WorldWideScience

Sample records for adaptive life simulator

  1. Adaptive life simulator: A novel approach to modeling the cardiovascular system

    Energy Technology Data Exchange (ETDEWEB)

    Kangas, L.J.; Keller, P.E.; Hashem, S. [and others

    1995-06-01

    In this paper, an adaptive life simulator (ALS) is introduced. The ALS models a subset of the dynamics of the cardiovascular behavior of an individual by using a recurrent artificial neural network. These models are developed for use in applications that require simulations of cardiovascular systems, such as medical mannequins, and in medical diagnostic systems. This approach is unique in that each cardiovascular model is developed from physiological measurements of an individual. Any differences between the modeled variables and the actual variables of an individual can subsequently be used for diagnosis. This approach also exploits sensor fusion applied to biomedical sensors. Sensor fusion optimizes the utilization of the sensors. The advantage of sensor fusion has been demonstrated in applications including control and diagnostics of mechanical and chemical processes.

  2. Adaptive Sampling in Hierarchical Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Knap, J; Barton, N R; Hornung, R D; Arsenlis, A; Becker, R; Jefferson, D R

    2007-07-09

    We propose an adaptive sampling methodology for hierarchical multi-scale simulation. The method utilizes a moving kriging interpolation to significantly reduce the number of evaluations of finer-scale response functions to provide essential constitutive information to a coarser-scale simulation model. The underlying interpolation scheme is unstructured and adaptive to handle the transient nature of a simulation. To handle the dynamic construction and searching of a potentially large set of finer-scale response data, we employ a dynamic metric tree database. We study the performance of our adaptive sampling methodology for a two-level multi-scale model involving a coarse-scale finite element simulation and a finer-scale crystal plasticity based constitutive law.

  3. Life history adaptations to seasonality

    OpenAIRE

    Varpe, Øystein Heggernes

    2007-01-01

    The thesis contains studies of animal life histories at high latitudes. Several topics are covered; from ecosystem consequences of life histories to tests of specific behavioural predictions put forward based on life history arguments. Work on complete life histories is also included in an attempt to understand the evolution of capital and income breeding in marine copepods. My main research questions, followed by main topics and findings, are as follows: • How are seasonal ...

  4. Time Simulation of Bone Adaptation

    DEFF Research Database (Denmark)

    Bagge, Mette

    1998-01-01

    The structural adaptation of a three-dimensional finite element model ofthe proximal femur is considered. Presuming the bone possesses the optimalstructure under the given loads, the bone material distribution is foundby minimizing the strain energy averaged over ten load cases with avolume...... constraint. Theoptimized design is used as a start-configuration for the remodelingsimulation.The parameter characterizing the equilibrium level where no remodeling occurs is estimated from the optimization parameters.The loads vary in magnitude, location and direction simulating timedependent loading. The...

  5. The Adaptive Multi-scale Simulation Infrastructure

    Energy Technology Data Exchange (ETDEWEB)

    Tobin, William R. [Rensselaer Polytechnic Inst., Troy, NY (United States)

    2015-09-01

    The Adaptive Multi-scale Simulation Infrastructure (AMSI) is a set of libraries and tools developed to support the development, implementation, and execution of general multimodel simulations. Using a minimal set of simulation meta-data AMSI allows for minimally intrusive work to adapt existent single-scale simulations for use in multi-scale simulations. Support for dynamic runtime operations such as single- and multi-scale adaptive properties is a key focus of AMSI. Particular focus has been spent on the development on scale-sensitive load balancing operations to allow single-scale simulations incorporated into a multi-scale simulation using AMSI to use standard load-balancing operations without affecting the integrity of the overall multi-scale simulation.

  6. Electronic Quality of Life Assessment Using Computer-Adaptive Testing

    Science.gov (United States)

    2016-01-01

    Background Quality of life (QoL) questionnaires are desirable for clinical practice but can be time-consuming to administer and interpret, making their widespread adoption difficult. Objective Our aim was to assess the performance of the World Health Organization Quality of Life (WHOQOL)-100 questionnaire as four item banks to facilitate adaptive testing using simulated computer adaptive tests (CATs) for physical, psychological, social, and environmental QoL. Methods We used data from the UK WHOQOL-100 questionnaire (N=320) to calibrate item banks using item response theory, which included psychometric assessments of differential item functioning, local dependency, unidimensionality, and reliability. We simulated CATs to assess the number of items administered before prespecified levels of reliability was met. Results The item banks (40 items) all displayed good model fit (P>.01) and were unidimensional (fewer than 5% of t tests significant), reliable (Person Separation Index>.70), and free from differential item functioning (no significant analysis of variance interaction) or local dependency (residual correlations banks were between 45% and 75% shorter than paper-based WHOQOL measures. Across the four domains, a high standard of reliability (alpha>.90) could be gained with a median of 9 items. Conclusions Using CAT, simulated assessments were as reliable as paper-based forms of the WHOQOL with a fraction of the number of items. These properties suggest that these item banks are suitable for computerized adaptive assessment. These item banks have the potential for international development using existing alternative language versions of the WHOQOL items. PMID:27694100

  7. Adaptive Multilevel Monte Carlo Simulation

    KAUST Repository

    Hoel, H

    2011-08-23

    This work generalizes a multilevel forward Euler Monte Carlo method introduced in Michael B. Giles. (Michael Giles. Oper. Res. 56(3):607–617, 2008.) for the approximation of expected values depending on the solution to an Itô stochastic differential equation. The work (Michael Giles. Oper. Res. 56(3):607– 617, 2008.) proposed and analyzed a forward Euler multilevelMonte Carlo method based on a hierarchy of uniform time discretizations and control variates to reduce the computational effort required by a standard, single level, Forward Euler Monte Carlo method. This work introduces an adaptive hierarchy of non uniform time discretizations, generated by an adaptive algorithmintroduced in (AnnaDzougoutov et al. Raùl Tempone. Adaptive Monte Carlo algorithms for stopped diffusion. In Multiscale methods in science and engineering, volume 44 of Lect. Notes Comput. Sci. Eng., pages 59–88. Springer, Berlin, 2005; Kyoung-Sook Moon et al. Stoch. Anal. Appl. 23(3):511–558, 2005; Kyoung-Sook Moon et al. An adaptive algorithm for ordinary, stochastic and partial differential equations. In Recent advances in adaptive computation, volume 383 of Contemp. Math., pages 325–343. Amer. Math. Soc., Providence, RI, 2005.). This form of the adaptive algorithm generates stochastic, path dependent, time steps and is based on a posteriori error expansions first developed in (Anders Szepessy et al. Comm. Pure Appl. Math. 54(10):1169– 1214, 2001). Our numerical results for a stopped diffusion problem, exhibit savings in the computational cost to achieve an accuracy of ϑ(TOL),from(TOL−3), from using a single level version of the adaptive algorithm to ϑ(((TOL−1)log(TOL))2).

  8. Lamarck and the adaptive conservation of life

    Directory of Open Access Journals (Sweden)

    Galera, Andrés

    2009-12-01

    Full Text Available This paper studies Lamarck’s evolutionary thought through four analytic elements. Firstly, Lamarckian construction of a founding evolutionary archetype. Secondly, the interpretation of nature as a material system where the organic change represents a continuous process aimed at the adaptative conservation of life. Thirdly, the definition of a genealogical process on the origin of species which identifies the natural method. Fourthly, the redefinition of the concept of species applying the arguments of temporary relativity and individual instability.

    En este artículo se estudia el ideario evolucionista lamarckiano desarrollando cuatro elementos analíticos. Primero, la elaboración de un arquetipo evolutivo fundacional. Segundo, la interpretación de la naturaleza como un sistema material donde el cambio orgánico da sentido a un proceso continuo dirigido a la conservación de la vida. Tercero, la definición de un principio genealógico sobre el origen de las especies que identifica el método natural. Cuarto, la reformulación del concepto de especie utilizando los argumentos de relatividad temporal e inestabilidad individual.

  9. Adaptive simulated annealing (ASA): Lessons learned

    OpenAIRE

    Ingber, L.

    2000-01-01

    Adaptive simulated annealing (ASA) is a global optimization algorithm based on an associated proof that the parameter space can be sampled much more efficiently than by using other previous simulated annealing algorithms. The author's ASA code has been publicly available for over two years. During this time the author has volunteered to help people via e-mail, and the feedback obtained has been used to further develop the code. Some lessons learned, in particular some which are relevant to ot...

  10. Adaptability and Life Satisfaction: The Moderating Role of Social Support

    Science.gov (United States)

    Zhou, Mi; Lin, Weipeng

    2016-01-01

    The purpose of this study was to investigate the moderating role of social support in the relationship between adaptability and life satisfaction. Data were collected from 99 undergraduate freshmen in a Chinese university using a lagged design with a 1-month interval. Results demonstrated that social support moderated the relation between adaptability and life satisfaction, such that the positive relation between adaptability and life satisfaction was stronger for individuals with higher levels of social support than for individuals with lower levels of social support. The theoretical and practical implications of this result are discussed. PMID:27516753

  11. Friendship and adaption across the life span

    NARCIS (Netherlands)

    Hartup, W.W.; Stevens, N.L.

    1999-01-01

    Friends foster self-esteem and a sense of well-being, socialize one another, and support one another in coping with developmental transitions and life stress. Friends engage in different activities with one another across the life span, but friendship is conceived similarly by children and adults. F

  12. Adaptive wavelet simulation of global ocean dynamics

    Directory of Open Access Journals (Sweden)

    N. K.-R. Kevlahan

    2015-07-01

    Full Text Available In order to easily enforce solid-wall boundary conditions in the presence of complex coastlines, we propose a new mass and energy conserving Brinkman penalization for the rotating shallow water equations. This penalization does not lead to higher wave speeds in the solid region. The error estimates for the penalization are derived analytically and verified numerically for linearized one dimensional equations. The penalization is implemented in a conservative dynamically adaptive wavelet method for the rotating shallow water equations on the sphere with bathymetry and coastline data from NOAA's ETOPO1 database. This code could form the dynamical core for a future global ocean model. The potential of the dynamically adaptive ocean model is illustrated by using it to simulate the 2004 Indonesian tsunami and wind-driven gyres.

  13. Mandela's Meanings: A Translated and Adapted Life

    OpenAIRE

    Carli Coetzee

    2014-01-01

    This paper reflects on the seeming ubiquity of representations of Nelson Mandela, and contrasts this with the years of silence and facelessness that have entered the mythological sphere - the 18 years he spent on Robben Island. The period when Mandela (through text or image) circulated the least has now in fact become the centrepiece of the narrative of his life. In this paper, I reconstitute some of the literary and photographic fragments of that era, one for which the biographical record is...

  14. Adaptive Resolution Simulation in Equilibrium and Beyond

    CERN Document Server

    Wang, Han

    2014-01-01

    In this paper, we investigate the equilibrium statistical properties of both the force and potential interpolations of adaptive resolution simulation (AdResS) under the theoretical framework of grand-canonical like AdResS (GC-AdResS). The thermodynamic relations between the higher and lower resolutions are derived by considering the absence of fundamental conservation laws in mechanics for both branches of AdResS. In order to investigate the applicability of AdResS method in studying the properties beyond the equilibrium, we demonstrate the accuracy of AdResS in computing the dynamical properties in two numerical examples: The velocity auto-correlation of pure water and the conformational relaxation of alanine dipeptide dissolved in water. Theoretical and technical open questions of the AdResS method are discussed in the end of the paper.

  15. Simulation of Biochemical Pathway Adaptability Using Evolutionary Algorithms

    Energy Technology Data Exchange (ETDEWEB)

    Bosl, W J

    2005-01-26

    The systems approach to genomics seeks quantitative and predictive descriptions of cells and organisms. However, both the theoretical and experimental methods necessary for such studies still need to be developed. We are far from understanding even the simplest collective behavior of biomolecules, cells or organisms. A key aspect to all biological problems, including environmental microbiology, evolution of infectious diseases, and the adaptation of cancer cells is the evolvability of genomes. This is particularly important for Genomes to Life missions, which tend to focus on the prospect of engineering microorganisms to achieve desired goals in environmental remediation and climate change mitigation, and energy production. All of these will require quantitative tools for understanding the evolvability of organisms. Laboratory biodefense goals will need quantitative tools for predicting complicated host-pathogen interactions and finding counter-measures. In this project, we seek to develop methods to simulate how external and internal signals cause the genetic apparatus to adapt and organize to produce complex biochemical systems to achieve survival. This project is specifically directed toward building a computational methodology for simulating the adaptability of genomes. This project investigated the feasibility of using a novel quantitative approach to studying the adaptability of genomes and biochemical pathways. This effort was intended to be the preliminary part of a larger, long-term effort between key leaders in computational and systems biology at Harvard University and LLNL, with Dr. Bosl as the lead PI. Scientific goals for the long-term project include the development and testing of new hypotheses to explain the observed adaptability of yeast biochemical pathways when the myosin-II gene is deleted and the development of a novel data-driven evolutionary computation as a way to connect exploratory computational simulation with hypothesis

  16. Gender and adaptation to widowhood in later life

    NARCIS (Netherlands)

    Stevens, N.L.

    1995-01-01

    Examination of the well-being and living conditions of older widows and widowers reveals ways in which adaptation to loss of the partner in later life is influenced by gender. This article compares the results of two Dutch studies, one on men and one on women between the ages of 60 and 75, living in

  17. Using Site Testing Data for Adaptive Optics Simulations

    OpenAIRE

    Herriot, Glen; Andersen, David; Conan, Rod; Ellerbroek, Brent; Gilles, Luc; Hickson, Paul; Jackson, Kate; Lardière, Olivier; Pfrommer, Thomas; Véran, Jean-Pierre; Wang, Lianqi

    2011-01-01

    Astronomical Site testing data plays a vital role in the simulation, design, evaluation and operation of adaptive optics systems for large telescope. We present the example of TMT and its first light facilitiy adaptive optics system NFIRAOS, and illustrate the many simulations done based on site testing data.

  18. Exploring the Use of Adaptively Restrained Particles for Graphics Simulations

    OpenAIRE

    Pierre-Luc Manteaux; Fran\\xe7ois Faure; Stephane Redon; Marie-Paule Cani

    2013-01-01

    International audience In this paper, we explore the use of Adaptively Restrained (AR) particles for graphics simulations. Contrary to previous methods, Adaptively Restrained Particle Simulations (ARPS) do not adapt time or space sampling, but rather switch the positional degrees of freedom of particles on and off, while letting their momenta evolve. Therefore, inter-particles forces do not have to be updated at each time step, in contrast with traditional methods that spend a lot of time ...

  19. [Real life simulations to train nurses].

    Science.gov (United States)

    Alonso Felpete, Alberto Jesús; Abajas Bustillo, Rebeca; De la Horra Gutiérrez, Inmaculada; Hoz Cuerno, Verónica; Llata Agüero, Gema; López López, Luis Mariano; Sánchez Herrán, Beatriz

    2004-01-01

    Nurses must confront critical potential life threatening situations daily. These are very tense situations which must be solved in a rapid, adequate manner in coordination with the rest of the professional health team. How to deal with these crises, which usually follow an established protocol, must be learned and practiced in a safe environment which provides the greatest possible guarantee of success. The best way to acquire this knowledge and skill is through a real life simulation. Nurses from various disciplines carry out their work in the Training Center for Critical Crises at the Marqués de Valdecilla University Hospital in Santander, the only center in Spain which runs this type of simulation. In 2003, this center initiated a specific training simulation for nurses whose purpose is to increase scientific-technical knowledge to the maximum and accelerate the learning of non-technical social and cognitive fundamentals within the working environment of a professional health team. The following article describes a simulation meeting these characteristics, its teaching methods, advantages, importance for professional health teams, and its repercussions on patients.

  20. Self-adaptive genetic algorithms with simulated binary crossover.

    Science.gov (United States)

    Deb, K; Beyer, H G

    2001-01-01

    Self-adaptation is an essential feature of natural evolution. However, in the context of function optimization, self-adaptation features of evolutionary search algorithms have been explored mainly with evolution strategy (ES) and evolutionary programming (EP). In this paper, we demonstrate the self-adaptive feature of real-parameter genetic algorithms (GAs) using a simulated binary crossover (SBX) operator and without any mutation operator. The connection between the working of self-adaptive ESs and real-parameter GAs with the SBX operator is also discussed. Thereafter, the self-adaptive behavior of real-parameter GAs is demonstrated on a number of test problems commonly used in the ES literature. The remarkable similarity in the working principle of real-parameter GAs and self-adaptive ESs shown in this study suggests the need for emphasizing further studies on self-adaptive GAs. PMID:11382356

  1. ADAPTIVE CHARACTERISTICS OF HERONS PLUMAGE FOR THEIR WAY OF LIFE

    Directory of Open Access Journals (Sweden)

    Koshelev V. A.

    2011-12-01

    Full Text Available Feather cover of each bird species reflects spectra of species, age, sex and environmental attributes defined the phylogeny of taxa, habitat and life patterns. In turn, many ecological phenomena in the birds’ life patterns are directly dependent on the state of plumage (e.g., time of breeding, seasonal migration, roost flights. For the first time the quantitative characterization of six heron species' plumage were done as well as the description of powder down feathers. The adaptive features of feathers and various types of heron’s plumages were discussed.The structure of contour feathers of herons is related to the peculiarities of species life pattern. All the species have a relatively small number of contour feathers, despite their large body size. According to this index the herons are more similar to typical wading birds (gulls, sandpipers than for waterfowl. The total number of heron feathers slightly increase in winter, because they are migratory species. Structure of contour feathers of herons corresponds to that of other waterbirds. The rod is not bent, the feathers are large, and the mounting angle to the surface of the body is little. The cores of abdominal feather fracts reduce heat transfer and can be regarded as an adaptation factor to aquatic environment.Buoyancy is provided by heron’s feathers insignificantly, in contrast to the typical waterfowl species. Significant subcutaneous fat stores are typical for herons in spring, autumn and winter, increased buoyancy and being the energy reserves provide thermoregulation in cold environment. Our data indicate weak adaptation of herons’ plumage to aquatic environments, but also confirm its insulating properties, which is prove the herons semi-aquatic rather than aquatic life patterns.Due to color of plumage some three groups of herons were considered: white, mottled and camouflaged. Coloration of second and third group performs a protective function. We didn’t found a clear

  2. The brine shrimp Artemia: adapted to critical life conditions

    Directory of Open Access Journals (Sweden)

    Gonzalo M Gajardo

    2012-06-01

    Full Text Available The brine shrimp Artemia is a micro-crustacean, well adapted to the harsh conditions that severely hypersaline environments impose on survival and reproduction. Adaptation to these conditions has taken place at different functional levels or domains, from the individual (molecular-cellular-physiological to the population level. Such conditions are experienced by very few equivalent macro-planktonic organisms; thus, Artemia can be considered a model animal extremophile offering a unique suite of adaptations that are the focus of this review. The most obvious is a highly efficient osmoregulation system to withstand up to 10 times the salt concentration of ordinary seawater. Under extremely critical environmental conditions, for example when seasonal lakes dry out, Artemia takes refuge by producing a highly resistant encysted gastrula embryo (cyst capable of severe dehydration enabling an escape from population extinction. Cysts can be viewed as gene banks that store a genetic memory of historical population conditions. Their occurrence is due to the evolved ability of females to perceive forthcoming unstable environmental conditions expressed by their ability to switch reproductive mode, producing either cysts (oviparity when environmental conditions become deleterious or free-swimming nauplii (ovoviviparity that are able to maintain the population under suitable conditions.At the population level the trend is for conspecific populations to be fragmented into locally adapted populations, whereas species are restricted to salty lakes in particular regions (regional endemism. The Artemia model depicts adaptation as a complex response to critical life conditions, integrating and refining past and present experiences at all levels of organization. Although we consider an invertebrate restricted to a unique environment, the processes to be discussed are of general biological interest. Finally, we highlight the benefits of understanding the stress

  3. Adaptive kernel methods to simulate quantum phase space flow

    Directory of Open Access Journals (Sweden)

    H.López

    2006-01-01

    Full Text Available A technique for simulating quantum dynamics in phase space is discussed. It makes use of ensembles of classical trajectories to approximate the distribution functions and their derivatives by implementing Adaptive Kernel Density Estimation. It is found to improve the accuracy and stability of the simulations compared to more conventional particle methods. Formulation of the method in higher dimensions is straightforward.

  4. Simulation and Rapid Prototyping of Adaptive Control Systems using the Adaptive Blockset for Simulink

    DEFF Research Database (Denmark)

    Ravn, Ole

    1998-01-01

    The paper describes the design considerations and implementational aspects of the Adaptive Blockset for Simulink which has been developed in a prototype implementation. The concept behind the Adaptive Blockset for Simulink is to bridge the gap between simulation and prototype controller...... implementation. This is done using the code generation capabilities of Real Time Workshop in combination with C s-function blocks for adaptive control in Simulink. In the paper the design of each group of blocks normally found in adaptive controllers is outlined. The block types are, identification, controller...... design, controller and state variable filter.The use of the Adaptive Blockset is demonstrated using a simple laboratory setup. Both the use of the blockset for simulation and for rapid prototyping of a real-time controller are shown....

  5. Adaptive LES Methodology for Turbulent Flow Simulations

    Energy Technology Data Exchange (ETDEWEB)

    Oleg V. Vasilyev

    2008-06-12

    Although turbulent flows are common in the world around us, a solution to the fundamental equations that govern turbulence still eludes the scientific community. Turbulence has often been called one of the last unsolved problem in classical physics, yet it is clear that the need to accurately predict the effect of turbulent flows impacts virtually every field of science and engineering. As an example, a critical step in making modern computational tools useful in designing aircraft is to be able to accurately predict the lift, drag, and other aerodynamic characteristics in numerical simulations in a reasonable amount of time. Simulations that take months to years to complete are much less useful to the design cycle. Much work has been done toward this goal (Lee-Rausch et al. 2003, Jameson 2003) and as cost effective accurate tools for simulating turbulent flows evolve, we will all benefit from new scientific and engineering breakthroughs. The problem of simulating high Reynolds number (Re) turbulent flows of engineering and scientific interest would have been solved with the advent of Direct Numerical Simulation (DNS) techniques if unlimited computing power, memory, and time could be applied to each particular problem. Yet, given the current and near future computational resources that exist and a reasonable limit on the amount of time an engineer or scientist can wait for a result, the DNS technique will not be useful for more than 'unit' problems for the foreseeable future (Moin & Kim 1997, Jimenez & Moin 1991). The high computational cost for the DNS of three dimensional turbulent flows results from the fact that they have eddies of significant energy in a range of scales from the characteristic length scale of the flow all the way down to the Kolmogorov length scale. The actual cost of doing a three dimensional DNS scales as Re{sup 9/4} due to the large disparity in scales that need to be fully resolved. State-of-the-art DNS calculations of isotropic

  6. PASSATA - Object oriented numerical simulation software for adaptive optics

    CERN Document Server

    Agapito, G; Esposito, S

    2016-01-01

    We present the last version of the PyrAmid Simulator Software for Adaptive opTics Arcetri (PASSATA), an IDL and CUDA based object oriented software developed in the Adaptive Optics group of the Arcetri observatory for Monte-Carlo end-to-end adaptive optics simulations. The original aim of this software was to evaluate the performance of a single conjugate adaptive optics system for ground based telescope with a pyramid wavefront sensor. After some years of development, the current version of PASSATA is able to simulate several adaptive optics systems: single conjugate, multi conjugate and ground layer, with Shack Hartmann and Pyramid wavefront sensors. It can simulate from 8m to 40m class telescopes, with diffraction limited and resolved sources at finite or infinite distance from the pupil. The main advantages of this software are the versatility given by the object oriented approach and the speed given by the CUDA implementation of the most computational demanding routines. We describe the software with its...

  7. A real-time simulation facility for astronomical adaptive optics

    CERN Document Server

    Basden, Alastair

    2014-01-01

    In this paper we introduce the concept of real-time hardware-in-the-loop simulation for astronomical adaptive optics, and present the case for the requirement for such a facility. This real-time simulation, when linked with an adaptive optics real-time control system, provides an essential tool for the validation, verification and integration of the Extremely Large Telescope real-time control systems prior to commissioning at the telescope. We demonstrate that such a facility is crucial for the success of the future extremely large telescopes.

  8. Adaptive Simulated Annealing Based Protein Loop Modeling of Neurotoxins

    Institute of Scientific and Technical Information of China (English)

    陈杰; 黄丽娜; 彭志红

    2003-01-01

    A loop modeling method, adaptive simulated annealing, for ab initio prediction of protein loop structures, as an optimization problem of searching the global minimum of a given energy function, is proposed. An interface-friendly toolbox-LoopModeller in Windows and Linux systems, VC++ and OpenGL environments is developed for analysis and visualization. Simulation results of three short-chain neurotoxins modeled by LoopModeller show that the method proposed is fast and efficient.

  9. Is life-history buffering or lability adaptive in stochastic environments?

    DEFF Research Database (Denmark)

    Koons, David N.; Pavard, Samuel; Baudisch, Annette;

    2009-01-01

    in demographic parameters over time. We detail why this assumption may often break down and why selection should not always favor buffering of demographic parameters against environmental stochasticity. To the contrary, nonlinear relationships between the environment and demographic performance can produce...... asymmetric temporal variation in demographic parameters that actually enhances fitness. We extend this result to structured populations using simulation and show that 'demographic lability' rather than 'buffering' may be adaptive, particularly in organisms with low juvenile or adult survival. Finally, we...... review previous ecological work, and indicate cases where 'demographic lability' may be adaptive, then conclude by identifying research that is needed to develop a theory of life-history evolution that encompasses both demographic buffering and lability. © 2009 Oikos....

  10. SimulCAT: Windows Software for Simulating Computerized Adaptive Test Administration

    Science.gov (United States)

    Han, Kyung T.

    2012-01-01

    Most, if not all, computerized adaptive testing (CAT) programs use simulation techniques to develop and evaluate CAT program administration and operations, but such simulation tools are rarely available to the public. Up to now, several software tools have been available to conduct CAT simulations for research purposes; however, these existing…

  11. The relative entropy is fundamental to adaptive resolution simulations

    Science.gov (United States)

    Kreis, Karsten; Potestio, Raffaello

    2016-07-01

    Adaptive resolution techniques are powerful methods for the efficient simulation of soft matter systems in which they simultaneously employ atomistic and coarse-grained (CG) force fields. In such simulations, two regions with different resolutions are coupled with each other via a hybrid transition region, and particles change their description on the fly when crossing this boundary. Here we show that the relative entropy, which provides a fundamental basis for many approaches in systematic coarse-graining, is also an effective instrument for the understanding of adaptive resolution simulation methodologies. We demonstrate that the use of coarse-grained potentials which minimize the relative entropy with respect to the atomistic system can help achieve a smoother transition between the different regions within the adaptive setup. Furthermore, we derive a quantitative relation between the width of the hybrid region and the seamlessness of the coupling. Our results do not only shed light on the what and how of adaptive resolution techniques but will also help setting up such simulations in an optimal manner.

  12. Adaptive resolution simulation of an atomistic protein in MARTINI water

    NARCIS (Netherlands)

    Zavadlav, Julija; Melo, Manuel Nuno; Marrink, Siewert J.; Praprotnik, Matej

    2014-01-01

    We present an adaptive resolution simulation of protein G in multiscale water. We couple atomistic water around the protein with mesoscopic water, where four water molecules are represented with one coarse-grained bead, farther away. We circumvent the difficulties that arise from coupling to the coa

  13. The behavior of adaptive bone-remodeling simulation models

    NARCIS (Netherlands)

    H.H. Weinans (Harrie); R. Huiskes (Rik); H.J. Grootenboer

    1992-01-01

    textabstractThe process of adaptive bone remodeling can be described mathematically and simulated in a computer model, integrated with the finite element method. In the model discussed here, cortical and trabecular bone are described as continuous materials with variable density. The remodeling rule

  14. Adaptive Sampling Algorithms for Probabilistic Risk Assessment of Nuclear Simulations

    Energy Technology Data Exchange (ETDEWEB)

    Diego Mandelli; Dan Maljovec; Bei Wang; Valerio Pascucci; Peer-Timo Bremer

    2013-09-01

    Nuclear simulations are often computationally expensive, time-consuming, and high-dimensional with respect to the number of input parameters. Thus exploring the space of all possible simulation outcomes is infeasible using finite computing resources. During simulation-based probabilistic risk analysis, it is important to discover the relationship between a potentially large number of input parameters and the output of a simulation using as few simulation trials as possible. This is a typical context for performing adaptive sampling where a few observations are obtained from the simulation, a surrogate model is built to represent the simulation space, and new samples are selected based on the model constructed. The surrogate model is then updated based on the simulation results of the sampled points. In this way, we attempt to gain the most information possible with a small number of carefully selected sampled points, limiting the number of expensive trials needed to understand features of the simulation space. We analyze the specific use case of identifying the limit surface, i.e., the boundaries in the simulation space between system failure and system success. In this study, we explore several techniques for adaptively sampling the parameter space in order to reconstruct the limit surface. We focus on several adaptive sampling schemes. First, we seek to learn a global model of the entire simulation space using prediction models or neighborhood graphs and extract the limit surface as an iso-surface of the global model. Second, we estimate the limit surface by sampling in the neighborhood of the current estimate based on topological segmentations obtained locally. Our techniques draw inspirations from topological structure known as the Morse-Smale complex. We highlight the advantages and disadvantages of using a global prediction model versus local topological view of the simulation space, comparing several different strategies for adaptive sampling in both

  15. Adaptive thinking & leadership simulation game training for special forces officers.

    Energy Technology Data Exchange (ETDEWEB)

    Raybourn, Elaine Marie; Mendini, Kip (USA JFKSWCS DOTD, Ft. Bragg, NC); Heneghan, Jerry; Deagle, Edwin (USA JFKSWCS DOTD, Ft. Bragg, NC)

    2005-07-01

    Complex problem solving approaches and novel strategies employed by the military at the squad, team, and commander level are often best learned experimentally. Since live action exercises can be costly, advances in simulation game training technology offer exciting ways to enhance current training. Computer games provide an environment for active, critical learning. Games open up possibilities for simultaneous learning on multiple levels; players may learn from contextual information embedded in the dynamics of the game, the organic process generated by the game, and through the risks, benefits, costs, outcomes, and rewards of alternative strategies that result from decision making. In the present paper we discuss a multiplayer computer game simulation created for the Adaptive Thinking & Leadership (ATL) Program to train Special Forces Team Leaders. The ATL training simulation consists of a scripted single-player and an immersive multiplayer environment for classroom use which leverages immersive computer game technology. We define adaptive thinking as consisting of competencies such as negotiation and consensus building skills, the ability to communicate effectively, analyze ambiguous situations, be self-aware, think innovatively, and critically use effective problem solving skills. Each of these competencies is an essential element of leader development training for the U.S. Army Special Forces. The ATL simulation is used to augment experiential learning in the curriculum for the U.S. Army JFK Special Warfare Center & School (SWCS) course in Adaptive Thinking & Leadership. The school is incorporating the ATL simulation game into two additional training pipelines (PSYOPS and Civil Affairs Qualification Courses) that are also concerned with developing cultural awareness, interpersonal communication adaptability, and rapport-building skills. In the present paper, we discuss the design, development, and deployment of the training simulation, and emphasize how the

  16. Adaptive deployment of model reductions for tau-leaping simulation.

    Science.gov (United States)

    Wu, Sheng; Fu, Jin; Petzold, Linda R

    2015-05-28

    Multiple time scales in cellular chemical reaction systems often render the tau-leaping algorithm inefficient. Various model reductions have been proposed to accelerate tau-leaping simulations. However, these are often identified and deployed manually, requiring expert knowledge. This is time-consuming and prone to error. In previous work, we proposed a methodology for automatic identification and validation of model reduction opportunities for tau-leaping simulation. Here, we show how the model reductions can be automatically and adaptively deployed during the time course of a simulation. For multiscale systems, this can result in substantial speedups.

  17. Adaptive deployment of model reductions for tau-leaping simulation

    Science.gov (United States)

    Wu, Sheng; Fu, Jin; Petzold, Linda R.

    2015-05-01

    Multiple time scales in cellular chemical reaction systems often render the tau-leaping algorithm inefficient. Various model reductions have been proposed to accelerate tau-leaping simulations. However, these are often identified and deployed manually, requiring expert knowledge. This is time-consuming and prone to error. In previous work, we proposed a methodology for automatic identification and validation of model reduction opportunities for tau-leaping simulation. Here, we show how the model reductions can be automatically and adaptively deployed during the time course of a simulation. For multiscale systems, this can result in substantial speedups.

  18. A First Life with Computerized Business Simulations

    Science.gov (United States)

    Thavikulwat, Precha

    2011-01-01

    The author discusses the theoretical lens, origins, and environment of his work on computerized business simulations. Key ideas that inform his work include the two dimensions (control and interaction) of computerized simulation, the two ways of representing a natural process (phenotypical and genotypical) in a simulation, which he defines as a…

  19. Improving the adaptability of simulated evolutionary swarm robots in dynamically changing environments.

    Directory of Open Access Journals (Sweden)

    Yao Yao

    Full Text Available One of the important challenges in the field of evolutionary robotics is the development of systems that can adapt to a changing environment. However, the ability to adapt to unknown and fluctuating environments is not straightforward. Here, we explore the adaptive potential of simulated swarm robots that contain a genomic encoding of a bio-inspired gene regulatory network (GRN. An artificial genome is combined with a flexible agent-based system, representing the activated part of the regulatory network that transduces environmental cues into phenotypic behaviour. Using an artificial life simulation framework that mimics a dynamically changing environment, we show that separating the static from the conditionally active part of the network contributes to a better adaptive behaviour. Furthermore, in contrast with most hitherto developed ANN-based systems that need to re-optimize their complete controller network from scratch each time they are subjected to novel conditions, our system uses its genome to store GRNs whose performance was optimized under a particular environmental condition for a sufficiently long time. When subjected to a new environment, the previous condition-specific GRN might become inactivated, but remains present. This ability to store 'good behaviour' and to disconnect it from the novel rewiring that is essential under a new condition allows faster re-adaptation if any of the previously observed environmental conditions is reencountered. As we show here, applying these evolutionary-based principles leads to accelerated and improved adaptive evolution in a non-stable environment.

  20. Adaptive image ray-tracing for astrophysical simulations

    CERN Document Server

    Parkin, E R

    2010-01-01

    A technique is presented for producing synthetic images from numerical simulations whereby the image resolution is adapted around prominent features. In so doing, adaptive image ray-tracing (AIR) improves the efficiency of a calculation by focusing computational effort where it is needed most. The results of test calculations show that a factor of >~ 4 speed-up, and a commensurate reduction in the number of pixels required in the final image, can be achieved compared to an equivalent calculation with a fixed resolution image.

  1. Adaptive expertise in work life:implications for collaboration and shared expertise

    OpenAIRE

    Palosaari-Aubry, P. (Päivi)

    2014-01-01

    This study aims at drawing a picture of adaptive expertise in work life, more precisely in the context of collaboration and shared expertise. The need for my study stems from the complex nature of today’s work life, which is under constant change. Thus, mere domain-specific expertise and routine expertise are not sufficient. There is a need for adaptive experts who are flexible, able to adapt to uncertain situations (Bransford, 2004; Hatano & Inagaki, 1986), successful learners and able to de...

  2. Adaptations to polar life in mammals and birds.

    Science.gov (United States)

    Blix, Arnoldus Schytte

    2016-04-15

    This Review presents a broad overview of adaptations of truly Arctic and Antarctic mammals and birds to the challenges of polar life. The polar environment may be characterized by grisly cold, scarcity of food and darkness in winter, and lush conditions and continuous light in summer. Resident animals cope with these changes by behavioural, physical and physiological means. These include responses aimed at reducing exposure, such as 'balling up', huddling and shelter building; seasonal changes in insulation by fur, plumage and blubber; and circulatory adjustments aimed at preservation of core temperature, to which end the periphery and extremities are cooled to increase insulation. Newborn altricial animals have profound tolerance to hypothermia, but depend on parental care for warmth, whereas precocial mammals are well insulated and respond to cold with non-shivering thermogenesis in brown adipose tissue, and precocial birds shiver to produce heat. Most polar animals prepare themselves for shortness of food during winter by the deposition of large amounts of fat in times of plenty during autumn. These deposits are governed by a sliding set-point for body fatness throughout winter so that they last until the sun reappears in spring. Polar animals are, like most others, primarily active during the light part of the day, but when the sun never sets in summer and darkness prevails during winter, high-latitude animals become intermittently active around the clock, allowing opportunistic feeding at all times. The importance of understanding the needs of the individuals of a species to understand the responses of populations in times of climate change is emphasized. PMID:27103673

  3. Disaster Rescue Simulation based on Complex Adaptive Theory

    Directory of Open Access Journals (Sweden)

    Feng Jiang

    2013-05-01

    Full Text Available Disaster rescue is one of the key measures of disaster reduction. The rescue process is a complex process with the characteristics of large scale, complicate structure, non-linear. It is hard to describe and analyze them with traditional methods. Based on complex adaptive theory, this paper analyzes the complex adaptation of the rescue process from seven features: aggregation, nonlinearity, mobility, diversity, tagging, internal model and building block. With the support of Repast platform, an agent-based model including rescue agents and victim agents was proposed. Moreover, two simulations with different parameters are employed to examine the feasibility of the model. As a result, the proposed model has been shown that it is efficient in dealing with the disaster rescue simulation and can provide the reference for making decisions.

  4. Adaptive quantum computation in changing environments using projective simulation

    Science.gov (United States)

    Tiersch, M.; Ganahl, E. J.; Briegel, H. J.

    2015-08-01

    Quantum information processing devices need to be robust and stable against external noise and internal imperfections to ensure correct operation. In a setting of measurement-based quantum computation, we explore how an intelligent agent endowed with a projective simulator can act as controller to adapt measurement directions to an external stray field of unknown magnitude in a fixed direction. We assess the agent’s learning behavior in static and time-varying fields and explore composition strategies in the projective simulator to improve the agent’s performance. We demonstrate the applicability by correcting for stray fields in a measurement-based algorithm for Grover’s search. Thereby, we lay out a path for adaptive controllers based on intelligent agents for quantum information tasks.

