the tissue that constitutes the mammary gland. The modeling study is performed with the code MCNPX, 2005 version, the equipment and the mammary gland and calculating the absorbed doses in tissue when introduced small volumes of air or calcium in the system. (Author)

  11. Dose absorbed in adults and children thyroid due to the I{sup 123} using the dosimetry MIRD and Marinelli; Dosis absorbida en tiroides de adultos y ninos debido al I{sup 123} utilizando las dosimetrias MIRD y Marinelli

    Energy Technology Data Exchange (ETDEWEB)

    Vasquez, M.; Castillo, C.; Cabrera, C.; Sarachaga, R.; Castaneda, J. [Universidad Nacional de Trujillo, Av. Juan Pablo II s/n, Ciudad Universitaria, Trujillo (Peru); Diaz, E., E-mail: marvva@hotmail.com [Universidade Federal do Rio Grande do Sul, Av. Paulo Gamma 110, Bairro Farropilhas, Porto Alegre, RS 90040-060 (Brazil)

    2014-08-15

    Using the dosimetry MIRD, and representation Cristy-Eckerman in the thyroid gland and organs of their bio-kinetics when I{sup 123} (Iodine) is used, the study demonstrates that the absorbed dose by the gland of an adult, children, and newly born, is their auto-dose, independent of the compartments number of their bio-kinetics. The dosimetric contributions of the organs of their bio-kinetics are insignificant. Their results are not significantly different to those obtained by the formalism MARINELLI (auto-dose) when it uses a sphere like glandular representation. In consequence, the kinetic model corresponding to the glandular representation decreases to a compartment, where the gland can also be represented like a sphere. (Author)

  12. Perfil metabòlic de resveratrol, flavonols i isoflavones en teixits biològics administrats a dosis dietètiques. Noves metodologies analítiques.

    OpenAIRE

    Urpí Sardà, Mireia

    2008-01-01

    Estudis epidemiològics han posat en evidència la importància del consum de dietes riques en aliments d'origen vegetal en la prevenció de malalties cardiovasculars, càncer i malalties neurodegeneratives. Aquests efectes beneficiosos s'han relacionat amb l'existència de compostos bioactius en aliments vegetals com poden ser els polifenols. Però per a poder extrapolar aquests resultats i valorar els efectes fisiològics in vivo és necessari estudiar la seva absorció, metabolisme i capacitat d'exc...

  13. Spectra and neutron dose of an 18 MV Linac using two geometric models of the head; Espectros y dosis por neutrones de un Linac de 18 MV usando dos modelos geometricos del cabezal

    Energy Technology Data Exchange (ETDEWEB)

    Barrera, M. T.; Pino, F.; Barros, H.; Sajo-Bohus, L. [Universidad Simon Bolivar, Laboratorio de Fisica Nuclear, Sartenejas, Baruta 1080-A, Caracas (Venezuela, Bolivarian Republic of); Davila, J. [Fisica Medica C. A., Av. Francisco de Miranda s/n, Los Palos Grandes, 1060 Miranda (Venezuela, Bolivarian Republic of); Salcedo, E. [Centro Medico Docente La Trinidad, Av. de El Haltillo, Caracas (Venezuela, Bolivarian Republic of); Vega C, H. R. [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas, Zac. (Mexico); Benites R, J. L., E-mail: mariate9590@gmail.com [Centro de Cancerologia de Nayarit, Servicio de Seguridad Radiologica, Calz. de la Cruz 118 Sur, 63000 Tepic, Nayarit (Mexico)

    2015-10-15

    Full text: Using the Monte Carlo method, by MCNP5 code, simulations were performed with different source terms and 2 geometric models of the head to obtain spectra in energy, flow and doses of photo-neutrons at different positions on the stretcher and in the radiotherapy room. The simplest model was a spherical shell of tungsten; the second was the complete model of a heterogeneous head of an accelerator Varian ix. In both models Tosi function was used as a source term. In addition, for the second model Sheikh-Bagheri distribution was used for photons and photo-neutrons were generated. Also in both models the radiotherapy room of Gurve group of the Teaching Medical Center La Trinidad was included, which is equipped with an accelerator Varian Clinic 2100. In this Center passive detectors PADC (Cr-39) were irradiated with neutron converters, with 18 MeV photons radiation. The measured neutron flow was compared with that obtained with Monte Carlo calculations. The Monte Carlo flows are similar to those measured at the isocenter. The simplest model underestimates the neutron flow compared with the calculated flows with the heterogeneous model of the head. (Author)

  14. Neutron spectra calculation and doses in a subcritical nuclear reactor based on thorium; Calculo de espectros de neutrones y dosis en un reactor nuclear subcritico a base de Torio

    Energy Technology Data Exchange (ETDEWEB)

    Medina C, D.; Hernandez A, P. L.; Hernandez D, V. M.; Vega C, H. R. [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas, Zac. (Mexico); Sajo B, L., E-mail: dmedina_c@hotmail.com [Universidad Simon Bolivar, Laboratorio de Fisica Nuclear, Apdo. Postal 89000, Caracas 1080A (Venezuela, Bolivarian Republic of)

    2015-10-15

    This paper describes a heterogeneous subcritical nuclear reactor with molten salts based on thorium, with graphite moderator and a source of {sup 252}Cf, whose dose levels in the periphery allows its use in teaching and research activities. The design was done by the Monte Carlo method with the code MCNP5 where the geometry, dimensions and fuel was varied in order to obtain the best design. The result is a cubic reactor of 110 cm side with graphite moderator and reflector. In the central part they have 9 ducts that were placed in the direction of axis Y. The central duct contains the source of {sup 252}Cf, of 8 other ducts, are two irradiation ducts and the other six contain a molten salt ({sup 7}LiF - BeF{sub 2} - ThF{sub 4} - UF{sub 4}) as fuel. For design the k{sub eff}, neutron spectra and ambient dose equivalent was calculated. In the first instance the above calculation for a virgin fuel was called case 1, then a percentage of {sup 233}U was used and the percentage of Th was decreased and was called case 2. This with the purpose to compare two different fuels working inside the reactor. In the case 1 a value was obtained for the k{sub eff} of 0.13 and case 2 of 0.28, maintaining the subcriticality in both cases. In the dose levels the higher value is in case 2 in the axis Y with a value of 3.31 e-3 ±1.6% p Sv/Q this value is reported in for one. With this we can calculate the exposure time of personnel working in the reactor. (Author)

  15. Determination of the dose in eyes lens by TLD, in PET/CT by technicians in PET/CT service; Determinacion de la dosis en cristalino por medio de TLD, en personal tecnico de servicio PET/CT

    Energy Technology Data Exchange (ETDEWEB)

    Marino, Emiliano A., E-mail: eam.marino@gmail.com [Universidad Nacional de Cuyo (UNC), Rio Negro (Argentina). Instituto Balseiro; Arenas, German M. [Fundacion Escuela de Medicina Nuclear (FUESMEN), Mendoza (Argentina)

    2013-11-01

    This work was supported, on the one hand, in a part of the project ORAMED which consisted of a design of a TLD dosimeter for measurements of Hp (3) in areas close to the lens, for interventional radiology physicians. On the other hand, Berhens work proposes using calibrated TLDs Hp (0.07) and Hp (10) to estimate Hp (3) crystal. This resulted in dosimeters calibrated using Hp (10) slab, and mount them on glasses, to estimate the dose to the lens of the technical staff of the Service PET / CT. The value obtained 29mSv/year of Lens Dose Equivalent exceeds the recommended limit. We also demonstrate that, under the current working conditions, the values of Hp (3) reported from whole body dosimeter does not represent faithfully the lens dose.

  16. Final results of the DOPOES project. Estimation of doses to populations in Spain as a result Medical Radiodiagnostic; Estimacion de las dosis a las poblaciones en Espana como consecuencia del radiodiagnostico medico

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2015-07-01

    In 2011, a specific agreement was signed between the Nuclear Safety Council and the University Malaga for carrying out a survey of used radiology procedures in the Spanish sanitary centers, its frequency and doses received by patients. (Author)

  17. Measurement of the relationship of {sup 24} Na activity and the received neutron dose; Medicion de la relacion de la actividad de {sup 24}Na y la dosis de neutrones recibida

    Energy Technology Data Exchange (ETDEWEB)

    Gossio, S.; Carrelli, J.; Villella, A.; Soppe, E., E-mail: sgossio@arn.gob.ar [Autoridad Regulatoria Nuclear (ARN), Buenos Aires (Argentina)

    2013-07-01

    In cases of criticality accidents it is required a fast dosimetric system that allows to evaluate the doses of the personnel involved. The reaction (n,y) with sodium presented in the body ({sup 23}Na), generates {sup 24}Na, that emits two gamma of 1369KeV and 2754 KeV that can be measured using a whole body counter. The experienced were carried out with the irradiation of {sup 252} Cf of a phantom with a solution of NaCl in water. After the irradiation it was measured the {sup 24}Na activity in the whole body counter, which has a HPGe detector previously calibrated in energy and efficiency. Considering the correction by decay, the quantity of {sup 23}Na presented in the body of an adult and elimination curve of {sup 24}Na, it was established a coefficient of neutronic doses by unity of activity of {sup 24}Na measured in the whole body counter. This method is useful for the retrospective estimation of the doses, as well as to carry out a radiological sorting in case of criticality.

  18. Gamma knife radio-surgery in meningiomas: decisive variables in the dose prescription during 14 years; Radiocirugia gamma knife en meningiomas: variables determinantes en la prescripcion de dosis durante 14 anos

    Energy Technology Data Exchange (ETDEWEB)

    Dominguez O, X.; Diaz A, P.; Toledo B, V.; Zazueta L, F., E-mail: pdiaz@hospitalsanjavier.co [Hospital San Javier, Pablo Casals No. 640, Col. Prados Providencia, 44670 Guadalajara, Jalisco (Mexico)

    2010-09-15

    A comparative study is presented among the variables of dose prescription in twelve cases of treated meningiomas from 1997 to 2009 in the Gamma Knife Unit of the Hospital San Javier. An evolution is observed in the definition of the treatment volumes, collimators election and matrix of dose calculation, this evolution has been due so much to the technological advance associated to the image acquisition systems: Computerized axial tomography, Images by magnetic resonance and Angiography by digital subtraction, as well as to the indexes adoption that are used to qualify among different treatment plans. The differences among the analyzed periods demonstrate a favorable learning curve that have influenced contributing to a treatment with a minor irradiated volume due to the application of theoretical models used in this installation, attenuating the risk of peripheral unexpected complications to the treated volume. (Author)

  19. Efecto de la escarificación y la dosis del ácido giberélico (ag3) en la germinación de semilla de curuba (passiflora mollisima)

    OpenAIRE

    Cardozo Gutiérrez, Rito Hernán

    2011-01-01

    Los ensayos de la germinación de semilla de curuba (Passiflora mollisima (HBK) Bailey en condiciones de laboratorio, muestran que la testa retarda la absorción del agua y es el principal factor de control de la germinación. El ácido giberélico aplicado incrementa la germinación y refuerza considerablemente los efectos de la escarificación.

  20. Penurunan Kadar Gula Darah pada Monyet Ekor Panjang Obes dengan Pemberian Nikotin Dosis Rendah (DECRESE IN BLOOD SUGAR LEVEL IN LONG TAILED OBESE MACAQUES GIVING WITH LOW DOSE NICOTINE

    Directory of Open Access Journals (Sweden)

    Chusnul Choliq

    2013-09-01

    Full Text Available The aim of the study was to evaluate the role of low dose nicotine on the profile of blood glucose and  â-cell of pancreatic islets.  Fourteen adult (aged 6 – 8 years male cynomolgus monkeys grouped based ontheir Body Mass Index (BMI into preobese (BMI=23.65 – 25.00 and obese (BMI e” 26.00 were used inthis study. Subsequently animals were grouped into four:  (i preobese monkeys with nicotine (pOb+, (iiobese monkeys with nicotine (Ob+, (iii preobese monkeys without nicotine (pOb-, and (iv obese monkeyswithout nicotine (Ob-. Animals in the nicotine groups were fed with high fat diet mixed with nicotine dose0.5–0.75mg/kg body weight/day for three months and the others were fed Monkey Chow® only as thecontrol group. Blood samples were collected every month for glucose analysis and necropsy was performedat the end of study. Pancreas tissues were processed histologically and stained using  immunohistochemicalmethod. The results showed that the blood glucose either preobese (28.37% or  obese (33.72% animals inthe nicotine groups significantly decrease (p<0.05 during the study period in comparison to the controlgroup.  Based on brown color intensity of granules cytoplasm of insulin producing cells or immunoreactiveâ-cells, it is shown that the cells of animals in the non nicotine group were more reactive than those in thenicotine groups. In conclusion, there was positive effect of low dose nicotine in maintaining the bloodglucose level in normal range by stimulation of islet cells proliferation to maintain the production ofinsulin in the pancreatic islet.

  1. Comparison of the dose deposited between the OBI system and the Varian TrueBeam Imaging system; Comparacion de la dosis depositada entre el sistem OBI y el truebeam Imaging system de Varian

    Energy Technology Data Exchange (ETDEWEB)

    Pino, F.; Navarro, D.; Sancho, I.; Lizuain, M. C.

    2011-07-01

    The use of imaging systems for positioning kilovoltage radiotherapy treatments has experienced a peak in recent years. Techniques such as IMRT, these systems are applied to a large number of sessions to ensure accurate positioning. This makes it increased the interest to know the dose deposited in the patient. Companies involved in developing new designs focus their efforts on reducing the dose due to these positioning systems. The aim of this study is to compare the dose delivered by the OBI image guidance system with the new system image TrueBeam, both of Varian, both planar imaging as CT (CBCT).

  2. Characterization of a team intraoperative Radiation therapy and measurement of dose in skin with film radiochromic; Caracterizacion de un equipo de radioterapia intraoperatoria y medida de la dosis en piel con pelicula radiocromica

    Energy Technology Data Exchange (ETDEWEB)

    Onses Segarra, A.; Sancho Kolster, I.; Eraso Urien, A.; Pla Farnos, M. J.; Picon Olmos, C.

    2015-07-01

    This paper presents the results of the initial reference state of intraoperative radiotherapy equipment lntraBeam, for performing breast treatments are analyzed. To the initial reference team was established for the following dosimetric and geometric beam parameters: percentage depth dose, beam quality, isotropy, linearity and mechanical and geometric integrity for both the source RX as for different spherical applicators of the team. Based on these checks, a program of periodic quality control was established. One of the exclusion criteria for this treatment is that the tumor is less than l cm of the skin, yaque give doses received in this organ can be high. For this reason it is important to know exactly the absorbed dose in skin during these treatments. In this regard we have implemented a system for measuring the skin dose during treatment with Radiochromic film, placing 4 film segments in fixed positions of the skin around the surgical incision. It .ha obtained calibration curve of sterilized films and compared the results with a calibration beam megavoltage. The results of the skin dose measurements are compared with theoretical estimates given by the planning system equipment. The results indicate the need to measure individually the skin dose for these treatments. (Author)

  3. Aumento de dosis génica de los genes DPL1, SSD1 y SRP101 en Saccharomyces cerevisiae y fenotipo de tolerancia a acidificación intracelular

    OpenAIRE

    BERNABEU LORENZO, MANUEL

    2015-01-01

    [ES] El pH alto intracelular es una señal promotora del crecimiento y proliferación de las células pero sus mecanismos no son bien conocidos. En un trabajo previo se había identificado una región genómica de levadura que al ser transformada en plásmido de copia simple aumenta el crecimiento de la levadura en condiciones de acidificación intracelular. Esta región contiene tres genes, DPL1, SSD1 y SRP101 y en este trabajo hemos identificado el gen SSD1 como el responsable del fen...

  4. Estimate of the annual effective dose for natural radionuclides of anthropogenic origin in the Bay of Cadiz; Estimacion de la dosis efectiva anual correspondiente a radionucleidos naturales y de origen antropogenico en la Bahia de Cadiz

    Energy Technology Data Exchange (ETDEWEB)

    Rodrigo, J. F.; Martinez-Ramos, C.; Barbero, L.; Casas-Ruiz, M.

    2011-07-01

    Knowledge of radioactivity levels in soils has a double interest: on the one hand, allows you to set the reference values ??(base Linne) from a region or geographic area, and secondly, to evaluate the external radiation dose received by the population and biota, through appropriate dosimetric model. The natural radioactivity, especially the radionuclides in the natural series. The aim of this study is to determine the levels of gamma emitting radionuclides in marine sediments of the Bay of Cadiz, and dose rates from external radiation received in the areas studied. (Author)

  5. Calibration of a {sup 19} {sup 2}Ir source for high dose brachytherapy using various techniques; Calibracion de una fuente de {sup 192} Ir para braquiterapia de alta tasa de dosis mediante diversas tecnicas

    Energy Technology Data Exchange (ETDEWEB)

    Montilla Prieto, Tedicel C., E-mail: tcdicel@gmaiLcam [Instituto de Oncologia Dr. Miguel Perez Carreno, Barbula (Venezuela, Bolivarian Republic of). Departamento de Fisica y Dosimetria; Padron Rivero, Alvaro D., E-mail: alvarodpadronr@yahoo.com.ve [Universidad de Carabobo, Barbula (Venezuela, Bolivarian Republic of). Facultad de Ciencias de la Salud. Departamento de Ciencias Fisiologicas

    2013-10-01

    In this research we studied three experimental procedures for calibration of a source of {sup 192}Ir to high dose rate for clinical brachytherapy use, and thus were compared and analysis of the advantages and disadvantages of each. For this study we quantified the value of the current kerma rate reference in air by three procedures: source calibration using a well chamber, with an cylindrical ionization chamber in air, and a cylindrical ionization chamber on a phantom, and this magnitude was compared with the value provided by the manufacturer of the source and thereby obtaining the deviation corresponding . Thus, it was found that the deviation corresponding to the source calibration making use of a well chamber, remained within tolerance, while the cylindrical ionization chamber in air and on phantom exceeded the standards established in some documents. However, although both the measurement in air and in the phantom are the procedures for the final calibration source, these can be used to verify that the delivered dose are in tolerance.

  6. Temporal evolution of the environmental dose remaining in a clinical irradiation bunker after the cessation of irradiation; Evolucion temporal de la Dosis ambiental remanente en un bunker de irradiacion clinica tras el cese de la irradiacion

    Energy Technology Data Exchange (ETDEWEB)

    Ruiz Egea, E.; Sanchez Carrascal, M.; Torres Pozas, S.; Monja Ray, P. de la; Perez Molina, J. L.; Madan Rodriguez, C.; Luque Japon, L.; Morera Molina, A.; Hernandez Perez, A.; Barquero Bravo, Y.; Morengo Pedagna, I.; Oliva Gordillo, M. C.; Martin Olivar, R.

    2011-07-01

    In this paper we try to quantify the dose emitted by different radioactive processes that occur in the head of a clinical linear accelerator and the patient is irradiated, or walls of the bunker, converted into tertiary sources of radiation trying to establish the origin of the came in different parts of the bunker.

  7. Method for evaluation of doses from ingestion of polonium, bismuth and lead as natural radioactive material(NORM); Metodo de evaluacion de dosis por ingestion de polonio, bismuto y plomo como materiales radiactivos naturales

    Energy Technology Data Exchange (ETDEWEB)

    Pena, Vanessa; Puerta, Anselmo; Morales, Javier, E-mail: vpenam@ullal.edu.co, E-mail: japuerta@unal.edu.co, E-mail: jmorales@unal.cdu.co [Universidad Nacional de Colombia, Medellin (Colombia). Grupo de Fisica Radiologica

    2013-07-01

    In this work was carried out an evaluation of dose from ingestion of radioactive daughters of radon (lead, bismuth and polonium), taking into account ages from three months up to adult men, using the new model of the human alimentary tract HATM and methodology of calculating doses proposed by the ICRP publication 103, which allows the estimation of dose based on the concentration of the radionuclide present in the diet or in the water of consumption.

