Sample records for address scientific challenges
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Addressing big data challenges for scientific data infrastructure
Demchenko, Y.; Zhao, Z.; Grosso, P.; Wibisono, A.; de Laat, C.
2012-01-01
This paper discusses the challenges that are imposed by Big Data Science on the modern and future Scientific Data Infrastructure (SDI). The paper refers to different scientific communities to define requirements on data management, access control and security. The paper introduces the Scientific
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Efstathiou, Sophia
2016-04-01
This paper argues that challenges that are grand in scope such as "lifelong health and wellbeing", "climate action", or "food security" cannot be addressed through scientific research only. Indeed scientific research could inhibit addressing such challenges if scientific analysis constrains the multiple possible understandings of these challenges into already available scientific categories and concepts without translating between these and everyday concerns. This argument builds on work in philosophy of science and race to postulate a process through which non-scientific notions become part of science. My aim is to make this process available to scrutiny: what I call founding everyday ideas in science is both culturally and epistemologically conditioned. Founding transforms a common idea into one or more scientifically relevant ones, which can be articulated into descriptively thicker and evaluatively deflated terms and enable operationalisation and measurement. The risk of founding however is that it can invisibilise or exclude from realms of scientific scrutiny interpretations that are deemed irrelevant, uninteresting or nonsensical in the domain in question-but which may remain salient for addressing grand-in-scope challenges. The paper considers concepts of "wellbeing" in development economics versus in gerontology to illustrate this process. Copyright © 2015 Elsevier Ltd. All rights reserved.
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Scientific Challenges for Understanding the Quantum Universe
Energy Technology Data Exchange (ETDEWEB)
Khaleel, Mohammad A.
2009-10-16
A workshop titled "Scientific Challenges for Understanding the Quantum Universe" was held December 9-11, 2008, at the Kavli Institute for Particle Astrophysics and Cosmology at the Stanford Linear Accelerator Center-National Accelerator Laboratory. The primary purpose of the meeting was to examine how computing at the extreme scale can contribute to meeting forefront scientific challenges in particle physics, particle astrophysics and cosmology. The workshop was organized around five research areas with associated panels. Three of these, "High Energy Theoretical Physics," "Accelerator Simulation," and "Experimental Particle Physics," addressed research of the Office of High Energy Physics’ Energy and Intensity Frontiers, while the"Cosmology and Astrophysics Simulation" and "Astrophysics Data Handling, Archiving, and Mining" panels were associated with the Cosmic Frontier.
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Scientific data management challenges, technology and deployment
Rotem, Doron
2010-01-01
Dealing with the volume, complexity, and diversity of data currently being generated by scientific experiments and simulations often causes scientists to waste productive time. Scientific Data Management: Challenges, Technology, and Deployment describes cutting-edge technologies and solutions for managing and analyzing vast amounts of data, helping scientists focus on their scientific goals. The book begins with coverage of efficient storage systems, discussing how to write and read large volumes of data without slowing the simulation, analysis, or visualization processes. It then focuses on the efficient data movement and management of storage spaces and explores emerging database systems for scientific data. The book also addresses how to best organize data for analysis purposes, how to effectively conduct searches over large datasets, how to successfully automate multistep scientific process workflows, and how to automatically collect metadata and lineage information. This book provides a comprehensive u...
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Fostering Scientific Literacy: Establishing Social Relevance via the Grand Challenges
Lyford, M. E.; Myers, J. D.; Buss, A.
2010-12-01
Numerous studies and polls suggest the general public’s understanding of science and scientific literacy remain woefully inadequate despite repeated calls for improvement over the last 150 years. This inability to improve scientific literacy significantly is a complex problem likely driven by a number of factors. However, we argue that past calls and efforts for improving scientific literacy have failed to: 1) articulate a truly meaningful justification for society to foster a scientifically literate public; 2) provide a rationale that motivates individuals of diverse backgrounds to become scientifically literate; 3) consider the impact of personal perspective, e.g. values, beliefs, attitudes, etc., on learning; and 4) offer a relevant and manageable framework in which to define scientific literacy. For instance, past calls for improving scientific literacy, e.g. the U.S. is behind the Soviets in the space race, U.S students rank below country X in math and science, etc., have lacked justification, personal motivation and a comprehensive framework for defining scientific literacy. In these cases, the primary justification for improving science education and scientific literacy was to regain international dominance in the space race or to advance global standing according to test results. These types of calls also articulate short-term goals that are rendered moot once they have been achieved. At the same time, teaching practices have commonly failed to consider the perspectives students bring to the classroom. Many STEM faculty do not address issues of personal perspective through ignorance or the desire to avoid controversial subjects, e g. evolution, climate change. We propose that the ‘grand challenges’ (e.g., energy, climate change, antibacterial resistance, water, etc.) humankind currently faces provides a compelling framework for developing courses and curricula well-suited for improving scientific literacy. A grand challenge paradigm offers four
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Energy Technology Data Exchange (ETDEWEB)
Khaleel, Mohammad A.
2011-02-06
The goal of the "Scientific Grand Challenges - Crosscutting Technologies for Computing at the Exascale" workshop in February 2010, jointly sponsored by the U.S. Department of Energy’s Office of Advanced Scientific Computing Research and the National Nuclear Security Administration, was to identify the elements of a research and development agenda that will address these challenges and create a comprehensive exascale computing environment. This exascale computing environment will enable the science applications identified in the eight previously held Scientific Grand Challenges Workshop Series.
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Addressing submarine geohazards through scientific drilling
Camerlenghi, A.
2009-04-01
Natural submarine geohazards (earthquakes, volcanic eruptions, landslides, volcanic island flank collapses) are geological phenomena originating at or below the seafloor leading to a situation of risk for off-shore and on-shore structures and the coastal population. Addressing submarine geohazards means understanding their spatial and temporal variability, the pre-conditioning factors, their triggers, and the physical processes that control their evolution. Such scientific endeavour is nowadays considered by a large sector of the international scientific community as an obligation in order to contribute to the mitigation of the potentially destructive societal effects of submarine geohazards. The study of submarine geohazards requires a multi-disciplinary scientific approach: geohazards must be studied through their geological record; active processes must be monitored; geohazard evolution must be modelled. Ultimately, the information must be used for the assessment of vulnerability, risk analysis, and development of mitigation strategies. In contrast with the terrestrial environment, the oceanic environment is rather hostile to widespread and fast application of high-resolution remote sensing techniques, accessibility for visual inspection, sampling and installation of monitoring stations. Scientific Drilling through the IODP (including the related pre site-survey investigations, sampling, logging and in situ measurements capability, and as a platform for deployment of long term observatories at the surface and down-hole) can be viewed as the centre of gravity of an international, coordinated, multi-disciplinary scientific approach to address submarine geohazards. The IODP Initial Science Plan expiring in 2013 does not address openly geohazards among the program scientific objectives. Hazards are referred to mainly in relation to earthquakes and initiatives towards the understanding of seismogenesis. Notably, the only drilling initiative presently under way is the
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Scientific foundations of addressing risk in complex and dynamic environments
International Nuclear Information System (INIS)
Grotan, T.O.; Storseth, F.; Albrechtsen, E.
2011-01-01
Development, deployment and application of Information and Communication Technology (ICT) and digital infrastructure continue with unabated intensity in the petroleum-related activity on the Norwegian shelf. This development towards what is denoted Integrated Operations (IO) creates new ways of organizing work, new work processes and increased automation, e.g. closer collaboration offshore-onshore, cooperation across organizational and geographical borders. This creates new challenges for managing risk. Although there are different versions of IO today, we argue that it is possible to identify and study generic properties within such IO manifestations. The current paper focus on the potential complexity of IO in the generic sense, and some scientific implications in terms of addressing risk. The paper uses the century-old metaphor of 'wildness in wait' to engage the wide field of complexity theory in a productive way to address systemic properties of risk. The paper further uses the Cynefin sensemaking framework in order to identify and address the crucial distinction between directed (resultant) and un-directed (emergent) order. The paper finally discusses the importance of seeing risk assessment as a social knowledge practice.
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Scientific and social challenges for the management of fire-prone wildland-urban interfaces
Gill, A. Malcolm; Stephens, Scott L.
2009-09-01
At their worst, fires at the rural-urban or wildland-urban interface cause tragic loss of human lives and homes, but mitigating these fire effects through management elicits many social and scientific challenges. This paper addresses four interconnected management challenges posed by socially disastrous landscape fires. The issues concern various assets (particularly houses, human life and biodiversity), fuel treatments, and fire and human behaviours. The topics considered are: 'asset protection zones'; 'defensible space' and urban fire spread in relation to house ignition and loss; 'stay-or-go' policy and the prediction of time available for safe egress and the possible conflict between the creation of defensible space and wildland management objectives. The first scientific challenge is to model the effective width of an asset protection zone of an urban area. The second is to consider the effect of vegetation around a house, potentially defensible space, on fire arrival at the structure. The third scientific challenge is to present stakeholders with accurate information on rates of spread, and where the fire front is located, so as to allow them to plan safe egress or preparation time in their particular circumstances. The fourth scientific challenge is to be able to predict the effects of fires on wildland species composition. Associated with each scientific challenge is a social challenge: for the first two scientific challenges the social challenge is to co-ordinate fuel management within and between the urban and rural or wildland sides of the interface. For the third scientific challenge, the social challenge is to be aware of, and appropriately use, fire danger information so that the potential for safe egress from a home can be estimated most accurately. Finally, the fourth social challenge is to for local residents of wildland-urban interfaces with an interest in biodiversity conservation to understand the effects of fire regimes on biodiversity, thereby
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Scientific and social challenges for the management of fire-prone wildland-urban interfaces
International Nuclear Information System (INIS)
Gill, A Malcolm; Stephens, Scott L
2009-01-01
At their worst, fires at the rural-urban or wildland-urban interface cause tragic loss of human lives and homes, but mitigating these fire effects through management elicits many social and scientific challenges. This paper addresses four interconnected management challenges posed by socially disastrous landscape fires. The issues concern various assets (particularly houses, human life and biodiversity), fuel treatments, and fire and human behaviours. The topics considered are: 'asset protection zones'; 'defensible space' and urban fire spread in relation to house ignition and loss; 'stay-or-go' policy and the prediction of time available for safe egress and the possible conflict between the creation of defensible space and wildland management objectives. The first scientific challenge is to model the effective width of an asset protection zone of an urban area. The second is to consider the effect of vegetation around a house, potentially defensible space, on fire arrival at the structure. The third scientific challenge is to present stakeholders with accurate information on rates of spread, and where the fire front is located, so as to allow them to plan safe egress or preparation time in their particular circumstances. The fourth scientific challenge is to be able to predict the effects of fires on wildland species composition. Associated with each scientific challenge is a social challenge: for the first two scientific challenges the social challenge is to co-ordinate fuel management within and between the urban and rural or wildland sides of the interface. For the third scientific challenge, the social challenge is to be aware of, and appropriately use, fire danger information so that the potential for safe egress from a home can be estimated most accurately. Finally, the fourth social challenge is to for local residents of wildland-urban interfaces with an interest in biodiversity conservation to understand the effects of fire regimes on biodiversity, thereby
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Molecular Science Computing Facility Scientific Challenges: Linking Across Scales
Energy Technology Data Exchange (ETDEWEB)
De Jong, Wibe A.; Windus, Theresa L.
2005-07-01
The purpose of this document is to define the evolving science drivers for performing environmental molecular research at the William R. Wiley Environmental Molecular Sciences Laboratory (EMSL) and to provide guidance associated with the next-generation high-performance computing center that must be developed at EMSL's Molecular Science Computing Facility (MSCF) in order to address this critical research. The MSCF is the pre-eminent computing facility?supported by the U.S. Department of Energy's (DOE's) Office of Biological and Environmental Research (BER)?tailored to provide the fastest time-to-solution for current computational challenges in chemistry and biology, as well as providing the means for broad research in the molecular and environmental sciences. The MSCF provides integral resources and expertise to emerging EMSL Scientific Grand Challenges and Collaborative Access Teams that are designed to leverage the multiple integrated research capabilities of EMSL, thereby creating a synergy between computation and experiment to address environmental molecular science challenges critical to DOE and the nation.
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Cooper, Susan J.
The purpose of this study was to interpret the experiences of secondary science teachers in Florida as they address the scientific literacy of their students through teaching content reading strategies and student inquiry skills. Knowledge of the successful integration of content reading and inquiry skills by experienced classroom teachers would be useful to many educators as they plan instruction to achieve challenging state and national standards for reading as well as science. The problem was investigated using grounded theory methodology. Open-ended questions were asked in three focus groups and six individual interviews that included teachers from various Florida school districts. The constant comparative approach was used to analyze the data. Initial codes were collapsed into categories to determine the conceptual relationships among the data. From this, the five core categories were determined to be Influencers, Issues, Perceptions, Class Routines, and Future Needs. These relate to the central phenomenon, Instructional Modifications, because teachers often described pragmatic and philosophical changes in their teaching as they deliberated to meet state standards in both reading and science. Although Florida's secondary science teachers have been asked to incorporate content reading strategies into their science instruction for the past several years, there was limited evidence of using these strategies to further student understanding of scientific processes. Most teachers saw little connection between reading and inquiry, other than the fact that students must know how to read to follow directions in the lab. Scientific literacy, when it was addressed by teachers, was approached mainly through class discussions, not reading. Teachers realized that students cannot learn secondary science content unless they read science text with comprehension; therefore the focus of reading instruction was on learning science content, not scientific literacy or student
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Amarasingham, Ruben; Audet, Anne-Marie J; Bates, David W; Glenn Cohen, I; Entwistle, Martin; Escobar, G J; Liu, Vincent; Etheredge, Lynn; Lo, Bernard; Ohno-Machado, Lucila; Ram, Sudha; Saria, Suchi; Schilling, Lisa M; Shahi, Anand; Stewart, Walter F; Steyerberg, Ewout W; Xie, Bin
2016-01-01
The recent explosion in available electronic health record (EHR) data is motivating a rapid expansion of electronic health care predictive analytic (e-HPA) applications, defined as the use of electronic algorithms that forecast clinical events in real time with the intent to improve patient outcomes and reduce costs. There is an urgent need for a systematic framework to guide the development and application of e-HPA to ensure that the field develops in a scientifically sound, ethical, and efficient manner. Building upon earlier frameworks of model development and utilization, we identify the emerging opportunities and challenges of e-HPA, propose a framework that enables us to realize these opportunities, address these challenges, and motivate e-HPA stakeholders to both adopt and continuously refine the framework as the applications of e-HPA emerge. To achieve these objectives, 17 experts with diverse expertise including methodology, ethics, legal, regulation, and health care delivery systems were assembled to identify emerging opportunities and challenges of e-HPA and to propose a framework to guide the development and application of e-HPA. The framework proposed by the panel includes three key domains where e-HPA differs qualitatively from earlier generations of models and algorithms (Data Barriers, Transparency, and ETHICS) and areas where current frameworks are insufficient to address the emerging opportunities and challenges of e-HPA (Regulation and Certification; and Education and Training). The following list of recommendations summarizes the key points of the framework: Data Barriers: Establish mechanisms within the scientific community to support data sharing for predictive model development and testing.Transparency: Set standards around e-HPA validation based on principles of scientific transparency and reproducibility. Develop both individual-centered and society-centered risk-benefit approaches to evaluate e-HPA.Regulation and Certification: Construct a
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Addressing Unconscious Bias: Steps toward an Inclusive Scientific Culture
Stewart, Abigail
2011-01-01
In this talk I will outline the nature of unconscious bias, as it operates to exclude or marginalize some participants in the scientific community. I will show how bias results from non-conscious expectations about certain groups of people, including scientists and astronomers. I will outline scientific research in psychology, sociology and economics that has identified the impact these expectations have on interpersonal judgments that are at the heart of assessment of individuals' qualifications. This research helps us understand not only how bias operates within a single instance of evaluation, but how evaluation bias can accumulate over a career if not checked, creating an appearance of confirmation of biased expectations. Some research has focused on how best to interrupt and mitigate unconscious bias, and many institutions--including the University of Michigan--have identified strategic interventions at key points of institutional decision-making (particularly hiring, annual review, and promotion) that can make a difference. The NSF ADVANCE Institutional Transformation program encouraged institutions to draw on the social science literature to create experimental approaches to addressing unconscious bias. I will outline four approaches to intervention that have arisen through the ADVANCE program: (1) systematic education that increases awareness among decisionmakers of how evaluation bias operates; (2) development of practices that mitigate the operation of bias even when it is out of conscious awareness; (3) creation of institutional policies that routinize and sanction these practices; and (4) holding leaders accountable for these implementation of these new practices and policies. Although I will focus on ways to address unconscious bias within scientific institutions (colleges and universities, laboratories and research centers, etc.), I will close by considering how scientific organizations can address unconscious bias and contribute to creating an
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Directory of Open Access Journals (Sweden)
Tammy R. Dugas
2016-06-01
Full Text Available Airborne fine and ultrafine particulate matter (PM are often generated through widely-used thermal processes such as the combustion of fuels or the thermal decomposition of waste. Residents near Superfund sites are exposed to PM through the inhalation of windblown dust, ingestion of soil and sediments, and inhalation of emissions from the on-site thermal treatment of contaminated soils. Epidemiological evidence supports a link between exposure to airborne PM and an increased risk of cardiovascular and pulmonary diseases. It is well-known that during combustion processes, incomplete combustion can lead to the production of organic pollutants that can adsorb to the surface of PM. Recent studies have demonstrated that their interaction with metal centers can lead to the generation of a surface stabilized metal-radical complex capable of redox cycling to produce ROS. Moreover, these free radicals can persist in the environment, hence their designation as Environmentally Persistent Free Radicals (EPFR. EPFR has been demonstrated in both ambient air PM2.5 (diameter < 2.5 µm and in PM from a variety of combustion sources. Thus, low-temperature, thermal treatment of soils can potentially increase the concentration of EPFR in areas in and around Superfund sites. In this review, we will outline the evidence to date supporting EPFR formation and its environmental significance. Furthermore, we will address the lack of methodologies for specifically addressing its risk assessment and challenges associated with regulating this new, emerging contaminant.
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Time for a change: addressing R&D and commercialization challenges for antibacterials
Payne, David J.; Miller, Linda Federici; Findlay, David; Anderson, James; Marks, Lynn
2015-01-01
The antibacterial therapeutic area has been described as the perfect storm. Resistance is increasing to the point that our hospitals encounter patients infected with untreatable pathogens, the overall industry pipeline is described as dry and most multinational pharmaceutical companies have withdrawn from the area. Major contributing factors to the declining antibacterial industry pipeline include scientific challenges, clinical/regulatory hurdles and low return on investment. This paper examines these challenges and proposes approaches to address them. There is a need for a broader scientific agenda to explore new approaches to discover and develop antibacterial agents. Additionally, ideas of how industry and academia could be better integrated will be presented. While promising progress in the regulatory environment has been made, more streamlined regulatory paths are still required and the solutions will lie in global harmonization and clearly defined guidance. Creating the right incentives for antibacterial research and development is critical and a new commercial model for antibacterial agents will be proposed. One key solution to help resolve both the problem of antimicrobial resistance (AMR) and lack of new drug development are rapid, cost-effective, accurate point of care diagnostics that will transform antibacterial prescribing and enable more cost-effective and efficient antibacterial clinical trials. The challenges of AMR are too great for any one group to resolve and success will require leadership and partnerships among academia, industry and governments globally. PMID:25918443
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Addressing big data issues in Scientific Data Infrastructure
Demchenko, Y.; Membrey, P.; Grosso, P.; de Laat, C.; Smari, W.W.; Fox, G.C.
2013-01-01
Big Data are becoming a new technology focus both in science and in industry. This paper discusses the challenges that are imposed by Big Data on the modern and future Scientific Data Infrastructure (SDI). The paper discusses a nature and definition of Big Data that include such features as Volume,
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Scientific and technical challenges of radioactive waste management
International Nuclear Information System (INIS)
Vira, J.
1996-01-01
In spite of considerable spending on research and technical development, the management of nuclear wastes continues to be a difficult issue in public decision making. The nuclear industry says that it has safe solutions for the ultimate disposal of nuclear wastes, but the message has not really got through to the public at large. Although communications problems reflect the general stigmatization of nuclear power, there are obvious issues in safety and performance assessment of nuclear waste disposal which evade scientific resolution. Any scientist is concerned for his personal credibility must respect the rules and limits of scientific practice, but the intriguing question is whether he would not do better to address the layman's worries about radioactive substances? The discussion in this paper points out the intricacies of the distinction between scientific proof and judgement, with emphasis on safety assessment for nuclear waste disposal. Who are the final arbitrators? In a democratic society it is probably those who vote.Building confidence in expert judgements is a challenge for waste managers and scientists. The media may create their own 'experts', whose only necessary credential is the trust of their audience, but scientific judgements must stand the test of time.'Confidence building' is currently a key word on the whole nuclear waste management scene, and confidence in science and scientists is certainly needed for any progress towards practical implementation of plans. The means for building confidence in the decision-making process are probably different from those applied for science and scientists. (author)
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Activities to Address Challenges in Digital Innovation
Lund , Jesper
2014-01-01
Part 3: Structures and Networks; International audience; Based on a literature review, this paper identifies four socio-technical challenges relating to innovation actor’s interactions in digital innovation. Furthermore, the paper explores how these challenges can be addressed. The challenges are investigated in a case study of digital innovation. The study is based on a two year long research and development project where an e-newspaper concept and a demonstrator based on e-paper technology ...
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Addressing challenges to MMPI-2-RF-based testimony: questions and answers.
Ben-Porath, Yossef S
2012-11-01
Introduction of a new version of a psychological test brings with it challenges that can be accentuated by the adversarial nature of the legal process. In the case of the Minnesota Multiphasic Personality Inventory-2 Restructured Form (MMPI-2-RF), these challenges can be addressed by becoming familiar with the rationale for and the methods used in revising the inventory, the information contained in the test manuals, and the growing peer-reviewed literature on the test. Potential challenges to MMPI-2-RF-based testimony are identified in this article and discussed in question and answer format. The questions guiding this discussion are based on the Daubert factors, established in 1993 by the US Supreme Court as criteria for gauging the scientific validity of proffered expert testimony. The answers to these questions apply more broadly to testimony in depositions, pre-trial hearings, and at trial. Consideration of the MMPI-2-RF in light of the Daubert factors indicates that the instrument has been subjected to extensive empirical testing and that a substantial peer-reviewed literature is available to guide and support its use. Information about the known and potential rate of error associated with MMPI-2-RF scores is available, and standard procedures for administration, scoring, and interpretation of the inventory are detailed in the test administration manual. Indicators of MMPI-2-RF acceptance can be cited, and criticisms of the MMPI-2-RF can be addressed with information available in the test documents and an extensive, modern, and actively growing peer-reviewed literature.
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Authorship for scientific papers: the new challenges.
Garcia, Carla Costa; Martrucelli, Cristina Ribeiro Nabuco; Rossilho, Marilisa de Melo Freire; Denardin, Odilon Victor Porto
2010-01-01
The dissemination of the practice of collaborative authorship (coauthorship) in Brazil and in the international scientific community has been accompanied by an increasing occurrence of frauds, manipulations and other deviations in the assignment of responsibility for a scientific paper. This article discusses the criteria for authorship attribution, the reasons for the growing indices of coauthorship and the challenges to determine authorship in electronic journals. Through literature review and case study (bibliographic search in scientific database), it shows ways to avoid that "misbehaviors" related to the authorship attribution affect the credibility of science.
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Gundersen, Linda C.; Townsend, Randy
2017-01-01
Creating an ethics policy for a large, diverse geosciences organization is a challenge, especially in the midst of the current contentious dialogue in the media related to such issues as climate change, sustaining natural resources, and responding to natural hazards. In 2011, the American Geophysical Union (AGU) took on this challenge, creating an Ethics Task Force to update their ethics policies to better support their new Strategic Plan and respond to the changing scientific research environment. Dialogue with AGU members and others during the course of creating the new policy unveiled some of the following issues to be addressed. Scientific results and individual scientists are coming under intense political and public scrutiny, with the efficacy of the science being questioned. In some cases, scientists are asked to take sides and/or provide opinions on issues beyond their research, impacting their objectivity. Pressure related to competition for funding and the need to publish high quality and quantities of papers has led to recent high profile plagiarism, data fabrication, and conflict of interest cases. The complexities of a continuously advancing digital environment for conducting, reviewing, and publishing science has raised concerns over the ease of plagiarism, fabrication, falsification, inappropriate peer review, and the need for better accessibility of data and methods. Finally, students and scientists need consistent education and encouragement on the importance of ethics and integrity in scientific research. The new AGU Scientific Integrity and Ethics Policy tries to address these issues and provides an inspirational code of conduct to encourage a responsible, positive, open, and honest scientific research environment.
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CIRM Alpha Stem Cell Clinics: Collaboratively Addressing Regenerative Medicine Challenges.
Jamieson, Catriona H M; Millan, Maria T; Creasey, Abla A; Lomax, Geoff; Donohoe, Mary E; Walters, Mark C; Abedi, Mehrdad; Bota, Daniela A; Zaia, John A; Adams, John S
2018-06-01
The California Institute for Regenerative Medicine (CIRM) Alpha Stem Cell Clinic (ASCC) Network was launched in 2015 to address a compelling unmet medical need for rigorous, FDA-regulated, stem cell-related clinical trials for patients with challenging, incurable diseases. Here, we describe our multi-center experiences addressing current and future challenges. Copyright © 2018 Elsevier Inc. All rights reserved.
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Using ICTs to Address Water Challenges in Uganda | IDRC ...
International Development Research Centre (IDRC) Digital Library (Canada)
Using ICTs to Address Water Challenges in Uganda ... the adaptive capacity of communities to address the issue of climate-induced water stress. ... It will do so by testing the electronic dissemination of seasonal forecasts, early warning ...
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Addressing the workforce pipeline challenge
Energy Technology Data Exchange (ETDEWEB)
Leonard Bond; Kevin Kostelnik; Richard Holman
2006-11-01
A secure and affordable energy supply is essential for achieving U.S. national security, in continuing U.S. prosperity and in laying the foundations to enable future economic growth. To meet this goal the next generation energy workforce in the U.S., in particular those needed to support instrumentation, controls and advanced operations and maintenance, is a critical element. The workforce is aging and a new workforce pipeline, to support both current generation and new build has yet to be established. The paper reviews the challenges and some actions being taken to address this need.
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Enabling a new Paradigm to Address Big Data and Open Science Challenges
Ramamurthy, Mohan; Fisher, Ward
2017-04-01
Data are not only the lifeblood of the geosciences but they have become the currency of the modern world in science and society. Rapid advances in computing, communi¬cations, and observational technologies — along with concomitant advances in high-resolution modeling, ensemble and coupled-systems predictions of the Earth system — are revolutionizing nearly every aspect of our field. Modern data volumes from high-resolution ensemble prediction/projection/simulation systems and next-generation remote-sensing systems like hyper-spectral satellite sensors and phased-array radars are staggering. For example, CMIP efforts alone will generate many petabytes of climate projection data for use in assessments of climate change. And NOAA's National Climatic Data Center projects that it will archive over 350 petabytes by 2030. For researchers and educators, this deluge and the increasing complexity of data brings challenges along with the opportunities for discovery and scientific breakthroughs. The potential for big data to transform the geosciences is enormous, but realizing the next frontier depends on effectively managing, analyzing, and exploiting these heterogeneous data sources, extracting knowledge and useful information from heterogeneous data sources in ways that were previously impossible, to enable discoveries and gain new insights. At the same time, there is a growing focus on the area of "Reproducibility or Replicability in Science" that has implications for Open Science. The advent of cloud computing has opened new avenues for not only addressing both big data and Open Science challenges to accelerate scientific discoveries. However, to successfully leverage the enormous potential of cloud technologies, it will require the data providers and the scientific communities to develop new paradigms to enable next-generation workflows and transform the conduct of science. Making data readily available is a necessary but not a sufficient condition. Data providers
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Addressing Safeguards Challenges for the Future
Energy Technology Data Exchange (ETDEWEB)
Majali, Raed; Yim, Man-Sung [Korea Advanced Institute of Science and Technology, Daejeon (Korea, Republic of)
2015-10-15
IAEA safeguard system is considered the corner stone of the international nuclear nonproliferation regime. Effective implementation of this legal instrument enables the IAEA to draw a conclusion with a high degree of confidence on the peaceful use of nuclear material and activities in the state. This paper aims to provide an opportunity to address various challenges encountered by IAEA. Strengthening safeguards system for verification is one of the most urgent challenges facing the IAEA. The IAEA should be able to provide credible assurance not only about declared use of nuclear material and facilities but also about the absence of undeclared material and activities. Implementation of IAEA safeguards continue to play a vital role within the nuclear non-proliferation regime. IAEA must move towards more enhanced safeguards system that is driven by the full use of all the safeguards available relevant information. Safeguards system must be responsive to evolving challenges and continue innovation through efficient implementations of more effective safeguards.
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Cooperation of international Research Infrastructures to address environmental global challenges
Bonet García, Francisco J.; Suárez-Muñoz, María; Conchubhair, Diarmuid O.; Dohna, Tina; Lo Bue, Nadia
2017-04-01
participating RIs regarding each GC. Moreover, it is expected that the outcomes of this work will encourage and promote project participants and stakeholders, as well as the general public to take action with regard to the challenges and solutions outlined by the GC descriptions. This task of describing GCs is an open initiative: all input is welcome. To input with any suggestions, please send an email to info@coop-plus.eu. This contribution presents the preliminary results obtained during the description of the selected GC's under the point of view of RIs: - Template used to describe all GC in a standardized way. It contains several sections regarding topics such as: rationale of the challenge, identification of scientific/technical/social needs, role of RIs in the GC, tasks to be done (data collection, experimental research, modelling, dissemination), etc. - Configuration of working teams designed to describe the GCs. Each GC has a person in charge who is responsible of coordinating the writing process. The working team is composed by scientists experts in each challenge, experts in thematic RIs (within EU and abroad), policy makers and other stakeholders. The results obtained by this description task will be published in a special issue in a Geoscience journal. The writing teams are expected to become project consortia willing to participate in specific calls to address GCs.
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Innovative approaches for addressing old challenges in component importance measures
International Nuclear Information System (INIS)
Rocco S, Claudio M.; Ramirez-Marquez, Jose Emmanuel
2012-01-01
Importance measures (IM) are component related indices that allow assessing how a component in a system affects one or more system level performance functions. While several IM have been presented in the literature, challenges still remain with respect to the following: (1) multiple ranking—multiple perspective, (2) multi-component importance and, (3) multi-function importance. To address these challenges, this paper proposes set of innovative solutions based on several available techniques: Hasse diagram, Copeland score and Multi-objective optimization. As such, the purpose of this research is twofold: first propose solutions and second foster new research to address these challenges. Each of the proposed solutions is exemplified with a working example.
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HEP technologies to address medical imaging challenges
CERN. Geneva
2016-01-01
Developments in detector technologies aimed at solving challenges in present and future CERN experiments, particularly at the LHC, have triggered exceptional advances in the performance of medical imaging devices, allowing for a spectacular progress in in-vivo molecular imaging procedures, which are opening the way for tailored therapies of major diseases. This talk will briefly review the recent history of this prime example of technology transfer from HEP experiments to society, will describe the technical challenges being addressed by some ongoing projects, and will present a few new ideas for further developments and their foreseeable impact.
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Use of new scientific developments in regulatory risk assessments: challenges and opportunities.
Tarazona, Jose V
2013-07-01
Since the 1990s, science based ecological risk assessments constitute an essential tool for supporting decision making in the regulatory context. Using the European REACH Regulation as example, this article presents the challenges and opportunities for new scientific developments within the area of chemical control and environmental protection. These challenges can be sorted out in 3 main related topics (sets). In the short term, the challenges are directly associated with the regulatory requirements, required for facilitating a scientifically sound implementation of the different obligations for industry and authorities. It is important to mention that although the actual tools are different due to the regulatory requirements, the basic needs are still the same as those addressed in the early 1990s: understanding the ecological relevance of the predicted effects, including the uncertainty, and facilitating the link with the socio-economic assessment. The second set of challenges covers the opportunities for getting an added value from the regulatory efforts. The information compiled through REACH registration and notification processes is analyzed as source for new integrative developments for assessing the combined chemical risk at the regional level. Finally, the article discusses the challenge of inverting the process and developing risk assessment methods focusing on the receptor, the individual or ecosystem, instead of on the stressor or source. These approaches were limited in the past due to the lack of information, but the identification and dissemination of standard information, including uses, manufacturing sites, physical-chemical, environmental, ecotoxicological, and toxicological properties as well as operational conditions and risk management measures for thousands of chemicals, combined by the knowledge gathered through large scale monitoring programs and spatial information systems is generating new opportunities. The challenge is liking
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Using ICTs to Address Water Challenges in Uganda | CRDI - Centre ...
International Development Research Centre (IDRC) Digital Library (Canada)
15 janv. 2012 ... Using ICTs to Address Water Challenges in Uganda ... adaptive capacity of communities to address the issue of climate-induced water stress. ... It will do so by testing the electronic dissemination of seasonal forecasts, early ...
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Scientific and Computational Challenges of the Fusion Simulation Program (FSP)
International Nuclear Information System (INIS)
Tang, William M.
2011-01-01
This paper highlights the scientific and computational challenges facing the Fusion Simulation Program (FSP) a major national initiative in the United States with the primary objective being to enable scientific discovery of important new plasma phenomena with associated understanding that emerges only upon integration. This requires developing a predictive integrated simulation capability for magnetically-confined fusion plasmas that are properly validated against experiments in regimes relevant for producing practical fusion energy. It is expected to provide a suite of advanced modeling tools for reliably predicting fusion device behavior with comprehensive and targeted science-based simulations of nonlinearly-coupled phenomena in the core plasma, edge plasma, and wall region on time and space scales required for fusion energy production. As such, it will strive to embody the most current theoretical and experimental understanding of magnetic fusion plasmas and to provide a living framework for the simulation of such plasmas as the associated physics understanding continues to advance over the next several decades. Substantive progress on answering the outstanding scientific questions in the field will drive the FSP toward its ultimate goal of developing the ability to predict the behavior of plasma discharges in toroidal magnetic fusion devices with high physics fidelity on all relevant time and space scales. From a computational perspective, this will demand computing resources in the petascale range and beyond together with the associated multi-core algorithmic formulation needed to address burning plasma issues relevant to ITER - a multibillion dollar collaborative experiment involving seven international partners representing over half the world's population. Even more powerful exascale platforms will be needed to meet the future challenges of designing a demonstration fusion reactor (DEMO). Analogous to other major applied physics modeling projects (e
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Scientific and computational challenges of the fusion simulation program (FSP)
International Nuclear Information System (INIS)
Tang, William M.
2011-01-01
This paper highlights the scientific and computational challenges facing the Fusion Simulation Program (FSP) - a major national initiative in the United States with the primary objective being to enable scientific discovery of important new plasma phenomena with associated understanding that emerges only upon integration. This requires developing a predictive integrated simulation capability for magnetically-confined fusion plasmas that are properly validated against experiments in regimes relevant for producing practical fusion energy. It is expected to provide a suite of advanced modeling tools for reliably predicting fusion device behavior with comprehensive and targeted science-based simulations of nonlinearly-coupled phenomena in the core plasma, edge plasma, and wall region on time and space scales required for fusion energy production. As such, it will strive to embody the most current theoretical and experimental understanding of magnetic fusion plasmas and to provide a living framework for the simulation of such plasmas as the associated physics understanding continues to advance over the next several decades. Substantive progress on answering the outstanding scientific questions in the field will drive the FSP toward its ultimate goal of developing the ability to predict the behavior of plasma discharges in toroidal magnetic fusion devices with high physics fidelity on all relevant time and space scales. From a computational perspective, this will demand computing resources in the petascale range and beyond together with the associated multi-core algorithmic formulation needed to address burning plasma issues relevant to ITER - a multibillion dollar collaborative experiment involving seven international partners representing over half the world's population. Even more powerful exascale platforms will be needed to meet the future challenges of designing a demonstration fusion reactor (DEMO). Analogous to other major applied physics modeling projects (e
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The Data Issue: Opportunities and Challenges for Scientific Publishers
Murphy, F.; Irving, D. H.
2011-12-01
Using the recent report for the 'Opportunities in Data Exchange' Project produced by - and for - researchers, libraries/data centres and publishers (and which is based on a broad range of studies, questionnaires and evidence) we have defined current practices and expectations, and the gaps and dilemmas involved in producing data and datasets, and then analysed their relationship to formal publications. As a result, we identified potential opportunities to evolve scientific insights to be more useful and re-useful: with consequent implications for custodianship and long-term data management. We also defined a number of key incentives and barriers towards achieving these objectives. As a case study, the earth and environmental sciences have come under particularly close scrutiny with respect to data-ownership and -sharing arrangements, sometimes with damaging results to the discipline's reputation. These issues, along with considerable technological challenges, have to be handled effectively in order to best support all the users along the data chain. To that end, we show that key stakeholders - among them scientific publishers - need to have a clear idea of how to progress data-intensive derived information, which we demonstrate is often not the case. Towards bridging this knowledge gap, we have compiled a roadmap of next steps and key issues to be acknowledged and addressed by the scientific publishing community. These include: engaging directly with researchers, policy-makers, funding bodies and direct competitors to build innovative partnerships and enhance impact; providing technological and training investment and developing alongside the emerging discipline of 'data scientist': the 'data publisher'. This individual/company will need to combine a close understanding of researchers' priorities, together with market, legal and technical opportunities and restrictions.
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CERN openlab Whitepaper on Future IT Challenges in Scientific Research
Di Meglio, Alberto; Purcell, Andrew
2014-01-01
This whitepaper describes the major IT challenges in scientific research at CERN and several other European and international research laboratories and projects. Each challenge is exemplified through a set of concrete use cases drawn from the requirements of large-scale scientific programs. The paper is based on contributions from many researchers and IT experts of the participating laboratories and also input from the existing CERN openlab industrial sponsors. The views expressed in this document are those of the individual contributors and do not necessarily reflect the view of their organisations and/or affiliates.
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Challenges facing the marketing of scientific and research institutes
Bogdan Sojkin
2015-01-01
This article presents the challenges that scientific research institutions face in terms of their marketing, which have been divided into two groups of those associated with internal marketing and those linked to external marketing. The most significant and important determinants that constitute challenges to both internal and external marketing were described. The key aspects of each of the identified challenges were indicated, as was their impact on the implementation of the marketing polic...
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Megacities and Large Urban Complexes - WMO Role in Addressing Challenges and Opportunities
Terblanche, Deon; Jalkanen, Liisa
2013-04-01
counterparts. The urban environment also provides numerous opportunities. One example being the better use of weather and environmental predictions to proactively optimize the functioning of the urban environment in terms of the use of energy, goods and services. Another is the providing of air quality forecasting services to benefit the health of the population. To address the challenges and opportunities facing megacities and large urban complexes, WMO has established the Global Atmosphere Watch (GAW) Urban Research Meteorology and Environment (GURME). Air pollution questions in urban areas, in particular megacities, is the main focus, building observational and modelling capabilities in developing countries through pilot projects and transfer of scientific expertise. GURME contributes to improving capabilities to handle meteorological and related features of air pollution by addressing end-to-end aspects of air quality, linking observational capabilities with the needs of chemical weather prediction, with the goal of providing high quality air quality services. Using examples from around the world but with specific reference to Africa, the unique challenges and opportunities related to megacities and large urban complexes, as perceived by the World Meteorological Organization (WMO) are highlighted.
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Challenges facing the marketing of scientific and research institutes
Directory of Open Access Journals (Sweden)
Bogdan Sojkin
2015-12-01
Full Text Available This article presents the challenges that scientific research institutions face in terms of their marketing, which have been divided into two groups of those associated with internal marketing and those linked to external marketing. The most significant and important determinants that constitute challenges to both internal and external marketing were described. The key aspects of each of the identified challenges were indicated, as was their impact on the implementation of the marketing policy at institutions.
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Karsai, Istvan; Kampis, George
2010-01-01
Biology is changing and becoming more quantitative. Research is creating new challenges that need to be addressed in education as well. New educational initiatives focus on combining laboratory procedures with mathematical skills, yet it seems that most curricula center on a single relationship between scientific knowledge and scientific method:…
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Applying evolutionary biology to address global challenges
Carroll, Scott P.; Jørgensen, Peter Søgaard; Kinnison, Michael T.; Bergstrom, Carl T.; Denison, R. Ford; Gluckman, Peter; Smith, Thomas B.; Strauss, Sharon Y.; Tabashnik, Bruce E.
2014-01-01
Two categories of evolutionary challenges result from escalating human impacts on the planet. The first arises from cancers, pathogens and pests that evolve too quickly, and the second from the inability of many valued species to adapt quickly enough. Applied evolutionary biology provides a suite of strategies to address these global challenges that threaten human health, food security, and biodiversity. This review highlights both progress and gaps in genetic, developmental and environmental manipulations across the life sciences that either target the rate and direction of evolution, or reduce the mismatch between organisms and human-altered environments. Increased development and application of these underused tools will be vital in meeting current and future targets for sustainable development. PMID:25213376
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Adequately Addressing Pediatric Obesity: Challenges Faced by Primary Care Providers.
Shreve, Marilou; Scott, Allison; Vowell Johnson, Kelly
2017-07-01
To assess the challenges primary care providers encounter when providing counseling for pediatric patients identified as obese. A survey assessed the current challenges and barriers to the screening and treatment of pediatric obesity for providers in northwest Arkansas who provide care to families. The survey consisted of 15 Likert scale questions and 4 open-ended questions. Time, resources, comfort, and cultural issues were reported by providers as the biggest barriers in screening and the treatment of pediatric obesity. All providers reported lack of time as a barrier to providing the care needed for obese children. Cultural barriers of both the provider and client were identified as factors, which negatively affect the care and treatment of obese children. Primary care providers continue to experience challenges when addressing pediatric obesity. In this study, a lack of adequate time to address obesity was identified as the most significant current barrier and may likely be tied to physician resources. Although reimbursement for obesity is increasing, the level of reimbursement does not support the time or the resources needed to treat patients. Many providers reported their patients' cultural view of obesity influenced how they counsel their patients. Increasing providers' knowledge concerning differences in how weight is viewed or valued may assist them in the assessment and care of obese pediatric patients. The challenges identified in previous research continue to limit providers when addressing obesity. Although progress has been made regarding knowledge of guidelines, continuing effort is needed to tackle the remaining challenges. This will allow for earlier identification and intervention, resulting in improved outcomes in pediatric obesity.
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Bayha, K. M.
2016-02-01
Plastics have revolutionized modern life, replacing other raw materials in a vast array of products, due to their ease in molding and shaping, as well as superior recalcitrance to wearing and aging. However, this functional benefit makes plastic one of the most problematic pollutants, since they accumulate as environmental debris for decades and possibly for centuries. Rightfully so, programs addressing plastic debris typically involve efforts to reduce consumption, reuse plastic products and recycle them when usefulness is complete. However, some of these options can be problematic for certain applications, as well as in countries that lack efficient municipal solid waste or recycling facilities. The principles of Green Chemistry were developed to help scientists design chemical products that reduce or eliminate the use or generation of hazardous substances. These principles have also been applied to developing sustainable or greener polymers for use in consumer plastics. For instance, the EPA's Green Chemistry Program awards the Presidential Green Chemistry Challenge Awards each year, with a large percentage of awards having gone to developments in greener polymers. Many of these advancements involve the development of sustainable bio-based, more degradable or more recyclable polymers that deliver significant environmental benefits. This presentation is meant to address what role the development of truly greener polymers might have in addressing environmental plastic debris in parallel with efforts to reduce, reuse and recycle. The intention is to evaluate the issues posed by traditional polymer types, address the ultimate goals of alternative polymer development and evaluate research on current alternative polymer technologies, in order to objectively assess their usefulness in addressing environmental plastic debris accumulation. In addition, the scientific, policy and market issues that may be impeding accurate development, evaluation and implementation of
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Jones, Jenny; Thomson, Patricia; Lauder, William; Leslie, Stephen J
2013-03-01
Reflexology is a complex massage intervention, based on the concept that specific areas of the feet (reflex points) correspond to individual internal organs within the body. Reflexologists trained in the popular Ingham reflexology method claim that massage to these points, using massage techniques unique to reflexology, stimulates an increase in blood supply to the corresponding organ. Reflexology researchers face two key methodological challenges that need to be addressed if a specific treatment-related hemodynamic effect is to be scientifically demonstrated. The first is the problem of inconsistent reflexology foot maps; the second is the issue of poor experimental controls. This article proposes a potential experimental solution that we believe can address both methodological challenges and in doing so, allow any specific hemodynamic treatment effect unique to reflexology to experimentally reveal itself.
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Do textbooks address known learning challenges in area measurement? A comparative analysis
Hong, Dae S.; Choi, Kyong Mi; Runnalls, Cristina; Hwang, Jihyun
2018-02-01
This study compared area lessons from Korean textbooks and US standard-based textbooks to understand differences and similarities among these textbooks, as well as how these textbooks address known learning challenges in area measurement. Several well-known challenges have been identified in previous studies, such as covering, array structure, and linking array structure to area formula. We were interested in knowing if textbooks addressed these issues in their treatments of area measurement and, in doing so, provided students with opportunities to overcome or become familiar with known challenges. The results show that both countries' textbooks demonstrated similar limitations; only few area and area-related lessons are covered and three important learning challenges in area measurement are not covered well, which need to be informed to practicing teachers.
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Scientific Challenges for a New X-ray Timing Mission
International Nuclear Information System (INIS)
Lamb, Frederick K.
2004-01-01
The Rossi X-ray Timing Explorer (RXTE) is an immensely successful mission of exploration and discovery. It has discovered a wealth of rapid X-ray variability phenomena that can be used to address fundamental questions concerning the properties of dense matter and strong gravitational fields as well as important astrophysical questions. It has answered many questions and is likely to answer many more, but to follow up fully on the major discoveries RXTE has made will require a new X-ray timing mission with greater capabilities. This introduction to the present volume describes briefly the advantages of X-ray timing measurements for determining the properties of dense matter and strong gravitational fields, indicates some of the key scientific questions that can be addressed using X-ray timing, and summarizes selected achievements of the RXTE mission. It concludes by citing some of the scientific capabilities a proposed follow-on mission will need in order to be successful
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International Nuclear Information System (INIS)
Khaleel, Mohammad A.
2009-01-01
This report is an account of the deliberations and conclusions of the workshop on 'Forefront Questions in Nuclear Science and the Role of High Performance Computing' held January 26-28, 2009, co-sponsored by the U.S. Department of Energy (DOE) Office of Nuclear Physics (ONP) and the DOE Office of Advanced Scientific Computing (ASCR). Representatives from the national and international nuclear physics communities, as well as from the high performance computing community, participated. The purpose of this workshop was to (1) identify forefront scientific challenges in nuclear physics and then determine which-if any-of these could be aided by high performance computing at the extreme scale; (2) establish how and why new high performance computing capabilities could address issues at the frontiers of nuclear science; (3) provide nuclear physicists the opportunity to influence the development of high performance computing; and (4) provide the nuclear physics community with plans for development of future high performance computing capability by DOE ASCR.
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Energy Technology Data Exchange (ETDEWEB)
Khaleel, Mohammad A.
2009-10-01
This report is an account of the deliberations and conclusions of the workshop on "Forefront Questions in Nuclear Science and the Role of High Performance Computing" held January 26-28, 2009, co-sponsored by the U.S. Department of Energy (DOE) Office of Nuclear Physics (ONP) and the DOE Office of Advanced Scientific Computing (ASCR). Representatives from the national and international nuclear physics communities, as well as from the high performance computing community, participated. The purpose of this workshop was to 1) identify forefront scientific challenges in nuclear physics and then determine which-if any-of these could be aided by high performance computing at the extreme scale; 2) establish how and why new high performance computing capabilities could address issues at the frontiers of nuclear science; 3) provide nuclear physicists the opportunity to influence the development of high performance computing; and 4) provide the nuclear physics community with plans for development of future high performance computing capability by DOE ASCR.
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Scientific and academic journals in the Philippines: status and challenges
Directory of Open Access Journals (Sweden)
Evelyn Mae Tecson-Mendoza
2015-08-01
Full Text Available As of July 2015, 28 Philippine scientific journals out of 777 Philippine scholarly journals are listed in the master journal lists of Thomson Reuters (TR, Scopus, or both. Of these scientific journals, thirteen are published by universities, two by government institutions, ten by professional organizations and three by private for-profit or non-profit organizations. Nineteen of these journals are over 25 years old, with the Philippine Journal of Science and the Philippine Agricultural Scientist being the oldest at 108 and 103 years in publication, respectively. Scientific journals in the Philippines, like other countries in Asia, face various increasing challenges. Among these challenges are getting listed in the master journal lists and citation databases of TR, Scopus, or both; obtaining funding; reaching a wider readership; attaining higher impact factors; competing for papers; and increased submission of manuscripts from outside the country. To promote the improvement of local journals, the National Academy of Science and Technology Philippines has given outstanding publication awards for scientific papers published in local journals for the past two decades. The Philippine Commission on Higher Education has accredited local journals that are included in either TR and Scopus journal master lists, and provides monetary incentives to accredited journals. Training workshops on scientific article writing and editorial management are conducted for researchers and editors by universities and professional and government organizations. A network of Philippine science editors has been formed to work together to upgrade and modernize selected journals to international standards.
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Scientific and computational challenges of the fusion simulation project (FSP)
International Nuclear Information System (INIS)
Tang, W M
2008-01-01
This paper highlights the scientific and computational challenges facing the Fusion Simulation Project (FSP). The primary objective is to develop advanced software designed to use leadership-class computers for carrying out multiscale physics simulations to provide information vital to delivering a realistic integrated fusion simulation model with unprecedented physics fidelity. This multiphysics capability will be unprecedented in that in the current FES applications domain, the largest-scale codes are used to carry out first-principles simulations of mostly individual phenomena in realistic 3D geometry while the integrated models are much smaller-scale, lower-dimensionality codes with significant empirical elements used for modeling and designing experiments. The FSP is expected to be the most up-to-date embodiment of the theoretical and experimental understanding of magnetically confined thermonuclear plasmas and to provide a living framework for the simulation of such plasmas as the associated physics understanding continues to advance over the next several decades. Substantive progress on answering the outstanding scientific questions in the field will drive the FSP toward its ultimate goal of developing a reliable ability to predict the behavior of plasma discharges in toroidal magnetic fusion devices on all relevant time and space scales. From a computational perspective, the fusion energy science application goal to produce high-fidelity, whole-device modeling capabilities will demand computing resources in the petascale range and beyond, together with the associated multicore algorithmic formulation needed to address burning plasma issues relevant to ITER - a multibillion dollar collaborative device involving seven international partners representing over half the world's population. Even more powerful exascale platforms will be needed to meet the future challenges of designing a demonstration fusion reactor (DEMO). Analogous to other major applied physics
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Biological approaches for addressing the grand challenge of providing access to clean drinking water
2011-01-01
The U.S. National Academy of Engineering (NAE) recently published a document presenting "Grand Challenges for Engineering". This list was proposed by leading engineers and scientists from around the world at the request of the U.S. National Science Foundation (NSF). Fourteen topics were selected for these grand challenges, and at least seven can be addressed using the tools and methods of biological engineering. Here we describe how biological engineers can address the challenge of providing access to clean drinking water. This issue must be addressed in part by removing or inactivating microbial and chemical contaminants in order to properly deliver water safe for human consumption. Despite many advances in technologies this challenge is expanding due to increased pressure on fresh water supplies and to new opportunities for growth of potentially pathogenic organisms. PMID:21453515
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W.E.B. DuBois's Challenge to Scientific Racism.
Taylor, Carol M.
1981-01-01
Proposes that a direct and authoritative challenge to the scientific racism of the late eighteenth and early twentieth centuries was urgently needed, and was one of the leading rhetorical contributions of W.E.B. DuBois. Specifically examines three issues: social Darwinism, the eugenics movement, and psychologists' measurement of intelligence.…
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Fredlund, T.; Linder, C.; Airey, J.
2015-09-01
In this article we characterize transient learning challenges as learning challenges that arise out of teaching situations rather than conflicts with prior knowledge. We propose that these learning challenges can be identified by paying careful attention to the representations that students produce. Once a transient learning challenge has been identified, teachers can create interventions to address it. By illustration, we argue that an appropriate way to design such interventions is to create variation around the disciplinary-relevant aspects associated with the transient learning challenge.
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Scientific challenges in the field of invasive alien plant management
CSIR Research Space (South Africa)
Van Wilgen, BW
2004-01-01
Full Text Available This article examines scientific challenges in the field of invasion alien plant management in South Africa. Overview of the Working for Water program, Issues of research funding, and Biological control research. It also includes some of the papers...
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nanoHUB.org: Experiences and Challenges in Software Sustainability for a Large Scientific Community
Directory of Open Access Journals (Sweden)
Lynn Zentner
2014-07-01
Full Text Available The science gateway nanoHUB.org, funded by the National Science Foundation (NSF, serves a large scientific community dedicated to research and education in nanotechnology with community-contributed simulation codes as well as a vast repository of other materials such as recorded presentations, teaching materials, and workshops and courses. Nearly 330,000 users annually access over 4400 items of content on nanoHUB, including 343 simulation tools. Arguably the largest nanotechnology facility in the world, nanoHUB has led the way not only in providing open access to scientific code in the nanotechnology community, but also in lowering barriers to the use of that code, by providing a platform where developers are able to easily and quickly deploy code written in a variety of languages with user-friendly graphical user interfaces and where users can run the latest versions of codes transparently on the grid or other powerful resources without ever having to download or update code. Being a leader in open access code deployment provides nanoHUB with opportunities and challenges as it meets the current and future needs of its community. This paper discusses the experiences of nanoHUB in addressing and adapting to the changing landscape of scientific software in ways that best serve its community and meet the needs of the largest portion of its user base.
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HIV/AIDS vaccines for Africa: scientific opportunities, challenges and strategies
Chin'ombe, Nyasha; Ruhanya, Vurayai
2015-01-01
More than decades have already elapsed since human immunodeficiency virus (HIV) was identified as the causative agent of acquired immunodeficiency syndrome (AIDS). The HIV has since spread to all parts of the world with devastating effects. In sub-saharan Africa, the HIV/AIDS epidemic has reached unprecedented proportions. Safe, effective and affordable HIV/AIDS vaccines for Africans are therefore urgently needed to contain this public health problem. Although, there are challenges, there are also scientific opportunities and strategies that can be exploited in the development of HIV/AIDS vaccines for Africa. The recent RV144 Phase III trial in Thailand has demonstrated that it is possible to develop a vaccine that can potentially elicit modest protective immunity against HIV infection. The main objective of this review is to outline the key scientific opportunities, challenges and strategies in HIV/AIDS vaccine development in Africa. PMID:26185576
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An assessment of open source promotion in addressing ICT acceptance challenges in Tanzania
CSIR Research Space (South Africa)
Kinyondo, J
2012-05-01
Full Text Available challenges. This study is an assessment of such OS promotion efforts in addressing ICT acceptance challenges in Tanzania specifically. The research design includes case studies done on four OS communities using document analysis, a questionnaire, interviews...
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Key scientific challenges in geological disposal of high level radioactive waste
International Nuclear Information System (INIS)
Wang Ju
2007-01-01
The geological disposal of high radioactive waste is a challenging task facing the scientific and technical world. This paper introduces the latest progress of high level radioactive disposal programs in the latest progress of high level radioactive disposal programs in the world, and discusses the following key scientific challenges: (1) precise prediction of the evolution of a repository site; (2) characteristics of deep geological environment; (3) behaviour of deep rock mass, groundwater and engineering material under coupled con-ditions (intermediate to high temperature, geostress, hydraulic, chemical, biological and radiation process, etc); (4) geo-chemical behaviour of transuranic radionuclides with low concentration and its migration with groundwater; and (5) safety assessment of disposal system. Several large-scale research projects and several hot topics related with high-level waste disposal are also introduced. (authors)
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Addressing informatics challenges in Translational Research with workflow technology.
Beaulah, Simon A; Correll, Mick A; Munro, Robin E J; Sheldon, Jonathan G
2008-09-01
Interest in Translational Research has been growing rapidly in recent years. In this collision of different data, technologies and cultures lie tremendous opportunities for the advancement of science and business for organisations that are able to integrate, analyse and deliver this information effectively to users. Workflow-based integration and analysis systems are becoming recognised as a fast and flexible way to build applications that are tailored to scientific areas, yet are built on a common platform. Workflow systems are allowing organisations to meet the key informatics challenges in Translational Research and improve disease understanding and patient care.
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The influence of future-oriented technology analysis: addressing the Cassandra challenge
JOHNSTON Ron; CAGNIN Cristiano
2011-01-01
This paper is based on a series of interviews with nine leading researchers conducted during the Future-Oriented Technology Analysis International Conference held in Seville on 16–17 October 2008. Analysis of these interviews paints a picture of FTA as an increasingly important approach being adopted in many countries to address the many challenges which are emerging at this time in human history. From this are drawn implications for the community of FTA practitioners. The biggest challenge i...
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Addressing the Challenge of Molecular Change: An Interim Report
Levine, Raphael D.
2018-04-01
Invited by the editorial committee of the Annual Review of Physical Chemistry to "contribute my autobiography," I present it here, as I understand the term. It is about my parents, my mentors, my coworkers, and my friends in learning and the scientific problems that we tried to address. Courtesy of the editorial assistance of Annual Reviews, some of the science is in the figure captions and sidebars. I am by no means done: I am currently trying to fuse the quantitative rigor of physical chemistry with systems biology while also dealing with a post-Born-Oppenheimer regime in electronic dynamics and am attempting to instruct molecules to perform advanced logic.
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Strategies to Address Common Challenges When Teaching in an Active Learning Classroom
Petersen, Christina I.; Gorman, Kristen S.
2014-01-01
This chapter provides practical strategies for addressing common challenges that arise for teachers in active learning classrooms. Our strategies come from instructors with experience teaching in these environments.
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Steck, R; Epari, D R; Schuetz, M A
2010-07-01
The collaboration of clinicians with basic science researchers is crucial for addressing clinically relevant research questions. In order to initiate such mutually beneficial relationships, we propose a model where early career clinicians spend a designated time embedded in established basic science research groups, in order to pursue a postgraduate qualification. During this time, clinicians become integral members of the research team, fostering long term relationships and opening up opportunities for continuing collaboration. However, for these collaborations to be successful there are pitfalls to be avoided. Limited time and funding can lead to attempts to answer clinical challenges with highly complex research projects characterised by a large number of "clinical" factors being introduced in the hope that the research outcomes will be more clinically relevant. As a result, the complexity of such studies and variability of its outcomes may lead to difficulties in drawing scientifically justified and clinically useful conclusions. Consequently, we stress that it is the basic science researcher and the clinician's obligation to be mindful of the limitations and challenges of such multi-factorial research projects. A systematic step-by-step approach to address clinical research questions with limited, but highly targeted and well defined research projects provides the solid foundation which may lead to the development of a longer term research program for addressing more challenging clinical problems. Ultimately, we believe that it is such models, encouraging the vital collaboration between clinicians and researchers for the work on targeted, well defined research projects, which will result in answers to the important clinical challenges of today. Copyright (c) 2010 Elsevier Ltd. All rights reserved.
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National Institutes of Health addresses the science of diversity
Valantine, Hannah A.; Collins, Francis S.
2015-01-01
The US biomedical research workforce does not currently mirror the nation’s population demographically, despite numerous attempts to increase diversity. This imbalance is limiting the promise of our biomedical enterprise for building knowledge and improving the nation’s health. Beyond ensuring fairness in scientific workforce representation, recruiting and retaining a diverse set of minds and approaches is vital to harnessing the complete intellectual capital of the nation. The complexity inherent in diversifying the research workforce underscores the need for a rigorous scientific approach, consistent with the ways we address the challenges of science discovery and translation to human health. Herein, we identify four cross-cutting diversity challenges ripe for scientific exploration and opportunity: research evidence for diversity’s impact on the quality and outputs of science; evidence-based approaches to recruitment and training; individual and institutional barriers to workforce diversity; and a national strategy for eliminating barriers to career transition, with scientifically based approaches for scaling and dissemination. Evidence-based data for each of these challenges should provide an integrated, stepwise approach to programs that enhance diversity rapidly within the biomedical research workforce. PMID:26392553
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Addressing the challenges in using qualitative data in qualitative comparative analysis
de Block, Debora; Vis, B.
2017-01-01
This paper addresses an issue that so far has received relatively little attention in methodological discussions about Qualitative Comparative Analysis (QCA), namely the challenges researchers face when using qualitative data in QCA analyses. Building on a literature review of 22 empirical studies
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Addressing the challenges of patient-centred design
Directory of Open Access Journals (Sweden)
Karen LaBat
2009-11-01
Full Text Available Patient-centred design is a relatively new term, but a longstanding concept in clinical practice. This discussion looks at patient-centred design and explores the relationships of patient-centred design to universal design, user-centred design and the newer human-centred design. It also explores why interdisciplinary approaches are needed for patient-centred design and how interdisciplinary collaboration works to address the challenges of patient centred design. Successful patient-centred solutions can grow from collaborations which include shared visions, understanding of both the nature and degree of variation in the patient,materials, and the designed solution, clear regular communication among all parties with careful definition of terms, and respect for the inherent cultures of all disciplines involved.
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Directory of Open Access Journals (Sweden)
Kabanova Natalia N.
2016-01-01
Full Text Available It has recently been shown that a person, an author particularly, faces the challenges of visualization in the cognitive process. The aim of this study is to consider the forms of thinking process and the changes happened in education process and in scientific activity. It was noted that the challenges connected with information perceiving during the work with the text occur in the process of creating academic papers as well. We conclude that the topical field of visualization covers not only the educative process assuming information transfer from person to person (model “teacher-student”, but the process of scientific activity. Applying the methods of visualization in publication activity is the factor for effective communication in social and cultural space that provides the opportunity for academic society to recognize results. We offer possible ways to promote scientific papers via online resources such as scientific social networks and tools of media corporations. The scientific social network ResearchGate and Thomson Reuters media corporation product as an online tool “Researcher ID” placed at the bibliographic database Web of Science TM Core Collection are used as the examples. We state that information technology allows authors to promote the results of their studies around the world.
