WorldWideScience

Sample records for adenofibroma

  1. The Ultrasound and MRI Findings of Uterine Adenofibroma: A Case Report

    Energy Technology Data Exchange (ETDEWEB)

    Kim, Hyun Jung; Rha, Sung Eun; Byun, Jae Young; Lee, Ah Won [Seoul St. Mary' s Hospital, College of Medicine, The Catholic University of Korea, Seoul (Korea, Republic of)

    2011-09-15

    Adenofibroma is an extremely rare benign m'ullerian mixed tumor composed of epithelium and mesenchymal cells. Most uterine adenofibromas occur in the endometrium, but they rarely protrude into the vagina. To date, only a few such cases with the imaging findings have been reported. Therefore, we report here on the sonographic and magnetic resonance (MR) imaging findings of a case of endometrial adenofibroma protruding into the vaginal cavity in a 28-year-old woman. The uterine adenofibroma appeared as a large intracavitary echogenic mass containing multiple small internal cysts, and it was distending the vaginal cavity on transrectal sonography. T2- weighted MR images showed a large intracavitary mass with heterogeneous high signal intensity protruding into the vaginal cavity. On gadolinium-enhanced T1-weighted MR images, heterogeneous septa-like enhancement was noted in the mass. Although uterine adenofibroma is extremely rare, adenofibroma can be suggested as a possible diagnosis when an intracavitary uterine mass, with multiple internal small cystic components and enhancing septa-like structures, is protruding into the vaginal cavity on imaging

  2. Biliary Adenofibroma of the Liver: Report of a Case and Review of the Literature

    Directory of Open Access Journals (Sweden)

    Alessandra Gurrera

    2010-01-01

    Full Text Available We herein report the clinicopathologic features of a rare case of biliary adenofibroma (BAF of the liver in a 79-year-old man. Grossly, tumour presented as a well-circumscribed, 5.5-cm mass with a solid and microcystic appearance. Histological examination was typical of biliary adenofibroma, showing a proliferation of variable-sized tubulocystic structures embedded in a moderately cellular fibrous stroma. Immunohistochemistry, revealing immunoreactivity of the epithelial component to cytokeratins 7 and 19, was consistent with a bile duct origin. Notably, the stromal cells had a myofibroblastic profile, showing a diffuse and strong expression of vimentin and -smooth muscle actin. Differential diagnosis with Von Meyenburg complex, biliary adenoma, biliary cistadenoma, congenital biliary cystsy, and hepatic benign cystic mesothelioma is provided. The occasionally reported expression of p53 in biliary adenofibroma has suggested that this tumour could represent a premalignant lesion. The absence of both cytological atypia and p53 immunoreactivity in our case confirms that BAF is a benign tumour with an indolent clinical behaviour. However, a careful histological examination of BAF is mandatory because malignant transformation of the epithelial component has been documented in two cases.

  3. 复发性子宫苗勒源腺纤维瘤临床病理分析%Clinicopathological analysis of recurrent uterine Mullerian adenofibroma

    Institute of Scientific and Technical Information of China (English)

    潘在轩

    2015-01-01

    Objective To analyze and summarize the clinicopathological features of recurrent uterine Mullein adenofibroma . Methods 8 cases of recurrent uterine Mullein adenofibroma in our hospital from February 2003 to February 2014 were selected and analyzed on the clinical data for summarizing its clinicopathological features .Results In 8 cases of recurrent uterine M ullerian ade‐nofibroma ,the lobulated neoplasm could be found on outside of the cervix or inside of the uterus ,which was formed by the benign epithelial and mesenchymal tissue .Immunohistochemistry showed that the estrogen receptor (ER) was expressed in 8 cases ,some cases expressed progesterone receptor(PR) ,smooth muscle actin(SMA) ,CD10 and p53 ,and the mean average value of Ki‐67 (+ ) was 8% .Conclusion Recurrent uterine Mullerian adenofibroma has no specific clinicopathological changes ,its differential diagnosis with sarcoma is difficult .Only CD10 and Ki‐67 may be conducive to diagnosis .%目的:探讨复发性子宫苗勒源腺纤维瘤临床病理特征。方法选取2003年2月至2014年2月该院收治的复发性子宫苗勒源腺纤维瘤患者8例,分析其临床数据,总结子宫苗勒源腺纤维瘤的病理特点。结果8例复发性子宫苗勒源腺纤维瘤患者可在宫颈外或者宫腔内见分叶状赘生物,由良性上皮和间叶组织形成。免疫组化显示,8例患者均表达雌激素受体(ER),部分患者表达孕激素受体(PR)、平滑肌肌动蛋白(SMA)、CD10和p53,而Ki‐67(+)均值平均为8%。结论复发性子宫苗勒源腺纤维瘤临床病理无特异性变化,与腺肉瘤鉴别诊断困难,仅CD10和Ki‐67可能有助于诊断。