  5. Nonlinear Adaptive Robust Force Control of Hydraulic Load Simulator

    Institute of Scientific and Technical Information of China (English)

    YAO Jianyong; JIAO Zongxia; YAO Bin; SHANG Yaoxing; DONG Wenbin

    2012-01-01

    This paper deals with the high performance force control of hydraulic load samulator.Many prevtous works for hydraultc force control are based on their linearization equations,but hydraulic inherent nonlinear properties and uncertainties make the conventional feedback proportional-integral-derivative control not yield to high-performance requirements.In this paper,a nonlinear system model is derived and linear parameterization is made for adaptive control.Then a discontinuous projection-based nonlinear adaptive robust force controller is developed for hydraulic load simulator.The proposed controller constructs an asymptotically stable adaptive controller and adaptation laws,which can compensate for the system nonlinearities and uncertain parameters.Meanwhile a well-designed robust controller is also developed to cope with the hydraulic system uncertain nonlinearities.The controller achieves a guaranteed transient performance and final tracking accuracy in the presence of both parametric uncertainties and uncertain nonlinearities; in the absence of uncertain nonlinearities,the scheme also achieves asymptotic tracking performance.Simulation and experiment comparative results are obtained to verify the high-performance nature of the proposed control strategy and the tracking accuracy is greatly improved.

  6. UNFOLDING SIMULATIONS OF COLD- AND WARM-ADAPTED ELASTASES

    Directory of Open Access Journals (Sweden)

    Laura Riccardi1, Papaleo Elena2 *

    2010-11-01

    Full Text Available The earth surface is dominated by low temperature environments, which have been successfully colonized by several extremophilic organisms. Enzymes isolated from psychrophilic organisms are able to catalyze reactions at low temperatures at which enzymes from mesophiles or thermophiles are fully compromised. The current scenario on enzyme cold-adaptation suggest that these enzymes are characterized by higher catalytic efficiently at low temperatures, enhanced structural flexibility and lower thermostability. In the present contribution, molecular dynamics simulations in explicit solvent have been carried out at different high temperatures in order to investigate the unfolding process of cold- and warm-adapted homologous enzymes. In particular, we focused our attention on cold-adapted elastases for which it was previously demonstrated that the psychrophilic enzyme presents higher localized flexibility in loops surrounding the catalytic site and the specificity pocket. The unfolding simulations show a slower unfolding process for the cold-adapted enzyme, but characterized by a greater loss of intramolecular interactions and α-helices than the mesophilic counterparts.

  7. Adaptive scapula bone remodeling computational simulation: Relevance to regenerative medicine

    Energy Technology Data Exchange (ETDEWEB)

    Sharma, Gulshan B., E-mail: gbsharma@ucalgary.ca [Emory University, Department of Radiology and Imaging Sciences, Spine and Orthopaedic Center, Atlanta, Georgia 30329 (United States); University of Pittsburgh, Swanson School of Engineering, Department of Bioengineering, Pittsburgh, Pennsylvania 15213 (United States); University of Calgary, Schulich School of Engineering, Department of Mechanical and Manufacturing Engineering, Calgary, Alberta T2N 1N4 (Canada); Robertson, Douglas D., E-mail: douglas.d.robertson@emory.edu [Emory University, Department of Radiology and Imaging Sciences, Spine and Orthopaedic Center, Atlanta, Georgia 30329 (United States); University of Pittsburgh, Swanson School of Engineering, Department of Bioengineering, Pittsburgh, Pennsylvania 15213 (United States)

    2013-07-01

    Shoulder arthroplasty success has been attributed to many factors including, bone quality, soft tissue balancing, surgeon experience, and implant design. Improved long-term success is primarily limited by glenoid implant loosening. Prosthesis design examines materials and shape and determines whether the design should withstand a lifetime of use. Finite element (FE) analyses have been extensively used to study stresses and strains produced in implants and bone. However, these static analyses only measure a moment in time and not the adaptive response to the altered environment produced by the therapeutic intervention. Computational analyses that integrate remodeling rules predict how bone will respond over time. Recent work has shown that subject-specific two- and three dimensional adaptive bone remodeling models are feasible and valid. Feasibility and validation were achieved computationally, simulating bone remodeling using an intact human scapula, initially resetting the scapular bone material properties to be uniform, numerically simulating sequential loading, and comparing the bone remodeling simulation results to the actual scapula’s material properties. Three-dimensional scapula FE bone model was created using volumetric computed tomography images. Muscle and joint load and boundary conditions were applied based on values reported in the literature. Internal bone remodeling was based on element strain-energy density. Initially, all bone elements were assigned a homogeneous density. All loads were applied for 10 iterations. After every iteration, each bone element’s remodeling stimulus was compared to its corresponding reference stimulus and its material properties modified. The simulation achieved convergence. At the end of the simulation the predicted and actual specimen bone apparent density were plotted and compared. Location of high and low predicted bone density was comparable to the actual specimen. High predicted bone density was greater than

  8. Adaptive scapula bone remodeling computational simulation: Relevance to regenerative medicine

    International Nuclear Information System (INIS)

    Shoulder arthroplasty success has been attributed to many factors including, bone quality, soft tissue balancing, surgeon experience, and implant design. Improved long-term success is primarily limited by glenoid implant loosening. Prosthesis design examines materials and shape and determines whether the design should withstand a lifetime of use. Finite element (FE) analyses have been extensively used to study stresses and strains produced in implants and bone. However, these static analyses only measure a moment in time and not the adaptive response to the altered environment produced by the therapeutic intervention. Computational analyses that integrate remodeling rules predict how bone will respond over time. Recent work has shown that subject-specific two- and three dimensional adaptive bone remodeling models are feasible and valid. Feasibility and validation were achieved computationally, simulating bone remodeling using an intact human scapula, initially resetting the scapular bone material properties to be uniform, numerically simulating sequential loading, and comparing the bone remodeling simulation results to the actual scapula’s material properties. Three-dimensional scapula FE bone model was created using volumetric computed tomography images. Muscle and joint load and boundary conditions were applied based on values reported in the literature. Internal bone remodeling was based on element strain-energy density. Initially, all bone elements were assigned a homogeneous density. All loads were applied for 10 iterations. After every iteration, each bone element’s remodeling stimulus was compared to its corresponding reference stimulus and its material properties modified. The simulation achieved convergence. At the end of the simulation the predicted and actual specimen bone apparent density were plotted and compared. Location of high and low predicted bone density was comparable to the actual specimen. High predicted bone density was greater than

  9. The limits of the adaptation of life to extreme conditions (in connection with problems of exobiology)

    Science.gov (United States)

    Aksenov, S. I.

    1973-01-01

    Accommodation is discussed as a universal evolutionary principle which essentially will apply to all life forms, regardless of chemical base (carbon, silicon, etc.). Life forms must either adapt to extreme conditions or perish, and for any life form an extremum factor is any significant deviation in environmental parameters. The possibility of life forms existing in specific extraterrestrial environments is discussed, and a conclusion is drawn which unequivocally states that through many forms of accommodation life is possible in many different environments.

  10. Advanced Dynamically Adaptive Algorithms for Stochastic Simulations on Extreme Scales

    Energy Technology Data Exchange (ETDEWEB)

    Xiu, Dongbin [Purdue Univ., West Lafayette, IN (United States)

    2016-06-21

    The focus of the project is the development of mathematical methods and high-performance com- putational tools for stochastic simulations, with a particular emphasis on computations on extreme scales. The core of the project revolves around the design of highly e cient and scalable numer- ical algorithms that can adaptively and accurately, in high dimensional spaces, resolve stochastic problems with limited smoothness, even containing discontinuities.

  11. Improvement of flight simulator feeling using adaptive fuzzy backlash compensation

    OpenAIRE

    Amara, Zied; Bordeneuve-Guibé, Joël

    2007-01-01

    In this paper we addressed the problem of improving the control of DC motors used for the specific application of a 3 degrees of freedom moving base flight simulator. Indeed the presence of backlash in DC motors gearboxes induces shocks and naturally limits the flight feeling. In this paper, dynamic inversion with Fuzzy Logic is used to design an adaptive backlash compensator. The classification property of fuzzy logic techniques makes them a natural candidate for the rejection of errors indu...

  12. An adaptive nonlinear solution scheme for reservoir simulation

    Energy Technology Data Exchange (ETDEWEB)

    Lett, G.S. [Scientific Software - Intercomp, Inc., Denver, CO (United States)

    1996-12-31

    Numerical reservoir simulation involves solving large, nonlinear systems of PDE with strongly discontinuous coefficients. Because of the large demands on computer memory and CPU, most users must perform simulations on very coarse grids. The average properties of the fluids and rocks must be estimated on these grids. These coarse grid {open_quotes}effective{close_quotes} properties are costly to determine, and risky to use, since their optimal values depend on the fluid flow being simulated. Thus, they must be found by trial-and-error techniques, and the more coarse the grid, the poorer the results. This paper describes a numerical reservoir simulator which accepts fine scale properties and automatically generates multiple levels of coarse grid rock and fluid properties. The fine grid properties and the coarse grid simulation results are used to estimate discretization errors with multilevel error expansions. These expansions are local, and identify areas requiring local grid refinement. These refinements are added adoptively by the simulator, and the resulting composite grid equations are solved by a nonlinear Fast Adaptive Composite (FAC) Grid method, with a damped Newton algorithm being used on each local grid. The nonsymmetric linear system of equations resulting from Newton`s method are in turn solved by a preconditioned Conjugate Gradients-like algorithm. The scheme is demonstrated by performing fine and coarse grid simulations of several multiphase reservoirs from around the world.

  13. Spaceflight Sensorimotor Analogs: Simulating Acute and Adaptive Effects

    Science.gov (United States)

    Taylor, Laura C.; Harm, Deborah L.; Kozlovskaya, Inessa; Reschke, Millard F.; Wood, Scott J.

    2009-01-01

    Adaptive changes in sensorimotor function during spaceflight are reflected by spatial disorientation, motion sickness, gaze destabilization and decrements in balance, locomotion and eye-hand coordination that occur during and following transitions between different gravitational states. The purpose of this study was to conduct a meta-synthesis of data from spaceflight analogs to evaluate their effectiveness in simulating adaptive changes in sensorimotor function. METHODS. The analogs under review were categorized as either acute analogs used to simulate performance decrements accompanied with transient changes, or adaptive analogs used to drive sensorimotor learning to altered sensory feedback. The effectiveness of each analog was evaluated in terms of mechanisms of action, magnitude and time course of observed deficits compared to spaceflight data, and the effects of amplitude and exposure duration. RESULTS. Parabolic flight has been used extensively to examine effects of acute variation in gravitational loads, ranging from hypergravity to microgravity. More recently, galvanic vestibular stimulation has been used to elicit acute postural, locomotor and gaze dysfunction by disrupting vestibular afferents. Patient populations, e.g., with bilateral vestibular loss or cerebellar dysfunction, have been proposed to model acute sensorimotor dysfunction. Early research sponsored by NASA involved living onboard rotating rooms, which appeared to approximate the time course of adaptation and post-exposure recovery observed in astronauts following spaceflight. Exposure to different bed-rest paradigms (6 deg head down, dry immersion) result in similar motor deficits to that observed following spaceflight. Shorter adaptive analogs have incorporated virtual reality environments, visual distortion paradigms, exposure to conflicting tilt-translation cues, and exposure to 3Gx centrifugation. As with spaceflight, there is considerable variability in responses to most of the analogs

  14. Hydrodynamical Adaptive Mesh Refinement Simulations of Disk Galaxies

    CERN Document Server

    Gibson, Brad K; Sanchez-Blazquez, Patricia; Teyssier, Romain; House, Elisa L; Brook, Chris B; Kawata, Daisuke

    2008-01-01

    To date, fully cosmological hydrodynamic disk simulations to redshift zero have only been undertaken with particle-based codes, such as GADGET, Gasoline, or GCD+. In light of the (supposed) limitations of traditional implementations of smoothed particle hydrodynamics (SPH), or at the very least, their respective idiosyncrasies, it is important to explore complementary approaches to the SPH paradigm to galaxy formation. We present the first high-resolution cosmological disk simulations to redshift zero using an adaptive mesh refinement (AMR)-based hydrodynamical code, in this case, RAMSES. We analyse the temporal and spatial evolution of the simulated stellar disks' vertical heating, velocity ellipsoids, stellar populations, vertical and radial abundance gradients (gas and stars), assembly/infall histories, warps/lopsideness, disk edges/truncations (gas and stars), ISM physics implementations, and compare and contrast these properties with our sample of cosmological SPH disks, generated with GCD+. These prelim...

  15. Virtual Retail Simulations in Second Life

    Science.gov (United States)

    Drake-Bridges, Erin; Strelzoff, Andrew; Sulbaran, Tulio

    2011-01-01

    This paper explores the use of simulations in virtual reality to teach students the fundamental processes behind retailing and product development. The project described involved one class of students who developed their own clothing lines of "virtual merchandise." A second class of students then "purchased" the wholesale virtual goods and…

  16. An Evolutionary Agent-based simulation model for the industry life cycle

    OpenAIRE

    Lehmann-Waffenschmidt, B. Cornelia

    2008-01-01

    In contrast to the usual approach taken in the literature, in which an Industry Life Cycle (ILC) is reproduced by aggregate functions, the model of this paper generates a self-organizing ILC. A general evolutionary agent-based simulation model is developed that can be adapted for specific branches of industry. The results enable conclusions to be drawn for competition policy with regard to the workability of competition in the various phases of the ILC.

  17. A parallel adaptive finite difference algorithm for petroleum reservoir simulation

    Energy Technology Data Exchange (ETDEWEB)

    Hoang, Hai Minh

    2005-07-01

    Adaptive finite differential for problems arising in simulation of flow in porous medium applications are considered. Such methods have been proven useful for overcoming limitations of computational resources and improving the resolution of the numerical solutions to a wide range of problems. By local refinement of the computational mesh where it is needed to improve the accuracy of solutions, yields better solution resolution representing more efficient use of computational resources than is possible with traditional fixed-grid approaches. In this thesis, we propose a parallel adaptive cell-centered finite difference (PAFD) method for black-oil reservoir simulation models. This is an extension of the adaptive mesh refinement (AMR) methodology first developed by Berger and Oliger (1984) for the hyperbolic problem. Our algorithm is fully adaptive in time and space through the use of subcycling, in which finer grids are advanced at smaller time steps than the coarser ones. When coarse and fine grids reach the same advanced time level, they are synchronized to ensure that the global solution is conservative and satisfy the divergence constraint across all levels of refinement. The material in this thesis is subdivided in to three overall parts. First we explain the methodology and intricacies of AFD scheme. Then we extend a finite differential cell-centered approximation discretization to a multilevel hierarchy of refined grids, and finally we are employing the algorithm on parallel computer. The results in this work show that the approach presented is robust, and stable, thus demonstrating the increased solution accuracy due to local refinement and reduced computing resource consumption. (Author)

  18. Adaptive mesh refinement and adjoint methods in geophysics simulations

    Science.gov (United States)

    Burstedde, Carsten

    2013-04-01

    It is an ongoing challenge to increase the resolution that can be achieved by numerical geophysics simulations. This applies to considering sub-kilometer mesh spacings in global-scale mantle convection simulations as well as to using frequencies up to 1 Hz in seismic wave propagation simulations. One central issue is the numerical cost, since for three-dimensional space discretizations, possibly combined with time stepping schemes, a doubling of resolution can lead to an increase in storage requirements and run time by factors between 8 and 16. A related challenge lies in the fact that an increase in resolution also increases the dimensionality of the model space that is needed to fully parametrize the physical properties of the simulated object (a.k.a. earth). Systems that exhibit a multiscale structure in space are candidates for employing adaptive mesh refinement, which varies the resolution locally. An example that we found well suited is the mantle, where plate boundaries and fault zones require a resolution on the km scale, while deeper area can be treated with 50 or 100 km mesh spacings. This approach effectively reduces the number of computational variables by several orders of magnitude. While in this case it is possible to derive the local adaptation pattern from known physical parameters, it is often unclear what are the most suitable criteria for adaptation. We will present the goal-oriented error estimation procedure, where such criteria are derived from an objective functional that represents the observables to be computed most accurately. Even though this approach is well studied, it is rarely used in the geophysics community. A related strategy to make finer resolution manageable is to design methods that automate the inference of model parameters. Tweaking more than a handful of numbers and judging the quality of the simulation by adhoc comparisons to known facts and observations is a tedious task and fundamentally limited by the turnaround times

  19. Direct numerical simulation of bubbles with parallelized adaptive mesh refinement

    International Nuclear Information System (INIS)

    The study of two-phase Thermal-Hydraulics is a major topic for Nuclear Engineering for both security and efficiency of nuclear facilities. In addition to experiments, numerical modeling helps to knowing precisely where bubbles appear and how they behave, in the core as well as in the steam generators. This work presents the finest scale of representation of two-phase flows, Direct Numerical Simulation of bubbles. We use the 'Di-phasic Low Mach Number' equation model. It is particularly adapted to low-Mach number flows, that is to say flows which velocity is much slower than the speed of sound; this is very typical of nuclear thermal-hydraulics conditions. Because we study bubbles, we capture the front between vapor and liquid phases thanks to a downward flux limiting numerical scheme. The specific discrete analysis technique this work introduces is well-balanced parallel Adaptive Mesh Refinement (AMR). With AMR, we refined the coarse grid on a batch of patches in order to locally increase precision in areas which matter more, and capture fine changes in the front location and its topology. We show that patch-based AMR is very adapted for parallel computing. We use a variety of physical examples: forced advection, heat transfer, phase changes represented by a Stefan model, as well as the combination of all those models. We will present the results of those numerical simulations, as well as the speed up compared to equivalent non-AMR simulation and to serial computation of the same problems. This document is made up of an abstract and the slides of the presentation. (author)

  20. Adaptive Techniques for Clustered N-Body Cosmological Simulations

    CERN Document Server

    Menon, Harshitha; Zheng, Gengbin; Jetley, Pritish; Kale, Laxmikant; Quinn, Thomas; Governato, Fabio

    2014-01-01

    ChaNGa is an N-body cosmology simulation application implemented using Charm++. In this paper, we present the parallel design of ChaNGa and address many challenges arising due to the high dynamic ranges of clustered datasets. We focus on optimizations based on adaptive techniques for scaling to more than 128K cores. We demonstrate strong scaling on up to 512K cores of Blue Waters evolving 12 and 24 billion particles. We also show strong scaling of highly clustered datasets on up to 128K cores.

  1. Local adaptation in brown trout early life-history traits: implications for climate change adaptability

    DEFF Research Database (Denmark)

    Jensen, L.F.; Hansen, Michael Møller; Pertoldi, C.;

    2008-01-01

      Knowledge of local adaptation and adaptive potential of natural populations is becoming increasingly relevant due to anthropogenic changes in the environment, such as climate change. The concern is that populations will be negatively affected by increasing temperatures without the capacity...... and heritable variation in phenotypic plasticity suggest that although increasing temperatures are likely to affect some populations negatively, they may have the potential to adapt to changing temperature regimes.  ...

  2. The yak genome and adaptation to life at high altitude

    DEFF Research Database (Denmark)

    Qiu, Qiang; Zhang, Guojie; Ma, Tao;

    2012-01-01

    Domestic yaks (Bos grunniens) provide meat and other necessities for Tibetans living at high altitude on the Qinghai-Tibetan Plateau and in adjacent regions. Comparison between yak and the closely related low-altitude cattle (Bos taurus) is informative in studying animal adaptation to high altitude...... of protein domains involved in sensing the extracellular environment and hypoxic stress. Positively selected and rapidly evolving genes in the yak lineage are also found to be significantly enriched in functional categories and pathways related to hypoxia and nutrition metabolism. These findings may have...... important implications for understanding adaptation to high altitude in other animal species and for hypoxia-related diseases in humans....

  3. Adaptive resolution simulation of polarizable supramolecular coarse-grained water models

    NARCIS (Netherlands)

    Zavadlav, Julija; Melo, Manuel N.; Marrink, Siewert J.; Praprotnik, Matej

    2015-01-01

    Multiscale simulations methods, such as adaptive resolution scheme, are becoming increasingly popular due to their significant computational advantages with respect to conventional atomistic simulations. For these kind of simulations, it is essential to develop accurate multiscale water models that

  4. Structural considerations for a software life cycle dynamic simulation model

    Science.gov (United States)

    Tausworthe, R. C.; Mckenzie, M.; Lin, C. Y.

    1983-01-01

    This paper presents the results of a preliminary study into the prospects for simulating the software implementation and maintenance life cycle process, with the aim of producing a computerized tool for use by management and software engineering personnel in project planning, tradeoff studies involving product, environmental, situational, and technological factors, and training. The approach taken is the modular application of a 'flow of resource' concept to the systems dynamics simulation modeling technique. The software life cycle process is represented as a number of stochastic, time-varying, interacting work tasks that each achieves one of the project milestones. Each task is characterized by the item produced, the personnel applied, and the budgetary profile.

  5. Early life stages contribute strongly to local adaptation in Arabidopsis thaliana.

    Science.gov (United States)

    Postma, Froukje M; Ågren, Jon

    2016-07-01

    The magnitude and genetic basis of local adaptation is of fundamental interest in evolutionary biology. However, field experiments usually do not consider early life stages, and therefore may underestimate local adaptation and miss genetically based tradeoffs. We examined the contribution of differences in seedling establishment to adaptive differentiation and the genetic architecture of local adaptation using recombinant inbred lines (RIL) derived from a cross between two locally adapted populations (Italy and Sweden) of the annual plant Arabidopsis thaliana We planted freshly matured, dormant seeds (>180 000) representing >200 RILs at the native field sites of the parental genotypes, estimated the strength of selection during different life stages, mapped quantitative trait loci (QTL) for fitness and its components, and quantified selection on seed dormancy. We found that selection during the seedling establishment phase contributed strongly to the fitness advantage of the local genotype at both sites. With one exception, local alleles of the eight distinct establishment QTL were favored. The major QTL for establishment and total fitness showed evidence of a fitness tradeoff and was located in the same region as the major seed dormancy QTL and the dormancy gene DELAY OF GERMINATION 1 (DOG1). RIL seed dormancy could explain variation in seedling establishment and fitness across the life cycle. Our results demonstrate that genetically based differences in traits affecting performance during early life stages can contribute strongly to adaptive differentiation and genetic tradeoffs, and should be considered for a full understanding of the ecology and genetics of local adaptation. PMID:27330113

  6. Adapting a weather forecast model for greenhouse gas simulation

    Science.gov (United States)

    Polavarapu, S. M.; Neish, M.; Tanguay, M.; Girard, C.; de Grandpré, J.; Gravel, S.; Semeniuk, K.; Chan, D.

    2015-12-01

    The ability to simulate greenhouse gases on the global domain is useful for providing boundary conditions for regional flux inversions, as well as for providing reference data for bias correction of satellite measurements. Given the existence of operational weather and environmental prediction models and assimilation systems at Environment Canada, it makes sense to use these tools for greenhouse gas simulations. In this work, we describe the adaptations needed to reasonably simulate CO2 with a weather forecast model. The main challenges were the implementation of a mass conserving advection scheme, and the careful implementation of a mixing ratio defined with respect to dry air. The transport of tracers through convection was also added, and the vertical mixing through the boundary layer was slightly modified. With all these changes, the model conserves CO2 mass well on the annual time scale, and the high resolution (0.9 degree grid spacing) permits a good description of synoptic scale transport. The use of a coupled meteorological/tracer transport model also permits an assessment of approximations needed in offline transport model approaches, such as the neglect of water vapour mass when computing a tracer mixing ratio with respect to dry air.

  7. Vibrio Iron Transport: Evolutionary Adaptation to Life in Multiple Environments.

    Science.gov (United States)

    Payne, Shelley M; Mey, Alexandra R; Wyckoff, Elizabeth E

    2016-03-01

    Iron is an essential element for Vibrio spp., but the acquisition of iron is complicated by its tendency to form insoluble ferric complexes in nature and its association with high-affinity iron-binding proteins in the host. Vibrios occupy a variety of different niches, and each of these niches presents particular challenges for acquiring sufficient iron. Vibrio species have evolved a wide array of iron transport systems that allow the bacteria to compete for this essential element in each of its habitats. These systems include the secretion and uptake of high-affinity iron-binding compounds (siderophores) as well as transport systems for iron bound to host complexes. Transporters for ferric and ferrous iron not complexed to siderophores are also common to Vibrio species. Some of the genes encoding these systems show evidence of horizontal transmission, and the ability to acquire and incorporate additional iron transport systems may have allowed Vibrio species to more rapidly adapt to new environmental niches. While too little iron prevents growth of the bacteria, too much can be lethal. The appropriate balance is maintained in vibrios through complex regulatory networks involving transcriptional repressors and activators and small RNAs (sRNAs) that act posttranscriptionally. Examination of the number and variety of iron transport systems found in Vibrio spp. offers insights into how this group of bacteria has adapted to such a wide range of habitats.

  8. Adaptive model reduction for nonsmooth discrete element simulation

    CERN Document Server

    Servin, Martin

    2015-01-01

    A method for adaptive model order reduction for nonsmooth discrete element simulation is developed and analysed in numerical experiments. Regions of the granular media that collectively move as rigid bodies are substituted with rigid bodies of the corresponding shape and mass distribution. The method also support particles merging with articulated multibody systems. A model approximation error is defined used for deriving and conditions for when and where to apply model reduction and refinement back into particles and smaller rigid bodies. Three methods for refinement are proposed and tested: prediction from contact events, trial solutions computed in the background and using split sensors. The computational performance can be increased by 5 - 50 times for model reduction level between 70 - 95 %.

  9. Thermal Modeling and Feedback Requirements for LIFE Neutronic Simulations

    Energy Technology Data Exchange (ETDEWEB)

    Seifried, J E

    2009-07-15

    An initial study is performed to determine how temperature considerations affect LIFE neutronic simulations. Among other figures of merit, the isotopic mass accumulation, thermal power, tritium breeding, and criticality are analyzed. Possible fidelities of thermal modeling and degrees of coupling are explored. Lessons learned from switching and modifying nuclear datasets is communicated.

  10. Unsteady CFD simulations of a pump in part load conditions using scale-adaptive simulation

    Energy Technology Data Exchange (ETDEWEB)

    Lucius, A., E-mail: andreas.lucius@tu-clausthal.d [Institute of Applied Mechanics, Clausthal University of Technology, Adolph-Roemer Str. 2a, 38678 Clausthal-Zellerfeld (Germany); Brenner, G. [Institute of Applied Mechanics, Clausthal University of Technology, Adolph-Roemer Str. 2a, 38678 Clausthal-Zellerfeld (Germany)

    2010-12-15

    The scope of this work is to demonstrate the applicability of an eddy resolving turbulence model in a turbomachinery configuration. The model combines the Large Eddy Simulation (LES) and the Reynolds Averaged Navier Stokes (RANS) approach. The point of interest of the present investigation is the unsteady rotating stall phenomenon occurring at low part load conditions. Since RANS turbulence models often fail to predict separation correctly, a LES like model is expected to give superior results. In this investigation the scale-adaptive simulation (SAS) model is used. This model avoids the grid dependence appearing in the Detached Eddy Simulation (DES) modelling strategy. The simulations are validated with transient measurement data. The present results demonstrate, that both models are able to predict the major stall frequency at part load. Results are similar for URANS and SAS, with advantages in predicting minor stall frequencies for the turbulence resolving model.

  11. Adaptive responses of energy storage and fish life histories to climatic gradients.

    Science.gov (United States)

    Giacomini, Henrique C; Shuter, Brian J

    2013-12-21

    Energy storage is a common adaptation of fish living in seasonal environments. For some species, the energy accumulated during the growing season, and stored primarily as lipids, is crucial to preventing starvation mortality over winter. Thus, in order to understand the adaptive responses of fish life history to climate, it is important to determine how energy should be allocated to storage and how it trades off with the other body components that contribute to fitness. In this paper, we extend previous life history theory to include an explicit representation of how the seasonal allocation of energy to storage acts as a constraint on fish growth. We show that a strategy that privileges allocation to structural mass in the first part of the growing season and switches to storage allocation later on, as observed empirically in several fish species, is the strategy that maximizes growth efficiency and hence is expected to be favored by natural selection. Stochastic simulations within this theoretical framework demonstrate that the relative performance of this switching strategy is robust to a wide range of fluctuations in growing season length, and to moderate short-term (i.e., daily) fluctuations in energy intake and/or expenditure within the growing season. We then integrate this switching strategy with a biphasic growth modeling framework to predict typical growth rates of walleye Sander vitreus, a cool water species, and lake trout Salvelinus namaycush, a cold water specialist, across a climatic gradient in North America. As predicted, growth rates increased linearly with the duration of the growing season. Regression line intercepts were negative, indicating that growth can only occur when growing season length exceeds a threshold necessary to produce storage for winter survival. The model also reveals important differences between species, showing that observed growth rates of lake trout are systematically higher than those of walleye in relatively colder lakes

  12. Computational Simulation of Hypervelocity Penetration Using Adaptive SPH Method

    Institute of Scientific and Technical Information of China (English)

    QIANG Hongfu; MENG Lijun

    2006-01-01

    The normal hypervelocity impact of an Al-thin plate by an Al-sphere was numerically simulated by using the adaptive smoothed particle hydrodynamics (ASPH) method.In this method,the isotropic smoothing algorithm of standard SPH is replaced with anisotropic smoothing involving ellipsoidal kernels whose axes evolve automatically to follow the mean particle spacing as it varies in time,space,and direction around each particle.Using the ASPH,the anisotropic volume changes under strong shock condition are captured more accurately and clearly.The sophisticated features of meshless and Lagrangian nature inherent in the SPH method are kept for treating large deformations,large inhomogeneities and tracing free surfaces in the extremely transient impact process.A two-dimensional ASPH program is coded with C + +.The developed hydrocode is examined for example problems of hypervelocity impacts of solid materials.The results obtained from the numerical simulation are compared with available experimental ones.Good agreement is observed.

  13. FATIGUE LIFE EVALUATION OF SUSPENSION KNUCKLE USING MULTIBODY SIMULATION TECHNIQUE

    Directory of Open Access Journals (Sweden)

    A.G.A. Rahman

    2012-12-01

    Full Text Available Suspension is part of automotive systems, providing both vehicle control and passenger comfort. The knuckle is an important part within the suspension system, constantly encountering the cyclic loads subjecting it to fatigue failure. This paper presents an evaluation of the fatigue characteristics of a knuckle using multibody simulation (MBS techniques. Load time history extracted from the MBS is used for stress analysis. An actual road profile of road bumps was used as the input to MBS. The stress fluctuations for fatigue simulations are considered with the road profile. The strain-life method is utilized to assess the fatigue life. The instantaneous stress distributions and maximum principal stress are used for fatigue life predictions. Mesh sensitivity analysis has been performed. The results show that the steering link in the knuckle is found to be the most susceptible region for fatigue failure. The number of times the knuckle can manage a road bump at 40 km/hr is determined to be approximately 371 times with a 50% certainty of survival. The proposed method of using the loading time history extracted from MBS simulation for fatigue life estimation is found to be very promising for the accurate evaluation of the performance of suspension system components.

  14. Subjective well-being and adaptation to life events: a meta-analysis.

    Science.gov (United States)

    Luhmann, Maike; Hofmann, Wilhelm; Eid, Michael; Lucas, Richard E

    2012-03-01

    Previous research has shown that major life events can have short- and long-term effects on subjective well-being (SWB). The present meta-analysis examines (a) whether life events have different effects on affective and cognitive well-being and (b) how the rate of adaptation varies across different life events. Longitudinal data from 188 publications (313 samples, N = 65,911) were integrated to describe the reaction and adaptation to 4 family events (marriage, divorce, bereavement, childbirth) and 4 work events (unemployment, reemployment, retirement, relocation/migration). The findings show that life events have very different effects on affective and cognitive well-being and that for most events the effects of life events on cognitive well-being are stronger and more consistent across samples. Different life events differ in their effects on SWB, but these effects are not a function of the alleged desirability of events. The results are discussed with respect to their theoretical implications, and recommendations for future studies on adaptation are given.

  15. "Replaying Life's Tape": Simulations, metaphors, and historicity in Stephen Jay Gould's view of life.

    Science.gov (United States)

    Sepkoski, David

    2016-08-01

    In a famous thought experiment, Stephen Jay Gould asked whether, if one could somehow rewind the history of life back to its initial starting point, the same results would obtain when the "tape" was run forward again. This hypothetical experiment is generally understood as a metaphor supporting Gould's philosophy of evolutionary contingency, which he developed and promoted from the late 1980s until his death in 2002. However, there was a very literal, non-metaphorical inspiration for Gould's thought experiment: since the early 1970s, Gould, along with a group of other paleontologists, was actively engaged in attempts to model and reconstruct the history of life using computer simulations and database analysis. These simulation projects not only demonstrate the impact that computers had on data analysis in paleontology, but also shed light on the close relationship between models and empirical data in data-oriented science. In a sense, I will argue, the models developed by paleontologists through simulation and quantitative analysis of the empirical fossil record in the 1970s and beyond were literal attempts to "replay life's tape" by reconstructing the history of life as data. PMID:26790344

  16. The Impact of Different Portability Factors during the Life Cycle of an Educational Software Adaptation Project.

    Science.gov (United States)

    Collis, Betty A.; De Diana, Italo

    1990-01-01

    Provides an example that illustrates the interrelationship of the factors that influence educational software portability. Nielsen's seven-level approach to human-computer interaction is used as the basis for a model for factors that influence portability, and five phases in the life cycle of a software product being adapted are considered. (10…

  17. Adaptive and Maladaptive Perfectionism as Mediators of Adult Attachment Styles and Depression, Hopelessness, and Life Satisfaction

    Science.gov (United States)

    Gnilka, Philip B.; Ashby, Jeffrey S.; Noble, Christina M.

    2013-01-01

    This study examined the relationships between adaptive and maladaptive perfectionism, anxious and avoidant adult attachment styles, depression, hopelessness, and life satisfaction among a sample of 180 undergraduate students. Maladaptive perfectionism mediated the relationship between both forms of adult attachment and depression, hopelessness,…

  18. Psychometric Characteristics of the Korean Version of the Satisfaction with Life Scale Adapted for Children

    Science.gov (United States)

    Lim, Young-Jin

    2015-01-01

    The aim of this study was to examine the internal consistency reliability, test-retest reliability, factorial structure validity, and convergent validity of a Korean version of the Satisfaction With Life Scale adapted for children (K-SWLS-C). Participants consisted of 653 elementary school students (48% were male). The internal consistency of the…

  19. Simulating adaptive wood harvest in a changing climate

    Science.gov (United States)

    Yousefpour, Rasoul; Nabel, Julia; Pongratz, Julia

    2016-04-01

    The world's forest experience substantial carbon exchange fluxes between land and atmosphere. Large carbon sinks occur in response to changes in environmental conditions (such as climate change and increased atmospheric CO2 concentrations), removing about one quarter of current anthropogenic CO2-emissions. Large sinks also occur due to regrowth of forest on areas of agricultural abandonment or forest management. Forest management, on the other hand, also leads to substantial amounts of carbon being eventually released to the atmosphere. Both sinks and sources attributable to forests are therefore dependent on the intensity of management. Forest management in turn depends on the availability of resources, which is influenced by environmental conditions and sustainability of management systems applied. Estimating future carbon fluxes therefore requires accounting for the interaction of environmental conditions, forest growth, and management. However, this interaction is not fully captured by current modeling approaches: Earth system models depict in detail interactions between climate, the carbon cycle, and vegetation growth, but use prescribed information on management. Resource needs and land management, however, are simulated by Integrated Assessment Models that typically only have coarse representations of the influence of environmental changes on vegetation growth and are typically based on the demand for wood driven by regional population growth and energy needs. Here we present a study that provides the link between environmental conditions, forest growth and management. We extend the land component JSBACH of the Max Planck Institute's Earth system model (MPI-ESM) to simulate potential wood harvest in response to altered growth conditions and thus as adaptive to changing climate and CO2 conditions. We apply the altered model to estimate potential wood harvest for future climates (representative concentration pathways, RCPs) for the management scenario of

  20. Visual adaptation of the perception of "life": animacy is a basic perceptual dimension of faces.

    Science.gov (United States)

    Koldewyn, Kami; Hanus, Patricia; Balas, Benjamin

    2014-08-01

    One critical component of understanding another's mind is the perception of "life" in a face. However, little is known about the cognitive and neural mechanisms underlying this perception of animacy. Here, using a visual adaptation paradigm, we ask whether face animacy is (1) a basic dimension of face perception and (2) supported by a common neural mechanism across distinct face categories defined by age and species. Observers rated the perceived animacy of adult human faces before and after adaptation to (1) adult faces, (2) child faces, and (3) dog faces. When testing the perception of animacy in human faces, we found significant adaptation to both adult and child faces, but not dog faces. We did, however, find significant adaptation when morphed dog images and dog adaptors were used. Thus, animacy perception in faces appears to be a basic dimension of face perception that is species specific but not constrained by age categories.

  1. Life history trait differentiation and local adaptation in invasive populations of Ambrosia artemisiifolia in China.

    Science.gov (United States)

    Li, Xiao-Meng; She, Deng-Ying; Zhang, Da-Yong; Liao, Wan-Jin

    2015-03-01

    Local adaptation has been suggested to play an important role in range expansion, particularly among invasive species. However, the extent to which local adaptation affects the success of an invasive species and the factors that contribute to local adaptation are still unclear. This study aimed to investigate a case of population divergence that may have contributed to the local adaptation of invasive populations of Ambrosia artemisiifolia in China. Common garden experiments in seven populations indicated clinal variations along latitudinal gradients, with plants from higher latitudes exhibiting earlier flowering and smaller sizes at flowering. In reciprocal transplant experiments, plants of a northern Beijing origin produced more seeds at their home site than plants of a southern Wuhan origin, and the Wuhan-origin plants had grown taller at flowering than the Beijing-origin plants in Wuhan, which is believed to facilitate pollen dispersal. These results suggest that plants of Beijing origin may be locally adapted through female fitness and plants from Wuhan possibly locally adapted through male fitness. Selection and path analysis suggested that the phenological and growth traits of both populations have been influenced by natural selection and that flowering time has played an important role through its direct and indirect effects on the relative fitness of each individual. This study evidences the life history trait differentiation and local adaptation during range expansion of invasive A. artemisiifolia in China. PMID:25362583

  2. Development of life sciences equipment for microgravity and hypergravity simulation

    Science.gov (United States)

    Mulenburg, G. M.; Evans, J.; Vasques, M.; Gundo, D. P.; Griffith, J. B.; Harper, J.; Skundberg, T.

    1994-01-01

    The mission of the Life Science Division at the NASA Ames Research Center is to investigate the effects of gravity on living systems in the spectrum from cells to humans. The range of these investigations is from microgravity, as experienced in space, to Earth's gravity, and hypergravity. Exposure to microgravity causes many physiological changes in humans and other mammals including a headward shift of body fluids, atrophy of muscles - especially the large muscles of the legs - and changes in bone and mineral metabolism. The high cost and limited opportunity for research experiments in space create a need to perform ground based simulation experiments on Earth. Models that simulate microgravity are used to help identify and quantify these changes, to investigate the mechanisms causing these changes and, in some cases, to develop countermeasures.