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Energy Technology Data Exchange (ETDEWEB)
Khaleel, Mohammad A.; Johnson, Gary M.; Washington, Warren M.
2009-07-02
The U.S. Department of Energy (DOE) Office of Biological and Environmental Research (BER) in partnership with the Office of Advanced Scientific Computing Research (ASCR) held a workshop on the challenges in climate change science and the role of computing at the extreme scale, November 6-7, 2008, in Bethesda, Maryland. At the workshop, participants identified the scientific challenges facing the field of climate science and outlined the research directions of highest priority that should be pursued to meet these challenges. Representatives from the national and international climate change research community as well as representatives from the high-performance computing community attended the workshop. This group represented a broad mix of expertise. Of the 99 participants, 6 were from international institutions. Before the workshop, each of the four panels prepared a white paper, which provided the starting place for the workshop discussions. These four panels of workshop attendees devoted to their efforts the following themes: Model Development and Integrated Assessment; Algorithms and Computational Environment; Decadal Predictability and Prediction; Data, Visualization, and Computing Productivity. The recommendations of the panels are summarized in the body of this report.
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Numerical simulation of turbulent combustion: Scientific challenges
Ren, ZhuYin; Lu, Zhen; Hou, LingYun; Lu, LiuYan
2014-08-01
Predictive simulation of engine combustion is key to understanding the underlying complicated physicochemical processes, improving engine performance, and reducing pollutant emissions. Critical issues as turbulence modeling, turbulence-chemistry interaction, and accommodation of detailed chemical kinetics in complex flows remain challenging and essential for high-fidelity combustion simulation. This paper reviews the current status of the state-of-the-art large eddy simulation (LES)/prob-ability density function (PDF)/detailed chemistry approach that can address the three challenging modelling issues. PDF as a subgrid model for LES is formulated and the hybrid mesh-particle method for LES/PDF simulations is described. Then the development need in micro-mixing models for the PDF simulations of turbulent premixed combustion is identified. Finally the different acceleration methods for detailed chemistry are reviewed and a combined strategy is proposed for further development.
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MO-FG-BRB-01: Investing to Address the Global Cancer Challenge
International Nuclear Information System (INIS)
Atun, R.
2015-01-01
corresponding potential benefits of addressing this challenge. To describe what radiation therapy infrastructure, in terms of facilities, equipment and personnel, will be required to address this challenge. To describe models of addressing personnel and infrastructure mobilization and capacity building within regions where significant cancer treatment disparities exist
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MO-FG-BRB-01: Investing to Address the Global Cancer Challenge
Energy Technology Data Exchange (ETDEWEB)
Atun, R. [Harvard University (United States)
2015-06-15
corresponding potential benefits of addressing this challenge. To describe what radiation therapy infrastructure, in terms of facilities, equipment and personnel, will be required to address this challenge. To describe models of addressing personnel and infrastructure mobilization and capacity building within regions where significant cancer treatment disparities exist.
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Energy-Intensive Processes Portfolio: Addressing Key Energy Challenges Across U.S. Industry
Energy Technology Data Exchange (ETDEWEB)
None
2011-03-07
AMO is developing advanced technologies that cut energy use and carbon emissions in some of the most energy-intensive processes within U.S. manufacturing. The brochure describes the AMO R&D projects that address these challenges.
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Exploring social recommenders for teacher networks to address challenges of starting teachers
Fazeli, Soude; Drachsler, Hendrik; Brouns, Francis; Sloep, Peter
2012-01-01
Fazeli, S., Drachsler, H., Brouns, F., & Sloep, P. B. (2012, 4 April). Exploring social recommenders for teacher networks to address challenges of starting teachers. Presentation at the Eighth International Conference on Networked Learning 2012, Maastricht, The Netherlands.
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Tropospheric ozone and aerosols in climate agreements: scientific and political challenges
International Nuclear Information System (INIS)
Rypdal, Kristin; Berntsen, Terje; Fuglestvedt, Jan S.; Aunan, Kristin; Torvanger, Asbjorn; Stordal, Frode; Pacyna, Jozef M.; Nygaard, Lynn P.
2005-01-01
In addition to the six greenhouse gases included in the Kyoto Protocol, the tropospheric ozone precursors CO, NMVOC and NO x and the aerosols/aerosol precursors black carbon, organic carbon and SO 2 also play significant roles in climate change. The aim of this paper is to review some of the main scientific and political challenges associated with incorporating tropospheric ozone and aerosol precursors into climate agreements, and to discuss how these challenges have a bearing on the design of future climate agreements. We argue that the optimal policy design for a particular substance depends on a combination of scientific and political concerns. We look particularly at regional climate effects, negative forcing, metrics (measuring climate effects against other gases on a common scale), political attractiveness, and verification and compliance. We systematically review the existing knowledge on these issues, explore their impact on policy design, and conclude that, with current scientific knowledge, CO and NMVOC could conceivably be included in a global climate agreement, either in a basket with the long-lived greenhouse gases or in a separate basket, while NO x and aerosols might be regulated more appropriately through regional agreements with links to a global agreement. However, the complexity and fairness implications of including tropospheric ozone precursors and aerosols might negatively affect the political feasibility of a future agreement
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Addressing the Big-Earth-Data Variety Challenge with the Hierarchical Triangular Mesh
Rilee, Michael L.; Kuo, Kwo-Sen; Clune, Thomas; Oloso, Amidu; Brown, Paul G.; Yu, Honfeng
2016-01-01
We have implemented an updated Hierarchical Triangular Mesh (HTM) as the basis for a unified data model and an indexing scheme for geoscience data to address the variety challenge of Big Earth Data. We observe that, in the absence of variety, the volume challenge of Big Data is relatively easily addressable with parallel processing. The more important challenge in achieving optimal value with a Big Data solution for Earth Science (ES) data analysis, however, is being able to achieve good scalability with variety. With HTM unifying at least the three popular data models, i.e. Grid, Swath, and Point, used by current ES data products, data preparation time for integrative analysis of diverse datasets can be drastically reduced and better variety scaling can be achieved. In addition, since HTM is also an indexing scheme, when it is used to index all ES datasets, data placement alignment (or co-location) on the shared nothing architecture, which most Big Data systems are based on, is guaranteed and better performance is ensured. Moreover, our updated HTM encoding turns most geospatial set operations into integer interval operations, gaining further performance advantages.
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Liu, Gi-Zen; Chiu, Wan-Yu; Lin, Chih-Chung; Barrett, Neil E.
2014-12-01
To date, the concept of English for Specific Purposes has brought about a great impact on English language learning across various disciplines, including those in science education. Hence, this review paper aimed to address current English language learning in the science disciplines through the practice of computer-assisted language learning to identify the use of learning technologies in science-based literacy. In the literature review, the researchers found that science-based literacy instruction shares many pedagogical aims with English language teaching in terms of reading, writing, listening and speaking, allowing it to be classified as English for Scientific Purposes (EScP). To answer the research questions, the researchers conducted the survey by extracting related articles and teaching examples from the Web of Science. In the search procedure, the researchers used the keywords science OR scientific AND technolog* OR comput* in ten selected journals of social science citation index. Only articles which are specified as journal articles rather than other document types were included. After compiling the corpora, the researchers compared the trends, methodologies and results of EScP instruction in science education. The implications of this study include the opportunities, advantages and challenges for EScP instruction in science education to further develop better educational approaches, adopt new technologies, as well as offer some directions for researchers to conduct future studies.
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[The treatment of scientific knowledge in the framework of CITES].
Lanfranchi, Marie-Pierre
2014-03-01
Access to scientific knowledge in the context of CITES is a crucial issue. The effectiveness of the text is indeed largely based on adequate scientific knowledge of CITES species. This is a major challenge: more than 30,000 species and 178 member states are involved. The issue of expertise, however, is not really addressed by the Convention. The question was left to the consideration of the COP. Therefore, the COP has created two ad hoc scientific committees: the Plants Committee and the Animals Committee, conferring upon them an ambitious mandate. The article addresses some important issues at stake which are linked to institutional questions, as well as the mixed record after twenty-five years of practice.
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Addressing the Analytic Challenges of Cross-Sectional Pediatric Pneumonia Etiology Data.
Hammitt, Laura L; Feikin, Daniel R; Scott, J Anthony G; Zeger, Scott L; Murdoch, David R; O'Brien, Katherine L; Deloria Knoll, Maria
2017-06-15
Despite tremendous advances in diagnostic laboratory technology, identifying the pathogen(s) causing pneumonia remains challenging because the infected lung tissue cannot usually be sampled for testing. Consequently, to obtain information about pneumonia etiology, clinicians and researchers test specimens distant to the site of infection. These tests may lack sensitivity (eg, blood culture, which is only positive in a small proportion of children with pneumonia) and/or specificity (eg, detection of pathogens in upper respiratory tract specimens, which may indicate asymptomatic carriage or a less severe syndrome, such as upper respiratory infection). While highly sensitive nucleic acid detection methods and testing of multiple specimens improve sensitivity, multiple pathogens are often detected and this adds complexity to the interpretation as the etiologic significance of results may be unclear (ie, the pneumonia may be caused by none, one, some, or all of the pathogens detected). Some of these challenges can be addressed by adjusting positivity rates to account for poor sensitivity or incorporating test results from controls without pneumonia to account for poor specificity. However, no classical analytic methods can account for measurement error (ie, sensitivity and specificity) for multiple specimen types and integrate the results of measurements for multiple pathogens to produce an accurate understanding of etiology. We describe the major analytic challenges in determining pneumonia etiology and review how the common analytical approaches (eg, descriptive, case-control, attributable fraction, latent class analysis) address some but not all challenges. We demonstrate how these limitations necessitate a new, integrated analytical approach to pneumonia etiology data. © The Author 2017. Published by Oxford University Press for the Infectious Diseases Society of America.
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Exploring social recommenders for teacher networks to address challenges of starting teachers
Fazeli, Soude; Brouns, Francis; Drachsler, Hendrik; Sloep, Peter
2012-01-01
Fazeli, S., Brouns, F., Drachsler, H., & Sloep, P. B. (2012). Exploring social recommenders for teacher networks to address challenges of starting teachers. In V. Hodgson, C. Jones, M. de Laat, D. McConnell, T. Ryberg, & P. Sloep (Eds.), Proceedings of the Eighth International Conference on
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MO-FG-BRB-03: Addressing the Cancer Challenge: International Cancer Experts Corps
Energy Technology Data Exchange (ETDEWEB)
Coleman, N. [Center for Cancer Research, National Cancer Institute (United States)
2015-06-15
corresponding potential benefits of addressing this challenge. To describe what radiation therapy infrastructure, in terms of facilities, equipment and personnel, will be required to address this challenge. To describe models of addressing personnel and infrastructure mobilization and capacity building within regions where significant cancer treatment disparities exist.
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MO-FG-BRB-03: Addressing the Cancer Challenge: International Cancer Experts Corps
International Nuclear Information System (INIS)
Coleman, N.
2015-01-01
corresponding potential benefits of addressing this challenge. To describe what radiation therapy infrastructure, in terms of facilities, equipment and personnel, will be required to address this challenge. To describe models of addressing personnel and infrastructure mobilization and capacity building within regions where significant cancer treatment disparities exist
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Cocco, Massimo; Freda, Carmela; Haslinger, Florian; Consortium, Epos
2016-04-01
Addressing Ethics issues is nowadays a relevant challenge for any initiative, program or project dealing with scientific data and products provision, access to services for scientific purposes and communication with different stakeholders, including society. This is corroborated by the evidence that Ethics has very high priority in EU funded research. Indeed, all the activities carried out under Horizon 2020 must comply with ethical principles and national, Union and international legislation. This implies that "For all activities funded by the European Union, Ethics is an integral part of research from beginning to end, and ethical compliance is seen as pivotal to achieve real research excellence." Here, we present the experience of EPOS, a public pan-European research infrastructure. EPOS aims at integrating data, data products, services and software (DDSS) for solid Earth science generated and provided by monitoring networks, observing systems and facilities belonging to European countries. EPOS fosters the integrated use of multidisciplinary solid Earth data to improve the understanding of physical and chemical processes controlling earthquakes, volcanic eruptions, tsunamis as well as those driving tectonics and surface dynamics. The EPOS integration plan will make significant contributions to understanding and mitigating geo-hazards, yielding data for hazard assessment, data products for engaging different stakeholders, and services for training, education and communication to society. Numerous national research infrastructures engaged in EPOS are deployed for the monitoring of areas prone to geo-hazards and for the surveillance of the national territory including areas used for exploiting geo-resources. The EPOS community is therefore already trained to provide services to public (civil defence agencies, local and national authorities) and private (petroleum industry, mining industry, geothermal companies, aviation security) stakeholders. Our ability to
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Progression in Ethical Reasoning When Addressing Socio-scientific Issues in Biotechnology
Berne, Birgitta
2014-11-01
This article reports on the outcomes of an intervention in a Swedish school in which the author, a teacher-researcher, sought to develop students' (14-15 years old) ethical reasoning in science through the use of peer discussions about socio-scientific issues. Prior to the student discussions various prompts were used to highlight different aspects of the issues. In addition, students were given time to search for further information themselves. Analysis of students' written arguments, from the beginning of the intervention and afterwards, suggests that many students seem to be moving away from their use of everyday language towards using scientific concepts in their arguments. In addition, they moved from considering cloning and 'designer babies' solely in terms of the present to considering them in terms of the future. Furthermore, the students started to approach the issues in additional ways using not only consequentialism but also the approaches of virtue ethics, and rights and duties. Students' progression in ethical reasoning could be related to the characteristics of the interactions in peer discussions as students who critically and constructively argued with each other's ideas, and challenged each other's claims, made progress in more aspects of ethical reasoning than students merely using cumulative talk. As such, the work provides valuable indications for the importance of introducing peer discussions and debates about SSIs in connection to biotechnology into the teaching of science in schools.
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The NRPB future scientific programme (2002-2007)
International Nuclear Information System (INIS)
2002-01-01
This paper provides a detailed summary of the work planned for the lifetime of the Corporate Plan (2002-2007). Some of the work relates to new technologies, other work arises from challenges to accepted standards or because of new information from research. The Scientific Programme is set in the context of NRPB effort in the international arena to develop and address radiation issues and standards. This work pervades and influences aspects of the work programme in all of the scientific areas. The globally recognised expertise of NRPB can influence developments to ensure UK concerns are addressed and the UK research programmes meshes with international and collaborative research. The Scientific Programme is in line with the role of NRPB, our stated methods of working and the priorities identified by the 1999-2000 Strategic Review, Government Departments, Devolved Administrations and Agencies and the views of Board members. The future Scientific Programme spans the three principal functions of advice, research and the provision of technical services and draws on expertise from across the organisation. The Department of Health is responsible for ministerial approval of the Corporate Plan and Scientific Programme. (author)
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Balabanov, Pavel; Haas, Manuel; Elferink, Andre; Bakchine, Serge; Broich, Karl
2014-09-01
Improving and facilitating the process of making new drugs available to patients with multiple sclerosis (MS) requires cooperation among the regulators and other stakeholders. This cooperation will also positively contribute towards developing guidelines of the highest quality in medical, regulatory and scientific aspects. This would be beneficial both in areas that require further guideline development, but also in fields where existing guidance should be adapted to take into account evolution in science. Considering the input from all stakeholders, the European Medicines Agency confirmed its intention to update the relevant guideline and apply a flexible approach towards new drug development strategies in MS. This article is the first official position from the EU regulators, presenting the main changes to be expected in the guidance document. © The Author(s) 2014.
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Content addressable memories in scientific instruments
International Nuclear Information System (INIS)
Lotto, I. de; Golinelli, S.
1975-01-01
The content-addressable-memory feature of a new system designed in these laboratories for non-destructive testing of nuclear reactor pressure vessels based on acoustic emission analysis is presented. The content addressable memory is divided into two parts: the first selects the most frequent events among incoming ones (FES: Frequent Event Selection memory), the second stores the frequent events singled out (FEM: Frequent Event Memory). The statistical behaviour of FES is analyzed, and experimental results are compared with theoretical ones; the model presented proved to be a useful tool in dimensioning the instrument store capacity. (Auth.)
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Complex plasmas scientific challenges and technological opportunities
Lopez, Jose; Becker, Kurt; Thomsen, Hauke
2014-01-01
This book provides the reader with an introduction to the physics of complex plasmas, a discussion of the specific scientific and technical challenges they present, and an overview of their potential technological applications. Complex plasmas differ from conventional high-temperature plasmas in several ways: they may contain additional species, including nanometer- to micrometer-sized particles, negative ions, molecules and radicals, and they may exhibit strong correlations or quantum effects. This book introduces the classical and quantum mechanical approaches used to describe and simulate complex plasmas. It also covers some key experimental techniques used in the analysis of these plasmas, including calorimetric probe methods, IR absorption techniques and X-ray absorption spectroscopy. The final part of the book reviews the emerging applications of microcavity and microchannel plasmas, the synthesis and assembly of nanomaterials through plasma electrochemistry, the large-scale generation of ozone using mi...
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International Nuclear Information System (INIS)
Markovska, Natasa; Duić, Neven; Mathiesen, Brian Vad; Guzović, Zvonimir; Piacentino, Antonio; Schlör, Holger; Lund, Henrik
2016-01-01
Climate change and fossil fuel reserve depletion both pose challenges for energy security and for wellbeing in general. The top ten among them include: Decarbonising the world economy; Enhancing the energy efficiency and energy savings in buildings; Advancing the energy technologies; Moving towards energy systems based on variable renewables; Electrifying the transport and some industrial processes; Liberalizing and extending the energy markets; Integrating energy sectors to Smart Energy Systems; Making the cities and communities smart; Diversifying the energy sources; and Building more biorefineries. Presenting the contributions of selected conference papers published in the special issues of leading scientific journals (including all the papers from the current Energy special issue), this review demonstrates the capacity of the Conferences on Sustainable Development of Energy, Water and Environment Systems for generation of knowledge which could serve as the centrepiece of a pertinent response to those challenges. - Highlights: • Top ten challenges of energy security in the twenty-first century identified. • Selected SDEWES contributions analysed against the identified challenges. • The role of SDEWES as knowledge generator towards addressing the identified challenges credibly demonstrated.
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Dugas, Tammy R; Lomnicki, Slawomir; Cormier, Stephania A; Dellinger, Barry; Reams, Margaret
2016-06-08
Airborne fine and ultrafine particulate matter (PM) are often generated through widely-used thermal processes such as the combustion of fuels or the thermal decomposition of waste. Residents near Superfund sites are exposed to PM through the inhalation of windblown dust, ingestion of soil and sediments, and inhalation of emissions from the on-site thermal treatment of contaminated soils. Epidemiological evidence supports a link between exposure to airborne PM and an increased risk of cardiovascular and pulmonary diseases. It is well-known that during combustion processes, incomplete combustion can lead to the production of organic pollutants that can adsorb to the surface of PM. Recent studies have demonstrated that their interaction with metal centers can lead to the generation of a surface stabilized metal-radical complex capable of redox cycling to produce ROS. Moreover, these free radicals can persist in the environment, hence their designation as Environmentally Persistent Free Radicals (EPFR). EPFR has been demonstrated in both ambient air PM2.5 (diameter challenges associated with regulating this new, emerging contaminant.
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Addressing the human resource challenge in the electricity industry
Energy Technology Data Exchange (ETDEWEB)
NONE
2007-02-15
The electricity industry is facing significant challenges in terms of its labour forces in the years ahead due to an aging workforce and pending retirements in an industry already challenged by increasing demand, technological change and regulatory instability. A shortage of skilled labour could compromise the electricity sector in a variety of ways including: reduced reliability, increased cost of production, infrastructure projects delays, and decreased safety and productivity due to less experienced employees and worker shortages. This report presented a briefing of recommendations developed by the Canadian Electricity Association (CEA) that offered concrete solutions to addressing the electricity industry's workforce challenges. The recommendations focused around three areas: building Canadian skills base by investing in education, skills training and apprenticeships, particularly in underrepresented communities; ensuring trained, skilled workers are able to work and flourish in their area of expertise by streamlining certification and credential recognition, and facilitating workforce mobility; and attracting and retaining skilled foreign workers by ensuring successful community and workplace integration. Background information on the electricity industry in Canada was also presented. The CEA also proposed a list of policy initiatives to ensure the Canadian electricity industry can maintain and enhance its human and electricity potential. It was concluded that the CEA is prepared to develop detailed implementation plans and programs to operationalize any and all of the recommendations in the briefing. 2 figs.
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Scientific Opportunities to Reduce Risk in Nuclear Process Science
International Nuclear Information System (INIS)
Bredt, Paul R.; Felmy, Andrew R.; Gauglitz, Phillip A.; Poloski, Adam P.; Vienna, John D.; Moyer, Bruce A.; Hobbs, David; Wilmarth, B.; Mcilwain, Michael; Subramanian, K.; Krahn, Steve; Machara, N.
2009-01-01
Cleaning up the nation's nuclear weapons complex remains as one of the most technologically challenging and financially costly problems facing the U.S. Department of Energy (DOE). Safety, cost, and technological challenges have often delayed progress in retrieval, processing, and final disposition of high-level waste, spent nuclear fuel, and challenging materials. Some of the issues result from the difficulty and complexity of the technological issues; others have programmatic bases, such as strategies that may provide undue focus on near-term goals or difficulty in developing and maintaining stakeholder confidence in the proposed solutions. We propose that independent basic fundamental science research, addressing the full cleanup life-cycle, offers an opportunity to help address these challenges by providing (1) scientific insight into the fundamental mechanisms involved in currently selected processing and disposal options, (2) a rational path to the development of alternative technologies should the primary options fail, (3) confidence that models that predict long-term performance of different disposal options are based upon the best available science, and (4) fundamental science discovery that enables transformational solutions to revolutionize the current baseline processes. Over the last 3 years, DOE's Office of Environmental Management (EM) has experienced a fundamental shift in philosophy. The mission focus of driving to closure has been replaced by one of enabling the long-term needs of DOE and the nation. Resolving new challenges, such as the disposition of DOE spent nuclear fuel, have been added to EM's responsibilities. In addition, the schedules for addressing several elements of the cleanup mission have been extended. As a result, EM's mission is no longer focused only on driving the current baselines to closure. Meeting the mission will require fundamental advances over at least a 30-year window if not longer as new challenges are added. The
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The importance of fungi and mycology for addressing major global challenges*
Lange, Lene
2014-01-01
In the new bioeconomy, fungi play a very important role in addressing major global challenges, being instrumental for improved resource efficiency, making renewable substitutes for products from fossil resources, upgrading waste streams to valuable food and feed ingredients, counteracting life-style diseases and antibiotic resistance through strengthening the gut biota, making crop plants more robust to survive climate change conditions, and functioning as host organisms for production of new...
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Zizzo, Natalie; Racine, Eric
2017-11-09
Fetal alcohol spectrum disorder (FASD) is a leading form of neurodevelopmental delay in Canada, affecting an estimated 3000 babies per year. FASD involves a range of disabilities that entail significant costs to affected individuals, families, and society. Exposure to alcohol in utero is a necessary factor for FASD development, and this has led to FASD being described as "completely preventable". However, there are significant ethical challenges associated with FASD prevention. These challenges revolve around 1) what should be communicated about the risks of alcohol consumption during pregnancy, given some ongoing scientific uncertainty about the effects of prenatal alcohol exposure, and 2) how to communicate these risks, given the potential for stigma against women who give birth to children with FASD as well as against children and adults with FASD. In this paper, we share initial thoughts on how primary care physicians can tackle this complex challenge. First, we recommend honest disclosure of scientific evidence to women and the tailoring of information offered to pregnant women. Second, we propose a contextualized, patient-centred, compassionate approach to ensure that appropriate advice is given to patients in a supportive, non-stigmatizing way.
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Symposium on international safeguards: Addressing verification challenges. Book of extended synopses
International Nuclear Information System (INIS)
2006-01-01
A safeguards symposium has traditionally been organized by the Safeguards Department approximately every four years. The 2006 symposium addresses challenges to IAEA safeguards that have emerged or grown more serious since 2001. The increase in size and flexibility of uranium enrichment plants, for instance, and the spread of enrichment technology to a wider circle of States, pose challenges to traditional safeguards approaches. The procurement and supply networks discovered in 2004, dealing in sensitive nuclear technology and information, have serious implications for the future effectiveness of IAEA safeguards. The symposium will provide an opportunity for the IAEA and Member States to discuss options for dealing constructively with trade in sensitive nuclear technology. Reflecting developments since 2001, the 2006 symposium will focus on current challenges to the safeguards system, improving collection and analysis of safeguards information (analysis, processing tools, satellite imagery), advances in safeguards techniques and technology (future technology, neutron techniques, spent fuel verification, reprocessing, environmental sampling, containment and surveillance), further strengthening safeguards practices and approaches (safeguards approaches, integrated safeguards, R/SSAC, destructive analysis, non-destructive analysis, enrichment, reprocessing, spent fuel transfer) and future challenges. This publication contains 183 extended synopses, each of them was indexed separately
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Symposium on international safeguards: Addressing verification challenges. Book of extended synopses
Energy Technology Data Exchange (ETDEWEB)
NONE
2006-07-01
A safeguards symposium has traditionally been organized by the Safeguards Department approximately every four years. The 2006 symposium addresses challenges to IAEA safeguards that have emerged or grown more serious since 2001. The increase in size and flexibility of uranium enrichment plants, for instance, and the spread of enrichment technology to a wider circle of States, pose challenges to traditional safeguards approaches. The procurement and supply networks discovered in 2004, dealing in sensitive nuclear technology and information, have serious implications for the future effectiveness of IAEA safeguards. The symposium will provide an opportunity for the IAEA and Member States to discuss options for dealing constructively with trade in sensitive nuclear technology. Reflecting developments since 2001, the 2006 symposium will focus on current challenges to the safeguards system, improving collection and analysis of safeguards information (analysis, processing tools, satellite imagery), advances in safeguards techniques and technology (future technology, neutron techniques, spent fuel verification, reprocessing, environmental sampling, containment and surveillance), further strengthening safeguards practices and approaches (safeguards approaches, integrated safeguards, R/SSAC, destructive analysis, non-destructive analysis, enrichment, reprocessing, spent fuel transfer) and future challenges. This publication contains 183 extended synopses, each of them was indexed separately.
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Baraka, Jitihada; Rusibamayila, Asinath; Kalolella, Admirabilis; Baynes, Colin
2015-12-01
Provider perspectives have been overlooked in efforts to address the challenges of unmet need for family planning (FP). This qualitative study was undertaken in Tanzania, using 22 key informant interviews and 4 focus group discussions. The research documents perceptions of healthcare managers and providers in a rural district on the barriers to meeting latent demand for contraception. Social-ecological theory is used to interpret the findings, illustrating how service capability is determined by the social, structural and organizational environment. Providers' efforts to address unmet need for FP services are constrained by unstable reproductive preferences, low educational attainment, and misconceptions about contraceptive side effects. Societal and organizational factors--such as gender dynamics, economic conditions, religious and cultural norms, and supply chain bottlenecks, respectively--also contribute to an adverse environment for meeting needs for care. Challenges that healthcare providers face interact and produce an effect which hinders efforts to address unmet need. Interventions to address this are not sufficient unless the supply of services is combined with systems strengthening and social engagement strategies in a way that reflects the multi-layered, social institutional problems.
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The scientific study of inspiration in the creative process: Challenges and opportunities
Directory of Open Access Journals (Sweden)
Victoria C. Oleynick
2014-06-01
Full Text Available Inspiration is a motivational state that compels individuals to bring ideas into fruition. Creators have long argued that inspiration is important to the creative process, but until recently, scientists have not investigated this claim. In this article, we review challenges to the study of creative inspiration, as well as solutions to these challenges afforded by theoretical and empirical work on inspiration over the past decade. First, we discuss the problem of definitional ambiguity, which has been addressed through an integrative process of construct conceptualization. Second, we discuss the challenge of how to operationalize inspiration. This challenge has been overcome by the development and validation of the Inspiration Scale, which may be used to assess trait or state inspiration. Third, we address ambiguity regarding how inspiration differs from related concepts (creativity, insight, positive affect by discussing discriminant validity. Next, we discuss the preconception that inspiration is less important than perspiration (effort, and we review empirical evidence that inspiration and effort both play important—but different—roles in the creative process. Finally, with many challenges overcome, we argue that the foundation is now set for a new generation of research focused on neural underpinnings. We discuss potential challenges to and opportunities for the neuroscientific study of inspiration. A better understanding of the biological basis of inspiration will illuminate the process through which creative ideas fire the soul, such that individuals are compelled to transform ideas into products and solutions that may benefit society.
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Inclusion and exclusion in nutrigenetics clinical research: ethical and scientific challenges.
Hurlimann, T; Stenne, R; Menuz, V; Godard, B
2011-01-01
There are compelling reasons to ensure the participation of ethnic minorities and populations of all ages worldwide in nutrigenetics clinical research. If findings in such research are valid for some individuals, groups, or communities, and not for others, then ethical questions of justice--and not only issues of methodology and external validity--arise. This paper aims to examine inclusion in nutrigenetics clinical research and its scientific and ethical challenges. In total, 173 publications were identified through a systematic review of clinical studies in nutrigenetics published between 1998 and 2007. Data such as participants' demographics as well as eligibility criteria were extracted. There is no consistency in the way participants' origins (ancestry, ethnicity, or race) and ages are described in publications. A vast majority of the studies identified was conducted in North America and Europe and focused on 'white' participants. Our results show that pregnant women (and fetuses), minors, and the elderly (≥ 75 years old) remain underrepresented. Representativeness in nutrigenetics research is a challenging ethical and scientific issue. Yet, if nutrigenetics is to benefit whole populations and be used in public and global health agendas, fair representation as well as clear descriptions of participants in publications are crucial. Copyright © 2012 S. Karger AG, Basel.
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Center for Technology for Advanced Scientific Component Software (TASCS)
Energy Technology Data Exchange (ETDEWEB)
Damevski, Kostadin [Virginia State Univ., Petersburg, VA (United States)
2009-03-30
A resounding success of the Scientific Discover through Advanced Computing (SciDAC) program is that high-performance computational science is now universally recognized as a critical aspect of scientific discovery [71], complementing both theoretical and experimental research. As scientific communities prepare to exploit unprecedened computing capabilities of emerging leadership-class machines for multi-model simulations at the extreme scale [72], it is more important than ever to address the technical and social challenges of geographically distributed teams that combine expertise in domain science, applied mathematics, and computer science to build robust and flexible codes that can incorporate changes over time. The Center for Technology for Advanced Scientific Component Software (TASCS) tackles these issues by exploiting component-based software development to facilitate collaborative hig-performance scientific computing.
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Research initiatives for plug-and-play scientific computing
International Nuclear Information System (INIS)
McInnes, Lois Curfman; Dahlgren, Tamara; Nieplocha, Jarek; Bernholdt, David; Allan, Ben; Armstrong, Rob; Chavarria, Daniel; Elwasif, Wael; Gorton, Ian; Kenny, Joe; Krishan, Manoj; Malony, Allen; Norris, Boyana; Ray, Jaideep; Shende, Sameer
2007-01-01
This paper introduces three component technology initiatives within the SciDAC Center for Technology for Advanced Scientific Component Software (TASCS) that address ever-increasing productivity challenges in creating, managing, and applying simulation software to scientific discovery. By leveraging the Common Component Architecture (CCA), a new component standard for high-performance scientific computing, these initiatives tackle difficulties at different but related levels in the development of component-based scientific software: (1) deploying applications on massively parallel and heterogeneous architectures, (2) investigating new approaches to the runtime enforcement of behavioral semantics, and (3) developing tools to facilitate dynamic composition, substitution, and reconfiguration of component implementations and parameters, so that application scientists can explore tradeoffs among factors such as accuracy, reliability, and performance
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Nanotechnology: Scientific challenges and societal benefits and risks
Romig, A. D.
2004-12-01
The field of nanotechnology is developing rapidly, as are its practical application in society. In this article, we give examples that demonstrate the enormous potential that exists for this new class of materials, and for devices with critical dimensions of less than 100 nm. We also identify some of the challenges that need to be faced in order to fully realize the practical benefits of nanotechnology, and discuss possible risks that may come with this new technology. In all cases, the unique advantage of nanotechnology can be traced back to nanoscale physical and chemical properties that are quite different from those encountered in more traditional microscopic (micro) or macroscopic (macro) materials and devices. Unique nanoscale properties and behaviors are already being used to increase energy efficiency, improve healthcare, and strengthen national security. However, while progress is rapid, many challenges remain. These include manufacturing at the nanoscale, integration of nanoscale materials and devices with more conventional technology, and predictive modeling that will allow nanotechnology to be engineered reliably into useful applications and products. Nanotechnology can be expected to have an increasing impact on human lives and society at large. As we strive to use nanotechnology to improve human life through better healthcare, cleaner environment, and improved national security, we must also work to detect and assess the negative impacts that nanotechnology science (or any new technology) might bring. We suggest that the conduct of should be allowed to proceed unimpeded, so that we can fully understand and appreciate the rules of nature at the nanometer scale. That said, scientific pursuits that involve self-replication in synthetic systems, encryption, defense technology, or the enhancement of human intelligence should be reviewed. The development of new technology from fundamental science and the process of deciding what new technology is to be
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The importance of fungi and mycology for addressing major global challenges*.
Lange, Lene
2014-12-01
In the new bioeconomy, fungi play a very important role in addressing major global challenges, being instrumental for improved resource efficiency, making renewable substitutes for products from fossil resources, upgrading waste streams to valuable food and feed ingredients, counteracting life-style diseases and antibiotic resistance through strengthening the gut biota, making crop plants more robust to survive climate change conditions, and functioning as host organisms for production of new biological drugs. This range of new uses of fungi all stand on the shoulders of the efforts of mycologists over generations: the scientific discipline mycology has built comprehensive understanding within fungal biodiversity, classification, evolution, genetics, physiology, ecology, pathogenesis, and nutrition. Applied mycology could not make progress without this platform. To unfold the full potentials of what fungi can do for both environment and man we need to strengthen the field of mycology on a global scale. The current mission statement gives an overview of where we are, what needs to be done, what obstacles to overcome, and which potentials are within reach. It further provides a vision for how mycology can be strengthened: The time is right to make the world aware of the immense importance of fungi and mycology for sustainable global development, where land, water and biological materials are used in a more efficient and more sustainable manner. This is an opportunity for profiling mycology by narrating the role played by fungi in the bioeconomy. Greater awareness and appreciation of the role of fungi can be used to build support for mycology around the world. Support will attract more talent to our field of study, empower mycologists around the world to generate more funds for necessary basic research, and strengthen the global mycology network. The use of fungi for unlocking the full potentials of the bioeconomy relies on such progress. The fungal kingdom can be an
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Block, de Debora; Vis, Barbara
2018-01-01
The use of qualitative data has so far received relatively little attention in methodological discussions on qualitative comparative analysis (QCA). This article addresses this lacuna by discussing the challenges researchers face when transforming qualitative data into quantitative data in QCA. By
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Scientific Opportunities to Reduce Risk in Nuclear Process Science
International Nuclear Information System (INIS)
Bredt, P.R.; Felmy, A.R.; Gauglitz, P.A.; Poloski, A.P.; Vienna, J.D.; Moyer, B.A.; Hobbs, D.; Wilmarth, B.; McIlwain, M.; Subramanian, K.; Krahn, S.; Machara, N.
2009-01-01
Cleaning up the nation's nuclear weapons complex remains as one of the most technologically challenging and financially costly problems facing the U.S. Department of Energy (DOE). Safety, cost, and technological challenges have often delayed progress in retrieval, processing, and final disposition of high-level waste, spent nuclear fuel, and challenging materials. Some of the issues result from the difficulty and complexity of the technological issues; others have programmatic bases, such as strategies that may provide undue focus on near-term goals or difficulty in developing and maintaining stakeholder confidence in the proposed solutions. We propose that independent basic fundamental science research addressing the full cleanup life-cycle offers an opportunity to help address these challenges by providing 1) scientific insight into the fundamental mechanisms involved in currently selected processing and disposal options, 2) a rational path to the development of alternative technologies should the primary options fail, 3) confidence that models that predict long-term performance of different disposal options are based upon the best available science, and 4) fundamental science discovery that enables transformational solutions to revolutionize the current baseline processes. Over the last 3 years, DoE's Office of Environmental Management (EM) has experienced a fundamental shift in philosophy. The mission focus of driving to closure has been replaced by one of enabling the long-term needs of DOE and the nation. Resolving new challenges, such as the disposition of DOE spent nuclear fuel, have been added to EM's responsibilities. In addition, the schedules for addressing several elements of the cleanup mission have been extended. As a result, EM's mission is no longer focused only on driving the current baselines to closure. Meeting the mission will require fundamental advances over at least a 30-year window if not longer as new challenges are added. The overall
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Journal hijacking: A new challenge for medical scientific community
Directory of Open Access Journals (Sweden)
Jafar Kolahi
2015-01-01
Full Text Available Researchers and scientific communities have encountered a horrible event named journal hijacking. In this paper, we present the unethical and criminal practices of journal hijacking. A hijacked journal is a legitimate scientific journal that offers print-only version, for which a bogus website has been created by a malicious third party fake publisher for the purpose of fraudulently offering research scientists the chance to rapidly publish their paper online with publication fee. Journal hijackers are dominant in analyzing the behaviors of researchers and journalism worldwide. They find the email addresses of authors from the websites of commercial and non-peer-reviewed journals. During last few years, more than one hundred of hijacked journals have been observed unbelievably. Whoever they are, it is apparent that they have the knowledge required to design a website, manage an open access e-journal, and they are skilled to hide their characteristics on the World Wide Web. They are aware that many of authors are in urgent need to publish their work in well-known prestigious journals. The goal of an anti-journal hijacking strategy should be to disseminate knowledge about such scams and to train authors so they will have the basic skills required to avoid fake publishers and hijacked journals.
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Energy Technology Data Exchange (ETDEWEB)
Lucas, Robert [University of Southern California, Information Sciences Institute; Ang, James [Sandia National Laboratories; Bergman, Keren [Columbia University; Borkar, Shekhar [Intel; Carlson, William [Institute for Defense Analyses; Carrington, Laura [University of California, San Diego; Chiu, George [IBM; Colwell, Robert [DARPA; Dally, William [NVIDIA; Dongarra, Jack [University of Tennessee; Geist, Al [Oak Ridge National Laboratory; Haring, Rud [IBM; Hittinger, Jeffrey [Lawrence Livermore National Laboratory; Hoisie, Adolfy [Pacific Northwest National Laboratory; Klein, Dean Micron; Kogge, Peter [University of Notre Dame; Lethin, Richard [Reservoir Labs; Sarkar, Vivek [Rice University; Schreiber, Robert [Hewlett Packard; Shalf, John [Lawrence Berkeley National Laboratory; Sterling, Thomas [Indiana University; Stevens, Rick [Argonne National Laboratory; Bashor, Jon [Lawrence Berkeley National Laboratory; Brightwell, Ron [Sandia National Laboratories; Coteus, Paul [IBM; Debenedictus, Erik [Sandia National Laboratories; Hiller, Jon [Science and Technology Associates; Kim, K. H. [IBM; Langston, Harper [Reservoir Labs; Murphy, Richard Micron; Webster, Clayton [Oak Ridge National Laboratory; Wild, Stefan [Argonne National Laboratory; Grider, Gary [Los Alamos National Laboratory; Ross, Rob [Argonne National Laboratory; Leyffer, Sven [Argonne National Laboratory; Laros III, James [Sandia National Laboratories
2014-02-10
Exascale computing systems are essential for the scientific fields that will transform the 21st century global economy, including energy, biotechnology, nanotechnology, and materials science. Progress in these fields is predicated on the ability to perform advanced scientific and engineering simulations, and analyze the deluge of data. On July 29, 2013, ASCAC was charged by Patricia Dehmer, the Acting Director of the Office of Science, to assemble a subcommittee to provide advice on exascale computing. This subcommittee was directed to return a list of no more than ten technical approaches (hardware and software) that will enable the development of a system that achieves the Department's goals for exascale computing. Numerous reports over the past few years have documented the technical challenges and the non¬-viability of simply scaling existing computer designs to reach exascale. The technical challenges revolve around energy consumption, memory performance, resilience, extreme concurrency, and big data. Drawing from these reports and more recent experience, this ASCAC subcommittee has identified the top ten computing technology advancements that are critical to making a capable, economically viable, exascale system.
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Addressing water challenges on the North China Plain with hydroeconomic optimization
DEFF Research Database (Denmark)
Martinsen, Grith; Davidsen, Claus; Bauer-Gottwein, Peter
. This enables the representation of links and interactions between the water resources system and the power system of Northern China. The multi-reservoir LP model is formulated as a flow path based optimization, which tracks each water delivery from supplier to receiver. This is useful for the exploration...... constructed. However, the project alone cannot solve the NCP’s water crisis. A hydroeconomic optimization model has been developed for the NCP system. The model area represents the administrative area of the Hai River Commission. The challenges addressed are the spatio-temporal distribution of costs......With its diverse environment and large population, China is facing water resource challenges, both in terms of quantity and quality. The North China Plain (NCP) is one of the world’s most densely populated areas and one of the highly water stressed regions of China. It counts for 15% of the Chinese...
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Biological network extraction from scientific literature: state of the art and challenges.
Li, Chen; Liakata, Maria; Rebholz-Schuhmann, Dietrich
2014-09-01
Networks of molecular interactions explain complex biological processes, and all known information on molecular events is contained in a number of public repositories including the scientific literature. Metabolic and signalling pathways are often viewed separately, even though both types are composed of interactions involving proteins and other chemical entities. It is necessary to be able to combine data from all available resources to judge the functionality, complexity and completeness of any given network overall, but especially the full integration of relevant information from the scientific literature is still an ongoing and complex task. Currently, the text-mining research community is steadily moving towards processing the full body of the scientific literature by making use of rich linguistic features such as full text parsing, to extract biological interactions. The next step will be to combine these with information from scientific databases to support hypothesis generation for the discovery of new knowledge and the extension of biological networks. The generation of comprehensive networks requires technologies such as entity grounding, coordination resolution and co-reference resolution, which are not fully solved and are required to further improve the quality of results. Here, we analyse the state of the art for the extraction of network information from the scientific literature and the evaluation of extraction methods against reference corpora, discuss challenges involved and identify directions for future research. © The Author 2013. Published by Oxford University Press. For Permissions, please email: journals.permissions@oup.com.
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Elmusharaf, Khalifa; Byrne, Elaine; O'Donovan, Diarmuid
2015-09-08
Universal health access will not be achieved unless women are cared for in their own communities and are empowered to take decisions about their own health in a supportive environment. This will only be achieved by community-based demand side interventions for maternal health access. In this review article, we highlight three common strategies to increase demand-side barriers to maternal healthcare access and identify the main challenges that still need to be addressed for these strategies to be effective. Common demand side strategies can be grouped into three categories:(i) Financial incentives/subsidies; (ii) Enhancing patient transfer, and; (iii) Community involvement. The main challenges in assessing the effectiveness or efficacy of these interventions or strategies are the lack of quality evidence on their outcome and impact and interventions not integrated into existing health or community systems. However, what is highlighted in this review and overlooked in most of the published literature on this topic is the lack of knowledge about the context in which these strategies are to be implemented. We suggest three challenges that need to be addressed to create a supportive environment in which these demand-side strategies can effectively improve access to maternal health services. These include: addressing decision-making norms, engaging in intergenerational dialogue, and designing contextually appropriate communication strategies.
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Cultural dimensions of learning: Addressing the challenges of multicultural instruction
Directory of Open Access Journals (Sweden)
Patrick Parrish
2010-05-01
Full Text Available The growing multicultural nature of education and training environments makes it critical that instructors and instructional designers, especially those working in online learning environments, develop skills to deliver culturally sensitive and culturally adaptive instruction. This article explores research into cultural differences to identify those dimensions of culture that are most likely to impact instructional situations. It presents these in the cultural dimensions of learning framework (CDLF, which describes a set of eight cultural parameters regarding social relationships, epistemological beliefs, and temporal perceptions, and illustrates their spectrums of variability as they might be exhibited in instructional situations. The article also explores the literature on instructional design and culture for guidelines on addressing the cross-cultural challenges faced by instructional providers. It suggests that these challenges can be overcome through increased awareness, culturally sensitive communication, modified instructional design processes, and efforts to accommodate the most critical cultural differences. Finally, it describes the use of the CDLF questionnaire as a tool to illuminate the range of preferences existing among learners and to discover the potential range of strategies and tactics that might be useful for a given set of learners.
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2016-04-01
Acknowledgments Contact Acknowledgments Related GAO Products Page 75 GAO-16-378 DOD Overseas Absentee Voting U.S. Postal Service: Actions... Products Page 76 GAO-16-378 DOD Overseas Absentee Voting Election Reform: Nine States’ Experiences Implementing Federal Requirements for...ELECTIONS DOD Needs More Comprehensive Planning to Address Military and Overseas Absentee Voting Challenges
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Grand challenges for integrated USGS science—A workshop report
Jenni, Karen E.; Goldhaber, Martin B.; Betancourt, Julio L.; Baron, Jill S.; Bristol, R. Sky; Cantrill, Mary; Exter, Paul E.; Focazio, Michael J.; Haines, John W.; Hay, Lauren E.; Hsu, Leslie; Labson, Victor F.; Lafferty, Kevin D.; Ludwig, Kristin A.; Milly, Paul C. D.; Morelli, Toni L.; Morman, Suzette A.; Nassar, Nedal T.; Newman, Timothy R.; Ostroff, Andrea C.; Read, Jordan S.; Reed, Sasha C.; Shapiro, Carl D.; Smith, Richard A.; Sanford, Ward E.; Sohl, Terry L.; Stets, Edward G.; Terando, Adam J.; Tillitt, Donald E.; Tischler, Michael A.; Toccalino, Patricia L.; Wald, David J.; Waldrop, Mark P.; Wein, Anne; Weltzin, Jake F.; Zimmerman, Christian E.
2017-06-30
Executive SummaryThe U.S. Geological Survey (USGS) has a long history of advancing the traditional Earth science disciplines and identifying opportunities to integrate USGS science across disciplines to address complex societal problems. The USGS science strategy for 2007–2017 laid out key challenges in disciplinary and interdisciplinary arenas, culminating in a call for increased focus on a number of crosscutting science directions. Ten years on, to further the goal of integrated science and at the request of the Executive Leadership Team (ELT), a workshop with three dozen invited scientists spanning different disciplines and career stages in the Bureau convened on February 7–10, 2017, at the USGS John Wesley Powell Center for Analysis and Synthesis in Fort Collins, Colorado.The workshop focused on identifying “grand challenges” for integrated USGS science. Individual participants identified nearly 70 potential grand challenges before the workshop and through workshop discussions. After discussion, four overarching grand challenges emerged:Natural resource security,Societal risk from existing and emerging threats,Smart infrastructure development, andAnticipatory science for changing landscapes.Participants also identified a “comprehensive science challenge” that highlights the development of integrative science, data, models, and tools—all interacting in a modular framework—that can be used to address these and other future grand challenges:Earth Monitoring, Analyses, and Projections (EarthMAP)EarthMAP is our long-term vision for an integrated scientific framework that spans traditional scientific boundaries and disciplines, and integrates the full portfolio of USGS science: research, monitoring, assessment, analysis, and information delivery.The Department of Interior, and the Nation in general, have a vast array of information needs. The USGS meets these needs by having a broadly trained and agile scientific workforce. Encouraging and supporting
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International Nuclear Information System (INIS)
Ayoub, Rakan; Borovas, George; Burkart, Alex; Gorn, Janet; Cho, Carl; Duncan, Aleshia; ); Gadomski, Chris; Ha, Jaejoo; ); Keppler, Jan Horst; ); Kuchinov, Vladimir; Lipman, Dan; Mathieson, John; McGinnis, Ed; Murphy, Paul; Mussler, Robert; Paillere, Henri; ); Reilly, Fiona; Sadayasu, Motomitsu; Schapiro, Regine; Shropshire, David; ); Duncan, Aleshia; Kmiec, Weronika; Grosch, Gisela; Lundell, Charlotta; Pham Van, Andree; Vuillaume; Allen Hamilton, Booz; Barkatullah, Nadira; Rollat, Xavier
2016-01-01
In May 2016, the International Framework for Nuclear Energy Cooperation (IFNEC) held a conference in cooperation with the Nuclear Energy Agency (NEA) on 'Nuclear Energy's Role in the 21. Century: Addressing the Challenge of Financing'. This conference brought together over 150 stakeholders from more than 30 countries, including government representatives and members of the nuclear and finance communities, as well as experts from the NEA and the OECD. Conference participants discussed the primary challenges faced by the markets, including how to secure financing for new nuclear projects, as well as approaches and solutions to such challenges. Through multiple expert presentations, moderated sessions and scenario discussions, participants acquired a better understanding of the unique challenges, approaches and techniques involved in financing new nuclear power plants. Throughout the conference, experts set the stage to understand why financing new NPPs is so difficult and complex. The following are the key challenges identified through discussions: - unstable electricity prices in a liberalized market; - electricity market designs that do not provide investment signals for low-carbon technologies; - insufficient carbon pricing to promote nuclear investments; - explicit governmental support for renewables; - uncertain and changing political support; - poor social and political perception of safety; - historical new nuclear project budget and schedule overruns; - long-term nature of capital investments. Final recommendations for consideration Conclusions were reached through discussions and debate on how to best address the aforementioned challenges. Although not all of these challenges can be resolved, there are methods to address the risks involved and to build the confidence necessary for investment. The key recommendations from the conference for financing new NPPs include: - conduct electricity market reform to level the playing field across all
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Directory of Open Access Journals (Sweden)
Eva Mateo-Marti
2014-08-01
Full Text Available The study of planetary environments of astrobiological interest has become a major challenge. Because of the obvious technical and economical limitations on in situ planetary exploration, laboratory simulations are one of the most feasible research options to make advances both in planetary science and in developing a consistent description of the origin of life. With this objective in mind, we applied vacuum technology to the design of versatile vacuum chambers devoted to the simulation of planetary atmospheres’ conditions. These vacuum chambers are able to simulate atmospheres and surface temperatures representative of the majority of planetary objects, and they are especially appropriate for studying the physical, chemical and biological changes induced in a particular sample by in situ irradiation or physical parameters in a controlled environment. Vacuum chambers are a promising potential tool in several scientific and technological fields, such as engineering, chemistry, geology and biology. They also offer the possibility of discriminating between the effects of individual physical parameters and selected combinations thereof. The implementation of our vacuum chambers in combination with analytical techniques was specifically developed to make feasible the in situ physico-chemical characterization of samples. Many wide-ranging applications in astrobiology are detailed herein to provide an understanding of the potential and flexibility of these experimental systems. Instruments and engineering technology for space applications could take advantage of our environment-simulation chambers for sensor calibration. Our systems also provide the opportunity to gain a greater understanding of the chemical reactivity of molecules on surfaces under different environments, thereby leading to a greater understanding of interface processes in prebiotic chemical reactions and facilitating studies of UV photostability and photochemistry on surfaces
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Scientific challenges of bioethanol production in Brazil
Energy Technology Data Exchange (ETDEWEB)
Amorim, Henrique V.; Lopes, Mario Lucio [Fermentec, Piracicaba, SP (Brazil); Castro Oliveira, Juliana Velasco de [Laboratorio Nacional de Ciencia e Tecnologia do Bioetanol (CTBE), Sao Paulo (Brazil); Buckeridge, Marcos S. [Laboratorio Nacional de Ciencia e Tecnologia do Bioetanol (CTBE), Sao Paulo (Brazil); Universidade de Sao Paulo, INCT do Bioetanol (Brazil). Dept. de Botanica; Goldman, Gustavo Henrique [Laboratorio Nacional de Ciencia e Tecnologia do Bioetanol (CTBE), Sao Paulo (Brazil); Universidade de Sao Paulo, INCT do Bioetanol (Brazil). Dept. de Ciencias Farmaceuticas
2011-09-15
Bioethanol (fuel alcohol) has been produced by industrial alcoholic fermentation processes in Brazil since the beginning of the twentieth century. Currently, 432 mills and distilleries crush about 625 million tons of sugarcane per crop, producing about 27 billion liters of ethanol and 38.7 million tons of sugar. The production of bioethanol from sugarcane represents a major large-scale technology capable of producing biofuel efficiently and economically, providing viable substitutes to gasoline. The combination of immobilization of CO{sub 2} by sugarcane crops by photosynthesis into biomass together with alcoholic fermentation of this biomass has allowed production of a clean and high-quality liquid fuel that contains 93% of the original energy found in sugar. Over the last 30 years, several innovations have been introduced to Brazilian alcohol distilleries resulting in the improvement of plant efficiency and economic competitiveness. Currently, the main scientific challenges are to develop new technologies for bioethanol production from first and second generation feedstocks that exhibit positive energy balances and appropriately meet environmental sustainability criteria. This review focuses on these aspects and provides special emphasis on the selection of new yeast strains, genetic breeding, and recombinant DNA technology, as applied to bioethanol production processes. (orig.)
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Addressing global change challenges for Central Asian socio-ecosystems
Qi, Jiaguo; Bobushev, Temirbek S.; Kulmatov, Rashid; Groisman, Pavel; Gutman, Garik
2012-06-01
Central Asia is one of the most vulnerable regions on the planet earth to global climate change, depending on very fragile natural resources. The Soviet legacy has left the five countries (Kazakhstan, Tajikistan, Kyrgyzstan, Turkmenistan, and Uzbekistan) with a highly integrated system but they are facing great challenges with tensions that hinder regional coordination of food and water resources. With increasing climate variability and warming trend in the region, food and water security issues become even more crucial now and, if not addressed properly, could affect the regional stability. The long-term drivers of these two most critical elements, food and water, are climate change; the immediate and probably more drastic factors affecting the food and water security are land uses driven by institutional change and economic incentives. As a feedback, changes in land use and land cover have directly implications on water uses, food production, and lifestyles of the rural community in the region. Regional and international efforts have been made to holistically understand the cause, extent, rate and societal implications of land use changes in the region. Much of these have been understood, or under investigation by various projects, but solutions or research effort to develop solutions, to these urgent regional issues are lacking. This article, serves as an introduction to the special issue, provides a brief overview of the challenges facing the Central Asian countries and various international efforts in place that resulted in the publications of this special issue.
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Hoang, L.P.; Biesbroek, R.; Tri, V.P.D.; Kummu, M.; van Vliet, M.T.H.; Leemans, R.; Kabat, P.; Ludwig, F.
2018-01-01
Climate change and accelerating socioeconomic developments increasingly challenge flood-risk management in the Vietnamese Mekong River Delta—a typical large, economically dynamic and highly vulnerable delta. This study identifies and addresses the emerging challenges for flood-risk management. Furthermore, we identify and analyse response solutions, focusing on meaningful configurations of the individual solutions and how they can be tailored to specific challenges using expert surveys, conte...
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The Challenge of Evaluating Students' Scientific Literacy in a Writing-to-Learn Context
Tomas, Louisa; Ritchie, Stephen M.
2015-01-01
This paper reports on the challenge of evaluating students' scientific literacy in a writing-to-learn context, as illustrated by our experience with an online science-writing project. In this mixed methods study, year 9 students in a case study class (13-14 year olds, n?=?26) authored a series of two "hybridised" short stories that…
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New challenges for Sportis Scientific Technical Journal
Directory of Open Access Journals (Sweden)
Víctor Arufe Giráldez
2015-09-01
Full Text Available In the publishing of this issue we want to advance two major events, the first of which is to inform the Sportis Magazine will from September 1, part of official scientific journal of the University of A Coruña, with this integration It aims to improve the dissemination of the journal in the most prestigious data bases of international level and contribute to the visibility of the University of A Coruña as committed to research in school sports college, psychomotor and Physical Education.The second story that we want to give is that the November 5-7 will be held at the Faculty of Education at the University of A Coruna, the V World Congress of Sports, Physical Education and Psychomotor School. You can participate by presenting a communication, poster or virtual poster, the best papers will be invited to publish their work as research article in the following issues of the magazine. Disponéis more information on the web www.sportis.es.In this third and final issue of the year, we beat record of article, in part due to the increase in the number of items received, a total of 10 works by experts and professionals from different countries will be published. Some of the issues addressed are: first aid teacher training, the attitude toward students with disabilities, futsal, using accelerometers, bodyboard training in young, innovative proposals such as the teaching unit based Hypopressive method, aquatic motor skills, study of sports organizations, studies involving different experts from different countries, analysis of skills in physical education ... Undoubtedly an interesting number to enjoy a good coffee or tea and gain greater technical and scientific knowledge.All equipment Sportis want is your pleasure this new publication and invite you to submit your work for future issues.Receive a warm greeting,Prof. Dr. Victor Arufe GiráldezChief Editor Sportis. International Journal of School Sports, Physical Education and Psychomotor
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Center for Center for Technology for Advanced Scientific Component Software (TASCS)
Energy Technology Data Exchange (ETDEWEB)
Kostadin, Damevski [Virginia State Univ., Petersburg, VA (United States)
2015-01-25
A resounding success of the Scientific Discovery through Advanced Computing (SciDAC) program is that high-performance computational science is now universally recognized as a critical aspect of scientific discovery [71], complementing both theoretical and experimental research. As scientific communities prepare to exploit unprecedented computing capabilities of emerging leadership-class machines for multi-model simulations at the extreme scale [72], it is more important than ever to address the technical and social challenges of geographically distributed teams that combine expertise in domain science, applied mathematics, and computer science to build robust and flexible codes that can incorporate changes over time. The Center for Technology for Advanced Scientific Component Software (TASCS)1 tackles these these issues by exploiting component-based software development to facilitate collaborative high-performance scientific computing.
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[Challenge and opportunity of entry to WTO brings to scientific and technological periodical].
Tian, Yun-Mei
2004-11-01
After our country enters WTO, confronted with the direct influence in big international market opening, editorial department will face fierce competition. Selecting the superior and eliminate the inferior will test every publishing house and every magazine directly. In order to improve the competition level, author has analyzed the current situation of China's periodical development, and then explored the scientific and technological periodical opportunity and challenge faced under the new situation.
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Addressing Open Water Data Challenges in the Bureau of Reclamation
Brekke, L. D.; Danner, A.; Nagode, J.; Rocha, J.; Poulton, S.; Anderson, A.
2017-12-01
The Bureau of Reclamation is largest wholesaler of water in the United States. Located in the 17 western states, Reclamation serves water to 31 million people, provides irrigated water to 20 percent of Western farmers, and is the second largest producer of hydroelectric power in the United States. Through these activities, Reclamation generates large amounts of water and water-related data, describing reservoirs and river system conditions, hydropower, environmental compliance activities, infrastructure assets, and other aspects of Reclamation's mission activities. Reclamation aims to make water and water-related data sets more easily found, accessed, and used in decision-making activities in order to benefit the public, private sector, and research communities. Historically, there has not been an integrated, bureau-wide system to store data in machine-readable formats; nor a system to permit centralized browsing, open access, and web-services. Reclamation began addressing these limitations by developing the Reclamation Water Information System (RWIS), released in Spring 2017 (https://water.usbr.gov/). A bureau-wide team contributed to RWIS development, including water data stewards, database administrators, and information technology (IT) specialists. The first RWIS release publishes reservoir time series data from Reclamation's five regions and includes a map interface for sites identification, a query interface for data discovery and access, and web-services for automated retrieval. As RWIS enhancement continues, the development team is developing a companion system - the Reclamation Information Sharing Environment (RISE) - to provide access to the other data subjects and types (geospatial, documents). While RWIS and RISE are promising starts, Reclamation continues to face challenges in addressing open water data goals: making data consolidation and open publishing a value-added activity for programs that publish data locally, going beyond providing open access
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Exploring HPCS languages in scientific computing
International Nuclear Information System (INIS)
Barrett, R F; Alam, S R; Almeida, V F d; Bernholdt, D E; Elwasif, W R; Kuehn, J A; Poole, S W; Shet, A G
2008-01-01
As computers scale up dramatically to tens and hundreds of thousands of cores, develop deeper computational and memory hierarchies, and increased heterogeneity, developers of scientific software are increasingly challenged to express complex parallel simulations effectively and efficiently. In this paper, we explore the three languages developed under the DARPA High-Productivity Computing Systems (HPCS) program to help address these concerns: Chapel, Fortress, and X10. These languages provide a variety of features not found in currently popular HPC programming environments and make it easier to express powerful computational constructs, leading to new ways of thinking about parallel programming. Though the languages and their implementations are not yet mature enough for a comprehensive evaluation, we discuss some of the important features, and provide examples of how they can be used in scientific computing. We believe that these characteristics will be important to the future of high-performance scientific computing, whether the ultimate language of choice is one of the HPCS languages or something else
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Exploring HPCS languages in scientific computing
Barrett, R. F.; Alam, S. R.; Almeida, V. F. d.; Bernholdt, D. E.; Elwasif, W. R.; Kuehn, J. A.; Poole, S. W.; Shet, A. G.
2008-07-01
As computers scale up dramatically to tens and hundreds of thousands of cores, develop deeper computational and memory hierarchies, and increased heterogeneity, developers of scientific software are increasingly challenged to express complex parallel simulations effectively and efficiently. In this paper, we explore the three languages developed under the DARPA High-Productivity Computing Systems (HPCS) program to help address these concerns: Chapel, Fortress, and X10. These languages provide a variety of features not found in currently popular HPC programming environments and make it easier to express powerful computational constructs, leading to new ways of thinking about parallel programming. Though the languages and their implementations are not yet mature enough for a comprehensive evaluation, we discuss some of the important features, and provide examples of how they can be used in scientific computing. We believe that these characteristics will be important to the future of high-performance scientific computing, whether the ultimate language of choice is one of the HPCS languages or something else.