  8. Measurement of dose to skin using TLD of several radiodiagnostic studies in San Jose, Costa Rica; Medicion de dosis a piel utilizando TLD de varios estudios radiodiagnosticos en San Jose, Costa Rica

    Energy Technology Data Exchange (ETDEWEB)

    Mora, P. [Laboratorio de Fisica Nuclear Aplicada, Escuela de Fisica, Universidad de Costa Rica, San Jose (Costa Rica)

    1998-12-31

    It is quantified the radiation doses on skin for several radiodiagnostic studies in patients of the Calderon Guardia Hospital in San Jose, Costa Rica at the period October 1997-September 1998 using thermoluminescent dosemeters TLD 100. The crystals receive the decoction standard procedures and they are arranged at the middle of the irradiation field. For a total of 973 radiodiagnostic studies it was found that the dose on skin in mGy are: 2.09 for thorax AP/AP, 5.33 for thorax LAT, 5.35 for skull AP/PA, 2.98 for skull LAT, 10.74 for abdomen, hips and pelvis, 6.20 for spines AP, 9.35 for spines LAT, 11.48 for lumbar columns AP, 29.99 for lumbar columns LAT and 6.87 for intravenous skin diagrams (first plate ap). It is produced thus the first reference bank for the national hospitals, which is compared with the orientation levels of doses for IAEA. Recommendations to diminish the collective doses through quality control programs are discussed, taking as goal to have got radiographs of excellent diagnostic quality, but with the less possible doses. (Author)

  9. Verification of the calculation program for brachytherapy planning system of high dose rate (PLATO); Programa de verificacion del calculo para un sistema de planificacion de braquiterapia de alta tasa de dosis (PLATO)

    Energy Technology Data Exchange (ETDEWEB)

    Almansa, J.; Alaman, C.; Perez-Alija, J.; Herrero, C.; Real, R. del; Ososrio, J. L.

    2011-07-01

    In our treatments are performed brachytherapy high dose rate since 2007. The procedures performed include gynecological intracavitary treatment and interstitial. The treatments are performed with a source of Ir-192 activity between 5 and 10 Ci such that small variations in treatment times can cause damage to the patient. In addition the Royal Decree 1566/1998 on Quality Criteria in radiotherapy establishes the need to verify the monitor units or treatment time in radiotherapy and brachytherapy. All this justifies the existence of a redundant system for brachytherapy dose calculation that can reveal any abnormality is present.

  10. Comparative analysis of 2D and 3D dosimetry with brachytherapy high dose rate cervix carcinoma un operated; Analisis comparativo de dosimetria 2D y 3D con braquiterapia de alta tasa de dosis

    Energy Technology Data Exchange (ETDEWEB)

    Garcia Castejon, M. A.; Penedo Cobos, J. M.; Rincon Perez, M.; Gomez Alonso, S.; Luna Tirado, J.; Perez Casas, A. M.

    2011-07-01

    It has recently been installed in our department based on an SPB CT images, and found that the dose at points H is less than that obtained by calculations based on radiographs. This study aims to analyze this discrepancy in the transition from 2D to 3D calculation in patients with carcinoma of the cervix not operated.

  11. Development of practical digital radiographic image viewing and commitment dose/image quality; Desarrollo de practicas de visualizacion de imagenes radiograficas digitales y su compromiso dosis/calidad de imagen

    Energy Technology Data Exchange (ETDEWEB)

    Chinillach Ferrando, N.; Salvador, R.; Diez, S.; Reinado, D.; Cortina, T.; Lopez, F. J.; Jover, A.; Cebrian, R.; Gonzalez, R.; Dalmases, F.; Romero, C.; Rosello, J.

    2011-07-01

    Today it is essential to use X-ray diagnosis in health, so it is essential that professionals have a strong background in all aspects of radiological images dependent. It is also necessary to understand the dependence between dose and image quality and thus introduce the concept of optimization in the performance of radiologic studies, from a simple test to a complex, establishing a dependency between patient dose and the aim of the study to be performed.

  12. Dose in sensitive organs during the prostate treatment with a {sup 60}Co unit; Dosis en organos sensibles durante el tratamiento de prostata con una unidad de {sup 60}Co

    Energy Technology Data Exchange (ETDEWEB)

    Vega C, H. R. [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Apdo. Postal 336, 98000 Zacatecas (Mexico); Navarro B, J. A. [Universidad Autonoma de Zacatecas, Unidad Academica de Fisica, Carretera a la Bufa s/n, Zacatecas (Mexico); Perez A, M. L.; Perez L, L. H., E-mail: fermineutron@yahoo.com [Instituto Zacatecano del Tumor, A. C., Lago de la Encantada No. 294, Fracc. Lomas del Lago, Zacatecas (Mexico)

    2012-10-15

    The absorbed dose by the bladder, the rectum and the gland thyroid was measured during a treatment applied for prostate cancer by means of a Cobalt 60 unit. The dose was measured using thermoluminescent dosimeters of the type TLD 100, with the values of the absorbed the values of the effective dose were calculated and was determined the probability of the development of a secondary cancer. Because these measurements cannot be made -in vivo- a phantom or mannequin was built with water that represents the hip and part of the torso of the human body and to represent the neck was used polyethylene. The study was carried out in the Instituto Zacatecano del Tumor that has a -cobalt bomb- which is used to treat oncology patients, during the phantom irradiation a dose of 200 c Gy was applied of this dose the bladder received 96.7%, the rectum 100.8% and the gland thyroid 0.3%. The dose received by the rectum and the bladder is due to the therapeutic beam while the dose received by the thyroid is due to the dispersed radiation by the phantom. The probability that in these organs a new neoplasm is developed is of 0.033% for the bladder, 0.157% for the rectum and 7.8 x 10{sup -5}% for the thyroid case. (Author)

  13. Estimation of absorbed dose with CBCT in studies of prostate measured with TLD's pen and camera; Estimacion de dosis absorbida con CBCT en estuidos de prostata medida con camara lapiz y TLDs

    Energy Technology Data Exchange (ETDEWEB)

    Alonso Iracheta, L.; Capuz Suarez, B.; Cordoba Gomez, D.; Gomez Martin, C.; Miravilla Limorte, M.; Bejar Navarro, M. J.; Colmenares fernandez, R.; Moris Pablos, R.; Rot Sanjuan, M. J.

    2011-07-01

    The Cone Beam CT (CBCT) is an imaging system composed of an X-ray tube facing a flat panel built into the gas detection. Allows for Image Guided Radiation Therapy 3D (3D IGRT) by volumetric reconstructions of the patient in the treatment unit and overlay them with the reference CT to verify and / or correct the position of the tumor and / or organs at risk in the area treatment.

  14. Class solution to decrease rectal dose in prostate radiotherapy treatments 3D-CRT; Solucion de clase para disminuir dosis en recto en tratamientos de prostata con radioterapia 3D-CRT

    Energy Technology Data Exchange (ETDEWEB)

    Andres Rodriguez, C.; Tortosa Oliver, R.; Alonso Hernandez, D.; Mari Palacios, A.; Castillo Belmonte, A. del

    2011-07-01

    This paper contains a method developed in our center with conventional 3D radiotherapy techniques to increase the dose conformation around the target volume in prostate cancer treatments significantly reduced the doses to the rectum. To evaluate the goodness of the method, the results are compared with two classical techniques of treatment.

  15. Didactic revision of the operative magnitudes system ICRU for the evaluation of the equivalent dose in radiation external fields; Revision didactica del sistema de magnitudes operativas ICRU para la evaluacion de la dosis equivalente en campos externos de radiacion

    Energy Technology Data Exchange (ETDEWEB)

    Alvarez R, J. T., E-mail: trinidad.alvarez@inin.gob.mx [ININ, Departamento de Metrologia de Radiaciones Ionizantes, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2014-10-15

    In this work is presented in a didactic way the operative magnitudes system ICRU, showing as these magnitudes carry out an appropriate estimate of the effective equivalent doses H{sub E} and the effective dose. The objective is to present the basic concepts of the dosimetry for radiation external fields with purposes of radiological protection, because the assimilation lack and technological development of this dosimetric magnitudes system has persisted for near 50 years, in terms of practice of the radiological protection in Mexico. Also, this system is an essential part of safety basic standards of the IAEA and ICRP recommendations 26, 60, 74 and 103, as well as of the ICRU 25, 39, 43, 51 and 57. (Author)

  16. Monte Carlo design of a system for the detection of explosive materials and analysis of the dose; Diseno Monte Carlo de un sistema para la deteccion de materiales explosivos y analisis de la dosis

    Energy Technology Data Exchange (ETDEWEB)

    Hernandez A, P. L.; Medina C, D.; Rodriguez I, J. L.; Salas L, M. A.; Vega C, H. R., E-mail: pabloyae_2@hotmail.com [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Cipres No. 10, Fracc. La Penuela, 98068 Zacatecas, Zac. (Mexico)

    2015-10-15

    The problems associated with insecurity and terrorism have forced to designing systems for detecting nuclear materials, drugs and explosives that are installed on roads, ports and airports. Organic materials are composed of C, H, O and N; similarly the explosive materials are manufactured which can be distinguished by the concentration of these elements. Its elemental composition, particularly the concentration of hydrogen and oxygen, allow distinguish them from other organic substances. When these materials are irradiated with neutrons nuclear reactions (n, γ) are produced, where the emitted photons are ready gamma rays whose energy is characteristic of each element and its abundance allows estimating their concentration. The aim of this study was designed using Monte Carlo methods a system with neutron source, gamma rays detector and moderator able to distinguish the presence of Rdx and urea. In design were used as moderators: paraffin, light water, polyethylene and graphite; as detectors were used HPGe and the NaI(Tl). The design that showed the best performance was the moderator of light water and HPGe, with a source of {sup 241}AmBe. For this design, the values of ambient dose equivalent around the system were calculated. (Author)

  17. Comparison of manikins with different materials by measuring the neutron dose in peripheral photonics and IMRT treatment; Comparacion de maniquies con diferentes materiales mediante la medida de dosis perifericas fotonica y neutronica en tratamiento de IMRT

    Energy Technology Data Exchange (ETDEWEB)

    Sansaloni, F.; Lagares, J. L.; Exposito, M. R.; Terron, J. A.; Nunez, L.; Barquero, R.; Sanchez-Doblado, F.

    2011-07-01

    In this study we have made measurements on four mannequins with different composition (polyethylene, more urea, nylon and a dummy stuffed with tissue, organs and real bones from a pig) in two IMRT treatment of head and abdomen. The measurement of the dose, the photon and neutron, is vital to know the probability of developing a secondary cancer due to radiation treatments.

  18. EFECTO DEL AZUL DE METILENO EN LA HIPOTENSIÓN Y BRADICARDIA ASOCIADAS A LA ADMINISTRACIÓN DE UNA DOSIS LETAL DEL VENENO TOTAL DE CASCABEL VENEZOLANA (Crotalus durissus cumanensis) EN RATAS

    DEFF Research Database (Denmark)

    Briceno, Elena; Zerpa, Hector; Ascanio, Elias;

    2010-01-01

    The effects of pre treatment with methylene blue (MB) on the cardiovascular effect caused by the administration of total venom (TV) of Crotalus durissus cumanensis was studied in adult rats, allocated into two groups: group I, six rats treated with TV (single dose: 1.5 mg/kg, IV) and group II, si...

  19. Characterization by Monte Carlo of the dose after a glass shield lead for gamma ray; Caracterizacion por Monte Carlo de la dosis tras un blindaje de vidrio de plomo para rayos gamma

    Energy Technology Data Exchange (ETDEWEB)

    Esteve Sanchez, S.; Gil Conde, M.; Contreras Gonzalez, J. L.; Rosado, J.; Pazyi, V.

    2013-07-01

    When a gamma-ray beam crosses the border between two media characterized by atomic number very different is they produce effects on the distribution of doses near the border difficult to predict with simple models. The case of rays gamma affecting a lead glass is particularly interesting for its application to shielding of common use. interested in studying the importance of the residual dose after the shield. (Author)

  20. Implementation of the technique of partial irradiation accelerated the breast with high doses (HDR) brachytherapy; Puesta en marcha de la tecnica de irradiacion parcial acelerada de la mama con braquterapia de alta tasa de dosis (HDR)

    Energy Technology Data Exchange (ETDEWEB)

    Molina Lopez, M. Y.; Pardo Perez, E.; Castro Novais, J.; Martinez Ortega, J.; Ruiz Maqueda, S.; Cerro Penalver, E. del

    2013-07-01

    The objective of this work is presents procedure carried out in our Centre for the implementation of the accelerated partial breast irradiation (APBI, accelerated partial-breast irradiation) with high-rate brachytherapy (HDR), using plastic tubes as applicators. Carried out measures, the evaluation of the dosimetric parameters analyzing and presenting the results. (Author)

  1. Caracterização da dose letal mínima por irradiação gama para Penicillium citrinum Characterization of minimum lethal dosis of gama irradiation to Penicillium citrinum

    Directory of Open Access Journals (Sweden)

    A. N. Norberg

    1993-12-01

    Full Text Available O uso das radiações ionizantes na destruição de microrganismos responsáveis pela deterioração de alimentos ou causadores de infecções ou toxinfecções alimentares, constituiu-se aplicação da energia nuclear, para fins verdadeiramente pacíficos. Penicillium citrinum é um fungo produtor de micotoxinas, responsáveis por intoxicações em humanos e animais que se utilizam de alimentos contaminados. Há escassez de informações sobre a resistência do P. citrinum à irradiação gama; assim esta pesquisa objetivou determinar a dose letal por irradiação gama para esse microrganismo. Foram irradiadas 76 suspensões, contendo aproximadamente 100.000 esporos por mililitro, com doses entre 0,2 e 2,2 KGy (KiloGray, sendo os sobreviventes re-irradiados com doses até 3,0 KGy. O fungo foi totalmente destruído com dose de 2,2 KGy. P. citrinum descendentes dos sobreviventes de 2,0 KGy, quando re-irradiados também foram totalmente destruídos com dose de 2,2 KGy. Observou-se um aumento da resistência às doses mais baixas em relação ao fungo não irradiadoThe use of nuclear power through radiation for the destruction of microrganisms which cause food decay, and toxicosis, is specifically for peaceful purposes. Penicillium citrinum is a fungus which produce mycotoxins responsible for intoxication in humans and animals as a result of eating contaminated food. There is little informations on the resistance of P. citrinum to radiation. The objective of this research is to determine the lethal dose of gama radiation for these microrganisms. Seventy six suspensions containing approximately 100,000 spores/ml received a dose of radiation between 0.2 and 2.2 KGy (KiloGray, being one sample still alive re-irradiated with doses up to 3.0 KGy. The fungus were totally destroyed with a 2.2 KGy. Seventy six suspensions containing approximately 100,000 spores/ml received a dose of radiation between 0.2 and 2.2 KGy, being one sample still alive re-irradiated with doses up to 3.0 KGy. The fungus were totally destroyed with a 2.2 KGy dose. An increase in the resistance to lower dose levels of radiation was observed, in relation to the fungus which had not received irradiation. Conclusion: the Minimum Lethal Dose (MLD of gamma irradiation, for P. citrinum is 2.2 KGy; the re-irradiation of the surviving fungus demonstrate that occur appearence of radio-resistant mutants

  2. The ferrous ammonium sulfate solid system, as dosemeter for processes at low temperatures and high doses of gamma radiation; El sistema sulfato ferroso amoniacal solido, como dosimetro para procesos a bajas temperaturas y altas dosis de radiacion gamma

    Energy Technology Data Exchange (ETDEWEB)

    Juarez C, J.M.; Ramos B, S.; Negron M, A. [ICN-UNAM, 04510 Mexico D.F. (Mexico)

    2005-07-01

    This paper presents the results obtained from a study of the radiation induced oxidation of crystalline ferrous ammonium sulfate with gamma rays at 295 K, 263 K and 77 K and dose from 0 to 300 kGy. The radiation induced decomposition of ferrous ammonium sulfate has been studied by the dissolution of the irradiated salt in 0,8 N sulfuric acid. The main product is Fe{sup 3+} and molar concentration of ferric ion was determined spectrophotometrically in the UV region at 304 nm. The optical density values showed a linear dependence with dose, indicating that the data obtained might be used to create a calibrating curve. Color in irradiated salt changes from blue to green, yellow and orange according to the absorbed dose. The accuracy and the reproducibility of the system were tested. In addition, some other characteristics make possible the use of this system as a dosimeter, similar to Fricke chemical dosemeter, at low temperatures and high dose. (Author)

  3. Valorization of the GAFCHROMIC XR-R film for radiation dose estimation in the skin; Valoracion de las peliculas Gafchromic XR-R para estimacion de dosis a piel en ''ablacion por radiofrecuencia''

    Energy Technology Data Exchange (ETDEWEB)

    Sanchez Garcia, M.; Otero Martinez, C.; Camino, X. M.; Sendon del Rio, J. R.; Luna Vega, V.; Lobato Busto, R.; Mosquera Sueiro, J.; Pombar Camean, M.

    2006-07-01

    The adequacy of the couple formed by the GAFCHROMIC XR-R film and the MICROTEK Scan Maker 8700 for skin dose determination has been evaluated. The main advantages are the ease of use the films, since it can be manipulated without special care and the ability to archive it in the dosimetric history of the patient. The main limiting factors coming from the scanner are the reproducibility over time and noise in the digitization; it is shown that this last component can be minimized at the cost of resolution. From the film itself, the limiting factors are the inter and intra film uniformity. Contributing an 6,5% to the overall uncertainty in dose determination. Overall, it has been shown that skin dose determination is possible with this film with an uncertainty below 10%. (Author)

  4. Adapting protocols of CT imaging in a pediatric emergency department. Evaluation of image quality and dose; Adaptacion de los protocolos de adquisicion de imagenes de TC pediatricos en un servicio de urgencia. Valoracion de la calidad de imagen y dosis

    Energy Technology Data Exchange (ETDEWEB)

    Batista Arce, A.; Gonzalez Lopez, S.; Catalan Acosta, A.; Casares Magaz, O.; Hernandez Armas, O.; Hernandez Armas, J.

    2011-07-01

    The purpose of this study was to assess qualitatively the picture quality in relation to the radiation dose delivered in CT studies of computer tomograph Pediatric Emergency Department of Hospital Universitario de Canarias (HUC) in order to optimize the technical parameters used these radiological examinations so as to obtain optimal image quality at the lowest possible dose.

  5. Thermal annealing of high dose radiation induced damage at room temperature in alkaline. Stored energy, thermoluminescence and coloration; Aniquilacion termica de dano inducido por irradiacion a altas dosis en haluros alcalinos a 300 k. energia almacenda. Termoluminiscencia y coloracion

    Energy Technology Data Exchange (ETDEWEB)

    Delgado, L.

    1980-07-01

    The possible relation between stored energy, thermoluminescence and colour centre annealing in gamma and electron irradiated alkali halides is studied. Thermoluminescence occurs at temperature higher than the temperature at which the main stored energy peak appears. No stored energy release is detected in additively coloured KC1 samples. Plastic deformation and doping with Ca and Sr induce a stored energy spectrum different from the spectrum observed in pure and as cleaved samples, but the amount of stored energy does not change for a given irradiation dose.Capacity of alkali halides to store energy by irradiation increases as the cation size decreases. (Author) 51 refs.