  3. Bringing history to life: simulating landmark experiments in psychology.

    Science.gov (United States)

    Boynton, David M; Smith, Laurence D

    2006-05-01

    The course in history of psychology can be challenging for students, many of whom enter it with little background in history and faced with unfamiliar names and concepts. The sheer volume of material can encourage passive memorization unless efforts are made to increase student involvement. As part of a trend toward experiential history, historians of science have begun to supplement their lectures with demonstrations of classic physics experiments as a way to bring the history of science to life. Here, the authors report on computer simulations of five landmark experiments from early experimental psychology in the areas of reaction time, span of attention, and apparent motion. The simulations are designed not only to permit hands-on replication of historically important results but also to reproduce the experimental procedures closely enough that students can gain a feel for the nature of early research and the psychological processes being studied. PMID:17152604

  4. Quantum simulations of nuclei and nuclear pasta with the multiresolution adaptive numerical environment for scientific simulations

    Science.gov (United States)

    Sagert, I.; Fann, G. I.; Fattoyev, F. J.; Postnikov, S.; Horowitz, C. J.

    2016-05-01

    Background: Neutron star and supernova matter at densities just below the nuclear matter saturation density is expected to form a lattice of exotic shapes. These so-called nuclear pasta phases are caused by Coulomb frustration. Their elastic and transport properties are believed to play an important role for thermal and magnetic field evolution, rotation, and oscillation of neutron stars. Furthermore, they can impact neutrino opacities in core-collapse supernovae. Purpose: In this work, we present proof-of-principle three-dimensional (3D) Skyrme Hartree-Fock (SHF) simulations of nuclear pasta with the Multi-resolution ADaptive Numerical Environment for Scientific Simulations (MADNESS). Methods: We perform benchmark studies of 16O, 208Pb, and 238U nuclear ground states and calculate binding energies via 3D SHF simulations. Results are compared with experimentally measured binding energies as well as with theoretically predicted values from an established SHF code. The nuclear pasta simulation is initialized in the so-called waffle geometry as obtained by the Indiana University Molecular Dynamics (IUMD) code. The size of the unit cell is 24 fm with an average density of about ρ =0.05 fm-3 , proton fraction of Yp=0.3 , and temperature of T =0 MeV. Results: Our calculations reproduce the binding energies and shapes of light and heavy nuclei with different geometries. For the pasta simulation, we find that the final geometry is very similar to the initial waffle state. We compare calculations with and without spin-orbit forces. We find that while subtle differences are present, the pasta phase remains in the waffle geometry. Conclusions: Within the MADNESS framework, we can successfully perform calculations of inhomogeneous nuclear matter. By using pasta configurations from IUMD it is possible to explore different geometries and test the impact of self-consistent calculations on the latter.

  5. Early life stress, HPA axis adaptation and mechanisms contributing to later health outcomes

    Directory of Open Access Journals (Sweden)

    Jayanthi eManiam

    2014-05-01

    Full Text Available Stress activates the hypothalamic-pituitary-adrenal (HPA axis, which then modulates the degree of adaptation and response to a later stressor. It is known that early life stress can impact on later health but less is known about how early life stress impairs HPA axis activity, contributing to maladaptation of the stress response system. Early life stress exposure (either prenatally or in the early postnatal period can impact developmental pathways resulting in lasting structural and regulatory changes that predispose to adulthood disease. Epidemiological, clinical and experimental studies have demonstrated that early life stress produces long-term hyper responsiveness to stress with exaggerated circulating glucocorticoids, and enhanced anxiety and depression-like behaviours. Recently, evidence has emerged on early life stress induced metabolic derangements, for example hyperinsulinemia and altered insulin sensitivity on exposure to a high energy diet later in life. This draws our attention to the contribution of later environment to disease vulnerability. Early life stress can alter the expression of genes in peripheral tissues, such as the glucocorticoid receptor and 11-beta hydroxysteroid dehydrogenase (11β-HSD1. We propose that interactions between altered HPA axis activity and liver 11β-HSD1 modulates both tissue and circulating glucocorticoid availability, with adverse metabolic consequences. This review discusses the potential mechanisms underlying early life stress induced maladaptation of the HPA axis, and its subsequent effects on energy utilisation and expenditure. The effects of positive later environments as a means of ameliorating early life stress induced health deficits, and proposed mechanisms underpinning the interaction between early life stress and subsequent detrimental environmental exposures on metabolic risk will be outlined. Limitations in current methodology linking early life stress and later health outcomes will also

  6. Visual Simulation of Microalgae Growth in Bioregenerative Life Support System

    Science.gov (United States)

    Zhao, Ming

    Bioregenerative life support system is one of the key technologies for future human deep space exploration and long-term space missions. BLSS use biological system as its core unit in combination with other physical and chemical equipments, under the proper control and manipulation by crew to complete a specific task to support life. Food production, waste treatment, oxygen and water regeneration are all conducted by higher plants or microalgae in BLSS, which is the most import characteristic different from other kinds of life support systems. Microalgae is light autotrophic micro-organisms, light undoubtedly is the most import factor which limits its growth and reproduction. Increasing or decreasing the light intensity changes the growth rate of microalgae, and then regulates the concentration of oxygen and carbon dioxide in the system. In this paper, based on the mathematical model of microalgae which grew under the different light intensity, three-dimensional visualization model was built and realized through using 3ds max, Virtools and some other three dimensional software, in order to display its change and impacting on oxygen and carbon dioxide intuitively. We changed its model structure and parameters, such as establishing closed-loop control system, light intensity, temperature and Nutrient fluid’s velocity and so on, carried out computer virtual simulation, and observed dynamic change of system with the aim of providing visualization support for system research.

  7. Adaptations in the Treatment of Congenital Lymphedema Centered on the Quality of Life

    OpenAIRE

    Jose Maria Pereira de Godoy; Ana Paula Sanchez; Daniel Zucchi Libanore; Maria de Fatima Guerreiro Godoy

    2014-01-01

    Case Description. This report describes the evolution, necessary adaptations, and complications in the treatment of a 9-year-old child with primary congenital lymphedema. Description of Intervention. The clinical treatment of lymphedema was started in the first year of the patient’s life and for five years she was only treated using the Godoy & Godoy technique of cervical stimulation. Three years ago the patient was prescribed a compression stocki...

  8. Control and adaptation strategies for invasive species with different life history

    OpenAIRE

    Elofsson, Katarina; Gren, Ing-Marie

    2013-01-01

    The issue of timing and scope of policies to manage invasive species has achieved considerable attention in the economic literature. Whereas many earlier studies compare prevention and control for a single invading species, we focus instead on the optimal balance of adaptation and control when an invasive species competes for scarce resources with a resident species. In particular, we focus on the role that species’ life history, i.e. the degree of evolutionary specialization in survival or r...

  9. Cultural adaptation and validation of the Freiburg Life Quality Assessment - Wound Module to Brazilian Portuguese

    Directory of Open Access Journals (Sweden)

    Elaine Aparecida Rocha Domingues

    2016-01-01

    Full Text Available Objectives: to adapt the Freiburg Life Quality Assessment - Wound Module to Brazilian Portuguese and to measure its psychometric properties: reliability and validity. Method: the cultural adaptation was undertaken following the stages of translation, synthesis of the translations, back translation, committee of specialists, pre-test and focus group. A total of 200 patients participated in the study. These were recruited in Primary Care Centers, Family Health Strategy Centers, in a philanthropic hospital and in a teaching hospital. Reliability was assessed through internal consistency and stability. Validity was ascertained through the correlation of the instrument's values with those of the domains of the Ferrans and Powers Quality of Life Index - Wound Version and with the quality of life score of the visual analog scale. Results: the instrument presented adequate internal consistency (Cronbach alpha =0.86 and high stability in the test and retest (0.93. The validity presented correlations of moderate and significant magnitude (-0.24 to -0.48, p<0.0001. Conclusion: the results indicated that the adapted version presented reliable and valid psychometric measurements for the population with chronic wounds in the Brazilian culture.

  10. Cultural adaptation and validation of the Freiburg Life Quality Assessment - Wound Module to Brazilian Portuguese1

    Science.gov (United States)

    Domingues, Elaine Aparecida Rocha; Alexandre, Neusa Maria Costa; da Silva, José Vitor

    2016-01-01

    Objectives: to adapt the Freiburg Life Quality Assessment - Wound Module to Brazilian Portuguese and to measure its psychometric properties: reliability and validity. Method: the cultural adaptation was undertaken following the stages of translation, synthesis of the translations, back translation, committee of specialists, pre-test and focus group. A total of 200 patients participated in the study. These were recruited in Primary Care Centers, Family Health Strategy Centers, in a philanthropic hospital and in a teaching hospital. Reliability was assessed through internal consistency and stability. Validity was ascertained through the correlation of the instrument's values with those of the domains of the Ferrans and Powers Quality of Life Index - Wound Version and with the quality of life score of the visual analog scale. Results: the instrument presented adequate internal consistency (Cronbach alpha =0.86) and high stability in the test and retest (0.93). The validity presented correlations of moderate and significant magnitude (-0.24 to -0.48, p<0.0001). Conclusion: the results indicated that the adapted version presented reliable and valid psychometric measurements for the population with chronic wounds in the Brazilian culture. PMID:27143539

  11. Computerized adaptive measurement of depression: A simulation study

    Directory of Open Access Journals (Sweden)

    Mammen Oommen

    2004-05-01

    Full Text Available Abstract Background Efficient, accurate instruments for measuring depression are increasingly important in clinical practice. We developed a computerized adaptive version of the Beck Depression Inventory (BDI. We examined its efficiency and its usefulness in identifying Major Depressive Episodes (MDE and in measuring depression severity. Methods Subjects were 744 participants in research studies in which each subject completed both the BDI and the SCID. In addition, 285 patients completed the Hamilton Depression Rating Scale. Results The adaptive BDI had an AUC as an indicator of a SCID diagnosis of MDE of 88%, equivalent to the full BDI. The adaptive BDI asked fewer questions than the full BDI (5.6 versus 21 items. The adaptive latent depression score correlated r = .92 with the BDI total score and the latent depression score correlated more highly with the Hamilton (r = .74 than the BDI total score did (r = .70. Conclusions Adaptive testing for depression may provide greatly increased efficiency without loss of accuracy in identifying MDE or in measuring depression severity.

  12. A Model for Capturing Team Adaptation in Simulated Emergencies

    DEFF Research Database (Denmark)

    Paltved, Charlotte; Musaeus, Peter

    2013-01-01

    changes, adjust priorities and implement adjusted strategies were more likely to perform successfully in environments with unforeseen changes, in other words adaptability is the generalization of trained knowledge and skills to new, more difficult and more complex tasks. An interpretative approach...... events like closed-loop communication.1 A more nuanced understanding of team communication has the potential to enhance scholarship in interprofessional endeavours. In high risk environments, team performance depends on the ability of teams to quickly alter actions in response to rapidly changing...... conditions.2,3 However, research on team adaptation in healthcare is scarce.4 In this study, team adaptation in medical emergency teams was explored through the quality and content of updates. Updating is an ongoing process of incorporating interpretations based on new information with current beliefs.5...

  13. Adaptive resolution simulation of supramolecular water : The concurrent making, breaking, and remaking of water bundles

    NARCIS (Netherlands)

    Zavadlav, Julija; Marrink, Siewert J; Praprotnik, Matej

    2016-01-01

    The adaptive resolution scheme (AdResS) is a multiscale molecular dynamics simulation approach that can concurrently couple atomistic (AT) and coarse-grained (CG) resolution regions, i.e., the molecules can freely adapt their resolution according to their current position in the system. Coupling to

  14. Developing adaptive user interfaces using a game-based simulation environment

    NARCIS (Netherlands)

    Brake, G.M. te; Greef, T.E. de; Lindenberg, J.; Rypkema, J.A.; Smets-Noor, N.J.J.M.

    2006-01-01

    In dynamic settings, user interfaces can provide more optimal support if they adapt to the context of use. Providing adaptive user interfaces to first responders may therefore be fruitful. A cognitive engineering method that incorporates development iterations in both a simulated and a real-world en

  15. Toward a practical method for adaptive QM/MM simulations

    NARCIS (Netherlands)

    R.E. Bulo; B. Ensing; J. Sikkema; L. Visscher

    2009-01-01

    We present an accurate adaptive multiscale molecular dynamics method that will enable the detailed study of large molecular systems that mimic experiment. The method treats the reactive regions at the quantum mechanical level and the inactive environment regions at lower levels of accuracy, while at

  16. Parallel Simulation of the Shallow Water Equations on Structured Dynamically Adaptive Triangular Grids.

    OpenAIRE

    Vigh, Csaba Attila

    2013-01-01

    One of the most important computational challenges in the context of the numerical treatment of Partial Differential Equations is the generation, management, and dynamic adaptivity of grids. Dynamic adaptivity is extremely important in applications that require frequent changes of the grid pattern during a simulation run. One such application example is Tsunami simulation, where waves have to be tracked with highly resolved local grids. Arbitrary unstructured grids that can ...

  17. Computer simulation program is adaptable to industrial processes

    Science.gov (United States)

    Schultz, F. E.

    1966-01-01

    The Reaction kinetics ablation program /REKAP/, developed to simulate ablation of various materials, provides mathematical formulations for computer programs which can simulate certain industrial processes. The programs are based on the use of nonsymmetrical difference equations that are employed to solve complex partial differential equation systems.

  18. The New England Climate Adaptation Project: Enhancing Local Readiness to Adapt to Climate Change through Role-Play Simulations

    Science.gov (United States)

    Rumore, D.; Kirshen, P. H.; Susskind, L.

    2014-12-01

    Despite scientific consensus that the climate is changing, local efforts to prepare for and manage climate change risks remain limited. How we can raise concern about climate change risks and enhance local readiness to adapt to climate change's effects? In this presentation, we will share the lessons learned from the New England Climate Adaptation Project (NECAP), a participatory action research project that tested science-based role-play simulations as a tool for educating the public about climate change risks and simulating collective risk management efforts. NECAP was a 2-year effort involving the Massachusetts Institute of Technology, the Consensus Building Institute, the National Estuarine Research Reserve System, and four coastal New England municipalities. During 2012-2013, the NECAP team produced downscaled climate change projections, a summary risk assessment, and a stakeholder assessment for each partner community. Working with local partners, we used these assessments to create a tailored, science-based role-play simulation for each site. Through a series of workshops in 2013, NECAP engaged between 115-170 diverse stakeholders and members of the public in each partner municipality in playing the simulation and a follow up conversation about local climate change risks and possible adaptation strategies. Data were collected through before-and-after surveys administered to all workshop participants, follow-up interviews with 25 percent of workshop participants, public opinion polls conducted before and after our intervention, and meetings with public officials. This presentation will report our research findings and explain how science-based role-play simulations can be used to help communicate local climate change risks and enhance local readiness to adapt.

  19. A Simulation Model for the Waterfall Software Development Life Cycle

    CERN Document Server

    Bassil, Youssef

    2012-01-01

    Software development life cycle or SDLC for short is a methodology for designing, building, and maintaining information and industrial systems. So far, there exist many SDLC models, one of which is the Waterfall model which comprises five phases to be completed sequentially in order to develop a software solution. However, SDLC of software systems has always encountered problems and limitations that resulted in significant budget overruns, late or suspended deliveries, and dissatisfied clients. The major reason for these deficiencies is that project directors are not wisely assigning the required number of workers and resources on the various activities of the SDLC. Consequently, some SDLC phases with insufficient resources may be delayed; while, others with excess resources may be idled, leading to a bottleneck between the arrival and delivery of projects and to a failure in delivering an operational product on time and within budget. This paper proposes a simulation model for the Waterfall development proce...

  20. Enzo+Moray: Radiation Hydrodynamics Adaptive Mesh Refinement Simulations with Adaptive Ray Tracing

    CERN Document Server

    Wise, John H

    2010-01-01

    We describe a photon-conserving radiative transfer algorithm, using a spatially-adaptive ray tracing scheme, and its parallel implementation into the adaptive mesh refinement (AMR) cosmological hydrodynamics code, Enzo. By coupling the solver with the energy equation and non-equilibrium chemistry network, our radiation hydrodynamics framework can be utilised to study a broad range of astrophysical problems, such as stellar and black hole (BH) feedback. Inaccuracies can arise from large timesteps and poor sampling, therefore we devised an adaptive time-stepping scheme and a fast approximation of the optically-thin radiation field with multiple sources. We test the method with several radiative transfer and radiation hydrodynamics tests that are given in Iliev et al. (2006, 2009). We further test our method with more dynamical situations, for example, the propagation of an ionisation front through a Rayleigh-Taylor instability, time-varying luminosities, and collimated radiation. The test suite also includes an...

  1. Life on the edge: Vulnerability and adaptation of African ecosystems to global climate change

    OpenAIRE

    Dixon, R; J. Smith; Guill, S.

    2003-01-01

    Donor countries are providing financial and technical support for global climate change country studies to help African nations meet their reporting needs under the United Nations Framework Convention on Climate Change (UNFCCC). Technical assistance to complete vulnerability and adaptation assessments includes training of analysts, sharing of contemporary tools (e.g. simulation models), data and assessment techniques, information-sharing workshops and an international exchange programme for a...

  2. Cross-cultural adaptation of the Quality of Life Index Spinal Cord Injury - Version III

    Directory of Open Access Journals (Sweden)

    Priscila Alencar Mendes Reis

    2015-06-01

    Full Text Available OBJECTIVE To translate and culturally adapt to Portuguese the Ferrans and Powers Quality of Life Index Spinal Cord Injury - Version III and characterize the sample in relation to sociodemographic and clinical aspects. METHOD A methodological study with view to cross-cultural adaptation, following the particular steps of this method: initial translation, translation synthesis, back-translation (translation back to the original language, review by a committee of judges and pretest of the final version. The pretest was carried out with 30 patients with spinal cord injury. RESULTS An index of 74 items divided into two parts (satisfaction/importance was obtained. The criteria of semantic equivalence were evaluated as very adequate translation, higher than 87%, and vocabulary and were grammar higher than 86%. Idiomatic equivalence was higher than 74%, experimental greater than 78% and conceptual was greater than 70%. CONCLUSION After cross-cultural adaptation, the instrument proved semantic, idiomatic, experimental and conceptual adequacy, in addition to helping the evaluation of the quality of life of people with spinal cord injury.

  3. RISKS FOR FAMILY LIFE OF RUSSIAN RESERVE MILITARY SERVANTS IN THE CONTEXT OF SOCIAL ADAPTATION TO CIVILIAN LIFE

    Directory of Open Access Journals (Sweden)

    Pavel Viktorovich Razov

    2015-01-01

    Full Text Available The article analyzes the risks for family life of military servants transferred into the reserve. The risks are influenced by a number of factors that have common foundations for Russian families in the context of their functional transformation as well as specific foundations depending on the nature of their formation and development within a close socio-professional system. In this regard, it is necessary to provide social and psychological support to the families of transferred to reserve servicemen, for whom preservation of the family and stable family relationships becomes a pressing problem, as well as professional adaptation to the new social conditions. Specificity of military servants’ families is in the fact that they are directly dependent on the state and public policy, what determines the high importance of state regulation in the field of social adaptation of servicemen and their families. The author shows that the specificity of military families is largely due to the conditions of their formation and development, influenced by the close social system, which determines the uncontested acceptance of the values and norms of the system (the military environment by all members of the family.

  4. Fuzzy Backstepping Torque Control Of Passive Torque Simulator With Algebraic Parameters Adaptation

    Science.gov (United States)

    Ullah, Nasim; Wang, Shaoping; Wang, Xingjian

    2015-07-01

    This work presents fuzzy backstepping control techniques applied to the load simulator for good tracking performance in presence of extra torque, and nonlinear friction effects. Assuming that the parameters of the system are uncertain and bounded, Algebraic parameters adaptation algorithm is used to adopt the unknown parameters. The effect of transient fuzzy estimation error on parameters adaptation algorithm is analyzed and the fuzzy estimation error is further compensated using saturation function based adaptive control law working in parallel with the actual system to improve the transient performance of closed loop system. The saturation function based adaptive control term is large in the transient time and settles to an optimal lower value in the steady state for which the closed loop system remains stable. The simulation results verify the validity of the proposed control method applied to the complex aerodynamics passive load simulator.

  5. Comparison of Mesh Adaptivity Schemes in Finite ElementSimulation of Tube Extrusion Process

    Directory of Open Access Journals (Sweden)

    K. K. Pathak

    2008-05-01

    Full Text Available In this study, finite element simulation of tube extrusion process has been carried outconsidering different mesh adaptivity schemes. A comparison of these schemes has been madebased on stress, strain distribution, and load-stroke curves. Based on the finite element results,it is observed that the success of the computer simulation is dependent on the mesh refinementcriteria.

  6. Simulating Computer Adaptive Testing With the Mood and Anxiety Symptom Questionnaire

    NARCIS (Netherlands)

    G. Flens; N. Smits; I. Carlier; A.M. van Hemert; E. de Beurs

    2015-01-01

    In a post hoc simulation study (N = 3,597 psychiatric outpatients), we investigated whether the efficiency of the 90-item Mood and Anxiety Symptom Questionnaire (MASQ) could be improved for assessing clinical subjects with computerized adaptive testing (CAT). A CAT simulation was performed on each o

  7. Further international adaptation and validation of the Rheumatoid Arthritis Quality of Life (RAQoL) questionnaire.

    Science.gov (United States)

    Wilburn, Jeanette; McKenna, Stephen P; Twiss, James; Rouse, Matthew; Korkosz, Mariusz; Jancovic, Roman; Nemec, Petr; Pacheco-Tena, César Francisco; Saraux, Alain; Westhovens, Rene; Durez, Patrick; Martin, Mona; Tammaru, Marika

    2015-04-01

    The Rheumatoid Arthritis Quality of Life (RAQoL) questionnaire was developed directly from rheumatoid arthritis (RA) patients in the United Kingdom and the Netherlands to measure quality of life (QoL). Since then, it has become widely used in clinical studies and trials and has been adapted for use in 24 languages. The objective was to develop and validate 11 additional language versions of the RAQoL in US English, Mexican Spanish, Argentinean Spanish, Belgian French, Belgian Flemish, French, Romanian, Czech, Slovakian, Polish and Russian. The language adaptation and validation required three stages: translation, cognitive debriefing interviews and validation survey. The translation process involved a dual-panel methodology (bilingual panel followed by a lay panel). The validation survey tested the psychometric properties of the new scales and included either the Nottingham Health Profile (NHP) or the Health Assessment Questionnaire (HAQ) as comparators. Internal consistency of the new language versions ranged from 0.90 to 0.97 and test-retest reliability from 0.85 to 0.99. RAQoL scores correlated as expected with the HAQ. Correlations with NHP sections were as expected: highest with energy level, pain and physical mobility and lowest with emotional reactions, sleep disturbance, and social isolation. The adaptations exhibited construct validity in their ability to distinguish subgroups of RA patients varying by perceived disease severity and general health. The new language versions of the RAQoL meet the high psychometric standards of the original UK English version. The new adaptations represent valid and reliable tools for measuring QoL in international clinical trials involving RA patients. PMID:25270915

  8. ENZO+MORAY: radiation hydrodynamics adaptive mesh refinement simulations with adaptive ray tracing

    Science.gov (United States)

    Wise, John H.; Abel, Tom

    2011-07-01

    We describe a photon-conserving radiative transfer algorithm, using a spatially-adaptive ray-tracing scheme, and its parallel implementation into the adaptive mesh refinement cosmological hydrodynamics code ENZO. By coupling the solver with the energy equation and non-equilibrium chemistry network, our radiation hydrodynamics framework can be utilized to study a broad range of astrophysical problems, such as stellar and black hole feedback. Inaccuracies can arise from large time-steps and poor sampling; therefore, we devised an adaptive time-stepping scheme and a fast approximation of the optically-thin radiation field with multiple sources. We test the method with several radiative transfer and radiation hydrodynamics tests that are given in Iliev et al. We further test our method with more dynamical situations, for example, the propagation of an ionization front through a Rayleigh-Taylor instability, time-varying luminosities and collimated radiation. The test suite also includes an expanding H II region in a magnetized medium, utilizing the newly implemented magnetohydrodynamics module in ENZO. This method linearly scales with the number of point sources and number of grid cells. Our implementation is scalable to 512 processors on distributed memory machines and can include the radiation pressure and secondary ionizations from X-ray radiation. It is included in the newest public release of ENZO.

  9. Adapt and Cope: Strategies for Safeguarding the Quality of Life in a Shrinking Ageing Region

    Directory of Open Access Journals (Sweden)

    Dr. Annett Steinführer

    2014-06-01

    Full Text Available This article examines the adaptation and coping strategies that are in place to safeguard the quality of life in a shrinking ageing region. In particular, it is investigated which resources are available to local policy-makers and the older population in order to pursue this goal. Following an introduction to the debate of regional science about demographic change and its consequences, we introduce a theoretical differentiation between adaptation and coping. Adaptation strategies refer to the decision-makers who provide or are involved in organising public service facilities. Coping strategies and capacities refer to the customers and users affected by the changes. The population is not only passively affected by changes in public services, but also actively grapples with changed levels of infrastructure and takes up measures to safeguard their own quality of life. Empirically, we employ the results of semi-structured interviews with local and regional key persons and group interviews with elderly inhabitants of two small towns in the Harz region. The region under study is among the most ageing rural areas in Germany. Its demographic characteristics are based on many years of selective out-migration and partially age-selective in-migration. The research results reveal many measures and strategies which have been developed and employed by the different actor groups when faced with tangible problems. However, they have not been planned with a long term perspective. The availability of economic and social resources (human resources and investment funds on the part of administrations, fi nancial resources and social networks on the part of the older population is the chief differentiating and often limiting factor for the success of these measures and strategies. This article comes to the conclusion that adaptation and coping will remain processes for safeguarding the quality of life in shrinking ageing regions for the longer term. In addition to

  10. The transfer of adaptation between actual and simulated rotary stimulation.

    Science.gov (United States)

    Dobie, T G; May, J G; Gutierrez, C; Heller, S S

    1990-12-01

    It is well known that continued exposure to motion environments leads to adaptation, but it is not clear whether such changes are specific to the particular type of motion experienced. The present investigation sought to evaluate the extent of transfer between real motion and visually-induced apparent motion. In addition, the direction of motion was varied and these two factors, mode of exposure and direction of rotation, were examined in a cross-adaptational design. Thirty-two subjects were pre- and posttested on measures of disorientation after active bodily rotation and visually-induced self-vection. Two groups received ten consecutive trials of active bodily rotation (clockwise or counter-clockwise) for 4 consecutive days. Two other groups received ten consecutive trials of visually-induced self-vection (clockwise or counter-clockwise) in a rotating drum for 4 consecutive days. During the exposure phase, dizziness and self-vection increased over trials for the groups exposed to the drum, while dizziness remained unchanged over trials for the groups exposed to bodily rotation. Repeated exposure to bodily rotation resulted in improved walking performance over trials and days. Subjects exposed to bodily rotation exhibited increased tolerance to visually-induced self-vection; however, exposure to visually-induced self-vection did not result in greater tolerance to bodily rotation. No support for directional specificity was evident. PMID:2285397

  11. Adaptive Multiscale Finite Element Method for Subsurface Flow Simulation

    NARCIS (Netherlands)

    Van Esch, J.M.

    2010-01-01

    Natural geological formations generally show multiscale structural and functional heterogeneity evolving over many orders of magnitude in space and time. In subsurface hydrological simulations the geological model focuses on the structural hierarchy of physical sub units and the flow model addresses

  12. Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts.

    Science.gov (United States)

    Ma, Liang; Chen, Zehua; Huang, Da Wei; Kutty, Geetha; Ishihara, Mayumi; Wang, Honghui; Abouelleil, Amr; Bishop, Lisa; Davey, Emma; Deng, Rebecca; Deng, Xilong; Fan, Lin; Fantoni, Giovanna; Fitzgerald, Michael; Gogineni, Emile; Goldberg, Jonathan M; Handley, Grace; Hu, Xiaojun; Huber, Charles; Jiao, Xiaoli; Jones, Kristine; Levin, Joshua Z; Liu, Yueqin; Macdonald, Pendexter; Melnikov, Alexandre; Raley, Castle; Sassi, Monica; Sherman, Brad T; Song, Xiaohong; Sykes, Sean; Tran, Bao; Walsh, Laura; Xia, Yun; Yang, Jun; Young, Sarah; Zeng, Qiandong; Zheng, Xin; Stephens, Robert; Nusbaum, Chad; Birren, Bruce W; Azadi, Parastoo; Lempicki, Richard A; Cuomo, Christina A; Kovacs, Joseph A

    2016-01-01

    Pneumocystis jirovecii is a major cause of life-threatening pneumonia in immunosuppressed patients including transplant recipients and those with HIV/AIDS, yet surprisingly little is known about the biology of this fungal pathogen. Here we report near complete genome assemblies for three Pneumocystis species that infect humans, rats and mice. Pneumocystis genomes are highly compact relative to other fungi, with substantial reductions of ribosomal RNA genes, transporters, transcription factors and many metabolic pathways, but contain expansions of surface proteins, especially a unique and complex surface glycoprotein superfamily, as well as proteases and RNA processing proteins. Unexpectedly, the key fungal cell wall components chitin and outer chain N-mannans are absent, based on genome content and experimental validation. Our findings suggest that Pneumocystis has developed unique mechanisms of adaptation to life exclusively in mammalian hosts, including dependence on the lungs for gas and nutrients and highly efficient strategies to escape both host innate and acquired immune defenses. PMID:26899007

  13. Grappling with Gravity How Will Life Adapt to Living in Space?

    CERN Document Server

    Phillips, Robert W

    2012-01-01

    Grappling with Gravity explores the physiological changes that will occur in humans and the plants and animals that accompany humans as we move to new worlds, whether it be to a colony in the emptiness of space or settlements on the moon, Mars, or other moons or planets. This book focuses on the biomedical aspects, while not ignoring other life-changing influences of space living. For example, what happens to people physiologically in the microgravity of space, where weight and the direction "up" are meaningless? Adapting to microgravity represents the greatest physical challenge that human life will have encountered since our ancestors moved from the seas to solid Earth. It will be the next great adventure!

  14. Genome analysis of three Pneumocystis species reveals adaptation mechanisms to life exclusively in mammalian hosts

    Science.gov (United States)

    Ma, Liang; Chen, Zehua; Huang, Da Wei; Kutty, Geetha; Ishihara, Mayumi; Wang, Honghui; Abouelleil, Amr; Bishop, Lisa; Davey, Emma; Deng, Rebecca; Deng, Xilong; Fan, Lin; Fantoni, Giovanna; Fitzgerald, Michael; Gogineni, Emile; Goldberg, Jonathan M.; Handley, Grace; Hu, Xiaojun; Huber, Charles; Jiao, Xiaoli; Jones, Kristine; Levin, Joshua Z.; Liu, Yueqin; Macdonald, Pendexter; Melnikov, Alexandre; Raley, Castle; Sassi, Monica; Sherman, Brad T.; Song, Xiaohong; Sykes, Sean; Tran, Bao; Walsh, Laura; Xia, Yun; Yang, Jun; Young, Sarah; Zeng, Qiandong; Zheng, Xin; Stephens, Robert; Nusbaum, Chad; Birren, Bruce W.; Azadi, Parastoo; Lempicki, Richard A.; Cuomo, Christina A.; Kovacs, Joseph A.

    2016-01-01

    Pneumocystis jirovecii is a major cause of life-threatening pneumonia in immunosuppressed patients including transplant recipients and those with HIV/AIDS, yet surprisingly little is known about the biology of this fungal pathogen. Here we report near complete genome assemblies for three Pneumocystis species that infect humans, rats and mice. Pneumocystis genomes are highly compact relative to other fungi, with substantial reductions of ribosomal RNA genes, transporters, transcription factors and many metabolic pathways, but contain expansions of surface proteins, especially a unique and complex surface glycoprotein superfamily, as well as proteases and RNA processing proteins. Unexpectedly, the key fungal cell wall components chitin and outer chain N-mannans are absent, based on genome content and experimental validation. Our findings suggest that Pneumocystis has developed unique mechanisms of adaptation to life exclusively in mammalian hosts, including dependence on the lungs for gas and nutrients and highly efficient strategies to escape both host innate and acquired immune defenses. PMID:26899007

  15. Intelligent Electric Power Systems with Active-Adaptive Electric Networks: Challenges for Simulation Tools

    Directory of Open Access Journals (Sweden)

    Ufa Ruslan A.

    2015-01-01

    Full Text Available The motivation of the presented research is based on the needs for development of new methods and tools for adequate simulation of intelligent electric power systems with active-adaptive electric networks (IES including Flexible Alternating Current Transmission System (FACTS devices. The key requirements for the simulation were formed. The presented analysis of simulation results of IES confirms the need to use a hybrid modelling approach.

  16. Block-Structured Adaptive Mesh Refinement Algorithms for Vlasov Simulation

    CERN Document Server

    Hittinger, J A F

    2012-01-01

    Direct discretization of continuum kinetic equations, like the Vlasov equation, are under-utilized because the distribution function generally exists in a high-dimensional (>3D) space and computational cost increases geometrically with dimension. We propose to use high-order finite-volume techniques with block-structured adaptive mesh refinement (AMR) to reduce the computational cost. The primary complication comes from a solution state comprised of variables of different dimensions. We develop the algorithms required to extend standard single-dimension block structured AMR to the multi-dimension case. Specifically, algorithms for reduction and injection operations that transfer data between mesh hierarchies of different dimensions are explained in detail. In addition, modifications to the basic AMR algorithm that enable the use of high-order spatial and temporal discretizations are discussed. Preliminary results for a standard 1D+1V Vlasov-Poisson test problem are presented. Results indicate that there is po...

  17. Adaptive Use of Information during Growth Can Explain Long-Term Effects of Early Life Experiences.

    Science.gov (United States)

    English, Sinead; Fawcett, Tim W; Higginson, Andrew D; Trimmer, Pete C; Uller, Tobias

    2016-05-01

    Development is a continuous process during which individuals gain information about their environment and adjust their phenotype accordingly. In many natural systems, individuals are particularly sensitive to early life experiences, even in the absence of later constraints on plasticity. Recent models have highlighted how the adaptive use of information can explain age-dependent plasticity. These models assume that information gain and phenotypic adjustments either cannot occur simultaneously or are completely independent. This assumption is not valid in the context of growth, where finding food results both in a size increase and learning about food availability. Here, we describe a simple model of growth to provide proof of principle that long-term effects of early life experiences can arise through the coupled dynamics of information acquisition and phenotypic change in the absence of direct constraints on plasticity. The increase in reproductive value from gaining information and sensitivity of behavior to experiences declines across development. Early life experiences have long-term impacts on age of maturity, yet-due to compensatory changes in behavior-our model predicts no substantial effects on reproductive success. We discuss how the evolution of sensitive windows can be explained by experiences having short-term effects on informational and phenotypic states, which generate long-term effects on life-history decisions. PMID:27104994

  18. Energetic costs, underlying resource allocation patterns, and adaptive value of predator-induced life-history shifts

    NARCIS (Netherlands)

    Rinke, K.; Hülsmann, S.; Mooij, W.M.

    2008-01-01

    We studied costs and benefits of life history shifts of water fleas (genus Daphnia) in response to infochemicals from planktivorous fish. We applied a dynamic energy budget model to investigate the resource allocation patterns underlying the observed life history shifts and their adaptive value unde

  19. The Cultural Adaptation Process of Agricultural and Life Sciences Students on Short-Term Study Abroad Experiences

    Science.gov (United States)

    Conner, Nathan William

    2013-01-01

    The purpose of this study was to explore how undergraduate students in a college of agricultural and life sciences experienced cultural adaptation during short-term study abroad programs. The specific objectives of this study were to describe how undergraduate students in the college of agricultural and life sciences experienced culture throughout…

  20. Life History Variation in an Alpine Caddisfly: Local Adaptation or Phenotypic Plasticity?

    Science.gov (United States)

    Shama, L. N.; Robinson, C. T.

    2005-05-01

    Facultative species that inhabit permanent and temporary streams can be locally adapted to their stream of origin or exhibit life history plasticity. Temporary stream populations should respond to environmental cues signalling stream drying, whereas permanent stream populations may not. We used a common garden experiment to test whether males and females of an alpine caddisfly from six populations (3 permanent/3 temporary streams) differed in their life history responses to combined changes in photoperiod (ambient/late) and hydroperiod (constant/drying). Responses varied by sex, time-constraint cue and population. Both sexes shortened development time in the late photoperiod, and males emerged before females in all treatments. Growth rates were higher in the late photoperiod for both sexes, and females had higher growth rates and mass at emergence than males. Growth rate compensation in the late photoperiod resulted in similar masses at emergence for both photoperiods. Population-level differences in responses varied according to microgeographic co-gradient variation. Our results suggest that while stream drying cues may not exert sufficient selection pressure to promote faster development in temporary streams, populations may be locally adapted to differences in growing season length associated with stream-specific environmental characteristics.

  1. The numerical simulation tool for the MAORY multiconjugate adaptive optics system

    CERN Document Server

    Arcidiacono, Carmelo; Bregoli, Giovanni; Diolaiti, Emiliano; Foppiani, Italo; Agapito, Guido; Puglisi, Alfio; Xompero, Marco; Oberti, Sylvain; Cosentino, Giuseppe; Lombini, Matteo; Butler, Chris R; Ciliegi, Paolo; Cortecchia, Fausto; Patti, Mauro; Esposito, Simone; Feautrier, Philippe

    2016-01-01

    The Multiconjugate Adaptive Optics RelaY (MAORY) is and Adaptive Optics module to be mounted on the ESO European-Extremely Large Telescope (E-ELT). It is a hybrid Natural and Laser Guide System that will perform the correction of the atmospheric turbulence volume above the telescope feeding the Multi-AO Imaging Camera for Deep Observations Near Infrared spectro-imager (MICADO). We developed an end-to-end Monte- Carlo adaptive optics simulation tool to investigate the performance of a the MAORY and the calibration, acquisition, operation strategies. MAORY will implement Multiconjugate Adaptive Optics combining Laser Guide Stars (LGS) and Natural Guide Stars (NGS) measurements. The simulation tool implements the various aspect of the MAORY in an end to end fashion. The code has been developed using IDL and uses libraries in C++ and CUDA for efficiency improvements. Here we recall the code architecture, we describe the modeled instrument components and the control strategies implemented in the code.

