WorldWideScience

Sample records for admin restriction faq

  1. Infertility FAQ's

    Science.gov (United States)

    ... Links Infertility & STDs Infertility FastStats Assisted Reproductive Technology (ART) Reproductive Health For The Media 9:00 a.m. - 6:00 p.m. (404) 639-3286 After hours (404) 639-2888 Contact Media Infertility FAQs Recommend on Facebook Tweet Share Compartir On this Page What is ...

  2. Hepatitis A FAQs

    Science.gov (United States)

    ... of Viral Hepatitis Contact Us Quick Links to Hepatitis ... A | B | C | D | E Viral Hepatitis Home ... Outbreaks State and Local Partners & Grantees Resource Center Hepatitis A FAQs for the Public Recommend on Facebook ...

  3. Heart Attack Recovery FAQs

    Science.gov (United States)

    ... Pressure High Blood Pressure Tools & Resources Stroke More Heart Attack Recovery FAQs Updated:Aug 24,2016 Most people ... recovery. View an animation of a heart attack . Heart Attack Recovery Questions and Answers What treatments will I ...

  4. Turner Syndrome: Other FAQs

    Science.gov (United States)

    ... NICHD Research Information Clinical Trials Resources and Publications Turner Syndrome: Other FAQs Skip sharing on social media links ... been diagnosed with Turner syndrome. Now what? Is Turner syndrome inherited? Turner syndrome is usually not inherited, but ...

  5. Hepatitis C FAQs

    Science.gov (United States)

    ... State and Local Partners & Grantees Resource Center Hepatitis C FAQs for the Public Recommend on Facebook Tweet ... URL - Redirecting ... Quick Links to Hepatitis ... A | B | C | D | E Viral Hepatitis Home Statistics & Surveillance Populations & ...

  6. Hepatitis B FAQs

    Science.gov (United States)

    ... State and Local Partners & Grantees Resource Center Hepatitis B FAQs for the Public Recommend on Facebook Tweet ... date URL - redirecting ... Quick Links to Hepatitis ... A | B | C | D | E Viral Hepatitis Home Statistics & Surveillance ...

  7. Drinking Water FAQ

    Science.gov (United States)

    ... your well Who should test your well Drinking Water FAQ Frequently Asked Questions General Where does my ... CDC's Private Wells page. Top of Page Public Water Systems What type of health issues can be ...

  8. FAQ: Child Sexual Exploitation

    Science.gov (United States)

    ... Support FAQ: Child Sexual Exploitation What is child pornography? Federal law (18 U.S.C. §2256(8)) defines ... person under the age of 18. Is child pornography a crime? It is a federal crime to ...

  9. Fragile X Syndrome: Other FAQs

    Science.gov (United States)

    ... NICHD Research Information Clinical Trials Resources and Publications Fragile X Syndrome: Other FAQs Skip sharing on social media links ... Are there specific disorders or conditions associated with Fragile X syndrome? Among the other conditions associated with Fragile X ...

  10. Modernising the CERN Admin e-guide

    CERN Multimedia

    DG-RPC-PA (section des processus administratifs)

    2014-01-01

    In just a few years, the CERN Admin e-guide has become the essential guide for CERN's administrative procedures, intended not just for administrative services but for all members of the personnel of CERN. The guide is edited by the Administrative Process Section (DG-RPC-PA) and allows users to look up administrative procedures and forms relating to the application of the Staff Rules and Regulations easily in both French and English. Site visit statistics show that 5000 people on average consult the Admin e-guide each month. The most consulted procedures are those relating to green licence plates, taxes, Swiss and French cards and leave. The site has just been moved over to Drupal, which will make it easier to update the information provided and will improve content management. This system change meant migrating 220 procedures and more than 500 frequently asked questions. The structure has been revised for clarity, but the principles that made the guide so successful have not changed, namely the e...

  11. Lyme Disease Frequently Asked Questions (FAQ)

    Science.gov (United States)

    ... Lyme disease FAQ Health care providers Educational materials Lyme Disease Frequently Asked Questions (FAQ) Language: English Español ( ... been bitten by a tick. Do I have Lyme disease? If you have not done so already, ...

  12. FAQ on Tattoos and Breastfeeding

    Science.gov (United States)

    ... Добро пожаловать ברוכים הבאים HOŞ GELDİNİZ FAQ on Tattoos and Breastfeeding Breastfeeding and tattooing are enjoying resurgence ... and Breastfeeding. Is it safe to get a tattoo while breastfeeding? Tattoos are created by injecting ink ...

  13. MedlinePlus FAQ: Search Cloud

    Science.gov (United States)

    ... faq/searchcloud.html Question: How does the search cloud work? To use the sharing features on this page, please enable JavaScript. Answer: The search cloud displays the top 100 search terms typed into ...

  14. Frequently Asked Questions (FAQ) about Extreme Heat

    Science.gov (United States)

    ... of Emergencies Frequently Asked Questions (FAQ) About Extreme Heat Recommend on Facebook Tweet Share Compartir What happens ... body as a result of exposure to extreme heat? People suffer heat-related illness when the body’s ...

  15. Total Petroleum Hydrocarbons (TPH): ToxFAQs

    Science.gov (United States)

    ... a state: This map displays locations where Total Petroleum Hydrocarbons (TPH) is known to be present. On ... I get more information? ToxFAQs TM for Total Petroleum Hydrocarbons (TPH) ( Hidrocarburos Totales de Petróleo (TPH) ) August ...

  16. Scabies: Workplace Frequently Asked Questions (FAQs)

    Science.gov (United States)

    ... CDC.gov . Parasites - Scabies Parasites Home Share Compartir Workplace Frequently Asked Questions (FAQs) On This Page If ... local health department. We would like to create workplace guidelines in case an employee is diagnosed with ...

  17. Launch of the new CERN Admin e-guide

    CERN Multimedia

    Laëtitia Pedroso

    2010-01-01

    The CERN Admin e-guide is a new guide to the Organization's administrative procedures, which has been drawn up for the benefit of members of the personnel and the various administrative services alike and replaces the old "Administrative Procedures Manual". All the different procedures currently available on separate department sites will henceforth be accessible at a single website.   Home page of the new CERN Admin e-guide. The goal of creating a compendium of CERN's administrative procedures, available at a single website and accessible with a simple click of the mouse, has now been realised.  "It had become difficult to know where to find the relevant up-to-date information on administrative procedures", says Yaël Grange-Lavigne of the HR-SPS-OP Section (Organisation and Procedures), coordinator of the working group that compiled the e-guide. The team, which comprised members of the HR Department, observers from other department...

  18. Introducción a phpMyAdmin, ejercicio

    OpenAIRE

    Suárez Cueto, Armando

    2012-01-01

    El propósito del siguiente ejercicio es replicar, más o menos, la base de datos utilizada en los videos de introducción a phpMyAdmin y comprobar que eres capaz de generar una base de datos y unas cuantas tablas relacionadas entre sí. La solución la tienes al final de este documento pero, claro, mejor si lo intentas por ti mismo primero. Recurso para el MOOC "Introducción al Desarrollo Web", http://idesweb.es BDgite (GITE-11014-UA), departamento de Lenguajes y Sistemas Informáticos, Uni...

  19. FAQs about Spinal Cord Injury (SCI)

    Science.gov (United States)

    ... of Care? Emergency Medical Services Hospital (Acute) Care Rehabilitation More FAQs about Spinal Cord Injury (SCI) If you or a loved one is ... spinal cord injury? What recovery is expected following spinal cord injury? Where is the ... on Disability, Independent Living, and Rehabilitation Research (NIDILRR grant number 90SI5005). NIDILRR is a ...

  20. FAQs about practising the amateur arts

    NARCIS (Netherlands)

    Andries van den Broek

    2010-01-01

    Original title: FAQs over kunstbeoefening in de vrije tijd Singing, playing an instrument, painting, sculpting, amateur dramatics, making films, writing a blog or a song…: almost half the Dutch population are engaged in artistic activity occasionally or even frequently. They give expression to this

  1. Improving Windows desktop security - the 'Non-Admin' Project

    CERN Multimedia

    NICE Team

    2005-01-01

    From 16 January 2006, Windows XP NICE installations (both new computers installed and old computers re-installed) will no longer grant administrative privileges by default to the main user or to the person responsible for the computer. Administrative privileges allow the user to perform administrative actions on the computer, such as installing new applications or changing system settings. Until now, these privileges have been enforced each time machines are rebooted, but this creates a risk of compromising the computer every time a code from an unknown source (e.g. e-mail attachments or web browsing) is executed. So that users can continue to install software and change system settings on their computers, a shortcut called 'NiceAdmin' in the Start | Programmes menu will offer a means of performing certain tasks requiring administrative privileges, but only on demand. Users with valid reasons to be a permanent administrator for their machine will still have this option. However, users wishing to benefit fr...

  2. Salmonella: Dry Pet Foods and Pet Treats (FAQ)

    Science.gov (United States)

    ... Guides Reports Salmonella: Dry Pet Foods and Pet Treats (FAQ) Originally posted August 9, 2010; Updated August ... as a result of the outbreak. “Natural” pet treats , such as pig ears and dehydrated/dried beef ...

  3. Introducción a phpMyAdmin (3/4)

    OpenAIRE

    Suárez Cueto, Armando

    2012-01-01

    Curso "Introducción al desarrollo web": inserción de datos, creación de una relación muchos a muchos (N:N), claves ajenas, integridad referencial, diseñador de phpMyAdmin. Más información: http://idesweb.es

  4. MedlinePlus FAQ: Can you tell me how to cite MedlinePlus pages?

    Science.gov (United States)

    ... Here: Home → FAQs → Question URL of this page: https://medlineplus.gov/faq/citation.html Question: Can you ... Aug 12; cited 2005 Aug 11]. Available from: https://medlineplus.gov/. Health Topic page Begin by citing ...

  5. Introducción a phpMyAdmin (2/4)

    OpenAIRE

    Suárez Cueto, Armando

    2012-01-01

    Curso "Introducción al desarrollo web": phpMyAdmin, creación de tablas, tipos de datos, creación de índices, motores de MySQL (INNODB, MyISAM, MEMORY), inserción de datos, seguimiento de una tabla (historial), exportar una tabla (backup). Más información: http://idesweb.es

  6. Mastering phpMyAdmin 34 for Effective MySQL Management

    CERN Document Server

    Delisle, Marc

    2012-01-01

    This is a step-by-step instructional guide to get you started easily with phpMyAdmin and teach you to manage and perform database functions on your database. You will first be introduced to the interface and then build basic tables and perform both simple and advanced functions on the created database. The book progresses gradually and you will follow it best by reading it sequentially. If you are a developer, system administrator, or web designer who wants to manage MySQL databases and tables efficiently, then this book is for you. This book assumes that you are already wellacquainted with My

  7. Introducción a phpMyAdmin (1/4)

    OpenAIRE

    Suárez Cueto, Armando

    2012-01-01

    Curso "Introducción al desarrollo web": explicación del escenario de aprendizaje, repaso de los conceptos básicos de las bases de datos relacionales (clave primaria, clave ajena, relación), repaso del lenguaje de consulta y de manipulación SQL (select, insert, delete, update), presentación del interfaz y del área de trabajo de phpMyAdmin, creación de un usuario de prueba, privilegios (permisos) de los usuarios. Más información: http://idesweb.es

  8. Introducción a phpMyAdmin (parte 0 o resumen)

    OpenAIRE

    Suárez Cueto, Armando

    2012-01-01

    Curso "Introducción al desarrollo web": este vídeo realiza una doble función, sirve como introducción al resto de vídeos, pero también sirve como resumen, por lo que se puede ver tanto al principio como al final. En este vídeo se resume: - Objetivo de los vídeos, introducción a phpMyAdmin. - Parte 1: conceptos generales de bases de datos, creación de usuarios y privilegios. - Parte 2: creación de tablas, tipos de datos, motores de almacenamiento, inserción de filas, exportación (estructura y ...

  9. Semi-Automatically Extracting FAQs to Improve Accessibility of Software Development Knowledge

    CERN Document Server

    Henß, Stefan; Mezini, Mira

    2012-01-01

    Frequently asked questions (FAQs) are a popular way to document software development knowledge. As creating such documents is expensive, this paper presents an approach for automatically extracting FAQs from sources of software development discussion, such as mailing lists and Internet forums, by combining techniques of text mining and natural language processing. We apply the approach to popular mailing lists and carry out a survey among software developers to show that it is able to extract high-quality FAQs that may be further improved by experts.

  10. Restrictive cardiomyopathy

    Science.gov (United States)

    Cardiomyopathy - restrictive; Infiltrative cardiomyopathy ... In a case of restrictive cardiomyopathy, the heart muscle is normal size or slightly enlarged. Most of the time, it also pumps normally. However, it does not ...

  11. A FAQ-Based e-Learning Environment to Support Japanese Language Learning

    Science.gov (United States)

    Liu, Yuqin; Yin, Chengjiu; Ogata, Hiroaki; Qiao, Guojun; Yano, Yoneo

    2011-01-01

    In traditional classes, having many questions from learners is important because these questions indicate difficult points for learners and for teachers. This paper proposes a FAQ-based e-Learning environment to support Japanese language learning that focuses on learner questions. This knowledge sharing system enables learners to interact and…

  12. MedlinePlus FAQ: Can I play videos on my phone or tablet?

    Science.gov (United States)

    ... gov/faq/mobilevideo.html Question: Can I play videos on my phone or tablet? To use the ... this page, please enable JavaScript. Answer: MedlinePlus has video content in different formats. MedlinePlus also links to ...

  13. Restricted Airspace

    Data.gov (United States)

    Federal Laboratory Consortium — Redstone Technical Test Center has restricted airspace up to 30,000 feet ASL. Airspace encompasses R-2104 (Redstone). Airspace is used extensively for airborne/UAV...

  14. Admin on the Fly

    Science.gov (United States)

    Raths, David

    2009-01-01

    Students at Tompkins Cortland Community College (commonly known as TC3) in upstate New York can use mobile phones to check their grades and course schedules, sign up for text alerts about class cancellations, and view a campus weather cam. They can even view their debit card account balances--all courtesy of the TC3 Mobile portal. The students at…

  15. Xgrid admin guide

    Energy Technology Data Exchange (ETDEWEB)

    Strauss, Charlie E M [Los Alamos National Laboratory

    2010-01-01

    Xgrid, with a capital-X is the name for Apple's grid computing system. With a lower case x, xgrid is the name of the command line utility that clients can use, among other ways, to submit jobs to a controller. An Xgrid divides into three logical components: Agent, Controller and Client. Client computers submit jobs (a set of tasks) they want run to a Controller computer. The Controller queues the Client jobs and distributes tasks to Agent computers. Agent computers run the tasks and report their output and status back to the controller where it is stored until deleted by the Client. The Clients can asynchronously query the controller about the status of a job and the results. Any OSX computer can be any of these. A single mac can be more than one: it's possible to be Agent, Controller and Client at the same time. There is one Controller per Grid. Clients can submit jobs to Controllers of different grids. Agents can work for more than one grid. Xgrid's setup has a pleasantly small palette of choices. The first two decisions to make are the kind of authentication & authorization to use and if a shared file system is needed. A shared file system that all the agents can access can be very beneficial for many computing problems, but it is not appropriate for every network.

  16. Sunscreens FAQs

    Science.gov (United States)

    ... resources Meet our partners Español Donate Diseases and treatments Acne and rosacea Bumps and growths Color problems Contagious skin diseases Cosmetic treatments Dry / sweaty skin Eczema / dermatitis Hair and scalp ...

  17. Caregiver FAQ

    Science.gov (United States)

    ... sleep disorders. It is also important to review sleep hygiene such as use of alcohol, caffeine, chocolate or other substances late in the day. Many foods and over the counter medications can have effects on sleep. If excessive daytime sleepiness is a severe problem, ...

  18. Leishmaniasis FAQs

    Science.gov (United States)

    ... have become infected in various countries, such as Iraq and Afghanistan Back To Top Is leishmaniasis found ... source: Global Health - Division of Parasitic Diseases and Malaria Notice: Linking to a non-federal site does ...

  19. Nástroj pro analýzu uživatelských dat získaných z instalací AVG Admin Konzole

    OpenAIRE

    Heroutová, Tereza

    2012-01-01

    Tento dokument se zabývá návrhem a implementací nástroje, který umožňuje vyhodnocování a vizualizaci statistických dat sesbíraných od uživatelů aplikace AVG Admin Konzole. V dokumentu jsou popsána statistická data s jejich lokalizacemi a také uložení všech těchto dat v databázi. Aplikace byla otestována na reálných datech a na základě analýzy výsledků jsou navržena možná vylepšení. This document describes the design and implementation of a tool which allows for evaluation and visualisation...

  20. 基于VSM和LDA模型的FAQ问答系统%FAQ Answering System Based on VSM and LDA Model

    Institute of Scientific and Technical Information of China (English)

    郑诚; 刘娇丽; 项珑

    2014-01-01

    传统的搜索引擎返回的数据太过庞大,很多情况下用户不能快速地找到自己要的答案。在这种情况下,文中引入FAQ系统。 FAQ中如何找到最佳匹配答案,是文中的研究重点。改进了传统的VSM模型,使得它能更好地体现问题中词的权重。重点引入了LDA模型,并用计算机故障领域内的文档资料对它进行训练,得到主题-词的概率分布。通过主题-词中词的概率分布,计算词与词的相关度,提出通过词与词间相关度计算句子与句子间相似度的算法。对两个算法进行综合,得到最终的相似度算法。文中对FAQ进行整理,得到了FAQ问答系统的雏形。通过实验分析,说明相似度算法有很好的效果。%The data returned by the traditional search engine is too large,users cannot quickly find the answer they want sometimes. In this case,introduce FAQ system. How to find the best match in the FAQ system is the focus. An improved VSM model is presented in this pa-per. This new model is used in order to reflect the weight of the terms in question better. LDA,which was trained with documentation within the domain of computer malfunction generates a probability distribution of topic-term by which the relevance between words is calculated. Then the algorithm of calculating similarity between sentences by calculating relevance between words was presented. Com-bined with the above two algorithm,get the final similarity algorithm. FAQ is collected and rudiment of FAQ answering system is imple-mented in this paper. The algorithm used is proved well by the experiments.

  1. Estimating Trade Restrictiveness Indices

    OpenAIRE

    Kee, Hiau Looi; Nicita, Alessandro; Olarreaga, Marcelo

    2009-01-01

    Studies of the impact of trade restrictiveness on growth, poverty, or unemployment are frequent in the academic literature. Few authors, however, provide a precise definition of what they mean by trade restrictiveness. When they do, the definition is unlikely to have tight links with trade theory. The objective of this article is to fill this gap by providing for 78 developing and developed countries clearly defined indicators of trade restrictiveness that are well grounded in trade theory. R...

  2. Synthesis of Key Points from the OSEP Early Childhood Transition FAQ (SPP/APR Indicators C-8, B-11 and B-12)

    Science.gov (United States)

    Diefendorf, M.; Henson, J.; Lucas, A.; Whaley, K.

    2010-01-01

    This document is a synthesis of the key points provided in the Office of Special Education Programs (OSEP) Early Childhood Transition FAQs: SPP/APR indicators C-8 and B-12 released on December 1, 2009. It was developed to assist states with the implementation of effective transition policies and practices. The following is included: (1) Transition…

  3. Restrictions and Proportionality

    DEFF Research Database (Denmark)

    Werlauff, Erik

    2009-01-01

    The article discusses three central aspects of the freedoms under European Community law, namely 1) the prohibition against restrictions as an important extension of the prohibition against discrimination, 2) a prohibition against exit restrictions which is just as important as the prohibition...... against host country restrictions, but which is often not recognised to the same extent by national law, and 3) the importance of also identifying and recognising an exit restriction, so that it is possible to achieve the required test of appropriateness and proportionality in relation to the rule...

  4. Restrictions of stable bundles

    CERN Document Server

    Balaji, V

    2011-01-01

    The Mehta-Ramanathan theorem ensures that the restriction of a stable vector bundle to a sufficiently high degree complete intersection curve is again stable. We improve the bounds for the "sufficiently high degree" and propose a possibly optimal conjecture.

  5. Neuroaesthetics: range and restrictions.

    Science.gov (United States)

    Chatterjee, Anjan

    2013-04-01

    Bullot & Reber (B&R) should be commended for highlighting tensions between scientific aesthetics and art history. The question of how each tradition can learn from the other is timely. While I am sympathetic to their views, their diagnosis of the problem appears exaggerated and their solution partial. They underestimate the reach of scientific aesthetics while failing to identify its inherent restrictions. PMID:23507092

  6. Training Restricted Boltzmann Machines

    DEFF Research Database (Denmark)

    Fischer, Asja

    Restricted Boltzmann machines (RBMs) are probabilistic graphical models that can also be interpreted as stochastic neural networks. Training RBMs is known to be challenging. Computing the likelihood of the model parameters or its gradient is in general computationally intensive. Thus, training...

  7. Calorie restriction and stroke

    Directory of Open Access Journals (Sweden)

    Manzanero Silvia

    2011-09-01

    Full Text Available Abstract Stroke, a major cause of disability and mortality in the elderly, occurs when a cerebral blood vessel is occluded or ruptured, resulting in ischemic damage and death of brain cells. The injury mechanism involves metabolic and oxidative stress, excitotoxicity, apoptosis and inflammatory processes, including activation of glial cells and infiltration of leukocytes. In animal models, dietary energy restriction, by daily calorie reduction (CR or intermittent fasting (IF, extends lifespan and decreases the development of age-related diseases. Dietary energy restriction may also benefit neurons, as suggested by experimental evidence showing that CR and IF protect neurons against degeneration in animal models. Recent findings by our group and others suggest the possibility that dietary energy restriction may protect against stroke induced brain injury, in part by inducing the expression of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF and basic fibroblast growth factor (bFGF; protein chaperones, including heat shock protein 70 (Hsp70 and glucose regulated protein 78 (GRP78; antioxidant enzymes, such as superoxide dismutases (SOD and heme oxygenase-1 (HO-1, silent information regulator T1 (SIRT1, uncoupling proteins and anti-inflammatory cytokines. This article discusses the protective mechanisms activated by dietary energy restriction in ischemic stroke.

  8. Bilinear Fourier restriction theorems

    CERN Document Server

    Demeter, Ciprian

    2012-01-01

    We provide a general scheme for proving $L^p$ estimates for certain bilinear Fourier restrictions outside the locally $L^2$ setting. As an application, we show how such estimates follow for the lacunary polygon. In contrast with prior approaches, our argument avoids any use of the Rubio de Francia Littlewood--Paley inequality.

  9. Restriction of Helmholtz Model

    Directory of Open Access Journals (Sweden)

    V.M. Polunin

    2014-07-01

    Full Text Available The results of the experimental studies of physical mechanisms of energy dissipation in the oscillating system in which air cavity held by the forces of magnetic levitation is used as the elastic element, and magnetic fluid prepared on the basis of dispersing media with different viscosity level is used as the inertial element are considered in the article. Based on the obtained results the conclusion on the restriction of the applicability of Helmholtz equation, caused by boundary effects is made.

  10. Late gestational nutrient restriction

    DEFF Research Database (Denmark)

    Tygesen, Malin Plumhoff; Nielsen, Mette Olaf; Nørgaard, Peder;

    2008-01-01

    We investigated the effect of 50% nutrient restriction during the last 6 weeks of gestation on twin-pregnant ewes' plasma glucose, non-esterified fatty acid, ß-hydroxybutyrate, insulin, IGF-1 and leptin concentrations and the effects on lamb birth weight and ewes' lactation performance. Plasma...... changes in feed intake and energy balance. It is concluded that severely reduced nutrient availability in late gestation affects fetal growth in utero and has a prolonged negative effect on lactation performance....

  11. License restrictions at Barnwell

    Energy Technology Data Exchange (ETDEWEB)

    Autry, V.R. [S.C. Dept. of Health and Environmental Control, Columbia, SC (United States). Bureau of Radiological Health

    1991-12-31

    The State of South Carolina was delegated the authority by the US Nuclear Regulatory Commission to regulate the receipt, possession, use and disposal of radioactive material as an Agreement State. Since 1970, the state has been the principal regulatory authority for the Barnwell Low-Level Waste Disposal Facility operated by Chem-Nuclear Systems, Inc. The radioactive material license issued authorizing the receipt and disposal of low-level waste contains numerous restrictions to ensure environmental protection and compliance with shallow land disposal performance criteria. Low-level waste has evolved from minimally contaminated items to complex waste streams containing high concentrations of radionuclides and processing chemicals which necessitated these restrictions. Additionally, some waste with their specific radionuclides and concentration levels, many classified as low-level radioactive waste, are not appropriate for shallow land disposal unless additional precautions are taken. This paper will represent a number of these restrictions, the rationale for them, and how they are being dealt with at the Barnwell disposal facility.

  12. Very strict selectional restrictions

    CERN Document Server

    Laporte, Eric; Dias, Maria Carmelita P

    2007-01-01

    We discuss the characteristics and behaviour of two parallel classes of verbs in two Romance languages, French and Portuguese. Examples of these verbs are Port. abater [gado] and Fr. abattre [b\\'etail], both meaning "slaughter [cattle]". In both languages, the definition of the class of verbs includes several features: - They have only one essential complement, which is a direct object. - The nominal distribution of the complement is very limited, i.e., few nouns can be selected as head nouns of the complement. However, this selection is not restricted to a single noun, as would be the case for verbal idioms such as Fr. monter la garde "mount guard". - We excluded from the class constructions which are reductions of more complex constructions, e.g. Port. afinar [instrumento] com "tune [instrument] with".

  13. Restricting retrotransposons: a review.

    Science.gov (United States)

    Goodier, John L

    2016-01-01

    Retrotransposons have generated about 40 % of the human genome. This review examines the strategies the cell has evolved to coexist with these genomic "parasites", focussing on the non-long terminal repeat retrotransposons of humans and mice. Some of the restriction factors for retrotransposition, including the APOBECs, MOV10, RNASEL, SAMHD1, TREX1, and ZAP, also limit replication of retroviruses, including HIV, and are part of the intrinsic immune system of the cell. Many of these proteins act in the cytoplasm to degrade retroelement RNA or inhibit its translation. Some factors act in the nucleus and involve DNA repair enzymes or epigenetic processes of DNA methylation and histone modification. RISC and piRNA pathway proteins protect the germline. Retrotransposon control is relaxed in some cell types, such as neurons in the brain, stem cells, and in certain types of disease and cancer, with implications for human health and disease. This review also considers potential pitfalls in interpreting retrotransposon-related data, as well as issues to consider for future research. PMID:27525044

  14. Property Rights, Restrictions and Responsibilities

    DEFF Research Database (Denmark)

    Enemark, Stig

    Land Administration Systems are the basis for conceptualizing rights, restrictions and responsibilities related to people, policies and places. Property rights are normally concerned with ownership and tenure whereas restrictions usually control use and activities on land. Responsibilities relate...... more to a social, ethical commitment or attitude to environmental sustainability and good husbandry. This paper provides an overall understanding of the concept of land administration systems for dealing with rights, restrictions and responsibilities in future spatially enabled government. Finally...

  15. How harmful are adaptation restrictions

    OpenAIRE

    Bruin, de, B.; Dellink, R.B.

    2009-01-01

    The dominant assumption in economic models of climate policy remains that adaptation will be implemented in an optimal manner. There are, however, several reasons why optimal levels of adaptation may not be attainable. This paper investigates the effects of suboptimal levels of adaptation, i.e. adaptation restrictions, on the composition and level of climate change costs and on welfare. Several adaptation restrictions are identified and then simulated in a revised DICE model, extended with ad...

  16. Remarks on restricted Nevanlinna transforms

    CERN Document Server

    Jankowski, Lech

    2010-01-01

    The Nevanlinna transform K(z), of a measure and a real constant, plays an important role in the complex analysis and more recently in the free probability theory (boolean convolution). It is shown that its restriction k(it) (the restricted Nevanlinna transform) to the imaginary axis can be expressed as the Laplace transform of the Fourier transform (characteristic function) of the corresponding measure. Finally, a relation between the Voiculescu and the boolean convolution is indicated.

  17. ToxFAQs

    Science.gov (United States)

    ... hidrógeno y flúor Formaldehyde | Formaldehido Fuel Oils / Kerosene | Aceites combustibles G Gasoline, Automotive | Gasolina de automóvil Glutaraldehyde * ... Uranium * Other Languages... Used Mineral-based Crankcase Oil | Aceite Usado de Cárter V Vanadium * Other Languages... Vinyl ...

  18. I-94 Automation FAQs

    Data.gov (United States)

    Department of Homeland Security — In order to increase efficiency, reduce operating costs and streamline the admissions process, U.S. Customs and Border Protection has automated Form I-94 at air and...

  19. Animal Drug Safety FAQs

    Science.gov (United States)

    ... Vaccines, Blood & Biologics Animal & Veterinary Cosmetics Tobacco Products Animal & Veterinary Home Animal & Veterinary Safety & Health Frequently Asked Questions Animal Drug Safety Frequently Asked Questions Share Tweet Linkedin ...

  20. FAQs about Clostridium Difficile

    Science.gov (United States)

    ... on contaminated equipment and on the hands of doctors, nurses, other healthcare providers and visitors. Can C. diff ... C. diff infections? To prevent C. diff. infections, doctors, nurses, and other healthcare providers: • Clean their hands with ...

  1. Hepatitis A FAQs

    Science.gov (United States)

    ... there are poor sanitary conditions or poor personal hygiene. The food and drinks most likely to be contaminated are ... restaurant has Hepatitis A. However, if an infected food handler is infectious and has poor hygiene, the risk goes up for patrons of that ...

  2. Premenstrual Syndrome (PMS) FAQ

    Science.gov (United States)

    ... depression. Aerobic exercise, which includes brisk walking, running, cycling, and swimming, increases your heart rate and lung ... help relieve PMS symptoms? Simple changes in your diet may help relieve the symptoms of PMS: Eat ...

  3. Polycystic Ovary Syndrome FAQ

    Science.gov (United States)

    ... is one of the most common causes of female infertility. • Obesity—Up to 80% of women with PCOS ... Endometrium: The lining of the uterus. Estrogen: A female hormone ... of various organs. Infertility: A condition in which a couple has been ...

  4. Onchocerciasis (River Blindness) FAQs

    Science.gov (United States)

    ... The CDC Parasites - Onchocerciasis (also known as River Blindness) Note: Javascript is disabled or is not supported ... infected Simulium blackfly. It is also called River Blindness because the fly that transmits infection breeds in ...

  5. Photoshop Lightroom 4 FAQs

    CERN Document Server

    Sholik, Stan

    2012-01-01

    Get the answers to 365 of the most commonly asked questions about Lightroom Photographers who are getting acquainted with Photoshop Lightroom and all its advantages for managing large quantities of images will find this handy book an indispensable resource. Veteran photographer Stan Sholik answers 365 of the most frequently asked questions about the new Lightroom 4 in an informative, practical format, making it easy to find what you're looking for and put the information to use. Sample photos illustrate questions and answers, and a quick-reference guide provides easy access to must-have inform

  6. Elder Abuse FAQS

    Science.gov (United States)

    ... not reported) in 2013. 17 A study from Germany had an overall rate of 3.1%: 2. ... Best Guess’ National Estimate and the Momentum for Reform,” Future Trends in State Courts 2011, National Center ...

  7. Genetics Home Reference: familial restrictive cardiomyopathy

    Science.gov (United States)

    ... Home Health Conditions familial restrictive cardiomyopathy familial restrictive cardiomyopathy Enable Javascript to view the expand/collapse boxes. ... All Open All Close All Description Familial restrictive cardiomyopathy is a genetic form of heart disease. For ...

  8. Molecular motion in restricted geometries

    Indian Academy of Sciences (India)

    Siddharth Gautam; S Mitra; R Mukhopadhyay

    2008-10-01

    Molecular dynamics in restricted geometries is known to exhibit anomalous behaviour. Diffusion, translational or rotational, of molecules is altered significantly on confinement in restricted geometries. Quasielastic neutron scattering (QENS) offers a unique possibility of studying molecular motion in such systems. Both time scales involved in the motion and the geometry of motion can be studied using QENS. Molecular dynamics (MD) simulation not only provides insight into the details of the different types of motion possible but also does not suffer limitations of the experimental set-up. Here we report the effect of confinement on molecular dynamics in various restricted geometries as studied by QENS and MD simulations: An example where the QENS technique provided direct evidence of phase transition associated with change in the dynamical behaviour of the molecules is also discussed.

  9. Telomere Restriction Fragment (TRF) Analysis

    Science.gov (United States)

    Mender, Ilgen; Shay, Jerry W.

    2016-01-01

    While telomerase is expressed in ~90% of primary human tumors, most somatic tissue cells except transiently proliferating stem-like cells do not have detectable telomerase activity (Shay and Wright, 1996; Shay and Wright, 2001). Telomeres progressively shorten with each cell division in normal cells, including proliferating stem-like cells, due to the end replication (lagging strand synthesis) problem and other causes such as oxidative damage, therefore all somatic cells have limited cell proliferation capacity (Hayflick limit) (Hayflick and Moorhead, 1961; Olovnikov, 1973). The progressive telomere shortening eventually leads to growth arrest in normal cells, which is known as replicative senescence (Shay et al., 1991). Once telomerase is activated in cancer cells, telomere length is stabilized by the addition of TTAGGG repeats to the end of chromosomes, thus enabling the limitless continuation of cell division (Shay and Wright, 1996; Shay and Wright, 2001). Therefore, the link between aging and cancer can be partially explained by telomere biology. There are many rapid and convenient methods to study telomere biology such as Telomere Restriction Fragment (TRF), Telomere Repeat Amplification Protocol (TRAP) (Mender and Shay, 2015b) and Telomere dysfunction Induced Foci (TIF) analysis (Mender and Shay, 2015a). In this protocol paper we describe Telomere Restriction Fragment (TRF) analysis to determine average telomeric length of cells. Telomeric length can be indirectly measured by a technique called Telomere Restriction Fragment analysis (TRF). This technique is a modified Southern blot, which measures the heterogeneous range of telomere lengths in a cell population using the length distribution of the terminal restriction fragments (Harley et al., 1990; Ouellette et al., 2000). This method can be used in eukaryotic cells. The description below focuses on the measurement of human cancer cells telomere length. The principle of this method relies on the lack of

  10. CDRL - company dose restriction level

    International Nuclear Information System (INIS)

    For a number of year's close constraints and controls have been used as effective measures in aiding restricting exposure to ionising radiation. Predecessor companies to British Energy Generation (BEG) originally established the Company Dose Restriction Level (CDRL) as a consequence of the revision of risk estimates, then with the revised Ionising Radiations Regulations 1999 (IRR99) the CDRL for BEG was also revised. The background, influences and consequences of CDRL appliance in a commercial organisation in calendar year 2000/1 are presented below. (author)

  11. HFB in a restricted space

    International Nuclear Information System (INIS)

    A restricted Hartree-Fock-Bogoliubov method is developed with a restriction on the angular momenta of the Cooper pairs that conform the vacuum (SD or SDG). The method is applied to 176Yb. The quadrupole moment in the SD subspace is found to be 80% for neutrons and 91% for protons of its value in the full space. The inclusion of the G part of the Cooper pairs improves that agreement. The descriptions in terms of boson condensate and coherent states are discussed. (author)

  12. Space-restricted attribute grammars

    DEFF Research Database (Denmark)

    Schmidt, Erik Meineche

    1980-01-01

    Restricting the size of attribute values, relative to the length of the string under consideration, leads to a model of attribute grammars in which grammars with both inherited and synthesized attributes can be significantly more economical than grammars with synthesized attributes only....

  13. Alphavirus Restriction by IFITM Proteins.

    Science.gov (United States)

    Weston, Stuart; Czieso, Stephanie; White, Ian J; Smith, Sarah E; Wash, Rachael S; Diaz-Soria, Carmen; Kellam, Paul; Marsh, Mark

    2016-09-01

    Interferon inducible transmembrane proteins (IFITMs) are broad-spectrum antiviral factors. In cell culture the entry of many enveloped viruses, including orthomyxo-, flavi-, and filoviruses, is inhibited by IFITMs, though the mechanism(s) involved remain unclear and may vary between viruses. We demonstrate that Sindbis and Semliki Forest virus (SFV), which both use endocytosis and acid-induced membrane fusion in early endosomes to infect cells, are restricted by the early endosomal IFITM3. The late endosomal IFITM2 is less restrictive and the plasma membrane IFITM1 does not inhibit normal infection by either virus. IFITM3 inhibits release of the SFV capsid into the cytosol, without inhibiting binding, internalization, trafficking to endosomes or low pH-induced conformational changes in the envelope glycoprotein. Infection by SFV fusion at the cell surface was inhibited by IFITM1, but was equally inhibited by IFITM3. Furthermore, an IFITM3 mutant (Y20A) that is localized to the plasma membrane inhibited infection by cell surface fusion more potently than IFITM1. Together, these results indicate that IFITMs, in particular IFITM3, can restrict alphavirus infection by inhibiting viral fusion with cellular membranes. That IFITM3 can restrict SFV infection by fusion at the cell surface equivalently to IFITM1 suggests that IFITM3 has greater antiviral potency against SFV. PMID:27219333

  14. Restricted Morgan’s problem

    Institute of Scientific and Technical Information of China (English)

    陈树中; 曹立

    1996-01-01

    A new list of regular feedback invariant integers called right independent orders is introduced.That the restricted Morgan’s problem is equivalent to a kind of nonlinear algebraic equations is proved and the condition that the nonlinear algebraic equations degenerate into linear algebraic equations is given.

  15. Restrictive dermopathy and fetal behaviour

    NARCIS (Netherlands)

    Mulder, EJH; Beemer, FA; Stoutenbeek, P

    2001-01-01

    We report three siblings from consecutive pregnancies affected with restrictive dermopathy (RD). During the second pregnancy, fetal behavioural development and growth were studied extensively using ultrasound at 1-4 week intervals. Dramatic and sudden changes occurred in fetal body movements and gro

  16. 49 CFR 215.203 - Restricted cars.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Restricted cars. 215.203 Section 215.203..., DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Restricted Equipment § 215.203 Restricted cars. (a) This section restricts the operation of any railroad freight car that is— (1) More than...

  17. MarFS-Requirements-Design-Configuration-Admin

    Energy Technology Data Exchange (ETDEWEB)

    Kettering, Brett Michael [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Grider, Gary Alan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)

    2015-07-08

    This document will be organized into sections that are defined by the requirements for a file system that presents a near-POSIX (Portable Operating System Interface) interface to the user, but whose data is stored in whatever form is most efficient for the type of data being stored. After defining the requirement the design for meeting the requirement will be explained. Finally there will be sections on configuring and administering this file system. More and more, data dominates the computing world. There is a “sea” of data out there in many different formats that needs to be managed and used. “Mar” means “sea” in Spanish. Thus, this product is dubbed MarFS, a file system for a sea of data.

  18. Geographic Names Information System (GNIS) Admin Features

    Data.gov (United States)

    Department of Homeland Security — The Geographic Names Information System (GNIS) is the Federal standard for geographic nomenclature. The U.S. Geological Survey developed the GNIS for the U.S. Board...

  19. Salesforce CRM the definitive admin handbook

    CERN Document Server

    Goodey, Paul

    2013-01-01

    A practical guide which will help to discover how to setup and configure the Salesforce CRM application. It offers solutions and practical examples on how to further improve and maintain its functionality with clear systematic instructions. Being highly organized and compact, this book contains detailed instructions with screenshots, diagrams, and tips that clearly describe how you can administer and configure complex Salesforce CRM functionality with absolute ease.This book is for administrators who want to develop and strengthen their Salesforce CRM skills in the areas of configuration and s

  20. Management of fetal growth restriction

    OpenAIRE

    Alberry, M; Soothill, P

    2007-01-01

    Fetal growth restriction (FGR) is challenging because of the difficulties in reaching a definitive diagnosis of the cause and planning management. FGR is associated not only with a marked increased risk in perinatal mortality and morbidity but also with long‐term outcome risks. Combinations of fetal biometry, amniotic fluid volume, heart rate patterns, arterial and venous Doppler, and biophysical variables allow a comprehensive fetal evaluation of FGR. However, no evidence supports that the u...

  1. Electromagnetic Fields Restrictions and Approximation

    CERN Document Server

    Katsenelenbaum, Boris Z

    2003-01-01

    The fields scattered by metallic bodies or radiated by some types of antennas are created by the surfaces currents and therefore they are subject to some restrictions. The book is the first one where the properties of these fields are investigated in details. The properties have the important significance for the antenna synthesis, body shape reconstruction and other diffraction problems. The material of the book lies in the meetingpoint of the antenna theory, highfrequency electrodynamics and inverse scattering problems. The author is an internationally renowned investigator in the field of e

  2. Restrictions on trade in distribution services

    OpenAIRE

    Kaleeswaran Kalirajan

    2001-01-01

    Identifies and quantifies restrictions affecting domestic and international trade in distribution services - mainly wholesaling and retailing - in 38 economies, including Australia. The paper also explores the price and cost implications of restrictions in food distribution services.

  3. Bronchial Responsiveness in Patients with Restrictive Spirometry

    OpenAIRE

    Keddissi, Jean I.; Elya, Marwan K.; Farooq, Saif U.; Youness, Houssein A.; Kellie R. Jones; Ahmed Awab; Kinasewitz, Gary T.

    2013-01-01

    Background. Improvement in PFT after bronchodilators is characteristic of obstructive airway diseases such as COPD. However, improvement in patients with restrictive pattern is occasionally seen. We aim to determine the clinical significance of a bronchodilator responsive restrictive defect. Methods. Patients with restrictive spirometry and a bronchodilator study were identified at the University of Oklahoma and Oklahoma City VAMC between September 2003 and December 2009. Restriction was defi...

  4. 42 CFR 73.13 - Restricted experiments.

    Science.gov (United States)

    2010-10-01

    ... 42 Public Health 1 2010-10-01 2010-10-01 false Restricted experiments. 73.13 Section 73.13 Public... SELECT AGENTS AND TOXINS § 73.13 Restricted experiments. (a) An individual or entity may not conduct a restricted experiment with a HHS select agent or toxin unless approved by and conducted in accordance...

  5. Restrictive Cardiomyopathy: A Rare Case Report

    Directory of Open Access Journals (Sweden)

    Bilal Bin Abdullah*, Mehboob.M.Kalburgi, Sahana Shetty and Satyasrinivas

    2011-04-01

    Full Text Available We report a 28 years old male presenting with heart failure. A thorough clinical evaluation directed us towards restrictive heart disease. Doppler echocardiographic study was used as a main modality of diagnosis and cardiac catheterization confirmed the diagnosis of idiopathic restrictive cardiomyopathy. We express the contribution of clinical findings and appropriate diagnostic measures in approaching a case of Restrictive cardiomyopathy (RCM.

  6. 50 CFR 648.204 - Possession restrictions.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Possession restrictions. 648.204 Section... Atlantic Herring Fishery § 648.204 Possession restrictions. (a) A vessel must be issued a valid limited... with no possession restriction from any of the herring management areas defined in §...

  7. Gentile statistics and restricted partitions

    Indian Academy of Sciences (India)

    C S Srivatsan; M V N Murthy; R K Bhaduri

    2006-03-01

    In a recent paper (Tran et al, Ann. Phys. 311, 204 (2004)), some asymptotic number theoretical results on the partitioning of an integer were derived exploiting its connection to the quantum density of states of a many-particle system. We generalise these results to obtain an asymptotic formula for the restricted or coloured partitions $p_{k}^{s} (n)$, which is the number of partitions of an integer into the summand of th powers of integers such that each power of a given integer may occur utmost times. While the method is not rigorous, it reproduces the well-known asymptotic results for = 1 apart from yielding more general results for arbitrary values of .