  4. Relationship Study between Multiple Adenofibroma and Personality of Young Women%青年女性好发的乳腺纤维瘤与性格的关系研究

    Institute of Scientific and Technical Information of China (English)

    谢庆; 马嘉莺; 顾小娟; 章程程; 李翼宏; 马雪茹

    2016-01-01

    Objective to explore relationship between multiple adenofibroma and personality of young women, and understand personality characteristics of adenofibroma patients, and put forward feasible suggestions of patient's personality.Methods carry on questionnaire survey on personality of adenofibroma patients with YG personality scale revised by psychology department of Huadong Normal University.Resultss investigation and analysis showed, 77.5% patients considered occurrence of adenofibroma was related with personality. Among personality types of adenofibroma patients, type A (stable, adaptive, balanced) accounted for 2.5%, type B (unstable, unadaptive, extraverted) accounted for 30%, type C (stable, adaptive, introverted) accounted for 20%, type D (stable, adaptive, extraverted) accounted for 17.5%, type E (unstable, unadaptive, introverted) accounted for 20%.Conclusion personality of adenofibroma patients mostly manifested as emotional instability, impatience, sensitivity, narrow-mind and introvert.%目的:探讨青年女性好发的乳腺纤维瘤与性格的关系,了解乳腺纤维瘤患者性格特点,并为患者在性格上提出可行性的建议。方法利用华东师范大学心理系修订的YG性格量表对乳腺纤维瘤患者的性格进行问卷调查。结果通过调查分析,77.5%患者认为乳腺纤维瘤的发生与性格有关。乳腺纤维瘤患者性格类型中A型(稳定适应平衡型)占2.5%,B型(不稳定不适应外向型)占30%,C型(稳定适应内向型)占20%,D型(稳定适应外向型)占17.5%,E型(不稳定不适应内向型)占20%。结论乳腺纤维瘤患者性格大多表现为情绪不稳定,易急躁,多愁善感,心胸狭窄,内向。

  5. KRAS/BRAF Analysis in Ovarian Low-Grade Serous Carcinoma Having Synchronous All Pathological Precursor Regions

    Directory of Open Access Journals (Sweden)

    Kohei Nakamura

    2016-04-01

    Full Text Available Ovarian low-grade serous carcinoma is thought to begin as a serous cystadenoma or adenofibroma that progresses in a slow stepwise fashion. Among the low-grade serous carcinomas, there is a high frequency of activating mutations in the KRAS or BRAF genes; however, it remains unclear as to how these mutations contribute to tumor progression. This is the first report to track the histopathological progression of serous adenofibroma to low-grade serous carcinoma. Each stage was individually analyzed by pathological and molecular genetic methods to determine what differences occur between the distinct stages of progression.

  6. 双侧卵巢浆液性腺纤维瘤合并多囊卵巢综合征1例

    Institute of Scientific and Technical Information of China (English)

    孙沛琳; 薛敏

    2010-01-01

    @@ 卵巢腺纤维瘤(ovary adenofibroma,OAF)为卵巢少见的实体良性肿瘤,双侧发生更为罕见.本例患者同时合并多囊卵巢综合征(polycystic ovary syndrome, PCOS),现报告如下.