  2. Whole genome sequencing of turbot (Scophthalmus maximus; Pleuronectiformes): a fish adapted to demersal life

    Science.gov (United States)

    Figueras, Antonio; Robledo, Diego; Corvelo, André; Hermida, Miguel; Pereiro, Patricia; Rubiolo, Juan A.; Gómez-Garrido, Jèssica; Carreté, Laia; Bello, Xabier; Gut, Marta; Gut, Ivo Glynne; Marcet-Houben, Marina; Forn-Cuní, Gabriel; Galán, Beatriz; García, José Luis; Abal-Fabeiro, José Luis; Pardo, Belen G.; Taboada, Xoana; Fernández, Carlos; Vlasova, Anna; Hermoso-Pulido, Antonio; Guigó, Roderic; Álvarez-Dios, José Antonio; Gómez-Tato, Antonio; Viñas, Ana; Maside, Xulio; Gabaldón, Toni; Novoa, Beatriz; Bouza, Carmen; Alioto, Tyler; Martínez, Paulino

    2016-01-01

    The turbot is a flatfish (Pleuronectiformes) with increasing commercial value, which has prompted active genomic research aimed at more efficient selection. Here we present the sequence and annotation of the turbot genome, which represents a milestone for both boosting breeding programmes and ascertaining the origin and diversification of flatfish. We compare the turbot genome with model fish genomes to investigate teleost chromosome evolution. We observe a conserved macrosyntenic pattern within Percomorpha and identify large syntenic blocks within the turbot genome related to the teleost genome duplication. We identify gene family expansions and positive selection of genes associated with vision and metabolism of membrane lipids, which suggests adaptation to demersal lifestyle and to cold temperatures, respectively. Our data indicate a quick evolution and diversification of flatfish to adapt to benthic life and provide clues for understanding their controversial origin. Moreover, we investigate the genomic architecture of growth, sex determination and disease resistance, key traits for understanding local adaptation and boosting turbot production, by mapping candidate genes and previously reported quantitative trait loci. The genomic architecture of these productive traits has allowed the identification of candidate genes and enriched pathways that may represent useful information for future marker-assisted selection in turbot. PMID:26951068

  3. Whole genome sequencing of turbot (Scophthalmus maximus; Pleuronectiformes): a fish adapted to demersal life.

    Science.gov (United States)

    Figueras, Antonio; Robledo, Diego; Corvelo, André; Hermida, Miguel; Pereiro, Patricia; Rubiolo, Juan A; Gómez-Garrido, Jèssica; Carreté, Laia; Bello, Xabier; Gut, Marta; Gut, Ivo Glynne; Marcet-Houben, Marina; Forn-Cuní, Gabriel; Galán, Beatriz; García, José Luis; Abal-Fabeiro, José Luis; Pardo, Belen G; Taboada, Xoana; Fernández, Carlos; Vlasova, Anna; Hermoso-Pulido, Antonio; Guigó, Roderic; Álvarez-Dios, José Antonio; Gómez-Tato, Antonio; Viñas, Ana; Maside, Xulio; Gabaldón, Toni; Novoa, Beatriz; Bouza, Carmen; Alioto, Tyler; Martínez, Paulino

    2016-06-01

    The turbot is a flatfish (Pleuronectiformes) with increasing commercial value, which has prompted active genomic research aimed at more efficient selection. Here we present the sequence and annotation of the turbot genome, which represents a milestone for both boosting breeding programmes and ascertaining the origin and diversification of flatfish. We compare the turbot genome with model fish genomes to investigate teleost chromosome evolution. We observe a conserved macrosyntenic pattern within Percomorpha and identify large syntenic blocks within the turbot genome related to the teleost genome duplication. We identify gene family expansions and positive selection of genes associated with vision and metabolism of membrane lipids, which suggests adaptation to demersal lifestyle and to cold temperatures, respectively. Our data indicate a quick evolution and diversification of flatfish to adapt to benthic life and provide clues for understanding their controversial origin. Moreover, we investigate the genomic architecture of growth, sex determination and disease resistance, key traits for understanding local adaptation and boosting turbot production, by mapping candidate genes and previously reported quantitative trait loci. The genomic architecture of these productive traits has allowed the identification of candidate genes and enriched pathways that may represent useful information for future marker-assisted selection in turbot. PMID:26951068

  4. Testing Set-Point Theory in a Swiss National Sample: Reaction and Adaptation to Major Life Events.

    Science.gov (United States)

    Anusic, Ivana; Yap, Stevie C Y; Lucas, Richard E

    2014-12-01

    Set-point theory posits that individuals react to the experience of major life events, but quickly adapt back to pre-event baseline levels of subjective well-being in the years following the event. A large, nationally representative panel study of Swiss households was used to examine set-point theory by investigating the extent of adaptation following the experience of marriage, childbirth, widowhood, unemployment, and disability. Our results demonstrate that major life events are associated with marked change in life satisfaction and, for some events (e.g., marriage, disability), these changes are relatively long lasting even when accounting for normative, age related change.

  5. Cluster Optimization and Parallelization of Simulations with Dynamically Adaptive Grids

    KAUST Repository

    Schreiber, Martin

    2013-01-01

    The present paper studies solvers for partial differential equations that work on dynamically adaptive grids stemming from spacetrees. Due to the underlying tree formalism, such grids efficiently can be decomposed into connected grid regions (clusters) on-the-fly. A graph on those clusters classified according to their grid invariancy, workload, multi-core affinity, and further meta data represents the inter-cluster communication. While stationary clusters already can be handled more efficiently than their dynamic counterparts, we propose to treat them as atomic grid entities and introduce a skip mechanism that allows the grid traversal to omit those regions completely. The communication graph ensures that the cluster data nevertheless are kept consistent, and several shared memory parallelization strategies are feasible. A hyperbolic benchmark that has to remesh selected mesh regions iteratively to preserve conforming tessellations acts as benchmark for the present work. We discuss runtime improvements resulting from the skip mechanism and the implications on shared memory performance and load balancing. © 2013 Springer-Verlag.

  6. Computerized adaptive testing of population psychological distress:simulation-based evaluation of GHQ-30

    OpenAIRE

    Stochl, Jan; Böhnke, Jan R.; Pickett, Kate E.; Croudace, Tim J.

    2015-01-01

    PURPOSE: Goldberg's General Health Questionnaire (GHQ) items are frequently used to assess psychological distress but no study to date has investigated the GHQ-30's potential for adaptive administration. In computerized adaptive testing (CAT) items are matched optimally to the targeted distress level of respondents instead of relying on fixed-length versions of instruments. We therefore calibrate GHQ-30 items and report a simulation study exploring the potential of this instrument for adaptiv...

  7. Role-play simulations for climate change adaptation education and engagement

    Science.gov (United States)

    Rumore, Danya; Schenk, Todd; Susskind, Lawrence

    2016-08-01

    In order to effectively adapt to climate change, public officials and other stakeholders need to rapidly enhance their understanding of local risks and their ability to collaboratively and adaptively respond to them. We argue that science-based role-play simulation exercises -- a type of 'serious game' involving face-to-face mock decision-making -- have considerable potential as education and engagement tools for enhancing readiness to adapt. Prior research suggests role-play simulations and other serious games can foster public learning and encourage collective action in public policy-making contexts. However, the effectiveness of such exercises in the context of climate change adaptation education and engagement has heretofore been underexplored. We share results from two research projects that demonstrate the effectiveness of role-play simulations in cultivating climate change adaptation literacy, enhancing collaborative capacity and facilitating social learning. Based on our findings, we suggest such exercises should be more widely embraced as part of adaptation professionals' education and engagement toolkits.

  8. Multi-level adaptive simulation of transient two-phase flow in heterogeneous porous media

    KAUST Repository

    Chueh, C.C.

    2010-10-01

    An implicit pressure and explicit saturation (IMPES) finite element method (FEM) incorporating a multi-level shock-type adaptive refinement technique is presented and applied to investigate transient two-phase flow in porous media. Local adaptive mesh refinement is implemented seamlessly with state-of-the-art artificial diffusion stabilization allowing simulations that achieve both high resolution and high accuracy. Two benchmark problems, modelling a single crack and a random porous medium, are used to demonstrate the robustness of the method and illustrate the capabilities of the adaptive refinement technique in resolving the saturation field and the complex interaction (transport phenomena) between two fluids in heterogeneous media. © 2010 Elsevier Ltd.

  9. Cosmological Shocks in Adaptive Mesh Refinement Simulations and the Acceleration of Cosmic Rays

    OpenAIRE

    Skillman, Samuel W.; O'Shea, Brian W.; Hallman, Eric J.; Burns, Jack O.; Michael L. Norman

    2008-01-01

    We present new results characterizing cosmological shocks within adaptive mesh refinement N-Body/hydrodynamic simulations that are used to predict non-thermal components of large-scale structure. This represents the first study of shocks using adaptive mesh refinement. We propose a modified algorithm for finding shocks from those used on unigrid simulations that reduces the shock frequency of low Mach number shocks by a factor of ~3. We then apply our new technique to a large, (512 Mpc/h)^3, ...

  10. Adaptive Physiological Response to Perceived Scarcity as a Mechanism of Sensory Modulation of Life Span.

    Science.gov (United States)

    Waterson, Michael J; Chan, Tammy P; Pletcher, Scott D

    2015-09-01

    Chemosensation is a potent modulator of organismal physiology and longevity. In Drosophila, loss of recognition of diverse tastants has significant and bidirectional life-span effects. Recently published results revealed that when flies were unable to taste water, they increased its internal generation, which may have subsequently altered life span. To determine whether similar adaptive responses occur in other contexts, we explored the impact of sensory deficiency of other metabolically important molecules. Trehalose is a major circulating carbohydrate in the fly that is recognized by the gustatory receptor Gr5a. Gr5a mutant flies are short lived, and we found that they specifically increased whole-body and circulating levels of trehalose, but not other carbohydrates, likely through upregulation of de novo synthesis. dILP2 transcript levels were increased in Gr5a mutants, a possible response intended to reduce hypertrehalosemia, and likely a contributing factor to their reduced life span. Together, these data suggest that compensatory physiological responses to perceived environmental scarcity, which are designed to alleviate the ostensive shortage, may be a common outcome of sensory manipulation. We suggest that future investigations into the mechanisms underlying sensory modulation of aging may benefit by focusing on direct or indirect consequences of physiological changes that are designed to correct perceived disparity with the environment. PMID:25878032

  11. Introducing molecular life science students to model building using computer simulations

    NARCIS (Netherlands)

    Aegerter-Wilmsen, T.; Janssen, F.J.J.M.; Kettenis, D.; Sessink, O.; Hartog, R.; Bisseling, T.

    2006-01-01

    Computer simulations can facilitate the building of models of natural phenomena in research, for example in the molecular life sciences. In order to introduce molecular life science students to using computer simulations for model building, a digital case was developed in which students build a mode

  12. An overview of computational simulation methods for composite structures failure and life analysis

    Science.gov (United States)

    Chamis, Christos C.

    1993-01-01

    Three parallel computational simulation methods are being developed at the LeRC Structural Mechanics Branch (SMB) for composite structures failure and life analysis: progressive fracture CODSTRAN; hierarchical methods for high-temperature composites; and probabilistic evaluation. Results to date demonstrate that these methods are effective in simulating composite structures failure/life/reliability.

  13. EVENT-DRIVEN SIMULATION OF INTEGRATE-AND-FIRE MODELS WITH SPIKE-FREQUENCY ADAPTATION

    Institute of Scientific and Technical Information of China (English)

    Lin Xianghong; Zhang Tianwen

    2009-01-01

    The evoked spike discharges of a neuron depend critically on the recent history of its electrical activity. A well-known example is the phenomenon of spike-frequency adaptation that is a commonly observed property of neurons. In this paper, using a leaky integrate-and-fire model that includes an adaptation current, we propose an event-driven strategy to simulate integrate-and-fire models with spike-frequency adaptation. Such approach is more precise than traditional clock-driven numerical integration approach because the timing of spikes is treated exactly. In experiments, using event-driven and clock-driven strategies we simulated the adaptation time course of single neuron and the random network with spike-timing dependent plasticity, the results indicate that (1) the temporal precision of spiking events impacts on neuronal dynamics of single as well as network in the different simulation strategies and (2) the simulation time scales linearly with the total number of spiking events in the event-driven simulation strategies.

  14. Battery Calendar Life Estimator Manual Modeling and Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Jon P. Christophersen; Ira Bloom; Ed Thomas; Vince Battaglia

    2012-10-01

    The Battery Life Estimator (BLE) Manual has been prepared to assist developers in their efforts to estimate the calendar life of advanced batteries for automotive applications. Testing requirements and procedures are defined by the various manuals previously published under the United States Advanced Battery Consortium (USABC). The purpose of this manual is to describe and standardize a method for estimating calendar life based on statistical models and degradation data acquired from typical USABC battery testing.

  15. Battery Life Estimator Manual Linear Modeling and Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Jon P. Christophersen; Ira Bloom; Ed Thomas; Vince Battaglia

    2009-08-01

    The Battery Life Estimator (BLE) Manual has been prepared to assist developers in their efforts to estimate the calendar life of advanced batteries for automotive applications. Testing requirements and procedures are defined by the various manuals previously published under the United States Advanced Battery Consortium (USABC). The purpose of this manual is to describe and standardize a method for estimating calendar life based on statistical models and degradation data acquired from typical USABC battery testing.

  16. Social adaptation and quality of life in reproductive-aged women with epilepsy

    Directory of Open Access Journals (Sweden)

    Diana Viktorovna Dmitrenko

    2015-01-01

    Full Text Available The quality-of-life indicators are integral characteristics of treatment and diagnostic measures in modern epileptology.Objective: to assess the social adaptation and quality of life in reproductive-aged women with epilepsy.Subjects and methods. A sociological survey using the Quality of Life Satisfaction questionnaire and the European Quality of Life-5 Dimensions (EQ-5D was carried out in 352 women living in the Krasnoyarsk Territory.Results. At the time of the study, 21.3% of the patients were unemployed. Disability related to epilepsy was in 13.1% of women, mainly in those with cryptogenic (22.3% and symptomatic (14.4% epilepsy. Most of the women were unsatisfied with their job activity (55.1%, financial status (64.6%, and physical health (65.3%. Mainly the patients with symptomatic epilepsy reported dissatisfaction with their psychological status. The patients had employment problems (12.5%, inability to work in their specialty (12.5% and to get the desired specialty (10.3%, and labor maladaptation (8.8%. There was a preponderance of women with higher education (40.3% and 21.3% continued their studies. Warm family relations and help from relatives and friends (65.4%, hope for their recovery (50.7%, contacts with their friends (30.1%, and plans for future (34.6% were important for the women to control the disease.Conclusions. The findings suggest that family, personal, maternity problems are more important causes of social maladaptation in epileptic women.

  17. The Self-Adaptive Fuzzy PID Controller in Actuator Simulated Loading System

    OpenAIRE

    Chuanhui Zhang; Xiaodong Song

    2013-01-01

    This paper analyzes the structure principle of the actuator simulated loading system with variable stiffness, and establishes the simplified model. What’s more, it also does a research on the application of the self-adaptive tuning of fuzzy PID(Proportion Integration Differentiation) in actuator simulated loading system with variable stiffness. Because the loading system is connected with the steering system by a spring rod, there must be strong coupling. Besides, there are also the parametri...

  18. Dynamically adaptive Lattice Boltzmann simulation of shallow water flows with the Peano framework

    KAUST Repository

    Neumann, Philipp

    2015-09-01

    © 2014 Elsevier Inc. All rights reserved. We present a dynamically adaptive Lattice Boltzmann (LB) implementation for solving the shallow water equations (SWEs). Our implementation extends an existing LB component of the Peano framework. We revise the modular design with respect to the incorporation of new simulation aspects and LB models. The basic SWE-LB implementation is validated in different breaking dam scenarios. We further provide a numerical study on stability of the MRT collision operator used in our simulations.

  19. A widespread chromosomal inversion polymorphism contributes to a major life-history transition, local adaptation, and reproductive isolation.

    Directory of Open Access Journals (Sweden)

    David B Lowry

    Full Text Available The role of chromosomal inversions in adaptation and speciation is controversial. Historically, inversions were thought to contribute to these processes either by directly causing hybrid sterility or by facilitating the maintenance of co-adapted gene complexes. Because inversions suppress recombination when heterozygous, a recently proposed local adaptation mechanism predicts that they will spread if they capture alleles at multiple loci involved in divergent adaptation to contrasting environments. Many empirical studies have found inversion polymorphisms linked to putatively adaptive phenotypes or distributed along environmental clines. However, direct involvement of an inversion in local adaptation and consequent ecological reproductive isolation has not to our knowledge been demonstrated in nature. In this study, we discovered that a chromosomal inversion polymorphism is geographically widespread, and we test the extent to which it contributes to adaptation and reproductive isolation under natural field conditions. Replicated crosses between the prezygotically reproductively isolated annual and perennial ecotypes of the yellow monkeyflower, Mimulus guttatus, revealed that alternative chromosomal inversion arrangements are associated with life-history divergence over thousands of kilometers across North America. The inversion polymorphism affected adaptive flowering time divergence and other morphological traits in all replicated crosses between four pairs of annual and perennial populations. To determine if the inversion contributes to adaptation and reproductive isolation in natural populations, we conducted a novel reciprocal transplant experiment involving outbred lines, where alternative arrangements of the inversion were reciprocally introgressed into the genetic backgrounds of each ecotype. Our results demonstrate for the first time in nature the contribution of an inversion to adaptation, an annual/perennial life-history shift, and

  20. Adaptability test of lettuce to soil-like substrate in bioregenerative life support system

    Science.gov (United States)

    Min, Yan; Liu, Professor Hong; Wenting, Fu

    Plant cultivation using soil-like substrate (SLS) is considered to be a feasible option for building up matter for biological turnover in bioregenerative life support system (BLSS) by many researchers. The characteristics of SLS are different from those of true soil therefore it is very important to study the adaptability of candidate crop to SLS in BLSS. This study was carried out in three successive steps to test the adaptability of lettuce (Lactuca sativa L.) to rice straw SLS in BLSS of China. First, six Chinese specific lettuce cultivars which were selected for Chinese advanced life support system were planted into the same rice straw SLS, which was to determine the more suitable plant cultivar to do the next experiment. The results showed that Sharp Leaf lettuce and Red lettuce were more suitable for SLS than other cultivars. Second, the possibility of increasing the crop yield on the SLS was conducted by changing the soil depth and plant density. Sharp Leaf lettuce and Red lettuce were used into this experiment in order to obtain the highest yield under the smallest soil volume and weight at the same light intensity. Crop edible biomass, crop nutrition content and photosynthetic characteristics were estimated during the experiment. Red lettuce obtained higher biomass and photosynthesis capacity. Lastly, the stability of planting system of lettuce and SLS was evaluated in the closed controlled system. Red lettuce would be the test plant. In this experiment different age lettuce groups would be planted together and gas exchange would be measured. In all of these experiments soil physical and chemical characteristics were also be measured which will be the basal data for further research.

  1. Numerical simulations of internal solitary waves interacting with uniform slopes using an adaptive model

    Science.gov (United States)

    Rickard, Graham; O'Callaghan, Joanne; Popinet, Stéphane

    Two-dimensional, non-linear, Boussinesq, non-hydrostatic simulations of internal solitary waves breaking and running up uniform slopes have been performed using an adaptive, finite volume fluid code "Gerris". It is demonstrated that the Gerris dynamical core performs well in this specific but important geophysical context. The "semi-structured" nature of Gerris is exploited to enhance model resolution along the slope where wave breaking and run-up occur. Comparison with laboratory experiments reveals that the generation of single and multiple turbulent surges ("boluses") as a function of slope angle is consistently reproduced by the model, comparable with observations and previous numerical simulations, suggesting aspects of the dynamical energy transfers are being represented by the model in two dimensions. Adaptivity is used to explore model convergence of the wave breaking dynamics, and it is shown that significant cpu memory and time savings are possible with adaptivity.

  2. The Self-Adaptive Fuzzy PID Controller in Actuator Simulated Loading System

    Directory of Open Access Journals (Sweden)

    Chuanhui Zhang

    2013-05-01

    Full Text Available This paper analyzes the structure principle of the actuator simulated loading system with variable stiffness, and establishes the simplified model. What’s more, it also does a research on the application of the self-adaptive tuning of fuzzy PID(Proportion Integration Differentiation in actuator simulated loading system with variable stiffness. Because the loading system is connected with the steering system by a spring rod, there must be strong coupling. Besides, there are also the parametric variations accompanying with the variations of the stiffness. Based on compensation from the feed-forward control on the disturbance brought by the motion of steering engine, the system performance can be improved by using fuzzy adaptive adjusting PID control to make up the changes of system parameter caused by the changes of the stiffness. By combining the fuzzy control with traditional PID control, fuzzy adaptive PID control is able to choose the parameters more properly.

  3. Simulation Research on Adaptive Control of a Six-degree-of-freedom Material-testing Machine

    Directory of Open Access Journals (Sweden)

    Dan Wang

    2014-02-01

    Full Text Available This paper presents an adaptive controller equipped with a stiffness estimation method for a novel material-testing machine, in order to alleviate the performance depression caused by the stiffness variance of the tested specimen. The dynamic model of the proposed machine is built using the Kane method, and the kinematic model is established with a closed-form solution. The stiffness estimation method is developed based on the recursive least-squares method and the proposed stiffness equivalent matrix. Control performances of the adaptive controller are simulated in detail. The simulation results illustrate that the proposed controller can greatly improve the control performance of the target material-testing machine by online stiffness estimation and adaptive parameter tuning, especially in low-cycle fatigue (LCF and high-cycle fatigue (HCF tests.

  4. 3D Simulation of Flow with Free Surface Based on Adaptive Octree Mesh System

    Institute of Scientific and Technical Information of China (English)

    Li Shaowu; Zhuang Qian; Huang Xiaoyun; Wang Dong

    2015-01-01

    The technique of adaptive tree mesh is an effective way to reduce computational cost through automatic adjustment of cell size according to necessity. In the present study, the 2D numerical N-S solver based on the adaptive quadtree mesh system was extended to a 3D one, in which a spatially adaptive octree mesh system and multiple parti-cle level set method were adopted for the convenience to deal with the air-water-structure multiple-medium coexisting domain. The stretching process of a dumbbell was simulated and the results indicate that the meshes are well adaptable to the free surface. The collapsing process of water column impinging a circle cylinder was simulated and from the results, it can be seen that the processes of fluid splitting and merging are properly simulated. The interaction of sec-ond-order Stokes waves with a square cylinder was simulated and the obtained drag force is consistent with the result by the Morison’s wave force formula with the coefficient values of the stable drag component and the inertial force component being set as 2.54.

  5. Largenet2: an object-oriented programming library for simulating large adaptive networks

    CERN Document Server

    Zschaler, Gerd

    2012-01-01

    The largenet2 C++ library provides an infrastructure for the simulation of large dynamic and adaptive networks with discrete node and link states. The library is released as free software. It is available at http://rincedd.github.com/largenet2. Largenet2 is licensed under the Creative Commons Attribution-NonCommercial 3.0 Unported License.

  6. Transcultural adaptation and validation of the "Adult Eosinophilic Esophagitis Quality of Life Questionnaire" into Spanish

    Directory of Open Access Journals (Sweden)

    Alfredo J. Lucendo

    2014-06-01

    Full Text Available Background: The "Adult Eosinophilic Esophagitis Quality of Life (EoE-QoL-A Questionnaire" was developed in English as a valid, reliable, and disease-specific health-related QoL measure. This research aims to adapt and validate this questionnaire for Spanish-speaking patients. Patients and methods: A multicenter, observational, prospective study was conducted at 8 Spanish hospitals. The cultural adaptation of the original EoE-QoL-A questionnaire was undertaken through a standardized 3-phase procedure: 1. Translation; 2. Retrotranslation; and 3. Pilot study. Patients completed the Hospital Anxiety and Depression Scale (HADS, the Short Form (SF-12, the Brief Illness Perception Questionnaire (BIPQ, and the adapted EoE-QoL-A, with a retest 3 months later. Statistical analysis included construct validity, internal consistency, criterion validity, and reproducibility. Results: One hundred and seventy adult EoE patients (73.5 % male; aged 33.5 ± 11.4-y were included in the study. With regard to internal validity, all Cronbach alpha values were > 0.75. A significant correlation between items assessed in the SF-12, BIPQ and EoE-QoL-A questionnaires (p < 0.001 was observed. Correlations with the HADS were stronger for anxiety than for depression levels. Anxiety related to disease diagnosis and choking were the most affected dimensions; less affected were the dimensions related to eating, social, and emotional development. Intraclass correlation coefficients between the test and retest assessments were acceptable for all questionnaires, with the highest values (0.73-0.84 calculated for the EoE-QoL-A Spanish version. Conclusion: The Spanish version of the EoE-QoL-A is a reliable, valid, and responsive questionnaire. Diagnosis and choking anxiety were the most affected dimensions in the health-related QoL in adult EoE patients.

  7. Adaptive Wavelet Collocation Method for Simulation of Time Dependent Maxwell's Equations

    CERN Document Server

    Li, Haojun; Rieder, Andreas; Freude, Wolfgang

    2012-01-01

    This paper investigates an adaptive wavelet collocation time domain method for the numerical solution of Maxwell's equations. In this method a computational grid is dynamically adapted at each time step by using the wavelet decomposition of the field at that time instant. In the regions where the fields are highly localized, the method assigns more grid points; and in the regions where the fields are sparse, there will be less grid points. On the adapted grid, update schemes with high spatial order and explicit time stepping are formulated. The method has high compression rate, which substantially reduces the computational cost allowing efficient use of computational resources. This adaptive wavelet collocation method is especially suitable for simulation of guided-wave optical devices.

  8. Simulation and Performance Analysis of Adaptive Filtering Algorithms in Noise Cancellation

    CERN Document Server

    Ferdouse, Lilatul; Nipa, Tamanna Haque; Jaigirdar, Fariha Tasmin

    2011-01-01

    Noise problems in signals have gained huge attention due to the need of noise-free output signal in numerous communication systems. The principal of adaptive noise cancellation is to acquire an estimation of the unwanted interfering signal and subtract it from the corrupted signal. Noise cancellation operation is controlled adaptively with the target of achieving improved signal to noise ratio. This paper concentrates upon the analysis of adaptive noise canceller using Recursive Least Square (RLS), Fast Transversal Recursive Least Square (FTRLS) and Gradient Adaptive Lattice (GAL) algorithms. The performance analysis of the algorithms is done based on convergence behavior, convergence time, correlation coefficients and signal to noise ratio. After comparing all the simulated results we observed that GAL performs the best in noise cancellation in terms of Correlation Coefficient, SNR and Convergence Time. RLS, FTRLS and GAL were never evaluated and compared before on their performance in noise cancellation in ...

  9. Quantum Simulations of Nuclei and Nuclear Pasta with the Multi-resolution Adaptive Numerical Environment for Scientific Simulations

    CERN Document Server

    Sagert, I; Fattoyev, F J; Postnikov, S; Horowitz, C J

    2015-01-01

    Neutron star and supernova matter at densities just below the nuclear matter saturation density is expected to form a lattice of exotic shapes. These so-called nuclear pasta phases are caused by Coulomb frustration. Their elastic and transport properties are believed to play an important role for thermal and magnetic field evolution, rotation and oscillation of neutron stars. Furthermore, they can impact neutrino opacities in core-collapse supernovae. In this work, we present proof-of-principle 3D Skyrme Hartree-Fock (SHF) simulations of nuclear pasta with the Multi-resolution ADaptive Numerical Environment for Scientific Simulations (MADNESS). We perform benchmark studies of $^{16} \\mathrm{O}$, $^{208} \\mathrm{Pb}$ and $^{238} \\mathrm{U}$ nuclear ground states and calculate binding energies via 3D SHF simulations. Results are compared with experimentally measured binding energies as well as with theoretically predicted values from an established SHF code. The nuclear pasta simulation is initialized in the so...

  10. Local error estimates for adaptive simulation of the reaction-diffusion master equation via operator splitting

    Science.gov (United States)

    Hellander, Andreas; Lawson, Michael J.; Drawert, Brian; Petzold, Linda

    2014-06-01

    The efficiency of exact simulation methods for the reaction-diffusion master equation (RDME) is severely limited by the large number of diffusion events if the mesh is fine or if diffusion constants are large. Furthermore, inherent properties of exact kinetic-Monte Carlo simulation methods limit the efficiency of parallel implementations. Several approximate and hybrid methods have appeared that enable more efficient simulation of the RDME. A common feature to most of them is that they rely on splitting the system into its reaction and diffusion parts and updating them sequentially over a discrete timestep. This use of operator splitting enables more efficient simulation but it comes at the price of a temporal discretization error that depends on the size of the timestep. So far, existing methods have not attempted to estimate or control this error in a systematic manner. This makes the solvers hard to use for practitioners since they must guess an appropriate timestep. It also makes the solvers potentially less efficient than if the timesteps were adapted to control the error. Here, we derive estimates of the local error and propose a strategy to adaptively select the timestep when the RDME is simulated via a first order operator splitting. While the strategy is general and applicable to a wide range of approximate and hybrid methods, we exemplify it here by extending a previously published approximate method, the diffusive finite-state projection (DFSP) method, to incorporate temporal adaptivity.

  11. Local error estimates for adaptive simulation of the Reaction–Diffusion Master Equation via operator splitting

    Science.gov (United States)

    Hellander, Andreas; Lawson, Michael J; Drawert, Brian; Petzold, Linda

    2015-01-01

    The efficiency of exact simulation methods for the reaction-diffusion master equation (RDME) is severely limited by the large number of diffusion events if the mesh is fine or if diffusion constants are large. Furthermore, inherent properties of exact kinetic-Monte Carlo simulation methods limit the efficiency of parallel implementations. Several approximate and hybrid methods have appeared that enable more efficient simulation of the RDME. A common feature to most of them is that they rely on splitting the system into its reaction and diffusion parts and updating them sequentially over a discrete timestep. This use of operator splitting enables more efficient simulation but it comes at the price of a temporal discretization error that depends on the size of the timestep. So far, existing methods have not attempted to estimate or control this error in a systematic manner. This makes the solvers hard to use for practitioners since they must guess an appropriate timestep. It also makes the solvers potentially less efficient than if the timesteps are adapted to control the error. Here, we derive estimates of the local error and propose a strategy to adaptively select the timestep when the RDME is simulated via a first order operator splitting. While the strategy is general and applicable to a wide range of approximate and hybrid methods, we exemplify it here by extending a previously published approximate method, the Diffusive Finite-State Projection (DFSP) method, to incorporate temporal adaptivity. PMID:26865735

  12. High-Performance Reactive Fluid Flow Simulations Using Adaptive Mesh Refinement on Thousands of Processors

    Science.gov (United States)

    Calder, A. C.; Curtis, B. C.; Dursi, L. J.; Fryxell, B.; Henry, G.; MacNeice, P.; Olson, K.; Ricker, P.; Rosner, R.; Timmes, F. X.; Tufo, H. M.; Truran, J. W.; Zingale, M.

    We present simulations and performance results of nuclear burning fronts in supernovae on the largest domain and at the finest spatial resolution studied to date. These simulations were performed on the Intel ASCI-Red machine at Sandia National Laboratories using FLASH, a code developed at the Center for Astrophysical Thermonuclear Flashes at the University of Chicago. FLASH is a modular, adaptive mesh, parallel simulation code capable of handling compressible, reactive fluid flows in astrophysical environments. FLASH is written primarily in Fortran 90, uses the Message-Passing Interface library for inter-processor communication and portability, and employs the PARAMESH package to manage a block-structured adaptive mesh that places blocks only where the resolution is required and tracks rapidly changing flow features, such as detonation fronts, with ease. We describe the key algorithms and their implementation as well as the optimizations required to achieve sustained performance of 238 GLOPS on 6420 processors of ASCI-Red in 64-bit arithmetic.

  13. Adaptive grids and numerical fluid simulations for scrape-off layer plasmas

    International Nuclear Information System (INIS)

    Magnetic confinement nuclear fusion experiments create plasmas with local temperatures in excess of 100 million Kelvin. In these experiments the scrape-off layer, which is the plasma region in direct contact with the device wall, is of central importance both for the quality of the energy confinement and the wall material lifetime. To study the behaviour of the scrape-off layer, in addition to experiments, numerical simulations are used. This work investigates the use of adaptive discretizations of space and compatible numerical methods for scrape-off layer simulations. The resulting algorithms allow dynamic adaptation of computational grids aligned to the magnetic fields to precisely capture the strongly anisotropic energy and particle transport in the plasma. The methods are applied to the multi-fluid plasma code B2, with the goal of reducing the runtime of simulations and extending the applicability of the code.

  14. Availability simulation software adaptation to the IFMIF accelerator facility RAMI analyses

    International Nuclear Information System (INIS)

    Highlights: • The reason why IFMIF RAMI analyses needs a simulation is explained. • Changes, modifications and software validations done to AvailSim are described. • First IFMIF RAMI results obtained with AvailSim 2.0 are shown. • Implications of AvailSim 2.0 in IFMIF RAMI analyses are evaluated. - Abstract: Several problems were found when using generic reliability tools to perform RAMI (Reliability Availability Maintainability Inspectability) studies for the IFMIF (International Fusion Materials Irradiation Facility) accelerator. A dedicated simulation tool was necessary to model properly the complexity of the accelerator facility. AvailSim, the availability simulation software used for the International Linear Collider (ILC) became an excellent option to fulfill RAMI analyses needs. Nevertheless, this software needed to be adapted and modified to simulate the IFMIF accelerator facility in a useful way for the RAMI analyses in the current design phase. Furthermore, some improvements and new features have been added to the software. This software has become a great tool to simulate the peculiarities of the IFMIF accelerator facility allowing obtaining a realistic availability simulation. Degraded operation simulation and maintenance strategies are the main relevant features. In this paper, the necessity of this software, main modifications to improve it and its adaptation to IFMIF RAMI analysis are described. Moreover, first results obtained with AvailSim 2.0 and a comparison with previous results is shown

  15. Availability simulation software adaptation to the IFMIF accelerator facility RAMI analyses

    Energy Technology Data Exchange (ETDEWEB)

    Bargalló, Enric, E-mail: enric.bargallo-font@upc.edu [Fusion Energy Engineering Laboratory (FEEL), Technical University of Catalonia (UPC) Barcelona-Tech, Barcelona (Spain); Sureda, Pere Joan [Fusion Energy Engineering Laboratory (FEEL), Technical University of Catalonia (UPC) Barcelona-Tech, Barcelona (Spain); Arroyo, Jose Manuel [Laboratorio Nacional de Fusión por Confinamiento Magnético – CIEMAT, Madrid (Spain); Abal, Javier; De Blas, Alfredo; Dies, Javier; Tapia, Carlos [Fusion Energy Engineering Laboratory (FEEL), Technical University of Catalonia (UPC) Barcelona-Tech, Barcelona (Spain); Mollá, Joaquín; Ibarra, Ángel [Laboratorio Nacional de Fusión por Confinamiento Magnético – CIEMAT, Madrid (Spain)

    2014-10-15

    Highlights: • The reason why IFMIF RAMI analyses needs a simulation is explained. • Changes, modifications and software validations done to AvailSim are described. • First IFMIF RAMI results obtained with AvailSim 2.0 are shown. • Implications of AvailSim 2.0 in IFMIF RAMI analyses are evaluated. - Abstract: Several problems were found when using generic reliability tools to perform RAMI (Reliability Availability Maintainability Inspectability) studies for the IFMIF (International Fusion Materials Irradiation Facility) accelerator. A dedicated simulation tool was necessary to model properly the complexity of the accelerator facility. AvailSim, the availability simulation software used for the International Linear Collider (ILC) became an excellent option to fulfill RAMI analyses needs. Nevertheless, this software needed to be adapted and modified to simulate the IFMIF accelerator facility in a useful way for the RAMI analyses in the current design phase. Furthermore, some improvements and new features have been added to the software. This software has become a great tool to simulate the peculiarities of the IFMIF accelerator facility allowing obtaining a realistic availability simulation. Degraded operation simulation and maintenance strategies are the main relevant features. In this paper, the necessity of this software, main modifications to improve it and its adaptation to IFMIF RAMI analysis are described. Moreover, first results obtained with AvailSim 2.0 and a comparison with previous results is shown.

  16. PECULIAR FEATURES CONCERNING 1-ST-YEAR STUDENT ADAPTATION TO LIFE-ACTIVITY AT ENGINEERING HIGHER EDUCATIONAL INSTITUTION

    Directory of Open Access Journals (Sweden)

    V. A. Klimenko

    2008-01-01

    Full Text Available The paper contains an analysis of peculiar features concerning a 1-st-year student adaptation to new conditions of life-activity  on the basis of self-evaluation made by 212 persons.  In order to obtain the data a methodology for diagnostics of social and psychological adaptation developed by K.Rodgers and R.Diamond has been applied with the purpose to study such integral indices as adaptivity, emotional comfort, friendly attitude, internality, tolerance and domination symptom.

  17. Adaptive finite element simulation of flow and transport applications on parallel computers

    Science.gov (United States)

    Kirk, Benjamin Shelton

    The subject of this work is the adaptive finite element simulation of problems arising in flow and transport applications on parallel computers. Of particular interest are new contributions to adaptive mesh refinement (AMR) in this parallel high-performance context, including novel work on data structures, treatment of constraints in a parallel setting, generality and extensibility via object-oriented programming, and the design/implementation of a flexible software framework. This technology and software capability then enables more robust, reliable treatment of multiscale--multiphysics problems and specific studies of fine scale interaction such as those in biological chemotaxis (Chapter 4) and high-speed shock physics for compressible flows (Chapter 5). The work begins by presenting an overview of key concepts and data structures employed in AMR simulations. Of particular interest is how these concepts are applied in the physics-independent software framework which is developed here and is the basis for all the numerical simulations performed in this work. This open-source software framework has been adopted by a number of researchers in the U.S. and abroad for use in a wide range of applications. The dynamic nature of adaptive simulations pose particular issues for efficient implementation on distributed-memory parallel architectures. Communication cost, computational load balance, and memory requirements must all be considered when developing adaptive software for this class of machines. Specific extensions to the adaptive data structures to enable implementation on parallel computers is therefore considered in detail. The libMesh framework for performing adaptive finite element simulations on parallel computers is developed to provide a concrete implementation of the above ideas. This physics-independent framework is applied to two distinct flow and transport applications classes in the subsequent application studies to illustrate the flexibility of the

  18. Spatially adaptive radiation-hydrodynamical simulations of galaxy formation during cosmological reionization

    CERN Document Server

    Pawlik, Andreas H; Vecchia, Claudio Dalla

    2015-01-01

    We present a suite of cosmological radiation-hydrodynamical simulations of the assembly of galaxies driving the reionization of the intergalactic medium (IGM) at z >~ 6. The simulations account for the hydrodynamical feedback from photoionization heating and the explosion of massive stars as supernovae (SNe). Our reference simulation, which was carried out in a box of size 25 comoving Mpc/h using 2 x 512^3 particles, produces a reasonable reionization history and matches the observed UV luminosity function of galaxies. Simulations with different box sizes and resolutions are used to investigate numerical convergence, and simulations in which either SNe or photoionization heating or both are turned off, are used to investigate the role of feedback from star formation. Ionizing radiation is treated using accurate radiative transfer at the high spatially adaptive resolution at which the hydrodynamics is carried out. SN feedback strongly reduces the star formation rates (SFRs) over nearly the full mass range of s...