  8. Stillbirth and fetal growth restriction.

    Science.gov (United States)

    Bukowski, Radek

    2010-09-01

    The association between stillbirth and fetal growth restriction is strong and supported by a large body of evidence and clinically employed for the stillbirth prediction. However, although assessment of fetal growth is a basis of clinical practice, it is not trivial. Essentially, fetal growth is a result of the genetic growth potential of the fetus and placental function. The growth potential is the driving force of fetal growth, whereas the placenta as the sole source of nutrients and oxygen might become the rate limiting element of fetal growth if its function is impaired. Thus, placental dysfunction may prevent the fetus from reaching its full genetically determined growth potential. In this sense fetal growth and its aberration provides an insight into placental function. Fetal growth is a proxy for the test of the effectiveness of placenta, whose function is otherwise obscured during pregnancy.

  9. Asymptotics for restricted integer compositions

    CERN Document Server

    Malandro, Martin E

    2011-01-01

    We study the compositions of an integer n where the part sizes of the compositions are restricted to lie in a finite set. We obtain asymptotic formulas for the number of such compositions, the total and average number of parts among all such compositions, and the total and average number of times a particular part size appears among all such compositions. Several of our asymptotics have the additional property that their absolute errors---not just their percentage errors---go to 0 as n goes to infinity. Along the way we also obtain recurrences and generating functions for calculating several of these quantities. Our asymptotic formulas come from the meromorphic analysis of our generating functions. Our results also apply to questions about certain kinds of tilings and rhythm patterns.

  10. INTERPOLATION WITH RESTRICTED ARC LENGTH

    Institute of Scientific and Technical Information of China (English)

    Petar Petrov

    2003-01-01

    For given data (ti,yi), I= 0,1,…,n,0 = t0 <t1 <…<tn = 1we study constrained interpolation problem of Favard type inf{‖f"‖∞|f∈W2∞[0,1],f(ti)=yi,i=0,…,n,l(f;[0,1])≤l0}, wherel(f";[0,1])=∫1 0 / 1+f'2(x)dx is the arc length off in [0,1]. We prove the existence of a solution f* of the above problem, that is a quadratic spline with a second derivative f"* , which coincides with one of the constants - ‖f"*‖∞,0,‖f"*‖∞ between every two consecutive knots. Thus, we extend a result ofKarlin concerning Favard problem, to the case of restricted length interpolation.

  11. Achieving Salt Restriction in Chronic Kidney Disease

    Directory of Open Access Journals (Sweden)

    Emma J. McMahon

    2012-01-01

    Full Text Available There is consistent evidence linking excessive dietary sodium intake to risk factors for cardiovascular disease and chronic kidney disease (CKD progression in CKD patients; however, additional research is needed. In research trials and clinical practice, implementing and monitoring sodium intake present significant challenges. Epidemiological studies have shown that sodium intake remains high, and intervention studies have reported varied success with participant adherence to a sodium-restricted diet. Examining barriers to sodium restriction, as well as factors that predict adherence to a low sodium diet, can aid researchers and clinicians in implementing a sodium-restricted diet. In this paper, we critically review methods for measuring sodium intake with a specific focus on CKD patients, appraise dietary adherence, and factors that have optimized sodium restriction in key research trials and discuss barriers to sodium restriction and factors that must be considered when recommending a sodium-restricted diet.

  12. Placental Adaptations in Growth Restriction

    Directory of Open Access Journals (Sweden)

    Song Zhang

    2015-01-01

    Full Text Available The placenta is the primary interface between the fetus and mother and plays an important role in maintaining fetal development and growth by facilitating the transfer of substrates and participating in modulating the maternal immune response to prevent immunological rejection of the conceptus. The major substrates required for fetal growth include oxygen, glucose, amino acids and fatty acids, and their transport processes depend on morphological characteristics of the placenta, such as placental size, morphology, blood flow and vascularity. Other factors including insulin-like growth factors, apoptosis, autophagy and glucocorticoid exposure also affect placental growth and substrate transport capacity. Intrauterine growth restriction (IUGR is often a consequence of insufficiency, and is associated with a high incidence of perinatal morbidity and mortality, as well as increased risk of cardiovascular and metabolic diseases in later life. Several different experimental methods have been used to induce placental insufficiency and IUGR in animal models and a range of factors that regulate placental growth and substrate transport capacity have been demonstrated. While no model system completely recapitulates human IUGR, these animal models allow us to carefully dissect cellular and molecular mechanisms to improve our understanding and facilitate development of therapeutic interventions.

  13. Cardiac MRI in restrictive cardiomyopathy

    Energy Technology Data Exchange (ETDEWEB)

    Gupta, A. [Department of Cardiovascular Radiology, All India Institute of Medical Sciences, Ansari Nagar, Delhi (India); Singh Gulati, G., E-mail: gulatigurpreet@rediffmail.com [Department of Cardiovascular Radiology, All India Institute of Medical Sciences, Ansari Nagar, Delhi (India); Seth, S. [Department of Cardiology, All India Institute of Medical Sciences, Ansari Nagar, Delhi (India); Sharma, S. [Department of Cardiovascular Radiology, All India Institute of Medical Sciences, Ansari Nagar, Delhi (India)

    2012-02-15

    Restrictive cardiomyopathy (RCM) is a specific group of heart muscle disorders characterized by inadequate ventricular relaxation during diastole. This leads to diastolic dysfunction with relative preservation of systolic function. Although short axis systolic function is usually preserved in RCM, the long axis systolic function may be severely impaired. Confirmation of diagnosis and information regarding aetiology, extent of myocardial damage, and response to treatment requires imaging. Importantly, differentiation from constrictive pericarditis (CCP) is needed, as only the latter is managed surgically. Echocardiography is the initial cardiac imaging technique but cannot reliably suggest a tissue diagnosis; although recent advances, especially tissue Doppler imaging and spectral tracking, have improved its ability to differentiate RCM from CCP. Cardiac catheterization is the reference standard, but is invasive, two-dimensional, and does not aid myocardial characterization. Cardiac magnetic resonance (CMR) is a versatile technique providing anatomical, morphological and functional information. In recent years, it has been shown to provide important information regarding disease mechanisms, and also been found useful to guide treatment, assess its outcome and predict patient prognosis. This review describes the CMR features of RCM, appearances in various diseases, its overall role in patient management, and how it compares with other imaging techniques.

  14. Measuring Regulatory Restrictions in Logistics Services

    OpenAIRE

    Hollweg, Claire; Marn-Heong WONG

    2009-01-01

    This study measures the extent of restrictions on trade in logistics services in the ASEAN+6 economies by constructing a logistics regulatory restrictiveness index for each economy that quantifies the extent of government regulations faced by logistics service providers. This is the first study of its kind to construct a regulatory index of the entire logistics sector, which includes the main modes of international transport and customs restrictions. The indices show that large differences ex...

  15. Massively parallel characterization of restriction endonucleases

    OpenAIRE

    Kamps-Hughes, Nick; Quimby, Aine; Zhu, Zhenyu; Johnson, Eric A.

    2013-01-01

    Restriction endonucleases are highly specific in recognizing the particular DNA sequence they act on. However, their activity is affected by sequence context, enzyme concentration and buffer composition. Changes in these factors may lead to either ineffective cleavage at the cognate restriction site or relaxed specificity allowing cleavage of degenerate ‘star’ sites. Additionally, uncharacterized restriction endonucleases and engineered variants present novel activities. Traditionally, restri...

  16. 40 CFR 1033.740 - Credit restrictions.

    Science.gov (United States)

    2010-07-01

    ... restrictions. Use of emission credits generated under this part 1033 or 40 CFR part 92 is restricted depending on the standards against which they were generated. (a) Credits from 40 CFR part 92. NOX and PM credits generated under 40 CFR part 92 may be used under this part in the same manner as NOX and...

  17. Restricting mutualistic partners to enforce trade reliance

    Science.gov (United States)

    Wyatt, Gregory A. K.; Kiers, E. Toby; Gardner, Andy; West, Stuart A.

    2016-01-01

    Mutualisms are cooperative interactions between members of different species, often involving the trade of resources. Here, we suggest that otherwise-cooperative mutualists might be able to gain a benefit from actively restricting their partners' ability to obtain resources directly, hampering the ability of the restricted partner to survive and/or reproduce without the help of the restricting mutualist. We show that (i) restriction can be favoured when it makes the resources of the restricting individual more valuable to their partner, and thus allows them to receive more favourable terms of trade; (ii) restriction maintains cooperation in conditions where cooperative behaviour would otherwise collapse; and (iii) restriction can lead to either an increase or decrease in a restricted individual's fitness. We discuss the applicability of this scenario to mutualisms such as those between plants and mycorrhizal fungi. These results identify a novel conflict in mutualisms as well as several public goods dilemmas, but also demonstrate how conflict can help maintain cooperation. PMID:26813888

  18. 44 CFR 402.2 - Restricted commodities.

    Science.gov (United States)

    2010-10-01

    ... Positive List (15 CFR part 399) (as amended from time to time) of the Comprehensive Export Schedule of the... 44 Emergency Management and Assistance 1 2010-10-01 2010-10-01 false Restricted commodities. 402.2... SHIPMENTS ON AMERICAN FLAG SHIPS AND AIRCRAFT (T-1, INT. 1) § 402.2 Restricted commodities. The...

  19. 50 CFR 648.25 - Possession restrictions.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Possession restrictions. 648.25 Section 648.25 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND ATMOSPHERIC... Atlantic Mackerel, Squid, and Butterfish Fisheries § 648.25 Possession restrictions. (a) Atlantic...

  20. 50 CFR 648.105 - Possession restrictions.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Possession restrictions. 648.105 Section... Summer Flounder Fisheries § 648.105 Possession restrictions. (a) Unless otherwise specified pursuant to... for a summer flounder moratorium permit are subject to this possession limit. The owner, operator,...

  1. 50 CFR 648.164 - Possession restrictions.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Possession restrictions. 648.164 Section... Atlantic Bluefish Fishery § 648.164 Possession restrictions. (a) No person shall possess more than 15... is not issued a bluefish commercial permit are subject to this possession limit. The owner,...

  2. Smoking restrictions in private workplaces in Singapore.

    Science.gov (United States)

    Koh, Y H; Voo, Y O; Yong, L S

    1994-06-01

    This survey aims to determine the number and profile of private workplaces in Singapore which have a smoking restriction policy. The response rate was 43%. Of the companies which responded, 59% had some form of smoking restriction. Private companies are more likely to have a smoking restriction policy: (a) where smoking poses inherent fire risks, such as those dealing with inflammable chemicals or gases; (b) where smoking poses inherent detrimental effects to the quality of the products, such as those dealing with precision electronic microcomponents, where a smoke-free and dust-free environment is essential; (c) are larger companies; and (d) have strong management support in initiating and enforcing smoking restriction. Future programmes should give more emphasis to the service industries such as construction, insurance, banking and finance, and smaller companies (with fewer than 100 employees). They should involve the management who play an important role in implementing smoking restriction at their workplace. PMID:7997897

  3. Near BPS skyrmions and restricted harmonic maps

    Science.gov (United States)

    Speight, J. M.

    2015-06-01

    Motivated by a class of near BPS Skyrme models introduced by Adam, Sánchez-Guillén and Wereszczyński, the following variant of the harmonic map problem is introduced: a map φ :(M, g) →(N, h) between Riemannian manifolds is restricted harmonic if it locally extremizes E2 on its SDiff(M) orbit, where SDiff(M) denotes the group of volume preserving diffeomorphisms of (M, g), and E2 denotes the Dirichlet energy. It is conjectured that near BPS skyrmions tend to restricted harmonic maps in the BPS limit. It is shown that φ is restricted harmonic if and only if φ∗ h has exact divergence, and a linear stability theory of restricted harmonic maps is developed, from which it follows that all weakly conformal maps are stable restricted harmonic. Examples of restricted harmonic maps in every degree class R3 → SU(2) and R2 →S2 are constructed. It is shown that the axially symmetric BPS skyrmions on which all previous analytic studies of near BPS Skyrme models have been based, are not restricted harmonic, casting doubt on the phenomenological predictions of such studies. The problem of minimizing E2 for φ :Rk → N over all linear volume preserving diffeomorphisms is solved explicitly, and a deformed axially symmetric family of Skyrme fields constructed which are candidates for approximate near BPS skyrmions at low baryon number. The notion of restricted harmonicity is generalized to restricted F-criticality where F is any functional on maps (M, g) →(N, h) which is, in a precise sense, geometrically natural. The case where F is a linear combination of E2 and E4, the usual Skyrme term, is studied in detail, and it is shown that inverse stereographic projection R3 →S3 ≡ SU(2) is stable restricted F-critical for every such F.

  4. Measuring the Restrictiveness of Living Environments for Children and Youth: Reconceptualizing Restriction

    Science.gov (United States)

    Rauktis, Mary E.; Huefner, Jonathan C.; O'Brien, Kirk; Pecora, Peter J.; Doucette, Ann; Thompson, Ronald W.

    2009-01-01

    The "Restrictiveness of Living Environment Scale" has long been the primary way to conceptualize the "restrictiveness" of a child's living situation. However, changes in systems of care and other factors have created a need to revisit how restrictiveness is conceptualized and measured. A measure was created to assess an environment's level of…

  5. Restriction beyond the restriction point: mitogen requirement for G2 passage

    Directory of Open Access Journals (Sweden)

    te Riele Hein

    2006-05-01

    Full Text Available Abstract Cell proliferation is dependent on mitogenic signalling. When absent, normal cells cannot pass the G1 restriction point, resulting in cell cycle arrest. Passage through the G1 restriction point involves inactivation of the retinoblastoma protein family. Consequently, loss of the retinoblastoma protein family leads to loss of the G1 restriction point. Recent work in our lab has revealed that cells possess yet another mechanism that restricts proliferation in the absence of mitogens: arrest in the G2 phase of the cell cycle. Here, we discuss the similarities and differences between these restriction points and the roles of cyclin-dependent kinase inhibitors (CKIs herein.

  6. Urban water restrictions: Attitudes and avoidance

    Science.gov (United States)

    Cooper, Bethany; Burton, Michael; Crase, Lin

    2011-12-01

    In most urban cities across Australia, water restrictions remain the dominant policy mechanism to restrict urban water consumption. The extensive adoption of water restrictions as a means to limit demand, over several years, means that Australian urban water prices have consistently not reflected the opportunity cost of water. Given the generally strong political support for water restrictions and the likelihood that they will persist for some time, there is value in understanding households' attitudes in this context. More specifically, identifying the welfare gains associated with avoiding urban water restrictions entirely would be a nontrivial contribution to our knowledge and offer insights into the benefits of alternative policy responses. This paper describes the results from a contingent valuation study that investigates consumers' willingness to pay to avoid urban water restrictions. Importantly, the research also investigates the influence of cognitive and exogenous dimensions on the utility gain associated with avoiding water restrictions. The results provide insights into the impact of the current policy mechanism on economic welfare.

  7. Methionine restriction and life-span control.

    Science.gov (United States)

    Lee, Byung Cheon; Kaya, Alaattin; Gladyshev, Vadim N

    2016-01-01

    Dietary restriction (DR) without malnutrition is associated with longevity in various organisms. However, it has also been shown that reduced calorie intake is often ineffective in extending life span. Selecting optimal dietary regimens for DR studies is complicated, as the same regimen may lead to different outcomes depending on genotype and environmental factors. Recent studies suggested that interventions such as moderate protein restriction with or without adequate nutrition (e.g., particular amino acids or carbohydrates) may have additional beneficial effects mediated by certain metabolic and hormonal factors implicated in the biology of aging, regardless of total calorie intake. In particular, it was shown that restriction of a single amino acid, methionine, can mimic the effects of DR and extend life span in various model organisms. We discuss the beneficial effects of a methionine-restricted diet, the molecular pathways involved, and the use of this regimen in longevity interventions.

  8. Age-restricted housing in New England

    OpenAIRE

    Peter Francese

    2008-01-01

    Fair Housing Act amendments exempt housing restricted to “older persons” from provisions protecting families with children from discrimination. But municipal leaders who believe that promoting over-55 housing will reduce education costs are in for a rude awakening.

  9. Avoidant/Restrictive Food Intake Disorder

    Science.gov (United States)

    ... Intake Disorder Binge Eating Disorder Bulimia Nervosa Pica Rumination Disorder Avoidant/restrictive food intake disorder is characterized ... Intake Disorder Binge Eating Disorder Bulimia Nervosa Pica Rumination Disorder NOTE: This is the Consumer Version. CONSUMERS: ...

  10. The Frattini Subalgebra of Restricted Lie Superalgebras

    Institute of Scientific and Technical Information of China (English)

    Liang Yun CHEN; Dao Ji MENG; Yong Zheng ZHANG

    2006-01-01

    In the present paper, we study the Frattini subalgebra of a restricted Lie superalgebra (L, [p]). We show first that if L = A1 (⊙) A2 (⊙) … (⊙) An, then φp (L) = φp (A1) + φp (A2) +… +φp (An),where each Ai is a p-ideal of L. We then obtain two results: F(L) = φ(L) = J(L) = L(1) if and only if L is nilpotent; Fp(L) and F(L) are nilpotent ideals of L if L is solvable. In addition, necessary and sufficient conditions are found for φp-free restricted Lie superalgebras. Finally, we discuss the relationships of E-p-restricted Lie superalgebras and E-restricted Lie superalgebras.

  11. Bound on m-restricted Edge Connectivity

    Institute of Scientific and Technical Information of China (English)

    Jian-ping Ou; Fu-ji Zhang

    2003-01-01

    An m-restricted edge cut is an edge cut that separates a connected graph into a disconnected one with no components having order less than m. m-restricted edge connectivity λm is the cardinality of a minimum m-restricted edge cut. Let G be a connected k-regular graph of order at least 2m that contains m-restricted edge cuts and X be a subgraph of G. Let( )(X) denote the number of edges with one end in X and the other not in X and ξm = min{( )(X): X is a connected vertex-induced subgraph of order m}. It is proved in this paper that if G has girth at least m/2 + 2, then λm ≤ξm. The upper bound of λm is sharp.

  12. Restrictions on Database Use: Are They Necessary?

    Science.gov (United States)

    Molster, H. C.

    1979-01-01

    Discusses restrictions regarding use of bibliographic data bases, cites their rationale in terms of cooperation in input creation, economics and administrative control, and notes their effect on use. (Author/CWM)

  13. Restriction/modification polypeptides, polynucleotides, and methods

    Energy Technology Data Exchange (ETDEWEB)

    Westpheling, Janet; Chung, DaeHwan; Huddleston, Jennifer; Farkas, Joel A

    2015-02-24

    The present invention relates to the discovery of a novel restriction/modification system in Caldicellulosiruptor bescii. The discovered restriction enzyme is a HaeIII-like restriction enzyme that possesses a thermophilic activity profile. The restriction/modification system also includes a methyltransferase, M.CbeI, that methylates at least one cytosine residue in the CbeI recognition sequence to m.sup.4C. Thus, the invention provides, in various aspects, isolated CbeI or M.CbeI polypeptides, or biologically active fragments thereof; isolated polynucleotides that encode the CbeI or M.CbeI polypeptides or biologically active fragments thereof, including expression vectors that include such polynucleotide sequences; methods of digesting DNA using a CbeI polypeptide; methods of treating a DNA molecule using a M.CbeI polypeptide; and methods of transforming a Caldicellulosiruptor cell.

  14. Behavioral and Physiological Consequences of Sleep Restriction

    OpenAIRE

    Banks, Siobhan; Dinges, David F.

    2007-01-01

    Adequate sleep is essential for general healthy functioning. This paper reviews recent research on the effects of chronic sleep restriction on neurobehavioral and physiological functioning and discusses implications for health and lifestyle. Restricting sleep below an individual's optimal time in bed (TIB) can cause a range of neurobehavioral deficits, including lapses of attention, slowed working memory, reduced cognitive throughput, depressed mood, and perseveration of thought. Neurobehavio...

  15. Public Investment, Revenue Shocks, and Borrowing Restrictions

    OpenAIRE

    Büttner, Thiess; David E. Wildasin

    2010-01-01

    This paper lays out a theory of taxation and public investment in an intertemporal setting under conditions of revenue shocks. Without borrowing restrictions, the optimal policy is characterized by smooth time paths of taxes and public investment. While the introduction of formal borrowing restrictions leads to some precautionary savings, it gives rise to fluctuations in public investment in response to adverse but also favorable revenue shocks. This theoretical result is tested empirically u...

  16. Cellular Restriction Factors of Feline Immunodeficiency Virus

    OpenAIRE

    Carsten Münk; Jörg Zielonka

    2011-01-01

    Lentiviruses are known for their narrow cell- and species-tropisms, which are determined by cellular proteins whose absence or presence either support viral replication (dependency factors, cofactors) or inhibit viral replication (restriction factors). Similar to Human immunodeficiency virus type 1 (HIV-1), the cat lentivirus Feline immunodeficiency virus (FIV) is sensitive to recently discovered cellular restriction factors from non-host species that are able to stop viruses from replicating...

  17. Placental Nutrient Transport and Intrauterine Growth Restriction

    OpenAIRE

    Gaccioli, Francesca; Lager, Susanne

    2016-01-01

    Intrauterine growth restriction refers to the inability of the fetus to reach its genetically determined potential size. Fetal growth restriction affects approximately 5–15% of all pregnancies in the United States and Europe. In developing countries the occurrence varies widely between 10 and 55%, impacting about 30 million newborns per year. Besides having high perinatal mortality rates these infants are at greater risk for severe adverse outcomes, such as hypoxic ischemic encephalopathy and...

  18. Feed restriction in broiler chickens production

    OpenAIRE

    Sahraei M.

    2012-01-01

    The feed restriction program is on of the main techniques in growth curve manipulation for increasing production efficiency in broiler chicken. Quantities and qualitative feed restriction are procedures that can be used to manipulate the feeding strategies of poultry in order to decrease growth and metabolic rate to some extent and so alleviate the incidence of some metabolic diseases such as ascites, lameness, mortality, and sudden death syndrome and so im...

  19. Date restricted queries in web search engines

    OpenAIRE

    Lewandowski, Dirk

    2004-01-01

    Search engines usually offer a date restricted search on their advanced search pages. But determining the actual update of a web page is not without problems. We conduct a study testing date restricted queries on the search engines Google, Teoma and Yahoo!. We find that these searches fail to work properly in the examined engines. We discuss implications of this for further research and search engine development.

  20. Restricted three body problems at the nanoscale

    OpenAIRE

    Chan, Yue; Thamwattana, Ngamta; Hill, James M.

    2009-01-01

    In this paper, we investigate some of the classical restricted three body problems at the nanoscale, such as the circular planar restricted problem for three C60 fullerenes, and a carbon atom and two C60 fullerenes. We model the van der Waals forces between the fullerenes by the Lennard-Jones potential. In particular, the pairwise potential energies between the carbon atoms on the fullerenes are approximated by the continuous approach, so that the total molecular energy between two fullerenes...

  1. Temporary Tariffs and Capital Market Restrictions

    OpenAIRE

    Saqib Jafarey; Sajal Lahiri

    2004-01-01

    We develop a two-period model with endogenous investment and credit flows. Credit is subject to quantitative restrictions. With an exogenous restriction, we analyze the welfare effects of temporary tariffs. We then consider three scenarios under which a monopoly lender optimally decides the level of credit and a borrower country chooses an import tariff: one in which the two parties act simultaneously and two scenarios where one of them has a first-mover advantage. The equilibrium under the l...

  2. Economic FAQs About the Internet

    OpenAIRE

    MacKie-Mason, Jeffrey K.; Varian, Hal R.

    1996-01-01

    This is a set of Frequently Asked Questions (and answers) about the economic, institutional, and technological structure of the Internet. We describe the history and current state of the Internet, discuss some of the pressing economic and regulatory problems, and speculate about future developments.

  3. FAQs: Learning Languages through Drama.

    Science.gov (United States)

    Dodson, Sarah L.

    2000-01-01

    Using a format of frequently asked questions about teaching foreign languages using drama, this article explores the evolution of this approach, its benefits and drawbacks, and the various theatrical activities that can be used to teach languages. After describing how drama fits into the communicative approach to language teaching, the article…

  4. Scabies: Frequently Asked Questions (FAQs)

    Science.gov (United States)

    ... persons with crusted scabies are considered very infectious, careful vacuuming of furniture and carpets in rooms used ... a nurse or caretaker who works in a nursing home or hospital often would be treated prophylactically ...

  5. Klinefelter Syndrome (KS): Other FAQs

    Science.gov (United States)

    ... them to stay focused [top] Michael, J. (2008). Endodontic treatment in three taurodontic teeth associated with 48,XXXY Klinefelter syndrome: A review and case report. Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology and Endodontolog y , 105 (5), 670-677. [top] ...

  6. Hepatitis B Blood Tests: FAQ

    Science.gov (United States)

    ... 2 Billion People have been infected with Hepatitis B Worldwide The Hepatitis B Foundation is working on ... people living with hepatitis B. Learn About Hepatitis B in 10 Other Languages . Resource Video See More ...

  7. Triglycerides and Cardiovascular Disease: FAQ

    Science.gov (United States)

    ... sweet rolls and cinnamon toast. High fructose corn-syrup is 55% fructose, and 45% glucose - not 100% fructose. 9. Why are you singling ... on labels include: • Brown sugar • Corn sweetener • Corn ... fructose, glucose, lactose, maltose, sucrose) • High-fructose corn syrup • Fruit ...

  8. Cercarial Dermatitis (Swimmer's Itch) FAQs

    Science.gov (United States)

    ... visit this page: About CDC.gov . Parasites - Cercarial Dermatitis (also known as Swimmer's Itch) Parasites Home Share ... is swimmer's itch? Swimmer's itch, also called cercarial dermatitis, appears as a skin rash caused by an ...

  9. Breastfeeding FAQs: Pain and Discomfort

    Science.gov (United States)

    ... have an infection in your milk ducts called mastitis . If you have any of these symptoms, call ... If he or she finds that you have mastitis, the infection can be easily treated with antibiotics. ...

  10. FAQs on leg ulcer care.

    Science.gov (United States)

    Anderson, Irene; King, Brenda; Knight, Susan; Keynes, Milton

    In a webchat on leg ulcer management issues, hosted by Nursing Times, participants raised three key areas of care: the role of healthcare assistants in compression bandaging; reporting and investigating damage caused by compression therapy; and recommendations for dressings to be used under compression. This article discusses each of these in turn.

  11. Optimal control of entanglement under restrictions

    Energy Technology Data Exchange (ETDEWEB)

    Haeberle, Thomas Stefan; Freyberger, Matthias [Institut fuer Quantenphysik, Universitaet Ulm, D-89069 Ulm (Germany)

    2013-07-01

    We present a novel iterative algorithm with a special presearching step that can optimize the entanglement of a coupled quantum system while fulfilling restrictions of the control function. As an example we regard two atoms in a harmonic trap which interact via point-like collisions. Our aim is to improve the entanglement at a fixed time by dynamically varying the trap frequency within a fixed interval. In order to get rid of the restrictions for the trap frequency, we use a suitable parameterization that transforms the optimization problem from a restricted to an unrestricted one. By applying the pre-searching step we get a reasonable initial guess for the optimal trap frequency. Finally, we use a standard method based on optimal control theory to further increase the entanglement.

  12. Quantum Game with Restricted Matrix Strategies

    Institute of Scientific and Technical Information of China (English)

    CHENBo; MAYing-Jun; LONGGui-Lu

    2003-01-01

    We study a quantum game played by two players with restricted multiple strategies. It is found that in this restricted quantum game Nash equilibrium does not always exist when the initial state is entangled. At the same time,we find that when Nasli equilibrium exists the payoff function is usually different from that in the classical counterpart except in some special cases. This presents an explicit example showing quantum game and classical game may differ.When designing a quantum game with limited strategies, the allowed strategy should be carefully chosen according to the type of initial state.

  13. Quantum Game with Restricted Matrix Strategies

    Institute of Scientific and Technical Information of China (English)

    CHEN Bo; MA Ying-Jun; LONG Gui-Lu

    2003-01-01

    We study a quantum game played by two players with restricted multiple strategies. It is found that in this restricted quantum game Nash equilibrium does not always exist when the initial state is entangled. At the same time,we find that when Nash equilibrium exists the payoff function is usually different from that in the classical counterpart except in some special cases. This presents an explicit example showing quantum game and classical game may differ.When designing a quantum game with limited strategies, the allowed strategy should be carefully chosen according to the type of initial state.

  14. Restricted total stability and total attractivity

    Directory of Open Access Journals (Sweden)

    Giuseppe Zappala'

    2006-08-01

    Full Text Available In this paper the new concepts of restricted total stability and total attractivity is formulated. For this purpose the classical theory of Malkin with suitable changes and the theory of limiting equations, introduced by Sell developed by Artstein and Andreev, are used. Significant examples are presented.

  15. Real Moments of the Restrictive Factor

    Indian Academy of Sciences (India)

    Andrew Ledoan; Alexandru Zaharescu

    2009-09-01

    Let be a real number such that 0 < < 1. We establish asymptotic formulas for the weighted real moments $\\sum_{n≤ x}R^(n)(1-n/x)$, where $R(n)=\\prod^k_{v=1}p^{ v-1}_v$ is the Atanassov strong restrictive factor function and $n=\\prod^k_{v=1}p^{ v}_v$ is the prime factorization of .

  16. 45 CFR 400.44 - Restriction.

    Science.gov (United States)

    2010-10-01

    ... Regulations Relating to Public Welfare OFFICE OF REFUGEE RESETTLEMENT, ADMINISTRATION FOR CHILDREN AND FAMILIES, DEPARTMENT OF HEALTH AND HUMAN SERVICES REFUGEE RESETTLEMENT PROGRAM Immigration Status and Identification of Refugees Documentation of Refugee Status § 400.44 Restriction. An applicant for asylum is...

  17. 9 CFR 166.2 - General restrictions.

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false General restrictions. 166.2 Section 166.2 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE SWINE HEALTH PROTECTION SWINE HEALTH PROTECTION General Provisions § 166.2 General...

  18. Material and Cultural Restriction of Political Life

    Institute of Scientific and Technical Information of China (English)

    马国祥

    2015-01-01

    Material and culture have a certain influence on the political life. In general, the higher level of economic development of the country, people's political life is more democratic. Culture has some negative effect on the political life. China's traditional cul-ture has restricted the people's political life in some ways.

  19. Restricted Liberty, Parental Choice and Homeschooling

    Science.gov (United States)

    Merry, Michael S.; Karsten, Sjoerd

    2010-01-01

    In this paper the authors carefully study the problem of liberty as it applies to school choice, and whether there ought to be restricted liberty in the case of homeschooling. They examine three prominent concerns that might be brought against homeschooling, viz., that it aggravates social inequality, worsens societal conflict and works against…

  20. Restricted liberty, parental choice and homeschooling

    NARCIS (Netherlands)

    M.S. Merry; S. Karsten

    2010-01-01

    In this paper the authors carefully study the problem of liberty as it applies to school choice, and whether there ought to be restricted liberty in the case of homeschooling. They examine three prominent concerns that might be brought against homeschooling, viz., that it aggravates social inequalit

  1. Epigenetic regulation of caloric restriction in aging

    Directory of Open Access Journals (Sweden)

    Daniel Michael

    2011-08-01

    Full Text Available Abstract The molecular mechanisms of aging are the subject of much research and have facilitated potential interventions to delay aging and aging-related degenerative diseases in humans. The aging process is frequently affected by environmental factors, and caloric restriction is by far the most effective and established environmental manipulation for extending lifespan in various animal models. However, the precise mechanisms by which caloric restriction affects lifespan are still not clear. Epigenetic mechanisms have recently been recognized as major contributors to nutrition-related longevity and aging control. Two primary epigenetic codes, DNA methylation and histone modification, are believed to dynamically influence chromatin structure, resulting in expression changes of relevant genes. In this review, we assess the current advances in epigenetic regulation in response to caloric restriction and how this affects cellular senescence, aging and potential extension of a healthy lifespan in humans. Enhanced understanding of the important role of epigenetics in the control of the aging process through caloric restriction may lead to clinical advances in the prevention and therapy of human aging-associated diseases.

  2. Joint Venture Structuring in Restricted Industries

    Institute of Scientific and Technical Information of China (English)

    CHRIS; DEVONSHIRE-ELLIS

    2008-01-01

    When investing in China’s restricted in- dustries, it is essential to have a joint venture (JV) partner. Often the maximum percent- age of equity allowed in foreign ownership can only be 50 percent. So what options are available to the foreign investor to mitigate the risk of not owning, on paper, a majority

  3. Observing Behavior and Atypically Restricted Stimulus Control

    Science.gov (United States)

    Dube, William V.; Dickson, Chata A.; Balsamo, Lyn M.; O'Donnell, Kristin Lombard; Tomanari, Gerson Y.; Farren, Kevin M.; Wheeler, Emily E.; McIlvane, William J.

    2010-01-01

    Restricted stimulus control refers to discrimination learning with atypical limitations in the range of controlling stimuli or stimulus features. In the study reported here, 4 normally capable individuals and 10 individuals with intellectual disabilities (ID) performed two-sample delayed matching to sample. Sample-stimulus observing was recorded…

  4. 12 CFR 575.11 - Operating restrictions.

    Science.gov (United States)

    2010-01-01

    ..., the reference in § 563b.510 of this chapter to five percent refers to minority shareholders. (d) Restrictions on waiver of dividends. No mutual holding company may waive its right to receive any dividend... holding company provides the OTS with written notice of its intent to waive its right to receive...

  5. Restrictive dermopathy - Report of 12 cases

    NARCIS (Netherlands)

    Smitt, JHS; van Asperen, CJ; Niessen, CM; Beemer, FA; van Essen, AJ; Hulsmans, RFHJ; Oranje, AP; Steijlen, PM; Wesby-van Swaay, E; Tamminga, P; Breslau-Siderius, EJ

    1998-01-01

    Background: This study describes 12 cases of restrictive dermopathy seen during a period of 8 years by the Dutch Task Force on Genodermatology. We present these unique consecutive cases to provide more insight into the clinical picture and pathogenesis of the disease. Observations: Clinical features

  6. 46 CFR 119.405 - Fuel restrictions.

    Science.gov (United States)

    2010-10-01

    ... 46 Shipping 4 2010-10-01 2010-10-01 false Fuel restrictions. 119.405 Section 119.405 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE THAN 150 PASSENGERS OR WITH OVERNIGHT ACCOMMODATIONS FOR MORE THAN 49 PASSENGERS MACHINERY INSTALLATION...

  7. Design implications of extremely restricted patterning

    Science.gov (United States)

    Vaidyanathan, Kaushik; Liu, Renzhi; Liebmann, Lars; Lai, Kafai; Strojwas, Andzrej J.; Pileggi, Larry

    2014-07-01

    Escalating manufacturing cost and complexity is challenging the premise of affordable scaling. With lithography accounting for a large fraction of wafer costs, researchers are actively exploring several cost-effective alternative lithographic techniques, such as directed self-assembly, self-aligned multiple patterning, etc. However, most of the alternative lithographic techniques are restrictive, and it is important to understand the impact of such pattering restrictions on system-on-chip (SoC) design. To this end, we artificially restricted all layers in a 14 nm process to be pure gratings and observed that the pure gratings approach results in an inefficient SoC design with several process integration concerns. To come up with a technology definition that is mindful of designer requirements, it is essential to undertake a holistic design technology co-optimization (DTCO) considering several SoC design elements, such as standard cell logic, static random access memory bitcells, analog blocks, and physical synthesis. Our DTCO on the IBM 14 nm process with additional 10- and 7-nm node-like pattern restrictions leads us to converge on a set of critical pattern constructs that are required for an efficient and affordable SoC design.

  8. 7 CFR 322.28 - General requirements; restricted articles.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false General requirements; restricted articles. 322.28... EQUIPMENT Importation and Transit of Restricted Articles § 322.28 General requirements; restricted articles. (a) The following articles from any region are restricted articles: (1) Dead bees of any genus;...

  9. An unusual ECG pattern in restrictive cardimyopathy.

    Science.gov (United States)

    Selvaganesh, M; Arul, A S; Balasubramanian, S; Ganesan, N; Naina Mohammed, S; Sivakumar, G S; Veeramani, S R; Jeyasingh, P; Sathishkumar, S; Selvaraju, S

    2015-01-01

    Restrictive cardiomyopathy is the least common type of primary cardiomyopathies. Electrocardiographic recording is abnormal in 99% of patients with RCM. Biatrial enlargement, obliquely elevated ST segment with notched or biphasic late peaking T waves are considered characteristic ECG finding. Significant ST depression with T inversion mimicking subendocardial ischemia has also been reported in patients with RCM and is even suggested as a predictor of sudden cardiac death. We noted a similar ECG pattern in a 16 yr girl with Idiopathic restrictive cardiomyopathy. Coronaries were normal, stress perfusion imaging did not show any perfusion defect. This diffuse resting ST depression with T inversion in precordial & inferior leads along with ST elevation in aVR was persistent for more than six months. PMID:26304570

  10. A Property Restriction Based Knowledge Merging Method

    Science.gov (United States)

    Che, Haiyan; Chen, Wei; Feng, Tie; Zhang, Jiachen

    Merging new instance knowledge extracted from the Web according to certain domain ontology into the knowledge base (KB for short) is essential for the knowledge management and should be processed carefully, since this may introduce redundant or contradictory knowledge, and the quality of the knowledge in the KB, which is very important for a knowledge-based system to provide users high quality services, will suffer from such "bad" knowledge. Advocates a property restriction based knowledge merging method, it can identify the equivalent instances, redundant or contradictory knowledge according to the property restrictions defined in the domain ontology and can consolidate the knowledge about equivalent instances and discard the redundancy and conflict to keep the KB compact and consistent. This knowledge merging method has been used in a semantic-based search engine project: CRAB and the effect is satisfactory.

  11. Affective tone of mothers' statements to restrict their children's eating.

    Science.gov (United States)

    Pesch, Megan H; Miller, Alison L; Appugliese, Danielle P; Rosenblum, Katherine L; Lumeng, Julie C

    2016-08-01

    Maternal restrictive feeding behaviors have been associated with child weight status. The affective tone of mothers' statements intended to restrict their children's eating has not been examined. The objectives of this study were to describe the affective tone of mothers' restrictive feeding behaviors (positive or negative), and to test the association of child and mother characteristics with rates of Restriction with Positive Affect, Restriction with Negative Affect and Total Restriction. A total of 237 low-income child-mother dyads (mean child age 5.9 years) participated in a videotaped standardized laboratory eating protocol, during which mothers and children were both presented with large servings of cupcakes. A coding scheme was developed to count each restrictive statement with a positive affective tone and each restrictive statement with a negative affective tone. To establish reliability, 20% of videos were double-coded. Demographics and anthropometrics were obtained. Poisson regression models were used to test the association between characteristics of the child and mother with counts of Restriction with Positive Affect, Restriction with Negative Affect, and Total Restriction. Higher rates of Restriction with Positive Affect and Total Restriction were predicted by child obese weight status, and mother non-Hispanic white race/ethnicity. Higher rates of Restriction with Negative Affect were predicted by older child age, child obese weight status, mother non-Hispanic white race/ethnicity, and lower mother education level. In conclusion, in this study mothers of obese (vs. non-obese) children had higher rates of restriction in general, but particularly higher rates of Restriction with Negative Affect. Rather than being told not to restrict, mothers may need guidance on how to sensitively restrict their child's intake. Future studies should consider the contributions of maternal affect to children's responses to maternal restriction. PMID:27090342

  12. Blood flow-restricted exercise in space

    OpenAIRE

    Hackney, Kyle J; Everett, Meghan; Scott, Jessica M; Ploutz-Snyder, Lori

    2012-01-01

    Prolonged exposure to microgravity results in chronic physiological adaptations including skeletal muscle atrophy, cardiovascular deconditioning, and bone demineralization. To attenuate the negative consequences of weightlessness during spaceflight missions, crewmembers perform moderate- to high-load resistance exercise in conjunction with aerobic (cycle and treadmill) exercise. Recent evidence from ground-based studies suggests that low-load blood flow-restricted (BFR) resistance exercise tr...

  13. Privacy-Preserving Restricted Boltzmann Machine

    OpenAIRE

    Yu Li; Yuan Zhang; Yue Ji

    2014-01-01

    With the arrival of the big data era, it is predicted that distributed data mining will lead to an information technology revolution. To motivate different institutes to collaborate with each other, the crucial issue is to eliminate their concerns regarding data privacy. In this paper, we propose a privacy-preserving method for training a restricted boltzmann machine (RBM). The RBM can be got without revealing their private data to each other when using our privacy-preserving method. We provi...

  14. Free vs. Restricted Immigration: Bilateral Country Study

    OpenAIRE

    Razin, Assaf; Wahba, Jackline

    2011-01-01

    This paper tests the differential effects of the generosity of the welfare state under free migration and under policy-controlled migration, distinguishing between source developing and developed countries. We utilize free-movement within the EU to examine the free migration regime and compare that to immigration into the EU from two other groups, developed and developing source countries, to capture immigration-restricted regimes. We standardize cross-country education quality differences by...

  15. Geometry of the restricted Boltzmann machine

    OpenAIRE

    Cueto, Maria Angelica; Morton, Jason; Sturmfels, Bernd

    2009-01-01

    The restricted Boltzmann machine is a graphical model for binary random variables. Based on a complete bipartite graph separating hidden and observed variables, it is the binary analog to the factor analysis model. We study this graphical model from the perspectives of algebraic statistics and tropical geometry, starting with the observation that its Zariski closure is a Hadamard power of the first secant variety of the Segre variety of projective lines. We derive a dimension formula for the ...

  16. Chronic calorie restriction attenuates experimental autoimmune encephalomyelitis

    OpenAIRE

    Piccio, Laura; Stark, Jennifer L.; Cross, Anne H.

    2008-01-01

    Calorie restriction (CR) prevents many age-associated diseases and prolongs the lifespan. CR induces multiple metabolic and physiologic modifications, including anti-inflammatory, antioxidant, and neuroprotective effects that may be beneficial in multiple sclerosis (MS). The present studies sought to determine whether CR or increased calorie intake alters the course of experimental autoimmune encephalomyelitis (EAE), the leading animal model for MS. SJL and C57BL/6 mice were subjected to 40% ...

  17. Restricted Conformal Property of Compressive Sensing

    OpenAIRE

    Cheng, Tao

    2014-01-01

    Energy and direction are tow basic properties of a vector. A discrete signal is a vector in nature. RIP of compressive sensing can not show the direction information of a signal but show the energy information of a signal. Hence, RIP is not complete. Orthogonal matrices can preserve angles and lengths. Preservation of length can show energies of signals like RIP do; and preservation of angle can show directions of signals. Therefore, Restricted Conformal Property (RCP) is proposed according t...

