Sample records for admin restriction faq

  1. Leishmaniasis FAQs

    ... Tropical Diseases Laboratory Diagnostic Assistance [DPDx] Parasites Home Leishmaniasis FAQs Recommend on Facebook Tweet Share Compartir On ... leishmaniasis, could I get it again? What is leishmaniasis? Leishmaniasis is a parasitic disease that is found ...

  2. Infertility FAQ's

    ... 3286 After hours (404) 639-2888 Contact Media Infertility FAQs Recommend on Facebook Tweet Share Compartir Frequently Asked Questions What is infertility? In general, infertility is defined as not being ...

  3. Acanthamoeba Keratitis FAQs

    ... Amebic Encephalitis (GAE); Keratitis Parasites Home Share Compartir Acanthamoeba Keratitis FAQs On this Page What is Acanthamoeba ... developing Acanthamoeba keratitis? Infection of the Eye with Acanthamoeba What is Acanthamoeba keratitis? Acanthamoeba keratitis is a ...

  4. Enterobiasis (Pinworm Infection) FAQs

    ... Tropical Diseases Laboratory Diagnostic Assistance [DPDx] Parasites Home Pinworm Infection FAQs Recommend on Facebook Tweet Share Compartir ... infection and reinfection be prevented? What is a pinworm? A pinworm ("threadworm") is a small, thin, white ...

  5. Circovirus in Dogs FAQ

    ... Center Tools for K-12 Educators Circovirus in Dogs FAQ November 22, 2013 Update November 22, 2013: ... information. Canine circovirus infections have been documented in dogs with vomiting and diarrhea. The distribution of the ...

  6. Drinking Water FAQ

    ... your well Who should test your well Drinking Water FAQ Frequently Asked Questions General Where does my ... CDC's Private Wells page. Top of Page Public Water Systems What type of health issues can be ...

  7. Pelvic Pain: Other FAQs

    ... NICHD Research Information Clinical Trials Resources and Publications Pelvic Pain: Other FAQs Skip sharing on social media links ... more than one reason for my pain? Can pelvic pain affect my ability to become pregnant? Can alternative ...

  8. Breastfeeding FAQs: Solids and Supplementing

    ... necessary until he or she gets used to bottle feeding. If your baby has a hard time adjusting ... Positions Feeding Your 4- to 7-Month-Old Feeding Your 8- to 12-Month-Old Breastfeeding FAQs: Your Eating and Drinking Habits Breastfeeding FAQs: Out and About Breastfeeding FAQs: Pumping ...

  9. Low Vision FAQs

    ... de los Ojos Cómo hablarle a su oculista Low Vision FAQs What is low vision? Low vision is a visual impairment, not ... person’s ability to perform everyday activities. What causes low vision? Low vision can result from a variety ...

  10. Modernising the CERN Admin e-guide

    DG-RPC-PA (section des processus administratifs)


    In just a few years, the CERN Admin e-guide has become the essential guide for CERN's administrative procedures, intended not just for administrative services but for all members of the personnel of CERN. The guide is edited by the Administrative Process Section (DG-RPC-PA) and allows users to look up administrative procedures and forms relating to the application of the Staff Rules and Regulations easily in both French and English. Site visit statistics show that 5000 people on average consult the Admin e-guide each month. The most consulted procedures are those relating to green licence plates, taxes, Swiss and French cards and leave. The site has just been moved over to Drupal, which will make it easier to update the information provided and will improve content management. This system change meant migrating 220 procedures and more than 500 frequently asked questions. The structure has been revised for clarity, but the principles that made the guide so successful have not changed, namely the e...

  11. MedlinePlus FAQ: Framing

    ... URL of this page: I'd like to link to MedlinePlus, ... as HealthDay. Our license agreements do not permit framing of their content from our site. For more ...

  12. Formula Feeding FAQs: Starting Solids and Milk

    ... Year-Old Formula Feeding FAQs: Starting Solids and Milk KidsHealth > For Parents > Formula Feeding FAQs: Starting Solids ... When can I start giving my baby cow's milk? Before their first birthday, babies still need the ...

  13. Pregnancy Precautions: FAQs on Pregnancy Hazards

    ... Old Feeding Your 1- to 2-Year-Old Pregnancy Precautions: FAQs KidsHealth > For Parents > Pregnancy Precautions: FAQs ... your sanity during these 40 weeks . The Top Pregnancy Hazards You'll need to be particularly mindful ...

  14. FAQ sull’accesso aperto

    Maria Chiara Pievatolo


    Full Text Available Contro l’informazione poco accurata che circola nei giornali e in rete, abbiamo composto delle FAQ sull’accesso aperto con le relative risposte. Per il momento le abbiamo lasciate generiche. Le renderemo specifiche, secondo la normativa italiana quando il legislatore riuscirà a...

  15. Launch of the new CERN Admin e-guide

    Laëtitia Pedroso


    The CERN Admin e-guide is a new guide to the Organization's administrative procedures, which has been drawn up for the benefit of members of the personnel and the various administrative services alike and replaces the old "Administrative Procedures Manual". All the different procedures currently available on separate department sites will henceforth be accessible at a single website.   Home page of the new CERN Admin e-guide. The goal of creating a compendium of CERN's administrative procedures, available at a single website and accessible with a simple click of the mouse, has now been realised.  "It had become difficult to know where to find the relevant up-to-date information on administrative procedures", says Yaël Grange-Lavigne of the HR-SPS-OP Section (Organisation and Procedures), coordinator of the working group that compiled the e-guide. The team, which comprised members of the HR Department, observers from other department...

  16. Hepatitis C FAQs for the Public

    ... of Viral Hepatitis Contact Us Quick Links to Hepatitis … A | B | C | D | E Viral Hepatitis Home ... Local Partners & Grantees Policy and Programs Resource Center Hepatitis C FAQs for the Public Recommend on Facebook ...

  17. Hepatitis B FAQs for the Public

    ... Professional Resources Patient Education Resources Quick Links to Hepatitis … A | B | C | D | E Viral Hepatitis Home ... Grantees Policy and Programs Resource Center Viral Hepatitis Hepatitis B FAQs for the Public Recommend on Facebook ...

  18. Total Petroleum Hydrocarbons (TPH): ToxFAQs

    ... state: This map displays locations where Total Petroleum Hydrocarbons (TPH) is known to be present. On This ... get more information? ToxFAQs TM for Total Petroleum Hydrocarbons (TPH) ( Hidrocarburos Totales de Petróleo (TPH) ) August 1999 ...

  19. Donation FAQs (Bone and Tissue Allografts)

    ... Us Home Site Map Company Links Newsroom Careers Donation FAQs Over 120,000 people need organ transplants ... MTF encourages you to learn the facts about donation, to make a personal choice and to discuss ...

  20. Toxocariasis (also known as Roundworm Infection) FAQs

    ... Tropical Diseases Laboratory Diagnostic Assistance [DPDx] Parasites Home Toxocariasis FAQs Recommend on Facebook Tweet Share Compartir On ... toxocariasis? How can you prevent toxocariasis? What is toxocariasis? Toxocariasis is an infection transmitted from animals to ...

  1. Introducción a phpMyAdmin, ejercicio


    El propósito del siguiente ejercicio es replicar, más o menos, la base de datos utilizada en los videos de introducción a phpMyAdmin y comprobar que eres capaz de generar una base de datos y unas cuantas tablas relacionadas entre sí. La solución la tienes al final de este documento pero, claro, mejor si lo intentas por ti mismo primero. Recurso para el MOOC "Introducción al Desarrollo Web", BDgite (GITE-11014-UA), departamento de Lenguajes y Sistemas Informáticos, Uni...

  2. Frequently Asked Questions (FAQ) about Extreme Heat

    ... Part 3 of 3) Hot Weather Tips Heat Stress in Older Adults FAQs Extreme Heat PSAs Related Links MMWR Bibliography CDC's Program Floods Flood Readiness Personal Hygiene After a Disaster Cleanup of Flood Water After a Flood Worker Safety Educational Materials Floods ...

  3. Improving Windows desktop security - the 'Non-Admin' Project

    NICE Team


    From 16 January 2006, Windows XP NICE installations (both new computers installed and old computers re-installed) will no longer grant administrative privileges by default to the main user or to the person responsible for the computer. Administrative privileges allow the user to perform administrative actions on the computer, such as installing new applications or changing system settings. Until now, these privileges have been enforced each time machines are rebooted, but this creates a risk of compromising the computer every time a code from an unknown source (e.g. e-mail attachments or web browsing) is executed. So that users can continue to install software and change system settings on their computers, a shortcut called 'NiceAdmin' in the Start | Programmes menu will offer a means of performing certain tasks requiring administrative privileges, but only on demand. Users with valid reasons to be a permanent administrator for their machine will still have this option. However, users wishing to benefit fr...

  4. Introducción a phpMyAdmin (3/4)

    Suárez Cueto, Armando


    Curso "Introducción al desarrollo web": inserción de datos, creación de una relación muchos a muchos (N:N), claves ajenas, integridad referencial, diseñador de phpMyAdmin. Más información:

  5. Salmonella: Dry Pet Foods and Pet Treats (FAQ)

    ... Literature Reviews Market Research Statistics Reference Guides Reports Salmonella: Dry Pet Foods and Pet Treats (FAQ) Originally ... 2008, there was a prolonged multistate outbreak of Salmonella enterica serotype Schwarzengrund infections in humans. A total ...

  6. Design and Implementation of FAQ Automatic Return System Based on Similarity Computation


    FAQ (frequently asked question) is widely used on the Internet, but most FAQ's asking and answering are not automatic. This paper introduces the design and implementation of a FAQ automatic return system based on semantic similarity computation, including computation model choosing, FAQ characters analyzing, FAQ data formal expressing, feature vector indexing, and weight computing and so on. According to FAQ features of sentence length short, two mapping,strong domain characteristics etc. Vector Space Model with special semantic process was selected in system, and corresponding algorithm of similarity computation was proposed too. Experiment shows that the system has a good performance for high frequent and common questions.

  7. Introducción a phpMyAdmin (2/4)

    Suárez Cueto, Armando


    Curso "Introducción al desarrollo web": phpMyAdmin, creación de tablas, tipos de datos, creación de índices, motores de MySQL (INNODB, MyISAM, MEMORY), inserción de datos, seguimiento de una tabla (historial), exportar una tabla (backup). Más información:

  8. MedlinePlus FAQ: Can you tell me how to cite MedlinePlus pages?

    ... Here: Home → FAQs → Question URL of this page: Question: Can you ... Aug 12; cited 2005 Aug 11]. Available from: Health Topic page Begin by citing ...

  9. Mastering phpMyAdmin 34 for Effective MySQL Management

    Delisle, Marc


    This is a step-by-step instructional guide to get you started easily with phpMyAdmin and teach you to manage and perform database functions on your database. You will first be introduced to the interface and then build basic tables and perform both simple and advanced functions on the created database. The book progresses gradually and you will follow it best by reading it sequentially. If you are a developer, system administrator, or web designer who wants to manage MySQL databases and tables efficiently, then this book is for you. This book assumes that you are already wellacquainted with My

  10. Introducción a phpMyAdmin (1/4)

    Suárez Cueto, Armando


    Curso "Introducción al desarrollo web": explicación del escenario de aprendizaje, repaso de los conceptos básicos de las bases de datos relacionales (clave primaria, clave ajena, relación), repaso del lenguaje de consulta y de manipulación SQL (select, insert, delete, update), presentación del interfaz y del área de trabajo de phpMyAdmin, creación de un usuario de prueba, privilegios (permisos) de los usuarios. Más información:

  11. Introducción a phpMyAdmin (parte 0 o resumen)

    Suárez Cueto, Armando


    Curso "Introducción al desarrollo web": este vídeo realiza una doble función, sirve como introducción al resto de vídeos, pero también sirve como resumen, por lo que se puede ver tanto al principio como al final. En este vídeo se resume: - Objetivo de los vídeos, introducción a phpMyAdmin. - Parte 1: conceptos generales de bases de datos, creación de usuarios y privilegios. - Parte 2: creación de tablas, tipos de datos, motores de almacenamiento, inserción de filas, exportación (estructura y ...

  12. Semi-Automatically Extracting FAQs to Improve Accessibility of Software Development Knowledge

    Henß, Stefan; Mezini, Mira


    Frequently asked questions (FAQs) are a popular way to document software development knowledge. As creating such documents is expensive, this paper presents an approach for automatically extracting FAQs from sources of software development discussion, such as mailing lists and Internet forums, by combining techniques of text mining and natural language processing. We apply the approach to popular mailing lists and carry out a survey among software developers to show that it is able to extract high-quality FAQs that may be further improved by experts.

  13. MedlinePlus FAQ: Will MedlinePlus work on my mobile device?

    ... mobile.html Question: Will MedlinePlus work on my mobile device? To use the sharing features on this page, ... Some video content might not play on your mobile device. See our FAQ on playing videos on phones ...

  14. A Focused Review of the Reengineering Literature: Expert Frequently Asked Questions (FAQs)


    at Pacific Bell. Planning Review (May/June):28-33. Mark Nissen 24 Ives, B., Jarvenpaa, S.L., and R.O. Mason. 1993. Global business drivers...aligning information technology to global business strategy. IBM Systems Journal 32, no. 1:143-161. JAVA. 1996. Java FAQ archives. Internet World

  15. A FAQ-Based e-Learning Environment to Support Japanese Language Learning

    Liu, Yuqin; Yin, Chengjiu; Ogata, Hiroaki; Qiao, Guojun; Yano, Yoneo


    In traditional classes, having many questions from learners is important because these questions indicate difficult points for learners and for teachers. This paper proposes a FAQ-based e-Learning environment to support Japanese language learning that focuses on learner questions. This knowledge sharing system enables learners to interact and…

  16. Xgrid admin guide

    Strauss, Charlie E M [Los Alamos National Laboratory


    Xgrid, with a capital-X is the name for Apple's grid computing system. With a lower case x, xgrid is the name of the command line utility that clients can use, among other ways, to submit jobs to a controller. An Xgrid divides into three logical components: Agent, Controller and Client. Client computers submit jobs (a set of tasks) they want run to a Controller computer. The Controller queues the Client jobs and distributes tasks to Agent computers. Agent computers run the tasks and report their output and status back to the controller where it is stored until deleted by the Client. The Clients can asynchronously query the controller about the status of a job and the results. Any OSX computer can be any of these. A single mac can be more than one: it's possible to be Agent, Controller and Client at the same time. There is one Controller per Grid. Clients can submit jobs to Controllers of different grids. Agents can work for more than one grid. Xgrid's setup has a pleasantly small palette of choices. The first two decisions to make are the kind of authentication & authorization to use and if a shared file system is needed. A shared file system that all the agents can access can be very beneficial for many computing problems, but it is not appropriate for every network.

  17. Stillbirth FAQ

    ... and keep track of your baby’s movements (kicks, twists, turns, swishes or rolls). This will help you ... a week, 8am - 6pm First Candle, 9 Newport Drive, Suite 200, Forest Hill, MD 21050M ©2016 First ...

  18. Sunscreens FAQs

    ... D I get? Using sunscreen may decrease your skin’s production of vitamin D. If you are concerned that you are ... or vitamin supplements. This approach gives you the vitamin D you need without increasing your risk for skin cancer. For more information on vitamin D and ...

  19. Caregiver FAQ

    ... cognitively and socially active and physically fit. My wife is now diagnosed with DLB after having had ... still low among generalists and other specialties. My wife sees a head of a clinical department at ...

  20. Vulvodynia FAQ

    ... therapy? Trigger point therapy is a form of massage therapy. A trigger point is a small area ... nearby areas. Trigger point therapy involves soft tissue massage to break up the trigger point and relax ...

  1. Restricted Airspace

    Federal Laboratory Consortium — Redstone Technical Test Center has restricted airspace up to 30,000 feet ASL. Airspace encompasses R-2104 (Redstone). Airspace is used extensively for airborne/UAV...

  2. 基于VSM和LDA模型的FAQ问答系统%FAQ Answering System Based on VSM and LDA Model

    郑诚; 刘娇丽; 项珑


    传统的搜索引擎返回的数据太过庞大,很多情况下用户不能快速地找到自己要的答案。在这种情况下,文中引入FAQ系统。 FAQ中如何找到最佳匹配答案,是文中的研究重点。改进了传统的VSM模型,使得它能更好地体现问题中词的权重。重点引入了LDA模型,并用计算机故障领域内的文档资料对它进行训练,得到主题-词的概率分布。通过主题-词中词的概率分布,计算词与词的相关度,提出通过词与词间相关度计算句子与句子间相似度的算法。对两个算法进行综合,得到最终的相似度算法。文中对FAQ进行整理,得到了FAQ问答系统的雏形。通过实验分析,说明相似度算法有很好的效果。%The data returned by the traditional search engine is too large,users cannot quickly find the answer they want sometimes. In this case,introduce FAQ system. How to find the best match in the FAQ system is the focus. An improved VSM model is presented in this pa-per. This new model is used in order to reflect the weight of the terms in question better. LDA,which was trained with documentation within the domain of computer malfunction generates a probability distribution of topic-term by which the relevance between words is calculated. Then the algorithm of calculating similarity between sentences by calculating relevance between words was presented. Com-bined with the above two algorithm,get the final similarity algorithm. FAQ is collected and rudiment of FAQ answering system is imple-mented in this paper. The algorithm used is proved well by the experiments.

  3. Synthesis of Key Points from the OSEP Early Childhood Transition FAQ (SPP/APR Indicators C-8, B-11 and B-12)

    Diefendorf, M.; Henson, J.; Lucas, A.; Whaley, K.


    This document is a synthesis of the key points provided in the Office of Special Education Programs (OSEP) Early Childhood Transition FAQs: SPP/APR indicators C-8 and B-12 released on December 1, 2009. It was developed to assist states with the implementation of effective transition policies and practices. The following is included: (1) Transition…

  4. Progeria 101/FAQ

    ... Progeria, but also may shed light on the phenomenon of aging and cardiovascular disease.” v “Recurrent de ... Statistics Is Progeria passed down from parent to child? HGPS is not usually passed down in families. ...

  5. Bed Bugs FAQs

    ... Bed bugs have been found in five-star hotels and resorts and their presence is not determined ... sleep. These areas include apartments, shelters, rooming houses, hotels, cruise ships, buses, trains, and dorm rooms. They ...

  6. Hepatitis A FAQs

    ... Professional Resources Patient Education Resources Quick Links to Hepatitis … A | B | C | D | E Viral Hepatitis Home ... Grantees Policy and Programs Resource Center Viral Hepatitis Hepatitis A Questions and Answers for the Public Recommend ...

  7. I-94 Automation FAQs

    Department of Homeland Security — In order to increase efficiency, reduce operating costs and streamline the admissions process, U.S. Customs and Border Protection has automated Form I-94 at air and...

  8. ToxFAQs

    ... hidrógeno y flúor Formaldehyde | Formaldehido Fuel Oils / Kerosene | Aceites combustibles G Gasoline, Automotive | Gasolina de automóvil Glutaraldehyde * ... Uranium * Other Languages... Used Mineral-based Crankcase Oil | Aceite Usado de Cárter V Vanadium * Other Languages... Vinyl ...

  9. Ovarian Cancer FAQ

    ... increased risk of breast cancer and ovarian cancer. CA 125: A substance in the blood that may increase in the presence of some cancerous tumors. Colonoscopy: An exam of the entire colon using a small, lighted instrument. Computed Tomography: A ...

  10. Abnormal Uterine Bleeding FAQ

    ... can have many causes. They include the following: • Pregnancy • Miscarriage • Ectopic pregnancy • Adenomyosis • Use of some birth control methods, such ... the uterus at the top of the vagina. Ectopic Pregnancy: A pregnancy in which the fertilized egg begins ...

  11. Zoonotic Hookworm FAQs

    ... my pet? Yes, but not directly. Puppies and kittens are especially likely to have hookworm infections. Animals ... dogs or cats have been (especially puppies or kittens). How can I prevent animal hookworm infection? Wearing ...

  12. Prostate Cancer FAQs

    ... of Prostate Cancer Annual Report & Financials Our Leadership Leadership Team Board Members A Legacy of Leadership Featured Take ... Partners Faces of Prostate Cancer Annual Report & Financials Leadership Team Board Members Featured A Legacy of Leadership Take ...

  13. 'Which Multiverse?': Some FAQ

    Dugic, M


    Recently, we pointed out the possible inconsistency in the very foundations of the Everett MWI (or a Multiverse) theory. Here, we place some emphasis on the very basic notions underlying our conclusion yet motivated by certain, recently raised clever observations in this regard.

  14. Cushing Syndrome: Other FAQs

    ... Kronenberg, H. M., Shlomo, M., Polonsky, K. S., Larsen P. R. (Eds.). Williams textbook of endocrinology (12th ed.). (chap. 15). Philadelphia, PA: Saunders Elsevier. [top] Abraham, M. R., & Smith, C. V. Adrenal disease and pregnancy. Retrieved April ...

  15. Photoshop Lightroom 4 FAQs

    Sholik, Stan


    Get the answers to 365 of the most commonly asked questions about Lightroom Photographers who are getting acquainted with Photoshop Lightroom and all its advantages for managing large quantities of images will find this handy book an indispensable resource. Veteran photographer Stan Sholik answers 365 of the most frequently asked questions about the new Lightroom 4 in an informative, practical format, making it easy to find what you're looking for and put the information to use. Sample photos illustrate questions and answers, and a quick-reference guide provides easy access to must-have inform

  16. Polycystic Ovary Syndrome FAQ

    ... are common signs and symptoms of polycystic ovary syndrome (PCOS)? • What causes PCOS? • What is insulin resistance? • What can high levels of androgens lead to? • What can irregular menstrual periods lead ...

  17. Elder Abuse FAQS

    ... limited to: bruises, black eyes, welts, lacerations, and rope marks; bone fractures, broken bones, and skull fractures; ... older. 25 Vulnerability-based (regardless of age) Minnesota law defines a vulnerable adult as any person 18 ...

  18. Onchocerciasis (River Blindness) FAQs

    ... 6 countries in the Americas (Mexico, Guatemala, Ecuador, Colombia, Venezuela, and Brazil), but transmission has now stopped ... infection is greater in adventure travelers, missionaries, and Peace Corps and other long-term volunteers who are ...

  19. Prosthetic Care FAQs

    ... satisfaction in improving the quality of life for amputees. The field began to expand in the late ... that a good treatment plan will often include multiple visits, so it is helpful to consider a ...

  20. Animal Drug Safety FAQs

    ... and controls used for the manufacturing, processing and packaging of the drug are adequate to preserve its ... have a complaints regarding veterinary standard of care issues? Complaints and questions about standard of care issues ...

  1. Premenstrual Syndrome (PMS) FAQ

    ... syndrome irritable bowel syndrome thyroid disease Depression and anxiety disorders are the most common conditions that overlap with PMS. About one half of women seeking treatment for PMS have one of these ...

  2. FAQ: Child Sexual Exploitation

    ... as feelings of betrayal, powerlessness, worthlessness and low self-esteem. It is impossible to calculate how many times a child's pornographic image may be possessed and distributed online. Each and ...

  3. Turner Syndrome: Other FAQs

    ... can cause certain learning challenges, including problems learning mathematics and with memory. 7 Most girls and women ... syndrome usually require care from a variety of specialists throughout their lives. Will she be able to ...

  4. Restrictions and Proportionality

    Werlauff, Erik


    The article discusses three central aspects of the freedoms under European Community law, namely 1) the prohibition against restrictions as an important extension of the prohibition against discrimination, 2) a prohibition against exit restrictions which is just as important as the prohibition...... against host country restrictions, but which is often not recognised to the same extent by national law, and 3) the importance of also identifying and recognising an exit restriction, so that it is possible to achieve the required test of appropriateness and proportionality in relation to the rule...

  5. Salesforce CRM the definitive admin handbook

    Goodey, Paul


    A practical guide which will help to discover how to setup and configure the Salesforce CRM application. It offers solutions and practical examples on how to further improve and maintain its functionality with clear systematic instructions. Being highly organized and compact, this book contains detailed instructions with screenshots, diagrams, and tips that clearly describe how you can administer and configure complex Salesforce CRM functionality with absolute ease.This book is for administrators who want to develop and strengthen their Salesforce CRM skills in the areas of configuration and s

  6. Geographic Names Information System (GNIS) Admin Features

    Department of Homeland Security — The Geographic Names Information System (GNIS) is the Federal standard for geographic nomenclature. The U.S. Geological Survey developed the GNIS for the U.S. Board...

  7. MarFS-Requirements-Design-Configuration-Admin

    Kettering, Brett Michael [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Grider, Gary Alan [Los Alamos National Lab. (LANL), Los Alamos, NM (United States)


    This document will be organized into sections that are defined by the requirements for a file system that presents a near-POSIX (Portable Operating System Interface) interface to the user, but whose data is stored in whatever form is most efficient for the type of data being stored. After defining the requirement the design for meeting the requirement will be explained. Finally there will be sections on configuring and administering this file system. More and more, data dominates the computing world. There is a “sea” of data out there in many different formats that needs to be managed and used. “Mar” means “sea” in Spanish. Thus, this product is dubbed MarFS, a file system for a sea of data.

  8. Late gestational nutrient restriction

    Tygesen, Malin Plumhoff; Nielsen, Mette Olaf; Nørgaard, Peder;


    We investigated the effect of 50% nutrient restriction during the last 6 weeks of gestation on twin-pregnant ewes' plasma glucose, non-esterified fatty acid, ß-hydroxybutyrate, insulin, IGF-1 and leptin concentrations and the effects on lamb birth weight and ewes' lactation performance. Plasma...... metabolite and hormone concentrations in restricted ewes suggest that maternal tissues were being mobilised. Despite the ewes' adaptations their lambs weighed significantly less at birth. Furthermore, colostrum and milk yields were markedly reduced up until the latest measurement at 3 weeks post partum...

  9. Calorie restriction and stroke

    Manzanero Silvia


    Full Text Available Abstract Stroke, a major cause of disability and mortality in the elderly, occurs when a cerebral blood vessel is occluded or ruptured, resulting in ischemic damage and death of brain cells. The injury mechanism involves metabolic and oxidative stress, excitotoxicity, apoptosis and inflammatory processes, including activation of glial cells and infiltration of leukocytes. In animal models, dietary energy restriction, by daily calorie reduction (CR or intermittent fasting (IF, extends lifespan and decreases the development of age-related diseases. Dietary energy restriction may also benefit neurons, as suggested by experimental evidence showing that CR and IF protect neurons against degeneration in animal models. Recent findings by our group and others suggest the possibility that dietary energy restriction may protect against stroke induced brain injury, in part by inducing the expression of neurotrophic factors, such as brain-derived neurotrophic factor (BDNF and basic fibroblast growth factor (bFGF; protein chaperones, including heat shock protein 70 (Hsp70 and glucose regulated protein 78 (GRP78; antioxidant enzymes, such as superoxide dismutases (SOD and heme oxygenase-1 (HO-1, silent information regulator T1 (SIRT1, uncoupling proteins and anti-inflammatory cytokines. This article discusses the protective mechanisms activated by dietary energy restriction in ischemic stroke.

  10. Training Restricted Boltzmann Machines

    Fischer, Asja

    Restricted Boltzmann machines (RBMs) are probabilistic graphical models that can also be interpreted as stochastic neural networks. Training RBMs is known to be challenging. Computing the likelihood of the model parameters or its gradient is in general computationally intensive. Thus, training...

  11. Bilinear Fourier restriction theorems

    Demeter, Ciprian


    We provide a general scheme for proving $L^p$ estimates for certain bilinear Fourier restrictions outside the locally $L^2$ setting. As an application, we show how such estimates follow for the lacunary polygon. In contrast with prior approaches, our argument avoids any use of the Rubio de Francia Littlewood--Paley inequality.

  12. Improved VSM Algorithm and Its Application in FAQ%改进的VSM算法及其在FAQ中的应用

    郑诚; 李清; 刘福君


    现有的句子相似度算法的准确率较低.为此,提出一种改进的向量空间模型算法.在传统的向量空间模型中添加语义信息和句法信息,将其运用到句子相似度计算中,设计实现金融领域的FAQ自动问答系统,通过改进算法在FAQ中进行句子相似度计算,获取用户问题的答案.实验结果证明,该算法具有较高的准确率.%The accuracy of the existing sentence similarity algorithm needs to be improved, so this paper improves Vector Space Model(VSM) algorithm, adds some syntactic information and semantic information in the traditional VSM for computing sentence similarity. Meanwhile, it designs and realizes a financial Frequently Asked Question(FAQ) question answering system. The system computes sentence similarity by the improved VSM algorithm and returns the answer of users' question. Experimental result shows that this algorithm has higher accuracy in computing sentence similarity.

  13. Restricted and quasi-toral restricted Lie-Rinehart algebras

    Sun Bing


    Full Text Available In this paper, we introduce the definition of restrictable Lie-Rinehart algebras, the concept of restrictability is by far more tractable than that of a restricted Lie-Rinehart algebra. Moreover, we obtain some properties of p-mappings and restrictable Lie-Rinehart algebras. Finally, we give some sufficient conditions for the commutativity of quasi-toral restricted Lie-Rinehart algebras and study how a quasi-toral restricted Lie-Rinehart algebra with zero center and of minimal dimension should be.

  14. Restriction of Helmholtz Model

    V.M. Polunin


    Full Text Available The results of the experimental studies of physical mechanisms of energy dissipation in the oscillating system in which air cavity held by the forces of magnetic levitation is used as the elastic element, and magnetic fluid prepared on the basis of dispersing media with different viscosity level is used as the inertial element are considered in the article. Based on the obtained results the conclusion on the restriction of the applicability of Helmholtz equation, caused by boundary effects is made.

  15. License restrictions at Barnwell

    Autry, V.R. [S.C. Dept. of Health and Environmental Control, Columbia, SC (United States). Bureau of Radiological Health


    The State of South Carolina was delegated the authority by the US Nuclear Regulatory Commission to regulate the receipt, possession, use and disposal of radioactive material as an Agreement State. Since 1970, the state has been the principal regulatory authority for the Barnwell Low-Level Waste Disposal Facility operated by Chem-Nuclear Systems, Inc. The radioactive material license issued authorizing the receipt and disposal of low-level waste contains numerous restrictions to ensure environmental protection and compliance with shallow land disposal performance criteria. Low-level waste has evolved from minimally contaminated items to complex waste streams containing high concentrations of radionuclides and processing chemicals which necessitated these restrictions. Additionally, some waste with their specific radionuclides and concentration levels, many classified as low-level radioactive waste, are not appropriate for shallow land disposal unless additional precautions are taken. This paper will represent a number of these restrictions, the rationale for them, and how they are being dealt with at the Barnwell disposal facility.

  16. 急诊输液过程中的常见问题与防范措施%FAQS precautions emergency infusion process



    Objective:FAQS emergency infusion process ,careful analysis ,and proposed the corresponding preventive measures .Methods:For the emergency infusion room nurses technical problems ,the infusion of environmental issues ,health education issues ,the process of service delivery and quality of sercice issues taken care measures .Results :the emergency infusion significantly improve the quality of care through the implementation of appropriate care measures ,to improve the nurse-patient relationship ,improve patient satisfaction ,nurse -patient disputes and care greatly reduce complaints ,and to enhance the reputation of the hospital and the nurse's own values .Conclusion:improve the emergency infusion care quality is the key to improve patient satisfaction and reduce nurse-patient disputes .%目的:对急诊输液过程中出现的常见问题认真分析 ,提出相应的防范措施.方法 :针对急诊输液室护理人员技术问题、输液环境问题、健康宣教问题、服务流程问题及服务质量问题采取相应的护理措施.结果 :通过实施相应的护理措施后急诊输液护理质量明显提高 ,改善了护患关系 ,提高了患者满意度 ,护患纠纷和护理投诉大大减少 ,提升了医院的声誉和护士的自身价值.结论 :提高急诊输液护理质量是提高患者满意度和减少护患纠纷的关键所在.

  17. Very strict selectional restrictions

    Laporte, Eric; Dias, Maria Carmelita P


    We discuss the characteristics and behaviour of two parallel classes of verbs in two Romance languages, French and Portuguese. Examples of these verbs are Port. abater [gado] and Fr. abattre [b\\'etail], both meaning "slaughter [cattle]". In both languages, the definition of the class of verbs includes several features: - They have only one essential complement, which is a direct object. - The nominal distribution of the complement is very limited, i.e., few nouns can be selected as head nouns of the complement. However, this selection is not restricted to a single noun, as would be the case for verbal idioms such as Fr. monter la garde "mount guard". - We excluded from the class constructions which are reductions of more complex constructions, e.g. Port. afinar [instrumento] com "tune [instrument] with".

  18. Property Rights, Restrictions and Responsibilities

    Enemark, Stig

    Land Administration Systems are the basis for conceptualizing rights, restrictions and responsibilities related to people, policies and places. Property rights are normally concerned with ownership and tenure whereas restrictions usually control use and activities on land. Responsibilities relate...... more to a social, ethical commitment or attitude to environmental sustainability and good husbandry. This paper provides an overall understanding of the concept of land administration systems for dealing with rights, restrictions and responsibilities in future spatially enabled government. Finally...

  19. Klinefelter Syndrome (KS): Other FAQs

    ... them to stay focused [top] Michael, J. (2008). Endodontic treatment in three taurodontic teeth associated with 48, ... in men with Klinefelter syndrome: A cohort study. Journal of the National Cancer Institute , 97 (16),1204- ...

  20. Scabies: Frequently Asked Questions (FAQs)

    ... tip of a needle or by obtaining skin scraping to examine under a microscope for mites, eggs, ... of scabies should be confirmed by a skin scraping that includes observing the mite, eggs, or mite ...

  1. FAQs on leg ulcer care.

    Anderson, Irene; King, Brenda; Knight, Susan; Keynes, Milton

    In a webchat on leg ulcer management issues, hosted by Nursing Times, participants raised three key areas of care: the role of healthcare assistants in compression bandaging; reporting and investigating damage caused by compression therapy; and recommendations for dressings to be used under compression. This article discusses each of these in turn.

  2. Breastfeeding FAQs: Solids and Supplementing

    ... has gotten used to and is good at breastfeeding before you introduce a bottle. Lactation professionals recommend waiting until a baby is about 3 weeks old before offering artificial nipples of any kind (including pacifiers). continue If ...

  3. Remarks on restricted Nevanlinna transforms

    Jankowski, Lech


    The Nevanlinna transform K(z), of a measure and a real constant, plays an important role in the complex analysis and more recently in the free probability theory (boolean convolution). It is shown that its restriction k(it) (the restricted Nevanlinna transform) to the imaginary axis can be expressed as the Laplace transform of the Fourier transform (characteristic function) of the corresponding measure. Finally, a relation between the Voiculescu and the boolean convolution is indicated.

  4. Molecular motion in restricted geometries

    Siddharth Gautam; S Mitra; R Mukhopadhyay


    Molecular dynamics in restricted geometries is known to exhibit anomalous behaviour. Diffusion, translational or rotational, of molecules is altered significantly on confinement in restricted geometries. Quasielastic neutron scattering (QENS) offers a unique possibility of studying molecular motion in such systems. Both time scales involved in the motion and the geometry of motion can be studied using QENS. Molecular dynamics (MD) simulation not only provides insight into the details of the different types of motion possible but also does not suffer limitations of the experimental set-up. Here we report the effect of confinement on molecular dynamics in various restricted geometries as studied by QENS and MD simulations: An example where the QENS technique provided direct evidence of phase transition associated with change in the dynamical behaviour of the molecules is also discussed.

  5. Legal restrictions and Investment Growth

    Lensink, B.W.; Scholtens, B.


    We analyze the impact of legal restrictions on investment growth at the firm level. With the help of a unique firm-level survey database, we analyze whether firm investments are related to the efficiency and quality of the judiciary. Furthermore, we analyze whether the investment behavior of large a

  6. Legal restrictions and investment growth

    Lensink, B.W.; Scholtens, B.


    We analyze the impact of legal restrictions on investment growth at the firm level. With the help of a unique firm-level survey database, we analyze whether firm investments are related to the efficiency and quality of the judiciary, Furthermore, we analyze whether the investment behavior of large a

  7. Restrictive dermopathy and fetal behaviour

    Mulder, EJH; Beemer, FA; Stoutenbeek, P


    We report three siblings from consecutive pregnancies affected with restrictive dermopathy (RD). During the second pregnancy, fetal behavioural development and growth were studied extensively using ultrasound at 1-4 week intervals. Dramatic and sudden changes occurred in fetal body movements and gro

  8. Restricted Morgan’s problem

    陈树中; 曹立


    A new list of regular feedback invariant integers called right independent orders is introduced.That the restricted Morgan’s problem is equivalent to a kind of nonlinear algebraic equations is proved and the condition that the nonlinear algebraic equations degenerate into linear algebraic equations is given.

  9. 30 CFR 56.11008 - Restricted clearance.


    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Restricted clearance. 56.11008 Section 56.11008 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND NONMETAL MINE... Restricted clearance. Where restricted clearance creates a hazard to persons, the restricted clearance...

  10. 30 CFR 57.11008 - Restricted clearance.


    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Restricted clearance. 57.11008 Section 57.11008... Escapeways Travelways-Surface and Underground § 57.11008 Restricted clearance. Where restricted clearance creates a hazard to persons, the restricted clearance shall be conspicuously marked....

  11. Electromagnetic Fields Restrictions and Approximation

    Katsenelenbaum, Boris Z


    The fields scattered by metallic bodies or radiated by some types of antennas are created by the surfaces currents and therefore they are subject to some restrictions. The book is the first one where the properties of these fields are investigated in details. The properties have the important significance for the antenna synthesis, body shape reconstruction and other diffraction problems. The material of the book lies in the meetingpoint of the antenna theory, highfrequency electrodynamics and inverse scattering problems. The author is an internationally renowned investigator in the field of e

  12. Avoidant/Restrictive Food Intake Disorder

    ... for the Professional Version Eating Disorders Definition of Eating Disorders Anorexia Nervosa Avoidant/Restrictive Food Intake Disorder Binge Eating ... about what they eat. Eating Disorders Definition of Eating Disorders Anorexia Nervosa Avoidant/Restrictive Food Intake Disorder Binge Eating ...

  13. MySQL Admin Cookbook LITE Replication and Indexing

    Schneller, Daniel


    This cookbook presents solutions to problems in the form of recipes. Each recipe provides the reader with easy step-by-step descriptions of the actions necessary to accomplish a specific task. Example values and code samples are used throughout the recipes, which makes adaptation for individual needs easy. This book is for ambitious MySQL users as well as professional data center database administrators. Beginners as well as experienced administrators will benefit from this cookbook and get fresh ideas to improve their MySQL environments. Detailed background information will enable them to wid

  14. Creating Simple Admin Tools Using Info*Engine and Java

    Jones, Corey; Kapatos, Dennis; Skradski, Cory; Felkins, J. D.


    PTC has provided a simple way to dynamically interact with Windchill using Info*Engine. This presentation will describe how to create a simple Info*Engine Tasks capable of saving Windchill 10.0 administration of tedious work.

  15. Operationalizing Cyberspace for Today’s Combat Air Force


    top-cyber-security-risks/#trends ( accesed 12 March 2010). 24 Ibid. 25 Ibid. 26 Ibid. 27 Dr. Daniel T. Kuehl, (Professor, National Defense...trends ( accesed 12 March 2010). SysAdmin, Audit, Network, Security Institute. “Intrusion Detection FAQ: What was the Melissa virus and what can we

  16. 7 CFR 982.14 - Restricted hazelnuts.


    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Restricted hazelnuts. 982.14 Section 982.14... Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE HAZELNUTS GROWN IN OREGON AND WASHINGTON Order Regulating Handling Definitions § 982.14 Restricted hazelnuts. Restricted hazelnuts...

  17. Problem-Solving Test: Restriction Endonuclease Mapping

    Szeberenyi, Jozsef


    The term "restriction endonuclease mapping" covers a number of related techniques used to identify specific restriction enzyme recognition sites on small DNA molecules. A method for restriction endonuclease mapping of a 1,000-basepair (bp)-long DNA molecule is described in the fictitious experiment of this test. The most important fact needed to…

  18. Restriction Enzyme Mapping: A Simple Student Practical.

    Higgins, Stephen J.; And Others


    An experiment that uses the recombinant plasmid pX1108 to illustrate restriction mapping is described. The experiment involves three restriction enzymes and employs single and double restriction enzyme digestions. A list of needed materials, procedures, safety precautions, results, and discussion are included. (KR)

  19. Restrictive Imputation of Incomplete Survey Data

    Vink, G.