  19. Adapting the serial Alpgen event generator to simulate LHC collisions on millions of parallel threads

    CERN Document Server

    Childers, J T; LeCompte, T J; Papka, M E; Benjamin, D P

    2015-01-01

    As the LHC moves to higher energies and luminosity, the demand for computing resources increases accordingly and will soon outpace the growth of the Worldwide LHC Computing Grid. To meet this greater demand, event generation Monte Carlo was targeted for adaptation to run on Mira, the supercomputer at the Argonne Leadership Computing Facility. Alpgen is a Monte Carlo event generation application that is used by LHC experiments in the simulation of collisions that take place in the Large Hadron Collider. This paper details the process by which Alpgen was adapted from a single-processor serial-application to a large-scale parallel-application and the performance that was achieved.

  20. Reinforcement learning for adaptive threshold control of restorative brain-computer interfaces: a Bayesian simulation.

    Science.gov (United States)

    Bauer, Robert; Gharabaghi, Alireza

    2015-01-01

    Restorative brain-computer interfaces (BCI) are increasingly used to provide feedback of neuronal states in a bid to normalize pathological brain activity and achieve behavioral gains. However, patients and healthy subjects alike often show a large variability, or even inability, of brain self-regulation for BCI control, known as BCI illiteracy. Although current co-adaptive algorithms are powerful for assistive BCIs, their inherent class switching clashes with the operant conditioning goal of restorative BCIs. Moreover, due to the treatment rationale, the classifier of restorative BCIs usually has a constrained feature space, thus limiting the possibility of classifier adaptation. In this context, we applied a Bayesian model of neurofeedback and reinforcement learning for different threshold selection strategies to study the impact of threshold adaptation of a linear classifier on optimizing restorative BCIs. For each feedback iteration, we first determined the thresholds that result in minimal action entropy and maximal instructional efficiency. We then used the resulting vector for the simulation of continuous threshold adaptation. We could thus show that threshold adaptation can improve reinforcement learning, particularly in cases of BCI illiteracy. Finally, on the basis of information-theory, we provided an explanation for the achieved benefits of adaptive threshold setting. PMID:25729347

  1. Reinforcement learning for adaptive threshold control of restorative brain-computer interfaces: a Bayesian simulation

    Directory of Open Access Journals (Sweden)

    Robert eBauer

    2015-02-01

    Full Text Available Restorative brain-computer interfaces (BCI are increasingly used to provide feedback of neuronal states in a bid to normalize pathological brain activity and achieve behavioral gains. However, patients and healthy subjects alike often show a large variability, or even inability, of brain self-regulation for BCI control, known as BCI illiteracy. Although current co-adaptive algorithms are powerful for assistive BCIs, their inherent class switching clashes with the operant conditioning goal of restorative BCIs. Moreover, due to the treatment rationale, the classifier of restorative BCIs usually has a constrained feature space, thus limiting the possibility of classifier adaptation.In this context, we applied a Bayesian model of neurofeedback and reinforcement learning for different threshold selection strategies to study the impact of threshold adaptation of a linear classifier on optimizing restorative BCIs. For each feedback iteration, we first determined the thresholds that result in minimal action entropy and maximal instructional efficiency. We then used the resulting vector for the simulation of continuous threshold adaptation. We could thus show that threshold adaptation can improve reinforcement learning, particularly in cases of BCI illiteracy. Finally, on the basis of information-theory, we provided an explanation for the achieved benefits of adaptive threshold setting.

  2. Parameter estimation for chaotic systems using a hybrid adaptive cuckoo search with simulated annealing algorithm

    Science.gov (United States)

    Sheng, Zheng; Wang, Jun; Zhou, Shudao; Zhou, Bihua

    2014-03-01

    This paper introduces a novel hybrid optimization algorithm to establish the parameters of chaotic systems. In order to deal with the weaknesses of the traditional cuckoo search algorithm, the proposed adaptive cuckoo search with simulated annealing algorithm is presented, which incorporates the adaptive parameters adjusting operation and the simulated annealing operation in the cuckoo search algorithm. Normally, the parameters of the cuckoo search algorithm are kept constant that may result in decreasing the efficiency of the algorithm. For the purpose of balancing and enhancing the accuracy and convergence rate of the cuckoo search algorithm, the adaptive operation is presented to tune the parameters properly. Besides, the local search capability of cuckoo search algorithm is relatively weak that may decrease the quality of optimization. So the simulated annealing operation is merged into the cuckoo search algorithm to enhance the local search ability and improve the accuracy and reliability of the results. The functionality of the proposed hybrid algorithm is investigated through the Lorenz chaotic system under the noiseless and noise condition, respectively. The numerical results demonstrate that the method can estimate parameters efficiently and accurately in the noiseless and noise condition. Finally, the results are compared with the traditional cuckoo search algorithm, genetic algorithm, and particle swarm optimization algorithm. Simulation results demonstrate the effectiveness and superior performance of the proposed algorithm.

  3. Parameter estimation for chaotic systems using a hybrid adaptive cuckoo search with simulated annealing algorithm

    Energy Technology Data Exchange (ETDEWEB)

    Sheng, Zheng, E-mail: 19994035@sina.com [College of Meteorology and Oceanography, PLA University of Science and Technology, Nanjing 211101 (China); Wang, Jun; Zhou, Bihua [National Defense Key Laboratory on Lightning Protection and Electromagnetic Camouflage, PLA University of Science and Technology, Nanjing 210007 (China); Zhou, Shudao [College of Meteorology and Oceanography, PLA University of Science and Technology, Nanjing 211101 (China); Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters, Nanjing University of Information Science and Technology, Nanjing 210044 (China)

    2014-03-15

    This paper introduces a novel hybrid optimization algorithm to establish the parameters of chaotic systems. In order to deal with the weaknesses of the traditional cuckoo search algorithm, the proposed adaptive cuckoo search with simulated annealing algorithm is presented, which incorporates the adaptive parameters adjusting operation and the simulated annealing operation in the cuckoo search algorithm. Normally, the parameters of the cuckoo search algorithm are kept constant that may result in decreasing the efficiency of the algorithm. For the purpose of balancing and enhancing the accuracy and convergence rate of the cuckoo search algorithm, the adaptive operation is presented to tune the parameters properly. Besides, the local search capability of cuckoo search algorithm is relatively weak that may decrease the quality of optimization. So the simulated annealing operation is merged into the cuckoo search algorithm to enhance the local search ability and improve the accuracy and reliability of the results. The functionality of the proposed hybrid algorithm is investigated through the Lorenz chaotic system under the noiseless and noise condition, respectively. The numerical results demonstrate that the method can estimate parameters efficiently and accurately in the noiseless and noise condition. Finally, the results are compared with the traditional cuckoo search algorithm, genetic algorithm, and particle swarm optimization algorithm. Simulation results demonstrate the effectiveness and superior performance of the proposed algorithm.

  4. Simulation of Old Urban Residential Area Evolution Based on Complex Adaptive System

    Institute of Scientific and Technical Information of China (English)

    YANG Fan; WANG Xiao-ming; HUA Hong

    2009-01-01

    On the basis of complex adaptive system theory,this paper proposed an agent-based model of old urban residential area,in which,residents and providers are the two adaptive agents.The behaviors of residents and providers in this model are trained with back propagation and simulated with Swarm software based on environment-rules-agents interaction.This model simulates the evolution of old urban residential area and analyzes the relations between the evolution and urban management with the background of Chaozhou city.As a result,the following are obtained:(1) Simulation without government intervention indicates the trend of housing ageing,environmental deterioration,economic depression,and social filtering-down in old urban residential area.If the development of old urban residential area is under control of developers in market,whose desire is profit maximization,and factors such as social justice,historic and culture value will be ignored.(2) If the government carries out some policies and measures which will perfectly serve their original aims,simulation reveals that old urban residential area could be adapted to environment and keep sustainable development.This conclusion emphasizes that government must act as initiator and program maker for guiding residents and other providers directly in the development of old urban residential area.

  5. 3D design and electric simulation of a silicon drift detector using a spiral biasing adapter

    Science.gov (United States)

    Li, Yu-yun; Xiong, Bo; Li, Zheng

    2016-09-01

    The detector system of combining a spiral biasing adapter (SBA) with a silicon drift detector (SBA-SDD) is largely different from the traditional silicon drift detector (SDD), including the spiral SDD. It has a spiral biasing adapter of the same design as a traditional spiral SDD and an SDD with concentric rings having the same radius. Compared with the traditional spiral SDD, the SBA-SDD separates the spiral's functions of biasing adapter and the p-n junction definition. In this paper, the SBA-SDD is simulated using a Sentaurus TCAD tool, which is a full 3D device simulation tool. The simulated electric characteristics include electric potential, electric field, electron concentration, and single event effect. Because of the special design of the SBA-SDD, the SBA can generate an optimum drift electric field in the SDD, comparable with the conventional spiral SDD, while the SDD can be designed with concentric rings to reduce surface area. Also the current and heat generated in the SBA are separated from the SDD. To study the single event response, we simulated the induced current caused by incident heavy ions (20 and 50 μm penetration length) with different linear energy transfer (LET). The SBA-SDD can be used just like a conventional SDD, such as X-ray detector for energy spectroscopy and imaging, etc.

  6. Adaptive Flow Simulation of Turbulence in Subject-Specific Abdominal Aortic Aneurysm on Massively Parallel Computers

    Science.gov (United States)

    Sahni, Onkar; Jansen, Kenneth; Shephard, Mark; Taylor, Charles

    2007-11-01

    Flow within the healthy human vascular system is typically laminar but diseased conditions can alter the geometry sufficiently to produce transitional/turbulent flows in regions focal (and immediately downstream) of the diseased section. The mean unsteadiness (pulsatile or respiratory cycle) further complicates the situation making traditional turbulence simulation techniques (e.g., Reynolds-averaged Navier-Stokes simulations (RANSS)) suspect. At the other extreme, direct numerical simulation (DNS) while fully appropriate can lead to large computational expense, particularly when the simulations must be done quickly since they are intended to affect the outcome of a medical treatment (e.g., virtual surgical planning). To produce simulations in a clinically relevant time frame requires; 1) adaptive meshing technique that closely matches the desired local mesh resolution in all three directions to the highly anisotropic physical length scales in the flow, 2) efficient solution algorithms, and 3) excellent scaling on massively parallel computers. In this presentation we will demonstrate results for a subject-specific simulation of an abdominal aortic aneurysm using stabilized finite element method on anisotropically adapted meshes consisting of O(10^8) elements over O(10^4) processors.

  7. Level-by-level artificial viscosity and visualization for MHD simulation with adaptive mesh refinement

    Science.gov (United States)

    Hatori, Tomoharu; Ito, Atsushi M.; Nunami, Masanori; Usui, Hideyuki; Miura, Hideaki

    2016-08-01

    We propose a numerical method to determine the artificial viscosity in magnetohydrodynamics (MHD) simulations with adaptive mesh refinement (AMR) method, where the artificial viscosity is adaptively changed due to the resolution level of the AMR hierarchy. Although the suitable value of the artificial viscosity depends on the governing equations and the model of target problem, it can be determined by von Neumann stability analysis. By means of the new method, "level-by-level artificial viscosity method," MHD simulations of Rayleigh-Taylor instability (RTI) are carried out with the AMR method. The validity of the level-by-level artificial viscosity method is confirmed by the comparison of the linear growth rates of RTI between the AMR simulations and the simple simulations with uniform grid and uniform artificial viscosity whose resolution is the same as that in the highest level of the AMR simulation. Moreover, in the nonlinear phase of RTI, the secondary instability is clearly observed where the hierarchical data structure of AMR calculation is visualized as high resolution region floats up like terraced fields. In the applications of the method to general fluid simulations, the growth of small structures can be sufficiently reproduced, while the divergence of numerical solutions can be suppressed.

  8. The adaptive value of morphological, behavioural and life-history traits in reproductive female wolves.

    Science.gov (United States)

    Stahler, Daniel R; MacNulty, Daniel R; Wayne, Robert K; vonHoldt, Bridgett; Smith, Douglas W

    2013-01-01

    Reproduction in social organisms is shaped by numerous morphological, behavioural and life-history traits such as body size, cooperative breeding and age of reproduction, respectively. Little is known, however, about the relative influence of these different types of traits on reproduction, particularly in the context of environmental conditions that determine their adaptive value. Here, we use 14 years of data from a long-term study of wolves (Canis lupus) in Yellowstone National Park, USA, to evaluate the relative effects of different traits and ecological factors on the reproductive performance (litter size and survival) of breeding females. At the individual level, litter size and survival improved with body mass and declined with age (c. 4-5 years). Grey-coloured females had more surviving pups than black females, which likely contributed to the maintenance of coat colour polymorphism in this system. The effect of pack size on reproductive performance was nonlinear as litter size peaked at eight wolves and then declined, and litter survival increased rapidly up to three wolves, beyond which it increased more gradually. At the population level, litter size and survival decreased with increasing wolf population size and canine distemper outbreaks. The relative influence of these different-level factors on wolf reproductive success followed individual > group > population. Body mass was the primary determinant of litter size, followed by pack size and population size. Body mass was also the main driver of litter survival, followed by pack size and disease. Reproductive gains because of larger body size and cooperative breeding may mitigate reproductive losses because of negative density dependence and disease. These findings highlight the adaptive value of large body size and sociality in promoting individual fitness in stochastic and competitive environments. PMID:23043440

  9. The Development of an ICF-Oriented, Adaptive Physician Assessment Instrument of Mobility, Self-care, and Domestic Life

    Science.gov (United States)

    Farin, Erik; Fleitz, Annette

    2009-01-01

    The objective of this study was development and psychometric testing of an adaptive, International Classification of Functioning, Disability, and Health (ICF)-oriented questionnaire to be processed by the rehabilitation physician that aids in assessing mobility, self-care, and domestic life (Moses-Physician). The intent is to develop a physician…

  10. Using Structural Equation Modeling to Validate Online Game Players' Motivations Relative to Self-Concept and Life Adaptation

    Science.gov (United States)

    Yang, Shu Ching; Huang, Chiao Ling

    2013-01-01

    This study aimed to validate a systematic instrument to measure online players' motivations for playing online games (MPOG) and examine how the interplay of differential motivations impacts young gamers' self-concept and life adaptation. Confirmatory factor analysis determined that a hierarchical model with a two-factor structure of…

  11. Validation Through Simulations of a Cn2 Profiler for the ESO/VLT Adaptive Optics Facility

    CERN Document Server

    Garcia-Rissmann, A; Kolb, J; Louarn, M Le; Madec, P -Y; Neichel, B

    2015-01-01

    The Adaptive Optics Facility (AOF) project envisages transforming one of the VLT units into an adaptive telescope and providing its ESO (European Southern Observatory) second generation instruments with turbulence corrected wavefronts. For MUSE and HAWK-I this correction will be achieved through the GALACSI and GRAAL AO modules working in conjunction with a 1170 actuators Deformable Secondary Mirror (DSM) and the new Laser Guide Star Facility (4LGSF). Multiple wavefront sensors will enable GLAO and LTAO capabilities, whose performance can greatly benefit from a knowledge about the stratification of the turbulence in the atmosphere. This work, totally based on end-to-end simulations, describes the validation tests conducted on a Cn2 profiler adapted for the AOF specifications. Because an absolute profile calibration is strongly dependent on a reliable knowledge of turbulence parameters r0 and L0, the tests presented here refer only to normalized output profiles. Uncertainties in the input parameters inherent t...

  12. Adapt

    Science.gov (United States)

    Bargatze, L. F.

    2015-12-01

    Active Data Archive Product Tracking (ADAPT) is a collection of software routines that permits one to generate XML metadata files to describe and register data products in support of the NASA Heliophysics Virtual Observatory VxO effort. ADAPT is also a philosophy. The ADAPT concept is to use any and all available metadata associated with scientific data to produce XML metadata descriptions in a consistent, uniform, and organized fashion to provide blanket access to the full complement of data stored on a targeted data server. In this poster, we present an application of ADAPT to describe all of the data products that are stored by using the Common Data File (CDF) format served out by the CDAWEB and SPDF data servers hosted at the NASA Goddard Space Flight Center. These data servers are the primary repositories for NASA Heliophysics data. For this purpose, the ADAPT routines have been used to generate data resource descriptions by using an XML schema named Space Physics Archive, Search, and Extract (SPASE). SPASE is the designated standard for documenting Heliophysics data products, as adopted by the Heliophysics Data and Model Consortium. The set of SPASE XML resource descriptions produced by ADAPT includes high-level descriptions of numerical data products, display data products, or catalogs and also includes low-level "Granule" descriptions. A SPASE Granule is effectively a universal access metadata resource; a Granule associates an individual data file (e.g. a CDF file) with a "parent" high-level data resource description, assigns a resource identifier to the file, and lists the corresponding assess URL(s). The CDAWEB and SPDF file systems were queried to provide the input required by the ADAPT software to create an initial set of SPASE metadata resource descriptions. Then, the CDAWEB and SPDF data repositories were queried subsequently on a nightly basis and the CDF file lists were checked for any changes such as the occurrence of new, modified, or deleted

  13. Wavelet-based adaptive numerical simulation of unsteady 3D flow around a bluff body

    Science.gov (United States)

    de Stefano, Giuliano; Vasilyev, Oleg

    2012-11-01

    The unsteady three-dimensional flow past a two-dimensional bluff body is numerically simulated using a wavelet-based method. The body is modeled by exploiting the Brinkman volume-penalization method, which results in modifying the governing equations with the addition of an appropriate forcing term inside the spatial region occupied by the obstacle. The volume-penalized incompressible Navier-Stokes equations are numerically solved by means of the adaptive wavelet collocation method, where the non-uniform spatial grid is dynamically adapted to the flow evolution. The combined approach is successfully applied to the simulation of vortex shedding flow behind a stationary prism with square cross-section. The computation is conducted at transitional Reynolds numbers, where fundamental unstable three-dimensional vortical structures exist, by well-predicting the unsteady forces arising from fluid-structure interaction.

  14. AN ADAPTIVE EFG-FE COUPLING METHOD FOR THE NUMERICAL SIMULATION OF EXTRUSION PROCESSES

    Institute of Scientific and Technical Information of China (English)

    L.C.Liu; X.H.Dong; C.X.Li

    2008-01-01

    An adaptive EFG-FE coupling method is proposed and developed for the numerical simulation of lateral extrusion and forward-backward extrusion. Initially, the simulation has been implemented by using a conventional FE model. During the deforming process, mesh quality is checked at every incremental step. Distorted elements are automatically converted to EFG nodes, whereas, the less distorted elements are reserved. A new algorithm to generate EFG nodes and interface elements is presented. This method is capable of dealing with large deformation and has higher computational efficiency than using an EFG method wholly. Numerical results demonstrate that the adaptive EFG-FE coupling method has reasonable accuracy and is effective for local bulk metal forming such as extrusion processes.

  15. Bringing Reality into Calculus Classrooms: Mathematizing a Real-life Problem Simulated in a Virtual Environment

    Directory of Open Access Journals (Sweden)

    Olga V. Shipulina

    2013-01-01

    Full Text Available The study explores how students, who had completed the AP calculus course, mathematized the optimal navigation real-life problem simulated in the Second Life Virtual Environment. The particular research interest was to investigate whether/how students’ empirical activity in VE influences the way of their mathematizing.

  16. Simulating computer adaptive testing with the Mood and Anxiety Symptom Questionnaire.

    Science.gov (United States)

    Flens, Gerard; Smits, Niels; Carlier, Ingrid; van Hemert, Albert M; de Beurs, Edwin

    2016-08-01

    In a post hoc simulation study (N = 3,597 psychiatric outpatients), we investigated whether the efficiency of the 90-item Mood and Anxiety Symptom Questionnaire (MASQ) could be improved for assessing clinical subjects with computerized adaptive testing (CAT). A CAT simulation was performed on each of the 3 MASQ subscales (Positive Affect, Negative Affect, and Somatic Anxiety). With the CAT simulation's stopping rule set at a high level of measurement precision, the results showed that patients' test administration can be shortened substantially; the mean decrease in items used for the subscales ranged from 56% up to 74%. Furthermore, the predictive utility of the CAT simulations was sufficient for all MASQ scales. The findings reveal that developing a MASQ CAT for clinical subjects is useful as it leads to more efficient measurement without compromising the reliability of the test outcomes. (PsycINFO Database Record

  17. Scale-adaptive simulation of a hot jet in cross flow

    Energy Technology Data Exchange (ETDEWEB)

    Duda, B M; Esteve, M-J [AIRBUS Operations S.A.S., Toulouse (France); Menter, F R; Hansen, T, E-mail: benjamin.duda@airbus.com [ANSYS Germany GmbH, Otterfing (Germany)

    2011-12-22

    The simulation of a hot jet in cross flow is of crucial interest for the aircraft industry as it directly impacts aircraft safety and global performance. Due to the highly transient and turbulent character of this flow, simulation strategies are necessary that resolve at least a part of the turbulence spectrum. The high Reynolds numbers for realistic aircraft applications do not permit the use of pure Large Eddy Simulations as the spatial and temporal resolution requirements for wall bounded flows are prohibitive in an industrial design process. For this reason, the hybrid approach of the Scale-Adaptive Simulation is employed, which retains attached boundary layers in well-established RANS regime and allows the resolution of turbulent fluctuations in areas with sufficient flow instabilities and grid refinement. To evaluate the influence of the underlying numerical grid, three meshing strategies are investigated and the results are validated against experimental data.

  18. Scale-adaptive simulation of a hot jet in cross flow

    Science.gov (United States)

    Duda, B. M.; Menter, F. R.; Hansen, T.; Esteve, M.-J.

    2011-12-01

    The simulation of a hot jet in cross flow is of crucial interest for the aircraft industry as it directly impacts aircraft safety and global performance. Due to the highly transient and turbulent character of this flow, simulation strategies are necessary that resolve at least a part of the turbulence spectrum. The high Reynolds numbers for realistic aircraft applications do not permit the use of pure Large Eddy Simulations as the spatial and temporal resolution requirements for wall bounded flows are prohibitive in an industrial design process. For this reason, the hybrid approach of the Scale-Adaptive Simulation is employed, which retains attached boundary layers in well-established RANS regime and allows the resolution of turbulent fluctuations in areas with sufficient flow instabilities and grid refinement. To evaluate the influence of the underlying numerical grid, three meshing strategies are investigated and the results are validated against experimental data.

  19. Predictive wind turbine simulation with an adaptive lattice Boltzmann method for moving boundaries

    Science.gov (United States)

    Deiterding, Ralf; Wood, Stephen L.

    2016-09-01

    Operating horizontal axis wind turbines create large-scale turbulent wake structures that affect the power output of downwind turbines considerably. The computational prediction of this phenomenon is challenging as efficient low dissipation schemes are necessary that represent the vorticity production by the moving structures accurately and that are able to transport wakes without significant artificial decay over distances of several rotor diameters. We have developed a parallel adaptive lattice Boltzmann method for large eddy simulation of turbulent weakly compressible flows with embedded moving structures that considers these requirements rather naturally and enables first principle simulations of wake-turbine interaction phenomena at reasonable computational costs. The paper describes the employed computational techniques and presents validation simulations for the Mexnext benchmark experiments as well as simulations of the wake propagation in the Scaled Wind Farm Technology (SWIFT) array consisting of three Vestas V27 turbines in triangular arrangement.

  20. Multi-GPU adaptation of a simulator of heart electric activity

    Directory of Open Access Journals (Sweden)

    Víctor M. García

    2013-12-01

    Full Text Available The simulation of the electrical activity of the heart is calculated by solving a large system of ordinary differential equations; this takes an enormous amount of computation time. In recent years graphics processing unit (GPU are being introduced in the field of high performance computing. These powerful computing devices have attracted research groups requiring simulate the electrical activity of the heart. The research group signing this paper has developed a simulator of cardiac electrical activity that runs on a single GPU. This article describes the adaptation and modification of the simulator to run on multiple GPU. The results confirm that the technique significantly reduces the execution time compared to those obtained with a single GPU, and allows the solution of larger problems.

  1. Harmonic amplitude-phase adaptive control and its application in three-axis simulators

    Institute of Scientific and Technical Information of China (English)

    ZHANG Yuan-sheng; YANG Yi-dong

    2005-01-01

    This paper proposes a compensation method for using the Harmonic Amplitude-Phase Adaptive Control(HAPAC) to increase the precision of sinusoidal motion simulators. It also expounds on the HAPAC principle and structural disposition, develops the HAPAC control laws and analyzes the system stability in the HAPAC. A nethod for further improving the precision using online identification of the system' s frequency-response models is presented. The tested data and tracking errors of the simulator demonstrate that the HAPAC makes the sinusoidal motions achieve higher precision than the common classical controls. The HAPAC can also be used in other tracking systems of precision sinusoidal motions.

  2. Aeroacoustic Simulation of Nose Landing Gear on Adaptive Unstructured Grids With FUN3D

    Science.gov (United States)

    Vatsa, Veer N.; Khorrami, Mehdi R.; Park, Michael A.; Lockhard, David P.

    2013-01-01

    Numerical simulations have been performed for a partially-dressed, cavity-closed nose landing gear configuration that was tested in NASA Langley s closed-wall Basic Aerodynamic Research Tunnel (BART) and in the University of Florida's open-jet acoustic facility known as the UFAFF. The unstructured-grid flow solver FUN3D, developed at NASA Langley Research center, is used to compute the unsteady flow field for this configuration. Starting with a coarse grid, a series of successively finer grids were generated using the adaptive gridding methodology available in the FUN3D code. A hybrid Reynolds-averaged Navier-Stokes/large eddy simulation (RANS/LES) turbulence model is used for these computations. Time-averaged and instantaneous solutions obtained on these grids are compared with the measured data. In general, the correlation with the experimental data improves with grid refinement. A similar trend is observed for sound pressure levels obtained by using these CFD solutions as input to a FfowcsWilliams-Hawkings noise propagation code to compute the farfield noise levels. In general, the numerical solutions obtained on adapted grids compare well with the hand-tuned enriched fine grid solutions and experimental data. In addition, the grid adaption strategy discussed here simplifies the grid generation process, and results in improved computational efficiency of CFD simulations.

  3. Friction compensation for low velocity control of hydraulic flight motion simulator: A simple adaptive robust approach

    Institute of Scientific and Technical Information of China (English)

    Yao Jianyong; Jiao Zongxia; Han Songshan

    2013-01-01

    Low-velocity tracking capability is a key performance of flight motion simulator (FMS),which is mainly affected by the nonlinear friction force.Though many compensation schemes with ad hoc friction models have been proposed,this paper deals with low-velocity control without friction model,since it is easy to be implemented in practice.Firstly,a nonlinear model of the FMS middle frame,which is driven by a hydraulic rotary actuator,is built.Noting that in the low velocity region,the unmodeled friction force is mainly characterized by a changing-slowly part,thus a simple adaptive law can be employed to learn this changing-slowly part and compensate it.To guarantee the boundedness of adaptation process,a discontinuous projection is utilized and then a robust scheme is proposed.The controller achieves a prescribed output tracking transient performance and final tracking accuracy in general while obtaining asymptotic output tracking in the absence of modeling errors.In addition,a saturated projection adaptive scheme is proposed to improve the globally learning capability when the velocity becomes large,which might make the previous proposed projection-based adaptive law be unstable.Theoretical and extensive experimental results are obtained to verify the high-performance nature of the proposed adaptive robust control strategy.

  4. On the adaptations to cave life of some different animal groups (first note

    Directory of Open Access Journals (Sweden)

    Emilian Pricop

    2009-12-01

    Full Text Available In this paper we present the major and common adaptations to the cave environment ofdifferent animal groups. The common features are: anophthalmia, depigmentation, apterism in the caseof insects, body shape and ecophysiological adaptations.

  5. Adaptive style and differences in parent and child report of health-related quality of life in children with cancer.

    Science.gov (United States)

    Jurbergs, Nichole; Russell, Kathryn M W; Long, Alanna; Phipps, Sean

    2008-01-01

    The objective of this study was to examine the self-reported health-related quality of life (HRQL) of children with cancer, and the consistency between child and parent reports of child HRQL, as a function of the child's adaptive style. Participants included 199 children with cancer, 108 healthy children, and their parents. Children completed self-report measures of HRQL and adaptive style. Measures of adaptive style were used to categorize children as high anxious, low anxious, defensive high anxious or repressor. Parents completed measures reporting their children's HRQL. Adaptive style was a significant predictor of child-reported HRQL, particularly on the psychosocial scales, with children identified as repressors reporting the best HRQL. Adaptive style was also predictive of discrepancies between parent and child report of child HRQL. Repressor and low anxious children reported better HRQL than did their parents, while high anxious children reported poorer HRQL, regardless of health status. Adaptive style is a significant determinant of self-reported HRQL in children, particularly in psychosocial domains, while health status (i.e. cancer patient vs healthy control) is predictive only of physical health domains. Researchers and clinicians should be aware of the impact of child adaptive style when assessing HRQL outcomes using self- or parent report. PMID:17410520

  6. Altitudinal and climatic associations of seed dormancy and flowering traits evidence adaptation of annual life cycle timing in Arabidopsis thaliana.

    Science.gov (United States)

    Vidigal, Deborah S; Marques, Alexandre C S S; Willems, Leo A J; Buijs, Gonda; Méndez-Vigo, Belén; Hilhorst, Henk W M; Bentsink, Leónie; Picó, F Xavier; Alonso-Blanco, Carlos

    2016-08-01

    The temporal control or timing of the life cycle of annual plants is presumed to provide adaptive strategies to escape harsh environments for survival and reproduction. This is mainly determined by the timing of germination, which is controlled by the level of seed dormancy, and of flowering initiation. However, the environmental factors driving the evolution of plant life cycles remain largely unknown. To address this question we have analysed nine quantitative life history traits, in a native regional collection of 300 wild accessions of Arabidopsis thaliana. Seed dormancy and flowering time were negatively correlated, indicating that these traits have coevolved. In addition, environmental-phenotypic analyses detected strong altitudinal and climatic clines for most life history traits. Overall, accessions showing life cycles with early flowering, small seeds, high seed dormancy and slow germination rate were associated with locations exposed to high temperature, low summer precipitation and high radiation. Furthermore, we analysed the expression level of the positive regulator of seed dormancy DELAY OF GERMINATION 1 (DOG1), finding similar but weaker altitudinal and climatic patterns than seed dormancy. Therefore, DOG1 regulatory mutations are likely to provide a quantitative molecular mechanism for the adaptation of A. thaliana life cycle to altitude and climate. PMID:26991665

  7. Simulation work of fatigue life prediction of rubber automotive components

    Energy Technology Data Exchange (ETDEWEB)

    Samad, M S A [Automotive Engineering Unit, Institute of Advanced Technology, University Putra Malaysia, 43400, UPM Serdang, Selangor (Malaysia); Ali, Aidy, E-mail: aidy@eng.upm.edu.my [Department of Mechanical and Manufacturing Engineering, Faculty of Engineering, Universiti Putra Malaysia, 43400 UPM, Serdang Selangor (Malaysia)

    2010-05-15

    The usage of rubbers has always been so important, especially in automotive industries. Rubbers have a hyper elastic behaviour which is the ability to withstand very large strain without failure. The normal applications for rubbers are used for shock absorption, sound isolation and mounting. In this study, the predictions of fatigue life of an engine mount of rubber automotive components were presented. The finite element analysis was performed to predict the critical part and the strain output were incorporated into fatigue model for prediction. The predicted result shows agreement in term of failure location of rubber mount.

  8. Computer Simulation as a Tool for Analyzing and Optimizing Real-Life Processes

    Directory of Open Access Journals (Sweden)

    Tomáš Domonkos

    2010-06-01

    Full Text Available In some real-life situations, the analysis of complicated systems using standard analytical methods of operational research represents a particularly difficult endeavor, due to the system's complicated structure or the impossibility of reaching a mathematical solution. In cases when we are not able to use the standard methods of operational research, we can use simulation modeling. Sometimes simulation modeling as a tool for supporting practical decision-making offers a possible solution for this problem. The aim of this paper is to characterize briefly the development of discrete-event simulation methodology over the past 50 years on the grounds of the evolution of various simulation programs, describe the essentials of the simulation program tool Simul8 and present, on the basis of a case study, how we can analyze and optimize complicated real-life systems.

  9. Hardware In The Loop Simulator in UAV Rapid Development Life Cycle

    CERN Document Server

    Adiprawita, Widyawardana; Semibiring, Jaka

    2008-01-01

    Field trial is very critical and high risk in autonomous UAV development life cycle. Hardware in the loop (HIL) simulation is a computer simulation that has the ability to simulate UAV flight characteristic, sensor modeling and actuator modeling while communicating in real time with the UAV autopilot hardware. HIL simulation can be used to test the UAV autopilot hardware reliability, test the closed loop performance of the overall system and tuning the control parameter. By rigorous testing in the HIL simulator, the risk in the field trial can be minimized.

  10. Integrating Problem-Based Learning and Simulation: Effects on Student Motivation and Life Skills.

    Science.gov (United States)

    Roh, Young Sook; Kim, Sang Suk

    2015-07-01

    Previous research has suggested that a teaching strategy integrating problem-based learning and simulation may be superior to traditional lecture. The purpose of this study was to assess learner motivation and life skills before and after taking a course involving problem-based learning and simulation. The design used repeated measures with a convenience sample of 83 second-year nursing students who completed the integrated course. Data from a self-administered questionnaire measuring learner motivation and life skills were collected at pretest, post-problem-based learning, and post-simulation time points. Repeated-measures analysis of variance determined that the mean scores for total learner motivation (F=6.62, P=.003), communication (F=8.27, Pmotivation and total life skills significantly increased both from pretest to postsimulation and from post-problem-based learning test to postsimulation test. Subscales of learner motivation and life skills, intrinsic goal orientation, self-efficacy for learning and performance, problem-solving skills, and self-directed learning skills significantly increased both from pretest to postsimulation test and from post-problem-based learning test to post-simulation test. The results demonstrate that an integrating problem-based learning and simulation course elicits significant improvement in learner motivation and life skills. Simulation plus problem-based learning is more effective than problem-based learning alone at increasing intrinsic goal orientation, task value, self-efficacy for learning and performance, problem solving, and self-directed learning.

  11. A highly pleiotropic amino acid polymorphism in the Drosophila insulin receptor contributes to life-history adaptation

    Science.gov (United States)

    Paaby, Annalise B.; Bergland, Alan O.; Behrman, Emily L.; Schmidt, Paul S.

    2016-01-01

    Finding the specific nucleotides that underlie adaptive variation is a major goal in evolutionary biology, but polygenic traits pose a challenge because the complex genotype–phenotype relationship can obscure the effects of individual alleles. However, natural selection working in large wild populations can shift allele frequencies and indicate functional regions of the genome. Previously, we showed that the two most common alleles of a complex amino acid insertion–deletion polymorphism in the Drosophila insulin receptor show independent, parallel clines in frequency across the North American and Australian continents. Here, we report that the cline is stable over at least a five-year period and that the polymorphism also demonstrates temporal shifts in allele frequency concurrent with seasonal change. We tested the alleles for effects on levels of insulin signaling, fecundity, development time, body size, stress tolerance, and life span. We find that the alleles are associated with predictable differences in these traits, consistent with patterns of Drosophila life-history variation across geography that likely reflect adaptation to the heterogeneous climatic environment. These results implicate insulin signaling as a major mediator of life-history adaptation in Drosophila, and suggest that life-history trade-offs can be explained by extensive pleiotropy at a single locus. PMID:25319083

  12. Adaptive Resolution Simulation of Supramolecular Water: The Concurrent Making, Breaking, and Remaking of Water Bundles.

    Science.gov (United States)

    Zavadlav, Julija; Marrink, Siewert J; Praprotnik, Matej

    2016-08-01

    The adaptive resolution scheme (AdResS) is a multiscale molecular dynamics simulation approach that can concurrently couple atomistic (AT) and coarse-grained (CG) resolution regions, i.e., the molecules can freely adapt their resolution according to their current position in the system. Coupling to supramolecular CG models, where several molecules are represented as a single CG bead, is challenging, but it provides higher computational gains and connection to the established MARTINI CG force field. Difficulties that arise from such coupling have been so far bypassed with bundled AT water models, where additional harmonic bonds between oxygen atoms within a given supramolecular water bundle are introduced. While these models simplify the supramolecular coupling, they also cause in certain situations spurious artifacts, such as partial unfolding of biomolecules. In this work, we present a new clustering algorithm SWINGER that can concurrently make, break, and remake water bundles and in conjunction with the AdResS permits the use of original AT water models. We apply our approach to simulate a hybrid SPC/MARTINI water system and show that the essential properties of water are correctly reproduced with respect to the standard monoscale simulations. The developed hybrid water model can be used in biomolecular simulations, where a significant speed up can be obtained without compromising the accuracy of the AT water model. PMID:27409519

  13. Adaptive Resolution Simulation of Supramolecular Water: The Concurrent Making, Breaking, and Remaking of Water Bundles.

    Science.gov (United States)

    Zavadlav, Julija; Marrink, Siewert J; Praprotnik, Matej

    2016-08-01

    The adaptive resolution scheme (AdResS) is a multiscale molecular dynamics simulation approach that can concurrently couple atomistic (AT) and coarse-grained (CG) resolution regions, i.e., the molecules can freely adapt their resolution according to their current position in the system. Coupling to supramolecular CG models, where several molecules are represented as a single CG bead, is challenging, but it provides higher computational gains and connection to the established MARTINI CG force field. Difficulties that arise from such coupling have been so far bypassed with bundled AT water models, where additional harmonic bonds between oxygen atoms within a given supramolecular water bundle are introduced. While these models simplify the supramolecular coupling, they also cause in certain situations spurious artifacts, such as partial unfolding of biomolecules. In this work, we present a new clustering algorithm SWINGER that can concurrently make, break, and remake water bundles and in conjunction with the AdResS permits the use of original AT water models. We apply our approach to simulate a hybrid SPC/MARTINI water system and show that the essential properties of water are correctly reproduced with respect to the standard monoscale simulations. The developed hybrid water model can be used in biomolecular simulations, where a significant speed up can be obtained without compromising the accuracy of the AT water model.

  14. Goal-Oriented Self-Adaptive hp Finite Element Simulation of 3D DC Borehole Resistivity Simulations

    KAUST Repository

    Calo, Victor M.