  18. Early postnatal caloric restriction protects adult male intrauterine growth-restricted offspring from obesity.

    Science.gov (United States)

    Garg, Meena; Thamotharan, Manikkavasagar; Dai, Yun; Thamotharan, Shanthie; Shin, Bo-Chul; Stout, David; Devaskar, Sherin U

    2012-06-01

    Postnatal ad libitum caloric intake superimposed on intrauterine growth restriction (IUGR) is associated with adult-onset obesity, insulin resistance, and type 2 diabetes mellitus (T2DM). We hypothesized that this paradigm of prenatal nutrient deprivation-induced programming can be reversed with the introduction of early postnatal calorie restriction. Ten-month-old male rats exposed to either prenatal nutrient restriction with ad libitum postnatal intake (IUGR), pre- and postnatal nutrient restriction (IPGR), or postnatal nutrient restriction limited to the suckling phase (50% from postnatal [PN]1 to PN21) (PNGR) were compared with age-matched controls (CON). Visceral adiposity, metabolic profile, and insulin sensitivity by hyperinsulinemic-euglycemic clamps were examined. The 10-month-old male IUGR group had a 1.5- to 2.0-fold increase in subcutaneous and visceral fat (P metabolic inflexibility (Vo(2)) versus CON. The IPGR group remained lean, euglycemic, insulin sensitive, and active while maintaining metabolic flexibility. The PNGR group was insulin sensitive, similar to IPGR, but less active while maintaining metabolic flexibility. We conclude that IUGR resulted in obesity without insulin resistance and energy metabolic perturbations prior to development of glucose intolerance and T2DM. Postnatal nutrient restriction superimposed on IUGR was protective, restoring metabolic normalcy to a lean and active phenotype. PMID:22461568

  19. Team Formation and Communication Restrictions in Collectives

    Science.gov (United States)

    Agogino, Adrian K.; Turner, Kagan

    2003-01-01

    A collective of agents often needs to maximize a "world utility" function which rates the performance of an entire system, while subject to communication restrictions among the agents. Such communication restrictions make it difficult for agents which try to pursue their own "private" utilities to take actions that also help optimize the world utility. Team formation presents a solution to this problem, where by joining other agents, an agent can significantly increase its knowledge about the environment and improve its chances of both optimizing its own utility and that its doing so will contribute to the world utility. In this article we show how utilities that have been previously shown to be effective in collectives can be modified to be more effective in domains with moderate communication restrictions resulting in performance improvements of up to 75%. Additionally we show that even severe communication constraints can be overcome by forming teams where each agent of a team shares the same utility, increasing performance an additional 25%. We show that utilities and team sizes can be manipulated to form the best compromise between how "aligned" an agent s utility is with the world utility and how easily an agent can learn that utility.

  20. Restriction endonucleases digesting DNA in PCR buffer

    Institute of Scientific and Technical Information of China (English)

    LIU Xue-dong; ZHENG Dong; ZHOU Yan-na; MAO Wei-wei; MA Jian-zhang

    2005-01-01

    Six commonly used restriction endonucleases (Res) (Acc I, Ban II, EcoR I, Hind III, Sac I, Sca I) were tested for their ability to directly digest DNA completely in the Polymerase Chain Reaction (PCR) buffers. The results showed that: with the requirement for additional magnesium supplemented as activator, Res, except EcoR I appeared star activity, completely digested unmethylated lambda DNA after overnight incubation in PCR buffer and functioned as equally well as in recommended Restriction Enzyme Buffer provided with each enzyme; all Res tested completely digested PCR products in PCR buffer, it implied digestion of PCR products may often be performed directly in the PCR tube without the requirement for any precipitation or purification steps; and the concentration of MgCl2 from 2.5 mmol·L-1 to 10 mmol·L-1 did not significantly affect activity of Res in PCR buffer. This simplified method for RE digestion of PCR products could have applications in restriction fragment length polymorphism (RFLP) analysis and single-stranded conformational polymorphism (SSCP) analysis of large PCR products. However, usage of this procedure for cloning applications needs further data.

  1. Emergency building temperature restrictions. Final evaluation

    Energy Technology Data Exchange (ETDEWEB)

    None

    1980-11-01

    On July 5, 1979, DOE promulgated final regulations of the Emergency Building Temperature Restrictions program, placing emergency restrictions on thermostat settings for space heating, space cooling, and hot water in commercial, industrial, and nonresidential public buildings. The final regulations restricted space heating to a maximum of 65/sup 0/F, hot water temperature to a maximum of 105/sup 0/F, and cooling temperature to a minimum of 78/sup 0/F. A comprehensive evaluation of the entire EBTF program for a nine-month period from July 16, 1979 is presented. In Chapter 1, an estimate of the population of buildings covered by EBTR is presented. In Chapter 2, EBTR compliance by building type and region is reported. Exemptions are also discussed. In Chapter 3, the simulations of building energy use are explained and the relative impact of various building characteristics and effectiveness of different control strategies are estimated. Finally, in Chapter 4, the methodology for scaling the individual building energy savings to the national level is described, and estimated national energy savings are presented.

  2. Food restriction modifies ultrastructure of hippocampal synapses.

    Science.gov (United States)

    Babits, Réka; Szőke, Balázs; Sótonyi, Péter; Rácz, Bence

    2016-04-01

    Consumption of high-energy diets may compromise health and may also impair cognition; these impairments have been linked to tasks that require hippocampal function. Conversely, food restriction has been shown to improve certain aspects of hippocampal function, including spatial memory and memory persistence. These diet-dependent functional changes raise the possibility that the synaptic structure underlying hippocampal function is also affected. To examine how short-term food restriction (FR) alters the synaptic structure of the hippocampus, we used quantitative electron microscopy to analyze the organization of neuropil in the CA1 stratum radiatum of the hippocampus in young rats, consequent to reduced food. While four weeks of FR did not modify the density, size, or shape of postsynaptic spines, the synapses established by these spines were altered, displaying increased mean length, and more frequent perforations of postsynaptic densities. That the number of perforated synapses (believed to be an indicator of synaptic enhancement) increased, and that the CA1 spine population had on average significantly longer PSDs suggests that synaptic efficacy of axospinous synapses also increased in the CA1. Taken together, our ultrastructural data reveal previously unrecognized structural changes at hippocampal synapses as a function of food restriction, supporting a link between metabolic balance and synaptic plasticity.

  3. Classical simulation of restricted quantum computations

    OpenAIRE

    Nebhwani, Mrityunjaya

    2013-01-01

    Treball final de màster oficial fet en col·laboració amb Universitat Autònoma de Barcelona (UAB), Universitat de Barcelona (UB) i Institut de Ciències Fotòniques (ICFO) [ANGLÈS] We study restricted models of measurement-based quantum computation; and we investigate whether their output probability distributions can be sampled from efficiently on a classical computer. We find that even for non-adaptive models of MBQC, if this task were feasible then a major conjecture of computational compl...

  4. Privacy-Preserving Restricted Boltzmann Machine

    Directory of Open Access Journals (Sweden)

    Yu Li

    2014-01-01

    Full Text Available With the arrival of the big data era, it is predicted that distributed data mining will lead to an information technology revolution. To motivate different institutes to collaborate with each other, the crucial issue is to eliminate their concerns regarding data privacy. In this paper, we propose a privacy-preserving method for training a restricted boltzmann machine (RBM. The RBM can be got without revealing their private data to each other when using our privacy-preserving method. We provide a correctness and efficiency analysis of our algorithms. The comparative experiment shows that the accuracy is very close to the original RBM model.

  5. Privacy-preserving restricted boltzmann machine.

    Science.gov (United States)

    Li, Yu; Zhang, Yuan; Ji, Yue

    2014-01-01

    With the arrival of the big data era, it is predicted that distributed data mining will lead to an information technology revolution. To motivate different institutes to collaborate with each other, the crucial issue is to eliminate their concerns regarding data privacy. In this paper, we propose a privacy-preserving method for training a restricted boltzmann machine (RBM). The RBM can be got without revealing their private data to each other when using our privacy-preserving method. We provide a correctness and efficiency analysis of our algorithms. The comparative experiment shows that the accuracy is very close to the original RBM model. PMID:25101139

  6. Restricted fish feeding reduces cod otolith opacity

    DEFF Research Database (Denmark)

    Høie, H.; Folkvord, A.; Mosegaard, Henrik;

    2008-01-01

    The purpose of this work was to examine the effect of reduced feeding and constant temperature on cod otolith opacity. Three groups of juvenile cod were given restricted food rations at different times for 4 months, resulting in depressed somatic growth. Otolith opacity was measured on pictures...... in otolith opacity were found between individual fish both within groups and between groups. In two of the three groups significantly more translucent otolith material was deposited in response to reduced feeding. Our results show that variations in feeding and hence fish growth resulted in variation...

  7. The Monetary Policy – Restrictive or Expansive?

    Directory of Open Access Journals (Sweden)

    Adam Szafarczyk

    2007-10-01

    Full Text Available The monetary policy plays an important role in macroeconomic policy of government. There is a question concerning type of this policy expansive or restrictive (easy or tidy monetary policy. Unfortunately, we have a lot of criteria. Each of them gives us other answer. So due to equitation of Irving Fisher we have dominantly expansive monetary policy. This same situation exists when we use nominal value of rediscount interest rate of central bank. Opposite result appears when we use real value of this interest rate or level of obligatory reserve. Taking under consideration liquidity on money market we know, that level of interest rate is too high.

  8. Optimal Policy under Restricted Government Spending

    DEFF Research Database (Denmark)

    Sørensen, Anders

    2006-01-01

    Welfare ranking of policy instruments is addressed in a two-sector Ramsey model with monopoly pricing in one sector as the only distortion. When government spending is restricted, i.e. when a government is unable or unwilling to finance the required costs for implementing the optimum policy...... effectiveness canexceed the welfare loss from introducing new distortions. Moreover, it is found that the investment subsidy is gradually phased out of the welfare maximizing policy, which may be a policy combining the two subsidies, when the level of government spending is increased.Keywords: welfare ranking...

  9. 77 FR 24760 - Safety Advisory 2012-02; Restricted Speed

    Science.gov (United States)

    2012-04-25

    ... Federal Railroad Administration Safety Advisory 2012-02; Restricted Speed AGENCY: Federal Railroad... speed. This safety advisory contains a preliminary discussion of recent train accidents involving a failure to operate at restricted speed and makes recommendations to railroads to ensure...

  10. Medical Expenditure Panel Survey (MEPS) Restricted Data Files

    Data.gov (United States)

    U.S. Department of Health & Human Services — Restricted Data Files Available at the Data Centers Researchers and users with approved research projects can access restricted data files that have not been...

  11. Repletion of TNFα or leptin in calorically restricted mice suppresses post-restriction hyperphagia

    Science.gov (United States)

    Hambly, Catherine; Duncan, Jacqueline S.; Archer, Zoë A.; Moar, Kim M.; Mercer, Julian G.; Speakman, John R.

    2012-01-01

    SUMMARY The causes of post-restriction hyperphagia (PRH) represent a target for drug-based therapies to prevent obesity. However, the factors causing PRH are poorly understood. We show that, in mice, the extent of PRH was independent of the time under restriction, but depended on its severity, suggesting that PRH was driven by signals from altered body composition. Signals related to fat mass were important drivers. Circulating levels of leptin and TNFα were significantly depleted following caloric restriction (CR). We experimentally repleted their levels to match those of controls, and found that in both treatment groups the level of PRH was significantly blunted. These data establish a role for TNFα and leptin in the non-pathological regulation of energy homeostasis. Signals from adipose tissue, including but not limited to leptin and TNFα, regulate PRH and might be targets for therapies that support people engaged in CR to reduce obesity. PMID:21954068

  12. Respiratory Conditions Update: Restrictive Lung Disease.

    Science.gov (United States)

    Robinson, H Coleman

    2016-09-01

    Restrictive lung diseases are a heterogeneous group of conditions characterized by a restrictive pattern on spirometry and confirmed by a reduction in total lung volume. Patients with more severe symptoms may have a reduced diffusing capacity of the lung for carbon monoxide. Etiologies can be intrinsic with lung parenchymal involvement, as in interstitial lung diseases, or extrinsic to the lung, as in obesity and neuromuscular disorders. Idiopathic pulmonary fibrosis is a chronic progressive interstitial pneumonia with fibrosis for which treatment is primarily supportive with oxygen therapy, pulmonary rehabilitation, and management of comorbid conditions. Newer drugs for idiopathic pulmonary fibrosis, such as pirfenidone and nintedanib, can slow disease progression. Referral for evaluation for lung transplantation is recommended for appropriate patients. Obstructive sleep apnea and obesity hypoventilation syndrome increasingly are common health issues, with symptoms that can include snoring, daytime somnolence, difficulty concentrating, fatigue, witnessed apneas, and morning headaches. Serum bicarbonate may serve as a biomarker in screening for subclinical obesity hypoventilation syndrome. Preoperative evaluations should assess pulmonary risk in addition to cardiac risk with a thorough history, laboratory tests, and functional capacity assessments. Optimization of management may include weight loss, pulmonary rehabilitation, oxygen therapy, and respiratory support. PMID:27576233

  13. Restrictions on Purely Kinetic K-Essence

    Institute of Scientific and Technical Information of China (English)

    YANG Rong-Jia; QI Jing-Zhao; YANG Bao-Zhu

    2011-01-01

    We restrict purely kinetic k-essence. Assuming that the equation of state is a power law of the kinetic energy, I.e. W = w0Xα, we find that a must be positive to obtain accelerated phases, constrained from the conditions for stability and causality. In this case the k-essence behaves like a phantom. We also study the evolutions of the equation of state and the speed of sound with numerical simulations.%We restrict purely kinetic k-essence.Assuming that the equation of state is a power law of the kinetic energy,i.e.ω =ω0Xα,we find that α must be positive to obtain accelerated phases,constrained from the conditions for stability and causality.In this case the k-essence behaves like a phantom.We also study the evolutions of the equation of state and the speed of sound with numerical simulations.In the last decade a convergence of independent cosmological observations have suggested that the Universe is experiencing accelerated expansion.An unknown energy component,dubbed as dark energy,has been proposed to explain this acceleration.

  14. Columbus Closure Project Released without Radiological Restrictions

    International Nuclear Information System (INIS)

    The Columbus Closure Project (CCP), a historic radiological research complex, was cleaned up for future use without radiological restriction in 2006. The CCP research and development site contributed to national defense, nuclear fuel fabrication, and the development of safe nuclear reactors in the United States until 1988 when research activities were concluded for site decommissioning. In November of 2003, the Ohio Field Office of the U.S. Department of Energy contracted ECC/E2 Closure Services, LLC (Closure Services) to complete the removal of radioactive contamination from of a 1955 era nuclear sciences area consisting of a large hot cell facility, research reactor building and underground piping. The project known as the Columbus Closure Project (CCP) was completed in 27 months and brought to a close 16 years of D and D in Columbus, Ohio. This paper examines the project innovations and challenges presented during the Columbus Closure Project. The examination of the CCP includes the project regulatory environment, the CS safety program, accelerated clean up innovation, project execution strategies and management of project waste issues and the regulatory approach to site release 'without radiological restrictions'. (authors)

  15. 9 CFR 121.13 - Restricted experiments. 10

    Science.gov (United States)

    2010-01-01

    ... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false Restricted experiments. 10 121.13... TRANSFER OF SELECT AGENTS AND TOXINS § 121.13 Restricted experiments. 10 10 For guidance, see the NIH... entity may not conduct a restricted experiment with a VS select agent or toxin unless approved by...

  16. 36 CFR 13.1174 - Whale water restrictions.

    Science.gov (United States)

    2010-07-01

    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Whale water restrictions. 13... Vessel Operating Restrictions § 13.1174 Whale water restrictions. (a) May 15 through September 30, the following waters are designated as whale waters. (1) Waters north of a line drawn from Point Carolus...

  17. 48 CFR 552.203-71 - Restriction on Advertising.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Restriction on Advertising... Restriction on Advertising. As prescribed in 503.570-2, insert the following clause: Restriction on Advertising (SEP 1999) The Contractor shall not refer to this contract in commercial advertising or...

  18. 14 CFR 252.8 - Extent of smoking restrictions.

    Science.gov (United States)

    2010-01-01

    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Extent of smoking restrictions. 252.8... PROCEEDINGS) ECONOMIC REGULATIONS SMOKING ABOARD AIRCRAFT § 252.8 Extent of smoking restrictions. The restrictions on smoking described in §§ 252.3 through 252.7 shall apply to all locations within the aircraft....

  19. 49 CFR 215.303 - Stenciling of restricted cars.

    Science.gov (United States)

    2010-10-01

    ... 49 Transportation 4 2010-10-01 2010-10-01 false Stenciling of restricted cars. 215.303 Section 215... ADMINISTRATION, DEPARTMENT OF TRANSPORTATION RAILROAD FREIGHT CAR SAFETY STANDARDS Stenciling § 215.303 Stenciling of restricted cars. (a) Each restricted railroad freight car that is described in § 215.205(a)...

  20. 20 CFR 332.3 - Mileage and work restrictions.

    Science.gov (United States)

    2010-04-01

    ... INSURANCE ACT MILEAGE OR WORK RESTRICTIONS AND STAND-BY OR LAY-OVER RULES § 332.3 Mileage and work... 20 Employees' Benefits 1 2010-04-01 2010-04-01 false Mileage and work restrictions. 332.3 Section... solely because of the application to him of a mileage or work restriction agreed upon in a...

  1. Oncogenic pathways impinging on the G2-restriction point

    NARCIS (Netherlands)

    Foijer, F; Simonis, M; van Vliet, M; Wessels, L; Kerkhoven, R; Sorger, P K; Te Riele, H

    2008-01-01

    In the absence of mitogenic stimuli, cells normally arrest in G(1/0), because they fail to pass the G1-restriction point. However, abrogation of the G1-restriction point (by loss of the retinoblastoma gene family) reveals a second-restriction point that arrests cells in G2. Serum-starvation-induced

  2. Restricted Edge Connectivity of BinaryUndirected Kautz Graphs

    Institute of Scientific and Technical Information of China (English)

    OUJian-ping

    2004-01-01

    A restricted edge cut is an edge cut of a connected graph whose removal resultsin a disconnected graph without isolated vertices. The size of a minimum restricted edge cutof a graph G is called its restricted edge connectivity, and is denoted by λ′(G). Let ξ(G) bethe minimum edge degree of graph G. It is known that λ′(G) ≤ξ(G) if G contains restrictededge cuts. Graph G is called maximal restricted edge connected if the equality holds in thethe preceding inequality. In this paper, undirected Kautz graph UK(2, n) is proved to bemaximal restricted edge connected if n ≥ 2.

  3. A FORTRAN Program for Correcting Correlation Coefficients for Restriction in Range for Explicit or Implicit Restriction.

    Science.gov (United States)

    Lewis, Mary A.; Boone, James O.

    1979-01-01

    Restriction in range is a measurement problem frequently encountered in research studies that utilize correlation coefficients. A FORTRAN program is described that can compute the estimated unrestricted correlation coefficient in either the explicit or implicit case. The user selects the appropriate formula to be employed from five that are…

  4. Formation reconfiguration in restricted three body problem

    Institute of Scientific and Technical Information of China (English)

    Shengping Gong; Junfeng Li; Hexi Baoyin; Yunfeng Gao

    2007-01-01

    Reconfiguration of formation flying around a halo orbit of the Sun-Earth restricted three body system is investigated with impulse maneuvers. For a short time reconfiguration, the two-impulse maneuver is investigated with both analytical and numerical methods and the BeginningEnding (BE) method is proven to be an energy-optimal one of all two-impulse (TI) reconfigurations, and the energy consumption of BE is independent of the position of the chief spacecraft, and decreases with the reconfiguration time.Then, genetic algorithm is adopted to optimize the energy consumption. The results show that the optimal energy increases with radius difference between the initial and final orbits, and decreases with the reconfiguration time.

  5. Membrane barriers for radon gas flow restrictions

    International Nuclear Information System (INIS)

    Research was performed to assess the feasibility of barrier membrane substances, for use within mining or associated high risk environments, in restricting the diffusion transport of radon gas quantities. Specific tests were conducted to determine permeability parameters of a variety of membrane materials with reference to radon flow capabilities. Tests were conducted both within laboratory and in-situ emanation environments where concentrations and diffusion flows of radon gas were known to exist. Equilibrium radon gas concentrations were monitored in initially radon-free chambers adjacent to gas sources, but separated by specified membrane substances. Membrane barrier effectiveness was demonstrated to result in reduced emanation concentrations of radon gas within the sampling chamber atmosphere. Minimum gas concentrations were evidenced where the barrier membrane material was shown to exhibit lowest radon permeability characteristics

  6. Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance.

    Science.gov (United States)

    Pietrocola, Federico; Pol, Jonathan; Vacchelli, Erika; Rao, Shuan; Enot, David P; Baracco, Elisa E; Levesque, Sarah; Castoldi, Francesca; Jacquelot, Nicolas; Yamazaki, Takahiro; Senovilla, Laura; Marino, Guillermo; Aranda, Fernando; Durand, Sylvère; Sica, Valentina; Chery, Alexis; Lachkar, Sylvie; Sigl, Verena; Bloy, Norma; Buque, Aitziber; Falzoni, Simonetta; Ryffel, Bernhard; Apetoh, Lionel; Di Virgilio, Francesco; Madeo, Frank; Maiuri, Maria Chiara; Zitvogel, Laurence; Levine, Beth; Penninger, Josef M; Kroemer, Guido

    2016-07-11

    Caloric restriction mimetics (CRMs) mimic the biochemical effects of nutrient deprivation by reducing lysine acetylation of cellular proteins, thus triggering autophagy. Treatment with the CRM hydroxycitrate, an inhibitor of ATP citrate lyase, induced the depletion of regulatory T cells (which dampen anticancer immunity) from autophagy-competent, but not autophagy-deficient, mutant KRAS-induced lung cancers in mice, thereby improving anticancer immunosurveillance and reducing tumor mass. Short-term fasting or treatment with several chemically unrelated autophagy-inducing CRMs, including hydroxycitrate and spermidine, improved the inhibition of tumor growth by chemotherapy in vivo. This effect was only observed for autophagy-competent tumors, depended on the presence of T lymphocytes, and was accompanied by the depletion of regulatory T cells from the tumor bed. PMID:27411589

  7. Constrictive Pericarditis Versus Restrictive Cardiomyopathy?

    Science.gov (United States)

    Garcia, Mario J

    2016-05-01

    About one-half of the patients with congestive heart failure have preserved left ventricular ejection fraction (HFpEF). Although the etiology of HFpEF is most commonly related to long-standing hypertension and atherosclerosis, a significant number of suspected HFpEF patients have a restrictive cardiomyopathy or chronic pericardial disease. Recognizing these syndromes is important because early diagnosis may lead to instituting specific therapy that may prolong survival, improve quality of life, and/or recognize and treat an underlying systemic disorder. Advances in diagnostic imaging, biomarkers, and genetic testing today allow identification of the specific etiology in most cases. Novel pharmacological, immunologic, and surgical therapies are leading to improved quality of life and survival.

  8. Restriction modification systems as engines of diversity.

    Science.gov (United States)

    Sneppen, Kim; Semsey, Szabolcs; Seshasayee, Aswin S N; Krishna, Sandeep

    2015-01-01

    Restriction modification (RM) systems provide protection against a broad spectrum of phages. However, the likelihood of a phage permanently bypassing this can be as high as 0.1 per infection (Korona et al., 1993) which makes for a relatively weak defense. Here we argue that, apart from providing such transient defenses, RM systems can facilitate long-term coexistence of many bacterial strains. We show that this diversity can be as large as the burst size of the phage but no larger-a curious correspondence between a number at the level of species and another number at the level of individuals. Such a highly diverse and stably coexisting ecosystem is robust to substantial variation in both bacterial growth rates and strength of their RM systems, which might be one reason why quite weak RM systems exist in the wild. PMID:26082758

  9. Restriction Modification Systems as Engines of Diversity

    Directory of Open Access Journals (Sweden)

    Kim eSneppen

    2015-06-01

    Full Text Available Restriction modification (RM systems provide protection against a broad spectrum of phages. However, the likelihood of a phage permanently bypassing this can be as high as 0.1 per infection (Korona et al., J. Gen. Microbiol. 139: 1283-1290, 1993 which makes for a relatively weak defence. Here we argue that, apart from providing such transient defences, RM systems can facilitate long-term coexistence of many bacterial strains. We show that this diversity can be as large as the burst size of the phage but no larger -- a curious correspondence between a number at the level of species and another number at the level of individuals. Such a highly diverse and stably coexisting ecosystem is robust to substantial variation in both bacterial growth rates and strength of their RM systems, which might be one reason why quite weak RM systems exist in the wild.

  10. Epitaxial growth by monolayer restricted galvanic displacement

    Directory of Open Access Journals (Sweden)

    Vasilić Rastko

    2012-01-01

    Full Text Available The development of a new method for epitaxial growth of metals in solution by galvanic displacement of layers pre-deposited by underpotential deposition (UPD was discussed and experimentally illustrated throughout the lecture. Cyclic voltammetry (CV and scanning tunneling microscopy (STM are employed to carry out and monitor a “quasi-perfect”, two-dimensional growth of Ag on Au(111, Cu on Ag(111, and Cu on Au(111 by repetitive galvanic displacement of underpotentially deposited monolayers. A comparative study emphasizes the displacement stoichiometry as an efficient tool for thickness control during the deposition process and as a key parameter that affects the deposit morphology. The excellent quality of layers deposited by monolayer-restricted galvanic displacement is manifested by a steady UPD voltammetry and ascertained by a flat and uniform surface morphology maintained during the entire growth process.

  11. Autotagging music with conditional restricted Boltzmann machines

    CERN Document Server

    Mandel, Michael; Larochelle, Hugo; Bengio, Yoshua

    2011-01-01

    This paper describes two applications of conditional restricted Boltzmann machines (CRBMs) to the task of autotagging music. The first consists of training a CRBM to predict tags that a user would apply to a clip of a song based on tags already applied by other users. By learning the relationships between tags, this model is able to pre-process training data to significantly improve the performance of a support vector machine (SVM) autotagging. The second is the use of a discriminative RBM, a type of CRBM, to autotag music. By simultaneously exploiting the relationships among tags and between tags and audio-based features, this model is able to significantly outperform SVMs, logistic regression, and multi-layer perceptrons. In order to be applied to this problem, the discriminative RBM was generalized to the multi-label setting and four different learning algorithms for it were evaluated, the first such in-depth analysis of which we are aware.

  12. AGORA: Assembly Guided by Optical Restriction Alignment

    Directory of Open Access Journals (Sweden)

    Lin Henry C

    2012-08-01

    Full Text Available Abstract Background Genome assembly is difficult due to repeated sequences within the genome, which create ambiguities and cause the final assembly to be broken up into many separate sequences (contigs. Long range linking information, such as mate-pairs or mapping data, is necessary to help assembly software resolve repeats, thereby leading to a more complete reconstruction of genomes. Prior work has used optical maps for validating assemblies and scaffolding contigs, after an initial assembly has been produced. However, optical maps have not previously been used within the genome assembly process. Here, we use optical map information within the popular de Bruijn graph assembly paradigm to eliminate paths in the de Bruijn graph which are not consistent with the optical map and help determine the correct reconstruction of the genome. Results We developed a new algorithm called AGORA: Assembly Guided by Optical Restriction Alignment. AGORA is the first algorithm to use optical map information directly within the de Bruijn graph framework to help produce an accurate assembly of a genome that is consistent with the optical map information provided. Our simulations on bacterial genomes show that AGORA is effective at producing assemblies closely matching the reference sequences. Additionally, we show that noise in the optical map can have a strong impact on the final assembly quality for some complex genomes, and we also measure how various characteristics of the starting de Bruijn graph may impact the quality of the final assembly. Lastly, we show that a proper choice of restriction enzyme for the optical map may substantially improve the quality of the final assembly. Conclusions Our work shows that optical maps can be used effectively to assemble genomes within the de Bruijn graph assembly framework. Our experiments also provide insights into the characteristics of the mapping data that most affect the performance of our algorithm, indicating the

  13. Creating Simple Admin Tools Using Info*Engine and Java

    Science.gov (United States)

    Jones, Corey; Kapatos, Dennis; Skradski, Cory; Felkins, J. D.

    2012-01-01

    PTC has provided a simple way to dynamically interact with Windchill using Info*Engine. This presentation will describe how to create a simple Info*Engine Tasks capable of saving Windchill 10.0 administration of tedious work.

  14. MySQL Admin Cookbook LITE Replication and Indexing

    CERN Document Server

    Schneller, Daniel

    2011-01-01

    This cookbook presents solutions to problems in the form of recipes. Each recipe provides the reader with easy step-by-step descriptions of the actions necessary to accomplish a specific task. Example values and code samples are used throughout the recipes, which makes adaptation for individual needs easy. This book is for ambitious MySQL users as well as professional data center database administrators. Beginners as well as experienced administrators will benefit from this cookbook and get fresh ideas to improve their MySQL environments. Detailed background information will enable them to wid

  15. Restriction of bacteriophage plaque formation in Streptomyces spp.

    Science.gov (United States)

    Cox, K L; Baltz, R H

    1984-08-01

    Several Streptomyces species that produce restriction endonucleases were characterized for their ability to propagate 10 different broad host range bacteriophages. Each species displayed a different pattern of plaque formation. A restrictionless mutant of S. albus G allowed plaque formation by all 10 phages, whereas the wild-type strain showed plaques with only 2 phages. DNA isolated from three of the phages was analyzed for the presence of restriction sites for Streptomyces species-encoded enzymes, and a very strong correlation was established between the failure to form plaques on Streptomyces species that produced particular restriction enzymes and the presence of the corresponding restriction sites in the phage DNA. Also, the phages that lacked restriction sites in their DNA generally formed plaques on the corresponding restriction endonuclease-producing hosts at high efficiency. The DNAs from the three phages analyzed also generally contained either many or no restriction sites for the Streptomyces species-produced enzymes, suggesting a strong evolutionary trend to either eliminate all or tolerate many restriction sites. The data indicate that restriction plays a major role in host range determination for Streptomyces phages. Analysis of bacteriophage host ranges of many other uncharacterized Streptomyces hosts has identified four relatively nonrestricting hosts, at least two of which may be suitable hosts for gene cloning. The data also suggest that several restriction systems remain to be identified in the genus Streptomyces.

  16. Calorie restriction and methionine restriction in control of endogenous hydrogen sulfide production by the transsulfuration pathway.

    Science.gov (United States)

    Hine, Christopher; Mitchell, James R

    2015-08-01

    H2S is a gas easily identified by its distinctive odor. Although environmental exposure to H2S has been viewed alternately as therapeutic or toxic through the centuries, H2S has recently regained recognition for its numerous beneficial biological effects. Most experiments documenting such benefits, including improved glucose tolerance, increased stress resistance, and even lifespan extension, are based on exposure of experimental organisms to exogenous sources of H2S. However, appreciation is growing for the importance of H2S produced endogenously by the evolutionary conserved transsulfuration pathway (TSP) in health and longevity. Recent data implicate H2S produced by the TSP in pleiotropic benefits of dietary restriction (DR), or reduced nutrient/energy intake without malnutrition. DR, best known as the most reliable way to extend lifespan in a wide range of experimental organisms, includes various regimens aimed at either reducing overall calorie intake (calorie restriction, intermittent/every-other-day fasting) or reducing particular nutrients such as protein or the essential amino acid, methionine (methionine restriction), with overlapping functional benefits on stress resistance, metabolic fitness and lifespan. Here we will review the small but growing body of literature linking the TSP to the functional benefits of DR in part through the production of endogenous H2S, with an emphasis on regulation of the TSP and H2S production by diet and mechanisms of beneficial H2S action.

  17. Calorie restriction and methionine restriction in control of endogenous hydrogen sulfide production by the transsulfuration pathway.

    Science.gov (United States)

    Hine, Christopher; Mitchell, James R

    2015-08-01

    H2S is a gas easily identified by its distinctive odor. Although environmental exposure to H2S has been viewed alternately as therapeutic or toxic through the centuries, H2S has recently regained recognition for its numerous beneficial biological effects. Most experiments documenting such benefits, including improved glucose tolerance, increased stress resistance, and even lifespan extension, are based on exposure of experimental organisms to exogenous sources of H2S. However, appreciation is growing for the importance of H2S produced endogenously by the evolutionary conserved transsulfuration pathway (TSP) in health and longevity. Recent data implicate H2S produced by the TSP in pleiotropic benefits of dietary restriction (DR), or reduced nutrient/energy intake without malnutrition. DR, best known as the most reliable way to extend lifespan in a wide range of experimental organisms, includes various regimens aimed at either reducing overall calorie intake (calorie restriction, intermittent/every-other-day fasting) or reducing particular nutrients such as protein or the essential amino acid, methionine (methionine restriction), with overlapping functional benefits on stress resistance, metabolic fitness and lifespan. Here we will review the small but growing body of literature linking the TSP to the functional benefits of DR in part through the production of endogenous H2S, with an emphasis on regulation of the TSP and H2S production by diet and mechanisms of beneficial H2S action. PMID:25523462

  18. Blood Flow Restricted Exercise and Vascular Function

    Directory of Open Access Journals (Sweden)

    Masahiro Horiuchi

    2012-01-01

    Full Text Available It is established that regular aerobic training improves vascular function, for example, endothelium-dependent vasodilatation and arterial stiffness or compliance and thereby constitutes a preventative measure against cardiovascular disease. In contrast, high-intensity resistance training impairs vascular function, while the influence of moderate-intensity resistance training on vascular function is still controversial. However, aerobic training is insufficient to inhibit loss in muscular strength with advancing age; thus, resistance training is recommended to prevent sarcopenia. Recently, several lines of study have provided compelling data showing that exercise and training with blood flow restriction (BFR leads to muscle hypertrophy and strength increase. As such, BFR training might be a novel means of overcoming the contradiction between aerobic and high-intensity resistance training. Although it is not enough evidence to obtain consensus about impact of BFR training on vascular function, available evidences suggested that BFR training did not change coagulation factors and arterial compliance though with inconsistence results in endothelial function. This paper is a review of the literature on the impact of BFR exercise and training on vascular function, such as endothelial function, arterial compliance, or other potential factors in comparison with those of aerobic and resistance training.

  19. Near BPS Skyrmions and Restricted Harmonic Maps

    CERN Document Server

    Speight, J M

    2014-01-01

    Motivated by a class of near BPS Skyrme models introduced by Adam, S\\'anchez-Guill\\'en and Wereszczy\\'nski, the following variant of the harmonic map problem is introduced: a map $\\phi:(M,g)\\rightarrow (N,h)$ between Riemannian manifolds is restricted harmonic (RH) if it locally extremizes $E_2$ on its $SDiff(M)$ orbit, where $SDiff(M)$ denotes the group of volume preserving diffeomorphisms of $(M,g)$, and $E_2$ denotes the Dirichlet energy. It is conjectured that near BPS skyrmions tend to RH maps in the BPS limit. It is shown that $\\phi$ is RH if and only if $\\phi^*h$ has exact divergence, and a linear stability theory of RH maps is developed, whence it follows that all weakly conformal maps, for example, are stable RH. Examples of RH maps in every degree class $R^3\\to SU(2)$ and $R^2\\to S^2$ are constructed. It is shown that the axially symmetric BPS skyrmions on which all previous analytic studies of near BPS Skyrme models have been based, are not RH, so each such field can be deformed along $SDiff(R^3)$ ...

  20. Methionine restriction beyond life-span extension.

    Science.gov (United States)

    Ables, Gene P; Hens, Julie R; Nichenametla, Sailendra N

    2016-01-01

    Dietary methionine restriction (MR) extends life span across species via various intracellular regulatory mechanisms. In rodents, MR induces resistance against adiposity, improves hepatic glucose metabolism, preserves cardiac function, and reduces body size, all of which can affect the onset of age-related diseases. Recent studies have shown that MR-affected biomarkers, such as fibroblast growth factor 21, adiponectin, leptin, cystathionine β synthase, and insulin-like growth factor 1, can potentially alter physiology. The beneficial effects of MR could be explained in part by its ability to reduce mitochondrial oxidative stress. Studies have revealed that MR can reduce reactive oxygen species that damage cells and promote cancer progression. It has been demonstrated that either MR or the targeting of specific genes in the methionine cycle could induce cell apoptosis while decreasing proliferation in several cancer models. The complete mechanism underlying the actions of MR on the cell cycle during cancer has not been fully elucidated. Epigenetic mechanisms, such as methylation and noncoding RNAs, are also possible downstream effectors of MR; future studies should help to elucidate some of these mechanisms. Despite evidence that changes in dietary methionine can affect epigenetics, it remains unknown whether epigenetics is a mechanism in MR. This review summarizes research on MR and its involvement in metabolism, cancer, and epigenetics.

  1. Second law of thermodynamics under control restrictions.

    Science.gov (United States)

    Wilming, H; Gallego, R; Eisert, J

    2016-04-01

    The second law of thermodynamics, formulated as an ultimate bound on the maximum extractable work, has been rigorously derived in multiple scenarios. However, the unavoidable limitations that emerge due to the lack of control on small systems are often disregarded when deriving such bounds, which is specifically important in the context of quantum thermodynamics. Here we study the maximum extractable work with limited control over the working system and its interaction with the heat bath. We derive a general second law when the set of accessible Hamiltonians of the working system is arbitrarily restricted. We then apply our bound to particular scenarios that are important in realistic implementations: limitations on the maximum energy gap and local control over many-body systems. We hence demonstrate in what precise way the lack of control affects the second law. In particular, contrary to the unrestricted case, we show that the optimal work extraction is not achieved by simple thermal contacts. Our results not only generalize the second law to scenarios of practical relevance, but also take first steps in the direction of local thermodynamics. PMID:27176273

  2. Maternal dietary restriction alters offspring's sleep homeostasis.

    Directory of Open Access Journals (Sweden)

    Noriyuki Shimizu

    Full Text Available Nutritional state in the gestation period influences fetal growth and development. We hypothesized that undernutrition during gestation would affect offspring sleep architecture and/or homeostasis. Pregnant female mice were assigned to either control (fed ad libitum; AD or 50% dietary restriction (DR groups from gestation day 12 to parturition. After parturition, dams were fed AD chow. After weaning, the pups were also fed AD into adulthood. At adulthood (aged 8-9 weeks, we carried out sleep recordings. Although offspring mice displayed a significantly reduced body weight at birth, their weights recovered three days after birth. Enhancement of electroencephalogram (EEG slow wave activity (SWA during non-rapid eye movement (NREM sleep was observed in the DR mice over a 24-hour period without changing the diurnal pattern or amounts of wake, NREM, or rapid eye movement (REM sleep. In addition, DR mice also displayed an enhancement of EEG-SWA rebound after a 6-hour sleep deprivation and a higher threshold for waking in the face of external stimuli. DR adult offspring mice exhibited small but significant increases in the expression of hypothalamic peroxisome proliferator-activated receptor α (Pparα and brain-specific carnitine palmitoyltransferase 1 (Cpt1c mRNA, two genes involved in lipid metabolism. Undernutrition during pregnancy may influence sleep homeostasis, with offspring exhibiting greater sleep pressure.

  3. Intrauterine Growth Restriction: Antenatal and Postnatal Aspects

    Science.gov (United States)

    Sharma, Deepak; Shastri, Sweta; Sharma, Pradeep

    2016-01-01

    Intrauterine growth restriction (IUGR), a condition that occurs due to various reasons, is an important cause of fetal and neonatal morbidity and mortality. It has been defined as a rate of fetal growth that is less than normal in light of the growth potential of that specific infant. Usually, IUGR and small for gestational age (SGA) are used interchangeably in literature, even though there exist minute differences between them. SGA has been defined as having birth weight less than two standard deviations below the mean or less than the 10th percentile of a population-specific birth weight for specific gestational age. These infants have many acute neonatal problems that include perinatal asphyxia, hypothermia, hypoglycemia, and polycythemia. The likely long-term complications that are prone to develop when IUGR infants grow up includes growth retardation, major and subtle neurodevelopmental handicaps, and developmental origin of health and disease. In this review, we have covered various antenatal and postnatal aspects of IUGR. PMID:27441006

  4. What you should know about restrictive covenants in health care.

    Science.gov (United States)

    Austin, Michael G; Grosack, Matthew

    2013-01-01

    In recent years, many states have shown a greater inclination to enforce restrictive covenant provisions in contracts involving healthcare organizations and their employees, physicians, or other contacting parties. In general, an enforceable restrictive covenant is one that is deemed to have been reasonably drafted to do no more than to protect the company's legitimate business interest. Key areas of concern in health care that often fall under the protection of restrictive covenants include patient referral sources and relationships with patients. PMID:23360060

  5. How restriction enzymes became the workhorses of molecular biology

    OpenAIRE

    Roberts, Richard J.

    2005-01-01

    Restriction enzymes have proved to be invaluable for the physical mapping of DNA. They offer unparalleled opportunities for diagnosing DNA sequence content and are used in fields as disparate as criminal forensics and basic research. In fact, without restriction enzymes, the biotechnology industry would certainly not have flourished as it has. The first experiments demonstrating the utility of restriction enzymes were carried out by Danna and Nathans and reported in 1971. This pioneering stud...

  6. Earth system multi-body restriction dynamics model research

    Institute of Scientific and Technical Information of China (English)

    ZHANG Qingxian; BI Siwen; GONG Huili

    2006-01-01

    Research provides a theoretical basis for an Earth system multi-body mechanics model and its dynamics, including the Earth system multi-body restriction function and its power, Earth system multi-body restriction under decreasing generalized velocity and decreasing partial palstance, the Earth system multi-body decreasing generalized force, a moving mechanics function, and the Earth system multi-body restriction's wattful and wattless forces.

  7. Health promotion by dietary restriction--a focus.

    Science.gov (United States)

    Ramkumar, K M

    2006-01-01

    Food restriction, although long popular among gerontologists, has emerged as a new challenge in public health in postindustrial societies because this is the only intervention that repeatedly and strikingly increases maximum life span. The practice of food restriction is widespread for cosmetic, health, and economic reasons. The beneficial effects and the molecular mechanism of food restriction have been well established. The present review summarizes the rapidly accumulating evidence on the involvement of food restriction in various diseases and focuses on good dietary practices for health promotion in modern life style. PMID:16910315

  8. Crowding during restricted and free viewing.

    Science.gov (United States)

    Wallace, Julian M; Chiu, Michael K; Nandy, Anirvan S; Tjan, Bosco S

    2013-05-24

    Crowding impairs the perception of form in peripheral vision. It is likely to be a key limiting factor of form vision in patients without central vision. Crowding has been extensively studied in normally sighted individuals, typically with a stimulus duration of a few hundred milliseconds to avoid eye movements. These restricted testing conditions do not reflect the natural behavior of a patient with central field loss. Could unlimited stimulus duration and unrestricted eye movements change the properties of crowding in any fundamental way? We studied letter identification in the peripheral vision of normally sighted observers in three conditions: (i) a fixation condition with a brief stimulus presentation of 250 ms, (ii) another fixation condition but with an unlimited viewing time, and (iii) an unrestricted eye movement condition with an artificial central scotoma and an unlimited viewing time. In all conditions, contrast thresholds were measured as a function of target-to-flanker spacing, from which we estimated the spatial extent of crowding in terms of critical spacing. We found that presentation duration beyond 250 ms had little effect on critical spacing with stable gaze. With unrestricted eye movements and a simulated central scotoma, we found a large variability in critical spacing across observers, but more importantly, the variability in critical spacing was well correlated with the variability in target eccentricity. Our results assure that the large body of findings on crowding made with briefly presented stimuli remains relevant to conditions where viewing time is unconstrained. Our results further suggest that impaired oculomotor control associated with central vision loss can confound peripheral form vision beyond the limits imposed by crowding.

  9. Comparison of a Restricted and Unrestricted Vegan Diet Plan with a Restricted Omnivorous Diet Plan on Health-Specific Measures

    OpenAIRE

    Bloomer, Richard J; Gunnels, Trint A; JohnHenry M. Schriefer

    2015-01-01

    Background: We have previously noted beneficial health outcomes when individuals follow a dietary restriction plan in accordance with the Daniel Fast (DF). This is true whether individuals eliminate all animal products or include small amounts of meat and dairy in their plan. The present study sought to compare anthropometric and biochemical measures of health in individuals following a traditional DF (i.e., restricted vegan) or modified DF (i.e., restricted omnivorous; inclusive of ad libitu...

  10. 7 CFR 331.13 - Restricted experiments. 5

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Restricted experiments. 5 331.13 Section 331.13... Restricted experiments. 5 5 For guidance, see the NIH publication, “NIH Guidelines for Research Involving.../ag_selectagent/index.html. (a) An individual or entity may not conduct the following...