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International Nuclear Information System (INIS)
2007-01-01
Over the past two decades, the IAEA has conducted a series of major conferences that have addressed topical issues and strategies critical to nuclear safety for consideration by the world's nuclear regulators. More recently, the IAEA organized the International Conference on Effective Nuclear Regulatory Systems - Facing Safety and Security Challenges, held in Moscow in 2006. The Moscow conference was the first of its kind, because it brought together senior regulators of nuclear safety, radiation safety and security from around the world to discuss how to improve regulatory effectiveness with the objective of improving the protection of the public and the users of nuclear and radioactive material. The International Conference on Challenges Faced by Technical and Scientific Support Organizations in Enhancing Nuclear Safety was held in Aix-en-Provence, France, from 23 to 27 April 2007. This conference, again, was the first of its kind, because it was the first to address technical and scientific support organizations (TSOs), the role they play in supporting either the national regulatory bodies or the industry in making optimum safety decisions and the challenges they face in providing this support. This conference provided a forum for the TSOs to discuss these and other issues with the organizations to which they provide this support - that is, the regulators and the operators/industry - as well as with other stakeholders such as research organizations and public authorities. This conference can also be considered to have a link to the Moscow conference. The Moscow conference concluded that effective regulation of nuclear safety is vital for the safe use of nuclear energy and associated technologies, both now and in the future, and is an essential prerequisite for establishing an effective Global Nuclear Safety Regime. The Moscow conference also highlighted the importance of continued and improved international cooperation in the area of nuclear safety. These
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Challenges of Teaching Science to Address Global Sustainability
Halim, Lilia
2015-01-01
For a liveable condition in this post- industrial era, it would depend on our ability to understand and use the science and technology advancement in a responsible manner. Water pollution and global warming phenomena are outcomes of scientific and technological advancement that has been mismanaged. One way to achieve global sustainability is through science education and the development of a scientific literate citizen. This paper, based on the literature and research work in science educatio...
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Cell and Gene Therapies: European View on Challenges in Translation and How to Address Them
Directory of Open Access Journals (Sweden)
Cécile F. Rousseau
2018-05-01
Full Text Available Advanced therapy medicinal products (ATMPs, i.e., cell and gene therapy products, is a rapidly evolving field of therapeutic development. A significant proportion of the products are being developed by academia or small/medium-sized enterprises (SMEs. The many challenges in translation posed by this class of products include aspects covering: manufacturing, non-clinical development plan as relevant to clinical trial, marketing authorization, and reimbursement. In this context, the term translation refers to the relevance of non-clinical data in relation to how it impacts on appropriate and efficient clinical development. In order to successfully overcome these challenges, a clear understanding of the requirements and expectations of all the stakeholders is critical. This article aims to cover the potential challenges related to such translation and suggested approaches to find solutions based on experience and learnings from the perspective of European Union. While commercial challenges have a significant impact on the ATMPs in general, it is considered outside the scope of this article. However, by adopting a strong scientific basis for translation as suggested in this article, it is likely such an approach would help rather than harm successful real world clinical use of ATMPs.
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In search of biomarkers for autism: scientific, social and ethical challenges.
Walsh, Pat; Elsabbagh, Mayada; Bolton, Patrick; Singh, Ilina
2011-09-20
There is widespread hope that the discovery of valid biomarkers for autism will both reveal the causes of autism and enable earlier and more targeted methods for diagnosis and intervention. However, growing enthusiasm about recent advances in this area of autism research needs to be tempered by an awareness of the major scientific challenges and the important social and ethical concerns arising from the development of biomarkers and their clinical application. Collaborative approaches involving scientists and other stakeholders must combine the search for valid, clinically useful autism biomarkers with efforts to ensure that individuals with autism and their families are treated with respect and understanding.
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Addressing practical challenges in utility optimization of mobile wireless sensor networks
Eswaran, Sharanya; Misra, Archan; La Porta, Thomas; Leung, Kin
2008-04-01
This paper examines the practical challenges in the application of the distributed network utility maximization (NUM) framework to the problem of resource allocation and sensor device adaptation in a mission-centric wireless sensor network (WSN) environment. By providing rich (multi-modal), real-time information about a variety of (often inaccessible or hostile) operating environments, sensors such as video, acoustic and short-aperture radar enhance the situational awareness of many battlefield missions. Prior work on the applicability of the NUM framework to mission-centric WSNs has focused on tackling the challenges introduced by i) the definition of an individual mission's utility as a collective function of multiple sensor flows and ii) the dissemination of an individual sensor's data via a multicast tree to multiple consuming missions. However, the practical application and performance of this framework is influenced by several parameters internal to the framework and also by implementation-specific decisions. This is made further complex due to mobile nodes. In this paper, we use discrete-event simulations to study the effects of these parameters on the performance of the protocol in terms of speed of convergence, packet loss, and signaling overhead thereby addressing the challenges posed by wireless interference and node mobility in ad-hoc battlefield scenarios. This study provides better understanding of the issues involved in the practical adaptation of the NUM framework. It also helps identify potential avenues of improvement within the framework and protocol.
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Addressing contrasting cognitive models in scientific collaboration
Diviacco, P.
2012-04-01
If the social aspects of scientific communities and their internal dynamics is starting to be recognized and acknowledged in the everyday lives of scientists, it is rather difficult for them to find tools that could support their activities consistently with this perspective. Issues span from gathering researchers to mutual awareness, from information sharing to building meaning, with the last one being particularly critical in research fields as the geo-sciences, that deal with the reconstruction of unique, often non-reproducible, and contingent processes. Reasoning here is, in fact, mainly abductive, allowing multiple and concurrent explanations for the same phenomenon to coexist. Scientists bias one hypothesis over another not only on strictly logical but also on sociological motivations. Following a vision, scientists tend to evolve and isolate themselves from other scientists creating communities characterized by different cognitive models, so that after some time these become incompatible and scientists stop understanding each other. We address these problems as a communication issue so that the classic distinction into three levels (syntactic, semantic and pragmatic) can be used. At the syntactic level, we highlight non-technical obstacles that condition interoperability and data availability and transparency. At the semantic level, possible incompatibilities of cognitive models are particularly evident, so that using ontologies, cross-domain reconciliation should be applied. This is a very difficult task to perform since the projection of knowledge by scientists, in the designated community, is political and thus can create a lot of tension. The strategy we propose to overcome these issues pertains to pragmatics, in the sense that it is intended to acknowledge the cultural and personal factors each partner brings into the collaboration and is based on the idea that meaning should remain a flexible and contingent representation of possibly divergent views
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Directory of Open Access Journals (Sweden)
Iribarren-Maestro Isabel
2006-10-01
Full Text Available Abstract Background The purpose of this study is to analyse the trends in scientific research on transmissible spongiform encephalopathies by applying bibliometric tools to the scientific literature published between 1973 and 2002. Methods The data for the study were obtained from Medline database, in order to determine the volume of scientific output in the above period, the countries involved, the type of document and the trends in the subject matters addressed. The period 1973–2002 was divided in three sub-periods. Results We observed a significant growth in scientific production. The percentage of increase is 871.7 from 1973 to 2002. This is more evident since 1991 and particularly in the 1996–2001 period. The countries found to have the highest output were the United States, the United Kingdom, Japan, France and Germany. The evolution in the subject matters was almost constant in the three sub-periods in which the study was divided. In the first and second sub-periods, the subject matters of greatest interest were more general, i.e Nervous system or Nervous system diseases, Creutzfeldt-Jakob disease, Scrapie, and Chemicals and Drugs, but in the last sub-period, some changes were observed because the Prion-related matters had the greatest presence. Collaboration among authors is small from 1973 to 1992, but increases notably in the third sub-period, and also the number of authors and clusters formed. Some of the authors, like Gajdusek or Prusiner, appear in the whole period. Conclusion The study reveals a very high increase in scientific production. It is related also with the beginnings of research on bovine spongiform encephalopathy and variant Creutzfeldt-Jakob disease, with the establishment of progressive collaboration relationships and a reflection of public health concerns about this problem.
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Goldstein, Benjamin A; Navar, Ann Marie; Carter, Rickey E
2017-06-14
Risk prediction plays an important role in clinical cardiology research. Traditionally, most risk models have been based on regression models. While useful and robust, these statistical methods are limited to using a small number of predictors which operate in the same way on everyone, and uniformly throughout their range. The purpose of this review is to illustrate the use of machine-learning methods for development of risk prediction models. Typically presented as black box approaches, most machine-learning methods are aimed at solving particular challenges that arise in data analysis that are not well addressed by typical regression approaches. To illustrate these challenges, as well as how different methods can address them, we consider trying to predicting mortality after diagnosis of acute myocardial infarction. We use data derived from our institution's electronic health record and abstract data on 13 regularly measured laboratory markers. We walk through different challenges that arise in modelling these data and then introduce different machine-learning approaches. Finally, we discuss general issues in the application of machine-learning methods including tuning parameters, loss functions, variable importance, and missing data. Overall, this review serves as an introduction for those working on risk modelling to approach the diffuse field of machine learning. © The Author 2016. Published by Oxford University Press on behalf of the European Society of Cardiology.
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Anixt, Julia S; Meinzen-Derr, Jareen; Estridge, Halley; Smith, Laura; Brinkman, William B
2018-05-01
To describe the characteristics of treatment decisions to address challenging behaviors in children with autism spectrum disorder (ASD). Parents of children aged 4 to 15 years with ASD seen in a developmental behavioral pediatric (DBP) clinic completed validated measures to characterize their child's behaviors and their own level of stress. Parents reported their treatment priority before the visit. During the visit, we assessed shared decision making (SDM) using the Observing Patient Involvement (OPTION) scale and alignment of the clinician's treatment plan with the parent's priority. Before and after the visit, parents rated their uncertainty about the treatment plan using the Decisional Conflict Scale (DCS). We calculated descriptive statistics for the measures. Fifty-four families participated. Children were a mean (SD) age of 8.8 (3.3) years, and 87% were male. Children had a variety of behavioral challenges, and parents reported high levels of stress. Commonly reported parent treatment priorities were hyperactivity, tantrums, anxiety, and poor social skills. Levels of SDM were low, with a mean (SD) OPTION score of 24.5 (9.7). Parent priorities were addressed in 65% of treatment plans. Approximately 69% of parents had elevated DCS scores before the visit. Although levels of decisional conflict were lower after the visit compared with before the visit (p < 0.03), 46% of parents continued to report high scores on the DCS. Parents leave DBP visits with feelings of uncertainty about treatment decisions and with treatment plans that do not always address their priorities. SDM interventions hold promise to improve the quality of ASD treatment decisions.
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The next organizational challenge: finding and addressing diagnostic error.
Graber, Mark L; Trowbridge, Robert; Myers, Jennifer S; Umscheid, Craig A; Strull, William; Kanter, Michael H
2014-03-01
Although health care organizations (HCOs) are intensely focused on improving the safety of health care, efforts to date have almost exclusively targeted treatment-related issues. The literature confirms that the approaches HCOs use to identify adverse medical events are not effective in finding diagnostic errors, so the initial challenge is to identify cases of diagnostic error. WHY HEALTH CARE ORGANIZATIONS NEED TO GET INVOLVED: HCOs are preoccupied with many quality- and safety-related operational and clinical issues, including performance measures. The case for paying attention to diagnostic errors, however, is based on the following four points: (1) diagnostic errors are common and harmful, (2) high-quality health care requires high-quality diagnosis, (3) diagnostic errors are costly, and (4) HCOs are well positioned to lead the way in reducing diagnostic error. FINDING DIAGNOSTIC ERRORS: Current approaches to identifying diagnostic errors, such as occurrence screens, incident reports, autopsy, and peer review, were not designed to detect diagnostic issues (or problems of omission in general) and/or rely on voluntary reporting. The realization that the existing tools are inadequate has spurred efforts to identify novel tools that could be used to discover diagnostic errors or breakdowns in the diagnostic process that are associated with errors. New approaches--Maine Medical Center's case-finding of diagnostic errors by facilitating direct reports from physicians and Kaiser Permanente's electronic health record--based reports that detect process breakdowns in the followup of abnormal findings--are described in case studies. By raising awareness and implementing targeted programs that address diagnostic error, HCOs may begin to play an important role in addressing the problem of diagnostic error.
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Andenoro, Anthony C.; Sowcik, Matthew J.; Balser, Teresa C.
2017-01-01
Complex and adaptive challenges threaten human well-being and sustainability. However, our leadership graduates often lack the capacity and or commitment to address these challenges in a meaningful way. This paper details a five-year study exploring the impact of an interdisciplinary undergraduate course on the development of global capacities,…
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Global challenges keynote address in memoriam to colleagues lost in the Malaysia airlines 17 crash.
Hankins, Catherine A
2016-01-01
Six colleagues working in the HIV field were killed when their flight en route to Kuala Lumpur was shot down over the Ukraine. This report is drawn from the in memoriam keynote opening address given at the 12th International AIDS Impact conference in Amsterdam in 2015. It highlights their tangible and valued roles in the HIV response and looks forward to the road ahead. It describes the ways in which we can build on their legacy to address current global challenges in HIV prevention and treatment and to mobilise the intensified, focused resources that are needed to turn the HIV epidemic on its head.
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Colquhoun, Amy; Aplin, Laura; Geary, Janis; Goodman, Karen J; Hatcher, Juanita
2012-05-08
Population health data are vital for the identification of public health problems and the development of public health strategies. Challenges arise when attempts are made to disseminate or access anonymised data that are deemed to be potentially identifiable. In these situations, there is debate about whether the protection of an individual's privacy outweighs potentially beneficial public health initiatives developed using potentially identifiable information. While these issues have an impact at planning and policy levels, they pose a particular dilemma when attempting to examine and address community concerns about a specific health problem. Research currently underway in northern Canadian communities on the frequency of Helicobacter pylori infection and associated diseases, such as stomach cancer, is used in this article to illustrate the challenges that data controls create on the ability of researchers and health officials to address community concerns. Barriers are faced by public health professionals and researchers when endeavouring to address community concerns; specifically, provincial cancer surveillance departments and community-driven participatory research groups face challenges related to data release or access that inhibit their ability to effectively address community enquiries. The resulting consequences include a limited ability to address misinformation or to alleviate concerns when dealing with health problems in small communities. The development of communication tools and building of trusting relationships are essential components of a successful investigation into community health concerns. It may also be important to consider that public wellbeing may outweigh the value of individual privacy in these situations. As such, a re-evaluation of data disclosure policies that are applicable in these circumstances should be considered.
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Addressing South Africa’s urban challenges
Directory of Open Access Journals (Sweden)
Jayne M. Rogerson
2014-07-01
Full Text Available South Africa is among the most urbanized countries in Africa and has an urban population that is growing rapidly. The country’s urban challenges sometimes are considered as distinctive and separate to those of rest of Africa because of the apartheid legacy of a fragmented and racially splintered urban landscape. Nevertheless, 20 years after democratic transition the issues that confront its cities increasingly exhibit a set of sustainability challenges that typify those problems of many other fast-growing African urban areas. This introduction locates the collection of articles as a contribution to the expanding corpus of scholarship on urban South Africa.
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Testing Scientific Software: A Systematic Literature Review
Kanewala, Upulee; Bieman, James M.
2014-01-01
Context Scientific software plays an important role in critical decision making, for example making weather predictions based on climate models, and computation of evidence for research publications. Recently, scientists have had to retract publications due to errors caused by software faults. Systematic testing can identify such faults in code. Objective This study aims to identify specific challenges, proposed solutions, and unsolved problems faced when testing scientific software. Method We conducted a systematic literature survey to identify and analyze relevant literature. We identified 62 studies that provided relevant information about testing scientific software. Results We found that challenges faced when testing scientific software fall into two main categories: (1) testing challenges that occur due to characteristics of scientific software such as oracle problems and (2) testing challenges that occur due to cultural differences between scientists and the software engineering community such as viewing the code and the model that it implements as inseparable entities. In addition, we identified methods to potentially overcome these challenges and their limitations. Finally we describe unsolved challenges and how software engineering researchers and practitioners can help to overcome them. Conclusions Scientific software presents special challenges for testing. Specifically, cultural differences between scientist developers and software engineers, along with the characteristics of the scientific software make testing more difficult. Existing techniques such as code clone detection can help to improve the testing process. Software engineers should consider special challenges posed by scientific software such as oracle problems when developing testing techniques. PMID:25125798
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Testing Scientific Software: A Systematic Literature Review.
Kanewala, Upulee; Bieman, James M
2014-10-01
Scientific software plays an important role in critical decision making, for example making weather predictions based on climate models, and computation of evidence for research publications. Recently, scientists have had to retract publications due to errors caused by software faults. Systematic testing can identify such faults in code. This study aims to identify specific challenges, proposed solutions, and unsolved problems faced when testing scientific software. We conducted a systematic literature survey to identify and analyze relevant literature. We identified 62 studies that provided relevant information about testing scientific software. We found that challenges faced when testing scientific software fall into two main categories: (1) testing challenges that occur due to characteristics of scientific software such as oracle problems and (2) testing challenges that occur due to cultural differences between scientists and the software engineering community such as viewing the code and the model that it implements as inseparable entities. In addition, we identified methods to potentially overcome these challenges and their limitations. Finally we describe unsolved challenges and how software engineering researchers and practitioners can help to overcome them. Scientific software presents special challenges for testing. Specifically, cultural differences between scientist developers and software engineers, along with the characteristics of the scientific software make testing more difficult. Existing techniques such as code clone detection can help to improve the testing process. Software engineers should consider special challenges posed by scientific software such as oracle problems when developing testing techniques.
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XVis: Visualization for the Extreme-Scale Scientific-Computation Ecosystem: Year-end report FY17.
Energy Technology Data Exchange (ETDEWEB)
Moreland, Kenneth D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Pugmire, David [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Rogers, David [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Childs, Hank [Univ. of Oregon, Eugene, OR (United States); Ma, Kwan-Liu [Univ. of California, Davis, CA (United States); Geveci, Berk [Kitware, Inc., Clifton Park, NY (United States)
2017-10-01
The XVis project brings together the key elements of research to enable scientific discovery at extreme scale. Scientific computing will no longer be purely about how fast computations can be performed. Energy constraints, processor changes, and I/O limitations necessitate significant changes in both the software applications used in scientific computation and the ways in which scientists use them. Components for modeling, simulation, analysis, and visualization must work together in a computational ecosystem, rather than working independently as they have in the past. This project provides the necessary research and infrastructure for scientific discovery in this new computational ecosystem by addressing four interlocking challenges: emerging processor technology, in situ integration, usability, and proxy analysis.
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Topic 14+16: High-performance and scientific applications and extreme-scale computing (Introduction)
Downes, Turlough P.
2013-01-01
As our understanding of the world around us increases it becomes more challenging to make use of what we already know, and to increase our understanding still further. Computational modeling and simulation have become critical tools in addressing this challenge. The requirements of high-resolution, accurate modeling have outstripped the ability of desktop computers and even small clusters to provide the necessary compute power. Many applications in the scientific and engineering domains now need very large amounts of compute time, while other applications, particularly in the life sciences, frequently have large data I/O requirements. There is thus a growing need for a range of high performance applications which can utilize parallel compute systems effectively, which have efficient data handling strategies and which have the capacity to utilise current and future systems. The High Performance and Scientific Applications topic aims to highlight recent progress in the use of advanced computing and algorithms to address the varied, complex and increasing challenges of modern research throughout both the "hard" and "soft" sciences. This necessitates being able to use large numbers of compute nodes, many of which are equipped with accelerators, and to deal with difficult I/O requirements. © 2013 Springer-Verlag.
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Leveraging Big Data Tools and Technologies: Addressing the Challenges of the Water Quality Sector
Directory of Open Access Journals (Sweden)
Juan Manuel Ponce Romero
2017-11-01
Full Text Available The water utility sector is subject to stringent legislation, seeking to address both the evolution of practices within the chemical/pharmaceutical industry, and the safeguarding of environmental protection, and which is informed by stakeholder views. Growing public environmental awareness is balanced by fair apportionment of liability within-sector. This highly complex and dynamic context poses challenges for water utilities seeking to manage the diverse chemicals arising from disparate sources reaching Wastewater Treatment Plants, including residential, commercial, and industrial points of origin, and diffuse sources including agricultural and hard surface water run-off. Effluents contain broad ranges of organic and inorganic compounds, herbicides, pesticides, phosphorus, pharmaceuticals, and chemicals of emerging concern. These potential pollutants can be in dissolved form, or arise in association with organic matter, the associated risks posing significant environmental challenges. This paper examines how the adoption of new Big Data tools and computational technologies can offer great advantage to the water utility sector in addressing this challenge. Big Data approaches facilitate improved understanding and insight of these challenges, by industry, regulator, and public alike. We discuss how Big Data approaches can be used to improve the outputs of tools currently in use by the water industry, such as SAGIS (Source Apportionment GIS system, helping to reveal new relationships between chemicals, the environment, and human health, and in turn provide better understanding of contaminants in wastewater (origin, pathways, and persistence. We highlight how the sector can draw upon Big Data tools to add value to legacy datasets, such as the Chemicals Investigation Programme in the UK, combined with contemporary data sources, extending the lifespan of data, focusing monitoring strategies, and helping users adapt and plan more efficiently. Despite
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Mtove, George; Kimani, Joshua; Kisinza, William; Makenga, Geofrey; Mangesho, Peter; Duparc, Stephan; Nakalembe, Miriam; Phiri, Kamija S; Orrico, Russell; Rojo, Ricardo; Vandenbroucke, Pol
2018-03-22
Multinational clinical trials are logistically complex and require close coordination between various stakeholders. They must comply with global clinical standards and are accountable to multiple regulatory and ethical bodies. In resource-limited settings, it is challenging to understand how to apply global clinical standards to international, national, and local factors in clinical trials, making multiple-level stakeholder engagement an important element in the successful conduct of these clinical trials. During the planning and implementation of a large multinational clinical trial for intermittent preventive treatment of malaria in pregnancy in resource-limited areas of sub-Saharan Africa, we encountered numerous challenges, which required implementation of a range of engagement measures to ensure compliance with global clinical and regulatory standards. These challenges included coordination with ongoing global malaria efforts, heterogeneity in national regulatory structures, sub-optimal healthcare infrastructure, local practices and beliefs, and perspectives that view healthcare providers with undue trust or suspicion. In addition to engagement with international bodies, such as the World Health Organization, the Malaria in Pregnancy Consortium, the Steve Biko Centre for Bioethics, and the London School of Hygiene and Tropical Medicine, in order to address the challenges just described, Pfizer Inc. and Medicines for Malaria Venture (the "Sponsoring Entities" for these studies) and investigators liaised with national- and district-level stakeholders such as health ministers and regional/local community health workers. Community engagement measures undertaken by investigators included local meetings with community leaders to explain the research aims and answer questions and concerns voiced by the community. The investigators also engaged with family members of prospective trial participants in order to be sensitive to local practices and beliefs. Engagement
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Ogbogu, Ubaka; Burningham, Sarah; Ollenberger, Adam; Calder, Kathryn; Du, Li; El Emam, Khaled; Hyde-Lay, Robyn; Isasi, Rosario; Joly, Yann; Kerr, Ian; Malin, Bradley; McDonald, Michael; Penney, Steven; Piat, Gayle; Roy, Denis-Claude; Sugarman, Jeremy; Vercauteren, Suzanne; Verhenneman, Griet; West, Lori; Caulfield, Timothy
2014-02-03
The increased use of human biological material for cell-based research and clinical interventions poses risks to the privacy of patients and donors, including the possibility of re-identification of individuals from anonymized cell lines and associated genetic data. These risks will increase as technologies and databases used for re-identification become affordable and more sophisticated. Policies that require ongoing linkage of cell lines to donors' clinical information for research and regulatory purposes, and existing practices that limit research participants' ability to control what is done with their genetic data, amplify the privacy concerns. To date, the privacy issues associated with cell-based research and interventions have not received much attention in the academic and policymaking contexts. This paper, arising out of a multi-disciplinary workshop, aims to rectify this by outlining the issues, proposing novel governance strategies and policy recommendations, and identifying areas where further evidence is required to make sound policy decisions. The authors of this paper take the position that existing rules and norms can be reasonably extended to address privacy risks in this context without compromising emerging developments in the research environment, and that exceptions from such rules should be justified using a case-by-case approach. In developing new policies, the broader framework of regulations governing cell-based research and related areas must be taken into account, as well as the views of impacted groups, including scientists, research participants and the general public. This paper outlines deliberations at a policy development workshop focusing on privacy challenges associated with cell-based research and interventions. The paper provides an overview of these challenges, followed by a discussion of key themes and recommendations that emerged from discussions at the workshop. The paper concludes that privacy risks associated with cell
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Moreno, Gerardo; Bullock, Lyndal M.
2011-01-01
The Functional Behavioural Assessment (FBA) is an investigative process that examines the context of challenging behaviours in the classroom. Information gleaned from the FBA process is used to develop a behaviour intervention plan to address the challenging behaviour and teach a socially acceptable replacement behaviour. However, the FBA has…
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Pumped Storage Power plants, Challenges and opportunities - Some conclusions
International Nuclear Information System (INIS)
Viollet, Pierre-Louis; Roult, Didier; Mathex, Bruno; Ouaabi, Aziz; Louis, Frederic; Petitjean, Alain; Capuozzo, Vincent; Mazzouji, Farid; Prestat, Bruno; Nekrassov, Andrei; Caignaert, Guy; Vidil, Roland; Guilbaud, Claude; Metais, Olivier
2011-11-01
This document briefly synthesizes a conference which addressed the development of pumped storage power plants in the world, and social, economic, technical and scientific challenges related to this development which is closely related to the development of intermittent renewable energies (wind and solar energy). Current developments in different countries (Germany, Portugal, Switzerland, Norway, France and China) are evoked
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Addressing challenges for youths with mobility devices in winter conditions.
Morales, Ernesto; Lindsay, Sally; Edwards, Geoffrey; Howell, Lori; Vincent, Claude; Yantzi, Nicole; Gauthier, Véronique
2018-01-01
Winter-related research about the experience of navigating in the urban context has mostly focused on the elderly population with physical disabilities. The aim of this project was to explore potential design solutions to enhance young people's mobility devices and the built environment to improve accessibility and participation in winter. A multi-method qualitative design process included the following steps: (1) in-depth interviews; (2) photo elicitation; (3) individual co-design sessions; and (4) group co-design sessions (i.e., focus group). The participants were 13 youths (nine males and four females), aged 12-21, who used a wheelchair (12 power chair users and one manual wheelchair), for some with their parents, others without their parents, according to the parents' willingness to participate or not in the study (n = 13). The first two authors conducted group co-design sessions with mechanical engineers and therapists/clinicians in two Canadian cities to discuss the feasibility of the designs. Results (findings): The youths and their parents reported different winter-related challenges and proposed specific design solutions to enhance their participation and inclusion in winter activities. Seven of these designs were presented at two group co-design sessions of therapists/clinicians and engineers. Two designs were found to be feasible: (1) a traction device for wheelchairs in snow and (2) a mat made of rollers to clean snow and dirt from tires. The results of this research highlight the frustrations and challenges youths who use wheelchairs encounter in winter and a need for new solutions to ensure greater accessibility in winter. Therapists/clinicians and designers should address winter-related accessibility problems in areas with abundant snow. Implications for Rehabilitation Several studies show that current urban contexts do not necessarily respond accurately to the needs of individuals with limited mobility. Winter-related research about the
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Addressing professional resource challenges facing modern utilities with technological solutions
Energy Technology Data Exchange (ETDEWEB)
Goldie, T. [Hydro One Networks Inc., Toronto, ON (Canada); Hodder, S. [GE Digital Energy, Toronto, ON (Canada)
2008-07-01
The challenges facing electric utilities regarding a shortage of highly qualified labour to maintain, refurbish and expand electrical infrastructure can be attributed to a wave of retirements in skilled employees, a shortage of entry-level workers and a rapidly increasing workload caused by investment in electricity infrastructure. Two solutions were presented for finding and sustaining an adequate personnel base. The first involved developing local talent, both entry-level and mid-career staff to ensure that work continuity and workplace safety are maintained. The second involved the implementation of technological solutions to help optimize the use of existing and future labour resources. This paper presented the human resource programs developed by Hydro One, the largest electrical transmission and distribution utility in the province of Ontario. Their initiatives include raising the profile of the utility work environment through strategic partnerships with educational institutions and developing in house offerings to supplement existing academic programs. This paper also presented a technical solution to address the resources challenges specifically associated with power system protection and control. The solution targets professional and skilled trades involved in the design, installation and maintenance of automated substations and protection and control systems. It is based on the premise that resource optimization can be achieved by reducing inconsistent design and construction practices and replacing these designs with highly standardized materials with digital communications using IEC 61850. This new technology should attract young professionals to the power engineering field while still maintaining a high comfort level with the established professional workforce. 5 refs., 4 figs.
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Scientific Culture Measures: Challenges and New Perspectives
Energy Technology Data Exchange (ETDEWEB)
Lopez Cerezo, J.L.; Muñoz van den Eynde, A
2016-07-01
Since mid-twentieth century, efforts to promote scientific and technological development and engage the public in R&D process are increasing. Among those efforts, since the 1970s first in United States and then in United Kingdom and Europe, governments have funded surveys aimed at understanding the public attitudes toward science, scientists, and science policy. The Science and Engineering Indicators series of the National Science Foundation, or the European Community through its Special Eurobarometer on Europeans, science and technology, have shaped the research, measures and indicators of public understanding of science surveys. Examples are, at international level, surveys like Scientific Culture in IberoAmerican Countries (2009, FECYT-OEI-RICYT), or the International Study on Scientific Culture (2012, BBVA Foundation); and at national level, surveys like Social Perception of Science and Technology (2002-2014) series, or the recent Perception, Interest, Knowledge, and Actions (PIKA) Survey (2014), both funded by Spanish Government through its Spanish Foundation for Science and Technology (FECYT). (Author)
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Nanomedicines: addressing the scientific and regulatory gap.
Tinkle, Sally; McNeil, Scott E; Mühlebach, Stefan; Bawa, Raj; Borchard, Gerrit; Barenholz, Yechezkel Chezy; Tamarkin, Lawrence; Desai, Neil
2014-04-01
Nanomedicine is the application of nanotechnology to the discipline of medicine: the use of nanoscale materials for the diagnosis, monitoring, control, prevention, and treatment of disease. Nanomedicine holds tremendous promise to revolutionize medicine across disciplines and specialties, but this promise has yet to be fully realized. Beyond the typical complications associated with drug development, the fundamentally different and novel physical and chemical properties of some nanomaterials compared to materials on a larger scale (i.e., their bulk counterparts) can create a unique set of opportunities as well as safety concerns, which have only begun to be explored. As the research community continues to investigate nanomedicines, their efficacy, and the associated safety issues, it is critical to work to close the scientific and regulatory gaps to assure that nanomedicine drives the next generation of biomedical innovation. © 2014 New York Academy of Sciences.
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Addressing Criticisms of Large-Scale Marine Protected Areas
Ban, Natalie C; Fernandez, Miriam; Friedlander, Alan M; García-Borboroglu, Pablo; Golbuu, Yimnang; Guidetti, Paolo; Harris, Jean M; Hawkins, Julie P; Langlois, Tim; McCauley, Douglas J; Pikitch, Ellen K; Richmond, Robert H; Roberts, Callum M
2018-01-01
Abstract Designated large-scale marine protected areas (LSMPAs, 100,000 or more square kilometers) constitute over two-thirds of the approximately 6.6% of the ocean and approximately 14.5% of the exclusive economic zones within marine protected areas. Although LSMPAs have received support among scientists and conservation bodies for wilderness protection, regional ecological connectivity, and improving resilience to climate change, there are also concerns. We identified 10 common criticisms of LSMPAs along three themes: (1) placement, governance, and management; (2) political expediency; and (3) social–ecological value and cost. Through critical evaluation of scientific evidence, we discuss the value, achievements, challenges, and potential of LSMPAs in these arenas. We conclude that although some criticisms are valid and need addressing, none pertain exclusively to LSMPAs, and many involve challenges ubiquitous in management. We argue that LSMPAs are an important component of a diversified management portfolio that tempers potential losses, hedges against uncertainty, and enhances the probability of achieving sustainably managed oceans. PMID:29731514
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International Nuclear Information System (INIS)
Weinberg, A.M.
1997-01-01
Today, for the first time, scientific concerns are seriously being addressed that span future times--hundreds, even thousands, or more years in the future. One is witnessing what the author calls scientific millenarianism. Are such concerns for the distant future exercises in futility, or are they real issues that, to the everlasting gratitude of future generations, this generation has identified, warned about and even suggested how to cope with in the distant future? Can the four potential catastrophes--bolide impact, CO 2 warming, radioactive wastes and thermonuclear war--be avoided by technical fixes, institutional responses, religion, or by doing nothing? These are the questions addressed in this paper
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McPhaden, Michael; Davidson, Eric; McEntee, Christine; Williams, Billy
2017-04-01
The American Geophysical Union (AGU), a scientific society of 62,000 members worldwide, has established a set of scientific integrity and professional ethics guidelines for the actions of its members, for the governance of the union in its internal activities, and for the operations and participation in its publications and scientific meetings. More recently AGU has undertaken strategies and actions to help address the issue of harassment in the sciences and other work climate issues. This presentation will provide an overview of the role of scientific societies in helping to address these important issues, as well as specific strategies and actions underway at AGU and other societies. Progress to date and remaining challenges of this effort will be discussed, including AGU's work to provide additional program strength in this area.
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Hourd, Paul; Ginty, Patrick; Chandra, Amit; Williams, David J
2014-08-01
Manufacturing of more-than-minimally manipulated autologous cell therapies presents a number of unique challenges driven by complex supply logistics and the need to scale out production to multiple manufacturing sites or near the patient within hospital settings. The existing regulatory structure in Europe and the United States imposes a requirement to establish and maintain comparability between sites. Under a single market authorization, this is likely to become an unsurmountable burden beyond two or three sites. Unless alternative manufacturing approaches can be found to bridge the regulatory challenge of comparability, realizing a sustainable and investable business model for affordable autologous cell therapy supply is likely to be extremely demanding. Without a proactive approach by the regulators to close this "translational gap," these products may not progress down the development pipeline, threatening patient accessibility to an increasing number of clinician-led autologous cellular therapies that are already demonstrating patient benefits. We propose three prospective manufacturing models for the scale out/roll out of more-than-minimally manipulated clinically led autologous cell therapy products and test their prospects for addressing the challenge of product comparability with a selected expert reference panel of US and UK thought leaders. This paper presents the perspectives and insights of the panel and identifies where operational, technological and scientific improvements should be prioritized. The main purpose of this report is to solicit feedback and seek input from key stakeholders active in the field of autologous cell therapy in establishing a consensus-based manufacturing approach that may permit the roll out of clinically led autologous cell therapies. Copyright © 2014 International Society for Cellular Therapy. Published by Elsevier Inc. All rights reserved.
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Energy Technology Data Exchange (ETDEWEB)
Bernholdt, D E; McInnes, L C; Govindaraju, M; Bramley, R; Epperly, T; Kohl, J A; Nieplocha, J; Armstrong, R; Shasharina, S; Sussman, A L; Sottile, M; Damevski, K
2009-04-14
A resounding success of the Scientific Discovery through Advanced Computing (SciDAC) program is that high-performance computational science is now universally recognized as a critical aspect of scientific discovery [71], complementing both theoretical and experimental research. As scientific communities prepare to exploit unprecedented computing capabilities of emerging leadership-class machines for multi-model simulations at the extreme scale [72], it is more important than ever to address the technical and social challenges of geographically distributed teams that combine expertise in domain science, applied mathematics, and computer science to build robust and flexible codes that can incorporate changes over time. The Center for Technology for Advanced Scientific Component Software (TASCS) tackles these issues by exploiting component-based software development to facilitate collaborative high-performance scientific computing.
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Kim, Mijung
This study began with questions about how science education can bring forth humanity and ethics to reflect increasing concerns about controversial issues of science and technology in contemporary society. Discussing and highlighting binary epistemological assumptions in science education, the study suggests embodied science learning with human subjectivity and integrity between knowledge and practice. The study questions (a) students' understandings of the relationships between STSE and their everyday lifeworld and (b) the challenges of cultivating scientific literacy through STSE teaching. In seeking to understand something about the pedagogical enactment of embodied scientific literacy that emphasizes the harmony of children's knowledges and their lifeworlds, this study employs a mindful pedagogy of hermeneutics. The intro- and intra-dialogical modes of hermeneutic understanding investigate the pedagogical relationship of parts (research texts of students, curriculum, and social milieu) and the whole (STSE teaching in contemporary time and place). The research was conducted with 86 Korean 6 graders at a public school in Seoul, Korea in 2003. Mixed methods were utilized for data collection including a survey questionnaire, a drawing activity, interviews, children's reflective writing, and classroom teaching and observation. The research findings suggest the challenges and possibilities of STSE teaching as follows: (a) children's separated knowledge from everyday practice and living, (b) children's conflicting ideas between ecological/ethical aspects and modernist values, (c) possibilities of embodied knowing in children's practice, and (d) teachers' pedagogical dilemmas in STSE teaching based on the researcher's experiences and reflection throughout teaching practice. As further discussion, this study suggests an ecological paradigm for science curriculum and teaching as a potential framework to cultivate participatory scientific literacy for citizenship in
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Energy Technology Data Exchange (ETDEWEB)
Becker, Kurt H.; McCurdy, C. William; Orlando, Thomas M.; Rescigno, Thomas N.
2000-09-01
This report is based largely on presentations and discussions at two workshops and contributions from workshop participants. The workshop on Fundamental Challenges in Electron-Driven Chemistry was held in Berkeley, October 9-10, 1998, and addressed questions regarding theory, computation, and simulation. The workshop on Electron-Driven Processes: Scientific Challenges and Technological Opportunities was held at Stevens Institute of Technology, March 16-17, 2000, and focused largely on experiments. Electron-molecule and electron-atom collisions initiate and drive almost all the relevant chemical processes associated with radiation chemistry, environmental chemistry, stability of waste repositories, plasma-enhanced chemical vapor deposition, plasma processing of materials for microelectronic devices and other applications, and novel light sources for research purposes (e.g. excimer lamps in the extreme ultraviolet) and in everyday lighting applications. The life sciences are a rapidly advancing field where the important role of electron-driven processes is only now beginning to be recognized. Many of the applications of electron-initiated chemical processes require results in the near term. A large-scale, multidisciplinary and collaborative effort should be mounted to solve these problems in a timely way so that their solution will have the needed impact on the urgent questions of understanding the physico-chemical processes initiated and driven by electron interactions.
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XVis: Visualization for the Extreme-Scale Scientific-Computation Ecosystem: Year-end report FY15 Q4.
Energy Technology Data Exchange (ETDEWEB)
Moreland, Kenneth D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Sewell, Christopher [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Childs, Hank [Univ. of Oregon, Eugene, OR (United States); Ma, Kwan-Liu [Univ. of California, Davis, CA (United States); Geveci, Berk [Kitware, Inc., Clifton Park, NY (United States); Meredith, Jeremy [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)
2015-12-01
The XVis project brings together the key elements of research to enable scientific discovery at extreme scale. Scientific computing will no longer be purely about how fast computations can be performed. Energy constraints, processor changes, and I/O limitations necessitate significant changes in both the software applications used in scientific computation and the ways in which scientists use them. Components for modeling, simulation, analysis, and visualization must work together in a computational ecosystem, rather than working independently as they have in the past. This project provides the necessary research and infrastructure for scientific discovery in this new computational ecosystem by addressing four interlocking challenges: emerging processor technology, in situ integration, usability, and proxy analysis.
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XVis: Visualization for the Extreme-Scale Scientific-Computation Ecosystem: Mid-year report FY17 Q2
Energy Technology Data Exchange (ETDEWEB)
Moreland, Kenneth D. [Sandia National Lab. (SNL-NM), Albuquerque, NM (United States); Pugmire, David [Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States); Rogers, David [Los Alamos National Lab. (LANL), Los Alamos, NM (United States); Childs, Hank [Univ. of Oregon, Eugene, OR (United States); Ma, Kwan-Liu [Univ. of California, Davis, CA (United States); Geveci, Berk [Kitware Inc., Clifton Park, NY (United States)
2017-05-01
The XVis project brings together the key elements of research to enable scientific discovery at extreme scale. Scientific computing will no longer be purely about how fast computations can be performed. Energy constraints, processor changes, and I/O limitations necessitate significant changes in both the software applications used in scientific computation and the ways in which scientists use them. Components for modeling, simulation, analysis, and visualization must work together in a computational ecosystem, rather than working independently as they have in the past. This project provides the necessary research and infrastructure for scientific discovery in this new computational ecosystem by addressing four interlocking challenges: emerging processor technology, in situ integration, usability, and proxy analysis.
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XVis: Visualization for the Extreme-Scale Scientific-Computation Ecosystem. Mid-year report FY16 Q2
Energy Technology Data Exchange (ETDEWEB)
Moreland, Kenneth D.; Sewell, Christopher (LANL); Childs, Hank (U of Oregon); Ma, Kwan-Liu (UC Davis); Geveci, Berk (Kitware); Meredith, Jeremy (ORNL)
2016-05-01
The XVis project brings together the key elements of research to enable scientific discovery at extreme scale. Scientific computing will no longer be purely about how fast computations can be performed. Energy constraints, processor changes, and I/O limitations necessitate significant changes in both the software applications used in scientific computation and the ways in which scientists use them. Components for modeling, simulation, analysis, and visualization must work together in a computational ecosystem, rather than working independently as they have in the past. This project provides the necessary research and infrastructure for scientific discovery in this new computational ecosystem by addressing four interlocking challenges: emerging processor technology, in situ integration, usability, and proxy analysis.
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Zudilova-Seinstra, E.V.
2007-01-01
A scientific problem solving environment should be built in such a way that users (scientists) might exploit underlying technologies without a specialised knowledge about available tools and resources. An adaptive user interface can be considered as an opportunity in addressing this challenge. This
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Accelerating scientific discovery : 2007 annual report.
Energy Technology Data Exchange (ETDEWEB)
Beckman, P.; Dave, P.; Drugan, C.
2008-11-14
As a gateway for scientific discovery, the Argonne Leadership Computing Facility (ALCF) works hand in hand with the world's best computational scientists to advance research in a diverse span of scientific domains, ranging from chemistry, applied mathematics, and materials science to engineering physics and life sciences. Sponsored by the U.S. Department of Energy's (DOE) Office of Science, researchers are using the IBM Blue Gene/L supercomputer at the ALCF to study and explore key scientific problems that underlie important challenges facing our society. For instance, a research team at the University of California-San Diego/ SDSC is studying the molecular basis of Parkinson's disease. The researchers plan to use the knowledge they gain to discover new drugs to treat the disease and to identify risk factors for other diseases that are equally prevalent. Likewise, scientists from Pratt & Whitney are using the Blue Gene to understand the complex processes within aircraft engines. Expanding our understanding of jet engine combustors is the secret to improved fuel efficiency and reduced emissions. Lessons learned from the scientific simulations of jet engine combustors have already led Pratt & Whitney to newer designs with unprecedented reductions in emissions, noise, and cost of ownership. ALCF staff members provide in-depth expertise and assistance to those using the Blue Gene/L and optimizing user applications. Both the Catalyst and Applications Performance Engineering and Data Analytics (APEDA) teams support the users projects. In addition to working with scientists running experiments on the Blue Gene/L, we have become a nexus for the broader global community. In partnership with the Mathematics and Computer Science Division at Argonne National Laboratory, we have created an environment where the world's most challenging computational science problems can be addressed. Our expertise in high-end scientific computing enables us to provide
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Human brain MRI at 500 MHz, scientific perspectives and technological challenges
Le Bihan, Denis; Schild, Thierry
2017-03-01
The understanding of the human brain is one of the main scientific challenges of the 21st century. In the early 2000s the French Alternative Energies and Atomic Energy Commission launched a program to conceive and build a ‘human brain explorer’, the first human MRI scanner operating at 11.7 T. This scanner was envisioned to be part of the ambitious French-German project Iseult, bridging together industrial and academic partners to push the limits of molecular neuroimaging, from mouse to man, using ultra-high field MRI. In this article we provide a summary of the main neuroscience and medical targets of the Iseult project, mainly to acquire within timescales compatible with human tolerances images at a scale of 100 μm at which everything remains to discover, and to create new approaches to develop new imaging biomarkers for specific neurological and psychiatric disorders. The system specifications, the technological challenges, in terms of magnet design, winding technology, cryogenics, quench protection, stability control, and the solutions which have been chosen to overcome them and build this outstanding instrument are provided. Lines of the research and development which will be necessary to fully exploit the potential of this and other UHF MRI scanners are also outlined.
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PUBLICATION OF SCIENTIFIC PERIODICALS AT UNIVERSITIES:NEW CHALLENGES, PARTICIPANTS TECHNOLOGY
Directory of Open Access Journals (Sweden)
T. О. Kolesnykova
2015-11-01
Full Text Available Purpose. Publication of scientific periodicals in the Universities is very important and necessary element in the infrastructure of scientific communication. The aim of the article is: 1 providing a new model of publication system of the University scientific periodicals (on the example of Dnipropetrovsk National University of Railway Transport named after Academician V. Lazaryan – DNURT; 2 studying the peculiarities of the «Library publishing» model (Library Publishing and library as a new participant in the publication of world scientific periodicals of the University; 3 description of the developed software automation typesetting of scientific articles and their integration into international databases of scientific and technical information. Methodology. The scientists investigated: 1 the system of publication of scientific periodicals at DNURT; 2 integration system of electronic versions of periodicals and individual articles of scientists from DNURT into the world scientific databases; 3 publishing activity of the scientific and technical library of the University. Findings. The authors proved the need for the fast updates in each higher education institution of Ukrainian management system of scientific periodicals and the creation of the periodicals development concept. The conditions for the occurrence of positive changes in the publishing process in Universities were determined and named as a new participant in these processes – University library. The list of new tasks inherent in the scientific periodicals of the Universities was presented. The software product «Digital designer» was created as a new applied information technology solution to extend the functionality of the basic system information of the publication according to its editorial policy. Originality. The scientists studied the transformation process of the organizational structure of scientific periodicals publishing in the Universities of Ukraine and the world
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Energy Technology Data Exchange (ETDEWEB)
Bunn, Amoret L.; Wellman, Dawn M.; Deeb, Rula A.; Hawley, Elizabeth L.; Truex, Michael J.; Peterson, Mark; Freshley, Mark D.; Pierce, Eric M.; McCord, John; Young, Michael H.; Gilmore, Tyler J.; Miller, Rick; Miracle, Ann L.; Kaback, Dawn; Eddy-Dilek, Carol; Rossabi, Joe; Lee, Michelle H.; Bush, Richard P.; Beam , Paul; Chamberlain, G. M.; Marble, Justin; Whitehurst, Latrincy; Gerdes, Kurt D.; Collazo, Yvette
2012-05-15
Through an inter-disciplinary effort, DOE is addressing a need to advance monitoring approaches from sole reliance on cost- and labor-intensive point-source monitoring to integrated systems-based approaches such as flux-based approaches and the use of early indicator parameters. Key objectives include identifying current scientific, technical and implementation opportunities and challenges, prioritizing science and technology strategies to meet current needs within the DOE complex for the most challenging environments, and developing an integrated and risk-informed monitoring framework.
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Bosomworth, Karyn; Owen, Christine; Curnin, Steven
2017-04-01
The mounting frequency and intensity of natural hazards, alongside growing interdependencies between social-technical and ecological systems, are placing increased pressure on emergency management. This is particularly true at the strategic level of emergency management, which involves planning for and managing non-routine, high-consequence events. Drawing on the literature, a survey, and interviews and workshops with Australia's senior emergency managers, this paper presents an analysis of five core challenges that these pressures are creating for strategic-level emergency management. It argues that emphasising 'emergency management' as a primary adaptation strategy is a retrograde step that ignores the importance of addressing socio-political drivers of vulnerabilities. Three key suggestions are presented that could assist the country's strategic-level emergency management in tackling these challenges: (i) reframe emergency management as a component of disaster risk reduction rather than them being one and the same; (ii) adopt a network governance approach; and (iii) further develop the capacities of strategic-level emergency managers. © 2017 The Author(s). Disasters © Overseas Development Institute, 2017.
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International Nuclear Information System (INIS)
Nam, H; Stoitsov, M; Nazarewicz, W; Hagen, G; Kortelainen, M; Pei, J C; Bulgac, A; Maris, P; Vary, J P; Roche, K J; Schunck, N; Thompson, I; Wild, S M
2012-01-01
The demands of cutting-edge science are driving the need for larger and faster computing resources. With the rapidly growing scale of computing systems and the prospect of technologically disruptive architectures to meet these needs, scientists face the challenge of effectively using complex computational resources to advance scientific discovery. Multi-disciplinary collaborating networks of researchers with diverse scientific backgrounds are needed to address these complex challenges. The UNEDF SciDAC collaboration of nuclear theorists, applied mathematicians, and computer scientists is developing a comprehensive description of nuclei and their reactions that delivers maximum predictive power with quantified uncertainties. This paper describes UNEDF and identifies attributes that classify it as a successful computational collaboration. We illustrate significant milestones accomplished by UNEDF through integrative solutions using the most reliable theoretical approaches, most advanced algorithms, and leadership-class computational resources.
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Addressing complex challenges using a co-innovation approach
Vereijssen, Jessica; Srinivasan, M.S.; Dirks, Sarah; Fielke, Simon; Jongmans, C.T.; Agnew, Natasha; Klerkx, Laurens; Pinxterhuis, Ina; Moore, John; Edwards, Paul; Brazendale, Rob; Botha, Neels; Turner, James A.
2017-01-01
Co-innovation can be effective for complex challenges – involving interactions amongst multiple stakeholders, viewpoints, perceptions, practices and interests across programmes, sectors and national systems. Approaches to challenges in the primary sector have tended to be linear, where tools and
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submitter CERN openlab white paper on future ICT challenges in scientific research
Di Meglio, Alberto; Purcell, Andrew; Rademakers, Fons
Throughout its 16-year history, CERN openlab has worked to develop and test new ICT technologies and techniques that help to make the ground-breaking physics discoveries at CERN possible. CERN openlab runs in three-year phases, with around 20 projects — addressing a wide range of IT topics — being run in its current, fifth phase. With CERN openlab’s sixth three-year phase set to begin at the start of 2018, work has been carried out throughout the first half of 2017 to identify key areas for future collaboration. A series of workshops and discussions was held to discuss the ICT challenges faced by the LHC research community — and other ‘big science’ projects over the coming years. This white paper is the culmination of these investigations, and sets out specific challenges that are ripe for tackling through collaborative R&D; projects.
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Turrin, M.; Kenna, T. C.
2014-12-01
The new NGSS provide an important opportunity for scientists to develop curriculum that links the practice of science to research-based data in order to improve understanding in areas of science that are both complex and confusing. Our curriculum focuses in particular on the fate and transport of anthropogenic radionuclides. Radioactivity, both naturally occurring and anthropogenic, is highly debated and largely misunderstood, and for large sections of the population is a source of scientific misunderstanding. Developed as part of the international GEOTRACES project which focuses on identifying ocean processes and quantifying fluxes that control the distributions of selected trace elements and isotopes in the ocean, and on establishing the sensitivity of these distributions to changing environmental conditions, the curriculum topic fits nicely into the applied focus of NGSS with both environmental and topical relevance. Our curriculum design focuses on small group discussion driven by questions, yet unlike more traditional curriculum pieces these are not questions posed to the students, rather they are questions posed by the students to facilitate their deeper understanding. Our curriculum design challenges the traditional question/answer memorization approach to instruction as we strive to develop an educational approach that supports the practice of science as well as the NGSS Cross Cutting Concepts and the Science & Engineering Practices. Our goal is for students to develop a methodology they can employ when faced with a complex scientific issue. Through background readings and team discussions they identify what type of information is important for them to know and where to find a reliable source for that information. Framing their discovery around key questions such as "What type of radioactive decay are we dealing with?", "What is the potential half-life of the isotope?", and "What are the pathways of transport of radioactivity?" allows students to evaluate a
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Online Learning: Addressing Challenges and Seizing Opportunities. Hawaii
Alliance for Excellent Education, 2010
2010-01-01
America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…
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Addressing the Challenges of Hepatitis C Virus Resistance and Treatment Failure
Directory of Open Access Journals (Sweden)
Che C. Colpitts
2016-08-01
Full Text Available Chronic hepatitis C is a major cause of chronic liver disease, including liver cirrhosis and hepatocellular carcinoma. The development of direct-acting antivirals (DAAs revolutionized hepatitis C virus (HCV treatment by offering genuine prospects for the first comprehensive cure of a chronic viral infection in humans. While antiviral resistance is a significant limitation for interferon-based therapies, resistance and treatment failure still appear to be present in a small fraction of patients even in state-of-the-art DAA combination therapies. Therefore, treatment failure and resistance still remain a clinical challenge for the management of patients not responding to DAAs. In this special issue of Viruses on HCV drug resistance, mechanisms of antiviral resistance for different classes of antiviral drugs are described. Furthermore, the detection and monitoring of resistance in clinical practice, the clinical impact of resistance in different patient groups and strategies to prevent and address resistance and treatment failure using complementary antiviral strategies are reviewed.
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Addressing the Challenges of Hepatitis C Virus Resistance and Treatment Failure.
Colpitts, Che C; Baumert, Thomas F
2016-08-16
Chronic hepatitis C is a major cause of chronic liver disease, including liver cirrhosis and hepatocellular carcinoma. The development of direct-acting antivirals (DAAs) revolutionized hepatitis C virus (HCV) treatment by offering genuine prospects for the first comprehensive cure of a chronic viral infection in humans. While antiviral resistance is a significant limitation for interferon-based therapies, resistance and treatment failure still appear to be present in a small fraction of patients even in state-of-the-art DAA combination therapies. Therefore, treatment failure and resistance still remain a clinical challenge for the management of patients not responding to DAAs. In this special issue of Viruses on HCV drug resistance, mechanisms of antiviral resistance for different classes of antiviral drugs are described. Furthermore, the detection and monitoring of resistance in clinical practice, the clinical impact of resistance in different patient groups and strategies to prevent and address resistance and treatment failure using complementary antiviral strategies are reviewed.
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Biodiversity data provision and decision-making - addressing the challenges
Directory of Open Access Journals (Sweden)
Katherine Despot-Belmonte
2017-02-01
Full Text Available Essential Biodiversity Variables (EBVs are measurements required for study, reporting, and management of biodiversity change. They are being developed to support consistency, from the collection to the reporting of biodiversity data at the national, regional and global scales. However, "EBV stakeholders" need to strike a balance between 'doing innovative research' and 'having positive impact' on biodiversity management decisions. This paper reports on a workshop entitled Identifying joint pathways to address the challenges of biodiversity data provision and decision-making and presents the main workshop’s output, a “researcher’s brief” entitled Guiding principles for promoting the application of EBVs for current and future needs of decision-makers. These guiding principles are: Speak with a common voice; Clearly define what is an EBV and how it relates to indicators; Engage beyond the research world; Be realistic about what can be done now and later; Define criteria for good EBVs; Use EBV as a clearing house; Convey the limitations of EBVs; Clarify what impact EBVs should have; Be salient, credible, legitimate, iterative; Don't put an EBV skin on everything you do; Don't create too many EBVs; and Don't reduce EBVs to building blocks of indicators. This brief is of relevance to the wider GEO BON (Group on Earth Observation Biodoversity Observation Network community, and in particular those scientists/researchers interested in the application of EBVs.
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Coach strategies for addressing psychosocial challenges during the return to sport from injury.
Podlog, Leslie; Dionigi, Rylee
2010-09-01
The purpose of this study was to examine coach strategies for addressing athletes' psychosocial challenges in returning to sport following injury rehabilitation. Qualitative interviews with eight elite coaches from the Western Australian Institute of Sport (WAIS) in Perth, Australia revealed that coaches facilitated athletes' return to sport from injury through a variety of means, but did not typically provide systematic forms of assistance. Coaches commented that the idiosyncratic nature of the injury experience meant that they needed to apply strategies consistent with athletes' particular psychosocial needs. Such strategies included: (a) coordination of a "team approach" to rehabilitation; (b) fostering open communication with athletes and treatment team members; (c) social support; (d) positive thinking and goal setting; and (e) role models. Analysis of these strategies revealed that coaches attempted to address competence, autonomy, and relatedness needs in facilitating athletes' return from injury. These findings suggest that self-determination theory may be a valuable approach for examining coach forms of assistance regarding athletes' return to competition following injury. Findings are discussed in relation to injury literature and self-determination theory. Suggestions for future research are also presented.
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Ra, Sungsup; Chin, Brian; Lim, Cher Ping
2016-01-01
Information and Communication Technology (ICT) offers opportunities for governments to address key education challenges of quality, equity, and efficiency. While governments and educational institutions in developed countries may have taken up these opportunities, many developing countries in Asia and the Pacific region have often missed them out.…
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Test Driven Development of Scientific Models
Clune, Thomas L.
2014-01-01
Test-Driven Development (TDD), a software development process that promises many advantages for developer productivity and software reliability, has become widely accepted among professional software engineers. As the name suggests, TDD practitioners alternate between writing short automated tests and producing code that passes those tests. Although this overly simplified description will undoubtedly sound prohibitively burdensome to many uninitiated developers, the advent of powerful unit-testing frameworks greatly reduces the effort required to produce and routinely execute suites of tests. By testimony, many developers find TDD to be addicting after only a few days of exposure, and find it unthinkable to return to previous practices.After a brief overview of the TDD process and my experience in applying the methodology for development activities at Goddard, I will delve more deeply into some of the challenges that are posed by numerical and scientific software as well as tools and implementation approaches that should address those challenges.
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AMRZone: A Runtime AMR Data Sharing Framework For Scientific Applications
Energy Technology Data Exchange (ETDEWEB)
Zhang, Wenzhao; Tang, Houjun; Harenberg, Steven; Byna, Suren; Zou, Xiaocheng; Devendran, Dharshi; Martin, Daniel; Wu, Kesheng; Dong, Bin; Klasky, Scott; Samatova, Nagiza
2017-08-31
Frameworks that facilitate runtime data sharing across multiple applications are of great importance for scientific data analytics. Although existing frameworks work well over uniform mesh data, they can not effectively handle adaptive mesh refinement (AMR) data. Among the challenges to construct an AMR-capable framework include: (1) designing an architecture that facilitates online AMR data management; (2) achieving a load-balanced AMR data distribution for the data staging space at runtime; and (3) building an effective online index to support the unique spatial data retrieval requirements for AMR data. Towards addressing these challenges to support runtime AMR data sharing across scientific applications, we present the AMRZone framework. Experiments over real-world AMR datasets demonstrate AMRZone's effectiveness at achieving a balanced workload distribution, reading/writing large-scale datasets with thousands of parallel processes, and satisfying queries with spatial constraints. Moreover, AMRZone's performance and scalability are even comparable with existing state-of-the-art work when tested over uniform mesh data with up to 16384 cores; in the best case, our framework achieves a 46% performance improvement.
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BIG DATA-Related Challenges and Opportunities in Earth System Modeling
Bamzai, A. S.
2012-12-01
Knowledge of the Earth's climate has increased immensely in recent decades, both through observational analysis and modeling. BIG DATA-related challenges emerge in our quest for understanding the variability and predictability of the climate and earth system on a range of time scales, as well as in our endeavor to improve predictive capability using state-of-the-science models. To enable further scientific discovery, bottlenecks in current paradigms need to be addressed. An overview of current NSF activities in Earth System Modeling with a focus on associated data-related challenges and opportunities, will be presented.
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Energy Technology Data Exchange (ETDEWEB)
Zoback, M.D.
1998-08-30
The fundamental scientific issue addressed in this proposal, obtaining an improved understanding of the physical and chemical processes responsible for earthquakes along major fault zones, is clearly of global scientific interest. By sampling the San Andreas fault zone and making direct measurements of fault zone properties to 4.0 km at Parkfield they will be studying an active plate-boundary fault at a depth where aseismic creep and small earthquakes occur and where a number of the scientific questions associated with deeper fault zone drilling can begin to be addressed. Also, the technological challenges associated with drilling, coring, downhole measurements and borehole instrumentation that may eventually have to be faced in deeper drilling can first be addressed at moderate depth and temperature in the Parkfield hole. Throughout the planning process leading to the development of this proposal they have invited participation by scientists from around the world. As a result, the workshops and meetings they have held for this project have involved about 350 scientists and engineers from about a dozen countries.
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Sheets, Rebecca L; Zhou, TieQun; Knezevic, Ivana
2016-03-01
Clinical development of prophylactic HIV/AIDS vaccines presents many scientific challenges that result in challenges for regulators reviewing clinical trial applications (CTAs). The World Health Organization (WHO) has the responsibility to provide technical support to these regulators. The search for an HIV/AIDS vaccine will only succeed through well-designed, -conducted and -controlled human efficacy studies reviewed and approved by regulators in countries worldwide, particularly in countries where the epidemic has hit hardest, such as in sub-Saharan Africa and Asia. This review summarizes the current candidates in development and focuses on challenges regulators face when reviewing CTAs, such as the evolving landscape of "standard of prevention," trials in adolescents, adaptive trial designs, correlates of protection and their analysis, and access to successful vaccines. There are many unknowns in the field of HIV/AIDS vaccine development and often, there is not a clear right or wrong approach because of the scientific challenges described in this review. Consequently, regulators should not feel that decisions need be made in isolation, when there are many available international collaborative efforts and opportunities to seek expert advice. The WHO provides many such opportunities and support to regulators across the globe. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.
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Computing in research and development in Africa benefits, trends, challenges and solutions
2015-01-01
This book describes the trends, challenges and solutions in computing use for scientific research and development within different domains in Africa, such as health, agriculture, environment, economy, energy, education and engineering. The benefits expected are discussed by a number of recognized, domain-specific experts, with a common theme being computing as solution enabler. This book is the first document providing such a representative up-to-date view on this topic at the continent level. • Discusses computing for scientific research and development on the African continent, addressing domains such as engineering, health, agriculture, environment, economy, energy, and education; • Describes the state-of-the-art in usage of computing to address problems in developing countries pertaining to health, productivity, economic growth, and renewable energy; • Offers insights applicable to all developing countries on the use of computing technologies to address a variety of societal issues.