    This dissertation focuses on finding plausible imputations when there is some restriction posed on the imputation model. In these restrictive situations, current imputation methodology does not lead to satisfactory imputations. The restrictions, and the resulting missing data problems are real-life

  20. 29 CFR 18.56 - Restricted access.


    ... 29 Labor 1 2010-07-01 2010-07-01 true Restricted access. 18.56 Section 18.56 Labor Office of the... ADMINISTRATIVE LAW JUDGES General § 18.56 Restricted access. On his or her own motion, or on the motion of any party, the administrative law judge may direct that there be a restricted access portion of the...

  1. 28 CFR 68.51 - Restricted access.


    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Restricted access. 68.51 Section 68.51... ALIENS, UNFAIR IMMIGRATION-RELATED EMPLOYMENT PRACTICES, AND DOCUMENT FRAUD § 68.51 Restricted access. On... be a restricted access portion of the record to contain any material in the record to which...

  2. 47 CFR 1.1208 - Restricted proceedings.


    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Restricted proceedings. 1.1208 Section 1.1208... Restricted Proceedings § 1.1208 Restricted proceedings. Unless otherwise provided by the Commission or its... in all proceedings not listed as exempt in § 1.1204(b) or permit-but-disclose in § 1.1206(a) of...

  3. Querying Schemas With Access Restrictions

    Benedikt, Michael; Ley, Clemens


    We study verification of systems whose transitions consist of accesses to a Web-based data-source. An access is a lookup on a relation within a relational database, fixing values for a set of positions in the relation. For example, a transition can represent access to a Web form, where the user is restricted to filling in values for a particular set of fields. We look at verifying properties of a schema describing the possible accesses of such a system. We present a language where one can describe the properties of an access path, and also specify additional restrictions on accesses that are enforced by the schema. Our main property language, AccLTL, is based on a first-order extension of linear-time temporal logic, interpreting access paths as sequences of relational structures. We also present a lower-level automaton model, Aautomata, which AccLTL specifications can compile into. We show that AccLTL and A-automata can express static analysis problems related to "querying with limited access patterns" that h...

  4. A Traffic Restriction Scheme for Enhancing Carpooling

    Dong Ding


    Full Text Available For the purpose of alleviating traffic congestion, this paper proposes a scheme to encourage travelers to carpool by traffic restriction. By a variational inequity we describe travelers’ mode (solo driving and carpooling and route choice under user equilibrium principle in the context of fixed demand and detect the performance of a simple network with various restriction links, restriction proportions, and carpooling costs. Then the optimal traffic restriction scheme aiming at minimal total travel cost is designed through a bilevel program and applied to a Sioux Fall network example with genetic algorithm. According to various requirements, optimal restriction regions and proportions for restricted automobiles are captured. From the results it is found that traffic restriction scheme is possible to enhance carpooling and alleviate congestion. However, higher carpooling demand is not always helpful to the whole network. The topology of network, OD demand, and carpooling cost are included in the factors influencing the performance of the traffic system.

  5. Gentile statistics and restricted partitions

    C S Srivatsan; M V N Murthy; R K Bhaduri


    In a recent paper (Tran et al, Ann. Phys. 311, 204 (2004)), some asymptotic number theoretical results on the partitioning of an integer were derived exploiting its connection to the quantum density of states of a many-particle system. We generalise these results to obtain an asymptotic formula for the restricted or coloured partitions $p_{k}^{s} (n)$, which is the number of partitions of an integer into the summand of th powers of integers such that each power of a given integer may occur utmost times. While the method is not rigorous, it reproduces the well-known asymptotic results for = 1 apart from yielding more general results for arbitrary values of .

  6. Neurodevelopment after fetal growth restriction.

    Baschat, Ahmet A


    Fetal growth restriction (FGR) can emerge as a complication of placental dysfunction and increases the risk for neurodevelopmental delay. Marked elevations of umbilical artery (UA) Doppler resistance that set the stage for cardiovascular and biophysical deterioration with subsequent preterm birth characterize early-onset FGR. Minimal, or absent UA Doppler abnormalities and isolated cerebral Doppler changes with subtle deterioration and a high risk for unanticipated term stillbirth are characteristic for late-onset FGR. Nutritional deficiency manifested in lagging head growth is the most powerful predictor of developmental delay in all forms of FGR. Extremes of blood flow resistance and cardiovascular deterioration, prematurity and intracranial hemorrhage increase the risks for psychomotor delay and cerebral palsy. In late-onset FGR, regional cerebral vascular redistribution correlates with abnormal behavioral domains. Irrespective of the phenotype of FGR, prenatal tests that provide precise and independent stratification of risks for adverse neurodevelopment have yet to be determined.


    Petar Petrov


    For given data (ti,yi), I= 0,1,…,n,0 = t0 <t1 <…<tn = 1we study constrained interpolation problem of Favard type inf{‖f"‖∞|f∈W2∞[0,1],f(ti)=yi,i=0,…,n,l(f;[0,1])≤l0}, wherel(f";[0,1])=∫1 0 / 1+f'2(x)dx is the arc length off in [0,1]. We prove the existence of a solution f* of the above problem, that is a quadratic spline with a second derivative f"* , which coincides with one of the constants - ‖f"*‖∞,0,‖f"*‖∞ between every two consecutive knots. Thus, we extend a result ofKarlin concerning Favard problem, to the case of restricted length interpolation.

  8. Stillbirth and fetal growth restriction.

    Bukowski, Radek


    The association between stillbirth and fetal growth restriction is strong and supported by a large body of evidence and clinically employed for the stillbirth prediction. However, although assessment of fetal growth is a basis of clinical practice, it is not trivial. Essentially, fetal growth is a result of the genetic growth potential of the fetus and placental function. The growth potential is the driving force of fetal growth, whereas the placenta as the sole source of nutrients and oxygen might become the rate limiting element of fetal growth if its function is impaired. Thus, placental dysfunction may prevent the fetus from reaching its full genetically determined growth potential. In this sense fetal growth and its aberration provides an insight into placental function. Fetal growth is a proxy for the test of the effectiveness of placenta, whose function is otherwise obscured during pregnancy.

  9. An Infinite Restricted Boltzmann Machine.

    Côté, Marc-Alexandre; Larochelle, Hugo


    We present a mathematical construction for the restricted Boltzmann machine (RBM) that does not require specifying the number of hidden units. In fact, the hidden layer size is adaptive and can grow during training. This is obtained by first extending the RBM to be sensitive to the ordering of its hidden units. Then, with a carefully chosen definition of the energy function, we show that the limit of infinitely many hidden units is well defined. As with RBM, approximate maximum likelihood training can be performed, resulting in an algorithm that naturally and adaptively adds trained hidden units during learning. We empirically study the behavior of this infinite RBM, showing that its performance is competitive to that of the RBM, while not requiring the tuning of a hidden layer size.

  10. 10 CFR 1045.16 - Criteria for evaluation of restricted data and formerly restricted data information.


    ... § 1045.16 Criteria for evaluation of restricted data and formerly restricted data information. (a) The... 10 Energy 4 2010-01-01 2010-01-01 false Criteria for evaluation of restricted data and formerly restricted data information. 1045.16 Section 1045.16 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS)...

  11. Restricted Interval Valued Neutrosophic Sets and Restricted Interval Valued Neutrosophic Topological Spaces

    Anjan Mukherjee


    Full Text Available In this paper we introduce the concept of restricted interval valued neutrosophic sets (RIVNS in short. Some basic operations and properties of RIVNS are discussed. The concept of restricted interval valued neutrosophic topology is also introduced together with restricted interval valued neutrosophic finer and restricted interval valued neutrosophic coarser topology. We also define restricted interval valued neutrosophic interior and closer of a restricted interval valued neutrosophic set. Some theorems and examples are cites. Restricted interval valued neutrosophic subspace topology is also studied.

  12. FAQ and Advices in Parent-child Education for 3-6 Years Old Children in China%我国3-6岁幼儿亲子教育中的常见问题及对策



    自20世纪末起,亲子教育的研究开始蓬勃发展起来。人们也开始意识到3-6岁是孩子成长的一个关键期。如何把握这个关键期,与幼儿建立起融洽的亲子关系,并选择恰当的方式方法对其进行教育,以促进他的身心的健康发展,是每个家长关心的问题。文章试图从教育态度和教育方法两个方面分析当今3-6岁幼儿亲子教育中的常见问题,并尝试着提出可行性建议,旨在能切实帮助家长解决亲子教育问题,促进幼儿的健康成长。%Since the end of 20th century, the study of parent-child education has been developed vigor-ously. Many people began to realize that 3 to 6 years old is children’s critical growth period. The way to grasp the critical period,establish harmonious parent-child relation,and select the proper education method to promote the sound development both in children's mind and body are every parent's concerns. This paper tries to analyze the FAQ (Frequently Asked Questions)in parent-child education for 3-6-year-old children, aiming at finding and proposing some effective advices so as to improve children's healthy growth.

  13. Measuring Regulatory Restrictions in Logistics Services

    Claire HOLLWEG; Marn-Heong WONG


    This study measures the extent of restrictions on trade in logistics services in the ASEAN+6 economies by constructing a logistics regulatory restrictiveness index for each economy that quantifies the extent of government regulations faced by logistics service providers. This is the first study of its kind to construct a regulatory index of the entire logistics sector, which includes the main modes of international transport and customs restrictions. The indices show that large differences ex...

  14. Restricted Interests and Teacher Presentation of Items

    Stocco, Corey S.; Thompson, Rachel H.; Rodriguez, Nicole M.


    Restricted and repetitive behavior (RRB) is more pervasive, prevalent, frequent, and severe in individuals with autism spectrum disorders (ASDs) than in their typical peers. One subtype of RRB is restricted interests in items or activities, which is evident in the manner in which individuals engage with items (e.g., repetitious wheel spinning),…

  15. 33 CFR 203.46 - Restrictions.


    ... Flood Control Works Damaged by Flood or Coastal Storm: The Corps Rehabilitation and Inspection Program § 203.46 Restrictions. (a) Restrictions to flood control works. Flood control works are designed and...) Non-flood related rehabilitation. Rehabilitation of flood control structures damaged by...

  16. 7 CFR 400.407 - Restricted access.


    ... 7 Agriculture 6 2010-01-01 2010-01-01 false Restricted access. 400.407 Section 400.407 Agriculture... Social Security Account Numbers and Employer Identification Numbers § 400.407 Restricted access. The Manager, other officer, or employee of FCIC or an authorized person may have access to the SSNs and...

  17. Restriction beyond the restriction point: mitogen requirement for G2 passage

    te Riele Hein


    Full Text Available Abstract Cell proliferation is dependent on mitogenic signalling. When absent, normal cells cannot pass the G1 restriction point, resulting in cell cycle arrest. Passage through the G1 restriction point involves inactivation of the retinoblastoma protein family. Consequently, loss of the retinoblastoma protein family leads to loss of the G1 restriction point. Recent work in our lab has revealed that cells possess yet another mechanism that restricts proliferation in the absence of mitogens: arrest in the G2 phase of the cell cycle. Here, we discuss the similarities and differences between these restriction points and the roles of cyclin-dependent kinase inhibitors (CKIs herein.

  18. Restriction enzyme mining for SNPs in genomes.

    Chuang, Li-Yeh; Yang, Cheng-Hong; Tsui, Ke-Hung; Cheng, Yu-Huei; Chang, Phei-Lang; Wen, Cheng-Hao; Chang, Hsueh-Wei


    Many different single nucleotide polymorphisms (SNPs) genotyping methods have been developed recently. However, most of them are expensive. Using restriction enzymes for SNP genotyping is a cost-effective method. However, restriction enzyme mining for SNPs in a genome sequence is still challenging for researchers who do not have a background in genomics and bioinformatics. In this review, the basic bioinformatics tools used for restriction enzyme mining for SNP genotyping are summarized and described. The objectives of this paper include: i) the introduction of SNPs, genotyping and PCR-restriction fragment length polymorphism (RFLP); ii) a review of components for genotyping software, including tools for primer design only or restriction enzyme mining only; iii) a review of software providing the flanking sequence for primer design; iv) recent advances in PCR-RFLP tools and natural and mutagenic PCR-RFLP; v) highlighting the strategy for restriction enzyme mining for SNP genotyping; vi) a discussion of potential problems for multiple PCR-RFLP. The different implications for restriction enzymes on sense and antisense strands are also discussed. Our PCR-RFLP freeware, SNP-RFLPing, is included in this review to illustrate many characteristics of PCR-RFLP software design. Future developments will include further sophistication of PCR-RFLP software in order to provide better visualization and a more interactive environment for SNP genotyping and to integrate the software with other tools used in association studies.

  19. Urban water restrictions: Attitudes and avoidance

    Cooper, Bethany; Burton, Michael; Crase, Lin


    In most urban cities across Australia, water restrictions remain the dominant policy mechanism to restrict urban water consumption. The extensive adoption of water restrictions as a means to limit demand, over several years, means that Australian urban water prices have consistently not reflected the opportunity cost of water. Given the generally strong political support for water restrictions and the likelihood that they will persist for some time, there is value in understanding households' attitudes in this context. More specifically, identifying the welfare gains associated with avoiding urban water restrictions entirely would be a nontrivial contribution to our knowledge and offer insights into the benefits of alternative policy responses. This paper describes the results from a contingent valuation study that investigates consumers' willingness to pay to avoid urban water restrictions. Importantly, the research also investigates the influence of cognitive and exogenous dimensions on the utility gain associated with avoiding water restrictions. The results provide insights into the impact of the current policy mechanism on economic welfare.

  20. The Frattini Subalgebra of Restricted Lie Superalgebras

    Liang Yun CHEN; Dao Ji MENG; Yong Zheng ZHANG


    In the present paper, we study the Frattini subalgebra of a restricted Lie superalgebra (L, [p]). We show first that if L = A1 (⊙) A2 (⊙) … (⊙) An, then φp (L) = φp (A1) + φp (A2) +… +φp (An),where each Ai is a p-ideal of L. We then obtain two results: F(L) = φ(L) = J(L) = L(1) if and only if L is nilpotent; Fp(L) and F(L) are nilpotent ideals of L if L is solvable. In addition, necessary and sufficient conditions are found for φp-free restricted Lie superalgebras. Finally, we discuss the relationships of E-p-restricted Lie superalgebras and E-restricted Lie superalgebras.

  1. Restriction/modification polypeptides, polynucleotides, and methods

    Westpheling, Janet; Chung, DaeHwan; Huddleston, Jennifer; Farkas, Joel A


    The present invention relates to the discovery of a novel restriction/modification system in Caldicellulosiruptor bescii. The discovered restriction enzyme is a HaeIII-like restriction enzyme that possesses a thermophilic activity profile. The restriction/modification system also includes a methyltransferase, M.CbeI, that methylates at least one cytosine residue in the CbeI recognition sequence to m.sup.4C. Thus, the invention provides, in various aspects, isolated CbeI or M.CbeI polypeptides, or biologically active fragments thereof; isolated polynucleotides that encode the CbeI or M.CbeI polypeptides or biologically active fragments thereof, including expression vectors that include such polynucleotide sequences; methods of digesting DNA using a CbeI polypeptide; methods of treating a DNA molecule using a M.CbeI polypeptide; and methods of transforming a Caldicellulosiruptor cell.

  2. Restricted Coherent Risk Measures and Actuarial Solvency

    Christos E. Kountzakis


    Full Text Available We prove a general dual representation form for restricted coherent risk measures, and we apply it to a minimization problem of the required solvency capital for an insurance company.

  3. 7 CFR 982.50 - Restricted obligation.


    ... WASHINGTON Order Regulating Handling Control of Distribution § 982.50 Restricted obligation. (a) No handler... procedures as are necessary to facilitate the administration of this option among handlers. (d) Whenever...

  4. Date restricted queries in web search engines

    Lewandowski, Dirk


    Search engines usually offer a date restricted search on their advanced search pages. But determining the actual update of a web page is not without problems. We conduct a study testing date restricted queries on the search engines Google, Teoma and Yahoo!. We find that these searches fail to work properly in the examined engines. We discuss implications of this for further research and search engine development.

  5. Dietary restriction causing iodine-deficient goitre.

    Cheetham, Tim; Plumb, Emma; Callaghan, James; Jackson, Michael; Michaelis, Louise


    Iodine-deficient goitre was common in some parts of the UK prior to the introduction of salt iodisation. Many contemporary salt preparations do not contain much iodine, and there are renewed concerns about the iodine status of the population. We present a boy with severe allergy who developed goitre and significant thyroid dysfunction in association with an iodine-deficient 'food-restricted' diet. The case highlights the importance of a comprehensive nutritional assessment in all children on multiple food restrictions.

  6. Policy restrictions, democratic deficit and redistribution


    Restrictions to the range of policies available to governments are often recommended as a solution to coordination failures or time inconsistency problems. However, policy restrictions can have important drawbacks that have been generally ignored so far. When the hands of governments are tied, citizens have lower incentives to be informed on political matters and to participate in collective decision-making processes, since private returns from political information are lower. This mechanism ...

  7. Dietary restriction with and without caloric restriction for healthy aging [version 1; referees: 3 approved

    Changhan Lee


    Full Text Available Caloric restriction is the most effective and reproducible dietary intervention known to regulate aging and increase the healthy lifespan in various model organisms, ranging from the unicellular yeast to worms, flies, rodents, and primates. However, caloric restriction, which in most cases entails a 20–40% reduction of food consumption relative to normal intake, is a severe intervention that results in both beneficial and detrimental effects. Specific types of chronic, intermittent, or periodic dietary restrictions without chronic caloric restriction have instead the potential to provide a significant healthspan increase while minimizing adverse effects. Improved periodic or targeted dietary restriction regimens that uncouple the challenge of food deprivation from the beneficial effects will allow a safe intervention feasible for a major portion of the population. Here we focus on healthspan interventions that are not chronic or do not require calorie restriction.

  8. Dipylidium (Dog and Cat Flea Tapeworm) FAQs

    ... the most common kind of tapeworm dogs and cats get? The most common tapeworm of dogs and cats in the United States is called Dipylidium caninum . ... infected with a tapeworm larvae. A dog or cat may swallow a flea while self-grooming. Once ...

  9. Contraception and Birth Control: Other FAQs

    ... other than preventing pregnancy? Yes. Use of oral contraceptives can also reduce severe menstrual cramps, make menstrual bleeding lighter, and clear up acne. There is also evidence that use of the pill can reduce the risk of endometrial,ovarian, and colon cancer, reduce the ...

  10. Lyme Disease Frequently Asked Questions (FAQ)

    ... the following year. What is a surveillance case definition? Reporting of all nationally notifiable diseases, including Lyme ... conjunction with local health care systems, health departments, schools, and community events (farmers’ markets, trail runs, etc.). ...

  11. Breastfeeding FAQs: Sleep - Yours and Your Baby's

    ... School & Family Life First Aid & Safety Doctors & Hospitals Q&A Recipes En Español Teachers - Looking for Health ... I do? Newborns often fall asleep at the breast, especially after feeling satisfied from a good feeding. ( ...

  12. Adaptation funding and development assistance: some FAQs

    Ayers, Jessica; Huq, Saleemul


    It's becoming ever clearer that development and climate change are intertwined issues. Unsustainable development drives climate change; sustainable development can reduce vulnerability to it. Development issues can constrain capacity to adapt to climate change; climate impacts can be a barrier to development. So adaptation to climate impacts is increasingly seen as part of good development practice – and development to improve the lives and resource access of people facing climate challenges is viewed as a prerequisite for successful adaptation. But when it comes to adaptation funding, confusion and contention remain over the role development institutions play.

  13. FAQ: Insect Repellent Use and Safety

    ... Mosquito Surveillance Software Health Education Public Service Videos Insect Repellent Use & Safety Recommend on Facebook Tweet Share ... the repellent with you. Top of Page Can insect repellents be used on children? Yes. Most products ...

  14. FAQ: West Nile Virus and Dead Birds

    ... Education Public Service Videos West Nile Virus & Dead Birds Recommend on Facebook Tweet Share Compartir On This ... dead bird sightings to local authorities. How do birds get infected with West Nile virus? West Nile ...

  15. UML Semantics FAQ: Dynamic Behaviour and Concurrency

    Wieringa, Roel; Astesiano, Egidio; Reggio, Gianna; Le Guennec, Alain; Hussman, Heinrich; Berg, van den Klaas; Broek, van den Pim; Demeyer, Serge


    This paper reports the results of a workshop held at ECOOP'99. The workshop was set up to find answers to questions fundamental to the definition of a semantics for the Unified Modelling Language. Questions examined the meaning of the term semantics in the context of UML; approaches to defining the

  16. FAQ: Blood Donation and Organ Transplant

    ... Surveillance Software Health Education Public Service Videos Blood Donation & Organ Transplant Recommend on Facebook Tweet Share Compartir ... giving blood, you should tell your blood center. Donation centers try to ensure that donors who recently ...

  17. Pregnancy Precautions: FAQs on Pregnancy Hazards

    ... down or stop caffeine intake. Studies show that caffeine consumption of more than 200–300 milligrams a day ( ... What are the risks to my baby? High caffeine consumption has been linked to an increased risk of ...

  18. Breastfeeding FAQs: Sleep - Yours and Your Baby's

    ... sharing , is hazardous and increases the risk of sudden infant death syndrome (SIDS) . While bed-sharing isn't a good idea, room-sharing (keeping your little one close by) can help make ... Put a bassinet, play yard, or crib next to your bed. This lets you keep ...

  19. Frequently Asked Questions (FAQs) about Malaria

    ... disease maintains a vicious cycle of disease and poverty. Top of Page How People Get Malaria (Transmission) ... a list of all the places in the world where malaria transmission occurs and the malaria drugs ...

  20. Trichinellosis (also known as Trichinosis) FAQs

    ... meat and plant-eating) animals such as domestic pigs or wild boar. What are the signs and symptoms of ... Trichinella infection in animal populations, do not allow pigs or wild animals to eat uncooked meat, scraps, or carcasses ...

  1. Frequently Asked Questions (FAQ) about Plague

    ... Specific Hazards Bioterrorism A-Z Anthrax (Bacillus anthracis) Arenaviruses Treatment & Infection Control Specimen Submission & Lab Testing Education & ... hemorrhagic fevers (filoviruses [e.g., Ebola, Marburg] and arenaviruses [e.g., Lassa, Machupo]) Yersinia pestis (plague) Fact ...

  2. Lymphatic Filariasis: Frequently Asked Questions (FAQs)

    ... in the skin and lymph system. This causes hardening and thickening of the skin, which is called ... Carefully wash the swollen area with soap and water every day. Elevate and exercise the swollen arm ...

  3. Tracks FAQs: What is Modeled Air Data?


    In this podcast, CDC Tracking experts discuss modeled air data. Do you have a question for our Tracking experts? Please e-mail questions to  Created: 4/25/2011 by National Center for Environmental Health, Division of Environmental Hazards and Health Effects, Environmental Health Tracking Branch.   Date Released: 4/25/2011.

  4. FAQ: General Questions about West Nile Virus

    ... Public Service Videos General Questions About West Nile Virus Recommend on Facebook Tweet Share Compartir On this ... West Nile virus cases? What is West Nile virus? West Nile virus is an arthropod-borne virus ( ...

  5. Miles In Trail (MIT) Restrictions: A Perspective

    Kopardekar, Parimal; Green, Steven; Roherty, Tom; Aston, John


    Miles-in-trail restrictions are issued to meet the airport and/or airspace capacity. The purpose of this paper is to review the currently practiced miles-in-trail operations for traffic flow management at a typical en route Air Traffic Control Center. The paper describes roles and considerations of both traffic management coordinators and the controllers in planning, coordination, execution, and monitoring of miles-in-trail restrictions. The paper addresses the type of decisions that traffic management coordinators must make and the different information required to plan and monitor miles-in-trail restrictions. The implications of miles-in-trail restrictions on controller workload are also addressed. Using the Cleveland center as an example, the paper also identified some challenging traffic situations that required miles-in-trail restrictions on a regular basis. The paper is expected to benefit the research and development community as it provides the current challenges in traffic flow management and strengths and weakness of miles-in-trail operations.

  6. Newer antidiabetic drugs and calorie restriction mimicry

    Sanjay Kalra


    Full Text Available De-acceleration of aging and delayed development of age-related morbidity accompanies the restriction of calories (without malnutrition in laboratory mice, nematodes, yeast, fish, and dogs. Recent results from long-term longitudinal studies conducted on primates have suggested longevity benefits of a 30% restriction of calories in rhesus monkeys as well. Among calorie restricted rhesus monkeys one of the mechanisms for the improvement in lifespan was the reduction in the development of glucose intolerance and cardiovascular disease. Although there are no comparable human studies, it is likely that metabolic and longevity benefits will accompany a reduction in calories in humans as well. However, considering the difficulties in getting healthy adults to limit food intake science has focused on understanding the biochemical processes that accompany calorie restriction (CR to formulate drugs that would mimic the effects of CR without the need to actually restrict calories. Drugs in this emerging therapeutic field are called CR mimetics. Some of the currently used anti-diabetic agents may have some CR mimetic like effects. This review focuses on the CR mimetic properties of the currently available anti-diabetic agents.

  7. Ruminant models of prenatal growth restriction.

    Anthony, R V; Scheaffer, A N; Wright, C D; Regnault, T R H


    Intrauterine growth restriction (IUGR) is a significant health issue that not only affects infant mortality and morbidity, but may also predispose individuals to coronary heart disease, diabetes, hypertension and stroke as adults. The majority of IUGR pregnancies in humans are characterized by asymmetric fetal growth, resulting from inadequate nutrient transfer to the fetus. Furthermore, most of these pregnancies involve functional placental insufficiency, and may also show altered umbilical velocimetry. As the severity of IUGR increases, the fetus becomes increasingly hypoxic, hypoglycaemic and acidotic. In addition, placental transfer or utilization of some amino acids is known to be altered in IUGR pregnancies. Although a great deal has been learned from clinical studies of human IUGR, appropriate animal models are required to define completely the mechanisms involved in the development of IUGR. The pregnant sheep is a long-standing model for placental-fetal interactions, and fetal growth restriction can be induced in pregnant sheep by maternal nutrient restriction, maternal nutrient excess, administration of glucocorticoid, utero-placental embolization, carunclectomy and maternal hyperthermia. Although all of these sheep models are capable of inducing fetal growth restriction, the degree of restriction is variable. This review compares these sheep models of IUGR with the characteristics of human IUGR.

  8. Sight Restrictions in Maghrib Muslim Architecture

    Mustapha Ben Hamouche


    Full Text Available Sight in Islamic culture is subject to legal restrictions that aim at preserving moral consciousness in Muslim societies. These restrictions have a direct impact on architecture in traditional Muslim cities. Details such as placement of doors and windows, the use of balconies and rooftops, and building heights were shaped by legal reasoning based on sight restrictions. The present study aims at highlighting this legal reasoning system by analyzing legal opinions that were continuously advocated by jurists in response to daily practices, and the legal principles on which these opinions were based. This is expected to contribute in developing a new intellectual discourse on Muslim architecture that could go beyond the present design theories.

  9. 'Liberal' vs. 'restrictive' perioperative fluid therapy

    Bundgaard-Nielsen, M; Secher, N H; Kehlet, H


    found differences in the selected outcome parameters. CONCLUSION: Liberal vs. restrictive fixed-volume regimens are not well defined in the literature regarding the definition, methodology and results, and lack the use of or information on evidence-based standardized perioperative care-principles (fast......BACKGROUND: Several studies have assessed the effect of a 'liberal' vs. a 'restrictive' perioperative fluid regimen on post-operative outcome. The literature was reviewed in order to provide recommendations regarding perioperative fluid regimens. METHODS: A PubMed search identified randomized...... period. Also, information regarding perioperative care and type of anaesthesia was assessed. RESULTS: In the seven randomized studies identified, the range of the liberal intraoperative fluid regimen was from 2750 to 5388 ml compared with 998 to 2740 ml for the restrictive fluid regimen. The period...

  10. Epigenetic regulation of caloric restriction in aging

    Daniel Michael


    Full Text Available Abstract The molecular mechanisms of aging are the subject of much research and have facilitated potential interventions to delay aging and aging-related degenerative diseases in humans. The aging process is frequently affected by environmental factors, and caloric restriction is by far the most effective and established environmental manipulation for extending lifespan in various animal models. However, the precise mechanisms by which caloric restriction affects lifespan are still not clear. Epigenetic mechanisms have recently been recognized as major contributors to nutrition-related longevity and aging control. Two primary epigenetic codes, DNA methylation and histone modification, are believed to dynamically influence chromatin structure, resulting in expression changes of relevant genes. In this review, we assess the current advances in epigenetic regulation in response to caloric restriction and how this affects cellular senescence, aging and potential extension of a healthy lifespan in humans. Enhanced understanding of the important role of epigenetics in the control of the aging process through caloric restriction may lead to clinical advances in the prevention and therapy of human aging-associated diseases.

  11. 12 CFR 575.11 - Operating restrictions.


    ..., the reference in § 563b.510 of this chapter to five percent refers to minority shareholders. (d) Restrictions on waiver of dividends. No mutual holding company may waive its right to receive any dividend... holding company provides the OTS with written notice of its intent to waive its right to receive...

  12. 48 CFR 225.7007-1 - Restrictions.


    ... 48 Federal Acquisition Regulations System 3 2010-10-01 2010-10-01 false Restrictions. 225.7007-1 Section 225.7007-1 Federal Acquisition Regulations System DEFENSE ACQUISITION REGULATIONS SYSTEM... subsequent DoD appropriations acts, do not acquire welded shipboard anchor and mooring chain, four inches...

  13. 45 CFR 9.5 - Restrictions.


    ... DEPARTMENT OF HEALTH AND HUMAN SERVICES GENERAL ADMINISTRATION USE OF HHS RESEARCH FACILITIES BY ACADEMIC SCIENTISTS, ENGINEERS, AND STUDENTS § 9.5 Restrictions. (a) Each individual authorized to use Department... that the non-Government user will comply with all safety regulations and procedures while using...

  14. 36 CFR 331.18 - Restrictions.


    ... public health, public safety, security, maintenance, or other reasons in the public interest. Entering or... 331.18 Parks, Forests, and Public Property CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY REGULATIONS..., KENTUCKY AND INDIANA § 331.18 Restrictions. The District Engineer may establish and post a schedule...

  15. Restricted Liberty, Parental Choice and Homeschooling

    Merry, Michael S.; Karsten, Sjoerd


    In this paper the authors carefully study the problem of liberty as it applies to school choice, and whether there ought to be restricted liberty in the case of homeschooling. They examine three prominent concerns that might be brought against homeschooling, viz., that it aggravates social inequality, worsens societal conflict and works against…

  16. Restricted liberty, parental choice and homeschooling

    Merry, M.S.; Karsten, S.


    In this paper the authors carefully study the problem of liberty as it applies to school choice, and whether there ought to be restricted liberty in the case of homeschooling. They examine three prominent concerns that might be brought against homeschooling, viz., that it aggravates social inequalit

  17. 12 CFR 1805.808 - Lobbying restrictions.


    ... 12 Banks and Banking 7 2010-01-01 2010-01-01 false Lobbying restrictions. 1805.808 Section 1805.808 Banks and Banking COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS FUND, DEPARTMENT OF THE TREASURY COMMUNITY DEVELOPMENT FINANCIAL INSTITUTIONS PROGRAM Terms and Conditions of Assistance § 1805.808...

  18. Induced Modules of Restricted Lie Superalgebras



    In this paper we first prove the PBW theorem for reduced universal enveloping algebras of restricted Lie superalgebras. Then the notion of an induced module is introduced and the dimension formula of induced modules is established.Finally, using the results above, we obtain a property of induced modules pertaining to automorphisms of Lie superalgebras and isomorphisms of modules.

  19. Preventive maintenance at opportunities of restricted duration

    R. Dekker (Rommert); E. Smeitink


    textabstractThis article deals with the problem of setting priorities for the execution of maintenance packages at randomly occurring opportunities. These opportunities are of restricted duration, implying that only a limited number of packages can be executed. The main idea proposed is to set up a

  20. Restrictive cardiomyopathy. Report of seven cases

    Fonseca Sánchez Luis Alfonso


    Full Text Available Restrictive cardiomyopathy is a disease characterized by ventricular diastolic failure with elevation of end-dyastolic pressure and preserved systolic function. Materials and methods: retrospective study of patients with a diagnosis of restrictive cardiomyopathy. We carry out an analysis of demographic data, clinical presentation, and studies of patients diagnosed in the last 15 years at Instituto Nacional de Pediatría. Results: all included patients had clinical data of heart failure manifested mainly by medium-sized efforts dyspnea on schoolchildren and dyspnea by feeding in infants, as well as polypnea and diaphoresis. The most important signs were hepatomegaly, ascites, and gallop rhythm. Cardiomegaly by right atrial dilatation was the most frequent radiological data. The most frequent electrocardiographic data were dilatation of both atria, ST-segment depression and negative T waves. Echocardiogram showed in all cases binaural dilation and restrictive pattern. Conclusions: our patients were similar to those described in the specialized literature. Echocardiogram is still the best study for the diagnosis and the use of functional measurements as Doppler imaging can help to reveal early diastolic failure. In our country the heart transplant is just feasible; mortality remains 100%. Keywords: Restrictive cardiomyopathy, Heart failure, Cardiomyopathy.

  1. Mechanisms of Salmonella Typhi Host Restriction.

    Spanò, Stefania


    Salmonella enterica serovar Typhi (S. Typhi) is the cause of typhoid fever, a life-threatening bacterial infection that is very common in the developing world. Recent spread of antimicrobial resistant isolates of S. Typhi makes typhoid fever, a global public health risk. Despite being a common disease, still very little is known about the molecular mechanisms underlying typhoid fever and S. Typhi pathogenesis. In contrast to other Salmonellae, S. Typhi can only infect humans. The molecular bases of this human restriction are mostly unknown. Recent studies identified a novel pathway that contributes to S. Typhi human restriction and is required for killing S. Typhi in macrophages of nonsusceptible species. The small Rab GTPase Rab32 and its guanine nucleotide exchange factor BLOC-3 are the critical components of this pathway. These proteins were already well known as important regulators of intracellular membrane transport. In particular, they are central for the transport of enzymes that synthetize melanin in pigment cells. The recent findings that Rab32 and BLOC-3 are required for S. Typhi host restriction point out to a novel mechanism restricting the growth of bacterial pathogen, dependent on the transport of still unknown molecule(s) to the S. Typhi vacuole. The identification of this novel antimicrobial pathway constitutes a critical starting point to study molecular mechanisms killing bacterial pathogens and possibly identify novel antimicrobial molecules.

  2. Joint Venture Structuring in Restricted Industries



    When investing in China’s restricted in- dustries, it is essential to have a joint venture (JV) partner. Often the maximum percent- age of equity allowed in foreign ownership can only be 50 percent. So what options are available to the foreign investor to mitigate the risk of not owning, on paper, a majority

  3. 38 CFR 1.462 - Confidentiality restrictions.


    ... Drug Abuse, Alcoholism Or Alcohol Abuse, Infection with the Human Immunodeficiency Virus (hiv), Or....460 through 1.499 of this part apply may be disclosed or used only as permitted by these regulations...) Unconditional compliance required. The restrictions on disclosure and use in §§ 1.460 through 1.499 of this...

  4. Real Moments of the Restrictive Factor

    Andrew Ledoan; Alexandru Zaharescu


    Let be a real number such that 0 < < 1. We establish asymptotic formulas for the weighted real moments $\\sum_{n≤ x}R^(n)(1-n/x)$, where $R(n)=\\prod^k_{v=1}p^{ v-1}_v$ is the Atanassov strong restrictive factor function and $n=\\prod^k_{v=1}p^{ v}_v$ is the prime factorization of .

  5. Optimal Policy under Restricted Government Spending

    Sørensen, Anders


    Welfare ranking of policy instruments is addressed in a two-sector Ramsey model with monopoly pricing in one sector as the only distortion. When government spending is restricted, i.e. when a government is unable or unwilling to finance the required costs for implementing the optimum policy...

  6. 50 CFR 16.3 - General restrictions.


    ... INJURIOUS WILDLIFE Introduction § 16.3 General restrictions. Any importation or transportation of live... and welfare of human beings, to the interest of forestry, agriculture, and horticulture, and to the... into or the transportation of live wildlife or eggs thereof between the continental United States,...

  7. Material and Cultural Restriction of Political Life



    Material and culture have a certain influence on the political life. In general, the higher level of economic development of the country, people's political life is more democratic. Culture has some negative effect on the political life. China's traditional cul-ture has restricted the people's political life in some ways.

  8. Restrictive dermopathy - Report of 12 cases

    Smitt, JHS; van Asperen, CJ; Niessen, CM; Beemer, FA; van Essen, AJ; Hulsmans, RFHJ; Oranje, AP; Steijlen, PM; Wesby-van Swaay, E; Tamminga, P; Breslau-Siderius, EJ


    Background: This study describes 12 cases of restrictive dermopathy seen during a period of 8 years by the Dutch Task Force on Genodermatology. We present these unique consecutive cases to provide more insight into the clinical picture and pathogenesis of the disease. Observations: Clinical features

  9. Restricted total stability and total attractivity

    Giuseppe Zappala'


    Full Text Available In this paper the new concepts of restricted total stability and total attractivity is formulated. For this purpose the classical theory of Malkin with suitable changes and the theory of limiting equations, introduced by Sell developed by Artstein and Andreev, are used. Significant examples are presented.

  10. 50 CFR 622.45 - Restrictions on sale/purchase.


    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Restrictions on sale/purchase. 622.45... Management Measures § 622.45 Restrictions on sale/purchase. In addition to restrictions on sale/purchase related to closures, as specified in § 622.43 (a) and (b), restrictions on sale and/or purchase apply...

  11. 7 CFR 322.28 - General requirements; restricted articles.


    ... 7 Agriculture 5 2010-01-01 2010-01-01 false General requirements; restricted articles. 322.28... EQUIPMENT Importation and Transit of Restricted Articles § 322.28 General requirements; restricted articles. (a) The following articles from any region are restricted articles: (1) Dead bees of any genus;...

  12. 7 CFR 319.75-2 - Restricted articles. 1


    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Restricted articles. 1 319.75-2 Section 319.75-2... SERVICE, DEPARTMENT OF AGRICULTURE FOREIGN QUARANTINE NOTICES Khapra Beetle § 319.75-2 Restricted articles. 1 1 The importation of restricted articles may be subject to prohibitions or restrictions...

  13. Impacts of Left Lane Truck Restriction on Urban Freeways

    Yang, Choon-Heon; Regan, A C


    This paper examines the impacts of truck lane restriction on urban freeways using traffic simulation models. The study includes three main parts: Part (1) provides insights into conditions under which truck lane restrictions would work well; Part (2) identifies the best number of lanes to restrict and shows that this is an important factor in the success of lane restriction; Part (3) investigates potential impacts of truck lane restriction through a case study using a region with some of the ...

  14. Programmable DNA-Guided Artificial Restriction Enzymes.

    Enghiad, Behnam; Zhao, Huimin


    Restriction enzymes are essential tools for recombinant DNA technology that have revolutionized modern biological research. However, they have limited sequence specificity and availability. Here we report a Pyrococcus furiosus Argonaute (PfAgo) based platform for generating artificial restriction enzymes (AREs) capable of recognizing and cleaving DNA sequences at virtually any arbitrary site and generating defined sticky ends of varying length. Short DNA guides are used to direct PfAgo to target sites for cleavage at high temperatures (>87 °C) followed by reannealing of the cleaved single stranded DNAs. We used this platform to generate over 18 AREs for DNA fingerprinting and molecular cloning of PCR-amplified or genomic DNAs. These AREs work as efficiently as their naturally occurring counterparts, and some of them even do not have any naturally occurring counterparts, demonstrating easy programmability, generality, versatility, and high efficiency for this new technology.