  11. The challenge of cost restrictions in smile design.

    Science.gov (United States)

    Feigenbaum, N

    1991-09-01

    This article demonstrates a method for smile enhancement involving the familiar "gummy" smile as well as irregular incisor gingival emergence levels. In this case study, financial considerations limited a comprehensive restorative treatment plan, restricting changes to several anterior teeth. Despite the restrictions, a solution was found.

  12. 29 CFR 530.2 - Restriction of homework.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Restriction of homework. 530.2 Section 530.2 Labor... OF HOMEWORKERS IN CERTAIN INDUSTRIES General § 530.2 Restriction of homework. Except as provided in... special homework certificate issued and in effect pursuant to this part has been obtained for...

  13. 48 CFR 1403.570 - Restrictions on contractor advertising.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Restrictions on contractor advertising. 1403.570 Section 1403.570 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR... 1403.570 Restrictions on contractor advertising....

  14. 32 CFR 516.5 - Restriction on contact with DOJ.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Restriction on contact with DOJ. 516.5 Section 516.5 National Defense Department of Defense (Continued) DEPARTMENT OF THE ARMY AID OF CIVIL AUTHORITIES AND PUBLIC RELATIONS LITIGATION General § 516.5 Restriction on contact with DOJ. (a) General...

  15. 34 CFR 76.566 - Fixed costs-restricted rate.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Fixed costs-restricted rate. 76.566 Section 76.566 Education Office of the Secretary, Department of Education STATE-ADMINISTERED PROGRAMS What Conditions Must Be Met by the State and Its Subgrantees? Indirect Cost Rates § 76.566 Fixed costs—restricted rate....

  16. Reduced Automatic Motivational Orientation Towards Food in Restricting Anorexia Nervosa

    NARCIS (Netherlands)

    Veenstra, Esther M.; de Jong, Peter J.

    2011-01-01

    A striking and characteristic feature of the restricting subtype of anorexia nervosa (AN) is that they are extremely successful in regulating their food intake in a destructive manner. A possible explanation for the persistent character of their restricted food intake could be a loss of the motivati

  17. Reverse triple I method of restriction for fuzzy reasoning

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    A theory of reverse triple I method of restriction for implication operator R0 is proposed.And the general computation formulas of infimum for fuzzy modus ponens and supremum for fuzzy modus tollens of a-reverse triple I method of restriction are obtained respectively.

  18. 7 CFR 319.75-2 - Restricted articles. 1

    Science.gov (United States)

    2010-01-01

    ... other provisions of 7 CFR part 319. For example, fresh whole chilies (Capsicum spp.) and fresh whole red... be subject to additional restrictions under the provisions in 7 CFR 319.8 et seq. (6) Used jute or... 7 Agriculture 5 2010-01-01 2010-01-01 false Restricted articles. 1 319.75-2 Section...

  19. 40 CFR 152.175 - Pesticides classified for restricted use.

    Science.gov (United States)

    2010-07-01

    ... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Pesticides classified for restricted...) PESTICIDE PROGRAMS PESTICIDE REGISTRATION AND CLASSIFICATION PROCEDURES Classification of Pesticides § 152.175 Pesticides classified for restricted use. The following uses of pesticide products containing...

  20. Consequences of intrauterine growth restriction for the kidney

    NARCIS (Netherlands)

    M.F. Schreuder; A. van Wijk (Ans); H.A. Delemarre-van de Waal (Henriette)

    2006-01-01

    textabstractLow birth weight due to intrauterine growth restriction is associated with various diseases in adulthood, such as hypertension, cardiovascular disease, insulin resistance and end-stage renal disease. The purpose of this review is to describe the effects of intrauterine growth restriction

  1. Effect of feed restriction on performance of growing rabbits

    Directory of Open Access Journals (Sweden)

    Maria Cristina de Oliveira

    2012-06-01

    Full Text Available This experiment assessed the effect of feed restriction in rabbits on performance and economic viability of the activity. Sixty New Zealand White rabbits, weaned at 33 days and slaughtered at 81 days of age, were used. The design was of randomized blocks with four treatments and five replications. The treatments were, as follows: 1 - free feeding, 2 - feed restriction from 35 to 40 days of age (50 g/d/rabbit, 3 - feed restriction from 54 to 61 days of age (90 g/d/rabbit and 4 - feed restriction from 33 to 40 days (50 g/d/rabbit and from 54 to 61 days of age (90 g/d/rabbit. There was no difference in the performance and carcass parameters, indicating that there was compensatory growth in the rabbits that suffered feed restriction. The best gross margin was obtained with feed restriction from 54 to 61 days age. Feed restriction in growing rabbits can be adopted at different ages because it does not interfere negatively in the performance and carcass parameters. In two periods and from 51 to 61 days, feed restriction was more economically viable for the sale of live and slaughtered rabbits, respectively.

  2. 7 CFR 800.76 - Prohibited services; restricted services.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Prohibited services; restricted services. 800.76..., PACKERS AND STOCKYARD ADMINISTRATION (FEDERAL GRAIN INSPECTION SERVICE), DEPARTMENT OF AGRICULTURE GENERAL REGULATIONS Kinds of Official Services § 800.76 Prohibited services; restricted services. (a)...

  3. On some Frobenius Restriction Theorems for Semistable Sheaves

    Indian Academy of Sciences (India)

    V B Mehta; V Trivedi

    2009-02-01

    We prove a version of an effective Frobenius restriction theorem for semistable bundles in characteristic . The main novelty is in restricting the bundle to the -fold thickening of a hypersurface section. The base variety is /, an abelian variety or a smooth projective toric variety.

  4. 30 CFR 57.4461 - Gasoline use restrictions underground.

    Science.gov (United States)

    2010-07-01

    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Gasoline use restrictions underground. 57.4461... Prevention and Control Flammable and Combustible Liquids and Gases § 57.4461 Gasoline use restrictions underground. If gasoline is used underground to power internal combustion engines— (a) The mine shall...

  5. 32 CFR 538.3 - Restrictions on possession and use.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 3 2010-07-01 2010-07-01 true Restrictions on possession and use. 538.3 Section... MILITARY PAYMENT CERTIFICATES § 538.3 Restrictions on possession and use. (a) Possession or use prohibited. Possession or use of military payment certificates is prohibited unless acquired in accordance with §§...

  6. 50 CFR 648.235 - Possession and landing restrictions.

    Science.gov (United States)

    2010-10-01

    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Possession and landing restrictions. 648... Measures for the Spiny Dogfish Fishery § 648.235 Possession and landing restrictions. (a) Quota Period 1... calendar day. (c) Regulations governing the harvest, possession, landing, purchase, and sale of shark...

  7. 32 CFR 1903.16 - Restriction on animals.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 6 2010-07-01 2010-07-01 false Restriction on animals. 1903.16 Section 1903.16... AGENCY INSTALLATIONS § 1903.16 Restriction on animals. Animals, except for those animals used for the assistance of persons with disabilities, or animals under the charge and control of the Central...

  8. 32 CFR 234.12 - Restriction on animals.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Restriction on animals. 234.12 Section 234.12 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS CONDUCT ON THE PENTAGON RESERVATION § 234.12 Restriction on animals. Animals, except guide...

  9. 32 CFR 228.15 - Restriction regarding animals.

    Science.gov (United States)

    2010-07-01

    ... 32 National Defense 2 2010-07-01 2010-07-01 false Restriction regarding animals. 228.15 Section 228.15 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS SECURITY PROTECTIVE FORCE § 228.15 Restriction regarding animals. No animals...

  10. Acute sleep restriction reduces insulin sensitivity in adolescent boys

    DEFF Research Database (Denmark)

    Klingenberg, Lars; Chaput, Jean-Philippe; Holmbäck, Ulf;

    2013-01-01

    Short sleep duration has been linked to impaired glucose metabolism in many experimental studies. Moreover, studies have reported indications of an increased metabolic stress following sleep restriction.......Short sleep duration has been linked to impaired glucose metabolism in many experimental studies. Moreover, studies have reported indications of an increased metabolic stress following sleep restriction....

  11. 24 CFR 2004.26 - Restrictions that apply to testimony.

    Science.gov (United States)

    2010-04-01

    ... 24 Housing and Urban Development 5 2010-04-01 2010-04-01 false Restrictions that apply to testimony. 2004.26 Section 2004.26 Housing and Urban Development Regulations Relating to Housing and Urban... Production of Documents § 2004.26 Restrictions that apply to testimony. (a) The Counsel may impose...

  12. 75 FR 61612 - Airports/Locations: Special Operating Restrictions

    Science.gov (United States)

    2010-10-06

    ... ellen.crum@faa.gov . SUPPLEMENTARY INFORMATION: Background On November 30, 1999 (64 FR 66768), the FAA... Federal Aviation Administration 14 CFR Part 91 Airports/Locations: Special Operating Restrictions AGENCY... amending its airports and locations special operating restrictions regulation to clarify a...

  13. Recommendations of activity restriction in high-risk pregnancy scenarios

    DEFF Research Database (Denmark)

    Bendix, Jane; Hegaard, Hanne Kristine; Bergholt, Thomas;

    2015-01-01

    and the Danish Association of Midwives were asked to complete a tested, structured questionnaire. Results: We sent 1815 invitations; the overall response rate was 54%. A majority of clinicians recommended some form of activity restriction in the nine scenarios. The midwives recommended strict or moderate...... to the obstetricians, the midwives also reported that they expected the recommendation to be more effective. Most midwives and obstetricians reported that they thought strict activity restriction was associated with severe or moderate adverse effect, and recommended antithrombotic prophylaxis. Conclusions: Danish...... obstetricians and midwives prescribe activity restriction in most high-risk pregnancies. The degree of activity restriction and the presumed effect vary between clinicians. This may reflect different attitudes and lack of guidelines based on clinical studies of a possible benefit of activity restriction....

  14. Access to Minerals: WTO Export Restrictions and Climate Change Considerations

    Directory of Open Access Journals (Sweden)

    Stephanie Switzer

    2015-09-01

    Full Text Available In the past few years, the Chinese government opted to restrict the export of selected minerals on environmental and health grounds, subsequently leading to an uproar in countries and regions that rely heavily on imports from China to develop their renewable industry sector. This paper places the focus on the law and policy of the Chinese export restrictions of critical minerals, and its implications for the global renewables energy industry. The paper critically assesses how such export restrictions have been dealt with under the dispute settlement system of the World Trade Organisation (WTO. Drawing on this WTO jurisprudence, we posit that litigation on export restrictions of the kind imposed by China poses a threat to the legitimacy of the WTO. We therefore conclude by exploring whether there are any alternatives to litigation as a means to deal with countries choosing to impose mineral export restrictions.

  15. Quadratic Loss of Isotonic Normal Means Under Simultaneous Order Restrictions

    Institute of Scientific and Technical Information of China (English)

    马艳萍; 史宁中

    2002-01-01

    For two normal populations with unknown means μ and unknown variances σ2,assume that there are simple order restrictions among the means and variances:μ1≤μ2 and σ12≥σ22>0,This case is said to be simultaneous order restriction by Shi (Maximum likelihood estimation of means and variances from normal populations under simultaneous order restrictions.J.Multivariate,Anal.50(1994),282-293.)and an iterative algorithm of computing the order restricted maximum likelihood estimates of μi and σi2 was given in that paper,This paper shows that the restricted maximum likelihood estimate of μi has smaller mean square loss than the usual estimate xi under some conditions.

  16. Constructing Restricted Patterson Measures for Geometrically Infinite Kleinian Groups

    Institute of Scientific and Technical Information of China (English)

    Kurt FALK; Bernd O. STRATMANN

    2006-01-01

    In this paper, we study exhaustions, referred to as ρ-restrictions, of arbitrary nonelementary Kleinian groups with at most finitely many bounded parabolic elements. Special emphasis is put on the geometrically infinite case, where we obtain that the limit set of each of these Kleinian groups contains an infinite family of closed subsets, referred to as ρ-restricted limit sets, such that there in this family. Generalizing concepts which are well known in the geometrically finite case, we then introduce the notion of ρ-restricted Patterson measure, and show that these measures are non-atomic,δρ-harmonic, δρ-subconformal on special sets and δρ-conformal on very special sets. Furthermore, we obtain the results that each ρ-restriction of our Kleinian group is of δρ-divergence type and that the Hausdorff dimension of the ρ-restricted limit set is equal to δρ.

  17. Effect of dietary protein restriction on renal ammonia metabolism.

    Science.gov (United States)

    Lee, Hyun-Wook; Osis, Gunars; Handlogten, Mary E; Guo, Hui; Verlander, Jill W; Weiner, I David

    2015-06-15

    Dietary protein restriction has multiple benefits in kidney disease. Because protein intake is a major determinant of endogenous acid production, it is important that net acid excretion change in parallel during protein restriction. Ammonia is the primary component of net acid excretion, and inappropriate ammonia excretion can lead to negative nitrogen balance. Accordingly, we examined ammonia excretion in response to protein restriction and then we determined the molecular mechanism of the changes observed. Wild-type C57Bl/6 mice fed a 20% protein diet and then changed to 6% protein developed an 85% reduction in ammonia excretion within 2 days, which persisted during a 10-day study. The expression of multiple proteins involved in renal ammonia metabolism was altered, including the ammonia-generating enzymes phosphate-dependent glutaminase (PDG) and phosphoenolpyruvate carboxykinase (PEPCK) and the ammonia-metabolizing enzyme glutamine synthetase. Rhbg, an ammonia transporter, increased in expression in the inner stripe of outer medullary collecting duct intercalated cell (OMCDis-IC). However, collecting duct-specific Rhbg deletion did not alter the response to protein restriction. Rhcg deletion did not alter ammonia excretion in response to dietary protein restriction. These results indicate 1) dietary protein restriction decreases renal ammonia excretion through coordinated regulation of multiple components of ammonia metabolism; 2) increased Rhbg expression in the OMCDis-IC may indicate a biological role in addition to ammonia transport; and 3) Rhcg expression is not necessary to decrease ammonia excretion during dietary protein restriction. PMID:25925252

  18. Controlling pandemic flu: the value of international air travel restrictions.

    Directory of Open Access Journals (Sweden)

    Joshua M Epstein

    Full Text Available BACKGROUND: Planning for a possible influenza pandemic is an extremely high priority, as social and economic effects of an unmitigated pandemic would be devastating. Mathematical models can be used to explore different scenarios and provide insight into potential costs, benefits, and effectiveness of prevention and control strategies under consideration. METHODS AND FINDINGS: A stochastic, equation-based epidemic model is used to study global transmission of pandemic flu, including the effects of travel restrictions and vaccination. Economic costs of intervention are also considered. The distribution of First Passage Times (FPT to the United States and the numbers of infected persons in metropolitan areas worldwide are studied assuming various times and locations of the initial outbreak. International air travel restrictions alone provide a small delay in FPT to the U.S. When other containment measures are applied at the source in conjunction with travel restrictions, delays could be much longer. If in addition, control measures are instituted worldwide, there is a significant reduction in cases worldwide and specifically in the U.S. However, if travel restrictions are not combined with other measures, local epidemic severity may increase, because restriction-induced delays can push local outbreaks into high epidemic season. The per annum cost to the U.S. economy of international and major domestic air passenger travel restrictions is minimal: on the order of 0.8% of Gross National Product. CONCLUSIONS: International air travel restrictions may provide a small but important delay in the spread of a pandemic, especially if other disease control measures are implemented during the afforded time. However, if other measures are not instituted, delays may worsen regional epidemics by pushing the outbreak into high epidemic season. This important interaction between policy and seasonality is only evident with a global-scale model. Since the benefit of

  19. An Additive-Multiplicative Restricted Mean Residual Life Model

    DEFF Research Database (Denmark)

    Mansourvar, Zahra; Martinussen, Torben; Scheike, Thomas H.

    2016-01-01

    The mean residual life measures the expected remaining life of a subject who has survived up to a particular time. When survival time distribution is highly skewed or heavy tailed, the restricted mean residual life must be considered. In this paper, we propose an additive-multiplicative restricted...... mean residual life model to study the association between the restricted mean residual life function and potential regression covariates in the presence of right censoring. This model extends the proportional mean residual life model using an additive model as its covariate dependent baseline...

  20. Intracerebral metastasis showing restricted diffusion: Correlation with histopathologic findings

    Energy Technology Data Exchange (ETDEWEB)

    Duygulu, G. [Radiology Department, Ege University Medicine School, Izmir (Turkey); Ovali, G. Yilmaz [Radiology Department, Celal Bayar University Medicine School, Manisa (Turkey)], E-mail: gulgun.yilmaz@bayar.edu.tr; Calli, C.; Kitis, O.; Yuenten, N. [Radiology Department, Ege University Medicine School, Izmir (Turkey); Akalin, T. [Pathology Department, Ege University Medicine School, Izmir (Turkey); Islekel, S. [Neurosurgery Department, Ege University Medicine School, Izmir (Turkey)

    2010-04-15

    Objective: We aimed to detect the frequency of restricted diffusion in intracerebral metastases and to find whether there is correlation between the primary tumor pathology and diffusion-weighted MR imaging (DWI) findings of these metastases. Material and methods: 87 patients with intracerebral metastases were examined with routine MR imaging and DWI. 11 hemorrhagic metastatic lesions were excluded. The routine MR imaging included three plans before and after contrast enhancement. The DWI was performed with spin-echo EPI sequence with three b values (0, 500 and 1000), and ADC maps were calculated. 76 patients with metastases were grouped according to primary tumor histology and the ratios of restricted diffusion were calculated according to these groups. ADCmin values were measured within the solid components of the tumors and the ratio of metastases with restricted diffusion to that which do not show restricted diffusion were calculated. Fisher's exact and Mann-Whitney U tests were used for the statistical analysis. Results: Restricted diffusion was observed in a total of 15 metastatic lesions (19, 7%). Primary malignancy was lung carcinoma in 10 of these cases (66, 6%) (5 small cell carcinoma, 5 non-small cell carcinoma), and breast carcinoma in three cases (20%). Colon carcinoma and testicular teratocarcinoma were the other two primary tumors in which restricted diffusion in metastasis was detected. There was no statistical significant difference between the primary pathology groups which showed restricted diffusion (p > 0.05). ADCmin values of solid components of the metastasis with restricted diffusion and other metastasis without restricted diffusion also showed no significant statistical difference (0.72 {+-} 0.16 x 10{sup -3} mm{sup 2}/s and 0.78 {+-} 21 x 10{sup -3} mm{sup 2}/s respectively) (p = 0.325). Conclusion: Detection of restricted diffusion on DWI in intracerebral metastasis is not rare, particularly if the primary tumor is lung or breast

  1. Company Law as a Restriction to Free Movement

    DEFF Research Database (Denmark)

    Sørensen, Karsten Engsig

    2014-01-01

    Focusing on recent judgments from the Court of Justice of the European Union, this article investigates how the notion of ‘restriction’ – which is the first step in examining whether there is an infringement of the free movement rights – is used in cases involving company law measures....... There is evidence that non-discriminatory obstacles to free movement found in company law can be restrictions. However, recent cases show that the Court may be willing to apply a more restrictive approach where only non-discriminatory measures that have a qualified deterrent effect may constitute restrictions....

  2. A comparative study on the restrictions of dynamic test methods

    Science.gov (United States)

    Majzoobi, GH.; Lahmi, S.

    2015-09-01

    Dynamic behavior of materials is investigated using different devices. Each of the devices has some restrictions. For instance, the stress-strain curve of the materials can be captured at high strain rates only with Hopkinson bar. However, by using a new approach some of the other techniques could be used to obtain the constants of material models such as Johnson-Cook model too. In this work, the restrictions of some devices such as drop hammer, Taylor test, Flying wedge, Shot impact test, dynamic tensile extrusion and Hopkinson bars which are used to characterize the material properties at high strain rates are described. The level of strain and strain rate and their restrictions are very important in examining the efficiency of each of the devices. For instance, necking or bulging in tensile and compressive Hopkinson bars, fragmentation in dynamic tensile extrusion and petaling in Taylor test are restricting issues in the level of strain rate attainable in the devices.

  3. A comparative study on the restrictions of dynamic test methods

    Directory of Open Access Journals (Sweden)

    Majzoobi GH.

    2015-01-01

    Full Text Available Dynamic behavior of materials is investigated using different devices. Each of the devices has some restrictions. For instance, the stress-strain curve of the materials can be captured at high strain rates only with Hopkinson bar. However, by using a new approach some of the other techniques could be used to obtain the constants of material models such as Johnson-Cook model too. In this work, the restrictions of some devices such as drop hammer, Taylor test, Flying wedge, Shot impact test, dynamic tensile extrusion and Hopkinson bars which are used to characterize the material properties at high strain rates are described. The level of strain and strain rate and their restrictions are very important in examining the efficiency of each of the devices. For instance, necking or bulging in tensile and compressive Hopkinson bars, fragmentation in dynamic tensile extrusion and petaling in Taylor test are restricting issues in the level of strain rate attainable in the devices.

  4. 3-restricted connectivity of graphs with given girth

    Institute of Scientific and Technical Information of China (English)

    GUO Li-tao; MENG Ji-xiang

    2008-01-01

    Let G = (V, E) be a connected graph. X C V(G) is a vertex set. X is a 3-restricted cut of G, if G-X is not connected and every component of G-X has at least three vertices. The 3-restricted connectivity k3(G) (in short k3) of G is the cardinality of a minimum 3-restricted cut of G. Χ is called κ3-cut, if Χ = κ3. A graph G is κa-connected, if a 3-restricted cut exists.Let G be a graph girth g ≥ 4, ξ3(G) is min{d(χ) + d(у) + d(z) - 4 : χуz is a 2-path of G}. It will be shown that κ3(G) = ξ3(G) under the condition of girth.

  5. United States: Funding restrictions threaten sex workers' rights.

    Science.gov (United States)

    Schleifer, Rebecca

    2005-08-01

    Recent developments concerning the US government's restrictive policies on HIV/AIDS funding have drawn attention to how the government's mandatory "anti-prostitution pledge" endangers the lives of sex workers and trafficking victims. PMID:16365969

  6. Total sleep deprivation, chronic sleep restriction and sleep disruption.

    Science.gov (United States)

    Reynolds, Amy C; Banks, Siobhan

    2010-01-01

    Sleep loss may result from total sleep deprivation (such as a shift worker might experience), chronic sleep restriction (due to work, medical conditions or lifestyle) or sleep disruption (which is common in sleep disorders such as sleep apnea or restless legs syndrome). Total sleep deprivation has been widely researched, and its effects have been well described. Chronic sleep restriction and sleep disruption (also known as sleep fragmentation) have received less experimental attention. Recently, there has been increasing interest in sleep restriction and disruption as it has been recognized that they have a similar impact on cognitive functioning as a period of total sleep deprivation. Sleep loss causes impairments in cognitive performance and simulated driving and induces sleepiness, fatigue and mood changes. This review examines recent research on the effects of sleep deprivation, restriction and disruption on cognition and neurophysiologic functioning in healthy adults, and contrasts the similarities and differences between these three modalities of sleep loss.

  7. Miscarriage and early first trimester growth restriction by ultrasound

    Directory of Open Access Journals (Sweden)

    Neelima Agarwal

    2016-05-01

    Conclusions: CRL was significantly smaller in pregnancies that subsequently ended in miscarriage. This suggests that early first trimester growth restriction is associated with subsequent intrauterine death. [Int J Reprod Contracept Obstet Gynecol 2016; 5(5.000: 1558-1561

  8. Personal paths of fluid restriction in patients on hemodialysis.

    Science.gov (United States)

    Tovazzi, Maria Elena; Mazzoni, Valentina

    2012-01-01

    The aim of this study was to explore the perspectives of patients on hemodialysis about their experience of fluid restriction. Qualitative interviews were conducted to grasp the patients' lived experience, and from a phenomenological analysis, several categories emerged that describe patients' understanding. Three themes in particular from patients' experiences are described and discussed because of their relevance for health professionals. These include (a) fluid restriction introduces the perception of individuals to see themselves as addicts who deal with a constant inner conflict, (b) the difficulty in finding the right boundaries between common sense and scientific knowledge about fluid restriction, and (c) the role of personal motivations and willingness in pursuit of compliance. Recognizing the force of personal meaning for individuals with renal disease will support health professionals to help patients in pursuing the regime of fluid restriction. PMID:22866360

  9. HCUP State Emergency Department Databases (SEDD) - Restricted Access File

    Data.gov (United States)

    U.S. Department of Health & Human Services — The State Emergency Department Databases (SEDD) contain the universe of emergency department visits in participating States. Restricted access data files are...

  10. Grout Treatment Facility Land Disposal Restriction Management Plan

    International Nuclear Information System (INIS)

    This document establishes management plans directed to result in the land disposal of grouted wastes at the Hanford Grout Facilities in compliance with Federal, State of Washington, and Department of Energy land disposal restrictions. 9 refs., 1 fig

  11. Caloric restriction and Metabolism in Lean and Obese rats.

    Data.gov (United States)

    U.S. Environmental Protection Agency — Data related to obese and lean strains of rat commonly used in the laboratory that are calorically restricted and its effects on physiologic parameters (Body...

  12. Flow-test device fits into restricted access passages

    Science.gov (United States)

    Fitzgerald, J. J.; Oberschmidt, M.; Rosenbaum, B. J.

    1967-01-01

    Test device using a mandrel with a collapsible linkage assembly enables a fluid flow sensor to be properly positioned in a restricted passage by external manipulation. This device is applicable to the combustion chamber of a rocket motor.

  13. 48 CFR 225.7012 - Restriction on supercomputers.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Restriction on supercomputers. 225.7012 Section 225.7012 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS... supercomputers....

  14. Status of selected nutrients in obese dogs undergoing caloric restriction

    OpenAIRE

    Linder, Deborah E; Freeman, Lisa M.; Holden, Shelley L; Biourge, Vincent; German, Alexander J.

    2013-01-01

    Background The purpose of this study was to test the hypothesis that dog plasma concentrations of selected nutrients decrease after undergoing caloric restriction for weight loss. Thirty-one overweight dogs that had successfully lost at least 15% of initial body weight were included in the study. Nutrients that had been previously identified to be at potential risk of deficiency during caloric restriction were measured in plasma (choline, amino acids) and urine (selenium) at the initiation an...

  15. Insights into restrictive cardiomyopathy from clinical and animal studies

    OpenAIRE

    Jean-Charles, Pierre-Yves; Li, Yue-Jin; Nan, Chang-Long; Huang, Xu-Pei

    2011-01-01

    Cardiomyopathies are diseases that primarily affect the myocardium, leading to serious cardiac dysfunction and heart failure. Out of the three major categories of cardiomyopathies (hypertrophic, dilated and restrictive), restrictive cardiomyopathy (RCM) is less common and also the least studied. However, the prognosis for RCM is poor as some patients dying in their childhood. The molecular mechanisms behind the disease development and progression are not very clear and the treatment of RCM is...

  16. Conforming restricted Delaunay mesh generation for piecewise smooth complexes

    OpenAIRE

    Engwirda, Darren

    2016-01-01

    A Frontal-Delaunay refinement algorithm for mesh generation in piecewise smooth domains is described. Built using a restricted Delaunay framework, this new algorithm combines a number of novel features, including: (i) a consistent, conforming restricted Delaunay representation for domains specified as a (non-manifold) collection of piecewise smooth surface patches and curve constraints, (ii) a `protection' strategy for domains containing 1-dimensional features that meet at sharply acute angle...

  17. Supporting several levels of restriction in the UML

    DEFF Research Database (Denmark)

    Hansen, Klaus Marius; Damm, Christian Heide; Thomsen, Michael;

    2000-01-01

    The emergence of the Unified Modeling Language (UML) has provided software developers with an effective and efficient shared language. However, UML is often too restrictive in initial, informal, and creative modelling, and it is in some cases not restrictive enough, e.g., for code generation. Based....... This approach potentially increases the usability of the UML, and thus ultimately leads to greater quality and adoption of UML models....

  18. Restriction Enzyme Digestion Exercise – An In-class Activity

    OpenAIRE

    Michelle Parent

    2010-01-01

    Understanding the concepts of molecular biology and then applying those concepts to laboratory experiments can be challenging to entry-level students. In order to facilitate the topics of restriction enzyme digestion and the generation of compatible ends in the process of gene cloning, an in-class activity was designed. This restriction enzyme digestion exercise, designed for an introductory undergraduate course in genetics, molecular biology and molecular diagnostics, can be utilized ...

  19. Neutron inelastic scattering from {sup 4}He in restricted geometries

    Energy Technology Data Exchange (ETDEWEB)

    Gibbs, M.R. [Keele Univ. (United Kingdom). Dept. of Physics; Sokol, P.E. [Dept. of Physics, Pennsylvania State Univ., University Park, PA (United States); Azuah, R.T. [Keele Univ. (United Kingdom). Dept. of Physics]|[Rutherford Appleton Lab., Chilton, Didcot (United Kingdom); Stirling, W.G. [Keele Univ. (United Kingdom). Dept. of Physics; Adams, M.A. [Rutherford Appleton Lab., Chilton, Didcot (United Kingdom)

    1995-08-01

    When liquid {sup 4}He is condensed in porous aerogel glass (typical pore size {approx}5000 A), many of the superfluid properties are significantly altered. Measurements have been made of the dynamic structure factor S(Q,{omega}) of liquid {sup 4}He in restricted geometries. The collective phonon-roton excitations are shown to have an intrinsic broadening associated with the restricted geometry. The temperature dependence of the excitation spectrum is discussed. (orig.).

  20. Quons Restricted to the Antisymmetric Subspace Formalism and Applications

    CERN Document Server

    Avancini, S S; Marinelli, J R; Peres-Menezes, D; Watanabe de Moraes, M M

    2003-01-01

    In this work we develop a formalism to treat quons restricted to the antisymmetric part of their many-body space. A model in which a system of identical quons interact through a pairing force is then solved within this restriction and the differences between our solution and the usual fermionic model solution are then presented and discussed in detail. Possible connections to physical systems are also considered.

  1. Benefits of short-term dietary restriction in mammals

    OpenAIRE

    Robertson, Lauren T.; Mitchell, James R.

    2013-01-01

    Dietary or calorie restriction (DR, CR), defined as reduced food intake without malnutrition, imparts many benefits in model organisms. Extended longevity is the most popularized benefit but the least clinically relevant due to the requirement for long-term food restriction. DR also promotes stress resistance and metabolic fitness. Emerging data in experimental models and in humans indicate that these benefits occur rapidly upon initiation of DR, suggesting potential clinical relevance. Here ...

  2. Unintended Pregnancies, Restrictive Abortion Laws, and Abortion Demand

    OpenAIRE

    Medoff, Marshall H.

    2012-01-01

    This study examines the effect restrictive state abortion laws have on the pregnancy resolution decisions of women with unintended pregnancies. The empirical results find that the abortion ratio and the abortion rate of unintended pregnancies are more sensitive to increases in the abortion price than previous estimates that analyzed total pregnancies (unintended and intended). A Medicaid funding restriction has very little effect on a state's abortion rate of unintended pregnancies, but cause...

  3. IS-linked movement of a restriction-modification system.

    Directory of Open Access Journals (Sweden)

    Noriko Takahashi

    Full Text Available Potential mobility of restriction-modification systems has been suggested by evolutionary/bioinformatic analysis of prokaryotic genomes. Here we demonstrate in vivo movement of a restriction-modification system within a genome under a laboratory condition. After blocking replication of a temperature-sensitive plasmid carrying a PaeR7I restriction-modification system in Escherichia coli cells, the plasmid was found integrated into the chromosome of the surviving cells. Sequence analysis revealed that, in the majority of products, the restriction-modification system was linked to chromosomal insertion sequences (ISs. Three types of products were: (I apparent co-integration of the plasmid and the chromosome at a chromosomal IS1 or IS5 copy (24/28 analyzed; (II de novo insertion of IS1 with the entire plasmid except for a 1-3 bp terminal deletion (2/28; and (III reciprocal crossing-over between the plasmid and the chromosome involving 1-3 bp of sequence identity (2/28. An R-negative mutation apparently decreased the efficiency of successful integration by two orders of magnitude. Reconstruction experiments demonstrated that the restriction-dependence was mainly due to selection against cells without proper integration: their growth was inhibited by the restriction enzyme action. These results demonstrate collaboration of a mobile element and a restriction-modification system for successful joint migration. This collaboration may have promoted the spread and, therefore, the long-term persistence of these complexes and restriction-modification systems in a wide range of prokaryotes.

  4. Cornering the market: restriction of retail supermarket locations

    OpenAIRE

    Nairne Cameron; Carl G Amrhein; Karen E Smoyer-Tomic; Raine, Kim D; Lee Yen Chong

    2010-01-01

    A major source of healthy foods, North American supermarkets have become larger in recent years, with new stores opening and older stores closing. Upon closure, there is evidence of some supermarket sites being placed under restrictive covenants, a practice that restricts future use of the site. The purpose is usually to limit food sales at the location, thus minimizing competition for a chain’s nearby stores. In Edmonton, Alberta eighteen covenants have been documented on former supermarket ...

  5. Personnel Tour Scheduling When Starting-Time Restrictions Are Present

    OpenAIRE

    Michael J. Brusco; Larry W. Jacobs

    1998-01-01

    This paper presents an effective solution strategy for an important category of personnel scheduling problems. Specifically, we address the restricted starting-time tour-scheduling problem (RSTP), which involves the determination of the hours of the day (shifts) and days of the week (days on) that employees are assigned to work. RSTP is characterized by restrictions on the number of daily time periods in which employees may begin their shifts. Moreover, the RSTP we consider contains constrain...

  6. Animal models of restricted repetitive behavior in autism

    OpenAIRE

    Lewis, Mark H.; Tanimura, Yoko; Lee, Linda W.; Bodfish, James W.

    2006-01-01

    Restricted, repetitive behavior, along with deficits in social reciprocity and communication, is diagnostic of autism. Animal models relevant to this domain generally fall into three classes: repetitive behavior associated with targeted insults to the CNS; repetitive behavior induced by pharmacological agents; and repetitive behavior associated with restricted environments and experience. The extant literature provides potential models of the repetitive behavioral phenotype in autism rather t...

  7. Agricultural Production Restrictions and Market Power: An Antitrust Analysis

    OpenAIRE

    Bolotova, Yuliya

    2015-01-01

    During the recent decade the organizations of agricultural producers in the national dairy, potato, egg and mushroom industries implemented various pre-production and production restriction practices with the primary objective of agricultural output price stabilization. The buyers of the affected agricultural commodities have challenged the legal status of production restrictions in a number of recent and current antitrust lawsuits, arguing that the Capper-Volstead Act, a limited antitrust ex...

  8. Advanced Mean Field Theory of Restricted Boltzmann Machine

    OpenAIRE

    Huang, Haiping; Toyoizumi, Taro

    2015-01-01

    Learning in restricted Boltzmann machine is typically hard due to the computation of gradients of log-likelihood function. To describe the network state statistics of the restricted Boltzmann machine, we develop an advanced mean field theory based on the Bethe approximation. Our theory provides an efficient message passing based method that evaluates not only the partition function (free energy) but also its gradients without requiring statistical sampling. The results are compared with those...

  9. Identification of leptospiral isolates by bacterial restriction endonuclease analysis (Brenda

    Directory of Open Access Journals (Sweden)

    Venkatesha M

    2001-01-01

    Full Text Available DNA samples from 19 reference serovars belonging to 19 different serogroups of Leptospira interrogans and two serovars belonging to Leptospira biflexa were examined by bacterial restriction endonuclease analysis using EcoR I and Hae III enzymes. All the serovars gave unique restriction patterns that differed from each other. DNA from 10 local isolates digested with these enzymes produced patterns which on comparison with the standard patterns produced by reference strains could be identified to serovar level.

  10. Chronic Maternal Dietary Chromium Restriction Modulates Visceral Adiposity

    OpenAIRE

    Padmavathi, Inagadapa J.N.; Rao, K Rajender; Venu, Lagishetty; Ganeshan, Manisha; Kumar, K. Anand; Rao, Ch. Narasima; Harishankar, Nemani; Ismail, Ayesha; Raghunath, Manchala

    2009-01-01

    OBJECTIVE We demonstrated previously that chronic maternal micronutrient restriction altered the body composition in rat offspring and may predispose offspring to adult-onset diseases. Chromium (Cr) regulates glucose and fat metabolism. The objective of this study is to determine the long-term effects of maternal Cr restriction on adipose tissue development and function in a rat model. RESEARCH DESIGN AND METHODS Female weanling WNIN rats received, ad libitum, a control diet or the same with ...

  11. Temporary feed restriction partially protects broilers from necrotic enteritis.

    Science.gov (United States)

    Tsiouris, V; Georgopoulou, I; Batzios, Chr; Pappaioannou, N; Ducatelle, R; Fortomaris, P

    2014-01-01

    The objective of this study was to investigate the effect of feed restriction on the intestinal ecosystem and on the pathogenesis of experimental necrotic enteritis in broiler chicks. To induce subclinical necrotic enteritis, an experimental challenge model using a specific diet formulation, Gumboro vaccination, oral inoculation of broilers with a 10-fold dose of attenuated anticoccidial vaccine and multiple oral inoculations with a specific strain of Clostridium perfringens was adopted. Two hundred and forty 1-day-old Cobb 500 broilers were randomly allocated to four groups: feed restricted, challenged, both feed restricted and challenged, and negative control. At 21, 22, 23 and 24 days of age, the intestines, gizzard and liver were collected from 15 birds in each group and scored for gross lesions. The intestinal digesta was collected for pH and viscosity determination. One caecum from each bird was taken for microbiological analysis. The application of feed restriction in birds challenged with C. perfringens reduced the necrotic enteritis lesion score significantly (P ≤ 0.05) and feed restriction significantly reduced (P ≤ 0.05) pH in the small intestine, the viscosity of the jejunum digesta as well as the C. perfringens counts in the caeca compared with the controls. In conclusion, feed restriction of broilers has a positive effect on the intestinal ecosystem and a significant protective effect against necrotic enteritis in the subclinical experimental model.

  12. Physiogenomic analysis of weight loss induced by dietary carbohydrate restriction

    Directory of Open Access Journals (Sweden)

    Wood Richard J

    2006-05-01

    Full Text Available Abstract Background Diets that restrict carbohydrate (CHO have proven to be a successful dietary treatment of obesity for many people, but the degree of weight loss varies across individuals. The extent to which genetic factors associate with the magnitude of weight loss induced by CHO restriction is unknown. We examined associations among polymorphisms in candidate genes and weight loss in order to understand the physiological factors influencing body weight responses to CHO restriction. Methods We screened for genetic associations with weight loss in 86 healthy adults who were instructed to restrict CHO to a level that induced a small level of ketosis (CHO ~10% of total energy. A total of 27 single nucleotide polymorphisms (SNPs were selected from 15 candidate genes involved in fat digestion/metabolism, intracellular glucose metabolism, lipoprotein remodeling, and appetite regulation. Multiple linear regression was used to rank the SNPs according to probability of association, and the most significant associations were analyzed in greater detail. Results Mean weight loss was 6.4 kg. SNPs in the gastric lipase (LIPF, hepatic glycogen synthase (GYS2, cholesteryl ester transfer protein (CETP and galanin (GAL genes were significantly associated with weight loss. Conclusion A strong association between weight loss induced by dietary CHO restriction and variability in genes regulating fat digestion, hepatic glucose metabolism, intravascular lipoprotein remodeling, and appetite were detected. These discoveries could provide clues to important physiologic adaptations underlying the body mass response to CHO restriction.

  13. Calorie for calorie, dietary fat restriction results in more body fat loss than carbohydrate restriction in people with obesity

    Science.gov (United States)

    Hall, Kevin D.; Bemis, Thomas; Brychta, Robert; Chen, Kong Y.; Courville, Amber; Crayner, Emma J.; Goodwin, Stephanie; Guo, Juen; Howard, Lilian; Knuth, Nicolas D.; Miller, Bernard V.; Prado, Carla M.; Siervo, Mario; Skarulis, Monica C.; Walter, Mary; Walter, Peter J.; Yannai, Laura

    2015-01-01

    Summary Dietary carbohydrate restriction has been purported to cause endocrine adaptations that promote body fat loss more than dietary fat restriction. We selectively restricted dietary carbohydrate versus fat for 6 days following a 5 day baseline diet in 19 adults with obesity confined to a metabolic ward where they exercised daily. Subjects received both isocaloric diets in random order during each of two inpatient stays. Body fat loss was calculated as the difference between daily fat intake and net fat oxidation measured while residing in a metabolic chamber. Whereas carbohydrate restriction led to sustained increases in fat oxidation and loss of 53±6 g/d of body fat, fat oxidation was unchanged by fat restriction leading to 89±6 g/d of fat loss and was significantly greater than carbohydrate restriction (p=0.002). Mathematical model simulations agreed with these data, but predicted that the body acts to minimize body fat differences with isocaloric diets varying in carbohydrate and fat. PMID:26278052

  14. Alteration of placental haemostatic mechanisms in idiopathic intrauterine growth restriction

    Directory of Open Access Journals (Sweden)

    Jaime Eduardo Bernal Villegas

    2012-08-01

    Full Text Available Intrauterine growth restriction is a complication of pregnancy with a high probability of perinatal morbidity and mortality. It appears tobe caused by abnormal development of placental vasculature. Haemostatic processes are important for the development of the placenta,and an imbalance between procoagulant and anticoagulant factors has been associated with risk of intrauterine growth restriction.Objective. To evaluate coagulation abnormalities in placenta of pregnancies complicated with idiopathic intrauterine growth restriction.Materials and methods. Five placentas from pregnancies with idiopathic intrauterine growth restriction were compared to 19 controls.We performed gross and histological examination of the placenta. Analysis was made of both mRNA expression by real-time PCRand protein by ELISA of tissue factor and thrombomodulin in placental tissue. Results. Results based on histological evaluation wereconsistent with an increased prothrombotic state in placentas from pregnancies with idiopathic intrauterine growth restriction, andthrombosis of chorionic vessels was the most important finding. The study showed an increased expression of tissue factor protein(p=0.0411 and an increase in the ratio of tissue factor/thrombomodulin mRNA (p=0.0411 and protein (p=0.0215 in placentas frompregnancies with idiopathic intrauterine growth restriction. There were no statistically significant differences neither between cases andcontrols in the mRNA levels of tissue factor or thrombomodulin nor at the protein level of thrombomodulin. Conclusion. Evidence ofalteration of local haemostatic mechanisms at the level of the placenta, including abnormal expression of tissue factor and tissue factor/thrombomodulin ratio, in pregnancies that occur with idiopathic intrauterine growth restriction is presented.

  15. HIV restriction by APOBEC3 in humanized mice.

    Directory of Open Access Journals (Sweden)

    John F Krisko

    2013-03-01

    Full Text Available Innate immune restriction factors represent important specialized barriers to zoonotic transmission of viruses. Significant consideration has been given to their possible use for therapeutic benefit. The apolipoprotein B mRNA editing enzyme catalytic polypeptide 3 (APOBEC3 family of cytidine deaminases are potent immune defense molecules capable of efficiently restricting endogenous retroelements as well as a broad range of viruses including Human Immunodeficiency virus (HIV, Hepatitis B virus (HBV, Human Papilloma virus (HPV, and Human T Cell Leukemia virus (HTLV. The best characterized members of this family are APOBEC3G (A3G and APOBEC3F (A3F and their restriction of HIV. HIV has evolved to counteract these powerful restriction factors by encoding an accessory gene designated viral infectivity factor (vif. Here we demonstrate that APOBEC3 efficiently restricts CCR5-tropic HIV in the absence of Vif. However, our results also show that CXCR4-tropic HIV can escape from APOBEC3 restriction and replicate in vivo independent of Vif. Molecular analysis identified thymocytes as cells with reduced A3G and A3F expression. Direct injection of vif-defective HIV into the thymus resulted in viral replication and dissemination detected by plasma viral load analysis; however, vif-defective viruses remained sensitive to APOBEC3 restriction as extensive G to A mutation was observed in proviral DNA recovered from other organs. Remarkably, HIV replication persisted despite the inability of HIV to develop resistance to APOBEC3 in the absence of Vif. Our results provide novel insight into a highly specific subset of cells that potentially circumvent the action of APOBEC3; however our results also demonstrate the massive inactivation of CCR5-tropic HIV in the absence of Vif.