  7. Value of high-frequency ultrasonography with virtual touch tissue quantification in diagnosis of breast pure mucinous carcinomas

    Institute of Scientific and Technical Information of China (English)

    Jian Shi; Guang Yang; Jialing Wu; Wenlin Xu

    2012-01-01

    Objective: The aim of our study was to analyze the characters of breast pure mucinous carcinomas on highfrequency ultrasonography with virtual touch tissue quantification (VTQ). Methods: A total of 12 patients (with breast pure mucinous carcinomas) and a group of 30 patients (with adenofibroma of breast) underwent breast examination with high-frequency ultrasonography to analyze the characters of images, and with VTQ to analyze the elastic character. Results: In the conventional ultrasound imaging, statistical differences were found between two groups in the shape, the boundary and the internal echo of the lesions. In the VTQ, the mean of shearing wave speed (Vs) in pure mucinous carcinomas was less than in adenofibroma of breast. Conclusion: Conventional high-frequency ultrasonography combining with VTQ have significant value in diagnosis of breast pure mucinous carcinoma.

  8. Carcinogenicity of the antineoplastic agent, 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide, and its metabolites in rats.

    Science.gov (United States)

    Beal, D D; Skibba, J L; Croft, W A; Cohen, S M; Bryan, G T

    1975-04-01

    Chronic oral administration of the antineoplastic agent, 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (NSC-45388, DTIC), induced predominantly thymic and mammary tumors as demonstrated previously. Male and female Sprague-Dawley and female Buffalo rats were susceptible to the carcinogenicity of DTIC. A 50% incidence of mammary adenocarcinomas was induced in males within 18 weeks. Type of tumor and tumor incidence were dose dependent. Single and multiple intraperitoneal injections of DTIC did not alter organ specificity. DTIC-induced thymic lymphosarcomas and mammary adenocarcinomas were transplantable. Tissue distribution studies revealed no correlation between uptake of DTIC by a given tissue and its susceptibility to carcinogenicity. Metabolites of DTIC were tested for carcinogenic activity. Animals administered 5-diazoimidazole-4-carboxamide orally, intraperitoneally, or intragastrically developed low incidences of thymic, stomach, bladder, or mammary tumors. A low incidence of mammary tumors developed in rats fed 2-azahypoxanthine. A variety of tumors, including several ependymoblastomas, were induced in rats that received 5-aminoimidazole-4-carboxamide orally. 5-(3-Methyl-1-triazeno)imidazole-4-carboxamide (MTIC), when fed or given in single or multiple intraperitoneal injections, induced a high incidence of mammary adenofibromas and a low incidence of uterine leiomyosarcomas. Control rats had low incidences of mammary adenocarcinomas and adenofibromas after 52 weeks. These data show that the carcinogenic properties of DTIC resemble those of carcinogenic N-nitroso compounds, hydrazine, azo, and azoxy-alkanes and aryltriazenes and thus suggest similar mechanism(s) of action. These data also indicate that MTIC is involved in the induction of mammary adenofibromas and uterine leiomyosarcomas by DTIC.

  9. Modification of radiation carcinogenesis by marihuana

    Energy Technology Data Exchange (ETDEWEB)

    Montour, J.L.; Dutz, W.; Harris, L.S.

    1981-03-15

    Male, female, and ovariectomized female Sprague-Dawley rats were irradiated with 400 rads, 150 rads, or 300 rads, respectively, of /sup 60/Co gamma rays when they were between 40 and 50 days of age. The animals were injected three times weekly with either marihuana extract or with alcohol-emulphor carrier. Comparable unirradiated groups were similarly injected. Mean survival time in males was significantly shorter in the 400 rad + marihuana group compared with the three other groups whose mean survival times did not differ. Through the 546 days that the males were observed, the total number of tumors other than fibrosarcomas was significantly greater following radiation and marihuana (22) than radiation alone (6). Fifteen of the tumors were of breast or endocrine tissues. No differences were seen in the unirradiated groups. In the females, which were observed for 635 days, the total number of breast tumors was greater with the combined treatment (38) compared with radiation alone (22). This was entirely due to a marked difference in the adenocarcinoma incidence, which was 21 (radiation + marihuana) compared with four (radiation alone). The number of adenofibromas was similar in the two groups. In the unirradiated female groups the breast adenocarcinoma incidence was eight in the marihuana group and two in the control group. Ovariectomy resulted in a lower breast tumor incidence in all groups. Nonbreast tumors were more frequent in the ovariectomized-irradiated groups. Radiation plus marihuana produced more nonbreast tumors (25) than radiation alone (17) in the ovariectomized females.