  6. Spectra and absorbed dose by photo-neutrons in a solid water mannequin exposed to a Linac of 15 MV; Espectros y dosis absorbida por fotoneutrones en un maniqui de agua solida expuesta a una Linac de 15 MV

    Energy Technology Data Exchange (ETDEWEB)

    Benites R, J. [Centro Estatal de Cancerologia de Nayarit, Servicio de Seguridad Radiologica, Calz. de la Cruz 118 Sur, 63000 Tepic, Nayarit (Mexico); Vega C, H. R. [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Apdo. Postal 336, 98000 Zacatecas (Mexico); Velazquez F, J., E-mail: jlbenitesr@prodigy.net.mx [Universidad Autonoma de Nayarit, Posgrado en Ciencias Biologico Agropecuarias, Carretera Tepic-Compostela Km 9, 63780 Jalisco-Nayarit (Mexico)

    2012-10-15

    Using Monte Carlo methods was modeled a solid water mannequin; according to the ICRU 44 (1989), Tissue substitutes in radiation dosimetry and measurements, of the International Commission on Radiation Units and Measurements; Report 44. This material Wt 1 is made of H (8.1%), C (67.2%), N (2.4%), O (19.9%), Cl (0.1%), Ca (2.3%) and its density is of 1.02 gr/cm{sup 3}. The mannequin was put instead of the patient, inside the treatment room and the spectra and absorbed dose were determined by photo-neutrons exposed to a Linac of 15 MV. (Author)

  7. Preparation and determination of kerma for Iridium 192 sources of low dose rate for brachytherapy; Preparacion y determinacion del kerma de fuentes de iridio-192 de baja tasa de dosis para braquiterapia

    Energy Technology Data Exchange (ETDEWEB)

    Tendilla, J.I.; Tovar M, V.; Mitsoura, E.; Aguilar H, F.; Alanis M, J. [Instituto Nacional de Investigaciones Nucleares, C.P. 52045-1, Salazar, Esrado de Mexico, D.F. (Mexico)

    2000-07-01

    The practice of Brachytherapy with Iridium-192 sources of low dose rate (0.4 - 0.8 Gy/h) is a technique used in the treatment of diverse illnesses. in this work the preparation, quality control and calibration are presented in terms of kerma in air of Iridium-192 using as target these recycled Iridium-Platinum wires. The targets were obtained as decayed sources of different radio therapeutical centers in the country and they were characterized by Scanning electron microscopy in order to determine their chemical composition. Subsequently it was developed an experimental design to establish the effect of neutron flux, geometrical array and irradiation time over the activity and percentage of the sources homogeneity. The homogeneity was determined by auto radiography and by Gamma spectroscopy. Once the optimal irradiation conditions were established, it is determined the apparent activity and kerma in air using a well type ionization chamber with traceability to a primary laboratory. Iridium-192 sources were obtained with an average homogeneity 96 %, apparent activity 282.129 {+-} 0.531 M Bq and kerma in air 0.03200 {+-} 0.00006 m Gy m/h A. (Author)

  8. Study of the radiation levels in low dose rate brachytherapy zones of the National Institute of Neoplastic Illnesses; Estudio de los Niveles de Radiacion en Zonas de Braquiterapia de Baja Tasa de Dosis del Instituto Nacional de Enfermedades Neoplasicas

    Energy Technology Data Exchange (ETDEWEB)

    Figueroa J, N.; Mora Y, B. [Instituto Nacional de Enfermedades Neoplasicas, Lima (Peru)]. e-mail: navorf01@yahoo.es

    2006-07-01

    The present study has as objective to evaluate the radiation levels of the Brachytherapy work areas of low dose rate (Gammateque, nurses station and of hospitalization rooms of patients RIC of 4th, 5th Floor-East) and to estimate the effective dose of the occupationally exposed personnel and the public in general. The measurements of the dose rate in these areas, were registered with a radiations monitor Inspector trademark, during a period of 60 days, without altering the routinary work conditions. The more high levels of environmental dose equivalent rate registered in the different work areas its are of 1.41 and 47.78 {mu}Sv/h rooms 1 and 2 in the Gammateque environments, in the hospitalization rooms of the 4th and 5th floor in the point 1 are of 40.77 and 23.67, {mu}Sv/h respectively and in the point 2 are of 129.19 and 39.93, {mu}Sv/h respectively, and in the nurses station of the 4th and 5th floor its are respectively of 7.62 u Sv/h and 0.45 u Sv/h. According to the carried out measurements and the permanency in the work place is possible to estimate the effective dose involved to the occupationally exposed personnel. The personnel that works in Gammateque could be receiving respectively as maximum dose 0.61 mSv/month, and the personnel that works in the nurses station of 13.17 and 0.78 mSv/year in the 4th and 5th floor. These registered differences among the two floors are due to that the 5th floor counts with the shielding systems (screen) contrary to the 4th, another of the factors is the distribution form of the patient beds RIC. We should have present that the radiation levels although in some cases it is very high, however, they are below of the permissible limits according to standards, but it is still possible to reduce even more, the radiation levels in the critical points fulfilling with the ALARA principle. (Author)

  9. Dose evaluation in occupationally exposed workers through dosimeters ring and wrist type with an anthropomorphic phantom; Evaluacion de la dosis en trabajadores ocupacionalmente expuestos a traves de dosimetros tipo anillo y de muneca con un fantoma antropomorfico

    Energy Technology Data Exchange (ETDEWEB)

    Palma, R.; Gastelo, E. [Univesidad Nacional Pedro Ruiz Gallo, Huamachuco, Lambayeque (Peru); Paucar, R.; Tolentino, D.; Herrera, J. [Complejo Hospitalario San Pablo, Lima (Peru); Armas, D., E-mail: fispalma@hotmail.com [Consorcio Proxtronics del Pacifico S. A. C., Cal. Manuela Estacio Mza. D1-2 Lote 13, San Miguel, Lima (Peru)

    2014-08-15

    In the Nuclear Medicine service of the Clinica San Pablo (Peru), the occupationally exposed workers carried out the preparation and administration of radiopharmaceuticals to patients, so it is vital to measure the equivalent dose to the hands during the procedures in order to optimize the exposure to the ionizing radiation and execute the Radiological Safety Regulation (D.S. No. 009-97-Em) and the standard IR 002.2012 of radiation protection and safety in nuclear medicine. In this paper was designed and built a hand anthropomorphic phantom made of paraffin following the description given for the standard man, later were placed dosimeters ring and wrist type UD-807 model, Panasonic brand. Then we proceeded to irradiate using vial containers of Tc-99 and I-131. The obtained results showed the difference between the equivalent dose obtained among the ring and wrist dosimeter also getting a dose of 153 mSv /year when working with {sup 99m}Tc and of 61 mSv /year when working with iodine-131. Was also demonstrated that the ring dosimeter shows the average dose received in the hand with less dispersion. It was found that under the national regulation on Requirements of Radiation Protection and Nuclear Safety in Medicine article 63, indicates that higher doses of 150 mSv /year the occupationally exposed workers should have hand dosimetry. Finally the individual dose limit of 500 mSv /year in extremities can be overcome if adequate radiation protection standards do not apply. (author)

  10. Evaluation of the equivalent dose (EUD) uniform as a parameter of quality of a plan; Evaluacion de la dosis equivalente uniform (EUD) como parametro de calidad de un plan

    Energy Technology Data Exchange (ETDEWEB)

    Garcia Molla, R.; Quiros Higueras, J. D.; Perez Calatayud, J.; Marco Blancas, N. de; Bonaque, J.

    2013-07-01

    The objective of this study was to evaluate the use of uniform equivalent dose (EUD) as a parameter of quality of dosimetric plans in radiotherapy. Has been sought a possible relationship with points in the dose volume histogram and exposed the difficulties encountered in the application of the evaluation with the EUD in clinical practice. Suggested a possible solution to these difficulties using the EUD (D98%). (Author)

  11. System for recalculation and evaluation of dose to patients after anatomical variations in external radiotherapy treatments; Sistema para recalculo y evaluacion de dosis a pacientes tras variaciones anatomicas en tratamientos de radioterapia externa

    Energy Technology Data Exchange (ETDEWEB)

    Benito Bejarano, M. A.; Saez Beltran, F.

    2013-07-01

    In external beam radiation treatments due to changes in the anatomy of the patient (usually by loss or weight gain) repeating the simulation TAC may be necessary After a few weeks from the start of treatment, to assess the dosimetric impact . In this paper we use a module of multimodal fusion to record study original simulation with other obtained during treatment, calculate the variation of dosimetry with anatomical changes suffered by the patient during the same and, if necessary, adapt the plan treatment. (Author)

  12. Raquianestesia contínua com altas doses de anestésicos locais Raquianestesia continua con altas dosis de anestésicos locales Continuous spinal anesthesia with high dose of local anesthetics

    OpenAIRE

    Luiz Eduardo Imbelloni; Savino Gasparini Neto; Eliana Marisa Ganem

    2010-01-01

    JUSTIFICATIVA E OBJETIVOS: A maior vantagem da raquianestesia contínua é o melhor controle de nível, intensidade e duração da analgesia espinal. Com o advento dos cateteres intermediários (cateter por foral da agulha) e sua baixa incidência de cefaleia e sintomas neurológicos, a técnica vem ganhando credibilidade. O objetivo de caso é relatar a possível segurança do uso do novo cateter com grande dose de bupivacaína hiperbárica a 0,5% com glicose a 1,6% associada à lidocaína 2% hiperbárica co...

  13. Determination of eye lens doses and identification of risk groups among radiation exposed workers. An Austrian pilot study; Bestimmung der Augenlinsen-Dosis und Identifizierung von Risikogruppen bei beruflich strahlenexponierten Personen. Eine Pilotstudie in Oesterreich

    Energy Technology Data Exchange (ETDEWEB)

    Stadtmann, H.; Hranitzky, C.; Willer, H. [Seibersdorf Labor GmbH, Seibersdorf (Austria). Radiation Protection Dosimetry; Strebl, F.; Ernst, G. [Seibersdorf Labor GmbH, Seibersdorf (Austria). Radiation Safety and Applications; Aspek, W. [Allgemeine Unfallversicherungsanstalt (AUVA), Wien (Austria). Abt. Unfallverhuetung und Berufskrankheitenbekaempfung (HUB)

    2015-07-01

    On European level, in 2014 the dose limit for the lens of the eye of radiation exposed workers has been reduced from 150 to 20 mSv per year (2013/59/Euratom). Data about eye lens exposition measured under realistic operational conditions of Austrian radiation exposed workers is sparse and there is no information to verify, if all professional groups identified to be at risk for elevated eye doses will remain below the new annual dose limit. Therefore, financed by the Austrian Workers Compensation Board, AUVA, a pilot study has been initiated to answer this question. Based on published information professional groups of radiation exposed workers and operational tasks with an enhanced risk of elevated eye lens doses have been identified. By dosimetric measurements with volunteers (forehead dose meters and parallel measurements with whole-body TL-dose meters above and under the lead apron) realistic lens doses will be estimated during selected radiation exposed tasks. Comparison of yielded doses will show whether a TLD outside the apron could serve as an alternative to forehead dose meters dedicated to measure eye lens doses. Measurements with leaded protective eyewear based on IEC61331 yield results for lead equivalent in good agreement with manufacturers' information. Results for eye lens doses determined by use of a RANDO head phantom and a standardized phantom simulating a body in a typical exposition situation for interventional radiologists show that wearing of leaded goggles allows for a 90% dose reduction. Under such conditions the eye lens dose is dominated by backscatter and stray radiation from the operator's head and patient body. This has to be considered for the evaluation of protective effectiveness for leaded eye wear.

  14. Doses produced in Spain as a results of radiation-based diagnosis (Projects Dopoes{sub D}omnes); Dosis producidas en Espana como consecuencia del diagnostico con radiaciones (Proyectos Dopoes{sub D}omnes)

    Energy Technology Data Exchange (ETDEWEB)

    Ruiz Cruces, R.; Ramirez Vera, M. L.; Alvarez Garcia, C.; Ferrer, N.

    2016-08-01

    The number of medical examinations and procedures that use ionizing radiation have continuously increased in recently years. More than 90% of human-generated exposures to ionizing radiation are from medical uses and the collective dose due to patient exposures is 200 times greater than the occupational dose of exposed workers. At the same time, the emergence of new technologies, the increased use of Computerized Tomography (CT)-even for pediatric patients- the development of digital radiography, interventional radiology and the new technologies in nuclear medicine with the use of hybrid PET/CT and SPECT/CT equipment have all contributed as well to an increase in the doses received by patients. This poses a challenge to the regulatory authorities in the field of radiological protection, the goal of which is to makes sure that the risks to patients are as low as possible compared to the benefits yielded by the use of ionizing radiation for medical purposes, in accordance with ALARA criteria. (Author)

  15. Pertumbuhan Semai Gmelina dengan Berbagai Dosis Pupuk Kompos pada Media Tanah Bekas Tambang Emas (Growth of Gmelina Seedling with Various Compost Fertilizer in Ex-Gold Mining Land Media

    Directory of Open Access Journals (Sweden)

    Basuki Wasis

    2011-07-01

    Full Text Available Mining activities could have negative impacts on the environment if the tailings produced were not processedproperly. Non-economic tailing is a composite of various minerals (heavy metal with sandy texture. Environmentalimpacts that might occur as a result of poor processing of tailings is a disruption of natural ecosystems asindicated by a decline in quality and productivity of the environment as a result of changes in soil morphologyand physical properties, chemical, and biological properties. One vegetative technique that could be applied torehabilitate degraded land is re-vegetation with the application of fertilizer. Compost could improve the physicalproperties, chemical, and biological properties of soil. Compost was also an agent of bioremediation so thattoxic heavy metals elements in growing medium could be eliminated or reduced. The experimental design usedin this study was Completely Randomized Design with compost applications consisting of 4 levels of treatmentwith each level of treatment consisting of 3 replications, each replication consisted of one gmelina seedling.Research showed that the application of compost would significantly affect the growth of gmelina’s height, butnot significantly affected the diameter growth. Single-dose effect of 30 g of compost would significantly affect theseedling’s height. The combination of planting and fertilizing glemina using compost could be recommended inan effort to reclaim land of ex-gold mining.Keywords: tailing, bioremediation agent, compost fertilizer, gmelina, growth of seedling

  16. Determination of the conversion coefficient for ambient dose equivalent, H(10), from air kerma measurements; Determinacion del coeficiente de conversion para la dosis equivalente ambiental, H*(10), a partir de mediciones de kerma en aire

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez J, F. [UNAM, Facultad de Ciencias, Circuito Exterior, Ciudad Universitaria, 04510 Ciudad de Mexico (Mexico); Alvarez R, J. T., E-mail: trinidad.alvarez@inin.gob.mx [ININ, Departamento de Metrologia de Radiaciones Ionizantes, Carretera Mexico-Toluca s/n, 52750 Ocoyoacac, Estado de Mexico (Mexico)

    2015-09-15

    Namely the operational magnitudes can be determined by the product of a conversion coefficient by exposure air kerma or fluence, etc. In particular in Mexico for the first time is determined the conversion coefficient (Cc) for operational magnitude Environmental Dose Equivalent H(10) by thermoluminescence dosimetry (TLD) technique. First 30 TLD-100 dosimeters are calibrated in terms of air kerma, then these dosimeters are irradiated inside a sphere ICRU type of PMMA and with the aid of theory cavity the absorbed dose in PMMA is determined at a depth of 10 mm within the sphere D{sub PMMA}(10), subsequently absorbed dose to ICRU tissue is corrected and the dose equivalent H(10) is determined. The Cc is determined as the ratio of H(10)/K{sub a} obtaining a value of 1.20 Sv Gy{sup -1} with a u{sub c}= 3.66%, this being consistent with the published value in ISO-4037-3 of 1.20 Sv Gy{sup -1} with a u{sub c}= 2%. (Author)

  17. Estimated doses related to {sup 222}Rn concentration in bunker for radiotherapy and storage of radioisotopes; Dosis estimada por concentraciones de {sup 222}Rn en bunker de radioterapia y de almacenamiento de isotopos radiactivos

    Energy Technology Data Exchange (ETDEWEB)

    Mestre, Freddy; Carrizales-Silva, Lila, E-mail: freddymest@gmail.com, E-mail: lcarriza@ivic.gob.ve [Instituto Venezolano de lnvestigaciones Cientificas, Caracas (Venezuela, Bolivarian Republic of); Sajo-Bohus, Laszlo, E-mail: sajobohus@gmail.com [Universidad Simon Bolivar, Caracas (Venezuela, Bolivarian Republic of). Laboratorio de Fisica Nuclear; Diaz, Cruz, E-mail: cruzediaZ@gmail.com [Universidad Pedagogica Experimental Libertador, Barquisimeto (Venezuela, Bolivarian Republic of). Instituto Pedagogico

    2013-07-01

    It was done a survey in radiotherapy services underground hospitals and clinics of Venezuela and Paraguay in order to estimate the concentrations of radon and its possible consequences on worker occupational exposure. Passive dosimeters were used to assess nuclear traces (NTD type CR-39 Registered-Sign ). The concentration of {sup 222}Rn is determined based on the density of traces using the calibration coefficient of 1 tr/cm{sup 2} equivalent to 0,434 Bqm{sup -3} per month of exposure. Assuming the most likely environmental conditions and the dose conversion factor equal to 9.0 x 10{sup -6} mSv h {sup -1} by Bqm{sup -3}, it was determined the average values and estimated the possible risks to health that are on average 3.0 mSva{sup -1} and 150 micro risk cancer.

  18. Use of Monte Carlo simulation software for the calculation of the effective dose in cone beam Tomography; Uso del software de simulacion Monte Carlo para el calculo de la dosis efectiva en Tomografia de haz conico

    Energy Technology Data Exchange (ETDEWEB)

    Gomes B, W. O., E-mail: wilsonottobatista@gmail.com [Instituto Federal da Bahia, Rua Emidio dos Santos s/n, Bardalho, 40301-015 Salvador, Bahia (Brazil)

    2015-10-15

    Full text: In this study irradiation geometry applicable to PCXMC and the consequent calculation of effective dose in applications of cone beam computed tomography (CBCT) was developed. Two different CBCT equipment s for dental applications were evaluated: Care Stream Cs-9000 3-Dimensional and Gendex GXCB-500 tomographs. Each protocol initially was characterized by measuring the surface kerma input and the product air kerma-area, P{sub KA}. Then, technical parameters of each of the predetermined protocols and geometric conditions in the PCXMC software were introduced to obtain the values of effective dose. The calculated effective dose is within the range of 9.0 to 15.7 μSv for Cs 9000 3-D and in the range 44.5 to 89 mSv for GXCB-500 equipment. These values were compared with dosimetric results obtained using thermoluminescent dosimeters implanted in anthropomorphic mannequin and were considered consistent. The effective dose results are very sensitive to the radiation geometry (beam position); this represents a factor of fragility software usage, but on the other hand, turns out to be a very useful tool for quick conclusions regarding the optimization process of protocols. We can conclude that the use of Monte Carlo simulation software PCXMC is useful in the evaluation of test protocols of CBCT in dental applications. (Author)

  19. Optimization of artificial neural networks for the reconstruction of the neutrons spectrum and their equivalent doses; Optimizacion de redes neuronales artificiales para la reconstruccion del espectro de neutrones y sus dosis equivalentes

    Energy Technology Data Exchange (ETDEWEB)

    Reyes A, A.; Ortiz R, J. M.; Reyes H, A.; Castaneda M, R.; Solis S, L. O.; Vega C, H. R., E-mail: art8291@hotmail.com [Universidad Autonoma de Zacatecas, Unidad Academica de Ingenieria Electrica, Av. Lopez Velarde No. 801, Col. Centro, 98000 Zacatecas (Mexico)

    2014-08-15

    In this work was used the robust design methodology of artificial neural networks to determine a good topology of net able to solve with efficiency the problems of neutrons spectrometry and dosimetry. For the design of the topology of optimized net 36 different net architectures based on an orthogonal arrangement with a configuration L{sub 9}(3{sup 4}), L{sub 4}(3{sup 2}) were trained. For the training of the neural networks, was used a computer code developed in the ambient of Mat lab programming, which automates the process and analysis of the information, reducing the time used in this activity considerably for the investigator. For the training of the propagation nets forward was utilized a neutrons spectrum compendium published by the International Atomic Energy Agency, where of the total 80% was used for the training and 20% for the test, it trained with an inverse propagation algorithm being the entrance data the count rates corresponding to the 7 spheres of the spectrometric system of Bonner spheres, as exit data, the neural network obtains the neutrons spectrum expressed in 60 energy groups and are calculated of simultaneous way 15 dosimetric quantities. (Author)

  20. First results of dose to patient in CT extracted with an automatic registration system; Primeros resultados de dosis a paciente en TC extraidas con un sistema automatico de registro

    Energy Technology Data Exchange (ETDEWEB)

    Minambres Moro, A.; Fernandez Leton, P.; Garcia Ruiz-Zorilla, J.; Perez Moreno, J. M.; Zucca Aparicio, D.

    2013-07-01

    Radiation protection of the patient in computed tomography (CT) is a priority for several reasons: the dose received during a scan is relatively high, is the diagnostic mode with greater contribution to dose to patient collective and the frequency of completion of TC is increasing rapidly the past few years. On the other hand, are currently beginning to commercially offer automated registration of dose to patient receiving dosimetric parameters of all scans performed on the equipment connected to the system. In this communication the first results are presented from two TC connected to an automatic system of this kind recently installed at our Center. (Author)

  1. Comparative study of patient doses calculated with two methods for breast digital tomosynthesis; Estudio de los valores de dosis a pacientes en examenes de tomosintesis de mama estimados con dos metodos distintos

    Energy Technology Data Exchange (ETDEWEB)

    Castillo, M.; Chevalier, M.; Calzado, A.; Garayo, J.; Valverde, J.

    2015-07-01

    In this study, the average glandular doses (DG) delivered in breast tomosynthesis examinations were estimated over a sample of 150 patients using two different methods. In method 1, the conversion factors air-kerma to DG used were those tabulated by Dance et al. and in method 2 were the ones from Feng et al. The protocol for the examination followed in the unit of this study consists in two views per breast, each view composed by a 2D acquisition and a tomosynthesis scan (3D). The resulting DG values from both methods present statistically significant differences (p=0.02) for the 2D modality and were similar for the 3D scan (p=0.22). The estimated median value of DG for the most frequent breasts (thicknesses between 50 and 60 mm) delivered in a single 3D acquisition is 1.7 mGy (36% and 17% higher than the value for the 2D mode estimated with each method) which lies far below the tolerances established by the Spanish Protocol Quality Control in Radiodiagnostic (2011). The total DG for a tomosynthesis examination (6.0 mGy) is a factor 2.4 higher than the dose delivered in a 2D examination with two views (method 1). (Author)

  2. Evaluation of dose to skin surface contamination in the factory Juzbado of fuel elements; Evaluacion de dosis a piel por contaminacion superficial en la fabrica de elementos combustibles de Juzbado

    Energy Technology Data Exchange (ETDEWEB)

    Ortiz Trujillo, D.; Agustin Perez Fonseca, A.; Alejandro Fuentes, A.