  16. Adaptation funding and development assistance: some FAQs

    Energy Technology Data Exchange (ETDEWEB)

    Ayers, Jessica; Huq, Saleemul

    2008-11-15

    It's becoming ever clearer that development and climate change are intertwined issues. Unsustainable development drives climate change; sustainable development can reduce vulnerability to it. Development issues can constrain capacity to adapt to climate change; climate impacts can be a barrier to development. So adaptation to climate impacts is increasingly seen as part of good development practice – and development to improve the lives and resource access of people facing climate challenges is viewed as a prerequisite for successful adaptation. But when it comes to adaptation funding, confusion and contention remain over the role development institutions play.

  17. FAQ: Insect Repellent Use and Safety

    Science.gov (United States)

    ... Surveillance Software Health Education Public Service Videos Insect Repellent Use & Safety Recommend on Facebook Tweet Share Compartir ... insect repellent products? What is permethrin? Which mosquito repellents work best? CDC recommends the use of products ...

  18. UML Semantics FAQ: Dynamic Behaviour and Concurrency

    NARCIS (Netherlands)

    Wieringa, Roel; Astesiano, Egidio; Reggio, Gianna; Le Guennec, Alain; Hussman, Heinrich; Berg, van den Klaas; Broek, van den Pim; Demeyer, Serge

    1999-01-01

    This paper reports the results of a workshop held at ECOOP'99. The workshop was set up to find answers to questions fundamental to the definition of a semantics for the Unified Modelling Language. Questions examined the meaning of the term semantics in the context of UML; approaches to defining the

  19. FAQs of Pregnancy Loss and Miscarriage

    Science.gov (United States)

    ... for miscarriage in a subsequent pregnancy? Is there anything a woman can do to prevent a pregnancy ... Most of the time, a woman cannot do anything to prevent a miscarriage. Getting preconception care and ...

  20. Dipylidium (Dog and Cat Flea Tapeworm) FAQs

    Science.gov (United States)

    ... if my pet has a tapeworm infection? Although cats and dogs are rarely ill as a result of a ... and outdoor environments. Have your veterinarian treat your dogs and cats promptly if they have tapeworms. Clean up after ...

  1. Contraception and Birth Control: Other FAQs

    Science.gov (United States)

    ... health, age, frequency of sexual activity, number of sexual partners, desire to have children in the future, and family history of certain diseases. Individuals should consult their health care ... methods with your sexual partner. What are the health risks and side ...

  2. ISSN Roundtable: FAQs About the ISSN

    OpenAIRE

    Kreider Richard; Kleiner Susan; Katch Frank; Kalman Douglas; Gann Marc; Antonio Jose; Willoughby Darryn

    2005-01-01

    Mission Statement of the ISSN The mission of the International Society of Sports Nutrition is to be recognized as the leading professional organization in the study and application of sports nutrition. The ISSN is dedicated to promoting and supporting the study, practice, education, research and development of sports nutrition and the sports nutrition profession. All information disseminated by the ISSN is unbiased and scientifically supported.

  3. ISSN Roundtable: FAQs About the ISSN.

    Science.gov (United States)

    Antonio, Jose; Gann, Marc; Kalman, Douglas; Katch, Frank; Kleiner, Susan; Kreider, Richard; Willoughby, Darryn

    2005-01-01

    : MISSION STATEMENT OF THE ISSN : The mission of the International Society of Sports Nutrition is to be recognized as the leading professional organization in the study and application of sports nutrition. The ISSN is dedicated to promoting and supporting the study, practice, education, research and development of sports nutrition and the sports nutrition profession. All information disseminated by the ISSN is unbiased and scientifically supported. PMID:18500952

  4. Cervical screening: Frequently asked questions (FAQs)

    OpenAIRE

    Public Health Agency

    2012-01-01

    Testing for high-risk human papillomavirus (HR-HPV) as triage and test of cure was introduced into the Northern Ireland Cervical Screening Programme on Monday 28 January 2013. This policy change will significantly alter the screening pathway for women with a mild dyskaryosis or borderline smear result. The link between HR-HPV infection and the development of cervical cancer has now been clearly established, with almost 100% of cervical cancers containing HPV DNA. Women with no evidence of HR-...

  5. Frequently Asked Questions (FAQ) about Plague

    Science.gov (United States)

    ... Del.icio.us Digg Facebook Google Bookmarks Technorati Yahoo MyWeb Updates Subscribe Listen Page last updated April ... Del.icio.us Digg Facebook Google Bookmarks Technorati Yahoo MyWeb Download page Subscribe to RSS Get email ...

  6. Tracks FAQs: What is Modeled Air Data?

    Centers for Disease Control (CDC) Podcasts

    2011-04-25

    In this podcast, CDC Tracking experts discuss modeled air data. Do you have a question for our Tracking experts? Please e-mail questions to trackingsupport@cdc.gov.  Created: 4/25/2011 by National Center for Environmental Health, Division of Environmental Hazards and Health Effects, Environmental Health Tracking Branch.   Date Released: 4/25/2011.

  7. Trichinellosis (also known as Trichinosis) FAQs

    Science.gov (United States)

    ... called Trichinella . Infection occurs commonly in certain wild carnivorous (meat-eating) animals such as bear or cougar, ... trichinellosis? See your health care provider who can order tests and treat symptoms of trichinellosis infection. If ...

  8. FAQ about Recreational Therapy/Therapeutic Recreation

    Science.gov (United States)

    ... is the relationship between recreational therapy and therapeutic recreation? Therapeutic Recreation is the field ​​Recreational ... for individuals with disabilities." About the American Therapeutic Recreation Association: The American Therapeutic Recreation Association (ATRA) is ...

  9. FAQ: Blood Donation and Organ Transplant

    Science.gov (United States)

    ... Mosquito Surveillance Software Health Education Public Service Videos Blood Donation & Organ Transplant Recommend on Facebook Tweet Share ... get infected with West Nile virus by donating blood? No. You cannot get West Nile virus by ...

  10. Frequently Asked Questions (FAQs) about Malaria

    Science.gov (United States)

    ... Where Malaria Occurs Eradication The Disease What is malaria? Malaria is a serious and sometimes fatal disease ... and poverty. Top of Page How People Get Malaria (Transmission) How is malaria transmitted? Usually, people get ...

  11. Lymphatic Filariasis: Frequently Asked Questions (FAQs)

    Science.gov (United States)

    ... the treatment for lymphatic filariasis? What is lymphatic filariasis? Lymphatic filariasis is a parasitic disease caused by ... worms in the United States. How is lymphatic filariasis spread? The disease spreads from person to person ...

  12. FAQ: General Questions about West Nile Virus

    Science.gov (United States)

    ... Public Service Videos General Questions About West Nile Virus Recommend on Facebook Tweet Share Compartir On this ... West Nile virus cases? What is West Nile virus? West Nile virus is an arthropod-borne virus ( ...

  13. Pregnancy Precautions: FAQs on Pregnancy Hazards

    Science.gov (United States)

    ... including mousse, tiramisu, raw cookie dough, eggnog, homemade ice cream, and Caesar dressing raw or undercooked fish (sushi), ... high blood pressure (hypertension) or blood clots, a history of miscarriage, premature labor, ectopic pregnancy, or other ...

  14. FAQS. III: Groupwork in Distance Learning.

    Science.gov (United States)

    Felder, Richard M.; Brent, Rebecca

    2001-01-01

    Offers ideas for getting students at remote sites to collaborate when attending lectures in a synchronous course, working through lessons in an asynchronous course, and doing homework in either distance mode. (ASK)

  15. Restrictions on Software for Personal and Professional Use

    CERN Multimedia

    2004-01-01

    A growing number of computer security incidents detected at CERN are due to additional software installed for personal and professional use. As a consequence, the smooth operation of CERN is put at risk and often many hours are lost solving the problems. To reduce this security risk, installation and/or use of software on CERN's computing and network infrastructure needs to be restricted. Therefore: Do NOT install software for personal use Do NOT install 'free' or other software unless you have the expertise to configure and maintain it securely. Please comply to these rules to keep our computer systems safe. Further explanation of these restrictions is at http://cern.ch/security/software-restrictions Restricted software, known to cause security and/or network problems (e.g. KaZaA and other P2P/Peer-to-Peer file sharing applications, Skype P2P telephony software, ICQ, VNC, ...), is listed at: http://cern.ch/security/software-restrictions/list

  16. Interplay Between Bacteriophages and Restriction-Modification Systems in Enterococci

    Directory of Open Access Journals (Sweden)

    Pristas Peter

    2014-06-01

    Full Text Available The complete genomes of Enterococcus faecalis bacteriophages were analyzed for tetranucleotide words avoidance. Very similar tetranucleotide composition was found in all tested genomes with strong underrepresentation of palindromic GATC and GGCC words. This avoidance could be explained as a protection mechanism against host restriction-modification systems as a clear correlation was found between avoidance of palindromic words and the specificity of E. faecalis restriction and modification systems. No similar avoidance of tetranucleotide words was observed for non-palindromic words. A weak correlation was observed between avoidance of tetranucleotide palindromes in bacteriophage genomes and the possession of phage encoded DNA methyltransferases confirming the interrelation between bacteriophage genomes composition and restriction and modification systems in enterococci

  17. Paternally Inherited IGF2 Mutation and Growth Restriction.

    Science.gov (United States)

    Begemann, Matthias; Zirn, Birgit; Santen, Gijs; Wirthgen, Elisa; Soellner, Lukas; Büttel, Hans-Martin; Schweizer, Roland; van Workum, Wilbert; Binder, Gerhard; Eggermann, Thomas

    2015-07-23

    In humans, mutations in IGF1 or IGF1R cause intrauterine and postnatal growth restriction; however, data on mutations in IGF2, encoding insulin-like growth factor (IGF) II, are lacking. We report an IGF2 variant (c.191C→A, p.Ser64Ter) with evidence of pathogenicity in a multigenerational family with four members who have growth restriction. The phenotype affects only family members who have inherited the variant through paternal transmission, a finding that is consistent with the maternal imprinting status of IGF2. The severe growth restriction in affected family members suggests that IGF-II affects postnatal growth in addition to prenatal growth. Furthermore, the dysmorphic features of affected family members are consistent with a role of deficient IGF-II levels in the cause of the Silver-Russell syndrome. (Funded by Bundesministerium für Bildung und Forschung and the European Union.).

  18. Sequence specific inhibition of DNA restriction enzyme cleavage by PNA

    DEFF Research Database (Denmark)

    Nielsen, P.E.; Egholm, M.; Berg, R.H.;

    1993-01-01

    Plasmids containing double-stranded 10-mer PNA (peptide nucleic acid chimera) targets proximally flanked by two restriction enzyme sites were challenged with the complementary PNA or PNAs having one or two mismatches, and the effect on the restriction enzyme cleavage of the flanking sites...... was assayed. The following PNAs were used: T10-LysNH2, T5CT4-LysNH2 and T2CT2CT4-LysNH2 and the corresponding targets cloned into pUC 19 were flanked by BamH1, Sal1 or Pstl sites, respectively. In all cases it was found that complete inhibition of restriction enzyme cleavage was obtained...

  19. Definability of restricted theta functions and families of abelian varieties

    CERN Document Server

    Peterzil, Ya'acov

    2011-01-01

    We consider some classical maps from the theory of abelian varieties and their moduli spaces and prove their definability, on restricted domains, in the o-minimal structure $\\Rae$. In particular, we prove that the embedding of moduli space of principally polarized ableian varierty, $Sp(2g,\\Z)\\backslash \\CH_g$, is definable in $\\Rae$, when restricted to Siegel's fundamental set $\\fF_g$. We also prove the definability, on appropriate domains, of embeddings of families of abelian varieties into projective space.

  20. Profiling of micrometer-sized laser beams in restricted volumes

    DEFF Research Database (Denmark)

    Miroshnychenko, Yevhen; Nielsen, Otto; Thorsen, Aske;

    2012-01-01

    micrometers across the measuring volume. We characterize the performance of the method and experimentally demonstrate profiling of micrometer-sized laser beams. We discuss the limiting factors and routes toward a further increase of the resolution and beam profiling in even more restricted volumes. Finally......, as an application example, we present profiling of laser beams inside a micro ion trap with integrated optical fibers.......We present a method for determining the three-dimensional intensity distribution of directed laser radiation with micrometer resolution in restricted volumes. Our method is based on the incoupling and guiding properties of optical fibers, with the current version requiring only a few hundred...

  1. Acute energy restriction triggers Wallerian degeneration in mouse

    DEFF Research Database (Denmark)

    Alvarez, Susana; Moldovan, Mihai; Krarup, Christian

    2008-01-01

    Acute exposure of peripheral axons to the free radical Nitric Oxide (NO) may trigger conduction block and, if prolonged, Wallerian degeneration. It was hypothesized that this neurotoxic effect of NO may be due primarily to energy restriction by inhibition of mitochondrial respiration. We compared......: (i) a transient conduction failure that rapidly normalized within one hour of washout and (ii) subsequent Wallerian degeneration of some axons confirmed at morphological studies. Taken together, these data support the hypothesis that neurotoxicity may be caused by energy restriction. Since...

  2. Restricted use of antibiotics in organic pig farming

    DEFF Research Database (Denmark)

    Aabo, Søren; Jensen, Annette Nygaard

    2013-01-01

    Can the restricted use of antibiotics in organic pig farming be documented to provide a safer, high quality meat product with less antibiotic resistant bacteria? The project SafeOrganic aims to document that the restricted use of antimicrobials in organic pig production leads to lower levels...... of antibiotic resistant bacteria compared with the level in conventional pigs. However, the project will also address the risk of losing this quality parameter, due to a widespread practice of slaughtering organic pigs together with conventional pigs, implying a risk of cross-contamination....

  3. SNP-RFLPing: restriction enzyme mining for SNPs in genomes

    OpenAIRE

    Cheng Yu-Huei; Chang Phei-Lang; Yang Cheng-Hong; Chang Hsueh-Wei; Chuang Li-Yeh

    2006-01-01

    Abstract Background The restriction fragment length polymorphism (RFLP) is a common laboratory method for the genotyping of single nucleotide polymorphisms (SNPs). Here, we describe a web-based software, named SNP-RFLPing, which provides the restriction enzyme for RFLP assays on a batch of SNPs and genes from the human, rat, and mouse genomes. Results Three user-friendly inputs are included: 1) NCBI dbSNP "rs" or "ss" IDs; 2) NCBI Entrez gene ID and HUGO gene name; 3) any formats of SNP-in-se...

  4. Extrauterine growth restriction: Universal problem among premature infants

    Directory of Open Access Journals (Sweden)

    Brunnella Alcantara Chagas de FREITAS

    2016-02-01

    Full Text Available ABSTRACT Objective: To analyze the growth rate of premature infants in the first weeks of life and factors associated with extrauterine growth restriction. Methods: This is a cross-sectional study of 254 premature infants in a neonatal intensive care unit conducted from January 1, 2008 to December 31, 2010. Infants who died or had malformations incompatible with life were excluded. Median weight curves according to gestational age were constructed for the first four weeks of life. The Fenton growth chart calculations provided the weight Z-scores. Extrauterine growth restriction was defined as corrected weight-for-age Z-score ≤-2. Perinatal, morbidity, and health care variables were analyzed. The Poisson regression model yielded the prevalenceratios . Associations between extrauterine growth restriction and the perinatal, morbidity, and care variables were investigated. Poisson regression controlled possible confounding factors. Results: The frequency of extrauterine growth restriction was 24.0%. Most (85.0% small-for-gestational-age infants developed extrauterine growth restriction; 55.3% of extrauterine growth restriction cases involved small-for-gestational-age infants. Premature infants with gestational age >32 weeks did not recover the median birth weight until the third week of life and had a higher frequency of small-for-gestational-age. The Z-scores of non-small-for-gestational-age infants decreased more after birth than those of small-for-gestational-age infants. extrauterine growth restriction was associated with small-for-gestational-age (PR=6.14; 95%CI=3.33-11.33;p <0.001 and time without enteral diet (PR=1.08; 95%CI=1.04-1.13; p =0.010. Conclusion: Extrauterine growth restriction occurs in premature infants of all gestational age. The participation of small-for-gestational-age and nutritional practices in its genesis is noteworthy. We suggest prospective studies of all premature infants. The implementation of best care practices

  5. Human cellular restriction factors that target HIV-1 replication

    OpenAIRE

    Jeang Kuan-Teh; Luban Jeremy; Strebel Klaus

    2009-01-01

    Abstract Recent findings have highlighted roles played by innate cellular factors in restricting intracellular viral replication. In this review, we discuss in brief the activities of apolipoprotein B mRNA-editing enzyme 3G (APOBEC3G), bone marrow stromal cell antigen 2 (BST-2), cyclophilin A, tripartite motif protein 5 alpha (Trim5α), and cellular microRNAs as examples of host restriction factors that target HIV-1. We point to countermeasures encoded by HIV-1 for moderating the potency of th...

  6. Fiducial intervals of restricted parameters and their applications

    Institute of Scientific and Technical Information of China (English)

    LI Xinmin; LI Guoying; XU Xingzhong

    2005-01-01

    In practice, the unknown parameters are often restricted. This paper provides a general method for constructing the fiducial intervals of the restricted parameters. Applying the general method, the fiducial intervals are constructed for the location (scale)parameters and the difference (ratio) of two locations (scales) in a location (scale) family of distributions. The frequency properties of these intervals are verified. For a variance components model, the fiducial intervals for the three parameters of common interest are obtained. Their frequency properties are investigated theoretically and computationally.

  7. Institutional restriction to the trade of fuel materials

    Energy Technology Data Exchange (ETDEWEB)

    Etemad, A. [Vattenfall Fuel, Vaellingby (Sweden); Bay, H. [Nordostschweizerische Kraftwerke AG, Baden (Switzerland)

    1995-12-31

    Very fundamental institutional restrictions have for many years governed for the trade of nuclear material. The NPT and the IAEA Safeguard agreements together with many bilateral or multilateral cooperation agreements have created a stable and over many years predictable working environment for the establishment of the civil nuclear fuel cycle. These restrictions have been very successful as they have resulted in a situation that there is no known diversion of special nuclear material from the civil fuel cycle of NPT member countries to support nuclear weapons programs. (orig./HP)

  8. Restricting factors of the development of SEA in China

    Institute of Scientific and Technical Information of China (English)

    Wang Xianghua; Zhu Xiaodong; LiYangfan; Chen Shanshan

    2006-01-01

    "Environmental Impact Assessment Law of P. R. China" was promulgated on Oct. 28th, 2002 and has been put into effect on Sep 1st, 2003. This paper puts forward some important factors which restrict the development of Strategic Environmental Assessment according to the preliminary practices of SEA in China. These restricting factors are: (1) potential resistance from some departments; (2) poor cooperation between different departments; (3) limited availability of information resources; (4) lack of well-developed SEA methods; (5) difficulties in public participation. The primary thought to solve these problems were proposed at policy and technique level.

  9. Study on modulation techniques free of orthogonality restriction

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The Nyquist rate is a limit of transmission for traditional modulation methods from orthogonality restriction. Nonorthogonal modulation techniques (NMT) is proposed, which removes the orthogonality restriction, and as a result, higher bandwidth efficiency than the traditional methods can be achieved. First, the symbol error rate of NMT is introduced by using estimation theory. Then the relation between bandwidth efficiency and signal to noise ratio is discussed. Finally, a design instance of NMT is present and numerical experiment is made. This study explores for new modulation methods and points out a widened direction for modulation theory and applications.

  10. Semiparametric regression for restricted mean residual life under right censoring

    DEFF Research Database (Denmark)

    Mansourvar, Zahra; Martinussen, Torben; Scheike, Thomas H.

    2015-01-01

    A mean residual life function (MRLF) is the remaining life expectancy of a subject who has survived to a certain time point. In the presence of covariates, regression models are needed to study the association between the MRLFs and covariates. If the survival time tends to be too long or the tail...... is not observed, the restricted mean residual life must be considered. In this paper, we propose the proportional restricted mean residual life model for fitting survival data under right censoring. For inference on the model parameters, martingale estimating equations are developed, and the asymptotic properties...

  11. 17 CFR 1.22 - Use of customer funds restricted.

    Science.gov (United States)

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false Use of customer funds... REGULATIONS UNDER THE COMMODITY EXCHANGE ACT Customers' Money, Securities, and Property § 1.22 Use of customer funds restricted. No futures commission merchant shall use, or permit the use of, the customer funds...

  12. Distribution Learning in Evolutionary Strategies and Restricted Boltzmann Machines

    DEFF Research Database (Denmark)

    Krause, Oswin

    The thesis is concerned with learning distributions in the two settings of Evolutionary Strategies (ESs) and Restricted Boltzmann Machines (RBMs). In both cases, the distributions are learned from samples, albeit with different goals. Evolutionary Strategies are concerned with finding an optimum...

  13. Associations between Schools' Tobacco Restrictions and Adolescents' Use of Tobacco

    Science.gov (United States)

    Oslash-Verland, Simon; Aaro, Leif Edvard; Lindbak, Rita Lill

    2010-01-01

    Schools are an important arena for smoking prevention. In many countries, smoking rates have been reduced among adolescents, but the use of smokeless tobacco is on the rise in some of these countries. We aimed to study the associations between schools' restrictions on smoking and snus and on the use of these tobacco products among students in…

  14. 76 FR 14083 - Proposed Exemptions From Certain Prohibited Transaction Restrictions

    Science.gov (United States)

    2011-03-15

    ... are received, and they can be retrieved by most Internet search engines. The Department will make no..., and in accordance with procedures set forth in 29 CFR part 2570, subpart B (55 FR 32836, 32847, August..., subpart B (55 FR 32836, 32847, August 10, 1990).\\1\\ If the exemption is granted, the restrictions...

  15. Restrictions in social participation of young adults with spina bifida

    NARCIS (Netherlands)

    Barf, H. A.; Post, M. W. M.; Verhoef, M.; Jennekens-Schinkel, A.; Gooskens, R. H. J. M.; Prevo, A. J. H.

    2009-01-01

    Purpose. To determine participation restrictions of young adults with spina bifida (SB) in relation to health condition and activity limitations. Method. A total of 179 persons aged 16-25 years and born with SB participated in a cross-sectional study. The main outcome on four domains of participatio

  16. Designing Intervention Studies: Selected Populations, Range Restrictions, and Statistical Power

    Science.gov (United States)

    Miciak, Jeremy; Taylor, W. Pat; Stuebing, Karla K.; Fletcher, Jack M.; Vaughn, Sharon

    2016-01-01

    An appropriate estimate of statistical power is critical for the design of intervention studies. Although the inclusion of a pretest covariate in the test of the primary outcome can increase statistical power, samples selected on the basis of pretest performance may demonstrate range restriction on the selection measure and other correlated…

  17. Drunkorexia: Calorie Restriction Prior to Alcohol Consumption among College Freshman

    Science.gov (United States)

    Burke, Sloane C.; Cremeens, Jennifer; Vail-Smith, Karen; Woolsey, Conrad

    2010-01-01

    Using a sample of 692 freshmen at a southeastern university, this study examined caloric restriction among students prior to planned alcohol consumption. Participants were surveyed for self-reported alcohol consumption, binge drinking, and caloric intake habits prior to drinking episodes. Results indicated that 99 of 695 (14%) of first year…

  18. 7 CFR 1786.167 - Restrictions to additional RUS financing.

    Science.gov (United States)

    2010-01-01

    ... borrower that has prepaid pursuant to this subpart are in 7 CFR 1717.158. (b) Borrowers that prepay their... 7 Agriculture 12 2010-01-01 2010-01-01 false Restrictions to additional RUS financing. 1786.167... SERVICE, DEPARTMENT OF AGRICULTURE (CONTINUED) PREPAYMENT OF RUS GUARANTEED AND INSURED LOANS TO...

  19. Restricted Interests and Anxiety in Children with Autism

    Science.gov (United States)

    Spiker, Michael A.; Lin, C. Enjey; Van Dyke, Marilyn; Wood, Jeffrey J.

    2012-01-01

    A preoccupation with restricted interests (RI) is a core symptom of autism spectrum disorders (ASD). Engagement in RI is commonly observed in this population and impacts social, adaptive, and emotional functioning. The presence of anxiety disorders and overlap in symptom expression with RI, such as obsessive compulsive disorder (OCD), in children…

  20. 13 CFR 120.383 - Restrictions on loan processing.

    Science.gov (United States)

    2010-01-01

    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Restrictions on loan processing. 120.383 Section 120.383 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION BUSINESS LOANS.... Since greater risk may be associated with a loan to an applicant under this program, a Certified...

  1. 28 CFR 540.15 - Restricted general correspondence.

    Science.gov (United States)

    2010-07-01

    ... restricted general correspondence; (ii) Shall give the inmate the opportunity to respond to the... approved correspondence list, subject to investigation, evaluation, and approval by the Warden; with prior... investigation; and (3) Correspond with former business associates, unless it appears to the Warden that...

  2. 50 CFR 230.6 - Quotas and other restrictions.

    Science.gov (United States)

    2010-10-01

    ... ADMINISTRATION, DEPARTMENT OF COMMERCE WHALING WHALING PROVISIONS § 230.6 Quotas and other restrictions. (a) Quotas for aboriginal subsistence whaling shall be set in accordance with the regulations of the Commission. Quotas shall be allocated to each whaling village or captain by the appropriate Native...

  3. 25 CFR 141.29 - Political contributions restricted.

    Science.gov (United States)

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Political contributions restricted. 141.29 Section 141.29 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR FINANCIAL ACTIVITIES BUSINESS PRACTICES ON THE NAVAJO, HOPI AND ZUNI RESERVATIONS General Business Practices § 141.29 Political...

  4. 34 CFR 76.567 - Other expenditures-restricted rate.

    Science.gov (United States)

    2010-07-01

    ... 34 Education 1 2010-07-01 2010-07-01 false Other expenditures-restricted rate. 76.567 Section 76.567 Education Office of the Secretary, Department of Education STATE-ADMINISTERED PROGRAMS What Conditions Must Be Met by the State and Its Subgrantees? Indirect Cost Rates § 76.567 Other...

  5. Fetal Growth Restriction at the Limits of Viability

    NARCIS (Netherlands)

    Visser, G. H. A.; Bilardo, Caterina M.; Lees, Christopher

    2014-01-01

    The outcome of early small-for-gestational age and/or intrauterine growth-restricted fetuses is reviewed. In these fetuses the outcome appears to be considerably poorer than that of appropriately grown fetuses and this seems mainly to be caused by intrauterine malnutrition rather than by hypoxemia.

  6. 40 CFR 152.168 - Advertising of restricted use products.

    Science.gov (United States)

    2010-07-01

    ... advertised unless the advertisement contains a statement of its restricted use classification. (b) The requirement in paragraph (a) of this section applies to all advertisements of the product, including, but not... of sale or by direct mail. (2) Newspapers, magazines, newsletters and other material in...

  7. Restrictive partially blind signature for resource-constrained information systems

    NARCIS (Netherlands)

    Qiu, Weidong; Gong, Zheng; Liu, Bozhong; Long, Yu; Chen, Kefei

    2010-01-01

    Restrictive partially blind signature, which is designed for privacy oriented information systems, allows a user to obtain a blind signature from a signer whilst the blind message must obey some certain rules. In order to reduce storage and communication costs, several public-key cryptosystems are c

  8. On the restriction of the Fourier transform to polynomial curves

    OpenAIRE

    Dendrinos, S.

    2007-01-01

    We prove a Fourier restriction theorem on curves parametrised by the mapping P(t) = (P1(t),..., Pn(t)), where each of the P1,..., Pn is a real-valued polynomial and t belongs to an interval on which each of the P1,..., Pn "resembles" a monomial.

  9. 50 CFR 635.40 - Restrictions to enhance conservation.

    Science.gov (United States)

    2010-10-01

    ... by the declaration(s) required by 19 CFR 10.79. The “Declaration of Master and Two Members of Crew on Entry of Products of American Fisheries” required by 19 CFR 10.79 must contain a further statement as... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Restrictions to enhance conservation....

  10. 5 CFR 1304.4605 - Post-employment restrictions.

    Science.gov (United States)

    2010-01-01

    .... The government employee is also restricted from making any oral or written communication to an agency... two years from making any oral or written communication to any agency with the intent to influence on... or representing himself, either by appearance before an agency or through communication with...

  11. Differentially Private Data Analysis of Social Networks via Restricted Sensitivity

    CERN Document Server

    Blocki, Jeremiah; Datta, Anupam; Sheffet, Or

    2012-01-01

    We introduce the notion of restricted sensitivity as an alternative to global and smooth sensitivity to improve accuracy in differentially private data analysis. The definition of restricted sensitivity is similar to that of global sensitivity except that instead of quantifying over all possible datasets, we take advantage of any beliefs about the dataset that a querier may have, to quantify over a restricted class of datasets. Specifically, given a query f and a hypothesis H about the structure of a dataset D, we show generically how to transform f into a new query f_H whose global sensitivity (over all datasets including those that do not satisfy H) matches the restricted sensitivity of the query f. Moreover, if the belief of the querier is correct (i.e., D is in H) then f_H(D) = f(D). If the belief is incorrect, then f_H(D) may be inaccurate. We demonstrate the usefulness of this notion by considering the task of answering queries regarding social-networks, which we model as a combination of a graph and a ...

  12. Kamm on Inviolability and Agent-Relative Restrictions

    DEFF Research Database (Denmark)

    Lippert-Rasmussen, Kasper

    2009-01-01

    Abstract  Agent-relative restrictions prohibit minimizing violations: that is, they require us not to minimize the total number of their violations by violating them ourselves. Frances Kamm has explained this prohibition in terms of the moral worth of persons, which, in turn, she explains in terms...

  13. Proposal of Realization Restricted Quantum Game with Linear Optic Method

    Institute of Scientific and Technical Information of China (English)

    ZHAO Hai-Jun; FANG Xi-Ming

    2006-01-01

    We present a quantum game with the restricted strategic space and its realization with linear optical system, which can be played by two players who are separated remotely. This game can also be realized on any other quantum computers. We find that the constraint brings some interesting properties that are useful for making game models.

  14. The political economy of structural reforms under a deficit restriction

    NARCIS (Netherlands)

    M.P. Ribeiro; R. Beetsma

    2008-01-01

    This paper analyzes the incentives of a government facing electoral uncertainty to implement structural reforms in the presence of a deficit restriction. In designing a reform package, the government faces a trade-off between enhancing its electoral chances by providing compensation to private indiv

  15. 76 FR 34253 - Exemptions From Certain Prohibited Transaction Restrictions

    Science.gov (United States)

    2011-06-13

    ... lodging and meals by the Plan to the International Union of Painters and Allied Trades, AFL-CIO (the Union... prohibited transaction restrictions of the Employee Retirement Income Security Act of 1974 (ERISA or the Act... (the Plan) and H.E. Butt Grocery Company (the Company); L-11625, 2011-12, The International Union...

  16. Low temperature attenuation of sound in restricted geometries

    OpenAIRE

    Lambert, B.; Salin, D.

    1980-01-01

    We have measured the low temperature attenuation of sound at 1 GHz in liquid helium confined in the pores of Vycor glass; our data clearly show the one-dimensional behaviour of the normal density in this restricted geometry; the experimental value is in agreement with fourth sound measurements; anyway the experimental values are three orders of magnitude larger than the theoretical one.

  17. 77 FR 65840 - Chrysanthemum White Rust Regulatory Status and Restrictions

    Science.gov (United States)

    2012-10-31

    ...; ] DEPARTMENT OF AGRICULTURE Animal and Plant Health Inspection Service 7 CFR Part 319 RIN 0579-AD67 Chrysanthemum White Rust Regulatory Status and Restrictions AGENCY: Animal and Plant Health Inspection Service... chrysanthemum white rust (CWR) outbreaks and the importation of plant material that is a host of CWR. CWR is...

  18. 77 FR 46339 - Chrysanthemum White Rust Regulatory Status and Restrictions

    Science.gov (United States)

    2012-08-03

    ...; ] DEPARTMENT OF AGRICULTURE Animal and Plant Health Inspection Service 7 CFR Part 319 RIN 0579-AD67 Chrysanthemum White Rust Regulatory Status and Restrictions AGENCY: Animal and Plant Health Inspection Service... chrysanthemum white rust (CWR) outbreaks and the importation of plant material that is a host of...

  19. 75 FR 20796 - Market-Based Rate Affiliate Restrictions

    Science.gov (United States)

    2010-04-21

    ... requires that, as a condition of receiving and retaining market-based rate authority, sellers comply with...-based rate sellers to share employees that may not currently be shared under the affiliate restrictions... requirements for market-based rate sellers were approved under FERC-919 ``Market-Based Rates for...

  20. 40 CFR 35.6575 - Restrictions on types of contracts.

    Science.gov (United States)

    2010-07-01

    ... ASSISTANCE STATE AND LOCAL ASSISTANCE Cooperative Agreements and Superfund State Contracts for Superfund... contracts. (b) Removal. Under a removal Cooperative Agreement, the recipient must award a fixed-price... 40 Protection of Environment 1 2010-07-01 2010-07-01 false Restrictions on types of contracts....

  1. Sleep Restriction Worsens Mood and Emotion Regulation in Adolescents

    Science.gov (United States)

    Baum, Katherine T.; Desai, Anjali; Field, Julie; Miller, Lauren E.; Rausch, Joseph; Beebe, Dean W.

    2014-01-01

    Background: The relationship between inadequate sleep and mood has been well-established in adults and is supported primarily by correlational data in younger populations. Given that adolescents often experience shortened sleep on school nights, we sought to better understand the effect of experimentally induced chronic sleep restriction on…

  2. Evaluation of Feeding Torerance in Intrauterine Growth Restricted Preterm Infants

    NARCIS (Netherlands)

    Bozzetti, V.

    2016-01-01

    Intra Uterine Growth Restriction (IUGR) is an important and common problem in obstetrics. The purpose of the present thesis was to investigate: 1. Feeding issues in IUGR preterm infants; 2. Clinical and strumental parameters as predictors of feeding tolerance in IUGR preterm infants; 3. Splanchnic a

  3. Testing exclusion restrictions and additive separability in sample selection models

    DEFF Research Database (Denmark)

    Huber, Martin; Mellace, Giovanni

    2014-01-01

    Standard sample selection models with non-randomly censored outcomes assume (i) an exclusion restriction (i.e., a variable affecting selection, but not the outcome) and (ii) additive separability of the errors in the selection process. This paper proposes tests for the joint satisfaction of these......Standard sample selection models with non-randomly censored outcomes assume (i) an exclusion restriction (i.e., a variable affecting selection, but not the outcome) and (ii) additive separability of the errors in the selection process. This paper proposes tests for the joint satisfaction...... of these assumptions by applying the approach of Huber and Mellace (Testing instrument validity for LATE identification based on inequality moment constraints, 2011) (for testing instrument validity under treatment endogeneity) to the sample selection framework. We show that the exclusion restriction and additive...... separability imply two testable inequality constraints that come from both point identifying and bounding the outcome distribution of the subpopulation that is always selected/observed. We apply the tests to two variables for which the exclusion restriction is frequently invoked in female wage regressions: non...

  4. Development of adherence metrics for caloric restriction interventions

    Science.gov (United States)

    Objective measures are needed to quantify dietary adherence during caloric restriction (CR) while participants are freeliving. One method to monitor adherence is to compare observed weight loss to the expected weight loss during a prescribed level of CR. Normograms (graphs)of expected weight loss ca...

  5. Development of adherence metrics for caloric restriction interventions

    Science.gov (United States)

    Objective measures are needed to quantify dietary adherence during caloric restriction (CR) while participants are freeliving. One method to monitor adherence is to compare observed weight loss to the expected weight loss during a prescribed level of CR. Normograms (graphs) of expected weight loss c...

  6. Data Input and Content Exploration in Scenarios with Restrictions

    NARCIS (Netherlands)

    Pedrosa, D.C.

    2014-01-01

    As technology evolves, new devices and interaction techniques are developed. These transformations create several challenges in terms of usability and user experience. Our research faces some challenges for data input or content exploration in scenarios with restrictions. It is not our intention to

  7. Phenylketonuria : tyrosine supplementation in phenylalanine-restricted diets

    NARCIS (Netherlands)

    van Spronsen, FJ; van Rijn, M; Bekhof, J; Koch, R; Smit, PGA

    2001-01-01

    Treatment of phenylketonuria (PKU) consists of restriction of natural protein and provision of a protein substitute that lacks phenylalanine but is enriched in tyrosine. Large and unexplained differences exist, however, in the tyrosine enrichment of the protein substitutes. Furthermore, some investi

  8. RESTRICTIONS GROWING ON PHYSICIAN SPEECH IN EXAM ROOM.

    Science.gov (United States)

    Martin, John G; Difiore, Michael G; Sonpal, Jessica F

    2014-11-25

    An open relationship between physician and patient is crucial to good healthcare. But are there limits to what physicians can ask their patients? Laws restricting doctors' freedom to discuss certain topics with patients, enacted primarily to promote a particular political viewpoint, are nothing new. Still, physicians must be mindful of this troubling trend. PMID:26242068

  9. A whole genome screen for HIV restriction factors

    Directory of Open Access Journals (Sweden)

    Liu Li

    2011-11-01

    Full Text Available Abstract Background Upon cellular entry retroviruses must avoid innate restriction factors produced by the host cell. For human immunodeficiency virus (HIV human restriction factors, APOBEC3 (apolipoprotein-B-mRNA-editing-enzyme, p21 and tetherin are well characterised. Results To identify intrinsic resistance factors to HIV-1 replication we screened 19,121 human genes and identified 114 factors with significant inhibition of infection. Those with a known function are involved in a broad spectrum of cellular processes including receptor signalling, vesicle trafficking, transcription, apoptosis, cross-nuclear membrane transport, meiosis, DNA damage repair, ubiquitination and RNA processing. We focused on the PAF1 complex which has been previously implicated in gene transcription, cell cycle control and mRNA surveillance. Knockdown of all members of the PAF1 family of proteins enhanced HIV-1 reverse transcription and integration of provirus. Over-expression of PAF1 in host cells renders them refractory to HIV-1. Simian Immunodeficiency Viruses and HIV-2 are also restricted in PAF1 expressing cells. PAF1 is expressed in primary monocytes, macrophages and T-lymphocytes and we demonstrate strong activity in MonoMac1, a monocyte cell line. Conclusions We propose that the PAF1c establishes an anti-viral state to prevent infection by incoming retroviruses. This previously unrecognised mechanism of restriction could have implications for invasion of cells by any pathogen.

  10. Temi firthiani di linguistica applicata: "Restricted Languages" e "Collocation" (Firthian Themes in Applied Linguistics: "Restricted Languages" and "Collocation")

    Science.gov (United States)

    Leonardi, Magda

    1977-01-01

    Discusses the importance of two Firthian themes for language teaching. The first theme, "Restricted Languages," concerns the "microlanguages" of every language (e.g., literary language, scientific, etc.). The second theme, "Collocation," shows that equivalent words in two languages rarely have the same position in both languages. (Text is in…

  11. Intracellular diffusion restrictions in isolated cardiomyocytes from rainbow trout

    Directory of Open Access Journals (Sweden)

    Birkedal Rikke

    2009-12-01

    Full Text Available Abstract Background Restriction of intracellular diffusion of adenine nucleotides has been studied intensively on adult rat cardiomyocytes. However, their cause and role in vivo is still uncertain. Intracellular membrane structures have been suggested to play a role. We therefore chose to study cardiomyocytes from rainbow trout (Oncorhynchus mykiss, which are thinner and have fewer intracellular membrane structures than adult rat cardiomyocytes. Previous studies suggest that trout permeabilized cardiac fibers also have diffusion restrictions. However, results from fibers may be affected by incomplete separation of the cells. This is avoided when studying permeabilized, isolated cardiomyocytes. The aim of this study was to verify the existence of diffusion restrictions in trout cardiomyocytes by comparing ADP-kinetics of mitochondrial respiration in permeabilized fibers, permeabilized cardiomyocytes and isolated mitochondria from rainbow trout heart. Experiments were performed at 10, 15 and 20°C in the absence and presence of creatine. Results Trout cardiomyocytes hypercontracted in the solutions used for mammalian cardiomyocytes. We developed a new solution in which they retained their shape and showed stable steady state respiration rates throughout an experiment. The apparent ADP-affinity of permeabilized cardiomyocytes was different from that of fibers. It was higher, independent of temperature and not increased by creatine. However, it was still about ten times lower than in isolated mitochondria. Conclusions The differences between fibers and cardiomyocytes suggest that results from trout heart fibers were affected by incomplete separation of the cells. However, the lower ADP-affinity of cardiomyocytes compared to isolated mitochondria indicate that intracellular diffusion restrictions are still present in trout cardiomyocytes despite their lower density of intracellular membrane structures. The lack of a creatine effect indicates that

  12. Accelerate Monte Carlo Simulations with Restricted Boltzmann Machines

    CERN Document Server

    Huang, Li

    2016-01-01

    Despite their exceptional flexibility and popularity, the Monte Carlo methods often suffer from slow mixing times for challenging statistical physics problems. We present a general strategy to overcome this difficulty by adopting ideas and techniques from the machine learning community. We fit the unnormalized probability of the physical model to a feedforward neural network and reinterpret the architecture as a restricted Boltzmann machine. Then, exploiting its feature detection ability, we utilize the restricted Boltzmann machine for efficient Monte Carlo updates and to speed up the simulation of the original physical system. We implement these ideas for the Falicov-Kimball model and demonstrate improved acceptance ratio and autocorrelation time near the phase transition point.

  13. Cosmological Perturbations in Restricted f(R)-Gravity

    CERN Document Server

    Chaichian, M; Kluson, J

    2016-01-01

    We investigate the metric perturbations of the restricted f(R) theory of gravity in the cosmological context and explore the phenomenological implications of this model. We show that it is possible to construct a restricted model of gravity, in which the background equations are the same as the equations of motion which are derived from the Einstein-Hilbert action with the cosmological constant term. We argue that the deviation from the Einstein-Hilbert model emerges in the perturbed equations, for which we have a non-vanishing anisotropic stress. Further, with the help of the results of Planck data for the modified gravity we obtain constraints on the parameters of the model.

  14. Insights into restrictive cardiomyopathy from clinical and animal studies

    Institute of Scientific and Technical Information of China (English)

    Pierre-Yves Jean-Charles; Yue-Jin Li; Chang-Long Nan; Xu-Pei Huang

    2011-01-01

    Catdiomyopathies are diseases that primarily affect the myocardium,leading to serious cardiac dysfimction and heart failure.Out of the three major categories of candiomyopathies(hypertrophic,dilated and restrictive),restrictive cardiomyopathy(RCM)is less common and also the least studied However,the prognosis for RCM is poor as some patients dying in their childhood The molecular mechanisms behind the disease development and progression are not very clear and the treatment of RCM is very difficult and often ineffective.In this article,we reviewed the recent progress in RCM research from the clinical studies and the translational studies done on diseased transgenic animal models.This will help for a better understanding of tare mechanisms underlying the etiology and development of RCM and for the design of better treatments for the disease.