  10. Modification of radiation carcinogenesis by marijuana

    Energy Technology Data Exchange (ETDEWEB)

    Montour, J.L.; Dutz, W.; Harris, L.S.

    1981-03-15

    Male, female, and ovariectomized female Sprague-Dawley rats were irradiated with 400 rads, 150 rads, or 300 rads, respectively, of /sup 60/Co gamma rays when they were between 40 and 50 days of age. The animals were injected three times weekly with either marihuana extract or with alcohol-emulphor carrier. Comparable unirradiated groups were similarly injected. Mean survival time in males was significantly shorter in the 400 rad + marihuana group compared with the three other groups whose mean survival times did not differ. Through the 546 days that the males were observed, the total number of tumors other than fibrosarcomas was significantly greater following radiation and marihuana (22) than radiation alone (6). Fifteen of the tumors were of breast or endocrine tissues. No differences were seen in the unirradiated groups. In the females, which were observed for 635 days, the total number of breast tumors was greater with the combined treatment (38) compared with radiation alone (22). This was entirely due to a marked difference in the adenocarcinoma incidence, which was 21 (radiation + marihuana) compared with four (radiation alone). The number of adenofibromas was similar in the two groups. In the unirradiated female groups the breast adenocarcinoma incidence was eight in the marihuana group and two in the control group. Ovariectomy resulted in a lower breast tumor incidence in all groups. Nonbreast tumors were more frequent in the ovariectomized-irradiated groups. Radiation plus marihuana produced more nonbreast tumors (25) than radiation alone (17) in the ovariectomized females.

  11. Effects of long-term construction noise on health of adult female Wistar rats.

    Science.gov (United States)

    Zymantiene, J; Zelvyte, R; Pampariene, I; Aniuliene, A; Juodziukyniene, N; Kantautaite, J; Oberauskas, V

    2017-03-28

    The aim of this study was to investigate the influence of long-term building construction noise from refurbishment, which including vibration, on some physiological parameters and histopathological changes of organs of Wistar rats. Twenty 12 month old female rats were divided into two groups: rats group I (n = 10) were exposed to long-term construction noise and rats group II (n = 10) were kept under normal noise level. Study results revealed that long-term construction noise from building refurbishment has an influence on body weight, haematological and some serum biochemical parameters affects caecal microbiota, and causes histopathological changes in the organs of adult female Wistar rats. It was noticed that rats in group I exihibited significantly higher mean values for total protein, albumin and lower values for glucose, AST, ALT, blood urea nitrogen, haematological and caecal microbiota parameters than rats in group II. The most common pathologies were determined in the kidney, liver and lungs. Other observed pathologies were lymphadenopathy, catarrhal inflammation of the intestines, spleen hyperplasia and mammary gland adenofibroma. Single cases were subcutaneous fibroma in the thoracic region, abortus with uterine inflammation and thymus hyperplasia with formation of cysts were found.

  12. Studies on SSTR2 mRNA expression and its correlation to steroid receptors in human benign and malignant breast lesions

    Institute of Scientific and Technical Information of China (English)

    ZENG Xizhi(曾希志); YAO Zhenxiang(姚榛祥)