    2013-07-01

    The aim of this work is previously set a simple calculation methodology applicable to the boundary conditions surrounding the environment where skin contamination may have occurred so that you can evaluate in a simple and fast way the dose that the worker is receiving while enduring such pollution. (Author)

  3. Independent dose calculation in IMRT for the Tps Iplan using the Clarkson modified integral; Calculo independiente de dosis en IMRT para el TPS Iplan usando la integral modificada de Clarkson

    Energy Technology Data Exchange (ETDEWEB)

    Adrada, A.; Tello, Z.; Garrigo, E.; Venencia, D., E-mail: jorge.alberto.adrada@gmail.com [Instituto Privado de Radioterapia, Obispo Oro 423, X5000BFI Cordoba (Argentina)

    2014-08-15

    Intensity-Modulated Radiation Therapy (IMRT) treatments require a quality assurance (Q A) specific patient before delivery. These controls include the experimental verification in dose phantom of the total plan as well as dose distributions. The use of independent dose calculation (IDC) is used in 3D-Crt treatments; however its application in IMRT requires the implementation of an algorithm that allows considering a non-uniform intensity beam. The purpose of this work was to develop IDC software in IMRT with MLC using the algorithm proposed by Kung (Kung et al. 2000). The software was done using Matlab programming. The Clarkson modified integral was implemented on each flowing, applying concentric rings for the dose determination. From the integral of each field was calculated the dose anywhere. One time finished a planning; all data are exported to a phantom where a Q A plan is generated. On this is calculated the half dose in a representative volume of the ionization chamber and the dose at the center of it. Until now 230 IMRT planning were analyzed carried out ??in the treatment planning system (Tps) Iplan. For each one of them Q A plan was generated, were calculated and compared calculated dose with the Tps, IDC system and measurement with ionization chamber. The average difference between measured and calculated dose with the IDC system was 0.4% ± 2.2% [-6.8%, 6.4%]. The difference between the measured and the calculated doses by the pencil-beam algorithm (Pb) of Tps was 2.6% ± 1.41% [-2.0%, 5.6%] and with the Monte Carlo algorithm was 0.4% ± 1.5% [-4.9%, 3.7%]. The differences of the carried out software are comparable to the obtained with the ionization chamber and Tps in Monte Carlo mode. (author)

  4. Measurement of the photon and neutron dose in peripheral IMRT treatments in adult mannequin, adolescent and child; Medida de la dosis periferica fotonica y neutronica en tratamientos de IMRT en maniqui adulto, adolescente y nino

    Energy Technology Data Exchange (ETDEWEB)

    Sansaloni, F.; Lagares, J. L.; Exposito, M. R.; Terron, J. A.; Nunez, L.; Barquero, R.; Sanchez-Doblado, F.

    2011-07-01

    In this study we have performed measurements at different points of interest with polyethylene anthropomorphic dummies, which we call NORMA for three different patient sizes: adult, adolescent and child.

  5. Analysis of the testicular dose in patients undergoing radiotherapy for carcinoma of the prostate; Analisis de las dosis testiculares en pacientes sometidos a tratamiento radioterapico de carcinoma de prostata

    Energy Technology Data Exchange (ETDEWEB)

    Bejar Navarro, M. J.; Ordonez Marquez, J.; Hervas Moron, A.; Alvarez Rodriguez, S.; Garcia-Galloway, E.; Sanchez Casanueva, R.; Polo Rubio, A.; Rodriguez-Patron, R.; Yanowsky, K.; Gomez Dos Santos, V.

    2013-07-01

    The objectives of this work are: -Studying comparatively the doses received in testes in patients undergoing radiotherapy of prostate carcinoma with external beam radiation and brachytherapy of low rate using I-125 seeds. -Compare doses due to images of verification using Cone Beam CT (CBCT), with doses of radiotherapy treatment itself. -Determine the seminal alterations and cytogenetic after treatment with ionizing radiation (RTE or BQT) in patients diagnosed with prostate cancer and its relation with testicular dose. (Author)

  6. Monitorización de errores de medicación en dispensación individualizada mediante el método "carro centinela": comparación entre dos sistemas de distribución en dosis unitaria

    OpenAIRE

    Pérez Cebrián, Manuela D.

    2015-01-01

    Los errores de medicación (EM) en el ámbito hospitalario suponen un problema clínico relevante que implica un riesgo potencial para el paciente, a la vez que es fuente de eventuales demandas e indemnizaciones. La reducción de EM durante la Prescripción y Transcripción, principalmente tras la introducción de sistemas de prescripción electrónica, ha sido objeto de numerosos estudios. Sin embargo, la generación de EM durante la Dispensación o fases del proceso farmacoterapéutico hasta la Adminis...

  7. Pediatric fracture diagnosis. Ultra-low-dose CT with an effective dose equal to that of radiographs; Paediatrische Frakturdiagnostik. Ultra-low-dose-CT mit der effektiven Dosis von Roentgenaufnahmen

    Energy Technology Data Exchange (ETDEWEB)

    Moritz, J.D. [Universitaetsklinikum Schleswig-Holstein, Kiel (Germany). Klinik fuer Diagnostische Radiologie, Paediatrische Radiologie und Sonographie; Hoffmann, B.; Eggerking, J.; Keil, K.; Heller, M. [Universitaetsklinikum Schleswig-Holstein, Kiel (Germany). Klinik fuer Diagnostische Radiologie; Sehr, D.H. [Praxis fuer Radiologie, Merzig (Germany); Caliebe, A. [Universitaetsklinikum Schleswig-Holstein, Kiel (Germany). Inst. fuer Medizinische Informatik und Statistik; Dischinger, J. [Kiel Univ. (Germany). Norddeutsches Seminar fuer Strahlenschutz; Bolte, H. [Universitaetsklinikum Muenster (Germany). Klinik und Poliklinik fuer Nuklearmedizin

    2012-11-15

    Purpose: Computed tomography (CT) plays an important role in trauma diagnosis in children, especially for complex fractures. The aim of this study was to examine the diagnostic value of ultra-low-dose-CT (ULD-CT) with an effective dose equal to that of radiographs in an experimental study and to compare its results with those of radiographs. Materials and Methods: Limb bones of dead young pigs served as a model for pediatric bones. A total of 51 fractured and non-fractured bones were examined with a 64 multislice-CT with a standard dose protocol as gold standard, with two ultra-low-dose-protocols, and with standard radiographs with different exposures. Results: In spite of high background noise the examinations of ULD-CT were not adequate only in 2 of 204 cases. ULD-CT was slightly superior to radiographs in detection of fractures. ULD-CT could significantly better characterize the fractures than radiographs. The overall result of ULD-CT was significantly better than that of radiographs with standard exposure. Conclusion: ULD-CT with the effective dose of radiographs is successfully applicable in pediatric fracture diagnosis, and its overall result is significantly better than that of radiographs. (orig.)

  8. Dose on the entrance surface of thyroid, crystalline lens and gonads during the chest X-rays studies; Dosis en la superficie de entrada de tiroides, cristalino y gonadas durante los examenes radiologicos de torax

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez G, R.; Guerra M, J. A.; Pinedo S, A.; Hernandez O, M.; Duran M, H. A.; Salas L, M. A.; Vega C, H. R. [Universidad Autonoma de Zacatecas, Unidad Academica de Estudios Nucleares, Calle Cipres No. 10, Fracc. La Penuela, 98000 Zacatecas (Mexico); Rivera M, T. [Centro de Investigacion en Ciencia Aplicada y Tecnologia Avanzada, IPN, Av. Legaria No. 694, Col. Irrigacion, 11500 Mexico D. F. (Mexico); Azorin N, J. [Universidad Autonoma Metropolita, Unidad Iztapalapa, Av. San Rafael Atlixco 186, 09340 Mexico D. F. (Mexico)], e-mail: rgg_df@hotmail.com

    2009-10-15

    There were a measurement series in General Hospital of Fresnillo in X-rays department in areas of X-1 and X-2 ray rooms and in a neonatal intensive care unit 2, the dose was determined on the entrance surface into eyes, thyroid and gonads for patients undergoing to X-rays study of tele chest by thermoluminescent dosimetry. 5 dosemeters were used in each of the scans, found the following dose ranges 20+{sub -} 23 {mu}Gy to 350 +{sub -} 41 {mu}Gy. With results we can conclude that the used procedures and the calibration equipment are adequate. (Author)

  9. Analysis of the dose-response relationship observed in Sprekelia, Petunia and Impatiens treated with gamma radiation; Analisis de la relacion dosis-respuesta observada en Sprekelia, Petunia e Impatiens tratadas con radiacion gamma

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez J, J. [ININ, 52750 La Marquesa, Estado de Mexico (Mexico)]. e-mail: jgj@nuclear.inin.mx

    2007-07-01

    The present investigation was carried out in order to verifying if it is possible to establish one or a dose range that directly not at random produces a specific effect independently of the species that is treated. The results show that this can be possible if the ranges settle down based on the specific stocking lethal dose for each specie. (Author)

  10. Study of the heterogeneities effect in the dose distributions of Leksell Gamma Knife (R), through Monte Carlo simulation; Estudio del efecto de las heterogeneidades en las distribuciones de dosis del Leksell GammaKnife (R), mediante simulacion Monte Carlo

    Energy Technology Data Exchange (ETDEWEB)

    Rojas C, E.L. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico); Al-Dweri, F.M.O.; Lallena R, A.M. [Universidad de Granada, Granada (Spain)]. e-mail: elrc@nuclear.inin.mx

    2005-07-01

    In this work they are studied, by means of Monte Carlo simulation, the effects that take place in the dose profiles that are obtained with the Leksell Gamma Knife (R), when they are kept in account heterogeneities. The considered heterogeneities simulate the skull and the spaces of air that are in the head, like they can be the nasal breasts or the auditory conduits. The calculations were made using the Monte Carlo Penelope simulation code (v. 2003). The geometry of each one of the 201 sources that this instrument is composed, as well as of the corresponding channels of collimation of the Gamma Knife (R), it was described by means of a simplified model of geometry that has been recently studied. The obtained results when they are kept in mind the heterogeneities they present non worthless differences regarding those obtained when those are not considered. These differences are maximum in the proximities of the interfaces among different materials. (Author)

  11. Dose optimization based on linear programming implemented in a system for treatment planning in Monte Carlo; Optimizacion de dosis basada en programacion lineal implemenetada en un un sistema para la planificacion de tratamiento en Monte Carlo

    Energy Technology Data Exchange (ETDEWEB)

    Ureba, A.; Palma, B. A.; Leal, A.

    2011-07-01

    Develop a more efficient method of optimization in relation to time, based on linear programming designed to implement a multi objective penalty function which also permits a simultaneous solution integrated boost situations considering two white volumes simultaneously.

  12. Efeitos neuromusculares e cardiovasculares do pipecurônio: estudo comparativo entre diferentes doses Efectos neuromusculares y cardiovasculares del pipecuronio: estudio comparativo entre diferentes dosis Neuromuscular and cardiovascular effects of pipecuronium: a comparative study between different dose

    OpenAIRE

    Angélica de Fátima de Assunção Braga; Leandro Yoshioka; Franklin Sarmento da Silva Braga; Gloria Maria Braga Potério; José Aristeu F Frias; Rita de Cássia Rodrigues

    2008-01-01

    JUSTIFICATIVA E OBJETIVOS: O pipecurônio é um bloqueador neuromuscular não-despolarizante, com propriedades similares as do pancurônio, mas desprovido de efeitos cardiovasculares. Foram avaliados os efeitos neuromusculares, as condições de intubação traqueal e as repercussões hemodinâmicas de duas diferentes doses de pipecurônio. MÉTODO: Pacientes foram distribuídos em dois grupos de acordo com a dose de pipecurônio: Grupo I (0,04 mg.kg-1) e Grupo II (0,05 mg.kg-1). A medicação pré-anestésica...

  13. Absorbed doses profiles vs Synovia tissue depth for the Y-90 and P-32 used in radiosynoviortesis treatment; Perfiles de dosis absorbida vs profundidad de tejido sinovial para el Y-90 y el P-32 empleados en tratamiento de radiosinoviortesis

    Energy Technology Data Exchange (ETDEWEB)

    Torres B, M.B.; Ayra P, F.E. [Centro de Isotopos (Cuba); Garcia R, E. [Hospital General Docente Enrique Cabrera (Cuba); Cornejo D, N. [CPHR, (Cuba); Yoriyaz, H. [IPEN, (Brazil)]. e-mail: nestor@cphr.edu.cu

    2006-07-01

    The radiosynoviortesis treatment has been used during more of 40 years as an alternative to the chemical and surgical synovectomy to alleviate the pain and to reduce the inflammation in suffered patients of rheumatic arthropathies, haemophilic arthropathies and other articulation disorders. It consists on the injection of radioactive isotopes inside a synovial cavity. For to evaluate the dosimetry of the radiosynoviortesis treatment is of great interest to know the absorbed dose in the volume of the target (synovia). The precise calculation of the absorbed dose in the inflamed synovia it is difficult, for numerous reasons, since the same one will depend on the thickness of the synovial membrane, the size of the articular space, the structure of the synovial membrane, the distribution in the articulation, the nature of the articular liquid, etc. Also the presence of the bone and the articular cartilage, components also of the articulation, it even complicated more the calculations. The method used to evaluate the dosimetry in radioactive synovectomy is known as the Monte Carlo method. The objective of our work consists on estimating with the Monte Carlo code MCNP4B the absorbed dose of the Y-90 and the P-32 in the depth of the synovial tissue. The results are presented as absorbed dose for injected millicurie (Gy/mCi) versus depth of synovial tissue. The simulation one carries out keeping in mind several synovia areas, of 50 cm{sup 2} to 250 cm{sup 2} keeping in mind three states of progression of the illness. Those obtained values of absorbed dose using the MCNP4B code will allow to introduce in our country an optimized method of dose prescription to the patient, to treat the rheumatic arthritis in medium and big articulations using the Y-90 and the P-32, eliminating the fixed doses and fixed radionuclides for each articulation like it happens in many clinics of Europe, as well as the empiric doses. (Author)

  14. Conversion coefficients for estimation of effective dose to patients from dose area product during fluoroscopy X-ray examinations; Konversionsfaktoren zur Ermittlung der effektiven Dosis fuer Patienten aus dem Dosisflaechenprodukt bei Roentgendurchleuchtungsuntersuchungen

    Energy Technology Data Exchange (ETDEWEB)

    Gosch, D.; Kahn, T. [Universitaetsklinikum Leipzig AoeR (Germany). Klinik und Poliklinik fuer Diagnostische und Interventionelle Radiologie; Gosch, K. [Humbold Univ. Berlin, Charite (Germany). Medizinische Klinik mit Schwerpunkt fuer Psychosomatik

    2007-10-15

    Purpose: The effective dose, which is related to the stochastic radiation risk, cannot be measured directly. Therefore, conversion coefficients for estimating the effective dose for patients were calculated for fluoroscopy X-ray examinations from the dose area product which can be easily measured. Materials and Methods: Conversion coefficients were calculated using the PC-based Monte Carlo program PCXMC in software version 1.5.1. Conversion coefficients were determined for tube voltages between 60 kV and 110 kV, for additional cupper filtration up to 0.9 mm, for different projections (a. p., p. a. and lateral) and X-ray field size (between 20 cm x 20 cm and 40 cm x 40 cm in image plane) and field position (from head to leg). Results: Tube voltage, filtration and field position have a significant effect on conversion coefficients. Conversion coefficients increase as the tube voltage and filtration increase. Depending on the radiation spectrum used, the conversion coefficients may differ up to a factor of 4 for the same X-ray examination. The highest conversion coefficients were found for irradiation of the body region followed by the head and leg region. The effect of the field size and projection is moderate. Conversion coefficients for a. p. projection are higher than those for p. a. and lateral projections. Conclusion: Effective dose can be easily estimated by multiplying relevant conversion coefficients by the dose area product. Using conversion coefficients from the literature that do not take additional cupper filtration into consideration can underestimate the effective dose by a factor or up to 2 or more depending on the filtration used. (orig.)

  15. Calculation of dose distribution in the patient for verification of plans of intensity modulated radiation therapy; Calculo de la distribucion de dosis en el paciente para la verificacion de planes de radioterapia de intensidad modulada

    Energy Technology Data Exchange (ETDEWEB)

    Perez Moreno, J. M.; Zucca Aparicio, D.; Garcia Ruiz-Zorrila, J.; Fernandez Leton, J. P.; Minambres Moro, A.

    2013-07-01

    The precision in the delivery of radiation therapy treatments intensity modulated depends on, among other things, of the proper administration of the sequence of radiation calculated on the planning system. In recent years the electronic devices of imaging portal have shown as a useful tool for the measurement of dose distribution with high resolution. An algorithm has been developed to calculate the distribution of dose in the patient's Anatomy, using the accelerator as measuring equipment electronic imaging of portal In this way the acceptance criteria can be changed in the dosimetry verifications pretreatment of radiation therapy treatments, from those based on evaluation of gamma index to others based on the evaluation of the distribution of dose in the patient. (Author)

  16. Calculation Monte Carlo equivalent dose to organs in a treatment of prostate with Brachytherapy of high rate; Calculo Monte Carlo de dosis equivalente a organos en un tratamiento de prostata con braquiterapia de alta tasa

    Energy Technology Data Exchange (ETDEWEB)

    Candela-Juan, C.; Vijande, J.; Granero, D.; Ballester, F.; Perez-Calatayud, J.; Rivard, M. J.

    2013-07-01

    The objective of this study was to obtain equivalent dose to radiosensitive organs when applies brachytherapy high dose (HDR) with sources of 60 Co or 192 Go to a localized carcinoma of the prostate. The results are compared with those reported in the literature on treatment with protons and intensity modulated (IMRT) radiation therapy. (Author)

  17. On the implementation of new versions of the algorithms of calculation of dose absorbed in radiotherapy external; Sobre la implementacion de nuevas versiones de los algoritmos de calculo de dosis absorbida en radioterapia externa

    Energy Technology Data Exchange (ETDEWEB)

    Latorre-Musoll, A.; Carrasco de Fez, P.; Lizondo Gisbert, M.; Jordi-Ollero, O.; Jornet Sala, N.; Eudaldo Puell, T.; Ruiz Martinez, A.; Ribas Morales, M.

    2015-07-01

    The changes of version of the algorithms of calculation of dose absorbed in radiotherapy external should implement in a time reduced due to the pressure care. A set reduced of checks could pass by high discrepancies significant between the stones and the measures experimental, as illustrate in this work. (Author)

  18. Evaluation of the therapeutic efficacy and radiotoxicity of the conjugates {sup 177}Lu-DOTA-E-c(RGDfK){sub 2} and {sup 177}Lu-DOTA-GGC-AuNP-c[RGDfk(C)] in a murine model and their relationship with the inhibition of the angiogenic factors VEGF and HIF-1α; Evaluacion de la eficacia terapeutica y radiotoxicidad de los conjugados {sup 177}Lu-DOTA-E-c(RGDfK){sub 2} y {sup 177}Lu-DOTA-GGC-AuNP-c[RGDfK(C)] en un modelo murino y su relacion con la inhibicion de los factores angiogenicos VEGF y HIF-1α

    Energy Technology Data Exchange (ETDEWEB)

    Vilchis J, A.