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Ranking scientific publications: the effect of nonlinearity
Yao, Liyang; Wei, Tian; Zeng, An; Fan, Ying; di, Zengru
2014-10-01
Ranking the significance of scientific publications is a long-standing challenge. The network-based analysis is a natural and common approach for evaluating the scientific credit of papers. Although the number of citations has been widely used as a metric to rank papers, recently some iterative processes such as the well-known PageRank algorithm have been applied to the citation networks to address this problem. In this paper, we introduce nonlinearity to the PageRank algorithm when aggregating resources from different nodes to further enhance the effect of important papers. The validation of our method is performed on the data of American Physical Society (APS) journals. The results indicate that the nonlinearity improves the performance of the PageRank algorithm in terms of ranking effectiveness, as well as robustness against malicious manipulations. Although the nonlinearity analysis is based on the PageRank algorithm, it can be easily extended to other iterative ranking algorithms and similar improvements are expected.
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Ranking scientific publications: the effect of nonlinearity.
Yao, Liyang; Wei, Tian; Zeng, An; Fan, Ying; Di, Zengru
2014-10-17
Ranking the significance of scientific publications is a long-standing challenge. The network-based analysis is a natural and common approach for evaluating the scientific credit of papers. Although the number of citations has been widely used as a metric to rank papers, recently some iterative processes such as the well-known PageRank algorithm have been applied to the citation networks to address this problem. In this paper, we introduce nonlinearity to the PageRank algorithm when aggregating resources from different nodes to further enhance the effect of important papers. The validation of our method is performed on the data of American Physical Society (APS) journals. The results indicate that the nonlinearity improves the performance of the PageRank algorithm in terms of ranking effectiveness, as well as robustness against malicious manipulations. Although the nonlinearity analysis is based on the PageRank algorithm, it can be easily extended to other iterative ranking algorithms and similar improvements are expected.
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Lu, Yonglong; Jenkins, Alan; Ferrier, Robert C; Bailey, Mark; Gordon, Iain J; Song, Shuai; Huang, Jikun; Jia, Shaofeng; Zhang, Fusuo; Liu, Xuejun; Feng, Zhaozhong; Zhang, Zhibin
2015-02-01
China's increasingly urbanized and wealthy population is driving a growing and changing demand for food, which might not be met without significant increase in agricultural productivity and sustainable use of natural resources. Given the past relationship between lack of access to affordable food and political instability, food security has to be given a high priority on national political agendas in the context of globalization. The drive for increased food production has had a significant impact on the environment, and the deterioration in ecosystem quality due to historic and current levels of pollution will potentially compromise the food production system in China. We discuss the grand challenges of not only producing more food but also producing it sustainably and without environmental degradation. In addressing these challenges, food production should be considered as part of an environmental system (soil, air, water, and biodiversity) and not independent from it. It is imperative that new ways of meeting the demand for food are developed while safeguarding the natural resources upon which food production is based. We present a holistic approach to both science and policy to ensure future food security while embracing the ambition of achieving environmental sustainability in China. It is a unique opportunity for China to be a role model as a new global player, especially for other emerging economies.
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Challenging structures through addressing gender-based violence
African Journals Online (AJOL)
Getting the past right in West Africa and beyond: Addressing gender-based ... 2 See Convention on the Elimination of All Forms of Discrimination against Women .... 6 The Protocol to the African Charter on Human and People's Rights on the ...
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Scientific issues and emerging challenges for radiological protection
International Nuclear Information System (INIS)
2007-01-01
Scientific knowledge is constantly evolving as more advanced technologies become available and more in-depth research is carried out. Given the potential implications that new findings could have on policy decisions, in 1998 the NEA Committee on Radiation Protection and Public Health (CRPPH) performed a survey of state-of-the-art research in radiological protection science. This study suggested that, while the current system of radiological protection was well under-pinned by scientific understanding, growing knowledge in several areas could seriously impact policy and regulation. Ten years later, the CRPPH has again performed a survey of state-of-the-art research which reiterates and clarifies its earlier conclusions. This report summarises the results of this latest CRPPH assessment of radiological protection science. Specifically, it explains that knowledge of non-targeted and delayed effects, as well as of individual sensitivity, have been significantly refined over the past ten years. Although at this point there is still no scientific certainty in these areas, based on the most recent studies and results, the report strongly suggests that policy makers and regulatory authorities should consider possible impacts that could arise from research in the next few years. Further, the report identifies research areas that should be supported to more definitively answer scientific questions having the most direct impacts on policy choices. (author)
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Sustainable Nutrient Management in Chinese Agriculture:Challenges and Perspective
Institute of Scientific and Technical Information of China (English)
无
2006-01-01
China has to raise agricultural productivity in its limited and shrinking farmland to guarantee food security for its huge and ever-growing population. Sustainable soil nutrient management is of paramount importance to the world's most populous country. Critical challenges the country is facing in sustaining soil fertility and in alleviating the hazardous impact of intensive fertilizer use are discussed in this paper. It is emphatically pointed out that national strategies as well as area-specific action plans with respect to scientific nutrient management are urgently needed to balance productivity and sustainability in the future. Relevant proposals for addressing those challenges are also presented.
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Communicating with scientific graphics: A descriptive inquiry into non-ideal normativity.
Sheredos, Benjamin
2017-06-01
Scientists' graphical practices have recently become a target of inquiry in the philosophy of science, and in the cognitive sciences. Here I supplement our understanding of graphical practices via a case study of how researchers crafted the graphics for scientific publication in the field of circadian biology. The case highlights social aspects of graphical production which have gone understudied - especially concerning the negotiation of publication. I argue that it also supports a challenge to the claim that empirically-informed "cognitive design principles" offer an apt understanding of the norms of success which govern good scientific graphic design to communicate data and hypotheses to other experts. In this respect, the case-study also illustrates how "descriptive" studies of scientific practice can connect with normative issues in philosophy of science, thereby addressing a central concern in recent discussions of practice-oriented philosophy of science. Copyright © 2017 Elsevier Ltd. All rights reserved.
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Johnston, Lee M; Finegood, Diane T
2015-03-18
Over the past few decades, cross-sector partnerships with the private sector have become an increasingly accepted practice in public health, particularly in efforts to address infectious diseases in low- and middle-income countries. Now these partnerships are becoming a popular tool in efforts to reduce and prevent obesity and the epidemic of noncommunicable diseases. Partnering with businesses presents a means to acquire resources, as well as opportunities to influence the private sector toward more healthful practices. Yet even though collaboration is a core principle of public health practice, public-private or nonprofit-private partnerships present risks and challenges that warrant specific consideration. In this article, we review the role of public health partnerships with the private sector, with a focus on efforts to address obesity and noncommunicable diseases in high-income settings. We identify key challenges-including goal alignment and conflict of interest-and consider how changes to partnership practice might address these.
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The challenge of increasing scientific and technological manpower in Thailand
Kulintornprasert, Usanee
Scope and method of study. The purpose of this study is to examine the responses of Thai educators and other stakeholders in each organization. They are facing the challenge of increasing scientific and technological manpower for the future of scientific and technological capabilities in Thailand. A dramaturgy analysis procedure serves as the framework for the study. This framework provides a tool to help comprehend, describe, communicate, and transform the character and process of the remedy of the S&T manpower shortage. Namely, Burke's five elements are useful in this process. The scene is the setting of the performance, which refers to the current situation of Thailand's science and technology capability. The act displays various problems that take place in the setting. The agent means the groups of people who are involved in the S&T manpower development process and their roles to accelerate S&T manpower development strategies. The agency describes the projects that support those strategies, and the purpose is the reason or motive for the above-mentioned strategies. Findings and conclusions. Through the dramaturgical analysis on the basis of data collection, the conclusions of this study can be shown as the following items. First, the bureaucratic system is the barrier. As a result, the solution should be conducted both top-bottom and bottom-top performance. Second, the government should consider developing S&T strategies as a long-term plan. Third, the current science curricula should be revised. Fourth, universities should fully support and encourage faculty to conduct research along with teaching. Fifth, the quality of education should be improved. Sixth, "new blood" should be inserted in educational institutions. Last, but not least, the existing S&T curricula should be aimed at the international standard.
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A Disciplined Architectural Approach to Scaling Data Analysis for Massive, Scientific Data
Crichton, D. J.; Braverman, A. J.; Cinquini, L.; Turmon, M.; Lee, H.; Law, E.
2014-12-01
Data collections across remote sensing and ground-based instruments in astronomy, Earth science, and planetary science are outpacing scientists' ability to analyze them. Furthermore, the distribution, structure, and heterogeneity of the measurements themselves pose challenges that limit the scalability of data analysis using traditional approaches. Methods for developing science data processing pipelines, distribution of scientific datasets, and performing analysis will require innovative approaches that integrate cyber-infrastructure, algorithms, and data into more systematic approaches that can more efficiently compute and reduce data, particularly distributed data. This requires the integration of computer science, machine learning, statistics and domain expertise to identify scalable architectures for data analysis. The size of data returned from Earth Science observing satellites and the magnitude of data from climate model output, is predicted to grow into the tens of petabytes challenging current data analysis paradigms. This same kind of growth is present in astronomy and planetary science data. One of the major challenges in data science and related disciplines defining new approaches to scaling systems and analysis in order to increase scientific productivity and yield. Specific needs include: 1) identification of optimized system architectures for analyzing massive, distributed data sets; 2) algorithms for systematic analysis of massive data sets in distributed environments; and 3) the development of software infrastructures that are capable of performing massive, distributed data analysis across a comprehensive data science framework. NASA/JPL has begun an initiative in data science to address these challenges. Our goal is to evaluate how scientific productivity can be improved through optimized architectural topologies that identify how to deploy and manage the access, distribution, computation, and reduction of massive, distributed data, while
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OpenTopography: Addressing Big Data Challenges Using Cloud Computing, HPC, and Data Analytics
Crosby, C. J.; Nandigam, V.; Phan, M.; Youn, C.; Baru, C.; Arrowsmith, R.
2014-12-01
OpenTopography (OT) is a geoinformatics-based data facility initiated in 2009 for democratizing access to high-resolution topographic data, derived products, and tools. Hosted at the San Diego Supercomputer Center (SDSC), OT utilizes cyberinfrastructure, including large-scale data management, high-performance computing, and service-oriented architectures to provide efficient Web based access to large, high-resolution topographic datasets. OT collocates data with processing tools to enable users to quickly access custom data and derived products for their application. OT's ongoing R&D efforts aim to solve emerging technical challenges associated with exponential growth in data, higher order data products, as well as user base. Optimization of data management strategies can be informed by a comprehensive set of OT user access metrics that allows us to better understand usage patterns with respect to the data. By analyzing the spatiotemporal access patterns within the datasets, we can map areas of the data archive that are highly active (hot) versus the ones that are rarely accessed (cold). This enables us to architect a tiered storage environment consisting of high performance disk storage (SSD) for the hot areas and less expensive slower disk for the cold ones, thereby optimizing price to performance. From a compute perspective, OT is looking at cloud based solutions such as the Microsoft Azure platform to handle sudden increases in load. An OT virtual machine image in Microsoft's VM Depot can be invoked and deployed quickly in response to increased system demand. OT has also integrated SDSC HPC systems like the Gordon supercomputer into our infrastructure tier to enable compute intensive workloads like parallel computation of hydrologic routing on high resolution topography. This capability also allows OT to scale to HPC resources during high loads to meet user demand and provide more efficient processing. With a growing user base and maturing scientific user
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Data Management Challenges in a National Scientific Program of 55 Diverse Research Projects
De Bruin, T.
2016-12-01
In 2007-2015, the Dutch funding agency NWO funded the National Ocean and Coastal Research Program (in Dutch: ZKO). This program focused on `the scientific analysis of five societal challenges related to a sustainable use of the sea and coastal zones'. These five challenges were safety, economic yield, nature, spatial planning & development and water quality. The ZKO program was `set up to strengthen the cohesion and collaboration within Dutch marine research'. From the start of the program, data management was addressed, to allow data to be shared amongst the, diverse, research projects. The ZKO program was divided in 4 different themes (or regions). The `Carrying Capacity' theme was subdivided into 3 `research lines': Carrying capacity (Wadden Sea) - Policy-relevant Research - Monitoring - Hypothesis-driven Research Oceans North Sea Transnational Wadden Sea Research 56 Projects were funded, ranging from studies on the governance of the Wadden Sea to expeditions studying trace elements in the Atlantic Ocean. One of the first projects to be funded was the data management project. Its objectives were to allow data exchange between projects, to archive all relevant data from all ZKO projects and to make the data and publications publicly available, following the ZKO Data Policy. This project was carried out by the NIOZ Data Management Group. It turned out that the research projects had hardly any interest in sharing data between projects and had good (?) arguments not to share data at all until the end of the projects. A data portal was built, to host and make available all ZKO data and publications. When it came to submitting the data to this portal, most projects obliged willingly, though found it occasionally difficult to find time to do so. However, some projects refused to submit data to an open data portal, despite the rules set up by the funding agency and agreed by all. The take-home message of this presentation is that data sharing is a cultural and
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Fundamental Scientific Problems in Magnetic Recording
Energy Technology Data Exchange (ETDEWEB)
Schulthess, T.C.; Miller, M.K.
2007-06-27
Magnetic data storage technology is presently leading the high tech industry in advancing device integration--doubling the storage density every 12 months. To continue these advancements and to achieve terra bit per inch squared recording densities, new approaches to store and access data will be needed in about 3-5 years. In this project, collaboration between Oak Ridge National Laboratory (ORNL), Center for Materials for Information Technology (MINT) at University of Alabama (UA), Imago Scientific Instruments, and Seagate Technologies, was undertaken to address the fundamental scientific problems confronted by the industry in meeting the upcoming challenges. The areas that were the focus of this study were to: (1) develop atom probe tomography for atomic scale imaging of magnetic heterostructures used in magnetic data storage technology; (2) develop a first principles based tools for the study of exchange bias aimed at finding new anti-ferromagnetic materials to reduce the thickness of the pinning layer in the read head; (3) develop high moment magnetic materials and tools to study magnetic switching in nanostructures aimed at developing improved writers of high anisotropy magnetic storage media.
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Vuong, Thu; Nguyen, Nhu; Le, Giang; Shanahan, Marian; Ali, Robert; Ritter, Alison
2017-01-11
In Vietnam, like many countries in Southeast Asia, the commonly used approach of center-based compulsory drug treatment (CCT) has been criticized on human rights ground. Meanwhile, community-based voluntary methadone maintenance treatment (MMT) has been implemented for nearly a decade with promising results. Reform-minded leaders have been seeking empirical evidence of the costs and effectiveness associated with these two main treatment modalities. Conducting evaluations of these treatments, especially where randomization is not ethical, presents challenges. The aim of this paper is to discuss political challenges and methodological issues when conducting cost-effectiveness studies within the context of a non-democratic Southeast Asian country. A retrospective analysis of the political and scientific challenges that were experienced in the study design, sample size determination, government approval and ethics approvals, participant recruitment, data collection, and determination of sources, and quantification of cost and effectiveness data was undertaken. As a consequence of the non-randomized design, analysis of patient characteristics for both treatment types was undertaken to identify the magnitude of baseline group differences. Concordance between self-reported heroin use and urine drug testing was undertaken to determine the reliability of self-report data in a politically challenging environment. We demonstrate that conducting research around compulsory treatment in a non-democratic society is feasible, yet it is politically challenging and requires navigation between science and politics. We also demonstrate that engagement with the government decision makers in the research conception, implementation, and dissemination of the results increases the likelihood of research evidence being considered for change in a contentious drug policy area. Local empirical evidence on the comparative cost-effectiveness of CCT and MMT in a Southeast Asian setting is
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Newton, Alice; Borja, Angel; Solidoro, Cosimo; Grégoire, Marilaure
2015-10-01
The Marine Strategy Framework Directive (MSFD; EC, 2008) is an ambitious European policy instrument that aims to achieve Good Environmental Status (GES) in the 5,720,000 km2 of European seas by 2020, using an Ecosystem Approach. GES is to be assessed using 11 descriptors and up to 56 indicators (European Commission, 2010), and the goal is for clean, healthy and productive seas that are the basis for marine-based development, known as Blue-Growth. The MSFD is one of many policy instruments, such as the Water Framework Directive, the Common Fisheries Policy and the Habitats Directive that, together, should result in "Healthy Oceans and Productive Ecosystems - HOPE". Researchers working together with stakeholders such as the Member States environmental agencies, the European Environmental Agency, and the Regional Sea Conventions, are to provide the scientific knowledge basis for the implementation of the MSFD. This represents both a fascinating challenge and a stimulating opportunity.
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Scientific Visualization & Modeling for Earth Systems Science Education
Chaudhury, S. Raj; Rodriguez, Waldo J.
2003-01-01
Providing research experiences for undergraduate students in Earth Systems Science (ESS) poses several challenges at smaller academic institutions that might lack dedicated resources for this area of study. This paper describes the development of an innovative model that involves students with majors in diverse scientific disciplines in authentic ESS research. In studying global climate change, experts typically use scientific visualization techniques applied to remote sensing data collected by satellites. In particular, many problems related to environmental phenomena can be quantitatively addressed by investigations based on datasets related to the scientific endeavours such as the Earth Radiation Budget Experiment (ERBE). Working with data products stored at NASA's Distributed Active Archive Centers, visualization software specifically designed for students and an advanced, immersive Virtual Reality (VR) environment, students engage in guided research projects during a structured 6-week summer program. Over the 5-year span, this program has afforded the opportunity for students majoring in biology, chemistry, mathematics, computer science, physics, engineering and science education to work collaboratively in teams on research projects that emphasize the use of scientific visualization in studying the environment. Recently, a hands-on component has been added through science student partnerships with school-teachers in data collection and reporting for the GLOBE Program (GLobal Observations to Benefit the Environment).
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Science Teachers' Use of Mass Media to Address Socio-Scientific and Sustainability Issues
Klosterman, Michelle L.; Sadler, Troy D.; Brown, Julie
2012-01-01
The currency, relevancy and changing nature of science makes it a natural topic of focus for mass media outlets. Science teachers and students can capitalize on this wealth of scientific information to explore socio-scientific and sustainability issues; however, without a lens on how those media are created and how representations of science are…
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Scientific Drilling in the Arctic Ocean: A challenge for the next decades
Stein, R.; Coakley, B.
2009-04-01
Nansen Arctic Drilling Program as well as by sponsorships from British Petroleum, ConocoPhillips, ExxonMobil, Norwegian Petroleum Directorate, StatoilHydro, and Shell International. The major targets of the workshop were: (1) to bring together an international group of Arctic scientists, young scientists and ocean drilling scientists to learn and exchange ideas, experience and enthusiasm about the Arctic Ocean; (2) to develop a scientific drilling strategy to investigate the tectonic and paleoceanographic history of the Arctic Ocean and its role in influencing the global climate system; (3) to summarize the technical needs, opportunities, and limitations of drilling in the Arctic; (4) to define scientific and drilling targets for specific IODP-type campaigns in Arctic Ocean key areas to be finalized in the development of drilling proposals. Following overview presentations about the history of the Arctic Ocean, legacy of high-latitude ocean drilling, existing site-survey database, technical needs for high-latitude drilling, possibilities of collaboration with industry, and the process of developing ocean-drilling legs through IODP, the main part of the workshop was spent in thematic and regional break-out groups discussing the particular questions to be addressed by drilling and the particular targets for Arctic scientific drilling. Within the working groups, key scientific questions (related to the overall themes paleoceanography, tectonic evolution, petrology/geochemistry of basement, and gas hydrates) and strategies for reaching the overall goals were discussed and - as one of the main results - core groups for further developing drilling proposals were formed. Based on discussions at this workshop, approximately ten new pre-proposals are planned to be submitted to IODP for the April 01- 2009 deadline. We hope that the development of new scientific objectives through the pre-proposal process will help reshape plans for scientific ocean drilling beyond 2013 and direct
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Using Scientific Enquiry to Make Sense of Global Challenges
Hogg, Max
2010-01-01
In a context where the science underlying global issues such as climate change often loses out to political opinions and distortions, science teachers have a unique and very important role. Science teachers can use global-learning approaches to encourage learners to develop skills in scientific enquiry and critical analysis of scientific issues.…
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Hayati, Elli Nur; Emmelin, Maria; Eriksson, Malin
2014-01-01
Since the launch of a Zero Tolerance Policy in Indonesia, several policies to address domestic violence have been enacted. The obligation of local governments to establish service units for women survivors of domestic violence is one of them. Since domestic violence is a sensitive and complex issue in Indonesia it is important to understand how governmentally regulated services function in practice. This case study aimed to explore challenges faced by a local service agency in managing service provision for women survivors of domestic violence in rural Indonesia. Data from one focus group discussion (12 participants), four individual interviews, six short narratives, two days of participant observation, as well as archive reviews were collected. All data were analyzed using Grounded Theory Situational Analysis. The major challenge faced by the local agency was the low priority that was given them by the local authorities, mirrored also in low involvement by the assigned volunteers in the daily service. The study also identified a gap between the socio-cultural arena and the law & policy arena that needs to be bridged to avoid that the two arenas address domestic violence in a contradictory way. Budget allocation to support the sustainability of the daily routines of service agencies has to be given priority. There is also a need for careful considerations regarding the composition of personnel involved within daily management of service agencies addressing domestic violence. To bridge the gap between the legal systems and traditional cultural values, culturally adjusted alternative justice systems could be developed to increase women’s access to legal support. PMID:25363105
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Hecht, Alan D; Ferster, Aaron; Summers, Kevin
2017-10-16
When the U.S. Environmental Protection Agency (EPA) was established nearly 50 years ago, the nation faced serious threats to its air, land, and water, which in turn impacted human health. These threats were effectively addressed by the creation of EPA (in 1970) and many subsequent landmark environmental legislations which in turn significantly reduced threats to the Nation's environment and public health. A key element of historic legislation is research aimed at dealing with current and future problems. Today we face national and global challenges that go beyond classic media-specific (air, land, water) environmental legislation and require an integrated paradigm of action and engagement based on (1) innovation based on science and technology, (2) stakeholder engagement and collaboration, and (3) public education and support. This three-pronged approach recognizes that current environmental problems, include social as well as physical and environmental factors, are best addressed through collaborative problem solving, the application of innovation in science and technology, and multiple stakeholder engagement. To achieve that goal, EPA's Office of Research and Development (ORD) is working directly with states and local communities to develop and apply a suite of accessible decision support tools (DST) that aim to improve environmental conditions, protect human health, enhance economic opportunity, and advance a resilient and sustainability society. This paper showcases joint EPA and state actions to develop tools and approaches that not only meet current environmental and public health challenges, but do so in a way that advances sustainable, healthy, and resilient communities well into the future. EPA's future plans should build on current work but aim to effectively respond to growing external pressures. Growing pressures from megatrends are a major challenge for the new Administration and for cities and states across the country. The recent hurricanes hitting
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LENUS (Irish Health Repository)
Elmusharaf, Khalifa
2015-09-01
Universal health access will not be achieved unless women are cared for in their own communities and are empowered to take decisions about their own health in a supportive environment. This will only be achieved by community-based demand side interventions for maternal health access. In this review article, we highlight three common strategies to increase demand-side barriers to maternal healthcare access and identify the main challenges that still need to be addressed for these strategies to be effective.
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Energy Technology Data Exchange (ETDEWEB)
Nørskov, Jens [Stanford Univ., CA (United States);
; SLAC National Accelerator Lab., Menlo Park, CA (United States); Chen, Jingguang [Columbia Univ., New York, NY (United States); Brookhaven National Lab. (BNL), Upton, NY (United States); Miranda, Raul [Dept. of Energy (DOE), Washington DC (United States). Office of Science; Fitzsimmons, Tim [Dept. of Energy (DOE), Washington DC (United States). Office of Science; Stack, Robert [Dept. of Energy (DOE), Washington DC (United States). Office of Science 2016-02-18
Ammonia (NH3) is essential to all life on our planet. Until about 100 years ago, NH3 produced by reduction of dinitrogen (N2) in air came almost exclusively from bacteria containing the enzyme nitrogenase.. DOE convened a roundtable of experts on February 18, 2016. Participants in the Roundtable discussions concluded that the scientific basis for sustainable processes for ammonia synthesis is currently lacking, and it needs to be enhanced substantially before it can form the foundation for alternative processes. The Roundtable Panel identified an overarching grand challenge and several additional scientific grand challenges and research opportunities: -Discovery of active, selective, scalable, long-lived catalysts for sustainable ammonia synthesis. -Development of relatively low pressure (<10 atm) and relatively low temperature (<200 C) thermal processes. -Integration of knowledge from nature (enzyme catalysis), molecular/homogeneous and heterogeneous catalysis. -Development of electrochemical and photochemical routes for N2 reduction based on proton and electron transfer -Development of biochemical routes to N2 reduction -Development of chemical looping (solar thermochemical) approaches -Identification of descriptors of catalytic activity using a combination of theory and experiments -Characterization of surface adsorbates and catalyst structures (chemical, physical and electronic) under conditions relevant to ammonia synthesis.
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Managing a scarce resource: addressing critical health workforce challenges.
Giepmans. P.; Dussault, G.; Batenburg, R.; Frich, J.; Olivers, R.; Sermeus, W.
2013-01-01
With health care services significantly changing, the challenge is to initiate innovative, situational and integrated workforce forecasting and planning. Many health systems require a shift in mindset to move to the planning of skill mixes for health care professionals. This implies great challenges
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Hamburg, S.
2017-12-01
While government funding of scientific research has been the bedrock of scientific advances in the US, it is seldom quick or directly responsive to societal needs. If we are to effectively respond to the increasingly urgent needs for new science to address the environmental and social challenges faced by humanity and the environment we need to deploy new scientific models to augment government-centric approaches. The Environmental Defense Fund has developed an approach that accelerates the development and uptake of new science in pursuit of science-based policy to fill the gap while government research efforts are initiated. We utilized this approach in developing the data necessary to quantify methane emissions from the oil and gas supply chain. This effort was based on five key principles: studies led by an academic researchers; deployment of multiple methods whenever possible (e.g. top-down and bottom-up); all data made public (identity but not location masked when possible); external scientific review; results released in peer-reviewed scientific journals. The research to quantify methane emissions involved > 150 scientists from 40 institutions, resulting in 35 papers published over four years. In addition to the research community companies operating along the oil and gas value chain participated by providing access to sites/vehicles and funding for a portion of the academic research. The bulk of funding came from philanthropic sources. Overall the use of this alternative research/funding model allowed for the more rapid development of a robust body of policy-relevant knowledge that addressed an issue of high societal interest/value.
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Grand Challenges for Biological and Environmental Research: A Long-Term Vision
Energy Technology Data Exchange (ETDEWEB)
Arkin, A.; Baliga, N.; Braam, J.; Church, G.; Collins, J;
; Cottingham, R.; Ecker, J.; Gerstein, M.; Gilna, P.; Greenberg, J.; Handelsman, J.; Hubbard, S.; Joachimiak, A.; Liao, J.; Looger, L.; Meyerowitz, E.; Mjolness, E.; Petsko, G.; Sayler, G.; Simpson, M.; Stacey, G.; Sussman, M.; Tiedje, J.; Bader, D.; Cessi, P.; Collins, W.; Denning, S.; Dickinson, R.; Easterling, D.; Edmonds, J.; Feddema, J.; Field, C.; Fridlind, A.; Fung, I.; Held, I.; Jackson, R.; Janetos, A.; Large, W.; Leinen, M.; Leung, R.; Long, S.; Mace, G.; Masiello, C.; Meehl, G.; Ort, D.; Otto-Bliesner, B.; Penner, J.; Prather, M.; Randall, D.; Rasch, P.; Schneider, E.; Shugart, H.; Thornton, P.; Washington, W.; Wildung, R.; Wiscombe, W.; Zak, D.; Zhang, M.; Bielicki, J.; Buford, M.; Cleland, E.; Dale, V.; Duke, C.; Ehleringer, J.; Hecht, A.; Kammen, D.; Marland, G.; Pataki, D.; Riley, M. Robertson, P.; Hubbard, S. 2010-12-01
The interactions and feedbacks among plants, animals, microbes, humans, and the environment ultimately form the world in which we live. This world is now facing challenges from a growing and increasingly affluent human population whose numbers and lifestyles are driving ever greater energy demand and impacting climate. These and other contributing factors will make energy and climate sustainability extremely difficult to achieve over the 20-year time horizon that is the focus of this report. Despite these severe challenges, there is optimism that deeper understanding of our environment will enable us to mitigate detrimental effects, while also harnessing biological and climate systems to ensure a sustainable energy future. This effort is advanced by scientific inquiries in the fields of atmospheric chemistry and physics, biology, ecology, and subsurface science - all made possible by computing. The Office of Biological and Environmental Research (BER) within the Department of Energy's (DOE) Office of Science has a long history of bringing together researchers from different disciplines to address critical national needs in determining the biological and environmental impacts of energy production and use, characterizing the interplay of climate and energy, and collaborating with other agencies and DOE programs to improve the world's most powerful climate models. BER science focuses on three distinct areas: (1) What are the roles of Earth system components (atmosphere, land, oceans, sea ice, and the biosphere) in determining climate? (2) How is the information stored in a genome translated into microbial, plant, and ecosystem processes that influence biofuel production, climate feedbacks, and the natural cycling of carbon? (3) What are the biological, geochemical, and physical forces that govern the behavior of Earth's subsurface environment? Ultimately, the goal of BER science is to support experimentation and modeling that can reliably predict the
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Scientific activities in and about Greenland
DEFF Research Database (Denmark)
Graversen, Ebbe Krogh; Pedersen, Asger Dalsgaard
2018-01-01
This report presents the results of an investigation and analysis of opportunities, strengths and challenges of scientific activities involving Greenland as a research area or research object relative to other Arctic areas.......This report presents the results of an investigation and analysis of opportunities, strengths and challenges of scientific activities involving Greenland as a research area or research object relative to other Arctic areas....
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International Nuclear Information System (INIS)
Ianko, L.
1993-01-01
This short talk was the opening remarks to the attendees at this conference, presented by the Scientific Secretary, IWG-LMNPP, of the IAEA. This meeting is an effort to aid research on problems related to the general area of nuclear plant aging and life management. In particular it addresses fracture properties of reactor materials and components, both as installed, and at end of service condition. A major concern is relating measurements made on laboratory samples to properties displayed by actual reactor components
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Online Learning: Addressing Challenges and Seizing Opportunities. South Dakota
Alliance for Excellent Education, 2010
2010-01-01
America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…
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Online Learning: Addressing Challenges and Seizing Opportunities. North Dakota
Alliance for Excellent Education, 2010
2010-01-01
America's K-12 education system faces three significant challenges: (1) increased global demands for skilled workers, (2) significant financial shortfalls, and (3) a looming teacher shortage. Independently, these factors present significant challenges for U.S. schools. In combination, they create a national imperative for swift action to create a…
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Directory of Open Access Journals (Sweden)
Winston P Nagan
2016-05-01
Full Text Available The general framework of this paper is to focus on the evolution of scientific consciousness and the dramatic technological developments it has generated, which have vital and highly consequential consequences for social organization on a global basis. The central fact about the current technological revolution is the enormous challenges it provides for political and economic decision-making. The political and economic choices are often merged in a symbiotic wave of challenges. In politics, we have understood the background and challenges that confront homopoliticus. These challenges are even more pronounced as challenges for homoeconomicus. In short, homoeconomico-politicus is both an observer and a participator in the challenges of dramatic technological change. What ties these two concepts together is that they are fed by a form of scientific consciousness. Dramatic forces of change, now unleashed, literally require new paradigms of political and economic thinking to inform wise policy makers about sensible political and economic choices. Both economics and politics are dramatically interrelated and shaped by the philosophy of science known as Logical Positivism. The problem with this approach is that it demands a form of scientific objectivity that rigorously excludes the study of values in the science of politics and economics. But the broader level of scientific consciousness would virtually require that these disciplines adequately account for the value implications of their work. These generalized comments may be an appropriate introduction to a deeper understanding of the impact of technological changes on the organization of political economy at all levels of social organization from the local to the global. One of the issues that we seek to underscore in this paper is a better understanding of the idea of economic consciousness. It would seem to be obvious that economic consciousness influences economic theory and practice. In this
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Directory of Open Access Journals (Sweden)
Mannucci Anthony J.
2016-01-01
Full Text Available Interest in forecasting space weather in the thermosphere and ionosphere (T-I led to a community workshop held at NASA’s Jet Propulsion Laboratory in October, 2014. The workshop focus was “Scientific Challenges in Thermosphere-Ionosphere Forecasting” to emphasize that forecasting presumes a sufficiently advanced state of scientific knowledge, yet one that is still evolving. The purpose of the workshop, and this topical issue that arose from the workshop, was to discuss research frontiers that will lead to improved space weather forecasts. Three areas are discussed in some detail in this paper: (1 the role of lower atmosphere forcing in the response of the T-I to geomagnetic disturbances; (2 the significant deposition of energy at polar latitudes during geomagnetic disturbances; and (3 recent developments in understanding the propagation of coronal mass ejections through the heliosphere and prospects for forecasting the north-south component of the interplanetary magnetic field (IMF using observations at the Lagrangian L5 point. We describe other research presented at the workshop that appears in the topical issue. The possibility of establishing a “positive feedback loop” where improved scientific knowledge leads to improved forecasts is described (Siscoe 2006, Space Weather, 4, S01003; Mannucci 2012, Space Weather, 10, S07003.
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Teaching Climate Change to Future Teachers Using 'Real' Data: Challenges and Opportunities (Invited)
Petcovic, H. L.; Barone, S.; Fulford, J.
2013-12-01
A climate-literate public is essential to resolving pressing problems related to global change. Future elementary teachers are a critical audience in climate and climate change education, as they will introduce children in early grades (USA grades K-8, children ages 5-14) to fundamentals of the climate system, natural and anthropogenic drivers of climate change, and impacts of global change on human and natural systems. Here we describe challenges we have encountered in teaching topics of the carbon cycle, greenhouse gases, past climate, recent anthropogenic change, and carbon footprints to future elementary teachers. We also describe how we have met (to varying degrees of success) these challenges in an introductory earth science course that is specifically designed for this audience. Two prominent challenges we have encountered are: the complex nature of the scientific content of climate change, and robust misconceptions held by our students about these topics. To address the first challenge, we attempt to adjust the scientific content to a level appropriate for future K-8 teachers, without sacrificing too much accuracy or critical detail. To address the second challenge, we explicitly discuss alternate conceptions of each topic. The use of authentic data sets can also address both of these challenges. Yet incorporating 'real' climate and paleoclimate data into the classroom poses still an additional challenge of instructional design. We use a variety of teaching approaches in our laboratory-based course including student-designed experiments, computer simulations, physical models, and authentic data sets. We have found that students strongly prefer the physical models and experiments, because these are 'hands-on' and perceived as easily adaptable to the K-8 classroom. Students often express dislike for activities that use authentic data sets (for example, an activity using graphs of CO2 and methane concentrations in Vostok ice cores), in particular because they
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Sezen-Barrie, A.; Wolfson, J.
2015-12-01
An important goal of science education is to support development of citizens to participate in public debate and make informed decisions relevant to their lives and their worlds. The NGSS (Next Generation Science Standards) suggest engaging students in science classrooms in argumentation as a practice to help enhance the quality of evidence based decision making. In this multi-case study, we explored the use of written argumentation in eight secondary school science classrooms during a lesson on the relationship between ocean temperature and its CO2 holding capacity. All teachers of these classrooms were trained during a day long NSF funded Climate Literacy Workshop on the basic concepts of climate science, scientific practices and implementation of an activity called "It's a Gassy World". The data of the current study involved students' written arguments, teachers' written reflections on the implementation of the activity as well as field notes from the Climate Literacy Workshop. A qualitative discourse analysis of the data was used to find common themes around affordances and challenges of argument as a connective discourse for scientific practices to teach climate change. The findings show that participating in written argumentation process encouraged students to discuss their experimental design and use data interpretation for their evidences. However, the results also indicated the following challenges: a) teachers themselves need support in connecting their evidence to their claims, b) arguing a socioscientific issue creates a sensitive environment c) conceptual quality of an argument needs to be strengthen through background in courses other than science, and d) graphing skills (or lack of) can interfere with constructing scientifically accurate claims. This study has implications in effectively teaching climate change through argumentation, and thus creating opportunities for practicing authentic climate science research in K-12 classrooms.
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Scientific Needs for Future X-ray Sources in the U.S. -- A White Paper
Energy Technology Data Exchange (ETDEWEB)
Falcone, Roger; Stohr, Joachim; Bergmann, Uwe; Corlett, John; Galayda, John; Hastings, Jerry; Hettel, Bob; Hussain, Zahid; Kirz, Janos; McCurdy, Bill; Raubenheimer, Tor; Sannibale, Fernando; Seeman, John; Shen, Z.-X.; Schoenlein, Bob; Zholents, Alexander
2008-10-16
Many of the important challenges facing humanity, including developing alternative sources of energy and improving heath, are being addressed by advances that demand the improved understanding and control of matter. While the visualization, exploration, and manipulation of macroscopic matter have long been technological goals, scientific developments in the twentieth century have focused attention on understanding matter on the atomic scale through the underlying framework of quantum mechanics. Of special interest is matter that consists of natural or artificial nanoscale building blocks defined either by atomic structural arrangements or by electron or spin formations created by collective correlation effects. The essence of the challenge to the scientific community has been expressed in five grand challenges for directing matter and energy recently formulated by the Basic Energy Sciences Advisory Committee. These challenges focus on increasing our understanding of, and ultimately control of, matter at the level of atoms, electrons. and spins, as illustrated in Figure 1.1. Meeting these challenges will require new tools that extend our reach into regions of higher spatial, temporal, and energy resolution. Since the fundamental interaction that holds matter together is of electromagnetic origin, it is intuitively clear that electromagnetic radiation is the critical tool in the study of material properties. On the level of atoms, electrons and spins, x rays have proved especially valuable.
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Scientific Needs for Future X-Ray Sources in the U.S.: A White Paper
Energy Technology Data Exchange (ETDEWEB)
Falcone , Roger; Stohr, Joachim; Bergmann, Uwe; Corlett, John; Galayda, John; Hastings, Jerry; Robert Hettel, Zahid Hussain; Kirz, Janos; McCurdy, Bill; Raubenheimer, Tor; Fernando Sannibale, John Seeman; Shen, Z.-X.; Schoenlein, Robert; Zholents, Alexander; /SLAC /LBL, Berkeley
2008-10-22
Many of the important challenges facing humanity, including developing alternative sources of energy and improving health, are being addressed by advances that demand the improved understanding and control of matter. While the visualization, exploration, and manipulation of macroscopic matter have long been technological goals, scientific developments in the twentieth century have focused attention on understanding matter on the atomic scale through the underlying framework of quantum mechanics. Of special interest is matter that consists of natural or artificial nanoscale building blocks defined either by atomic structural arrangements or by electron or spin formations created by collective correlation effects (Figure 1.1). The essence of the challenge to the scientific community has been expressed in five grand challenges for directing matter and energy recently formulated by the Basic Energy Sciences Advisory Committee. These challenges focus on increasing our understanding of, and ultimately control of, matter at the level of atoms, electrons, and spins, as illustrated in Figure 1.1. Meeting these challenges will require new tools that extend our reach into regions of higher spatial, temporal, and energy resolution. Since the fundamental interaction that holds matter together is of electromagnetic origin, it is intuitively clear that electromagnetic radiation is the critical tool in the study of material properties. On the level of atoms, electrons and spins, x rays have proved especially valuable.
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Asner, Gregory P.
2011-06-01
stumbling blocks actually starts with the scientific community, which needs not only to develop highly accurate deforestation, degradation and carbon emission monitoring methods, but also to make those methods available to national governments and the supporting organizations orbiting those governments. This 'giving away' of the methods starts, but does not end, with the training provided by the scientific experts on the use of the monitoring tools. This effort must also involve a commitment to sustained support and capacity building until non-expert monitoring and reporting becomes routine. The scientific community must also make clear what is operational and what is research. Operational does not necessarily mean less accurate. Rather, achieving both operational status and high accuracy requires innovation. While an innovative, but one-time or infrequent, mapping of forest cover or carbon stocks has been the most common scientific contribution to REDD+, it alone does not constitute operational monitoring. However, it can contribute to a portfolio of techniques and products that must come together to form an operational monitoring and modeling approach. Australia's National Carbon Accounting System (NCAS; www.climatechange.gov.au/) is one such approach, and there are others developing (www.csr.ufmg.br/simamazonia/). Importantly, carbon accounting models can meet the REDD+ challenge, but only if the observations—the measurements—are high quality, high resolution, and synoptic in geographic scale (Asner 2009). Is there hope, and if so, is it based on real and present scientific progress? Real progress is being made, but much of the innovation has not landed in the reports provided by and for the UN and Intergovernmental Panel on Climate Change (IPCC). Yet this innovation is breaking serious barriers that extend and/or replace traditional forest inventory techniques, that use the latest satellite and aircraft technology on a cost-effective and repeated basis, and which
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Steele, Ric G.; Connelly, Mark A.; Palermo, Tonya M.; Ritterband, Lee M.
2014-01-01
Objective To provide an overview of common challenges that pediatric eHealth researchers may encounter when planning, developing, testing, and disseminating eHealth interventions along with proposed solutions for addressing these challenges. Methods The article draws on the existing eHealth literature and the authors’ collective experience in pediatric eHealth research. Results and conclusions The challenges associated with eHealth interventions and their proposed solutions are multifaceted and cut across a number of areas from eHealth program development through dissemination. Collaboration with a range of individuals (e.g., multidisciplinary colleagues, commercial entities, primary stakeholders) is the key to eHealth intervention success. To ensure adequate resources for design, development, and planning for sustainability, a number of public and private sources of funding are available. A study design that addresses ethical concerns and security issues is critical to ensure scientific integrity and intervention dissemination. Table I summarizes key issues to consider during eHealth intervention development, testing, and dissemination. PMID:24816766
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Doyle, John T; Kindness, Larry; Realbird, James; Eggers, Margaret J; Camper, Anne K
2018-03-21
Disparities in access to safe public drinking water are increasingly being recognized as contributing to health disparities and environmental injustice for vulnerable communities in the United States. As the Co-Directors of the Apsaálooke Water and Wastewater Authority (AWWWA) for the Crow Tribe, with our academic partners, we present here the multiple and complex challenges we have addressed in improving and maintaining tribal water and wastewater infrastructure, including the identification of diverse funding sources for infrastructure construction, the need for many kinds of specialized expertise and long-term stability of project personnel, ratepayer difficulty in paying for services, an ongoing legacy of inadequate infrastructure planning, and lack of water quality research capacity. As a tribal entity, the AWWWA faces additional challenges, including the complex jurisdictional issues affecting all phases of our work, lack of authority to create water districts, and additional legal and regulatory gaps-especially with regards to environmental protection. Despite these obstacles, the AWWWA and Crow Tribe have successfully upgraded much of the local water and wastewater infrastructure. We find that ensuring safe public drinking water for tribal and other disadvantaged U.S. communities will require comprehensive, community-engaged approaches across a broad range of stakeholders to successfully address these complex legal, regulatory, policy, community capacity, and financial challenges.
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Gelmon, Sherril; Bouranis, Nicole; Sandberg, Billie; Petchel, Shauna
2018-01-01
Patient-centered medical homes (PCMHs) are at the forefront of the transformation of primary care as part of health systems reform. Despite robust literature describing implementation challenges, few studies describe strategies being used to overcome these challenges. This article addresses this gap through observations of exemplary PCMHs in Oregon, where the Oregon Health Authority supports and recognizes Patient-Centered Primary Care Homes (PCPCH). Twenty exemplary PCPCHs were selected using program scores, with considerations for diversity in clinic characteristics. Between 2015 and 2016, semistructured interviews and focus groups were completed with 85 key informants. Clinics reported similar challenges implementing the PCPCH model, including shifting patterns of care use, fidelity to the PCPCH model, and refining care processes. The following ten implementation strategies emerged: expanding access through care teams, preventing unnecessary emergency department visits through patient outreach, improved communication and referral tracking with outside providers, prioritization of selected program metrics, implementing patient-centered practices, developing continuous improvement capacity through committees and "champions," incorporating preventive services and chronic disease management, standardization of workflows, customizing electronic health records, and integration of mental health. Clinic leaders benefited from understanding the local context in which they were operating. Despite differences in size, ownership, geography, and population, all clinic leaders were observed to be proponents of strategies commonly associated with a "learning organization": systems thinking, personal mastery, mental models, shared vision, and team. Clinics can draw on their own characteristics, use state resources, and look to established PCMHs to build the evidence base for implementation in primary care. © Copyright 2018 by the American Board of Family Medicine.
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London, Leslie; Tangwa, Godfrey; Matchaba-Hove, Reginald; Mkhize, Nhlanhla; Nwabueze, Remi; Nyika, Aceme; Westerholm, Peter
2014-06-23
International codes of ethics play an important role in guiding professional practice in developing countries. In the occupational health setting, codes developed by international agencies have substantial import on protecting working populations from harm. This is particularly so under globalisation which has transformed processes of production in fundamental ways across the globe. As part of the process of revising the Ethical Code of the International Commission on Occupational Health, an Africa Working Group addressed key challenges for the relevance and cogency of an ethical code in occupational health for an African context through an iterative consultative process. Firstly, even in the absence of strong legal systems of enforcement, and notwithstanding the value of legal institutionalisation of ethical codes, guidelines alone may offer advantageous routes to enhancing ethical practice in occupational health. Secondly, globalisation has particularly impacted on health and safety at workplaces in Africa, challenging occupational health professionals to be sensitive to, and actively redress imbalance of power. Thirdly, the different ways in which vulnerability is exemplified in the workplace in Africa often places the occupational health professional in invidious positions of Dual Loyalty. Fourth, the particular cultural emphasis in traditional African societies on collective responsibilities within the community impacts directly on how consent should be sought in occupational health practice, and how stigma should be dealt with, balancing individual autonomy with ideas of personhood that are more collective as in the African philosophy of ubuntu. To address stigma, practitioners need to be additionally sensitive to how power imbalances at the workplace intersect with traditional cultural norms related to solidarity. Lastly, particularly in the African context, the inseparability of workplace and community means that efforts to address workplace hazards demand
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2014-01-01
Background International codes of ethics play an important role in guiding professional practice in developing countries. In the occupational health setting, codes developed by international agencies have substantial import on protecting working populations from harm. This is particularly so under globalisation which has transformed processes of production in fundamental ways across the globe. As part of the process of revising the Ethical Code of the International Commission on Occupational Health, an Africa Working Group addressed key challenges for the relevance and cogency of an ethical code in occupational health for an African context through an iterative consultative process. Discussion Firstly, even in the absence of strong legal systems of enforcement, and notwithstanding the value of legal institutionalisation of ethical codes, guidelines alone may offer advantageous routes to enhancing ethical practice in occupational health. Secondly, globalisation has particularly impacted on health and safety at workplaces in Africa, challenging occupational health professionals to be sensitive to, and actively redress imbalance of power. Thirdly, the different ways in which vulnerability is exemplified in the workplace in Africa often places the occupational health professional in invidious positions of Dual Loyalty. Fourth, the particular cultural emphasis in traditional African societies on collective responsibilities within the community impacts directly on how consent should be sought in occupational health practice, and how stigma should be dealt with, balancing individual autonomy with ideas of personhood that are more collective as in the African philosophy of ubuntu. To address stigma, practitioners need to be additionally sensitive to how power imbalances at the workplace intersect with traditional cultural norms related to solidarity. Lastly, particularly in the African context, the inseparability of workplace and community means that efforts to address
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50 CFR 21.23 - Scientific collecting permits.
2010-10-01
... take, transport, or possess migratory birds, their parts, nests, or eggs for scientific research or... project involved; (4) Name and address of the public, scientific, or educational institution to which all... possessed under authority of a scientific collecting permit must be donated and transferred to the public...
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DEFF Research Database (Denmark)
EFSA PPR Panel (EFSA Panel on Plant Protection Products and their Residues); Ockleford, Colin; Adriaanse, Paulien
2017-01-01
Following a request from EFSA, the Panel on Plant Protection Products and their Residues developed an opinion on the science behind the risk assessment of plant protection products for in-soil organisms. The current risk assessment scheme is reviewed, taking into account new regulatory frameworks...... exposure routes for in-soil organisms and the potential direct and indirect effects is proposed. In order to address species recovery and long-term impacts of PPPs, the use of population models is also proposed....... and scientific developments. Proposals are made for specific protection goals for in-soil organisms being key drivers for relevant ecosystem services in agricultural landscapes such as nutrient cycling, soil structure, pest control and biodiversity. Considering the time-scales and biological processes related...
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Scientific Opportunities to Reduce Risk in Nuclear Process Science
International Nuclear Information System (INIS)
Bredt, Paul R.; Felmy, Andrew R.; Gauglitz, Phillip A.; Hobbs, David T.; Krahn, Steve; Machara, N.; Mcilwain, Michael; Moyer, Bruce A.; Poloski, Adam P.; Subramanian, K.; Vienna, John D.; Wilmarth, B.
2008-01-01
Cleaning up the nation's nuclear weapons complex remains as one of the most technologically challenging and financially costly problems facing the U.S. Department of Energy (DOE). Safety, cost, and technological challenges have often delayed progress in retrieval, processing, and final disposition of high-level waste, spent nuclear fuel, and challenging materials. Some of the issues result from the difficulty and complexity of the technological issues; others have programmatic bases, such as contracting strategies that may provide undue focus on near-term, specific clean-up goals or difficulty in developing and maintaining stakeholder confidence in the proposed solutions. We propose that independent basic fundamental science research focused on the full cleanup life-cycle offers an opportunity to help address these challenges by providing (1) scientific insight into the fundamental mechanisms involved in currently selected processing and disposal options, (2) a rational path to the development of alternative technologies should the primary options fail, (3) confidence that models that predict long-term performance of different disposal options are based upon the best available science, (4) fundamental science discovery that enables transformational solutions to revolutionize the current baseline processes.
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Darch, Peter T.; Sands, Ashley E.
2016-06-01
Sky surveys, such as the Sloan Digital Sky Survey (SDSS) and the Large Synoptic Survey Telescope (LSST), generate data on an unprecedented scale. While many scientific projects span a few years from conception to completion, sky surveys are typically on the scale of decades. This paper focuses on critical challenges arising from long timescales, and how sky surveys address these challenges.We present findings from a study of LSST, comprising interviews (n=58) and observation. Conceived in the 1990s, the LSST Corporation was formed in 2003, and construction began in 2014. LSST will commence data collection operations in 2022 for ten years.One challenge arising from this long timescale is uncertainty about future needs of the astronomers who will use these data many years hence. Sources of uncertainty include scientific questions to be posed, astronomical phenomena to be studied, and tools and practices these astronomers will have at their disposal. These uncertainties are magnified by the rapid technological and scientific developments anticipated between now and the start of LSST operations.LSST is implementing a range of strategies to address these challenges. Some strategies involve delaying resolution of uncertainty, placing this resolution in the hands of future data users. Other strategies aim to reduce uncertainty by shaping astronomers’ data analysis practices so that these practices will integrate well with LSST once operations begin.One approach that exemplifies both types of strategy is the decision to make LSST data management software open source, even now as it is being developed. This policy will enable future data users to adapt this software to evolving needs. In addition, LSST intends for astronomers to start using this software well in advance of 2022, thereby embedding LSST software and data analysis approaches in the practices of astronomers.These findings strengthen arguments for making the software supporting sky surveys available as open
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Henkel, Heather S.
2007-01-01
In March 2006, the U.S. Geological Survey (USGS) held the first Scientific Information Management (SIM) Workshop in Reston, Virginia. The workshop brought together more than 150 SIM professionals from across the organization to discuss the range and importance of SIM problems, identify common challenges and solutions, and investigate the use and value of “communities of practice” (CoP) as mechanisms to address these issues. The 3-day workshop began with presentations of SIM challenges faced by the Long Term Ecological Research (LTER) network and two USGS programs from geology and hydrology. These presentations were followed by a keynote address and discussion of CoP by Dr. Etienne Wenger, a pioneer and leading expert in CoP, who defined them as "groups of people who share a passion for something that they know how to do and who interact regularly to learn how to do it better." Wenger addressed the roles and characteristics of CoP, how they complement formal organizational structures, and how they can be fostered. Following this motivating overview, five panelists (including Dr. Wenger) with CoP experience in different institutional settings provided their perspectives and lessons learned. The first day closed with an open discussion on the potential intersection of SIM at the USGS with SIM challenges and the potential for CoP. The second session began the process of developing a common vocabulary for both scientific data management and CoP, and a list of eight guiding principles for information management were proposed for discussion and constructive criticism. Following this discussion, 20 live demonstrations and posters of SIM tools developed by various USGS programs and projects were presented. Two community-building sessions were held to explore the next steps in 12 specific areas: Archiving of Scientific Data and Information; Database Networks; Digital Libraries; Emerging Workforce; Field Data for Small Research Projects; Knowledge Capture; Knowledge
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Human-Interaction Challenges in UAV-Based Autonomous Surveillance
Freed, Michael; Harris, Robert; Shafto, Michael G.
2004-01-01
Autonomous UAVs provide a platform for intelligent surveillance in application domains ranging from security and military operations to scientific information gathering and land management. Surveillance tasks are often long duration, requiring that any approach be adaptive to changes in the environment or user needs. We describe a decision- theoretic model of surveillance, appropriate for use on our autonomous helicopter, that provides a basis for optimizing the value of information returned by the UAV. From this approach arise a range of challenges in making this framework practical for use by human operators lacking specialized knowledge of autonomy and mathematics. This paper describes our platform and approach, then describes human-interaction challenges arising from this approach that we have identified and begun to address.
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Directory of Open Access Journals (Sweden)
Carla Costa Garcia
2010-12-01
Full Text Available A disseminação da prática de coautoria no Brasil e na comunidade internacional tem sido acompanhada pelo aumento no registro de fraudes, manipulações e outros desvios ao definir a responsabilidade por um trabalho científico. Este artigo discorre sobre os critérios utilizados para atribuição da autoria, as razões para o crescimento dos índices de coautoria e os desafios para estabelecer a autoria em periódicos eletrônicos. Por meio de revisão bibliográfica e estudo de caso (a partir de levantamento de base de dados, aponta caminhos para evitar que "desvios de comportamento" quanto à atribuição de autoria abalem a credibilidade da ciência.The dissemination of the practice of collaborative authorship (coauthorship in Brazil and in the international scientific community has been accompanied by an increasing occurrence of frauds, manipulations and other deviations in the assignment of responsibility for a scientific paper. This article discusses the criteria for authorship attribution, the reasons for the growing indices of coauthorship and the challenges to determine authorship in electronic journals. Through literature review and case study (bibliographic search in scientific database, it shows ways to avoid that "misbehaviors" related to the authorship attribution affect the credibility of science.
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Hassanpour, Saeed; O?Connor, Martin J; Das, Amar K
2013-01-01
Background A variety of informatics approaches have been developed that use information retrieval, NLP and text-mining techniques to identify biomedical concepts and relations within scientific publications or their sentences. These approaches have not typically addressed the challenge of extracting more complex knowledge such as biomedical definitions. In our efforts to facilitate knowledge acquisition of rule-based definitions of autism phenotypes, we have developed a novel semantic-based t...
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Scientific Frontiers in the Management of Coral Reefs
Directory of Open Access Journals (Sweden)
Shankar eAswani
2015-07-01
Full Text Available Coral reefs are subjected globally to a variety of natural and anthropogenic stressors that often act synergistically. Today, reversing ongoing and future coral reef degradation presents significant challenges and countering this negative trend will take considerable efforts and investments. Scientific knowledge can inform and guide the requisite decision-making process and offer practical solutions to the problem of protection as the effects of climate change exacerbate. However, implementation of solutions presently lags far behind the pace required to reverse global declines, and there is a need for an urgent and significant step-up in the extent and range of strategies being implemented. In this paper, we consider scientific frontiers in natural and social science research that can help build stronger support for reef management and improve the efficacy of interventions. We cover various areas including: (1 enhancing the case for reef conservation and management, (2 dealing with local stressors on reefs, (3 addressing global climate change impacts, (4 and reviewing various approaches to the governance of coral reefs. In sum, we consider scientific frontiers in natural and social science that will require further attention in coming years as managers’ work towards building stronger support for reef management and improve the efficacy of local interventions.
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GEOSS: Addressing Big Data Challenges
Nativi, S.; Craglia, M.; Ochiai, O.
2014-12-01
In the sector of Earth Observation, the explosion of data is due to many factors including: new satellite constellations, the increased capabilities of sensor technologies, social media, crowdsourcing, and the need for multidisciplinary and collaborative research to face Global Changes. In this area, there are many expectations and concerns about Big Data. Vendors have attempted to use this term for their commercial purposes. It is necessary to understand whether Big Data is a radical shift or an incremental change for the existing digital infrastructures. This presentation tries to explore and discuss the impact of Big Data challenges and new capabilities on the Global Earth Observation System of Systems (GEOSS) and particularly on its common digital infrastructure called GCI. GEOSS is a global and flexible network of content providers allowing decision makers to access an extraordinary range of data and information at their desk. The impact of the Big Data dimensionalities (commonly known as 'V' axes: volume, variety, velocity, veracity, visualization) on GEOSS is discussed. The main solutions and experimentation developed by GEOSS along these axes are introduced and analyzed. GEOSS is a pioneering framework for global and multidisciplinary data sharing in the Earth Observation realm; its experience on Big Data is valuable for the many lessons learned.
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Scientific Data Management Center for Enabling Technologies
Energy Technology Data Exchange (ETDEWEB)
Vouk, Mladen A.
2013-01-15
data management technologies to DOE application scientists in astrophysics, climate, fusion, and biology. Equally important, it established collaborations with these scientists to better understand their science as well as their forthcoming data management and data analytics challenges. Building on our early successes, we have greatly enhanced, robustified, and deployed our technology to these communities. In some cases, we identified new needs that have been addressed in order to simplify the use of our technology by scientists. This report summarizes our work so far in SciDAC-2. Our approach is to employ an evolutionary development and deployment process: from research through prototypes to deployment and infrastructure. Accordingly, we have organized our activities in three layers that abstract the end-to-end data flow described above. We labeled the layers (from bottom to top): a) Storage Efficient Access (SEA), b) Data Mining and Analysis (DMA), c) Scientific Process Automation (SPA). The SEA layer is immediately on top of hardware, operating systems, file systems, and mass storage systems, and provides parallel data access technology, and transparent access to archival storage. The DMA layer, which builds on the functionality of the SEA layer, consists of indexing, feature identification, and parallel statistical analysis technology. The SPA layer, which is on top of the DMA layer, provides the ability to compose scientific workflows from the components in the DMA layer as well as application specific modules. NCSU work performed under this contract was primarily at the SPA layer.
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48 CFR 435.010 - Scientific and technical reports.
2010-10-01
... CATEGORIES OF CONTRACTING RESEARCH AND DEVELOPMENT CONTRACTING 435.010 Scientific and technical reports... all scientific and technical reports to the National Technical Information Service at the address... 48 Federal Acquisition Regulations System 4 2010-10-01 2010-10-01 false Scientific and technical...
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Human missions to Mars: issues and challenges
Race, M.; Kminek, G.
Recent announcements of the planned future human exploration of Mars by both European and US space agencies have raised a host of questions and challenges that must be addressed in advance of long-duration human missions. While detailed mission planning is a long way off, numerous issues can already be identified in the broad context of planetary protection. In this session, a panel of experts will provide brief overviews of the types of challenges ahead, such as the protection of the martian environment; the integration of human and robotic mission elements and operations; precursor scientific information necessary to plan human missions; development and use of nuclear and other technologies for the protection and support of astronauts during the mission; protection of Earth upon return; and societal and ethical questions about human exploration. The session has been designed to encourage and incorporate audience participation in the discussion about the issues and challenges ahead.
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Computational challenges in atomic, molecular and optical physics.
Taylor, Kenneth T
2002-06-15
Six challenges are discussed. These are the laser-driven helium atom; the laser-driven hydrogen molecule and hydrogen molecular ion; electron scattering (with ionization) from one-electron atoms; the vibrational and rotational structure of molecules such as H(3)(+) and water at their dissociation limits; laser-heated clusters; and quantum degeneracy and Bose-Einstein condensation. The first four concern fundamental few-body systems where use of high-performance computing (HPC) is currently making possible accurate modelling from first principles. This leads to reliable predictions and support for laboratory experiment as well as true understanding of the dynamics. Important aspects of these challenges addressable only via a terascale facility are set out. Such a facility makes the last two challenges in the above list meaningfully accessible for the first time, and the scientific interest together with the prospective role for HPC in these is emphasized.
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The Scientific Competitiveness of Nations.
Cimini, Giulio; Gabrielli, Andrea; Sylos Labini, Francesco
2014-01-01
We use citation data of scientific articles produced by individual nations in different scientific domains to determine the structure and efficiency of national research systems. We characterize the scientific fitness of each nation-that is, the competitiveness of its research system-and the complexity of each scientific domain by means of a non-linear iterative algorithm able to assess quantitatively the advantage of scientific diversification. We find that technological leading nations, beyond having the largest production of scientific papers and the largest number of citations, do not specialize in a few scientific domains. Rather, they diversify as much as possible their research system. On the other side, less developed nations are competitive only in scientific domains where also many other nations are present. Diversification thus represents the key element that correlates with scientific and technological competitiveness. A remarkable implication of this structure of the scientific competition is that the scientific domains playing the role of "markers" of national scientific competitiveness are those not necessarily of high technological requirements, but rather addressing the most "sophisticated" needs of the society.
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Near Real-time Scientific Data Analysis and Visualization with the ArcGIS Platform
Shrestha, S. R.; Viswambharan, V.; Doshi, A.