    2011-05-14

    In this paper we present a goal-oriented self-adaptive hp Finite Element Method (hp-FEM) with shared data structures and a parallel multi-frontal direct solver. The algorithm automatically generates (without any user interaction) a sequence of meshes delivering exponential convergence of a prescribed quantity of interest with respect to the number of degrees of freedom. The sequence of meshes is generated from a given initial mesh, by performing h (breaking elements into smaller elements), p (adjusting polynomial orders of approximation) or hp (both) refinements on the finite elements. The new parallel implementation utilizes a computational mesh shared between multiple processors. All computational algorithms, including automatic hp goal-oriented adaptivity and the solver work fully in parallel. We describe the parallel self-adaptive hp-FEM algorithm with shared computational domain, as well as its efficiency measurements. We apply the methodology described to the three-dimensional simulation of the borehole resistivity measurement of direct current through casing in the presence of invasion.

  15. Validation of a computer-adaptive test to evaluate generic health-related quality of life

    Directory of Open Access Journals (Sweden)

    Zardaín Pilar C

    2010-12-01

    Full Text Available Abstract Background Health Related Quality of Life (HRQoL is a relevant variable in the evaluation of health outcomes. Questionnaires based on Classical Test Theory typically require a large number of items to evaluate HRQoL. Computer Adaptive Testing (CAT can be used to reduce tests length while maintaining and, in some cases, improving accuracy. This study aimed at validating a CAT based on Item Response Theory (IRT for evaluation of generic HRQoL: the CAT-Health instrument. Methods Cross-sectional study of subjects aged over 18 attending Primary Care Centres for any reason. CAT-Health was administered along with the SF-12 Health Survey. Age, gender and a checklist of chronic conditions were also collected. CAT-Health was evaluated considering: 1 feasibility: completion time and test length; 2 content range coverage, Item Exposure Rate (IER and test precision; and 3 construct validity: differences in the CAT-Health scores according to clinical variables and correlations between both questionnaires. Results 396 subjects answered CAT-Health and SF-12, 67.2% females, mean age (SD 48.6 (17.7 years. 36.9% did not report any chronic condition. Median completion time for CAT-Health was 81 seconds (IQ range = 59-118 and it increased with age (p Conclusions Although domain-specific CATs exist for various areas of HRQoL, CAT-Health is one of the first IRT-based CATs designed to evaluate generic HRQoL and it has proven feasible, valid and efficient, when administered to a broad sample of individuals attending primary care settings.

  16. Online body schema adaptation based on internal mental simulation and multisensory feedback

    Directory of Open Access Journals (Sweden)

    Pedro eVicente

    2016-03-01

    Full Text Available In this paper, we describe a novel approach to obtain automatic adaptation of the robot body schema and to improve the robot perceptual and motor skills based on this body knowledge. Predictions obtained through a mental simulation of the body are combined with the real sensory feedback to achieve two objectives simultaneously: body schema adaptation and markerless 6D hand pose estimation. The body schema consists of a computer graphics simulation of the robot, which includes the arm and head kinematics (adapted online during the movements and an appearance model of the hand shape and texture. The mental simulation process generates predictions on how the hand will appear in the robot camera images, based on the body schema and the proprioceptive information (i.e. motor encoders. These predictions are compared to the actual images using Sequential Monte Carlo techniques to feed a particle-based Bayesian estimation method to estimate the parameters of the body schema. The updated body schema will improve the estimates of the 6D hand pose, which is thenused in a closed-loop control scheme (i.e. visual servoing, enabling precise reaching. We report experiments with the iCub humanoid robot that support the validity of our approach. A number of simulations with precise ground-truth were performed to evaluate the estimation capabilities of the proposed framework. Then, we show how the use of high-performance GPU programming and an edge-based algorithm for visual perception allow for real-time implementation in real world scenarios.

  17. A Hamiltonian theory of adaptive resolution simulations of classical and quantum models of nuclei

    Science.gov (United States)

    Kreis, Karsten; Donadio, Davide; Kremer, Kurt; Potestio, Raffaello

    2015-03-01

    Quantum delocalization of atomic nuclei strongly affects the physical properties of low temperature systems, such as superfluid helium. However, also at room temperature nuclear quantum effects can play an important role for molecules composed by light atoms. An accurate modeling of these effects is possible making use of the Path Integral formulation of Quantum Mechanics. In simulations, this numerically expensive description can be restricted to a small region of space, while modeling the remaining atoms as classical particles. In this way the computational resources required can be significantly reduced. In the present talk we demonstrate the derivation of a Hamiltonian formulation for a bottom-up, theoretically solid coupling between a classical model and a Path Integral description of the same system. The coupling between the two models is established with the so-called Hamiltonian Adaptive Resolution Scheme, resulting in a fully adaptive setup in which molecules can freely diffuse across the classical and the Path Integral regions by smoothly switching their description on the fly. Finally, we show the validation of the approach by means of adaptive resolution simulations of low temperature parahydrogen. Graduate School Materials Science in Mainz, Staudinger Weg 9, 55128 Mainz, Germany.

  18. Accelerating Markov chain Monte Carlo simulation by differential evolution with self-adaptive randomized subspace sampling

    Energy Technology Data Exchange (ETDEWEB)

    Vrugt, Jasper A [Los Alamos National Laboratory; Hyman, James M [Los Alamos National Laboratory; Robinson, Bruce A [Los Alamos National Laboratory; Higdon, Dave [Los Alamos National Laboratory; Ter Braak, Cajo J F [NETHERLANDS; Diks, Cees G H [UNIV OF AMSTERDAM

    2008-01-01

    Markov chain Monte Carlo (MCMC) methods have found widespread use in many fields of study to estimate the average properties of complex systems, and for posterior inference in a Bayesian framework. Existing theory and experiments prove convergence of well constructed MCMC schemes to the appropriate limiting distribution under a variety of different conditions. In practice, however this convergence is often observed to be disturbingly slow. This is frequently caused by an inappropriate selection of the proposal distribution used to generate trial moves in the Markov Chain. Here we show that significant improvements to the efficiency of MCMC simulation can be made by using a self-adaptive Differential Evolution learning strategy within a population-based evolutionary framework. This scheme, entitled DiffeRential Evolution Adaptive Metropolis or DREAM, runs multiple different chains simultaneously for global exploration, and automatically tunes the scale and orientation of the proposal distribution in randomized subspaces during the search. Ergodicity of the algorithm is proved, and various examples involving nonlinearity, high-dimensionality, and multimodality show that DREAM is generally superior to other adaptive MCMC sampling approaches. The DREAM scheme significantly enhances the applicability of MCMC simulation to complex, multi-modal search problems.

  19. Selective adaptation in networks of heterogeneous populations: model, simulation, and experiment.

    Directory of Open Access Journals (Sweden)

    Avner Wallach

    2008-02-01

    Full Text Available Biological systems often change their responsiveness when subject to persistent stimulation, a phenomenon termed adaptation. In neural systems, this process is often selective, allowing the system to adapt to one stimulus while preserving its sensitivity to another. In some studies, it has been shown that adaptation to a frequent stimulus increases the system's sensitivity to rare stimuli. These phenomena were explained in previous work as a result of complex interactions between the various subpopulations of the network. A formal description and analysis of neuronal systems, however, is hindered by the network's heterogeneity and by the multitude of processes taking place at different time-scales. Viewing neural networks as populations of interacting elements, we develop a framework that facilitates a formal analysis of complex, structured, heterogeneous networks. The formulation developed is based on an analysis of the availability of activity dependent resources, and their effects on network responsiveness. This approach offers a simple mechanistic explanation for selective adaptation, and leads to several predictions that were corroborated in both computer simulations and in cultures of cortical neurons developing in vitro. The framework is sufficiently general to apply to different biological systems, and was demonstrated in two different cases.

  20. Reinforcement Corrosion: Numerical Simulation and Service Life Prediction

    DEFF Research Database (Denmark)

    Michel, Alexander

    Modelling of deterioration processes in concrete structures plays an increasing role in the design of reinforced concrete structures. Large sums are spent every year to ensure the durability of concrete structures, especially towards reinforcement corrosion. Improved durability provides increased...... for using experimental data available in the literature. Toquantify the impact of temperature on the moisture sorption experimental investigations were undertaken by means of time domain reflectometry (TDR), in which concrete specimens were subjected to varying temperatures. Using TDR measurements...... experimental data and numerical simulations. Inaddition, experimental investigations were carried out to study the impact of load-induced cracks on the risk of reinforcement corrosion. Instrumented rebars, developed in a previous study, were used to assess the potential for initiation of corrosion along...

  1. Neural correlates of adaptive social responses to real-life frustrating situations: a functional MRI study

    OpenAIRE

    Sekiguchi, Atsushi; Sugiura, Motoaki; Yokoyama, Satoru; Sassa, Yuko; HORIE, Kaoru; Sato, Shigeru; Kawashima, Ryuta

    2013-01-01

    Background Frustrating situations are encountered daily, and it is necessary to respond in an adaptive fashion. A psychological definition states that adaptive social behaviors are “self-performing” and “contain a solution.” The present study investigated the neural correlates of adaptive social responses to frustrating situations by assessing the dimension of causal attribution. Based on attribution theory, internal causality refers to one’s aptitudes that cause natural responses in real-lif...

  2. Simulation and analysis of a Truck Model's ride comfort based on fuzzy adaptive control theory

    Institute of Scientific and Technical Information of China (English)

    JIANG Li-biao; WANG Deng-feng; NI Qiang; TAN Wei-ming

    2007-01-01

    This paper tried to analyse and verify the fuzzy adaptive control strategy of electronic control air suspension system for heavy truck. Created the seven-freedoms vehicle suspension model, and the road input model; with Matlab/Simulink toolboxes and modules, built dynamical system simulation model for heavy truck with air suspension, fuzzy adaptive control model, height control model for air spring, and intelligent control and analyse on root mean square value of acceleration of gravity center of the vehicle under excitation of road. Results show that the fuzzy control had less help to the body vibration on the better pavement, but had the better benefit on the bad road, and the vehicle's root mean square value of acceleration of gravity center is less than passive suspension's obviously.

  3. Parallel simulation of multiphase flows using octree adaptivity and the volume-of-fluid method

    Science.gov (United States)

    Agbaglah, Gilou; Delaux, Sébastien; Fuster, Daniel; Hoepffner, Jérôme; Josserand, Christophe; Popinet, Stéphane; Ray, Pascal; Scardovelli, Ruben; Zaleski, Stéphane

    2011-02-01

    We describe computations performed using the Gerris code, an open-source software implementing finite volume solvers on an octree adaptive grid together with a piecewise linear volume of fluid interface tracking method. The parallelisation of Gerris is achieved by domain decomposition. We show examples of the capabilities of Gerris on several types of problems. The impact of a droplet on a layer of the same liquid results in the formation of a thin air layer trapped between the droplet and the liquid layer that the adaptive refinement allows to capture. It is followed by the jetting of a thin corolla emerging from below the impacting droplet. The jet atomisation problem is another extremely challenging computational problem, in which a large number of small scales are generated. Finally we show an example of a turbulent jet computation in an equivalent resolution of 6×1024 cells. The jet simulation is based on the configuration of the Deepwater Horizon oil leak.

  4. Advanced adaptive computational methods for Navier-Stokes simulations in rotorcraft aerodynamics

    Science.gov (United States)

    Stowers, S. T.; Bass, J. M.; Oden, J. T.

    1993-01-01

    A phase 2 research and development effort was conducted in area transonic, compressible, inviscid flows with an ultimate goal of numerically modeling complex flows inherent in advanced helicopter blade designs. The algorithms and methodologies therefore are classified as adaptive methods, which are error estimation techniques for approximating the local numerical error, and automatically refine or unrefine the mesh so as to deliver a given level of accuracy. The result is a scheme which attempts to produce the best possible results with the least number of grid points, degrees of freedom, and operations. These types of schemes automatically locate and resolve shocks, shear layers, and other flow details to an accuracy level specified by the user of the code. The phase 1 work involved a feasibility study of h-adaptive methods for steady viscous flows, with emphasis on accurate simulation of vortex initiation, migration, and interaction. Phase 2 effort focused on extending these algorithms and methodologies to a three-dimensional topology.

  5. An adaptive tau-leaping method for stochastic simulations of reaction-diffusion systems

    Science.gov (United States)

    Padgett, Jill M. A.; Ilie, Silvana

    2016-03-01

    Stochastic modelling is critical for studying many biochemical processes in a cell, in particular when some reacting species have low population numbers. For many such cellular processes the spatial distribution of the molecular species plays a key role. The evolution of spatially heterogeneous biochemical systems with some species in low amounts is accurately described by the mesoscopic model of the Reaction-Diffusion Master Equation. The Inhomogeneous Stochastic Simulation Algorithm provides an exact strategy to numerically solve this model, but it is computationally very expensive on realistic applications. We propose a novel adaptive time-stepping scheme for the tau-leaping method for approximating the solution of the Reaction-Diffusion Master Equation. This technique combines effective strategies for variable time-stepping with path preservation to reduce the computational cost, while maintaining the desired accuracy. The numerical tests on various examples arising in applications show the improved efficiency achieved by the new adaptive method.

  6. Adaptive and Iterative Methods for Simulations of Nanopores with the PNP-Stokes Equations

    CERN Document Server

    Mitscha-Baude, Gregor; Tulzer, Gerhard; Heitzinger, Clemens

    2016-01-01

    We present a 3D finite element solver for the nonlinear Poisson-Nernst-Planck (PNP) equations for electrodiffusion, coupled to the Stokes system of fluid dynamics. The model serves as a building block for the simulation of macromolecule dynamics inside nanopore sensors. We add to existing numerical approaches by deploying goal-oriented adaptive mesh refinement. To reduce the computation overhead of mesh adaptivity, our error estimator uses the much cheaper Poisson-Boltzmann equation as a simplified model, which is justified on heuristic grounds but shown to work well in practice. To address the nonlinearity in the full PNP-Stokes system, three different linearization schemes are proposed and investigated, with two segregated iterative approaches both outperforming a naive application of Newton's method. Numerical experiments are reported on a real-world nanopore sensor geometry. We also investigate two different models for the interaction of target molecules with the nanopore sensor through the PNP-Stokes equ...

  7. Efficient wave function simulations in nonlinear quantum optics using an adaptive coherent state basis

    International Nuclear Information System (INIS)

    Full text: We show that a suitable set of coherent basis states placed on a discrete hexagonal grid can be used to numerically very accurately represent general quantum states in a memory efficient way. Adding an algorithm for dynamic basis adaptation allows highly accurate Quantum Monte Carlo wave function simulations with small basis sets. At the example of the intricate nonlinear dynamics of an optical parametric oscillator around threshold, we demonstrate that this approach yields accurate time dependent solutions with a substantially smaller basis sets than required for a photon number basis. Above threshold the adaptive basis splits into localized subsets allowing efficient representation of bimodal or even more complex phase space distributions and directly yields an intuitive physical picture of the ongoing dynamics. (author)

  8. Improve earthquake hypocenter using adaptive simulated annealing inversion in regional tectonic, volcano tectonic, and geothermal observation

    International Nuclear Information System (INIS)

    Observation of earthquakes is routinely used widely in tectonic activity observation, and also in local scale such as volcano tectonic and geothermal activity observation. It is necessary for determining the location of precise hypocenter which the process involves finding a hypocenter location that has minimum error between the observed and the calculated travel times. When solving this nonlinear inverse problem, simulated annealing inversion method can be applied to such global optimization problems, which the convergence of its solution is independent of the initial model. In this study, we developed own program codeby applying adaptive simulated annealing inversion in Matlab environment. We applied this method to determine earthquake hypocenter using several data cases which are regional tectonic, volcano tectonic, and geothermal field. The travel times were calculated using ray tracing shooting method. We then compared its results with the results using Geiger’s method to analyze its reliability. Our results show hypocenter location has smaller RMS error compared to the Geiger’s result that can be statistically associated with better solution. The hypocenter of earthquakes also well correlated with geological structure in the study area. Werecommend using adaptive simulated annealing inversion to relocate hypocenter location in purpose to get precise and accurate earthquake location

  9. Adaptations to isolated shoulder fatigue during simulated repetitive work. Part I: Fatigue.

    Science.gov (United States)

    Tse, Calvin T F; McDonald, Alison C; Keir, Peter J

    2016-08-01

    Upper extremity muscle fatigue is challenging to identify during industrial tasks and places changing demands on the shoulder complex that are not fully understood. The purpose of this investigation was to examine adaptation strategies in response to isolated anterior deltoid muscle fatigue while performing simulated repetitive work. Participants completed two blocks of simulated repetitive work separated by an anterior deltoid fatigue protocol; the first block had 20 work cycles and the post-fatigue block had 60 cycles. Each work cycle was 60s in duration and included 4 tasks: handle pull, cap rotation, drill press and handle push. Surface EMG of 14 muscles and upper body kinematics were recorded. Immediately following fatigue, glenohumeral flexion strength was reduced, rating of perceived exertion scores increased and signs of muscle fatigue (increased EMG amplitude, decreased EMG frequency) were present in anterior and posterior deltoids, latissimus dorsi and serratus anterior. Along with other kinematic and muscle activity changes, scapular reorientation occurred in all of the simulated tasks and generally served to increase the width of the subacromial space. These findings suggest that immediately following fatigue people adapt by repositioning joints to maintain task performance and may also prioritize maintaining subacromial space width.

  10. Improve earthquake hypocenter using adaptive simulated annealing inversion in regional tectonic, volcano tectonic, and geothermal observation

    Energy Technology Data Exchange (ETDEWEB)

    Ry, Rexha Verdhora, E-mail: rexha.vry@gmail.com [Master Program of Geophysical Engineering, Faculty of Mining and Petroleum Engineering, Institut Teknologi Bandung, Jalan Ganesha No.10, Bandung 40132 (Indonesia); Nugraha, Andri Dian, E-mail: nugraha@gf.itb.ac.id [Global Geophysical Research Group, Faculty of Mining and Petroleum Engineering, Institut Teknologi Bandung, Jalan Ganesha No.10, Bandung 40132 (Indonesia)

    2015-04-24

    Observation of earthquakes is routinely used widely in tectonic activity observation, and also in local scale such as volcano tectonic and geothermal activity observation. It is necessary for determining the location of precise hypocenter which the process involves finding a hypocenter location that has minimum error between the observed and the calculated travel times. When solving this nonlinear inverse problem, simulated annealing inversion method can be applied to such global optimization problems, which the convergence of its solution is independent of the initial model. In this study, we developed own program codeby applying adaptive simulated annealing inversion in Matlab environment. We applied this method to determine earthquake hypocenter using several data cases which are regional tectonic, volcano tectonic, and geothermal field. The travel times were calculated using ray tracing shooting method. We then compared its results with the results using Geiger’s method to analyze its reliability. Our results show hypocenter location has smaller RMS error compared to the Geiger’s result that can be statistically associated with better solution. The hypocenter of earthquakes also well correlated with geological structure in the study area. Werecommend using adaptive simulated annealing inversion to relocate hypocenter location in purpose to get precise and accurate earthquake location.

  11. Adaptations to isolated shoulder fatigue during simulated repetitive work. Part I: Fatigue.

    Science.gov (United States)

    Tse, Calvin T F; McDonald, Alison C; Keir, Peter J

    2016-08-01

    Upper extremity muscle fatigue is challenging to identify during industrial tasks and places changing demands on the shoulder complex that are not fully understood. The purpose of this investigation was to examine adaptation strategies in response to isolated anterior deltoid muscle fatigue while performing simulated repetitive work. Participants completed two blocks of simulated repetitive work separated by an anterior deltoid fatigue protocol; the first block had 20 work cycles and the post-fatigue block had 60 cycles. Each work cycle was 60s in duration and included 4 tasks: handle pull, cap rotation, drill press and handle push. Surface EMG of 14 muscles and upper body kinematics were recorded. Immediately following fatigue, glenohumeral flexion strength was reduced, rating of perceived exertion scores increased and signs of muscle fatigue (increased EMG amplitude, decreased EMG frequency) were present in anterior and posterior deltoids, latissimus dorsi and serratus anterior. Along with other kinematic and muscle activity changes, scapular reorientation occurred in all of the simulated tasks and generally served to increase the width of the subacromial space. These findings suggest that immediately following fatigue people adapt by repositioning joints to maintain task performance and may also prioritize maintaining subacromial space width. PMID:26208429

  12. Brazilian cross-cultural translation and adaptation of the "Questionnaire of Life Quality Specific for Myasthenia Gravis - 15 items"

    OpenAIRE

    Aline Mansueto Mourao; Caroline Martins Araujo; Luiz Sergio Mageste Barbosa; Rodrigo Santiago Gomez; Burns, Ted M.; Stela Maris Aguiar Lemos; Antonio Lucio Teixeira

    2013-01-01

    Objective To translate and to perform the cross-cultural adaptation of the “Questionnaire of Life Quality Specific for Myasthenia Gravis - 15 items” (MG-QOL15). Method The original English version of the questionnaire was translated into Portuguese. This version was revised and translated back into English. Later, both English versions were compared and the divergences were corrected in the Portuguese text. At a second stage, ten patients with MG followed at the Neuromuscular Diseases Clini...

  13. Direct numerical simulations of particle-laden density currents with adaptive, discontinuous finite elements

    Directory of Open Access Journals (Sweden)

    S. D. Parkinson

    2014-09-01

    Full Text Available High-resolution direct numerical simulations (DNSs are an important tool for the detailed analysis of turbidity current dynamics. Models that resolve the vertical structure and turbulence of the flow are typically based upon the Navier–Stokes equations. Two-dimensional simulations are known to produce unrealistic cohesive vortices that are not representative of the real three-dimensional physics. The effect of this phenomena is particularly apparent in the later stages of flow propagation. The ideal solution to this problem is to run the simulation in three dimensions but this is computationally expensive. This paper presents a novel finite-element (FE DNS turbidity current model that has been built within Fluidity, an open source, general purpose, computational fluid dynamics code. The model is validated through re-creation of a lock release density current at a Grashof number of 5 × 106 in two and three dimensions. Validation of the model considers the flow energy budget, sedimentation rate, head speed, wall normal velocity profiles and the final deposit. Conservation of energy in particular is found to be a good metric for measuring model performance in capturing the range of dynamics on a range of meshes. FE models scale well over many thousands of processors and do not impose restrictions on domain shape, but they are computationally expensive. The use of adaptive mesh optimisation is shown to reduce the required element count by approximately two orders of magnitude in comparison with fixed, uniform mesh simulations. This leads to a substantial reduction in computational cost. The computational savings and flexibility afforded by adaptivity along with the flexibility of FE methods make this model well suited to simulating turbidity currents in complex domains.

  14. Simulated annealing method for electronic circuits design: adaptation and comparison with other optimization methods

    International Nuclear Information System (INIS)

    The circuit design problem consists in determining acceptable parameter values (resistors, capacitors, transistors geometries ...) which allow the circuit to meet various user given operational criteria (DC consumption, AC bandwidth, transient times ...). This task is equivalent to a multidimensional and/or multi objective optimization problem: n-variables functions have to be minimized in an hyper-rectangular domain ; equality constraints can be eventually specified. A similar problem consists in fitting component models. In this way, the optimization variables are the model parameters and one aims at minimizing a cost function built on the error between the model response and the data measured on the component. The chosen optimization method for this kind of problem is the simulated annealing method. This method, provided by the combinatorial optimization domain, has been adapted and compared with other global optimization methods for the continuous variables problems. An efficient strategy of variables discretization and a set of complementary stopping criteria have been proposed. The different parameters of the method have been adjusted with analytical functions of which minima are known, classically used in the literature. Our simulated annealing algorithm has been coupled with an open electrical simulator SPICE-PAC of which the modular structure allows the chaining of simulations required by the circuit optimization process. We proposed, for high-dimensional problems, a partitioning technique which ensures proportionality between CPU-time and variables number. To compare our method with others, we have adapted three other methods coming from combinatorial optimization domain - the threshold method, a genetic algorithm and the Tabu search method - The tests have been performed on the same set of test functions and the results allow a first comparison between these methods applied to continuous optimization variables. Finally, our simulated annealing program

  15. Conception d'un environnement virtuel avec adaptation de l'immersion pour la simulation de conduite en fauteuil roulant

    OpenAIRE

    Goncalves, Frédéric

    2014-01-01

    This thesis focuses on the adaptation of the immersion in a driving wheelchair simulation. This is the study of sensory feedback realism involved in a virtual environment in order to adapt the immersion according to user preferences and the task to perform. These works were performed within the AccesSim project supported by the Ile de France region. The project objective is to develop a dynamic simulator to evaluate the accessibility and also urban environment, to conduct training in the use ...

  16. Social Daydreaming and Adjustment: An Experience-Sampling Study of Socio-Emotional Adaptation During a Life Transition.

    Science.gov (United States)

    Poerio, Giulia L; Totterdell, Peter; Emerson, Lisa-Marie; Miles, Eleanor

    2016-01-01

    Estimates suggest that up to half of waking life is spent daydreaming; that is, engaged in thought that is independent of, and unrelated to, one's current task. Emerging research indicates that daydreams are predominately social suggesting that daydreams may serve socio-emotional functions. Here we explore the functional role of social daydreaming for socio-emotional adjustment during an important and stressful life transition (the transition to university) using experience-sampling with 103 participants over 28 days. Over time, social daydreams increased in their positive characteristics and positive emotional outcomes; specifically, participants reported that their daydreams made them feel more socially connected and less lonely, and that the content of their daydreams became less fanciful and involved higher quality relationships. These characteristics then predicted less loneliness at the end of the study, which, in turn was associated with greater social adaptation to university. Feelings of connection resulting from social daydreams were also associated with less emotional inertia in participants who reported being less socially adapted to university. Findings indicate that social daydreaming is functional for promoting socio-emotional adjustment to an important life event. We highlight the need to consider the social content of stimulus-independent cognitions, their characteristics, and patterns of change, to specify how social thoughts enable socio-emotional adaptation.

  17. Adaptations to Hydrothermal Vent Life in Kiwa tyleri, a New Species of Yeti Crab from the East Scotia Ridge, Antarctica.

    Directory of Open Access Journals (Sweden)

    Sven Thatje

    Full Text Available Hydrothermal vents in the Southern Ocean are the physiologically most isolated chemosynthetic environments known. Here, we describe Kiwa tyleri sp. nov., the first species of yeti crab known from the Southern Ocean. Kiwa tyleri belongs to the family Kiwaidae and is the visually dominant macrofauna of two known vent sites situated on the northern and southern segments of the East Scotia Ridge (ESR. The species is known to depend on primary productivity by chemosynthetic bacteria and resides at the warm-eurythermal vent environment for most of its life; its short-range distribution away from vents (few metres is physiologically constrained by the stable, cold waters of the surrounding Southern Ocean. Kiwa tylerihas been shown to present differential life history adaptations in response to this contrasting thermal environment. Morphological adaptations specific to life in warm-eurythermal waters, as found on - or in close proximity of - vent chimneys, are discussed in comparison with adaptations seen in the other two known members of the family (K. hirsuta, K. puravida, which show a preference for low temperature chemosynthetic environments.

  18. Phase-field simulation of dendritic solidification using a full threaded tree with adaptive meshing

    Institute of Scientific and Technical Information of China (English)

    Yin Yajun; Zhou Jianxin; Liao Dunming; Pang Shengyong; Shen Xu

    2014-01-01

    Simulation of the microstructure evolution during solidification is greatly beneficial to the control of solidification microstructures. A phase-field method based on the ful threaded tree (FTT) for the simulation of casting solidification microstructure was proposed in this paper, and the structure of the ful threaded tree and the mesh refinement method was discussed. During dendritic growth in solidification, the mesh for simulation is adaptively refined at the liquid-solid interface, and coarsened in other areas. The numerical results of a three-dimension dendrite growth indicate that the phase-field method based on FTT is suitable for microstructure simulation. Most importantly, the FTT method can increase the spatial and temporal resolutions beyond the limits imposed by the available hardware compared with the conventional uniform mesh. At the simulation time of 0.03 s in this study, the computer memory used for computation is no more than 10 MB with the FTT method, while it is about 50 MB with the uniform mesh method. In addition, the proposed FTT method is more efficient in computation time when compared with the uniform mesh method. It would take about 20 h for the uniform mesh method, while only 2 h for the FTT method for computation when the solidification time is 0.17 s in this study.

  19. Cyberwar XXI: quantifying the unquantifiable: adaptive AI for next-generation conflict simulations

    Science.gov (United States)

    Miranda, Joseph; von Kleinsmid, Peter; Zalewski, Tony

    2004-08-01

    The era of the "Revolution in Military Affairs," "4th Generation Warfare" and "Asymmetric War" requires novel approaches to modeling warfare at the operational and strategic level of modern conflict. For example, "What if, in response to our planned actions, the adversary reacts in such-and-such a manner? What will our response be? What are the possible unintended consequences?" Next generation conflict simulation tools are required to help create and test novel courses of action (COA's) in support of real-world operations. Conflict simulations allow non-lethal and cost-effective exploration of the "what-if" of COA development. The challenge has been to develop an automated decision-support software tool which allows competing COA"s to be compared in simulated dynamic environments. Principal Investigator Joseph Miranda's research is based on modeling an integrated military, economic, social, infrastructure and information (PMESII) environment. The main effort was to develop an adaptive AI engine which models agents operating within an operational-strategic conflict environment. This was implemented in Cyberwar XXI - a simulation which models COA selection in a PMESII environment. Within this framework, agents simulate decision-making processes and provide predictive capability of the potential behavior of Command Entities. The 2003 Iraq is the first scenario ready for V&V testing.

  20. Adaptive Resolution Simulations with Self-Adjusting High-Resolution Regions.

    Science.gov (United States)

    Kreis, Karsten; Potestio, Raffaello; Kremer, Kurt; Fogarty, Aoife C

    2016-08-01

    In adaptive resolution simulations, different regions of a simulation box are modeled with different levels of detail. Particles change their resolution on-the-fly when traveling from one subregion to the other. This method is particularly useful for studying multiscale systems in which effects on a broad range of length and time scales play a role. Until now, the geometry of the high-resolution region has been limited to simple geometries of spherical, cuboid, or cylindrical form, whose shape does not change during the simulation. However, many phenomena involve changes in size and shape of system components, for example, protein folding, polymer collapse, nucleation, and crystallization. In this work, we develop a scheme that uses a series of overlapping spheres to allow for an arbitrary division of space into domains of different levels of resolution. Furthermore, the geometry is automatically adjusted on-the-fly during the simulation according to changes in size and shape of, for example, a solvated macromolecule within the high-resolution region. The proposed approach is validated on liquid water. We then simulate the folding of an atomistically detailed polypeptide solvated in a shell of atomistic water that changes shape as the peptide conformation changes. We demonstrate that the peptide folding process is unperturbed by the use of our methodology. PMID:27384753

  1. The Life of a Dead Ant : The Expression of an Adaptive Extended Phenotype

    NARCIS (Netherlands)

    Andersen, Sandra B.; Gerritsma, Sylvia; Yusah, Kalsum M.; Mayntz, David; Hywel-Jones, Nigel L.; Billen, Johan; Boomsma, Jacobus J.; Hughes, David P.

    2009-01-01

    Specialized parasites are expected to express complex adaptations to their hosts. Manipulation of host behavior is such an adaptation. We studied the fungus Ophiocordyceps unilateralis, a locally specialized parasite of arboreal Camponotus leonardi ants. Ant-infecting Ophiocordyceps are known to mak

  2. Reactively and Anticipatory Behaving Agents for Artificial Life Simulations

    Science.gov (United States)

    Kohout, Karel; Nahodil, Pavel

    2010-11-01

    Reactive behavior is still considered and the exact opposite for the anticipatory one. Despite the advances on the field of anticipation there are little thoughts on relation with the reactive behavior, the similarities and where the boundary is. In this article we will present our viewpoint and we will try to show that reactive and anticipatory behavior can be combined. This is the basic ground of our unified theory for anticipatory behavior architecture. We still miss such compact theory, which would integrate multiple aspects of anticipation. My multi-level anticipatory behavior approach is based on the current understanding of anticipation from both the artificial intelligence and biology point of view. As part of the explanation we will also elaborate on the topic of weak and strong artificial life. Anticipation is not matter of a single mechanism in a living organism. It was noted already that it happens on many different levels even in the very simple creatures. What we consider to be important for our work and what is our original though is that it happens even without voluntary control. We believe that this is novelty though for the anticipation theory. Naturally research of anticipation was in the beginning of this decade focused on the anticipatory principles bringing advances on the field itself. This allowed us to build on those, look at them from higher perspective, and use not one but multiple levels of anticipation in a creature design. This presents second original though and that is composition of the agent architecture that has anticipation built in almost every function. In this article we will focus only on first two levels within the 8-factor anticipation framework. We will introduce them as defined categories of anticipation and describe them from theory and implementation algorithm point of view. We will also present an experiment conducted, however this experiment serves more as explanatory example. These first two levels may seem trivial

  3. Strategy and Simulation of Adaptive RID for Distributed Dynamic Load Balancing in Parallel Systems

    Institute of Scientific and Technical Information of China (English)

    林成江; 李三立

    1997-01-01

    Dynamic load balancing schemes are significant for efficiently executing nonuniform problems in highly parallel multicomputer systems.The objective is to minimize the total exectuion time of single applications.This paper has proposed an ARID strategy for distributed dynamic load balancing.Its principle and control protocol are described,and te communication overhead,the effect on system stability and the performance efficiency are analyzed.Finally,simulation experiments are carried out to compare the adaptive strategy with other dynamic load balancing schemes.

  4. Simulation of a ground-layer adaptive optics system for the Kunlun Dark Universe Survey Telescope

    Institute of Scientific and Technical Information of China (English)

    Peng Jia; Sijiong Zhang

    2013-01-01

    Ground Layer Adaptive Optics (GLAO) is a recently developed technique extensively applied to ground-based telescopes,which mainly compensates for the wavefront errors induced by ground-layer turbulence to get an appropriate point spread function in a wide field of view.The compensation results mainly depend on the turbulence distribution.The atmospheric turbulence at Dome A in the Antarctic is mainly distributed below 15 meters,which is an ideal site for applications of GLAO.The GLAO system has been simulated for the Kunlun Dark Universe Survey Telescope,which will be set up at Dome A,and uses a rotating mirror to generate several laser guide stars and a wavefront sensor with a wide field of view to sequentially measure the wavefronts from different laser guide stars.The system is simulated on a computer and parameters of the system are given,which provide detailed information about the design of a practical GLAO system.

  5. Adaptive MANET Multipath Routing Algorithm Based on the Simulated Annealing Approach

    Directory of Open Access Journals (Sweden)

    Sungwook Kim

    2014-01-01

    Full Text Available Mobile ad hoc network represents a system of wireless mobile nodes that can freely and dynamically self-organize network topologies without any preexisting communication infrastructure. Due to characteristics like temporary topology and absence of centralized authority, routing is one of the major issues in ad hoc networks. In this paper, a new multipath routing scheme is proposed by employing simulated annealing approach. The proposed metaheuristic approach can achieve greater and reciprocal advantages in a hostile dynamic real world network situation. Therefore, the proposed routing scheme is a powerful method for finding an effective solution into the conflict mobile ad hoc network routing problem. Simulation results indicate that the proposed paradigm adapts best to the variation of dynamic network situations. The average remaining energy, network throughput, packet loss probability, and traffic load distribution are improved by about 10%, 10%, 5%, and 10%, respectively, more than the existing schemes.

  6. Accelerating the convergence of replica exchange simulations using Gibbs sampling and adaptive temperature sets

    CERN Document Server

    Vogel, Thomas

    2015-01-01

    We recently introduced a novel replica-exchange scheme in which an individual replica can sample from states encountered by other replicas at any previous time by way of a global configuration database, enabling the fast propagation of relevant states through the whole ensemble of replicas. This mechanism depends on the knowledge of global thermodynamic functions which are measured during the simulation and not coupled to the heat bath temperatures driving the individual simulations. Therefore, this setup also allows for a continuous adaptation of the temperature set. In this paper, we will review the new scheme and demonstrate its capability. The method is particularly useful for the fast and reliable estimation of the microcanonical temperature T(U) or, equivalently, of the density of states g(U) over a wide range of energies.

  7. Adaptive MANET multipath routing algorithm based on the simulated annealing approach.

    Science.gov (United States)

    Kim, Sungwook

    2014-01-01

    Mobile ad hoc network represents a system of wireless mobile nodes that can freely and dynamically self-organize network topologies without any preexisting communication infrastructure. Due to characteristics like temporary topology and absence of centralized authority, routing is one of the major issues in ad hoc networks. In this paper, a new multipath routing scheme is proposed by employing simulated annealing approach. The proposed metaheuristic approach can achieve greater and reciprocal advantages in a hostile dynamic real world network situation. Therefore, the proposed routing scheme is a powerful method for finding an effective solution into the conflict mobile ad hoc network routing problem. Simulation results indicate that the proposed paradigm adapts best to the variation of dynamic network situations. The average remaining energy, network throughput, packet loss probability, and traffic load distribution are improved by about 10%, 10%, 5%, and 10%, respectively, more than the existing schemes. PMID:25032241

  8. Refined adaptive optics simulation with wide field of view for the E-ELT

    International Nuclear Information System (INIS)

    Refined simulation tools for wide field AO systems (such as MOAO, MCAO or LTAO) on ELTs present new challenges. Increasing the number of degrees of freedom (scales as the square of the telescope diameter) makes the standard simulation's codes useless due to the huge number of operations to be performed at each step of the Adaptive Optics (AO) loop process. This computational burden requires new approaches in the computation of the DM voltages from WFS data. The classical matrix inversion and the matrix vector multiplication have to be replaced by a cleverer iterative resolution of the Least Square or Minimum Mean Square Error criterion (based on sparse matrices approaches). Moreover, for this new generation of AO systems, concepts themselves will become more complex: data fusion coming from multiple Laser and Natural Guide Stars (LGS / NGS) will have to be optimized, mirrors covering all the field of view associated to dedicated mirrors inside the scientific instrument itself will have to be coupled using split or integrated tomography schemes, differential pupil or/and field rotations will have to be considered, etc. All these new entries should be carefully simulated, analysed and quantified in terms of performance before any implementation in AO systems. For those reasons I developed, in collaboration with the ONERA, a full simulation code, based on iterative solution of linear systems with many parameters (use of sparse matrices). On this basis, I introduced new concepts of filtering and data fusion (LGS / NGS) to effectively manage modes such as tip, tilt and defocus in the entire process of tomographic reconstruction. The code will also eventually help to develop and test complex control laws (Multi-DM and multi-field) who have to manage a combination of adaptive telescope and post-focal instrument including dedicated deformable mirrors. The first application of this simulation tool has been studied in the framework of the EAGLE multi-object spectrograph

  9. The evolution of an annual life cycle in killifish: adaptation to ephemeral aquatic environments through embryonic diapause.