    2013-07-01

    Molecular targeting therapy has become a relevant therapeutic strategy for cancer. The principle that peptide receptors can be used successfully for in vivo targeting of human cancers has been proven, and radiolabeled peptides have been demonstrated to be effective in patients with malignant tumors. Peptides based on the cyclic Arg-Gly-Asp (RGD) sequence have been designed to antagonize the function of α(v)β(3) integrin, thereby inhibiting angio genesis. The conjugation of RGD peptides to radiolabeled gold nanoparticles (AuNP) produces biocompatible and stable m ultimeric systems with target-specific molecular recognition. The aim of this research was to evaluate the therapeutic response of {sup 177}Lu-AuNP-RGD in athymic mice bearing α(v)β(3)-integrin-positive C6 gliomas and compare with that of {sup 177}Lu-AuNP or {sup 177}Lu-RGD. The radiation absorbed dose, metabolic activity (SUV, [18F]fluor-deoxy-glucose-micro PET/CT), renal radiotoxicity, renal and tumoral histological characteristics as well as tumoral VEGF and HIF-1? gene expression (by realtime polymerase chain reaction) following treatment with {sup 177}Lu-AuNP-RGD, {sup 177}Lu-AuNP or {sup 177}Lu-RGD were assessed. Of the radiopharmaceuticals evaluated, {sup 177}Lu-AuNP-RGD delivered the highest tumor radiation absorbed dose (63.8 ± 7.9 Gy) vs other treatments. These results correlated with the observed therapeutic response, in which {sup 177}Lu-AuNP-RGD significantly (p<0.05) reduced tumor progression, tumor metabolic activity, intratumoral vessels and VEGF gene expression compared to the other radiopharmaceuticals. This was consequence of high tumor retention and a combination of molecular targeting therapy (m ultimeric RGD system) and radiotherapy ({sup 177}Lu). There was a low uptake in non-target organs and no induction of renal toxicity. {sup 177}Lu-AuNP-RGD demonstrates properties suitable for use as an agent for molecular targeting radiotherapy. (Author)

  19. Proceedings of the 13. Annual meeting of the Federation of Societies on Experimental Biology; 23. Brazilian congress on biophysics; 30. Brazilian congress on pharmacology and experimental therapeutics; 33. Brazilian congress on physiology; 14. Brazilian congress on clinical research; 22. Brazilian congress on neuroscience and behaviour. Abstracts; Anais do 13. Reuniao anual da Federacao de Sociedades de Biologia Experimental; 23. Congresso brasileiro de biofisica; 30. Congresso brasileiro de farmacologia e terapeutica experimental; 33. Congresso brasileiro de fisiologia; 14. Congresso brasileiro de investigacao clinica; 22. Congresso brasileiro de neurociencias e comportamento. Resumos

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    1998-07-01

    Several aspects concerning neuroscience and behavior, compared physiology, endocrinology, pharmacology, molecular immunology and immuno diagnosis, biochemistry, genetic and toxicology of either animals, plants and microorganisms are studied. Topics such as cell membrane structures (including receptors), enzymatic assays, biological pathways, structural chemical analysis, metabolism, biological functions, blood pressure regulation are focused. The use of radiolabelled compounds, e.g. radioassay, radioimmunoassay, radioreceptor assay, are the most applied techniques.

  20. Problematiche endocrinologiche in pazienti affetti da malattie croniche e genetiche

    OpenAIRE

    Muzzi, Gianluca

    2009-01-01

    Nel primo capitolo della tesi è descritta l’evoluzione clinica e terapeutica di 4 ragazzi con diabete neonatale di tipo ricorrente. Il DMT1 è una malattia multifattoriale in cui gioca un fattore fondamentale l’autoimmunità. Per tale motivo spesso si associano al diabete tipo 1 altre malattie autoimmunitarie tra le quali la celiachia che è presente dal 3 al 10% nei bambini e negli adolescenti diabetici. Nel secondo capitolo di questa tesi è stata trattata proprio la prevalenza e la significati...

  1. A planta medicinal Aloe Vera na indústria alimentar

    OpenAIRE

    Manuel, Valentina Yolanda Lemos de Lucas

    2011-01-01

    A planta Aloe é uma erva importante vastamente utilizada na medicina tradicional. Entre estas, a Aloe vera é considerada a espécie biologicamente mais activa e é também a espécie mais comercializada. Vários estudos revelaram que os compostos das suas folhas possuem actividade terapeutica. Da folha desta planta são obtidos o látex e o gel. O látex conhecido pelas suas propriedades laxativas. O gel consiste em cerca de 99.5% de água, os restantes 0.5 – 1% de material sólido (vitaminas hidro e l...

  2. Perfil de susceptibilidade e resultados da associação de antifúngicos: um novo método

    OpenAIRE

    Santos, Rita Daniela Teixeira dos, 1986-

    2010-01-01

    As infecções fúngicas invasivas provocadas por Candida spp. constituem uma importante causa de morbilidade e mortalidade em doentes críticos. Apesar de actualmente estarem disponíveis novos fármacos, como as equinocandinas e os azoles de espectro alargado, que aumentaram as opções terapeuticas, a resistência em ambos os grupos tem sido reportada. A associação de antifúngicos com diferentes mecanismos de acção tem sido utilizada como terapêutica de salvamento, mesmo sem a existência de suporte...

  3. Luz solar, vitamina D y tuberculosis Sunlight, vitamin D and tuberculosis

    Directory of Open Access Journals (Sweden)

    A. Blanco Quirós

    2009-01-01

    Full Text Available La helioterapia fue utilizada de forma empírica desde la medicina antigua hasta el siglo XX para tratar múltiples enfermedades, entre ellas la tuberculosis y la Vit D explicó algunas de las acciones de la luz solar. En 1983, se descubrió el receptor de Vit. D y su presencia en células inmunitarias sugirió las acciones inmunitarias de la Vit. D y su posible aplicación en la patología humana. Reiteradamente se han comunicado niveles séricos descendidos de Vit. D en enfermos con tuberculosis activa o latente, aunque estos ensayos transversales no pudieron probar el sentido de la causa-efecto. Además, estudios experimentales han probado que la Vit. D mejora la defensa frente a M. tuberculosis. Recientemente se comunicó que los macrófagos infectados por M. tuberculosis, a través de los receptores TLR1,2, activan la respuesta innata y además la producción local de Vit. D activa (1,25-OH lo que explicaría la hipercalcemia y la calcificación del granuloma caseoso características de la tuberculosis. A la vista de estos datos, se ha aconsejado administrar Vit. D como terapéutica coadyuvante de la tuberculosis y en las formas resistentes. Sin embargo, los ensayos clínicos no han sido concluyentes por fallos metodológicos. Por otra parte, preocupa la conocida acción hipercalcemiante de la Vit. D y su modulación de los linfocitos Th1 que son fundamentales frente a microorganismos intracelulares, como M. tuberculosis. Sería recomendable la realización de potentes ensayos clínicos para aclarar si la terapia con Vit. D es útil y cuál es la dosis óptima a utilizar en cada situación. The heliotherapy was empirically used since antique medicine till XX century for treating many diseases, included tuberculosis, and the discovery of Vit. D has explained the effect of sunlight. The vitamin D receptor (VDR was discovered in 1983, and their presence in immune cell suggested the immune role of Vit. D and its use in human pathology were

  4. Aspectos sociopsicológicos del medio laboral asociados a la autoestima de personas que viven con VIHn Notificaciones Ver (159 Administrar  Contenido de la revista Herramientas del artículo Imprimir este artículo Metadatos de indexación Cómo citar un elemento Publicar un comentario Información Para los lectores/as Para los autores/as Para los bibliotecarios/as Acerca de los autores/as Lic. Nielvis de la Caridad Senra Pérez MSc. Mailé Contrera Betarte MSc. Yexenia Martín Chávez Encuéntranos en... Inicio / Aspectos sociopsicológicos del medio laboral asociados a la autoestima de personas que viven con VIH

    Directory of Open Access Journals (Sweden)

    Lic. Nielvis de la Caridad Senra Pérez

    2016-06-01

    Full Text Available La presente investigación consiste en un estudio cuali-cuantitativo, no experimental, que comienza siendo descriptivo y continúa siendo correlacional, describiendo y relacionando las variables: autoestima, apoyo social y conocimiento que poseen los directivos y trabajadores sobre el Virus de Inmunodeficiencia Humana. Persiguiendo como objetivo determinar la posible asociación entre los aspectos sociopsicológicos del medio laboral con la autoestima de las personas que viven con el virus. Para la realización del mismo se emplean métodos del nivel teórico, empírico y estadístico. La selección de la muestra se hace coincidir con el universo (todas las personas de Rodas que viven con el Virus de Inmunodeficiencia Humana, que se encuentran laborando por ser este uno de los municipios que más casos aporta en la provincia de Cienfuegos. Se emplean diferentes técnicas para la recogida de datos como son: entrevista en profundidad, semiestructurada, observación participante, cuestionario de apoyo social e inventario de autoestima de Coopersmith. Los resultados se muestran en tablas y figuras, así como se hace un análisis porcentual y se realiza la valoración estadística mediante la correlación de Spearman.

  5. Programa en "BASIC" para el cálculo de DL50 por el método de Probits

    OpenAIRE

    Ramiro Castro de la Mata; Alfonso Zavaleta Martínez-Vargas

    1998-01-01

    Se describe un programa en lenguaje BASIC, para plataforma MSDOS, diseñado para calcular la Dosis Letal Media (DL50) de agentes tóxicos utilizando el método de transformación en probits. Para la utilización del programa, el operador provee las dosis del agente tóxico empleado en el ensayo de toxicidad aguda letal, el número de animales utilizados en cada dosis, y el número de animales que murieron con dicha dosis; la DL50, así como los límites fiducidales al 95% de confianza. Asimismo se pres...

  6. Comunicación corta. RADIOESTIMULACIÓN DE LA GERMINACIÓN EN Stevia rebaudiana CULTIVAR KH-IAN VC-142 (EIRETÉ, MEDIANTE EL EMPLEO DE RAYOS GAMMA 60CO

    Directory of Open Access Journals (Sweden)

    María C. González

    2015-01-01

    Full Text Available El presente trabajo tuvo como objetivo evaluar el efecto de bajas dosis de rayos gamma 60 Co en la germinación de las semillas de Stevia rebaudiana . Para ello se irradiaron semillas del cultivar KH-IAN VC-142 (Eireté, con dosis de 10 a 90 Gray (Gy. Se determinó que todas las dosis empleadas incrementaron el número de semillas germinadas pero la dosis de 10 Gy fue la que provocó la mayor estimulación en la germinación de las semillas.

  7. Comunicación corta. RADIOESTIMULACIÓN DE LA GERMINACIÓN EN Stevia rebaudiana CULTIVAR KH-IAN VC-142 (EIRETÉ), MEDIANTE EL EMPLEO DE RAYOS GAMMA 60CO

    OpenAIRE

    María C. González; Héctor D. Nakayama

    2015-01-01

    El presente trabajo tuvo como objetivo evaluar el efecto de bajas dosis de rayos gamma 60 Co en la germinación de las semillas de Stevia rebaudiana . Para ello se irradiaron semillas del cultivar KH-IAN VC-142 (Eireté), con dosis de 10 a 90 Gray (Gy). Se determinó que todas las dosis empleadas incrementaron el número de semillas germinadas pero la dosis de 10 Gy fue la que provocó la mayor estimulación en la germinación de las semillas.

  8. Gamma radiation effects in Sitophilus oryzae (Linne, 1763) (Coleoptera, Curculionidae)

    International Nuclear Information System (INIS)

    Lethal effects were studied for the egg, larval and pupal stages as well as sterilization of adults of Sitophilus oryzae (L.) by the application of gamma radiation. Irradiation of pupae with an estimated dosis of 7887 ± 158 rad inhibits adult emergency. Hypotheses have been suggested that the apparent density and (or) nutrient value of food substrates decisively influence the sterilizing dosis for this insect. Thus, in rice and maize which are apparently denser and (or) of higher nutrient value than maccaroni, insects are sterilized by a dosis of 7 krad, while in maccaroni the sterilizing dosis decreases to 5 krad. (author)

  9. Loulou Services

    OpenAIRE

    Guerrero de Pablo, Francisco Javier

    2014-01-01

    Análisis, diseño, implementación, prueba y documentación de una aplicación web para gestionar la búsqueda y selección de personal doméstico y administrar los servicios de limpieza contratados por los clientes de MasVidaRed.

  10. Aplicación de la teoría de las restricciones a la administración de un departamento de recursos humanos en el sector de la salud

    OpenAIRE

    Rolando Peguero Pérez; Gisela Maria Riquenes Despaigne; Daisy Powel Nuñez; Hugo Ortiz Moncada

    2011-01-01

    La presente investigación pretende aplicar muy escuetamente la teoría de las restricciones como una moderna vía de administrar una organización, partiendo del criterio de que la administración como ciencia aún tiene una serie de limitaciones.

  11. Relación entre las cantidades de cobre y zinc administradas a pacientes graves con nutrición parenteral total y los niveles de cobre y zinc en plasma y eritrocitos Relationship between the amount of copper and zinc given to critically ill patients on total parenteral nutrition and plasma and erythrocyte copper and zinc levels

    Directory of Open Access Journals (Sweden)

    A. M. Menéndez

    2008-08-01

    Full Text Available Objetivos: Evitar tanto las complicaciones por deficiencia de zinc y de cobre como los efectos adversos del exceso en pacientes graves que requirieron nutrición parenteral, estudiando la relación entre las cantidades de zinc y de cobre administradas en las mezclas de nutrición parenteral y los cambios en algunos indicadores bioquímicos de los pacientes, con respecto a zinc y cobre. Pacientes y metodología: 29 pacientes graves, adultos, con pancreatitis o sometidos a cirugía mayor abdominal. Se determinó, al inicio y al final del tratamiento (5-21 días: cobre y zinc en las mezclas de nutrición parenteral administradas y en eritrocitos (GR, zinc en plasma y cobre en suero (Espectrometría de Absorción Atómica. Resultados (promedio ± DE, rangos: entre paréntesis: los valores de zinc y cobre en las mezclas de nutrición parenteral fueron (μg/mL: zinc: 4,2 ± 1,7 (1,8 a 9,3; cobre: 0,94 ± 0,66 (0,1 a 3,1; zinc plasmático (μg/dl: inicio 80 ± 45 (29-205; final: 122 ± 56 (37-229; zinc eritrocitario (μg/dl: inicio: 2.300 ± 1.070 (790-5280; final: 2.160± 920 (790-4.440; cobre sérico (μg/dl: inicio: 124 ± 35 (62-211; final: 128 ± 41 (60-238; cobre eritrocitario (μg/dl: inicio: 72 ± 39 (4-183; final: 70 ± 41 (9-156. Los cambios porcentuales de los niveles de zinc eritrocitario correlacionaron con el zinc (mg/d en las mezclas de nutrición parenteral (r = 0,38. Las variaciones de cobre sérico y eritrocitario correlacionaron positivamente con los valores de cobre administrado (mg/d en las mezclas de nutrición parenteral (r = 0,31 y 0,26, respectivamente. Conclusiones: Estos resultados evidenciaron que: 1 las determinaciones de zinc eritrocitario, cobre sérico o eritrocitario serían de utilidad para controlar los niveles de zinc y de cobre administrados en las mezclas de nutrición parenteral a los pacientes graves; 2 las dosis de zinc deberían ser menores a 8,1 mg/d, y 3 no sería aconsejable administrar dosis de cobre

  12. Is primaquine useful and safe as true exo-erythrocytic merontocidal, hypnozoitocidal and gametocidal antimalarial drug?

    Directory of Open Access Journals (Sweden)

    Francisco Javier López-Antuñano

    1999-10-01

    á probablemente relacionada con la cepa y las características de las poblaciones de hipnozoitos de P.vivax involucrados. Si los trabajadores de salud bien informados y calificados deciden usar primaquina en ausencia de deficiencias de enzimas y están dispuestos a hacer el seguimiento clínico, toxicológico y parasitológico, pueden administrar con seguridad una dosis diaria de 0.25 mg/kg de primaquina-base durante 14 días para la posible prevención de las recaídas por P. vivax.

  13. Know How to Use Your Asthma Inhaler

    Medline Plus

    Full Text Available ... does not support iframes Cómo usar un inhalador de dosis fija con espaciador [PDF - 343 KB] Using ... does not support iframes Cómo usar un inhalador de dosis fija (a aproximadamente una o dos pulgadas ...

  14. Pengaruh Cendawan Mikoriza Arbuskula Dan Naungan Terhadap Pertumbuhan Bibit Kayu Manis (Cinnamomum Burmanii Bl.) (The Effect Of Arbuscule Mycorrhizae Fungi And Shading On Growth Of Cinnamon Seedling [Cinnamomum Burmanii Bl.])

    OpenAIRE

    D e l v i a n

    2009-01-01

    Interaksi antara dosis inokulum mikoriza dan tingkat naungan berpengaruh terhadap pertumbuhan bibit, berat kering, rasio tajuk akar, serapan P dan persentase akar terinfeksi. Dosis mikoriza 100 g/bibit dan tingkat naungan 75% memberikan pertumbuhan yang terbaik untuk bibit kayu manis. Peningkatan naungan dari 25% sampai 75% mampu meningkat pertumbuhan bibit dengan baik. per-sep2005- (2)

  15. Radioactive emissions and their radio-ecological valuation

    International Nuclear Information System (INIS)

    For the unification of radioactive emissions and radiation exposition of persons, radio-ecological model calculations will be used. Such dosis calculations, which should better be called dosis evaluations, are used during licensing procedures and also during official reports of the Federal Government. The supposition for each radio-ecological model calculation is the complete comprehension of radioactive emissions, as they were developed during the past few years, in the Federal Republic of Germany. The emitted activities of 1975 of nuclear power plants with exhaust air and sewage, which were estimated by means of a model calculation showed that exposure as well as dosis values are laying below the limitation values. At modern plants even further below. As far as at older plants dosis values in the size of the limitation values are obtained, later inspections have proved that the model values and parameters lead to increasing dosis estimations. (orig.)

  16. Study of the absorbed dose in small fields with absence of lateral electronic balance in stereotactic radiosurgery and radiotherapy with modulated intensity; Estudio de la dosis absorbida en campos pequenos con ausencia de equilibrio electronico lateral en radiocirugia estereotaxica y radioterapia con intensidad modulada

    Energy Technology Data Exchange (ETDEWEB)

    Vargas V, M. X.

    2013-07-01

    In this thesis we develop and experimental and theoretical study, using semi analytical techniques of the physical dosimetry for small and nonstandard fields for stereotactic radiosurgery (Srs) and intensity modulated radiation therapy (IMRT), with high energy photon beams from a BrainLAB system with cones at Instituto del Cancer SOLCA (Ecuador) and a Tomo Therapy Hi-Art system at Centro Oncologico de Chihuahua (Mexico). (Author)

  17. Relative frequencies of interventional radiology procedures. Type of procedure, modality, dose, patient's gender and age. Final report; Erfassung der relativen Haeufigkeiten verschiedener Massnahmen in der interventionellen Radiologie. Art der Untersuchung, Modalitaet, Dosis, Geschlecht und Alter der Patienten fuer den stationaeren und ambulanten Bereich. Abschlussbericht

    Energy Technology Data Exchange (ETDEWEB)

    Heuser, Lothar; Bode-Schnurbus, Lucas [Bochum Univ. Klinikum (Germany). Inst. fuer Diagnostische Radiologie, Interventionelle Radiologie, Neuroradiologie und Nuklearmedizin

    2012-02-15

    The assessment of the relative frequencies of interventional radiology procedures in Germany includes the following chapters: (1) Introduction and scope. (2) Radiological interventions: diagnostics, pain therapy, liver and kidneys, vascular re-opening and extending measures, devascularization, special neuroradiologic therapies. (3) History of AGIR (workgroup vascular diseases and interventional radiology). (4) Software development. (5) Data pool. (6) Categorization of institutes. (7) Statistics: patients data; radiation protection relevant data; CT guided intervention, MR-guided interventions; ultrasound-guided interventions; process quality; retrospective analysis (2000-2003).

  18. Desarrollo de un programa de simulación basado en el método de Montecarlo para el cálculo de dosis con maniquíes divididos en voxels. Aplicaciones en tomografía computarizada

    OpenAIRE

    Salvadó Artells, Marçal

    2004-01-01

    Among the different radiodiagnostic techniques, computed tomography (CT) represents the major contribution to the collective dose. In order to have available a tool to assess and ascertain the imparted dose upon CT examinations, we have developed and validated a method to calculate radiation absorbed dose in CT examinations from images of phantoms and standard patients by using a voxel-based Monte Carlo simulation method.Simulations and measurements of radiation dose were conducted in air, wi...

  19. Efficacy of Different Rates of Sexual Pheromoneof Phthorimaea operculella (Zeller) (Lepidoptera: Gellechiidae) in Maleso of PotatoTuber Moth Captures Efectividad de Distintas Dosis de Feromona Sexual de Phthorimaea operculella (Zeller) (Lepidoptera: Gelechiidae) en la Captura de Machos de Polilla de la Papa

    OpenAIRE

    Patricia Larraín S; Michel Guillon; Julio Kalazich B.; Fernando Graña S; Claudia Vásquez R

    2007-01-01

    Potato tuber moth (PTM), Phthorimaea operculella (Zeller), widely world distributed, is one of the most serious insect pest attacking potatoes (Solanum tuberosum L.). Larvae develop in foliage and tubers of potato causing direct losses of edible product. Chemicals treatment to control this pest have shown limited efficacy, especially when larvae is under the soil. The utilization of synthetic pheromones as a tool that interferes with insects mating had been widely demonstrated in numerous mot...