    2002-01-01

    Objective:This sudy was designed to observe somatostatin receptor subtype 2 (SSTR2) Mrna expression, and investigate the correlations between SSTR2 Mrna expression and steroid receptors in benign and malignant lesions of the breast. Methods: A total of 23 breast carcinomas,16 mammary hyperplasia and 9 mammary adenofibroma samples were analysed. The SSTR2 Mrna expression was examined by in situ hybridization using multiphase oligoprobes.The ER and PR were detected by immunohistochemical staining. A computerized image analysis system was utilized to estimate the relative contents of SSTR2 Mrna. Results: The positive rates of expression (87.0%) and relative contents (0.47) of SSTR2 Mrna in breast cancer were higher than those in benign breast lesions(64%,0.26) respectively( P<0.05). SSTR2 Mrna expression was closely correlated with ER and PR in breast cancer( P<0. 05), A positive correlation between SSTR2 Mrna expression and ER was also found in benign breast lesions. Conclusions: SSTR2 Mrna expressed both in benign and in malignant breast lesions, but higher in malignant than in benign ones. There was a significant positive correlation of SSTR2 Mrna expression with ER or PR. The results suggest that conbined treatment with an antiestrogen and a somatostatin analogue for ER-positive breast cancer is feasible.

  13. SIGNIFICANCE OF CLINICAL AND HISTOPATHOLOGICAL EVALUATION IN WOM EN WITH POSTMENOPAUSAL BLEEDING: A HOSPITAL BASED STUDY IN KASHMIR

    Directory of Open Access Journals (Sweden)

    Rizwana Habib

    2015-05-01

    Full Text Available BACKGROUND: Postmenopausal bleeding is a dreaded symptom both for the women and gynaecologist. Though it can be of benign origin, malignancy has to be ruled out and as such needs prompt evaluation. OBJECTIVE: (1 To study the etiological factors of postmenopausal bleeding and establish various endometrial causes of postmenopausal bleeding through histopathological evaluation. (2 To investigate the clinical significance of postmenopausal bleeding in terms of risk factors, incidence of malignancy and histopathological evaluation. METHODOLOGY: This observational study was conducted at Lalla Ded Hospital Srinagar over a period of 18 months in which 116 cases of postmenopausal bleeding were enrolled in the study. All patients were subjected to detailed history, examination and investigations follo wed by diagnostic curettage. Endometrial curretings were sent for histopathological examination. STATISTICAL ANALYSIS: Statistical Package for Social Sciences (SPSS V.16.0 and Microsoft Excel were used to carry statistical analysis of data. Data was analy zed with the help of descriptive statistics viz. %age, mean S.D. Graphically data was presented by bar and pie diagrams. RESULTS: Majority of the patients with postmenopausal bleeding were in the age of 45 - 55 years (63.8%, majority of cases 64(55.2% were para 1 - 3, uterus was of normal size in 53 cases (45.7% . Mean age of onset of menopause was 48.7 years. Obesity was found in 40 cases (34.5%, hypertension in 35 cases (30.2% , and diabetes in 12 cases (10.3% . Out of the 116 cases studied; the most commo n cause of bleeding in the postmenopausal age group was endometrial hyperplasia in 41 out of 116(35.3% followed by atrophic endometrium in 39 of 116(33.6% . Endometrial polyps were found in 9 (7.8% cases, proliferat ive endometrium was found in 10 (8.6% , endometritis was seen in 3(2.6% cases, secretory endometrium in 1(0.9% cases and adenofibroma in 1(0.9% cases. The incidence of endometrial carcinoma

  14. Mice deleted for cell division cycle 73 gene develop parathyroid and uterine tumours: model for the hyperparathyroidism-jaw tumour syndrome.

    Science.gov (United States)

    Walls, G V; Stevenson, M; Lines, K E; Newey, P J; Reed, A A C; Bowl, M R; Jeyabalan, J; Harding, B; Bradley, K J; Manek, S; Chen, J; Wang, P; Williams, B O; Teh, B T; Thakker, R V