  15. Restrictive extraocular myopathy: A presenting feature of acromegaly

    Directory of Open Access Journals (Sweden)

    Steven Heireman

    2011-01-01

    Full Text Available A 45-year-old man presented with binocular diplopia in primary gaze for 1 year. Orthoptic evaluation showed 10-prism diopter right eye hypotropia and 6-prism diopter right eye esotropia. The elevation and abduction of the right eye were mechanically restricted. This was associated with systemic features suggestive of acromegaly. Magnetic resonance imaging (MRI of the brain demonstrated a pituitary macroadenoma. An elevated serum insulin-like growth factor I level and the failure of growth hormone suppression after an oral glucose load biochemically confirmed the diagnosis of acromegaly. Computed tomography (CT of the orbit demonstrated bilateral symmetrical enlargement of the medial rectus and inferior rectus muscle bellies. All tests regarding Graves-Basedow disease were negative. Although rare, diplopia due to a restrictive extraocular myopathy could be the presenting symptom of acromegaly.

  16. Growth restriction effects during solidification of aluminium alloys

    Institute of Scientific and Technical Information of China (English)

    CHEN Zhong-wei; HE Zhi; JIE Wan-qi

    2009-01-01

    The effects of solute elements during solidification on the grain size are very important and can be quantified by the growth-restriction parameter Q, and Q possesses the better correlation with the grain size. Based on the constitutional undercooling generated by the growth of an adjacent grain during the initial solidification, the growth-restriction parameter Q is deduced and a comprehensive physical basis of Q is obtained by using an initial solute distributing equation. For the alloys with more potent nucleants, Q is a suitable predictor of the grain size. For less potent nucleants, the relative grain size(RGS) is a more accurate prediction of the grain size. This prediction coincides with the experimental behaviors for Al-Ti and Al-Cu alloys with lower solute content.

  17. DOE Land Disposal Restrictions strategy report for radioactive mixed waste

    International Nuclear Information System (INIS)

    This report is based on preliminary information available at the time of the Land Disposal Restrictions (LDR) Strategy Workshop in June 1989, and the critical review of the workshop data conducted by the Office Of Defense Programs and the affected Operations Offices in July and August 1989. The purpose of the workshop and this subsequent report is to identify the magnitude and scope of LDR issues and impacts regarding the storage, treatment, and disposal of RMW, and to suggest potential strategies for addressing LDR requirements. This report was prepared under the overall direction and coordination of the Department of Energy (DOE) Headquarters Environmental Guidance Division, RCRA/CERCLA Unit (EH-231). The report is a product of the LDR Strategy Workshop held during the month of June 1989. The workshop was divided into two work groups: a Land Disposal Restriction compliance strategy group and a RMW Best Demonstrated Available Technology and National Capacity Variance group

  18. Restriction of Retroviral Replication by Tetherin/BST-2

    Directory of Open Access Journals (Sweden)

    Jason Hammonds

    2012-01-01

    Full Text Available Tetherin/BST-2 is an important host restriction factor that limits the replication of HIV and other enveloped viruses. Tetherin is a type II membrane glycoprotein with a very unusual domain structure that allows it to engage budding virions and retain them on the plasma membrane of infected cells. Following the initial report identifying tetherin as the host cell factor targeted by the HIV-1 Vpu gene, knowledge of the molecular, structural, and cellular biology of tetherin has rapidly advanced. This paper summarizes the discovery and impact of tetherin biology on the HIV field, with a focus on recent advances in understanding its structure and function. The relevance of tetherin to replication and spread of other retroviruses is also reviewed. Tetherin is a unique host restriction factor that is likely to continue to provide new insights into host-virus interactions and illustrates well the varied ways by which host organisms defend against viral pathogens.

  19. The effect of quantum noise on the restricted quantum game

    Institute of Scientific and Technical Information of China (English)

    Cao Shuai; Fang Mao-Fa

    2006-01-01

    It has recently been established that quantum strategies have great advantage over classical ones in quantum games. However, quantum states are easily affected by the quantum noise resulting in decoherence. In this paper, we investigate the effect of quantum noise on the restricted quantum game in which one player is restricted in classical strategic space, another in quantum strategic space and only the quantum player is affected by the quantum noise. Our results show that in the maximally entangled state, no Nash equilibria exist in the range of 0< p≤0.422 (p is the quantum noise parameter), while two special Nash equilibria appear in the range of 0.422 < p< 1. The advantage that the quantum player diminished only in the limit of maximum quantum noise. Increasing the amount of quantum noise leads to the increase of the classical player's payoff and the reduction of the quantum player's payoff, but is helpful in forming two Nash equilibria.

  20. Generating families in the restricted three-body problem

    CERN Document Server

    Hénon, Michel

    The classical restricted three-body problem is of fundamental importance because of its applications in astronomy and space navigation, and also as a simple model of a non-integrable Hamiltonian dynamical system. A central role is played by periodic orbits, of which many have been computed numerically. This is the second volume of an attempt to explain and organize the material through a systematic study of generating families, the limits of families of periodic orbits when the mass ratio of the two main bodies becomes vanishingly small. We use quantitative analysis in the vicinity of bifurcations of types 1 and 2. In most cases the junctions between branches can now be determined. A first-order approximation of families of periodic orbits in the vicinity of a bifurcation is also obtained. This book is intended for scientists and students interested in the restricted problem, in its applications to astronomy and space research, and in the theory of dynamical systems.

  1. Identification of beef using restriction fragment length polymorphism–

    Directory of Open Access Journals (Sweden)

    R. A. Al-Sanjary

    2009-01-01

    Full Text Available To differentiate the beef from other types of meat consumed by human, DNA markers based on polymerase chain reaction restriction fragment length polymorphism technique is performed by using universal primers designed on mitochondrial cytochrome b gene to obtain amplified band 359 bp, then digested with some of restriction enzymes like Tru91, RsaI, Hinf I, Hae III, Alu I, Taq I, Mob I. The result revealed that, the Hinf I enzyme produce three bands 198, 117, 44 bp and the Hae III enzyme revealed two band 285, 74 bp, the Alu I enzyme also produced two band but the molecular weight are 190, 169 bp. The other enzymes did not reveal any digestion of the amplified bands and this result is a characteristic unique to beef compared with other types of meat when using same enzymes.

  2. Kinematic and temperature restrictions on the electron cyclotron maser instability

    International Nuclear Information System (INIS)

    The ranges of temperature T, harmonic number s and wave propagation angle THETA in which the loss-cone-driven electron cyclotron instability can exist are found to be limited by opposing contributions to the growth rate from adjacent harmonics. For waves with refractive index n approx. = to 1 it is found that instability is possible only if T and s satisfy ssup(a)T approx. = to C with a 2 - 2.5 and where the constant C is determined by THETA and the form of the distribution function. It is argued that the corresponding restrictions for waves with very large or very small n are less severe. Instability is found to be forbidden for waves propagating outside a range |THETA-900| 2phi(s) approx. = s-1; this restriction limits the range of potentially unstable frequencies at a given harmonic. (author)

  3. Non-placental causes of intrauterine growth restriction.

    Science.gov (United States)

    Hendrix, Nancy; Berghella, Vincenzo

    2008-06-01

    Placental insufficiency, in some form or fashion, is associated with the majority of cases of intrauterine growth restriction (IUGR). There are numerous causes of IUGR which are not caused primarily by placental insufficiency, but indirectly lead to it. The causes of IUGR can be subdivided into fetal and maternal etiologies. The fetal etiologies consist of genetic diseases, congenital malformations, infections, multiple gestations, and placental/cord abnormalities. The maternal etiologies are categorized as follows: (1) decreased uteroplacental blood flow, (2) reduced blood volume, (3) decreased oxygen carrying capacity, (4) nutrition status, (5) teratogens, and (6) miscellaneous causes such as short interpregnancy intervals, race, maternal age, and low socioeconomic status. Knowledge of the etiologies of fetal growth restriction is essential, so that future care can be targeted at prevention. There are several primary and secondary prevention strategies that can be adopted.

  4. RESTRICTED NONLINEAR APPROXIMATION AND SINGULAR SOLUTIONS OF BOUNDARY INTEGRAL EQUATIONS

    Institute of Scientific and Technical Information of China (English)

    Reinhard Hochmuth

    2002-01-01

    This paper studies several problems, which are potentially relevant for the construction of adaptive numerical schemes. First, biorthogonal spline wavelets on [0,1 ] are chosen as a starting point for characterizations of functions in Besov spaces B , (0,1) with 0<σ<∞ and (1+σ)-1<τ<∞. Such function spaces are known to be related to nonlinear approximation. Then so called restricted nonlinear approximation procedures with respect to Sobolev space norms are considered. Besides characterization results Jackson type estimates for various tree-type and tresholding algorithms are investigated. Finally known approximation results for geometry induced singularity functions of boundary integeral equations are combined with the characterization results for restricted nonlinear approximation to show Besov space regularity results.

  5. Calorie Restriction in Mammals and Simple Model Organisms

    Directory of Open Access Journals (Sweden)

    Giusi Taormina

    2014-01-01

    Full Text Available Calorie restriction (CR, which usually refers to a 20–40% reduction in calorie intake, can effectively prolong lifespan preventing most age-associated diseases in several species. However, recent data from both human and nonhumans point to the ratio of macronutrients rather than the caloric intake as a major regulator of both lifespan and health-span. In addition, specific components of the diet have recently been identified as regulators of some age-associated intracellular signaling pathways in simple model systems. The comprehension of the mechanisms underpinning these findings is crucial since it may increase the beneficial effects of calorie restriction making it accessible to a broader population as well.

  6. Calorie restriction in mammals and simple model organisms.

    Science.gov (United States)

    Taormina, Giusi; Mirisola, Mario G

    2014-01-01

    Calorie restriction (CR), which usually refers to a 20-40% reduction in calorie intake, can effectively prolong lifespan preventing most age-associated diseases in several species. However, recent data from both human and nonhumans point to the ratio of macronutrients rather than the caloric intake as a major regulator of both lifespan and health-span. In addition, specific components of the diet have recently been identified as regulators of some age-associated intracellular signaling pathways in simple model systems. The comprehension of the mechanisms underpinning these findings is crucial since it may increase the beneficial effects of calorie restriction making it accessible to a broader population as well. PMID:24883306

  7. Evaluating the economic cost of natural gas strategic storage restrictions

    International Nuclear Information System (INIS)

    The European Commission wants to implement a single market for gas. One of the components of this market is a regulated provision for ''security of supply'' which consists of rules for the implementation and use of a given reserve stock of gas. We investigate the impact of this policy on the profitability of a storage operator, using data from Denmark and Italy. Keeping storage capacity constant, the costs of the strategic stock are around 20% of the value of the storage market for Denmark, and 16% for Italy. This cost is due to the inability to extract arbitrage profits from the captive stock. Furthermore, the strategic storage restriction induces behavior that would virtually never be replicated by a private storage operator in an unconstrained market, in particular in the first 6 months of the year when unconstrained firms empty their reservoirs much faster, suggesting the strategic restriction is unnecessarily distorting the market. (author)

  8. Restrictive versus liberal transfusion strategy for red blood cell transfusion

    DEFF Research Database (Denmark)

    Holst, Lars B; Petersen, Marie W; Haase, Nicolai;

    2015-01-01

    OBJECTIVE: To compare the benefit and harm of restrictive versus liberal transfusion strategies to guide red blood cell transfusions. DESIGN: Systematic review with meta-analyses and trial sequential analyses of randomised clinical trials. DATA SOURCES: Cochrane central register of controlled...... trials, SilverPlatter Medline (1950 to date), SilverPlatter Embase (1980 to date), and Science Citation Index Expanded (1900 to present). Reference lists of identified trials and other systematic reviews were assessed, and authors and experts in transfusion were contacted to identify additional trials....... TRIAL SELECTION: Published and unpublished randomised clinical trials that evaluated a restrictive compared with a liberal transfusion strategy in adults or children, irrespective of language, blinding procedure, publication status, or sample size. DATA EXTRACTION: Two authors independently screened...

  9. Bell inequality for pairs of superselection rule restricted states

    CERN Document Server

    Heaney, Libby; Jaksch, Dieter

    2010-01-01

    Proposals for Bell inequality tests on systems restricted by superselection rules often require operations that are difficult to implement in practice. In this paper, we derive a new Bell inequality, where pairs of states are used to by-pass the superselection rule. In particular, we focus on mode entanglement of an arbitrary number of massive particles and show that our Bell inequality detects the entanglement in the pair when other inequalities fail. However, as the number of particles in the system increases, the violation of our Bell inequality decreases due to the restriction in the measurement space caused by the superselection rule. This Bell test can be implemented using techniques that are routinely used in current experiments.

  10. Some restrictions on the existence of second order limit language

    Science.gov (United States)

    Ahmad, Muhammad Azrin; Sarmin, Nor Haniza; Yusof, Yuhani; Fong, Wan Heng

    2015-10-01

    The cut and paste phenomenon on DNA molecules with the presence of restriction enzyme and appropriate ligase has led to the formalism of mathematical modelling of splicing system. A type of splicing system named Yusof-Goode splicing system is used to present the transparent behaviour of the DNA splicing process. The limit language that is defined as the leftover molecules after the system reaches its equilibrium point has been extended to a second order limit language. The non-existence of the second order limit language biologically has lead to this study by using mathematical approach. In this paper, the factors that restrict the formation of the second order limit language are discussed and are presented as lemmas and theorem using Y-G approach. In addition, the discussion focuses on Yusof- Goode splicing system with at most two initial strings and two rules with one cutting site and palindromic crossing site and recognition sites.

  11. MARTINDALE'S DRUGS RESTRICTED IN SPORT POCKET COMPANION 2009

    Directory of Open Access Journals (Sweden)

    Sean C. Sweetman

    2009-06-01

    Full Text Available Over 500 drugs restricted in sport presented in alphabetical order. To inform and alert the athlete about the potential problem of drug taking for any kind of reasons on and off during training and competition.A comprehensive index of drug names, synonyms, medical usage, single and multi-ingredient preparations and trade (on occasion street names of drugs from 40 countries worldwide (Martindale data. The classification of World Anti-Doping Agency (WADA is added to the explanation of drugs limitation in sport in and out of competition. A glossary of common medical terms is also included.This pocket publication is a must-have list of restricted drugs for athletes, trainers, sports medicine professionals, in short for anyone in exercise physiology and human performance fields.

  12. Effects of restriction on children’s intake differ by child temperament, food reinforcement, and parent’s chronic use of restriction.

    Science.gov (United States)

    Rollins, Brandi Y; Loken, Eric; Savage, Jennifer S; Birch, Leann L

    2014-02-01

    Parents’ use of restrictive feeding practices is counterproductive, increasing children’s intake of restricted foods and risk for excessive weight gain. The aims of this research were to replicate Fisher and Birch’s (1999b) original findings that short-term restriction increases preschool children’s (3–5 y) selection, intake, and behavioral response to restricted foods, and to identify characteristics of children who were more susceptible to the negative effects of restriction. The experiment used a within-subjects design; 37 children completed the food reinforcement task and heights/weights were measured. Parents reported on their use of restrictive feeding practices and their child’s inhibitory control and approach. Overall, the findings replicated those of and revealed that the effects of restriction differed by children’s regulatory and appetitive tendencies. Greater increases in intake in response to restriction were observed among children lower in inhibitory control, higher in approach, who found the restricted food highly reinforcing, and who had previous experience with parental use of restriction. Results confirm that the use of restriction does not reduce children’s consumption of these foods, particularly among children with lower regulatory or higher appetitive tendencies.

  13. ON THE COEFFICIENTS OF A POLYNOMIAL WITH RESTRICTED ZEROS

    Institute of Scientific and Technical Information of China (English)

    A.Aziz; W.M.Shah

    2009-01-01

    LetP(Z)=αn Zn + αn-1Zn-1 +…+α0 be a complex polynomial of degree n. There is a close connection between the coefficients and the zeros of P(z). In this paper we prove some sharp inequalities concerning the coeffi-cients of the polynomial P(z) with restricted zeros. We also establish a sufficient condition for the separation of zeros of P(z).

  14. Activity restriction in mild COPD: a challenging clinical problem

    OpenAIRE

    DE O'Donnell; Gebke KB

    2014-01-01

    Denis E O'Donnell,1 Kevin B Gebke2 1Division of Respiratory and Critical Care Medicine, Respiratory Investigation Unit, Queen's University and Kingston General Hospital, Kingston, ON, Canada; 2Primary Care Sports Medicine Program, Indiana University School of Medicine, Indianapolis, IN, USA Abstract: Dyspnea, exercise intolerance, and activity restriction are already apparent in mild chronic obstructive pulmonary disease (COPD). However, patients may not seek medical help unt...

  15. Martindale’s Drugs Restricted in Sport Pocket Companion 2009

    OpenAIRE

    Sweetman, Sean C

    2009-01-01

    Over 500 drugs restricted in sport presented in alphabetical order. To inform and alert the athlete about the potential problem of drug taking for any kind of reasons on and off during training and competition.A comprehensive index of drug names, synonyms, medical usage, single and multi-ingredient preparations and trade (on occasion street) names of drugs from 40 countries worldwide (Martindale data). The classification of World Anti-Doping Agency (WADA) is added to the explanation of drugs ...

  16. Restricted Dynamic Programming Heuristic for Precedence Constrained Bottleneck Generalized TSP

    OpenAIRE

    Salii, Y.

    2015-01-01

    We develop a restricted dynamical programming heuristic for a complicated traveling salesman problem: a) cities are grouped into clusters, resp. Generalized TSP; b) precedence constraints are imposed on the order of visiting the clusters, resp. Precedence Constrained TSP; c) the costs of moving to the next cluster and doing the required job inside one are aggregated in a minimax manner, resp. Bottleneck TSP; d) all the costs may depend on the sequence of previously visited clusters, resp. Seq...

  17. Endonuclease specificity and sequence dependence of Type IIS restriction enzymes

    OpenAIRE

    Lundin, Sverker; Finn, Terje-Hegge; Foam, Napoleon; Pettersson, Erik; Käller, Max; Wirta, Valtteri; Lexow, Preben; Lundeberg, Joakim

    2015-01-01

    Restriction enzymes that recognize specific sequences but cleave unknown sequence outside the recognition site are extensively utilized tools in molecular biology. Despite this, systematic functional categorization of cleavage performance has largely been lacking. We established a simple and automatable model system to assay cleavage distance variation (termed slippage) and the sequence dependence thereof. We coupled this to massively parallel sequencing in order to provide sensitive and accu...

  18. The surgical treatment of restrictive cardiomyopathy in pseudoxanthoma elasticum.

    OpenAIRE

    Challenor, V F; Conway, N.; Monro, J L

    1988-01-01

    A patient with pseudoxanthoma elasticum presented in pulmonary oedema with restrictive left ventricular cardiomyopathy caused by calcified endocardial bands that were confirmed on echocardiography and at catheterisation. The bands were resected as far as possible and the involved mitral valve was replaced by a heterograft. A year later calcification of the heterograft forced its replacement by a St Jude prosthesis. Relief of symptoms has been good in the medium term.

  19. Coupling strength estimation for spin chains despite restricted access

    OpenAIRE

    Burgarth, Daniel; Maruyama, Koji; Nori, Franco

    2008-01-01

    Quantum control requires full knowledge of the system many-body Hamiltonian. In many cases this information is not directly available due to restricted access to the system. Here we show how to indirectly estimate all the coupling strengths in a spin chain by measuring one spin at the end of the chain. We also discuss the efficiency of this "quantum inverse problem" and give a numerical example.

  20. Controlling the enzymatic activity of a restriction enzyme by light

    OpenAIRE

    Schierling, Benno; Noël, Ann-Josée; Wende, Wolfgang; Hien, Le Thi; Volkov, Eugeny; Kubareva, Elena; Oretskaya, Tatiana; Kokkinidis, Michael; Römpp, Andreas; Spengler, Bernhard; Pingoud, Alfred

    2009-01-01

    For many applications it would be desirable to be able to control the activity of proteins by using an external signal. In the present study, we have explored the possibility of modulating the activity of a restriction enzyme with light. By cross-linking two suitably located cysteine residues with a bifunctional azobenzene derivative, which can adopt a cis- or trans-configuration when illuminated by UV or blue light, respectively, enzymatic activity can be controlled in a reversible manner. T...

  1. Monetary Policy Neutrality: Sign Restrictions Go to Monte Carlo.

    OpenAIRE

    Efrem Castelnuovo

    2012-01-01

    A new-Keynesian DSGE model in which contractionary monetary policy shocks generate recessions is estimated with U.S. data. It is then used in a Monte Carlo exercise to generate artificial data with which VARs are estimated. VAR monetary policy shocks are identified via sign restrictions. Our VAR impulse responses replicate UhligÕs (2005, Journal of Monetary Economics) evidence on unexpected interest rate hikes having ambiguous effects on output. The mismatch between the true (DSGE-consistent)...

  2. Data Dispersion in Economics (I) --- Possibility of Restrictions

    OpenAIRE

    Alexander Harin

    2012-01-01

    The article is devoted to data dispersion in economics. The state of the art and the problems of the utility theory are briefly reviewed. Examples of typical paradoxes, which are analyzed by the utility theory, are given. Analogous paradoxes may concern problems such as the underweighting of high and the overweighting of low probabilities, risk aversion, the equity premium puzzle, etc. Introductory examples of the restrictions near the boundaries of finite numerical segments and of the probab...

  3. Foreign Equity Investment Restrictions, Capital Flight, and Shareholder Wealth Maximization

    OpenAIRE

    Stulz, René M.

    1995-01-01

    This paper provides a theory of foreign equity investment restrictions. We consider a model where the demand function for domestic shares differs between domestic and foreign investors because of dead-weight costs in holding domestic and foreign securities that depend on the country of residence of investors. We show that domestic entrepreneurs maximize firm value by discriminating between domestic and foreign investors. The model implies that countries benefiting from capital flight have bin...

  4. Intrasexual Competition and Eating Restriction in Heterosexual and Homosexual Individuals

    OpenAIRE

    Li, Norman P.; Smith, April R.; Griskevicius, Vladas; Cason, Margaret J.; Bryan, Angela

    2010-01-01

    Restrictive eating attitudes and behaviors have been hypothesized to be related to processes of intrasexual competition. According to this perspective, within-sex competition for status serves the adaptive purpose of attracting mates. As such, status competition salience may lead to concerns of mating desirability. For heterosexual women and gay men, such concerns revolve around appearing youthful and thus, thinner. Following this logic, we examined how exposure to high-status and competitive...

  5. Developing a programmed restriction endonuclease for highly specific DNA cleavage

    OpenAIRE

    Eisenschmidt, Kristin; Lanio, Thomas; Simoncsits, András; Jeltsch, Albert; Pingoud, Vera; Wende, Wolfgang; Pingoud, Alfred

    2005-01-01

    Specific cleavage of large DNA molecules at few sites, necessary for the analysis of genomic DNA or for targeting individual genes in complex genomes, requires endonucleases of extremely high specificity. Restriction endonucleases (REase) that recognize DNA sequences of 4–8 bp are not sufficiently specific for this purpose. In principle, the specificity of REases can be extended by fusion to sequence recognition modules, e.g. specific DNA-binding domains or triple-helix forming oligonucleotid...

  6. The Restriction .on Educational Quality in Rural Schools

    Institute of Scientific and Technical Information of China (English)

    艾丽娜

    2012-01-01

    In order to understand the educational quality in rural schools, I went deep into Huangjia Middle School( situated in Northern China) to make the research. In this article, I focus on the restrictions on educational qualitys, which is one of the main themes about rural education. The factors influencing quality in rural schools are analyzed in this article .It is concluded that educational quality depends on the relationship of teaching and learning and its supporting context.

  7. Caloric Restriction Enhances Fear Extinction Learning in Mice

    OpenAIRE

    Riddle, Megan C; McKenna, Morgan C.; Yoon, Yone J; Pattwell, Siobhan S.; Santos, Patricia Mae G; Casey, B. J.; Glatt, Charles E.

    2013-01-01

    Fear extinction learning, the ability to reassess a learned cue of danger as safe when it no longer predicts aversive events, is often dysregulated in anxiety disorders. Selective serotonin reuptake inhibitors (SSRI's) enhance neural plasticity and their ability to enhance fear extinction learning may explain their anxiolytic properties. Caloric restriction (CR) has SSRI-like effects on neural plasticity and anxiety-related behavior. We implemented CR in mice to determine its effects on condi...

  8. Metabolic and Neuropsychiatric Effects of Calorie Restriction and Sirtuins

    OpenAIRE

    Libert, Sergiy; Guarente, Lenny

    2014-01-01

    Most living organisms, including humans, age. Over time the ability to do physical and intellectual work deteriorates, and susceptibility to infectious, metabolic, and neurodegenerative diseases increases, which leads to general fitness decline and ultimately to death. Work in model organisms has demonstrated that genetic and environmental manipulations can prevent numerous age-associated diseases, improve health at advanced age, and increase life span. Calorie restriction (CR) (consumption o...

  9. Average Contrastive Divergence for Training Restricted Boltzmann Machines

    OpenAIRE

    Xuesi Ma; Xiaojie Wang

    2016-01-01

    This paper studies contrastive divergence (CD) learning algorithm and proposes a new algorithm for training restricted Boltzmann machines (RBMs). We derive that CD is a biased estimator of the log-likelihood gradient method and make an analysis of the bias. Meanwhile, we propose a new learning algorithm called average contrastive divergence (ACD) for training RBMs. It is an improved CD algorithm, and it is different from the traditional CD algorithm. Finally, we obtain some experimental resul...

  10. Calorie restriction and prevention of age-associated chronic disease

    OpenAIRE

    Omodei, Daniela; Fontana, Luigi

    2011-01-01

    Life expectancy in the world has increased dramatically during the last century; the number of older adults is expected to rise while the number of youths will decline in the near future. This demographic shift has considerable public health and economic implications since aging is associated with the development of serious chronic diseases. Calorie restriction (CR) is the most effective nutritional intervention for slowing aging and preventing chronic disease in rodents. In non-human and hum...

  11. Quantum Hall transitions: An exact theory based on conformal restriction

    OpenAIRE

    Bettelheim, E.; Gruzberg, I. A.; Ludwig, A. W. W.

    2012-01-01

    We revisit the problem of the plateau transition in the integer quantum Hall effect. Here we develop an analytical approach for this transition, based on the theory of conformal restriction. This is a mathematical theory that was recently developed within the context of the Schramm-Loewner evolution which describes the stochastic geometry of fractal curves and other stochastic geometrical fractal objects in 2D space. Observables elucidating the connection with the plateau transition include t...

  12. A Contribution to Berth Allocation Problem Solution with Draft Restrictions

    OpenAIRE

    Grubišić, Neven; Vilke, Siniša; Barić, Mate

    2015-01-01

    Models for berth assignments help to solve logistic problems in container terminals and are important decision making tools. This is particularly so where, because of the system complexity and vessels arrival rate, problems cannot be solved empirically. Another issue concerns potential infrastructure and equipment shortcomings, where high utilization of the existing system components is required. In this paper, the authors focus on draft or depth restrictions that may occur alongside a ...

  13. Troponin Ⅰ,cardiac diastolic dysfunction and restrictive cardiomyopathy

    Institute of Scientific and Technical Information of China (English)

    Xu-pei HUANG; Jian-feng DU

    2004-01-01

    Cardiomyopathies are diseases of heart muscle that are associated with cardiac dysfunction. Molecular genetic studies performed to date have demonstrated that the damage or mutations in several sarcomeric contractile protein genes are associated with the development of the diseases. In this review, cardiac troponin Ⅰ, one of the sarcomeric thin filament protein, will be discussed regarding its role in cardiac function, its deficiency-related diastolic dysfunction, and the mutation of this protein-mediated restrictive cardiomyopathy.

  14. Impacts of WTO restrictions on subsidized EU sugar exports

    OpenAIRE

    Poonyth, Daneswar; Westhoff, Patrick; Womack, Abner; Adams, Gary M.

    2000-01-01

    The study evaluates the impact of World Trade Organization (WTO) restrictions on the European Union (EU) sugar sector and the world sugar market. A small reduction in production quotas would be sufficient to satisfy the export subsidy limitations of the Uruguay Round agreement. Complete elimination of export subsidies by 2005 would require either a 10% reduction in production quotas or the combination of an 8% reduction in quotas and an 11% reduction in intervention prices. Higher world price...

  15. Social Welfare Functionals on Restricted Domains and in Economic Environments

    OpenAIRE

    Georges Bordes; Hammond, Peter J.; Michel Le Breton

    1997-01-01

    March 1997 Arrow's ``impossibility'' and similar classical theorems are usually proved for an unrestricted domain of preference profiles. Recent work extends Arrow's theorem to various restricted but ``saturating'' domains of privately oriented, continuous, (strictly) convex, and (strictly) monotone ``economic preferences'' for private and/or public goods. For strongly saturating domains of more general utility profiles, this paper provides similar extensions of Wilson's theorem and of the st...

  16. Restrictions on running IRC (Internet Relay Chat) at CERN

    CERN Multimedia

    2005-01-01

    Due to the large number of computer security incidents at CERN where intruders have used IRC (Internet Relay Chat) software to control computers, IRC connections will be blocked in the CERN firewall from 1st February 2005. Personal use of IRC software is not permitted at CERN. Further details of the restrictions on both personal and professional use of IRC are documented at http://cern.ch/security/IRC.

  17. A database for compliance with land disposal restrictions

    International Nuclear Information System (INIS)

    The new restrictions on land disposal introduce additional challenges to hazardous waste managers. Laboratory waste streams consisting of small volumes of diverse waste types will be particularly difficult to manage due to the large number of possible treatment standards that could be applied. To help remedy this management problem, a user-friendly database has been developed to provide the regulatory information required for each of the hazardous wastes present in the wastes stream of a large research laboratory. 3 figs., 1 tab

  18. Constraint-induced restriction and extension operators with applications

    Institute of Scientific and Technical Information of China (English)

    Bo CHEN; Xiao-wei LI; Gao-lian LIU

    2009-01-01

    The Stokes operator is a differential-integral operator induced by the Stokes equations. In this paper, we analyze the Stokes operator from the point of view of the Helmholtz minimum dissipation principle. We show that, through the Hodge orthogonal decomposition, a pair of bounded linear operators, a restriction operator and an extension operator, are induced from the divergence-free constraint. As a consequence, we use it to calculate the eigenvaiues of the Stokes operator.

  19. Book review: Sexuality in Muslim contexts: restrictions and resistance

    OpenAIRE

    Mason, Olivia

    2013-01-01

    "Sexuality in Muslim Contexts: Restrictions and Resistance." Anissa Helie and Homa Hoodfar (eds). Zed Books. October 2012. --- Using case studies from Pakistan, Iran, Indonesia, China, Bangladesh, Israel and India, Sexuality in Muslim Contexts argues that Muslim religious traditions do not necessarily lead to conservative agendas but can promote emancipatory standpoints. Olivia Mason thinks however you currently understand sexuality in Muslim contexts this book will definitely change it fo...

  20. Learning restricted Boolean network model by time-series data.

    Science.gov (United States)

    Ouyang, Hongjia; Fang, Jie; Shen, Liangzhong; Dougherty, Edward R; Liu, Wenbin

    2014-01-01

    Restricted Boolean networks are simplified Boolean networks that are required for either negative or positive regulations between genes. Higa et al. (BMC Proc 5:S5, 2011) proposed a three-rule algorithm to infer a restricted Boolean network from time-series data. However, the algorithm suffers from a major drawback, namely, it is very sensitive to noise. In this paper, we systematically analyze the regulatory relationships between genes based on the state switch of the target gene and propose an algorithm with which restricted Boolean networks may be inferred from time-series data. We compare the proposed algorithm with the three-rule algorithm and the best-fit algorithm based on both synthetic networks and a well-studied budding yeast cell cycle network. The performance of the algorithms is evaluated by three distance metrics: the normalized-edge Hamming distance [Formula: see text], the normalized Hamming distance of state transition [Formula: see text], and the steady-state distribution distance μ (ssd). Results show that the proposed algorithm outperforms the others according to both [Formula: see text] and [Formula: see text], whereas its performance according to μ (ssd) is intermediate between best-fit and the three-rule algorithms. Thus, our new algorithm is more appropriate for inferring interactions between genes from time-series data.

  1. Cytosine methylation dysregulation in neonates following intrauterine growth restriction.

    Directory of Open Access Journals (Sweden)

    Francine Einstein

    Full Text Available BACKGROUND: Perturbations of the intrauterine environment can affect fetal development during critical periods of plasticity, and can increase susceptibility to a number of age-related diseases (e.g., type 2 diabetes mellitus; T2DM, manifesting as late as decades later. We hypothesized that this biological memory is mediated by permanent alterations of the epigenome in stem cell populations, and focused our studies specifically on DNA methylation in CD34+ hematopoietic stem and progenitor cells from cord blood from neonates with intrauterine growth restriction (IUGR and control subjects. METHODS AND FINDINGS: Our epigenomic assays utilized a two-stage design involving genome-wide discovery followed by quantitative, single-locus validation. We found that changes in cytosine methylation occur in response to IUGR of moderate degree and involving a restricted number of loci. We also identify specific loci that are targeted for dysregulation of DNA methylation, in particular the hepatocyte nuclear factor 4alpha (HNF4A gene, a well-known diabetes candidate gene not previously associated with growth restriction in utero, and other loci encoding HNF4A-interacting proteins. CONCLUSIONS: Our results give insights into the potential contribution of epigenomic dysregulation in mediating the long-term consequences of IUGR, and demonstrate the value of this approach to studies of the fetal origin of adult disease.

  2. Hanford land disposal restrictions plan for mixed wastes

    International Nuclear Information System (INIS)

    Since the early 1940s, the Hanford Site has been involved in the production and purification of nuclear defense materials. These production activities have resulted in the generation of large quantities of liquid and solid radioactive mixed waste. This waste is subject to regulation under authority of both the Resource Conservation and Recovery Act of 1976 (RCRA) and the Atomic Energy Act. The State of Washington Department of Ecology (Ecology), the US Environmental Protection Agency (EPA), and the US Department of Energy (DOE) have entered into an agreement, the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement) to bring Hanford Site Operations into compliance with dangerous waste regulations. The Tri-Party Agreement was amended to require development of the Hanford Land Disposal Restrictions Plan for Mixed Wastes (this plan) to comply with land disposal restrictions requirements for radioactive mixed waste. The Tri-Party Agreement requires, and the this plan provides, the following sections: Waste Characterization Plan, Storage Report, Treatment Report, Treatment Plan, Waste Minimization Plan, a schedule, depicting the events necessary to achieve full compliance with land disposal restriction requirements, and a process for establishing interim milestones. 34 refs., 28 figs., 35 tabs

  3. Fasting and Caloric Restriction in Cancer Prevention and Treatment.

    Science.gov (United States)

    Brandhorst, Sebastian; Longo, Valter D

    2016-01-01

    Cancer is the second leading cause of death in the USA and among the leading major diseases in the world. It is anticipated to continue to increase because of the growth of the aging population and prevalence of risk factors such as obesity, smoking, and/or poor dietary habits. Cancer treatment has remained relatively similar during the past 30 years with chemotherapy and/or radiotherapy in combination with surgery remaining the standard therapies although novel therapies are slowly replacing or complementing the standard ones. According to the American Cancer Society, the dietary recommendation for cancer patients receiving chemotherapy is to increase calorie and protein intake. In addition, there are no clear guidelines on the type of nutrition that could have a major impact on cancer incidence. Yet, various forms of reduced caloric intake such as calorie restriction (CR) or fasting demonstrate a wide range of beneficial effects able to help prevent malignancies and increase the efficacy of cancer therapies. Whereas chronic CR provides both beneficial and detrimental effects as well as major compliance challenges, periodic fasting (PF), fasting-mimicking diets (FMDs), and dietary restriction (DR) without a reduction in calories are emerging as interventions with the potential to be widely used to prevent and treat cancer. Here, we review preclinical and preliminary clinical studies on dietary restriction and fasting and their role in inducing cellular protection and chemotherapy resistance.

  4. Restricted numerical shadow and geometry of quantum entanglement

    CERN Document Server

    Puchała, Zbigniew; Gawron, Piotr; Dunkl, Charles F; Holbrook, John A; Życzkowski, Karol

    2012-01-01

    The restricted numerical range W_R(A) of an operator A acting on a D-dimensional Hilbert space is defined as a set of all possible expectation values of this operator among pure states which belong to a certain subset R of the of set of pure quantum states of dimension D. One considers for instance the set of real states, or in the case of composite spaces, the set of product states and the set of maximally entangled states. Combining the operator theory with a probabilistic approach we introduce the restricted numerical shadow of A -- a normalized probability distribution on the complex plane supported in W_R(A). Its value at point z in C is equal to the probability that the expectation value is equal to z, where |\\psi> represents a random quantum state in subset R distributed according to the natural measure on this set, induced by the unitarily invariant Fubini--Study measure. Studying restricted shadows of operators of a fixed size D=N_A N_B we analyse the geometry of sets of separable and maximally enta...

  5. Comprehensive tobacco marketing restrictions: promotion, packaging, price and place.

    Science.gov (United States)

    Henriksen, Lisa

    2012-03-01

    Evidence of the causal role of marketing in the tobacco epidemic and the advent of the WHO Framework Convention on Tobacco Control have inspired more than half the countries in the world to ban some forms of tobacco marketing. This paper briefly describes the ways in which cigarette marketing is restricted and the tobacco industry's efforts to subvert restrictions. It reviews what is known about the impact of marketing regulations on smoking by adults and adolescents. It also addresses what little is known about the impact of marketing bans in relation to concurrent population-level interventions, such as price controls, anti-tobacco media campaigns and smoke-free laws. Point of sale is the least regulated channel and research is needed to address the immediate and long-term consequences of policies to ban retail advertising and pack displays. Comprehensive marketing restrictions require a global ban on all forms of promotion, elimination of packaging and price as marketing tools, and limitations on the quantity, type and location of tobacco retailers.

  6. Fasting and Caloric Restriction in Cancer Prevention and Treatment.

    Science.gov (United States)

    Brandhorst, Sebastian; Longo, Valter D

    2016-01-01

    Cancer is the second leading cause of death in the USA and among the leading major diseases in the world. It is anticipated to continue to increase because of the growth of the aging population and prevalence of risk factors such as obesity, smoking, and/or poor dietary habits. Cancer treatment has remained relatively similar during the past 30 years with chemotherapy and/or radiotherapy in combination with surgery remaining the standard therapies although novel therapies are slowly replacing or complementing the standard ones. According to the American Cancer Society, the dietary recommendation for cancer patients receiving chemotherapy is to increase calorie and protein intake. In addition, there are no clear guidelines on the type of nutrition that could have a major impact on cancer incidence. Yet, various forms of reduced caloric intake such as calorie restriction (CR) or fasting demonstrate a wide range of beneficial effects able to help prevent malignancies and increase the efficacy of cancer therapies. Whereas chronic CR provides both beneficial and detrimental effects as well as major compliance challenges, periodic fasting (PF), fasting-mimicking diets (FMDs), and dietary restriction (DR) without a reduction in calories are emerging as interventions with the potential to be widely used to prevent and treat cancer. Here, we review preclinical and preliminary clinical studies on dietary restriction and fasting and their role in inducing cellular protection and chemotherapy resistance. PMID:27557543

  7. A randomized trial of dietary sodium restriction in CKD.

    Science.gov (United States)

    McMahon, Emma J; Bauer, Judith D; Hawley, Carmel M; Isbel, Nicole M; Stowasser, Michael; Johnson, David W; Campbell, Katrina L

    2013-12-01

    There is a paucity of quality evidence regarding the effects of sodium restriction in patients with CKD, particularly in patients with pre-end stage CKD, where controlling modifiable risk factors may be especially important for delaying CKD progression and cardiovascular events. We conducted a double-blind placebo-controlled randomized crossover trial assessing the effects of high versus low sodium intake on ambulatory BP, 24-hour protein and albumin excretion, fluid status (body composition monitor), renin and aldosterone levels, and arterial stiffness (pulse wave velocity and augmentation index) in 20 adult patients with hypertensive stage 3-4 CKD as phase 1 of the LowSALT CKD study. Overall, salt restriction resulted in statistically significant and clinically important reductions in BP (mean reduction of systolic/diastolic BP, 10/4 mm Hg; 95% confidence interval, 5 to 15 /1 to 6 mm Hg), extracellular fluid volume, albuminuria, and proteinuria in patients with moderate-to-severe CKD. The magnitude of change was more pronounced than the magnitude reported in patients without CKD, suggesting that patients with CKD are particularly salt sensitive. Although studies with longer intervention times and larger sample sizes are needed to confirm these benefits, this study indicates that sodium restriction should be emphasized in the management of patients with CKD as a means to reduce cardiovascular risk and risk for CKD progression.

  8. Restricted common data in anonymous E-cash system

    Institute of Scientific and Technical Information of China (English)

    ZHANG Xiang-jun; CHEN Ke-fei

    2006-01-01

    Discuss the problem of infinite increasing coin list in anonymous E-cash systems, which reduce the efficiency of whole system greatly. Though some methods are suggested, no one can solve the problem with high efficiency and flexibility. Here, we use the technique of adding information in blind signatures to deal with this problem. Through adding timestamp in signatures, we can separate the valid period of all used coins into pieces. Only the coins in the last stage are recorded. So the scale of the coins list is controlled. We also analyze the anonymity of these data, and add some indispensable restrictions to them. These restrictions can ensure that the imported data don't break the anonymity of the customers. In order to fulfill these qualifications, we lead to the concept of restricted common data (RCD). Furthermore, we propose two schemes to add RCD in the blind signature. The simple one is easy to implement, while the complex one can note the value of the coin. The usage of RCD leads to little additional cost, as well as maintaining the anonymity of customers. This method fits for most kinds of anonymous E-cash systems.

  9. Quantum Hall transitions: An exact theory based on conformal restriction

    Science.gov (United States)

    Bettelheim, E.; Gruzberg, I. A.; Ludwig, A. W. W.

    2012-10-01

    We revisit the problem of the plateau transition in the integer quantum Hall effect. Here we develop an analytical approach for this transition, and for other two-dimensional disordered systems, based on the theory of “conformal restriction.” This is a mathematical theory that was recently developed within the context of the Schramm-Loewner evolution which describes the “stochastic geometry” of fractal curves and other stochastic geometrical fractal objects in two-dimensional space. Observables elucidating the connection with the plateau transition include the so-called point-contact conductances (PCCs) between points on the boundary of the sample, described within the language of the Chalker-Coddington network model for the transition. We show that the disorder-averaged PCCs are characterized by a classical probability distribution for certain geometric objects in the plane (which we call pictures), occurring with positive statistical weights, that satisfy the crucial so-called restriction property with respect to changes in the shape of the sample with absorbing boundaries; physically, these are boundaries connected to ideal leads. At the transition point, these geometrical objects (pictures) become fractals. Upon combining this restriction property with the expected conformal invariance at the transition point, we employ the mathematical theory of “conformal restriction measures” to relate the disorder-averaged PCCs to correlation functions of (Virasoro) primary operators in a conformal field theory (of central charge c=0). We show how this can be used to calculate these functions in a number of geometries with various boundary conditions. Since our results employ only the conformal restriction property, they are equally applicable to a number of other critical disordered electronic systems in two spatial dimensions, including for example the spin quantum Hall effect, the thermal metal phase in symmetry class D, and classical diffusion in two

  10. Calorie restriction increases muscle mitochondrial biogenesis in healthy humans.

    Directory of Open Access Journals (Sweden)

    Anthony E Civitarese

    2007-03-01

    Full Text Available BACKGROUND: Caloric restriction without malnutrition extends life span in a range of organisms including insects and mammals and lowers free radical production by the mitochondria. However, the mechanism responsible for this adaptation are poorly understood. METHODS AND FINDINGS: The current study was undertaken to examine muscle mitochondrial bioenergetics in response to caloric restriction alone or in combination with exercise in 36 young (36.8 +/- 1.0 y, overweight (body mass index, 27.8 +/- 0.7 kg/m(2 individuals randomized into one of three groups for a 6-mo intervention: Control, 100% of energy requirements; CR, 25% caloric restriction; and CREX, caloric restriction with exercise (CREX, 12.5% CR + 12.5% increased energy expenditure (EE. In the controls, 24-h EE was unchanged, but in CR and CREX it was significantly reduced from baseline even after adjustment for the loss of metabolic mass (CR, -135 +/- 42 kcal/d, p = 0.002 and CREX, -117 +/- 52 kcal/d, p = 0.008. Participants in the CR and CREX groups had increased expression of genes encoding proteins involved in mitochondrial function such as PPARGC1A, TFAM, eNOS, SIRT1, and PARL (all, p < 0.05. In parallel, mitochondrial DNA content increased by 35% +/- 5% in the CR group (p = 0.005 and 21% +/- 4% in the CREX group (p < 0.004, with no change in the control group (2% +/- 2%. However, the activity of key mitochondrial enzymes of the TCA (tricarboxylic acid cycle (citrate synthase, beta-oxidation (beta-hydroxyacyl-CoA dehydrogenase, and electron transport chain (cytochrome C oxidase II was unchanged. DNA damage was reduced from baseline in the CR (-0.56 +/- 0.11 arbitrary units, p = 0.003 and CREX (-0.45 +/- 0.12 arbitrary units, p = 0.011, but not in the controls. In primary cultures of human myotubes, a nitric oxide donor (mimicking eNOS signaling induced mitochondrial biogenesis but failed to induce SIRT1 protein expression, suggesting that additional factors may regulate SIRT1 content

  11. Simple and rapid human papillomavirus genotyping method by restriction fragment length polymorphism analysis with two restriction enzymes.