2017-12-01
Scientific multidimensional data are generated from a variety of sources and platforms. These datasets are mostly produced by earth observation and/or modeling systems. Agencies like NASA, NOAA, USGS, and ESA produce large volumes of near real-time observation, forecast, and historical data that drives fundamental research and its applications in larger aspects of humanity from basic decision making to disaster response. A common big data challenge for organizations working with multidimensional scientific data and imagery collections is the time and resources required to manage and process such large volumes and varieties of data. The challenge of adopting data driven real-time visualization and analysis, as well as the need to share these large datasets, workflows, and information products to wider and more diverse communities, brings an opportunity to use the ArcGIS platform to handle such demand. In recent years, a significant effort has put in expanding the capabilities of ArcGIS to support multidimensional scientific data across the platform. New capabilities in ArcGIS to support scientific data management, processing, and analysis as well as creating information products from large volumes of data using the image server technology are becoming widely used in earth science and across other domains. We will discuss and share the challenges associated with big data by the geospatial science community and how we have addressed these challenges in the ArcGIS platform. We will share few use cases, such as NOAA High Resolution Refresh Radar (HRRR) data, that demonstrate how we access large collections of near real-time data (that are stored on-premise or on the cloud), disseminate them dynamically, process and analyze them on-the-fly, and serve them to a variety of geospatial applications. We will also share how on-the-fly processing using raster functions capabilities, can be extended to create persisted data and information products using raster analytics
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Directory of Open Access Journals (Sweden)
Sergey V. Rasskazov
2010-01-01
Full Text Available N.A. Florensov and N.A. Logatchev pioneered development of fundamental concepts of the structure and evolution of the Baikal system of rift basins. At the turn to the 21st century, in view of the wide availability of scientific research data on the Cenozoic continental rift zones located in Eurasia, Africa and North America, and taking into account the application of new research methods and options to process and analyze huge amounts of geological and geophysical data, a priority was comprehensive modeling of rifting from its origin to the current period of time. This scientific challenge was addressed by the research team under the leadership of N.A. Logachev.
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Good practices and challenges in addressing poliomyelitis and measles in the European Union.
Kinsman, John; Stöven, Svenja; Elgh, Fredrik; Murillo, Pilar; Sulzner, Michael
2018-04-06
All European Union (EU) and European Economic Area (EEA) Member States have pledged to ensure political commitment towards sustaining the region's poliomyelitis-free status and eliminating measles. However, there remain significant gaps between policy and practice in many countries. This article reports on an assessment conducted for the European Commission that aimed to support improvements in preparedness and response to poliomyelitis and measles in Europe. A documentary review was complemented by qualitative interviews with professionals working in International and EU agencies, and in at-risk or recently affected EU/EEA Member States (six each for poliomyelitis and measles). Twenty-six interviews were conducted on poliomyelitis and 24 on measles; the data were subjected to thematic analysis. Preliminary findings were then discussed at a Consensus Workshop with 22 of the interviewees and eight other experts. Generic or disease-specific plans exist in the participating countries and cross-border communications during outbreaks were generally reported as satisfactory. However, surveillance systems are of uneven quality, and clinical expertise for the two diseases is limited by a lack of experience. Serious breaches of protocol have recently been reported from companies producing poliomyelitis vaccines, and vaccine coverage rates for both diseases were also sub-optimal. A set of suggested good practices to address these and other challenges is presented. Poliomyelitis and measles should be brought fully onto the policy agendas of all EU/EEA Member States, and adequate resources provided to address them. Each country must abide by the relevant commitments that they have already made.
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Scientific approaches to AIDS prevention and control in China.
Teng, T; Shao, Y
2011-04-01
The HIV epidemic in China started among intravenous drug users in the late 1980s. The second wave of the epidemic was caused by an outbreak in the paid plasma donors in central China in the mid-1990s. Sexually transmitted HIV cases have steadily increased and comprised more than half the reported HIV/AIDS infections since 2007. In the last 5 years, there has been a sharp increase of HIV infection in men who have sex with men. The HIV epidemic in China has expanded from high-risk groups to the general population and from rural regions to urban areas. This brief article discusses the history of HIV epidemics in China and the challenges facing the current AIDS control efforts in the country. It explains that only scientific approaches can sustain the national AIDS control programs and introduce the type of research needed to address those challenges. The selected research areas include molecular epidemiology, drug resistance surveillance, and the Chinese HIV vaccine research.
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Lindsey, Merry L; Mayr, Manuel; Gomes, Aldrin V; Delles, Christian; Arrell, D Kent; Murphy, Anne M; Lange, Richard A; Costello, Catherine E; Jin, Yu-Fang; Laskowitz, Daniel T; Sam, Flora; Terzic, Andre; Van Eyk, Jennifer; Srinivas, Pothur R
2015-09-01
The year 2014 marked the 20th anniversary of the coining of the term proteomics. The purpose of this scientific statement is to summarize advances over this period that have catalyzed our capacity to address the experimental, translational, and clinical implications of proteomics as applied to cardiovascular health and disease and to evaluate the current status of the field. Key successes that have energized the field are delineated; opportunities for proteomics to drive basic science research, facilitate clinical translation, and establish diagnostic and therapeutic healthcare algorithms are discussed; and challenges that remain to be solved before proteomic technologies can be readily translated from scientific discoveries to meaningful advances in cardiovascular care are addressed. Proteomics is the result of disruptive technologies, namely, mass spectrometry and database searching, which drove protein analysis from 1 protein at a time to protein mixture analyses that enable large-scale analysis of proteins and facilitate paradigm shifts in biological concepts that address important clinical questions. Over the past 20 years, the field of proteomics has matured, yet it is still developing rapidly. The scope of this statement will extend beyond the reaches of a typical review article and offer guidance on the use of next-generation proteomics for future scientific discovery in the basic research laboratory and clinical settings. © 2015 American Heart Association, Inc.
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Waddell, Steve; Cornell, Sarah; Hsueh, Joe; Ozer, Ceren; McLachlan, Milla; Birney, Anna
2015-04-01
Most action to address contemporary complex challenges, including the urgent issues of global sustainability, occurs piecemeal and without meaningful guidance from leading complex change knowledge and methods. The potential benefit of using such knowledge is greater efficacy of effort and investment. However, this knowledge and its associated tools and methods are under-utilized because understanding about them is low, fragmented between diverse knowledge traditions, and often requires shifts in mindsets and skills from expert-led to participant-based action. We have been engaged in diverse action-oriented research efforts in Large System Change for sustainability. For us, "large" systems can be characterized as large-scale systems - up to global - with many components, of many kinds (physical, biological, institutional, cultural/conceptual), operating at multiple levels, driven by multiple forces, and presenting major challenges for people involved. We see change of such systems as complex challenges, in contrast with simple or complicated problems, or chaotic situations. In other words, issues and sub-systems have unclear boundaries, interact with each other, and are often contradictory; dynamics are non-linear; issues are not "controllable", and "solutions" are "emergent" and often paradoxical. Since choices are opportunity-, power- and value-driven, these social, institutional and cultural factors need to be made explicit in any actionable theory of change. Our emerging network is sharing and building a knowledge base of experience, heuristics, and theories of change from multiple disciplines and practice domains. We will present our views on focal issues for the development of the field of large system change, which include processes of goal-setting and alignment; leverage of systemic transitions and transformation; and the role of choice in influencing critical change processes, when only some sub-systems or levels of the system behave in purposeful ways
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Dellafiora, Luca; Dall'Asta, Chiara
2017-01-04
The presence of mycotoxins in food represents a severe threat for public health and welfare, and poses relevant research challenges in the food toxicology field. Nowadays, food toxicologists have to provide answers to food-related toxicological issues, but at the same time they should provide the appropriate knowledge in background to effectively support the evidence-based decision-making in food safety. Therefore, keeping in mind that regulatory actions should be based on sound scientific findings, the present opinion addresses the main challenges in providing reliable data for supporting the risk assessment of foodborne mycotoxins.
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Fostering Scientific and Numerate Practices in Journalism to Support Rapid Public Learning
Directory of Open Access Journals (Sweden)
Louise Yarnall
2017-01-01
Full Text Available Journalism has the potential––and arguably the mandate––to expand public understanding of societally important phenomena. However, some methods for more effectively educating the public have been persistently underutilized: in particular, embedding informative numerical rates and efficient scientific explanations in news reports. In the current era of disrupting and downsizing the news business, the challenges to using such methods have only increased. To address this problem, this article seeks to (a raise awareness about the psychological reasons that help explain why it is crucial to use such elements in news reports, and (b exhibit some methods for doing so that require modest effort. Building on a review of relevant psychological literatures, principles, and existing reporting methods, we describe findings from a series of cognitive-scientific studies that demonstrate how using key––and relatively minimal––scientific and numerical elements can enhance public learning from news reports. We conclude by also describing curricula and resources designed to help journalists and bloggers use these methods.
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Directory of Open Access Journals (Sweden)
Grace Mburu
2017-07-01
Conclusion: South Africa’s HRH strategy for the Health Sector 2012/13–2015/16 had highlighted the key challenges raised by respondents and identified strategies aimed at addressing these challenges. Implementation of these strategies is key to improving both living and working conditions, and providing health personnel with opportunities for further development will require inter-ministerial collaboration if the HRH 2030 objectives are to be realised.
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Talbot, Bryan; Zhou, Shu-Jia; Higgins, Glenn
2002-01-01
One of the most significant challenges in large-scale climate modeling, as well as in high-performance computing in other scientific fields, is that of effectively integrating many software models from multiple contributors. A software framework facilitates the integration task. both in the development and runtime stages of the simulation. Effective software frameworks reduce the programming burden for the investigators, freeing them to focus more on the science and less on the parallel communication implementation, while maintaining high performance across numerous supercomputer and workstation architectures. This document proposes a strawman framework design for the climate community based on the integration of Cactus, from the relativistic physics community, and UCLA/UCB Distributed Data Broker (DDB) from the climate community. This design is the result of an extensive survey of climate models and frameworks in the climate community as well as frameworks from many other scientific communities. The design addresses fundamental development and runtime needs using Cactus, a framework with interfaces for FORTRAN and C-based languages, and high-performance model communication needs using DDB. This document also specifically explores object-oriented design issues in the context of climate modeling as well as climate modeling issues in terms of object-oriented design.
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Scientific publishing: some food for thought
Directory of Open Access Journals (Sweden)
Vittorio Bo
2007-03-01
Full Text Available Scientific publishing, here to be considered in a broader sense, as publishing of both specialised scientific journals and science popularisation works addressed to a wider audience, has been sailing for some years on troubled waters. To gather some possible food for thought is the purpose of this brief article.
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Extracting Core Claims from Scientific Articles
Jansen, Tom; Kuhn, Tobias
2017-01-01
The number of scientific articles has grown rapidly over the years and there are no signs that this growth will slow down in the near future. Because of this, it becomes increasingly difficult to keep up with the latest developments in a scientific field. To address this problem, we present here an
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Challenges in Analyzing the Biological Effects of Resveratrol
DEFF Research Database (Denmark)
Erdogan, Cihan Süleyman; Vang, Ole
2016-01-01
The suggested health effects (e.g., disease prevention) of dietary bioactive compounds such as resveratrol are challenging to prove in comparison to man-made drugs developed for therapeutic purposes. Dietary bioactive compounds have multiple cellular targets and therefore have a variety of biolog......The suggested health effects (e.g., disease prevention) of dietary bioactive compounds such as resveratrol are challenging to prove in comparison to man-made drugs developed for therapeutic purposes. Dietary bioactive compounds have multiple cellular targets and therefore have a variety...... research. Questions we address include: (1) Is the combinatorial effect of resveratrol and other compounds real? (2) What are the real and relevant doses of resveratrol after administration? and (3) Is it possible to estimate the preventive effect of resveratrol by clinical trials using standard...... experimental designs? The examples concerning resveratrol taken from the scientific literature are mainly from 2010 and later. The challenges pointed out in this review are similar to most naturally occurring bioactive compounds...
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Scientific visualization uncertainty, multifield, biomedical, and scalable visualization
Chen, Min; Johnson, Christopher; Kaufman, Arie; Hagen, Hans
2014-01-01
Based on the seminar that took place in Dagstuhl, Germany in June 2011, this contributed volume studies the four important topics within the scientific visualization field: uncertainty visualization, multifield visualization, biomedical visualization and scalable visualization. • Uncertainty visualization deals with uncertain data from simulations or sampled data, uncertainty due to the mathematical processes operating on the data, and uncertainty in the visual representation, • Multifield visualization addresses the need to depict multiple data at individual locations and the combination of multiple datasets, • Biomedical is a vast field with select subtopics addressed from scanning methodologies to structural applications to biological applications, • Scalability in scientific visualization is critical as data grows and computational devices range from hand-held mobile devices to exascale computational platforms. Scientific Visualization will be useful to practitioners of scientific visualization, ...
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CAWR: Two institutions join forces in a cluster by addressing the grand challenges of water research
Jaeckel, Greta; Braeckevelt, Mareike
2017-04-01
The Center for Advanced Water Research (CAWR) brings together the water competences of two German research institutions: Helmholtz Centre for Environmental Research - UFZ and the Technische Universität Dresden (TUD). Highly qualified scientists are jointly tackling some of the key challenges in the water sector in an outstanding breadth of research topics and at the same time with a profound disciplinary expertise. Our mission is: "Save water for humans and environment", because water in a good quality and adequate quantity is a fundamental basis of life for humankind and the environment. In many global challenges, such as food or energy security, human health and ecosystems, flood defence and droughts or the provision of drinking water and sanitation systems, water is becoming a very critical element for a sustainable society in Germany, in Europe and worldwide. The CAWR focusses its work on the fields of research, education & training as well as transfer. The CAWR was established in 2013. Over 3 years the activities within the three pillars and the six thematic priority research fields ( 1) Understanding processes: water cycle and water quality, 2): Water quantity and scarcity in the regional context, 3): Urban Water Systems, 4): Methods of data collection and information processing, 5): Societal and climate change, 6): Water governance) were presented within: • the scientific community (newsletters, publication highlights, workshops with different new formats, conferences) • to national and international stakeholders from policy, industry and society (workshops, opinion papers) • public media (TV, radio stations, Newspapers, brochures, videoclips via youtube…) This PICO presentation by Greta Jäckel (scientific management of CAWR) should show which tools for the presentation of research results are useful and which influence they have on different target groups. A bunch of examples for effective and also less successful instruments to present important
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International Nuclear Information System (INIS)
Rengel, M.T.; Kristofzski, J.G.; Schubert, A.L.
2002-01-01
Decommissioning of nuclear submarines, disposal of highly enriched uranium and defense plutonium as well as processing of high-level wastes are among the most challenging issues of addressing radiation legacy of the 20th century. USA and Russia are the two primary countries that have to deal with the challenge and where most of the fissile materials to be processed are concentrated, nuclear fuel and high-level radioactive waste are stored, and multiple industrial sites and nuclear weapons production facilities are located. In the US, CH2M HILL is managing two of the most important nuclear projects being conducted by the US Department of Energy at the Rocky Flats Environmental Technology Site and at the DOE Hanford Site (177 underground tanks at this site contain 60 percent of the United States' high-level radioactive wastes). Within the framework of the Russian Federal special program 'Radioactive Waste and Spent Nuclear Materials Management, Utilization and Disposal for 1996-2005' works were carried out on the Karachai lake covering with soil, highly active radwaste vitrification and fractionation at the 'Mayak' combine. Currently there is a discussion of launching joint Russian-American initiatives including comparative studies of environmental and public health impacts from high-level waste vitrification and plutonium stabilization processes in Russia and high-level waste removal from tanks in the USA and of continuing comprehensive research with the RADSITE project (USA, European Union, Japan, China and India) using coordinated approaches in 2000-2003. This paper presents comparative studies, technical approaches, and regulatory strategies to address the challenges of managing and closing highly enriched uranium, plutonium, and high level waste sites. (author)
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Addressing the Challenges in Tonsillectomy Research to Inform Health Care Policy: A Review.
Mandavia, Rishi; Schilder, Anne G M; Dimitriadis, Panagiotis A; Mossialos, Elias
2017-09-01
Eighty-five percent of investment in medical research has been wasted, with lack of effect on clinical practice and policy. There is increasing effort to improve the likelihood of research being used to influence clinical practice and policy. Tonsillectomy is one of the most common otorhinolaryngologic surgical procedures, and its frequency, cost, and morbidity create a clear need for evidence-based guidelines and policy. The first systematic review on tonsillectomy was conducted 40 years ago and highlighted the lack of definitive evidence for the procedure. Since that study, the body of evidence has still not been able to sufficiently inform policy. This review provides an overview of the key challenges in research to inform tonsillectomy policy and recommendations to help bridge the evidence-policy gap. The challenges in using research to inform policy can be summarized as 4 main themes: (1) non-policy-focused evidence and lack of available evidence, (2) quality of evidence, (3) communication of research findings, and (4) coordinating time frames. Researchers and decision makers should be aware of the limitations of research designs and conflicts of interest that can undermine policy decisions. Researchers must work with decision makers and patients throughout the research process to identify areas of unmet need and political priority, align research and policy time frames, and disseminate research findings. Incentives for researchers should be reorganized to promote dissemination of findings. It is important to consider why evidence gaps in tonsillectomy research have not been addressed during the past 40 years despite considerable investment in time and resources. These findings and recommendations will help produce research that is more responsive to policy gaps and more likely to result in policy changes.
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Scientific developments of liquid crystal-based optical memory: a review
Prakash, Jai; Chandran, Achu; Biradar, Ashok M.
2017-01-01
The memory behavior in liquid crystals (LCs), although rarely observed, has made very significant headway over the past three decades since their discovery in nematic type LCs. It has gone from a mere scientific curiosity to application in variety of commodities. The memory element formed by numerous LCs have been protected by patents, and some commercialized, and used as compensation to non-volatile memory devices, and as memory in personal computers and digital cameras. They also have the low cost, large area, high speed, and high density memory needed for advanced computers and digital electronics. Short and long duration memory behavior for industrial applications have been obtained from several LC materials, and an LC memory with interesting features and applications has been demonstrated using numerous LCs. However, considerable challenges still exist in searching for highly efficient, stable, and long-lifespan materials and methods so that the development of useful memory devices is possible. This review focuses on the scientific and technological approach of fascinating applications of LC-based memory. We address the introduction, development status, novel design and engineering principles, and parameters of LC memory. We also address how the amalgamation of LCs could bring significant change/improvement in memory effects in the emerging field of nanotechnology, and the application of LC memory as the active component for futuristic and interesting memory devices.
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EPA scientific integrity policy draft
Showstack, Randy
2011-08-01
The U.S. Environmental Protection Agency (EPA) issued its draft scientific integrity policy on 5 August. The draft policy addresses scientific ethical standards, communications with the public, the use of advisory committees and peer review, and professional development. The draft policy was developed by an ad hoc group of EPA senior staff and scientists in response to a December 2010 memorandum on scientific integrity from the White House Office of Science and Technology Policy. The agency is accepting public comments on the draft through 6 September; comments should be sent to osa.staff@epa.gov. For more information, see http://www.epa.gov/stpc/pdfs/draft-scientific-integrity-policy-aug2011.pdf.
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Designing a solution to enable agency-academic scientific collaboration for disasters
Directory of Open Access Journals (Sweden)
Lindley A. Mease
2017-06-01
Full Text Available As large-scale environmental disasters become increasingly frequent and more severe globally, people and organizations that prepare for and respond to these crises need efficient and effective ways to integrate sound science into their decision making. Experience has shown that integrating nongovernmental scientific expertise into disaster decision making can improve the quality of the response, and is most effective if the integration occurs before, during, and after a crisis, not just during a crisis. However, collaboration between academic, government, and industry scientists, decision makers, and responders is frequently difficult because of cultural differences, misaligned incentives, time pressures, and legal constraints. Our study addressed this challenge by using the Deep Change Method, a design methodology developed by Stanford ChangeLabs, which combines human-centered design, systems analysis, and behavioral psychology. We investigated underlying needs and motivations of government agency staff and academic scientists, mapped the root causes underlying the relationship failures between these two communities based on their experiences, and identified leverage points for shifting deeply rooted perceptions that impede collaboration. We found that building trust and creating mutual value between multiple stakeholders before crises occur is likely to increase the effectiveness of problem solving. We propose a solution, the Science Action Network, which is designed to address barriers to scientific collaboration by providing new mechanisms to build and improve trust and communication between government administrators and scientists, industry representatives, and academic scientists. The Science Action Network has the potential to ensure cross-disaster preparedness and science-based decision making through novel partnerships and scientific coordination.
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Designing a solution to enable agency-academic scientific collaboration for disasters
Mease, Lindley A.; Gibbs-Plessl, Theodora; Erickson, Ashley; Ludwig, Kristin A.; Reddy, Christopher M.; Lubchenco, Jane
2017-01-01
As large-scale environmental disasters become increasingly frequent and more severe globally, people and organizations that prepare for and respond to these crises need efficient and effective ways to integrate sound science into their decision making. Experience has shown that integrating nongovernmental scientific expertise into disaster decision making can improve the quality of the response, and is most effective if the integration occurs before, during, and after a crisis, not just during a crisis. However, collaboration between academic, government, and industry scientists, decision makers, and responders is frequently difficult because of cultural differences, misaligned incentives, time pressures, and legal constraints. Our study addressed this challenge by using the Deep Change Method, a design methodology developed by Stanford ChangeLabs, which combines human-centered design, systems analysis, and behavioral psychology. We investigated underlying needs and motivations of government agency staff and academic scientists, mapped the root causes underlying the relationship failures between these two communities based on their experiences, and identified leverage points for shifting deeply rooted perceptions that impede collaboration. We found that building trust and creating mutual value between multiple stakeholders before crises occur is likely to increase the effectiveness of problem solving. We propose a solution, the Science Action Network, which is designed to address barriers to scientific collaboration by providing new mechanisms to build and improve trust and communication between government administrators and scientists, industry representatives, and academic scientists. The Science Action Network has the potential to ensure cross-disaster preparedness and science-based decision making through novel partnerships and scientific coordination.
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Directory of Open Access Journals (Sweden)
Nathan P. Kettle
2014-01-01
Full Text Available Risk-based management approaches to climate adaptation depend on the assessment of potential threats, and their causes, vulnerabilities, and impacts. The refinement of these approaches relies heavily on detailed local knowledge of places and priorities, such as infrastructure, governance structures, and socio-economic conditions, as well as scientific understanding of climate projections and trends. Developing processes that integrate local and scientific knowledge will enhance the value of risk-based management approaches, facilitate group learning and planning processes, and support the capacity of communities to prepare for change. This study uses the Vulnerability, Consequences, and Adaptation Planning Scenarios (VCAPS process, a form of analytic-deliberative dialogue, and the conceptual frameworks of hazard management and climate vulnerability, to integrate scientific and local knowledge. We worked with local government staff in an urbanized barrier island community (Sullivan’s Island, South Carolina to consider climate risks, impacts, and adaptation challenges associated with sea level rise and wastewater and stormwater management. The findings discuss how the process increases understanding of town officials’ views of risks and climate change impacts to barrier islands, the management actions being considered to address of the multiple impacts of concern, and the local tradeoffs and challenges in adaptation planning. We also comment on group learning and specific adaptation tasks, strategies, and needs identified.
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Speech and scientific paper. A rhetorical approach
Directory of Open Access Journals (Sweden)
Juan Carlos Carmona Sandoval
2013-01-01
Full Text Available This essay attempts to show that the ancient rhetorical theory has explanatory capabilities to understand and learn to write modern texts and to analyze them in order to understand their communication skills, as in the scientific article, one of the most prestigious forms on scientific communication. It starts with the notion of discourse in the field of scientific communication and then address the rhetorical dimension of the paper.
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Scientific and technological assistance and the challenge of the 80's
Energy Technology Data Exchange (ETDEWEB)
Moravcsik, M J
1981-02-01
The US proposal for an Institute for Scientific and Technological Cooperation (ISTC) to aid developing countries could coordinate with new Third World development trends, which reflect attitudinal changes. This reassessment on the part of developing countries recognizes the relationship of appropriate scientific and technological infrastructures to long-term benefits and the need to promote indigenous leadership and personal development in order to rise above the status of welfare. This new approach will reduce political controversy, be less expensive, rely more on human than material resources, and emphasize the small scale. ISTC can integrate its actions with these trends by thinking in terms of building a broad infrastructure, avoiding country-specific projects, and operating directly through the scientific community. (DCK)
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GRACEnet: addressing policy needs through coordinated cross-location research
Jawson, Michael D.; Walthall, Charles W.; Shafer, Steven R.; Liebig, Mark; Franzluebbers, Alan J.; Follett, Ronald F.
2012-01-01
GRACEnet (Greenhouse gas Reduction through Agricultural Carbon Enhancement network) was conceived to build upon ongoing USDA Agricultural Research Service (ARS) research to improve soil productivity, while addressing the challenges and opportunities of interest in C sequestration from a climate change perspective. The vision for GRACEnet was and remains: Knowledge and information used to implement scientifically based agricultural management practices from the field to national policy scales on C sequestration, greenhouse gas (GHG) emissions, and environmental benefits. The national focus of GRACEnet uses a standardized approach by ARS laboratories and university and land manager (e.g. farmer and rancher) cooperators to assess C sequestration and GHG emission from different crop and grassland systems. Since 2002, GRACEnet has significantly expanded GHG mitigation science and delivered usable information to agricultural research and policy organizations. Recent developments suggest GRACEnet will have international impact by contributing leadership and technical guidance for the Global Research Alliance on Agricultural Greenhouse Gases.
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Women scientists reflections, challenges, and breaking boundaries
Hargittai, Magdolna
2015-01-01
Magdolna Hargittai uses over fifteen years of in-depth conversation with female physicists, chemists, biomedical researchers, and other scientists to form cohesive ideas on the state of the modern female scientist. The compilation, based on sixty conversations, examines unique challenges that women with serious scientific aspirations face. In addition to addressing challenges and the unjustifiable underrepresentation of women at the higher levels of academia, Hargittai takes a balanced approach by discussing how some of the most successful of these women have managed to obtain professional success and personal happiness. Women Scientists portrays scientists from different backgrounds, different geographical regions-eighteen countries from four continents-and leaders from a variety of professional backgrounds, including eight Nobel laureate women. The book is divided into three sections: "Husband and Wife Teams," "Women at the Top," and "In High Positions." Hargittai uses her own experience to introduce her fi...
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Strategies to address management challenges in larger intensive care units.
Matlakala, M C; Bezuidenhout, M C; Botha, A D H
2015-10-01
To illustrate the need for and suggest strategies that will enhance sustainable management of a large intensive care unit (ICU). The challenges faced by intensive care nursing in South Africa are well documented. However, there appear to be no strategies available to assist nurses to manage large ICUs or for ICU managers to deal with problems as they arise. Data sources to illustrate the need for strategies were challenges described by ICU managers in the management of large ICUs. A purposive sample of managers was included in individual interviews during compilation of evidence regarding the challenges experienced in the management of large ICUs. The challenges were presented at the Critical Care Society of Southern Africa Congress held on 28 August to 2 September 2012 in Sun City North-West province, South Africa. Five strategies are suggested for the challenges identified: divide the units into sections; develop a highly skilled and effective nursing workforce to ensure delivery of quality nursing care; create a culture to retain an effective ICU nursing team; manage assets; and determine the needs of ICU nurses. ICUs need measures to drive the desired strategies into actions to continuously improve the management of the unit. Future research should be aimed at investigating the effectiveness of the strategies identified. This research highlights issues relating to large ICUs and the strategies will assist ICU managers to deal with problems related to large unit sizes, shortage of trained ICU nurses, use of agency nurses, shortage of equipment and supplies and stressors in the ICU. The article will make a contribution to the body of nursing literature on management of ICUs. © 2014 John Wiley & Sons Ltd.
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Challenges associated with nerve conduction block using kilohertz electrical stimulation
Patel, Yogi A.; Butera, Robert J.
2018-06-01
Neuromodulation therapies, which electrically stimulate parts of the nervous system, have traditionally attempted to activate neurons or axons to restore function or alleviate disease symptoms. In stark contrast to this approach is inhibiting neural activity to relieve disease symptoms and/or restore homeostasis. One potential approach is kilohertz electrical stimulation (KES) of peripheral nerves—which enables a rapid, reversible, and localized block of conduction. This review highlights the existing scientific and clinical utility of KES and discusses the technical and physiological challenges that must be addressed for successful translation of KES nerve conduction block therapies.
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McPhaden, Michael; Leinen, Margaret; McEntee, Christine; Townsend, Randy; Williams, Billy
2016-04-01
The American Geophysical Union, a scientific society of 62,000 members worldwide, has established a set of scientific integrity and professional ethics guidelines for the actions of its members, for the governance of the union in its internal activities, and for the operations and participation in its publications and scientific meetings. This presentation will provide an overview of the Ethics program at AGU, highlighting the reasons for its establishment, the process of dealing ethical breaches, the number and types of cases considered, how AGU helps educate its members on Ethics issues, and the rapidly evolving efforts at AGU to address issues related to the emerging field of GeoEthics. The presentation will also cover the most recent AGU Ethics program focus on the role for AGU and other scientific societies in addressing sexual harassment, and AGU's work to provide additional program strength in this area.
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Resilient and Robust High Performance Computing Platforms for Scientific Computing Integrity
Energy Technology Data Exchange (ETDEWEB)
Jin, Yier [Univ. of Central Florida, Orlando, FL (United States)
2017-07-14
As technology advances, computer systems are subject to increasingly sophisticated cyber-attacks that compromise both their security and integrity. High performance computing platforms used in commercial and scientific applications involving sensitive, or even classified data, are frequently targeted by powerful adversaries. This situation is made worse by a lack of fundamental security solutions that both perform efficiently and are effective at preventing threats. Current security solutions fail to address the threat landscape and ensure the integrity of sensitive data. As challenges rise, both private and public sectors will require robust technologies to protect its computing infrastructure. The research outcomes from this project try to address all these challenges. For example, we present LAZARUS, a novel technique to harden kernel Address Space Layout Randomization (KASLR) against paging-based side-channel attacks. In particular, our scheme allows for fine-grained protection of the virtual memory mappings that implement the randomization. We demonstrate the effectiveness of our approach by hardening a recent Linux kernel with LAZARUS, mitigating all of the previously presented side-channel attacks on KASLR. Our extensive evaluation shows that LAZARUS incurs only 0.943% overhead for standard benchmarks, and is therefore highly practical. We also introduced HA2lloc, a hardware-assisted allocator that is capable of leveraging an extended memory management unit to detect memory errors in the heap. We also perform testing using HA2lloc in a simulation environment and find that the approach is capable of preventing common memory vulnerabilities.
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Stjepandic, J; Verhagen, W.J.C.; Wognum, P.M.
2015-01-01
CE has been used for more than two decades now. Despite many successes and advantages, there are still many challenges to be addressed. These challenges are both technical and organisational. In the paper we will address the current challenges of CE. Many challenges
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Richter-Sundberg, Linda; Kardakis, Therese; Weinehall, Lars; Garvare, Rickard; Nyström, Monica E
2015-01-22
Many of the world's life threatening diseases (e.g. cancer, heart disease, stroke) could be prevented by eliminating life-style habits such as tobacco use, unhealthy diet, physical inactivity and excessive alcohol use. Incorporating evidence-based research on methods to change unhealthy lifestyle habits in clinical practice would be equally valuable. However gaps between guideline development and implementation are well documented, with implications for health care quality, safety and effectiveness. The development phase of guidelines has been shown to be important both for the quality in guideline content and for the success of implementation. There are, however, indications that guidelines related to general disease prevention methods encounter specific barriers compared to guidelines that are diagnosis-specific. In 2011 the Swedish National board for Health and Welfare launched guidelines with a preventive scope. The aim of this study was to investigate how implementation challenges were addressed during the development process of these disease preventive guidelines. Seven semi-structured interviews were conducted with members of the guideline development management group. Archival data detailing the guideline development process were also collected and used in the analysis. Qualitative data were analysed using content analysis as the analytical framework. The study identified several strategies and approaches that were used to address implementation challenges during guideline development. Four themes emerged from the analysis: broad agreements and consensus about scope and purpose; a formalized and structured development procedure; systematic and active involvement of stakeholders; and openness and transparency in the specific guideline development procedure. Additional factors concerning the scope of prevention and the work environment of guideline developers were perceived to influence the possibilities to address implementation issues. This case study
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Cak, A. D.; Vigdor, L. J.; Vorosmarty, C. J.; Giebel, B. M.; Santistevan, C.; Chasteau, C.
2017-12-01
Tackling emergent, societally-relevant problems in the environmental sciences is hardly confined to a single research discipline, but rather requires collaborations that bridge diverse domains and perspectives. While new technologies (e.g., Skype) can in theory unite otherwise geographically distributed participation in collaborative research, physical distance nevertheless raises the bar on intellectual dialogue. Such barriers may reveal perceptions of or real differences across disciplines, reflecting particular traditions in their histories and academic cultures. Individual disciplines are self-defined by their scientific, epistemologic, methodologic, or philosophical traditions (e.g., difficulties in understanding processes occurring at different scales, insufficient research funding for interdisciplinary work), or cultural and discursive hurdles (e.g., navigating a new field's jargon). Coupled with these challenges is a considerable deficiency in educating the next generation of scientists to help them develop a sufficient comfort level with thinking critically across multiple disciplinary domains and conceptual frameworks. To address these issues, the City University of New York (CUNY), the largest public urban university in the U.S., made a significant investment in advancing cross-disciplinary research and education, culminating in the opening of the CUNY Advanced Science Research Center (ASRC) in New York City (NYC) in late 2014. We report here on our experiences incubating new collaborative efforts to address environmental science-related research as it is interwoven with the ASRC's five research initiatives (Environmental Sciences, Neuroscience, Structural Biology, Photonics, and Nanoscience). We describe the ASRC's overall structure and function as both a stand-alone interdisciplinary center and one that collaborates more broadly with CUNY's network of twenty-four campuses distributed across NYC's five boroughs. We identify challenges we have faced so
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Craddock, Jaih B.
2017-01-01
The aim of this article is to address some of the questions Dr. Paula S. Nurius presents in her article, "Innovation and Emerging Scientific Careers: Is Social Work Prepared to Compete in Today?s Scientific Marketplace?" Specifically, this article will focus on what we can do to better prepare our emerging research scholars to be…
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Beyond 2013 - The Future of European Scientific Drilling Research - An introduction.
Camoin, G.; Stein, R.
2009-04-01
The Integrated Ocean Drilling Program (IODP) is funded for the period 2003-2013, and is now starting to plan the future of ocean drilling beyond 2013, including the development of new technologies, new emerging research fields as and the societal relevance of this programme. In this context an interdisciplinary and multinational (USA, Europe, Japan, Asian and Oceanian countries), key conference - INVEST IODP New Ventures in Exploring Scientific Targets - addressing all international IODP partners is therefore planned for September 23rd-25th 2009 in Bremen, Germany (more information at http://www.iodp.org and http://marum.de/iodp-invest.html) to discuss future directions of ocean drilling research and related aspects such as ventures with related programmes or with industry. The first critical step of INVEST is to define the scientific research goals of the second phase of the Integrated Ocean Drilling Program (IODP), which is expected to begin in late 2013. INVEST will be open to all interested scientists and students and will be the principal opportunity for the international science community to help shape the future of scientific ocean drilling. The outcome of the conference will be the base to draft a science plan in 2010 and to define new goals and strategies to effectively meet the challenges of society and future ocean drilling. The current EGU Session and the related two days workshop which will be held at the University of Vienna will specifically address the future of European scientific drilling research. The major objectives of those two events are to sharpen the European interests in the future IODP and to prepare the INVEST Conference and are therefore of prime importance to give weight to the European propositions in the program renewal processes, both on science, technology and management, and to provide the participants with information about the status/process of ongoing discussions and negotiations regarding program structure, and provide them
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Mburu, Grace; George, Gavin
2017-07-31
Shortages of Human Resources for Health (HRH) in rural areas are often driven by poor working and living conditions, inadequate salaries and benefits, lack of training and career development opportunities amongst others. The South African government has adopted a human resource strategy for the health sector in 2011 aimed at addressing these challenges. This study reviews the challenges faced by health personnel against government strategies aimed at attracting and retaining health personnel in these underserved areas. The study was conducted in six primary health care service sites in the Hlabisa sub-district of Umkhanyakude, located in northern KwaZulu-Natal, South Africa. The study population comprised 25 health workers including 11 professional nurses, 4 staff nurses and 10 doctors (4 medical doctors, 3 foreign medical doctors and 3 doctors undertaking community service). Qualitative data were collected from semi-structured interviews and analysed using thematic analysis. Government initiatives including the rural allowance, deployment of foreign medical doctors and the presence of health personnel undertaking their community service in rural areas are positively viewed by health personnel working in rural health facilities. However, poor living and working conditions, together with inadequate personal development opportunities, remain unresolved challenges. It is these challenges that will continue to dissuade experienced health personnel from remaining in these underserved areas. South Africa's HRH strategy for the Health Sector 2012/13-2015/16 had highlighted the key challenges raised by respondents and identified strategies aimed at addressing these challenges. Implementation of these strategies is key to improving both living and working conditions, and providing health personnel with opportunities for further development will require inter-ministerial collaboration if the HRH 2030 objectives are to be realised.
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Expanding the Role for Psychology in Addressing Environmental Challenges
Clayton, Susan; Devine-Wright, Patrick; Swim, Janet; Bonnes, Mirilia; Steg, Linda; Whitmarsh, Lorraine; Carrico, Amanda
Environmental challenges, though daunting, present an important area for psychologists to apply their knowledge. Psychological theories, research methods, and interventions are essential for examining the questions about human impacts, tendencies, and capacities that are integral to constructing
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Geddie, Hannah; Dobrow, Mark J; Hoch, Jeffrey S; Rabeneck, Linda
2012-06-01
releases, and correspondence. Interviews will be conducted in person with senior administrative leaders, government officials, screening experts, and high-level cancer system stakeholders. The proposed study comprises the third and final phase of an Emerging Team grant to address the challenges of health-policy decision making and colorectal cancer screening decisions in Canada. This study will contribute a unique prospective look at how policy makers address new, emerging scientific evidence in several different policy environments and at different stages of program planning and implementation. Findings will provide important insight into the various approaches that are or should be used to monitor emerging evidence, the relative importance of scientific versus contextual evidence for decision making, and the tools and processes that may be important to support challenging health-policy decisions.
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Can pervasive sensing address current challenges in global healthcare?
Directory of Open Access Journals (Sweden)
Louis Atallah
2012-03-01
Full Text Available Important challenges facing global healthcare include the increase in the number of people affected by escalating healthcare costs, chronic and infectious diseases, the need for better and more affordable elderly care and expanding urbanisation combined with air and water pollution. Recent advances in pervasive sensing technologies have led to miniaturised sensor networks that can be worn or integrated within the living environment without affecting a person’s daily patterns. These sensors promise to change healthcare from snapshot measurements of physiological parameters to continuous monitoring enabling clinicians to provide guidance on a daily basis. This article surveys several of the solutions provided by these sensor platforms from elderly care to neonatal monitoring and environmental mapping. Some of the opportunities available and the challenges facing the adoption of such technologies in large-scale epidemiological studies are also discussed.
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DEFF Research Database (Denmark)
Louw, Arnt Vestergaard
The findings of the expert group detail the role of youth work and its specific contribution to addressing the challenges young people face, in particular the transition from education to employment. In this context, youth work is defined as 'actions directed towards young people regarding activi...... activities where they take part voluntarily, designed for supporting their personal and social development through non-formal and informal learning'....
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Energy Technology Data Exchange (ETDEWEB)
Viollet, Pierre-Louis; Roult, Didier; Mathex, Bruno; Ouaabi, Aziz; Louis, Frederic; Petitjean, Alain; Capuozzo, Vincent; Mazzouji, Farid; Prestat, Bruno; Nekrassov, Andrei; Caignaert, Guy; Vidil, Roland; Guilbaud, Claude; Metais, Olivier
2011-11-15
This document briefly synthesizes a conference which addressed the development of pumped storage power plants in the world, and social, economic, technical and scientific challenges related to this development which is closely related to the development of intermittent renewable energies (wind and solar energy). Current developments in different countries (Germany, Portugal, Switzerland, Norway, France and China) are evoked
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Wu, Yelena P; Steele, Ric G; Connelly, Mark A; Palermo, Tonya M; Ritterband, Lee M
2014-07-01
To provide an overview of common challenges that pediatric eHealth researchers may encounter when planning, developing, testing, and disseminating eHealth interventions along with proposed solutions for addressing these challenges. The article draws on the existing eHealth literature and the authors' collective experience in pediatric eHealth research. The challenges associated with eHealth interventions and their proposed solutions are multifaceted and cut across a number of areas from eHealth program development through dissemination. Collaboration with a range of individuals (e.g., multidisciplinary colleagues, commercial entities, primary stakeholders) is the key to eHealth intervention success. To ensure adequate resources for design, development, and planning for sustainability, a number of public and private sources of funding are available. A study design that addresses ethical concerns and security issues is critical to ensure scientific integrity and intervention dissemination. Table I summarizes key issues to consider during eHealth intervention development, testing, and dissemination. © The Author 2014. Published by Oxford University Press on behalf of the Society of Pediatric Psychology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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Addressing challenges in bar-code scanning of large-volume infusion bags.
Raman, Kirthana; Heelon, Mark; Kerr, Gary; Higgins, Thomas L
2011-08-01
A hospital pharmacy's efforts to identify and address challenges with bedside scanning of bar codes on large-volume parenteral (LVP) infusion bags are described. Bar-code-assisted medication administration (BCMA) has been shown to reduce medication errors and improve patient safety. After the pilot implementation of a BCMA system and point-of-care scanning procedures at a medical center's intensive care unit, it was noted that nurses' attempted bedside scans of certain LVP bags for product identification purposes often were not successful. An investigation and root-cause analysis, including observation of nurses' scanning technique by a multidisciplinary team, determined that the scanning failures stemmed from the placement of two bar-code imprints-one with the product identification code and another, larger imprint with the expiration date and lot number-adjacently on the LVP bags. The nursing staff was educated on a modified scanning technique, which resulted in significantly improved success rates in the scanning of the most commonly used LVP bags. Representatives of the LVP bag manufacturer met with hospital staff to discuss the problem and corrective measures. As part of a subsequent infusion bag redesign, the manufacturer discontinued the use of the bar-code imprint implicated in the scanning failures. Failures in scanning LVP bags were traced to problematic placement of bar-code imprints on the bags. Interdisciplinary collaboration, consultation with the bag manufacturer, and education of the nursing and pharmacy staff resulted in a reduction in scanning failures and the manufacturer's removal of one of the bar codes from its LVP bags.
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Scientific Opportunity to Reduce Risk in Groundwater and Soil Remediation
Energy Technology Data Exchange (ETDEWEB)
Pierce, Eric M.; Freshley, Mark D.; Hubbard, Susan S.; Looney, Brian B.; Zachara, John M.; Liang, Liyuan; Lesmes, D.; Chamberlain, G. M.; Skubal, Karen L.; Adams, V.; Denham, Miles E.; Wellman, Dawn M.
2009-08-25
In this report, we start by examining previous efforts at linking science and DOE EM research with cleanup activities. Many of these efforts were initiated by creating science and technology roadmaps. A recurring feature of successfully implementing these roadmaps into EM applied research efforts and successful cleanup is the focus on integration. Such integration takes many forms, ranging from combining information generated by various scientific disciplines, to providing technical expertise to facilitate successful application of novel technology, to bringing the resources and creativity of many to address the common goal of moving EM cleanup forward. Successful projects identify and focus research efforts on addressing the problems and challenges that are causing “failure” in actual cleanup activities. In this way, basic and applied science resources are used strategically to address the particular unknowns that are barriers to cleanup. The brief descriptions of the Office of Science basic (Environmental Remediation Science Program [ERSP]) and EM’s applied (Groundwater and Soil Remediation Program) research programs in subsurface science provide context to the five “crosscutting” themes that have been developed in this strategic planning effort. To address these challenges and opportunities, a tiered systematic approach is proposed that leverages basic science investments with new applied research investments from the DOE Office of Engineering and Technology within the framework of the identified basic science and applied research crosscutting themes. These themes are evident in the initial portfolio of initiatives in the EM groundwater and soil cleanup multi-year program plan. As stated in a companion document for tank waste processing (Bredt et al. 2008), in addition to achieving its mission, DOE EM is experiencing a fundamental shift in philosophy from driving to closure to enabling the long-term needs of DOE and the nation.
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Hsu, Pei-Ling
2018-05-01
Internships in science research settings have received increasing attention as a means of helping students construct appropriate understandings, practices, tools, and language in scientific activities. To advance student-scientist partnerships beyond the status quo, the study aimed to investigate how cogenerative dialogs (cogens) may help high school students and scientists identify and address challenges collectively. The analysis identified nine major challenges discussed during cogens: (1) the quality and progress of scientific practice in laboratories, (2) the quality of scientists'/assistants' instructions in classrooms, (3) the quality of student participation in classrooms and homework, (4) students' absences, including arriving late or leaving early, (5) the quality of administrative support, (6) preparation for scientific presentations, (7) the process of deciding project topics, (8) students' peer interactions and communication, and (9) students' physiological needs. The three most salient challenges were "the quality and progress of scientific practice in laboratories" (39%), "the quality of scientists'/assistants' instructions in classrooms" (20%), and "the quality of student participation in classrooms and homework" (17%). The study shows that cogens allowed students and scientists to agree on teaching modifications that positively influenced teaching and learning processes during the internship, such that issues were reduced from the beginning to the closing stages. Importantly, the challenges and solutions identified by students and scientists in this study provide accounts of first-hand experience as well as insights to aid program directors or coordinators in designing a learning environment that can foster effective practice for internships by avoiding the issues identified in the study.
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Directory of Open Access Journals (Sweden)
Sekandi Juliet
2011-03-01
Full Text Available Abstract Background Mulago National Referral Hospital (MNRH, Uganda’s primary tertiary and teaching hospital, and Makerere University College of Health Sciences (MakCHS have a close collaborative relationship. MakCHS students complete clinical rotations at MNRH, and MakCHS faculty partner with Mulago staff in clinical care and research. In 2009, as part of a strategic planning process, MakCHS undertook a qualitative study to examine care and service provision at MNRH, identify challenges, gaps, and solutions, and explore how MakCHS could contribute to improving care and service delivery at MNRH. Methods Key informant interviews (n=23 and focus group discussions (n=7 were conducted with nurses, doctors, administrators, clinical officers and other key stakeholders. Interviews and focus groups were tape recorded and transcribed verbatim, and findings were analyzed through collaborative thematic analysis. Results Challenges to care and service delivery at MNRH included resource constraints (staff, space, equipment, and supplies, staff inadequacies (knowledge, motivation, and professionalism, overcrowding, a poorly functioning referral system, limited quality assurance, and a cumbersome procurement system. There were also insufficiencies in the teaching of professionalism and communication skills to students, and patient care challenges that included lack of access to specialized services, risk of infections, and inappropriate medications. Suggestions for how MakCHS could contribute to addressing these challenges included strengthening referral systems and peripheral health center capacity, and establishing quality assurance mechanisms. The College could also strengthen the teaching of professionalism, communication and leadership skills to students, and monitor student training and develop courses that contribute to continuous professional development. Additionally, the College could provide in-service education for providers on professionalism
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Energy Technology Data Exchange (ETDEWEB)
Maingi, Rajesh [Princeton Plasma Physics Lab. (PPPL), Princeton, NJ (United States); Zinkle, Steven J. [University of Tennessee â Knoxville; Foster, Mark S. [U.S. Department of Energy
2015-05-01
The realization of controlled thermonuclear fusion as an energy source would transform society, providing a nearly limitless energy source with renewable fuel. Under the auspices of the U.S. Department of Energy, the Fusion Energy Sciences (FES) program management recently launched a series of technical workshops to “seek community engagement and input for future program planning activities” in the targeted areas of (1) Integrated Simulation for Magnetic Fusion Energy Sciences, (2) Control of Transients, (3) Plasma Science Frontiers, and (4) Plasma-Materials Interactions aka Plasma-Materials Interface (PMI). Over the past decade, a number of strategic planning activities1-6 have highlighted PMI and plasma facing components as a major knowledge gap, which should be a priority for fusion research towards ITER and future demonstration fusion energy systems. There is a strong international consensus that new PMI solutions are required in order for fusion to advance beyond ITER. The goal of the 2015 PMI community workshop was to review recent innovations and improvements in understanding the challenging PMI issues, identify high-priority scientific challenges in PMI, and to discuss potential options to address those challenges. The community response to the PMI research assessment was enthusiastic, with over 80 participants involved in the open workshop held at Princeton Plasma Physics Laboratory on May 4-7, 2015. The workshop provided a useful forum for the scientific community to review progress in scientific understanding achieved during the past decade, and to openly discuss high-priority unresolved research questions. One of the key outcomes of the workshop was a focused set of community-initiated Priority Research Directions (PRDs) for PMI. Five PRDs were identified, labeled A-E, which represent community consensus on the most urgent near-term PMI scientific issues. For each PRD, an assessment was made of the scientific challenges, as well as a set of actions
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Re-embedding scientific development in the realities of local communities
DEFF Research Database (Denmark)
Mortensen, Jonas Egmose; Eames, Malcolm; Nielsen, Kurt Aagaard
As the effects of climate change is becoming increasingly visible scientific and technological development is often seen as a key component in political action towards future sustainability. Historically, however, it is not evident that science and technology per se lead to sustainable solutions....... To address this aspect of the challenge of sustainable development, this paper examines whether new approaches to upstream engagement in science and technology can further knowledge channels between academia and local communities, which can inspire more contextualised modes of knowledge production. Building...... on the insights from critical theory; newer conceptualisations of knowledge production; and the experiences from the Citizen Science for Sustainability action research programme, a number of principles towards more reflexive forms of community based public engagement in science and technology are proposed....
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A strategy to address the nursing faculty shortage.
Ganley, Barbara J; Sheets, Ingrid
2009-07-01
This article describes one university's experience in creating a master's geriatric clinical nurse specialist-nurse educator program to address the nursing faculty shortage and the need for geriatric clinical nurse specialists. The successes and challenges are outlined, and curricular ideas that may be beneficial to other nursing programs also are presented. This program has enhanced the university's pool of clinical instructors, increased its ability to provide services to older adults, and allowed faculty to instruct and focus undergraduates in the distinctions of geriatric nursing care. The biggest challenges faced were marketing and recruitment of nurses; these challenges were addressed, and possible solutions are offered. The most immediate benefit of this program was the generation of geriatric clinical nurse specialists.
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Design and manufacturing challenges of optogenetic neural interfaces: a review
Goncalves, S. B.; Ribeiro, J. F.; Silva, A. F.; Costa, R. M.; Correia, J. H.
2017-08-01
Optogenetics is a relatively new technology to achieve cell-type specific neuromodulation with millisecond-scale temporal precision. Optogenetic tools are being developed to address neuroscience challenges, and to improve the knowledge about brain networks, with the ultimate aim of catalyzing new treatments for brain disorders and diseases. To reach this ambitious goal the implementation of mature and reliable engineered tools is required. The success of optogenetics relies on optical tools that can deliver light into the neural tissue. Objective/Approach: Here, the design and manufacturing approaches available to the scientific community are reviewed, and current challenges to accomplish appropriate scalable, multimodal and wireless optical devices are discussed. Significance: Overall, this review aims at presenting a helpful guidance to the engineering and design of optical microsystems for optogenetic applications.
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Avril, B.; et al.
2012-04-01
The "Responses to Environmental and Societal Challenges for our Unstable Earth" (RESCUE; www.esf.org/rescue) foresight initiative - a joint COST-ESF "Frontiers of Science" initiative - aimed to help Europe address the societal and scientific challenges related to global environmental change and the related resilience issues. In RESCUE, the focus of attention was on people and the goal was to stimulate an integrated, innovative response from natural, social and human sciences. The RESCUE foresight initiative began in September 2009 and has recently been completed. RESCUE had the following key objectives: 1. To propose a strategic process for natural, social and human sciences to improve their ability and capacity to work together to address global environmental change through interdisciplinary synergy and to respond effectively to societal and policy-relevant needs; 2. To articulate new scientific issues related to global environmental change and the related resilience issues, especially those of transdisciplinary nature and of major relevance to society; 3. To explore new approaches towards truly integrated, interdisciplinary science, and to facilitate the 'revolution' in education and capacity building it requires. The work of RESCUE focused on the following themes: · Contributions from social sciences and humanities in developing responses to challenges of the Anthropocene; · Collaboration between the natural, social and human sciences in global environmental change and resilience studies; · Requirements for research methodologies and data; · Education and capacity building - towards a 'revolution'; · The interface between science and policy, communication and outreach. The RESCUE recommendations include the following issues to be addressed by science-funders, science policy-makers, researchers, practitioners, educators and a range of other societal actors: · develop an institutional framework for an open knowledge society, · re-organise research so
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Directory of Open Access Journals (Sweden)
Roland Clift
2017-02-01
Full Text Available The Planetary Boundaries (PB framework represents a significant advance in specifying the ecological constraints on human development. However, to enable decision-makers in business and public policy to respect these constraints in strategic planning, the PB framework needs to be developed to generate practical tools. With this objective in mind, we analyse the recent literature and highlight three major scientific and technical challenges in operationalizing the PB approach in decision-making: first, identification of thresholds or boundaries with associated metrics for different geographical scales; second, the need to frame approaches to allocate fair shares in the ‘safe operating space’ bounded by the PBs across the value chain and; third, the need for international bodies to co-ordinate the implementation of the measures needed to respect the Planetary Boundaries. For the first two of these challenges, we consider how they might be addressed for four PBs: climate change, freshwater use, biosphere integrity and chemical pollution and other novel entities. Four key opportunities are identified: (1 development of a common system of metrics that can be applied consistently at and across different scales; (2 setting ‘distance from boundary’ measures that can be applied at different scales; (3 development of global, preferably open-source, databases and models; and (4 advancing understanding of the interactions between the different PBs. Addressing the scientific and technical challenges in operationalizing the planetary boundaries needs be complemented with progress in addressing the equity and ethical issues in allocating the safe operating space between companies and sectors.
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Doing Science that Matters to Address India's Water Crisis.
Srinivasan, V.
2017-12-01
Addressing water security in developing regions involves predicting water availability under unprecedented rates of population and economic growth. India is one of the most water stressed countries in the world. Despite appreciable increases in funding for water research, high quality science that is usable by stakeholders remains elusive. The absence of usable research, has been driven by notions of what is publishable in the developed world. This can be attributed to the absence of problem driven research on questions that actually matter to stakeholders, unwillingness to transcend disciplinary boundaries and the demise of a field-work research culture in favour of computer simulation. Yet the combination of rapid change, inadequate data and human modifications to watersheds poses a challenge, as researchers face a poorly constrained water resources modelling problem. Instead, what India and indeed all developing regions need is to approach the problem from first principles, identifying the most critical knowledge gaps, then prioritizing data collection using novel sensing and modelling approaches to address them. This might also necessitate consideration of underlying social and governance drivers of hydrologic change. Using examples from research in the Cauvery Basin, a highly contentious inter-state river basin, I offer some insights into framing "use-inspired" research agenda and show how the research generates not just new scientific insights but may be translated into practice.
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The Big Five: Addressing Recurrent Multimodal Learning Data Challenges
Di Mitri, Daniele; Schneider, Jan; Specht, Marcus; Drachsler, Hendrik
2018-01-01
The analysis of multimodal data in learning is a growing field of research, which has led to the development of different analytics solutions. However, there is no standardised approach to handle multimodal data. In this paper, we describe and outline a solution for five recurrent challenges in
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Adherence to Scientific Method while Advancing Exposure Science
Paul Lioy was simultaneously a staunch adherent to the scientific method and an innovator of new ways to conduct science, particularly related to human exposure. Current challenges to science and the application of the scientific method are presented as they relate the approaches...
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Technical Challenges and Scientific Payoffs of Muon Beam Accelerators for Particle Physics
International Nuclear Information System (INIS)
Zisman, Michael S.
2007-01-01
Historically, progress in particle physics has largely been determined by development of more capable particle accelerators. This trend continues today with the recent advent of high-luminosity electron-positron colliders at KEK and SLAC operating as 'B factories', the imminent commissioning of the Large Hadron Collider at CERN, and the worldwide development effort toward the International Linear Collider. Looking to the future, one of the most promising approaches is the development of muon-beam accelerators. Such machines have very high scientific potential, and would substantially advance the state-of-the-art in accelerator design. A 20-50 GeV muon storage ring could serve as a copious source of well-characterized electron neutrinos or antineutrinos (a Neutrino Factory), providing beams aimed at detectors located 3000-7500 km from the ring. Such long baseline experiments are expected to be able to observe and characterize the phenomenon of charge-conjugation-parity (CP) violation in the lepton sector, and thus provide an answer to one of the most fundamental questions in science, namely, why the matter-dominated universe in which we reside exists at all. By accelerating muons to even higher energies of several TeV, we can envision a Muon Collider. In contrast with composite particles like protons, muons are point particles. This means that the full collision energy is available to create new particles. A Muon Collider has roughly ten times the energy reach of a proton collider at the same collision energy, and has a much smaller footprint. Indeed, an energy frontier Muon Collider could fit on the site of an existing laboratory, such as Fermilab or BNL. The challenges of muon-beam accelerators are related to the facts that (1) muons are produced as a tertiary beam, with very large 6D phase space, and (2) muons are unstable, with a lifetime at rest of only 2 microseconds. How these challenges are accommodated in the accelerator design will be described. Both a
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National Research Council Canada - National Science Library
Johnson, Carl
1999-01-01
.... The purpose of this research paper is to answer the question, Is the Army's current leadership model and leader development doctrine properly addressing the challenges brought about by the transition to Force XXI...
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Directory of Open Access Journals (Sweden)
Joseph P. Kenny
2008-01-01
Full Text Available Cutting-edge scientific computing software is complex, increasingly involving the coupling of multiple packages to combine advanced algorithms or simulations at multiple physical scales. Component-based software engineering (CBSE has been advanced as a technique for managing this complexity, and complex component applications have been created in the quantum chemistry domain, as well as several other simulation areas, using the component model advocated by the Common Component Architecture (CCA Forum. While programming models do indeed enable sound software engineering practices, the selection of programming model is just one building block in a comprehensive approach to large-scale collaborative development which must also address interface and data standardization, and language and package interoperability. We provide an overview of the development approach utilized within the Quantum Chemistry Science Application Partnership, identifying design challenges, describing the techniques which we have adopted to address these challenges and highlighting the advantages which the CCA approach offers for collaborative development.
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Siddiqi, Afreen; Stoppani, Jonathan; Anadon, Laura Diaz; Narayanamurti, Venkatesh
2016-01-01
patterns of stagnation and contraction of scientific activity for several MENA countries contributing to a widening productivity gap on an international comparative yardstick. The results prompt questions about the strength of the developing scientific enterprise and highlight the need for consistent long-term policy for effectively addressing regional challenges with domestic research.
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Patel, Minal R.; Caldwell, Cleopatra H.; Id-Deen, Effat; Clark, Noreen M.
2018-01-01
Objective Despite economic hardship, compliance with self-management regimens is still evident among individuals and families managing chronic disease. The purpose of this study was to describe how women with asthma address cost-related challenges to management of their condition. Methods In 2012 and 2013, four focus groups were conducted in Southeast Michigan with 26 African American women with asthma, recruited based on maximum variation sampling procedures. A semi-structured interview protocol was employed by trained facilitators. Coded transcripts were analyzed for themes regarding means to reduce the impact of the cost of asthma management. Results Major themes identified were acceptance of the status quo; stockpiling and sharing medicines; utilizing community assistance programs; reaching out to healthcare providers and social networks for help; foregoing self-management; and utilizing urgent care. Conclusions Awareness of strategies that are helpful to patients in reducing out-of-pocket costs may better equip service providers and others to develop interventions to make useful strategies more widely available. PMID:24471517
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Patel, Minal R; Caldwell, Cleopatra H; Id-Deen, Effat; Clark, Noreen M
2014-06-01
Despite economic hardship, compliance with self-management regimens is still evident among individuals and families managing chronic disease. The purpose of this study was to describe how women with asthma address cost-related challenges to management of their condition. In 2012 and 2013, four focus groups were conducted in Southeast Michigan with 26 African American women with asthma, recruited based on maximum variation sampling procedures. A semi-structured interview protocol was employed by trained facilitators. Coded transcripts were analyzed for themes regarding means to reduce the impact of the cost of asthma management. Major themes identified were acceptance of the status quo; stockpiling and sharing medicines; utilizing community assistance programs; reaching out to healthcare providers and social networks for help; foregoing self-management; and utilizing urgent care. Awareness of strategies that are helpful to patients in reducing out-of-pocket costs may better equip service providers and others to develop interventions to make useful strategies more widely available.
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Scientific impact: opportunity and necessity.
Cohen, Marlene Z; Alexander, Gregory L; Wyman, Jean F; Fahrenwald, Nancy L; Porock, Davina; Wurzbach, Mary E; Rawl, Susan M; Conn, Vicki S
2010-08-01
Recent National Institutes of Health changes have focused attention on the potential scientific impact of research projects. Research with the excellent potential to change subsequent science or health care practice may have high scientific impact. Only rigorous studies that address highly significant problems can generate change. Studies with high impact may stimulate new research approaches by changing understanding of a phenomenon, informing theory development, or creating new research methods that allow a field of science to move forward. Research with high impact can transition health care to more effective and efficient approaches. Studies with high impact may propel new policy developments. Research with high scientific impact typically has both immediate and sustained influence on the field of study. The article includes ideas to articulate potential scientific impact in grant applications as well as possible dissemination strategies to enlarge the impact of completed projects.
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Trends, Challenges, and Opportunities Regarding Research in Non-traumatic Spinal Cord Dysfunction
DEFF Research Database (Denmark)
New, Peter Wayne; Guilcher, Sara J T; Jaglal, Susan B
2017-01-01
collection; and (c) funding, preclinical, and international research. Opportunities for addressing these were identified. Conclusions: The increase in scientific publications on SCDys highlights the importance of this heterogeneous group among the research community. The overall lack of good quality......Background: Spinal cord dysfunction (SCDys) is caused by heterogeneous health conditions, and the incidence is increasing. Despite the growing interest in rehabilitation research for SCDys, research into SCDys faces many challenges. Objective: The objective of this project was to perform a clinical...... review of changes in SCDys research over the last 4 decades; identify challenges to conducting research in SCDys; and propose opportunities for improving research in SCDys. Methods: A triangulation approach was used for obtaining evidence: literature search (January 2017) using MEDLINE and Embase...