    2017-03-13

    The hyperparathyroidism-jaw tumour (HPT-JT) syndrome is an autosomal dominant disorder characterized by occurrence of parathyroid tumours, often atypical adenomas and carcinomas, ossifying jaw fibromas, renal tumours and uterine benign and malignant neoplasms. HPT-JT is caused by mutations of the cell division cycle 73 (CDC73) gene, located on chromosome 1q31.2 and encodes a 531 amino acid protein, parafibromin. To facilitate in vivo studies of Cdc73 in tumourigenesis we generated conventional (Cdc73(+/-)) and conditional parathyroid-specific (Cdc73(+/L)/PTH-Cre and Cdc73(L/L)/PTH-Cre) mouse models. Mice were aged to 18-21 months and studied for survival, tumour development and proliferation, and serum biochemistry, and compared to age-matched wild-type (Cdc73(+/+) and Cdc73(+/+)/PTH-Cre) littermates. Survival of Cdc73(+/-) mice, when compared to Cdc73(+/+) mice was reduced (Cdc73(+/-)=80%; Cdc73(+/+)=90% at 18 months of age, Pfourfold higher than that in parathyroid glands of wild-type littermates (P<0.0001). Cdc73(+/-), Cdc73(+/L)/PTH-Cre and Cdc73(L/L)/PTH-Cre mice had higher mean serum calcium concentrations than wild-type littermates, and Cdc73(+/-) mice also had increased mean serum parathyroid hormone (PTH) concentrations. Parathyroid tumour development, and elevations in serum calcium and PTH, were similar in males and females. Cdc73(+/-) mice did not develop bone or renal tumours but female Cdc73(+/-) mice, at 18 months of age, had uterine neoplasms comprising squamous metaplasia, adenofibroma and adenomyoma. Uterine neoplasms, myometria and jaw bones of Cdc73(+/-) mice had increased proliferation rates that were 2-fold higher than in Cdc73(+/+) mice (P<0.05). Thus, our studies, which have established mouse models for parathyroid tumours and uterine neoplasms that develop in the HPT-JT syndrome, provide in vivo models for future studies of these tumours.Oncogene advance online publication, 13 March 2017; doi:10.1038/onc.2017.43.

  15. MR灌注参数(Ktrans)和扩散参数(ADC)在不同病理类型乳腺结节灶相关性的初步研究%A preliminary study on the correlation of MR perfusion parameters (ktrans) and diffusion parameters (ADC) in differ-ent pathological types of breast nodules

    Institute of Scientific and Technical Information of China (English)

    孙新儒; 罗昕; 何兵; 董军

    2016-01-01

    Objective To study the relevance of volume transfer constant ( Ktrans) values and apparent diffusion coefficient ( ADC) values can facilitate deeply understanding the correlation between breast cancer cells and its microenvironment .This pa-per will evaluate the relevance of Ktrans and ADC including different pathological types of breast nodules .Methods A retrospec-tive study was conducted with 52 patients with breast nodules , including 24 patients with breast cancer (average age 47.3 years old), and 28 patients with benign breast tumors (average age 42.1 years old).All patients underwent dynamic contrast-enhanced T1-weighted MR perfusion and diffusion-weighted imaging using a 1.5 T scanner .Ktrans was estimated by specially designed soft-ware.For each tumor, regions of interest (ROIs) were manually selected on corresponding Ktrans and ADC maps .Pearson corre-lation coefficients were obtained for maximum , mean and minimum values of Ktrans and ADC of all ROIs .Results The results of statistical analysis show the negative relevance when compare the max , min, and mean Ktrans and ADC values .The three pearson correlation coefficient (rmax, rmin and rmean) are respectively -0.483( P <0.001),-0.55( P <0.001), and -0.527( P <0.001).However, there is no significant correlation between Ktrans and ADC values in sub-pathological groups including adenofi-broma, papilloma and other benign breast tumors .Conclusion The results of this paper show that there is a negative correlation between quantitive parameters ( Ktrans and ADC ) of MR perfusion imaging and diffusion imaging in spite of the pathological types of breast nodules , which reveal that the number of tumor cells , ischemic injury , and complex changes of extracellular matrix may be modulated or influenced by the microvascular permeability .%目的:评估MR定量灌注参数( Ktrans)和扩散参数( ADC)在不同病理类型乳腺结节灶的相关性。方法对52例乳腺结节灶患者行动态对比

  16. Value of MRI in diagnosis of the cases with positive results of clinical palpation and non- symmetrical dense shadow displayed by mammography%MRI在临床触诊阳性的乳腺X线非对称性致密影病变诊断中的价值

    Institute of Scientific and Technical Information of China (English)