  20. Automation of the monitoring in real time of the absorbed dose rate in air due to the environmental gamma radiation in Cuba; Automatizacion del monitoreo en tiempo real de la tasa de dosis absorbida en aire debido a la radiacion gamma ambiental en Cuba

    Energy Technology Data Exchange (ETDEWEB)

    Dominguez L, O.; Capote F, E.; Carrazana G, J.A.; Manzano de Armas, J.F.; Alonso A, D.; Prendes A, M.; Zerquera, J.T.; Caveda R, C.A. [CPHR, Calle 20, No. 4113 e/41 y 47, Playa, La Habana, 11300, A.P. 6195 C.P. 10600 (Cuba); Kalberg, O. [Swedish Radiation Protection Institute (SSI) (Sweden); Fabelo B, O.; Montalvan E, A. [CIAC, Camaguey (Cuba); Cartas A, H. [CEAC, Cienfuegos (Cuba); Leyva F, J.C. [CISAT (Cuba)]. e-mail: orlando@cphr.edu.cu

    2006-07-01

    The Center of Protection and Hygiene of the Radiations (CPHR) like center rector of the National Net of Environmental Radiological Surveillance (RNVRA), it has strengthened their detection capacity and of answer before a situation of radiological emergency. The measurements of the absorbed dose rate in air due to the environmental gamma radiation in the main stations of the Net are obtained in real time and the CPHR receives the data coming from these posts at one time relatively short. To improve the operability of the RNVRA it was necessary to complete the facilities of existent monitoring using 4 automatic measurement stations with probes of gamma detection, implementing in this way a measurement system on real time. On the other hand the software were developed: GenironProbeFech, to obtain the data of the probes, DataMail for the shipment of the same ones by electronic mail and GammaRed that receives and processes the data in the rector center. (Author)

  1. Monte Carlo calculation of changes in the doses due to the contrast medium in the partial irradiation for the breast cancer; Calculo Monte Carlo de cambios en la dosis debidos al medio de contraste en la irradiacion parcial para el cancer de seno

    Energy Technology Data Exchange (ETDEWEB)

    Rojas C, E.L. [ININ, Km. 36.5 Carretera Mexico-Toluca, 52750 La Marquesa Ocoyoacac, Estado de Mexico (Mexico)]. e-mail: elrc@nuclear.inin.mx

    2007-07-01

    In this work the results of calculating by Monte Carlo simulation with the Penelope code are presented, the changes that are presented in the dose, when modeling a system of treatment of partial irradiation of breast cancer. The system consists of a globe plastic with a radioactive source of {sup 192}Ir in his interior. This technique is used when it is carried out the extraction of incipient cancerous tumors and it is wanted to irradiate the tissue surrounding to the tumor extracted to make sure that sick tissue does not remain. This technique was patented about 5 years ago and it is known as partial irradiation by MammoSite(R). When the plastic ball is implanted in the cavity of the surgery, it is filled with a radio opaque solution. This substance is a solution whose concentration can to vary. One of the main components of this solution is the iodine. The on-line dose calculations, carried out by the programs associated to the brachytherapy sources and, in particular for this technique, they are very good; however, the calculations are made supposing that to have an homogeneous medium. They have been carried out studies for MC simulation with the EGSNRC code and it has been that when it takes into account the presence of the contrast solution, the results change considerably. In this work we carry out dose calculations with Penelope for different solution concentrations in the ball. The results agree in general way with those carried out in other works. (Author)

  2. Quality control for thermoluminescent dosemeters TLD-100 de Li F: Mg, Ti for high dose rate treatments using Ir-192 sources in breast, esophagus and bronchus; Control de calidad con dosimetros thermoluminiscentes TLD-100 de Li F: Mg, Ti para tratamientos de alta tasa de dosis com fuentes de Ir-192 en canceres de seno, esofago y bronchio

    Energy Technology Data Exchange (ETDEWEB)

    Torres, F. [Universidad Nacional de Colombia, Bogota (Colombia)]. E-mail: franciscotorreshoyos@yahoo.com; Plazas, M.C. [Instituto Nacional de Cancerologia, Bogota (Colombia); Cavadia, W. [Universidad de Cordoba (Colombia)

    2004-07-01

    Rods - shaped, TLD - 100, LiF: Mg,Ti thermoluminescence dosimeters are used to check duality control during breast, esophagus and bronchus cancer treatments with high rate dose and Ir -192 source. We conclude that the specificity dose in prescription points is in agreement with parameters given in international protocols. (author)

  3. Verification and analysis of the positioning of a source of brachytherapy high dose within an applicator gynecological interstitial fletcher Utrecht TC/RM; Verificacion y analysis del posicionamiento de una fuente de braquiterapia de alta tasa de dosis dentro de un aplicador ginecologico fletcher intersticial UTRECHT TC/RM

    Energy Technology Data Exchange (ETDEWEB)

    Panedo Cobos, J. M.; Garcia castejon, M. A.; Huertas Martinez, C.; Gomez-Tejedor Alonso, S.; Rincon Perez, M.; Luna Tirado, J.; Perez Casas, A. M.

    2013-07-01

    Applicators are guides that circulate and are located within the patient brachytherapy sources. Applicators can suffer mechanical deformations due to processes of sterilization or shock, which may result in that the source do not place within these very precise and coincides with the planned. In these cases the planned treatment deviate actually managed. The object of this study is to verify that the position of the source into the dispenser coincides with the planned position, with a procedure that is described. (Author)

  4. Evaluation and characterization of digital X-ray equipment for paediatric cardiology in the Hospital Gregorio Maranon; Evaluacion y caracterizacion de la dinamica de trabajo y de la dosis recibida por el paciente en la sala de hemodinamica infantil del Hospital General Universitario Gregorio Maranon

    Energy Technology Data Exchange (ETDEWEB)

    Calama Santiago, J. A.; Gonzalez Ruiz, C.; Infante Utrilla, M. A.; Zanfano Hidalgo, R.; Penedo cobos, J. M.; Sierra Diaz, F.; Olivares Munoz, M. P.

    2006-07-01

    The purchase of a digital X-Ray equipment specific for paediatric cardiology in 2003 has allowed a careful examination of the technical characteristics of these patients. This data review includes the analysis of a dose index with several variable factors such as weight, size and age of patients, purpose, type and characteristics of the study and its development over time as a results of the experience gained by the staff involved. (Author)

  5. Radiotherapy with linear accelerator in a patient with permanent pacemaker, methodology and results of dose determination in a case in vivo; Radioterapia con Linac en un paciente con marcapasos permanente, metodologia y resultados de determinacion de dosis en un caso in vivo

    Energy Technology Data Exchange (ETDEWEB)

    Diaz A, P.; Dominguez O, X.; Toledo B, V.; Nungaray, H.; Zazueta L, F., E-mail: pdiaz@hospitalsanjavier.co [Hospital San Javier, Pablo Casals No. 640, Col. Prados Providencia, 44670 Guadalajara, Jalisco (Mexico)

    2010-09-15

    This work presents the methodology used by the radiotherapy department of the Hospital San Javier in the patients handling with pacemaker. By means of dosimetry to the implant area of the pacemaker together with electrocardiography measurements during the radiotherapy sessions, the pacemaker performance is evaluated with the objective of detecting any anomaly to the same caused by electromagnetic interference and/or accumulated dose. It is necessary to follow specific protocols in these patients type that guarantee their security during the exposition to ionizing radiation since a definitive consent that allows to calculate the failure probability of pacemaker in this therapeutic condition does not exist. (Author)

  6. Comparison of the dose results in whole body and thyroid caused by {sup 131} I using the software AIDE, DOSINT and ACCUSCAN; Comparacion de los resultados de dosis en cuerpo entero y tiroides causada por {sup 131} I utilizando los softwares AIDE, DOSINT y ACCUSCAN

    Energy Technology Data Exchange (ETDEWEB)

    Quintero P, E.; Alfaro L, M.M. [ININ, 52045 Ocoyoacac, Estado de Mexico (Mexico)]. e-mail: eqp@nuclear.inin.mx

    2006-07-01

    Due to the sharp incorporation of 3.7 MBq of {sup 131} I via oral for a patient, with the purpose of obtaining a thyroid gamma gram, it makes later a pursuit on to carry out the calculation of effective dose committed using the software AIDE, DOSINT and Accuscan that possesses the National Institute of Nuclear Research (ININ) and to compare the results of these. For this study it was carried out a pursuit of the biokinetic behavior of the radioisotope in the patient's body, measuring the activity with a whole-body counter of vertical sweeping, Canberra, model Accuscan Canberra trademark. The calibration of the system it was carried out using a RMC-II Canberra trademark phantom. The patient was accounted to different intervals of time starting from April 5 up to June 30, 2005. The Accuscan II program Canberra trademark, it was acquired with the whole-body system in 1992 by the ININ. The DOSINT program was elaborated by the National Commission of Nuclear Safety and Safeguards of Mexico and proportionate to the ININ in 2000. So much the DOSINT program as the Accuscan are based on the ICRP-26/30. The AIDE program was provided by the IAEA through the project IAEA-ARCAL-RLA/9/049-LXXVII - Harmonization of procedures of internal dosimetry in 2005. This program is based on the ICRP-78. The present activity in the urine was measured later starting from the third day of the incorporation of {sup 131} I to different intervals of time until the 87 th day. The measurements were carried out using a gamma spectrometer with a Ge Hp detector and beryllium window, with 27.4% of relative efficiency and graduate armor-plating. The calibration of the system it was carried out using a multi nuclides pattern packed in Marinelli geometry of 0.5 L, prepared by the Laboratory of Radioactive Patterns (LPR) of the INlN starting from a certified solution. (Author)

  7. Differences in absorbed doses at risk organs and target tumoral of planning(PTV) in lung treatments using two algorithms of different calculations; Diferencias en las dosis absorbidas en organos de riesgo y volumen tumoral de planificacion (PTV) en tratamientos de pulmon usando dos algoritmos de calculo diferentes: pencil beam y collpased cone

    Energy Technology Data Exchange (ETDEWEB)

    Uruena Llinares, A.; Santos Rubio, A.; Luis Simon, F. J.; Sanchez Carmona, G.; Herrador Cordoba, M.

    2006-07-01

    The objective of this paper is to compare, in thirty treatments for lung cancer,the absorbed doses at risk organs and target volumes obtained between the two used algorithms of calculation of our treatment planning system Oncentra Masterplan, that is, Pencil Beams vs Collapsed Cone. For it we use a set of measured indicators (D1 and D99 of tumor volume, V20 of lung, homogeneity index defined as (D5-D95)/D prescribed, and others). Analysing the dta, making a descriptor analysis of the results, and applying the non parametric test of the ranks with sign of Wilcoxon we find that the use of Pencil Beam algorithm underestimates the dose in the zone of the PTV including regions of low density as well as the values of maximum dose in spine cord. So, we conclude that in those treatments in which the spine dose is near the maximum permissible limit or those in which the PTV it includes a zone with pulmonary tissue must be used the Collapse Cone algorithm systematically and in any case an analysis must become to choose between time and precision in the calculation for both algorithms. (Authors)

  8. Dose in the uterus of a woman, with three months of pregnancy, due to the {sup 131} I accumulated in her thyroid gland; Dosis en el utero de una mujer, con tres meses de embarazo, debida la {sup 131} I acumulado en su glandula tiroides

    Energy Technology Data Exchange (ETDEWEB)

    Vega C, H.R.; Manzanares A, E.; Hernandez D, V.M.; Arcos P, A. [Unidades Academicas de Estudios Nucleares e Ingenieria Electrica, Universidad Autonoma de Zacatecas, C. Cipres 10, Fracc. La Penuela, 98068 Zacatecas (Mexico)]. e-mail: fermineutron@yahoo.com

    2006-07-01

    In this study the absorbed dose by the uterus of a woman with three months of pregnancy to who was applied a dose of {sup 131} I that was accumulated in the thyroid gland is determined. The absorbed dose was obtained by means of Monte Carlo calculations developing a detailed three-dimensional model of the pregnant one, where they have been included most of the organs. The absorbed dose also was calculated by means of a simple procedure. To verify the calculated results it was carried out an experiment where was constructed a phantom of the neck, in this was included the thyroid with {sup 131} I and the exposure was measured at different distances of the neck; this was related with the dose. Of the Monte Carlo calculation is obtained that for each mCi of {sup 131} I that is retained in the mother's thyroid, the uterus absorbs a dose of 6.80 E(-11) Gy. When comparing the results, it was found that the simple calculation throws a result 29 times superior to that of the dose obtained by means of Monte Carlo. When applying a correction for the effect of the absorption of the gamma photons by the mother's body an absorbed dose in the uterus was obtained that is 0.16 times superior to the Monte Carlo calculation. Of the experimental phase it is verified that the values calculated by means of the simple method are equal to those experimentally measured. (Author)

  9. UREASE ACTIVITY AND NITROGEN MINERALIZATION KINETICS AS AFFECTED BY TEMPERATURE AND UREA INPUT RATE IN SOUTHERN CHILEAN ANDISOLS Efecto de la temperatura y dosis de fertilización con urea sobre la actividad ureasa y cinética de mineralización de nitrógeno en Andisoles del Sur de Chile

    OpenAIRE

    Paula Cartes; Alejandra A Jara; Rolando Demanet; María de la Luz Mora

    2009-01-01

    Incubation studies were carried out to evaluate the effect of temperature and urea supply level on both the urease activity and the kinetics of N mineralization in two Andisols of Southern Chile. Our results showed that urease activity was higher in Piedras Negras soil (PNS) than Freiré soil (FS) at 24 and 48 h, and the enzyme was activated when the temperature increased from 5 to 21 °C. Urease activity followed a simple Michaelis-Menten kinetics. In PNS, the Michaelis Menten constant (Km) de...

  10. Dose-response relationship of induction kinetics of In vivo DNA damage and repair in mouse leukocytes exposed to gamma radiation; Relacion dosis-respuesta de la cinetica de induccion de dano y reparacion del ADN In vivo en leucocitos de raton expuestos a radiacion gamma

    Energy Technology Data Exchange (ETDEWEB)

    Mendiola C, M.T.; Morales, R.P. [Instituto Nacional de Investigaciones Nucleares, Gerencia de Investigacion Basica, Departamento de Biologia, A.P. 18-1027, 11801 Mexico D.F. (Mexico)

    2000-07-01

    The Unicellular electrophoresis in gel technique is a useful tool in the determination of simple ruptures and labile sites to the alkali in DNA of eucariontes cells. The determination of the induction kinetics of damage and repair of DNA can give more information. The objective of this work was to determine whether the analysis of the area under the damage/repair induction kinetics curve in comets percent or the comets frequency in the two peaks of maximum induction is adequate for determining the dose-response relationship. The mice were exposed at the doses of 0.5, 1.0, 2.0 Gy. (Author)

  11. Image quality control of mammography equipment -Mammography System MX-300- of the Teachers Hospital of UNSA and dose measurement in breasts with radiographic films; Control de calidad de imagen del equipo de mamografia -Mammography System MX-300- del Hospital de Docentes de la UNSA y medicion de dosis en mamas con peliculas radiograficas

    Energy Technology Data Exchange (ETDEWEB)

    Quispe F, L. K.; Vega R, J., E-mail: karinaqflores839@gmail.com [Universidad Nacional de San Agustin, Escuela Profesional de Fisica, Arequipa (Peru)

    2015-10-15

    This work is part of medical imaging for the evaluation of quality. Will have an accredited breast phantom Rmi-156 that allows evaluating the image quality of mammography equipment and through a series of techniques and processes that will submit to mammography films we obtain characteristic curves, which allows to evaluate different parameters that will serve for our study. Images were acquired with different k Vp and m As of the equipment, also with different thicknesses of the breast phantom. Also we want to use the lowest possible dose for obtaining our images. In this paper we develop a simple protocol that aims to unify the conditions under which are acquired the images for later evaluation. By obtaining these characteristic curves demonstrate that the Kodak film is the most suitable for our study because it requires lower dose for obtaining our images. (Author)

  12. Estimation of the contribution of neutrons to the equivalent dose for personnel occupationally exposed and public in medical facilities: X-ray with energy equal or greater than 10MV; Estimacion de la contribucion por neutrones a la dosis equivalente para personal ocupacionalmente expuesto y publico en instalaciones de uso medico: rayos X de energia igual y/o superior a 10MV

    Energy Technology Data Exchange (ETDEWEB)

    Gonzalez, Alfonso Mayer; Jimenez, Roberto Ortega; Sanchez, Mario A. Reyes, E-mail: amgesfm@hotmail.com, E-mail: rojimenez@cnsns.gob.mx [Comision Nacional de Seguridad Nuclear y Salvaguardias (CNSNS), Mexico, D.F. (Mexico); Moranchel y Mejia, Mario, E-mail: mmoranchel@ipn.mx [Instituto Politecnico Nacional (ESFM/IPN), Mexico, D.F. (Mexico). Escuela Superior de Fisica y Matematicas. Departamento de lngenieria Nuclear

    2013-07-01

    In Mexico the use of electron accelerators for treating cancerous tumors had grown enormously in the last decade. When the treatments are carried out with X-ray beam energy below 10 MV the design of the shielding of the radioactive facility is determined by analyzing the interaction of X-rays, which have a direct impact and dispersion, with materials of the facility. However, when it makes use of X-ray beam energy equal to or greater than 10 MV the neutrons presence is imminent due to their generation by the interaction of the primary beam X-ray with materials head of the accelerator and of the table of treatment, mainly. In these cases, the design and calculation of shielding considers the generation of high-energy neutrons which contribute the equivalent dose that public and Occupationally Staff Exposed (POE) will receive in the areas surrounding the facility radioactive. However, very few measurements have been performed to determine the actual contribution to the neutron dose equivalent received by POE and public during working hours. This paper presents an estimate of the actual contribution of the neutron dose equivalent received by public and POE facilities in various radioactive medical use, considering many factors. To this end, measurements were made of the equivalent dose by using a neutron monitor in areas surrounding different radioactive installations (of Mexico) which used electron accelerators medical use during treatment with X-ray beam energy equal to or greater than 10 MV. The results are presented after a statistical analysis of a wide range of measures in order to estimate more reliability real contribution of the neutron dose equivalent for POE and the public. (author)

  13. Characterization of a dose verification system dedicated to radiotherapy treatments based on a silicon detector multi-strips; Caracterizacion de un sistema de verificacion de dosis dedicado a tratamientos de radioterapia basado en un detector de silicio de multi-tiras

    Energy Technology Data Exchange (ETDEWEB)

    Bocca, A.; Cortes Giraldo, M. A.; Gallardo, M. I.; Espino, J. M.; Aranas, R.; Abou Haidar, Z.; Alvarez, M. A. G.; Quesada, J. M.; Vega-Leal, A. P.; Perez Neto, F. J.

    2011-07-01

    In this paper, we present the characterization of a silicon detector multi-strips (SSSSD: Single Sided Silicon Strip Detector), developed by the company Micron Semiconductors Ltd. for use as a verification system for radiotherapy treatments.

  14. Evolución de los componentes de carbono, nitrógeno y propiedades edáficas de un suelo agrícola mediterráneo tras la aplicación de altas dosis de residuos orgánicos biodegradables

    OpenAIRE

    Jorge Mardomingo, Ignacio

    2014-01-01

    La producción de residuos orgánicos biodegradables (lodos de depuradora y residuos sólidos urbanos) y su posterior gestión se ha convertido en uno de los temas que mayor atención genera en la política ambiental comunitaria. Según la Comisión Europea, el uso de estos residuos como enmienda agrícola se considera como la solución menos costosa. Sin embargo, la aplicación de estos residuos origina variaciones en los componentes y propiedades edáficas, que provocan unos efectos ambientales que no ...