    Science.gov (United States)

    Chen, Linghan; Watanabe, Ken; Haruyama, Takahiro; Kobayashi, Nobuyuki

    2013-07-01

    Cervical cancer, the third most common cancer that affects women worldwide, is caused by the human papillomavirus (HPV) and is treatable when detected at an early stage. To date, more than 100 different HPV types have been described, and the development of simple, low-cost, and accurate methods to distinguish HPV genotypes is highly warranted. In this study, an HPV genotyping assay based on polymerase chain reaction (PCR) was evaluated. This method involved the use of MY09/11 primers followed by restriction fragment length polymorphism (RFLP) analysis with the restriction enzymes HpyCH4V and NlaIII. Cervical specimens preserved using CytoRich Blue fluid were collected from 1,134 female volunteers for HPV detection, and 1,111 valid samples were amplified using PCR. The PCR method was sensitive enough to detect 25 copies of HPV18, and three copies of HPV16. Out of 202 PCR-positive samples, HPV genotypes were determined in 189 samples (93.6%) by this RFLP method. Results were then evaluated further by capillary sequencing method. Concordant results between the two tests were as high as 96.0%. Thirteen samples, which tested negative with RFLP, were verified as non-specific amplifications with PCR. In conclusion, this PCR-RFLP method using restriction enzymes HpyCH4V and NlaIII is simple, non-labor intensive, and is applicable for the inexpensive determination of HPV genotypes in clinical samples.

  12. Carbohydrate restriction improves the features of Metabolic Syndrome. Metabolic Syndrome may be defined by the response to carbohydrate restriction

    Directory of Open Access Journals (Sweden)

    Feinman Richard D

    2005-11-01

    Full Text Available Abstract Metabolic Syndrome (MetS represents a constellation of markers that indicates a predisposition to diabetes, cardiovascular disease and other pathologic states. The definition and treatment are a matter of current debate and there is not general agreement on a precise definition or, to some extent, whether the designation provides more information than the individual components. We consider here five indicators that are central to most definitions and we provide evidence from the literature that these are precisely the symptoms that respond to reduction in dietary carbohydrate (CHO. Carbohydrate restriction is one of several strategies for reducing body mass but even in the absence of weight loss or in comparison with low fat alternatives, CHO restriction is effective at ameliorating high fasting glucose and insulin, high plasma triglycerides (TAG, low HDL and high blood pressure. In addition, low fat, high CHO diets have long been known to raise TAG, lower HDL and, in the absence of weight loss, may worsen glycemic control. Thus, whereas there are numerous strategies for weight loss, a patient with high BMI and high TAG is likely to benefit most from a regimen that reduces CHO intake. Reviewing the literature, benefits of CHO restriction are seen in normal or overweight individuals, in normal patients who meet the criteria for MetS or in patients with frank diabetes. Moreover, in low fat studies that ameliorate LDL and total cholesterol, controls may do better on the symptoms of MetS. On this basis, we feel that MetS is a meaningful, useful phenomenon and may, in fact, be operationally defined as the set of markers that responds to CHO restriction. Insofar as this is an accurate characterization it is likely the result of the effect of dietary CHO on insulin metabolism. Glucose is the major insulin secretagogue and insulin resistance has been tied to the hyperinsulinemic state or the effect of such a state on lipid metabolism. The

  13. Metabolomics of dietary fatty acid restriction in patients with phenylketonuria.

    Directory of Open Access Journals (Sweden)

    Ulrike Mütze

    Full Text Available BACKGROUND: Patients with phenylketonuria (PKU have to follow a lifelong phenylalanine restricted diet. This type of diet markedly reduces the intake of saturated and unsaturated fatty acids especially long chain polyunsaturated fatty acids (LC-PUFA. Long-chain saturated fatty acids are substrates of mitochondrial fatty acid oxidation for acetyl-CoA production. LC-PUFA are discussed to affect inflammatory and haemostaseological processes in health and disease. The influence of the long term PKU diet on fatty acid metabolism with a special focus on platelet eicosanoid metabolism has been investigated in the study presented here. METHODOLOGY/PRINCIPAL FINDINGS: 12 children with PKU under good metabolic control and 8 healthy controls were included. Activated fatty acids (acylcarnitines C6-C18 in dried blood and the cholesterol metabolism in serum were analyzed by liquid chromatographic tandem mass spectrometry (LC-MS/MS. Fatty acid composition of plasma glycerophospholipids was determined by gas chromatography. LC-PUFA metabolites were analyzed in supernatants by LC-MS/MS before and after platelet activation and aggregation using a standardized protocol. Patients with PKU had significantly lower free carnitine and lower activated fatty acids in dried blood compared to controls. Phytosterols as marker of cholesterol (re- absorption were not influenced by the dietary fatty acid restriction. Fatty acid composition in glycerophospholipids was comparable to that of healthy controls. However, patients with PKU showed significantly increased concentrations of y-linolenic acid (C18:3n-6 a precursor of arachidonic acid. In the PKU patients significantly higher platelet counts were observed. After activation with collagen platelet aggregation and thromboxane B(2 and thromboxane B(3 release did not differ from that of healthy controls. CONCLUSION/SIGNIFICANCE: Long-term dietary fatty acid restriction influenced the intermediates of mitochondrial beta

  14. Hypertension: Salt restriction, sodium homeostasis, and other ions

    Directory of Open Access Journals (Sweden)

    Neeru Gupta

    2011-01-01

    Full Text Available Salt is composed of Sodium Chloride (NaCl which in body water becomes essential electrolytes, viz., Sodium (Na >+ and Chloride (Cl >- ions, including in the blood and other extracellular fluids (ECF. Na >+ ions are necessary cations in muscle contractions and their depletion will effect all the muscles in body including smooth muscle contraction of blood vessels, a fact which is utilized in lowering the blood pressure. Na+ ions also hold water with them in the ECF. Na >+ homeostasis in body is maintained by thirst (water intake, kidneys (urinary excretion and skin (sweating. In Na >+ withdrawal, body tries to maintain homeostasis as far as possible. However, in certain conditions (e.g., during exercise, intake of drugs and in disorders causing Syndrome of Inappropriate Anti Diuretic Hormone Secretion (SIADH, diuretics, diarrhea coupled with moderate or severe dietary salt restriction (anorexia nervosa, hyponatremia can get precipitated. Hyponatremia is one end point in the spectrum of disorders caused by severe Na >+ depletion whereas in moderate depletion it can cause hypohydration (or less total body water and lower urinary volume (U v . Moreover, salt sensitivity varies in various populations leading to different responses in relation to dietary Na >+ intake. Diabetes and Hypertension often co-exist but Na >+ withdrawal in salt sensitive subjects worsens diabetes though hypertension gets better and reverse occurs in salt loading. Therefore, Na >+ or salt restriction may be non-physiological. In hypertensive subjects other alternatives to Na >+ withdrawal could be Potassium (K >+ and Calcium (Ca >2+ supplementation. Further studies are required to monitor safety/side effects of salt restriction.

  15. Hypertension: salt restriction, sodium homeostasis, and other ions.

    Science.gov (United States)

    Gupta, Neeru; Jani, Kishan Kumar; Gupta, Nivedita

    2011-03-01

    Salt is composed of Sodium Chloride (NaCl) which in body water becomes essential electrolytes, viz., Sodium (Na⁺) and Chloride (Cl⁻) ions, including in the blood and other extracellular fluids (ECF). Na⁺ ions are necessary cations in muscle contractions and their depletion will effect all the muscles in body including smooth muscle contraction of blood vessels, a fact which is utilized in lowering the blood pressure. Na⁺ ions also hold water with them in the ECF. Na⁺ homeostasis in body is maintained by thirst (water intake), kidneys (urinary excretion) and skin (sweating). In Na⁺ withdrawal, body tries to maintain homeostasis as far as possible. However, in certain conditions (e.g., during exercise, intake of drugs and in disorders causing Syndrome of Inappropriate Anti Diuretic Hormone Secretion (SIADH), diuretics, diarrhea) coupled with moderate or severe dietary salt restriction (anorexia nervosa), hyponatremia can get precipitated. Hyponatremia is one end point in the spectrum of disorders caused by severe Na⁺ depletion whereas in moderate depletion it can cause hypohydration (or less total body water) and lower urinary volume (U v ). Moreover, salt sensitivity varies in various populations leading to different responses in relation to dietary Na⁺ intake. Diabetes and Hypertension often co-exist but Na⁺ withdrawal in salt sensitive subjects worsens diabetes though hypertension gets better and reverse occurs in salt loading. Therefore, Na⁺ or salt restriction may be non-physiological. In hypertensive subjects other alternatives to Na⁺ withdrawal could be Potassium (K⁺) and Calcium (Ca⁺²) supplementation. Further studies are required to monitor safety/side effects of salt restriction. PMID:23250294

  16. Perspective food addiction, caloric restriction, and dopaminergic neurotransmission

    DEFF Research Database (Denmark)

    Stankowska, Arwen Urrsula Malgorzata; Gjedde, Albert

    2013-01-01

    for a reduced cognitive reward condition. The combination of caloric restriction and food addiction imparts a high risk of relapse as a result of further reduction of dopaminergic neurotransmission and the subsequent loss of reward. As with drugs of abuse, ingestion of large quantities of sugar in circumstances......, and reduced activity in prefrontal regions of the cerebral cortex. The neurobiological characteristics suggest that obese people also have a pathological dependence in common with addicts, in the form of food addiction. Malnutrition and dieting both relate to binge eating, possibly as a compensation...

  17. Helping Computers Understand Geographically-Bound Activity Restrictions

    OpenAIRE

    Soll, Marcus; Naumann, Philipp; Schöning, Johannes; SAMSONOV, Pavel; Hecht, Brent

    2016-01-01

    The lack of certain types of geographic data prevents the development of location-aware technologies in a number of important domains. One such type of “unmapped” geographic data is space usage rules (SURs), which are defined as geographically-bound activity restrictions (e.g. “no dogs”, “no smoking”, “no fishing”, “no skateboarding”). Researchers in the area of humancomputer interaction have recently begun to develop techniques for the automated mapping of SURs with the aim of suppo...

  18. Visual expression of the experiences of restrictive eating

    DEFF Research Database (Denmark)

    Mark, Edith

    Background of the research: Visual methods are used in nursing research. These methods include media such as film, video, still images, material artifacts and drawing. The current study is a PhD project, dealing with children's experiences of eating restrictively (diabetes or obesity). Visual...... and as an option in the dialogue with the patient. Material and method description: Drawing, modeling and role-playing with stuffed animals is part of the material from the study and illustrate how visual methods can be used in relationship with the child. Result: The play and creativity have a function...

  19. Driving Restrictions That Work? Quito's Pico y Placa Program

    OpenAIRE

    Paul E. Carrillo; Arun S. Malik; Jiseon Yoo

    2013-01-01

    Programs to reduce tra¢ c congestion and air pollution by restricting use of motor vehicles on working days have generally not met with success given existing studies of such programs in a number of cities. We conduct the Örst study of Quito, Ecuadorís three-year-old Pico y Placa program and Önd that it has reduced ambient concentrations of carbon monoxide (CO), a pollutant primarily emitted by vehicles, by 9-11% during peak tra¢ c hours. During an extended daytime period that encompasses hou...

  20. Stepsize Restrictions for Boundedness and Monotonicity of Multistep Methods

    KAUST Repository

    Hundsdorfer, W.

    2011-04-29

    In this paper nonlinear monotonicity and boundedness properties are analyzed for linear multistep methods. We focus on methods which satisfy a weaker boundedness condition than strict monotonicity for arbitrary starting values. In this way, many linear multistep methods of practical interest are included in the theory. Moreover, it will be shown that for such methods monotonicity can still be valid with suitable Runge-Kutta starting procedures. Restrictions on the stepsizes are derived that are not only sufficient but also necessary for these boundedness and monotonicity properties. © 2011 Springer Science+Business Media, LLC.

  1. Detecting Violations of Unidimensionality by Order-Restricted Inference Methods

    Directory of Open Access Journals (Sweden)

    Moritz eHeene

    2016-03-01

    Full Text Available The assumption of unidimensionality and quantitative measurement represents one of the key concepts underlying most of the commonly applied of item response models. The assumption of unidimensionality is frequently tested although most commonly applied methods have been shown having low power against violations of unidimensionality whereas the assumption of quantitative measurement remains in most of the cases only an (implicit assumption. On the basis of a simulation study it is shown that order restricted inference methods within a Markov Chain Monte Carlo framework can successfully be used to test both assumptions.

  2. Stability analysis of restricted non-static axial symmetry

    Energy Technology Data Exchange (ETDEWEB)

    Sharif, M.; Bhatti, M. Zaeem Ul Haq, E-mail: msharif.math@pu.edu.pk, E-mail: mzaeem.math@gmail.com [Department of Mathematics, University of the Punjab, Quaid-e-Azam Campus, Lahore-54590 (Pakistan)

    2013-11-01

    This paper aims to investigate the instability of very restricted class of non-static axially symmetric spacetime with anisotropic matter configuration. The perturbation scheme is established for the Einstein field equations and conservation laws. The instability range in the Newtonian and post-Newtonian regions are explored by constructing the collapse equation in this scenario. It is found that the adiabatic index plays an important role in the stability analysis which depends upon the physical parameters i.e., energy density and anisotropic pressure of the fluid distribution.

  3. Traffic restrictions due to wind on the Fehmarn Belt bridge

    DEFF Research Database (Denmark)

    Dellwik, E.; Mann, Jakob; Rosenhagen, G.

    2006-01-01

    This report documents the calculations carried out in order to estimate the wind climate at the site where the Fehmarn Belt bridge is planned. Further, an estimate of how often and for how long traffic restrictions will be enforced according to statedcriteria (sec. 3.2) is given. This estimate...... are the same as used in this report and here the comparison is satisfactory. We estimate that the prospective Fehmarn Belt bridge will be closed roughly 2% of the timefor light roadway vehicles (unloaded trucks and caravans), corresponding to 7 days per year. This is slightly less than for the Fehmarnsund...

  4. Principal Bundles whose Restrictions to a Curve are Isomorphic

    Indian Academy of Sciences (India)

    Sudarshan Rajendra Gurjar

    2011-05-01

    Let be a normal projective variety defined over an algebraically closed field . Let $|O_X(1)|$ be a very ample invertible sheaf on . Let be an affine algebraic group defined over . Let $E_G$ and $F_G$ be two principal -bundles on . Then there exists an integer $n \\gg 0$ (depending on $E_G$ and $F_G$) such that if the restrictions of $E_G$ and $F_G$ to a curve $C\\in |O_X(n)|$ are isomorphic, then they are isomorphic on all of .

  5. DNA restriction-modification systems mediate plasmid maintenance.

    OpenAIRE

    Kulakauskas, S; Lubys, A; Ehrlich, S. D.

    1995-01-01

    Two plasmid-carried restriction-modification (R-M) systems, EcoRI (from pMB1 of Escherichia coli) and Bsp6I (from pXH13 of Bacillus sp. strain RFL6), enhance plasmid segregational stability in E. coli and Bacillus subtilis, respectively. Inactivation of the endonuclease or the presence of the methylase in trans abolish the stabilizing activity of the R-M systems. We propose that R-M systems mediate plasmid segregational stability by postsegregational killing of plasmid-free cells. Plasmid-enc...

  6. DUNDRUM Restriction-Intrusion of Liberty Ladders (DRILL) Audit Toolkit

    LENUS (Irish Health Repository)

    Kennedy, Harry G

    2011-09-01

    This series of rating \\'ladders\\' is intended to allow a quantitative and qualitative analysis of the use of restrictive and intrusive interventions as part of the therapeutic management of violence and aggression in psychiatric hospital settings. This is an evolving handbook. The ladders are currently organised to facilitate a behavioural analysis. Context, antecedents, behaviour, interventions, consequences are conceptualised as a series of events organised in temporal sequence so that causes, interactions and effects can be considered. The complexity of analysis possible is limited by the statistical power of the numbers of cases and events available. \\r\

  7. Stability analysis of restricted non-static axial symmetry

    International Nuclear Information System (INIS)

    This paper aims to investigate the instability of very restricted class of non-static axially symmetric spacetime with anisotropic matter configuration. The perturbation scheme is established for the Einstein field equations and conservation laws. The instability range in the Newtonian and post-Newtonian regions are explored by constructing the collapse equation in this scenario. It is found that the adiabatic index plays an important role in the stability analysis which depends upon the physical parameters i.e., energy density and anisotropic pressure of the fluid distribution

  8. Russell body duodenitis with immunoglobulin kappa light chain restriction.

    Science.gov (United States)

    Munday, William R; Kapur, Lucy Harn; Xu, Mina; Zhang, Xuchen

    2015-01-16

    Russell bodies are eosinophilic intracytoplasmic globules which are likely the result of disturbed secretion of immunoglobulins that accumulate within the plasma cell. Russell body collections have been identified within the stomach, known as Russell body gastritis. Similar lesions within the duodenum are referred to as Russell body duodenitis, which is rare. Several Russell body gastritis case reports are associated with Helicobacter pylori. However, the etiology of Russell body duodenitis remains unclear. Here we report the first case of Russell body duodenitis with immunoglobulin light chain restriction in a background of peptic duodenitis. PMID:25610537

  9. Fixed Points of the Restricted Delaunay Triangulation Operator

    OpenAIRE

    Khoury, Marc; Shewchuk, Jonathan Richard

    2016-01-01

    The restricted Delaunay triangulation can be conceived as an operator that takes as input a k-manifold (typically smooth) embedded in R^d and a set of points sampled with sufficient density on that manifold, and produces as output a k-dimensional triangulation of the manifold, the input points serving as its vertices. What happens if we feed that triangulation back into the operator, replacing the original manifold, while retaining the same set of input points? If k = 2 and the sample point...

  10. 48 CFR 225.7003 - Restrictions on acquisition of specialty metals.

    Science.gov (United States)

    2010-10-01

    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Restrictions on acquisition of specialty metals. 225.7003 Section 225.7003 Federal Acquisition Regulations System DEFENSE... Restrictions on acquisition of specialty metals....

  11. Trade restrictions as viable means of enforcing compliance with international environmental law: an economic assessment

    Energy Technology Data Exchange (ETDEWEB)

    Kirchgaessner, G. [SIASR-HSG, St. Gallen (Switzerland); Mohr, E. [IWOe-HSG, St. Gallen (Switzerland)

    1996-12-31

    The contribution addresses some general problems of trade restrictions and the established international or national regimes of restrictions and sanctions, the role of environmental treaties and agreements, and issues of the debt-environmental treaty link-up.(CB)

  12. Regression Analysis of Restricted Mean Survival Time Based on Pseudo-Observations

    DEFF Research Database (Denmark)

    Andersen, Per Kragh; Hansen, Mette Gerster; Klein, John P.

    2004-01-01

    censoring; hazard function; health economics; mean survival time; pseudo-observations; regression model; restricted mean survival time; survival analysis......censoring; hazard function; health economics; mean survival time; pseudo-observations; regression model; restricted mean survival time; survival analysis...

  13. Regression analysis of restricted mean survival time based on pseudo-observations

    DEFF Research Database (Denmark)

    Andersen, Per Kragh; Hansen, Mette Gerster; Klein, John P.

    censoring; hazard function; health economics; regression model; survival analysis; mean survival time; restricted mean survival time; pseudo-observations......censoring; hazard function; health economics; regression model; survival analysis; mean survival time; restricted mean survival time; pseudo-observations...

  14. Photoperiod interacts with food restriction on performance in the Barnes maze in female California mice

    OpenAIRE

    Steinman, Michael Q.; Crean, Katie K.; Trainor, Brian C.

    2010-01-01

    Food restriction has been reported to have positive effects on cognition. This study examines how another environmental factor, daylength, can alter the impact of food restriction on the brain and behavior. Female California mice (Peromyscus californicus), housed on either long days (16L:8D) or short days (8L:16D) were restricted to 80% of their normal baseline food intake or provided food ad libitum. Testing in a Barnes maze revealed that the effects of food restriction depend on photoperiod...

  15. The Effects of Driving Restrictions on Air Quality and Driver Behavior

    OpenAIRE

    Carnovale, Maria; GIBSON, Matthew

    2013-01-01

    We evaluate whether driving restrictions improve air quality.  While Milan's restriction decreases overall air pollution, there is a significant behavioral response that attenuates the effect.  Our study expoits the natural experiment created by an unanticipated court injunction suspending Milan's restriction.  Drivers respond to the restriction with: 1) intertemporal substituion toward the unpriced period; 2) substitution toward exempt vehicles; and 3) spatial substitution toward unpriced ro...

  16. An Efficient Restrictive Blind Signature Scheme with Applications to Electronic Cash

    Institute of Scientific and Technical Information of China (English)

    2002-01-01

    In this paper, a new restrictive blind signature scheme is proposed. Compared with Brands restrictive blind signature scheme, our scheme is even more restrictive and efficient. And our scheme is proved secure, too. A new withdrawal protocol of electronic cash system is designed by using our restrictive blind signature scheme, which is more efficient than the withdrawal protocol and is more appropriate for adopting pre-processing and post-processing.

  17. Therapeutic potential of ghrelin in restricting-type anorexia nervosa.

    Science.gov (United States)

    Hotta, Mari; Ohwada, Rina; Akamizu, Takashi; Shibasaki, Tamotsu; Kangawa, Kenji

    2012-01-01

    Anorexia nervosa (AN) is an eating disorder characterized by a decrease in caloric intake and malnutrition. It is associated with a variety of medical morbidities as well as significant mortality. Nutritional support is of paramount importance to prevent impaired quality of life later in life in affected patients. Some patients with restricting-type AN who are fully motivated to gain body weight cannot increase their food intake because of malnutrition-induced gastrointestinal dysfunction. Chronicity of AN prevents participation in social activities and leads to increased medical expenses. Therefore, there is a pressing need for effective appetite-stimulating therapies for patients with AN. Ghrelin is the only orexigenic hormone that can be given intravenously. Intravenous infusion of ghrelin is reported to increase food intake and body weight in healthy subjects as well as in patients with poor nutritional status. Here, we introduce the results of a pilot study that investigated the effects of ghrelin on appetite, energy intake, and nutritional parameters in five patients with restricting-type AN, who are fully motivated to gain body weight but could not increase their food intake because of malnutrition-induced gastrointestinal dysfunction. PMID:22975066

  18. REGULATION ON FOREIGN INVESTMENT RESTRICTIONS AND NOMINEE PRACTICES IN INDONESIA

    Directory of Open Access Journals (Sweden)

    David Kairupan

    2014-03-01

    Full Text Available Certain provisions of Presidential Regulation No. 36 of 2010 concerning Negative Investment List are not clearly stipulated. In relation to the restrictions of foreign investment in certain business sectors asspecified in the Negative Investment List Article 33 para. (1 and (2 of the 2007 Investment Law expressly prohibits investors from entering into any nominee shareholding documentation. Notwithstanding, manynominee shareholding practices are still employed in Indonesia, aiming to circumvent such restrictions.This paper addresses certain issues on Presidential Regulation No. 36 of 2010 and nominee shareholding practices in Indonesia. Beberapa ketentuan dalam peraturan Presiden No. 36 Tahun 2010 yang mengandung ketentuan Daftar Negatif Investasi tidak dirumuskan secara jelas. Sehubungan dengan pembatasan kepemilikan modal asing di beberapa sektor usaha, Pasal 33 ayat (1 dan (2 Undang-Undang Penanaman Modal No. 25 Tahun 2007 secara tegas melarang penanam modal membuat dokumen-dokumen yang terkait dengankepemilikan saham secara nominee. Namun demikian, praktik kepemilikan saham secara nominee masih sering dilakukan di Indonesia untuk menghindari pembatasan tersebut. Tulisan ini akan membahasbeberapa permasalahan yang berhubungan dengan Peraturan Presiden No. 36 Tahun 2010 dan praktek kepemilikan saham secara nominee di Indonesia.

  19. Thrombocytopenia in Preterm Infants with Intrauterine Growth Restriction

    Directory of Open Access Journals (Sweden)

    Matsuda,Miwa

    2008-10-01

    Full Text Available Sick preterm infants often have thrombocytopenia at birth, and this is often associated with intrauterine growth restriction (IUGR, or birth weights less than the 10th percentile. The pathogenesis of the thrombocytopenia and its importance in IUGR are still unclear. We studied the characteristics of preterm IUGR infants with thrombocytopenia. Twenty-seven singleton Japanese preterm IUGR infants were born between January 2002 and June 2007 at Okayama University Hospital. Infants with malformation, chromosomal abnormalities, alloimmune thrombocytopenia, sepsis, and maternal aspirin ingestion were excluded. The infants were divided into group A (n=8, which had thrombocytopenia within 72h after birth, and group B (n=19, which did not. There were significant differences in birth weight, head circumference, umbilical artery (UA-pulsatility index (PI, middle cerebral artery-PI, UA-pH, UA-pO2, and UA-pCO2. The infants in group A were smaller, had abnormal blood flow patterns, and were hypoxic at birth. We speculate that the infants with thrombocytopenia were more severely growth-restricted by chronic hypoxia. Thrombocytopenia is an important parameter for chronic hypoxia in the uterine.

  20. DOE Land Disposal Restrictions Strategy Report for Radioactive Mixed Waste

    International Nuclear Information System (INIS)

    This report represents an effort by the Department of Energy (DOE) and its contractors to develop a strategy for achieving radioactive mixed waste (RMW) compliance with the Resource Conservation and Recovery Act (RCRA) Land Disposal Restrictions (LDR). Preliminary information provided by the Operations Offices has been reviewed to formulate an overall strategy that will enable DOE operations to comply with the Land Disposal Restrictions. The effort has concluded that all DOE Operations Offices are impacted by LDR due to the inability to meet existing and future LDR storage prohibition requirements or treatment standards for RMW. A total of 178 RMW streams subject to LDR are identified in this report. Quantities of RMW impacted by LDR have been estimated at approximately 710,785 cubic meters. DOE must place a high priority on resolving LDR compliance issues. Failure to resolve these issues could result in the curtailment of waste generating operations at DOE facilities. Actions will be required from both DOE (Headquarters and Operations Offices) and EPA in order to achieve DOE complex-wide compliance. Specific recommendations are included. 1 fig., 4 tabs

  1. Sildenafil citrate and uteroplacental perfusion in fetal growth restriction

    Directory of Open Access Journals (Sweden)

    Marzieh Vahid Dastjerdi

    2012-01-01

    Full Text Available Background: To determine whether the phosphodiesterase type 5 inhibitor, Sildenafil citrate, affects uteroplacental perfusion. Materials and Methods: Based on a randomized double-blinded and placebo-controlled trial, forty one pregnant women with documented intrauterine growth retardation at 24-37 weeks of gestation were evaluated for the effect of a single dose of Sildenafil citrate on uteroplacental circulation as determined by Doppler ultrasound study of the umbilical and middle cerebral arteries. Statistical analysis included χ2 -test to compare proportions, and independent-samples t-test and paired student′s t-test to compare continuous variables. Results: Sildenafil group fetuses demonstrated a significant decrease in systolic/diastolic ratios (0.60 [SD 0.40] [95% Cl 0.37-0.84], P=0.000, and pulsatility index (0.12 [SD 0.15] [95% Cl 0.02-0.22], P=0.019 for the umbilical artery and a significant increase in middle cerebral artery pulsatility index (MCA PI (0.51 [SD 0.60] [95% Cl 0.16-0.85], P=0.008. Conclusion: Doppler velocimetry index values reflect decreased placental bed vascular resistance after Sildenafil. Sildenafil citrate can improve fetoplacental perfusion in pregnancies complicated by intrauterine growth restriction. It could be a potential therapeutic strategy to improve uteroplacental blood flow in pregnancies with fetal growth restriction (FGR.

  2. Next-generation phylogenomics using a Target Restricted Assembly Method.

    Science.gov (United States)

    Johnson, Kevin P; Walden, Kimberly K O; Robertson, Hugh M

    2013-01-01

    Next-generation sequencing technologies are revolutionizing the field of phylogenetics by making available genome scale data for a fraction of the cost of traditional targeted sequencing. One challenge will be to make use of these genomic level data without necessarily resorting to full-scale genome assembly and annotation, which is often time and labor intensive. Here we describe a technique, the Target Restricted Assembly Method (TRAM), in which the typical process of genome assembly and annotation is in essence reversed. Protein sequences of phylogenetically useful genes from a species within the group of interest are used as targets in tblastn searches of a data set from a lane of Illumina reads for a related species. Resulting blast hits are then assembled locally into contigs and these contigs are then aligned against the reference "cDNA" sequence to remove portions of the sequences that include introns. We illustrate the Target Restricted Assembly Method using genomic scale datasets for 20 species of lice (Insecta: Psocodea) to produce a test phylogenetic data set of 10 nuclear protein coding gene sequences. Given the advantages of using DNA instead of RNA, this technique is very cost effective and feasible given current technologies. PMID:23000819

  3. Restrictive metric regularity and generalized differential calculus in Banach spaces

    Directory of Open Access Journals (Sweden)

    Bingwu Wang

    2004-10-01

    Full Text Available We consider nonlinear mappings f:X→Y between Banach spaces and study the notion of restrictive metric regularity of f around some point x¯, that is, metric regularity of f from X into the metric space E=f(X. Some sufficient as well as necessary and sufficient conditions for restrictive metric regularity are obtained, which particularly include an extension of the classical Lyusternik-Graves theorem in the case when f is strictly differentiable at x¯ but its strict derivative ∇f(x¯ is not surjective. We develop applications of the results obtained and some other techniques in variational analysis to generalized differential calculus involving normal cones to nonsmooth and nonconvex sets, coderivatives of set-valued mappings, as well as first-order and second-order subdifferentials of extended real-valued functions.

  4. Low-resolution remeshing using the localized restricted voronoi diagram

    KAUST Repository

    Yan, Dongming

    2014-10-01

    A big problem in triangular remeshing is to generate meshes when the triangle size approaches the feature size in the mesh. The main obstacle for Centroidal Voronoi Tessellation (CVT)-based remeshing is to compute a suitable Voronoi diagram. In this paper, we introduce the localized restricted Voronoi diagram (LRVD) on mesh surfaces. The LRVD is an extension of the restricted Voronoi diagram (RVD), but it addresses the problem that the RVD can contain Voronoi regions that consist of multiple disjoint surface patches. Our definition ensures that each Voronoi cell in the LRVD is a single connected region. We show that the LRVD is a useful extension to improve several existing mesh-processing techniques, most importantly surface remeshing with a low number of vertices. While the LRVD and RVD are identical in most simple configurations, the LRVD is essential when sampling a mesh with a small number of points and for sampling surface areas that are in close proximity to other surface areas, e.g., nearby sheets. To compute the LRVD, we combine local discrete clustering with a global exact computation. © 1995-2012 IEEE.

  5. Microtubules restrict plastid sedimentation in protonemata of the moss Ceratodon

    Science.gov (United States)

    Schwuchow, J.; Sack, F. D.

    1994-01-01

    Apical cells of protonemata of the moss Ceratodon purpureus are unusual among plant cells with sedimentation in that only some amyloplasts sediment and these do not fall completely to the bottom of vertical cells. To determine whether the cytoskeleton restricts plastid sedimentation, the effects of amiprophos-methyl (APM) and cytochalasin D (CD) on plastid position were quantified. APM treatments of 30-60 min increased the plastid sedimentation that is normally seen along the length of untreated or control cells. Longer APM treatments often resulted in more dramatic plastid sedimentation, and in some cases almost all plastids sedimented to the lowermost point in the cell. In contrast, the microfilament inhibitor CD did not affect longitudinal plastid sedimentation compared to untreated cells, although it did disturb or eliminate plastid zonation in the tip. These data suggest that microtubules restrict the sedimentation of plastids along the length of the cell and that microtubules are load-bearing for all the plastids in the apical cell. This demonstrates the importance of the cytoskeleton in maintaining organelle position and cell organization against the force of gravity.

  6. Caloric restriction: beneficial effects on brain aging and Alzheimer's disease.

    Science.gov (United States)

    Van Cauwenberghe, Caroline; Vandendriessche, Charysse; Libert, Claude; Vandenbroucke, Roosmarijn E

    2016-08-01

    Dietary interventions such as caloric restriction (CR) extend lifespan and health span. Recent data from animal and human studies indicate that CR slows down the aging process, benefits general health, and improves memory performance. Caloric restriction also retards and slows down the progression of different age-related diseases, such as Alzheimer's disease. However, the specific molecular basis of these effects remains unclear. A better understanding of the pathways underlying these effects could pave the way to novel preventive or therapeutic strategies. In this review, we will discuss the mechanisms and effects of CR on aging and Alzheimer's disease. A potential alternative to CR as a lifestyle modification is the use of CR mimetics. These compounds mimic the biochemical and functional effects of CR without the need to reduce energy intake. We discuss the effect of two of the most investigated mimetics, resveratrol and rapamycin, on aging and their potential as Alzheimer's disease therapeutics. However, additional research will be needed to determine the safety, efficacy, and usability of CR and its mimetics before a general recommendation can be proposed to implement them. PMID:27240590

  7. Fetal growth restriction is associated with malaria in pregnancy

    DEFF Research Database (Denmark)

    Briand, Valérie; Saal, Jessica; Ghafari, Caline;

    2016-01-01

    BACKGROUND: Few studies have evaluated the effect of malaria on intrauterine growth restriction on the basis of the fetal growth rate, rather than just the small-for-gestational age z score. Here, we assessed the impact of malaria on IUGR, using data from a longitudinal, ultrasonography-based fol...... and late pregnancy on fetal growth. This stresses the importance of starting preventive measures against malaria as early as possible during pregnancy.......BACKGROUND: Few studies have evaluated the effect of malaria on intrauterine growth restriction on the basis of the fetal growth rate, rather than just the small-for-gestational age z score. Here, we assessed the impact of malaria on IUGR, using data from a longitudinal, ultrasonography......-based follow-up study of Beninese women. METHODS: A total of 1016 women were followed up from gestational week 17 to delivery. Malaria was detected every month. Women underwent ultrasonography 4 times for gestational age determination and fetal biometry. We assessed the effect of malaria on birth weight...

  8. Lifelong caloric restriction increases working memory in mice.

    Directory of Open Access Journals (Sweden)

    Angela Kuhla

    Full Text Available Caloric restriction (CR is argued to positively affect general health, longevity and the normally occurring age-related reduction of cognition. This issue is well examined, but most studies investigated the effect of short-term periods of CR. Herein, 4 weeks old female mice were fed caloric restricted for 4, 20 and especially for 74 weeks. CR mice received 60% of food eaten by their ad libitum (AL fed littermates, and all age-matched groups were behaviorally analyzed. The motor coordination, which was tested by rotarod/accelerod, decreased age-related, but was not influenced by the different periods of CR. In contrast, the age-related impairment of spontaneous locomotor activity and anxiety, both being evaluated by open field and by elevated plus maze test, was found aggravated by a lifelong CR. Measurement of cognitive performance with morris water maze showed that the working memory decreased age-related in AL mice, while a lifelong CR caused a better cognitive performance and resulted in a significantly better spatial memory upon 74 weeks CR feeding. However, a late-onset CR feeding in 66 weeks old mice did not ameliorate the working memory. Therefore, a lifelong CR seems to be necessary to improve working memory.

  9. Lifelong caloric restriction increases working memory in mice.

    Science.gov (United States)

    Kuhla, Angela; Lange, Sophie; Holzmann, Carsten; Maass, Fabian; Petersen, Jana; Vollmar, Brigitte; Wree, Andreas

    2013-01-01

    Caloric restriction (CR) is argued to positively affect general health, longevity and the normally occurring age-related reduction of cognition. This issue is well examined, but most studies investigated the effect of short-term periods of CR. Herein, 4 weeks old female mice were fed caloric restricted for 4, 20 and especially for 74 weeks. CR mice received 60% of food eaten by their ad libitum (AL) fed littermates, and all age-matched groups were behaviorally analyzed. The motor coordination, which was tested by rotarod/accelerod, decreased age-related, but was not influenced by the different periods of CR. In contrast, the age-related impairment of spontaneous locomotor activity and anxiety, both being evaluated by open field and by elevated plus maze test, was found aggravated by a lifelong CR. Measurement of cognitive performance with morris water maze showed that the working memory decreased age-related in AL mice, while a lifelong CR caused a better cognitive performance and resulted in a significantly better spatial memory upon 74 weeks CR feeding. However, a late-onset CR feeding in 66 weeks old mice did not ameliorate the working memory. Therefore, a lifelong CR seems to be necessary to improve working memory.

  10. Universal Restrictions on Syllable Structure: Evidence From Mandarin Chinese.

    Science.gov (United States)

    Zhao, Xu; Berent, Iris

    2016-08-01

    Across languages, certain onset clusters are systematically preferred (e.g., [Formula: see text], "[Formula: see text]" indicates preference), and speakers extend these preferences even to onsets that are unattested in their language. All such demonstrations, however, come from cluster-rich languages, so the observed preferences could reflect not universal linguistic restrictions but lexical analogy. To address this possibility, here, we turn to Mandarin Chinese-a cluster-poor language. We reasoned that, if people are sensitive to the onset hierarchy, then they should repair ill-formed onsets as better-formed ones [Formula: see text]-the worse formed the onset, the more likely its repair, hence, its misidentification. Results were consistent with this hypothesis, and they obtained irrespective of participants' experience with their second language (English). Nonetheless, the effect of syllable structure was strongly modulated by phonetic cues and task demands. These findings suggest that speakers might share broad phonological restrictions, but phonetic factors play a major role in their detection. PMID:25980969

  11. 75 FR 19885 - Restricted Areas and Danger Zone at Naval Station Mayport, FL

    Science.gov (United States)

    2010-04-16

    ... January 25, 2010, issue of the Federal Register (75 FR 3883), and its regulations.gov docket number is COE... Department of the Army, Corps of Engineers 33 CFR Part 334 Restricted Areas and Danger Zone at Naval Station... restricted area as well as establishing two new restricted areas and a new danger zone in the waters...

  12. 5 CFR 332.407 - Restriction of consideration to one sex.

    Science.gov (United States)

    2010-01-01

    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Restriction of consideration to one sex... Restriction of consideration to one sex. An appointing officer may not restrict his consideration of eligibles... competitive service to one sex, except in unusual circumstances when OPM finds the action justified....

  13. 7 CFR 319.37-12 - Prohibited articles accompanying restricted articles.

    Science.gov (United States)

    2010-01-01

    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Prohibited articles accompanying restricted articles... Stock, Plants, Roots, Bulbs, Seeds, and Other Plant Products 1,2 § 319.37-12 Prohibited articles accompanying restricted articles. A restricted article for importation into the United States shall not...

  14. 33 CFR 162.215 - Lake Tahoe, Nev.; restricted area adjacent to Nevada Beach.

    Science.gov (United States)

    2010-07-01

    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Lake Tahoe, Nev.; restricted area adjacent to Nevada Beach. 162.215 Section 162.215 Navigation and Navigable Waters COAST GUARD, DEPARTMENT... § 162.215 Lake Tahoe, Nev.; restricted area adjacent to Nevada Beach. (a) The restricted area....

  15. 48 CFR 27.404-2 - Limited rights data and restricted computer software.

    Science.gov (United States)

    2010-10-01

    ... restricted computer software. 27.404-2 Section 27.404-2 Federal Acquisition Regulations System FEDERAL... Copyrights 27.404-2 Limited rights data and restricted computer software. (a) General. The basic clause at 52... restricted computer software by withholding the data from the Government and instead delivering form,...

  16. The effect of energy restriction on satiation an satiety in obese and lean men

    NARCIS (Netherlands)

    Blom, W.A.M.; Stafleu, A.; Hendriks, H.F.J.

    2004-01-01

    Aims: To investigate how time-blinded obese and lean men compensate for a 3-day energy-restrictive diet. Methods: Subjects were randomly put on a three-day energy-restrictive (ER) (67% energy restriction) and a three-day energy-balanced (EB) diet, with a washout period of one month. Both diets were

  17. 22 CFR 51.64 - Special validation of passports for travel to restricted areas.

    Science.gov (United States)

    2010-04-01

    ... restricted areas. 51.64 Section 51.64 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS PASSPORTS Denial, Revocation, and Restriction of Passports § 51.64 Special validation of passports for... his or passport to permit its use for travel to, or use in, a restricted country or area....

  18. 29 CFR 790.20 - Right of employees to sue; restrictions on representative actions.

    Science.gov (United States)

    2010-07-01

    ... 29 Labor 3 2010-07-01 2010-07-01 false Right of employees to sue; restrictions on representative... 1938 Restrictions and Limitations on Employee Suits § 790.20 Right of employees to sue; restrictions on..., no longer permits an employee or employees to designate an agent or representative (other than...

  19. Characterizing Caregiver Responses to Restricted and Repetitive Behaviors in Toddlers with Autism Spectrum Disorder

    Science.gov (United States)

    Harrop, Clare; Gulsrud, Amanda; Shih, Wendy; Hovsepyan, Lilit; Kasari, Connie

    2016-01-01

    Restricted and repetitive behaviors are a core feature of autism spectrum disorder. This descriptive study documented the presence of restricted and repetitive behaviors in 85 toddlers with autism spectrum disorder as they interacted with their caregiver in a play interaction. For each child restricted and repetitive behavior, a caregiver…

  20. 76 FR 38047 - Defense Federal Acquisition Regulation Supplement; Extension of Restrictions on the Use of...

    Science.gov (United States)

    2011-06-29

    ... Regulation Supplement; Extension of Restrictions on the Use of Mandatory Arbitration Agreements (DFARS Case... restriction on the use of mandatory arbitration agreements, when awarding contracts that exceed $1 million, to... the contractor restricts its employees to arbitration for claims under title VII of the Civil...

  1. May a Public University Restrict Faculty Expression on Its Internet World Wide Web Sites? Academic Freedom and University Facility Use Restrictions.

    Science.gov (United States)

    Allred, Lisa R.