  15. Dietary Restriction and Nutrient Balance in Aging

    Júlia Santos


    Full Text Available Dietary regimens that favour reduced calorie intake delay aging and age-associated diseases. New evidences revealed that nutritional balance of dietary components without food restriction increases lifespan. Particular nutrients as several nitrogen sources, proteins, amino acid, and ammonium are implicated in life and healthspan regulation in different model organisms from yeast to mammals. Aging and dietary restriction interact through partially overlapping mechanisms in the activation of the conserved nutrient-signalling pathways, mainly the insulin/insulin-like growth factor (IIS and the Target Of Rapamycin (TOR. The specific nutrients of dietary regimens, their balance, and how they interact with different genes and pathways are currently being uncovered. Taking into account that dietary regimes can largely influence overall human health and changes in risk factors such as cholesterol level and blood pressure, these new findings are of great importance to fully comprehend the interplay between diet and humans health.

  16. Affective tone of mothers' statements to restrict their children's eating.

    Pesch, Megan H; Miller, Alison L; Appugliese, Danielle P; Rosenblum, Katherine L; Lumeng, Julie C


    Maternal restrictive feeding behaviors have been associated with child weight status. The affective tone of mothers' statements intended to restrict their children's eating has not been examined. The objectives of this study were to describe the affective tone of mothers' restrictive feeding behaviors (positive or negative), and to test the association of child and mother characteristics with rates of Restriction with Positive Affect, Restriction with Negative Affect and Total Restriction. A total of 237 low-income child-mother dyads (mean child age 5.9 years) participated in a videotaped standardized laboratory eating protocol, during which mothers and children were both presented with large servings of cupcakes. A coding scheme was developed to count each restrictive statement with a positive affective tone and each restrictive statement with a negative affective tone. To establish reliability, 20% of videos were double-coded. Demographics and anthropometrics were obtained. Poisson regression models were used to test the association between characteristics of the child and mother with counts of Restriction with Positive Affect, Restriction with Negative Affect, and Total Restriction. Higher rates of Restriction with Positive Affect and Total Restriction were predicted by child obese weight status, and mother non-Hispanic white race/ethnicity. Higher rates of Restriction with Negative Affect were predicted by older child age, child obese weight status, mother non-Hispanic white race/ethnicity, and lower mother education level. In conclusion, in this study mothers of obese (vs. non-obese) children had higher rates of restriction in general, but particularly higher rates of Restriction with Negative Affect. Rather than being told not to restrict, mothers may need guidance on how to sensitively restrict their child's intake. Future studies should consider the contributions of maternal affect to children's responses to maternal restriction.

  17. Beyond Intergovernmentalism: The Europeanization of Restrictive Measures?

    Francesco Giumelli


    Full Text Available The functioning of the European Union (EU has been explored extensively in recent years. The dominant prism through which to look at the EU is still one of locus: i.e. whether decisions are made in the capitals of its member states or in Brussels. This debate is contained in the dualism between intergovernmentalism and supranationalism, but drawing the boundaries between the two concepts is still undone. This article attempts to contribute to solving this problem by investigating the restrictive measures policy of the EU in order to identify three conditions under which intergovernmentalism should be used. First, when EU institutions are dependent on EU member states for information and expertise; second, when decision-making powers rest mainly in EU capitals; and three, when there are no exclusive fora for decision-making in Brussels. The study of the restrictive measures of the European Union does not meet any of these three conditions; therefore the article argues that the concept of supranational intergovernmentalism offers useful insights to understand the EU security governance of CFSP sanctions. The article is divided into four parts. The first introduces the debate on security governance and justifies the selection of this specific approach to the study of sanctions. The second part presents the restrictive measures policy of the European Union and justifies its pertinence to the field of security. The third part of the article investigates the emerging patterns in security governance by testing the three conditions on the decision-making process for EU restrictive measures. Finally, the conclusion summarises the main argument and indicates ways forward in the study of EU sanctions from a governance perspective.

  18. Restricted Conformal Property of Compressive Sensing

    Cheng, Tao


    Energy and direction are tow basic properties of a vector. A discrete signal is a vector in nature. RIP of compressive sensing can not show the direction information of a signal but show the energy information of a signal. Hence, RIP is not complete. Orthogonal matrices can preserve angles and lengths. Preservation of length can show energies of signals like RIP do; and preservation of angle can show directions of signals. Therefore, Restricted Conformal Property (RCP) is proposed according t...

  19. Restriction endonucleases digesting DNA in PCR buffer

    LIU Xue-dong; ZHENG Dong; ZHOU Yan-na; MAO Wei-wei; MA Jian-zhang


    Six commonly used restriction endonucleases (Res) (Acc I, Ban II, EcoR I, Hind III, Sac I, Sca I) were tested for their ability to directly digest DNA completely in the Polymerase Chain Reaction (PCR) buffers. The results showed that: with the requirement for additional magnesium supplemented as activator, Res, except EcoR I appeared star activity, completely digested unmethylated lambda DNA after overnight incubation in PCR buffer and functioned as equally well as in recommended Restriction Enzyme Buffer provided with each enzyme; all Res tested completely digested PCR products in PCR buffer, it implied digestion of PCR products may often be performed directly in the PCR tube without the requirement for any precipitation or purification steps; and the concentration of MgCl2 from 2.5 mmol·L-1 to 10 mmol·L-1 did not significantly affect activity of Res in PCR buffer. This simplified method for RE digestion of PCR products could have applications in restriction fragment length polymorphism (RFLP) analysis and single-stranded conformational polymorphism (SSCP) analysis of large PCR products. However, usage of this procedure for cloning applications needs further data.

  20. Team Formation and Communication Restrictions in Collectives

    Agogino, Adrian K.; Turner, Kagan


    A collective of agents often needs to maximize a "world utility" function which rates the performance of an entire system, while subject to communication restrictions among the agents. Such communication restrictions make it difficult for agents which try to pursue their own "private" utilities to take actions that also help optimize the world utility. Team formation presents a solution to this problem, where by joining other agents, an agent can significantly increase its knowledge about the environment and improve its chances of both optimizing its own utility and that its doing so will contribute to the world utility. In this article we show how utilities that have been previously shown to be effective in collectives can be modified to be more effective in domains with moderate communication restrictions resulting in performance improvements of up to 75%. Additionally we show that even severe communication constraints can be overcome by forming teams where each agent of a team shares the same utility, increasing performance an additional 25%. We show that utilities and team sizes can be manipulated to form the best compromise between how "aligned" an agent s utility is with the world utility and how easily an agent can learn that utility.

  1. Type I restriction enzymes and their relatives.

    Loenen, Wil A M; Dryden, David T F; Raleigh, Elisabeth A; Wilson, Geoffrey G


    Type I restriction enzymes (REases) are large pentameric proteins with separate restriction (R), methylation (M) and DNA sequence-recognition (S) subunits. They were the first REases to be discovered and purified, but unlike the enormously useful Type II REases, they have yet to find a place in the enzymatic toolbox of molecular biologists. Type I enzymes have been difficult to characterize, but this is changing as genome analysis reveals their genes, and methylome analysis reveals their recognition sequences. Several Type I REases have been studied in detail and what has been learned about them invites greater attention. In this article, we discuss aspects of the biochemistry, biology and regulation of Type I REases, and of the mechanisms that bacteriophages and plasmids have evolved to evade them. Type I REases have a remarkable ability to change sequence specificity by domain shuffling and rearrangements. We summarize the classic experiments and observations that led to this discovery, and we discuss how this ability depends on the modular organizations of the enzymes and of their S subunits. Finally, we describe examples of Type II restriction-modification systems that have features in common with Type I enzymes, with emphasis on the varied Type IIG enzymes.

  2. Emergency building temperature restrictions. Final evaluation



    On July 5, 1979, DOE promulgated final regulations of the Emergency Building Temperature Restrictions program, placing emergency restrictions on thermostat settings for space heating, space cooling, and hot water in commercial, industrial, and nonresidential public buildings. The final regulations restricted space heating to a maximum of 65/sup 0/F, hot water temperature to a maximum of 105/sup 0/F, and cooling temperature to a minimum of 78/sup 0/F. A comprehensive evaluation of the entire EBTF program for a nine-month period from July 16, 1979 is presented. In Chapter 1, an estimate of the population of buildings covered by EBTR is presented. In Chapter 2, EBTR compliance by building type and region is reported. Exemptions are also discussed. In Chapter 3, the simulations of building energy use are explained and the relative impact of various building characteristics and effectiveness of different control strategies are estimated. Finally, in Chapter 4, the methodology for scaling the individual building energy savings to the national level is described, and estimated national energy savings are presented.

  3. Food restriction modifies ultrastructure of hippocampal synapses.

    Babits, Réka; Szőke, Balázs; Sótonyi, Péter; Rácz, Bence


    Consumption of high-energy diets may compromise health and may also impair cognition; these impairments have been linked to tasks that require hippocampal function. Conversely, food restriction has been shown to improve certain aspects of hippocampal function, including spatial memory and memory persistence. These diet-dependent functional changes raise the possibility that the synaptic structure underlying hippocampal function is also affected. To examine how short-term food restriction (FR) alters the synaptic structure of the hippocampus, we used quantitative electron microscopy to analyze the organization of neuropil in the CA1 stratum radiatum of the hippocampus in young rats, consequent to reduced food. While four weeks of FR did not modify the density, size, or shape of postsynaptic spines, the synapses established by these spines were altered, displaying increased mean length, and more frequent perforations of postsynaptic densities. That the number of perforated synapses (believed to be an indicator of synaptic enhancement) increased, and that the CA1 spine population had on average significantly longer PSDs suggests that synaptic efficacy of axospinous synapses also increased in the CA1. Taken together, our ultrastructural data reveal previously unrecognized structural changes at hippocampal synapses as a function of food restriction, supporting a link between metabolic balance and synaptic plasticity.

  4. Restriction enzyme-mediated DNA family shuffling.

    Behrendorff, James B Y H; Johnston, Wayne A; Gillam, Elizabeth M J


    DNA shuffling is an established recombinatorial method that was originally developed to increase the speed of directed evolution experiments beyond what could be accomplished using error-prone PCR alone. To achieve this, mutated copies of a protein-coding sequence are fragmented with DNase I and the fragments are then reassembled in a PCR without primers. The fragments anneal where there is sufficient sequence identity, resulting in full-length variants of the original gene that have inherited mutations from multiple templates. Subsequent studies demonstrated that directed evolution could be further accelerated by shuffling similar native protein-coding sequences from the same gene family, rather than mutated variants of a single gene. Generally at least 65-75 % global identity between parental sequences is required in DNA family shuffling, with recombination mostly occurring at sites with at least five consecutive nucleotides of local identity. Since DNA shuffling was originally developed, many variations on the method have been published. In particular, the use of restriction enzymes in the fragmentation step allows for greater customization of fragment lengths than DNase I digestion and avoids the risk that parental sequences may be over-digested into unusable very small fragments. Restriction enzyme-mediated fragmentation also reduces the occurrence of undigested parental sequences that would otherwise reduce the number of unique variants in the resulting library. In the current chapter, we provide a brief overview of the alternative methods currently available for DNA shuffling as well as a protocol presented here that improves on several previous implementations of restriction enzyme-mediated DNA family shuffling, in particular with regard to purification of DNA fragments for reassembly.

  5. A new restriction endonuclease from Spirulina platensis.

    Kawamura, M; Sakakibara, M; Watanabe, T; Kita, K.; Hiraoka, N; Obayashi, A; Takagi, M; Yano, K


    Three restriction endonucleases, Sp1I, Sp1II and Sp1III have been purified partially from Spirulina platensis subspecies siamese and named. Sp1I cleaves bacteriophage lambda DNA at one site, phi X 174 RF DNA at two sites, but does not cleave pBR322 DNA. This enzyme recognizes the sequence 5'CGTACG3' 3'GCATCG5' and cuts the site indicated by the arrows. Sp1II is an isoschizomer of Tth111I and Sp1III is an isoschizomer of HaeIII.

  6. Restricted fish feeding reduces cod otolith opacity

    Høie, H.; Folkvord, A.; Mosegaard, Henrik


    The purpose of this work was to examine the effect of reduced feeding and constant temperature on cod otolith opacity. Three groups of juvenile cod were given restricted food rations at different times for 4 months, resulting in depressed somatic growth. Otolith opacity was measured on pictures...... in otolith opacity were found between individual fish both within groups and between groups. In two of the three groups significantly more translucent otolith material was deposited in response to reduced feeding. Our results show that variations in feeding and hence fish growth resulted in variation...

  7. The Monetary Policy – Restrictive or Expansive?

    Adam Szafarczyk


    Full Text Available The monetary policy plays an important role in macroeconomic policy of government. There is a question concerning type of this policy expansive or restrictive (easy or tidy monetary policy. Unfortunately, we have a lot of criteria. Each of them gives us other answer. So due to equitation of Irving Fisher we have dominantly expansive monetary policy. This same situation exists when we use nominal value of rediscount interest rate of central bank. Opposite result appears when we use real value of this interest rate or level of obligatory reserve. Taking under consideration liquidity on money market we know, that level of interest rate is too high.

  8. A User-Friendly Method for Teaching Restriction Enzyme Mapping.

    Ehrman, Patrick


    Presented is a teaching progression that enhances learning through low-cost, manipulative transparencies. Discussed is instruction about restriction enzymes, plasmids, cutting plasmids, plasmid maps, recording data, and mapping restriction sites. Mapping wheels for student use is included. (CW)

  9. Medical Expenditure Panel Survey (MEPS) Restricted Data Files

    U.S. Department of Health & Human Services — Restricted Data Files Available at the Data Centers Researchers and users with approved research projects can access restricted data files that have not been...

  10. Repletion of TNFα or leptin in calorically restricted mice suppresses post-restriction hyperphagia

    Hambly, Catherine; Duncan, Jacqueline S.; Archer, Zoë A.; Moar, Kim M.; Mercer, Julian G.; Speakman, John R.


    SUMMARY The causes of post-restriction hyperphagia (PRH) represent a target for drug-based therapies to prevent obesity. However, the factors causing PRH are poorly understood. We show that, in mice, the extent of PRH was independent of the time under restriction, but depended on its severity, suggesting that PRH was driven by signals from altered body composition. Signals related to fat mass were important drivers. Circulating levels of leptin and TNFα were significantly depleted following caloric restriction (CR). We experimentally repleted their levels to match those of controls, and found that in both treatment groups the level of PRH was significantly blunted. These data establish a role for TNFα and leptin in the non-pathological regulation of energy homeostasis. Signals from adipose tissue, including but not limited to leptin and TNFα, regulate PRH and might be targets for therapies that support people engaged in CR to reduce obesity. PMID:21954068

  11. 48 CFR 552.203-71 - Restriction on Advertising.


    ... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Restriction on Advertising... Restriction on Advertising. As prescribed in 503.570-2, insert the following clause: Restriction on Advertising (SEP 1999) The Contractor shall not refer to this contract in commercial advertising or...

  12. 7 CFR 930.15 - Restricted percentage cherries.


    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Restricted percentage cherries. 930.15 Section 930.15... Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE TART CHERRIES GROWN IN THE STATES... Handling Definitions § 930.15 Restricted percentage cherries. Restricted percentage cherries means...

  13. 7 CFR 1724.8 - Restrictions on lobbying.


    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Restrictions on lobbying. 1724.8 Section 1724.8 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF... Restrictions on lobbying. Borrowers shall comply with the restrictions and requirements in connection...

  14. 14 CFR 1310.9 - Restrictions on lobbying.


    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Restrictions on lobbying. 1310.9 Section... CONDITION OF GUARANTEED LOAN § 1310.9 Restrictions on lobbying. (a) While the Board is not part of the... Restrictions on Lobbying”) of title 31 (“Money and Finance: Treasury”) of the Code of Federal Regulations...

  15. 7 CFR 1710.125 - Restrictions on lobbying.


    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Restrictions on lobbying. 1710.125 Section 1710.125... and Basic Policies § 1710.125 Restrictions on lobbying. Borrowers are required to comply with certain requirements with respect to restrictions on lobbying activities. See 7 CFR part 3018....

  16. 14 CFR 1274.929 - Restrictions on lobbying.


    ... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Restrictions on lobbying. 1274.929 Section... WITH COMMERCIAL FIRMS Other Provisions and Special Conditions § 1274.929 Restrictions on lobbying. Restrictions on Lobbying July 2002 This award is subject to the provisions of 14 CFR part 1271...

  17. 10 CFR 1016.34 - Accountability for Secret Restricted Data.


    ... 10 Energy 4 2010-01-01 2010-01-01 false Accountability for Secret Restricted Data. 1016.34 Section... Information § 1016.34 Accountability for Secret Restricted Data. Each permittee possessing documents containing Secret Restricted Data shall establish a document accountability procedure and shall...

  18. Neural Correlates of Restricted, Repetitive Behaviors in Autism Spectrum Disorders


    Restrictive Repetitive Behaviors in Autism Spectrum Disorder . Authors: T.Q.Nguyen, B...Manoach. Functional Connectivity of the Dorsal Anterior Cingulate Cortex Predicts Restrictive Repetitive Behaviors in Autism Spectrum Disorder We...Introduction: Although restricted , repetitive behaviors (RRBs) are a highly disabling core feature of Autism Spectrum Disorders (ASDs), they

  19. Intermittent′ restrictive ventricular septal defect in Tetralogy of Fallot

    Sudhir S Shetkar


    Full Text Available Ventricular septal defect (VSD in Tetralogy of Fallot (TOF is usually large and non-restrictive with equalization of right and left ventricular pressures. Restrictive VSD in TOF is rare. We present an unusual case of TOF with restriction to VSD caused by accessory tricuspid valve tissue that varied with respiration.

  20. 36 CFR 13.1174 - Whale water restrictions.


    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Whale water restrictions. 13... Vessel Operating Restrictions § 13.1174 Whale water restrictions. (a) May 15 through September 30, the following waters are designated as whale waters. (1) Waters north of a line drawn from Point Carolus...

  1. Restrictions on autogressive error processes in systems of demand equations

    Brown, Mark G.


    Alternative theoretically based restrictions on autoregressive error processes in systems of demand equations are examined. Scaling, translation, and a utility-based approach suggested by Theil are used to generate restrictions. A study of juice demands suggests that the restrictions examined may be useful for empirical analysis.

  2. Oncogenic pathways impinging on the G2-restriction point

    Foijer, F; Simonis, M; van Vliet, M; Wessels, L; Kerkhoven, R; Sorger, P K; Te Riele, H


    In the absence of mitogenic stimuli, cells normally arrest in G(1/0), because they fail to pass the G1-restriction point. However, abrogation of the G1-restriction point (by loss of the retinoblastoma gene family) reveals a second-restriction point that arrests cells in G2. Serum-starvation-induced

  3. 50 CFR 697.23 - Restricted gear areas.


    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Restricted gear areas. 697.23 Section 697... Measures § 697.23 Restricted gear areas. (a) Resolution of lobster gear conflicts with fisheries managed...) Restricted Gear Area I—(1) Duration—(i) Mobile Gear. From October 1 through June 15 of each fishing year,...

  4. 14 CFR 252.8 - Extent of smoking restrictions.


    ... 14 Aeronautics and Space 4 2010-01-01 2010-01-01 false Extent of smoking restrictions. 252.8... PROCEEDINGS) ECONOMIC REGULATIONS SMOKING ABOARD AIRCRAFT § 252.8 Extent of smoking restrictions. The restrictions on smoking described in §§ 252.3 through 252.7 shall apply to all locations within the aircraft....

  5. Communication restriction in adults who stutter.

    Lee, Amanda; Van Dulm, Ondene; Robb, Michael P; Ormond, Tika


    This study explored communication restriction in adults with stuttering (AWS) by means of typical language measures obtained using the Systematic Analysis of Language Transcripts - New Zealand (SALT-NZ) software, as well as systemic functional linguistics (SFL) analyses. The areas of language productivity and complexity, modality (i.e. linguistic politeness) and the language of appraisal were compared between AWS and typically fluent speakers (adults with no stuttering (AWNS)). Ten-minute conversational samples were obtained from 20 AWS and 20 age- and sex-matched AWNS. Transcripts were analysed for quantity and complexity of verbal output, and frequency of use of modality and appraisal resource subtypes. Means comparison and correlation analyses were conducted using grouped data. AWS produced less language and less complex language than AWNS, measured by SALT-NZ and SFL indices. AWS also differed from AWNS in their use of modality resources to express politeness - they produced fewer modal operators and more comment adjuncts than AWNS. A smaller proportion of their language expressed the explicit appreciation of things. The linguistic patterns identified in the conversational language of AWS suggested a reduced openness to interpersonal engagement within communication exchanges, which may restrict opportunities for and the experience of such exchanges. The value of SFL to this area of research is discussed.

  6. A FORTRAN Program for Correcting Correlation Coefficients for Restriction in Range for Explicit or Implicit Restriction.

    Lewis, Mary A.; Boone, James O.


    Restriction in range is a measurement problem frequently encountered in research studies that utilize correlation coefficients. A FORTRAN program is described that can compute the estimated unrestricted correlation coefficient in either the explicit or implicit case. The user selects the appropriate formula to be employed from five that are…

  7. Formation reconfiguration in restricted three body problem

    Shengping Gong; Junfeng Li; Hexi Baoyin; Yunfeng Gao


    Reconfiguration of formation flying around a halo orbit of the Sun-Earth restricted three body system is investigated with impulse maneuvers. For a short time reconfiguration, the two-impulse maneuver is investigated with both analytical and numerical methods and the BeginningEnding (BE) method is proven to be an energy-optimal one of all two-impulse (TI) reconfigurations, and the energy consumption of BE is independent of the position of the chief spacecraft, and decreases with the reconfiguration time.Then, genetic algorithm is adopted to optimize the energy consumption. The results show that the optimal energy increases with radius difference between the initial and final orbits, and decreases with the reconfiguration time.

  8. Constrictive Pericarditis Versus Restrictive Cardiomyopathy?

    Garcia, Mario J


    About one-half of the patients with congestive heart failure have preserved left ventricular ejection fraction (HFpEF). Although the etiology of HFpEF is most commonly related to long-standing hypertension and atherosclerosis, a significant number of suspected HFpEF patients have a restrictive cardiomyopathy or chronic pericardial disease. Recognizing these syndromes is important because early diagnosis may lead to instituting specific therapy that may prolong survival, improve quality of life, and/or recognize and treat an underlying systemic disorder. Advances in diagnostic imaging, biomarkers, and genetic testing today allow identification of the specific etiology in most cases. Novel pharmacological, immunologic, and surgical therapies are leading to improved quality of life and survival.

  9. Classification of Sets using Restricted Boltzmann Machines

    Louradour, Jérôme


    We consider the problem of classification when inputs correspond to sets of vectors. This setting occurs in many problems such as the classification of pieces of mail containing several pages, of web sites with several sections or of images that have been pre-segmented into smaller regions. We propose generalizations of the restricted Boltzmann machine (RBM) that are appropriate in this context and explore how to incorporate different assumptions about the relationship between the input sets and the target class within the RBM. In experiments on standard multiple-instance learning datasets, we demonstrate the competitiveness of approaches based on RBMs and apply the proposed variants to the problem of incoming mail classification.

  10. Restriction Enzymes in Microbiology, Biotechnology and Biochemistry

    Geoffrey G. Wilson


    Full Text Available Since their discovery in the nineteen-seventies, a collection of simple enzymes termed Type II restriction endonucleases, made by microbes to ward off viral infections, have transformed molecular biology, spawned the multi-billion dollar Biotechnology industry, and yielded fundamental insights into the biochemistry of life, health and disease. In this article we describe how these enzymes were discovered, and we review their properties, organizations and genetics. We summarize current ideas about the mechanism underlying their remarkable ability to recognize and bind to specific base pair sequences in DNA, and we discuss why these ideas might not be correct. We conclude by proposing an alternative explanation for sequence-recognition that resolves certain inconsistencies and provides, in our view, a more satisfactory account of the mechanism.

  11. Training Restricted Boltzmann Machines on Word Observations

    Dahl, George E; Larochelle, Hugo


    The restricted Boltzmann machine (RBM) is a flexible tool for modeling complex data, however there have been significant computational difficulties in using RBMs to model high-dimensional multinomial observations. In natural language processing applications, words are naturally modeled by K-ary discrete distributions, where K is determined by the vocabulary size and can easily be in the hundred thousands. The conventional approach to training RBMs on word observations is limited because it requires sampling the states of K-way softmax visible units during block Gibbs updates, an operation that takes time linear in K. In this work, we address this issue by employing a more general class of Markov chain Monte Carlo operators on the visible units, yielding updates with computational complexity independent of K. We demonstrate the success of our approach by training RBMs on hundreds of millions of word n-grams using larger vocabularies than previously feasible with RBMs and using the learned features to improve p...

  12. Mining for Restriction Endonucleases in Nicaragua

    Suyén S. Espinoza-Miranda


    Full Text Available The Molecular Biology Center at the University of Central America in Nicaragua (CBM-UCA was founded in 1999 to strengthen biotechnology research capacity and education in Nicaragua and the Central American region. One of the first projects launched by the CBM-UCA was bio-prospecting for key industrial enzymes. This ongoing study seeks to discover and characterize restriction enzymes (RE in bacteria, and to create a database of microorganisms isolated and identified by 16S rDNA sequencing methodology. In this paper we highlight the importance of studying the extreme environmental conditions for building knowledge of Nicaraguan biodiversity through modern molecular biology techniques such as metagenomics. The isolation of prototype enzymes such as EcoRV and ClaI is presented as an update and extension of previously undertaken work.

  13. Epitaxial growth by monolayer restricted galvanic displacement

    Vasilić Rastko


    Full Text Available The development of a new method for epitaxial growth of metals in solution by galvanic displacement of layers pre-deposited by underpotential deposition (UPD was discussed and experimentally illustrated throughout the lecture. Cyclic voltammetry (CV and scanning tunneling microscopy (STM are employed to carry out and monitor a “quasi-perfect”, two-dimensional growth of Ag on Au(111, Cu on Ag(111, and Cu on Au(111 by repetitive galvanic displacement of underpotentially deposited monolayers. A comparative study emphasizes the displacement stoichiometry as an efficient tool for thickness control during the deposition process and as a key parameter that affects the deposit morphology. The excellent quality of layers deposited by monolayer-restricted galvanic displacement is manifested by a steady UPD voltammetry and ascertained by a flat and uniform surface morphology maintained during the entire growth process.

  14. Trophoblast differentiation, fetal growth restriction and preeclampsia.

    Huppertz, Berthold


    The number of hypotheses trying to decipher the etiologies of preeclampsia and fetal growth restriction (FGR) is still increasing. However, for preeclampsia the actual knowledge we have is that the placenta is a prerequisite for the development of the syndrome. The recent years have seen a shift in understanding of the causes of preeclampsia from mostly focusing on the extravillous trophoblast towards the dysregulation of villous trophoblast development and maintenance. It seems as if a failure of the villous syncytiotrophoblast differentiation results in abnormal release of non-apoptotic fragments into maternal blood. In preeclampsia such necrotic or aponecrotic fragments can be found in maternal blood systemically and seem to be causative in the development of the inflammatory response of the mother. In cases with fetal growth restriction (FGR) extravillous trophoblast fails to adequately transform uterine spiral arteries. However, in FGR cases abnormal development of villous cytotrophoblast may have an impact on fetal nutrition without the induction of an inflammatory response of the mother. It is still unclear why the villous trophoblast fails to achieve an adequate turnover both in preeclampsia and in FGR. However, the detection of new biomarkers for preeclampsia such as placental protein 13 (PP13) has helped in clarifying the issue of when the syndrome starts to develop. PP13 levels in maternal serum are significantly altered already at six to seven weeks of gestation in women subsequently developing preeclampsia. Thus, there needs to be a very early alteration of villous development in such placentas. Herein the changes in villous trophoblast in preeclampsia and FGR are compared and differences between both scenarios are presented.

  15. AGORA: Assembly Guided by Optical Restriction Alignment

    Lin Henry C


    Full Text Available Abstract Background Genome assembly is difficult due to repeated sequences within the genome, which create ambiguities and cause the final assembly to be broken up into many separate sequences (contigs. Long range linking information, such as mate-pairs or mapping data, is necessary to help assembly software resolve repeats, thereby leading to a more complete reconstruction of genomes. Prior work has used optical maps for validating assemblies and scaffolding contigs, after an initial assembly has been produced. However, optical maps have not previously been used within the genome assembly process. Here, we use optical map information within the popular de Bruijn graph assembly paradigm to eliminate paths in the de Bruijn graph which are not consistent with the optical map and help determine the correct reconstruction of the genome. Results We developed a new algorithm called AGORA: Assembly Guided by Optical Restriction Alignment. AGORA is the first algorithm to use optical map information directly within the de Bruijn graph framework to help produce an accurate assembly of a genome that is consistent with the optical map information provided. Our simulations on bacterial genomes show that AGORA is effective at producing assemblies closely matching the reference sequences. Additionally, we show that noise in the optical map can have a strong impact on the final assembly quality for some complex genomes, and we also measure how various characteristics of the starting de Bruijn graph may impact the quality of the final assembly. Lastly, we show that a proper choice of restriction enzyme for the optical map may substantially improve the quality of the final assembly. Conclusions Our work shows that optical maps can be used effectively to assemble genomes within the de Bruijn graph assembly framework. Our experiments also provide insights into the characteristics of the mapping data that most affect the performance of our algorithm, indicating the

  16. Nutrient intake and food restriction in children with atopic dermatitis.

    Lim, Hyunjin; Song, Kyunghee; Kim, Ran; Sim, Jiyeon; Park, Eunah; Ahn, Kangmo; Kim, Jihyun; Han, Youngshin


    This study was performed to investigate the status of food restriction and the list of restricted foods in children with moderate to severe atopic dermatitis (AD), and to find out the effect of food restriction on the changes in nutrient intake and the severity of the disease. Sixty two patient children aged 12 months to 13 years presenting AD with a SCORing of Atopic Dermatitis (SCORAD) index between 20 and 50 were enrolled. The presence of food limitation, and list of restricted foods were surveyed through the caretakers and the patients were divided into 3 groups by the number of restricted food: non-restricted group, one to three restricted group, and more than three restricted group. Dietary intake was assessed for 3 months using a food frequency questionnaire (FFQ). Half of the subjects restricted foods. The restriction was higher in the order of soda, food additives, walnut, peanut, and other nuts as a single food item; and shellfish and crustacean group, processed foods, nuts, milk & dairy products, and meats as a food group. More than three restricted group ingested more fruits and less fish and meats, resulting in high consumption of vitamin C (p = 0.027). No significant difference in the ratio of nutrient intake by the number of restricted foods was observed in other nutrients. Significant improvement of AD symptom was observed in non-restricted group (p = 0.036) and one to three restricted group (p = 0.003). It is necessary to provide proper nutrition information and systematic and continuous nutrition management for balanced nutrient intake and disease improvement in children with AD.

  17. Restriction of bacteriophage plaque formation in Streptomyces spp.

    Cox, K L; Baltz, R H


    Several Streptomyces species that produce restriction endonucleases were characterized for their ability to propagate 10 different broad host range bacteriophages. Each species displayed a different pattern of plaque formation. A restrictionless mutant of S. albus G allowed plaque formation by all 10 phages, whereas the wild-type strain showed plaques with only 2 phages. DNA isolated from three of the phages was analyzed for the presence of restriction sites for Streptomyces species-encoded enzymes, and a very strong correlation was established between the failure to form plaques on Streptomyces species that produced particular restriction enzymes and the presence of the corresponding restriction sites in the phage DNA. Also, the phages that lacked restriction sites in their DNA generally formed plaques on the corresponding restriction endonuclease-producing hosts at high efficiency. The DNAs from the three phages analyzed also generally contained either many or no restriction sites for the Streptomyces species-produced enzymes, suggesting a strong evolutionary trend to either eliminate all or tolerate many restriction sites. The data indicate that restriction plays a major role in host range determination for Streptomyces phages. Analysis of bacteriophage host ranges of many other uncharacterized Streptomyces hosts has identified four relatively nonrestricting hosts, at least two of which may be suitable hosts for gene cloning. The data also suggest that several restriction systems remain to be identified in the genus Streptomyces.

  18. Detection of possible restriction sites for type II restriction enzymes in DNA sequences.

    Gagniuc, P; Cimponeriu, D; Ionescu-Tîrgovişte, C; Mihai, Andrada; Stavarachi, Monica; Mihai, T; Gavrilă, L


    In order to make a step forward in the knowledge of the mechanism operating in complex polygenic disorders such as diabetes and obesity, this paper proposes a new algorithm (PRSD -possible restriction site detection) and its implementation in Applied Genetics software. This software can be used for in silico detection of potential (hidden) recognition sites for endonucleases and for nucleotide repeats identification. The recognition sites for endonucleases may result from hidden sequences through deletion or insertion of a specific number of nucleotides. Tests were conducted on DNA sequences downloaded from NCBI servers using specific recognition sites for common type II restriction enzymes introduced in the software database (n = 126). Each possible recognition site indicated by the PRSD algorithm implemented in Applied Genetics was checked and confirmed by NEBcutter V2.0 and Webcutter 2.0 software. In the sequence NG_008724.1 (which includes 63632 nucleotides) we found a high number of potential restriction sites for ECO R1 that may be produced by deletion (n = 43 sites) or insertion (n = 591 sites) of one nucleotide. The second module of Applied Genetics has been designed to find simple repeats sizes with a real future in understanding the role of SNPs (Single Nucleotide Polymorphisms) in the pathogenesis of the complex metabolic disorders. We have tested the presence of simple repetitive sequences in five DNA sequence. The software indicated exact position of each repeats detected in the tested sequences. Future development of Applied Genetics can provide an alternative for powerful tools used to search for restriction sites or repetitive sequences or to improve genotyping methods.

  19. Mechanistic insights into type III restriction enzymes.

    Raghavendra, Nidhanapati K; Bheemanaik, Shivakumara; Rao, Desirazu N


    Type III restriction-modification (R-M) enzymes need to interact with two separate unmethylated DNA sequences in indirectly repeated, head-to-head orientations for efficient cleavage to occur at a defined location next to only one of the two sites. However, cleavage of sites that are not in head-to-head orientation have been observed to occur under certain reaction conditions in vitro. ATP hydrolysis is required for the long-distance communication between the sites prior to cleavage. Type III R-M enzymes comprise two subunits, Res and Mod that form a homodimeric Mod2 and a heterotetrameric Res2Mod2 complex. The Mod subunit in M2 or R2M2 complex recognizes and methylates DNA while the Res subunit in R2M2 complex is responsible for ATP hydrolysis, DNA translocation and cleavage. A vast majority of biochemical studies on Type III R-M enzymes have been undertaken using two closely related enzymes, EcoP1I and EcoP15I. Divergent opinions about how the long-distance interaction between the recognition sites exist and at least three mechanistic models based on 1D- diffusion and/or 3D- DNA looping have been proposed.

  20. Maternal dietary restriction alters offspring's sleep homeostasis.

    Noriyuki Shimizu

    Full Text Available Nutritional state in the gestation period influences fetal growth and development. We hypothesized that undernutrition during gestation would affect offspring sleep architecture and/or homeostasis. Pregnant female mice were assigned to either control (fed ad libitum; AD or 50% dietary restriction (DR groups from gestation day 12 to parturition. After parturition, dams were fed AD chow. After weaning, the pups were also fed AD into adulthood. At adulthood (aged 8-9 weeks, we carried out sleep recordings. Although offspring mice displayed a significantly reduced body weight at birth, their weights recovered three days after birth. Enhancement of electroencephalogram (EEG slow wave activity (SWA during non-rapid eye movement (NREM sleep was observed in the DR mice over a 24-hour period without changing the diurnal pattern or amounts of wake, NREM, or rapid eye movement (REM sleep. In addition, DR mice also displayed an enhancement of EEG-SWA rebound after a 6-hour sleep deprivation and a higher threshold for waking in the face of external stimuli. DR adult offspring mice exhibited small but significant increases in the expression of hypothalamic peroxisome proliferator-activated receptor α (Pparα and brain-specific carnitine palmitoyltransferase 1 (Cpt1c mRNA, two genes involved in lipid metabolism. Undernutrition during pregnancy may influence sleep homeostasis, with offspring exhibiting greater sleep pressure.

  1. Blood Flow Restricted Exercise and Vascular Function

    Masahiro Horiuchi


    Full Text Available It is established that regular aerobic training improves vascular function, for example, endothelium-dependent vasodilatation and arterial stiffness or compliance and thereby constitutes a preventative measure against cardiovascular disease. In contrast, high-intensity resistance training impairs vascular function, while the influence of moderate-intensity resistance training on vascular function is still controversial. However, aerobic training is insufficient to inhibit loss in muscular strength with advancing age; thus, resistance training is recommended to prevent sarcopenia. Recently, several lines of study have provided compelling data showing that exercise and training with blood flow restriction (BFR leads to muscle hypertrophy and strength increase. As such, BFR training might be a novel means of overcoming the contradiction between aerobic and high-intensity resistance training. Although it is not enough evidence to obtain consensus about impact of BFR training on vascular function, available evidences suggested that BFR training did not change coagulation factors and arterial compliance though with inconsistence results in endothelial function. This paper is a review of the literature on the impact of BFR exercise and training on vascular function, such as endothelial function, arterial compliance, or other potential factors in comparison with those of aerobic and resistance training.

  2. Intrauterine Growth Restriction: Antenatal and Postnatal Aspects

    Sharma, Deepak; Shastri, Sweta; Sharma, Pradeep


    Intrauterine growth restriction (IUGR), a condition that occurs due to various reasons, is an important cause of fetal and neonatal morbidity and mortality. It has been defined as a rate of fetal growth that is less than normal in light of the growth potential of that specific infant. Usually, IUGR and small for gestational age (SGA) are used interchangeably in literature, even though there exist minute differences between them. SGA has been defined as having birth weight less than two standard deviations below the mean or less than the 10th percentile of a population-specific birth weight for specific gestational age. These infants have many acute neonatal problems that include perinatal asphyxia, hypothermia, hypoglycemia, and polycythemia. The likely long-term complications that are prone to develop when IUGR infants grow up includes growth retardation, major and subtle neurodevelopmental handicaps, and developmental origin of health and disease. In this review, we have covered various antenatal and postnatal aspects of IUGR. PMID:27441006

  3. Earth system multi-body restriction dynamics model research

    ZHANG; Qingxian; BI; Siwen; GONG; Huili


    Research provides a theoretical basis for an Earth system multi-body mechanics model and its dynamics, including the Earth system multi-body restriction function and its power, Earth system multi-body restriction under decreasing generalized velocity and decreasing partial palstance, the Earth system multi-body decreasing generalized force, a moving mechanics function, and the Earth system multi-body restriction's wattful and wattless forces.

  4. Maternal Nutrient Restriction Predisposes Ventricular Remodeling in Adult Sheep Offspring

    Ge, Wei; Hu, Nan; George, Lindsey A; Ford, Stephen P.; Peter W Nathanielsz; Wang, Xiaoming; Ren, Jun


    Maternal nutrient restriction during pregnancy is associated with the development of a “thrifty phenotype” in offspring, conferring increased prevalence of metabolic diseases in adulthood. To explore the possible mechanisms behind heart diseases in adulthood following maternal nutrient restriction, dams were fed a nutrient restricted (NR: 50%) or control (100%) diet from 28 to 78 d of gestation. Both groups were then fed 100% of requirements to lambing. At 6 yrs of age, female offspring of NR...

  5. Type I restriction endonucleases are true catalytic enzymes.

    Bianco, Piero R; Xu, Cuiling; Chi, Min


    Type I restriction endonucleases are intriguing, multifunctional complexes that restrict DNA randomly, at sites distant from the target sequence. Restriction at distant sites is facilitated by ATP hydrolysis-dependent, translocation of double-stranded DNA towards the stationary enzyme bound at the recognition sequence. Following restriction, the enzymes are thought to remain associated with the DNA at the target site, hydrolyzing copious amounts of ATP. As a result, for the past 35 years type I restriction endonucleases could only be loosely classified as enzymes since they functioned stoichiometrically relative to DNA. To further understand enzyme mechanism, a detailed analysis of DNA cleavage by the EcoR124I holoenzyme was done. We demonstrate for the first time that type I restriction endonucleases are not stoichiometric but are instead catalytic with respect to DNA. Further, the mechanism involves formation of a dimer of holoenzymes, with each monomer bound to a target sequence and, following cleavage, each dissociates in an intact form to bind and restrict subsequent DNA molecules. Therefore, type I restriction endonucleases, like their type II counterparts, are true enzymes. The conclusion that type I restriction enzymes are catalytic relative to DNA has important implications for the in vivo function of these previously enigmatic enzymes.