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SDM center technologies for accelerating scientific discoveries
International Nuclear Information System (INIS)
Shoshani, Arie; Altintas, Ilkay; Choudhary, Alok; Critchlow, Terence; Kamath, Chandrika; Ludaescher, Bertram; Nieplocha, Jarek; Parker, Steve; Ross, Rob; Samatova, Nagiza; Vouk, Mladen
2007-01-01
With the increasing volume and complexity of data produced by ultra-scale simulations and high-throughput experiments, understanding the science is largely hampered by the lack of comprehensive, end-to-end data management solutions ranging from initial data acquisition to final analysis and visualization. The SciDAC-1 Scientific Data Management (SDM) Center succeeded in bringing an initial set of advanced data management technologies to DOE application scientists in astrophysics, climate, fusion, and biology. Equally important, it established collaborations with these scientists to better understand their science as well as their forthcoming data management and data analytics challenges. Our future focus is on improving the SDM framework to address the needs of ultra-scale science during SciDAC-2. Specifically, we are enhancing and extending our existing tools to allow for more interactivity and fault tolerance when managing scientists' workflows, for better parallelism and feature extraction capabilities in their data analytics operations, and for greater efficiency and functionality in users' interactions with local parallel file systems, active storage, and access to remote storage. These improvements are necessary for the scalability and complexity challenges presented by hardware and applications at ultra scale, and are complemented by continued efforts to work with application scientists in various domains
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Haseeb, Shariq; Hashim, Aisha Hassan A.; Khalifa, Othman O.; Faris Ismail, Ahmad
2017-11-01
IoT aims to interconnect sensors and actuators built into devices (also known as Things) in order for them to share data and control each other to improve existing processes for making people’s life better. IoT aims to connect between all physical devices like fridges, cars, utilities, buildings and cities so that they can take advantage of small pieces of information collected by each one of these devices and derive more complex decisions. However, these devices are heterogeneous in nature because of various vendor support, connectivity options and protocol suit. Heterogeneity of such devices makes it difficult for them to leverage on each other’s capabilities in the traditional IoT architecture. This paper highlights the effects of heterogeneity challenges on connectivity, interoperability, management in greater details. It also surveys some of the existing solutions adopted in the core network to solve the challenges of massive IoT deployments. Finally, the paper proposes a new architecture based on NFV to address the problems.
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Addressing the challenges of postgraduate supervision to meet the ...
African Journals Online (AJOL)
By 2030 South Africa has set the sites on producing 100 doctorate graduates per one million people. This means an increase from 1420 doctoral degrees from 2010 to 5000 doctoral degrees to 2030. The researcher concerns are on the various challenges experienced by students presently and the impact it is having on ...
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Oral health in Libya: addressing the future challenges | Peeran ...
African Journals Online (AJOL)
Libya is a vast country situated in North Africa, having a relatively better functioning economy with a scanty population. This article is the first known attempt to review the current state of oral health care in Libya and to explore the present trends and future challenges. Libyan health system, oral health care, and human ...
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Scientific challenges in sustainable energy technology
Lewis, Nathan
2006-04-01
We describe and evaluate the technical, political, and economic challenges involved with widespread adoption of renewable energy technologies. First, we estimate fossil fuel resources and reserves and, together with the current and projected global primary power production rates, estimate the remaining years of oil, gas, and coal. We then compare the conventional price of fossil energy with that from renewable energy technologies (wind, solar thermal, solar electric, biomass, hydroelectric, and geothermal) to evaluate the potential for a transition to renewable energy in the next 20-50 years. Secondly, we evaluate - per the Intergovernmental Panel on Climate Change - the greenhouse constraint on carbon-based power consumption as an unpriced externality to fossil-fuel use, considering global population growth, increased global gross domestic product, and increased energy efficiency per unit GDP. This constraint is projected to drive the demand for carbon-free power well beyond that produced by conventional supply/demand pricing tradeoffs, to levels far greater than current renewable energy demand. Thirdly, we evaluate the level and timescale of R&D investment needed to produce the required quantity of carbon-free power by the 2050 timeframe. Fourth, we evaluate the energy potential of various renewable energy resources to ascertain which resources are adequately available globally to support the projected demand. Fifth, we evaluate the challenges to the chemical sciences to enable the cost-effective production of carbon-free power required. Finally, we discuss the effects of a change in primary power technology on the energy supply infrastructure and discuss the impact of such a change on the modes of energy consumption by the energy consumer and additional demands on the chemical sciences to support such a transition in energy supply.
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Bioinformatics as a Tool for Training in theScientific Method
Directory of Open Access Journals (Sweden)
J.F De Mesquita
2011-04-01
Full Text Available Within the Medical School of the Federal University of Rio de JaneiroState (UNIRIO, a course, named Scientific Initiation, allows students to develop a protocol using the scientific method under the supervision of an established researcher. Surprisingly, a group of ten medical students sought out thebioinformatics laboratory to carry-out their respective projects. Upon accepting the challenge of guiding the future physicians by the paths of the computational biology, the starting point was the article “Ataxin-2 intermediate-length polyglutamine expansions are associated withincreased risk for ALS”. Subsequent to initial meetings and a thorough literature review using the OMIM (Online Mendelian Inheritance in Man and PUBMED databases, the students defined their objective: defining a way to structurally analyze proteins carrying mutations detrimental to humansusing computational tools. The steps involvedincluded a search for natural variants of the protein in the ExPASy Proteomics Server, investigating the resolved native and variant protein structuresin the Protein Data Bank and, when these were not available, thecomparative or ab initiostructural modelling would be made. At the end of the semester, students were able to write a project in theformat required by funding agencies. Thisundertaking familiarized student with scientificareas not normally addressed in the medical curriculum and introduced hands-on learning of the scientific method.
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Expanding the role for psychology in addressing environmental challenges.
Clayton, Susan; Devine-Wright, Patrick; Swim, Janet; Bonnes, Mirilia; Steg, Linda; Whitmarsh, Lorraine; Carrico, Amanda
2016-04-01
Environmental challenges, though daunting, present an important area for psychologists to apply their knowledge. Psychological theories, research methods, and interventions are essential for examining the questions about human impacts, tendencies, and capacities that are integral to constructing effective responses to these challenges. Although a great deal of relevant research has been done, there is scope for psychologists to be more extensively involved. Following a brief review of existing research, we outline some important new directions. We also highlight 2 key divergences, arguing that psychological research needs to expand beyond a traditional, theory-based and decontextualized approach to environmental issues to incorporate a contextualized or "place-based" approach and a willingness to collaborate in interdisciplinary research teams that focus on specific environmental problems. Suggestions for promoting such interdisciplinary collaborations are reviewed. We encourage psychologists to expand their engagement with important environmental issues through multiple research approaches in order to further their understanding of human behavior, contributions to human well-being, and relevance to other disciplines and to society. (c) 2016 APA, all rights reserved).
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Final report on LDRD project : outstanding challenges for AlGaInN MOCVD.
Energy Technology Data Exchange (ETDEWEB)
Mitchell, Christine Charlotte; Follstaedt, David Martin; Russell, Michael J.; Cross, Karen Charlene; Wang, George T.; Creighton, James Randall; Allerman, Andrew Alan; Koleske, Daniel David; Lee, Stephen Roger; Coltrin, Michael Elliott
2005-03-01
The AlGaInN material system is used for virtually all advanced solid state lighting and short wavelength optoelectronic devices. Although metal-organic chemical vapor deposition (MOCVD) has proven to be the workhorse deposition technique, several outstanding scientific and technical challenges remain, which hinder progress and keep RD&A costs high. The three most significant MOCVD challenges are: (1) Accurate temperature measurement; (2) Reliable and reproducible p-doping (Mg); and (3) Low dislocation density GaN material. To address challenge (1) we designed and tested (on reactor mockup) a multiwafer, dual wavelength, emissivity-correcting pyrometer (ECP) for AlGaInN MOCVD. This system simultaneously measures the reflectance (at 405 and 550 nm) and emissivity-corrected temperature for each individual wafer, with the platen signal entirely rejected. To address challenge (2) we measured the MgCp{sub 2} + NH{sub 3} adduct condensation phase diagram from 65-115 C, at typical MOCVD concentrations. Results indicate that it requires temperatures of 80-100 C in order to prevent MgCp{sub 2} + NH{sub 3} adduct condensation. Modification and testing of our research reactor will not be complete until FY2005. A new commercial Veeco reactor was installed in early FY2004, and after qualification growth experiments were conducted to improve the GaN quality using a delayed recovery technique, which addresses challenge (3). Using a delayed recovery technique, the dislocation densities determined from x-ray diffraction were reduced from 2 x 10{sup 9} cm{sup -2} to 4 x 10{sup 8} cm{sup -2}. We have also developed a model to simulate reflectance waveforms for GaN growth on sapphire.
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Barthel, Roland; Ekström, Linda Louise; Ljungkvist, Andreas; Granberg, Maria; Merisalu, Johanna; Pokorny, Sebastian; Banzhaf, Stefan
2017-04-01
hydrology constitutes a boundary condition, other concerns, e.g., legal and economic, weigh high. Our research group was asked to provide an objective, neutral assessment of the islands' water availability under present and future scenario conditions. We performed a large measurement campaign over an entire hydrological year involving measurements of groundwater quality and quantity, water balance, and recharge calculations, as well as online surveys and interviews. The conditions on the archipelago are complex, and many scientific challenges are present. Our investigation is embedded in a larger project that looks at various dimensions of the problem. However, it appears that the question of groundwater availability and its spatial and temporal distribution is crucial. Water is abundant, but not always at the right place at the right time. Decentralized solutions are possible, but continuing with the current system is not. This provides a great challenge for our objectivity and neutrality, especially when communicating complex results of the investigation in appropriate and meaningful ways. Thus, the Koster Islands are not only a microcosm for Swedish coastal groundwater problems, but also for a wider range of issues combining scientific and societal challenges. 1. Lewis J, Sjöström J, Höök M, Sundström B. The Swedish model for groundwater policy: legal foundations, decision-making and practical application. Hydrogeol J. 2013;21(4):751-60.
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Ethical concepts and future challenges of neuroimaging: an Islamic perspective.
Al-Delaimy, Wael K
2012-09-01
Neuroscience is advancing at a rapid pace, with new technologies and approaches that are creating ethical challenges not easily addressed by current ethical frameworks and guidelines. One fascinating technology is neuroimaging, especially functional Magnetic Resonance Imaging (fMRI). Although still in its infancy, fMRI is breaking new ground in neuroscience, potentially offering increased understanding of brain function. Different populations and faith traditions will likely have different reactions to these new technologies and the ethical challenges they bring with them. Muslims are approximately one-fifth of world population and they have a specific and highly regulated ethical and moral code, which helps them deal with scientific advances and decision making processes in an Islamically ethical manner. From this ethical perspective, in light of the relevant tenets of Islam, neuroimaging poses various challenges. The privacy of spirituality and the thought process, the requirement to put community interest before individual interest, and emphasis on conscious confession in legal situations are Islamic concepts that can pose a challenge for the use of something intrusive such as an fMRI. Muslim moral concepts such as There shall be no harm inflicted or reciprocated in Islam and Necessities overrule prohibitions are some of the criteria that might appropriately be used to guide advancing neuroscience. Neuroscientists should be particularly prudent and well prepared in implementing neuroscience advances that are breaking new scientific and ethical ground. Neuroscientists should also be prepared to assist in setting the ethical frameworks in place in advance of what might be perceived as runaway applications of technology.
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Munro, Ian C; Haighton, Lois A; Lynch, Barry S; Tafazoli, Shahrzad
2009-12-01
The risk assessment of migration products resulting from packaging material has and continues to pose a difficult challenge. In most jurisdictions, there are regulatory requirements for the approval or notification of food contact substances that will be used in packaging. These processes generally require risk assessment to ensure safety concerns are addressed. The science of assessing food contact materials was instrumental in the development of the concept of Threshold of Regulation and the Threshold of Toxicological Concern procedures. While the risk assessment process is in place, the technology of food packaging continues to evolve to include new initiatives, such as the inclusion of antimicrobial substances or enzyme systems to prevent spoilage, use of plastic packaging intended to remain on foods as they are being cooked, to the introduction of more rigid, stable and reusable materials, and active packaging to extend the shelf-life of food. Each new technology brings with it the potential for exposure to new and possibly novel substances as a result of migration, interaction with other chemical packaging components, or, in the case of plastics now used in direct cooking of products, degradation products formed during heating. Furthermore, the presence of trace levels of certain chemicals from packaging that were once accepted as being of low risk based on traditional toxicology studies are being challenged on the basis of reports of adverse effects, particularly with respect to endocrine disruption, alleged to occur at very low doses. A recent example is the case of bisphenol A. The way forward to assess new packaging technologies and reports of very low dose effects in non-standard studies of food contact substances is likely to remain controversial. However, the risk assessment paradigm is sufficiently robust and flexible to be adapted to meet these challenges. The use of the Threshold of Regulation and the Threshold of Toxicological Concern concepts may
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Addressing HIV/AIDS challenges in Uganda: does social capital ...
African Journals Online (AJOL)
In addition, the success is attributed to the policy which allowed many actors to participate in the fight against the disease. The primary focus of this article is to map the process of social capital generation by NGOs and how social capital benefits enhance mitigation of HIV/AIDS challenges in Uganda. The key to social capital ...
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Gene Editing of Microalgae: Scientific Progress and Regulatory Challenges in Europe.
Spicer, Andrew; Molnar, Attila
2018-03-06
It is abundantly clear that the development of gene editing technologies, represents a potentially powerful force for good with regard to human and animal health and addressing the challenges we continue to face in a growing global population. This now includes the development of approaches to modify microalgal strains for potential improvements in productivity, robustness, harvestability, processability, nutritional composition, and application. The rapid emergence and ongoing developments in this area demand a timely review and revision of the current definitions and regulations around genetically modified organisms (GMOs), particularly within Europe. Current practices within the EU provide exemptions from the GMO directives for organisms, including crop plants and micro-organisms that are produced through chemical or UV/radiation mutagenesis. However, organisms generated through gene editing, including microalgae, where only genetic changes in native genes are made, remain currently under the GMO umbrella; they are, as such, excluded from practical and commercial opportunities in the EU. In this review, we will review the advances that are being made in the area of gene editing in microalgae and the impact of regulation on commercial advances in this area with consideration to the current regulatory framework as it relates to GMOs including GM microalgae in Europe.
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Full Text Available ... section Back to section menu It's Only Natural Planning ahead Breastfeeding and baby basics Making breastfeeding work ... It's Only Natural Overcoming challenges It's Only Natural Planning ahead Addressing breastfeeding myths Overcoming challenges Common questions ...
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Applying Scientific Principles to Resolve Student Misconceptions
Yin, Yue
2012-01-01
Misconceptions about sinking and floating phenomena are some of the most challenging to overcome (Yin 2005), possibly because explaining sinking and floating requires students to understand challenging topics such as density, force, and motion. Two scientific principles are typically used in U.S. science curricula to explain sinking and floating:…
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Data sharing policy design for consortia: challenges for sustainability.
Kaye, Jane; Hawkins, Naomi
2014-01-01
The field of human genomics has led advances in the sharing of data with a view to facilitating translation of research into innovations for human health. This change in scientific practice has been implemented through new policy developed by many principal investigators, project managers and funders, which has ultimately led to new forms of practice and innovative governance models for data sharing. Here, we examine the development of the governance of data sharing in genomics, and explore some of the key challenges associated with the design and implementation of these policies. We examine how the incremental nature of policy design, the perennial problem of consent, the gridlock caused by multiple and overlapping access systems, the administrative burden and the problems with incentives and acknowledgment all have an impact on the potential for data sharing to be maximized. We conclude by proposing ways in which the scientific community can address these problems, to improve the sustainability of data sharing into the future.
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Customizable scientific web portal for fusion research
International Nuclear Information System (INIS)
Abla, G.; Kim, E.N.; Schissel, D.P.; Flanagan, S.M.
2010-01-01
Web browsers have become a major application interface for participating in scientific experiments such as those in magnetic fusion. The recent advances in web technologies motivated the deployment of interactive web applications with rich features. In the scientific world, web applications have been deployed in portal environments. When used in a scientific research environment, such as fusion experiments, web portals can present diverse sources of information in a unified interface. However, the design and development of a scientific web portal has its own challenges. One such challenge is that a web portal needs to be fast and interactive despite the high volume of information and number of tools it presents. Another challenge is that the visual output of the web portal must not be overwhelming to the end users, despite the high volume of data generated by fusion experiments. Therefore, the applications and information should be customizable depending on the needs of end users. In order to meet these challenges, the design and implementation of a web portal needs to support high interactivity and user customization. A web portal has been designed to support the experimental activities of DIII-D researchers worldwide by providing multiple services, such as real-time experiment status monitoring, diagnostic data access and interactive data visualization. The web portal also supports interactive collaborations by providing a collaborative logbook, shared visualization and online instant messaging services. The portal's design utilizes the multi-tier software architecture and has been implemented utilizing web 2.0 technologies, such as AJAX, Django, and Memcached, to develop a highly interactive and customizable user interface. It offers a customizable interface with personalized page layouts and list of services, which allows users to create a unique, personalized working environment to fit their own needs and interests. This paper describes the software
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Customizable scientific web portal for fusion research
Energy Technology Data Exchange (ETDEWEB)
Abla, G., E-mail: abla@fusion.gat.co [General Atomics, P.O. Box 85608, San Diego, CA (United States); Kim, E.N.; Schissel, D.P.; Flanagan, S.M. [General Atomics, P.O. Box 85608, San Diego, CA (United States)
2010-07-15
Web browsers have become a major application interface for participating in scientific experiments such as those in magnetic fusion. The recent advances in web technologies motivated the deployment of interactive web applications with rich features. In the scientific world, web applications have been deployed in portal environments. When used in a scientific research environment, such as fusion experiments, web portals can present diverse sources of information in a unified interface. However, the design and development of a scientific web portal has its own challenges. One such challenge is that a web portal needs to be fast and interactive despite the high volume of information and number of tools it presents. Another challenge is that the visual output of the web portal must not be overwhelming to the end users, despite the high volume of data generated by fusion experiments. Therefore, the applications and information should be customizable depending on the needs of end users. In order to meet these challenges, the design and implementation of a web portal needs to support high interactivity and user customization. A web portal has been designed to support the experimental activities of DIII-D researchers worldwide by providing multiple services, such as real-time experiment status monitoring, diagnostic data access and interactive data visualization. The web portal also supports interactive collaborations by providing a collaborative logbook, shared visualization and online instant messaging services. The portal's design utilizes the multi-tier software architecture and has been implemented utilizing web 2.0 technologies, such as AJAX, Django, and Memcached, to develop a highly interactive and customizable user interface. It offers a customizable interface with personalized page layouts and list of services, which allows users to create a unique, personalized working environment to fit their own needs and interests. This paper describes the software
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The role of scientific institutions
International Nuclear Information System (INIS)
Gonzalez, A.J.
2002-01-01
The topic that was requested to address at this Nea seminar is the role (i.e., what is expected to be done) by institutions (i.e., organisations for the promotion of a public object) of a scientific nature (assisted by expert knowledge), with regard to a better integration of radiation protection in modern society. The scientific radiation protection institutions at an international level are the I.C.R.P. (non governmental), UNSCEAR (governmental) and the IAEA, acting together as an international forum. They are the focus of this paper. (N.C.)
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CSIR Research Space (South Africa)
Van Rensburg, JR
2010-08-31
Full Text Available years’ work of ongoing research in a Living Lab fashion to understand and address the two critical challenges of scalability and sustainability in the utilisation of technology (primarily Information and Communication Technologies – ICTs) as enablers...
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Concept Formation in Scientific Knowledge Discovery from a Constructivist View
Peng, Wei; Gero, John S.
The central goal of scientific knowledge discovery is to learn cause-effect relationships among natural phenomena presented as variables and the consequences their interactions. Scientific knowledge is normally expressed as scientific taxonomies and qualitative and quantitative laws [1]. This type of knowledge represents intrinsic regularities of the observed phenomena that can be used to explain and predict behaviors of the phenomena. It is a generalization that is abstracted and externalized from a set of contexts and applicable to a broader scope. Scientific knowledge is a type of third-person knowledge, i.e., knowledge that independent of a specific enquirer. Artificial intelligence approaches, particularly data mining algorithms that are used to identify meaningful patterns from large data sets, are approaches that aim to facilitate the knowledge discovery process [2]. A broad spectrum of algorithms has been developed in addressing classification, associative learning, and clustering problems. However, their linkages to people who use them have not been adequately explored. Issues in relation to supporting the interpretation of the patterns, the application of prior knowledge to the data mining process and addressing user interactions remain challenges for building knowledge discovery tools [3]. As a consequence, scientists rely on their experience to formulate problems, evaluate hypotheses, reason about untraceable factors and derive new problems. This type of knowledge which they have developed during their career is called "first-person" knowledge. The formation of scientific knowledge (third-person knowledge) is highly influenced by the enquirer's first-person knowledge construct, which is a result of his or her interactions with the environment. There have been attempts to craft automatic knowledge discovery tools but these systems are limited in their capabilities to handle the dynamics of personal experience. There are now trends in developing
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Available Tools and Challenges Classifying Cutting-Edge and Historical Astronomical Documents
Lagerstrom, Jill
2015-08-01
The STScI Library assists the Science Policies Division in evaluating and choosing scientific keywords and categories for proposals for the Hubble Space Telescope mission and the upcoming James Webb Space Telescope mission. In addition we are often faced with the question “what is the shape of the astronomical literature?” However, subject classification in astronomy in recent times has not been cultivated. This talk will address the available tools and challenges of classifying cutting-edge as well as historical astronomical documents. In at the process, we will give an overview of current and upcoming practices of subject classification in astronomy.
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A Canadian Effort to Address Fractions Teaching and Learning Challenges
Yearley, Shelley; Bruce, Catherine D.
2014-01-01
Teaching and learning fraction concepts provides challenges in primary schools all over the world. In this article, Shelley Yearley and Catherine Bruce describe a fractions-based research project conducted in Ontario, Canada.
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Addressing production stops in the food industry
DEFF Research Database (Denmark)
Hansen, Zaza Nadja Lee; Herbert, Luke Thomas; Jacobsen, Peter
2014-01-01
This paper investigates the challenges in the food industry which causes the production lines to stop, illustrated by a case study of an SME size company in the baked goods sector in Denmark. The paper proposes key elements this sector needs to be aware of to effectively address production stops......, and gives examples of the unique challenges faced by the SME food industry....
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Scientific Opinion on Risk Assessment of Synthetic Biology.
Epstein, Michelle M; Vermeire, Theo
2016-08-01
In 2013, three Scientific Committees of the European Commission (EC) drafted Scientific Opinions on synthetic biology that provide an operational definition and address risk assessment methodology, safety aspects, environmental risks, knowledge gaps, and research priorities. These Opinions contribute to the international discussions on the risk governance for synthetic biology developments. Copyright © 2016 Elsevier Ltd. All rights reserved.
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Addressing Cloud Computing in Enterprise Architecture: Issues and Challenges
Khan, Khaled; Gangavarapu, Narendra
2009-01-01
This article discusses how the characteristics of cloud computing affect the enterprise architecture in four domains: business, data, application and technology. The ownership and control of architectural components are shifted from organisational perimeters to cloud providers. It argues that although cloud computing promises numerous benefits to enterprises, the shifting control from enterprises to cloud providers on architectural components introduces several architectural challenges. The d...
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An Ethnomethodological Perspective on How Middle School Students Addressed a Water Quality Problem
Belland, Brian R.; Gu, Jiangyue; Kim, Nam Ju; Turner, David J.
2016-01-01
Science educators increasingly call for students to address authentic scientific problems in science class. One form of authentic science problem--socioscientific issue--requires that students engage in complex reasoning by considering both scientific and social implications of problems. Computer-based scaffolding can support this process by…
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[Scientific journals of medical students in Latin-America].
Cabrera-Samith, Ignacio; Oróstegui-Pinilla, Diana; Angulo-Bazán, Yolanda; Mayta-Tristán, Percy; Rodríguez-Morales, Alfonso J
2010-11-01
This article deals with the history and evolution of student's scientific journals in Latin-America, their beginnings, how many still exist and which is their future projection. Relevant events show the growth of student's scientific journals in Latin-America and how are they working together to improve their quality. This article is addressed not only for Latin American readers but also to worldwide readers. Latin American medical students are consistently working together to publish scientific research, whose quality is constantly improving.
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Building Bridges through Scientific Conferences
DEFF Research Database (Denmark)
Zierath, Juleen R
2016-01-01
Getting together to exchange ideas, forge collaborations, and disseminate knowledge is a long-standing tradition of scientific communities. How conferences are serving the community, what their current challenges are, and what is in store for the future of conferences are the topics covered...
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Agent 2003 Conference on Challenges in Social Simulation
Energy Technology Data Exchange (ETDEWEB)
Margaret Clemmons, ed.
2003-01-01
Welcome to the Proceedings of the fourth in a series of agent simulation conferences cosponsored by Argonne National Laboratory and The University of Chicago. Agent 2003 is the second conference in which three Special Interest Groups from the North American Association for Computational Social and Organizational Science (NAACSOS) have been involved in planning the program--Computational Social Theory; Simulation Applications; and Methods, Toolkits and Techniques. The theme of Agent 2003, Challenges in Social Simulation, is especially relevant, as there seems to be no shortage of such challenges. Agent simulation has been applied with increasing frequency to social domains for several decades, and its promise is clear and increasingly visible. Like any nascent scientific methodology, however, it faces a number of problems or issues that must be addressed in order to progress. These challenges include: (1) Validating models relative to the social settings they are designed to represent; (2) Developing agents and interactions simple enough to understand but sufficiently complex to do justice to the social processes of interest; (3) Bridging the gap between empirically spare artificial societies and naturally occurring social phenomena; (4) Building multi-level models that span processes across domains; (5) Promoting a dialog among theoretical, qualitative, and empirical social scientists and area experts, on the one hand, and mathematical and computational modelers and engineers, on the other; (6) Using that dialog to facilitate substantive progress in the social sciences; and (7) Fulfilling the aspirations of users in business, government, and other application areas, while recognizing and addressing the preceding challenges. Although this list hardly exhausts the challenges the field faces, it does identify topics addressed throughout the presentations of Agent 2003. Agent 2003 is part of a much larger process in which new methods and techniques are applied to
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Results of SSTC NRS Scientific and Technical Activities for 2014
International Nuclear Information System (INIS)
Nosovskij, A.V.; Valyigun, N.P.; Vorobej, I.I.; Kornijevska, O.S.
2015-01-01
The paper describes results of SSTC NRS scientific activities for 2014 in basic areas of activities. In particular, it addresses the development of nuclear regulatory control system, reviews, scientific and technical support to the SNRIU oversight function, research ampersand development and analytical efforts as well as scientific information and international activity. First-priority areas for SSTC NRS for the nearest years are identified
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Keynote address: the scientific basis of the present and future practice of clinical radiotherapy
International Nuclear Information System (INIS)
Fletcher, G.H.
1983-01-01
At mid-century radiotherapy was more an art than a science, but is presently based on radiobiological parameters and cell kinetics. This close interaction between basic scientific principles and clinical practice has been made possible because one can correlate quantitatively doses of irradiation with observed responses. First, a short historical review will be made because it gives a perspective for the understanding both of progress made and prevailing misconceptions. The important radiobiological parameters and cell kinetics will then be discussed in some detail to demonstrate that they should be thoroughly understood in their relationship to radiotherapy. The overall treatment planning must be based on the clinical applications of the main radiobiological parameters. The combined treatment with surgery, either pre- or postoperatively, and multiple daily fractionations will be used as examples. The teaching of radiobiology should be considerably expanded, not only for its own scientific merit but also to show how it applies to clinical situations. This should be reflected in the expansion of the board examination
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How desertification research is addressed in Argentina? Land versus Soil approaches
Torres, Laura; Abraham, Elena M.; Barbero, Celia; Marques, Maria J.; Ruiz, Manuel; Escadafal, Richard; Exbrayat, Williams
2013-04-01
Recommendations are not enough to solve problems of desertification. In certain areas, soil degradation and poverty establish a vicious circle that may be broken if political, social, economic and natural visions are considered as a whole. Nevertheless, usually the scientific framework to combat land degradation is only associated with the protection of natural resources - the "soil approach"-, and weak attention is paid on the social sciences - the "land approach". The success in the adoption of mitigation measures to combat dryland degradation depends on the dialogue between research institutes, policy makers, land users and funding agencies. The structure of desertification research and its implementation in Argentina is addressed in this study. It is one part of a wider framework of analysis that is simultaneously carried out in other different regions under the umbrella of a Task Force on Land and Soil promoted by DesertNet International. The ultimate goal of this Task Force is the achievement of an informed analysis to support the need of a scientific panel to answer the needs of the United Nations Convention to Combat Desertification. The features and orientation of such a panel to be truly effective may be established from the results of the analysis of the different ways to meet the challenge of combating desertification in different regions of the world and their success or failure. The method is based on the analysis of scientific journals indexed in the Web of Science using different searching criteria with different groups of keywords. The analysis of papers addresses three main criteria: the disciplines involved, the type of study and finally the range of the study in order to know the level of applicability. In order to compute and visualise clusters of elements bibliometric methods will be used. Positive signs have been recognised in Argentina in recent years trough the increase of governmental and non governmental organisation that are involved in
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Nuclear technologies to address the challenges in plant-water systems and adaptation strategies
International Nuclear Information System (INIS)
Datta, P.S.
2016-01-01
In India, over the last decade or so, the stagnation in yield and recent declining trend of the most popular varieties of wheat and rice suggest that the farmers' limited fields with the current soil fertility and agronomic practices has reached the limits of food production sustainability. While water is an important input resource in agriculture, a reliable assessment of its aggregate situation and its protection from depletion and degradation has not received its due respect in the management of agriculture. For enhancement in food production, besides the HYVs and agronomic practices, proper management of the limited groundwater resource, and the water demand under the scarce water availability conditions, enhancing water use efficiency and reducing post-harvest losses is important. Nuclear techniques can provide detailed insight into many long-term process governing Plant-Water Systems, and could be helpful to address the challenges in agriculture. Extensive studies on groundwater assessment and water use efficiency using radioactive "3H, "1"4C, "2"3"4U, "2"3"8U) and stable (2"H, "1"3C, "1"8O) isotopes, have been undertaken for over three decades in Punjab, Haryana, Delhi and Uttar Pradesh of the Gangetic Plains, in Sabarmati River Basin, Gujarat and in arid Rajasthan. Some examples have been discussed, along with HYV development and post harvest preservation using gamma irradiation
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Scientific Reporting: Raising the Standards
McLeroy, Kenneth R.; Garney, Whitney; Mayo-Wilson, Evan; Grant, Sean
2016-01-01
This article is based on a presentation that was made at the 2014 annual meeting of the editorial board of "Health Education & Behavior." The article addresses critical issues related to standards of scientific reporting in journals, including concerns about external and internal validity and reporting bias. It reviews current…
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Agile Scientists? : Investigating Agile Practices in Scientific Software Development
Sletholt, Magnus Thorstein
2011-01-01
The topic of this master thesis is development of scientific software. The research questions put forth are oriented towards specific agile practices and whether these are present in the development processes of scientific software projects. Moreover, the effects of applying such agile practices, particularly pertaining to the handling of requirements and testing, in scientific software projects are addressed in the thesis. In order to answer the proposed research questions a table consisting...
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VISIR: Experiences and Challenges
Directory of Open Access Journals (Sweden)
Mohamed Tawfik
2012-02-01
Full Text Available It is of crucial importance the integration of practical sessions in engineering curricula owing to their significant role in understanding engineering concepts and scientific phenomena. However, the lack of practical sessions due to the high costs of the equipment and the unavailability of instructors has caused a significant declination in experimentation in engineering education. Remote laboratories have tackled this issues providing online reusable and shared workbenches unconstrained by neither geographical nor time considerations. Thereby, they have extremely proliferated among universities and integrated into engineering curricula over the last decade. This contribution compiles diverse experiences based on the deployment of the remote laboratory, Virtual Instrument Systems in Reality (VISIR, on the practices of undergraduate engineering grades at various universities within the VISIR community. It aims to show the impact of its usage on engineering education concerning the assessments of students and teachers as well. In addition, the paper address the next challenges and future works carried out at several universities within the VISIR community.
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Pre-service teachers and socio-scientific inquiry : Opportunities and challenges
Knippels, M.C.P.J.; van Harskamp, M.; Verhoeff, R.P.; Postma, P.A.
2017-01-01
This paper presents the results of a teacher training program aiming to enable pre-service teachers to engage secondary education students in Socio-Scientific Inquiry-Based Learning (SSIBL). In SSIBL – an approach developed within the European project PARRISE – students formulate questions about
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Teaching Digital Natives: Promoting Information Literacy and Addressing Instructional Challenges
Neumann, Crystal
2016-01-01
Technology must be used as a teaching and learning tool to help students succeed. However, educators must be proactive in identifying some of the pitfalls of technology, such as information illiteracy. The phenomenological study covers how English instructors from Indianapolis, who teach first year students, address information literacy and the…
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Scientific publishing: some food for thought (Italian original version
Directory of Open Access Journals (Sweden)
Vittorio Bo
2007-03-01
Full Text Available Scientific publishing, here to be considered in a broader sense, as publishing of both specialised scientific journals and science popularisation works addressed to a wider audience, has been sailing for some years on troubled waters. To gather some possible food for thought is the purpose of this brief article.
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Scientific review of psychophysiological detection of deceit
Directory of Open Access Journals (Sweden)
Igor Areh
2016-10-01
Full Text Available Psychophysiological detection of deceit has been in the centre of attention in the recent decade, which correlates with heightened security challenges of a modern world. The article provides scientific discussion about polygraph that is used in criminal investigation. Two most employed polygraph techniques are critically presented, examined and compared: the Comparison Question Test (CQT and the Concealed Information Test (CIT. Theoretical foundations, objectivity and standardization of testing procedures, ethical and practical issues are analysed. Proponents of the Comparison Question Test have not been successful in their efforts to resolve fundamental problems and limitations with which the technique is challenged. It remains unstandardized and unscientific, separated from science and mainly without attempts to escape from the dead-end. The most influential theoretical backgrounds of CQT technique are examined; however, none of them represents a satisfactory scientific foundation of the technique. Without being scientifically grounded in a verifiable theory, it remains controversial and caught into self-sufficiency, mostly supported by methodologically questionable research findings gained by proponents. To the contrary, the Concealed Information Test is associated with fast development, particularly in the field of neurology, and is considered to be less disputed and to be partly supported by a sound scientific ground. Applying the Concealed Question Test, somewhat naïve and disputable detection of lies typical of the Comparison Question Test is replaced by a search for information that lies concealed in the suspects’ memory. However, the Concealed Information Test also has been challenged by serious deficiencies, which bring forward a question about justification of the use of the polygraph.
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Symposium 1: Challenges in science education and popularization of Science
Directory of Open Access Journals (Sweden)
Ildeo de Castro Moreira
2014-08-01
Full Text Available Science education and popularization of science are important elements for social inclusion. The Brazil exhibits strong inequalities regarding the distribution of wealth, access to cultural assets and appropriation of scientific and technological knowledge. Each Brazilian should have the opportunity to acquire a basic knowledge of science and its operation that allow them to understand their environment and expand their professional opportunities. However, the overall performance of Brazilian students in science and math is bad. The basic science education has, most often, few resources and is discouraging, with little appreciation of experimentation, interdisciplinarity and creativity. Beside the shortage of science teachers, especially teachers with good formation, predominate poor wage and working conditions, and deficiencies in instructional materials and laboratories. If there was a significant expansion in access to basic education, the challenge remains to improve their quality. According to the last National Conference of STI, there is need of a profound educational reform at all levels, in particular with regard to science education. Already, the popularization of science can be an important tool for the construction of scientific culture and refinement of the formal teaching instrument. However, we still lack a comprehensive and adequate public policy to her intended. Clearly, in recent decades, an increase in scientific publication occurred: creating science centers and museums; greater media presence; use of the internet and social networks; outreach events, such as the National Week of CT. But the scenario is shown still fragile and limited to broad swathes of Brazilians without access to scientific education and qualified information on CT. In this presentation, from a general diagnosis of the situation, some of the main challenges related to education and popularization of science in the country will address herself.
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Exploring corporate eco-modernism: Challenging corporate rhetoric and scientific discourses
DEFF Research Database (Denmark)
Ulhøi, John Parm; Welford, Richard
2000-01-01
in shaping a new corporate environmentalism and, ten years on, we argue that it is time to step back and critically assess the nature and scope of corporate actions and scientific research within the field of corporate environmental management. This paper starts from the assertions that: (i) disturbing...
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Low, Martyn E Y; Evenhuis, Neal L
2013-01-01
The dates of publication and exact titles of the 83 parts of the Zoology of the Report of the Scientific Results of the Voyage of H.M.S. Challenger During the Years 1873-76 are presented. Exact dates of publication for 71 of these parts have been determined using notices of their publication in contemporary publications. The dates of publication of the two Narrative volumes of the voyage of the H.M.S. Challenger (which contain available indications of new names) are also determined.
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Roncarolo, Federico; Boivin, Antoine; Denis, Jean-Louis; Hébert, Rejean; Lehoux, Pascale
2017-09-08
While there is an extensive literature on Health System (HS) strengthening and on the performance of specific HSs, there are few exhaustive syntheses of the challenges HSs are facing worldwide. This paper reports the findings of a scoping review aiming to classify the challenges of HSs investigated in the scientific literature. Specifically, it determines the kind of research conducted on HS challenges, where it was performed, in which health sectors and on which populations. It also identifies the types of challenge described the most and how they varied across countries. We searched 8 databases to identify scientific papers published in English, French and Italian between January 2000 and April 2016 that addressed HS needs and challenges. The challenges reported in the articles were classified using van Olmen et al.'s dynamic HS framework. Countries were classified using the Human Development Index (HDI). Our analyses relied on descriptive statistics and qualitative content analysis. 292 articles were included in our scoping review. 33.6% of these articles were empirical studies and 60.1% were specific to countries falling within the very high HDI category, in particular the United States. The most frequently researched sectors were mental health (41%), infectious diseases (12%) and primary care (11%). The most frequently studied target populations included elderly people (23%), people living in remote or poor areas (21%), visible or ethnic minorities (15%), and children and adolescents (15%). The most frequently reported challenges related to human resources (22%), leadership and governance (21%) and health service delivery (24%). While health service delivery challenges were more often examined in countries within the very high HDI category, human resources challenges attracted more attention within the low HDI category. This scoping review provides a quantitative description of the available evidence on HS challenges and a qualitative exploration of the
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Analogy and Intersubjectivity: Political Oratory, Scholarly Argument and Scientific Reports.
Gross, Alan G.
1983-01-01
Focuses on the different ways political oratory, scholarly argument, and scientific reports use analogy. Specifically, analyzes intersubjective agreement in Franklin D. Roosevelt's First Inaugural address, the scholarly argument between Sir Karl Popper and Thomas S. Kuhn, and the scientific reports of various mathematicians and scientists. (PD)
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Onward, Christian penguins: wildlife film and the image of scientific authority.
Wexler, Rebecca
2008-09-01
Within US media reactions to March of the penguins, animal images became an arena for displaced conflicts of human interest. This paper examines an intermediary step through which the film became a medium for social disagreement: conflict over control of the cultural authority to interpret animal images. I analyze claims to the cultural honorific of science made within disputes over readings of the film as evidence for intelligent design (ID). I argue that published refutations of this reading were largely misguided in that they tended to group arguments-for-ID with a suite of social-allegorical readings of the film. By failing to address essential differences between interpretations, critics of the arguments-for-ID necessarily overlooked their problematic and unexamined claim that the film shares the cultural authority of science. Furthermore, where critics of the ID readings might have challenged this claim, they often replicated it instead. This overarching failure critically to assess the status of the film's scientific authority may have resulted from audience expectations about the genre of wildlife films, the advertising strategy of the film's US distributors, and structural ambiguities within the film concerning its status as a scientific representation.
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Expanding the use of Scientific Data through Maps and Apps
Shrestha, S. R.; Zimble, D. A.; Herring, D.; Halpert, M.
2014-12-01
The importance of making scientific data more available can't be overstated. There is a wealth of useful scientific data available and demand for this data is only increasing; however, applying scientific data towards practical uses poses several technical challenges. These challenges can arise from difficulty in handling the data due largely to 1) the complexity, variety and volume of scientific data and 2) applying and operating the techniques and tools needed to visualize and analyze the data. As a result, the combined knowledge required to take advantage of these data requires highly specialized skill sets that in total, limit the ability of scientific data from being used in more practical day-to-day decision making activities. While these challenges are daunting, information technologies do exist that can help mitigate some of these issues. Many organizations for years have already been enjoying the benefits of modern service oriented architectures (SOAs) for everyday enterprise tasks. We can use this approach to modernize how we share and access our scientific data where much of the specialized tools and techniques needed to handle and present scientific data can be automated and executed by servers and done so in an appropriate way. We will discuss and show an approach for preparing file based scientific data (e.g. GRIB, netCDF) for use in standard based scientific web services. These scientific web services are able to encapsulate the logic needed to handle and describe scientific data through a variety of service types including, image, map, feature, geoprocessing, and their respective service methods. By combining these types of services and leveraging well-documented and modern web development APIs, we can afford to focus our attention on the design and development of user-friendly maps and apps. Our scenario will include developing online maps through these services by integrating various forecast data from the Climate Forecast System (CFSv2). This
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The RA nuclear research reactor at VINCA Institute as an engineering and scientific challenge
International Nuclear Information System (INIS)
Mesarovic, M.
1997-01-01
The RA nuclear research at the Vinca Institute of Nuclear Sciences is the largest nuclear research facility in Yugoslavia and belongs to that generation of research reactors which have had an important contribution to nuclear technology development. As these older reactors were generally not built to specific nuclear standards, new safety systems had to be installed at the RA reactor for a renewal of its operating licence in 1984 and it was shut down, after 25 years of operation. Although all the required and several additional systems were built for the restart of the RA reactor, a disruption of foreign delivery of new control equipment caused its conversion to a 'dormant' facility, and it is still out of operation. Therefore, the future status of the RA reactor presents an engineering and scientific challenge to the engineers and scientists from Yugoslavia and other countries that may be interested to participate. To attract their attention on the subject, principal features of the RA reactor and its present status are described in detail, based on a recent engineering economic and safety evaluation. A comparative review of the world research reactors is also presented.(author)
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Faivre, Nicolas; Fritz, Marco; Freitas, Tiago; de Boissezon, Birgit; Vandewoestijne, Sofie
2017-11-01
Contemporary societies are facing a broad range of challenges, from pressures on human health and well-being to natural capital depletion, and the security of food, water and energy. These challenges are deeply intertwined with global processes, such as climate change and with local events such as natural disasters. The EU's research & innovation (R&I) policy is now seeking to address these challenges from a new perspective, with Nature-Based Solutions, and turn them into innovation opportunities that optimise the synergies between nature, society and the economy. Nature-Based Solutions can be an opportunity for innovation, and are here promoted by both policymakers and practitioners as a cost-effective way of creating a greener, more sustainable, and more competitive economy. Since 2013, the European Commission has devoted particular attention to Nature-Based Solutions through consultations and dialogues that sought to make the concept of these solutions more concrete and to define the concept's place within the spectrum of ecosystem-based approaches. In 2014, the Commission launched an expert group, which conducted further analysis, and made recommendations to help increase the use of Nature-Based Solutions and bring nature back into cities. In 2015, a survey was conducted on citizens' views and perceptions of 'Nature in Cities' to provide further insight for future work. Based on these elements and on results from running EU projects, the Commission has developed an R&I agenda for Nature-Based Solutions and has published targeted calls for proposals for large-scale demonstration projects in this field in 2016 and 2017. Additional R&I actions at EU level that promote systemic Nature-Based Solutions and their benefits to cities and territories are planned with the aim to improve the implementation capacity and evidence base for deploying Nature-Based Solutions and developing corresponding future markets. They are also expected to foster an interdisciplinary R
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Reading handprinted addresses on IRS tax forms
Ramanaprasad, Vemulapati; Shin, Yong-Chul; Srihari, Sargur N.
1996-03-01
The hand-printed address recognition system described in this paper is a part of the Name and Address Block Reader (NABR) system developed by the Center of Excellence for Document Analysis and Recognition (CEDAR). NABR is currently being used by the IRS to read address blocks (hand-print as well as machine-print) on fifteen different tax forms. Although machine- print address reading was relatively straightforward, hand-print address recognition has posed some special challenges due to demands on processing speed (with an expected throughput of 8450 forms/hour) and recognition accuracy. We discuss various subsystems involved in hand- printed address recognition, including word segmentation, word recognition, digit segmentation, and digit recognition. We also describe control strategies used to make effective use of these subsystems to maximize recognition accuracy. We present system performance on 931 address blocks in recognizing various fields, such as city, state, ZIP Code, street number and name, and personal names.
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A "Semantic" View of Scientific Models for Science Education
Adúriz-Bravo, Agustín
2013-01-01
In this paper I inspect a "semantic" view of scientific models taken from contemporary philosophy of science-I draw upon the so-called "semanticist family", which frontally challenges the received, syntactic conception of scientific theories. I argue that a semantic view may be of use both for science education in the…
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SCIENTIFIC STUDY OF NATURE AND SCIENTIFIC STUDY OF CULTURE: INTE-GRATION TREND, PRACTICAL VALUE
Directory of Open Access Journals (Sweden)
Fokina Zoya Titovna
2017-03-01
Full Text Available This article deals with a topic of interest : studying the expanding and deepening trend of integration of natural, technical, social and humanities fields of scientific knowledge. The point of absolute opposition between the sciences dealing with nature and those dealing with culture is subjected to criticism, the forms of integration of scientific knowledge are identified: mathematization, formalization, computerization of knowledge; philosophization/dialectization and environmentalization of the scientific knowledge. It is noted that such areas of scientific knowledge as synergetics, cybernetics, system theory, information technology, sociosynergetics, historical informatics, cliometrics, informatics for economics, evolutionary economics, human ecology, etc. Many scientific fields appear on the border between the science, technology and mathematics, and social and humanities studies, while the sharp borders between the natural sciences and cultural sciences tend to disappear, although specifics of studying the social reality still exists. Within the context of integration of sciences, comprehensive approach, synergetics, cybernetics, and mathematical model approach are analyzed. The philosophy of technology, and environmental problems, which are caused by the development of technological civilization, are studied. Practical value of integration processes in science is identified. The studied data is addressed to the specialists who are interested in the modern processes of integration of sciences, and modern issues of scientific and technical development of humanity, survival of humanity under the conditions of increasing technological understanding of the nature.
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Adoptive T cell therapy: Addressing challenges in cancer immunotherapy
Directory of Open Access Journals (Sweden)
Yee Cassian
2005-04-01
Full Text Available Abstract Adoptive T cell therapy involves the ex vivo selection and expansion of effector cells for the treatment of patients with cancer. In this review, the advantages and limitations of using antigen-specific T cells are discussed in counterpoint to vaccine strategies. Although vaccination strategies represent more readily available reagents, adoptive T cell therapy provides highly selected T cells of defined phenotype, specificity and function that may influence their biological behavior in vivo. Adoptive T cell therapy offers not only translational opportunities but also a means to address fundamental issues in the evolving field of cancer immunotherapy.
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Scientific publications in Nepal.
Magar, A
2012-09-01
Scientific publications have become a mainstay of communication among readers, academicians, researchers and scientists worldwide. Although, its existence dates back to 17 th century in the West, Nepal is still struggling to take few steps towards improving its local science for last 50 years. Since the start of the first medical journal in 1963, the challenges remains as it were decades back regarding role of authors, peer reviewers, editors and even publishers in Nepal. Although, there has been some development in terms of the number of articles being published and appearances of the journals, yet there is a long way to go. This article analyzes the past and present scenario, and future perspective for scientific publications in Nepal.
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Mythical thinking, scientific discourses and research dissemination.
Hroar Klempe, Sven
2011-06-01
This article focuses on some principles for understanding. By taking Anna Mikulak's article "Mismatches between 'scientific' and 'non-scientific' ways of knowing and their contributions to public understanding of science" (IPBS 2011) as a point of departure, the idea of demarcation criteria for scientific and non-scientific discourses is addressed. Yet this is juxtaposed with mythical thinking, which is supposed to be the most salient trait of non-scientific discourses. The author demonstrates how the most widespread demarcation criterion, the criterion of verification, is self-contradictory, not only when it comes to logic, but also in the achievement of isolating natural sciences from other forms of knowledge. According to Aristotle induction is a rhetorical device and as far as scientific statements are based on inductive inferences, they are relying on humanities, which rhetoric is a part of. Yet induction also has an empirical component by being based on sense-impressions, which is not a part of the rhetoric, but the psychology. Also the myths are understood in a rhetorical (Lévi-Strauss) and a psychological (Cassirer) perspective. Thus it is argued that both scientific and non-scientific discourses can be mythical.
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Analyzing Data Citations to Assess the Scientific and Societal Value of Scientific Data
Chen, R. S.; Downs, R. R.
2012-12-01
the data extensively to identify the potential impact of the data on the scientific fields represented by those journals. Furthermore, an initial analysis was conducted of citations that appeared in non-peer-reviewed publications and the popular media to assess the potential policy and educational impacts of these data. The initial results of these analyses demonstrate the significant challenges that remain for assessing the value of scientific data to both science and society.
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Addressing Global Environmental Challenges through Interdisciplinary Biogeochemical Research
Paytan, A.
2013-12-01
Our planet is dynamic; energy and matter constantly move between the hydrosphere, atmosphere and lithosphere on time scales from seconds to millenia. These tight interactions - including those between organisms and their physical environment - are what make Earth habitable. However, as Rachel Carson wrote, 'Only within the moment of time represented by the present century has one species - man - acquired significant power to alter the nature of this world'. Globalization and explosive population growth have generated far-reaching environmental problems on a scale that humanity has never faced before. Fortunately, our species has also developed an unprecedented ability to provide science-based solutions. Since processes impacting the environment involve complex biological, physical, chemical and geological interactions and feedbacks, they require the integration of expertise from all these scientific disciplines as well as input from policy makers, social scientists, and economists. This talk presents four examples of current interdisciplinary research projects conducted in my lab, each one related to a theme from one of Carson's books (Under the Sea-wind, The Sea Around Us, The Edge of the Sea, and Silent Spring). These projects, and others like them, provide hope that we can move toward a sustainable relationship with the natural world by encouraging the best scientists to conduct interdisciplinary research with direct applications for environmental management and stewardship.
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Catalyzing Open and Collaborative Science to Address Global ...
International Development Research Centre (IDRC) Digital Library (Canada)
As the cost of computer hardware continues to drop and developing-country researchers get increased access to the Internet and mobile phones, each offers the potential for solving these development challenges by opening up the scientific process. What is open science? At the heart of the open science concept is the ...
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Professional cluster management by a small scientific team: challenges, solutions and perspectives
International Nuclear Information System (INIS)
Silva, Vitor V.A.; Santos, Andre A.C. dos; Cunha, Renan O.
2017-01-01
The specification, configuration and management of a professional computer cluster are specialized tasks usually hold by well trained teams, often full-time hired computer scientists. However, in many situations and for widely different reasons, these very specific technical tasks must be carried on by no other than the user itself. This is the situation at Centro de Desenvolvimento da Tecnologia Nuclear - and in many nuclear research and educational centres in developing countries - where the scientists are the users of the cluster but also the technical team responsible to keep the system running. This paper presents the process of planning and installing the whole operating system and scientific software of a professional cluster aimed to be used in the nuclear engineering eld from the point of view of its users. The drawbacks of lack of expertise and technical skills to manage such type of technology are opposed to the advantages of freedom to chose the solutions which best t to the problems to be solved. The details of selected methods or technologies chosen for addressing a specific matter are presented together with other possible options, offering a broader view of the whole process of cluster's configuration. Specificities of dealing with closed, restricted and open software, common in the nuclear engineering eld, are also put in perspective. The ideas and solutions presented in this paper can be a valuable reference to other research teams found in a similar situation: being scientists and its own technical staff at the same time. (author)
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Professional cluster management by a small scientific team: challenges, solutions and perspectives
Energy Technology Data Exchange (ETDEWEB)
Silva, Vitor V.A.; Santos, Andre A.C. dos; Cunha, Renan O., E-mail: vitors@cdtn.br, E-mail: aacs@cdtn.br, E-mail: roc@cdtn.br [Centro de Desenvolvimento da Tecnologia Nuclear (CDTN/CNEN-MG), Belo Horizonte, MG (Brazil)
2017-11-01
The specification, configuration and management of a professional computer cluster are specialized tasks usually hold by well trained teams, often full-time hired computer scientists. However, in many situations and for widely different reasons, these very specific technical tasks must be carried on by no other than the user itself. This is the situation at Centro de Desenvolvimento da Tecnologia Nuclear - and in many nuclear research and educational centres in developing countries - where the scientists are the users of the cluster but also the technical team responsible to keep the system running. This paper presents the process of planning and installing the whole operating system and scientific software of a professional cluster aimed to be used in the nuclear engineering eld from the point of view of its users. The drawbacks of lack of expertise and technical skills to manage such type of technology are opposed to the advantages of freedom to chose the solutions which best t to the problems to be solved. The details of selected methods or technologies chosen for addressing a specific matter are presented together with other possible options, offering a broader view of the whole process of cluster's configuration. Specificities of dealing with closed, restricted and open software, common in the nuclear engineering eld, are also put in perspective. The ideas and solutions presented in this paper can be a valuable reference to other research teams found in a similar situation: being scientists and its own technical staff at the same time. (author)
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HNSciCloud - Overview and technical Challenges
Gasthuber, Martin; Meinhard, Helge; Jones, Robert
2017-10-01
HEP is only one of many sciences with sharply increasing compute requirements that cannot be met by profiting from Moore’s law alone. Commercial clouds potentially allow for realising larger economies of scale. While some small-scale experience requiring dedicated effort has been collected, public cloud resources have not been integrated yet with the standard workflows of science organisations in their private data centres; in addition, European science has not ramped up to significant scale yet. The HELIX NEBULA Science Cloud project - HNSciCloud, partly funded by the European Commission, addresses these points. Ten organisations under CERN’s leadership, covering particle physics, bioinformatics, photon science and other sciences, have joined to procure public cloud resources as well as dedicated development efforts towards this integration. The HNSciCloud project faces the challenge to accelerate developments performed by the selected commercial providers. In order to guarantee cost efficient usage of IaaS resources across a wide range of scientific communities, the technical requirements had to be carefully constructed. With respect to current IaaS offerings, dataintensive science is the biggest challenge; other points that need to be addressed concern identity federations, network connectivity and how to match business practices of large IaaS providers with those of public research organisations. In the first section, this paper will give an overview of the project and explain the findings so far. The last section will explain the key points of the technical requirements and present first results of the experience of the procurers with the services in comparison to their’on-premise’ infrastructure.
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Krska, Shane W; DiRocco, Daniel A; Dreher, Spencer D; Shevlin, Michael
2017-12-19
The structural complexity of pharmaceuticals presents a significant challenge to modern catalysis. Many published methods that work well on simple substrates often fail when attempts are made to apply them to complex drug intermediates. The use of high-throughput experimentation (HTE) techniques offers a means to overcome this fundamental challenge by facilitating the rational exploration of large arrays of catalysts and reaction conditions in a time- and material-efficient manner. Initial forays into the use of HTE in our laboratories for solving chemistry problems centered around screening of chiral precious-metal catalysts for homogeneous asymmetric hydrogenation. The success of these early efforts in developing efficient catalytic steps for late-stage development programs motivated the desire to increase the scope of this approach to encompass other high-value catalytic chemistries. Doing so, however, required significant advances in reactor and workflow design and automation to enable the effective assembly and agitation of arrays of heterogeneous reaction mixtures and retention of volatile solvents under a wide range of temperatures. Associated innovations in high-throughput analytical chemistry techniques greatly increased the efficiency and reliability of these methods. These evolved HTE techniques have been utilized extensively to develop highly innovative catalysis solutions to the most challenging problems in large-scale pharmaceutical synthesis. Starting with Pd- and Cu-catalyzed cross-coupling chemistry, subsequent efforts expanded to other valuable modern synthetic transformations such as chiral phase-transfer catalysis, photoredox catalysis, and C-H functionalization. As our experience and confidence in HTE techniques matured, we envisioned their application beyond problems in process chemistry to address the needs of medicinal chemists. Here the problem of reaction generality is felt most acutely, and HTE approaches should prove broadly enabling
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Preventing and Addressing Challenging Behavior: Common Questions and Practical Strategies
Hemmeter, Mary Louise; Ostrosky, Michaelene M.; Corso, Robert M.
2012-01-01
The purpose of this article is to offer preschool teachers strategies for preventing challenging behavior and supporting the development of social skills and emotional competencies. This article is framed in a question and answer format using questions from teachers who the authors have worked with in the past. These questions and strategies are…
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Scientific Assistant Virtual Laboratory (SAVL)
Alaghband, Gita; Fardi, Hamid; Gnabasik, David
2007-03-01
The Scientific Assistant Virtual Laboratory (SAVL) is a scientific discovery environment, an interactive simulated virtual laboratory, for learning physics and mathematics. The purpose of this computer-assisted intervention is to improve middle and high school student interest, insight and scores in physics and mathematics. SAVL develops scientific and mathematical imagination in a visual, symbolic, and experimental simulation environment. It directly addresses the issues of scientific and technological competency by providing critical thinking training through integrated modules. This on-going research provides a virtual laboratory environment in which the student directs the building of the experiment rather than observing a packaged simulation. SAVL: * Engages the persistent interest of young minds in physics and math by visually linking simulation objects and events with mathematical relations. * Teaches integrated concepts by the hands-on exploration and focused visualization of classic physics experiments within software. * Systematically and uniformly assesses and scores students by their ability to answer their own questions within the context of a Master Question Network. We will demonstrate how the Master Question Network uses polymorphic interfaces and C# lambda expressions to manage simulation objects.
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Saleh, R.
2017-12-01
For a challenge as complex and far-reaching as sea level rise and improving shoreline resiliency, strong partnerships between scientists, elected officials, decision-makers, and the general public are the only way that effective solutions can be developed. The San Francisco Bay, like many similar sheltered water coastal environments (for example, Galveston Bay, Tampa Bay, or Venetian Lagoon) offers a unique opportunity for multiple jurisdictions to collaborate to address sea level rise on a regional basis. For the San Francisco Bay, significant scientific progress has been made in building a real-time simulation model for riverine and Bay hydrodynamics. Other major scientific initiatives, such as morphology mapping, shoreline mapping, and a sediment budget are also underway. In 2014, leaders from the Bay Area science, engineering, planning, policy, elected, and regulatory communities representing jurisdictions around the Bay joined together to address sea level rise. The group includes people from local, regional, state, and federal agencies and organizations. Together, CHARG (Coastal Hazards Adaptation Resiliency Group) established a collective vision and approach to implementing regional solutions. Decision-makers within many Bay Area jurisdictions are motivated to show demonstrable progress toward addressing sea level rise. However, the cost to implement shoreline resiliency solutions will be very large, and must be founded on strong science.CHARG is now tackling several key technical challenges. One is to develop science-based guidelines for local jurisdictions to determine when a project is local, sub-regional, or regional. Concurrently, several organizations are planning or implementing pilot shoreline resiliency projects and other programs. Many creative regional solutions are possible in a sheltered water environment that simply would not be feasible along the open coast. By definition, these solutions cannot be undertaken by one entity alone. Large
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Abdulhamid, Shafi'i Muhammad; Abd Latiff, Muhammad Shafie; Abdul-Salaam, Gaddafi; Hussain Madni, Syed Hamid
2016-01-01
Cloud computing system is a huge cluster of interconnected servers residing in a datacenter and dynamically provisioned to clients on-demand via a front-end interface. Scientific applications scheduling in the cloud computing environment is identified as NP-hard problem due to the dynamic nature of heterogeneous resources. Recently, a number of metaheuristics optimization schemes have been applied to address the challenges of applications scheduling in the cloud system, without much emphasis on the issue of secure global scheduling. In this paper, scientific applications scheduling techniques using the Global League Championship Algorithm (GBLCA) optimization technique is first presented for global task scheduling in the cloud environment. The experiment is carried out using CloudSim simulator. The experimental results show that, the proposed GBLCA technique produced remarkable performance improvement rate on the makespan that ranges between 14.44% to 46.41%. It also shows significant reduction in the time taken to securely schedule applications as parametrically measured in terms of the response time. In view of the experimental results, the proposed technique provides better-quality scheduling solution that is suitable for scientific applications task execution in the Cloud Computing environment than the MinMin, MaxMin, Genetic Algorithm (GA) and Ant Colony Optimization (ACO) scheduling techniques.
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Abdulhamid, Shafi’i Muhammad; Abd Latiff, Muhammad Shafie; Abdul-Salaam, Gaddafi; Hussain Madni, Syed Hamid
2016-01-01
Cloud computing system is a huge cluster of interconnected servers residing in a datacenter and dynamically provisioned to clients on-demand via a front-end interface. Scientific applications scheduling in the cloud computing environment is identified as NP-hard problem due to the dynamic nature of heterogeneous resources. Recently, a number of metaheuristics optimization schemes have been applied to address the challenges of applications scheduling in the cloud system, without much emphasis on the issue of secure global scheduling. In this paper, scientific applications scheduling techniques using the Global League Championship Algorithm (GBLCA) optimization technique is first presented for global task scheduling in the cloud environment. The experiment is carried out using CloudSim simulator. The experimental results show that, the proposed GBLCA technique produced remarkable performance improvement rate on the makespan that ranges between 14.44% to 46.41%. It also shows significant reduction in the time taken to securely schedule applications as parametrically measured in terms of the response time. In view of the experimental results, the proposed technique provides better-quality scheduling solution that is suitable for scientific applications task execution in the Cloud Computing environment than the MinMin, MaxMin, Genetic Algorithm (GA) and Ant Colony Optimization (ACO) scheduling techniques. PMID:27384239
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Scientific realism in particle physics a causal approach
Egg, Matthias
2014-01-01
Does particle physics really describe the basic constituents of the material world or is it just a useful tool for deriving empirical predictions? This book proposes a novel answer to that question, emphasizing the importance of causal reasoning for the justification of scientific claims. It thereby responds to general worries about scientific realism as well as to more specific challenges stemming from the interpretation of quantum physics.