    1997-01-01

    Public university restriction of faculty expression on the institution's World Wide Web server is discussed based on recent Supreme Court decisions. It is proposed that in some circumstances, content-based restriction of faculty expression is permissible and will not violate the First Amendment academic freedom rights of faculty. (MSE)

  2. Methionine restriction fundamentally supports health by tightening epithelial barriers.

    Science.gov (United States)

    Mullin, James M; Skrovanek, Sonja M; Ramalingam, Arivudainambi; DiGuilio, Katherine M; Valenzano, Mary C

    2016-01-01

    Dietary methionine restriction (MR) has been found to affect one of the most primary tissue-level functions of an organism: the efficiency with which the epithelial linings of major organs separate the fluid compartments that they border. This process, epithelial barrier function, is basic for proper function of all organs, including the lung, liver, gastrointestinal tract, reproductive tract, blood-brain barrier, and kidney. Specifically, MR has been found to modify the protein composition of tight junctional complexes surrounding individual epithelial cells in a manner that renders the complexes less leaky. This has been observed in both a renal epithelial cell culture model and in gastrointestinal tissue. In both cases, MR increased the transepithelial electrical resistance across the epithelium, while decreasing passive leak of small nonelectrolytes. However, the specific target protein modifications involved were unique to each case. Overall, this provides an example of the primary level on which MR functions to modify, and improve, an organism.

  3. Approximate Message Passing with Restricted Boltzmann Machine Priors

    CERN Document Server

    Tramel, Eric W; Krzakala, Florent

    2015-01-01

    Approximate Message Passing (AMP) has been shown to be an excellent statistical approach to signal inference and compressed sensing problem. The AMP framework provides modularity in the choice of signal prior; here we propose a hierarchical form of the Gauss-Bernouilli prior which utilizes a Restricted Boltzmann Machine (RBM) trained on the signal support to push reconstruction performance beyond that of simple iid priors for signals whose support can be well represented by a trained binary RBM. We present and analyze two methods of RBM factorization and demonstrate how these affect signal reconstruction performance within our proposed algorithm. Finally, using the MNIST handwritten digit dataset, we show experimentally that using an RBM allows AMP to approach oracle-support performance.

  4. Approximate message passing with restricted Boltzmann machine priors

    Science.gov (United States)

    Tramel, Eric W.; Drémeau, Angélique; Krzakala, Florent

    2016-07-01

    Approximate message passing (AMP) has been shown to be an excellent statistical approach to signal inference and compressed sensing problems. The AMP framework provides modularity in the choice of signal prior; here we propose a hierarchical form of the Gauss-Bernoulli prior which utilizes a restricted Boltzmann machine (RBM) trained on the signal support to push reconstruction performance beyond that of simple i.i.d. priors for signals whose support can be well represented by a trained binary RBM. We present and analyze two methods of RBM factorization and demonstrate how these affect signal reconstruction performance within our proposed algorithm. Finally, using the MNIST handwritten digit dataset, we show experimentally that using an RBM allows AMP to approach oracle-support performance.

  5. Cell entry of lymphocytic choriomeningitis virus is restricted in myotubes.

    Science.gov (United States)

    Iwasaki, Masaharu; Urata, Shuzo; Cho, Yoshitake; Ngo, Nhi; de la Torre, Juan C

    2014-06-01

    In mice persistently infected since birth with the prototypic arenavirus lymphocytic choriomeningitis viurs, viral antigen and RNA are readily detected in most organs and cell types but remarkably absent in skeletal muscle. Here we report that mouse C2C12 myoblasts that are readily infected by LCMV, become highly refractory to LCMV infection upon their differentiation into myotubes. Myotube's resistance to LCMV was not due to an intracellular restriction of virus replication but rather an impaired cell entry mediated by the LCMV surface glycoprotein. Our findings provide an explanation for the observation that in LCMV carrier mice myotubes, which are constantly exposed to blood-containing virus, remain free of viral antigen and RNA despite myotubes express high levels of the LCMV receptor alpha dystroglycan and do not pose an intracellular blockade to LCMV multiplication.

  6. Restricted environmental stimulation technique improves human performance: rifle marksmanship.

    Science.gov (United States)

    Barabasz, A; Barabasz, M; Bauman, J

    1993-06-01

    This study controlled for relaxation and guided imagery confounds noted in much previous research on enhancement of human performance using the restricted environmental stimulation technique (REST). Dry flotation REST was used where subjects lay ("floated") on a salt-water-filled bladder in a sound-attenuated, light-free chamber. 9 men and 3 women in a rifle marksmanship training course, exposed to dry-flotation REST, showed significantly higher rifle marksmanship scores than the university students who as matched controls were exposed to relaxation (9 men and 3 women). Further, only the former showed a significant pre- to posttest improvement in scores, which suggests REST's positive effects on marksmanship go beyond the induction of relaxation by hypnosis. The results support hypotheses summarized in 1982 by Barabasz regarding potentiation by REST of internally generated imagery and subsequent improvement observed in a nonREST posttest environment. PMID:8321601

  7. Smoking in hotels: prevalence, and opinions about restrictions.

    Science.gov (United States)

    Semmonds, A; Bailey, K; Bentley, S; Chase, V; Fernando, S; Guruge, A; King, M; Tan, O M; Walsh, R

    1995-02-01

    Exposure to high levels of environmental tobacco smoke can occur in hotels. Controversy exists about smoking regulation on licensed premises. This survey of 138 people attending one of three Newcastle hotels during 1993 found that 57 per cent of respondents were nonsmokers. Fifty-eight per cent (95 per cent confidence interval (CI) 50 to 66 per cent) of respondents in these hotels believed their health was being adversely affected by other people's smoke in the hotel. Seventy per cent (CI 62 to 78 per cent), including half the smokers, were in favour of restriction of smoking in the hotels. Most preferred the establishment of smoke-free areas to the introduction of total smoking bans in hotels. The failure of hotels to regulate smoking suggests that a legislative approach is required. The case for legislation would be strengthened by a larger study elsewhere in Australia.

  8. Christmas cards workshop in a Restricted Access Ward

    Directory of Open Access Journals (Sweden)

    Teresa García

    2003-12-01

    Full Text Available The Christmas cards workshop is an intervention study made in the Restricted Access Ward (RAW of Hospital Gregorio Marañón (Madrid, in December 2001, from the 5th to the 22nd. The object of this study was to assess the effectiveness of this workshop to improve the quality of the RAW patients´ hospital day, through their participation. They made 47 cards, the mean per patient was 1,52. Participation: 91,2% of the patients that fulfilled the inclusion criteria. Drawings and texts alluded to the convict´s perspective of Christmas time, from their own experience. The Christmas cards were exhibited in the hospital and they also were sent to different penitentiary institutions in Madrid, to make the RAW known. The course “Education for health for interdisciplinary projects in penitentiary institutions” was the frame of this workshop.

  9. The restricted isometry property meets nonlinear approximation with redundant frames

    DEFF Research Database (Denmark)

    Gribonval, Rémi; Nielsen, Morten

    2013-01-01

    It is now well known that sparse or compressible vectors can be stably recovered from their low-dimensional projection, provided the projection matrix satisfies a Restricted Isometry Property (RIP). We establish new implications of the RIP with respect to nonlinear approximation in a Hilbert space...... with a redundant frame. The main ingredients of our approach are: a) Jackson and Bernstein inequalities, associated to the characterization of certain approximation spaces with interpolation spaces; b) a proof that for overcomplete frames which satisfy a Bernstein inequality, these interpolation spaces are nothing...... and consequently the error of best m-term approximation of a vector decays at a certain rate if, and only if, the vector admits a compressible expansion in the dictionary. Yet, it turns out that Bernstein estimates are extremely fragile. For mildly overcomplete dictionaries with a one-dimensional kernel, we give...

  10. Polygons in restricted geometries subjected to infinite forces

    Science.gov (United States)

    Beaton, N. R.; Eng, J. W.; Soteros, C. E.

    2016-10-01

    We consider self-avoiding polygons in a restricted geometry, namely an infinite L × M tube in {{{Z}}}3. These polygons are subjected to a force f, parallel to the infinite axis of the tube. When f\\gt 0 the force stretches the polygons, while when f\\lt 0 the force is compressive. We obtain and prove the asymptotic form of the free energy in both limits f\\to +/- ∞ . We conjecture that the f\\to -∞ asymptote is the same as the limiting free energy of ‘Hamiltonian’ polygons, polygons which visit every vertex in a L× M× N box. We investigate such polygons, and in particular use a transfer-matrix methodology to establish that the conjecture is true for some small tube sizes. Dedicated to Anthony J Guttmann on the occasion of his 70th birthday.

  11. Restricted mouth opening and trismus in oral oncology.

    Science.gov (United States)

    Satheeshkumar, P S; Mohan, Minu P; Jacob, Jayan

    2014-06-01

    Restricted mouth opening (RMO) and trismus are terms commonly used in oral oncology in instances where there is difficulty in mouth opening. The term trismus in oral oncology is mainly used to indicate the radiation-induced fibrosis of the muscles of mastication. The treatment given for RMO as reported in the literature is given for muscular dysfunction trismus, whereas RMO in oral oncology can occur owing to various reasons other than muscular dysfunction. RMO occurs in various conditions of the oral cavity; in posterior pharyngeal infection, where it is termed reflectory trismus; in oral submucous fibrosis; in oral mucosal disorders; in the use of certain drugs; and in minor dental procedures of the posterior oral cavity. The usage of the term trismus in all RMO cases would complicate the treatment; thus, the word should not be used in all RMO cases.

  12. Dynamical Aspects of an Equilateral Restricted Four-Body Problem

    Directory of Open Access Journals (Sweden)

    Martha Álvarez-Ramírez

    2009-01-01

    that the two masses of the primaries m2 and m3 are equal to μ and the mass m1 is 1−2μ. The Hamiltonian function that governs the motion of the fourth mass is derived and it has three degrees of freedom depending periodically on time. Using a synodical system, we fixed the primaries in order to eliminate the time dependence. Similarly to the circular restricted three-body problem, we obtain a first integral of motion. With the help of the Hamiltonian structure, we characterize the region of the possible motions and the surface of fixed level in the spatial as well as in the planar case. Among other things, we verify that the number of equilibrium solutions depends upon the masses, also we show the existence of periodic solutions by different methods in the planar case.

  13. A New Method of Improving Transformer Restricted Earth Fault Protection

    Directory of Open Access Journals (Sweden)

    KRSTIVOJEVIC, J. P.

    2014-08-01

    Full Text Available A new method of avoiding malfunctioning of the transformer restricted earth fault (REF protection is presented. Application of the proposed method would eliminate unnecessary operation of REF protection in the cases of faults outside protected zone of a transformer or a magnetizing inrush accompanied by current transformer (CT saturation. On the basis of laboratory measurements and simulations the paper presents a detailed performance assessment of the proposed method which is based on digital phase comparator. The obtained results show that the new method was stable and precise for all tested faults and that its application would allow making a clear and precise difference between an internal fault and: (i external fault or (ii magnetizing inrush. The proposed method would improve performance of REF protection and reduce probability of maloperation due to CT saturation. The new method is robust and characterized by high speed of operation and high reliability and security.

  14. Restriction enzyme maps of the macropodid herpesvirus 2 genome.

    Science.gov (United States)

    Johnson, M A; Whalley, J M

    1987-01-01

    The DNA of macropodid herpesvirus 2 (dorcopsis wallaby herpesvirus) was analysed using restriction enzymes and molecular cloning techniques. Sets of EcoRI and SalI clones were prepared which represented approximately 85 per cent of the genome, and these clones were used to map the DNA by double-digestion and hybridization experiments. Data on uncloned regions were obtained by analysing fragments excised from agarose gels, and terminal fragments were identified by exonuclease III digestion. The genome was shown to be approximately 135 kilobases (kb) long. It has a long unique sequence (95 kb) bounded by repeat sequences (5.5 kb) and joined at one end to a short unique sequence (15 kb) also bounded by repeat sequences (7.0 kb) in a manner similar to that of herpes simplex viruses 1 and 2. PMID:2889444

  15. The Liberalization of Notary Fees in Romania. Objectives and Restrictions

    Directory of Open Access Journals (Sweden)

    Florentina MOISESCU

    2013-03-01

    Full Text Available Minimum notary fees are the questionable regulatory feature of Romanian notary system. Classic latin notary system to which it belongs Romanian notary system is the most regulated and most restrictive of the four existing notary systems in the European Union. Notary fees are set by law. Notary is an unusual market activity when assessing service provision is not during but after the quality transpires. Minimum notary fees militate to ensure an adequate quality of notary services at an acceptable cost. In contrast, the liberalization of notary fees aims to increase competition among service providers to encourage professionals to act according to the principle of cost-effectiveness, increase quality or to offer innovative services practice the lowest prices. The purpose of writing is to assess the impact of price liberalization in Romania with reference to me deregulated Dutch notary system and similar systems similar to Romanian, the Belgian system and German system.

  16. Holographic Renyi Entropies and Restrictions on Higher Derivative Terms

    CERN Document Server

    Pastras, Georgios

    2015-01-01

    We perform a holographic calculation of the Entanglement R\\'enyi entropy $S_q(\\mu,\\lambda)$, for spherical entangling surfaces in boundary CFT's with Einstein-Gauss-Bonnet-Maxwell holographic gravitational duals. We find that for Gauss-Bonnet couplings $\\lambda$, larger than a specific value, but still allowed by causality, a violation of an inequality that R\\'enyi entropies must obey by definition occurs. This violation is related to the existence of negative entropy black holes and restricts the coefficient of the Gauss-Bonnet coupling in the bulk theory. Furthermore, we discover a distinction in the analytic structure of the analytic continuation of $S_q(\\mu,\\lambda)$, between negative and non-negative $\\lambda$, suggesting the existence of a phase transition.

  17. Matrices with restricted entries and q-analogues of permutations

    CERN Document Server

    Lewis, Joel Brewster; Morales, Alejandro H; Panova, Greta; Sam, Steven V; Zhang, Yan

    2010-01-01

    We study the functions that count matrices of given rank over a finite field with specified positions equal to zero. We show that these matrices are $q$-analogues of permutations with certain restricted values. We obtain a simple closed formula for the number of invertible matrices with zero diagonal, a $q$-analogue of derangements, and a curious relationship between invertible skew-symmetric matrices and invertible symmetric matrices with zero diagonal. In addition, we provide recursions to enumerate matrices and symmetric matrices with zero diagonal by rank, and we frame some of our results in the context of Lie theory. Finally, we provide a brief exposition of polynomiality results for enumeration questions related to those mentioned, and give several open questions.

  18. The road to deterministic matrices with the restricted isometry property

    CERN Document Server

    Bandeira, Afonso S; Mixon, Dustin G; Wong, Percy

    2012-01-01

    The restricted isometry property (RIP) is a well-known matrix condition that provides state-of-the-art reconstruction guarantees for compressed sensing. While random matrices are known to satisfy this property with high probability, deterministic constructions have found less success. In this paper, we consider various techniques for demonstrating RIP deterministically, some popular and some novel, and we evaluate their performance. In evaluating some techniques, we apply random matrix theory and inadvertently find a simple alternative proof that certain random matrices are RIP. Later, we propose a particular class of matrices as candidates for being RIP, namely, equiangular tight frames (ETFs). Using the known correspondence between real ETFs and strongly regular graphs, we investigate certain combinatorial implications of a real ETF being RIP. Specifically, we give probabilistic intuition for a new bound on the clique number of Paley graphs of prime order, and we conjecture that the corresponding ETFs are R...

  19. Annual Fasting; the Early Calories Restriction for Cancer Prevention

    Directory of Open Access Journals (Sweden)

    Solat Eslami

    2012-12-01

    Full Text Available Essentially, people’s diet and nutritional status has been changed substantially worldwide and several lines of evidence suggest that these changes are to the detriment of their health. Additionally, it has been well documented that unhealthy diet especially the fast foods, untraditional foods or bad-eating-habits influence the human gut microbiome. The gut microbiota shapes immune responses during human life and affects his/her metabolomic profiles. Furthermore, many studies highlight the molecular pathways that mediate host and symbiont interactions that regulate proper immune function and prevention of cancer in the body. Intriguingly, if cancer forms in a human body due to the weakness of immune system in detriment of microbiome, the removal of cancer stem cells can be carried out through early Calories Restriction with Annual Fasting (AF before tumor development or progress. Besides, fasting can b balance the gut microbiome for enhancement of immune system against cancer formation.

  20. Institutional violence towards Bolivian migrant woman. Marianism and mobility restriction

    Directory of Open Access Journals (Sweden)

    Virginia Maria Fuentes Gutiérrez

    2015-12-01

    Full Text Available In this paper we outline some of the research results of a larger work which studies the Bolivian migration from a gender perspective, as well as the impact of the institutional practices that determine the transnational experience. In a global scene of restrictive rules concerning the human mobility, we notice how control and dominance strategies are present in ideologies and symbolic mechanisms. Women options in the migration process are trapped through them. We propose to recognize the symbolic and institutional violence that pressures migrants during their migration journey, focusing on understanding the ideological content — sexism and marianism — in which they are based on. We present an analysis of the instrumented ways of applying violence against Bolivian migrant women and its families from the social action practices implemented at origin and destination (transnational perspective.

  1. Classifying orbits in the restricted three-body problem

    CERN Document Server

    Zotos, Euaggelos E

    2015-01-01

    The case of the planar circular restricted three-body problem is used as a test field in order to determine the character of the orbits of a small body which moves under the gravitational influence of the two heavy primary bodies. We conduct a thorough numerical analysis on the phase space mixing by classifying initial conditions of orbits and distinguishing between three types of motion: (i) bounded, (ii) escape and (iii) collisional. The presented outcomes reveal the high complexity of this dynamical system. Furthermore, our numerical analysis shows a remarkable presence of fractal basin boundaries along all the escape regimes. Interpreting the collisional motion as leaking in the phase space we related our results to both chaotic scattering and the theory of leaking Hamiltonian systems. We also determined the escape and collisional basins and computed the corresponding escape/collisional times. We hope our contribution to be useful for a further understanding of the escape and collisional mechanism of orbi...

  2. Enhanced Nephrogenesis In Offspring of Water Restricted Rat Dams

    Science.gov (United States)

    Mansano, Roy; Desai, Mina; Garg, Ambica; Choi, Gyu Yeon; Ross, Michael G.

    2008-01-01

    Objective Maternal water restriction (WR) may induce offspring plasma hypertonicity and enhanced vasopressin secretory responses. We determined effects of pregnancy WR on offspring body composition, renal morphology and blood pressure. Study Design Pregnant Sprague Dawley rats (n=21) were randomized to WR, pair-fed (PF) and control from embryo day (e) 10–21. Offspring body and organ weights and glomelular number and size were measured at birth and at 21 days of age. At 6 and 9 weeks, offspring blood pressure was determined. Results At 21 days of age, WR offspring glomerular number was increased (17%; p<0.05), while PF glomerular number was lower (4%) compared to controls. Systolic blood pressures were elevated in both WR and PF at both 6 and 9 weeks. Conclusions Pregnancy WR stimulates offspring nephrogenesis, suggesting an adaptive response to future dehydration. Programmed hypertension in WR and PF groups likely occurs via different mechanisms. PMID:17466712

  3. Visual expression of the experiences of restrictive eating

    DEFF Research Database (Denmark)

    Mark, Edith

    Background of the research: Visual methods are used in nursing research. These methods include media such as film, video, still images, material artifacts and drawing. The current study is a PhD project, dealing with children's experiences of eating restrictively (diabetes or obesity). Visual...... methods were used as a complement to qualitative research methods (e.g., interviews) in an effort to explore and identify children's perceptions of life situation. Purpose for the presentation: Presenting the use of visual methods as a research tool in the phenomenological nursing research...... and as an option in the dialogue with the patient. Material and method description: Drawing, modeling and role-playing with stuffed animals is part of the material from the study and illustrate how visual methods can be used in relationship with the child. Result: The play and creativity have a function...

  4. Dialogical nursing ethics: the quality of freedom restrictions.

    Science.gov (United States)

    Abma, Tineke A; Widdershoven, Guy A M; Frederiks, Brenda J M; van Hooren, Rob H; van Wijmen, Frans; Curfs, Paul L M G

    2008-11-01

    This article deals with the question of how ethicists respond to practical moral problems emerging in health care practices. Do they remain distanced, taking on the role of an expert, or do they become engaged with nurses and other participants in practice and jointly develop contextualized insights about good care? A basic assumption of dialogical ethics entails that the definition of good care and what it means to be a good nurse is a collaborative product of ongoing dialogues among various stakeholders engaged in the practice. This article discusses the value of a dialogical approach to ethics by drawing on the work of various nursing scholars. We present a case example concerning the quality of freedom restrictions for intellectually disabled people. Issues for discussion include the role and required competences of the ethicist and dealing with asymmetrical relationships between stakeholders. PMID:18849368

  5. Complexity of Propositional Abduction for Restricted Sets of Boolean Functions

    CERN Document Server

    Creignou, Nadia; Thomas, Michael

    2009-01-01

    Abduction is a fundamental and important form of non-monotonic reasoning. Given a knowledge base explaining how the world behaves it aims at finding an explanation for some observed manifestation. In this paper we focus on propositional abduction, where the knowledge base and the manifestation are represented by propositional formulae. The problem of deciding whether there exists an explanation has been shown to be SigmaP2-complete in general. We consider variants obtained by restricting the allowed connectives in the formulae to certain sets of Boolean functions. We give a complete classification of the complexity for all considerable sets of Boolean functions. In this way, we identify easier cases, namely NP-complete and polynomial cases; and we highlight sources of intractability. Further, we address the problem of counting the explanations and draw a complete picture for the counting complexity.

  6. Pathogen prevalence and microbial levels associated with restricted shell eggs.

    Science.gov (United States)

    Jones, D R; Musgrove, M T

    2007-09-01

    Restricted shell eggs that do not meet quality standards for retail but maintain acceptable quality for inclusion in further processed eggs are often diverted to further processing. A study was conducted to characterize the microbiological populations present on and in these eggs. On a single day, restricted eggs were collected from three shell egg processing plants a total of three times (replicates). Six shells or egg contents were combined to create a pool. Ten pools of shells and contents were formed for each plant per replicate. Shells and membranes were macerated in 60 ml of diluent. Contents were stomacher blended to form a homogeneous mixture. Total aerobic microorganisms and Enterobacteriaceae were enumerated. The prevalence of Salmonella, Campylobacter, and Listeria was determined by cultural methods. Average aerobic counts were 4.3 log CFU/ml for the shells and 2.0 log CFU/ml for the contents. There were plant x replicate differences for both (P shell was 2.4 log CFU/ml and less than 0.1 log CFU/ml for the egg contents, with 36.7% of the samples being positive. One shell sample (0.5% of total samples) was Campylobacter positive. Two shell samples (1.1% of total samples) were Salmonella positive. Twenty-one percent of samples were positive for Listeria (33 shells and 5 contents). Although current pasteurization guidelines are based on Salmonella lethality, the results of this study reiterate the need to revisit the guidelines to determine the effectiveness for other pathogenic species. PMID:17900075

  7. Doppler prediction of adverse perinatal outcome in intrauterine growth restriction

    Directory of Open Access Journals (Sweden)

    Nina Mahale

    2015-02-01

    Full Text Available Background: Objective of current study was to determine and compare the diagnostic performance of Doppler ultrasonography of the fetal Middle Cerebral Artery (MCA and Umbilical Artery (UA for prediction of adverse perinatal outcome in suspected intrauterine growth restriction (IUGR. Methods: Fifty singleton pregnancies in third trimester of pregnancy with suspected intrauterine growth restriction were examined with Doppler ultrasonography of fetal MCA and UA. Results: Twenty patients of the fifty included patients had at least one major or minor adverse outcome. Major adverse outcome included perinatal deaths which included both intrauterine deaths and early neonatal deaths, hypoxic ischemic encephalopathy, intraventricular hemorrhage, periventricular leukomalacia, pulmonary hemorrhage, necrotizing enterocolitis and septicemia. Minor outcomes included cesarean section for fetal distress, Apgar score below 7 at 5 minutes and admission to Neonatal Intensive Care Unit (NICU for treatment. MCA PI is the most sensitive(90% index in predicting any adverse perinatal outcome i.e. including both major and minor outcomes, Positive Predictive Value (PPV and specificity being greatest for MCA/UA PI (96.6%, 93.7%. For the major adverse outcome most sensitive (86.6% most specific (91.4% and with highest PPV (81.2% and NPV (94.1%, is MCA/UA PI. Ratio of MCA/UAPI is more sensitive (90% than PI of both the arteries alone for overall prediction of adverse perinatal outcome. Conclusions: Thus we conclude that the Doppler studies of the multiple vessels in the fetoplacental unit can help in the monitoring of the compromised fetus and can help us predicting neonatal morbidity. This may be helpful in determining the optimal time of deliveries in pregnancies complicated by IUGR. [Int J Reprod Contracept Obstet Gynecol 2015; 4(1.000: 119-130

  8. Gestational protein restriction alters cell proliferation in rat placenta.

    Science.gov (United States)

    Rebelato, Hércules Jonas; Esquisatto, Marcelo Augusto Marreto; de Sousa Righi, Eloá Fernanda; Catisti, Rosana

    2016-04-01

    We recently showed that gestational protein restriction (GPR) alters the structure of the rat placenta on day 19 of gestation (dG). The aim of the study was to investigate the spatial and temporal immunolocalization of proliferating cell antigen Ki67 in normal and GPR placental development. Pregnant Wistar rats were divided into two groups: normal (NP, 17 % casein) or low-protein diet (LP, 6 % casein). Placentas and fetus were collected and weighed at 15, 17, 19 and 21 dG. Morphological, morphometric and ultrastructural analyses were performed. Immunoperoxidase was used to identify nuclear antigen Ki67 in placental sections. We observed a significant reduction in the number of trophoblast giant cells and glycogen cells in the LP group. Placental weight was significantly reduced only at 17 dG in the LP group, in parallel to a decrease in glycogen cells. From 15 to 21 dG, the thickness of the junctional zone (JZ) decreased in NP and LP animals, while that of the labyrinth zone (LZ) increased in parallel to a reduction in the number of proliferating cells in this LZ zone. GPR significantly inhibits cell proliferation in the JZ, especially at 15 and 17 dG. The ultrastructural appearance of the cytoplasm of giant and cytotrophoblastic cells indicates degeneration from 15 to 21 dG and this effect is enhanced in LP animals suggesting early aging. Offspring of NP dams were significantly heavier than offspring of LP dams at 21 dG. GPR causes modifications in specific regions of the placenta, cell proliferation inhibition and fetal growth restriction.

  9. Selective cognitive empathy deficit in adolescents with restrictive anorexia nervosa

    Directory of Open Access Journals (Sweden)

    Calderoni S

    2013-10-01

    Full Text Available Sara Calderoni,1 Pamela Fantozzi,1 Sandra Maestro,1 Elena Brunori,1 Antonio Narzisi,1 Giulia Balboni,2 Filippo Muratori1,31Department of Child Neurology and Psychiatry, IRCCS Stella Maris Foundation, 2Department of Surgery, Medical, Molecular and Critical Area Pathology, University of Pisa, 3Department of Developmental Medicine, University of Pisa, Pisa, ItalyBackground: A growing, but conflicting body of literature suggests altered empathic abilities in subjects with anorexia nervosa-restricting type (AN-R. This study aims to characterize the cognitive and affective empathic profiles of adolescents with purely AN-R.Methods: As part of a standardized clinical and research protocol, the Interpersonal Reactivity Index (IRI, a valid and reliable self-reported instrument to measure empathy, was administered to 32 female adolescents with AN-R and in 41 healthy controls (HC comparisons, matched for age and gender. Correlational analyses were performed to evaluate the links between empathy scores and psychopathological measures.Results: Patients scored significantly lower than HC on cognitive empathy (CE, while they did not differ from controls on affective empathy (AE. The deficit in CE was not related to either disease severity nor was it related to associated psychopathology.Conclusion: These results, albeit preliminary, suggest that a dysfunctional pattern of CE capacity may be a stable trait of AN-R that should be taken into account not only for the clinical management, but also in preventive and therapeutic intervention.Keywords: anorexia nervosa-restricting type, cognitive empathy, affective empathy, female adolescents, Interpersonal Reactivity Index

  10. The emergence of complexity and restricted pleiotropy in adapting networks

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    Le Nagard Hervé

    2011-11-01

    Full Text Available Abstract Background The emergence of organismal complexity has been a difficult subject for researchers because it is not readily amenable to investigation by experimental approaches. Complexity has a myriad of untested definitions and our understanding of its evolution comes primarily from static snapshots gleaned from organisms ranked on an intuitive scale. Fisher's geometric model of adaptation, which defines complexity as the number of phenotypes an organism exposes to natural selection, provides a theoretical framework to study complexity. Yet investigations of this model reveal phenotypic complexity as costly and therefore unlikely to emerge. Results We have developed a computational approach to study the emergence of complexity by subjecting neural networks to adaptive evolution in environments exacting different levels of demands. We monitored complexity by a variety of metrics. Top down metrics derived from Fisher's geometric model correlated better with the environmental demands than bottom up ones such as network size. Phenotypic complexity was found to increase towards an environment-dependent level through the emergence of restricted pleiotropy. Such pleiotropy, which confined the action of mutations to only a subset of traits, better tuned phenotypes in challenging environments. However, restricted pleiotropy also came at a cost in the form of a higher genetic load, as it required the maintenance by natural selection of more independent traits. Consequently, networks of different sizes converged in complexity when facing similar environment. Conclusions Phenotypic complexity evolved as a function of the demands of the selective pressures, rather than the physical properties of the network architecture, such as functional size. Our results show that complexity may be more predictable, and understandable, if analyzed from the perspective of the integrated task the organism performs, rather than the physical architecture used to

  11. Jasmonate-dependent plant defense restricts thrips performance and preference

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    Seo Shigemi

    2009-07-01

    Full Text Available Abstract Background The western flower thrips (Frankliniella occidentalis [Pergande] is one of the most important insect herbivores of cultivated plants. However, no pesticide provides complete control of this species, and insecticide resistance has emerged around the world. We previously reported the important role of jasmonate (JA in the plant's immediate response to thrips feeding by using an Arabidopsis leaf disc system. In this study, as the first step toward practical use of JA in thrips control, we analyzed the effect of JA-regulated Arabidopsis defense at the whole plant level on thrips behavior and life cycle at the population level over an extended period. We also studied the effectiveness of JA-regulated plant defense on thrips damage in Chinese cabbage (Brassica rapa subsp. pekinensis. Results Thrips oviposited more on Arabidopsis JA-insensitive coi1-1 mutants than on WT plants, and the population density of the following thrips generation increased on coi1-1 mutants. Moreover, thrips preferred coi1-1 mutants more than WT plants. Application of JA to WT plants before thrips attack decreased the thrips population. To analyze these important functions of JA in a brassica crop plant, we analyzed the expression of marker genes for JA response in B. rapa. Thrips feeding induced expression of these marker genes and significantly increased the JA content in B. rapa. Application of JA to B. rapa enhanced plant resistance to thrips, restricted oviposition, and reduced the population density of the following generation. Conclusion Our results indicate that the JA-regulated plant defense restricts thrips performance and preference, and plays an important role in the resistance of Arabidopsis and B. rapa to thrips damage.

  12. Comparison of a Restricted and Unrestricted Vegan Diet Plan with a Restricted Omnivorous Diet Plan on Health-Specific Measures

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    Richard J. Bloomer

    2015-07-01

    Full Text Available Background: We have previously noted beneficial health outcomes when individuals follow a dietary restriction plan in accordance with the Daniel Fast (DF. This is true whether individuals eliminate all animal products or include small amounts of meat and dairy in their plan. The present study sought to compare anthropometric and biochemical measures of health in individuals following a traditional DF (i.e., restricted vegan or modified DF (i.e., restricted omnivorous; inclusive of ad libitum meat and skim milk consumption, with those following an unrestricted vegan diet plan. Methods: 35 subjects (six men; 29 women; 33 ± 2 years; range: 18–67 years completed a 21-day diet plan. Subjects reported to the lab for pre- (day 1 and post-intervention testing (day 22 in a 10 h fasted state. Blood samples were collected and assayed for complete blood count, metabolic panel, lipid panel, insulin, HOMA-IR, C-reactive protein, and oxidative stress biomarkers (malondialdehyde, advanced oxidation protein products, and nitrate/nitrite. Heart rate and blood pressure were measured and body composition was determined via dual energy X-ray absorptiometry. Subjects’ self-reported compliance, mental and physical health, and satiety in relation to the dietary modification were recorded. Results: No interaction effects were noted for our outcome measures (p > 0.05. However, subjects in the traditional DF group reported an approximate 10% increase in perceived mental and physical health, with a 25% reduction in malondialdehyde and a 33% reduction in blood insulin. Systolic BP was reduced approximately 7 mmHg in subjects assigned to the traditional DF, with an approximate 5 mmHg reduction in subjects assigned to the modified DF and the unrestricted vegan plan. A small (2 mmHg reduction in diastolic BP was noted for subjects in both DF groups; a slight increase in diastolic BP was noted for subjects assigned to the unrestricted vegan group. An approximate 20

  13. Down-regulation of the cardiac sarcoplasmic reticulum ryanodine channel in severely food-restricted rats

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    V.A. Vizotto

    2007-01-01

    Full Text Available We have shown that myocardial dysfunction induced by food restriction is related to calcium handling. Although cardiac function is depressed in food-restricted animals, there is limited information about the molecular mechanisms that lead to this abnormality. The present study evaluated the effects of food restriction on calcium cycling, focusing on sarcoplasmic Ca2+-ATPase (SERCA2, phospholamban (PLB, and ryanodine channel (RYR2 mRNA expressions in rat myocardium. Male Wistar-Kyoto rats, 60 days old, were submitted to ad libitum feeding (control rats or 50% diet restriction for 90 days. The levels of left ventricle SERCA2, PLB, and RYR2 were measured using semi-quantitative RT-PCR. Body and ventricular weights were reduced in 50% food-restricted animals. RYR2 mRNA was significantly decreased in the left ventricle of the food-restricted group (control = 5.92 ± 0.48 vs food-restricted group = 4.84 ± 0.33, P < 0.01. The levels of SERCA2 and PLB mRNA were similar between groups (control = 8.38 ± 0.44 vs food-restricted group = 7.96 ± 0.45, and control = 1.52 ± 0.06 vs food-restricted group = 1.53 ± 0.10, respectively. Down-regulation of RYR2 mRNA expressions suggests that chronic food restriction promotes abnormalities in sarcoplasmic reticulum Ca2+ release.

  14. Initial test of an emotional avoidance model of restriction in anorexia nervosa using ecological momentary assessment.

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    Haynos, Ann F; Crosby, Ross D; Engel, Scott G; Lavender, Jason M; Wonderlich, Stephen A; Mitchell, James E; Peterson, Carol B; Crow, Scott J; Le Grange, Daniel

    2015-09-01

    It has been hypothesized that restrictive eating allows individuals with anorexia nervosa (AN) to avoid contact with negative emotions; however, this presumption has not been directly tested. In this study, we conducted an initial investigation examining whether restrictive eating serves an emotional avoidance function among individuals with AN. Females with AN (n = 118) reported on negative and positive affect, anxiety/tension, and eating behaviors at multiple time points daily over a 2-week period using ecological momentary assessment methodology. Affective patterns were compared using generalized estimating equation models between days in which participants reported either: (1) relatively high restriction (without binge eating); (2) relatively low restriction (without binge eating); (3) binge eating; or (4) no restriction or binge eating. We hypothesized that, if restriction were functioning to avoid negative affect, average negative affect and anxiety/tension, as well as average negative and positive affect lability, would be lower and average positive affect would be higher on days characterized by high levels of restriction compared to other eating patterns. Contrary to hypotheses: (1) average negative affect, anxiety/tension, and positive affect were not significantly different between days characterized by high restriction and those characterized by low or no restriction; (2) Negative affect and anxiety/tension lability were higher on days characterized by high restriction compared to no restriction or binge eating days; (3) Anxiety/tension lability was higher on days characterized by high versus low levels of restriction. This patterns of findings does not support an avoidance model of restrictive eating for individuals with AN. PMID:26228412

  15. The future of irrigated agriculture under environmental flow requirements restrictions

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    Pastor, Amandine; Palazzo, Amanda; Havlik, Petr; Kabat, Pavel; Obersteiner, Michael; Ludwig, Fulco

    2016-04-01

    Water is not an infinite resource and demand from irrigation, household and industry is constantly increasing. This study focused on including global water availability including environmental flow requirements with water withdrawal from irrigation and other sectors at a monthly time-step in the GLOBIOM model. This model allows re-adjustment of land-use allocation, crop management, consumption and international trade. The GLOBIOM model induces an endogenous change in water price depending on water supply and demand. In this study, the focus was on how the inclusion of water resources affects land-use and, in particular, how global change will influence repartition of irrigated and rainfed lands at global scale. We used the climate change scenario including a radiative forcing of 8.5 W/m2 (RCP8.5), the socio-economic scenario (SSP2: middle-of-road), and the environmental flow method based on monthly flow allocation (the Variable Monthly Flow method) with high and low restrictions. Irrigation withdrawals were adjusted to a monthly time-step to account for biophysical water limitations at finer time resolution. Our results show that irrigated land might decrease up to 40% on average depending on the choice of EFR restrictions. Several areas were identified as future hot-spots of water stress such as the Mediterranean and Middle-East regions. Other countries were identified to be in safe position in terms of water stress such as North-European countries. Re-allocation of rainfed and irrigated land might be useful information for land-use planners and water managers at an international level to decide on appropriate legislations on climate change mitigation/adaptation when exposure and sensitivity to climate change is high and/or on adaptation measures to face increasing water demand. For example, some countries are likely to adopt measures to increase their water use efficiencies (irrigation system, soil and water conservation practices) to face water shortages, while

  16. Role of Doppler Velocimetry in growth restricted fetuses

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    Dr. Khushali Gandhi

    2015-01-01

    Full Text Available Background Intra Uterine Growth Restriction (IUGR is an important and particularly challenging problem for obstetricians and pediatricians. IUGR is a leading contributor in perinatal morbidity and mortality affecting 23.8% newborns around the world and 75% are born in Asia alone. In India the incidence of low birth weight varies from 15 to 25% and more than 50% of them are IUGR. Methods The present article consists of a study of 100 cases of intrauterine growth restriction with periodic color Doppler during the period of 1st July 2011 to 30 th August, 2013 in Obstetrics and Gynecology Department of a tertiary care center. Detail history taken. General and obstetrical examination was done along with routine hematological and urine investigations. Ultrasound examination was done for growth, liquor and placental localization. Fetal well- being was assessed with Doppler studies and daily fetal movement count. Results In present study moderate to severe pregnancy induced hypertension (53.9% and lack of proper weight gain (23% are found to be the commonest causes of IUGR. Out of 69 IUGR cases having abnormal Doppler, about 63.8% had abnormality in uterine artery flow, 85.5% had abnormality in umbilical artery flow, 88.4% had abnormality in middle cerebral artery flow, 55% had abnormality in uterine and umbilical artery and 75.4% had abnormality in umbilical artery and MCA. Incidence of fetal demise (13% was higher in patients with abnormal Doppler flow compared to normal flow (3.2%. Surgical intervention in form of caesarean was required in 69.6% of patients with abnormal Doppler flow. Cerebro-placental ratio (CPR 1 where fetal demise is 2.6%. Incidence of AEDF/REDF ( Absent End Diastolic flow/Reversed End diastolic flow in IUGR was 8% that resulted in 50% loss of fetus. Conclusions Color Doppler is a useful mode to predict fetal outcome in IUGR. Color Doppler allows better understandings of hemodynamic changes in feto- placental and utero

  17. Alteration of the Specificity of PstⅠRestriction Endonuclease

    Institute of Scientific and Technical Information of China (English)

    2000-01-01

    The influence of factors on the substrate-specificity of Pst Ⅰ restriction endonuclease has been studied with the method of electrophoresis. The results show that, the specificity of Pst Ⅰ almost can not be influenced by the single alteration of the concentration of Tris*HCl, Mg2+ or Na+ in the reaction system, but it can be altered by the reduction of any two of them. The specificity can not be altered by the single alteration of pH or the replacement of Mg2+ with Mn2+. The addition of glycerol or dimethylsulphoxide (DMSO) to the reaction system results in the relaxation of the substrate-specificity of Pst Ⅰ , but dimethylmethylformide, glycol and ethyl alcohol can not bring about the alteration of Pst Ⅰ specificity. Through the method of cloning and sequencing, the nucleotides of No.1 and 6 in the recognition sequence of Pst Ⅰ have changed (1C→A or 6G→T). Used with the enzyme analysis of an artificially synthetic DNA segment containing a special sequence, the nucleotides of No.1 and 6 have both changed (1C→A and 6G→T). The recognition sequence of Pst Ⅰ is speculated to be changed from CTGCA↓G to TGCA↓.

  18. The actions of restriction endonucleases on lampbrush chromosomes.

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    Gould, D C; Callan, H G; Thomas, C A

    1976-07-01

    Lampbrush chromosomes from oocytes of Notophthalmus viridescens were dispersed in media containing restriction endonucleases isolated from Haemophilus and E. coli. These endonucleases cleave duplex DNAs at specific palindromic sequences of nucleotides, and several sensitive sites occur per micron of DNA. The overwhelming majority of the lateral loops of lampbrush chromosomes are extensively fragmented by these endonucleases, but an occasional pair of loops is refractory. A notable example of loops showing this refractory property are the giant loops on chromosome II in the presence of Hae. These loops, whose DNA-containing axes are several hundred micra long, are sensitive to other nucleases such as EcoB, endonuclease I and pancreatic DNase I; their refractory behavior towards Hae therefore indicates that the sequence sensitive to this particular endonuclease is systematically absent. This anomalous property can be comprehended if it be assumed that the axial DNA of the giant loops consists of tandem repeats of a sequence which happens not to include the sensitive site. PMID:987047

  19. Cacao in México: Restrictive factors and productivity levels

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    Julio Díaz-José

    2014-12-01

    Full Text Available Cacao (Theobroma cacao L. represents one of the most important agricultural crops of the humid Mexican tropics. In the last 10 yr, approximately 23.000 t of this grain were no longer produced per cycle. The objective of this study was to identify characteristics and factors that restrict production in the states of Tabasco and Chiapas. A survey was applied to obtain information about 184 producers and their plantations by two-stage sampling. Descriptive statistics were calculated and multilevel models were adjusted to analyze the information. Results show that there are differences (P < 0.05 in cacao yield between municipalities (380 kg ha-1 + u,o j is the estimated residual for each municipality. Crop productivity levels are higher in the state of Tabasco than in Chiapas (644 and 344 kg ha-1, respectively. Incidence of frosty pod rot of cacoa, also known as moniliasis, induced by Moniliophthora roreri [(Cif H.C. Evans, Stalpers, Samson & Benny 1978] is significantly greater (P < 0.05 in the state of Chiapas (60% than in Tabasco (48%.Producers who carry out more crop management practices increase yields and decrease the pathogen's impact on their plantations. Results suggest the need to apply differentiated public policies to promote production within each region or municipality.

  20. Dietary restriction, mitochondrial function and aging: from yeast to humans.

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    Ruetenik, Andrea; Barrientos, Antoni

    2015-11-01

    Dietary restriction (DR) attenuates many detrimental effects of aging and consequently promotes health and increases longevity across organisms. While over the last 15 years extensive research has been devoted towards understanding the biology of aging, the precise mechanistic aspects of DR are yet to be settled. Abundant experimental evidence indicates that the DR effect on stimulating health impinges several metabolic and stress-resistance pathways. Downstream effects of these pathways include a reduction in cellular damage induced by oxidative stress, enhanced efficiency of mitochondrial functions and maintenance of mitochondrial dynamics and quality control, thereby attenuating age-related declines in mitochondrial function. However, the literature also accumulates conflicting evidence regarding how DR ameliorates mitochondrial performance and whether that is enough to slow age-dependent cellular and organismal deterioration. Here, we will summarize the current knowledge about how and to which extent the influence of different DR regimes on mitochondrial biogenesis and function contribute to postpone the detrimental effects of aging on health-span and lifespan. This article is part of a Special Issue entitled: Mitochondrial Dysfunction in Aging.