  6. Perceived Benefits of Fisheries Management Restrictions in Madagascar

    Tim R. McClanahan


    Full Text Available Perceptions of the benefits of fisheries management restrictions were evaluated in coastal Madagascar to identify restrictions that are likely to be self- and community enforced. The survey focused on 24 Malagasy fishing villages adjacent to coral reefs. Resource users' perceptions of the benefits of restrictions were generally high and widespread, but some less positive perceptions were found in three villages located near marine protected areas. Perceptions of the benefits of gear restrictions had widespread support; closed areas, seasons, and minimum sizes of fish were less common; and restrictions on species were supported infrequently. We therefore advocate a management implementation approach that uses these scales of perceived benefits and prioritizes support for the most widely accepted restrictions most broadly, with the less accepted restrictions matched to specific supportive locations. At the village level, socioeconomic and wealth variables were not clearly associated with perceived benefits, which we suggest results from a stronger influence of village history than socioeconomic conditions. At the individual fisher level, however, there was evidence that experienced people involved in decision-making, having livelihood alternatives, and having permanent housing had more opinions and frequently were more supportive of management restrictions. Incorporating this information into forums and management plans is expected to increase the rate of adoption and compliance with needed fisheries restrictions.

  7. Comparison of a Restricted and Unrestricted Vegan Diet Plan with a Restricted Omnivorous Diet Plan on Health-Specific Measures

    Richard J. Bloomer; Gunnels, Trint A; Schriefer, JohnHenry M.


    Background: We have previously noted beneficial health outcomes when individuals follow a dietary restriction plan in accordance with the Daniel Fast (DF). This is true whether individuals eliminate all animal products or include small amounts of meat and dairy in their plan. The present study sought to compare anthropometric and biochemical measures of health in individuals following a traditional DF (i.e., restricted vegan) or modified DF (i.e., restricted omnivorous; inclusive of ad libitu...

  8. Crowding during restricted and free viewing.

    Wallace, Julian M; Chiu, Michael K; Nandy, Anirvan S; Tjan, Bosco S


    Crowding impairs the perception of form in peripheral vision. It is likely to be a key limiting factor of form vision in patients without central vision. Crowding has been extensively studied in normally sighted individuals, typically with a stimulus duration of a few hundred milliseconds to avoid eye movements. These restricted testing conditions do not reflect the natural behavior of a patient with central field loss. Could unlimited stimulus duration and unrestricted eye movements change the properties of crowding in any fundamental way? We studied letter identification in the peripheral vision of normally sighted observers in three conditions: (i) a fixation condition with a brief stimulus presentation of 250 ms, (ii) another fixation condition but with an unlimited viewing time, and (iii) an unrestricted eye movement condition with an artificial central scotoma and an unlimited viewing time. In all conditions, contrast thresholds were measured as a function of target-to-flanker spacing, from which we estimated the spatial extent of crowding in terms of critical spacing. We found that presentation duration beyond 250 ms had little effect on critical spacing with stable gaze. With unrestricted eye movements and a simulated central scotoma, we found a large variability in critical spacing across observers, but more importantly, the variability in critical spacing was well correlated with the variability in target eccentricity. Our results assure that the large body of findings on crowding made with briefly presented stimuli remains relevant to conditions where viewing time is unconstrained. Our results further suggest that impaired oculomotor control associated with central vision loss can confound peripheral form vision beyond the limits imposed by crowding.

  9. Parental factors associated with intrauterine growth restriction

    Hăşmăşanu Monica G.


    Full Text Available Introduction. Linear growth failure is caused by multiple factors including parental factors. Objective. The aim of this study was to evaluate parental risk factors for intrauterine growth restriction (IUGR on a population of Romanian newborn infants in a tertiary level maternity facility for a period of 2.5 years. Methods. A retrospective matched case-control study was conducted in the Emergency County Hospital of Cluj-Napoca, a university hospital in North-Western Romania. The sample was selected from 4,790 infants admitted to the Neonatal Ward at 1st Gynecology Clinic between January 2012 and June 2014. Results. The age of mothers was significantly lower in the IUGR group compared to controls (p=0.041. A significantly higher percentage of mothers had hypertension in the IUGR group compared to those in the control group (p0.13. The age of fathers of infants with IUGR proved significantly lower compared to controls (p=0.0278. The analysis of infants’ comorbidities revealed no significant difference between groups for respiratory distress, hyperbilirubinemia, hypocalcaemia, and heart failure (p>0.27. Intracranial hemorrhage, necrotizing enterocolitis and hypoglycemia were significantly higher in the IUGR group compared to controls. The logistic regression identified hypertension as a significant risk factor for IUGR (OR=2.4, 95% CI [1.3-4.5]. Conclusion. Although the age of the mothers and fathers proved significantly lower in the IUGR group compared to controls, only hypertension in the mothers proved significant risk factors for IUGR.

  10. 7 CFR 982.452 - Disposition of restricted hazelnuts.


    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Disposition of restricted hazelnuts. 982.452 Section... SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE HAZELNUTS... hazelnuts. (a) Shelling. (1) Any person desiring to shell restricted hazelnuts during a fiscal year may...

  11. 7 CFR 982.52 - Disposition of restricted hazelnuts.


    ... 7 Agriculture 8 2010-01-01 2010-01-01 false Disposition of restricted hazelnuts. 982.52 Section... SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE HAZELNUTS... restricted hazelnuts. Hazelnuts withheld from handling as inshell hazelnuts pursuant to §§ 982.50 and...

  12. The contact geometry of the restricted 3-body problem

    Albers, Peter; van Koert, Otto; Paternain, Gabriel P


    We show that the planar circular restricted three body problem is of restricted contact type for all energies below the first critical value (action of the first Lagrange point) and for energies slightly above it. This opens up the possibility of using the technology of Contact Topology to understand this particular dynamical system.

  13. Restrictions in Availability of Drugs Used for Suicide

    Nordentoft, Merete


    Availability of drugs with high lethality has been hypothesized to increase the risk of self-poisoning suicides. A literature search concerning deliberate self-poisoning and the effect of restricting access to drugs was conducted, and the effect of restrictions in availability of barbiturates, tr...

  14. 7 CFR 2200.10 - Restrictions on lobbying.


    ... 7 Agriculture 15 2010-01-01 2010-01-01 false Restrictions on lobbying. 2200.10 Section 2200.10 Agriculture Regulations of the Department of Agriculture (Continued) LOCAL TELEVISION LOAN GUARANTEE BOARD... Restrictions on lobbying. (a) No funds received through a Loan guaranteed under this Program in this...

  15. 7 CFR 1726.17 - Restrictions on lobbying.


    ... 7 Agriculture 11 2010-01-01 2010-01-01 false Restrictions on lobbying. 1726.17 Section 1726.17 Agriculture Regulations of the Department of Agriculture (Continued) RURAL UTILITIES SERVICE, DEPARTMENT OF AGRICULTURE ELECTRIC SYSTEM CONSTRUCTION POLICIES AND PROCEDURES General § 1726.17 Restrictions on...

  16. 7 CFR 761.5 - Restrictions on lobbying.


    ... 7 Agriculture 7 2010-01-01 2010-01-01 false Restrictions on lobbying. 761.5 Section 761.5... lobbying. A person who applies for or receives a loan made or guaranteed by the Agency must comply with the restrictions on lobbying in 7 CFR part 3018....

  17. 13 CFR 400.108 - Restrictions on lobbying.


    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Restrictions on lobbying. 400.108 Section 400.108 Business Credit and Assistance EMERGENCY STEEL GUARANTEE LOAN BOARD EMERGENCY STEEL GUARANTEE LOAN PROGRAM Board Procedures § 400.108 Restrictions on lobbying. (a) No funds received through...

  18. 7 CFR 1944.657 - Restrictions on lobbying.


    ... 7 Agriculture 13 2010-01-01 2009-01-01 true Restrictions on lobbying. 1944.657 Section 1944.657...) PROGRAM REGULATIONS (CONTINUED) HOUSING Housing Preservation Grants § 1944.657 Restrictions on lobbying... funds for lobbying the Federal Government in connection with a specific grant....

  19. 13 CFR 500.108 - Restrictions on lobbying.


    ... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Restrictions on lobbying. 500.108 Section 500.108 Business Credit and Assistance EMERGENCY OIL AND GAS GUARANTEED LOAN BOARD EMERGENCY OIL AND GAS GUARANTEED LOAN PROGRAM Board Procedures § 500.108 Restrictions on lobbying. (a) No...

  20. Synthesis of conformationally restricted beta-turn mimics

    IJsselstijn, Maarten


    This thesis aims at developing methods for introducing conformational restriction in Beta-turns, the turn elements present in Beta-sheets. A conformationally restricted peptide might either be formed via incorporation of a bridging diamino acids in a growing peptide chain, or via covalent bond formi

  1. 24 CFR 200.72 - Zoning, deed and building restrictions.


    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Zoning, deed and building restrictions. 200.72 Section 200.72 Housing and Urban Development Regulations Relating to Housing and Urban... Zoning, deed and building restrictions. The project when completed shall not violate any material...

  2. 24 CFR 242.78 - Zoning, deed, and building restrictions.


    ... 24 Housing and Urban Development 2 2010-04-01 2010-04-01 false Zoning, deed, and building... AUTHORITIES MORTGAGE INSURANCE FOR HOSPITALS Miscellaneous Requirements § 242.78 Zoning, deed, and building restrictions. The project when completed shall not violate any material zoning or deed restrictions...

  3. The challenge of cost restrictions in smile design.

    Feigenbaum, N


    This article demonstrates a method for smile enhancement involving the familiar "gummy" smile as well as irregular incisor gingival emergence levels. In this case study, financial considerations limited a comprehensive restorative treatment plan, restricting changes to several anterior teeth. Despite the restrictions, a solution was found.

  4. Restriction digestion method for haplotyping the potato psyllid, Bactericera cockerelli

    A restriction digestion method has been developed for haplotyping the potato psyllid, Bactericera cockerelli Sulc., an economically important pest of solanaceous crops. This method differentiates the four known potato psyllid haplotypes by utilizing restriction enzyme digestion of a portion of the ...

  5. 50 CFR 640.22 - Gear and diving restrictions.


    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Gear and diving restrictions. 640.22 Section 640.22 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND... ATLANTIC Management Measures § 640.22 Gear and diving restrictions. (a) Prohibited gear and methods. (1)...

  6. On some Frobenius Restriction Theorems for Semistable Sheaves

    V B Mehta; V Trivedi


    We prove a version of an effective Frobenius restriction theorem for semistable bundles in characteristic . The main novelty is in restricting the bundle to the -fold thickening of a hypersurface section. The base variety is /, an abelian variety or a smooth projective toric variety.

  7. Proteasomal degradation of TRIM5alpha during retrovirus restriction.

    Christopher James Rold


    Full Text Available The host protein TRIM5alpha inhibits retroviral infection at an early post-penetration stage by targeting the incoming viral capsid. While the detailed mechanism of restriction remains unclear, recent studies have implicated the activity of cellular proteasomes in the restriction of retroviral reverse transcription imposed by TRIM5alpha. Here, we show that TRIM5alpha is rapidly degraded upon encounter of a restriction-susceptible retroviral core. Inoculation of TRIM5alpha-expressing human 293T cells with a saturating level of HIV-1 particles resulted in accelerated degradation of the HIV-1-restrictive rhesus macaque TRIM5alpha protein but not the nonrestrictive human TRIM5alpha protein. Exposure of cells to HIV-1 also destabilized the owl monkey restriction factor TRIMCyp; this was prevented by addition of the inhibitor cyclosporin A and was not observed with an HIV-1 virus containing a mutation in the capsid protein that relieves restriction by TRIMCyp IVHIV. Likewise, human TRIM5alpha was rapidly degraded upon encounter of the restriction-sensitive N-tropic murine leukemia virus (N-MLV but not the unrestricted B-MLV. Pretreatment of cells with proteasome inhibitors prevented the HIV-1-induced loss of both rhesus macaque TRIM5alpha and TRIMCyp proteins. We also detected degradation of endogenous TRIM5alpha in rhesus macaque cells following HIV-1 infection. We conclude that engagement of a restriction-sensitive retrovirus core results in TRIM5alpha degradation by a proteasome-dependent mechanism.

  8. Reverse triple I method of restriction for fuzzy reasoning


    A theory of reverse triple I method of restriction for implication operator R0 is proposed.And the general computation formulas of infimum for fuzzy modus ponens and supremum for fuzzy modus tollens of a-reverse triple I method of restriction are obtained respectively.

  9. Reduced Automatic Motivational Orientation Towards Food in Restricting Anorexia Nervosa

    Veenstra, Esther M.; de Jong, Peter J.


    A striking and characteristic feature of the restricting subtype of anorexia nervosa (AN) is that they are extremely successful in regulating their food intake in a destructive manner. A possible explanation for the persistent character of their restricted food intake could be a loss of the motivati

  10. Consequences of intrauterine growth restriction for the kidney

    M.F. Schreuder; A. van Wijk (Ans); H.A. Delemarre-van de Waal (Henriette)


    textabstractLow birth weight due to intrauterine growth restriction is associated with various diseases in adulthood, such as hypertension, cardiovascular disease, insulin resistance and end-stage renal disease. The purpose of this review is to describe the effects of intrauterine growth restriction

  11. Acute sleep restriction reduces insulin sensitivity in adolescent boys

    Klingenberg, Lars; Chaput, Jean-Philippe; Holmbäck, Ulf;


    Short sleep duration has been linked to impaired glucose metabolism in many experimental studies. Moreover, studies have reported indications of an increased metabolic stress following sleep restriction.......Short sleep duration has been linked to impaired glucose metabolism in many experimental studies. Moreover, studies have reported indications of an increased metabolic stress following sleep restriction....

  12. 5 CFR 295.207 - Restrictions that apply to testimony.


    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Restrictions that apply to testimony. 295.207 Section 295.207 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT CIVIL SERVICE REGULATIONS... PROCEEDINGS Requests for Testimony and Production of Documents § 295.207 Restrictions that apply to...

  13. Study on interest rate restrictions (IRR): Belgian national report

    Vannerom, J.; Terryn, E.


    DG Internal Market and Services of the European Commission have commissioned us to conduct a study on interest rate restrictions in consumer credit covering unsecured and secured credit (i.e. including mortgage credit). This project aims to identify the different types of interest rate restrictions

  14. 50 CFR 665.127 - Allowable gear and gear restrictions.


    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Allowable gear and gear restrictions. 665... Fisheries § 665.127 Allowable gear and gear restrictions. (a) American Samoa coral reef ecosystem MUS may be taken only with the following allowable gear and methods: (1) Hand harvest; (2) Spear; (3) Slurp gun;...

  15. 50 CFR 665.427 - Allowable gear and gear restrictions.


    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Allowable gear and gear restrictions. 665... Archipelago Fisheries § 665.427 Allowable gear and gear restrictions. (a) Mariana coral reef ecosystem MUS may be taken only with the following allowable gear and methods: (1) Hand harvest; (2) Spear; (3)...

  16. 50 CFR 665.227 - Allowable gear and gear restrictions.


    ... 50 Wildlife and Fisheries 9 2010-10-01 2010-10-01 false Allowable gear and gear restrictions. 665... Fisheries § 665.227 Allowable gear and gear restrictions. (a) Hawaii coral reef ecosystem MUS may be taken only with the following allowable gear and methods: (1) Hand harvest; (2) Spear; (3) Slurp gun;...

  17. 32 CFR 228.15 - Restriction regarding animals.


    ... 32 National Defense 2 2010-07-01 2010-07-01 false Restriction regarding animals. 228.15 Section 228.15 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS SECURITY PROTECTIVE FORCE § 228.15 Restriction regarding animals. No animals...

  18. 32 CFR 234.12 - Restriction on animals.


    ... 32 National Defense 2 2010-07-01 2010-07-01 false Restriction on animals. 234.12 Section 234.12 National Defense Department of Defense (Continued) OFFICE OF THE SECRETARY OF DEFENSE (CONTINUED) MISCELLANEOUS CONDUCT ON THE PENTAGON RESERVATION § 234.12 Restriction on animals. Animals, except guide...

  19. 75 FR 61612 - Airports/Locations: Special Operating Restrictions


    ... . SUPPLEMENTARY INFORMATION: Background On November 30, 1999 (64 FR 66768), the FAA... Federal Aviation Administration 14 CFR Part 91 Airports/Locations: Special Operating Restrictions AGENCY... amending its airports and locations special operating restrictions regulation to clarify a...

  20. Supporting several levels of restriction in the UML

    Hansen, Klaus Marius; Damm, Christian Heide; Thomsen, Michael;


    The emergence of the Unified Modeling Language (UML) has provided software developers with an effective and efficient shared language. However, UML is often too restrictive in initial, informal, and creative modelling, and it is in some cases not restrictive enough, e.g., for code generation. Bas...

  1. 49 CFR 236.813a - State, most restrictive.


    ... 49 Transportation 4 2010-10-01 2010-10-01 false State, most restrictive. 236.813a Section 236.813a Transportation Other Regulations Relating to Transportation (Continued) FEDERAL RAILROAD ADMINISTRATION... State, most restrictive. The mode of an electric or electronic device that is equivalent to a...

  2. 40 CFR 152.168 - Advertising of restricted use products.


    ... advertised unless the advertisement contains a statement of its restricted use classification. (b) The... advertisement. The requirement may be satisfied with respect to broadcast or telephone advertising by inclusion... 40 Protection of Environment 23 2010-07-01 2010-07-01 false Advertising of restricted use...

  3. 48 CFR 1403.570 - Restrictions on contractor advertising.


    ... 48 Federal Acquisition Regulations System 5 2010-10-01 2010-10-01 false Restrictions on contractor advertising. 1403.570 Section 1403.570 Federal Acquisition Regulations System DEPARTMENT OF THE INTERIOR... 1403.570 Restrictions on contractor advertising....

  4. Semiparametric regression for restricted mean residual life under right censoring

    Mansourvar, Zahra; Martinussen, Torben; Scheike, Thomas H.


    is not observed, the restricted mean residual life must be considered. In this paper, we propose the proportional restricted mean residual life model for fitting survival data under right censoring. For inference on the model parameters, martingale estimating equations are developed, and the asymptotic properties...

  5. Constructing Restricted Patterson Measures for Geometrically Infinite Kleinian Groups

    Kurt FALK; Bernd O. STRATMANN


    In this paper, we study exhaustions, referred to as ρ-restrictions, of arbitrary nonelementary Kleinian groups with at most finitely many bounded parabolic elements. Special emphasis is put on the geometrically infinite case, where we obtain that the limit set of each of these Kleinian groups contains an infinite family of closed subsets, referred to as ρ-restricted limit sets, such that there in this family. Generalizing concepts which are well known in the geometrically finite case, we then introduce the notion of ρ-restricted Patterson measure, and show that these measures are non-atomic,δρ-harmonic, δρ-subconformal on special sets and δρ-conformal on very special sets. Furthermore, we obtain the results that each ρ-restriction of our Kleinian group is of δρ-divergence type and that the Hausdorff dimension of the ρ-restricted limit set is equal to δρ.

  6. Recommendations of activity restriction in high-risk pregnancy scenarios

    Bendix, Jane; Hegaard, Hanne Kristine; Bergholt, Thomas;


    obstetricians and midwives prescribe activity restriction in most high-risk pregnancies. The degree of activity restriction and the presumed effect vary between clinicians. This may reflect different attitudes and lack of guidelines based on clinical studies of a possible benefit of activity restriction....... to the obstetricians, the midwives also reported that they expected the recommendation to be more effective. Most midwives and obstetricians reported that they thought strict activity restriction was associated with severe or moderate adverse effect, and recommended antithrombotic prophylaxis. Conclusions: Danish......Abstract Aims: To describe specific recommendations of activity restriction, place of care, expected beneficial and adverse effects, and recommended antithrombotic prophylaxis in nine clinical scenarios. Methods: A national survey. All members of the Danish Society of Obstetrics and Gynaecology...

  7. Restriction enzyme cutting site distribution regularity for DNA looping technology.

    Shang, Ying; Zhang, Nan; Zhu, Pengyu; Luo, Yunbo; Huang, Kunlun; Tian, Wenying; Xu, Wentao


    The restriction enzyme cutting site distribution regularity and looping conditions were studied systematically. We obtained the restriction enzyme cutting site distributions of 13 commonly used restriction enzymes in 5 model organism genomes through two novel self-compiled software programs. All of the average distances between two adjacent restriction sites fell sharply with increasing statistic intervals, and most fragments were 0-499 bp. A shorter DNA fragment resulted in a lower looping rate, which was also directly proportional to the DNA concentration. When the length was more than 500 bp, the concentration did not affect the looping rate. Therefore, the best known fragment length was longer than 500 bp, and did not contain the restriction enzyme cutting sites which would be used for digestion. In order to make the looping efficiencies reach nearly 100%, 4-5 single cohesive end systems were recommended to digest the genome separately.

  8. Quadratic Loss of Isotonic Normal Means Under Simultaneous Order Restrictions

    马艳萍; 史宁中


    For two normal populations with unknown means μ and unknown variances σ2,assume that there are simple order restrictions among the means and variances:μ1≤μ2 and σ12≥σ22>0,This case is said to be simultaneous order restriction by Shi (Maximum likelihood estimation of means and variances from normal populations under simultaneous order restrictions.J.Multivariate,Anal.50(1994),282-293.)and an iterative algorithm of computing the order restricted maximum likelihood estimates of μi and σi2 was given in that paper,This paper shows that the restricted maximum likelihood estimate of μi has smaller mean square loss than the usual estimate xi under some conditions.

  9. Controlling pandemic flu: the value of international air travel restrictions.

    Joshua M Epstein

    Full Text Available BACKGROUND: Planning for a possible influenza pandemic is an extremely high priority, as social and economic effects of an unmitigated pandemic would be devastating. Mathematical models can be used to explore different scenarios and provide insight into potential costs, benefits, and effectiveness of prevention and control strategies under consideration. METHODS AND FINDINGS: A stochastic, equation-based epidemic model is used to study global transmission of pandemic flu, including the effects of travel restrictions and vaccination. Economic costs of intervention are also considered. The distribution of First Passage Times (FPT to the United States and the numbers of infected persons in metropolitan areas worldwide are studied assuming various times and locations of the initial outbreak. International air travel restrictions alone provide a small delay in FPT to the U.S. When other containment measures are applied at the source in conjunction with travel restrictions, delays could be much longer. If in addition, control measures are instituted worldwide, there is a significant reduction in cases worldwide and specifically in the U.S. However, if travel restrictions are not combined with other measures, local epidemic severity may increase, because restriction-induced delays can push local outbreaks into high epidemic season. The per annum cost to the U.S. economy of international and major domestic air passenger travel restrictions is minimal: on the order of 0.8% of Gross National Product. CONCLUSIONS: International air travel restrictions may provide a small but important delay in the spread of a pandemic, especially if other disease control measures are implemented during the afforded time. However, if other measures are not instituted, delays may worsen regional epidemics by pushing the outbreak into high epidemic season. This important interaction between policy and seasonality is only evident with a global-scale model. Since the benefit of

  10. HIV-related travel restrictions: trends and country characteristics

    Felicia Chang


    Full Text Available Introduction: Increasingly, HIV-seropositive individuals cross international borders. HIV-related restrictions on entry, stay, and residence imposed by countries have important consequences for this mobile population. Our aim was to describe the geographical distribution of countries with travel restrictions and to examine the trends and characteristics of countries with such restrictions. Methods: In 2011, data presented to UNAIDS were used to establish a list of countries with and without HIV restrictions on entry, stay, and residence and to describe their geographical distribution. The following indicators were investigated to describe the country characteristics: population at mid-year, international migrants as a percentage of the population, Human Development Index, estimated HIV prevalence (age: 15–49, presence of a policy prohibiting HIV screening for general employment purposes, government and civil society responses to having non-discrimination laws/regulations which specify migrants/mobile populations, government and civil society responses to having laws/regulations/policies that present obstacles to effective HIV prevention, treatment, care, and support for migrants/mobile populations, Corruption Perception Index, and gross national income per capita. Results: HIV-related restrictions exist in 45 out of 193 WHO countries (23% in all regions of the world. We found that the Eastern Mediterranean and Western Pacific Regions have the highest proportions of countries with these restrictions. Our analyses showed that countries that have opted for restrictions have the following characteristics: smaller populations, higher proportions of migrants in the population, lower HIV prevalence rates, and lack of legislation protecting people living with HIV from screening for employment purposes, compared with countries without restrictions. Conclusion: Countries with a high proportion of international migrants tend to have travel restrictions

  11. Company Law as a Restriction to Free Movement

    Sørensen, Karsten Engsig


    Focusing on recent judgments from the Court of Justice of the European Union, this article investigates how the notion of ‘restriction’ – which is the first step in examining whether there is an infringement of the free movement rights – is used in cases involving company law measures....... There is evidence that non-discriminatory obstacles to free movement found in company law can be restrictions. However, recent cases show that the Court may be willing to apply a more restrictive approach where only non-discriminatory measures that have a qualified deterrent effect may constitute restrictions....

  12. Predicting support for restricting food marketing to youth.

    Goren, Amir; Harris, Jennifer L; Schwartz, Marlene B; Brownell, Kelly D


    To address the obesity crisis, public health experts recommend major reductions in the marketing of unhealthy food to youth. However, policies to restrict food marketing are not currently viewed as politically feasible. This paper examines attitudes and knowledge about food marketing and support for restricting unhealthy food marketing [corrected] among one group of constituents: parents. A survey of 807 parents found that those most likely to support food marketing restrictions were also more likely to have negative views of current food practices. [corrected] These findings suggest that increased public education about the harm caused by food marketing may increase public support for policy interventions.

  13. Intracerebral metastasis showing restricted diffusion: Correlation with histopathologic findings

    Duygulu, G. [Radiology Department, Ege University Medicine School, Izmir (Turkey); Ovali, G. Yilmaz [Radiology Department, Celal Bayar University Medicine School, Manisa (Turkey)], E-mail:; Calli, C.; Kitis, O.; Yuenten, N. [Radiology Department, Ege University Medicine School, Izmir (Turkey); Akalin, T. [Pathology Department, Ege University Medicine School, Izmir (Turkey); Islekel, S. [Neurosurgery Department, Ege University Medicine School, Izmir (Turkey)


    Objective: We aimed to detect the frequency of restricted diffusion in intracerebral metastases and to find whether there is correlation between the primary tumor pathology and diffusion-weighted MR imaging (DWI) findings of these metastases. Material and methods: 87 patients with intracerebral metastases were examined with routine MR imaging and DWI. 11 hemorrhagic metastatic lesions were excluded. The routine MR imaging included three plans before and after contrast enhancement. The DWI was performed with spin-echo EPI sequence with three b values (0, 500 and 1000), and ADC maps were calculated. 76 patients with metastases were grouped according to primary tumor histology and the ratios of restricted diffusion were calculated according to these groups. ADCmin values were measured within the solid components of the tumors and the ratio of metastases with restricted diffusion to that which do not show restricted diffusion were calculated. Fisher's exact and Mann-Whitney U tests were used for the statistical analysis. Results: Restricted diffusion was observed in a total of 15 metastatic lesions (19, 7%). Primary malignancy was lung carcinoma in 10 of these cases (66, 6%) (5 small cell carcinoma, 5 non-small cell carcinoma), and breast carcinoma in three cases (20%). Colon carcinoma and testicular teratocarcinoma were the other two primary tumors in which restricted diffusion in metastasis was detected. There was no statistical significant difference between the primary pathology groups which showed restricted diffusion (p > 0.05). ADCmin values of solid components of the metastasis with restricted diffusion and other metastasis without restricted diffusion also showed no significant statistical difference (0.72 {+-} 0.16 x 10{sup -3} mm{sup 2}/s and 0.78 {+-} 21 x 10{sup -3} mm{sup 2}/s respectively) (p = 0.325). Conclusion: Detection of restricted diffusion on DWI in intracerebral metastasis is not rare, particularly if the primary tumor is lung or breast

  14. Chances and restrictions for farms situated on areas with environmental restrictions - data from Polish FADN

    Grażyna Niewęgłowska


    Full Text Available Due to the higher environmental biodiversity of Poland in comparison to Europe and due of fact that 32.5% share of all areas are protected by Polish nature protection law – it is very important to make an analyis about managing on these areas. There are a lot of restrictions in the Polish nature protection law. Farm owners are obliged to manage their farms due to Polish nature protection law. Farmers operating on that areas ought to play double role on agrarian market. They are producers of Polish food with high quality first and they are managers of Polish landscape and biodiversity – second. Because of that there is a very important thing to find out how they manage the environmental in protected areas. Data source for this issue was Polish FADN. There are very interesting results from this issue but they are only the first data because they are from one year.

  15. Restricted Quantum Affine Symmetry of Perturbed Minimal Models

    Felder, G


    We study the structure of superselection sectors of an arbitrary perturbation of a conformal field theory. We describe how a restriction of the q-deformed $\\hat{sl(2)}$ affine Lie algebra symmetry of the sine-Gordon theory can be used to derive the S-matrices of the $\\Phi^{(1,3)}$ perturbations of the minimal unitary series. This analysis provides an identification of fields which create the massive kink spectrum. We investigate the ultraviolet limit of the restricted sine-Gordon model, and explain the relation between the restriction and the Fock space cohomology of minimal models. We also comment on the structure of degenerate vacuum states. Deformed Serre relations are proven for arbitrary affine Toda theories, and it is shown in certain cases how relations of the Serre type become fractional spin supersymmetry relations upon restriction.

  16. 7 CFR 930.63 - Deferment of restricted obligation.


    ... SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE TART CHERRIES GROWN IN THE STATES OF MICHIGAN, NEW YORK, PENNSYLVANIA, OREGON, UTAH, WASHINGTON, AND WISCONSIN... regulations issued thereunder, secure bonds on restricted percentage cherries to temporarily defer the...

  17. Restricted Access Federal Lands in Western North America

    U.S. Geological Survey, Department of the Interior — This data set depicts federal lands having restrictions on access or activities -- that is, lands mangaed by the National Park Service, Defense Department, or Energy...

  18. Total sleep deprivation, chronic sleep restriction and sleep disruption.

    Reynolds, Amy C; Banks, Siobhan


    Sleep loss may result from total sleep deprivation (such as a shift worker might experience), chronic sleep restriction (due to work, medical conditions or lifestyle) or sleep disruption (which is common in sleep disorders such as sleep apnea or restless legs syndrome). Total sleep deprivation has been widely researched, and its effects have been well described. Chronic sleep restriction and sleep disruption (also known as sleep fragmentation) have received less experimental attention. Recently, there has been increasing interest in sleep restriction and disruption as it has been recognized that they have a similar impact on cognitive functioning as a period of total sleep deprivation. Sleep loss causes impairments in cognitive performance and simulated driving and induces sleepiness, fatigue and mood changes. This review examines recent research on the effects of sleep deprivation, restriction and disruption on cognition and neurophysiologic functioning in healthy adults, and contrasts the similarities and differences between these three modalities of sleep loss.

  19. HCUP State Emergency Department Databases (SEDD) - Restricted Access File

    U.S. Department of Health & Human Services — The State Emergency Department Databases (SEDD) contain the universe of emergency department visits in participating States. Restricted access data files are...

  20. 3-restricted connectivity of graphs with given girth

    GUO Li-tao; MENG Ji-xiang


    Let G = (V, E) be a connected graph. X C V(G) is a vertex set. X is a 3-restricted cut of G, if G-X is not connected and every component of G-X has at least three vertices. The 3-restricted connectivity k3(G) (in short k3) of G is the cardinality of a minimum 3-restricted cut of G. Χ is called κ3-cut, if Χ = κ3. A graph G is κa-connected, if a 3-restricted cut exists.Let G be a graph girth g ≥ 4, ξ3(G) is min{d(χ) + d(у) + d(z) - 4 : χуz is a 2-path of G}. It will be shown that κ3(G) = ξ3(G) under the condition of girth.

  1. 45 CFR 1226.10 - Hatch Act restrictions.


    ... office as a precinct or ward leader or representative, or service on any committee of a political party... for nomination or election to a National, State, or local office. (b) Hatch Act restrictions apply...

  2. Risk Factors for Restricting Back Pain in Older Persons

    Makris, Una E.; Fraenkel, Liana; Han, Ling; Leo-Summers, Linda; Gill, Thomas M.


    Objectives To identify risk factors for back pain leading to restricted activity (restricting back pain) in older persons. Design Prospective cohort study. Setting Greater New Haven, Connecticut. Participants 731 men and women aged 70 years or older, who were community-living and non-disabled in essential activities of daily living at baseline. Measurements Candidate risk factors were ascertained every 18 months for 108 months during comprehensive home-based assessments. Restricting back pain was assessed during monthly telephone interviews for up to 126 months. Incident episodes of: (1) short-term (one episode lasting one month) restricting back pain; and (2) persistent (one episode lasting two or more months) or recurrent (two or more episodes of any duration) restricting back pain were determined during each 18-month interval. The associations between the candidate risk factors and short-term and persistent/recurrent restricting back pain, respectively, were evaluated using a multivariable Cox model. Results The cumulative incidence was 21.3% (95% confidence interval (CI) 19.6%, 23.1%) for short-term restricting back pain and 20.6% (CI 18.6%, 22.9%) for persistent/recurrent restricting back pain over a median follow-up of 109 months. In a recurrent event multivariable analysis, female sex (HR 1.30; 1.07, 1.58), weak grip strength (HR 1.24; 1.01,1.52), and hip weakness (HR 1.19; 1.07,1.32) were independently associated with an increased likelihood of having short-term restricting back pain, while female sex (HR 1.48; CI 1.13,1.94), depressive symptoms (HR 1.57; 1.23, 2.00), 2 or more chronic conditions (HR 1.38; 1.08, 1.77), and arthritis (HR1.66; 1.31, 2.09) were independently associated with persistent/recurrent restricting back pain. Conclusion In this prospective study, several factors were independently associated with restricting back pain, including some that may be modifiable and therefore potential targets for interventions to reduce this common and

  3. Defense Acquistion: Rationale for Imposing Domestic Source Restrictions.


    retained the restriction for polyacrylonitrile-based carbon fiber, periscope tube forgings, bull gear ring forgings, and ship propulsion shaft...forgings 1984 Protect sensitive data Ship propulsion shaft forgings 1984 Unsettled conditions among suppliers In its reviews of industrial base... Ship Propulsion Shafts 14 14 15 16 17 Appendix III Rationale for 10 U.S.C. 2534-Imposed Restrictions Buses Chemical Weapons Antidote

  4. IS-linked movement of a restriction-modification system.

    Noriko Takahashi

    Full Text Available Potential mobility of restriction-modification systems has been suggested by evolutionary/bioinformatic analysis of prokaryotic genomes. Here we demonstrate in vivo movement of a restriction-modification system within a genome under a laboratory condition. After blocking replication of a temperature-sensitive plasmid carrying a PaeR7I restriction-modification system in Escherichia coli cells, the plasmid was found integrated into the chromosome of the surviving cells. Sequence analysis revealed that, in the majority of products, the restriction-modification system was linked to chromosomal insertion sequences (ISs. Three types of products were: (I apparent co-integration of the plasmid and the chromosome at a chromosomal IS1 or IS5 copy (24/28 analyzed; (II de novo insertion of IS1 with the entire plasmid except for a 1-3 bp terminal deletion (2/28; and (III reciprocal crossing-over between the plasmid and the chromosome involving 1-3 bp of sequence identity (2/28. An R-negative mutation apparently decreased the efficiency of successful integration by two orders of magnitude. Reconstruction experiments demonstrated that the restriction-dependence was mainly due to selection against cells without proper integration: their growth was inhibited by the restriction enzyme action. These results demonstrate collaboration of a mobile element and a restriction-modification system for successful joint migration. This collaboration may have promoted the spread and, therefore, the long-term persistence of these complexes and restriction-modification systems in a wide range of prokaryotes.

  5. Appetite for reproduction: dietary restriction, aging and the mammalian gonad

    Nalam, Roopa L; Pletcher, Scott D; Matzuk, Martin M


    The major physiologic theory of aging, the disposable soma theory, links dietary restriction (DR), also known as calorie or food restriction, to prolonged lifespan and makes specific predictions about the effects of aging and DR on reproduction. A recent study in BMC Biology profiling the effects of aging and DR on gonadal gene expression provides novel molecular evidence that has a significant impact on this theory of aging. PMID:18828876

  6. Napping Reverses Increased Pain Sensitivity Due to Sleep Restriction

    Brice Faraut; Damien Léger; Terkia Medkour; Alexandre Dubois; Virginie Bayon; Mounir Chennaoui; Serge Perrot


    Study Objective To investigate pain sensitivity after sleep restriction and the restorative effect of napping. Design A strictly controlled randomized crossover study with continuous polysomnography monitoring was performed. Setting Laboratory-based study. Participants 11 healthy male volunteers. Interventions Volunteers attended two three-day sessions: “sleep restriction” alone and “sleep restriction and nap”. Each session involved a baseline night of normal sleep, a night of sleep deprivati...

  7. Reinforcer devaluation by extinction depends on the food restriction protocol.

    Baker, Tyson W; Weisman, Ronald G; Beninger, Richard J


    A common feature of reinforcer devaluation studies is that new learning induces the devaluation. The present study used extinction to induce new learning about the conditioned reinforcer in a heterogeneous chain schedule. Rats pressed a lever in a heterogeneous chain schedule to produce a conditioned reinforcer (light) associated with the opportunity to obtain an unconditioned reinforcer (food) by pulling a chain. The density of food reinforcement correlated with the conditioned reinforcer was varied in a comparison of continuous and variable-ratio reinforcement schedules of chain pulling; this had no noticeable effect on conditioned reinforcer devaluation produced by extinction of chain pulling. In contrast, how rats were deprived appeared to matter very much. Restricting meal duration to 1h daily produced more lever pressing during baseline training and a greater reductive effect of devaluation on lever pressing than restricting body weight to 80% of a control rat's weight, which eliminated the devaluation effect. Further analysis suggested that meal-duration restriction may have produced devaluation effects because it was more effective than weight restriction in reducing rats' body weights. Our results exposed an important limitation on the devaluation of conditioned reinforcers: slight differences in food restriction, using two commonly employed food-restriction procedures, can produce completely different interpretations of reinforcer devaluation while leaving reinforcer-based learning intact.

  8. The other face of restriction: modification-dependent enzymes.

    Loenen, Wil A M; Raleigh, Elisabeth A


    The 1952 observation of host-induced non-hereditary variation in bacteriophages by Salvador Luria and Mary Human led to the discovery in the 1960s of modifying enzymes that glucosylate hydroxymethylcytosine in T-even phages and of genes encoding corresponding host activities that restrict non-glucosylated phage DNA: rglA and rglB (restricts glucoseless phage). In the 1980's, appreciation of the biological scope of these activities was dramatically expanded with the demonstration that plant and animal DNA was also sensitive to restriction in cloning experiments. The rgl genes were renamed mcrA and mcrBC (modified cytosine restriction). The new class of modification-dependent restriction enzymes was named Type IV, as distinct from the familiar modification-blocked Types I-III. A third Escherichia coli enzyme, mrr (modified DNA rejection and restriction) recognizes both methylcytosine and methyladenine. In recent years, the universe of modification-dependent enzymes has expanded greatly. Technical advances allow use of Type IV enzymes to study epigenetic mechanisms in mammals and plants. Type IV enzymes recognize modified DNA with low sequence selectivity and have emerged many times independently during evolution. Here, we review biochemical and structural data on these proteins, the resurgent interest in Type IV enzymes as tools for epigenetic research and the evolutionary pressures on these systems.

  9. Physiogenomic analysis of weight loss induced by dietary carbohydrate restriction

    Wood Richard J


    Full Text Available Abstract Background Diets that restrict carbohydrate (CHO have proven to be a successful dietary treatment of obesity for many people, but the degree of weight loss varies across individuals. The extent to which genetic factors associate with the magnitude of weight loss induced by CHO restriction is unknown. We examined associations among polymorphisms in candidate genes and weight loss in order to understand the physiological factors influencing body weight responses to CHO restriction. Methods We screened for genetic associations with weight loss in 86 healthy adults who were instructed to restrict CHO to a level that induced a small level of ketosis (CHO ~10% of total energy. A total of 27 single nucleotide polymorphisms (SNPs were selected from 15 candidate genes involved in fat digestion/metabolism, intracellular glucose metabolism, lipoprotein remodeling, and appetite regulation. Multiple linear regression was used to rank the SNPs according to probability of association, and the most significant associations were analyzed in greater detail. Results Mean weight loss was 6.4 kg. SNPs in the gastric lipase (LIPF, hepatic glycogen synthase (GYS2, cholesteryl ester transfer protein (CETP and galanin (GAL genes were significantly associated with weight loss. Conclusion A strong association between weight loss induced by dietary CHO restriction and variability in genes regulating fat digestion, hepatic glucose metabolism, intravascular lipoprotein remodeling, and appetite were detected. These discoveries could provide clues to important physiologic adaptations underlying the body mass response to CHO restriction.