  15. Simulation of dose deposition in heterogeneities in the human body, using the Penelope code for photons beams of energies of a linear accelerator; Simulacion de la deposicion de dosis en las heterogeneidades del cuerpo humano, usando el codigo Penelope para haces de fotones de energias de un acelerador lineal

    Energy Technology Data Exchange (ETDEWEB)

    Cardena R, A. R.; Vega R, J. L.; Apaza V, D. G., E-mail: cardroj@yahoo.es [Universidad Nacional de San Agustin, Av. Independencia s/n, Arequipa (Peru)

    2015-10-15

    The progress in cancer treatment systems in heterogeneities of human body has had obstacles by the lack of a suitable experimental model test. The only option is to develop simulated theoretical models that have the same properties in interfaces similar to human tissues, to know the radiation behavior in the interaction with these materials. In this paper we used the Monte Carlo method by Penelope code based solely on studies for the cancer treatment as well as for the calibration of beams and their various interactions in mannequins. This paper also aims the construction, simulation and characterization of an equivalent object to the tissues of the human body with various heterogeneities, we will later use to control and plan experientially doses supplied in treating tumors in radiotherapy. To fulfill the objective we study the ionizing radiation and the various processes occurring in the interaction with matter; understanding that to calculate the dose deposited in tissues interfaces (percentage depth dose) must be taken into consideration aspects such as the deposited energy, irradiation fields, density, thickness, tissue sensitivity and other items. (Author)

  16. Evaluation of the absorbed dose to the lungs due to Xe{sup 133} and Tc{sup 99m} (MAA); Evaluacion de la dosis absorbida en los pulmones debido al Xe{sup 133} y Tc{sup 99m} (MAA)

    Energy Technology Data Exchange (ETDEWEB)

    Vazquez A, M.; Murillo C, F.; Castillo D, C.; Sifuentes D, Y.; Sanchez S, P. [Universidad Nacional de Trujillo, Av. Juan Pablo II s/n, Trujillo (Peru); Rojas P, E. [Instituto Peruano de Energia Nuclear, Av. Canada 1470, Lima (Peru); Marquez P, F., E-mail: marvva@hotmail.com [Instituto Nacional de Enfermedades Neoplasicas, Av. Angamos 2520, Lima (Peru)

    2015-10-15

    The absorbed dose in lungs of an adult patient has been evaluated using the biokinetics of radiopharmaceuticals containing Xe{sup 133} or Tc{sup 99m} (MAA). The absorbed dose was calculated using the MIRD formalism, and the Cristy-and Eckerman lungs model. The absorbed dose in the lungs due to {sup 133}Xe is 0.00104 mGy/MBq. Here, the absorbed dose due to remaining tissue, included in the {sup 133}Xe biokinetics is not significant. The absorbed dose in the lungs, due Tc{sup 99m} (MAA), is 0.065 mGy/MBq. Approximately, 4.6% of the absorbed dose is due to organs like liver, kidneys, bladder, and the rest of tissues, included in the Tc{sup 99m} biokinetics. Here, the absorbed dose is very significant to be overlooked. The dose contribution is mainly due to photons emitted by the liver. (Author)

  17. Evaluation of the absorbed dose to the kidneys due to Tc{sup 99m} (DTPA) / Tc{sup 99m} (Mag3) and Tc{sup 99m} (Dmsa); Evaluacion de la dosis absorbida en los rinones debido al Tc{sup 99m} (DTPA) / Tc{sup 99m} (MAG3) y Tc{sup 99m} (DMSA)

    Energy Technology Data Exchange (ETDEWEB)

    Vasquez A, M.; Murillo C, F.; Castillo D, C.; Rocha J, J.; Sifuentes D, Y.; Sanchez S, P. [Universidad Nacional de Trujillo, Av. Juan Pablo II s/n, Trujillo (Peru); Idrogo C, J.; Marquez P, F., E-mail: marvva@hotmail.com [Instituto Nacional de Enfermedades Neoplasicas, Av. Angamos 2520, Lima (Peru)

    2015-10-15

    The absorbed dose in the kidneys of adult patients has been assessed using the biokinetics of radiopharmaceuticals containing Tc{sup 99m} (DTPA) / Tc{sup 99m} (Mag3) or Tc{sup 99m} (Dmsa).The absorbed dose was calculated using the formalism MIRD and the Cristy-Eckerman representation for the kidneys. The absorbed dose to the kidneys due to Tc{sup 99m} (DTPA) / Tc{sup 99m} (Mag3), are given by 0.00466 mGy.MBq{sup -1} / 0.00339 mGy.MBq{sup -1}. Approximately 21.2% of the absorbed dose is due to the bladder (content) and the remaining tissue, included in biokinetics of Tc{sup 99m} (DTPA) / Tc{sup 99m} (Mag3). The absorbed dose to the kidneys due to Tc{sup 99m} (Dmsa) is 0.17881 mGy.MBq{sup -1}. Here, 1.7% of the absorbed dose is due to the bladder, spleen, liver and the remaining tissue, included in biokinetics of Tc{sup 99m} (Dmsa). (Author)

  18. Evaluation of absorbed dose in studies of renal function due to {sup 123}I/{sup 131}I (hippuran) e {sup 111}In (DPTA); Evaluacion de la dosis absorbida durante estudios de la funcion renal debido al {sup 123}I/{sup 131}I (hippuran) e {sup 111}In (DPTA)

    Energy Technology Data Exchange (ETDEWEB)

    Vasquez, M.V.; Castillo, C.E.; Rojas, R.; Cabrera, C.; Abanto, D.; Morgan, A. [Universidad Nacional de Trujillo (UNT), Area de Fisica Medica, Trujillo (Peru); Diaz, E.E., E-mail: marvva@hotmail.com [Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre (Brazil)

    2015-07-01

    The absorbed dose of the kidneys during renal function studies of adult patients is estimated through biokinetics of radiopharmaceuticals containing the {sup 123}I/{sup 131}I (hippuran) e {sup 111}In (DPTA). Using the methodology MIRD and representation Cristy-Eckerman for adult kidneys, it is shown that dosimetric contributions of organs of biokinetics {sup 123}I/{sup 131}I (hippuran) e {sup 111}In (DPTA) are significant, in estimative of dose for renal function studies. Dosimetric contributions (body and whole bladder, kidneys excluding) are given by 11.90% (for {sup 123}I), 4.97% (for {sup 131}I) and 28.32% (for {sup 111}In). In all cases, the dosimetric contributions are mainly due to photons issued by the whole body.

  19. Evaluation of the absorbed dose during studies of the renal function due to I{sup 123} / I{sup 131} (hippuran) and In{sup 111} (DTPA); Evaluacion de la dosis absorbida durante estudios de la funcion renal debido a I{sup 123} / I{sup 131} (hippuran) e In{sup 111} (DPTA)

    Energy Technology Data Exchange (ETDEWEB)

    Vasquez, M.; Castillo, C.; Sarachaga, R.; Rojas, R.; Zelada, L.; Melendez, J.; Gomez, M. [Universidad Nacional de Trujillo, Av. Juan Pablo II s/n, Ciudad Universitaria, Trujillo (Peru); Diaz, E., E-mail: marvva@hotmail.com [Universidade Federal do Rio Grande do Sul, Av. Paulo Gamma 110, Bairro Farropilhas, Porto Alegre, RS 90040-060 (Brazil)

    2014-08-15

    Using the methodology MIRD and representation Cristy-Eckerman for kidneys, bladder, and whole body as organs of the bio-kinetics of I{sup 123} / I{sup 131} (hippuran) and the In{sup 111} (D PTA), the absorbed dose for studies of the renal function of adults due to the I{sup 123} is 0,0071 mGy/MBq where 88.16% corresponds to its auto-dose and 11,96% to the organs of their bio-kinetics; while for the I{sup 131} their dose is 0,032 mGy/MBq where 95,03% corresponds to its auto-dose and 4,97% to the organs of their bio-kinetics. For the In{sup 111} their dose is 0,0168 mGy/MBq where 71,68% corresponds to their auto-dose and 28,32% to the organs of their bio-kinetics. In all the cases the dosimetric contributions of the organs of the bio-kinetics (whole body and urinary bladder) are very significant, and this fundamentally is due to the photons of the whole body. (Author)

  20. Administración de dosis elevadas de vitamina E en ratas adultas con síndrome metabólico experimental: efecto sobre el estrés oxidativo Administration of high doses of vitamin E in adult rats with experimental metabolic syndrome: effect on oxidative stress

    Directory of Open Access Journals (Sweden)

    ML Wallinger

    2011-06-01

    Full Text Available Introducción: El consumo crónico de fructosa en ratas induce la producción de síndrome metabólico. Objetivo: Evaluar en el Síndrome Metabólico Experimental (entendido como la presencia de al menos 3 de los parámetros alterados, el efecto de la administración de vitamina E sobre el nivel de lipoperoxidación en el plasma y en los tejidos. Materiales y métodos: Se estudiaron ratas Wistar machos, divididas en 4 grupos: a control (C; b control suplementadas con vitamina E (CvE; c fructosa (F; d fructosa suplementadas con vitamina E (FvE. Las dietas fueron elaboradas según las indicaciones de American Institute of Nutricion del año 1993 (AIN 93, reemplazándose en los grupos F y FvE parcialmente la fuente de carbohidratos. Se suplementó a los grupos CvE y FvE con 50 mg/día de vitamina E acetato (1360 IU/g. Se controlaron periódicamente: glucemia basal, glucemia post-prandial, prueba de tolerancia oral a la glucosa (PTOG, insulinemia, trigliceridemia, colesterolemia y presión arterial, para comprobar la aparición de los parámetros alterados del síndrome metabólico. Para medir el nivel de lipoperoxidación se determinaron las sustancias reactivas al ácido tiobarbitúrico (TBARS en plasma y tejidos. Análisis estadístico: test T y ANOVA. Resultados: Se comprobó la presencia de síndrome metabólico en el 100 % de las ratas estudiadas. Los TBARS en plasma (microlmol/l (F vs FvE arrojaron los siguientes resultados: 2,203 ± 0,142 vs 1,836 ± 0,05818, y 2,265 ± 0,1040 vs 1,915 ± 0,05506 a las 6 y 14 semanas respectivamente (p<0,05 ; TBARS en corazón (nanomol/ gr de proteína (F vs FvE: 137,6± 5,187 vs 104,7 ± 8,277 (p<0,01 ;TBARS en Hígado (nanomol/ gr de proteína (F vs FvE: 171,6 ± 8,716 vs 124,9 ± 4,575 (p< 0,001. Conclusión: La administración de vitamina E disminuyó significativamente el nivel de lipoperoxidación tanto en plasma como en homogenatos de tejidos.

  1. Measurement of the dose by dispersed radiation in a lineal accelerator using thermoluminescent dosimeters of CaSO{sub 4}:Dy; Medicion de la dosis por radiacion dispersa en un acelerador lineal usando dosimetros termoluminiscentes de CaSO{sub 4}:Dy

    Energy Technology Data Exchange (ETDEWEB)

    Chavez C, N.; Torijano, E.; Azorin, J. [Universidad Autonoma Metropolitana, Unidad Iztapalapa, Av. San Rafael Atlixco 186, Col. Vicentina, 09340 Mexico D. F. (Mexico); Herrera, A. [ISSSTE, Hospital Nacional 20 de Noviembre, Eje 7 Sur Felix Cuevas Esq. Av. Coyoacan, Col. del Valle, 03229 Mexico D. F. (Mexico)

    2014-08-15

    The thermoluminescence (Tl) is based on the principle of the luminescent in a material when is heated below their incandescence temperature. Is a technique very used in dosimetry that is based on the property that have most of the crystalline materials regarding the storage of the energy that they absorb when are exposed to the ionizing radiations. When this material has been irradiated previously, the radioactive energy that contains is liberated in form of light. In general, the principles that govern the thermoluminescence are in essence the same of those responsible for all the luminescent processes and, this way, the thermoluminescence is one of the processes that are part of the luminescence phenomenon. For this work, the dispersed radiation was measured in the therapy area of the lineal accelerator of medical use type Elekta, using thermoluminescent dosimeters of CaSO{sub 4}:Dy + Ptfe developed and elaborated in the Universidad Autonoma Metropolitana, Unidad Iztapalapa. With the dosimeters already characterized and calibrated, we proceeded to measure the dispersed radiation being a patient in treatment. The results showed values for the dispersed radiation the order of a third of the dose received by the patient on the treatment table at 30 cm of the direct beam and the order of a hundredth in the control area (4 m of the direct beam, approximately). The conclusion is that the thermoluminescent dosimeters of CaSO{sub 4}: Dy + Ptfe are appropriate to measure dispersed radiation dose in radiotherapy. (author)

  2. A mixture of Lactobacillus plantarum CECT 7315 and CECT 7316 enhances systemic immunity in elderly subjects: A dose-response, double-blind, placebo-controlled, randomized pilot trial Una mezcla de Lactobacillus plantarum CECT 7315 y CECT 7316 mejora la inmunidad sistémica en ancianos: Un ensayo aleatorio piloto, de dosis-respuesta, doble ciego y controlado con placebo

    OpenAIRE

    J. Mañé; Pedrosa, E; V. Lorén; Gassull, M A; J. Espadaler; J. Cuñé; S. Audivert; M. A. Bonachera; Cabré, E

    2011-01-01

    Background & aim: Immunosenescence can increase morbi-mortality. Lactic acid producing bacteria may improve immunity and reduce morbidity and mortality in the elderly. We aimed to investigate the effects of a mixture of two new probiotic strains of Lactobacillus plantarum-CECT 7315 and 7316- on systemic immunity in elderly. Methods: 50 institutionalized elderly subjects were randomized, in a double-blind fashion, to receive for 12 weeks 1) 5·10(8) cfu/day of L. plantarum CECT7315/7316 ("low p...

  3. Analysis of equivalent dose (H) starting from the exposition (X) received for patient families in myocardial perfusion study with {sup 99m}Tc-Sestamibi; Analisis de dosis equivalente (H) a partir de la exposicion (X) recibida por familiares de pacientes en estudio de perfusion miocardica con {sup 99m}Tc-Sestamibi

    Energy Technology Data Exchange (ETDEWEB)

    Martinez H, I.; Vazquez E, R.; Jimenez A, L., E-mail: irmarinc@yahoo.com.m [Instituto Nacional de Cardiologia Ignacio Chavez, Departamento de Cardiologia Nuclear, Juan Badiano No. 1, Colonia Seccion XVI, 14080 Mexico D. F. (Mexico)

    2010-09-15

    The myocardial perfusion study with {sup 99m}Tc-Sestamibi has the major indication frequency for the coronary arterial illness diagnostic, due to its high sensibility and specificity. The patient families that are exposed to this study also receive the radiation of the injected radiopharmaceutical. The punctual source model (Psm) is generally used for the absorbed dose calculation of the radiation coming from patients under any procedure with radiopharmaceuticals. The objective of this study was to compare the equivalent doses calculated theoretically (Dat) by means of Psm, regarding the measurements that routinely are made by means of a detector Geiger (Dam), as well as to quantify the maxim equivalent dose to which they are exposed the families of the subjected patients to this procedure. 30 voluntary patients were evaluated with clinical indication for myocardial perfusion study with {sup 99m}Tc-Sestamibi with acquisition protocol of 1 day: Rest-effort, with dose of 15-30 mCi (555-1110 mBq) respectively. Immediate to each injection of {sup 99m}Tc-Sestamibi was calculated the Dat, using the equation that the Psm describes, considering a distance of 1 meter; and the exposition speed was measured by means of a detector Geiger at a distance 1 meter to the heart height. The measurements comparison (Dat vs Dam) was realized by means of the test statistical t-student for independent samples, considering a significance level p{<=}0.05. For the data of the second injection, was realized a regression analysis to evaluate the lineal correlation among both measurements. Immediately after the injection of 15 mCi (555 mBq) of {sup 99m}Tc-Sestamibi, the values of the Dam (1.37{+-}0.43 mrem, 13.7{+-}4.3 {mu}Sv) they differ significantly of the Dat (1.04 mrem, p<0.05) (10.4 {mu}Sv). The second injection of 30 mCi (1110 mBq) of {sup 99m}Tc-Sestamibi was carried out in an average time of 2.57{+-}0.02 hr, having the patients group a calculated initial activity of 11.14{+-}0.76 mCi (412.2{+-}28.12 mBq). Differences were not observed statistically significant between the Dam (2.76{+-}0.87 mrem) regarding the Dat (2.86{+-}0.05 mrem, p=0.58) (28.6{+-}0.5 {mu}Sv), after the second injection of the radiopharmaceutical. However, the Pearson correlation index between both measurements was of 0.22 with a significance of p=0.12. Assuming that later to the second injection the patient familiar stays at a distance of 1 meter during the 3 remaining hours of the study, the dose absorbed by the familiar calculated by the Psm is of 6.93{+-}0.13 mrem (69.3{+-}0.13 {mu}Sv) Conclusions. The Dat and Dam values are not significant different; however the regression analysis establish the necessity to carry out a variability and multiplication analysis of the measurements that are realized routinely and/or to explore the equivalent dose calculation through another different model to the Psm. The maxim equivalent dose calculated for a familiar that accompanies a patient with myocardial perfusion study - {sup 99m}Tc-Sestamibi is similar to the exposition of 8.4 days to the natural radiation of depth, considering that the natural radiation is of 300 mrem/year (3 mSv/year); for what this study does not represent any risk, what diminishes even more the relationship cost-benefit of this procedure. (Author)

  4. Estimation of the contribution by neutrons to the equivalent dose for exposed occupationally personnel and people in medical use facilities: X rays of equal or superior energy to 10 MV; Estimacion de la contribucion por neutrones a la dosis equivalente para personal ocupacionalmente expuesto y publico en instalaciones de uso medico: rayos X de energia igual y/o superior a 10 MV

    Energy Technology Data Exchange (ETDEWEB)

    Ortega J, R.; Reyes S, M. A. [Comision Nacional de Seguridad Nuclear y Salvaguardias, Dr. Jose Ma. Barragan 779, Col. Narvarte, 03020 Mexico D. F. (Mexico); Moranchel y R, M., E-mail: rojimenez@cnsns.gob.mx [IPN, Escuela Superior de Fisica y Matematicas, Departamento de Ingenieria Nuclear, Av. Instituto Politecnico Nacional s/n, U. P. Adolfo Lopez Mateos, Edif. 9, Col. San Pedro Zacatenco, 07738 Mexico D. F. (Mexico)

    2013-10-15

    In Mexico the use of electron accelerators for treating cancerous tumors had grown enormously in the last decade. When the treatments are carried out with X-ray beam energy below 10 MV the design of the shielding of the radioactive facility is determined by analyzing the interaction of X-rays, which have a direct impact and dispersion, with materials of the facility. However, when it makes use of X-ray beam energy equal to or greater than 10 MV the neutrons presence is imminent due to their generation by the interaction of the primary beam X-ray with materials head of the accelerator and of the table of treatment, mainly. In these cases, the design and calculation of shielding considers the generation of high-energy neutrons which contribute the equivalent dose that public and occupationally staff exposed (POE) will receive in the areas surrounding the facility radioactive. However, very few measurements have been performed to determine the actual contribution to the neutron dose equivalent received by POE and public during working hours. This paper presents and estimate of the actual contribution of the neutron dose equivalent received by public and POE facilities in various radioactive medical use, considering many factors. To this end, measurements were made of the equivalent dose by using a neutron monitor in areas surrounding different radioactive installations (of Mexico) which used electron accelerators medical use during treatment with X-ray beam energy equal to or greater than 10 MV. The results are presented after a statistical analysis of a wide range of measures in order to estimate more reliability real contribution of the neutron dose equivalent for POE and the public. (author)

  5. Implementation of a model of atmospheric dispersion and dose calculation in the release of radioactive effluents in the Nuclear Centre; Implementacion de un modelo de dispersion atmosferica y calculo de dosis en la liberacion de efluentes radiactivos en el Centro Nuclear

    Energy Technology Data Exchange (ETDEWEB)

    Cruz L, C. A.