    Science.gov (United States)

    Furness, Andrew I

    2016-08-01

    An annual life cycle is characterized by growth, maturity, and reproduction condensed into a single, short season favourable to development, with production of embryos (seeds, cysts, or eggs) capable of surviving harsh conditions which juveniles or adults cannot tolerate. More typically associated with plants in desert environments, or temperate-zone insects exposed to freezing winters, the evolution of an annual life cycle in vertebrates is fairly novel. Killifish, small sexually dimorphic fishes in the Order Cyprinodontiformes, have adapted to seasonally ephemeral water bodies across much of Africa and South America through the independent evolution of an annual life history. These annual killifish produce hardy desiccation-resistant eggs that undergo diapause (developmental arrest) and remain buried in the soil for long periods when fish have perished due to the drying of their habitat. Killifish are found in aquatic habitats that span a continuum from permanent and stable to seasonal and variable, thus providing a useful system in which to piece together the evolutionary history of this life cycle using natural comparative variation. I first review adaptations for life in ephemeral aquatic environments in killifish, with particular emphasis on the evolution of embryonic diapause. I then bring together available evidence from a variety of approaches and provide a scenario for how this annual life cycle evolved. There are a number of features within Aplocheiloidei killifish including their inhabitation of marginal or edge aquatic habitat, their small size and rapid attainment of maturity, and egg properties that make them particularly well suited to the colonization of ephemeral waters. PMID:25969869

  10. Simulating spatial adaption of groundwater pumping on seawater intrusion in coastal regions

    Science.gov (United States)

    Grundmann, Jens; Ladwig, Robert; Schütze, Niels; Walther, Marc

    2016-04-01

    Coastal aquifer systems are used intensively to meet the growing demands for water in those regions. They are especially at risk for the intrusion of seawater due to aquifer overpumping, limited groundwater replenishment and unsustainable groundwater management which in turn also impacts the social and economical development of coastal regions. One example is the Al-Batinah coastal plain in northern Oman where irrigated agriculture is practiced by lots of small scaled farms in different distances from the sea, each of them pumping their water from coastal aquifer. Due to continuous overpumping and progressing saltwater intrusion farms near the coast had to close since water for irrigation got too saline. For investigating appropriate management options numerical density dependent groundwater modelling is required which should also portray the adaption of groundwater abstraction schemes on the water quality. For addressing this challenge a moving inner boundary condition is implemented in the numerical density dependent groundwater model which adjusts the locations for groundwater abstraction according to the position of the seawater intrusion front controlled by thresholds of relative chloride concentration. The adaption process is repeated for each management cycle within transient model simulations and allows for considering feedbacks with the consumers e.g. the agriculture by moving agricultural farms more inland or towards the sea if more fertile soils at the coast could be recovered. For finding optimal water management strategies efficiently, the behaviour of the numerical groundwater model for different extraction and replenishment scenarios is approximated by an artificial neural network using a novel approach for state space surrogate model development. Afterwards the derived surrogate is coupled with an agriculture module within a simulation based water management optimisation framework to achieve optimal cropping pattern and water abstraction schemes

  11. Numerical simulation of strain-adaptive bone remodelling in the ankle joint

    Directory of Open Access Journals (Sweden)

    Stukenborg-Colsman Christina

    2011-07-01

    Full Text Available Abstract Background The use of artificial endoprostheses has become a routine procedure for knee and hip joints while ankle arthritis has traditionally been treated by means of arthrodesis. Due to its advantages, the implantation of endoprostheses is constantly increasing. While finite element analyses (FEA of strain-adaptive bone remodelling have been carried out for the hip joint in previous studies, to our knowledge there are no investigations that have considered remodelling processes of the ankle joint. In order to evaluate and optimise new generation implants of the ankle joint, as well as to gain additional knowledge regarding the biomechanics, strain-adaptive bone remodelling has been calculated separately for the tibia and the talus after providing them with an implant. Methods FE models of the bone-implant assembly for both the tibia and the talus have been developed. Bone characteristics such as the density distribution have been applied corresponding to CT scans. A force of 5,200 N, which corresponds to the compression force during normal walking of a person with a weight of 100 kg according to Stauffer et al., has been used in the simulation. The bone adaptation law, previously developed by our research team, has been used for the calculation of the remodelling processes. Results A total bone mass loss of 2% in the tibia and 13% in the talus was calculated. The greater decline of density in the talus is due to its smaller size compared to the relatively large implant dimensions causing remodelling processes in the whole bone tissue. In the tibia, bone remodelling processes are only calculated in areas adjacent to the implant. Thus, a smaller bone mass loss than in the talus can be expected. There is a high agreement between the simulation results in the distal tibia and the literature regarding. Conclusions In this study, strain-adaptive bone remodelling processes are simulated using the FE method. The results contribute to a better

  12. Water balance in desert arthropods. Despite their small size, arthropods may be highly adapted for life in xeric conditions.

    Science.gov (United States)

    Edney, E B

    1967-05-26

    As judged by the number of species, or of individuals, arthropods are an extremely successful group of desert inhabitants. There is very great structural and physiological diversity within the group, and since adaptations to desert life open to one are not open to all. we should not expect to find the maximum possible development of adaptive features in any arthropod simply because it lives in a desert. Most adult insects fly; their larvae and all other arthropods do not, and their adaptations will differ accordingly. Desert beetles have very impermeable cuticles and tolerate high body temperatures, while desert cockroaches live below the sand. have more permeable cuticles, and absorb water vapor. There is probably no single respect in which all desert arthropods differ from insects of other environments. Perhaps a profitable way of viewing desert animals is to recognize that each is a whole organism with a specific collection of adaptations that must be consistent within themselves and which are associated with a specific mode of life and a specific evolutionary history. The arthropod organization is capable of producing highly efficient desert species. There is, however, a converse way of looking at the situation, Which is often neglected but which may be of general biological interest: does the evolution of adaptations to desert environments necessarily involve loss of viability in more mesic habitats? If so, then what are these disavantages- what, for example, is the disadvantage of a highly impermeable cuticle? In some cases the answer is clear: sandroaches need sand dunes to live in because they are morphologically and behaviorly specialized for this habitat. More often the answer is not obvious. PMID:6024185

  13. Quality assurance for online adapted treatment plans: Benchmarking and delivery monitoring simulation

    Energy Technology Data Exchange (ETDEWEB)

    Li, Taoran, E-mail: taoran.li.duke@gmail.com; Wu, Qiuwen; Yang, Yun; Rodrigues, Anna; Yin, Fang-Fang; Jackie Wu, Q. [Department of Radiation Oncology, Duke University Medical Center Durham, North Carolina 27710 (United States)

    2015-01-15

    Purpose: An important challenge facing online adaptive radiation therapy is the development of feasible and efficient quality assurance (QA). This project aimed to validate the deliverability of online adapted plans and develop a proof-of-concept online delivery monitoring system for online adaptive radiation therapy QA. Methods: The first part of this project benchmarked automatically online adapted prostate treatment plans using traditional portal dosimetry IMRT QA. The portal dosimetry QA results of online adapted plans were compared to original (unadapted) plans as well as randomly selected prostate IMRT plans from our clinic. In the second part, an online delivery monitoring system was designed and validated via a simulated treatment with intentional multileaf collimator (MLC) errors. This system was based on inputs from the dynamic machine information (DMI), which continuously reports actual MLC positions and machine monitor units (MUs) at intervals of 50 ms or less during delivery. Based on the DMI, the system performed two levels of monitoring/verification during the delivery: (1) dynamic monitoring of cumulative fluence errors resulting from leaf position deviations and visualization using fluence error maps (FEMs); and (2) verification of MLC positions against the treatment plan for potential errors in MLC motion and data transfer at each control point. Validation of the online delivery monitoring system was performed by introducing intentional systematic MLC errors (ranging from 0.5 to 2 mm) to the DMI files for both leaf banks. These DMI files were analyzed by the proposed system to evaluate the system’s performance in quantifying errors and revealing the source of errors, as well as to understand patterns in the FEMs. In addition, FEMs from 210 actual prostate IMRT beams were analyzed using the proposed system to further validate its ability to catch and identify errors, as well as establish error magnitude baselines for prostate IMRT delivery

  14. A two-dimensional adaptive spectral element method for the direct simulation of incompressible flow

    Science.gov (United States)

    Hsu, Li-Chieh

    The spectral element method is a high order discretization scheme for the solution of nonlinear partial differential equations. The method draws its strengths from the finite element method for geometrical flexibility and spectral methods for high accuracy. Although the method is, in theory, very powerful for complex phenomena such as transitional flows, its practical implementation is limited by the arbitrary choice of domain discretization. For instance, it is hard to estimate the appropriate number of elements for a specific case. Selection of regions to be refined or coarsened is difficult especially as the flow becomes more complex and memory limits of the computer are stressed. We present an adaptive spectral element method in which the grid is automatically refined or coarsened in order to capture underresolved regions of the domain and to follow regions requiring high resolution as they develop in time. The objective is to provide the best and most efficient solution to a time-dependent nonlinear problem by continually optimizing resource allocation. The adaptivity is based on an error estimator which determines which regions need more resolution. The solution strategy is as follows: compute an initial solution with a suitable initial mesh, estimate errors in the solution locally in each element, modify the mesh according to the error estimators, interpolate old mesh solutions onto the new elements, and resume the numerical solution process. A two-dimensional adaptive spectral element method for the direct simulation of incompressible flows has been developed. The adaptive algorithm effectively diagnoses and refines regions of the flow where complexity of the solution requires increased resolution. The method has been demonstrated on two-dimensional examples in heat conduction, Stokes and Navier-Stokes flows.

  15. The image simulation arithmetic of the degradating process of porous biologic ceramic in life-form

    Institute of Scientific and Technical Information of China (English)

    CHEN Zuo-bing; HUANG Jian-zhong; YAN Yu-hua; LI Shi-pu

    2001-01-01

    @@ It is a complex and difficult task to simulate the degradating process of porous biologic ceramic in life-form by computer. Because the evolvement of crystal' s structure deals with not only the mechanism of many factors, such as crystallography tropism, the reciprocity of wafer, interfacial movement, but also topology geometry mechanism of dimensional padding.

  16. The Game of Social Life: An Assessment of a Multidimensional Poverty Simulation

    Science.gov (United States)

    Bramesfeld, Kosha D.; Good, Arla

    2015-01-01

    This article presents the development of a new simulation activity, the Game of Social Life. The activity introduces students to concepts of social stratification based on multiple dimensions of poverty, including inequalities related to housing, education, occupational status, social power, and health outcomes. The game was administered to…

  17. The fuel cell model of abiogenesis: a new approach to origin-of-life simulations.

    Science.gov (United States)

    Barge, Laura M; Kee, Terence P; Doloboff, Ivria J; Hampton, Joshua M P; Ismail, Mohammed; Pourkashanian, Mohamed; Zeytounian, John; Baum, Marc M; Moss, John A; Lin, Chung-Kuang; Kidd, Richard D; Kanik, Isik

    2014-03-01

    In this paper, we discuss how prebiotic geo-electrochemical systems can be modeled as a fuel cell and how laboratory simulations of the origin of life in general can benefit from this systems-led approach. As a specific example, the components of what we have termed the "prebiotic fuel cell" (PFC) that operates at a putative Hadean hydrothermal vent are detailed, and we used electrochemical analysis techniques and proton exchange membrane (PEM) fuel cell components to test the properties of this PFC and other geo-electrochemical systems, the results of which are reported here. The modular nature of fuel cells makes them ideal for creating geo-electrochemical reactors with which to simulate hydrothermal systems on wet rocky planets and characterize the energetic properties of the seafloor/hydrothermal interface. That electrochemical techniques should be applied to simulating the origin of life follows from the recognition of the fuel cell-like properties of prebiotic chemical systems and the earliest metabolisms. Conducting this type of laboratory simulation of the emergence of bioenergetics will not only be informative in the context of the origin of life on Earth but may help in understanding whether life might emerge in similar environments on other worlds.

  18. "Probing the limits of extremophilic life in extraterrestrial environment-simulated experiments"

    OpenAIRE

    Lage, Claudia; Dalmaso, Gabriel; Teixeira, Lia; Bendia, Amanda; Paulino-Lima, Ivan; Galante, Douglas; Janot-Pacheco, Eduardo; Abrevaya, Ximena; Azúa-Bustos, Armando; Pellizari, Vivian; Rosado, Alexandre

    2012-01-01

    The results obtained in these experiments have revealed a remarkable resistance of extremophilic bacteria and archaea against different radiation sources (VUV, solar wind simulants, X rays) whenever protected by microsized carbonaceus grains. Altogether, the collected data suggest the interesting possibility of the existence of microbial life beyond Earth and its transfer among habitable bodies, which we have called microlithopanspermia.

  19. A Simulation Model for the Real-Life Job-Shop Scheduling Problem

    Directory of Open Access Journals (Sweden)

    Prof. Dr. Gamal M. Nawara

    2013-04-01

    Full Text Available Job-shop scheduling problem (JSSP is very important and has a lot of applications in industrial and service sectors. With good job-shop scheduling, facilities can save time and money. Real-life JSSP is a very big challenge to researchers because of its high complexity. Standard JSSP is a typical NP-hard problem in the strong sense without considering any additional factors. In the real-life JSSP, we need to consider one or more of some factors like transportation times, parallel processing, setup times, and so many factors according to the problem nature. In this paper, we presented a simulation model by Arena simulation software to solve an example from the OR-Library with some modifications considering some factors from the real-life JSSP to show the capability of the proposed approach as shown in section 4. The objective function is to minimize the makespan.

  20. An adaptive actor-critic algorithm with multi-step simulated experiences for controlling nonholonomic mobile robots

    OpenAIRE

    Syam, Rafiuddin

    2007-01-01

    In this paper, we propose a new algorithm of an adaptive actor-critic method with multi-step simulated experiences, as a kind of temporal difference (TD) method. In our approach, the TD-error is composed of two valuefunctions and m utility functions, where m denotes the number ofmulti-steps inwhich the experience should be simulated. The value-function is constructed from the critic formulated by a radial basis function neural network (RBFNN), which has a simulated exp...

  1. Adaptive Challenges Rising from the Life Context of African-American Caregiving Grandmothers with Diabetes: A Pilot Study

    Science.gov (United States)

    Carthron, Dana; Bailey, Donald E.; Anderson, Ruth

    2015-01-01

    To understand the challenges arising from the context within which diabetic African-American caregiving grandmothers self-manage their diabetes we used the Adaptive Leadership Framework. Additionally, challenges to retaining this population in a longitudinal study were examined. In this exploratory, longitudinal, qualitative pilot study, data were collected at five time-points over 18 months. We coded the data using content analysis and conducted the within-case and cross-case analyses using data matrices. Lack of awareness of available resources, represented a technical challenge within the life context of these grandmothers and the remaining three themes: family upheaval; priority setting (with subthemes of difficulty meeting basic needs and competing demands); and self-silencing and self-sacrifice represented adaptive challenges. The context of African-American grandmothers’ lives created primarily adaptive challenges that were complex and without immediate solutions. Research is needed to develop culturally and contextually appropriate interventions to help this vulnerable group develop capacity for adaptive work. PMID:27064619

  2. An adaptive multi-level simulation algorithm for stochastic biological systems

    Science.gov (United States)

    Lester, C.; Yates, C. A.; Giles, M. B.; Baker, R. E.

    2015-01-01

    Discrete-state, continuous-time Markov models are widely used in the modeling of biochemical reaction networks. Their complexity often precludes analytic solution, and we rely on stochastic simulation algorithms (SSA) to estimate system statistics. The Gillespie algorithm is exact, but computationally costly as it simulates every single reaction. As such, approximate stochastic simulation algorithms such as the tau-leap algorithm are often used. Potentially computationally more efficient, the system statistics generated suffer from significant bias unless tau is relatively small, in which case the computational time can be comparable to that of the Gillespie algorithm. The multi-level method [Anderson and Higham, "Multi-level Monte Carlo for continuous time Markov chains, with applications in biochemical kinetics," SIAM Multiscale Model. Simul. 10(1), 146-179 (2012)] tackles this problem. A base estimator is computed using many (cheap) sample paths at low accuracy. The bias inherent in this estimator is then reduced using a number of corrections. Each correction term is estimated using a collection of paired sample paths where one path of each pair is generated at a higher accuracy compared to the other (and so more expensive). By sharing random variables between these paired paths, the variance of each correction estimator can be reduced. This renders the multi-level method very efficient as only a relatively small number of paired paths are required to calculate each correction term. In the original multi-level method, each sample path is simulated using the tau-leap algorithm with a fixed value of τ. This approach can result in poor performance when the reaction activity of a system changes substantially over the timescale of interest. By introducing a novel adaptive time-stepping approach where τ is chosen according to the stochastic behaviour of each sample path, we extend the applicability of the multi-level method to such cases. We demonstrate the

  3. Second Life as a Platform for Physics Simulations and Microworlds: An Evaluation

    CERN Document Server

    Santos, Renato P dos

    2014-01-01

    Often mistakenly seen as a game, the online 3D immersive virtual world Second Life (SL) is itself a huge and sophisticated simulator of an entire Earthlike world. Differently from other metaverses where physical laws are not seriously taken into account, objects created in SL are automatically controlled by a powerful physics engine software. Despite that, it has been used mostly as a mere place for exploration and inquiry, with emphasis on group interaction. This article reports on a study conducted to evaluate the SL environment as a platform for physical simulations and microworlds. It begins by discussing a few relevant features of SL and a few differences found between it and traditional simulators e.g. Modellus. Finally, the SL environment as a platform for physical simulations and microworlds is evaluated. Some concrete examples of simulations in SL, including two of our own authorship, will be presented briefly in order to clarify and enrich both discussion and analysis. However, implementation of sim...

  4. In Patients with Cirrhosis, Driving Simulator Performance is Associated With Real-life Driving

    DEFF Research Database (Denmark)

    Lauridsen, Mette Enok Munk; Thacker, Leroy R; White, Melanie B;

    2016-01-01

    of driving skills improved after each simulation episode. CONCLUSIONS: In a study of 205 patients with cirrhosis, we associated results from driving simulation tests with real-life driving records and MHE. Traffic safety counselling should focus on patients with cirrhosis who recently quit consuming alcohol...... and evaluated changes in simulated driving skills and MHE status after 1 year. METHODS: We performed a study of outpatients with cirrhosis (n=205; median 55 years old; median model for end-stage liver disease score, 9.5; none with overt hepatic encephalopathy or alcohol or illicit drug use within previous 6....... The driving simulator measured crashes, run-time, road center and edge excursions, and illegal turns during navigation; before and after each driving simulation session, patients were asked to rate their overall driving skills. Drivers were classified as safe or unsafe based on crashes and violations reported...

  5. Adaptive resolution simulation of polarizable supramolecular coarse-grained water models

    Energy Technology Data Exchange (ETDEWEB)

    Zavadlav, Julija; Praprotnik, Matej, E-mail: praprot@cmm.ki.si [Laboratory for Molecular Modeling, National Institute of Chemistry, Hajdrihova 19, SI-1001 Ljubljana (Slovenia); Melo, Manuel N.; Marrink, Siewert J., E-mail: s.j.marrink@rug.nl [Groningen Biomolecular Sciences and Biotechnology Institute and Zernike Institute for Advanced Materials, University of Groningen, Nijenborgh 7, 9747 AG Groningen (Netherlands)

    2015-06-28

    Multiscale simulations methods, such as adaptive resolution scheme, are becoming increasingly popular due to their significant computational advantages with respect to conventional atomistic simulations. For these kind of simulations, it is essential to develop accurate multiscale water models that can be used to solvate biophysical systems of interest. Recently, a 4-to-1 mapping was used to couple the bundled-simple point charge water with the MARTINI model. Here, we extend the supramolecular mapping to coarse-grained models with explicit charges. In particular, the two tested models are the polarizable water and big multiple water models associated with the MARTINI force field. As corresponding coarse-grained representations consist of several interaction sites, we couple orientational degrees of freedom of the atomistic and coarse-grained representations via a harmonic energy penalty term. This additional energy term aligns the dipole moments of both representations. We test this coupling by studying the system under applied static external electric field. We show that our approach leads to the correct reproduction of the relevant structural and dynamical properties.

  6. Adaptive multi-stage integrators for optimal energy conservation in molecular simulations

    CERN Document Server

    Fernández-Pendás, Mario; Sanz-Serna, J M

    2015-01-01

    We introduce a new Adaptive Integration Approach (AIA) to be used in a wide range of molecular simulations. Given a simulation problem and a step size, the method automatically chooses the optimal scheme out of an available family of numerical integrators. Although we focus on two-stage splitting integrators, the idea may be used with more general families. In each instance, the system-specific integrating scheme identified by our approach is optimal in the sense that it provides the best conservation of energy for harmonic forces. The AIA method has been implemented in the BCAM-modified GROMACS software package. Numerical tests in molecular dynamics and hybrid Monte Carlo simulations of constrained and unconstrained physical systems show that the method successfully realises the fail-safe strategy. In all experiments, and for each of the criteria employed, the AIA is at least as good as, and often significantly outperforms the standard Verlet scheme, as well as fixed parameter, optimized two-stage integrator...

  7. Adaptive Optics: Arroyo Simulation Tool and Deformable Mirror Actuation Using Golay Cells

    Science.gov (United States)

    Lint, Adam S.

    2005-01-01

    The Arroyo C++ libraries, written by Caltech post-doc student Matthew Britton, have the ability to simulate optical systems and atmospheric signal interference. This program was chosen for use in an end-to-end simulation model of a laser communication system because it is freely distributed and has the ability to be controlled by a remote system or "smart agent." Proposed operation of this program by a smart agent has been demonstrated, and the results show it to be a suitable simulation tool. Deformable mirrors, as a part of modern adaptive optics systems, may contain thousands of tiny, independently controlled actuators used to modify the shape of the mirror. Each actuator is connected to two wires, creating a cumbersome and expensive device. Recently, an alternative actuation method that uses gas-filled tubes known as Golay cells has been explored. Golay cells, operated by infrared lasers instead of electricity, would replace the actuator system thereby creating a more compact deformable mirror. The operation of Golay cells and their ability to move a deformable mirror in excess of the required 20 microns has been demonstrated. Experimentation has shown them to be extremely sensitive to pressure and temperature, making them ideal for use in a controlled environment.

  8. Psychosocial stress based on public speech in humans: is there a real life/laboratory setting cross-adaptation?

    Science.gov (United States)

    Jezova, D; Hlavacova, N; Dicko, I; Solarikova, P; Brezina, I

    2016-07-01

    Repeated or chronic exposure to stressors is associated with changes in neuroendocrine responses depending on the type, intensity, number and frequency of stress exposure as well as previous stress experience. The aim of the study was to test the hypothesis that salivary cortisol and cardiovascular responses to real-life psychosocial stressors related to public performance can cross-adapt with responses to psychosocial stress induced by public speech under laboratory setting. The sample consisted of 22 healthy male volunteers, which were either actors, more precisely students of dramatic arts or non-actors, students of other fields. The stress task consisted of 15 min anticipatory preparation phase and 15 min of public speech on an emotionally charged topic. The actors, who were accustomed to public speaking, responded with a rise in salivary cortisol as well as blood pressure to laboratory public speech. The values of salivary cortisol, systolic blood pressure and state anxiety were lower in actors compared to non-actors. Unlike non-actors, subjects with experience in public speaking did not show stress-induced rise in the heart rate. Evaluation of personality traits revealed that actors scored significantly higher in extraversion than the subjects in the non-actor group. In conclusion, neuroendocrine responses to real-life stressors in actors can partially cross-adapt with responses to psychosocial stress under laboratory setting. The most evident adaptation was at the level of heart rate responses. The public speech tasks may be of help in evaluation of the ability to cope with stress in real life in artists by simple laboratory testing.

  9. Local adaptation at the transcriptome level in brown trout: evidence from early life history temperature genomic reaction norms.

    Directory of Open Access Journals (Sweden)

    Kristian Meier

    Full Text Available Local adaptation and its underlying molecular basis has long been a key focus in evolutionary biology. There has recently been increased interest in the evolutionary role of plasticity and the molecular mechanisms underlying local adaptation. Using transcriptome analysis, we assessed differences in gene expression profiles for three brown trout (Salmo trutta populations, one resident and two anadromous, experiencing different temperature regimes in the wild. The study was based on an F2 generation raised in a common garden setting. A previous study of the F1 generation revealed different reaction norms and significantly higher QST than FST among populations for two early life-history traits. In the present study we investigated if genomic reaction norm patterns were also present at the transcriptome level. Eggs from the three populations were incubated at two temperatures (5 and 8 degrees C representing conditions encountered in the local environments. Global gene expression for fry at the stage of first feeding was analysed using a 32k cDNA microarray. The results revealed differences in gene expression between populations and temperatures and population × temperature interactions, the latter indicating locally adapted reaction norms. Moreover, the reaction norms paralleled those observed previously at early life-history traits. We identified 90 cDNA clones among the genes with an interaction effect that were differently expressed between the ecologically divergent populations. These included genes involved in immune- and stress response. We observed less plasticity in the resident as compared to the anadromous populations, possibly reflecting that the degree of environmental heterogeneity encountered by individuals throughout their life cycle will select for variable level of phenotypic plasticity at the transcriptome level. Our study demonstrates the usefulness of transcriptome approaches to identify genes with different temperature reaction

  10. Translation, cultural adaptation, and validation of the American Skindex-29 quality of life index *

    OpenAIRE

    de Paula, Henrique Ribeiro; Haddad, Alessandra; Weiss, Mariana Alves; Dini, Gal Moreira; Ferreira, Lydia Masako

    2014-01-01

    BACKGROUND Measuring the quality of life measure of patients with dermatologic diseases is an important concern. The instruments to evaluate it are commonly originally written in English and need to be translated and validated to be used in different cultures. OBJECTIVE The purpose of this paper is to translate and validate the Skindex-29 questionnaire to Brazilian Portuguese to be used in our country as a quality of life assessment instrument in dermatologic patients. METHODS The first step ...

  11. The bacterial genus Collimonas mycophagy, weathering, and other adaptive solutions to life in oligotrophic soil environments

    NARCIS (Netherlands)

    Leveau, J.H.J.; Uroz, S.; De Boer, W.

    2010-01-01

    This minireview provides a synopsis of past and present research on the biology and ecology of members of the bacterial genus Collimonas. From the distribution, abundance and functional behaviours of these so-called collimonads emerges a general picture of bacterial adaptation to low-nutrient soil e

  12. Confirmatory Factor Analysis of Persian Adaptation of Multidimensional Students' Life Satisfaction Scale (MSLSS)

    Science.gov (United States)

    Hatami, Gissou; Motamed, Niloofar; Ashrafzadeh, Mahshid

    2010-01-01

    Validity and reliability of Persian adaptation of MSLSS in the 12-18 years, middle and high school students (430 students in grades 6-12 in Bushehr port, Iran) using confirmatory factor analysis by means of LISREL statistical package were checked. Internal consistency reliability estimates (Cronbach's coefficient [alpha]) were all above the…

  13. The life of a dead ant -the expression of an adaptive extended phenotype

    DEFF Research Database (Denmark)

    Andersen, Sandra Breum; Gerritsma, Sylvia; Yusah, Kalsum M.;

    2009-01-01

    to make hosts bite onto vegetation prior to killing them. We show that this represents a fine-tuned fungal adaptation: an extended phenotype. Dead ants were found under leaves, attached by their mandibles, on the northern side of saplings ca. 25 cm above the soil, where temperature and humidity conditions...

  14. Households, Migration and Labor Market Participation: The Adaptation of Mexicans to Life in the United States.

    Science.gov (United States)

    Chavez, Leo R.

    1985-01-01

    The formation of extended family and other non-nuclear family households serves as an important mechanism in the adaptation of Mexican immigrants in San Diego. Different types of households are important at different times in the migration process, and immigration status influences the patterns of household variation. (KH)

  15. The adaptive basis of psychosocial acceleration: Comment on Beyond Mental Health, Life History Strategies Articles [Editorial

    NARCIS (Netherlands)

    Nettle, D.; Frankenhuis, W.E.; Rickard, I.J.

    2012-01-01

    Four of the articles published in this special section of Developmental Psychology build on and refine psychosocial acceleration theory. In this short commentary, we discuss some of the adaptive assumptions of psychosocial acceleration theory that have not received much attention. Psychosocial accel

  16. The Adaptive Basis of Psychosocial Acceleration: Comment on beyond Mental Health, Life History Strategies Articles

    Science.gov (United States)

    Nettle, Daniel; Frankenhuis, Willem E.; Rickard, Ian J.

    2012-01-01

    Four of the articles published in this special section of "Developmental Psychology" build on and refine psychosocial acceleration theory. In this short commentary, we discuss some of the adaptive assumptions of psychosocial acceleration theory that have not received much attention. Psychosocial acceleration theory relies on the behavior of…

  17. Translation to Portuguese and cultural adaptation of Food Allergy Quality of Life Questionnaire - Parent Form (FAQLQ-PF).

    Science.gov (United States)

    Couto, M; Silva, D; Piedade, S; Borrego, Lm; Flokstra-de Blok, B; Dunn Galvin, A; Morais-Almeida, M

    2016-05-01

    Food allergy is a health problem with significant negative impact in Quality of Life (QoL). We aimed to translate into Portuguese and culturally adapt to our population the Food Allergy Quality of Life Questionnaire - Parent Form (FAQLQ-PF). Cross-cultural translation was performed according to guidelines. Linguistic validation consisted in 3 steps: forward translation, backward translation and comprehensibility testing. A consensual version was obtained and tested in parents of food allergic children by cognitive debriefing. Twelve questionnaires were fulfilled, all completed in ≤ 15 min. No comments, doubts or suggestions were posed, except for 2 parents regarding a question about the number of food their children had to avoid. Two gave special positive feedback about the utility of FAQLQ-PF. Changes have been included after this pre-test in accordance to doubts and suggestions of participants, and the Portuguese version is now able to be used in clinics and research.

  18. Local adaptation at the transcriptome level in brown trout: Evidence from early life history temperature genomic reaction norms

    DEFF Research Database (Denmark)

    Meier, Kristian; Hansen, Michael Møller; Normandeau, Eric;

    2014-01-01

    reaction norms and significantly higher QST than FST among populations for two early life-history traits. In the present study we investigated if genomic reaction norm patterns were also present at the transcriptome level. Eggs from the three populations were incubated at two temperatures (5 and 8 degrees......, the latter indicating locally adapted reaction norms. Moreover, the reaction norms paralleled those observed previously at early life-history traits. We identified 90 cDNA clones among the genes with an interaction effect that were differently expressed between the ecologically divergent populations...... phenotypic plasticity at the transcriptome level. Our study demonstrates the usefulness of transcriptome approaches to identify genes with different temperature reaction norms. The responses observed suggest that populations may vary in their susceptibility to climate change....

  19. The rvfit Code: A Detailed Adaptive Simulated Annealing Code for Fitting Binaries and Exoplanets Radial Velocities

    CERN Document Server

    Iglesias-Marzoa, Ramón; Morales, María Jesús Arévalo

    2015-01-01

    The fitting of radial velocity curves is a frequent procedure in binary stars and exoplanet research. In the majority of cases the fitting routines need to be fed with a set of initial parameter values and priors from which to begin the computations and their results can be affected by local minima. We present a new code, the rvfit code, for fitting radial velocities of stellar binaries and exoplanets using an Adaptive Simulated Annealing (ASA) global minimization method, which fastly converges to a global solution minimum without the need to provide preliminary parameter values. We show the performance of the code using both synthetic and real data sets: double-lined binaries, single-lined binaries, and exoplanet systems. In all examples the keplerian orbital parameters fitted by the rvfit code and their computed uncertainties are compared with literature solutions. Finally, we provide the source code with a working example and a detailed description on how to use it.

  20. Adaptive Finite Element Method Assisted by Stochastic Simulation of Chemical Systems

    KAUST Repository

    Cotter, Simon L.

    2013-01-01

    Stochastic models of chemical systems are often analyzed by solving the corresponding Fokker-Planck equation, which is a drift-diffusion partial differential equation for the probability distribution function. Efficient numerical solution of the Fokker-Planck equation requires adaptive mesh refinements. In this paper, we present a mesh refinement approach which makes use of a stochastic simulation of the underlying chemical system. By observing the stochastic trajectory for a relatively short amount of time, the areas of the state space with nonnegligible probability density are identified. By refining the finite element mesh in these areas, and coarsening elsewhere, a suitable mesh is constructed and used for the computation of the stationary probability density. Numerical examples demonstrate that the presented method is competitive with existing a posteriori methods. © 2013 Society for Industrial and Applied Mathematics.

  1. Extreme coronagraphy with an adaptive hologram Simulations of exo-planet imaging

    CERN Document Server

    Ricci, D; Labeyrie, A; 10.1051/0004-6361/200811529

    2009-01-01

    Aims. We present a solution to improve the performance of coronagraphs for the detection of exo-planets. Methods. We simulate numerically several kinds of coronagraphic systems, with the aim of evaluating the gain obtained with an adaptive hologram. Results. The detection limit in flux ratio between a star and a planet (Fs/Fp) observed with an apodized Lyot coronagraph characterized by wavefront bumpiness imperfections of lambda/20 (resp. lambda/100) turns out to be increased by a factor of 10^3.4 (resp. 10^5.1) when equipped with a hologram. Conclusions. This technique could provide direct imaging of an exo-Earth at a distance of 11 parsec with a 6.5m space telescope such as the JWST with the optical quality of the HST.

  2. Optical Cluster-Finding with an Adaptive Matched-Filter Technique: Algorithm and Comparison with Simulations

    Energy Technology Data Exchange (ETDEWEB)

    Dong, Feng; Pierpaoli, Elena; Gunn, James E.; Wechsler, Risa H.

    2007-10-29

    We present a modified adaptive matched filter algorithm designed to identify clusters of galaxies in wide-field imaging surveys such as the Sloan Digital Sky Survey. The cluster-finding technique is fully adaptive to imaging surveys with spectroscopic coverage, multicolor photometric redshifts, no redshift information at all, and any combination of these within one survey. It works with high efficiency in multi-band imaging surveys where photometric redshifts can be estimated with well-understood error distributions. Tests of the algorithm on realistic mock SDSS catalogs suggest that the detected sample is {approx} 85% complete and over 90% pure for clusters with masses above 1.0 x 10{sup 14}h{sup -1} M and redshifts up to z = 0.45. The errors of estimated cluster redshifts from maximum likelihood method are shown to be small (typically less that 0.01) over the whole redshift range with photometric redshift errors typical of those found in the Sloan survey. Inside the spherical radius corresponding to a galaxy overdensity of {Delta} = 200, we find the derived cluster richness {Lambda}{sub 200} a roughly linear indicator of its virial mass M{sub 200}, which well recovers the relation between total luminosity and cluster mass of the input simulation.

  3. Clustering of tethered satellite system simulation data by an adaptive neuro-fuzzy algorithm

    Science.gov (United States)

    Mitra, Sunanda; Pemmaraju, Surya

    1992-01-01

    Recent developments in neuro-fuzzy systems indicate that the concepts of adaptive pattern recognition, when used to identify appropriate control actions corresponding to clusters of patterns representing system states in dynamic nonlinear control systems, may result in innovative designs. A modular, unsupervised neural network architecture, in which fuzzy learning rules have been embedded is used for on-line identification of similar states. The architecture and control rules involved in Adaptive Fuzzy Leader Clustering (AFLC) allow this system to be incorporated in control systems for identification of system states corresponding to specific control actions. We have used this algorithm to cluster the simulation data of Tethered Satellite System (TSS) to estimate the range of delta voltages necessary to maintain the desired length rate of the tether. The AFLC algorithm is capable of on-line estimation of the appropriate control voltages from the corresponding length error and length rate error without a priori knowledge of their membership functions and familarity with the behavior of the Tethered Satellite System.

  4. An adaptive evolutionary multi-objective approach based on simulated annealing.

    Science.gov (United States)

    Li, H; Landa-Silva, D

    2011-01-01

    A multi-objective optimization problem can be solved by decomposing it into one or more single objective subproblems in some multi-objective metaheuristic algorithms. Each subproblem corresponds to one weighted aggregation function. For example, MOEA/D is an evolutionary multi-objective optimization (EMO) algorithm that attempts to optimize multiple subproblems simultaneously by evolving a population of solutions. However, the performance of MOEA/D highly depends on the initial setting and diversity of the weight vectors. In this paper, we present an improved version of MOEA/D, called EMOSA, which incorporates an advanced local search technique (simulated annealing) and adapts the search directions (weight vectors) corresponding to various subproblems. In EMOSA, the weight vector of each subproblem is adaptively modified at the lowest temperature in order to diversify the search toward the unexplored parts of the Pareto-optimal front. Our computational results show that EMOSA outperforms six other well established multi-objective metaheuristic algorithms on both the (constrained) multi-objective knapsack problem and the (unconstrained) multi-objective traveling salesman problem. Moreover, the effects of the main algorithmic components and parameter sensitivities on the search performance of EMOSA are experimentally investigated.

  5. Adaptive Wavelet-Based Direct Numerical Simulations of Rayleigh-Taylor Instability

    Science.gov (United States)

    Reckinger, Scott J.

    The compressible Rayleigh-Taylor instability (RTI) occurs when a fluid of low molar mass supports a fluid of higher molar mass against a gravity-like body force or in the presence of an accelerating front. Intrinsic to the problem are highly stratified background states, acoustic waves, and a wide range of physical scales. The objective of this thesis is to develop a specialized computational framework that addresses these challenges and to apply the advanced methodologies for direct numerical simulations of compressible RTI. Simulations are performed using the Parallel Adaptive Wavelet Collocation Method (PAWCM). Due to the physics-based adaptivity and direct error control of the method, PAWCM is ideal for resolving the wide range of scales present in RTI growth. Characteristics-based non-reflecting boundary conditions are developed for highly stratified systems to be used in conjunction with PAWCM. This combination allows for extremely long domains, which is necessary for observing the late time growth of compressible RTI. Initial conditions that minimize acoustic disturbances are also developed. The initialization is consistent with linear stability theory, where the background state consists of two diffusively mixed stratified fluids of differing molar masses. The compressibility effects on the departure from the linear growth, the onset of strong non-linear interactions, and the late-time behavior of the fluid structures are investigated. It is discovered that, for the thermal equilibrium case, the background stratification acts to suppress the instability growth when the molar mass difference is small. A reversal in this monotonic behavior is observed for large molar mass differences, where stratification enhances the bubble growth. Stratification also affects the vortex creation and the associated induced velocities. The enhancement and suppression of the RTI growth has important consequences for a detailed understanding of supernovae flame front

  6. Development of Efficient Finite Element Software of Crack Propagation Simulation using Adaptive Mesh Strategy

    Directory of Open Access Journals (Sweden)

    Abdulnaser M. Alshoaibi

    2009-01-01

    Full Text Available The purpose of this study is on the determination of 2D crack paths and surfaces as well as on the evaluation of the stress intensity factors as a part of the damage tolerant assessment. Problem statement: The evaluation of SIFs and crack tip singular stresses for arbitrary fracture structure are a challenging problem, involving the calculation of the crack path and the crack propagation rates at each step especially under mixed mode loading. Approach: This study was provided a finite element code which produces results comparable to the current available commercial software. Throughout the simulation of crack propagation an automatic adaptive mesh was carried out in the vicinity of the crack front nodes and in the elements which represent the higher stresses distribution. The finite element mesh was generated using the advancing front method. The adaptive remising process carried out based on the posteriori stress error norm scheme to obtain an optimal mesh. The onset criterion of crack propagation was based on the stress intensity factors which provide as the most important parameter that must be accurately estimated. Facilitated by the singular elements, the displacement extrapolation technique is employed to calculate the stress intensity factor. Crack direction is predicted using the maximum circumferential stress theory. The fracture was modeled by the splitting node approach and the trajectory follows the successive linear extensions of each crack increment. The propagation process is driven by Linear Elastic Fracture Mechanics (LEFM approach with minimum user interaction. Results: In evaluating the accuracy of the estimated stress intensity factors and the crack path predictions, the results were compared with sets of experimental data, benchmark analytical solutions as well as numerical results of other researchers. Conclusion/Recommendations: The assessment indicated that the program was highly reliable to evaluate the stress intensity

  7. Simulation of Runoff Concentration on Arable Fields and the Impact of Adapted Tillage Practises

    Science.gov (United States)

    Winter, F.; Disse, M.