  10. Temporary feed restriction partially protects broilers from necrotic enteritis.

    Tsiouris, V; Georgopoulou, I; Batzios, Chr; Pappaioannou, N; Ducatelle, R; Fortomaris, P


    The objective of this study was to investigate the effect of feed restriction on the intestinal ecosystem and on the pathogenesis of experimental necrotic enteritis in broiler chicks. To induce subclinical necrotic enteritis, an experimental challenge model using a specific diet formulation, Gumboro vaccination, oral inoculation of broilers with a 10-fold dose of attenuated anticoccidial vaccine and multiple oral inoculations with a specific strain of Clostridium perfringens was adopted. Two hundred and forty 1-day-old Cobb 500 broilers were randomly allocated to four groups: feed restricted, challenged, both feed restricted and challenged, and negative control. At 21, 22, 23 and 24 days of age, the intestines, gizzard and liver were collected from 15 birds in each group and scored for gross lesions. The intestinal digesta was collected for pH and viscosity determination. One caecum from each bird was taken for microbiological analysis. The application of feed restriction in birds challenged with C. perfringens reduced the necrotic enteritis lesion score significantly (P ≤ 0.05) and feed restriction significantly reduced (P ≤ 0.05) pH in the small intestine, the viscosity of the jejunum digesta as well as the C. perfringens counts in the caeca compared with the controls. In conclusion, feed restriction of broilers has a positive effect on the intestinal ecosystem and a significant protective effect against necrotic enteritis in the subclinical experimental model.

  11. Napping reverses increased pain sensitivity due to sleep restriction.

    Brice Faraut

    Full Text Available To investigate pain sensitivity after sleep restriction and the restorative effect of napping.A strictly controlled randomized crossover study with continuous polysomnography monitoring was performed.Laboratory-based study.11 healthy male volunteers.Volunteers attended two three-day sessions: "sleep restriction" alone and "sleep restriction and nap". Each session involved a baseline night of normal sleep, a night of sleep deprivation and a night of free recovery sleep. Participants were allowed to sleep only from 02:00 to 04:00 during the sleep deprivation night. During the "sleep restriction and nap" session, volunteers took two 30-minute naps, one in the morning and one in the afternoon.Quantitative sensory testing was performed with heat, cold and pressure, at 10:00 and 16:00, on three areas: the supraspinatus, lower back and thigh. After sleep restriction, quantitative sensory testing revealed differential changes in pain stimuli thresholds, but not in thermal threshold detection: lower back heat pain threshold decreased, pressure pain threshold increased in the supraspinatus area and no change was observed for the thigh. Napping restored responses to heat pain stimuli in the lower back and to pressure stimuli in the supraspinatus area.Sleep restriction induces different types of hypersensitivity to pain stimuli in different body areas, consistent with multilevel mechanisms, these changes being reversed by napping. The napping restorative effect on pain thresholds result principally from effects on pain mechanisms, since it was independent of vigilance status.

  12. The Restriction Fragment Map of Rat-Liver Mitochondrial DNA : A Reconsideration

    Pepe, G.; Bakker, H.; Holtrop, M.; Bollen, J.E.; Bruggen, E.F.J. van; Cantatore, P.; Terpstra, P.; Saccone, C.


    1. Rat-liver mitochondrial DNA (mtDNA) contains at least 8 cleavage sites for the restriction endonuclease Eco RI, 6 for the restriction endonuclease Hind III, 2 for the restriction endonuclease Bam HI and 11 for the restriction endonuclease Hap II. 2. The physical map of the restriction fragments o

  13. Introducción a phpMyAdmin (4/4)

    Suárez Cueto, Armando


    Curso "Introducción al desarrollo web": inserción de filas de relación, modificación de la estructura de una tabla, definición de los valores a mostrar en la inserción de filas en una tabla de relación. Más información en

  14. Fit to Fight: Admin or Ethos? Embedding Fitness in Air Force Culture


    cycle--from the pool of discharge candidates to commander-initiated discharge actions to the number of completed discharges--but such is not available...physical fitness program,34 and Hollywood feels three workouts should be “a mandatory part of the workweek.”35 Here again, commanders do not have to

  15. MySQL Admin Cookbook LITE Configuration, Server Monitoring, Managing Users

    Schneller, Daniel


    This cookbook presents solutions to problems in the form of recipes. Each recipe provides the reader with easy step-by-step descriptions of the actions necessary to accomplish a specific task. Example values and code samples are used throughout the recipes, which makes adaptation for individual needs easy. This book is for ambitious MySQL users as well as professional data center database administrators. Beginners as well as experienced administrators will benefit from this cookbook and get fresh ideas to improve their MySQL environments. Detailed background information will enable them to wid

  16. Intrauterine growth restriction: screening, diagnosis, and management.

    Lausman, Andrea; Kingdom, John; Gagnon, Robert; Basso, Melanie; Bos, Hayley; Crane, Joan; Davies, Gregory; Delisle, Marie-France; Hudon, Lynda; Menticoglou, Savas; Mundle, William; Ouellet, Annie; Pressey, Tracy; Pylypjuk, Christy; Roggensack, Anne; Sanderson, Frank


    Contexte : Le retard de croissance intra-utérin (RCIU) est une complication obstétricale qui, par définition, serait constatée par dépistage chez 10 % des fœtus au sein de la population générale. Le défi consiste à identifier le sous-ensemble des grossesses qui sont affectées par un retard de croissance pathologique, de façon à permettre la mise en œuvre d’une intervention qui atténuerait les taux de morbidité et de mortalité. Objectif : La présente directive clinique a pour objectif de fournir des déclarations sommaires et des recommandations, ainsi que d’établir un cadre pour le dépistage, le diagnostic et la prise en charge des grossesses affectées par un RCIU. Méthodes : Des grossesses affectées sont comparées à des grossesses dans le cadre desquelles le fœtus présente un poids convenant à son âge gestationnel. Les antécédents, l’examen physique et les analyses de laboratoire (y compris les marqueurs biochimiques et les caractéristiques échographiques du RCIU) sont analysées, et une stratégie de prise en charge est suggérée. Résultats : La littérature publiée en anglais a été récupérée par l’intermédiaire de recherches menées dans PubMed ou MEDLINE, CINAHL et The Cochrane Library en janvier 2013, au moyen d’un vocabulaire contrôlé faisant appel à des termes MeSH (« fetal growth restriction » et « small for gestational age ») et à des mots clés (« fetal growth », « restriction », « growth retardation », « IUGR », « low birth weight », « small for gestational age ») appropriés. Les résultats ont été restreints aux analyses systématiques, aux essais comparatifs randomisés / essais cliniques comparatifs et aux études observationnelles. La littérature grise (non publiée) a été identifiée par l’intermédiaire de recherches menées dans les sites Web d’organismes s’intéressant à l’évaluation des technologies dans le domaine de la santé et d

  17. Offspring metabolomic response to maternal protein restriction in a rat model of intrauterine growth restriction (IUGR).

    Alexandre-Gouabau, Marie-Cécile; Courant, Frédérique; Le Gall, Gwénaëlle; Moyon, Thomas; Darmaun, Dominique; Parnet, Patricia; Coupé, Bérengère; Antignac, Jean-Philippe


    Intrauterine growth restriction (IUGR), along with postnatal growth trajectory, is closely linked with metabolic diseases and obesity at adulthood. The present study reports the time-dependent metabolomic response of male offspring of rat dams exposed to maternal adequate protein diet during pregnancy and lactation (CC) or protein deprivation during pregnancy only (IUGR with rapid catch-up growth, RC) or through pregnancy and lactation (IUGR with slow postnatal growth, RR). Plasma LC-HRMS metabolomic fingerprints for 8 male rats per group, combined with multivariate statistical analysis (PLS-DA and HCA), were used to study the impact of IUGR and postnatal growth velocity on the offspring metabolism in early life (until weaning) and once they reached adulthood (8 months). Compared with CC rats, RR pups had clear-cut alterations in plasma metabolome during suckling, but none at adulthood; in contrast, in RC pups, alterations in metabolome were minimal in early life but more pronounced in the long run. In particular, our results pinpoint transient alterations in proline, arginine, and histidine in RR rats, compared to CC rats, and persistent differences in tyrosine and carnitine, compared to RC rats at adulthood. These findings suggest that the long-term deregulation in feeding behavior and fatty acid metabolism in IUGR rats depends on postnatal growth velocity.

  18. HIV restriction by APOBEC3 in humanized mice.

    John F Krisko


    Full Text Available Innate immune restriction factors represent important specialized barriers to zoonotic transmission of viruses. Significant consideration has been given to their possible use for therapeutic benefit. The apolipoprotein B mRNA editing enzyme catalytic polypeptide 3 (APOBEC3 family of cytidine deaminases are potent immune defense molecules capable of efficiently restricting endogenous retroelements as well as a broad range of viruses including Human Immunodeficiency virus (HIV, Hepatitis B virus (HBV, Human Papilloma virus (HPV, and Human T Cell Leukemia virus (HTLV. The best characterized members of this family are APOBEC3G (A3G and APOBEC3F (A3F and their restriction of HIV. HIV has evolved to counteract these powerful restriction factors by encoding an accessory gene designated viral infectivity factor (vif. Here we demonstrate that APOBEC3 efficiently restricts CCR5-tropic HIV in the absence of Vif. However, our results also show that CXCR4-tropic HIV can escape from APOBEC3 restriction and replicate in vivo independent of Vif. Molecular analysis identified thymocytes as cells with reduced A3G and A3F expression. Direct injection of vif-defective HIV into the thymus resulted in viral replication and dissemination detected by plasma viral load analysis; however, vif-defective viruses remained sensitive to APOBEC3 restriction as extensive G to A mutation was observed in proviral DNA recovered from other organs. Remarkably, HIV replication persisted despite the inability of HIV to develop resistance to APOBEC3 in the absence of Vif. Our results provide novel insight into a highly specific subset of cells that potentially circumvent the action of APOBEC3; however our results also demonstrate the massive inactivation of CCR5-tropic HIV in the absence of Vif.

  19. Alteration of placental haemostatic mechanisms in idiopathic intrauterine growth restriction

    Jaime Eduardo Bernal Villegas


    Full Text Available Intrauterine growth restriction is a complication of pregnancy with a high probability of perinatal morbidity and mortality. It appears tobe caused by abnormal development of placental vasculature. Haemostatic processes are important for the development of the placenta,and an imbalance between procoagulant and anticoagulant factors has been associated with risk of intrauterine growth restriction.Objective. To evaluate coagulation abnormalities in placenta of pregnancies complicated with idiopathic intrauterine growth restriction.Materials and methods. Five placentas from pregnancies with idiopathic intrauterine growth restriction were compared to 19 controls.We performed gross and histological examination of the placenta. Analysis was made of both mRNA expression by real-time PCRand protein by ELISA of tissue factor and thrombomodulin in placental tissue. Results. Results based on histological evaluation wereconsistent with an increased prothrombotic state in placentas from pregnancies with idiopathic intrauterine growth restriction, andthrombosis of chorionic vessels was the most important finding. The study showed an increased expression of tissue factor protein(p=0.0411 and an increase in the ratio of tissue factor/thrombomodulin mRNA (p=0.0411 and protein (p=0.0215 in placentas frompregnancies with idiopathic intrauterine growth restriction. There were no statistically significant differences neither between cases andcontrols in the mRNA levels of tissue factor or thrombomodulin nor at the protein level of thrombomodulin. Conclusion. Evidence ofalteration of local haemostatic mechanisms at the level of the placenta, including abnormal expression of tissue factor and tissue factor/thrombomodulin ratio, in pregnancies that occur with idiopathic intrauterine growth restriction is presented.

  20. Restrictions on Software for Personal and Professional Use


    A growing number of computer security incidents detected at CERN are due to additional software installed for personal and professional use. As a consequence, the smooth operation of CERN is put at risk and often many hours are lost solving the problems. To reduce this security risk, installation and/or use of software on CERN's computing and network infrastructure needs to be restricted. Therefore: Do NOT install software for personal use Do NOT install 'free' or other software unless you have the expertise to configure and maintain it securely. Please comply to these rules to keep our computer systems safe. Further explanation of these restrictions is at Restricted software, known to cause security and/or network problems (e.g. KaZaA and other P2P/Peer-to-Peer file sharing applications, Skype P2P telephony software, ICQ, VNC, ...), is listed at:

  1. The Effects of Calorie Restriction in Depression and Potential Mechanisms

    Zhang, Yifan; Liu, Changhong; Zhao, Yinghao; Zhang, Xingyi; Li, Bingjin; Cui, Ranji


    Depression, also called major depressive disorder, is a neuropsychiatric disorder jeopardizing an increasing number of the population worldwide. To date, a large number of studies have devoted great attention to this problematic condition and raised several hypotheses of depression. Based on these theories, many antidepressant drugs were developed for the treatment of depression. Yet, the depressed patients are often refractory to the antidepressant therapies. Recently, increasing experimental evidences demonstrated the effects of calorie restriction in neuroendocrine system and in depression. Both basic and clinical investigations indicated that short-term calorie restriction might induce an antidepressant efficacy in depression, providing a novel avenue for treatment. Molecular basis underlying the antidepressant actions of calorie restriction might involve multiple physiological processes, primarily including orexin signaling activation, increased CREB phosphorylation and neurotrophic effects, release of endorphin and ketone production. However, the effects of chronic calorie restriction were quite controversial, in the cases that it often resulted in the long-term detrimental effects via inhibiting the function of 5-HT system and decreasing leptin levels. Here we review such dual effects of calorie restriction in depression and potential molecular basis behind these effects, especially focusing on antidepressant effects. PMID:26412073

  2. Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response.

    Richardson, Chanté L; Delehanty, Lorrie L; Bullock, Grant C; Rival, Claudia M; Tung, Kenneth S; Kimpel, Donald L; Gardenghi, Sara; Rivella, Stefano; Goldfarb, Adam N


    The unique sensitivity of early red cell progenitors to iron deprivation, known as the erythroid iron restriction response, serves as a basis for human anemias globally. This response impairs erythropoietin-driven erythropoiesis and underlies erythropoietic repression in iron deficiency anemia. Mechanistically, the erythroid iron restriction response results from inactivation of aconitase enzymes and can be suppressed by providing the aconitase product isocitrate. Recent studies have implicated the erythroid iron restriction response in anemia of chronic disease and inflammation (ACDI), offering new therapeutic avenues for a major clinical problem; however, inflammatory signals may also directly repress erythropoiesis in ACDI. Here, we show that suppression of the erythroid iron restriction response by isocitrate administration corrected anemia and erythropoietic defects in rats with ACDI. In vitro studies demonstrated that erythroid repression by inflammatory signaling is potently modulated by the erythroid iron restriction response in a kinase-dependent pathway involving induction of the erythroid-inhibitory transcription factor PU.1. These results reveal the integration of iron and inflammatory inputs in a therapeutically tractable erythropoietic regulatory circuit.

  3. The Optimal Selection for Restricted Linear Models with Average Estimator

    Qichang Xie


    Full Text Available The essential task of risk investment is to select an optimal tracking portfolio among various portfolios. Statistically, this process can be achieved by choosing an optimal restricted linear model. This paper develops a statistical procedure to do this, based on selecting appropriate weights for averaging approximately restricted models. The method of weighted average least squares is adopted to estimate the approximately restricted models under dependent error setting. The optimal weights are selected by minimizing a k-class generalized information criterion (k-GIC, which is an estimate of the average squared error from the model average fit. This model selection procedure is shown to be asymptotically optimal in the sense of obtaining the lowest possible average squared error. Monte Carlo simulations illustrate that the suggested method has comparable efficiency to some alternative model selection techniques.

  4. Avoiding or restricting defectors in public goods games?

    Han, The Anh; Pereira, Luís Moniz; Lenaerts, Tom


    When creating a public good, strategies or mechanisms are required to handle defectors. We first show mathematically and numerically that prior agreements with posterior compensations provide a strategic solution that leads to substantial levels of cooperation in the context of public goods games, results that are corroborated by available experimental data. Notwithstanding this success, one cannot, as with other approaches, fully exclude the presence of defectors, raising the question of how they can be dealt with to avoid the demise of the common good. We show that both avoiding creation of the common good, whenever full agreement is not reached, and limiting the benefit that disagreeing defectors can acquire, using costly restriction mechanisms, are relevant choices. Nonetheless, restriction mechanisms are found the more favourable, especially in larger group interactions. Given decreasing restriction costs, introducing restraining measures to cope with public goods free-riding issues is the ultimate advantageous solution for all participants, rather than avoiding its creation.

  5. Interplay Between Bacteriophages and Restriction-Modification Systems in Enterococci

    Pristas Peter


    Full Text Available The complete genomes of Enterococcus faecalis bacteriophages were analyzed for tetranucleotide words avoidance. Very similar tetranucleotide composition was found in all tested genomes with strong underrepresentation of palindromic GATC and GGCC words. This avoidance could be explained as a protection mechanism against host restriction-modification systems as a clear correlation was found between avoidance of palindromic words and the specificity of E. faecalis restriction and modification systems. No similar avoidance of tetranucleotide words was observed for non-palindromic words. A weak correlation was observed between avoidance of tetranucleotide palindromes in bacteriophage genomes and the possession of phage encoded DNA methyltransferases confirming the interrelation between bacteriophage genomes composition and restriction and modification systems in enterococci

  6. Paternally Inherited IGF2 Mutation and Growth Restriction.

    Begemann, Matthias; Zirn, Birgit; Santen, Gijs; Wirthgen, Elisa; Soellner, Lukas; Büttel, Hans-Martin; Schweizer, Roland; van Workum, Wilbert; Binder, Gerhard; Eggermann, Thomas


    In humans, mutations in IGF1 or IGF1R cause intrauterine and postnatal growth restriction; however, data on mutations in IGF2, encoding insulin-like growth factor (IGF) II, are lacking. We report an IGF2 variant (c.191C→A, p.Ser64Ter) with evidence of pathogenicity in a multigenerational family with four members who have growth restriction. The phenotype affects only family members who have inherited the variant through paternal transmission, a finding that is consistent with the maternal imprinting status of IGF2. The severe growth restriction in affected family members suggests that IGF-II affects postnatal growth in addition to prenatal growth. Furthermore, the dysmorphic features of affected family members are consistent with a role of deficient IGF-II levels in the cause of the Silver-Russell syndrome. (Funded by Bundesministerium für Bildung und Forschung and the European Union.).

  7. Sequence specific inhibition of DNA restriction enzyme cleavage by PNA

    Nielsen, P.E.; Egholm, M.; Berg, R.H.


    Plasmids containing double-stranded 10-mer PNA (peptide nucleic acid chimera) targets proximally flanked by two restriction enzyme sites were challenged with the complementary PNA or PNAs having one or two mismatches, and the effect on the restriction enzyme cleavage of the flanking sites...... was assayed. The following PNAs were used: T10-LysNH2, T5CT4-LysNH2 and T2CT2CT4-LysNH2 and the corresponding targets cloned into pUC 19 were flanked by BamH1, Sal1 or Pstl sites, respectively. In all cases it was found that complete inhibition of restriction enzyme cleavage was obtained...

  8. Restricted use of antibiotics in organic pig farming

    Aabo, Søren; Jensen, Annette Nygaard


    Can the restricted use of antibiotics in organic pig farming be documented to provide a safer, high quality meat product with less antibiotic resistant bacteria? The project SafeOrganic aims to document that the restricted use of antimicrobials in organic pig production leads to lower levels...... of antibiotic resistant bacteria compared with the level in conventional pigs. However, the project will also address the risk of losing this quality parameter, due to a widespread practice of slaughtering organic pigs together with conventional pigs, implying a risk of cross-contamination....

  9. Dietary tyramine restriction for hospitalized patients on linezolid: an update.

    Rumore, Martha M; Roth, Marc; Orfanos, Areti


    Linezolid is a weak, reversible monoamine oxidase inhibitor. The current practice at most hospitals is to place patients receiving linezolid on a tyramine-restricted diet. This process typically involves both the hospital's pharmacy department and the food and nutrition department. A literature search assessing the interaction between linezolid and tyramine was conducted, and the amount of tyramine in a typical unrestricted diet for a hospitalized patient was reviewed. Although patients receiving linezolid should avoid consuming large amounts of foods containing high concentrations of tyramine, such foods in large amounts are not components of meals for inpatients. Therefore, dietary tyramine restriction in hospitalized patients is not generally required.

  10. Study on modulation techniques free of orthogonality restriction


    The Nyquist rate is a limit of transmission for traditional modulation methods from orthogonality restriction. Nonorthogonal modulation techniques (NMT) is proposed, which removes the orthogonality restriction, and as a result, higher bandwidth efficiency than the traditional methods can be achieved. First, the symbol error rate of NMT is introduced by using estimation theory. Then the relation between bandwidth efficiency and signal to noise ratio is discussed. Finally, a design instance of NMT is present and numerical experiment is made. This study explores for new modulation methods and points out a widened direction for modulation theory and applications.

  11. Restricting factors of the development of SEA in China

    Wang Xianghua; Zhu Xiaodong; LiYangfan; Chen Shanshan


    "Environmental Impact Assessment Law of P. R. China" was promulgated on Oct. 28th, 2002 and has been put into effect on Sep 1st, 2003. This paper puts forward some important factors which restrict the development of Strategic Environmental Assessment according to the preliminary practices of SEA in China. These restricting factors are: (1) potential resistance from some departments; (2) poor cooperation between different departments; (3) limited availability of information resources; (4) lack of well-developed SEA methods; (5) difficulties in public participation. The primary thought to solve these problems were proposed at policy and technique level.

  12. Restriction Theorem for Principal bundles in Arbitrary Characteristic

    Gurjar, Sudarshan


    The aim of this paper is to prove two basic restriction theorem for principal bundles on smooth projective varieties in arbitrary characteristic generalizing the analogues theorems of Mehta-Ramanathan for vector bundles. More precisely, let G be a reductive algebraic group over an algebraically...... closed field k and let X be a smooth, projective variety over k together with a very ample line bundle O(1). The main result of the paper is that if E is a semistable (resp. stable) principal G-bundle on X w.r.t O(1), then the restriction of E to a general, high multi-degree, complete-intersection curve...

  13. Traffic restrictions due to wind on the Fehmarn Belt bridge

    Dellwik, E.; Mann, Jakob; Rosenhagen, G.


    This report documents the calculations carried out in order to estimate the wind climate at the site where the Fehmarn Belt bridge is planned. Further, an estimate of how often and for how long traffic restrictions will be enforced according to statedcriteria (sec. 3.2) is given. This estimate...... is given both as a total percentage of time and as a mean distribution of restrictions over the year. We perform the same analysis for the Øresund and the Great Belt bridge and compare the result with the actualfractions. Only during the last year of operation of the Øresund bridge the criteria...

  14. The restricted isometry property meets nonlinear approximation with redundant frames

    Gribonval, Rémi; Nielsen, Morten

    It is now well known that sparse or compressible vectors can be stably recovered from their low-dimensional projection, provided the projection matrix satisfies a Restricted Isometry Property (RIP). We establish new implications of the RIP with respect to nonlinear approximation in a Hilbert spac...

  15. 30 CFR 57.4461 - Gasoline use restrictions underground.


    ... 30 Mineral Resources 1 2010-07-01 2010-07-01 false Gasoline use restrictions underground. 57.4461 Section 57.4461 Mineral Resources MINE SAFETY AND HEALTH ADMINISTRATION, DEPARTMENT OF LABOR METAL AND... with wood or other combustible materials....

  16. 28 CFR 540.15 - Restricted general correspondence.


    ... restricted general correspondence; (ii) Shall give the inmate the opportunity to respond to the... approved correspondence list, subject to investigation, evaluation, and approval by the Warden; with prior... investigation; and (3) Correspond with former business associates, unless it appears to the Warden that...

  17. Fetal Growth Restriction at the Limits of Viability

    Visser, G. H. A.; Bilardo, Caterina M.; Lees, Christopher


    The outcome of early small-for-gestational age and/or intrauterine growth-restricted fetuses is reviewed. In these fetuses the outcome appears to be considerably poorer than that of appropriately grown fetuses and this seems mainly to be caused by intrauterine malnutrition rather than by hypoxemia.

  18. Defense Acquisition: Rationale for Imposing Domestic Source Restrictions.


    for polyacrylonitrile-based carbon fiber, periscope tube forgings, bull gear ring forgings, and ship propulsion shaft forgings. In its review of...manufacturing processes, which could compromise the effectiveness of selected Navy systems. The restriction on ship propulsion shaft forgings was...sensitive data Ship propulsion shaft forgings 1984 Unsettled conditions among suppliers In its reviews of industrial base capabilities, DOD sometimes

  19. 5 CFR 1216.207 - Restrictions that apply to testimony.


    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Restrictions that apply to testimony. 1216.207 Section 1216.207 Administrative Personnel MERIT SYSTEMS PROTECTION BOARD ORGANIZATION AND... of the United States (see also 5 CFR 2635.805). (d) The scheduling of an employee's...

  20. 5 CFR 2417.207 - Restrictions that apply to testimony.


    ... 5 Administrative Personnel 3 2010-01-01 2010-01-01 false Restrictions that apply to testimony. 2417.207 Section 2417.207 Administrative Personnel FEDERAL LABOR RELATIONS AUTHORITY, GENERAL COUNSEL... behalf of the United States (see also 5 CFR 2635.805). (d) The scheduling of an employee's...

  1. Consensus definition of fetal growth restriction : a Delphi procedure

    Gordijn, S. J.; Beune, I. M.; Thilaganathan, B.; Papageorghiou, A.; Baschat, A. A.; Baker, P. N.; Silver, R. M.; Wynia, K.; Ganzevoort, W.


    Objective To determine, by expert consensus, a definition for early and late fetal growth restriction (FGR) through a Delphi procedure. Method A Delphi survey was conducted among an international panel of experts on FGR. Panel members were provided with 18 literature-based parameters for defining FG

  2. Reimbursement restriction moderately decreases Benzodiazepine use in general practice.

    Hoebert, J.M.; Souverein, P.C.; Mantel-Teeuwisse, A.K.; Leufkens, H.G.M.; Dijk, L. van


    Problem Statement: On January 1st 2009, benzodiazepines were excluded from the Dutch positive reimbursement list when used as anxiolytic, hypnotic or sedative, to limit misuse and for cost savings. Thus far, the (un)intended effects of this reimbursement restriction are unknown. Objective(s): To ass

  3. Reimbursement restriction moderately decreases benzodiazepine use in general practice.

    Hoebert, J.M.; Souverein, P.C.; Mantel, A.K.; Leufkens, B.G.M.; Dijk, L. van


    Background: On January 1st 2009, benzodiazepines were excluded from the Dutch positive reimbursement list when used as anxiolytic, hypnotic or sedative, to limit misuse and for cost savings. Thus far, the (un)intended effects of this reimbursement restriction are unknown. Objectives: To assess the i

  4. 7 CFR 930.163 - Deferment of restricted obligation.


    ... SERVICE (Marketing Agreements and Orders; Fruits, Vegetables, Nuts), DEPARTMENT OF AGRICULTURE TART CHERRIES GROWN IN THE STATES OF MICHIGAN, NEW YORK, PENNSYLVANIA, OREGON, UTAH, WASHINGTON, AND WISCONSIN... bond on restricted percentage cherries to be posted to temporarily defer the date that...

  5. Evaluation of Feeding Torerance in Intrauterine Growth Restricted Preterm Infants

    Bozzetti, V.


    Intra Uterine Growth Restriction (IUGR) is an important and common problem in obstetrics. The purpose of the present thesis was to investigate: 1. Feeding issues in IUGR preterm infants; 2. Clinical and strumental parameters as predictors of feeding tolerance in IUGR preterm infants; 3. Splanchnic a

  6. Stability Analysis of Nonlinear Systems with Slope Restricted Nonlinearities

    Xian Liu


    Full Text Available The problem of absolute stability of Lur’e systems with sector and slope restricted nonlinearities is revisited. Novel time-domain and frequency-domain criteria are established by using the Lyapunov method and the well-known Kalman-Yakubovich-Popov (KYP lemma. The criteria strengthen some existing results. Simulations are given to illustrate the efficiency of the results.

  7. 32 CFR 1903.16 - Restriction on animals.


    ... assistance of persons with disabilities, or animals under the charge and control of the Central Intelligence... 32 National Defense 6 2010-07-01 2010-07-01 false Restriction on animals. 1903.16 Section 1903.16 National Defense Other Regulations Relating to National Defense CENTRAL INTELLIGENCE AGENCY CONDUCT...

  8. Proposal of Realization Restricted Quantum Game with Linear Optic Method

    ZHAO Hai-Jun; FANG Xi-Ming


    We present a quantum game with the restricted strategic space and its realization with linear optical system, which can be played by two players who are separated remotely. This game can also be realized on any other quantum computers. We find that the constraint brings some interesting properties that are useful for making game models.

  9. Still Playing It Safe: Restricted Realism in Teen Novels

    Abramson, Jane


    The restrictions on teen fiction result in books that succeed only in mirroring a slick surface realism that too often acts as a cover-up. It disguises the fact that, at their core, most realistic novels are unrealistic and, far worse, dishonest. (Author)

  10. Differentially Private Data Analysis of Social Networks via Restricted Sensitivity

    Blocki, Jeremiah; Datta, Anupam; Sheffet, Or


    We introduce the notion of restricted sensitivity as an alternative to global and smooth sensitivity to improve accuracy in differentially private data analysis. The definition of restricted sensitivity is similar to that of global sensitivity except that instead of quantifying over all possible datasets, we take advantage of any beliefs about the dataset that a querier may have, to quantify over a restricted class of datasets. Specifically, given a query f and a hypothesis H about the structure of a dataset D, we show generically how to transform f into a new query f_H whose global sensitivity (over all datasets including those that do not satisfy H) matches the restricted sensitivity of the query f. Moreover, if the belief of the querier is correct (i.e., D is in H) then f_H(D) = f(D). If the belief is incorrect, then f_H(D) may be inaccurate. We demonstrate the usefulness of this notion by considering the task of answering queries regarding social-networks, which we model as a combination of a graph and a ...

  11. Distribution Learning in Evolutionary Strategies and Restricted Boltzmann Machines

    Krause, Oswin

    The thesis is concerned with learning distributions in the two settings of Evolutionary Strategies (ESs) and Restricted Boltzmann Machines (RBMs). In both cases, the distributions are learned from samples, albeit with different goals. Evolutionary Strategies are concerned with finding an optimum ...

  12. Data Input and Content Exploration in Scenarios with Restrictions

    Pedrosa, D.C.


    As technology evolves, new devices and interaction techniques are developed. These transformations create several challenges in terms of usability and user experience. Our research faces some challenges for data input or content exploration in scenarios with restrictions. It is not our intention to

  13. Airflow-Restricting Mask Reduces Acute Performance in Resistance Exercise

    Yuri L. Motoyama


    Full Text Available Background: The aim of this study was to compare the number of repetitions to volitional failure, the blood lactate concentration, and the perceived exertion to resistance training with and without an airflow-restricting mask. Methods: Eight participants participated in a randomized, counterbalanced, crossover study. Participants were assigned to an airflow-restricting mask group (MASK or a control group (CONT and completed five sets of chest presses and parallel squats until failure at 75% one-repetition-maximum test (1RM with 60 s of rest between sets. Ratings of perceived exertion (RPEs, blood lactate concentrations (Lac−, and total repetitions were taken after the training session. Results: MASK total repetitions were lower than those of the CONT, and (Lac− and MASK RPEs were higher than those of the CONT in both exercises. Conclusions: We conclude that an airflow-restricting mask in combination with resistance training increase perceptions of exertion and decrease muscular performance and lactate concentrations when compared to resistance training without this accessory. This evidence shows that the airflow-restricting mask may change the central nervous system and stop the exercise beforehand to prevent some biological damage.

  14. 7 CFR 322.13 - General requirements; restricted organisms.


    ... 7 Agriculture 5 2010-01-01 2010-01-01 false General requirements; restricted organisms. 322.13 Section 322.13 Agriculture Regulations of the Department of Agriculture (Continued) ANIMAL AND PLANT HEALTH INSPECTION SERVICE, DEPARTMENT OF AGRICULTURE BEES, BEEKEEPING BYPRODUCTS, AND...

  15. Guiding IEP Teams on Meeting the Least Restrictive Environment Mandate

    Marx, Teri A.; Hart, Jennifer L.; Nelson, Leslie; Love, Jessica; Baxter, Christine M.; Gartin, Barbara; Schaefer Whitby, Peggy J.


    Two diametrically opposed beliefs are held concerning the meaning of the least restrictive environment (LRE) when determining the class placements of students with disabilities. One group adheres to the placement philosophy that the LRE is always the general education setting. The other group believes that the LRE is where the students' needs may…

  16. Gender differences in delay-discounting under mild food restriction

    Koot, S.; van den Bos, R.; Adriani, W.; Laviola, G.


    Abstract: Impulsivity, a core symptomof attention-deficit hyperactivity disorder (ADHD), is tested in animal models by delay-discounting tasks. So far, mainly male subjects have been used in this paradigm at severe levels of food restriction. Here we studied the impulsive behaviour of CD-1 adult mal

  17. Associations between Schools' Tobacco Restrictions and Adolescents' Use of Tobacco

    Oslash-Verland, Simon; Aaro, Leif Edvard; Lindbak, Rita Lill


    Schools are an important arena for smoking prevention. In many countries, smoking rates have been reduced among adolescents, but the use of smokeless tobacco is on the rise in some of these countries. We aimed to study the associations between schools' restrictions on smoking and snus and on the use of these tobacco products among students in…

  18. 50 CFR 300.223 - Purse seine fishing restrictions.


    ... seine fishing restrictions. All dates used in this section are in Universal Coordinated Time, also known... within the Convention Area takes place entirely within areas under U.S. jurisdiction or entirely within areas under jurisdiction of a single nation other than the United States. (ii) No fishing takes...

  19. Drunkorexia: Calorie Restriction Prior to Alcohol Consumption among College Freshman

    Burke, Sloane C.; Cremeens, Jennifer; Vail-Smith, Karen; Woolsey, Conrad


    Using a sample of 692 freshmen at a southeastern university, this study examined caloric restriction among students prior to planned alcohol consumption. Participants were surveyed for self-reported alcohol consumption, binge drinking, and caloric intake habits prior to drinking episodes. Results indicated that 99 of 695 (14%) of first year…

  20. 50 CFR 635.40 - Restrictions to enhance conservation.


    ... by the declaration(s) required by 19 CFR 10.79. The “Declaration of Master and Two Members of Crew on Entry of Products of American Fisheries” required by 19 CFR 10.79 must contain a further statement as... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Restrictions to enhance conservation....

  1. Calvin's Restrictions on Interest : Guidelines for the Credit Crisis

    Graafland, J.J.


    Calvin’s view on the legitimacy of interest has had a great impact on the economic development of Western society. Although Calvin took a fundamentally positive attitude to interest, he also proposed several restrictions on the charging of interest. In this article, we investigate the relevance of t

  2. Designing Intervention Studies: Selected Populations, Range Restrictions, and Statistical Power

    Miciak, Jeremy; Taylor, W. Pat; Stuebing, Karla K.; Fletcher, Jack M.; Vaughn, Sharon


    An appropriate estimate of statistical power is critical for the design of intervention studies. Although the inclusion of a pretest covariate in the test of the primary outcome can increase statistical power, samples selected on the basis of pretest performance may demonstrate range restriction on the selection measure and other correlated…

  3. 40 CFR 52.24 - Statutory restriction on new sources.


    ... longer in effect in that area, then the requirements of § 51.165 of this chapter shall apply to the... restriction on new sources. (a) Any area designated nonattainment pursuant to section 107(d) of the Act to... containing such an area: (1) Failed to submit an implementation plan meeting the requirements of...

  4. The restricted isometry property meets nonlinear approximation with redundant frames

    Gribonval, Rémi; Nielsen, Morten


    It is now well known that sparse or compressible vectors can be stably recovered from their low-dimensional projection, provided the projection matrix satisfies a Restricted Isometry Property (RIP). We establish new implications of the RIP with respect to nonlinear approximation in a Hilbert space...

  5. Moment Restriction-based Econometric Methods: An Overview

    N. Kunitomo (Naoto); M.J. McAleer (Michael); Y. Nishiyama (Yoshihiko)


    textabstractMoment restriction-based econometric modelling is a broad class which includes the parametric, semiparametric and nonparametric approaches. Moments and conditional moments themselves are nonparametric quantities. If a model is specified in part up to some finite dimensional parameters, t

  6. Testing exclusion restrictions and additive separability in sample selection models

    Huber, Martin; Mellace, Giovanni


    Standard sample selection models with non-randomly censored outcomes assume (i) an exclusion restriction (i.e., a variable affecting selection, but not the outcome) and (ii) additive separability of the errors in the selection process. This paper proposes tests for the joint satisfaction of these......Standard sample selection models with non-randomly censored outcomes assume (i) an exclusion restriction (i.e., a variable affecting selection, but not the outcome) and (ii) additive separability of the errors in the selection process. This paper proposes tests for the joint satisfaction...... of these assumptions by applying the approach of Huber and Mellace (Testing instrument validity for LATE identification based on inequality moment constraints, 2011) (for testing instrument validity under treatment endogeneity) to the sample selection framework. We show that the exclusion restriction and additive...... separability imply two testable inequality constraints that come from both point identifying and bounding the outcome distribution of the subpopulation that is always selected/observed. We apply the tests to two variables for which the exclusion restriction is frequently invoked in female wage regressions: non...

  7. 50 CFR 648.140 - Catch quotas and other restrictions.


    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Catch quotas and other restrictions. 648.140 Section 648.140 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND... exploitation rate of 23 percent (based on Fmax) in 2003 and subsequent years: Commercial, recreational,...

  8. 50 CFR 648.120 - Catch quotas and other restrictions.


    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Catch quotas and other restrictions. 648.120 Section 648.120 Wildlife and Fisheries FISHERY CONSERVATION AND MANAGEMENT, NATIONAL OCEANIC AND... Committee of the MAFMC and the Commission to ensure that the exploitation rate specified in paragraph (a)...

  9. Phenylketonuria : tyrosine supplementation in phenylalanine-restricted diets

    van Spronsen, FJ; van Rijn, M; Bekhof, J; Koch, R; Smit, PGA


    Treatment of phenylketonuria (PKU) consists of restriction of natural protein and provision of a protein substitute that lacks phenylalanine but is enriched in tyrosine. Large and unexplained differences exist, however, in the tyrosine enrichment of the protein substitutes. Furthermore, some investi

  10. 28 CFR 549.13 - Programming, duty, and housing restrictions.


    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Programming, duty, and housing... INSTITUTIONAL MANAGEMENT MEDICAL SERVICES Infectious Disease Management § 549.13 Programming, duty, and housing restrictions. (a) The CD will assess any inmate with an infectious disease for appropriateness for...

  11. Concept to comfort-condition subjects wearing restrictive clothing

    Tucker, E. M.


    Heat exchanger maintains a desirable thermal balance in a subject wearing restrictive clothing. A grid of high thermal conductance fibers, in contact with the skin, transfers heat to or from the skin surface by means of a system of ducts, carrying the transfer fluid which is maintained at a controlled temperature.

  12. 78 FR 51696 - Restrictions on Legal Assistance to Aliens


    ... 45 CFR Part 1626 Restrictions on Legal Assistance to Aliens AGENCY: Legal Services Corporation... Legal Services Corporation (LSC or Corporation) regulation on legal assistance to aliens. The revisions are intended to implement three statutory changes on aliens eligible for legal assistance from...

  13. Kamm on Inviolability and Agent-Relative Restrictions

    Lippert-Rasmussen, Kasper


    Abstract  Agent-relative restrictions prohibit minimizing violations: that is, they require us not to minimize the total number of their violations by violating them ourselves. Frances Kamm has explained this prohibition in terms of the moral worth of persons, which, in turn, she explains in terms...

  14. 9 CFR 93.910 - General restrictions; exceptions.