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Scientific and non-scientific information in the uptake of health information: The case of Ebola
Directory of Open Access Journals (Sweden)
Bankole A. Falade
2017-07-01
Full Text Available The Ebola virus disease outbreak in West Africa (2013–2016 claimed over 10 000 lives in less than 18 months. Low levels of familiarity with the disease, ease of transmission, scale of infection, gruesomeness of symptoms, lack of cure and high fatality rate created a global panic. From the perspective of the social psychology of communication and content analysis, this study examines media coverage of the crisis in Africa with a view to unpacking the scientific and non-scientific information that may have framed public understanding of the disease. Findings show that accepting scientific advice was not unproblematic, because of the similarity of early symptoms with known diseases such as Lassa, dengue and malaria fevers. Cultural and religious actors and beliefs posed a paradox for believers as the public assimilated disease prevention information into existing norms and practices. Rumours and conspiracy theories about Western governments and pharmaceuticals also contributed to the rejection of the scientific explanation of its origin. Fear of the devastating effects of the disease and the lack of a cure led to the stigmatisation of the infected and treatment centres and ultimately to public revolts. Findings show the importance of non-scientific information and actors in matters of health and illness in Africa. Significance: Scientific knowledge is not enough to change health behaviour. Non-scientific knowledge and actors, traditional and religious practices, rumours and conspiracy theories must all be factored into efforts to address behavioural change.
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Making Scientific Data Usable and Useful
Satwicz, T.; Bharadwaj, A.; Evans, J.; Dirks, J.; Clark Cole, K.
2017-12-01
Transforming geological data into information that has broad scientific and societal impact is a process fraught with barriers. Data sets and tools are often reported to have poor user experiences (UX) that make scientific work more challenging than it needs be. While many other technical fields have benefited from ongoing improvements to the UX of their tools (e.g., healthcare and financial services) scientists are faced with using tools that are labor intensive and not intuitive. Our research team has been involved in a multi-year effort to understand and improve the UX of scientific tools and data sets. We use a User-Centered Design (UCD) process that involves naturalistic behavioral observation and other qualitative research methods adopted from Human-Computer Interaction (HCI) and related fields. Behavioral observation involves having users complete common tasks on data sets, tools, and websites to identify usability issues and understand the severity of the issues. We measure how successfully they complete tasks and diagnosis the cause of any failures. Behavioral observation is paired with in-depth interviews where users describe their process for generating results (from initial inquiry to final results). By asking detailed questions we unpack common patterns and challenges scientists experience while working with data. We've found that tools built using the UCD process can have a large impact on scientist work flows and greatly reduce the time it takes to process data before analysis. It is often challenging to understand the organization and nuances of data across scientific fields. By better understanding how scientists work we can create tools that make routine tasks less-labor intensive, data easier to find, and solve common issues with discovering new data sets and engaging in interdisciplinary research. There is a tremendous opportunity for advancing scientific knowledge and helping the public benefit from that work by creating intuitive, interactive
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Directory of Open Access Journals (Sweden)
О. A. Yeremchenko
2016-01-01
Full Text Available One of the primary challengesRussiais currently facing is the need for diversification of the Russian economy and its increase in the share of manufacturing and exported scientific-driven work products. In this light, improving the effectiveness of the scientific-technological complex of the country is becoming increasingly important. The article considers two scalable, developed in parallel, projects for increasing effectiveness of the scientificresearch sector: restructurization of the scientific organizations network and the project for bringing back home 15 thousand Russian scientists reverse immigration. A conclusion is made about the adequacy of a refusal from a large-scale change in the personnel of scientists in circumstances of when the budget for research and development and the number of scientific-research organizations is cut. It is proposed to create comfortable conditions for scientific search for all parties involved in the process of new knowledge creation, both for the scientists returning toRussiaand those that remain working in the country.
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I Like, I Cite? Do Facebook Likes Predict the Impact of Scientific Work?
Ringelhan, Stefanie; Wollersheim, Jutta; Welpe, Isabell M.
2015-01-01
Due to the increasing amount of scientific work and the typical delays in publication, promptly assessing the impact of scholarly work is a huge challenge. To meet this challenge, one solution may be to create and discover innovative indicators. The goal of this paper is to investigate whether Facebook likes for unpublished manuscripts that are uploaded to the Internet could be used as an early indicator of the future impact of the scientific work. To address our research question, we compared Facebook likes for manuscripts uploaded to the Harvard Business School website (Study 1) and the bioRxiv website (Study 2) with traditional impact indicators (journal article citations, Impact Factor, Immediacy Index) for those manuscripts that have been published as a journal article. Although based on our full sample of Study 1 (N = 170), Facebook likes do not predict traditional impact indicators, for manuscripts with one or more Facebook likes (n = 95), our results indicate that the more Facebook likes a manuscript receives, the more journal article citations the manuscript receives. In additional analyses (for which we categorized the manuscripts as psychological and non-psychological manuscripts), we found that the significant prediction of citations stems from the psychological and not the non-psychological manuscripts. In Study 2, we observed that Facebook likes (N = 270) and non-zero Facebook likes (n = 84) do not predict traditional impact indicators. Taken together, our findings indicate an interdisciplinary difference in the predictive value of Facebook likes, according to which Facebook likes only predict citations in the psychological area but not in the non-psychological area of business or in the field of life sciences. Our paper contributes to understanding the possibilities and limits of the use of social media indicators as potential early indicators of the impact of scientific work. PMID:26244779
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I Like, I Cite? Do Facebook Likes Predict the Impact of Scientific Work?
Ringelhan, Stefanie; Wollersheim, Jutta; Welpe, Isabell M
2015-01-01
Due to the increasing amount of scientific work and the typical delays in publication, promptly assessing the impact of scholarly work is a huge challenge. To meet this challenge, one solution may be to create and discover innovative indicators. The goal of this paper is to investigate whether Facebook likes for unpublished manuscripts that are uploaded to the Internet could be used as an early indicator of the future impact of the scientific work. To address our research question, we compared Facebook likes for manuscripts uploaded to the Harvard Business School website (Study 1) and the bioRxiv website (Study 2) with traditional impact indicators (journal article citations, Impact Factor, Immediacy Index) for those manuscripts that have been published as a journal article. Although based on our full sample of Study 1 (N = 170), Facebook likes do not predict traditional impact indicators, for manuscripts with one or more Facebook likes (n = 95), our results indicate that the more Facebook likes a manuscript receives, the more journal article citations the manuscript receives. In additional analyses (for which we categorized the manuscripts as psychological and non-psychological manuscripts), we found that the significant prediction of citations stems from the psychological and not the non-psychological manuscripts. In Study 2, we observed that Facebook likes (N = 270) and non-zero Facebook likes (n = 84) do not predict traditional impact indicators. Taken together, our findings indicate an interdisciplinary difference in the predictive value of Facebook likes, according to which Facebook likes only predict citations in the psychological area but not in the non-psychological area of business or in the field of life sciences. Our paper contributes to understanding the possibilities and limits of the use of social media indicators as potential early indicators of the impact of scientific work.
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Data Friction Meets Social Friction: Challenges for standardization in emerging fields of geoscience
Darch, P. T.
2017-12-01
Many interdisciplinary endeavors in the geosciences occur in emergent scientific fields. These fields are often characterized by heterogeneity of methods for production and collection of data, and by data scarcity. This paper presents findings about processes of methods standardization from a long-term case study of an emergent, data-scarce field, the deep subseafloor biosphere. Researchers come from many physical and life science backgrounds to study interactions between microbial life in the seafloor and the physical environment they inhabit. Standardization of methods for collecting data promises multiple benefits to this field, including: Addressing data scarcity through enabling greater data reuse and promoting better interoperability with large scale infrastructures; Fostering stronger collaborative links between researchers distributed across institutions and backgrounds. Ongoing standardization efforts in the field do not only involve scientific judgments about which among a range of methods is most efficient, least biased, or most reliable. Instead, these efforts also encounter multiple difficult social challenges, including: Lack of agreed upon criteria about how to judge competing methods: should efficiency, bias, or reliability take priority?; Lack of resources to carry out the work necessary to determine standards, particularly acute in emergent fields; Concerns that standardization is premature in such a new field, foreclosing the possibility of better methods being developed in the future; Concerns that standardization could prematurely shut down important scientific debates; Concerns among some researchers that their own work may become obsolete should the methods chosen as standard be different from their own. The success of these standardization efforts will depend on addressing both scientific and social dimensions, to ensure widespread acceptance among researchers in the field.
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From Comparison Between Scientists to Gaining Cultural Scientific Knowledge. Leonardo and Galileo
Galili, Igal
2016-03-01
Physics textbooks often present items of disciplinary knowledge in a sequential order of topics of the theory under instruction. Such presentation is usually univocal, that is, isolated from alternative claims and contributions regarding the subject matter in the pertinent scientific discourse. We argue that comparing and contrasting the contributions of scientists addressing similar or the same subject could not only enrich the picture of scientific enterprise, but also possess a special appealing power promoting genuine understanding of the concept considered. This approach draws on the historical tradition from Plutarch in distant past and Koyré in the recent history and philosophy of science. It gains a new support in the discipline-culture structuring of the physics curriculum, seeking cultural content knowledge (CCK) of the subject matter. Here, we address two prominent individuals of Italian Renaissance, Leonardo and Galileo, in their dealing with issues relevant for introductory science courses. Although both figures addressed similar subjects of scientific content, their products were essentially different. Considering this difference is educationally valuable, illustrating the meaning of what students presently learn in the content knowledge of mechanics, optics and astronomy, as well as the nature of science and scientific knowledge.
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Social behavioural epistemology and the scientific community.
Watve, Milind
2017-07-01
The progress of science is influenced substantially by social behaviour of and social interactions within the scientific community. Similar to innovations in primate groups, the social acceptance of an innovation depends not only upon the relevance of the innovation but also on the social dominance and connectedness of the innovator. There are a number of parallels between many well-known phenomena in behavioural evolution and various behavioural traits observed in the scientific community. It would be useful, therefore, to use principles of behavioural evolution as hypotheses to study the social behaviour of the scientific community. I argue in this paper that a systematic study of social behavioural epistemology is likely to boost the progress of science by addressing several prevalent biases and other problems in scientific communication and by facilitating appropriate acceptance/rejection of novel concepts.
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Assessing what to address in science communication.
Bruine de Bruin, Wändi; Bostrom, Ann
2013-08-20
As members of a democratic society, individuals face complex decisions about whether to support climate change mitigation, vaccinations, genetically modified food, nanotechnology, geoengineering, and so on. To inform people's decisions and public debate, scientific experts at government agencies, nongovernmental organizations, and other organizations aim to provide understandable and scientifically accurate communication materials. Such communications aim to improve people's understanding of the decision-relevant issues, and if needed, promote behavior change. Unfortunately, existing communications sometimes fail when scientific experts lack information about what people need to know to make more informed decisions or what wording people use to describe relevant concepts. We provide an introduction for scientific experts about how to use mental models research with intended audience members to inform their communication efforts. Specifically, we describe how to conduct interviews to characterize people's decision-relevant beliefs or mental models of the topic under consideration, identify gaps and misconceptions in their knowledge, and reveal their preferred wording. We also describe methods for designing follow-up surveys with larger samples to examine the prevalence of beliefs as well as the relationships of beliefs with behaviors. Finally, we discuss how findings from these interviews and surveys can be used to design communications that effectively address gaps and misconceptions in people's mental models in wording that they understand. We present applications to different scientific domains, showing that this approach leads to communications that improve recipients' understanding and ability to make informed decisions.
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Mapping the evolution of scientific ideas
Energy Technology Data Exchange (ETDEWEB)
Roberts, David C [Los Alamos National Laboratory; Herrera, Mark [UNIV OF MARYLAND; Gulbahce, Natali [NORTHEASTERN UNIV
2008-01-01
The importance of interdisciplinary research is ever increasing as challenging world problems require expertise across diverse fields. Despite the apparent conceptual boundaries of scientific fields, a formal description for their evolution is lacking. Here we describe a novel approach to study the dynamics and evolution of scientific ideas and fields using a network-based analysis. We build a idea network consisting of American Physical Society Pacs numbers as nodes representing scientific concepts. Two Pacs numbers are linked in the network if there exist publications that reference them simultaneously. We locate scientific fields using an overlapping community finding algorithm and describe the time evolution of these fields using a community evolution method over the course of 1985-2006. We find that the communities we find map to scientific fields, the lifetime of these fields strongly depends on their size, impact and activity, and longest living communities are least volatile. The described approach to quantify the evolution of ideas is expected to be relevant in making predictions about the future of science and how to guide its development.
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Halkier, Bente
2015-08-13
Public communication initiatives play a part in placing complicated scientific claims in citizen-consumers' everyday contexts. Lay reactions to scientific claims framed in public communication, and attempts to engage citizens, have been important subjects of discussion in the literatures of public understanding and public engagement with science. Many of the public communication initiatives, however, address lay people as consumers rather than citizens. This creates specific challenges for understanding public engagement with science and scientific citizenship. The article compares five different understandings of the relations between citizen-consumers and public issue communication involving science, where the first four types are widely represented in the Public Understanding of Science discussions. The fifth understanding is a practice theoretical perspective. The article suggests how the public understanding of and engagement in science literature can benefit from including a practice theoretical approach to research about mundane science use and public engagement. © The Author(s) 2015.
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Load Balancing Scientific Applications
Energy Technology Data Exchange (ETDEWEB)
Pearce, Olga Tkachyshyn [Texas A & M Univ., College Station, TX (United States)
2014-12-01
The largest supercomputers have millions of independent processors, and concurrency levels are rapidly increasing. For ideal efficiency, developers of the simulations that run on these machines must ensure that computational work is evenly balanced among processors. Assigning work evenly is challenging because many large modern parallel codes simulate behavior of physical systems that evolve over time, and their workloads change over time. Furthermore, the cost of imbalanced load increases with scale because most large-scale scientific simulations today use a Single Program Multiple Data (SPMD) parallel programming model, and an increasing number of processors will wait for the slowest one at the synchronization points. To address load imbalance, many large-scale parallel applications use dynamic load balance algorithms to redistribute work evenly. The research objective of this dissertation is to develop methods to decide when and how to load balance the application, and to balance it effectively and affordably. We measure and evaluate the computational load of the application, and develop strategies to decide when and how to correct the imbalance. Depending on the simulation, a fast, local load balance algorithm may be suitable, or a more sophisticated and expensive algorithm may be required. We developed a model for comparison of load balance algorithms for a specific state of the simulation that enables the selection of a balancing algorithm that will minimize overall runtime.
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Addressing techniques of liquid crystal displays
Ruckmongathan, Temkar N
2014-01-01
Unique reference source that can be used from the beginning to end of a design project to aid choosing an appropriate LCD addressing technique for a given application This book will be aimed at design engineers who are likely to embed LCD drivers and controllers in many systems including systems on chip. Such designers face the challenge of making the right choice of an addressing technique that will serve them with best performance at minimal cost and complexity. Readers will be able to learn about various methods available for driving matrix LCDs and the comparisons at the end of each chap
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Myth of reincarnation: a challenge for mental health profession.
Gadit, A A Muhammad
2009-02-01
Mental health practitioners often come across a number of challenges in their clinical practice. One such challenge that posed a management dilemma presented with the history of reincarnation. This subject has been discussed in non-scientific literature at length but there is an absolute paucity in scientific literature. This paper describes a case where a boy presented with memories of previous life that started haunting him and caused significant anxiety. The subject of reincarnation needs extensive research in order to understand and manage the resultant clinical challenges.
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Addressing Sexual Violence as Student Affairs Work
Landreman, Lisa M.; Williamsen, Kaaren M.
2018-01-01
In this chapter, we outline the challenges campuses face in addressing sexual violence and Title IX compliance. We argue that there are critical roles for student affairs professionals in Title IX work in developing effective campus sexual violence prevention and response strategies.
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Hurren, Emily; Stewart, Anna; Dennison, Susan
2017-09-15
Administrative data are crucial to the "big data" revolution of social science and have played an important role in the development of child maltreatment research. These data are also of value to administrators, policy makers, and clinicians. The focus of this paper is the use of administrative data to produce and replicate longitudinal studies of child maltreatment. Child protection administrative data have several advantages. They are often population-based, and allow longitudinal examination of child maltreatment and complex multi-level analyses. They also allow comparison across subgroups and minority groups, remove burden from individuals to disclose traumatic experiences, and can be less biased than retrospective recall. Finally, they can be linked to data from other agencies to explore comorbidity and outcomes, and are comparatively cost and time effective. The benefits and challenges associated with the use of administrative data for longitudinal child maltreatment research become magnified when these data are used to produce replications. Techniques to address challenges and support future replication efforts include developing a biographical understanding of the systems from which the data are drawn, using multiple data sources to contextualize the data and research results, recognizing and adopting various approaches to replication, and documenting all data coding and manipulation processes. These techniques are illustrated in this paper via a case study of previous replication work.
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International Nuclear Information System (INIS)
Rubel, Oliver; Ahern, Sean; Bethel, E. Wes; Biggin, Mark D.; Childs, Hank; Cormier-Michel, Estelle; DePace, Angela; Eisen, Michael B.; Fowlkes, Charless C.; Geddes, Cameron G.R.; Hagen, Hans; Hamann, Bernd; Huang, Min-Yu; Keranen, Soile V.E.; Knowles, David W.; Hendriks, Chris L. Luengo; Malik, Jitendra; Meredith, Jeremy; Messmer, Peter; Prabhat; Ushizima, Daniela; Weber, Gunther H.; Wu, Kesheng
2010-01-01
Knowledge discovery from large and complex scientific data is a challenging task. With the ability to measure and simulate more processes at increasingly finer spatial and temporal scales, the growing number of data dimensions and data objects presents tremendous challenges for effective data analysis and data exploration methods and tools. The combination and close integration of methods from scientific visualization, information visualization, automated data analysis, and other enabling technologies 'such as efficient data management' supports knowledge discovery from multi-dimensional scientific data. This paper surveys two distinct applications in developmental biology and accelerator physics, illustrating the effectiveness of the described approach.
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2010 Panel on the Biomaterials Grand Challenges
Reichert, William “Monty”; Ratner, Buddy D.; Anderson, James; Coury, Art; Hoffman, Allan S.; Laurencin, Cato T.; Tirrell, David
2014-01-01
In 2009, the National Academy for Engineering issued the Grand Challenges for Engineering in the 21st Century comprised of 14 technical challenges that must be addressed to build a healthy, profitable, sustainable, and secure global community (http://www.engineeringchallenges.org). Although crucial, none of the NEA Grand Challenges adequately addressed the challenges that face the biomaterials community. In response to the NAE Grand Challenges, Monty Reichert of Duke University organized a panel entitled Grand Challenges in Biomaterials at the at the 2010 Society for Biomaterials Annual Meeting in Seattle. Six members of the National Academies—Buddy Ratner, James Anderson, Allan Hoffman, Art Coury, Cato Laurencin, and David Tirrell—were asked to propose a grand challenge to the audience that, if met, would significantly impact the future of biomaterials and medical devices. Successfully meeting these challenges will speed the 60-plus year transition from commodity, off-the-shelf biomaterials to bioengineered chemistries, and biomaterial devices that will significantly advance our ability to address patient needs and also to create new market opportunities. PMID:21171147
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Rapp, J. R.; Deines, J. M.; Kendall, A. D.; Hyndman, D. W.
2017-12-01
The High Plains Aquifer (HPA) is the most extensively irrigated aquifer in the continental United States and is the largest major aquifer in North America with an area of 500,000 km2. Increased demand for agricultural products has led to expanded irrigation extent, but brought with it declining groundwater levels that have made irrigation unsustainable in some locations. Understanding these irrigation dynamics and mapping irrigated areas through time are essential for future sustainable agricultural practices and hydrological modeling. Map products using remote sensing have only recently been able to track annual dynamics at relatively high spatial resolution (30 m) for a large portion of the northern HPA. However follow-on efforts to expand these maps to the entire HPA have met with difficulty due to the challenge of distinguishing irrigation in crop types that are commonly deficit- or partially-irrigated. Expanding these maps to the full HPA requires addressing unique features of partially irrigated fields and irrigated cotton, a major water user in the southern HPA. Working in Google Earth Engine, we used all available Landsat imagery to generate annual time series of vegetation indices. We combined this information with climate covariables, planting dates, and crop specific training data to algorithmically separate fully irrigated, partially irrigated, and non-irrigated field locations. The classification scheme was then applied to produce annual maps of irrigation across the entire HPA. The extensive use of ancillary data and the "greenness" time series for the algorithmic classification generally increased accuracy relative to previous efforts. High-accuracy, representative map products of irrigation extent capable of detecting crop type and irrigation intensity within aquifers will be an essential tool to monitor the sustainability of global aquifers and to provide a scientific bases for political and economic decisions affecting those aquifers.
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Getting People Involved: The Benefit of Intellectual Capital Management for Addressing HR Challenges
Pook, Katja
2011-01-01
Purpose: This paper aims to explore the benefits of intellectual capital assessment for facing current challenges of human resources work and organizational development. Design/methodology/approach: The paper takes findings of studies on challenges in HR work and maps them with features of intellectual capital assessment methods. It is thus a…
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Biomedical ontologies: toward scientific debate.
Maojo, V; Crespo, J; García-Remesal, M; de la Iglesia, D; Perez-Rey, D; Kulikowski, C
2011-01-01
Biomedical ontologies have been very successful in structuring knowledge for many different applications, receiving widespread praise for their utility and potential. Yet, the role of computational ontologies in scientific research, as opposed to knowledge management applications, has not been extensively discussed. We aim to stimulate further discussion on the advantages and challenges presented by biomedical ontologies from a scientific perspective. We review various aspects of biomedical ontologies going beyond their practical successes, and focus on some key scientific questions in two ways. First, we analyze and discuss current approaches to improve biomedical ontologies that are based largely on classical, Aristotelian ontological models of reality. Second, we raise various open questions about biomedical ontologies that require further research, analyzing in more detail those related to visual reasoning and spatial ontologies. We outline significant scientific issues that biomedical ontologies should consider, beyond current efforts of building practical consensus between them. For spatial ontologies, we suggest an approach for building "morphospatial" taxonomies, as an example that could stimulate research on fundamental open issues for biomedical ontologies. Analysis of a large number of problems with biomedical ontologies suggests that the field is very much open to alternative interpretations of current work, and in need of scientific debate and discussion that can lead to new ideas and research directions.
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Lehr, Jane L.
This dissertation contributes to efforts to rethink the meanings of democracy, scientific literacy, and non-scientist citizenship in the United States. Beginning with questions that emerged from action research and exploring the socio-political forces that shape educational practices, it shows why non-science educators who teach for social justice must first recognize formal science education as a primary site of training for (future) non-scientist citizens and then prepare to intervene in the dominant model of scientifically literate citizenship offered by formal science education. This model of citizenship defines (and limits) appropriate behavior for non-scientist citizens as acquiescing to the authority of science and the state by actively demarcating science from non-science, experts from non-experts, and the rational from the irrational. To question scientific authority is to be scientifically illiterate. This vision of 'acquiescent democracy' seeks to end challenges to the authority of science and the state by ensuring that scientific knowledge is privileged in all personal and public decision-making practices, producing a situation in which it becomes natural for non-scientist citizens to enroll scientific knowledge to naturalize oppression within our schools and society. It suggests that feminist and equity-oriented science educators, by themselves, are unable or unwilling to challenge certain assumptions in the dominant model of scientifically literate citizenship. Therefore, it is the responsibility of non-science educators who teach for social justice to articulate oppositional models of non-scientist citizenship and democracy in their classrooms and to challenge the naturalized authority of scientific knowledge in all aspects of our lives. It demonstrates how research in the field of Science & Technology Studies can serve as one resource in our efforts to intervene in the dominant model of scientifically literate citizenship and to support a model of
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Strategies for Helping Parents of Young Children Address Challenging Behaviors in the Home
Chai, Zhen; Lieberman-Betz, Rebecca
2016-01-01
Challenging behavior can be defined as any repeated pattern of behavior, or perception of behavior, that interferes with or is at risk of interfering with optimal learning or engagement in prosocial interactions with peers and adults. It is generally accepted in young children that challenging behaviors serve some sort of communicative purpose--to…
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Sealfon, C. D.; Plummer, J. D.
2012-08-01
The Women in Aerospace and Technology Project (WATP) is a collaborative effort between the Girl Scouts of Eastern Pennsylvania, the American Helicopter Museum, Boeing Rotorcraft, Sikorsky Global Helicopters, Drexel University, West Chester University, and Arcadia University. The program aims to increase the representation of women in STEM (Science, Technology, Engineering, and Math) fields; the evaluation team identified a secondary goal to assess growth in participants' understanding of scientific inquiry. Girls, grades 4-12, were invited to join Girl Scout troops formed at the American Helicopter Museum to participate in a series of eight workshops on the physics and engineering of flight. Five college women majoring in physics and engineering were recruited as mentors for the girls. Lessons were written by local aerospace industry partners (including Boeing and Sikorsky); the mentors then taught the lessons and activities during the workshops. To evaluate the impact of this project, we collected data to answer two research questions: 1) In what ways does the program impact participants' attitudes towards science and interest in pursuing science as a career? 2) In what ways does the program impact participants' understanding of the nature of scientific inquiry? In this article we summarize results from two sources of data: before and after survey of attitudes about science and end-of-workshop informal questionnaires. Across the seven months of data collection, two challenges became apparent. First, our assessment goals, focusing on scientific interest and inquiry, seemed misaligned with the workshop curricula, which emphasized engineering and design. Secondly, there was little connection among activities within workshops and across the program.
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SciCloud: A Scientific Cloud and Management Platform for Smart City Data
DEFF Research Database (Denmark)
Liu, Xiufeng; Nielsen, Per Sieverts; Heller, Alfred
2017-01-01
private scientific cloud, SciCloud, to tackle these grand challenges. SciCloud provides on-demand computing resource provisions, a scalable data management platform and an in-place data analytics environment to support the scientific research using smart city data....
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Kelly, G.
2015-12-01
Over the past decade, there has been a resurgence of interest in the sustainability of the world's food system and its contributions to feeding the world's population as well as to ensuring environmental sustainability of the planet. The elements of this grand challenge are by now well known. Analysis of agricultural sustainability is made more challenging by the fact that the local responses to these global drivers of change are extremely variable in space and time due to the biophysical and geopolitical heterogeneity across the United States, and the world. Utilizing research networks allows the scientific community to leverage existing knowledge, models and data to develop a framework for understanding the interplay between global change drivers, regional, and continental sustainability of US agriculture. For example, well-established instrumented and calibrated research networks will allow for the examination of the potential tradeoffs between: 1) crop production, 2) land use and carbon emissions and sequestration, 3) groundwater depletion, and 4) nitrogen dynamics. NEON represents a major investment in scientific infrastructure in support of ecological research at a continental scale and is intended to address multiple ecological grand challenges. NEON will collect data from automated sensors and sample organisms and ecological variables in 20 eco-climatic domains. We will provide examples of how NEON's full potential can be realized when these data are combined with long term experimental results and other sensor networks [e.g., Ameriflux, Fluxnet, the Long-term Ecological Research Program (LTER), the Long-term Agroecosystem Research Network (LTAR)], Critical Zone Observatory (CZO).
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The Development of Scientific Thinking in Elementary School: A Comprehensive Inventory
Koerber, Susanne; Mayer, Daniela; Osterhaus, Christopher; Schwippert, Knut; Sodian, Beate
2015-01-01
The development of scientific thinking was assessed in 1,581 second, third, and fourth graders (8-, 9-, 10-year-olds) based on a conceptual model that posits developmental progression from naïve to more advanced conceptions. Using a 66-item scale, five components of scientific thinking were addressed, including experimental design, data…
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Using Grand Challenges to Teach Science: A Biology-Geology Collaboration
Lyford, M.; Myers, J. D.
2012-12-01
Three science courses at the University of Wyoming explore the inextricable connections between science and society by centering on grand challenges. Two of these courses are introductory integrated science courses for non-majors while the third is an upper level course for majors and non-majors. Through collaboration, the authors have developed these courses to explore the grand challenges of energy, water and climate. Each course focuses on the fundamental STEM principles required for a citizen to understand each grand challenge. However, the courses also emphasize the non-STEM perspectives (e.g., economics, politics, human well-being, externalities) that underlie each grand challenge and argue that creating equitable, sustainable and just solutions to the grand challenges hinges on an understanding of STEM and non-STEM perspectives. Moreover, the authors also consider the multitude of personal perspectives individuals bring to the classroom (e.g., values, beliefs, empathy misconceptions) that influence any stakeholder's ability to engage in fruitful discussions about grand challenge solutions. Discovering Science (LIFE 1002) focuses on the grand challenges of energy and climate. Students attend three one-hour lectures, one two-hour lab and a one-hour discussion each week. Lectures emphasize the STEM and non-STEM principles underlying each grand challenge. Laboratory activities are designed to be interdisciplinary and engage students in inquiry-driven activities to reinforce concepts from lecture and to model how science is conducted. Labs also expose students to the difficulties often associated with scientific studies, the limits of science, and the inherent uncertainties associated with scientific findings. Discussion sessions provide an opportunity for students to explore the complexity of the grand challenges from STEM and non-STEM perspectives, and expose the multitude of personal perspectives an individual might harbor related to each grand challenge
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Waller, P; Cassell, J A; Saunders, M H; Stevens, R
2017-03-01
In order to promote understanding of UK governance and assurance relating to electronic health records research, we present and discuss the role of the Independent Scientific Advisory Committee (ISAC) for MHRA database research in evaluating protocols proposing the use of the Clinical Practice Research Datalink. We describe the development of the Committee's activities between 2006 and 2015, alongside growth in data linkage and wider national electronic health records programmes, including the application and assessment processes, and our approach to undertaking this work. Our model can provide independence, challenge and support to data providers such as the Clinical Practice Research Datalink database which has been used for well over 1,000 medical research projects. ISAC's role in scientific oversight ensures feasible and scientifically acceptable plans are in place, while having both lay and professional membership addresses governance issues in order to protect the integrity of the database and ensure that public confidence is maintained.
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Science and Societal Partnerships to Address Cumulative Impacts
Lundquist, Carolyn J.; Fisher, Karen T.; Le Heron, Richard; Lewis, Nick I.; Ellis, Joanne I.; Hewitt, Judi E.; Greenaway, Alison J.; Cartner, Katie J.; Burgess-Jones, Tracey C.; Schiel, David R.; Thrush, Simon F.
2016-01-01
Funding and priorities for ocean research are not separate from the underlying sociological, economic, and political landscapes that determine values attributed to ecological systems. Here we present a variation on science prioritization exercises, focussing on inter-disciplinary research questions with the objective of shifting broad scale management practices to better address cumulative impacts and multiple users. Marine scientists in New Zealand from a broad range of scientific and social...
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Resolving legal, ethical, and human rights challenges in HIV vaccine research.
Patterson, D
2000-01-01
In the absence of a cure for AIDS, attention has turned to the possibility of developing a preventive vaccine for HIV infection. Yet many scientific, ethical, legal, and economic obstacles remain. At the current rate, the development and production of an effective vaccine could take 15 to 20 years or longer. If tens of millions more HIV infections and deaths are to be avoided in the coming decades, vaccine research needs to be greatly expedited. Furthermore, it must be undertaken ethically, and the products of this research must benefit people in developing countries. This article, an edited and updated version of a paper presented at "Putting Third First," addresses challenges arising in HIV preventive vaccine research in developing countries. It does not address clinical research in developing countries relating to treatments or therapeutic vaccines. Nor does it address legal and ethical issues relating to HIV vaccine research in industrialized countries, although similar issues arise in both contexts. The article concludes that while ethical codes are silent on the obligation to undertake research and development, international law provides strong legal obligations--particularly with regard to industrialized states--that should be invoked to accelerate HIV vaccine development, and distribution.
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International Nuclear Information System (INIS)
Candel, Sebastien; Tissot, Bernard; Andre, Jean-Claude; Balian, Roger; Brechet, Yves; Brezin, Edouard; Cesarsky, Catherine; Rebut, Paul-Henri; Jacquinot, Jean; Combarnous, Michel; Pouchard, Michel; Courtillot, Vincent; Jaupart, Claude; Duplessy, Jean-Claude; Laval, Guy; Encrenaz, Pierre; Pironneau, Olivier; Fontecave, Marc; Joliot, Pierre; Guillaumont, Robert; Henry, Claude; Pelegrin, Marc; Roux, Didier; Salencon, Jean; Tarascon, Jean-Marie; Bamberger, Yves; Clement, Daniel; Moisan, Francois; Montagne, Xavier; Singh, Satish
2012-01-01
This report proposes a contribution to the debate on energy, mainly from the point of view of researches to be undertaken to face the successive challenges which will appear within the next decades. The authors starts from the acknowledgement of constraints which are acting on the development of the energy sector: increase of CO 2 emissions leading to an increase of CO 2 in the atmosphere, scarcity of fossil resources, project financing, increased demand of energy (notably electricity), environmental issues, reactions from society, and European and international context. After an overview of the status and perspectives of renewable energies, the report addresses that of fossil energies (shale gas, hydrates of natural gas), nuclear energy (evolution, fourth generation reactors, the ITER project and thermonuclear fusion), vectors and storage (electricity grids, role of hydrogen, energy storage, CO 2 valorization), energy management and saving (energy management in housing and office buildings, proximity mobility of people and goods), and the energy for tomorrow's aeronautics (future characteristics of air transport, aeronautic fuels, oil perspectives and kerosene availability). Appendices address research and development in energy at the international level, the fuel cycle for fast breeders, fusion-fission hybrid reactors, ageing of PWR nuclear power plants, characteristics of lignocellulosic plants)
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Directory of Open Access Journals (Sweden)
D.E. Walling
2014-09-01
Full Text Available The application of fallout radionuclides in soil erosion investigations and related sediment budget studies has provided a widely used tool for improving understanding of soil erosion and sediment transfer processes. However, most studies using fallout radionuclides undertaken to date have focussed on small areas. This focus on small areas reflects both the issues addressed and practical constraints associated with sample collection and analysis. Increasing acceptance of the important role of fine sediment in degrading aquatic habitats and in the transfer and fate of nutrients and contaminants within terrestrial and fluvial systems has emphasised the need to consider larger areas and the catchment or regional scale. The need to upscale existing approaches to the use of fallout radionuclides to larger areas represents an important challenge. This contribution provides a brief review of existing and potential approaches to upscaling the use of fallout radionuclides and presents two examples where such approaches have been successfully applied. These involve a national scale assessment of soil erosion rates in England and Wales based on 137Cs measurements and an investigation of the sediment budgets of three small/intermediate-size catchments in southern Italy.
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The economic scientific research, a production neo-factor
Directory of Open Access Journals (Sweden)
Elena Ciucur
2007-12-01
Full Text Available The scientific research represents a modern production neo-factor that implies two groups of coordinates: preparation and scientific research. The scientific research represents a complex of elements that confer a new orientation of high performance and is materialized in resources and new availabilities brought in active shape by the contribution of the creators and by the attraction in a specific way in the economic circuit. It is the creator of new ideas, lifting the performance and understanding to the highest international standards of competitive economic efficiency. In the present, the role of the scientific research stands before some new challenges generated by the stage of society. It.s propose a unitary, coherent scientific research and educational system, created in corresponding proportions, based on the type, level and utility of the system, by the state, the economic-social environment and the citizen himself.
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Science and society: The benefits of scientific collaboration
2003-01-01
The guest speaker at the next Science and Society symposium is no stranger to CERN. He is, in fact, Sir Chris Llewellyn Smith, Director General of CERN from 1994 to 1998. His topic is one with which he is particularly familiar, having "lived" it throughout his time at CERN: international scientific collaboration and its advantages. International scientific collaboration is essential in a wide range of areas and for a large number of reasons: scientific problems have no frontiers; certain subjects are so complex that they require the expertise of numerous countries; certain types of research, such as that carried out at CERN, cannot be pursued by one nation on its own. However, scientific collaboration is not only beneficial to science itself. This is the point Chris Llewellyn Smith intends to demonstrate in his address. Scientific collaboration can help to build bridges between societies and act as a spur to the development of certain countries. It can even help to diminish conflicts in certain cases. The his...
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Educational NASA Computational and Scientific Studies (enCOMPASS)
Memarsadeghi, Nargess
2013-01-01
Educational NASA Computational and Scientific Studies (enCOMPASS) is an educational project of NASA Goddard Space Flight Center aimed at bridging the gap between computational objectives and needs of NASA's scientific research, missions, and projects, and academia's latest advances in applied mathematics and computer science. enCOMPASS achieves this goal via bidirectional collaboration and communication between NASA and academia. Using developed NASA Computational Case Studies in university computer science/engineering and applied mathematics classes is a way of addressing NASA's goals of contributing to the Science, Technology, Education, and Math (STEM) National Objective. The enCOMPASS Web site at http://encompass.gsfc.nasa.gov provides additional information. There are currently nine enCOMPASS case studies developed in areas of earth sciences, planetary sciences, and astrophysics. Some of these case studies have been published in AIP and IEEE's Computing in Science and Engineering magazines. A few university professors have used enCOMPASS case studies in their computational classes and contributed their findings to NASA scientists. In these case studies, after introducing the science area, the specific problem, and related NASA missions, students are first asked to solve a known problem using NASA data and past approaches used and often published in a scientific/research paper. Then, after learning about the NASA application and related computational tools and approaches for solving the proposed problem, students are given a harder problem as a challenge for them to research and develop solutions for. This project provides a model for NASA scientists and engineers on one side, and university students, faculty, and researchers in computer science and applied mathematics on the other side, to learn from each other's areas of work, computational needs and solutions, and the latest advances in research and development. This innovation takes NASA science and
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Alozie, Nonye M.; Moje, Elizabeth Birr; Krajcik, Joseph S.
2010-01-01
One goal of project-based science is to promote the development of scientific discourse communities in classrooms. Holding rich high school scientific discussions is challenging, especially when the demands of content and norms of high school science pose challenges to their enactment. There is little research on how high school teachers enact…
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Ireland’s Competitiveness Challenge 2014
2014-01-01
Ireland’s Competitiveness Challenge 2014, which is produced under the Action Plan for Jobs 2014, outlines the National Competitiveness Council’s view of the main competitiveness issues confronting the business sector in Ireland over the medium term, and sets out a series of policy responses required to address these challenges. Building on their earlier benchmarking of Irish competitiveness, the Council focus on six major themes in the 2014 report: addressing cost competitiveness; broadening ...
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Proceedings of the scientific visit on crystalline rock repository development.
Energy Technology Data Exchange (ETDEWEB)
Mariner, Paul E.; Hardin, Ernest L.; Miksova, Jitka [RAWRA, Czech Republic
2013-02-01
A scientific visit on Crystalline Rock Repository Development was held in the Czech Republic on September 24-27, 2012. The visit was hosted by the Czech Radioactive Waste Repository Authority (RAWRA), co-hosted by Sandia National Laboratories (SNL), and supported by the International Atomic Energy Agency (IAEA). The purpose of the visit was to promote technical information exchange between participants from countries engaged in the investigation and exploration of crystalline rock for the eventual construction of nuclear waste repositories. The visit was designed especially for participants of countries that have recently commenced (or recommenced) national repository programmes in crystalline host rock formations. Discussion topics included repository programme development, site screening and selection, site characterization, disposal concepts in crystalline host rock, regulatory frameworks, and safety assessment methodology. Interest was surveyed in establishing a %E2%80%9Cclub,%E2%80%9D the mission of which would be to identify and address the various technical challenges that confront the disposal of radioactive waste in crystalline rock environments. The idea of a second scientific visit to be held one year later in another host country received popular support. The visit concluded with a trip to the countryside south of Prague where participants were treated to a tour of the laboratory and underground facilities of the Josef Regional Underground Research Centre.
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ICTP: A Successful Model of International Scientific Collaboration
CERN. Geneva
2012-01-01
The importance of international scientific collaboration in the changing world where the centre of gravity of fundamental research may be moving towards the east and the south is addressed. The unique role of ICTP in supporting global science is highlighted.
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Research on the development of scientific and technological intelligence in big data environment
Directory of Open Access Journals (Sweden)
Wu Qiong
2018-01-01
development of scientific and technological intelligence and problems faced by the big data intelligence system. Finally, the author has predicted the opportunities and challenges for scientific and technological intelligence service agency posed by the big data.
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Which Scientific Knowledge is a Common Good?
Radder, Hans
2017-01-01
In this article, I address the question of whether science can and should be seen as a common good. For this purpose, the first section focuses on the notion of (scientific) knowledge and examines its main characteristics. I discuss and assess the core view of analytic epistemology, that knowledge
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Educational and Scientific Applications of Climate Model Diagnostic Analyzer
Lee, S.; Pan, L.; Zhai, C.; Tang, B.; Kubar, T. L.; Zhang, J.; Bao, Q.
2016-12-01
Climate Model Diagnostic Analyzer (CMDA) is a web-based information system designed for the climate modeling and model analysis community to analyze climate data from models and observations. CMDA provides tools to diagnostically analyze climate data for model validation and improvement, and to systematically manage analysis provenance for sharing results with other investigators. CMDA utilizes cloud computing resources, multi-threading computing, machine-learning algorithms, web service technologies, and provenance-supporting technologies to address technical challenges that the Earth science modeling and model analysis community faces in evaluating and diagnosing climate models. As CMDA infrastructure and technology have matured, we have developed the educational and scientific applications of CMDA. Educationally, CMDA supported the summer school of the JPL Center for Climate Sciences for three years since 2014. In the summer school, the students work on group research projects where CMDA provide datasets and analysis tools. Each student is assigned to a virtual machine with CMDA installed in Amazon Web Services. A provenance management system for CMDA is developed to keep track of students' usages of CMDA, and to recommend datasets and analysis tools for their research topic. The provenance system also allows students to revisit their analysis results and share them with their group. Scientifically, we have developed several science use cases of CMDA covering various topics, datasets, and analysis types. Each use case developed is described and listed in terms of a scientific goal, datasets used, the analysis tools used, scientific results discovered from the use case, an analysis result such as output plots and data files, and a link to the exact analysis service call with all the input arguments filled. For example, one science use case is the evaluation of NCAR CAM5 model with MODIS total cloud fraction. The analysis service used is Difference Plot Service of
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Academic Research Library as Broker in Addressing Interoperability Challenges for the Geosciences
Smith, P., II
2015-12-01
Data capture is an important process in the research lifecycle. Complete descriptive and representative information of the data or database is necessary during data collection whether in the field or in the research lab. The National Science Foundation's (NSF) Public Access Plan (2015) mandates the need for federally funded projects to make their research data more openly available. Developing, implementing, and integrating metadata workflows into to the research process of the data lifecycle facilitates improved data access while also addressing interoperability challenges for the geosciences such as data description and representation. Lack of metadata or data curation can contribute to (1) semantic, (2) ontology, and (3) data integration issues within and across disciplinary domains and projects. Some researchers of EarthCube funded projects have identified these issues as gaps. These gaps can contribute to interoperability data access, discovery, and integration issues between domain-specific and general data repositories. Academic Research Libraries have expertise in providing long-term discovery and access through the use of metadata standards and provision of access to research data, datasets, and publications via institutional repositories. Metadata crosswalks, open archival information systems (OAIS), trusted-repositories, data seal of approval, persistent URL, linking data, objects, resources, and publications in institutional repositories and digital content management systems are common components in the library discipline. These components contribute to a library perspective on data access and discovery that can benefit the geosciences. The USGS Community for Data Integration (CDI) has developed the Science Support Framework (SSF) for data management and integration within its community of practice for contribution to improved understanding of the Earth's physical and biological systems. The USGS CDI SSF can be used as a reference model to map to Earth
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Technical democracy as a challenge to urban studies
DEFF Research Database (Denmark)
Farías, Ignacio; Blok, Anders
2016-01-01
What is technical democracy? And why does it matter for urban studies? As an introduction to this special feature, we address these questions by reflecting on To Our Friends, the 2014 manifesto of the Invisible Committee. We engage in particular its provocative diagnosis of the current situation......: power no longer resides in the modern institutions of representative democracy and the market economy; instead, power has become a matter of logistics, infrastructures and expertise. This diagnosis, we suggest, brings into view the challenge of technical democracy, that is, the democratization of techno......-scientific expertise and the instauration of forms of lasting collaboration among experts and laypeople. Urban politics, we claim, increasingly turns around socio-technical controversies and it is in terms of the politics of expertise that we should analyse and engage it. Building on Science and Technology Studies...
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Intelligent Tools for Building a Scientific Information Platform
Skonieczny, Lukasz; Rybiński, Henryk; Niezgodka, Marek
2012-01-01
This book is a selection of results obtained within one year of research performed under SYNAT - a nation-wide scientific project aiming to create an infrastructure for scientific content storage and sharing for academia, education and open knowledge society in Poland. The selection refers to the research in artificial intelligence, knowledge discovery and data mining, information retrieval and natural language processing, addressing the problems of implementing intelligent tools for building a scientific information platform. The idea of this book is based on the very successful SYNAT Project Conference and the SYNAT Workshop accompanying the 19th International Symposium on Methodologies for Intelligent Systems (ISMIS 2011). The papers included in this book present an overview and insight into such topics as architecture of scientific information platforms, semantic clustering, ontology-based systems, as well as, multimedia data processing.
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The Office of Science Data-Management Challenge
Energy Technology Data Exchange (ETDEWEB)
Mount, Richard P.; /SLAC
2005-10-10
Science--like business, national security, and even everyday life--is becoming more and more data intensive. In some sciences the data-management challenge already exceeds the compute-power challenge in its needed resources. Leadership in applying computing to science will necessarily require both world-class computing and world-class data management. The Office of Science program needs a leadership-class capability in scientific data management. Currently two-thirds of Office of Science research and development in data management is left to the individual scientific programs. About $18M/year is spent by the programs on data-management research and development targeted at their most urgent needs. This is to be compared with the $9M/year spent on data management by DOE computer science. This highly mission-directed approach has been effective, but only in meeting just the highest-priority needs of individual programs. A coherent, leadership-class, program of data management is clearly warranted by the scale and nature of the Office of Science programs. More directly, much of the Office of Science portfolio is in desperate need of such a program; without it, data management could easily become the primary bottleneck to scientific progress within the next five years. When grouped into simulation-intensive science, experiment/observation-intensive science, and information-intensive science, the Office of Science programs show striking commonalities in their data-management needs. Not just research and development but also packaging and hardening as well as maintenance and support are required. Meeting these needs is a medium- to long-term effort requiring a well-planned program of evolving investment. We propose an Office of Science Data-Management Program at an initial scale of $32M/year of new funding. The program should be managed by a Director charged with creating and maintaining a forward-looking approach to multiscience data-management challenges. The program
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Assessing the scientific relevance of a single publication over time
Directory of Open Access Journals (Sweden)
Philipp A. Bloching
2013-09-01
Full Text Available Quantitatively assessing the scientific relevance of a research paper is challenging for two reasons. Firstly, scientific relevance may change over time, and secondly, it is unclear how to evaluate a recently published paper. The temporally averaged paper-specific impact factor is defined as the yearly average of citations to the paper until now including bonus citations equal to the journal impact factor in the publication year. This new measure subsequently allows relevance rankings and annual updates of all (i.e. both recent and older scientific papers of a department, or even a whole scientific field, on a more objective basis. It can also be used to assess both the average and overall time-dependent scientific relevance of researchers in a specific department or scientific field.
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Eijck, van M.W.
2010-01-01
Science education reform must anticipate the scientific literacy required by the next generation of citizens. Particularly, this counts for rapidly emerging and evolving scientific disciplines such as genomics. Taking this discipline as a case, such anticipation is becoming increasingly problematic
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C Versus Fortran-77 for Scientific Programming
Directory of Open Access Journals (Sweden)
Tom MacDonald
1992-01-01
Full Text Available The predominant programming language for numeric and scientific applications is Fortran-77 and supercomputers are primarily used to run large-scale numeric and scientific applications. Standard C* is not widely used for numerical and scientific programming, yet Standard C provides many desirable linguistic features not present in Fortran-77. Furthermore, the existence of a standard library and preprocessor eliminates the worst portability problems. A comparison of Standard C and Fortran-77 shows several key deficiencies in C that reduce its ability to adequately solve some numerical problems. Some of these problems have already been addressed by the C standard but others remain. Standard C with a few extensions and modifications could be suitable for all numerical applications and could become more popular in supercomputing environments.
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6th Annual Scientific Meeting on Challenges of Quality Assurance in Radiation Medicine. Abstracts
International Nuclear Information System (INIS)
2012-01-01
Thai Medical Physicist Society was officially founded in the year 2001 with the purpose of the promotion of the cooperation and communication between medical physicists in Thailand. The main purpose is to organize the Scientific Conferences, Meetings or Courses with other scientific organizations. There are currently about 150 members of Society. This meeting was prepared in cooperation with Naresuan University, to bring a meeting of the highest scientific and educational quality. 9 Invited lectures, 2 workshops and 3 Proffered paper sessions of 25 presentations are arranged. While attending the meeting, the participants will have the best opportunity to learn and share new information and recent advance of medical physics, radiology and other relevant fields through lectures, symposium, workshop from distinguished invited speakers, oral presentations and commercial exhibition of advanced products.
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Enhancing Scientific Foundations to Ensure Reproducibility: A New Paradigm.
Hsieh, Terry; Vaickus, Max H; Remick, Daniel G
2018-01-01
Progress in science is dependent on a strong foundation of reliable results. The publish or perish paradigm in research, coupled with an increase in retracted articles from the peer-reviewed literature, is beginning to erode the trust of both the scientific community and the public. The NIH is combating errors by requiring investigators to follow new guidelines addressing scientific premise, experimental design, biological variables, and authentication of reagents. Herein, we discuss how implementation of NIH guidelines will help investigators proactively address pitfalls of experimental design and methods. Careful consideration of the variables contributing to reproducibility helps ensure robust results. The NIH, investigators, and journals must collaborate to ensure that quality science is funded, explored, and published. Copyright © 2018 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.
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The ESA Scientific Exploitation of Operational Missions element, first results
Desnos, Yves-Louis; Regner, Peter; Delwart, Steven; Benveniste, Jerome; Engdahl, Marcus; Mathieu, Pierre-Philippe; Gascon, Ferran; Donlon, Craig; Davidson, Malcolm; Pinnock, Simon; Foumelis, Michael; Ramoino, Fabrizio
2016-04-01
SEOM is a program element within the fourth period (2013-2017) of ESA's Earth Observation Envelope Programme (http://seom.esa.int/). The prime objective is to federate, support and expand the international research community that the ERS, ENVISAT and the Envelope programmes have built up over the last 25 years. It aims to further strengthen the leadership of the European Earth Observation research community by enabling them to extensively exploit future European operational EO missions. SEOM will enable the science community to address new scientific research that are opened by free and open access to data from operational EO missions. Based on community-wide recommendations for actions on key research issues, gathered through a series of international thematic workshops and scientific user consultation meetings, a work plan is established and is approved every year by ESA Members States. During 2015 SEOM, Science users consultation workshops have been organized for Sentinel1/3/5P ( Fringe, S3 Symposium and Atmospheric science respectively) , new R&D studies for scientific exploitation of the Sentinels have been launched ( S3 for Science SAR Altimetry and Ocean Color , S2 for Science,) , open-source multi-mission scientific toolboxes have been launched (in particular the SNAP/S1-2-3 Toolbox). In addition two advanced international training courses have been organized in Europe to exploit the new S1-A and S2-A data for Land and Ocean remote sensing (over 120 participants from 25 countries) as well as activities for promoting the first scientific results ( e.g. Chili Earthquake) . In addition the First EO Open Science 2.0 was organised at ESA in October 2015 with 225 participants from 31 countries bringing together young EO scientists and data scientists. During the conference precursor activities in EO Open Science and Innovation were presented, while developing a Roadmap preparing for future ESA scientific exploitation activities. Within the conference, the first
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Scientific Synergy between LSST and Euclid
Rhodes, Jason; Nichol, Robert C.; Aubourg, Éric; Bean, Rachel; Boutigny, Dominique; Bremer, Malcolm N.; Capak, Peter; Cardone, Vincenzo; Carry, Benoît; Conselice, Christopher J.; Connolly, Andrew J.; Cuillandre, Jean-Charles; Hatch, N. A.; Helou, George; Hemmati, Shoubaneh; Hildebrandt, Hendrik; Hložek, Renée; Jones, Lynne; Kahn, Steven; Kiessling, Alina; Kitching, Thomas; Lupton, Robert; Mandelbaum, Rachel; Markovic, Katarina; Marshall, Phil; Massey, Richard; Maughan, Ben J.; Melchior, Peter; Mellier, Yannick; Newman, Jeffrey A.; Robertson, Brant; Sauvage, Marc; Schrabback, Tim; Smith, Graham P.; Strauss, Michael A.; Taylor, Andy; Von Der Linden, Anja
2017-12-01
Euclid and the Large Synoptic Survey Telescope (LSST) are poised to dramatically change the astronomy landscape early in the next decade. The combination of high-cadence, deep, wide-field optical photometry from LSST with high-resolution, wide-field optical photometry, and near-infrared photometry and spectroscopy from Euclid will be powerful for addressing a wide range of astrophysical questions. We explore Euclid/LSST synergy, ignoring the political issues associated with data access to focus on the scientific, technical, and financial benefits of coordination. We focus primarily on dark energy cosmology, but also discuss galaxy evolution, transient objects, solar system science, and galaxy cluster studies. We concentrate on synergies that require coordination in cadence or survey overlap, or would benefit from pixel-level co-processing that is beyond the scope of what is currently planned, rather than scientific programs that could be accomplished only at the catalog level without coordination in data processing or survey strategies. We provide two quantitative examples of scientific synergies: the decrease in photo-z errors (benefiting many science cases) when high-resolution Euclid data are used for LSST photo-z determination, and the resulting increase in weak-lensing signal-to-noise ratio from smaller photo-z errors. We briefly discuss other areas of coordination, including high-performance computing resources and calibration data. Finally, we address concerns about the loss of independence and potential cross-checks between the two missions and the potential consequences of not collaborating.
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Böschen, Stefan
2009-07-01
Over the last two decades, there has been a remarkable shift of attention to the scientific and political fundamentals of the precautionary principle. The application of this principle has become a main strategy of coping with the different forms and problems related to non-knowledge. Thus, societies are increasingly confronted with the challenging and hitherto unresolved problem of political and technological decision-making under conditions of diverging framings of non-knowledge. At present, there seems to be no generally accepted scientific or institutional approach. This is why the fundamental question of how different scientific actors define and construct evidence is not answered yet. Hence, this paper is based on the consideration that the conflicts in risk policy concerning genetically modified organisms (GMO) depend on the unresolved conflicts about the diverging scientific strategies and structures of evidence-making between the epistemic cultures involved. Thus, this study investigates two questions: (1) do the epistemic strategies of evidence-making differ systematically with the scientific actors involved in the GMO-debate? (2) What consequences emerge considering institutionalized procedures of decision-making? This article is based on a secondary analysis of findings and perspectives reported in the literature and on the methods of qualitative social empirical research, i.e., interviews with experts. A total number of 34 interviews were conducted to explore the different strategies of handling non-knowledge and constructing evidence. Actors from science, administration, business and NGOs were interviewed. In this way, typical epistemic cultures can be described. An epistemic culture is the constellation of methodological strategies, theoretical assumptions and practical-experimental settings which define in every speciality the ways how we know what we know. There are two main results. Firstly, it was worked out that the epistemic cultures involved
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Narrative Research Addressing the Challenges of a Career in Professional Sports
Frankl, Daniel
2013-01-01
The purpose of this article is to highlight the challenges that accomplished young athletes face as they aspire to become professional athletes. The data used in this study was derived from selected lived and told sport experiences of undergraduate and graduate kinesiology majors who were former competitive athletes. Additional data was derived…
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Addressing challenges in the diagnosis and treatment of rare genetic diseases.
Boycott, Kym M; Ardigó, Diego
2018-03-01
The past 5 years have seen an unprecedented rate of discovery of genes that cause rare diseases and with it a commensurate increase in the number of diagnosable but nevertheless untreatable disorders. Here, we discuss the increasing opportunity for diagnosis and therapy of rare diseases and how to tackle the associated challenges.
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Amplify scientific discovery with artificial intelligence
Energy Technology Data Exchange (ETDEWEB)
Gil, Yolanda; Greaves, Mark T.; Hendler, James; Hirsch, Hyam
2014-10-10
Computing innovations have fundamentally changed many aspects of scientific inquiry. For example, advances in robotics, high-end computing, networking, and databases now underlie much of what we do in science such as gene sequencing, general number crunching, sharing information between scientists, and analyzing large amounts of data. As computing has evolved at a rapid pace, so too has its impact in science, with the most recent computing innovations repeatedly being brought to bear to facilitate new forms of inquiry. Recently, advances in Artificial Intelligence (AI) have deeply penetrated many consumer sectors, including for example Apple’s Siri™ speech recognition system, real-time automated language translation services, and a new generation of self-driving cars and self-navigating drones. However, AI has yet to achieve comparable levels of penetration in scientific inquiry, despite its tremendous potential in aiding computers to help scientists tackle tasks that require scientific reasoning. We contend that advances in AI will transform the practice of science as we are increasingly able to effectively and jointly harness human and machine intelligence in the pursuit of major scientific challenges.
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Built To Last: Using Iterative Development Models for Sustainable Scientific Software Development
Jasiak, M. E.; Truslove, I.; Savoie, M.
2013-12-01
In scientific research, software development exists fundamentally for the results they create. The core research must take focus. It seems natural to researchers, driven by grant deadlines, that every dollar invested in software development should be used to push the boundaries of problem solving. This system of values is frequently misaligned with those of the software being created in a sustainable fashion; short-term optimizations create longer-term sustainability issues. The National Snow and Ice Data Center (NSIDC) has taken bold cultural steps in using agile and lean development and management methodologies to help its researchers meet critical deadlines, while building in the necessary support structure for the code to live far beyond its original milestones. Agile and lean software development and methodologies including Scrum, Kanban, Continuous Delivery and Test-Driven Development have seen widespread adoption within NSIDC. This focus on development methods is combined with an emphasis on explaining to researchers why these methods produce more desirable results for everyone, as well as promoting developers interacting with researchers. This presentation will describe NSIDC's current scientific software development model, how this addresses the short-term versus sustainability dichotomy, the lessons learned and successes realized by transitioning to this agile and lean-influenced model, and the current challenges faced by the organization.
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Complexity-Based Modeling of Scientific Capital: An Outline of Mathematical Theory
Directory of Open Access Journals (Sweden)
Yurij L. Katchanov
2014-01-01
measuring and assessing the accumulated recognition and the specific scientific power. The concept of scientific capital developed by Bourdieu is used in international social science research to explain a set of scholarly properties and practices. Mathematical modeling is applied as a lens through which the scientific capital is addressed. The principal contribution of this paper is an axiomatic characterization of scientific capital in terms of natural axioms. The application of the axiomatic method to scientific capital reveals novel insights into problem still not covered by mathematical modeling. Proposed model embraces the interrelations between separate sociological variables, providing a unified sociological view of science. Suggested microvariational principle is based upon postulate, which affirms that (under suitable conditions the observed state of the agent in scientific field maximizes scientific capital. Its value can be roughly imagined as a volume of social differences. According to the considered macrovariational principle, the actual state of scientific field makes so-called energy functional (which is associated with the distribution of scientific capital minimal.
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VGB-congress power plants 2013. Security of supply - from challenges to solutions. Opening address
International Nuclear Information System (INIS)
Jaeger, Gerd
2014-01-01
The VGB Congress 'Power Plants 2013' took place in Masstricht/NL from September 25 to 27, 2013 under the motto 'Security of Supply - From Challenges to Solutions'. Experts from 31 countries attended the largest European congress for power and heat generation to discuss and inform about current issues. The congress comprised the sections 'Security of Supply: A Common European Challenge', 'Technical Solutions for our Future Electricity Generation', 'Operational Experience as Key Competence' and 'Thinking Ahead: Projects and Visions 2020+' where participants and lecturers dealt with the future challenges of European power supply. (orig.)
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International Nuclear Information System (INIS)
Chu, Steven
2011-01-01
Secretary of Energy Steven Chu gave the keynote address at the 2011 EFRC Summit and Forum. In his talk, Secretary Chu highlighted the need to 'unleash America's science and research community' to achieve energy breakthroughs. The 2011 EFRC Summit and Forum brought together the EFRC community and science and policy leaders from universities, national laboratories, industry and government to discuss 'Science for our Nation's Energy Future.' In August 2009, the Office of Science established 46 Energy Frontier Research Centers. The EFRCs are collaborative research efforts intended to accelerate high-risk, high-reward fundamental research, the scientific basis for transformative energy technologies of the future. These Centers involve universities, national laboratories, nonprofit organizations, and for-profit firms, singly or in partnerships, selected by scientific peer review. They are funded at $2 to $5 million per year for a total planned DOE commitment of $777 million over the initial five-year award period, pending Congressional appropriations. These integrated, multi-investigator Centers are conducting fundamental research focusing on one or more of several 'grand challenges' and use-inspired 'basic research needs' recently identified in major strategic planning efforts by the scientific community. The purpose of the EFRCs is to integrate the talents and expertise of leading scientists in a setting designed to accelerate research that transforms the future of energy and the environment.
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Scientific collaboration: genuine and false motivators
Directory of Open Access Journals (Sweden)
VOLPATO, G. L.
2013-12-01
Full Text Available Here, I emphasize the need for collaborative research among scientists. Such collaboration should aim to address the genuine integrative need to build knowledge rather than searching for visibility based on the international prestige of a collaborator, increased productivity, or funding. Scientists must provide a valid and honest counterpart, such as a solid scientific proposal and performance, and avoid opportunistic motivators.
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EDUCATIONAL BUSINESS IN INDONESIA: ITS SCIENTIFIC QUALITY AND PROFESSIONAL BUSINESS CHALLENGE
Enjang Sudarman
2011-01-01
This study discovers concept and principles to become new theories regarding educational business, study business theories with regard to educational business format, business planning, strategic management, marketing management, financial management and educational business ethics. Some educational business success in Indonesia has executed well by formal and informal organization in university level, study group and courses. This is implicative scientific development and educational busines...
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Directory of Open Access Journals (Sweden)
Marcelo SABBATINI
2016-03-01
Full Text Available The present work analises the main questions and hurdles involved in the adoption of a electronic scientific publication system, those related to the scientific community practices and rules of conduct. We emphasize the quality certification through peer review, interity and legitimiy maintenance and privacity preservation in the digital environment. Furthermore, we analise the academic community own perception of electronic journals available in Internet and its impacts in tenure and prommotion processes.