    赵弘; 曹满瑞; 杜牧; 张方景; 刘炳光; 朱志军

    2012-01-01

    Objective: To explore ihe value of MRI in diagnosis of benign and malignant breast diseases among the cases with positive results of clinical palpation and non - symmetrical dense shadow displayed by mammography. Methods: Eighty cases with positive results of clinical palpation and non - symmetrical dense shadow displayed by mammography were collected from the hospital from March 2009 to March 2012, without mass, calcification and structural distortion, the results were compared with pathological diagnosis after surgery, the shape, distribution, dynamic contrast, time curve, and surrounding imaging changes of the lesions were observed, the accurate rate of diagnosis was analyzed statistically. All the patients underwent mammography and MRI at two weeks before surgery. Results: Twenty - two cases were found with mass - type enhancement. and fifty - eight cases were found with non - mass - type enhancement; 14 cases were found with symmetrical enhancement, and 66 cases were found with asymmetrical enhancement; 34 cases were found with multiple abscess and symmetrical or asymmetrical circular enhancement of mass wall; 28 cases were found with abnormal dilated vessels with rich blood supply of diseased side compared with contralateral side, 32 cases were found with focal and extensive thickening of skin, 27 cases were found with subcutaneous edema; 15 cases were found with solid enlargement of alar lymph nides; 36 cases were found with type I time curve, 22 cases were found with type 11 time curve, and 22 cases were found with type 10 time curve. Forty - eight cases were found with benign breast lesions, including 8 cases with cyclomastopathy, 2 cases with sclerosing adenosis, 37 cases with breast inflammation (23 cases with chronic inflammation , 8 cases with granulomatous mastitis, 2 cases with plasma cell mastitis, and 4 cases with breast cysts combined with infection), and one case with breast adenofibroma; 32 cases were found with breast cancer, including 23 cases

  17. Slit2在乳腺组织的表达与乳腺癌脑转移的关系%Slit2 Expression in breast cancer and its relationship to brain metastasis

    Institute of Scientific and Technical Information of China (English)

    王乐; 马勇杰; 孙增峰; 刘芳芳; 付丽; 李文良; 谷峰

    2010-01-01

    Objective To detect the expression of Slit2 in breast tumors and its association with the breast cancer brain metastasis. Methods Immunohistochemistry staining was performed for Slit2 expression on specimens from 24 cases of invasive ductal carcinoma (IDC) with brain metastasis, 71 cases of IDC without brain metastasis, 22 cases of ductal carcinoma in situ (DCIS) and 23 cases of fibroadenoma.Results ( 1 ) The expression level of Slit2 in IDC with brain metastasis ( 13% ) was significantly lower than that in IDC without brain metastasis ( 59% ), P < 0. 05. (2) The expression level of Slit2 in IDC (48%) and DCIS (59%) was significantly lower than that in adenofibroma (87%),P <0.05. The expression of Slit2 in IDC was lower than that in DCIS, but had no significant difference,P > 0.05. (3) The expression of Slit2 was significantly higher in more than 50 year-old-group (62%) than that in less than 50 year-old-group (34%) of IDC patients, and highly related with the duration of IDC patients,P <0.05. No correlation was found between the Slit2 expression and the tumor size, lymph node metastasis, pathologic stage and histological grade, P > 0.05. Conclusion The Slit2 expression correlates negatively with IDC brain metastasis, and positively with the age and duration of IDC patients. Slit2 could be applied as a marker in evaluating the IDC invasiveness and brain metastasis, and could be a new therapeutic target.%目的 检测神经轴突导向蛋白2(Slit2)在不同乳腺肿瘤组织中的表达,探讨Slit2与乳腺癌脑转移的相关性.方法 采用免疫组织化学LSAB法检测对24例发生脑转移的乳腺浸润性导管癌(IDC)、71例未发生脑转移的乳腺浸润性导管癌、22例乳腺导管内癌和23例乳腺腺纤维瘤组织中Slit2的表达.结果 Slit2在浸润性导管癌中有脑转移患者的阳性表达率(13%)明显低于无脑转移患者(59%)(P<0.05);在乳腺导管内癌和浸润性导管癌中的阳性表达率(59%和48%)