    ... VHS virus has been isolated in cell culture or other assay determined by the competent authority to be... 9 Animals and Animal Products 1 2010-01-01 2010-01-01 false General restrictions; exceptions. 93.910 Section 93.910 Animals and Animal Products ANIMAL AND PLANT HEALTH INSPECTION SERVICE,...

  15. 36 CFR 9.18 - Surface use and patent restrictions.


    ... 36 Parks, Forests, and Public Property 1 2010-07-01 2010-07-01 false Surface use and patent... INTERIOR MINERALS MANAGEMENT Mining and Mining Claims § 9.18 Surface use and patent restrictions. (a) The... to any claimant who wishes to take his claim to patent in Olympic National Park, Glacier Bay...

  16. A Few Endpoint Geodesic Restriction Estimates for Eigenfunctions

    Chen, Xuehua; Sogge, Christopher D.


    We prove a couple of new endpoint geodesic restriction estimates for eigenfunctions. In the case of general 3-dimensional compact manifolds, after a TT* argument, simply by using the L 2-boundedness of the Hilbert transform on , we are able to improve the corresponding L 2-restriction bounds of Burq, Gérard and Tzvetkov (Duke Math J 138:445-486, 2007) and Hu (Forum Math 6:1021-1052, 2009). Also, in the case of 2-dimensional compact manifolds with nonpositive curvature, we obtain improved L 4-estimates for restrictions to geodesics, which, by Hölder's inequality and interpolation, implies improved L p -bounds for all exponents p ≥ 2. We do this by using oscillatory integral theorems of Hörmander (Ark Mat 11:1-11, 1973), Greenleaf and Seeger (J Reine Angew Math 455:35-56, 1994) and Phong and Stein (Int Math Res Notices 4:49-60, 1991), along with a simple geometric lemma (Lemma 3.2) about properties of the mixed-Hessian of the Riemannian distance function restricted to pairs of geodesics in Riemannian surfaces. We are also able to get further improvements beyond our new results in three dimensions under the assumption of constant nonpositive curvature by exploiting the fact that, in this case, there are many totally geodesic submanifolds.

  17. Sleep Restriction Worsens Mood and Emotion Regulation in Adolescents

    Baum, Katherine T.; Desai, Anjali; Field, Julie; Miller, Lauren E.; Rausch, Joseph; Beebe, Dean W.


    Background: The relationship between inadequate sleep and mood has been well-established in adults and is supported primarily by correlational data in younger populations. Given that adolescents often experience shortened sleep on school nights, we sought to better understand the effect of experimentally induced chronic sleep restriction on…

  18. A whole genome screen for HIV restriction factors

    Liu Li


    Full Text Available Abstract Background Upon cellular entry retroviruses must avoid innate restriction factors produced by the host cell. For human immunodeficiency virus (HIV human restriction factors, APOBEC3 (apolipoprotein-B-mRNA-editing-enzyme, p21 and tetherin are well characterised. Results To identify intrinsic resistance factors to HIV-1 replication we screened 19,121 human genes and identified 114 factors with significant inhibition of infection. Those with a known function are involved in a broad spectrum of cellular processes including receptor signalling, vesicle trafficking, transcription, apoptosis, cross-nuclear membrane transport, meiosis, DNA damage repair, ubiquitination and RNA processing. We focused on the PAF1 complex which has been previously implicated in gene transcription, cell cycle control and mRNA surveillance. Knockdown of all members of the PAF1 family of proteins enhanced HIV-1 reverse transcription and integration of provirus. Over-expression of PAF1 in host cells renders them refractory to HIV-1. Simian Immunodeficiency Viruses and HIV-2 are also restricted in PAF1 expressing cells. PAF1 is expressed in primary monocytes, macrophages and T-lymphocytes and we demonstrate strong activity in MonoMac1, a monocyte cell line. Conclusions We propose that the PAF1c establishes an anti-viral state to prevent infection by incoming retroviruses. This previously unrecognised mechanism of restriction could have implications for invasion of cells by any pathogen.

  19. 75 FR 20796 - Market-Based Rate Affiliate Restrictions


    ... requires that, as a condition of receiving and retaining market-based rate authority, sellers comply with...-based rate sellers to share employees that may not currently be shared under the affiliate restrictions... requirements for market-based rate sellers were approved under FERC-919 ``Market-Based Rates for...

  20. 50 CFR 648.88 - Multispecies open access permit restrictions.


    ... 50 Wildlife and Fisheries 8 2010-10-01 2010-10-01 false Multispecies open access permit... Management Measures for the NE Multispecies and Monkfish Fisheries § 648.88 Multispecies open access permit restrictions. (a) Handgear permit. A vessel issued a valid open access NE multispecies Handgear permit...

  1. Diagnostic features of feline restrictive orbital myofibroblastic sarcoma.

    Bell, C M; Schwarz, T; Dubielzig, R R


    A progressive debilitating disease of the orbit and adjacent connective tissues of cats has historically been called feline orbital pseudotumor. The authors reviewed clinical, histopathologic, and diagnostic imaging features of this disease in 12 cases from the Comparative Ocular Pathology Laboratory of Wisconsin. The cats' ages ranged from 7 to 16 years (mean, 10.8 years). All cats had a history of severely restricted mobility of the globe and eyelids with secondary corneal disease. Eleven cats (92%) had concurrent involvement of the contralateral eye and/or the oral cavity. Diffuse scleral or episcleral thickening was seen with computed tomography in all clinically affected eyes. Histologically, an insidious infiltration of neoplastic spindle cells in the orbit, eyelids, and periorbital skin and soft tissues, with collagen deposition and a few perivascular lymphocytes, led to entrapment and restricted mobility of the eyelids and orbital tissues. The tumor failed to form a discrete mass, and it spread along fascial planes to the contralateral orbit and eyelids and/or the lips and oral cavity. In all tested cases (n = 10), neoplastic cells were immunohistochemically positive for vimentin, S100 protein, and smooth muscle actin. The authors adopted the term feline restrictive orbital myofibroblastic sarcoma to reflect the restricted mobility of the eyelids and globe and the imaging and histologic features of an invasive yet low-grade myofibroblastic sarcoma.

  2. 10 CFR 1016.21 - Protection of Restricted Data in storage.


    ... 10 Energy 4 2010-01-01 2010-01-01 false Protection of Restricted Data in storage. 1016.21 Section 1016.21 Energy DEPARTMENT OF ENERGY (GENERAL PROVISIONS) SAFEGUARDING OF RESTRICTED DATA Physical Security § 1016.21 Protection of Restricted Data in storage. (a) Persons who possess Restricted...

  3. 10 CFR 2.903 - Protection of restricted data and national security information.


    ... 10 Energy 1 2010-01-01 2010-01-01 false Protection of restricted data and national security... Restricted Data and/or National Security Information § 2.903 Protection of restricted data and national security information. Nothing in this subpart shall relieve any person from safeguarding Restricted Data...

  4. 78 FR 40958 - Amendment of Restricted Areas R-2504A & R-2504B; Camp Roberts, CA, and Restricted Area R-2530...


    ...-2504B; Camp Roberts, CA, and Restricted Area R-2530; Sierra Army Depot, CA AGENCY: Federal Aviation...- 2504A and R-2504B, Camp Roberts, CA, and restricted area R-2530, Sierra Army Depot, CA, by removing the... time is in effect. The intended time of designation for restricted areas R-2504A and R- 2504B is...

  5. Unaccompanied adolescents seeking asylum - Poorer mental health under a restrictive reception : poorer mental health under a restrictive reception

    Reijneveld, S.A.; de Boer, J.B.; Bean, T.; Korfker, D.G.


    We assessed the effects of a stringent reception policy on the mental health of unaccompanied adolescent asylum seekers by comparing the mental health of adolescents in a restricted campus reception setting and in a setting offering more autonomy (numbers [response rates]: 69 [93%] and 53 [69%], res

  6. Temi firthiani di linguistica applicata: "Restricted Languages" e "Collocation" (Firthian Themes in Applied Linguistics: "Restricted Languages" and "Collocation")

    Leonardi, Magda


    Discusses the importance of two Firthian themes for language teaching. The first theme, "Restricted Languages," concerns the "microlanguages" of every language (e.g., literary language, scientific, etc.). The second theme, "Collocation," shows that equivalent words in two languages rarely have the same position in both languages. (Text is in…

  7. Temi firthiani di linguistica applicata: "Restricted Languages" e "Collocation" (Firthian Themes in Applied Linguistics: "Restricted Languages" and "Collocation")

    Leonardi, Magda


    Discusses the importance of two Firthian themes for language teaching. The first theme, "Restricted Languages," concerns the "microlanguages" of every language (e.g., literary language, scientific, etc.). The second theme, "Collocation," shows that equivalent words in two languages rarely have the same position in…

  8. FAQs about the GOLD 2011 assessment proposal of COPD

    Agusti, Alvar; Hurd, Suzanne; Jones, Paul;


    Since the publication of the new Global Initiative for Chronic Obstructive Lung Disease (GOLD) proposal for the assessment of chronic obstructive lung disease (COPD), four studies have used existing cohorts to explore the characteristics, temporal variability and/or relationship with outcomes...... but surprisingly similar (and intermediate) in B and C; and 5) the incidence of exacerbations during follow-up increases progressively from A to D but that of hospitalisations behave similarly to mortality. These results identify several strengths and shortcomings of the new GOLD assessment proposal, particularly...

  9. American Trypanosomiasis (Also Known as Chagas Disease) Detailed FAQs

    ... the Caribbean (for example, in Puerto Rico or Cuba). Rare vectorborne cases of Chagas disease have been ... constructed facilities (for example, air-conditioned or screened hotel rooms), are at low risk for exposure to ...

  10. MedlinePlus Connect: Frequently Asked Questions (FAQs)

    ... provides an on-demand, formatted MedlinePlus Connect Web page. The Web service returns XML, JSON, or JSONP, which allows ... the two, check out the Web application demonstration page and the Web service demonstration page . Both the MedlinePlus Connect Web ...

  11. MedlinePlus FAQ: Information on Doctors or Hospitals

    ... this page, please enable JavaScript. Answer: Many health topic pages in MedlinePlus contain a section which lists directories of doctors and services relevant to the topic. The Directories page lists many sources of information about physicians, other ...

  12. Coaching Considerations: FAQs Useful in the Development of Literacy Coaching

    Fisher, Douglas


    The National Advisory Board for the Literacy Coaching Clearinghouse have identified a number of considerations that it believed needed further discussion as schools, districts, and states embrace literacy coaching. It negotiated and discussed a number of issues surrounding coaching and agreed on 10 key ideas that should be part of the discussions…

  13. Tracks FAQs: What Chemicals Are In My Drinking Water?


    In this podcast, CDC Tracking experts discuss how you can use the Tracking Network to determine what chemicals are in your drinking water. Do you have a question for our Tracking experts? Please e-mail questions to  Created: 8/10/2011 by National Center for Environmental Health, Division of Environmental Hazards and Health Effects, Environmental Health Tracking Branch.   Date Released: 8/10/2011.

  14. American Trypanosomiasis (Also Known as Chagas Disease) Triatomine Bug FAQs

    ... the blood of mammals (including humans), birds, and reptiles. Triatomine bugs live in a wide range of environmental settings, generally within close proximity to a blood host. In areas of Latin America where human Chagas disease is an important public ...

  15. Intracellular diffusion restrictions in isolated cardiomyocytes from rainbow trout

    Birkedal Rikke


    Full Text Available Abstract Background Restriction of intracellular diffusion of adenine nucleotides has been studied intensively on adult rat cardiomyocytes. However, their cause and role in vivo is still uncertain. Intracellular membrane structures have been suggested to play a role. We therefore chose to study cardiomyocytes from rainbow trout (Oncorhynchus mykiss, which are thinner and have fewer intracellular membrane structures than adult rat cardiomyocytes. Previous studies suggest that trout permeabilized cardiac fibers also have diffusion restrictions. However, results from fibers may be affected by incomplete separation of the cells. This is avoided when studying permeabilized, isolated cardiomyocytes. The aim of this study was to verify the existence of diffusion restrictions in trout cardiomyocytes by comparing ADP-kinetics of mitochondrial respiration in permeabilized fibers, permeabilized cardiomyocytes and isolated mitochondria from rainbow trout heart. Experiments were performed at 10, 15 and 20°C in the absence and presence of creatine. Results Trout cardiomyocytes hypercontracted in the solutions used for mammalian cardiomyocytes. We developed a new solution in which they retained their shape and showed stable steady state respiration rates throughout an experiment. The apparent ADP-affinity of permeabilized cardiomyocytes was different from that of fibers. It was higher, independent of temperature and not increased by creatine. However, it was still about ten times lower than in isolated mitochondria. Conclusions The differences between fibers and cardiomyocytes suggest that results from trout heart fibers were affected by incomplete separation of the cells. However, the lower ADP-affinity of cardiomyocytes compared to isolated mitochondria indicate that intracellular diffusion restrictions are still present in trout cardiomyocytes despite their lower density of intracellular membrane structures. The lack of a creatine effect indicates that

  16. Restrictive versus liberal transfusion strategy for red blood cell transfusion

    Holst, Lars B; Petersen, Marie W; Haase, Nicolai;


    OBJECTIVE: To compare the benefit and harm of restrictive versus liberal transfusion strategies to guide red blood cell transfusions. DESIGN: Systematic review with meta-analyses and trial sequential analyses of randomised clinical trials. DATA SOURCES: Cochrane central register of controlled...... trials, SilverPlatter Medline (1950 to date), SilverPlatter Embase (1980 to date), and Science Citation Index Expanded (1900 to present). Reference lists of identified trials and other systematic reviews were assessed, and authors and experts in transfusion were contacted to identify additional trials....... TRIAL SELECTION: Published and unpublished randomised clinical trials that evaluated a restrictive compared with a liberal transfusion strategy in adults or children, irrespective of language, blinding procedure, publication status, or sample size. DATA EXTRACTION: Two authors independently screened...

  17. The effect of quantum noise on the restricted quantum game

    Cao Shuai; Fang Mao-Fa


    It has recently been established that quantum strategies have great advantage over classical ones in quantum games. However, quantum states are easily affected by the quantum noise resulting in decoherence. In this paper, we investigate the effect of quantum noise on the restricted quantum game in which one player is restricted in classical strategic space, another in quantum strategic space and only the quantum player is affected by the quantum noise. Our results show that in the maximally entangled state, no Nash equilibria exist in the range of 0< p≤0.422 (p is the quantum noise parameter), while two special Nash equilibria appear in the range of 0.422 < p< 1. The advantage that the quantum player diminished only in the limit of maximum quantum noise. Increasing the amount of quantum noise leads to the increase of the classical player's payoff and the reduction of the quantum player's payoff, but is helpful in forming two Nash equilibria.

  18. Restrictive extraocular myopathy: A presenting feature of acromegaly

    Steven Heireman


    Full Text Available A 45-year-old man presented with binocular diplopia in primary gaze for 1 year. Orthoptic evaluation showed 10-prism diopter right eye hypotropia and 6-prism diopter right eye esotropia. The elevation and abduction of the right eye were mechanically restricted. This was associated with systemic features suggestive of acromegaly. Magnetic resonance imaging (MRI of the brain demonstrated a pituitary macroadenoma. An elevated serum insulin-like growth factor I level and the failure of growth hormone suppression after an oral glucose load biochemically confirmed the diagnosis of acromegaly. Computed tomography (CT of the orbit demonstrated bilateral symmetrical enlargement of the medial rectus and inferior rectus muscle bellies. All tests regarding Graves-Basedow disease were negative. Although rare, diplopia due to a restrictive extraocular myopathy could be the presenting symptom of acromegaly.

  19. Insights into restrictive cardiomyopathy from clinical and animal studies

    Pierre-Yves Jean-Charles; Yue-Jin Li; Chang-Long Nan; Xu-Pei Huang


    Catdiomyopathies are diseases that primarily affect the myocardium,leading to serious cardiac dysfimction and heart failure.Out of the three major categories of candiomyopathies(hypertrophic,dilated and restrictive),restrictive cardiomyopathy(RCM)is less common and also the least studied However,the prognosis for RCM is poor as some patients dying in their childhood The molecular mechanisms behind the disease development and progression are not very clear and the treatment of RCM is very difficult and often ineffective.In this article,we reviewed the recent progress in RCM research from the clinical studies and the translational studies done on diseased transgenic animal models.This will help for a better understanding of tare mechanisms underlying the etiology and development of RCM and for the design of better treatments for the disease.

  20. Generating families in the restricted three-body problem

    Hénon, Michel

    The classical restricted three-body problem is of fundamental importance because of its applications in astronomy and space navigation, and also as a simple model of a non-integrable Hamiltonian dynamical system. A central role is played by periodic orbits, of which many have been computed numerically. This is the second volume of an attempt to explain and organize the material through a systematic study of generating families, the limits of families of periodic orbits when the mass ratio of the two main bodies becomes vanishingly small. We use quantitative analysis in the vicinity of bifurcations of types 1 and 2. In most cases the junctions between branches can now be determined. A first-order approximation of families of periodic orbits in the vicinity of a bifurcation is also obtained. This book is intended for scientists and students interested in the restricted problem, in its applications to astronomy and space research, and in the theory of dynamical systems.

  1. Identification of beef using restriction fragment length polymorphism–

    R. A. Al-Sanjary


    Full Text Available To differentiate the beef from other types of meat consumed by human, DNA markers based on polymerase chain reaction restriction fragment length polymorphism technique is performed by using universal primers designed on mitochondrial cytochrome b gene to obtain amplified band 359 bp, then digested with some of restriction enzymes like Tru91, RsaI, Hinf I, Hae III, Alu I, Taq I, Mob I. The result revealed that, the Hinf I enzyme produce three bands 198, 117, 44 bp and the Hae III enzyme revealed two band 285, 74 bp, the Alu I enzyme also produced two band but the molecular weight are 190, 169 bp. The other enzymes did not reveal any digestion of the amplified bands and this result is a characteristic unique to beef compared with other types of meat when using same enzymes.

  2. Why restrictions on the immigration of health workers are unjust.

    Hidalgo, Javier


    Some bioethicists and political philosophers argue that rich states should restrict the immigration of health workers from poor countries in order to prevent harm to people in these countries. In this essay, I argue that restrictions on the immigration of health workers are unjust, even if this immigration results in bad health outcomes for people in poor countries. I contend that negative duties to refrain from interfering with the occupational liberties of health workers outweighs rich states' positive duties to prevent harm to people in sending countries. Furthermore, I defend this claim against the objection that health workers in poor countries acquire special duties to their compatriots that render them liable to coercive interference.

  3. Cosmological Perturbations in Restricted f(R)-Gravity

    Chaichian, M; Kluson, J


    We investigate the metric perturbations of the restricted f(R) theory of gravity in the cosmological context and explore the phenomenological implications of this model. We show that it is possible to construct a restricted model of gravity, in which the background equations are the same as the equations of motion which are derived from the Einstein-Hilbert action with the cosmological constant term. We argue that the deviation from the Einstein-Hilbert model emerges in the perturbed equations, for which we have a non-vanishing anisotropic stress. Further, with the help of the results of Planck data for the modified gravity we obtain constraints on the parameters of the model.


    Sean C. Sweetman


    Full Text Available Over 500 drugs restricted in sport presented in alphabetical order. To inform and alert the athlete about the potential problem of drug taking for any kind of reasons on and off during training and competition.A comprehensive index of drug names, synonyms, medical usage, single and multi-ingredient preparations and trade (on occasion street names of drugs from 40 countries worldwide (Martindale data. The classification of World Anti-Doping Agency (WADA is added to the explanation of drugs limitation in sport in and out of competition. A glossary of common medical terms is also included.This pocket publication is a must-have list of restricted drugs for athletes, trainers, sports medicine professionals, in short for anyone in exercise physiology and human performance fields.


    Reinhard Hochmuth


    This paper studies several problems, which are potentially relevant for the construction of adaptive numerical schemes. First, biorthogonal spline wavelets on [0,1 ] are chosen as a starting point for characterizations of functions in Besov spaces B , (0,1) with 0<σ<∞ and (1+σ)-1<τ<∞. Such function spaces are known to be related to nonlinear approximation. Then so called restricted nonlinear approximation procedures with respect to Sobolev space norms are considered. Besides characterization results Jackson type estimates for various tree-type and tresholding algorithms are investigated. Finally known approximation results for geometry induced singularity functions of boundary integeral equations are combined with the characterization results for restricted nonlinear approximation to show Besov space regularity results.

  6. Non-placental causes of intrauterine growth restriction.

    Hendrix, Nancy; Berghella, Vincenzo


    Placental insufficiency, in some form or fashion, is associated with the majority of cases of intrauterine growth restriction (IUGR). There are numerous causes of IUGR which are not caused primarily by placental insufficiency, but indirectly lead to it. The causes of IUGR can be subdivided into fetal and maternal etiologies. The fetal etiologies consist of genetic diseases, congenital malformations, infections, multiple gestations, and placental/cord abnormalities. The maternal etiologies are categorized as follows: (1) decreased uteroplacental blood flow, (2) reduced blood volume, (3) decreased oxygen carrying capacity, (4) nutrition status, (5) teratogens, and (6) miscellaneous causes such as short interpregnancy intervals, race, maternal age, and low socioeconomic status. Knowledge of the etiologies of fetal growth restriction is essential, so that future care can be targeted at prevention. There are several primary and secondary prevention strategies that can be adopted.

  7. BST-2 mediated restriction of simian-human immunodeficiency virus.

    Ruiz, Autumn; Lau, David; Mitchell, Richard S; Hill, M Sarah; Schmitt, Kimberly; Guatelli, John C; Stephens, Edward B


    Pathogenic simian-human immunodeficiency viruses (SHIV) contain HIV-1 Vpu and SIV Nef, both shown to counteract BST-2 (HM1.24; CD317; tetherin) inhibition of virus release in a species-specific manner. We show that human and pig-tailed BST-2 (ptBST-2) restrict SHIV. We found that sequential "humanization" of the transmembrane domain (TMD) of the pig-tailed BST-2 (ptBST-2) protein resulted in a fluctuation in sensitivity to HIV-1 Vpu. Our results also show that the length of the TMD in human and ptBST-2 proteins is important for BST-2 restriction and susceptibility to Vpu. Taken together, our results emphasize the importance of tertiary structure in BST-2 antagonism and suggests that the HIV-1 Vpu transmembrane domain may have additional functions in vivo unrelated to BST-2 antagonism.

  8. Accelerated Monte Carlo simulations with restricted Boltzmann machines

    Huang, Li; Wang, Lei


    Despite their exceptional flexibility and popularity, Monte Carlo methods often suffer from slow mixing times for challenging statistical physics problems. We present a general strategy to overcome this difficulty by adopting ideas and techniques from the machine learning community. We fit the unnormalized probability of the physical model to a feed-forward neural network and reinterpret the architecture as a restricted Boltzmann machine. Then, exploiting its feature detection ability, we utilize the restricted Boltzmann machine to propose efficient Monte Carlo updates to speed up the simulation of the original physical system. We implement these ideas for the Falicov-Kimball model and demonstrate an improved acceptance ratio and autocorrelation time near the phase transition point.

  9. Accelerate Monte Carlo Simulations with Restricted Boltzmann Machines

    Huang, Li


    Despite their exceptional flexibility and popularity, the Monte Carlo methods often suffer from slow mixing times for challenging statistical physics problems. We present a general strategy to overcome this difficulty by adopting ideas and techniques from the machine learning community. We fit the unnormalized probability of the physical model to a feedforward neural network and reinterpret the architecture as a restricted Boltzmann machine. Then, exploiting its feature detection ability, we utilize the restricted Boltzmann machine for efficient Monte Carlo updates and to speed up the simulation of the original physical system. We implement these ideas for the Falicov-Kimball model and demonstrate improved acceptance ratio and autocorrelation time near the phase transition point.

  10. Effects of restriction on children’s intake differ by child temperament, food reinforcement, and parent’s chronic use of restriction.

    Rollins, Brandi Y; Loken, Eric; Savage, Jennifer S; Birch, Leann L


    Parents’ use of restrictive feeding practices is counterproductive, increasing children’s intake of restricted foods and risk for excessive weight gain. The aims of this research were to replicate Fisher and Birch’s (1999b) original findings that short-term restriction increases preschool children’s (3–5 y) selection, intake, and behavioral response to restricted foods, and to identify characteristics of children who were more susceptible to the negative effects of restriction. The experiment used a within-subjects design; 37 children completed the food reinforcement task and heights/weights were measured. Parents reported on their use of restrictive feeding practices and their child’s inhibitory control and approach. Overall, the findings replicated those of and revealed that the effects of restriction differed by children’s regulatory and appetitive tendencies. Greater increases in intake in response to restriction were observed among children lower in inhibitory control, higher in approach, who found the restricted food highly reinforcing, and who had previous experience with parental use of restriction. Results confirm that the use of restriction does not reduce children’s consumption of these foods, particularly among children with lower regulatory or higher appetitive tendencies.

  11. Effect of restriction of working memory on reported paranormal belief.

    Dudley, R T


    56 college students completed Tobacyk's 1988 Revised Paranormal Belief Scale and Watson, Clark, and Tellegen's 1988 Positive and Negative Affect Scale. Experimental group participants, but not control group participants, rehearsed a five-digit number while completing the Paranormal Belief Scale. Analysis showed higher reported paranormal belief for experimental group participants but no differences on the Positive and Negative Affect Scale. Results are discussed in terms of the effect of restriction in working memory on the critical evaluation of paranormal phenomena.

  12. Restrictions on running IRC (Internet Relay Chat) at CERN


    Due to the large number of computer security incidents at CERN where intruders have used IRC (Internet Relay Chat) software to control computers, IRC connections will be blocked in the CERN firewall from 1st February 2005. Personal use of IRC software is not permitted at CERN. Further details of the restrictions on both personal and professional use of IRC are documented at

  13. Transcriptional profiling of Actinobacillus pleuropneumoniae under iron-restricted conditions

    Harel Josée


    Full Text Available Abstract Background To better understand effects of iron restriction on Actinobacillus pleuropneumoniae and to identify new potential vaccine targets, we conducted transcript profiling studies using a DNA microarray containing all 2025 ORFs of the genome of A. pleuropneumoniae serotype 5b strain L20. This is the first study involving the use of microarray technology to monitor the transcriptome of A. pleuropneumoniae grown under iron restriction. Results Upon comparing growth of this pathogen in iron-sufficient versus iron-depleted medium, 210 genes were identified as being differentially expressed. Some genes (92 were identified as being up-regulated; many have confirmed or putative roles in iron acquisition, such as the genes coding for two TonB energy-transducing proteins and the hemoglobin receptor HgbA. Transcript profiling also led to identification of some new iron acquisition systems of A. pleuropneumoniae. Genes coding for a possible Yfe system (yfeABCD, implicated in the acquisition of chelated iron, were detected, as well as genes coding for a putative enterobactin-type siderophore receptor system. ORFs for homologs of the HmbR system of Neisseria meningitidis involved in iron acquisition from hemoglobin were significantly up-regulated. Down-regulated genes included many that encode proteins containing Fe-S clusters or that use heme as a cofactor. Supplementation of the culture medium with exogenous iron re-established the expression level of these genes. Conclusion We have used transcriptional profiling to generate a list of genes showing differential expression during iron restriction. This strategy enabled us to gain a better understanding of the metabolic changes occurring in response to this stress. Many new potential iron acquisition systems were identified, and further studies will have to be conducted to establish their role during iron restriction.

  14. Revised selection criteria for candidate restriction enzymes in genome walking.

    Taheri, Ali; Robinson, Stephen J; Parkin, Isobel; Gruber, Margaret Y


    A new method to improve the efficiency of flanking sequence identification by genome walking was developed based on an expanded, sequential list of criteria for selecting candidate enzymes, plus several other optimization steps. These criteria include: step (1) initially choosing the most appropriate restriction enzyme according to the average fragment size produced by each enzyme determined using in silico digestion of genomic DNA, step (2) evaluating the in silico frequency of fragment size distribution between individual chromosomes, step (3) selecting those enzymes that generate fragments with the majority between 100 bp and 3,000 bp, step (4) weighing the advantages and disadvantages of blunt-end sites vs. cohesive-end sites, step (5) elimination of methylation sensitive enzymes with methylation-insensitive isoschizomers, and step (6) elimination of enzymes with recognition sites within the binary vector sequence (T-DNA and plasmid backbone). Step (7) includes the selection of a second restriction enzyme with highest number of recognition sites within regions not covered by the first restriction enzyme. Step (8) considers primer and adapter sequence optimization, selecting the best adapter-primer pairs according to their hairpin/dimers and secondary structure. In step (9), the efficiency of genomic library development was improved by column-filtration of digested DNA to remove restriction enzyme and phosphatase enzyme, and most important, to remove small genomic fragments (enzymes, NsiI and NdeI, fit these criteria for the Arabidopsis thaliana genome. Their efficiency was assessed using 54 T(3) lines from an Arabidopsis SK enhancer population. Over 70% success rate was achieved in amplifying the flanking sequences of these lines. This strategy was also tested with Brachypodium distachyon to demonstrate its applicability to other larger genomes.

  15. Semantic congruence reverses effects of sleep restriction on associative encoding.

    Alberca-Reina, Esther; Cantero, Jose L; Atienza, Mercedes


    Encoding and memory consolidation are influenced by factors such as sleep and congruency of newly learned information with prior knowledge (i.e., schema). However, only a few studies have examined the contribution of sleep to enhancement of schema-dependent memory. Based on previous studies showing that total sleep deprivation specifically impairs hippocampal encoding, and that coherent schemas reduce the hippocampal consolidation period after learning, we predict that sleep loss in the pre-training night will mainly affect schema-unrelated information whereas sleep restriction in the post-training night will have similar effects on schema-related and unrelated information. Here, we tested this hypothesis by presenting participants with face-face associations that could be semantically related or unrelated under different sleep conditions: normal sleep before and after training, and acute sleep restriction either before or after training. Memory was tested one day after training, just after introducing an interference task, and two days later, without any interference. Significant results were evident on the second retesting session. In particular, sleep restriction before training enhanced memory for semantically congruent events in detriment of memory for unrelated events, supporting the specific role of sleep in hippocampal memory encoding. Unexpectedly, sleep restriction after training enhanced memory for both related and unrelated events. Although this finding may suggest a poorer encoding during the interference task, this hypothesis should be specifically tested in future experiments. All together, the present results support a framework in which encoding processes seem to be more vulnerable to sleep loss than consolidation processes.

  16. Efficacy, Safety and Mechanisms of Blood Flow Restricted Exercise

    Ploutz-Snyder, Lori


    This 20 minute talk will review studies in the peer-reviewed literature related to the effectiveness of blood flow restricted exercise as an exercise training program. There is controversy regarding the talk with cover the effectiveness of various exercise protocols and these differences will be compared and contrasted. Unpublished data from my laboratory at Syracuse University will be presented (see other abstract), as well as some unpublished work from the labs of Manini, Clark and Rasmussen (none are NASA funded).


    A.Aziz; W.M.Shah


    LetP(Z)=αn Zn + αn-1Zn-1 +…+α0 be a complex polynomial of degree n. There is a close connection between the coefficients and the zeros of P(z). In this paper we prove some sharp inequalities concerning the coeffi-cients of the polynomial P(z) with restricted zeros. We also establish a sufficient condition for the separation of zeros of P(z).

  18. Differential diagnosis of restricted diffusion confined to the cerebral cortex

    Sheerin, F. [Department of Radiology, Stoke Mandeville Hospital (United Kingdom); Department of Neuroradiology, West Wing, John Radclife Hospital, Oxford OX3 9DU (United Kingdom)], E-mail:; Pretorius, P.M. [Department of Neuroradiology, West Wing, John Radclife Hospital, Oxford OX3 9DU (United Kingdom); Briley, D. [Department of Neurology, West Wing, John Radcliffe Hospital, Oxford (United Kingdom); Meagher, T. [Department of Radiology, Stoke Mandeville Hospital (United Kingdom)


    Diffusion-weighted MRI (DWI) has become increasingly widely available over recent years and is recognized as a powerful tool in neuroimaging. It is primarily used to identify acute ischaemia in patients presenting with stroke because of the improved sensitivity it offers early in the course of the disease. DWI also contributes useful diagnostic information in a range of other conditions. In this review we describe the magnetic resonance imaging (MRI) features of a number of conditions characterized by cortical diffusion restriction (CDR)

  19. Troponin Ⅰ,cardiac diastolic dysfunction and restrictive cardiomyopathy

    Xu-pei HUANG; Jian-feng DU


    Cardiomyopathies are diseases of heart muscle that are associated with cardiac dysfunction. Molecular genetic studies performed to date have demonstrated that the damage or mutations in several sarcomeric contractile protein genes are associated with the development of the diseases. In this review, cardiac troponin Ⅰ, one of the sarcomeric thin filament protein, will be discussed regarding its role in cardiac function, its deficiency-related diastolic dysfunction, and the mutation of this protein-mediated restrictive cardiomyopathy.

  20. Does globalization restrict budgetary autonomy? A multidimensional approach

    Heinemann, Friedrich


    Does globalization restrict the leeway for national budgetary policy? With the help of cluster and discriminant analysis this study provides evidence on the basis of the experience of OECD countries since the 1970s. Four budgetary dimensions are included in the analysis: tax structure, expenditure structure, public debt and budget size. Globalization as a potential driving force for changes in government finance is identified in form of variables on the existence of capital and current accoun...

  1. The Restriction .on Educational Quality in Rural Schools



    In order to understand the educational quality in rural schools, I went deep into Huangjia Middle School( situated in Northern China) to make the research. In this article, I focus on the restrictions on educational qualitys, which is one of the main themes about rural education. The factors influencing quality in rural schools are analyzed in this article .It is concluded that educational quality depends on the relationship of teaching and learning and its supporting context.

  2. Book review: Sexuality in Muslim contexts: restrictions and resistance

    Mason, Olivia


    "Sexuality in Muslim Contexts: Restrictions and Resistance." Anissa Helie and Homa Hoodfar (eds). Zed Books. October 2012. --- Using case studies from Pakistan, Iran, Indonesia, China, Bangladesh, Israel and India, Sexuality in Muslim Contexts argues that Muslim religious traditions do not necessarily lead to conservative agendas but can promote emancipatory standpoints. Olivia Mason thinks however you currently understand sexuality in Muslim contexts this book will definitely change it fo...

  3. Cytosine methylation dysregulation in neonates following intrauterine growth restriction.

    Francine Einstein

    Full Text Available BACKGROUND: Perturbations of the intrauterine environment can affect fetal development during critical periods of plasticity, and can increase susceptibility to a number of age-related diseases (e.g., type 2 diabetes mellitus; T2DM, manifesting as late as decades later. We hypothesized that this biological memory is mediated by permanent alterations of the epigenome in stem cell populations, and focused our studies specifically on DNA methylation in CD34+ hematopoietic stem and progenitor cells from cord blood from neonates with intrauterine growth restriction (IUGR and control subjects. METHODS AND FINDINGS: Our epigenomic assays utilized a two-stage design involving genome-wide discovery followed by quantitative, single-locus validation. We found that changes in cytosine methylation occur in response to IUGR of moderate degree and involving a restricted number of loci. We also identify specific loci that are targeted for dysregulation of DNA methylation, in particular the hepatocyte nuclear factor 4alpha (HNF4A gene, a well-known diabetes candidate gene not previously associated with growth restriction in utero, and other loci encoding HNF4A-interacting proteins. CONCLUSIONS: Our results give insights into the potential contribution of epigenomic dysregulation in mediating the long-term consequences of IUGR, and demonstrate the value of this approach to studies of the fetal origin of adult disease.

  4. Mechanisms and efficacy of dietary FODMAP restriction in IBS.

    Staudacher, Heidi M; Irving, Peter M; Lomer, Miranda C E; Whelan, Kevin


    IBS is a debilitating condition that markedly affects quality of life. The chronic nature, high prevalence and associated comorbidities contribute to the considerable economic burden of IBS. The pathophysiology of IBS is not completely understood and evidence to guide management is variable. Interest in dietary intervention continues to grow rapidly. Ileostomy and MRI studies have demonstrated that some fermentable carbohydrates increase ileal luminal water content and breath hydrogen testing studies have demonstrated that some carbohydrates also increase colonic hydrogen production. The effects of fermentable carbohydrates on gastrointestinal symptoms have also been well described in blinded, controlled trials. Dietary restriction of fermentable carbohydrates (popularly termed the 'low FODMAP diet') has received considerable attention. An emerging body of research now demonstrates the efficacy of fermentable carbohydrate restriction in IBS; however, limitations still exist with this approach owing to a limited number of randomized trials, in part due to the fundamental difficulty of placebo control in dietary trials. Evidence also indicates that the diet can influence the gut microbiota and nutrient intake. Fermentable carbohydrate restriction in people with IBS is promising, but the effects on gastrointestinal health require further investigation.

  5. Restricted numerical shadow and geometry of quantum entanglement

    Puchała, Zbigniew; Gawron, Piotr; Dunkl, Charles F; Holbrook, John A; Życzkowski, Karol


    The restricted numerical range W_R(A) of an operator A acting on a D-dimensional Hilbert space is defined as a set of all possible expectation values of this operator among pure states which belong to a certain subset R of the of set of pure quantum states of dimension D. One considers for instance the set of real states, or in the case of composite spaces, the set of product states and the set of maximally entangled states. Combining the operator theory with a probabilistic approach we introduce the restricted numerical shadow of A -- a normalized probability distribution on the complex plane supported in W_R(A). Its value at point z in C is equal to the probability that the expectation value is equal to z, where |\\psi> represents a random quantum state in subset R distributed according to the natural measure on this set, induced by the unitarily invariant Fubini--Study measure. Studying restricted shadows of operators of a fixed size D=N_A N_B we analyse the geometry of sets of separable and maximally enta...

  6. Type III restriction-modification enzymes: a historical perspective.

    Rao, Desirazu N; Dryden, David T F; Bheemanaik, Shivakumara


    Restriction endonucleases interact with DNA at specific sites leading to cleavage of DNA. Bacterial DNA is protected from restriction endonuclease cleavage by modifying the DNA using a DNA methyltransferase. Based on their molecular structure, sequence recognition, cleavage position and cofactor requirements, restriction-modification (R-M) systems are classified into four groups. Type III R-M enzymes need to interact with two separate unmethylated DNA sequences in inversely repeated head-to-head orientations for efficient cleavage to occur at a defined location (25-27 bp downstream of one of the recognition sites). Like the Type I R-M enzymes, Type III R-M enzymes possess a sequence-specific ATPase activity for DNA cleavage. ATP hydrolysis is required for the long-distance communication between the sites before cleavage. Different models, based on 1D diffusion and/or 3D-DNA looping, exist to explain how the long-distance interaction between the two recognition sites takes place. Type III R-M systems are found in most sequenced bacteria. Genome sequencing of many pathogenic bacteria also shows the presence of a number of phase-variable Type III R-M systems, which play a role in virulence. A growing number of these enzymes are being subjected to biochemical and genetic studies, which, when combined with ongoing structural analyses, promise to provide details for mechanisms of DNA recognition and catalysis.

  7. Restricted common data in anonymous E-cash system

    ZHANG Xiang-jun; CHEN Ke-fei


    Discuss the problem of infinite increasing coin list in anonymous E-cash systems, which reduce the efficiency of whole system greatly. Though some methods are suggested, no one can solve the problem with high efficiency and flexibility. Here, we use the technique of adding information in blind signatures to deal with this problem. Through adding timestamp in signatures, we can separate the valid period of all used coins into pieces. Only the coins in the last stage are recorded. So the scale of the coins list is controlled. We also analyze the anonymity of these data, and add some indispensable restrictions to them. These restrictions can ensure that the imported data don't break the anonymity of the customers. In order to fulfill these qualifications, we lead to the concept of restricted common data (RCD). Furthermore, we propose two schemes to add RCD in the blind signature. The simple one is easy to implement, while the complex one can note the value of the coin. The usage of RCD leads to little additional cost, as well as maintaining the anonymity of customers. This method fits for most kinds of anonymous E-cash systems.