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Lyons, John S
2009-02-01
The challenges of knowledge translation in behavioural health care are unique to this field for a variety of reasons including the fact that effective treatment is invariably embedded in a strong relationship between practitioners and the people they serve. Practitioners' knowledge gained from experience and intuition become an even more important consideration in the knowledge translation process since clinicians are, in fact, a component of most treatments. Communication of findings from science must be conceptualized with sensitivity to this reality. Considering knowledge translation as a communication process suggests the application of contemporary theories of communication which emphasize the creation of shared meaning over the transmission of knowledge from one person to the next. In this context outcomes management approaches to create a learning environment within clinical practices that facilitate the goals of knowledge transfer while respecting that the scientific enterprise is neither the sole nor primary repository of knowledge.
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Clinical contributions to addressing the social determinants of health.
Patel, Kiran C R; Spilsbury, Peter; Shukla, Rashmi
2010-04-01
The drive to address social determinants of health is gaining momentum. Appreciating that health outcomes are only partly affected by healthcare, clinicians and clinical communities can play a significant role in this crusade by action at local, regional, national and global levels. A concerted and systematic focus on integrating and industrialising upstream interventions at every healthcare encounter is essential to prevent future illness, thus enabling a paradigm shift in the healthcare service from being one of illness management to health preservation. The evidence base demonstrates the cost efficacy of upstream interventions. The challenge is how this evidence is utilised to implement these interventions in everyday healthcare. Today, with a global economic crisis and challenged public sector funding, the need to address prevention has never been more pressing. Clinical engagement at all levels, from the front line to the boardroom is vital. Clinicians must address access, communication, strategy and commissioning to fulfil a professional responsibility to become and remain the corporate memory of a health service focused on preventing illness while simultaneously delivering cost-effective healthcare.
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Touching the Earth: the Role of Art in Scientific Thinking
Cashman, K. V.; Stibbon, E.; Harris, R.
2015-12-01
Historically, geologists have used drawing as a tool not only to record observations but also to engage with the landscape and the materials from which it is constructed. Although geology students are still taught to keep field notebooks, the emphasis on drawing has given way to training in digital tools such as photography and GIS. Has this change altered our perception of our environment, and, thereby, affected the ways that we pursue scientific questions? We address this question through conversations - in the laboratory, studio and field - between artists and scientists that show that we (1) engage with the landscape both rationally and emotionally, (2) are attracted to earth materials because of their form, color, physical qualities and origin/history, (3) overcome technical challenges to realize an end result from an initial idea, (4) struggle to achieve a balance between critical faculties and creative insight, and (5) must communicate ideas, often before they are fully formed, to potential funders. Importantly, we find that the act of rendering (in 2D or 3D), and the ways in which the trace of the hand on paper (or manipulation of clay) engages a part of the brain that is not used in computer-based activities. At the same time, a geological understanding of earth materials enhances their metaphorical applications in the arts. Taken together, these conversations lead us to suggest that more cross-disciplinary training - training scientists in art and artists in science - would not only allow us to explore common themes from different perspectives, but could also create new ways of doing both art and science. Here we provide some examples, such as (1) the importance of drawing for moving from looking to seeing (observation to understanding), (2) ways of engaging perceptions through experimentation, (3) how to reveal the hidden by combining microscopic and macroscopic views of earth materials, and (4) using art as both a language and an interpretive tool
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Scientific Discovery through Advanced Computing in Plasma Science
Tang, William
2005-03-01
Advanced computing is generally recognized to be an increasingly vital tool for accelerating progress in scientific research during the 21st Century. For example, the Department of Energy's ``Scientific Discovery through Advanced Computing'' (SciDAC) Program was motivated in large measure by the fact that formidable scientific challenges in its research portfolio could best be addressed by utilizing the combination of the rapid advances in super-computing technology together with the emergence of effective new algorithms and computational methodologies. The imperative is to translate such progress into corresponding increases in the performance of the scientific codes used to model complex physical systems such as those encountered in high temperature plasma research. If properly validated against experimental measurements and analytic benchmarks, these codes can provide reliable predictive capability for the behavior of a broad range of complex natural and engineered systems. This talk reviews recent progress and future directions for advanced simulations with some illustrative examples taken from the plasma science applications area. Significant recent progress has been made in both particle and fluid simulations of fine-scale turbulence and large-scale dynamics, giving increasingly good agreement between experimental observations and computational modeling. This was made possible by the combination of access to powerful new computational resources together with innovative advances in analytic and computational methods for developing reduced descriptions of physics phenomena spanning a huge range in time and space scales. In particular, the plasma science community has made excellent progress in developing advanced codes for which computer run-time and problem size scale well with the number of processors on massively parallel machines (MPP's). A good example is the effective usage of the full power of multi-teraflop (multi-trillion floating point computations
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Component-based software for high-performance scientific computing
Energy Technology Data Exchange (ETDEWEB)
Alexeev, Yuri; Allan, Benjamin A; Armstrong, Robert C; Bernholdt, David E; Dahlgren, Tamara L; Gannon, Dennis; Janssen, Curtis L; Kenny, Joseph P; Krishnan, Manojkumar; Kohl, James A; Kumfert, Gary; McInnes, Lois Curfman; Nieplocha, Jarek; Parker, Steven G; Rasmussen, Craig; Windus, Theresa L
2005-01-01
Recent advances in both computational hardware and multidisciplinary science have given rise to an unprecedented level of complexity in scientific simulation software. This paper describes an ongoing grass roots effort aimed at addressing complexity in high-performance computing through the use of Component-Based Software Engineering (CBSE). Highlights of the benefits and accomplishments of the Common Component Architecture (CCA) Forum and SciDAC ISIC are given, followed by an illustrative example of how the CCA has been applied to drive scientific discovery in quantum chemistry. Thrusts for future research are also described briefly.
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Component-based software for high-performance scientific computing
International Nuclear Information System (INIS)
Alexeev, Yuri; Allan, Benjamin A; Armstrong, Robert C; Bernholdt, David E; Dahlgren, Tamara L; Gannon, Dennis; Janssen, Curtis L; Kenny, Joseph P; Krishnan, Manojkumar; Kohl, James A; Kumfert, Gary; McInnes, Lois Curfman; Nieplocha, Jarek; Parker, Steven G; Rasmussen, Craig; Windus, Theresa L
2005-01-01
Recent advances in both computational hardware and multidisciplinary science have given rise to an unprecedented level of complexity in scientific simulation software. This paper describes an ongoing grass roots effort aimed at addressing complexity in high-performance computing through the use of Component-Based Software Engineering (CBSE). Highlights of the benefits and accomplishments of the Common Component Architecture (CCA) Forum and SciDAC ISIC are given, followed by an illustrative example of how the CCA has been applied to drive scientific discovery in quantum chemistry. Thrusts for future research are also described briefly
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Directory of Open Access Journals (Sweden)
Gin-Rong Liu Peiwen Lu
2017-01-01
Full Text Available We live in challenging times with a heightened sense of uncertainty and unpredictability. Climate change, with its impact on disruptive events as well as gradual trends, has been addressed in scientific studies and become increasingly important in policymaking. This rises up a great need on scientific integration and knowledge transformation. The Taiwan Integrated Research Programme on Climate Change Adaptation Technology (TaiCCAT is formed under this concern. Directing by the Ministry of Science and Technology (MOST, it carries a strong intention to explore and to conduct adequate knowledge of climate change and adaptation strategies for decision-making supports. The TaiCCAT highly recommends the approach of cross-disciplinary collaboration from environmental studies to adaptation governance. The result can therefore be more contributive to reflect the complexity of the changing world.
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Investigating scientific literacy documents with linguistic network analysis
DEFF Research Database (Denmark)
Bruun, Jesper; Evans, Robert Harry; Dolin, Jens
2009-01-01
International discussions of scientific literacy (SL) are extensive and numerous sizeable documents on SL exist. Thus, comparing different conceptions of SL is methodologically challenging. We developed an analytical tool which couples the theory of complex networks with text analysis in order...
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Full Text Available ... menu It's Only Natural Planning ahead Breastfeeding and baby basics Making breastfeeding work for you Addressing breastfeeding ... in the African-American community Incredible facts about babies, breastmilk, and breastfeeding Overcoming challenges Common questions about ...
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Data Sharing: Convert Challenges into Opportunities.
Figueiredo, Ana Sofia
2017-01-01
Initiatives for sharing research data are opportunities to increase the pace of knowledge discovery and scientific progress. The reuse of research data has the potential to avoid the duplication of data sets and to bring new views from multiple analysis of the same data set. For example, the study of genomic variations associated with cancer profits from the universal collection of such data and helps in selecting the most appropriate therapy for a specific patient. However, data sharing poses challenges to the scientific community. These challenges are of ethical, cultural, legal, financial, or technical nature. This article reviews the impact that data sharing has in science and society and presents guidelines to improve the efficient sharing of research data.
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Selecting and implementing scientific objectives. [for Voyager 1 and 2 planetary encounters
Miner, E. D.; Stembridge, C. H.; Doms, P. E.
1985-01-01
The procedures used to select and implement scientific objectives for the Voyager 1 and 2 planetary encounters are described. Attention is given to the scientific tradeoffs and engineering considerations must be addressed at various stages in the mission planning process, including: the limitations of ground and spacecraft communications systems, ageing of instruments in flight, and instrument calibration over long distances. The contribution of planetary science workshops to the definition of scientific objectives for deep space missions is emphasized.
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Hughes, David J; Kostrzewski, Tomasz; Sceats, Emma L
2017-10-01
Liver disease represents a growing global health burden. The development of in vitro liver models which allow the study of disease and the prediction of metabolism and drug-induced liver injury in humans remains a challenge. The maintenance of functional primary hepatocytes cultures, the parenchymal cell of the liver, has historically been difficult with dedifferentiation and the consequent loss of hepatic function limiting utility. The desire for longer term functional liver cultures sparked the development of numerous systems, including collagen sandwiches, spheroids, micropatterned co-cultures and liver microphysiological systems. This review will focus on liver microphysiological systems, often referred to as liver-on-a-chip, and broaden to include platforms with interconnected microphysiological systems or multi-organ-chips. The interconnection of microphysiological systems presents the opportunity to explore system level effects, investigate organ cross talk, and address questions which were previously the preserve of animal experimentation. As a field, microphysiological systems have reached a level of maturity suitable for commercialization and consequent evaluation by a wider community of users, in academia and the pharmaceutical industry. Here scientific, operational, and organizational considerations relevant to the wider adoption of microphysiological systems will be discussed. Applications in which microphysiological systems might offer unique scientific insights or enable studies currently feasible only with animal models are described, and challenges which might be addressed to enable wider adoption of the technologies are highlighted. A path forward which envisions the development of microphysiological systems in partnerships between academia, vendors and industry, is proposed. Impact statement Microphysiological systems are in vitro models of human tissues and organs. These systems have advanced rapidly in recent years and are now being
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On the impoverishment of scientific education.
Dougherty, Edward R
2013-11-11
Hannah Arendt, one of the foremost political philosophers of the twentieth century, has argued that it is the responsibility of educators not to leave children in their own world but instead to bring them into the adult world so that, as adults, they can carry civilization forward to whatever challenges it will face by bringing to bear the learning of the past. In the same collection of essays, she discusses the recognition by modern science that Nature is inconceivable in terms of ordinary human conceptual categories - as she writes, 'unthinkable in terms of pure reason'. Together, these views on scientific education lead to an educational process that transforms children into adults, with a scientific adult being one who has the ability to conceptualize scientific systems independent of ordinary physical intuition. This article begins with Arendt's basic educational and scientific points and develops from them a critique of current scientific education in conjunction with an appeal to educate young scientists in a manner that allows them to fulfill their potential 'on the shoulders of giants'. While the article takes a general philosophical perspective, its specifics tend to be directed at biomedical education, in particular, how such education pertains to translational science.
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On the impovesrishment of scientific education
2013-01-01
Hannah Arendt, one of the foremost political philosophers of the twentieth century, has argued that it is the responsibility of educators not to leave children in their own world but instead to bring them into the adult world so that, as adults, they can carry civilization forward to whatever challenges it will face by bringing to bear the learning of the past. In the same collection of essays, she discusses the recognition by modern science that Nature is inconceivable in terms of ordinary human conceptual categories - as she writes, ‘unthinkable in terms of pure reason’. Together, these views on scientific education lead to an educational process that transforms children into adults, with a scientific adult being one who has the ability to conceptualize scientific systems independent of ordinary physical intuition. This article begins with Arendt’s basic educational and scientific points and develops from them a critique of current scientific education in conjunction with an appeal to educate young scientists in a manner that allows them to fulfill their potential ‘on the shoulders of giants’. While the article takes a general philosophical perspective, its specifics tend to be directed at biomedical education, in particular, how such education pertains to translational science. PMID:24215841
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Superphenix: technical and scientific achievements
International Nuclear Information System (INIS)
Guidez, Joel; Prele, Gerard
2016-04-01
In this book, the authors propose a synthesis of technical and scientific achievements related to the design, fabrication and eleven-year operation of Superphenix, the most powerful fast breeder reactor ever built and operated. They had the opportunity to use various and important archives maintained by the different involved institutions, actors and companies, such as the CEA with its MADONA database, AREVA and EDF. They address all the different fields: construction, chemistry, exploitation, handling, small and large components, materials, fuel manufacturing, environmental assessment, thermal hydraulics, the sodium-water reaction, sodium fires, the release of residual power, in-service inspection, and dismantling operations. Moreover, a chapter addresses design studies for Superphenix 2 and for the European Fast Reactor (EFR) which should be the successors of Superphenix
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Sanvido, Olivier; Romeis, Jörg; Bigler, Franz
2011-12-01
The ability to decide what kind of environmental changes observed during post-market environmental monitoring of genetically modified (GM) crops represent environmental harm is an essential part of most legal frameworks regulating the commercial release of GM crops into the environment. Among others, such decisions are necessary to initiate remedial measures or to sustain claims of redress linked to environmental liability. Given that consensus on criteria to evaluate 'environmental harm' has not yet been found, there are a number of challenges for risk managers when interpreting GM crop monitoring data for environmental decision-making. In the present paper, we argue that the challenges in decision-making have four main causes. The first three causes relate to scientific data collection and analysis, which have methodological limits. The forth cause concerns scientific data evaluation, which is controversial among the different stakeholders involved in the debate on potential impacts of GM crops on the environment. This results in controversy how the effects of GM crops should be valued and what constitutes environmental harm. This controversy may influence decision-making about triggering corrective actions by regulators. We analyse all four challenges and propose potential strategies for addressing them. We conclude that environmental monitoring has its limits in reducing uncertainties remaining from the environmental risk assessment prior to market approval. We argue that remaining uncertainties related to adverse environmental effects of GM crops would probably be assessed in a more efficient and rigorous way during pre-market risk assessment. Risk managers should acknowledge the limits of environmental monitoring programmes as a tool for decision-making.
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Protection of the environment address book. 2. rev. and enlarged ed.
International Nuclear Information System (INIS)
Winkler, B.
1991-01-01
This manual contains an extensive collection of non-commercial addresses relating to the protection of the environment: The collection includes the government-controlled, communal, scientific associations and groups, regional initiative groups, educational and advisory instances and foundations. When referring to scientific institutes, their main points of activity are given; referring to ecological educational instances, information on their programs is given. For the first time we are also given a list of environment protection authorities, divisions, coordination bureaus which have been set up in communities and big cities and the communal information and advisory programs. (orig.) [de
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Challenges in Managing Trustworthy Large-scale Digital Science
Evans, B. J. K.
2017-12-01
The increased use of large-scale international digital science has opened a number of challenges for managing, handling, using and preserving scientific information. The large volumes of information are driven by three main categories - model outputs including coupled models and ensembles, data products that have been processing to a level of usability, and increasingly heuristically driven data analysis. These data products are increasingly the ones that are usable by the broad communities, and far in excess of the raw instruments data outputs. The data, software and workflows are then shared and replicated to allow broad use at an international scale, which places further demands of infrastructure to support how the information is managed reliably across distributed resources. Users necessarily rely on these underlying "black boxes" so that they are productive to produce new scientific outcomes. The software for these systems depend on computational infrastructure, software interconnected systems, and information capture systems. This ranges from the fundamentals of the reliability of the compute hardware, system software stacks and libraries, and the model software. Due to these complexities and capacity of the infrastructure, there is an increased emphasis of transparency of the approach and robustness of the methods over the full reproducibility. Furthermore, with large volume data management, it is increasingly difficult to store the historical versions of all model and derived data. Instead, the emphasis is on the ability to access the updated products and the reliability by which both previous outcomes are still relevant and can be updated for the new information. We will discuss these challenges and some of the approaches underway that are being used to address these issues.
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Cannabis for Chronic Pain: Challenges and Considerations.
Romero-Sandoval, E Alfonso; Fincham, Jack E; Kolano, Ashley L; Sharpe, Brandi; Alvarado-Vázquez, P Abigail
2018-04-10
The National Academies of Sciences, Engineering, and Medicine has found substantial evidence that cannabis (plant) is effective for the treatment of chronic pain in adults, and moderate evidence that oromucosal cannabinoids (extracts, especially nabiximols) improve short-term sleep disturbances in chronic pain. The paradoxical superiority of the cannabis plant over cannabinoid molecules represents a challenge for the medical community and the established processes that define modern pharmacy. The expanding and variable legalization of cannabis in multiple states nationwide represents an additional challenge for patients and the medical community because recreational and medicinal cannabis are irresponsibly overlapped. Cannabis designed for recreational use (containing high levels of active ingredients) is increasingly available to patients with chronic pain who do not find relief with current pharmacologic entities, which exposes patients to potential harm. This article analyzes the available scientific evidence to address controversial questions that the current state of cannabis poses for health-care professionals and chronic pain patients, and sets the basis for a more open discussion about the role of cannabis in modern medicine for pain management. A critical discussion on these points, the legal status of cannabis, and considerations for healthcare providers is presented. This article is protected by copyright. All rights reserved. This article is protected by copyright. All rights reserved.
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Mobile mental health: a challenging research agenda.
Olff, Miranda
2015-01-01
The field of mobile health ("m-Health") is evolving rapidly and there is an explosive growth of psychological tools on the market. Exciting high-tech developments may identify symptoms, help individuals manage their own mental health, encourage help seeking, and provide both preventive and therapeutic interventions. This development has the potential to be an efficient cost-effective approach reducing waiting lists and serving a considerable portion of people globally ("g-Health"). However, few of the mobile applications (apps) have been rigorously evaluated. There is little information on how valid screening and assessment tools are, which of the mobile intervention apps are effective, or how well mobile apps compare to face-to-face treatments. But how feasible is rigorous scientific evaluation with the rising demands from policy makers, business partners, and users for their quick release? In this paper, developments in m-Health tools-targeting screening, assessment, prevention, and treatment-are reviewed with examples from the field of trauma and posttraumatic stress disorder. The academic challenges in developing and evaluating m-Health tools are being addressed. Evidence-based guidance is needed on appropriate research designs that may overcome some of the public and ethical challenges (e.g., equity, availability) and the market-driven wish to have mobile apps in the "App Store" yesterday rather than tomorrow.
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Clark, Toni A.
2014-01-01
In our day to day lives, the availability of light, with which to see our environment, is often taken for granted. The designers of land based lighting systems use sunlight and artificial light as their toolset. The availability of power, quantity of light sources, and variety of design options are often unlimited. The accessibility of most land based lighting systems makes it easy for the architect and engineer to verify and validate their design ideas. Failures with an implementation, while sometimes costly, can easily be addressed by renovation. Consider now, an architectural facility orbiting in space, 260 miles above the surface of the earth. This human rated architectural facility, the International Space Station (ISS) must maintain operations every day, including life support and appropriate human comforts without fail. The facility must also handle logistics of regular shipments of cargo, including new passengers. The ISS requires accommodations necessary for human control of machine systems. Additionally, the ISS is a research facility and supports investigations performed inside and outside its livable volume. Finally, the facility must support remote operations and observations by ground controllers. All of these architectural needs require a functional, safe, and even an aesthetic lighting environment. At Johnson Space Center, our Habitability and Human Factors team assists our diverse customers with their lighting environment challenges, via physical test and computer based analysis. Because of the complexity of ISS operational environment, our team has learned and developed processes that help ISS operate safely. Because of the dynamic exterior lighting environment, uses computational modeling to predict the lighting environment. The ISS' orbit exposes it to a sunrise every 90 minutes, causing work surfaces to quickly change from direct sunlight to earthshine to total darkness. Proper planning of vehicle approaches, robotics operations, and crewed
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Scientometric Analysis and Mapping of Scientific Articles on Diabetic Retinopathy.
Ramin, Shahrokh; Gharebaghi, Reza; Heidary, Fatemeh
2015-01-01
Diabetic retinopathy (DR) is the major cause of blindness among the working-age population globally. No systematic research has been previously performed to analyze the research published on DR, despite the need for it. This study aimed to analyze the scientific production on DR to draw overall roadmap of future research strategic planning in this field. A bibliometric method was used to obtain a view on the scientific production about DR by the data extracted from the Institute for Scientific Information (ISI). Articles about DR published in 1993-2013 were analyzed to obtain a view of the topic's structure, history, and to document relationships. The trends in the most influential publications and authors were analyzed. Most highly cited articles addressed epidemiologic and translational research topics in this field. During the past 3 years, there has been a trend toward biomarker discovery and more molecular translational research. Areas such as gene therapy and micro-RNAs are also among the recent hot topics. Through analyzing the characteristics of papers and the trends in scientific production, we performed the first scientometric report on DR. Most influential articles have addressed epidemiology and translational research subjects in this field, which reflects that globally, the earlier diagnosis and treatment of this devastating disease still has the highest global priority.
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A Scientific World in a Grain of Sand
Clary, Renee; Wandersee, James
2011-01-01
Students investigate local sand samples on a shoestring budget. This investigation reveals a fascinating Earth history that can address various interdisciplinary scientific topics, provide rich inquiry experiences, and move beyond the science classroom to integrate history, culture, and art. (Contains 3 figures and 14 online resources.)
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Addressing current challenges in cancer immunotherapy with mathematical and computational modelling.
Konstorum, Anna; Vella, Anthony T; Adler, Adam J; Laubenbacher, Reinhard C
2017-06-01
The goal of cancer immunotherapy is to boost a patient's immune response to a tumour. Yet, the design of an effective immunotherapy is complicated by various factors, including a potentially immunosuppressive tumour microenvironment, immune-modulating effects of conventional treatments and therapy-related toxicities. These complexities can be incorporated into mathematical and computational models of cancer immunotherapy that can then be used to aid in rational therapy design. In this review, we survey modelling approaches under the umbrella of the major challenges facing immunotherapy development, which encompass tumour classification, optimal treatment scheduling and combination therapy design. Although overlapping, each challenge has presented unique opportunities for modellers to make contributions using analytical and numerical analysis of model outcomes, as well as optimization algorithms. We discuss several examples of models that have grown in complexity as more biological information has become available, showcasing how model development is a dynamic process interlinked with the rapid advances in tumour-immune biology. We conclude the review with recommendations for modellers both with respect to methodology and biological direction that might help keep modellers at the forefront of cancer immunotherapy development. © 2017 The Author(s).
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Hanford Site Cleanup Challenges and Opportunities for Science and Technology--A Strategic Assessment
Energy Technology Data Exchange (ETDEWEB)
Wood, Thomas W.; Johnson, Wayne L.; Kreid, Dennis K.; Walton, Terry L.
2001-02-01
The sheer expanse of the Hanford Site, the inherent hazards associated with the significant inventory of nuclear materials and wastes, the large number of aging contaminated facilities, the diverse nature and extent of environmental contamination, and the proximity to the Columbia River make Hanford perhaps the world's largest and most complex environmental cleanup project. It is not possible to address the more complex elements of this enormous challenge in a cost-effective manner without strategic investments in science and technology. Success requires vigorous and sustained efforts to enhance the science and technology basis, develop and deploy innovative solutions, and provide firm scientific bases to support site cleanup and closure decisions at Hanford.
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Hanford Site Cleanup Challenges and Opportunities for Science and Technology--A Strategic Assessment
International Nuclear Information System (INIS)
Wood, Thomas W.; Johnson, Wayne L.; Kreid, Dennis K.; Walton, Terry L.
2001-01-01
The sheer expanse of the Hanford Site, the inherent hazards associated with the significant inventory of nuclear materials and wastes, the large number of aging contaminated facilities, the diverse nature and extent of environmental contamination, and the proximity to the Columbia River make Hanford perhaps the world's largest and most complex environmental cleanup project. It is not possible to address the more complex elements of this enormous challenge in a cost-effective manner without strategic investments in science and technology. Success requires vigorous and sustained efforts to enhance the science and technology basis, develop and deploy innovative solutions, and provide firm scientific bases to support site cleanup and closure decisions at Hanford
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United States-Mexican Borderlands: Facing tomorrow's challenges through USGS science
Updike, Randall G.; Ellis, Eugene G.; Page, William R.; Parker, Melanie J.; Hestbeck, Jay B.; Horak, William F.
2013-01-01
Along the nearly 3,200 kilometers (almost 2,000 miles) of the United States–Mexican border, in an area known as the Borderlands, we are witnessing the expression of the challenges of the 21st century. This circular identifies several challenge themes and issues associated with life and the environment in the Borderlands, listed below. The challenges are not one-sided; they do not originate in one country only to become problems for the other. The issues and concerns of each challenge theme flow in both directions across the border, and both nations feel their effects throughout the Borderlands and beyond. The clear message is that our two nations, the United States and Mexico, face the issues in these challenge themes together, and the U.S. Geological Survey (USGS) understands it must work with its counterparts, partners, and customers in both countries.Though the mission of the USGS is not to serve as land manager, law enforcer, or code regulator, its innovation and creativity and the scientific and technical depth of its capabilities can be directly applied to monitoring the conditions of the landscape. The ability of USGS scientists to critically analyze the monitored data in search of signals and trends, whether they lead to negative or positive results, allows us to reach significant conclusions—from providing factual conclusions to decisionmakers, to estimating how much of a natural resource exists in a particular locale, to predicting how a natural hazard phenomenon will unfold, to forecasting on a scale from hours to millennia how ecosystems will behave.None of these challenge themes can be addressed strictly by one or two science disciplines; all require well-integrated, cross-discipline thinking, data collection, and analyses. The multidisciplinary science themes that have become the focus of the USGS mission parallel the major challenges in the border region between Mexico and the United States. Because of this multidisciplinary approach, the USGS
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Energy Technology Data Exchange (ETDEWEB)
Arumugam, Kamesh [Old Dominion Univ., Norfolk, VA (United States)
2017-05-01
Efficient parallel implementations of scientific applications on multi-core CPUs with accelerators such as GPUs and Xeon Phis is challenging. This requires - exploiting the data parallel architecture of the accelerator along with the vector pipelines of modern x86 CPU architectures, load balancing, and efficient memory transfer between different devices. It is relatively easy to meet these requirements for highly structured scientific applications. In contrast, a number of scientific and engineering applications are unstructured. Getting performance on accelerators for these applications is extremely challenging because many of these applications employ irregular algorithms which exhibit data-dependent control-ow and irregular memory accesses. Furthermore, these applications are often iterative with dependency between steps, and thus making it hard to parallelize across steps. As a result, parallelism in these applications is often limited to a single step. Numerical simulation of charged particles beam dynamics is one such application where the distribution of work and memory access pattern at each time step is irregular. Applications with these properties tend to present significant branch and memory divergence, load imbalance between different processor cores, and poor compute and memory utilization. Prior research on parallelizing such irregular applications have been focused around optimizing the irregular, data-dependent memory accesses and control-ow during a single step of the application independent of the other steps, with the assumption that these patterns are completely unpredictable. We observed that the structure of computation leading to control-ow divergence and irregular memory accesses in one step is similar to that in the next step. It is possible to predict this structure in the current step by observing the computation structure of previous steps. In this dissertation, we present novel machine learning based optimization techniques to address
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The global conduct of cancer clinical trials: challenges and opportunities.
Barrios, Carlos H; Werutsky, Gustavo; Martinez-Mesa, Jeovany
2015-01-01
The nature of clinical research has changed substantially over the last 2 decades, evolving from being centered almost exclusively in developed countries to a more global scenario that is increasingly involving less developed regions of the world. Pharmaceutical companies and some academic cooperative groups have been conducting challenging, large pivotal registration studies with multinational participation. The much more needed globalization of academic research demands particular attention and represents a worthwhile subject for a more profound discussion. The requirement of large sample sizes and the potential for fast recruitment leading to a speedy completion of clinical studies are probably the most important factors that have fueled globalization of studies. Reduced operational costs and the ability to expedite the regulatory approval of drugs in various countries or regions are also important drivers. Globalization of research should be seen as having a much wider effect in the societies involved, in particular, when we consider public health, economic, social, and ethical implications. Most importantly, the process of expanding the network of clinical research sites also fosters the integration and the development of closer relationships among investigators at a global level. We consider this an essential element that should remain a prominent element in the discussion. In this article, we address the underlying reasons for globalization and we highlight some of the scientific and ethical concerns arising as a consequence. Finally, some strategies to address and mitigate the challenges of conducting multinational clinical research are proposed.
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Bilham, Nic
2015-04-01
Debate and dissent are at the heart of scientific endeavour. A diversity of perspectives, alternative interpretations of evidence and the robust defence of competing theories and models drive the advancement of scientific knowledge. Just as importantly, legitimate dissent and diversity of views should not be covered up when offering scientific advice to policy-makers and providing evidence to inform public debate - indeed, they should be valued. We should offer what Andy Stirling has termed 'plural and conditional' scientific advice, not just for the sake of democratic legitimacy, but because it supports better informed and more effective policy-making. 'Monocultures' of scientific advice may have a superficial appeal to policy-makers, but they devalue the contribution of scientists, undermine the resilience of regulatory structures, are often misleading, and can lead to catastrophic policy failure. Furthermore, many of the great societal challenges now facing us require interdisciplinary approaches, across the natural sciences and more widely still, which bring to the fore the need for humility, recognition that we do not have all the answers, and mutual respect for the views of others. In contentious areas such as climate change, extraction of shale gas and radioactive waste disposal, however, such open dialogue may make researchers and practitioners vulnerable to advocates and campaigners who cherry-pick the evidence, misinterpret it, or seek to present scientific uncertainty and debate as mere ignorance. Nor are scientists themselves always above such unethical tactics. The apparent authority conferred on unscrupulous 'campaigning scientists' by their academic and professional credentials may make it all but impossible to distinguish them from those who legitimately make the case for a minority scientific view (and may be marginalised by the mainstream of their discipline in doing so). There is a risk that real scientific debate may be thwarted. Individual
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The logical foundations of scientific theories languages, structures, and models
Krause, Decio
2016-01-01
This book addresses the logical aspects of the foundations of scientific theories. Even though the relevance of formal methods in the study of scientific theories is now widely recognized and regaining prominence, the issues covered here are still not generally discussed in philosophy of science. The authors focus mainly on the role played by the underlying formal apparatuses employed in the construction of the models of scientific theories, relating the discussion with the so-called semantic approach to scientific theories. The book describes the role played by this metamathematical framework in three main aspects: considerations of formal languages employed to axiomatize scientific theories, the role of the axiomatic method itself, and the way set-theoretical structures, which play the role of the models of theories, are developed. The authors also discuss the differences and philosophical relevance of the two basic ways of aximoatizing a scientific theory, namely Patrick Suppes’ set theoretical predicate...
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López-Rodríguez, M D; Castro, H; Arenas, M; Requena-Mullor, J M; Cano, A; Valenzuela, E; Cabello, J
2017-12-01
Understanding how to improve decision makers' use of scientific information across their different scales of management is a core challenge for narrowing the gap between science and conservation practice. Here, we present a study conducted in collaboration with decision makers that aims to explore the functionality of the mechanisms for scientific input within the institutional setting of the National Protected Area Network of Peru. First, we analyzed institutional mechanisms to assess the scientific information recorded by decision makers. Second, we developed two workshops involving scientists, decision makers and social actors to identify barriers to evidence-based conservation practice. Third, we administered 482 questionnaires to stakeholders to explore social perceptions of the role of science and the willingness to collaborate in the governance of protected areas. The results revealed that (1) the institutional mechanisms did not effectively promote the compilation and application of scientific knowledge for conservation practice; (2) six important barriers hindered scientific input in management decisions; and (3) stakeholders showed positive perceptions about the involvement of scientists in protected areas and expressed their willingness to collaborate in conservation practice. This collaborative research helped to (1) identify gaps and opportunities that should be addressed for increasing the effectiveness of the institutional mechanisms and (2) support institutional changes integrating science-based strategies for strengthening scientific input in decision-making. These insights provide a useful contextual orientation for scholars and decision makers interested in conducting empirical research to connect scientific inputs with operational aspects of the management cycle in other institutional settings around the world.
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López-Rodríguez, M. D.; Castro, H.; Arenas, M.; Requena-Mullor, J. M.; Cano, A.; Valenzuela, E.; Cabello, J.
2017-12-01
Understanding how to improve decision makers' use of scientific information across their different scales of management is a core challenge for narrowing the gap between science and conservation practice. Here, we present a study conducted in collaboration with decision makers that aims to explore the functionality of the mechanisms for scientific input within the institutional setting of the National Protected Area Network of Peru. First, we analyzed institutional mechanisms to assess the scientific information recorded by decision makers. Second, we developed two workshops involving scientists, decision makers and social actors to identify barriers to evidence-based conservation practice. Third, we administered 482 questionnaires to stakeholders to explore social perceptions of the role of science and the willingness to collaborate in the governance of protected areas. The results revealed that (1) the institutional mechanisms did not effectively promote the compilation and application of scientific knowledge for conservation practice; (2) six important barriers hindered scientific input in management decisions; and (3) stakeholders showed positive perceptions about the involvement of scientists in protected areas and expressed their willingness to collaborate in conservation practice. This collaborative research helped to (1) identify gaps and opportunities that should be addressed for increasing the effectiveness of the institutional mechanisms and (2) support institutional changes integrating science-based strategies for strengthening scientific input in decision-making. These insights provide a useful contextual orientation for scholars and decision makers interested in conducting empirical research to connect scientific inputs with operational aspects of the management cycle in other institutional settings around the world.
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Borg, Jesmond
2017-01-01
This study focuses on the concept of wine tourism as a growing niche on the island of Gozo. Over the last decade, Gozo has seen a synergy between wine and the tourism indus-try which has led to the development of what is commonly known as wine tourism. As in other countries, wine tourism on this small island is leaving an impact on the social and economic aspects. This research aims to portray the success factors and the major challenges that Gozo needs to address to develop the full pot...
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A Formula for Fixing Troubled Projects: The Scientific Method Meets Leadership
Wagner, Sandra
2006-01-01
This presentation focuses on project management, specifically addressing project issues using the scientific method of problem-solving. Two sample projects where this methodology has been applied are provided.
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Work of scientific and technological information under network environment
International Nuclear Information System (INIS)
Chen Yingxi; Huang Daifu; Yang Lifeng
2010-01-01
With the development of internet and information technology, the work of scientific and technological information is faced with great challenge. This article expounds the new changes of scientific and technological information in enterprise under network environment by giving a minute description on the situation the work faced and characteristic of the work. Not only does it carry out enthusiastic discussion upon problems which are present in the work of scientific and technological information in the company, but puts forward proposals and specific measures as well. Service theory is also offered by adjusting and reforming the resources construction, service ways and the job of providing contents. We should take vigorous action to the research work of scientific and technological information, changing the information directional service into knowledge providing service. (authors)
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Addressing the hidden dimension in nursing education: promoting cultural competence.
Carter, Kimberly F; Xu, Yu
2007-01-01
The authors describe a cultural competence quality enhancement process to address the retention challenge of students who speak English as second language and international students as part of a school of nursing's continuous program quality improvement to achieve excellence. The process, strategies, outcomes, and evaluation of the training program are detailed within the given geographical, institutional, and curriculum context. Lessons and continuing challenges are also specified.
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Cummings, Kristina M.
The omnipresence of science and technology in our society require the development of a critical and scientifically literate citizenry. However, the inclusion of socioscientific issues, which are open-ended controversial issues informed by both science and societal factors such as politics, economics, and ethics, do not guarantee the development of these skills. The purpose of this critical discourse analysis is to identify and analyze the discursive strategies used in intermediate science texts and curricula that address socioscientific topics and the extent to which the discourses are designed to promote or suppress the development of scientific literacy and a critical pedagogy. Three curricula that address the issue of energy and climate change were analyzed using Gee's (2011) building tasks and inquiry tools. The curricula were written by an education organization entitled PreSEES, a corporate-sponsored group called NEED, and a non-profit organization named Oxfam. The analysis found that the PreSEES and Oxfam curricula elevated the significance of climate change and the NEED curriculum deemphasized the issue. The PreSEES and Oxfam curricula promoted the development of scientific literacy while the NEED curricula suppressed its development. The PreSEES and Oxfam curricula both promoted the development of the critical pedagogy; however, only the Oxfam curricula provided authentic opportunities to enact sociopolitical change. The NEED curricula suppressed the development of critical pedagogy. From these findings, the following conclusions were drawn. When socioscientific issues are presented with the development of scientific literacy and critical pedagogy, the curricula allow students to develop fact-based opinions about the issue. However, curricula that address socioscientific issues without the inclusion of these skills minimize the significance of the issue and normalize the hegemonic worldview promoted by the curricula's authors. Based on these findings
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Scientific Solutions to Nuclear Waste Environmental Challenges
International Nuclear Information System (INIS)
Johnson, Bradley R.
2014-01-01
The Hidden Cost of Nuclear Weapons The Cold War arms race drove an intense plutonium production program in the U.S. This campaign produced approximately 100 tons of plutonium over 40 years. The epicenter of plutonium production in the United States was the Hanford site, a 586 square mile reservation owned by the Department of Energy and located on the Colombia River in Southeastern Washington. Plutonium synthesis relied on nuclear reactors to convert uranium to plutonium within the reactor fuel rods. After a sufficient amount of conversion occurred, the rods were removed from the reactor and allowed to cool. They were then dissolved in an acid bath and chemically processed to separate and purify plutonium from the rest of the constituents in the used reactor fuel. The acidic waste was then neutralized using sodium hydroxide and the resulting mixture of liquids and precipitates (small insoluble particles) was stored in huge underground waste tanks. The byproducts of the U.S. plutonium production campaign include over 53 million gallons of high-level radioactive waste stored in 177 large underground tanks at Hanford and another 34 million gallons stored at the Savannah River Site in South Carolina. This legacy nuclear waste represents one of the largest environmental clean-up challenges facing the world today. The nuclear waste in the Hanford tanks is a mixture of liquids and precipitates that have settled into sludge. Some of these tanks are now over 60 years old and a small number of them are leaking radioactive waste into the ground and contaminating the environment. The solution to this nuclear waste challenge is to convert the mixture of solids and liquids into a durable material that won't disperse into the environment and create hazards to the biosphere. What makes this difficult is the fact that the radioactive half-lives of some of the radionuclides in the waste are thousands to millions of years long. (The half-life of a radioactive substance is the amount
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Optically addressed ultra-wideband phased antenna array
Bai, Jian
Demands for high data rate and multifunctional apertures from both civilian and military users have motivated development of ultra-wideband (UWB) electrically steered phased arrays. Meanwhile, the need for large contiguous frequency is pushing operation of radio systems into the millimeter-wave (mm-wave) range. Therefore, modern radio systems require UWB performance from VHF to mm-wave. However, traditional electronic systems suffer many challenges that make achieving these requirements difficult. Several examples includes: voltage controlled oscillators (VCO) cannot provide a tunable range of several octaves, distribution of wideband local oscillator signals undergo high loss and dispersion through RF transmission lines, and antennas have very limited bandwidth or bulky sizes. Recently, RF photonics technology has drawn considerable attention because of its advantages over traditional systems, with the capability of offering extreme power efficiency, information capacity, frequency agility, and spatial beam diversity. A hybrid RF photonic communication system utilizing optical links and an RF transducer at the antenna potentially provides ultra-wideband data transmission, i.e., over 100 GHz. A successful implementation of such an optically addressed phased array requires addressing several key challenges. Photonic generation of an RF source with over a seven-octave bandwidth has been demonstrated in the last few years. However, one challenge which still remains is how to convey phased optical signals to downconversion modules and antennas. Therefore, a feed network with phase sweeping capability and low excessive phase noise needs to be developed. Another key challenge is to develop an ultra-wideband array antenna. Modern frontends require antennas to be compact, planar, and low-profile in addition to possessing broad bandwidth, conforming to stringent space, weight, cost, and power constraints. To address these issues, I will study broadband and miniaturization
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Embedding Scientific Integrity and Ethics into the Scientific Process and Research Data Lifecycle
Gundersen, L. C.
2016-12-01
Predicting climate change, developing resources sustainably, and mitigating natural hazard risk are complex interdisciplinary challenges in the geosciences that require the integration of data and knowledge from disparate disciplines and scales. This kind of interdisciplinary science can only thrive if scientific communities work together and adhere to common standards of scientific integrity, ethics, data management, curation, and sharing. Science and data without integrity and ethics can erode the very fabric of the scientific enterprise and potentially harm society and the planet. Inaccurate risk analyses of natural hazards can lead to poor choices in construction, insurance, and emergency response. Incorrect assessment of mineral resources can bankrupt a company, destroy a local economy, and contaminate an ecosystem. This paper presents key ethics and integrity questions paired with the major components of the research data life cycle. The questions can be used by the researcher during the scientific process to help ensure the integrity and ethics of their research and adherence to sound data management practice. Questions include considerations for open, collaborative science, which is fundamentally changing the responsibility of scientists regarding data sharing and reproducibility. The publication of primary data, methods, models, software, and workflows must become a norm of science. There are also questions that prompt the scientist to think about the benefit of their work to society; ensuring equity, respect, and fairness in working with others; and always striving for honesty, excellence, and transparency.
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MonetDB/SQL Meets SkyServer: the Challenges of a Scientific Database.
M.G. Ivanova (Milena); N.J. Nes (Niels); R.A. Goncalves (Romulo); M.L. Kersten (Martin)
2007-01-01
textabstractThis paper presents our experiences in porting the Sloan Digital Sky Survey(SDSS)/ SkyServer to the state-of-the-art open source database system MonetDB/SQL. SDSS acts as a well-documented benchmark for scientific database management. We have achieved a fully functional prototype for the
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Future scientific drilling in the Arctic Ocean: Key objectives, areas, and strategies
Stein, R.; Coakley, B.; Mikkelsen, N.; O'Regan, M.; Ruppel, C.
2012-04-01
In spite of the critical role of the Arctic Ocean in climate evolution, our understanding of the short- and long-term paleoceanographic and paleoclimatic history through late Mesozoic-Cenozoic times, as well as its plate-tectonic evolution, remains behind that from the other world's oceans. This lack of knowledge is mainly caused by the major technological/logistic problems in reaching this permanently ice-covered region with normal research vessels and in retrieving long and undisturbed sediment cores. With the Arctic Coring Expedition - ACEX (or IODP Expedition 302), the first Mission Specific Platform (MSP) expedition within IODP, a new era in Arctic research began (Backman, Moran, Mayer, McInroy et al., 2006). ACEX proved that, with an intensive ice-management strategy, successful scientific drilling in the permanently ice-covered central Arctic Ocean is possible. ACEX is certainly a milestone in Arctic Ocean research, but - of course - further drilling activities are needed in this poorly studied ocean. Furthermore, despite the success of ACEX fundamental questions related to the long- and short-term climate history of the Arctic Ocean during Mesozoic-Cenozoic times remain unanswered. This is partly due to poor core recovery during ACEX and, especially, because of a major mid-Cenozoic hiatus in this single record. Since ACEX, a series of workshops were held to develop a scientific drilling strategy for investigating the tectonic and paleoceanographic history of the Arctic Ocean and its role in influencing the global climate system: - "Arctic Ocean History: From Speculation to Reality" (Bremerhaven/Germany, November 2008); - "Overcoming barriers to Arctic Ocean scientific drilling: the site survey challenge" (Copenhagen/Denmark, November 2011); - Circum-Arctic shelf/upper continental slope scientific drilling workshop on "Catching Climate Change in Progress" (San Francisco/USA, December 2011); - "Coordinated Scientific Drilling in the Beaufort Sea: Addressing
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Addressing chronic operational issues at the W. M. Keck Observatory
Nordin, Tom; Matsuda, Richard
2016-07-01
The W. M. Keck Observatory (WMKO) has a good track record at addressing large critical faults which impact observing. Our performance tracking and correcting chronic minor faults has been mixed, yet this class of problems has a significant negative impact on scientific productivity and staff effectiveness. We have taken steps to address this shortcoming. This paper outlines the creation of a program to identify, categorize and rank these chronic operational issues, track them over time, and develop management options for their resolution. The success of the program at identifying these chronic operational issues and the advantages of dedicating observatory resources to this endeavor are presented.
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Challenges in contemporary academic neurosurgery.
Black, Peter M
2006-03-01
Traditionally, the ideal academic neurosurgeon has been a "quadruple threat," with excellence in clinical work, teaching, research, and administration. This tradition was best exemplified in Harvey Cushing, who developed the field of neurosurgery 90 years ago. This paradigm will probably have to change as academic neurosurgeons face major challenges. In patient care, these include increasing regulatory control, increasing malpractice costs, consolidation of expensive care in academic centers, and decreasing reimbursement; in resident teaching, work hour limitations and a changing resident culture; in research, the increasing dominance of basic scientists in governmental funding decisions and decreased involvement of neurosurgeons in scientific review committees; and in administration, problems of relationships in the workplace, patient safety, and employment compliance in an increasingly bureaucratic system. To meet these challenges, the new academic neurosurgeon will probably not be a quadruple threat personally but will be part of a quadruple threat in a department and institution. Neurosurgeons in such a setting will have to work with hospital, medical school, and national and international groups to address malpractice, reimbursement, subspecialization, and training problems; find supplemental sources of income through grants, development funds, and hospital support; lead in the development of multidisciplinary centers for neuroscience, brain tumor, spine, and other initiatives; and focus on training leaders for hospital, regional, and national groups to reconfigure neurosurgery. Collaboration, flexibility, and leadership will be characteristic of the academic neurosurgeon in this new era.
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Data Sharing: Convert Challenges into Opportunities
Directory of Open Access Journals (Sweden)
Ana Sofia Figueiredo
2017-12-01
Full Text Available Initiatives for sharing research data are opportunities to increase the pace of knowledge discovery and scientific progress. The reuse of research data has the potential to avoid the duplication of data sets and to bring new views from multiple analysis of the same data set. For example, the study of genomic variations associated with cancer profits from the universal collection of such data and helps in selecting the most appropriate therapy for a specific patient. However, data sharing poses challenges to the scientific community. These challenges are of ethical, cultural, legal, financial, or technical nature. This article reviews the impact that data sharing has in science and society and presents guidelines to improve the efficient sharing of research data.
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Scientific collaboration and collective knowledge new essays
Mayo-Wilson, Conor; Weisberg, Michael
2018-01-01
Descartes once argued that, with sufficient effort and skill, a single scientist could uncover fundamental truths about our world. Contemporary science proves the limits of this claim. From synthesizing the human genome to predicting the effects of climate change, some current scientific research requires the collaboration of hundreds (if not thousands) of scientists with various specializations. Additionally, the majority of published scientific research is now co-authored, including more than 80% of articles in the natural sciences, meaning small collaborative teams have become the norm in science. This volume is the first to address critical philosophical questions regarding how collective scientific research could be organized differently and how it should be organized. For example, should scientists be required to share knowledge with competing research teams? How can universities and grant-giving institutions promote successful collaborations? When hundreds of researchers contribute to a discovery, how ...
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African Scientific Network: A model to enhance scientific research in developing countries
Kebede, Abebe
2002-03-01
Africa has over 350 higher education institutions with a variety of experiences and priorities. The primary objectives of these institutions are to produce white-collar workers, teachers, and the work force for mining, textiles, and agricultural industries. The state of higher education and scientific research in Africa have been discussed in several conferences. The proposals that are generated by these conferences advocate structural changes in higher education, North-South institutional linkages, mobilization of the African Diaspora and funding. We propose a model African Scientific Network that would facilitate and enhance international scientific partnerships between African scientists and their counterparts elsewhere. A recent article by James Lamout (Financial Times, August 2, 2001) indicates that emigration from South Africa alone costs $8.9 billion in lost human resources. The article also stated that every year 23,000 graduates leave Africa for opportunities overseas, mainly in Europe, leaving only 20,000 scientists and engineers serving over 600 million people. The International Organization for Migration states that the brain drain of highly skilled professionals from Africa is making economic growth and poverty alleviation impossible across the continent. In our model we will focus on a possible networking mechanism where the African Diaspora will play a major role in addressing the financial and human resources needs of higher education in Africa
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Addressing challenges of modulation transfer function measurement with fisheye lens cameras
Deegan, Brian M.; Denny, Patrick E.; Zlokolica, Vladimir; Dever, Barry; Russell, Laura
2015-03-01
Modulation transfer function (MTF) is a well defined and accepted method of measuring image sharpness. The slanted edge test, as defined in ISO12233 is a standard method of calculating MTF, and is widely used for lens alignment and auto-focus algorithm verification. However, there are a number of challenges which should be considered when measuring MTF in cameras with fisheye lenses. Due to trade-offs related Petzval curvature, planarity of the optical plane is difficult to achieve in fisheye lenses. It is therefore critical to have the ability to accurately measure sharpness throughout the entire image, particularly for lens alignment. One challenge for fisheye lenses is that, because of the radial distortion, the slanted edges will have different angles, depending on the location within the image and on the distortion profile of the lens. Previous work in the literature indicates that MTF measurements are robust for angles between 2 and 10 degrees. Outside of this range, MTF measurements become unreliable. Also, the slanted edge itself will be curved by the lens distortion, causing further measurement problems. This study summarises the difficulties in the use of MTF for sharpness measurement in fisheye lens cameras, and proposes mitigations and alternative methods.
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Challenges of Sustainable and Commercial Aquaponics
Simon Goddek; Boris Delaide; Utra Mankasingh; Kristin Vala Ragnarsdottir; Haissam Jijakli; Ragnheidur Thorarinsdottir
2015-01-01
The world is facing a number of serious problems of which population rise, climate change, soil degradation, water scarcity and food security are among the most important. Aquaponics, as a closed loop system consisting of hydroponics and aquaculture elements, could contribute to addressing these problems. However, there is a lack of quantitative research to support the development of economically feasible aquaponics systems. Although many studies have addressed some scientific aspects, there ...
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Givan, A. V.
2009-12-01
Science is supposed to be about talent devoid of the bias’ and judgments generated by background, gender, ethnicity or any culturally determined discriminators. The scientific, academic, corporate and government communities have a vested interest in developing models, practices and policies that significantly increase the number of U.S. graduates in scientific disciplines. Additionally, it is crucial that these graduates possess the essential competencies and creative problem solving skills to compete in the current global economy. The stakeholders (corporations, researchers, educational practitioners, policymakers and funders) who have the common goal of producing highly qualified scientists must commit to collaborate in developing innovative strategies and solutions to this complex challenge. Volumes of research data from a variety of sources such the social and cognitive sciences, educational psychology, National Science Foundation and non-profit groups have been and are available for use enabling us to rise to the challenge we have been charged with, and are responsible for the outcome. A proposed solution to part of the challenge and discussion of the impacts of increasing diversity in science will be discussed in this paper. The paper will address one element of the issue - strategies for the recruitment and retention of under-represented groups in science focusing on the historical and current culture, climate and barriers encountered by minorities as they progress through the educational system and career pathways. The paper will examine the benefits of diversity to the individual and society as a whole.
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The challenges for human factors in knowledge work
DEFF Research Database (Denmark)
Ipsen, Christine; Møller, Niels; Jensen, Per Langaa
2011-01-01
The development towards a service and knowledge intensive economy arise new challenges for ergonomics and human factors. Knowledge on work within mass service production exists, but the challenges within knowledge work have still to be addressed. The focus of this paper is on some of the challeng...... with the demands of the knowledge intensive work when KPI’s are central management tools. Especially handling the balance between high motivation and enthusiasm and burn out will be addressed....
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West Nile Virus workshop: scientific considerations for tissue donors.
Brubaker, Scott A; Robert Rigney, P
2012-08-01
This report contains selected excerpts, presented as a summary, from a public workshop sponsored by the American Association of Tissue Banks (AATB) held to discuss West Nile Virus (WNV) and scientific considerations for tissue donors. The daylong workshop was held 9 July 2010 at the Ritz-Carlton Hotel at Tyson's Corner in McLean, Virginia, United States (U.S.). The workshop was designed to determine and discuss scientific information that is known, and what is not known, regarding WNV infection and transmission. The goal is to determine how to fill gaps in knowledge of WNV and tissue donation and transplantation by pursuing relevant scientific studies. This information should ultimately support decisions leading to appropriate tissue donor screening and testing considerations. Discussion topics were related to identifying these gaps and determining possible solutions. Workshop participants included subject-matter experts from the U.S. Food and Drug Administration, the Centers for Disease Control and Prevention, U.S. Department of Health and Human Services, Health Canada, the Public Health Agency of Canada, AATB-accredited tissue banks including reproductive tissue banks, accredited eye banks of the Eye Bank Association of America, testing laboratories, and infectious disease and organ transplantation professionals. After all presentations concluded, a panel addressed this question: "What are the scientific considerations for tissue donors and what research could be performed to address those considerations?" The slide presentations from the workshop are available at: http://www.aatb.org/2010-West-Nile-Virus-Workshop-Presentations.
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Fadhil, Ahmed
2018-01-01
Poor nutrition can lead to reduced immunity, increased susceptibility to disease, impaired physical and mental development, and reduced productivity. A conversational agent can support people as a virtual coach, however building such systems still have its associated challenges and limitations. This paper describes the background and motivation for chatbot systems in the context of healthy nutrition recommendation. We discuss current challenges associated with chatbot application, we tackled ...
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Next-generation sequencing for endocrine cancers: Recent advances and challenges.
Suresh, Padmanaban S; Venkatesh, Thejaswini; Tsutsumi, Rie; Shetty, Abhishek
2017-05-01
Contemporary molecular biology research tools have enriched numerous areas of biomedical research that address challenging diseases, including endocrine cancers (pituitary, thyroid, parathyroid, adrenal, testicular, ovarian, and neuroendocrine cancers). These tools have placed several intriguing clues before the scientific community. Endocrine cancers pose a major challenge in health care and research despite considerable attempts by researchers to understand their etiology. Microarray analyses have provided gene signatures from many cells, tissues, and organs that can differentiate healthy states from diseased ones, and even show patterns that correlate with stages of a disease. Microarray data can also elucidate the responses of endocrine tumors to therapeutic treatments. The rapid progress in next-generation sequencing methods has overcome many of the initial challenges of these technologies, and their advantages over microarray techniques have enabled them to emerge as valuable aids for clinical research applications (prognosis, identification of drug targets, etc.). A comprehensive review describing the recent advances in next-generation sequencing methods and their application in the evaluation of endocrine and endocrine-related cancers is lacking. The main purpose of this review is to illustrate the concepts that collectively constitute our current view of the possibilities offered by next-generation sequencing technological platforms, challenges to relevant applications, and perspectives on the future of clinical genetic testing of patients with endocrine tumors. We focus on recent discoveries in the use of next-generation sequencing methods for clinical diagnosis of endocrine tumors in patients and conclude with a discussion on persisting challenges and future objectives.
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Gegner, Julie A.; Mackay, Donald H. J.; Mayer, Richard E.
2009-01-01
High school students can access original scientific research articles on the Internet, but may have trouble understanding them. To address this problem of online literacy, the authors developed a computer-based prototype for guiding students' comprehension of scientific articles. High school students were asked to read an original scientific…
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Slob, A.; Rijnveld, M.
2007-01-01
The EU Project AquaTerra generates knowledge about the river-soil-sediment-groundwater system and delivers scientific information of value for river basin management. In this article, the use and ignorance of scientific knowledge in decision making is explored by a theoretical review. We elaborate
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Ecosystem services provided by a complex coastal region: challenges of classification and mapping
Sousa, Lisa P.; Sousa, Ana I.; Alves, Fátima L.; Lillebø, Ana I.
2016-03-01
A variety of ecosystem services classification systems and mapping approaches are available in the scientific and technical literature, which needs to be selected and adapted when applied to complex territories (e.g. in the interface between water and land, estuary and sea). This paper provides a framework for addressing ecosystem services in complex coastal regions. The roadmap comprises the definition of the exact geographic boundaries of the study area; the use of CICES (Common International Classification of Ecosystem Services) for ecosystem services identification and classification; and the definition of qualitative indicators that will serve as basis to map the ecosystem services. Due to its complexity, the Ria de Aveiro coastal region was selected as case study, presenting an opportunity to explore the application of such approaches at a regional scale. The main challenges of implementing the proposed roadmap, together with its advantages are discussed in this research. The results highlight the importance of considering both the connectivity of natural systems and the complexity of the governance framework; the flexibility and robustness, but also the challenges when applying CICES at regional scale; and the challenges regarding ecosystem services mapping.
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Ecosystem services provided by a complex coastal region: challenges of classification and mapping.
Sousa, Lisa P; Sousa, Ana I; Alves, Fátima L; Lillebø, Ana I
2016-03-11
A variety of ecosystem services classification systems and mapping approaches are available in the scientific and technical literature, which needs to be selected and adapted when applied to complex territories (e.g. in the interface between water and land, estuary and sea). This paper provides a framework for addressing ecosystem services in complex coastal regions. The roadmap comprises the definition of the exact geographic boundaries of the study area; the use of CICES (Common International Classification of Ecosystem Services) for ecosystem services identification and classification; and the definition of qualitative indicators that will serve as basis to map the ecosystem services. Due to its complexity, the Ria de Aveiro coastal region was selected as case study, presenting an opportunity to explore the application of such approaches at a regional scale. The main challenges of implementing the proposed roadmap, together with its advantages are discussed in this research. The results highlight the importance of considering both the connectivity of natural systems and the complexity of the governance framework; the flexibility and robustness, but also the challenges when applying CICES at regional scale; and the challenges regarding ecosystem services mapping.
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Development of advanced nuclear fuels in the Indian context: advantages and challenges
International Nuclear Information System (INIS)
Ganesan, V.
2012-01-01
The ever increasing demand on power requirement in the country has opened up need for exploring use of nuclear fuels that could meet such demands. This makes the mission of the department to shift from the first stage of nuclear programme employing natural uranium in PHWRs to the second stage of deploying a large number of fast reactors with plutonium based fuels capable of realising high breeding ratios in addition to energy production. The transition to fast reactors with advanced fuels, capable of higher breeding ratio, opens up a number of scientific and technological challenges in design and operation of such fast reactors. In the Indian context, after successful demonstration of natural uranium based PHWRs, the performance of U-Pu based carbide fuel, as a unique experience in the world, has been demonstrated in FBTR at Kalpakkam. This paper deals with the performance of carbide fuel in FBTR and the programme on development of metallic fuels with appreciably high breeding ratio that would result in considerable reduction in doubling time thereby addressing the increasing demands of power production as well as pave way for introduction of a large number of such fast reactors to provide energy security to the country. The advantages of introduction of metallic fuels as well as the scientific and technological challenges to be faced in doing so and the ongoing efforts towards metallic fuel development are also described in the paper. (author)
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International Nuclear Information System (INIS)
Wellman, Dawn M.; Freshley, Mark D.; Truex, Michael J.; Lee, M. Hope
2013-01-01
Current requirements for site remediation and closure are standards-based and are often overly conservative, costly, and in some cases, technically impractical to achieve. Use of risk-informed alternate endpoints provide a means to achieve remediation goals that are permitted by regulations and are protective of human health and the environment. Alternate endpoints enable establishing a path for cleanup that may include intermediate remedial milestones and transition points and/or regulatory alternatives to standards-based remediation. A framework is presented that is centered around developing and refining conceptual models in conjunction with assessing risks and potential endpoints as part of a system-based assessment that integrates site data with scientific understanding of processes that control the distribution and transport of contaminants in the subsurface and pathways to receptors. This system-based assessment and subsequent implementation of the remediation strategy with appropriate monitoring are targeted at providing a holistic approach to addressing risks to human health and the environment. This holistic approach also enables effective predictive analysis of contaminant behavior to provide defensible criteria and data for making long-term decisions. Developing and implementing an alternate endpoint-based approach for remediation and waste site closure presents a number of challenges and opportunities. Categories of these challenges include scientific and technical, regulatory, institutional, and budget and resource allocation issues. Opportunities exist for developing and implementing systems-based approaches with respect to supportive characterization, monitoring, predictive modeling, and remediation approaches. (authors)
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Energy Technology Data Exchange (ETDEWEB)
Wellman, Dawn M.; Freshley, Mark D.; Truex, Michael J.; Lee, M. Hope [Pacific Northwest National Laboratory, 902 Battelle Blvd, Richland, WA, 99352 (United States)
2013-07-01
Current requirements for site remediation and closure are standards-based and are often overly conservative, costly, and in some cases, technically impractical to achieve. Use of risk-informed alternate endpoints provide a means to achieve remediation goals that are permitted by regulations and are protective of human health and the environment. Alternate endpoints enable establishing a path for cleanup that may include intermediate remedial milestones and transition points and/or regulatory alternatives to standards-based remediation. A framework is presented that is centered around developing and refining conceptual models in conjunction with assessing risks and potential endpoints as part of a system-based assessment that integrates site data with scientific understanding of processes that control the distribution and transport of contaminants in the subsurface and pathways to receptors. This system-based assessment and subsequent implementation of the remediation strategy with appropriate monitoring are targeted at providing a holistic approach to addressing risks to human health and the environment. This holistic approach also enables effective predictive analysis of contaminant behavior to provide defensible criteria and data for making long-term decisions. Developing and implementing an alternate endpoint-based approach for remediation and waste site closure presents a number of challenges and opportunities. Categories of these challenges include scientific and technical, regulatory, institutional, and budget and resource allocation issues. Opportunities exist for developing and implementing systems-based approaches with respect to supportive characterization, monitoring, predictive modeling, and remediation approaches. (authors)