    2015-07-01

    In the present thesis, the software DERA (Dispersion of Radioactive Effluents into the Atmosphere) was developed in order to calculate the equivalent dose, external and internal, associated with the release of radioactive effluents into the atmosphere from a nuclear facility. The software describes such emissions in normal operation, and not considering the exceptional situations such as accidents. Several tools were integrated for describing the dispersion of radioactive effluents using site meteorological information (average speed and wind direction and the stability profile). Starting with the calculation of the concentration of the effluent as a function of position, DERA estimates equivalent doses using a set of EPA s and ICRP s coefficients. The software contains a module that integrates a database with these coefficients for a set of 825 different radioisotopes and uses the Gaussian method to calculate the effluents dispersion. This work analyzes how adequate is the Gaussian model to describe emissions type -puff-. Chapter 4 concludes, on the basis of a comparison of the recommended correlations of emissions type -puff-, that under certain conditions (in particular with intermittent emissions) it is possible to perform an adequate description using the Gaussian model. The dispersion coefficients (σ{sub y} and σ{sub z}), that using the Gaussian model, were obtained from different correlations given in the literature. Also in Chapter 5 is presented the construction of a particular correlation using Lagrange polynomials, which takes information from the Pasquill-Gifford-Turner curves (PGT). This work also contains a state of the art about the coefficients that relate the concentration with the equivalent dose. This topic is discussed in Chapter 6, including a brief description of the biological-compartmental models developed by the ICRP. The software s development was performed using the programming language Python 2.7, for the Windows operating system (the XP version or later). And several tools were integrated using the Tk inter library and graphics using Matplotlib. DERA generates files with .xls extension, an each file contains data tabulated as a function of distance for scattering coefficients and concentration and dose equivalent, both external and internal. It also contains a module to represent iso curves using the mapping tool Google Earth, using files with kml extension, generated with Python. A module that allows the coupling between the data from the meteorological tower and emission registration system was also developed. Such coupling is carried out through a system of folders and files, where emission times are specified, in order to calculate both, external and internal, annual equivalent dose. The 5 modules of the software and the technical description of development is presented in Chapter 7. It is included a methodology for verification and validation of the developed software. In the case of verification, a set of problems proposed in the literature was computed, and was verified the correct integration of the set of coefficients proposed by the EPA and the ICRP. With respect to validation, a graphical analysis between the interpolation developed, and PGT curves was performed. These topics are described in detail in Chapter 8. Finally this work is presented in such a way that serves to guide to the incipient effort to develop computational and portable tools, serving as a prelude to the future integration of more advanced methods of dispersion, or updating the set of coefficients proposed by the ICRP and EPA. (Author)

  6. Determination of the dose equivalent Hp(0.07) in hands of occupationally exposed personnel in the practice of proton emission tomography (PET/CT); Determinacion de la dosis equivalente Hp(0.07) en manos de trabajadores ocupacionalmente expuestos en la practica de Tomografia por Emision de Positrones (PET/CT)

    Energy Technology Data Exchange (ETDEWEB)

    Lea, D. [Servicio de Radiofisica Sanitaria, Unidad de Tecnologia Nuclear, Instituto Venezolano de Investigaciones Cientificas, Ministerio de Ciencia y Tecnologia, Km 11 Carretera Panamerican, Altos del Pipe, Caracas (Venezuela); Ruiz, N.; Esteves, L. [Centro Diagnostico Docente Las Mercedes, Calle Paris cruce con calle Caroni, Edif. CDD, Las Mercedes, Caracas (Venezuela)]. e-mail: dlea@ivic.ve

    2006-07-01

    In Venezuela recently it was implanted the Positron Emission Tomography technique (PET) with the perspective of implanting it at national level. Even when in our country practices it of nuclear medicine it exists from early of 70, there is not experience in the determination of the occupational doses by exposure to the external radiation in hands. By this reason, a concern exists in the workers of the centers of nuclear medicine where it is practiced the Positron Emission Tomography technique. In absence of the TLD dosimetry to measure dose in hands in our country, measurements of the dose equivalent of the workers of the PET national reference center were made, using a detector of hands type diode. It was determined the dose in hands in terms of dose equivalent Hp(0.07) in two work positions, that is: the corresponding to the transfer of the receiving vial of ({sup 18}F) FDG to the shield, quality control and uni doses division. The second work position corresponds the person in charge of administering, via intravenous, the ({sup 18}F) FDG. In this work it realizes the dose equivalent in hands Hp(0.07) measures in each one of the work positions before described by daily production. The informed doses correspond to a total average produced activity of 20.4 GBq (550 mCi). The results of the measurements in terms of dose equivalent in hands Hp(0.07) correspond to 2.1 {+-} 20% mSv in the work position of division and 0.4 {+-} 10% mSv in the position of injection of the radioactive material. At short term this foreseen until 4 productions per week, what means an annual dose equivalent Hp(0.07) in hands of 400 mSv approximately, without taking into account abnormal situations as its are spills of the ({sup 18}F) FDG in the work place. This work is the starting point so that the regulatory authority settles down, in Venezuela, dose restrictions in the PET practices and implant, in the centers of nuclear medicine, an optimization politics of this practice in conformity with the ALARA principle. (Author)

  7. Dosimetric contribution of the organs of the I{sup 123}, I{sup 124} and I{sup 131} bio-kinetics in the dose estimate for euthyroid adults; Contribucion dosimetrica de los organos de la biocinetica de I{sup 123}, I{sup 124} y I{sup 131} en el estimado de dosis para adultos eutiroideos

    Energy Technology Data Exchange (ETDEWEB)

    Vasquez, A. M.; Rojas, A. R.; Castillo, D. C.; Idrogo, C. J.; Flores, U. H., E-mail: marvva@hotmail.com [Universidad Nacional de Trujillo, Av. Juan Pablo II s/n, Ciudad Universitaria, Trujillo (Peru)

    2011-10-15

    Using the formalism MIRD and the representation of Crysty-Eckerman for the thyroid adult, is demonstrated that the dosimetric contributions of source organs of the biokinetics of the radiopharmaceuticals I{sup 123}, I{sup 124} and I{sup 131} (iodine) are not significant in the dose estimate. Therefore, the total absorbed dose by the gland is its auto-dose. Equally, the reported results do not present significant differences to the results found by the Marinelli scheme (auto-dose) for the thyroid represented by a sphere of 20 grams. (Author)

  8. Assessment of beta-emitter radionuclides in biological samples using liquid scintillation counting. Application to the study of internal doses in molecular and cellular biology techniques; Evaluacion en muestras biologicas de radionucleidos emisores beta mediante espectrometria de centelleo en fase liquida. Aplicaciones al estudio de dosis internas en tecnicas de investigacion de biologia molecular y celular

    Energy Technology Data Exchange (ETDEWEB)

    Sierra, I.; Delgado, A.; Navarro, T.; Macias, M. T.

    2007-07-01

    The radioisotopic techniques used in Molecular and Cellular Biology involve external and internal irradiation risk. It is necessary to control the possible internal contamination associated to the development of these techniques. The internal contamination risk can be due to physical and chemical properties of the labelled compounds, aerosols generated during the performance technique. The aim of this work was to estimate the possible intake of specific beta emitters during the technique development and to propose the required criterions to perform Individual Monitoring. The most representative radioisotopic techniques were selected attending their potential risk of internal contamination. Techniques were analysed applying IAEA methodology according to the used activity in each technique. It was necessary to identify the worker groups that would require individual monitoring on the base of their specific risk. Different measurement procedures were applied to study the possible intake in group risk and more than 160 persons were measured by in vitro bioassay. (Author) 96 refs.

  9. Blind method of clustering for the evaluation of the dose received by personnel in two methods of administration of radiopharmaceuticals; Metodo ciego de clusterizacion para la evaluacion de la dosis recibida por el personal en dos metodos de administracion de radioformacos

    Energy Technology Data Exchange (ETDEWEB)

    VerdeVelasco, J. M.; Gonzalez Gonzalez, M.; Montes Fuentes, C.; Verde Velasco, J.; Gonzalez Blanco, F. J.; Ramos Pacho, J. A.

    2013-07-01

    The difficulty for the injection of drugs marked with radioactive isotopes while syringe is located within the lead protector does that in many cases staff do it chooses to use the syringe outside the lead protector, increasing therefore the dose of radiation received. In our service raises the possibility of using a different methodology, channeling a pathway through a catheter, which allows administer, in all cases, with the syringe within the lead guard. We will check if significant differences can be seen both in the dose absorbed by the staff as in the time it takes to perform the administration of the drug using the method proposed compared injection without guard. (Author)

  10. Effect of the dose and route of administration of butylscopolamine on the reduction of the artifacts associated with intestinal peristalsis in abdominal magnetic resonance; Efecto de la dosis y la via de administracion de butilescopolamina en la disminucion de los artefactors asociados al peristaltismo intestinal en la RM abdominal

    Energy Technology Data Exchange (ETDEWEB)

    Dosda, R.; Marti-Bonmati, L. [Hospital Universitario Dr Peset. Valencia. Clinica Quiron. Valencia (Spain); Ronchera-Oms, C. [Hospital San Pablo-CEU. Moncada Valencia (Spain)

    1999-07-01

    To compare the effect of the route of administration (intravenous and oral) and the dose (40 mg and 80 mg) of butylscopolamine, determining its efficacy in reducing the noise associated with gastrointestinal movement in magnetic resonance (MR) images and the incidence and severity of associated adverse reactions. The present prospective, controlled, double-blind study included 80 patients who underwent abdominal MR. All the patients were given oral, high-density barium sulfate and were divided randomly into 4 groups of 20 patients each: a control group and 3 groups treated with 40 mg or 80 mg of oral butylscopolamine or 40 mg of intravenous butylscopolamine. Both the barium and the oral solutions were administered 25 to 30 minutes before the examination. the MR images were obtained with a STIR sequence (1487/100/44), and qualitative analysis of the noise was carried out using regions of interest situated in the background. The gastrointestinal noise was defined both by the mean and the standard deviation of the signal intensity of the air front of an behind the patient. The standard deviation of the air beside the patient was determined to confirm the absence of variations in noise inherent to MR. The adverse reactions to MR after 2 hours (immediate) and one day (late) were recorded. There were no significant differences among the groups with respect to sex, age or time interval between administration of the oral solution and the start of the sequence. The noise inherent to MR was not significantly different from one group to another (Student-Newman-Keuls test, p=0.71). Both the mean and the standard deviation of the intensity of the air situated in anteroposterior phase-encoding direction were significantly lower in the butylscopolamine groups than in the control group (Student-Newman-Keuls test, p=0.008). The most marked reduction was observed after the oral dose of 80 mg, followed by intravenous injection of 40 mg and the oral dose of 40 mg. Adverse reaction were observed in only 4 patients, 2 in the i. v. butylscopolamine group (mild abdominal pain and dry mouth), 1 in the oral 40 mg group (bad taste in mouth) and 1 in the control group (nausea). The combination of a drug to inhibit peristalsis and a negative oral contrast agent significantly reduces the intensity of artifacts in abdominal MR imaging. In view of its efficacy, route of administration and adverse reaction profile, the oral administration of 80 mg of butylscopolamine can be considered a safe and effective option. (Author) 12 refs.

  11. Influencia del tipo de enmienda orgánica, dosis de riego y acolchado de plástico en un cultivo de tomate para industria : dinámica de nutrientes en el sistema suelo-planta, calidad de fruto y producción

    OpenAIRE

    Barba Corbalán, Eva María

    2016-01-01

    El tomate (Lycopersicon esculentum Mill.) es uno de los frutos más ampliamente consumidos, siendo España el segundo productor de tomate de Europa. La calidad de los tomates viene principalmente determinada por la apariencia, la firmeza, el sabor y el valor nutritivo. Después de la cosecha, la maduración del fruto continua, pudiendo provocar una pérdida de calidad, por esta razón es muy importante determinar el momento óptimo del corte del fruto. La gestión de una agricultura sostenible, im...

  12. Evaluation of image quality and dose in thoracic spiral CT examination in patients with pulmonary carcinoma. Preliminary results; Evaluacion de la calidad de imagen y de la dosis en examenes de TC helicoidal de torax en pacientes con carcinoma de pulmon. Resultados preliminares

    Energy Technology Data Exchange (ETDEWEB)

    Moran-Blanco, L. M.; Rodriguez-Gonzalez, R.; Calzado-Cantera, A.; Arenas de Pablo, A.; Baeza-Trujillo, M.; Cuevas-Ibanez, A.; Garcia-Castano, B.; Gomez-Leon, N.; Turrero-Nogues, A.; Moran-Penco, P.

    2002-07-01

    We have applied criteria for CT quality defined in the European Guidelines to a samples of thoracic CT examinations for the indication of pulmonary carcinoma of 5 institutions of the Community of Madrid that have spiral CT equipment. The selected examinations have been evaluated independently by five radiologists to determine the degree of adherence to the quality criteria for image defined in the Guidelines s for examinations of general thorax. Dosimetric measurements carried out in parallel have served to estimate the values of CT (CTDI{sub w}) dose indices, dose-length product (DLP) and effective dose for every patient. The result show a high global adherence to the quality criteria (96%), with averages per institution being between 94% (in two institutions) and 98% (in three institutions). There are 10 of 16 criteria that are adhered to in all examinations of the sample: those which are not adhered to systematically are: two of visualization (1.1 and 1.4), with 92-96% fulfillment, and four of critical reproduction (2.6; 2.8; 2.9 and 2.10), with percentages of adherence between 91% and 96%. The average CTDI{sub w} values per institution are in the interval 12.9-19.1 mGy; those of DLP between 263 and 577 mGy cm and those of effective dose between 4.2 and 9.2 mSv. The DLP-image quality correlation in institutions with the best image quality was null in two of them and direct and moderate in the third. In both institutions with the poorest image: (Author) 20 refs.

  13. Feasibility of the use of PET/CT with {sup 1}8F-colina to increase the dose in traprostaticas lesions in radiotherapy of prostate cancer treatment; Viabilidad del uso de la PET/TC con {sup 1}8F-colina para aumentar la dosis en las lesiones intraprostaticas en tratamientos de radioterapia de cancer de prostata

    Energy Technology Data Exchange (ETDEWEB)

    Garcia Hernandez, T.; Vicedo Gonzalez, A.; Pastor Peidro, J.; Lopez Torrecilla, J.; Rosello Ferrando, J.; Brualla Congalez, L.; Granero Cabanero, D.; Ferrer Rebolleda, J.; Sanchez Jurado, R.

    2013-07-01

    This paper explores the viability of an escalation of doses higher than 80 Gy in intraprostatics lesions, defined by 18FFluorocolina PET/CT, analyzing the variation of the dose in the organs of risk with respect to traditional planning with CT. (Author)

  14. Dosimetric contribution of organs of biokinetics of {sup 99m}Tc and {sup 123}I to estimate radiation doses in thyroids of children of 1 and 5 years; Contribucion dosimetrica de organos de la biocinetica del {sup 99m}Tc y {sup 123}I para estimar dosis en tiroides de ninos de 1 y 5 anos

    Energy Technology Data Exchange (ETDEWEB)

    Vasquez, M.V.; Castillo, C.E.; Abanto, D.M.; Rocha, D.; Garcia, W.H.; Marin, K., E-mail: marvva@hotmail.com [Universidad Nacional de Trujillo (UNT), Trujillo (Peru); Quispe, R. [Centro de Ciencias Aplicadas y Desarrollo Tecnologico, UNAM, Mexico (Mexico)

    2015-07-01

    The absorbed doses by thyroids during uptake studies through biokinetics of radiopharmaceuticals containing {sup 123}I (iodine) or {sup 99m}Tc (pertechnetate) are estimated. Using the MIRD scheme and the representation of Cristy-Eckerman for thyroids in children of 1 and 5 years, the objective of the study was to determine whether the dosimetric biokinetic contributions of the organs of {sup 123}I (iodide) and {sup 99m}Tc (pertechnetate) biokinetic are significant in the estimated of the absorbed dose for thyroid uptake studies.

  15. Characterization of Dose in a TC of 64-Detectors used in pediatrics. Evaluation of the effects of the Over beaming and Over ranging; Caracterizacion de dosis en un TC de 64 detectores utilizado en pediatria. Evaluacion de los efectos del Overbeaming y Overranging

    Energy Technology Data Exchange (ETDEWEB)

    Garcia Castanon, P.; Roch Gonzalez, M.; Rodriguez Martin, G.; Espana Lopez, M. L.; Giner Sala, M.

    2013-07-01

    The objective of this study is to evaluate the contribution of effects over beaming and over ranging dose received by the patient in a TC multislice with 64 detectors, installed at a children's hospital, for the different acquisition modes available, in order to assess the adequacy of the protocols pre-set for Pediatrics and more accurately assess the received dose. (Author)

  16. Series de tiempo de asociación entre el uso de ertapenem dosis diaria definida por 100 días de estancia y la resistencia a carbapenemicos en enterobacterias en el Hospital Universitario Clínica San Rafael entre 2007 y 2009

    OpenAIRE

    Narváez Mejía, Álvaro Javier

    2011-01-01

    La resistencia a carbapenemes es un evento, que en los últimos años se ha aumentado en la familia de las Enterobacteriaceae. Debido a que el uso de antimicrobianos lleva indefectiblemente al desarrollo de resistencia, el estudio de las relaciones entre el consumo de antibióticos y la resistencia bacteriana despierta desde hace años un gran interés, la vigilancia de este evento provee la información sobre la magnitud y la tendencia de la resistencia de los diferentes microorganismos y esta mon...

  17. Measurement of extrapolation curves for the secondary pattern of beta radiation Nr. 86 calibrated in rapidity of absorbed dose for tissue equivalent by the Physikalisch Technische Bundesanstalt; Medicion de curvas de extrapolacion para el patron secundario de radiacion beta Nr. 86 calibrado en rapidez de dosis absorbida para tejido equivalente por el Physikalisch Technische Bundesanstalt

    Energy Technology Data Exchange (ETDEWEB)

    Alvarez R, J.T

    1988-10-15

    The following report has as objective to present the obtained results of measuring - with a camera of extrapolation of variable electrodes (CE) - the dose speed absorbed in equivalent fabric given by the group of sources of the secondary pattern of radiation Beta Nr. 86, (PSB), and to compare this results with those presented by the calibration certificates that accompany the PSB extended by the primary laboratory Physikalisch Technische Bundesanstalt, (PTB), of the R.F.A. as well as the uncertainties associated to the measure process. (Author)

  18. Radiological protection on interstitial brachytherapy and dose determination and exposure rate of an Ir-192 source through the MCNP-4B; Proteccion radiologica en braquiterapia intersticial y determinacion de la dosis y tasa de exposicion de una fuente de Ir-192 mediante el MCNP-4B

    Energy Technology Data Exchange (ETDEWEB)

    Morales L, M.E. [INEN, Av. Angamos Este 2520- Surquillo, Lima (Peru)

    2006-07-01

    The present work was carried out in the Neurological Sciences Institute having as objective to determine the dose and the rate of exhibition of the sources of Iridium 192, Iodine 125 and Palladium 103; which are used to carry out implant in the Interstitial Brachytherapy according to the TG43. For it we carry out a theoretical calculation, its are defined in the enter file: the geometry, materials of the problem and the radiation source, etc; in the MCNP-4B Monte Carlo code, considering a punctual source and for the dose determination we simulate thermoluminescent dosemeters (TLD): at 5 cm, 50 cm, 100 cm and 200 cm of the source. Our purpose is to analyze the radioprotection measures that should take into account in this Institute in which are carried out brain biopsies using a Micro mar stereotactic mark, and in a near future with the collaboration of a doctor and a cuban physique seeks to be carried out the Interstitial Brachytherapy technique with sources of Ir-192 for patient with tumors like glioblastoma, astrocytoma, etc. (Author)

  19. Evaluation of a pyrex glass shield for the dose reduction in extremities to manipulate a {sup 90} Sr- {sup 90} Y generator; Evaluacion de un blindaje de vidrio pyrex para la reduccion de las dosis en extremidades al manipular un generador de {sup 90} Sr- {sup 90} Y

    Energy Technology Data Exchange (ETDEWEB)

    Ayra P, F.E.; Xiques C, A.; Torres B, M.B. [Centro de Isotopos, Carretera La Rada, Km 3 1/2, Guanabacoa, La Habana (Cuba)]. e-mail: feayra@centis.edu.cu

    2006-07-01

    The production of Y-90 of high activity it specifies (free of payee) for their use in radioimmunotherapy uses the Strontium 90 as isotope source. Depending on the method employee for the separation of both isotopes several types of generators are described in different bibliographies. The column generator used in the facilities of the Center of Isotopes requires of a frequent manipulation causing significant dose in the skin of the extremities due to the exhibition to the radiation beta of high energy. The properties of the shieldings for this radiation type have been well studied Y they consist in several publications. To be in correspondence with requirements of radiological protection in the Cuban legislation, the column was covered with a tube of glass pyrex of 5 mm of thickness and it was monitored the exposure with an ionization chamber. At the own time, the shielding using the Monte Carlo method was evaluated. It was used the MCNP 4C code to simulate the absorption of the beta particles generated in the process of disintegration of the Sr-90 and Y-90 in the glass shielding. The column generator and the fluence of beta particles were modeled in different points inside the shielding to determine if the experimentally measured values correspond to electrons that were not absorbed or to the weak stopping radiation generated in the glass due to the deceleration of these particles. A cylinder of 4 mm of diameter simulates the source (it dilutes) and a tube of walls of 6 mm of thickness simulates the shielding more the wall of the column around the generator. This it was divided in cells of 1 mm of thickness and the energy deposited in them was evaluated. The results show that all the electrons generated in the source are absorbed in the shielding and the exposure rates decrease in more of 78 times using the 5 mm of pyrex glass. The doses in extremities to the operators of the generator don't surpass the 70 mSv by year that is the dose restriction imposed in the Center of Isotopes. This is of special importance keeping in mind a future escalate in the production of Y-90 in our facilities. (Author)

  20. Evaluation of Mird and Marinelli formalisms in the radiation dosimetry for thyroid of adults and children using {sup 131I} (radioiodine); Evaluacion de las dosimetrias Mird y de Marinelli en el estimado de dosis de radiacion para tiroides de adultos y ninos cuando se usa {sup 131}I (yoduro)

    Energy Technology Data Exchange (ETDEWEB)

    Vasquez, A.M.; Rocha, J.J.; Castillo, D.C.; Gomez, M.A.; Mendoza, A.A.; Rabanal, M.J.; Cruz, S.J. [Universidad Nacional de Trujillo (UNT-UCV), Trujillo (Peru). Grupo de Fisica Medica

    2013-11-01

    Using MIRD formalism and Cristy-Eckerman representation for the thyroid adults, children of 15, 10, 5, 1 year old and newborn it is shown that the total dose absorbed by the gland due to {sup 131}I(iodine) is its self-dose. Their results are not significantly different from those reported by the formalism MARINELLI (self-dose), which uses a sphere as glandular representation. Consequently, the kinetic model to the gland is a single compartment and the thyroid can be represented as a sphere.