  8. A randomized trial of dietary sodium restriction in CKD.

    McMahon, Emma J; Bauer, Judith D; Hawley, Carmel M; Isbel, Nicole M; Stowasser, Michael; Johnson, David W; Campbell, Katrina L


    There is a paucity of quality evidence regarding the effects of sodium restriction in patients with CKD, particularly in patients with pre-end stage CKD, where controlling modifiable risk factors may be especially important for delaying CKD progression and cardiovascular events. We conducted a double-blind placebo-controlled randomized crossover trial assessing the effects of high versus low sodium intake on ambulatory BP, 24-hour protein and albumin excretion, fluid status (body composition monitor), renin and aldosterone levels, and arterial stiffness (pulse wave velocity and augmentation index) in 20 adult patients with hypertensive stage 3-4 CKD as phase 1 of the LowSALT CKD study. Overall, salt restriction resulted in statistically significant and clinically important reductions in BP (mean reduction of systolic/diastolic BP, 10/4 mm Hg; 95% confidence interval, 5 to 15 /1 to 6 mm Hg), extracellular fluid volume, albuminuria, and proteinuria in patients with moderate-to-severe CKD. The magnitude of change was more pronounced than the magnitude reported in patients without CKD, suggesting that patients with CKD are particularly salt sensitive. Although studies with longer intervention times and larger sample sizes are needed to confirm these benefits, this study indicates that sodium restriction should be emphasized in the management of patients with CKD as a means to reduce cardiovascular risk and risk for CKD progression.

  9. Hanford land disposal restrictions plan for mixed wastes


    Since the early 1940s, the Hanford Site has been involved in the production and purification of nuclear defense materials. These production activities have resulted in the generation of large quantities of liquid and solid radioactive mixed waste. This waste is subject to regulation under authority of both the Resource Conservation and Recovery Act of 1976 (RCRA) and the Atomic Energy Act. The State of Washington Department of Ecology (Ecology), the US Environmental Protection Agency (EPA), and the US Department of Energy (DOE) have entered into an agreement, the Hanford Federal Facility Agreement and Consent Order (Tri-Party Agreement) to bring Hanford Site Operations into compliance with dangerous waste regulations. The Tri-Party Agreement was amended to require development of the Hanford Land Disposal Restrictions Plan for Mixed Wastes (this plan) to comply with land disposal restrictions requirements for radioactive mixed waste. The Tri-Party Agreement requires, and the this plan provides, the following sections: Waste Characterization Plan, Storage Report, Treatment Report, Treatment Plan, Waste Minimization Plan, a schedule, depicting the events necessary to achieve full compliance with land disposal restriction requirements, and a process for establishing interim milestones. 34 refs., 28 figs., 35 tabs.

  10. Learning restricted Boolean network model by time-series data.

    Ouyang, Hongjia; Fang, Jie; Shen, Liangzhong; Dougherty, Edward R; Liu, Wenbin


    Restricted Boolean networks are simplified Boolean networks that are required for either negative or positive regulations between genes. Higa et al. (BMC Proc 5:S5, 2011) proposed a three-rule algorithm to infer a restricted Boolean network from time-series data. However, the algorithm suffers from a major drawback, namely, it is very sensitive to noise. In this paper, we systematically analyze the regulatory relationships between genes based on the state switch of the target gene and propose an algorithm with which restricted Boolean networks may be inferred from time-series data. We compare the proposed algorithm with the three-rule algorithm and the best-fit algorithm based on both synthetic networks and a well-studied budding yeast cell cycle network. The performance of the algorithms is evaluated by three distance metrics: the normalized-edge Hamming distance [Formula: see text], the normalized Hamming distance of state transition [Formula: see text], and the steady-state distribution distance μ (ssd). Results show that the proposed algorithm outperforms the others according to both [Formula: see text] and [Formula: see text], whereas its performance according to μ (ssd) is intermediate between best-fit and the three-rule algorithms. Thus, our new algorithm is more appropriate for inferring interactions between genes from time-series data.

  11. Comprehensive tobacco marketing restrictions: promotion, packaging, price and place.

    Henriksen, Lisa


    Evidence of the causal role of marketing in the tobacco epidemic and the advent of the WHO Framework Convention on Tobacco Control have inspired more than half the countries in the world to ban some forms of tobacco marketing. This paper briefly describes the ways in which cigarette marketing is restricted and the tobacco industry's efforts to subvert restrictions. It reviews what is known about the impact of marketing regulations on smoking by adults and adolescents. It also addresses what little is known about the impact of marketing bans in relation to concurrent population-level interventions, such as price controls, anti-tobacco media campaigns and smoke-free laws. Point of sale is the least regulated channel and research is needed to address the immediate and long-term consequences of policies to ban retail advertising and pack displays. Comprehensive marketing restrictions require a global ban on all forms of promotion, elimination of packaging and price as marketing tools, and limitations on the quantity, type and location of tobacco retailers.

  12. A cohomology theory of grading-restricted vertex algebras

    Huang, Yi-Zhi


    We introduce a cohomology theory of grading-restricted vertex algebras. To construct the "correct" cohomologies, we consider linear maps from tensor powers of a grading-restricted vertex algebra to "rational functions valued in the algebraic completion of a module for the algebra," instead of linear maps from tensor powers of the algebra to a module for the algebra. One subtle complication arising from such "rational functions valued in the algebraic completion of a module" is that we have to carefully address the issue of convergence when we compose these linear maps with vertex operators. In particular, for each $n\\in \\N$, we have an inverse system $\\{H^{n}_{m}(V, W)\\}_{m\\in \\Z_{+}}$ of $n$-th cohomologies and an additional $n$-th cohomology $H_{\\infty}^{n}(V, W)$ of a grading-restricted vertex algebra $V$ with coefficients in a $V$-module $W$ such that $H_{\\infty}^{n}(V, W)$ is isomorphic to the inverse limit of the inverse system $\\{H^{n}_{m}(V, W)\\}_{m\\in \\Z_{+}}$. In the case of $n=2$, there is an addit...

  13. Learning restricted Boolean network model by time-series data


    Restricted Boolean networks are simplified Boolean networks that are required for either negative or positive regulations between genes. Higa et al. (BMC Proc 5:S5, 2011) proposed a three-rule algorithm to infer a restricted Boolean network from time-series data. However, the algorithm suffers from a major drawback, namely, it is very sensitive to noise. In this paper, we systematically analyze the regulatory relationships between genes based on the state switch of the target gene and propose an algorithm with which restricted Boolean networks may be inferred from time-series data. We compare the proposed algorithm with the three-rule algorithm and the best-fit algorithm based on both synthetic networks and a well-studied budding yeast cell cycle network. The performance of the algorithms is evaluated by three distance metrics: the normalized-edge Hamming distance μhame, the normalized Hamming distance of state transition μhamst, and the steady-state distribution distance μssd. Results show that the proposed algorithm outperforms the others according to both μhame and μhamst, whereas its performance according to μssd is intermediate between best-fit and the three-rule algorithms. Thus, our new algorithm is more appropriate for inferring interactions between genes from time-series data. PMID:25093019

  14. Fasting and Caloric Restriction in Cancer Prevention and Treatment.

    Brandhorst, Sebastian; Longo, Valter D

    Cancer is the second leading cause of death in the USA and among the leading major diseases in the world. It is anticipated to continue to increase because of the growth of the aging population and prevalence of risk factors such as obesity, smoking, and/or poor dietary habits. Cancer treatment has remained relatively similar during the past 30 years with chemotherapy and/or radiotherapy in combination with surgery remaining the standard therapies although novel therapies are slowly replacing or complementing the standard ones. According to the American Cancer Society, the dietary recommendation for cancer patients receiving chemotherapy is to increase calorie and protein intake. In addition, there are no clear guidelines on the type of nutrition that could have a major impact on cancer incidence. Yet, various forms of reduced caloric intake such as calorie restriction (CR) or fasting demonstrate a wide range of beneficial effects able to help prevent malignancies and increase the efficacy of cancer therapies. Whereas chronic CR provides both beneficial and detrimental effects as well as major compliance challenges, periodic fasting (PF), fasting-mimicking diets (FMDs), and dietary restriction (DR) without a reduction in calories are emerging as interventions with the potential to be widely used to prevent and treat cancer. Here, we review preclinical and preliminary clinical studies on dietary restriction and fasting and their role in inducing cellular protection and chemotherapy resistance.


    Lyatsa A. Kodzokova


    Full Text Available Abstract: The article considers the restrictions imposed on the circulation of civilian and service weapons. The author analyzes the restrictions on the circulation of weapons, the procedure for their implementation in practice. Federal Law "On weapons" only in paragraph 6 p. 1, art. 6 "Restrictions imposed on the circulation of civilian and service weapons" refers to the prohibition of 'turnover as a civilian and service weapons and other items affecting the action is based on the use of radiation and biological factors; weapons and other items affecting the action is based on the use of electromagnetic, light, thermal, subsonic or ultrasonic radiation and which have output parameters that exceed the value set by state standards of the Russian Federation and the relevant regulations of the federal executive authority in the field of public health, as well as these weapons and items produced outside the Russian territory " How to regard this provision of the law? As the transfer of new weapons, not specific item. 25 of the Federal Law "On weapons", or items prohibited for circulation in the territory of our state? This inconsistency decreases the effectiveness of the legal regulation of arms trafficking. Unification of definitions in this area will allow applying the law correctly and reasonably, including criminal. But for this it is necessary taking into account the experience and the modern needs of the various branches of law provide a clearer definition of "weapon" and its species. The author's conclusions may be used in law enforcement. 

  16. Heart Morphometry in Rats with Intrauterine Growth Restriction

    Claudia Joffre Fríaz


    Full Text Available Background: epidemiological and experimental studies suggest that cardiovascular disease in adulthood is influenced by prenatal or early postnatal events, regardless of lifestyle-related risk factors. Objective: to characterize the heart morphometry in Wistar rats with intrauterine growth restriction and to determine the differences between adolescents and adults of both sexes as well as the association with some morphometric variables at birth. Methods: a total of 80 rats in the control group and 80 in the experimental group were studied. The following morphometric variables were analyzed in the newborns: weight, height in addition to size, weight and volume of the heart, all in millimeters. Results: low birth weight resulting from intrauterine growth restriction caused changes in heart morphometry, especially in heart weight and thickness of the left ventricle. These changes were observed in both sexes during adolescence and showed a slight predominance in adult males. Conclusions: these results led to an increased knowledge of the events involved in heart development in response to nutrient restriction in utero, which could contribute to the design of health strategies to reduce morbidity and perinatal mortality from heart diseases.

  17. Calorie restriction increases muscle mitochondrial biogenesis in healthy humans.

    Anthony E Civitarese


    Full Text Available BACKGROUND: Caloric restriction without malnutrition extends life span in a range of organisms including insects and mammals and lowers free radical production by the mitochondria. However, the mechanism responsible for this adaptation are poorly understood. METHODS AND FINDINGS: The current study was undertaken to examine muscle mitochondrial bioenergetics in response to caloric restriction alone or in combination with exercise in 36 young (36.8 +/- 1.0 y, overweight (body mass index, 27.8 +/- 0.7 kg/m(2 individuals randomized into one of three groups for a 6-mo intervention: Control, 100% of energy requirements; CR, 25% caloric restriction; and CREX, caloric restriction with exercise (CREX, 12.5% CR + 12.5% increased energy expenditure (EE. In the controls, 24-h EE was unchanged, but in CR and CREX it was significantly reduced from baseline even after adjustment for the loss of metabolic mass (CR, -135 +/- 42 kcal/d, p = 0.002 and CREX, -117 +/- 52 kcal/d, p = 0.008. Participants in the CR and CREX groups had increased expression of genes encoding proteins involved in mitochondrial function such as PPARGC1A, TFAM, eNOS, SIRT1, and PARL (all, p < 0.05. In parallel, mitochondrial DNA content increased by 35% +/- 5% in the CR group (p = 0.005 and 21% +/- 4% in the CREX group (p < 0.004, with no change in the control group (2% +/- 2%. However, the activity of key mitochondrial enzymes of the TCA (tricarboxylic acid cycle (citrate synthase, beta-oxidation (beta-hydroxyacyl-CoA dehydrogenase, and electron transport chain (cytochrome C oxidase II was unchanged. DNA damage was reduced from baseline in the CR (-0.56 +/- 0.11 arbitrary units, p = 0.003 and CREX (-0.45 +/- 0.12 arbitrary units, p = 0.011, but not in the controls. In primary cultures of human myotubes, a nitric oxide donor (mimicking eNOS signaling induced mitochondrial biogenesis but failed to induce SIRT1 protein expression, suggesting that additional factors may regulate SIRT1 content

  18. Restriction enzyme body doubles and PCR cloning: on the general use of type IIs restriction enzymes for cloning.

    Tóth, Eszter; Huszár, Krisztina; Bencsura, Petra; Kulcsár, Péter István; Vodicska, Barbara; Nyeste, Antal; Welker, Zsombor; Tóth, Szilvia; Welker, Ervin


    The procedure described here allows the cloning of PCR fragments containing a recognition site of the restriction endonuclease (Type IIP) used for cloning in the sequence of the insert. A Type IIS endonuclease--a Body Double of the Type IIP enzyme--is used to generate the same protruding palindrome. Thus, the insert can be cloned to the Type IIP site of the vector without digesting the PCR product with the same Type IIP enzyme. We achieve this by incorporating the recognition site of a Type IIS restriction enzyme that cleaves the DNA outside of its recognition site in the PCR primer in such a way that the cutting positions straddle the desired overhang sequence. Digestion of the PCR product by the Body Double generates the required overhang. Hitherto the use of Type IIS restriction enzymes in cloning reactions has only been used for special applications, the approach presented here makes Type IIS enzymes as useful as Type IIP enzymes for general cloning purposes. To assist in finding Body Double enzymes, we summarised the available Type IIS enzymes which are potentially useful for Body Double cloning and created an online program ( for the selection of suitable Body Double enzymes and the design of the appropriate primers.

  19. Simple and rapid human papillomavirus genotyping method by restriction fragment length polymorphism analysis with two restriction enzymes.

    Chen, Linghan; Watanabe, Ken; Haruyama, Takahiro; Kobayashi, Nobuyuki


    Cervical cancer, the third most common cancer that affects women worldwide, is caused by the human papillomavirus (HPV) and is treatable when detected at an early stage. To date, more than 100 different HPV types have been described, and the development of simple, low-cost, and accurate methods to distinguish HPV genotypes is highly warranted. In this study, an HPV genotyping assay based on polymerase chain reaction (PCR) was evaluated. This method involved the use of MY09/11 primers followed by restriction fragment length polymorphism (RFLP) analysis with the restriction enzymes HpyCH4V and NlaIII. Cervical specimens preserved using CytoRich Blue fluid were collected from 1,134 female volunteers for HPV detection, and 1,111 valid samples were amplified using PCR. The PCR method was sensitive enough to detect 25 copies of HPV18, and three copies of HPV16. Out of 202 PCR-positive samples, HPV genotypes were determined in 189 samples (93.6%) by this RFLP method. Results were then evaluated further by capillary sequencing method. Concordant results between the two tests were as high as 96.0%. Thirteen samples, which tested negative with RFLP, were verified as non-specific amplifications with PCR. In conclusion, this PCR-RFLP method using restriction enzymes HpyCH4V and NlaIII is simple, non-labor intensive, and is applicable for the inexpensive determination of HPV genotypes in clinical samples.

  20. Restrictive Eating in Anorexia Nervosa: Examining Maintenance and Consequences in the Natural Environment

    Fitzsimmons-Craft, Ellen E.; Accurso, Erin C.; Ciao, Anna C.; Crosby, Ross D.; Cao, Li; Pisetsky, Emily M.; Le Grange, Daniel; Peterson, Carol B.; Crow, Scott J.; Engel, Scott G.; Mitchell, James E.; Wonderlich, Stephen A.


    Objective This study examined negative and positive affect in relation to restrictive eating episodes (i.e., meals/snacks perceived as restrictive) and whether restrictive eating was associated with likelihood of subsequent eating disorder behaviors (i.e., additional restrictive eating, binge eating, vomiting, laxative use, weighing, exercising, meal skipping, drinking fluids to curb appetite, body checking). Method Women with anorexia nervosa (N = 118) completed a two-week ecological momentary assessment protocol. Results For both restrictive and non-restrictive eating, negative affect significantly increased from pre-behavior to the time of the behavior but remained stable thereafter, while positive affect remained stable from pre-behavior to the time of the behavior but decreased significantly thereafter. Across time, negative affect was significantly lower and positive affect was significantly greater in restrictive than non-restrictive episodes. Engagement in restrictive eating was associated with an increased likelihood of subsequent restrictive eating, laxative use, and body checking, but not other behaviors. Engagement in non-restrictive eating was associated with a decreased likelihood of subsequent restrictive eating, binge eating, vomiting, laxative use, weighing, meal skipping, drinking fluids to curb appetite, and body checking. Discussion Despite similar patterns of affect across eating episodes over time, results suggest affect may be involved in the maintenance of restrictive eating in anorexia nervosa since restrictive episodes were associated with lower negative and greater positive affect across time compared to non-restrictive episodes. Further, while restrictive episodes increased the likelihood of only three subsequent eating disorder behaviors, non-restrictive episodes were protective since they decreased likelihood of all but one behavior. PMID:26310991

  1. Carbohydrate restriction improves the features of Metabolic Syndrome. Metabolic Syndrome may be defined by the response to carbohydrate restriction

    Feinman Richard D


    Full Text Available Abstract Metabolic Syndrome (MetS represents a constellation of markers that indicates a predisposition to diabetes, cardiovascular disease and other pathologic states. The definition and treatment are a matter of current debate and there is not general agreement on a precise definition or, to some extent, whether the designation provides more information than the individual components. We consider here five indicators that are central to most definitions and we provide evidence from the literature that these are precisely the symptoms that respond to reduction in dietary carbohydrate (CHO. Carbohydrate restriction is one of several strategies for reducing body mass but even in the absence of weight loss or in comparison with low fat alternatives, CHO restriction is effective at ameliorating high fasting glucose and insulin, high plasma triglycerides (TAG, low HDL and high blood pressure. In addition, low fat, high CHO diets have long been known to raise TAG, lower HDL and, in the absence of weight loss, may worsen glycemic control. Thus, whereas there are numerous strategies for weight loss, a patient with high BMI and high TAG is likely to benefit most from a regimen that reduces CHO intake. Reviewing the literature, benefits of CHO restriction are seen in normal or overweight individuals, in normal patients who meet the criteria for MetS or in patients with frank diabetes. Moreover, in low fat studies that ameliorate LDL and total cholesterol, controls may do better on the symptoms of MetS. On this basis, we feel that MetS is a meaningful, useful phenomenon and may, in fact, be operationally defined as the set of markers that responds to CHO restriction. Insofar as this is an accurate characterization it is likely the result of the effect of dietary CHO on insulin metabolism. Glucose is the major insulin secretagogue and insulin resistance has been tied to the hyperinsulinemic state or the effect of such a state on lipid metabolism. The

  2. Carbohydrate restriction improves the features of Metabolic Syndrome. Metabolic Syndrome may be defined by the response to carbohydrate restriction.

    Volek, Jeff S; Feinman, Richard D


    Metabolic Syndrome (MetS) represents a constellation of markers that indicates a predisposition to diabetes, cardiovascular disease and other pathologic states. The definition and treatment are a matter of current debate and there is not general agreement on a precise definition or, to some extent, whether the designation provides more information than the individual components. We consider here five indicators that are central to most definitions and we provide evidence from the literature that these are precisely the symptoms that respond to reduction in dietary carbohydrate (CHO). Carbohydrate restriction is one of several strategies for reducing body mass but even in the absence of weight loss or in comparison with low fat alternatives, CHO restriction is effective at ameliorating high fasting glucose and insulin, high plasma triglycerides (TAG), low HDL and high blood pressure. In addition, low fat, high CHO diets have long been known to raise TAG, lower HDL and, in the absence of weight loss, may worsen glycemic control. Thus, whereas there are numerous strategies for weight loss, a patient with high BMI and high TAG is likely to benefit most from a regimen that reduces CHO intake. Reviewing the literature, benefits of CHO restriction are seen in normal or overweight individuals, in normal patients who meet the criteria for MetS or in patients with frank diabetes. Moreover, in low fat studies that ameliorate LDL and total cholesterol, controls may do better on the symptoms of MetS. On this basis, we feel that MetS is a meaningful, useful phenomenon and may, in fact, be operationally defined as the set of markers that responds to CHO restriction. Insofar as this is an accurate characterization it is likely the result of the effect of dietary CHO on insulin metabolism. Glucose is the major insulin secretagogue and insulin resistance has been tied to the hyperinsulinemic state or the effect of such a state on lipid metabolism. The conclusion is probably not

  3. Metabolomics of dietary fatty acid restriction in patients with phenylketonuria.

    Ulrike Mütze

    Full Text Available BACKGROUND: Patients with phenylketonuria (PKU have to follow a lifelong phenylalanine restricted diet. This type of diet markedly reduces the intake of saturated and unsaturated fatty acids especially long chain polyunsaturated fatty acids (LC-PUFA. Long-chain saturated fatty acids are substrates of mitochondrial fatty acid oxidation for acetyl-CoA production. LC-PUFA are discussed to affect inflammatory and haemostaseological processes in health and disease. The influence of the long term PKU diet on fatty acid metabolism with a special focus on platelet eicosanoid metabolism has been investigated in the study presented here. METHODOLOGY/PRINCIPAL FINDINGS: 12 children with PKU under good metabolic control and 8 healthy controls were included. Activated fatty acids (acylcarnitines C6-C18 in dried blood and the cholesterol metabolism in serum were analyzed by liquid chromatographic tandem mass spectrometry (LC-MS/MS. Fatty acid composition of plasma glycerophospholipids was determined by gas chromatography. LC-PUFA metabolites were analyzed in supernatants by LC-MS/MS before and after platelet activation and aggregation using a standardized protocol. Patients with PKU had significantly lower free carnitine and lower activated fatty acids in dried blood compared to controls. Phytosterols as marker of cholesterol (re- absorption were not influenced by the dietary fatty acid restriction. Fatty acid composition in glycerophospholipids was comparable to that of healthy controls. However, patients with PKU showed significantly increased concentrations of y-linolenic acid (C18:3n-6 a precursor of arachidonic acid. In the PKU patients significantly higher platelet counts were observed. After activation with collagen platelet aggregation and thromboxane B(2 and thromboxane B(3 release did not differ from that of healthy controls. CONCLUSION/SIGNIFICANCE: Long-term dietary fatty acid restriction influenced the intermediates of mitochondrial beta

  4. Stepsize Restrictions for Boundedness and Monotonicity of Multistep Methods

    Hundsdorfer, W.


    In this paper nonlinear monotonicity and boundedness properties are analyzed for linear multistep methods. We focus on methods which satisfy a weaker boundedness condition than strict monotonicity for arbitrary starting values. In this way, many linear multistep methods of practical interest are included in the theory. Moreover, it will be shown that for such methods monotonicity can still be valid with suitable Runge-Kutta starting procedures. Restrictions on the stepsizes are derived that are not only sufficient but also necessary for these boundedness and monotonicity properties. © 2011 Springer Science+Business Media, LLC.

  5. [Maternal cannabis use and intra-uterine growth restriction].

    Davitian, C; Uzan, M; Tigaizin, A; Ducarme, G; Dauphin, H; Poncelet, C


    Marijuana is the most commonly used illegal drug, especially among young women in Western societies. The effects of cannabis use during pregnancy have been studied for many years. The vast majority of studies have shown a link between maternal consumption of cannabis and foetal development. Foetal growth restriction seems to be the major complication of cannabis exposure. Nevertheless, all these studies have suffered from several methodological biases. The maternal marijuana use should be first and foremost detected in pregnant women for a specific addiction management and pregnancy follow-up.

  6. Advanced cocaine-related necrotising sinusitis presenting with restrictive ophthalmolplegia.

    Lascaratos, Gerassimos; McHugh, James; McCarthy, Karon; Bunting, Howard


    We report a case of bilateral infero-medial orbital wall destruction, associated with loss of sinonasal architecture. The patient presented with intermittent horizontal diplopia following an acute on chronic infective sinusitis. Eight months previously the patient had developed a midline hard palate fistula for which a palatine prosthesis had been fitted. The broad differential diagnosis is discussed, though in this patient chronic cocaine abuse was identified as the underlying aetiology. Eye movement restriction worsened progressively with bilateral inflammation around the medial and inferior rectus muscles. Attempts to resolve the recurring cycle of sinus infection and inflammation by palatal fistula closure failed despite augmented techniques mobilising flaps from both nasal and palatal sides.

  7. Detecting Violations of Unidimensionality by Order-Restricted Inference Methods

    Moritz eHeene


    Full Text Available The assumption of unidimensionality and quantitative measurement represents one of the key concepts underlying most of the commonly applied of item response models. The assumption of unidimensionality is frequently tested although most commonly applied methods have been shown having low power against violations of unidimensionality whereas the assumption of quantitative measurement remains in most of the cases only an (implicit assumption. On the basis of a simulation study it is shown that order restricted inference methods within a Markov Chain Monte Carlo framework can successfully be used to test both assumptions.

  8. Visual expression of the experiences of restrictive eating

    Mark, Edith

    Background of the research: Visual methods are used in nursing research. These methods include media such as film, video, still images, material artifacts and drawing. The current study is a PhD project, dealing with children's experiences of eating restrictively (diabetes or obesity). Visual...... methods were used as a complement to qualitative research methods (e.g., interviews) in an effort to explore and identify children's perceptions of life situation. Purpose for the presentation: Presenting the use of visual methods as a research tool in the phenomenological nursing research...

  9. Optimal inference in dynamic models with conditional moment restrictions

    Christensen, Bent Jesper; Sørensen, Michael

    By an application of the theory of optimal estimating function, optimal in- struments for dynamic models with conditional moment restrictions are derived. The general efficiency bound is provided, along with estimators attaining the bound. It is demonstrated that the optimal estimators are always...... optimal estimator reduces to Newey's. Specification and hypothesis testing in our framework are introduced. We derive the theory of optimal instruments and the associated asymptotic dis- tribution theory for general cases including non-martingale estimating functions and general history dependence...

  10. Principal Bundles whose Restrictions to a Curve are Isomorphic

    Sudarshan Rajendra Gurjar


    Let be a normal projective variety defined over an algebraically closed field . Let $|O_X(1)|$ be a very ample invertible sheaf on . Let be an affine algebraic group defined over . Let $E_G$ and $F_G$ be two principal -bundles on . Then there exists an integer $n \\gg 0$ (depending on $E_G$ and $F_G$) such that if the restrictions of $E_G$ and $F_G$ to a curve $C\\in |O_X(n)|$ are isomorphic, then they are isomorphic on all of .

  11. DUNDRUM Restriction-Intrusion of Liberty Ladders (DRILL) Audit Toolkit

    Kennedy, Harry G


    This series of rating \\'ladders\\' is intended to allow a quantitative and qualitative analysis of the use of restrictive and intrusive interventions as part of the therapeutic management of violence and aggression in psychiatric hospital settings. This is an evolving handbook. The ladders are currently organised to facilitate a behavioural analysis. Context, antecedents, behaviour, interventions, consequences are conceptualised as a series of events organised in temporal sequence so that causes, interactions and effects can be considered. The complexity of analysis possible is limited by the statistical power of the numbers of cases and events available. \\r\

  12. Extreme calorie restriction and energy source starvation in Saccharomyces cerevisiae represent distinct physiological states

    Boender, L.G.M.; Almering, M.J.H.; Dijk, M.; Van Maris, A.J.A.; De Winde, J.H.; Pronk, J.T.; Daran-Lapujade, P.


    Cultivation methods used to investigate microbial calorie restriction often result in carbon and energy starvation. This study aims to dissect cellular responses to calorie restriction and starvation in Saccharomyces cerevisiae by using retentostat cultivation. In retentostats, cells are continuousl

  13. Trade restrictions as viable means of enforcing compliance with international environmental law: an economic assessment

    Kirchgaessner, G. [SIASR-HSG, St. Gallen (Switzerland); Mohr, E. [IWOe-HSG, St. Gallen (Switzerland)


    The contribution addresses some general problems of trade restrictions and the established international or national regimes of restrictions and sanctions, the role of environmental treaties and agreements, and issues of the debt-environmental treaty link-up.(CB)

  14. Genetics Home Reference: intrauterine growth restriction, metaphyseal dysplasia, adrenal hypoplasia congenita, and ...

    ... IMAGe syndrome intrauterine growth restriction, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies Enable Javascript to view ... combination of intrauterine growth restriction, metaphyseal dysplasia, adrenal hypoplasia congenita, and genital anomalies is commonly known by ...

  15. Improving prediction of binge episodes by modelling chronicity of dietary restriction.

    Holmes, Millicent; Fuller-Tyszkiewicz, Matthew; Skouteris, Helen; Broadbent, Jaclyn


    This study evaluates the influences of chronicity of, and time lag between, dietary restriction and binge outcome for predicting binge episode onset. Sixty-two women aged 18 to 40 years old completed an online survey at random intervals seven times daily for a 7-day period. Participants self-reported engagement in dietary restriction and/or binging, and temptation to binge. Consecutive instances of reported dietary restriction better predicted subsequent binges than single instances. As the time lag between the first report of dietary restriction and binge onset increased, a clear linear trend emerged, such that the value of restriction for predicting binges increased with the number of consecutive assessments in which they reported dietary restriction. A similar pattern was found when predicting temptation to binge. Present findings suggest that duration of restriction is a crucial determinant of binge onset. These findings have implications for clinical practice by highlighting the time course from dietary restriction to binging.

  16. Regression Analysis of Restricted Mean Survival Time Based on Pseudo-Observations

    Andersen, Per Kragh; Hansen, Mette Gerster; Klein, John P.


    censoring; hazard function; health economics; mean survival time; pseudo-observations; regression model; restricted mean survival time; survival analysis......censoring; hazard function; health economics; mean survival time; pseudo-observations; regression model; restricted mean survival time; survival analysis...

  17. Regression analysis of restricted mean survival time based on pseudo-observations

    Andersen, Per Kragh; Hansen, Mette Gerster; Klein, John P.

    censoring; hazard function; health economics; regression model; survival analysis; mean survival time; restricted mean survival time; pseudo-observations......censoring; hazard function; health economics; regression model; survival analysis; mean survival time; restricted mean survival time; pseudo-observations...

  18. Physical activity, energy restriction, and the risk of pancreatic cancer: Prospective study in the Netherlands

    Heinen, M.M.; Verhage, B.A.J.; Goldbohm, R.A.; Lumey, L.H.; Brandt, P.A. van den


    Background: Because of their influence on insulin concentrations, we hypothesized that both physical activity and energy restriction may reduce the risk of pancreatic cancer. Objective: We examined the associations between physical activity, proxies for energy restriction, and pancreatic cancer risk

  19. An Efficient Restrictive Blind Signature Scheme with Applications to Electronic Cash


    In this paper, a new restrictive blind signature scheme is proposed. Compared with Brands restrictive blind signature scheme, our scheme is even more restrictive and efficient. And our scheme is proved secure, too. A new withdrawal protocol of electronic cash system is designed by using our restrictive blind signature scheme, which is more efficient than the withdrawal protocol and is more appropriate for adopting pre-processing and post-processing.

  20. Restriction endonuclease mapping of linear unintegrated proviral DNA of bovine leukemia virus.

    Kettmann, R; Couez, D; Burny, A


    A detailed restriction map was deduced for the genome of the exogenous bovine leukemia virus. The cleavage sites for nine restriction enzymes were mapped. The unintegrated linear viral DNA intermediate that is produced by infection of permissive cells with bovine leukemia virus was isolated. The linear viral DNA had a unique restriction map, indicating that it is not a set of random circular permutations of the RNA genome. From hybridization with a 3'-enriched probe, the DNA restriction map w...

  1. Land Market Restrictions, Women's Labor Force Participation, and Wages in a Rural Economy

    Emran, M. Shahe; Shilpi, Forhad


    This paper analyzes the effects of land market restrictions on the rural labor market outcomes for women. The existing literature emphasizes two mechanisms through which land restrictions can affect the economic outcomes: the collateral value of land, and (in) security of property rights. Analysis of this paper focuses on an alternative mechanism where land restrictions increase costs of m...

  2. 33 CFR 162.215 - Lake Tahoe, Nev.; restricted area adjacent to Nevada Beach.


    ... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Lake Tahoe, Nev.; restricted area adjacent to Nevada Beach. 162.215 Section 162.215 Navigation and Navigable Waters COAST GUARD, DEPARTMENT... § 162.215 Lake Tahoe, Nev.; restricted area adjacent to Nevada Beach. (a) The restricted area....

  3. 5 CFR 332.407 - Restriction of consideration to one sex.


    ... 5 Administrative Personnel 1 2010-01-01 2010-01-01 false Restriction of consideration to one sex... Restriction of consideration to one sex. An appointing officer may not restrict his consideration of eligibles... competitive service to one sex, except in unusual circumstances when OPM finds the action justified....

  4. 78 FR 56832 - Extension of Import Restrictions Imposed on Archaeological Material From Cambodia From the Bronze...


    ... Extension of Import Restrictions Imposed on Archaeological Material From Cambodia From the Bronze Age... material from Cambodia from the Bronze Age through the Khmer era. The restrictions, which were originally... archaeological material from the Bronze Age through the Khmer Era. Import restrictions listed in 19 CFR...

  5. Examining Restricted and Repetitive Behaviors in Young Children with Autism Spectrum Disorder during Two Observational Contexts

    Stronach, Sheri; Wetherby, Amy M.


    This prospective study of the FIRST WORDS® Project examined restricted and repetitive behaviors in a sample of 55 toddlers at a mean age of 20 months who were later diagnosed with autism spectrum disorder. Restricted and repetitive behaviors were coded using the Repetitive Movement and Restricted Interest Scales in two video-recorded observation…

  6. Characterizing Caregiver Responses to Restricted and Repetitive Behaviors in Toddlers with Autism Spectrum Disorder

    Harrop, Clare; Gulsrud, Amanda; Shih, Wendy; Hovsepyan, Lilit; Kasari, Connie


    Restricted and repetitive behaviors are a core feature of autism spectrum disorder. This descriptive study documented the presence of restricted and repetitive behaviors in 85 toddlers with autism spectrum disorder as they interacted with their caregiver in a play interaction. For each child restricted and repetitive behavior, a caregiver…

  7. 10 CFR 95.35 - Access to matter classified as National Security Information and Restricted Data.


    ... SECURITY CLEARANCE AND SAFEGUARDING OF NATIONAL SECURITY INFORMATION AND RESTRICTED DATA Control of Information § 95.35 Access to matter classified as National Security Information and Restricted Data. (a... have access to matter revealing Secret or Confidential National Security Information or Restricted...

  8. 33 CFR 334.1220 - Hood Canal, Bangor; naval restricted areas.


    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Hood Canal, Bangor; naval restricted areas. 334.1220 Section 334.1220 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE DANGER ZONE AND RESTRICTED AREA REGULATIONS § 334.1220 Hood Canal, Bangor; naval restricted areas. (a) Hood...

  9. 48 CFR 27.404-2 - Limited rights data and restricted computer software.


    ... restricted computer software. 27.404-2 Section 27.404-2 Federal Acquisition Regulations System FEDERAL... Copyrights 27.404-2 Limited rights data and restricted computer software. (a) General. The basic clause at 52... restricted computer software by withholding the data from the Government and instead delivering form,...

  10. 22 CFR 51.64 - Special validation of passports for travel to restricted areas.


    ... restricted areas. 51.64 Section 51.64 Foreign Relations DEPARTMENT OF STATE NATIONALITY AND PASSPORTS PASSPORTS Denial, Revocation, and Restriction of Passports § 51.64 Special validation of passports for travel to restricted areas. (a) A U.S. national may apply to the Department for a special validation...

  11. Restricted Object Use in Young Children with Autism: Definition and Construct Validity

    Bruckner, Cornelia Taylor; Yoder, Paul


    There are currently no measures of restricted object use in young children with autism. In this study the object play of 27 young children with autism was measured in a semi-structured context to quantify restricted object use. It was hypothesized that children who engaged in less restricted object use would show better responding, joint…

  12. 29 CFR 790.20 - Right of employees to sue; restrictions on representative actions.


    ... 29 Labor 3 2010-07-01 2010-07-01 false Right of employees to sue; restrictions on representative... 1938 Restrictions and Limitations on Employee Suits § 790.20 Right of employees to sue; restrictions on..., no longer permits an employee or employees to designate an agent or representative (other than...

  13. 7 CFR 319.37-12 - Prohibited articles accompanying restricted articles.


    ... 7 Agriculture 5 2010-01-01 2010-01-01 false Prohibited articles accompanying restricted articles... Stock, Plants, Roots, Bulbs, Seeds, and Other Plant Products 1,2 § 319.37-12 Prohibited articles accompanying restricted articles. A restricted article for importation into the United States shall not...

  14. Sildenafil citrate and uteroplacental perfusion in fetal growth restriction

    Marzieh Vahid Dastjerdi


    Full Text Available Background: To determine whether the phosphodiesterase type 5 inhibitor, Sildenafil citrate, affects uteroplacental perfusion. Materials and Methods: Based on a randomized double-blinded and placebo-controlled trial, forty one pregnant women with documented intrauterine growth retardation at 24-37 weeks of gestation were evaluated for the effect of a single dose of Sildenafil citrate on uteroplacental circulation as determined by Doppler ultrasound study of the umbilical and middle cerebral arteries. Statistical analysis included χ2 -test to compare proportions, and independent-samples t-test and paired student′s t-test to compare continuous variables. Results: Sildenafil group fetuses demonstrated a significant decrease in systolic/diastolic ratios (0.60 [SD 0.40] [95% Cl 0.37-0.84], P=0.000, and pulsatility index (0.12 [SD 0.15] [95% Cl 0.02-0.22], P=0.019 for the umbilical artery and a significant increase in middle cerebral artery pulsatility index (MCA PI (0.51 [SD 0.60] [95% Cl 0.16-0.85], P=0.008. Conclusion: Doppler velocimetry index values reflect decreased placental bed vascular resistance after Sildenafil. Sildenafil citrate can improve fetoplacental perfusion in pregnancies complicated by intrauterine growth restriction. It could be a potential therapeutic strategy to improve uteroplacental blood flow in pregnancies with fetal growth restriction (FGR.

  15. Controlling the enzymatic activity of a restriction enzyme by light.

    Schierling, Benno; Noël, Ann-Josée; Wende, Wolfgang; Hien, Le Thi; Volkov, Eugeny; Kubareva, Elena; Oretskaya, Tatiana; Kokkinidis, Michael; Römpp, Andreas; Spengler, Bernhard; Pingoud, Alfred


    For many applications it would be desirable to be able to control the activity of proteins by using an external signal. In the present study, we have explored the possibility of modulating the activity of a restriction enzyme with light. By cross-linking two suitably located cysteine residues with a bifunctional azobenzene derivative, which can adopt a cis- or trans-configuration when illuminated by UV or blue light, respectively, enzymatic activity can be controlled in a reversible manner. To determine which residues when cross-linked show the largest "photoswitch effect," i.e., difference in activity when illuminated with UV vs. blue light, > 30 variants of a single-chain version of the restriction endonuclease PvuII were produced, modified with azobenzene, and tested for DNA cleavage activity. In general, introducing single cross-links in the enzyme leads to only small effects, whereas with multiple cross-links and additional mutations larger effects are observed. Some of the modified variants, which carry the cross-links close to the catalytic center, can be modulated in their DNA cleavage activity by a factor of up to 16 by illumination with UV (azobenzene in cis) and blue light (azobenzene in trans), respectively. The change in activity is achieved in seconds, is fully reversible, and, in the case analyzed, is due to a change in V(max) rather than K(m).


    David Kairupan


    Full Text Available Certain provisions of Presidential Regulation No. 36 of 2010 concerning Negative Investment List are not clearly stipulated. In relation to the restrictions of foreign investment in certain business sectors asspecified in the Negative Investment List Article 33 para. (1 and (2 of the 2007 Investment Law expressly prohibits investors from entering into any nominee shareholding documentation. Notwithstanding, manynominee shareholding practices are still employed in Indonesia, aiming to circumvent such restrictions.This paper addresses certain issues on Presidential Regulation No. 36 of 2010 and nominee shareholding practices in Indonesia. Beberapa ketentuan dalam peraturan Presiden No. 36 Tahun 2010 yang mengandung ketentuan Daftar Negatif Investasi tidak dirumuskan secara jelas. Sehubungan dengan pembatasan kepemilikan modal asing di beberapa sektor usaha, Pasal 33 ayat (1 dan (2 Undang-Undang Penanaman Modal No. 25 Tahun 2007 secara tegas melarang penanam modal membuat dokumen-dokumen yang terkait dengankepemilikan saham secara nominee. Namun demikian, praktik kepemilikan saham secara nominee masih sering dilakukan di Indonesia untuk menghindari pembatasan tersebut. Tulisan ini akan membahasbeberapa permasalahan yang berhubungan dengan Peraturan Presiden No. 36 Tahun 2010 dan praktek kepemilikan saham secara nominee di Indonesia.

  17. Low-resolution remeshing using the localized restricted voronoi diagram

    Yan, Dongming


    A big problem in triangular remeshing is to generate meshes when the triangle size approaches the feature size in the mesh. The main obstacle for Centroidal Voronoi Tessellation (CVT)-based remeshing is to compute a suitable Voronoi diagram. In this paper, we introduce the localized restricted Voronoi diagram (LRVD) on mesh surfaces. The LRVD is an extension of the restricted Voronoi diagram (RVD), but it addresses the problem that the RVD can contain Voronoi regions that consist of multiple disjoint surface patches. Our definition ensures that each Voronoi cell in the LRVD is a single connected region. We show that the LRVD is a useful extension to improve several existing mesh-processing techniques, most importantly surface remeshing with a low number of vertices. While the LRVD and RVD are identical in most simple configurations, the LRVD is essential when sampling a mesh with a small number of points and for sampling surface areas that are in close proximity to other surface areas, e.g., nearby sheets. To compute the LRVD, we combine local discrete clustering with a global exact computation. © 1995-2012 IEEE.

  18. Restricted calorie ketogenic diet for the treatment of glioblastoma multiforme.

    Maroon, Joseph; Bost, Jeffrey; Amos, Austin; Zuccoli, Giulio


    Glioblastoma multiforme is the most common malignant primary brain tumor in adults and generally considered to be universally fatal. Glioblastoma multiforme accounts for 12% to 15% of all intracranial neoplasms and affects 2 to 3 adults per every 100,000 in the United States annually. In children glioblastoma multiforme accounts for only approximately 7% to 9% of central nervous system tumors. The mean survival rate in adults after diagnosis ranges from 12 to 18 months with standard therapy and 3 to 6 months without therapy. The prognosis in children is better compared to adult tumor onset with a mean survival of approximately 4 years following gross total surgical resection and chemotherapy. There have been few advances in the treatment of glioblastoma multiforme in the past 40 years beyond surgery, radiotherapy, chemotherapy, and corticosteroids. For this reason a restrictive calorie ketogenic diet, similar to that used in children to control drug resistant seizure activity, has been advanced as an alternative adjunctive treatment to help prolonged survival. This article reviews the science of tumor metabolism and discusses the mechanism of calorie restriction, cellular energy metabolism, and how dietary induced ketosis can inhibit cancer cell's energy supply to slow tumor growth.

  19. Lifelong caloric restriction increases working memory in mice.

    Angela Kuhla

    Full Text Available Caloric restriction (CR is argued to positively affect general health, longevity and the normally occurring age-related reduction of cognition. This issue is well examined, but most studies investigated the effect of short-term periods of CR. Herein, 4 weeks old female mice were fed caloric restricted for 4, 20 and especially for 74 weeks. CR mice received 60% of food eaten by their ad libitum (AL fed littermates, and all age-matched groups were behaviorally analyzed. The motor coordination, which was tested by rotarod/accelerod, decreased age-related, but was not influenced by the different periods of CR. In contrast, the age-related impairment of spontaneous locomotor activity and anxiety, both being evaluated by open field and by elevated plus maze test, was found aggravated by a lifelong CR. Measurement of cognitive performance with morris water maze showed that the working memory decreased age-related in AL mice, while a lifelong CR caused a better cognitive performance and resulted in a significantly better spatial memory upon 74 weeks CR feeding. However, a late-onset CR feeding in 66 weeks old mice did not ameliorate the working memory. Therefore, a lifelong CR seems to be necessary to improve working memory.

  20. Lifelong caloric restriction increases working memory in mice.

    Kuhla, Angela; Lange, Sophie; Holzmann, Carsten; Maass, Fabian; Petersen, Jana; Vollmar, Brigitte; Wree, Andreas


    Caloric restriction (CR) is argued to positively affect general health, longevity and the normally occurring age-related reduction of cognition. This issue is well examined, but most studies investigated the effect of short-term periods of CR. Herein, 4 weeks old female mice were fed caloric restricted for 4, 20 and especially for 74 weeks. CR mice received 60% of food eaten by their ad libitum (AL) fed littermates, and all age-matched groups were behaviorally analyzed. The motor coordination, which was tested by rotarod/accelerod, decreased age-related, but was not influenced by the different periods of CR. In contrast, the age-related impairment of spontaneous locomotor activity and anxiety, both being evaluated by open field and by elevated plus maze test, was found aggravated by a lifelong CR. Measurement of cognitive performance with morris water maze showed that the working memory decreased age-related in AL mice, while a lifelong CR caused a better cognitive performance and resulted in a significantly better spatial memory upon 74 weeks CR feeding. However, a late-onset CR feeding in 66 weeks old mice did not ameliorate the working memory. Therefore, a lifelong CR seems to be necessary to improve working memory.

  1. Thrombocytopenia in Preterm Infants with Intrauterine Growth Restriction



    Full Text Available Sick preterm infants often have thrombocytopenia at birth, and this is often associated with intrauterine growth restriction (IUGR, or birth weights less than the 10th percentile. The pathogenesis of the thrombocytopenia and its importance in IUGR are still unclear. We studied the characteristics of preterm IUGR infants with thrombocytopenia. Twenty-seven singleton Japanese preterm IUGR infants were born between January 2002 and June 2007 at Okayama University Hospital. Infants with malformation, chromosomal abnormalities, alloimmune thrombocytopenia, sepsis, and maternal aspirin ingestion were excluded. The infants were divided into group A (n=8, which had thrombocytopenia within 72h after birth, and group B (n=19, which did not. There were significant differences in birth weight, head circumference, umbilical artery (UA-pulsatility index (PI, middle cerebral artery-PI, UA-pH, UA-pO2, and UA-pCO2. The infants in group A were smaller, had abnormal blood flow patterns, and were hypoxic at birth. We speculate that the infants with thrombocytopenia were more severely growth-restricted by chronic hypoxia. Thrombocytopenia is an important parameter for chronic hypoxia in the uterine.

  2. Restrictive metric regularity and generalized differential calculus in Banach spaces

    Bingwu Wang


    Full Text Available We consider nonlinear mappings f:X→Y between Banach spaces and study the notion of restrictive metric regularity of f around some point x¯, that is, metric regularity of f from X into the metric space E=f(X. Some sufficient as well as necessary and sufficient conditions for restrictive metric regularity are obtained, which particularly include an extension of the classical Lyusternik-Graves theorem in the case when f is strictly differentiable at x¯ but its strict derivative ∇f(x¯ is not surjective. We develop applications of the results obtained and some other techniques in variational analysis to generalized differential calculus involving normal cones to nonsmooth and nonconvex sets, coderivatives of set-valued mappings, as well as first-order and second-order subdifferentials of extended real-valued functions.

  3. 78 FR 24985 - Amendment of Restricted Areas R-6703A, B, C, D; and Establishment of Restricted Areas R-6703E, F...


    ... Federal Aviation Administration 14 CFR Part 73 RIN 2120-AA66 Amendment of Restricted Areas R-6703A, B, C, D; and Establishment of Restricted Areas R-6703E, F, G, H, I, and J; WA AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action modifies the internal boundaries of R-6703...

  4. May a Public University Restrict Faculty Expression on Its Internet World Wide Web Sites? Academic Freedom and University Facility Use Restrictions.

    Allred, Lisa R.


    Public university restriction of faculty expression on the institution's World Wide Web server is discussed based on recent Supreme Court decisions. It is proposed that in some circumstances, content-based restriction of faculty expression is permissible and will not violate the First Amendment academic freedom rights of faculty. (MSE)

  5. Smoking in hotels: prevalence, and opinions about restrictions.

    Semmonds, A; Bailey, K; Bentley, S; Chase, V; Fernando, S; Guruge, A; King, M; Tan, O M; Walsh, R


    Exposure to high levels of environmental tobacco smoke can occur in hotels. Controversy exists about smoking regulation on licensed premises. This survey of 138 people attending one of three Newcastle hotels during 1993 found that 57 per cent of respondents were nonsmokers. Fifty-eight per cent (95 per cent confidence interval (CI) 50 to 66 per cent) of respondents in these hotels believed their health was being adversely affected by other people's smoke in the hotel. Seventy per cent (CI 62 to 78 per cent), including half the smokers, were in favour of restriction of smoking in the hotels. Most preferred the establishment of smoke-free areas to the introduction of total smoking bans in hotels. The failure of hotels to regulate smoking suggests that a legislative approach is required. The case for legislation would be strengthened by a larger study elsewhere in Australia.

  6. Measurement of Restricted Atmospheric Barrier Discharge in Nonwoven Fiber Pores

    Kawabe, Masaaki

    The restricted dielectric barrier discharge in nonwoven pores has been investigated by observation of the current pulse, the Lissajous figure and light emissions. The current pulse measurement revealed that homogeneity of the discharge was relatively high and the amount of individual pulse was quite small on the order of 0.01nC. Such a small current pulse demonstrates that nonwoven fiber is effective as a dielectric barrier. Analysis of the Lissajous figure, indicates the calculated value of the gap voltage for the discharge starting point of nonwoven fiber layers is close to what was predicted using the Paschen curve. On the other hand, the measured value of the gap voltage in the Lissajous figure is larger than its calculated value, so the surface charge on the dielectrics dissipated relatively fast. The observations of light emissions also showed a high homogeneity.

  7. Emergence of Compositional Representations in Restricted Boltzmann Machines

    Tubiana, Jérôme


    Extracting automatically the complex set of features composing real high-dimensional data is crucial for achieving high performance in machine--learning tasks. Restricted Boltzmann Machines (RBM) are empirically known to be efficient for this purpose, and to be able to generate distributed and graded representations of the data. We characterize the structural conditions (sparsity of the weights, low effective temperature, nonlinearities in the activation functions of hidden units, and adaptation of fields maintaining the activity in the visible layer) allowing RBM to operate in such a compositional phase. Evidence is provided by the replica analysis of an adequate statistical ensemble of random RBMs and by RBM trained on the handwritten digits dataset MNIST.

  8. Matrices with restricted entries and q-analogues of permutations

    Lewis, Joel Brewster; Morales, Alejandro H; Panova, Greta; Sam, Steven V; Zhang, Yan


    We study the functions that count matrices of given rank over a finite field with specified positions equal to zero. We show that these matrices are $q$-analogues of permutations with certain restricted values. We obtain a simple closed formula for the number of invertible matrices with zero diagonal, a $q$-analogue of derangements, and a curious relationship between invertible skew-symmetric matrices and invertible symmetric matrices with zero diagonal. In addition, we provide recursions to enumerate matrices and symmetric matrices with zero diagonal by rank, and we frame some of our results in the context of Lie theory. Finally, we provide a brief exposition of polynomiality results for enumeration questions related to those mentioned, and give several open questions.

  9. Fetal growth restriction is associated with malaria in pregnancy

    Briand, Valérie; Saal, Jessica; Ghafari, Caline


    BACKGROUND: Few studies have evaluated the effect of malaria on intrauterine growth restriction on the basis of the fetal growth rate, rather than just the small-for-gestational age z score. Here, we assessed the impact of malaria on IUGR, using data from a longitudinal, ultrasonography......-based follow-up study of Beninese women. METHODS: A total of 1016 women were followed up from gestational week 17 to delivery. Malaria was detected every month. Women underwent ultrasonography 4 times for gestational age determination and fetal biometry. We assessed the effect of malaria on birth weight......-for-gestational age z score (n = 735 women) and fetal growth velocity (n = 664), defined as a change in fetal weight z score over time. RESULTS: Malaria was detected in 43% of women. Fetal growth velocity was negative overall, decreasing further at the end of the third trimester. Women with ≥2 malarial parasite...

  10. The road to deterministic matrices with the restricted isometry property

    Bandeira, Afonso S; Mixon, Dustin G; Wong, Percy


    The restricted isometry property (RIP) is a well-known matrix condition that provides state-of-the-art reconstruction guarantees for compressed sensing. While random matrices are known to satisfy this property with high probability, deterministic constructions have found less success. In this paper, we consider various techniques for demonstrating RIP deterministically, some popular and some novel, and we evaluate their performance. In evaluating some techniques, we apply random matrix theory and inadvertently find a simple alternative proof that certain random matrices are RIP. Later, we propose a particular class of matrices as candidates for being RIP, namely, equiangular tight frames (ETFs). Using the known correspondence between real ETFs and strongly regular graphs, we investigate certain combinatorial implications of a real ETF being RIP. Specifically, we give probabilistic intuition for a new bound on the clique number of Paley graphs of prime order, and we conjecture that the corresponding ETFs are R...

  11. An Additive-Multiplicative Restricted Mean Residual Life Model

    Mansourvar, Zahra; Martinussen, Torben; Scheike, Thomas H.


    mean residual life model to study the association between the restricted mean residual life function and potential regression covariates in the presence of right censoring. This model extends the proportional mean residual life model using an additive model as its covariate dependent baseline....... For the suggested model, some covariate effects are allowed to be time-varying. To estimate the model parameters, martingale estimating equations are developed, and the large sample properties of the resulting estimators are established. In addition, to assess the adequacy of the model, we investigate a goodness...... of fit test that is asymptotically justified. The proposed methodology is evaluated via simulation studies and further applied to a kidney cancer data set collected from a clinical trial....

  12. Approximate message passing with restricted Boltzmann machine priors

    Tramel, Eric W.; Drémeau, Angélique; Krzakala, Florent


    Approximate message passing (AMP) has been shown to be an excellent statistical approach to signal inference and compressed sensing problems. The AMP framework provides modularity in the choice of signal prior; here we propose a hierarchical form of the Gauss-Bernoulli prior which utilizes a restricted Boltzmann machine (RBM) trained on the signal support to push reconstruction performance beyond that of simple i.i.d. priors for signals whose support can be well represented by a trained binary RBM. We present and analyze two methods of RBM factorization and demonstrate how these affect signal reconstruction performance within our proposed algorithm. Finally, using the MNIST handwritten digit dataset, we show experimentally that using an RBM allows AMP to approach oracle-support performance.

  13. Polygons in restricted geometries subjected to infinite forces

    Beaton, N. R.; Eng, J. W.; Soteros, C. E.


    We consider self-avoiding polygons in a restricted geometry, namely an infinite L × M tube in {{{Z}}}3. These polygons are subjected to a force f, parallel to the infinite axis of the tube. When f\\gt 0 the force stretches the polygons, while when f\\lt 0 the force is compressive. We obtain and prove the asymptotic form of the free energy in both limits f\\to +/- ∞ . We conjecture that the f\\to -∞ asymptote is the same as the limiting free energy of ‘Hamiltonian’ polygons, polygons which visit every vertex in a L× M× N box. We investigate such polygons, and in particular use a transfer-matrix methodology to establish that the conjecture is true for some small tube sizes. Dedicated to Anthony J Guttmann on the occasion of his 70th birthday.

  14. Dietary carbohydrate restriction as the first approach in diabetes management

    Feinman, Richard D; Pogozelski, Wendy K; Astrup, Arne;


    , in combination with the continued success of low-carbohydrate diets in the treatment of diabetes and metabolic syndrome without significant side effects, point to the need for a reappraisal of dietary guidelines. The benefits of carbohydrate restriction in diabetes are immediate and well documented. Concerns...... side effects comparable with those seen in many drugs. Here we present 12 points of evidence supporting the use of low-carbohydrate diets as the first approach to treating type 2 diabetes and as the most effective adjunct to pharmacology in type 1. They represent the best-documented, least......The inability of current recommendations to control the epidemic of diabetes, the specific failure of the prevailing low-fat diets to improve obesity, cardiovascular risk, or general health and the persistent reports of some serious side effects of commonly prescribed diabetic medications...

  15. Perspective food addiction, caloric restriction, and dopaminergic neurotransmission

    Stankowska, Arwen Urrsula Malgorzata; Gjedde, Albert


    , and reduced activity in prefrontal regions of the cerebral cortex. The neurobiological characteristics suggest that obese people also have a pathological dependence in common with addicts, in the form of food addiction. Malnutrition and dieting both relate to binge eating, possibly as a compensation...... for a reduced cognitive reward condition. The combination of caloric restriction and food addiction imparts a high risk of relapse as a result of further reduction of dopaminergic neurotransmission and the subsequent loss of reward. As with drugs of abuse, ingestion of large quantities of sugar in circumstances...... of uncontrolled eating increases dopamine release in the nucleus accumbens. This and other evidence suggests that abuse of food is a habit learned by means of mechanisms centred in the basal ganglia, with an increased risk of relapse in the presence of associative amplifiers. This risk is predicted...

  16. A New Method of Improving Transformer Restricted Earth Fault Protection



    Full Text Available A new method of avoiding malfunctioning of the transformer restricted earth fault (REF protection is presented. Application of the proposed method would eliminate unnecessary operation of REF protection in the cases of faults outside protected zone of a transformer or a magnetizing inrush accompanied by current transformer (CT saturation. On the basis of laboratory measurements and simulations the paper presents a detailed performance assessment of the proposed method which is based on digital phase comparator. The obtained results show that the new method was stable and precise for all tested faults and that its application would allow making a clear and precise difference between an internal fault and: (i external fault or (ii magnetizing inrush. The proposed method would improve performance of REF protection and reduce probability of maloperation due to CT saturation. The new method is robust and characterized by high speed of operation and high reliability and security.

  17. Approximate Message Passing with Restricted Boltzmann Machine Priors

    Tramel, Eric W; Krzakala, Florent


    Approximate Message Passing (AMP) has been shown to be an excellent statistical approach to signal inference and compressed sensing problem. The AMP framework provides modularity in the choice of signal prior; here we propose a hierarchical form of the Gauss-Bernouilli prior which utilizes a Restricted Boltzmann Machine (RBM) trained on the signal support to push reconstruction performance beyond that of simple iid priors for signals whose support can be well represented by a trained binary RBM. We present and analyze two methods of RBM factorization and demonstrate how these affect signal reconstruction performance within our proposed algorithm. Finally, using the MNIST handwritten digit dataset, we show experimentally that using an RBM allows AMP to approach oracle-support performance.

  18. Sir2 and calorie restriction in yeast: a skeptical perspective.

    Kaeberlein, Matt; Powers, R Wilson


    Activation of Sir2-family proteins in response to calorie restriction (CR) has been proposed as an evolutionarily conserved mechanism for life span extension. This idea has been called into question with the discovery that Sir2-family proteins are not required for life span extension from CR in yeast. We present here a historical perspective and critical evaluation of the model that CR acts through Sir2 in yeast, and interpret prior reports in light of more recent discoveries. Several specific cases where the Sir2 model of CR is inconsistent with experimental data are noted. These shortcomings must be considered along with evidence supporting a role for Sir2 in CR in order to fully evaluate the validity of this model.

  19. Luminal progenitors restrict their lineage potential during mammary gland development.

    Veronica Rodilla


    Full Text Available The hierarchical relationships between stem cells and progenitors that guide mammary gland morphogenesis are still poorly defined. While multipotent basal stem cells have been found within the myoepithelial compartment, the in vivo lineage potential of luminal progenitors is unclear. Here we used the expression of the Notch1 receptor, previously implicated in mammary gland development and tumorigenesis, to elucidate the hierarchical organization of mammary stem/progenitor cells by lineage tracing. We found that Notch1 expression identifies multipotent stem cells in the embryonic mammary bud, which progressively restrict their lineage potential during mammary ductal morphogenesis to exclusively generate an ERαneg luminal lineage postnatally. Importantly, our results show that Notch1-labelled cells represent the alveolar progenitors that expand during pregnancy and survive multiple successive involutions. This study reveals that postnatal luminal epithelial cells derive from distinct self-sustained lineages that may represent the cells of origin of different breast cancer subtypes.

  20. Highly compressed nanosolution restricted in cylindrical carbon nanospaces

    Nishi, Masayasu; Ohkubo, Takahiro; Tsurusaki, Kazuma; Itadani, Atsushi; Ahmmad, Bashir; Urita, Koki; Moriguchi, Isamu; Kittaka, Shigeharu; Kuroda, Yasushige


    We shed light on the specific hydration structure around a zinc ion of nanosolution restricted in a cylindrical micropore of single-wall carbon nanotube (SWNT) by comparison with the structure restricted in a cylindrical mesopore of multi-wall carbon nanotube (MWNT) and that of bulk aqueous solution. The average micropore width of open-pore SWNT was 0.87 nm which is equivalent to the size of a hydrated zinc ion having 6-hydrated water molecules. We could impregnate the zinc ions into the micropore of SWNT with negligible amounts of ion-exchanged species on surface functional groups by the appropriate oxidation followed by heat treatment under an inert condition. The results of X-ray absorption fine structure (XAFS) spectra confirmed that the proportion of dissolved species in nanospaces against the total adsorbed amounts of zinc ions on the open-pore SWNT and MWNT were 44 and 61%, respectively, indicating the formation of a dehydrated structure in narrower nanospaces. The structure parameters obtained by the analysis of XAFS spectra also indicate that the dehydrated and highly compressed hydration structure can be stably formed inside the cylindrical micropore of SWNT where the structure is different from that inside the slit-shaped micropore whose pore width is less than 1 nm. Such a unique structure needs not only a narrow micropore geometry which is equivalent to the size of a hydrated ion but also the cylindrical nature of the pore.We shed light on the specific hydration structure around a zinc ion of nanosolution restricted in a cylindrical micropore of single-wall carbon nanotube (SWNT) by comparison with the structure restricted in a cylindrical mesopore of multi-wall carbon nanotube (MWNT) and that of bulk aqueous solution. The average micropore width of open-pore SWNT was 0.87 nm which is equivalent to the size of a hydrated zinc ion having 6-hydrated water molecules. We could impregnate the zinc ions into the micropore of SWNT with negligible amounts of

  1. Does Intellectual Property Restrict Output? An Analysis of Pharmaceutical Markets.

    Lakdawalla, Darius; Philipson, Tomas


    Standard normative analysis of intellectual property focuses on the balance between incentives for research and the static welfare costs of reduced price-competition from monopoly. However, static welfare loss from patents is not universal. While patents restrict price competition, they may also provide static welfare benefits by improving incentives for marketing, which is a form of non-price competition. We show theoretically how stronger marketing incentives mitigate, and can even offset, the static costs of monopoly pricing. Empirical analysis in the pharmaceutical industry context suggests that, in the short-run, patent expirations reduce consumer welfare as a result of decreased marketing effort. In the long-run, patent expirations do benefit consumers, but by 30% less than would be implied by the reduction in price alone. The social value of monopoly marketing to consumers alone is roughly on par with its costs to firms.

  2. Christmas cards workshop in a Restricted Access Ward

    Teresa García


    Full Text Available The Christmas cards workshop is an intervention study made in the Restricted Access Ward (RAW of Hospital Gregorio Marañón (Madrid, in December 2001, from the 5th to the 22nd. The object of this study was to assess the effectiveness of this workshop to improve the quality of the RAW patients´ hospital day, through their participation. They made 47 cards, the mean per patient was 1,52. Participation: 91,2% of the patients that fulfilled the inclusion criteria. Drawings and texts alluded to the convict´s perspective of Christmas time, from their own experience. The Christmas cards were exhibited in the hospital and they also were sent to different penitentiary institutions in Madrid, to make the RAW known. The course “Education for health for interdisciplinary projects in penitentiary institutions” was the frame of this workshop.

  3. Luminal progenitors restrict their lineage potential during mammary gland development.

    Rodilla, Veronica; Dasti, Alessandro; Huyghe, Mathilde; Lafkas, Daniel; Laurent, Cécile; Reyal, Fabien; Fre, Silvia


    The hierarchical relationships between stem cells and progenitors that guide mammary gland morphogenesis are still poorly defined. While multipotent basal stem cells have been found within the myoepithelial compartment, the in vivo lineage potential of luminal progenitors is unclear. Here we used the expression of the Notch1 receptor, previously implicated in mammary gland development and tumorigenesis, to elucidate the hierarchical organization of mammary stem/progenitor cells by lineage tracing. We found that Notch1 expression identifies multipotent stem cells in the embryonic mammary bud, which progressively restrict their lineage potential during mammary ductal morphogenesis to exclusively generate an ERαneg luminal lineage postnatally. Importantly, our results show that Notch1-labelled cells represent the alveolar progenitors that expand during pregnancy and survive multiple successive involutions. This study reveals that postnatal luminal epithelial cells derive from distinct self-sustained lineages that may represent the cells of origin of different breast cancer subtypes.

  4. A weight restricted DEA model for FMEA risk prioritization

    Pauli Adriano de Almada Garcia


    Full Text Available In this paper we present a linear programming (LP approach to risk prioritization in failure mode and effects analysis (FMEA. The LP is a data envelopment analysis (DEA-based model considering weight restriction. In a FMEA, we commonly consider three criteria to prioritize the failure modes, occurrence, severity and detectability. These criteria are in an ordinal scale commonly varying from 1 to 10, higher the figure worse the result. Considering the values established for each criteria, in traditional FMEA one adopts a Risk Priority Number, calculated considering the product of criteria, which has been very criticized due to its shortcoming. Through the proposed approach a frontier is established considering the less critical failure modes. Considering this frontier, one can establish how much each failure mode must be improved to become relatively acceptable. A simplified case concerning an AFWS of a two loops PWR power plant is presented to shows the applicability of the proposed approach.

  5. A weight restricted DEA model for FMEA risk prioritization

    Pauli Adriano de Almada Garcia


    Full Text Available In this paper we present a linear programming (LP approach to risk prioritization in failure mode and effects analysis (FMEA. The LP is a data envelopment analysis (DEA-based model considering weight restriction. In a FMEA, we commonly consider three criteria to prioritize the failure modes, occurrence, severity and detectability. These criteria are in an ordinal scale commonly varying from 1 to 10, higher the figure worse the result. Considering the values established for each criteria, in traditional FMEA one adopts a Risk Priority Number, calculated considering the product of criteria, which has been very criticized due to its shortcoming. Through the proposed approach a frontier is established considering the less critical failure modes. Considering this frontier, one can establish how much each failure mode must be improved to become relatively acceptable. A simplified case concerning an AFWS of a two loops PWR power plant is presented to shows the applicability of the proposed approach.

  6. Fate restriction and multipotency in retinal stem cells.

    Centanin, Lázaro; Hoeckendorf, Burkhard; Wittbrodt, Joachim


    Stem cells have the capacity to both self-renew and generate postmitotic cells. Long-term tracking of individual clones in their natural environment constitutes the ultimate way to validate postembryonic stem cells. We identify retinal stem cells (RSCs) using the spatiotemporal organization of the fish retina and follow the complete offspring of a single cell during the postnatal life. RSCs generate two tissues of the adult fish retina, the neural retina (NR) and the retinal-pigmented epithelium (RPE). Despite their common embryonic origin and tight coordination during continuous organ growth, we prove that NR and RPE are maintained by dedicated RSCs that contribute in a fate-restricted manner to either one or the other tissue. We show that in the NR, RSCs are multipotent and generate all neuron types and glia. The clonal origin of these different cell types from a multipotent NSC has far-reaching implications for cell type and tissue homeostasis.

  7. Cell entry of lymphocytic choriomeningitis virus is restricted in myotubes.

    Iwasaki, Masaharu; Urata, Shuzo; Cho, Yoshitake; Ngo, Nhi; de la Torre, Juan C


    In mice persistently infected since birth with the prototypic arenavirus lymphocytic choriomeningitis viurs, viral antigen and RNA are readily detected in most organs and cell types but remarkably absent in skeletal muscle. Here we report that mouse C2C12 myoblasts that are readily infected by LCMV, become highly refractory to LCMV infection upon their differentiation into myotubes. Myotube's resistance to LCMV was not due to an intracellular restriction of virus replication but rather an impaired cell entry mediated by the LCMV surface glycoprotein. Our findings provide an explanation for the observation that in LCMV carrier mice myotubes, which are constantly exposed to blood-containing virus, remain free of viral antigen and RNA despite myotubes express high levels of the LCMV receptor alpha dystroglycan and do not pose an intracellular blockade to LCMV multiplication.

  8. Classifying orbits in the restricted three-body problem

    Zotos, Euaggelos E


    The case of the planar circular restricted three-body problem is used as a test field in order to determine the character of the orbits of a small body which moves under the gravitational influence of the two heavy primary bodies. We conduct a thorough numerical analysis on the phase space mixing by classifying initial conditions of orbits and distinguishing between three types of motion: (i) bounded, (ii) escape and (iii) collisional. The presented outcomes reveal the high complexity of this dynamical system. Furthermore, our numerical analysis shows a remarkable presence of fractal basin boundaries along all the escape regimes. Interpreting the collisional motion as leaking in the phase space we related our results to both chaotic scattering and the theory of leaking Hamiltonian systems. We also determined the escape and collisional basins and computed the corresponding escape/collisional times. We hope our contribution to be useful for a further understanding of the escape and collisional mechanism of orbi...

  9. Fate-restricted neural progenitors in the mammalian cerebral cortex.

    Franco, Santos J; Gil-Sanz, Cristina; Martinez-Garay, Isabel; Espinosa, Ana; Harkins-Perry, Sarah R; Ramos, Cynthia; Müller, Ulrich


    During development of the mammalian cerebral cortex, radial glial cells (RGCs) generate layer-specific subtypes of excitatory neurons in a defined temporal sequence, in which lower-layer neurons are formed before upper-layer neurons. It has been proposed that neuronal subtype fate is determined by birthdate through progressive restriction of the neurogenic potential of a common RGC progenitor. Here, we demonstrate that the murine cerebral cortex contains RGC sublineages with distinct fate potentials. Using in vivo genetic fate mapping and in vitro clonal analysis, we identified an RGC lineage that is intrinsically specified to generate only upper-layer neurons, independently of niche and birthdate. Because upper cortical layers were expanded during primate evolution, amplification of this RGC pool may have facilitated human brain evolution.

  10. Restricted mouth opening and trismus in oral oncology.

    Satheeshkumar, P S; Mohan, Minu P; Jacob, Jayan


    Restricted mouth opening (RMO) and trismus are terms commonly used in oral oncology in instances where there is difficulty in mouth opening. The term trismus in oral oncology is mainly used to indicate the radiation-induced fibrosis of the muscles of mastication. The treatment given for RMO as reported in the literature is given for muscular dysfunction trismus, whereas RMO in oral oncology can occur owing to various reasons other than muscular dysfunction. RMO occurs in various conditions of the oral cavity; in posterior pharyngeal infection, where it is termed reflectory trismus; in oral submucous fibrosis; in oral mucosal disorders; in the use of certain drugs; and in minor dental procedures of the posterior oral cavity. The usage of the term trismus in all RMO cases would complicate the treatment; thus, the word should not be used in all RMO cases.

  11. Factors underlying restricted crossover localization in barley meiosis.

    Higgins, James D; Osman, Kim; Jones, Gareth H; Franklin, F Chris H


    Meiotic recombination results in the formation of cytological structures known as chiasmata at the sites of genetic crossovers (COs). The formation of at least one chiasma/CO between homologous chromosome pairs is essential for accurate chromosome segregation at the first meiotic division as well as for generating genetic variation. Although DNA double-strand breaks, which initiate recombination, are widely distributed along the chromosomes, this is not necessarily reflected in the chiasma distribution. In many species there is a tendency for chiasmata to be distributed in favored regions along the chromosomes, whereas in others, such as barley and some other grasses, chiasma localization is extremely pronounced. Localization of chiasma to the distal regions of barley chromosomes restricts the genetic variation available to breeders. Studies reviewed herein are beginning to provide an explanation for chiasma localization in barley. Moreover, they suggest a potential route to manipulating chiasma distribution that could be of value to plant breeders.

  12. Annual fasting; the early calories restriction for cancer prevention.

    Eslami, Solat; Barzgari, Zahra; Saliani, Negar; Saeedi, Nazli; Barzegari, Abolfazl


    Essentially, people's diet and nutritional status has been changed substantially worldwide and several lines of evidence suggest that these changes are to the detriment of their health. Additionally, it has been well documented that unhealthy diet especially the fast foods, untraditional foods or bad-eating-habits influence the human gut microbiome. The gut microbiota shapes immune responses during human life and affects his/her metabolomic profiles. Furthermore, many studies highlight the molecular pathways that mediate host and symbiont interactions that regulate proper immune function and prevention of cancer in the body. Intriguingly, if cancer forms in a human body due to the weakness of immune system in detriment of microbiome, the removal of cancer stem cells can be carried out through early Calories Restriction with Annual Fasting (AF) before tumor development or progress. Besides, fasting can balance the gut microbiome for enhancement of immune system against cancer formation.

  13. Complexity of Propositional Abduction for Restricted Sets of Boolean Functions

    Creignou, Nadia; Thomas, Michael


    Abduction is a fundamental and important form of non-monotonic reasoning. Given a knowledge base explaining how the world behaves it aims at finding an explanation for some observed manifestation. In this paper we focus on propositional abduction, where the knowledge base and the manifestation are represented by propositional formulae. The problem of deciding whether there exists an explanation has been shown to be SigmaP2-complete in general. We consider variants obtained by restricting the allowed connectives in the formulae to certain sets of Boolean functions. We give a complete classification of the complexity for all considerable sets of Boolean functions. In this way, we identify easier cases, namely NP-complete and polynomial cases; and we highlight sources of intractability. Further, we address the problem of counting the explanations and draw a complete picture for the counting complexity.

  14. Holographic Renyi Entropies and Restrictions on Higher Derivative Terms

    Pastras, Georgios


    We perform a holographic calculation of the Entanglement R\\'enyi entropy $S_q(\\mu,\\lambda)$, for spherical entangling surfaces in boundary CFT's with Einstein-Gauss-Bonnet-Maxwell holographic gravitational duals. We find that for Gauss-Bonnet couplings $\\lambda$, larger than a specific value, but still allowed by causality, a violation of an inequality that R\\'enyi entropies must obey by definition occurs. This violation is related to the existence of negative entropy black holes and restricts the coefficient of the Gauss-Bonnet coupling in the bulk theory. Furthermore, we discover a distinction in the analytic structure of the analytic continuation of $S_q(\\mu,\\lambda)$, between negative and non-negative $\\lambda$, suggesting the existence of a phase transition.

  15. Institutional violence towards Bolivian migrant woman. Marianism and mobility restriction

    Virginia Maria Fuentes Gutiérrez


    Full Text Available In this paper we outline some of the research results of a larger work which studies the Bolivian migration from a gender perspective, as well as the impact of the institutional practices that determine the transnational experience. In a global scene of restrictive rules concerning the human mobility, we notice how control and dominance strategies are present in ideologies and symbolic mechanisms. Women options in the migration process are trapped through them. We propose to recognize the symbolic and institutional violence that pressures migrants during their migration journey, focusing on understanding the ideological content — sexism and marianism — in which they are based on. We present an analysis of the instrumented ways of applying violence against Bolivian migrant women and its families from the social action practices implemented at origin and destination (transnational perspective.

  16. Dietary carbohydrate restriction as the first approach in diabetes management

    Feinman, Richard D; Pogozelski, Wendy K; Astrup, Arne;


    , in combination with the continued success of low-carbohydrate diets in the treatment of diabetes and metabolic syndrome without significant side effects, point to the need for a reappraisal of dietary guidelines. The benefits of carbohydrate restriction in diabetes are immediate and well documented. Concerns......The inability of current recommendations to control the epidemic of diabetes, the specific failure of the prevailing low-fat diets to improve obesity, cardiovascular risk, or general health and the persistent reports of some serious side effects of commonly prescribed diabetic medications...... side effects comparable with those seen in many drugs. Here we present 12 points of evidence supporting the use of low-carbohydrate diets as the first approach to treating type 2 diabetes and as the most effective adjunct to pharmacology in type 1. They represent the best-documented, least...

  17. Annual Fasting; the Early Calories Restriction for Cancer Prevention

    Solat Eslami


    Full Text Available Essentially, people’s diet and nutritional status has been changed substantially worldwide and several lines of evidence suggest that these changes are to the detriment of their health. Additionally, it has been well documented that unhealthy diet especially the fast foods, untraditional foods or bad-eating-habits influence the human gut microbiome. The gut microbiota shapes immune responses during human life and affects his/her metabolomic profiles. Furthermore, many studies highlight the molecular pathways that mediate host and symbiont interactions that regulate proper immune function and prevention of cancer in the body. Intriguingly, if cancer forms in a human body due to the weakness of immune system in detriment of microbiome, the removal of cancer stem cells can be carried out through early Calories Restriction with Annual Fasting (AF before tumor development or progress. Besides, fasting can b balance the gut microbiome for enhancement of immune system against cancer formation.

  18. Interpretation of topologically restricted measurements in lattice sigma-models

    Bautista, Irais; Gerber, Urs; Hofmann, Christoph P; Mejía-Díaz, Héctor; Prado, Lilian


    We consider models with topological sectors, and difficulties with their Monte Carlo simulation. In particular we are concerned with the situation where a simulation has an extremely long auto-correlation time with respect to the topological charge. Then reliable numerical measurements are possible only within single topological sectors. The challenge is to assemble such restricted measurements to obtain an approximation for the full-fledged result, which corresponds to the correct sampling over the entire set of configurations. Under certain conditions this is possible, and it provides in addition an estimate for the topological susceptibility chi_t. Moreover, the evaluation of chi_t might be feasible even from data in just one topological sector, based on the correlation of the topological charge density. Here we present numerical test results for these techniques in the framework of non-linear sigma-models.

  19. Caloric Restriction in Lean and Obese Strains of Laboratory ...

    NEW FINDINGS: What is the central question of this study? How do lean and obese rats respond physiologically to caloric restriction? What is the main finding and its importance? Obese rats show marked benefits compared with lean animals. Reduced body fat is associated with improved longevity with caloric restriction (CR) in rodents. Little is known regarding effects of CR in genetically lean versus obese strains. Long-Evans (LE) and Brown Norway (BN) rats make an ideal comparison for a CR study because the percentage body fat of young adult LE rats is double that of BN rats. Male LE and BN rats were either fed ad libitum (AL) or were caloricallyrestricted to 80 or 90% of their AL weight. The percentages of fat, lean and fluid mass were measured non-invasively at 2- to 4-week intervals. Metabolic rate and respiratory quotient were measured after 3, 6, 9 and 12 months of CR. Overall health was scored monthly. The percentage of fat of the LE strain decreased with CR, whereas the percentage of fat of the BN strain remained above the AL group for several months. The percentage of lean mass increased above the AL for both strains subjected to CR. The percentage offluid was unaffected by CR. The average metabolic rate over 22 h of the BN rats subjected to CR was reduced, whereas that of LE rats was increased slightly above the AL group. The respiratory quotient of BN rats wasdecreased with CR. Overall health of the CR LE group was significantly improved compared with t

  20. The method for environmental regulation of standardized specific emissions restricting

    Kurmankozhaev, Azimkhan; Jumanov, Beibit


    A correct geoethical environment protection demands to develop a highly efficient methodology and technology to the benefit of the population. Such a goal has been achieved by the described recommended method. It consists in substantiating standardized specific estimation criteria for regulating emissions of dust, sulfur oxide, nitrogen oxide, carbon oxide emitted when solid fuels are burnt in the conditions of heating plants. The complex of indicators reflects the degree of influence of thermal, technical, technological, ecological, economic and operational characteristics of fuels, boilers, etc. Nominal capacities are taking into account the performances of works and energy losses when fuel is burnt. For this purpose, a guiding concept of using specific criteria to evaluate pollutant emissions to the environment has been involved. A special model serves as an analytical basis for determining specific amount of emission for an ingredient into the atmosphere per unit of energy (heat) obtained from combustion of initial volume of fuel with appropriate energy losses. - The system of analytical estimations for determination of specific estimation criteria for regulation of solid particles, sulfur oxide, nitrogen oxide and carbon monoxide emissions released from combustion of solid fuels is derived by formulas for determination of their total emissions taking into consideration all technical and thermo-technical performance indicators of solid fuel and boiler units. - The acceptable reliability of the system of analytical estimations for regulating processes of air pollution restrictions has been achieved by modifying the existing models involving various performance characteristics of heating plants. - The method enables to determine specific standardized emission values for their constituent ingredients and specific individual criteria for a rational restriction of air pollution by particular environmental sources. The advantage of the method consists in increasing