    2012-04-01

    Conservational tillage can reduce runoff on arable fields. Due to crop residues remaining on the fields a seasonal constant ground cover is achieved. This additional soil cover not only decreases the drying of the topsoil but also reduces the mechanical impact of raindrops and the possibly resulting soil crust. Further implications of the mulch layer can be observed during heavy precipitation events and occurring surface runoff. The natural roughness of the ground surface is further increased and thus the flow velocity is decreased, resulting in an enhanced ability of runoff to infiltrate into the soil (so called Runon-Infiltration). The hydrological model system WaSiM-ETH hitherto simulates runoff concentration by a flow time grid in the catchment, which is derived from topographical features of the catchment during the preprocessing analysis. The retention of both surface runoff and interflow is modelled by a single reservoir in every discrete flow time zone until the outlet of a subcatchment is reached. For a more detailed analysis of the flow paths in catchments of the lower mesoscale (small-scale variation in runoff generation and its temporal distribution in detail. Therefore the assessment of adapted tillage systems can be derived. On singular fields of the Scheyern research farm north-west of Munich it can be shown how different crops and tillage practises can influence runoff generation and concentration during single heavy precipitation events. From the simulation of individual events in agricultural areas of the lower mesoscale hydrologically susceptible areas can be identified and the positive impact of an adapted agricultural management on runoff generation and concentration can be quantifed.

  8. Direct numerical simulations of particle-laden density currents with adaptive, discontinuous finite elements

    Directory of Open Access Journals (Sweden)

    S. D. Parkinson

    2014-05-01

    Full Text Available High resolution direct numerical simulations (DNS are an important tool for the detailed analysis of turbidity current dynamics. Models that resolve the vertical structure and turbulence of the flow are typically based upon the Navier–Stokes equations. Two-dimensional simulations are known to produce unrealistic cohesive vortices that are not representative of the real three-dimensional physics. The effect of this phenomena is particularly apparent in the later stages of flow propagation. The ideal solution to this problem is to run the simulation in three dimensions but this is computationally expensive. This paper presents a novel finite-element (FE DNS turbidity current model that has been built within Fluidity, an open source, general purpose, computational fluid dynamics code. The model is validated through re-creation of a lock release density current at a Grashof number of 5 × 106 in two, and three-dimensions. Validation of the model considers the flow energy budget, sedimentation rate, head speed, wall normal velocity profiles and the final deposit. Conservation of energy in particular is found to be a good metric for measuring mesh performance in capturing the range of dynamics. FE models scale well over many thousands of processors and do not impose restrictions on domain shape, but they are computationally expensive. Use of discontinuous discretisations and adaptive unstructured meshing technologies, which reduce the required element count by approximately two orders of magnitude, results in high resolution DNS models of turbidity currents at a fraction of the cost of traditional FE models. The benefits of this technique will enable simulation of turbidity currents in complex and large domains where DNS modelling was previously unachievable.

  9. Adaptive Planning: Understanding Organizational Workload to Capability/ Capacity through Modeling and Simulation

    Science.gov (United States)

    Hase, Chris

    2010-01-01

    In August 2003, the Secretary of Defense (SECDEF) established the Adaptive Planning (AP) initiative [1] with an objective of reducing the time necessary to develop and revise Combatant Commander (COCOM) contingency plans and increase SECDEF plan visibility. In addition to reducing the traditional plan development timeline from twenty-four months to less than twelve months (with a goal of six months)[2], AP increased plan visibility to Department of Defense (DoD) leadership through In-Progress Reviews (IPRs). The IPR process, as well as the increased number of campaign and contingency plans COCOMs had to develop, increased the workload while the number of planners remained fixed. Several efforts from collaborative planning tools to streamlined processes were initiated to compensate for the increased workload enabling COCOMS to better meet shorter planning timelines. This paper examines the Joint Strategic Capabilities Plan (JSCP) directed contingency planning and staffing requirements assigned to a combatant commander staff through the lens of modeling and simulation. The dynamics of developing a COCOM plan are captured with an ExtendSim [3] simulation. The resulting analysis provides a quantifiable means by which to measure a combatant commander staffs workload associated with development and staffing JSCP [4] directed contingency plans with COCOM capability/capacity. Modeling and simulation bring significant opportunities in measuring the sensitivity of key variables in the assessment of workload to capability/capacity analysis. Gaining an understanding of the relationship between plan complexity, number of plans, planning processes, and number of planners with time required for plan development provides valuable information to DoD leadership. Through modeling and simulation AP leadership can gain greater insight in making key decisions on knowing where to best allocate scarce resources in an effort to meet DoD planning objectives.

  10. The morphing method as a flexible tool for adaptive local/non-local simulation of static fracture

    KAUST Repository

    Azdoud, Yan

    2014-04-19

    We introduce a framework that adapts local and non-local continuum models to simulate static fracture problems. Non-local models based on the peridynamic theory are promising for the simulation of fracture, as they allow discontinuities in the displacement field. However, they remain computationally expensive. As an alternative, we develop an adaptive coupling technique based on the morphing method to restrict the non-local model adaptively during the evolution of the fracture. The rest of the structure is described by local continuum mechanics. We conduct all simulations in three dimensions, using the relevant discretization scheme in each domain, i.e., the discontinuous Galerkin finite element method in the peridynamic domain and the continuous finite element method in the local continuum mechanics domain. © 2014 Springer-Verlag Berlin Heidelberg.

  11. A Case-Study for Life-Long Learning and Adaptation in Cooperative Robot Teams

    Energy Technology Data Exchange (ETDEWEB)

    Parker, L.E.

    1999-09-19

    While considerable progress has been made in recent years toward the development of multi-robot teams, much work remains to be done before these teams are used widely in real-world applications. Two particular needs toward this end are the development of mechanisms that enable robot teams to generate cooperative behaviors on their own, and the development of techniques that allow these teams to autonomously adapt their behavior over time as the environment or the robot team changes. This paper proposes the use of the Cooperative Multi-Robot Observation of Multiple Moving Targets (CMOMMT) application as a rich domain for studying the issues of multi-robot learning and adaptation. After discussing the need for learning and adaptation in multi-robot teams, this paper describes the CMOMMT application and its relevance to multi-robot learning. We discuss the results of the previously- developed, hand-generated algorithm for CMOMMT and the potential for learning that was discovered from the hand-generated approach. We then describe the early work that has been done (by us and others) to generate multi- robot learning techniques for the CMOMMT application, as well as our ongoing research to develop approaches that give performance as good, or better, than the hand-generated approach. The ultimate goal of this research is to develop techniques for multi-robot learning and adaptation in the CMOMMT application domain that will generalize to cooperative robot applications in other domains, thus making the practical use of multi-robot teams in a wide variety of real-world applications much closer to reality.

  12. A Case-Study for Life-Long Learning and Adaptation in Cooperative Robot Teams

    International Nuclear Information System (INIS)

    While considerable progress has been made in recent years toward the development of multi-robot teams, much work remains to be done before these teams are used widely in real-world applications. Two particular needs toward this end are the development of mechanisms that enable robot teams to generate cooperative behaviors on their own, and the development of techniques that allow these teams to autonomously adapt their behavior over time as the environment or the robot team changes. This paper proposes the use of the Cooperative Multi-Robot Observation of Multiple Moving Targets (CMOMMT) application as a rich domain for studying the issues of multi-robot learning and adaptation. After discussing the need for learning and adaptation in multi-robot teams, this paper describes the CMOMMT application and its relevance to multi-robot learning. We discuss the results of the previously- developed, hand-generated algorithm for CMOMMT and the potential for learning that was discovered from the hand-generated approach. We then describe the early work that has been done (by us and others) to generate multi- robot learning techniques for the CMOMMT application, as well as our ongoing research to develop approaches that give performance as good, or better, than the hand-generated approach. The ultimate goal of this research is to develop techniques for multi-robot learning and adaptation in the CMOMMT application domain that will generalize to cooperative robot applications in other domains, thus making the practical use of multi-robot teams in a wide variety of real-world applications much closer to reality

  13. Acetic acid bacteria genomes reveal functional traits for adaptation to life in insect guts

    OpenAIRE

    B. Chouaia; Gaiarsa, S.; Crotti, E.; Comandatore, F.; Degli Esposti, M.; I. RICCI; Alma, A.; Favia, G.; Bandi, C.; D. Daffonchio

    2014-01-01

    Acetic acid bacteria (AAB) live in sugar rich environments, including food matrices, plant tissues, and the gut of sugar-feeding insects. By comparing the newly sequenced genomes of Asaia platycodi and Saccharibacter sp., symbionts of Anopheles stephensi and Apis mellifera, respectively, with those of 14 other AAB, we provide a genomic view of the evolutionary pattern of this bacterial group and clues on traits that explain the success of AAB as insect symbionts. A specific pre-adaptive trait...

  14. The adaptive potential of early life-stage Fucus vesiculosus under multifactorial environmental change

    OpenAIRE

    Al-Janabi, Balsam

    2016-01-01

    Multiple global and local stressors threaten populations of the bladderwrack Fucus vesiculosus (Phaeophyceae). Baltic F. vesiculosus populations presumably have a lower genetic diversity compared to other populations. I investigated the adaptive potential under multifactorial environmental change in F. vesiculosus germlings. Effects of warming and acidification were crossed during one year at the two levels “present” and “future” (according to the year 2110) at the “Kiel Outdoor Benthocosm...

  15. Polar bears exhibit genome-wide signatures of bioenergetic adaptation to life in the Arctic environment

    Science.gov (United States)

    Welch, Andreanna J.; Bedoya-Reina, Oscar C.; Carretero-Paulet, Lorenzo; Miller, Webb; Rode, Karyn D.; Lindqvist, Charlotte

    2014-01-01

    Polar bears (Ursus maritimus) face extremely cold temperatures and periods of fasting, which might result in more severe energetic challenges than those experienced by their sister species, the brown bear (U. arctos). We have examined the mitochondrial and nuclear genomes of polar and brown bears to investigate if polar bears demonstrate lineage-specific signals of molecular adaptation in genes associated with cellular respiration/energy production. We observed increased evolutionary rates in the mitochondrial cytochrome c oxidase I gene in polar but not brown bears. An amino acid substitution occurred near the interaction site with a nuclear-encoded subunit of the cytochrome c oxidase complex, and was predicted to lead to a functional change, although the significance of this remains unclear. The nuclear genomes of brown and polar bears demonstrate different adaptations related to cellular respiration. Analyses of the genomes of brown bears exhibited substitutions that may alter the function of proteins that regulate glucose uptake, which could be beneficial when feeding on carbohydrate-dominated diets during hyperphagia, followed by fasting during hibernation. In polar bears, genes demonstrating signatures of functional divergence and those potentially under positive selection were enriched in functions related to production of nitric oxide, which can regulate energy production in several different ways. This suggests that polar bears may be able to fine-tune intracellular levels of nitric oxide as an adaptive response to control trade-offs between energy production in the form of ATP versus generation of heat (thermogenesis).

  16. Polar Bears Exhibit Genome-Wide Signatures of Bioenergetic Adaptation to Life in the Arctic Environment

    Science.gov (United States)

    Welch, Andreanna J.; Carretero-Paulet, Lorenzo; Miller, Webb; Rode, Karyn D.; Lindqvist, Charlotte

    2014-01-01

    Polar bears (Ursus maritimus) face extremely cold temperatures and periods of fasting, which might result in more severe energetic challenges than those experienced by their sister species, the brown bear (U. arctos). We have examined the mitochondrial and nuclear genomes of polar and brown bears to investigate whether polar bears demonstrate lineage-specific signals of molecular adaptation in genes associated with cellular respiration/energy production. We observed increased evolutionary rates in the mitochondrial cytochrome c oxidase I gene in polar but not brown bears. An amino acid substitution occurred near the interaction site with a nuclear-encoded subunit of the cytochrome c oxidase complex and was predicted to lead to a functional change, although the significance of this remains unclear. The nuclear genomes of brown and polar bears demonstrate different adaptations related to cellular respiration. Analyses of the genomes of brown bears exhibited substitutions that may alter the function of proteins that regulate glucose uptake, which could be beneficial when feeding on carbohydrate-dominated diets during hyperphagia, followed by fasting during hibernation. In polar bears, genes demonstrating signatures of functional divergence and those potentially under positive selection were enriched in functions related to production of nitric oxide (NO), which can regulate energy production in several different ways. This suggests that polar bears may be able to fine-tune intracellular levels of NO as an adaptive response to control trade-offs between energy production in the form of adenosine triphosphate versus generation of heat (thermogenesis). PMID:24504087

  17. Fast simulation of transport and adaptive permeability estimation in porous media

    Energy Technology Data Exchange (ETDEWEB)

    Berre, Inga

    2005-07-01

    The focus of the thesis is twofold: Both fast simulation of transport in porous media and adaptive estimation of permeability are considered. A short introduction that motivates the work on these topics is given in Chapter 1. In Chapter 2, the governing equations for one- and two-phase flow in porous media are presented. Overall numerical solution strategies for the two-phase flow model are also discussed briefly. The concepts of streamlines and time-of-flight are introduced in Chapter 3. Methods for computing streamlines and time-of-flight are also presented in this chapter. Subsequently, in Chapters 4 and 5, the focus is on simulation of transport in a time-of-flight perspective. In Chapter 4, transport of fluids along streamlines is considered. Chapter 5 introduces a different viewpoint based on the evolution of isocontours of the fluid saturation. While the first chapters focus on the forward problem, which consists in solving a mathematical model given the reservoir parameters, Chapters 6, 7 and 8 are devoted to the inverse problem of permeability estimation. An introduction to the problem of identifying spatial variability in reservoir permeability by inversion of dynamic production data is given in Chapter 6. In Chapter 7, adaptive multiscale strategies for permeability estimation are discussed. Subsequently, Chapter 8 presents a level-set approach for improving piecewise constant permeability representations. Finally, Chapter 9 summarizes the results obtained in the thesis; in addition, the chapter gives some recommendations and suggests directions for future work. Part II In Part II, the following papers are included in the order they were completed: Paper A: A Streamline Front Tracking Method for Two- and Three-Phase Flow Including Capillary Forces. I. Berre, H. K. Dahle, K. H. Karlsen, and H. F. Nordhaug. In Fluid flow and transport in porous media: mathematical and numerical treatment (South Hadley, MA, 2001), volume 295 of Contemp. Math., pages 49

  18. Scale-adaptive simulation of flow past wavy cylinders at a subcritical Reynolds number

    Institute of Scientific and Technical Information of China (English)

    Rui Zhao; Jing-Lei Xu; Chao Yan; Jian Yu

    2011-01-01

    The Xu &Yan scale-adaptive simulation (XYSAS) model is employed to simulate the flows past wavy cylinders at Reynolds number 8 × 103.This approach yields results in good agreement with experimental measurements.The mean flow field and near wake vortex structure are replicated and compared with that of a corresponding circular cylinder.The effects of wavelength ratios λ/Dm from 3 to 7,together with the amplitude ratios α/Dm of 0.091 and 0.25,are fully investigated.Owing to the wavy configuration,a maximum reduction of Strouhal number and root-meansquare (r.m.s) fluctuating lift coefficients are up to 50% and 92%,respectively,which means the vortex induced vibration (VIV) could be effectively alleviated at certain larger values ofλ/Dm and a/Dm.Also,the drag coefficients can be reduced by 30%.It is found that the flow field presents contrary patterns with the increase ofλ/Dm.The free shear layer becomes much more stable and rolls up into mature vortex only further downstream whenλ/Dm falls in the range of 5-7.The amplitude ratio α/Dm greatly changes the separation line,and subsequently influences the wake structures.

  19. Stochastic Global Optimization and Its Applications with Fuzzy Adaptive Simulated Annealing

    CERN Document Server

    Aguiar e Oliveira Junior, Hime; Petraglia, Antonio; Rembold Petraglia, Mariane; Augusta Soares Machado, Maria

    2012-01-01

    Stochastic global optimization is a very important subject, that has applications in virtually all areas of science and technology. Therefore there is nothing more opportune than writing a book about a successful and mature algorithm that turned out to be a good tool in solving difficult problems. Here we present some techniques for solving  several problems by means of Fuzzy Adaptive Simulated Annealing (Fuzzy ASA), a fuzzy-controlled version of ASA, and by ASA itself. ASA is a sophisticated global optimization algorithm that is based upon ideas of the simulated annealing paradigm, coded in the C programming language and developed to statistically find the best global fit of a nonlinear constrained, non-convex cost function over a multi-dimensional space. By presenting detailed examples of its application we want to stimulate the reader’s intuition and make the use of Fuzzy ASA (or regular ASA) easier for everyone wishing to use these tools to solve problems. We kept formal mathematical requirements to a...

  20. Lyα RADIATIVE TRANSFER IN COSMOLOGICAL SIMULATIONS USING ADAPTIVE MESH REFINEMENT

    International Nuclear Information System (INIS)

    A numerical code for solving various Lyα radiative transfer (RT) problems is presented. The code is suitable for an arbitrary, three-dimensional distribution of Lyα emissivity, gas temperature, density, and velocity field. Capable of handling Lyα RT in an adaptively refined grid-based structure, it enables detailed investigation of the effects of clumpiness of the interstellar (or intergalactic) medium. The code is tested against various geometrically and physically idealized configurations for which analytical solutions exist, and subsequently applied to three different simulated high-resolution 'Lyman-break galaxies', extracted from high-resolution cosmological simulations at redshift z = 3.6. Proper treatment of the Lyα scattering reveals a diversity of surface brightness (SB) and line profiles. Specifically, for a given galaxy the maximum observed SB can vary by an order of magnitude, and the total flux by a factor of 3-6, depending on the viewing angle. This may provide an explanation for differences in observed properties of high-redshift galaxies, and in particular a possible physical link between Lyman-break galaxies and regular Lyα emitters.

  1. The Numerical Simulation of Ship Waves Using Cartesian Grid Methods with Adaptive Mesh Refinement

    CERN Document Server

    Dommermuth, Douglas G; Beck, Robert F; O'Shea, Thomas T; Wyatt, Donald C; Olson, Kevin; MacNeice, Peter

    2014-01-01

    Cartesian-grid methods with Adaptive Mesh Refinement (AMR) are ideally suited for simulating the breaking of waves, the formation of spray, and the entrainment of air around ships. As a result of the cartesian-grid formulation, minimal input is required to describe the ships geometry. A surface panelization of the ship hull is used as input to automatically generate a three-dimensional model. No three-dimensional gridding is required. The AMR portion of the numerical algorithm automatically clusters grid points near the ship in regions where wave breaking, spray formation, and air entrainment occur. Away from the ship, where the flow is less turbulent, the mesh is coarser. The numerical computations are implemented using parallel algorithms. Together, the ease of input and usage, the ability to resolve complex free-surface phenomena, and the speed of the numerical algorithms provide a robust capability for simulating the free-surface disturbances near a ship. Here, numerical predictions, with and without AMR,...

  2. Adaptations to isolated shoulder fatigue during simulated repetitive work. Part II: Recovery.

    Science.gov (United States)

    McDonald, Alison C; Tse, Calvin T F; Keir, Peter J

    2016-08-01

    The shoulder allows kinematic and muscular changes to facilitate continued task performance during prolonged repetitive work. The purpose of this work was to examine changes during simulated repetitive work in response to a fatigue protocol. Participants performed 20 one-minute work cycles comprised of 4 shoulder centric tasks, a fatigue protocol, followed by 60 additional cycles. The fatigue protocol targeted the anterior deltoid and cycled between static and dynamic actions. EMG was collected from 14 upper extremity and back muscles and three-dimensional motion was captured during each work cycle. Participants completed post-fatigue work despite EMG manifestations of muscle fatigue, reduced flexion strength (by 28%), and increased perceived exertion (∼3 times). Throughout the post-fatigue work cycles, participants maintained performance via kinematic and muscular adaptations, such as reduced glenohumeral flexion and scapular rotation which were task specific and varied throughout the hour of simulated work. By the end of 60 post-fatigue work cycles, signs of fatigue persisted in the anterior deltoid and developed in the middle deltoid, yet perceived exertion and strength returned to pre-fatigue levels. Recovery from fatigue elicits changes in muscle activity and movement patterns that may not be perceived by the worker which has important implications for injury risk. PMID:26076931

  3. Translation, Adaptation and Initial Validation of Food Allergy Quality of Life Questionnaire: Child form in Greek

    Science.gov (United States)

    Morou, Zoe; Lyrakos, Georgios N.; Papadopoulos, Nikolaos G.; Douladiris, Nikolaos; Tatsioni, Athina; Dimoliatis, Ioannis D.K.

    2016-01-01

    The aim of the study is to determine the reliability and validity of the Greek version of the Food Allergy Quality of life Questionnaire-Child Form (FAQLQ-CF). After linguistic validation, the Greek FAQLQ-CF, Food Allergy Independent Measure (FAIM) and Pediatric Quality of Life Inventory (PedsQL™) were used by a physician to interview children diagnosed with food allergy and aged 8-12 via telephone. Cronbach’s alpha was used to evaluate reliability, and factor analysis to assess construct validity. The correlation between FAQLQ-CF and FAIM was moderate (rho=0.509, PCronbach’s alpha 0.905). FAQLQ-CF discriminated well each question’s contribution to children’s quality of life deterioration (32-80%), each child’s quality of life (17-89%), children differing in doing things with others (total score 3.55 vs 2.57, difference =0.98 > minimal clinical importance difference = 0.5; P<0.001), but not children differing in reporting anaphylaxis. The total FAQLQ-CF score correlated with the total PedsQL™ score and with the score of one of PedsQL™ subscales, demonstrating convergent validity. Factor analysis uncovered an underlying structure of four factors, explaining 50% of the variance. We can conclude that Greek FAQLQ-CF is a reliable, valid, discriminant tool for interviewing food allergic children aged 8-12, detecting those in need for immediate care. PMID:27403459

  4. Translation, cultural adaptation, and validation of the American Skindex-29 quality of life index*

    Science.gov (United States)

    de Paula, Henrique Ribeiro; Haddad, Alessandra; Weiss, Mariana Alves; Dini, Gal Moreira; Ferreira, Lydia Masako

    2014-01-01

    BACKGROUND Measuring the quality of life measure of patients with dermatologic diseases is an important concern. The instruments to evaluate it are commonly originally written in English and need to be translated and validated to be used in different cultures. OBJECTIVE The purpose of this paper is to translate and validate the Skindex-29 questionnaire to Brazilian Portuguese to be used in our country as a quality of life assessment instrument in dermatologic patients. METHODS The first step was the translation from English to Brazilian Portuguese and the back-translation by two native speakers. The translated version was then used for the second step, when three questionnaires were applied to 75 patients (43 of whom were classified as lightly affected and 32 as heavily affected by their dermatologic conditions): an identification questionnaire, the translated version of Skindex-29, and the Brazilian Portuguese version of Dermatologic Life Quality Index (DLQI). Additionally, the generic questionnaire Short Form 36 (SF-36) was applied to 41 of these patients. The last step to evaluate reproducibility was repeating the Skindex-29 questionnaire by the same researcher one week later in 44 patients. RESULTS Reliability was observed in global Skindex-29 scale (α=0.934), and its domains emotions (α=0.926), symptoms (α=0,702), and psycosocial functioning (α=0.860). The reproducibility showed high intraclass correlations. High intra class correlations was observed, thus validating reliability. CONCLUSIONS The Skindex-29 quality of life questionnaire was properly translated and validated to Brazilian Portuguese. PMID:25054747

  5. Design, development, and performance of an adapter for simulation of ocular melanoma patients in supine position for proton beam therapy

    Science.gov (United States)

    Daftari, I.; Phillips, T. L.

    2003-06-01

    A patient assembly adapter system for ocular melanoma patient simulation was developed and its performance evaluated. The aim for the construction of the apparatus was to simulate the patients in supine position using a commercial x-ray simulator. The apparatus consists of a base plate, head immobilization holder, patient assembly system that includes fixation light and collimator system. The reproducibility of the repeated fixation was initially tested with a head phantom. Simulation and verification films were studied for seven consecutive patients treated with proton beam therapy. Patient's simulation was performed in a supine position using a dental fixation bite block and a thermoplastic head mask immobilization device with a patient adapter system. Two orthogonal x rays were used to obtain the x, y, and z coordinates of sutured tantalum rings for treatment planning with the EYEPLAN software. The verification films were obtained in treatment position with the fixation light along the central axis of the eye. The results indicate good agreement within 0.5 mm deviations. The results of this investigation showed that the same planning accuracy could be achieved by performing simulation using the adapter described above with a patient in the supine position as that obtained by performing simulation with the patient in the seated, treatment position. The adapter can also be attached to the head of the chair for simulating in the seated position using a fixed x-ray unit. This has three advantages: (1) this will save radiation therapists time; (2) it eliminates the need for arranging access to the treatment room, thus avoiding potential conflicts in treatment room usage; and (3) it allows the use of a commercial simulator.

  6. THREE-DIMENSIONAL ADAPTIVE MESH REFINEMENT SIMULATIONS OF LONG-DURATION GAMMA-RAY BURST JETS INSIDE MASSIVE PROGENITOR STARS

    Energy Technology Data Exchange (ETDEWEB)

    Lopez-Camara, D.; Lazzati, Davide [Department of Physics, NC State University, 2401 Stinson Drive, Raleigh, NC 27695-8202 (United States); Morsony, Brian J. [Department of Astronomy, University of Wisconsin-Madison, 2535 Sterling Hall, 475 N. Charter Street, Madison, WI 53706-1582 (United States); Begelman, Mitchell C., E-mail: dlopezc@ncsu.edu [JILA, University of Colorado, 440 UCB, Boulder, CO 80309-0440 (United States)

    2013-04-10

    We present the results of special relativistic, adaptive mesh refinement, 3D simulations of gamma-ray burst jets expanding inside a realistic stellar progenitor. Our simulations confirm that relativistic jets can propagate and break out of the progenitor star while remaining relativistic. This result is independent of the resolution, even though the amount of turbulence and variability observed in the simulations is greater at higher resolutions. We find that the propagation of the jet head inside the progenitor star is slightly faster in 3D simulations compared to 2D ones at the same resolution. This behavior seems to be due to the fact that the jet head in 3D simulations can wobble around the jet axis, finding the spot of least resistance to proceed. Most of the average jet properties, such as density, pressure, and Lorentz factor, are only marginally affected by the dimensionality of the simulations and therefore results from 2D simulations can be considered reliable.

  7. Using Multivariate Adaptive Regression Spline and Artificial Neural Network to Simulate Urbanization in Mumbai, India

    Science.gov (United States)

    Ahmadlou, M.; Delavar, M. R.; Tayyebi, A.; Shafizadeh-Moghadam, H.

    2015-12-01

    Land use change (LUC) models used for modelling urban growth are different in structure and performance. Local models divide the data into separate subsets and fit distinct models on each of the subsets. Non-parametric models are data driven and usually do not have a fixed model structure or model structure is unknown before the modelling process. On the other hand, global models perform modelling using all the available data. In addition, parametric models have a fixed structure before the modelling process and they are model driven. Since few studies have compared local non-parametric models with global parametric models, this study compares a local non-parametric model called multivariate adaptive regression spline (MARS), and a global parametric model called artificial neural network (ANN) to simulate urbanization in Mumbai, India. Both models determine the relationship between a dependent variable and multiple independent variables. We used receiver operating characteristic (ROC) to compare the power of the both models for simulating urbanization. Landsat images of 1991 (TM) and 2010 (ETM+) were used for modelling the urbanization process. The drivers considered for urbanization in this area were distance to urban areas, urban density, distance to roads, distance to water, distance to forest, distance to railway, distance to central business district, number of agricultural cells in a 7 by 7 neighbourhoods, and slope in 1991. The results showed that the area under the ROC curve for MARS and ANN was 94.77% and 95.36%, respectively. Thus, ANN performed slightly better than MARS to simulate urban areas in Mumbai, India.

  8. Gamma-Ray Burst Dynamics and Afterglow Radiation from Adaptive Mesh Refinement, Special Relativistic Hydrodynamic Simulations

    Science.gov (United States)

    De Colle, Fabio; Granot, Jonathan; López-Cámara, Diego; Ramirez-Ruiz, Enrico

    2012-02-01

    We report on the development of Mezcal-SRHD, a new adaptive mesh refinement, special relativistic hydrodynamics (SRHD) code, developed with the aim of studying the highly relativistic flows in gamma-ray burst sources. The SRHD equations are solved using finite-volume conservative solvers, with second-order interpolation in space and time. The correct implementation of the algorithms is verified by one-dimensional (1D) and multi-dimensional tests. The code is then applied to study the propagation of 1D spherical impulsive blast waves expanding in a stratified medium with ρvpropr -k , bridging between the relativistic and Newtonian phases (which are described by the Blandford-McKee and Sedov-Taylor self-similar solutions, respectively), as well as to a two-dimensional (2D) cylindrically symmetric impulsive jet propagating in a constant density medium. It is shown that the deceleration to nonrelativistic speeds in one dimension occurs on scales significantly larger than the Sedov length. This transition is further delayed with respect to the Sedov length as the degree of stratification of the ambient medium is increased. This result, together with the scaling of position, Lorentz factor, and the shock velocity as a function of time and shock radius, is explained here using a simple analytical model based on energy conservation. The method used for calculating the afterglow radiation by post-processing the results of the simulations is described in detail. The light curves computed using the results of 1D numerical simulations during the relativistic stage correctly reproduce those calculated assuming the self-similar Blandford-McKee solution for the evolution of the flow. The jet dynamics from our 2D simulations and the resulting afterglow light curves, including the jet break, are in good agreement with those presented in previous works. Finally, we show how the details of the dynamics critically depend on properly resolving the structure of the relativistic flow.

  9. GAMMA-RAY BURST DYNAMICS AND AFTERGLOW RADIATION FROM ADAPTIVE MESH REFINEMENT, SPECIAL RELATIVISTIC HYDRODYNAMIC SIMULATIONS

    Energy Technology Data Exchange (ETDEWEB)

    De Colle, Fabio; Ramirez-Ruiz, Enrico [Astronomy and Astrophysics Department, University of California, Santa Cruz, CA 95064 (United States); Granot, Jonathan [Racah Institute of Physics, Hebrew University, Jerusalem 91904 (Israel); Lopez-Camara, Diego, E-mail: fabio@ucolick.org [Instituto de Ciencias Nucleares, Universidad Nacional Autonoma de Mexico, Ap. 70-543, 04510 D.F. (Mexico)

    2012-02-20

    We report on the development of Mezcal-SRHD, a new adaptive mesh refinement, special relativistic hydrodynamics (SRHD) code, developed with the aim of studying the highly relativistic flows in gamma-ray burst sources. The SRHD equations are solved using finite-volume conservative solvers, with second-order interpolation in space and time. The correct implementation of the algorithms is verified by one-dimensional (1D) and multi-dimensional tests. The code is then applied to study the propagation of 1D spherical impulsive blast waves expanding in a stratified medium with {rho}{proportional_to}r{sup -k}, bridging between the relativistic and Newtonian phases (which are described by the Blandford-McKee and Sedov-Taylor self-similar solutions, respectively), as well as to a two-dimensional (2D) cylindrically symmetric impulsive jet propagating in a constant density medium. It is shown that the deceleration to nonrelativistic speeds in one dimension occurs on scales significantly larger than the Sedov length. This transition is further delayed with respect to the Sedov length as the degree of stratification of the ambient medium is increased. This result, together with the scaling of position, Lorentz factor, and the shock velocity as a function of time and shock radius, is explained here using a simple analytical model based on energy conservation. The method used for calculating the afterglow radiation by post-processing the results of the simulations is described in detail. The light curves computed using the results of 1D numerical simulations during the relativistic stage correctly reproduce those calculated assuming the self-similar Blandford-McKee solution for the evolution of the flow. The jet dynamics from our 2D simulations and the resulting afterglow light curves, including the jet break, are in good agreement with those presented in previous works. Finally, we show how the details of the dynamics critically depend on properly resolving the structure of the

  10. USING MULTIVARIATE ADAPTIVE REGRESSION SPLINE AND ARTIFICIAL NEURAL NETWORK TO SIMULATE URBANIZATION IN MUMBAI, INDIA

    Directory of Open Access Journals (Sweden)

    M. Ahmadlou

    2015-12-01

    Full Text Available Land use change (LUC models used for modelling urban growth are different in structure and performance. Local models divide the data into separate subsets and fit distinct models on each of the subsets. Non-parametric models are data driven and usually do not have a fixed model structure or model structure is unknown before the modelling process. On the other hand, global models perform modelling using all the available data. In addition, parametric models have a fixed structure before the modelling process and they are model driven. Since few studies have compared local non-parametric models with global parametric models, this study compares a local non-parametric model called multivariate adaptive regression spline (MARS, and a global parametric model called artificial neural network (ANN to simulate urbanization in Mumbai, India. Both models determine the relationship between a dependent variable and multiple independent variables. We used receiver operating characteristic (ROC to compare the power of the both models for simulating urbanization. Landsat images of 1991 (TM and 2010 (ETM+ were used for modelling the urbanization process. The drivers considered for urbanization in this area were distance to urban areas, urban density, distance to roads, distance to water, distance to forest, distance to railway, distance to central business district, number of agricultural cells in a 7 by 7 neighbourhoods, and slope in 1991. The results showed that the area under the ROC curve for MARS and ANN was 94.77% and 95.36%, respectively. Thus, ANN performed slightly better than MARS to simulate urban areas in Mumbai, India.

  11. Adaptive coarse-grained Monte Carlo simulation of reaction and diffusion dynamics in heterogeneous plasma membranes

    Directory of Open Access Journals (Sweden)

    Stamatakis Michail

    2010-04-01

    Full Text Available Abstract Background An adaptive coarse-grained (kinetic Monte Carlo (ACGMC simulation framework is applied to reaction and diffusion dynamics in inhomogeneous domains. The presented model is relevant to the diffusion and dimerization dynamics of epidermal growth factor receptor (EGFR in the presence of plasma membrane heterogeneity and specifically receptor clustering. We perform simulations representing EGFR cluster dissipation in heterogeneous plasma membranes consisting of higher density clusters of receptors surrounded by low population areas using the ACGMC method. We further investigate the effect of key parameters on the cluster lifetime. Results Coarse-graining of dimerization, rather than of diffusion, may lead to computational error. It is shown that the ACGMC method is an effective technique to minimize error in diffusion-reaction processes and is superior to the microscopic kinetic Monte Carlo simulation in terms of computational cost while retaining accuracy. The low computational cost enables sensitivity analysis calculations. Sensitivity analysis indicates that it may be possible to retain clusters of receptors over the time scale of minutes under suitable conditions and the cluster lifetime may depend on both receptor density and cluster size. Conclusions The ACGMC method is an ideal platform to resolve large length and time scales in heterogeneous biological systems well beyond the plasma membrane and the EGFR system studied here. Our results demonstrate that cluster size must be considered in conjunction with receptor density, as they synergistically affect EGFR cluster lifetime. Further, the cluster lifetime being of the order of several seconds suggests that any mechanisms responsible for EGFR aggregation must operate on shorter timescales (at most a fraction of a second, to overcome dissipation and produce stable clusters observed experimentally.

  12. Simulation of Past Life: Controlling Agent Behaviors from the Interactions between Ethnic Groups

    OpenAIRE

    Lim, Chen Kim; Cani, Marie-Paule; Galvane, Quentin; Pettre, Julien; Talib, Abdullah Zawawi

    2013-01-01

    International audience Many efforts have been carried out in preserving the history and culture of Penang and also other regions of Malaysia since George Town was elected as a UNESCO living heritage city. This paper presents a method to simulate life in a local trading port in the 1800s, where various populations with very different social rules interacted with each other. These populations included Indian coolies, Malay vendors, British colonists and Chinese traders. The challenge is to m...

  13. A novel medical image data-based multi-physics simulation platform for computational life sciences

    OpenAIRE

    Neufeld, Esra; Szczerba, Dominik; Chavannes, Nicolas; Kuster, Niels

    2013-01-01

    Simulating and modelling complex biological systems in computational life sciences requires specialized software tools that can perform medical image data-based modelling, jointly visualize the data and computational results, and handle large, complex, realistic and often noisy anatomical models. The required novel solvers must provide the power to model the physics, biology and physiology of living tissue within the full complexity of the human anatomy (e.g. neuronal activity, perfusion and ...

  14. Turkish version of the chronic urticaria quality of life questionnaire: cultural adaptation, assessment of reliability and validity.

    Science.gov (United States)

    Kocatürk, Emek; Weller, Karsten; Martus, Peter; Aktas, Selin; Kavala, Mukaddes; Sarigul, Sükran; Baiardini, Ilaria; Canonica, Giorgio W; Brzoza, Zenon; Kalogeromitros, Dimitrios; Maurer, Marcus

    2012-07-01

    Chronic spontaneous urticaria has a substantial impact on patients' quality of life. The first disease-specific tool to assess quality of life impairment in this condition, the Chronic Urticaria Quality of Life Questionnaire (CU-Q2oL), was developed recently. The aim of this study was to adapt the original Italian version to the Turkish language and to evaluate its reliability, validity, and sensitivity to change. The Turkish version was developed by performing forward- and back-translation. It was then applied to 140 consecutive patients with chronic spontaneous urticaria, along with the Dermatology Life Quality Index and the Skindex-29. Disease activity was assessed using the Urticaria Activity Score. Sensitivity to change was measured in 101 patients, who completed the instruments twice at intervals of 4 weeks. Confirmatory factor analysis demonstrated that the six-scale structure of the original Italian version ("pruritus", "swelling", "impact on life activities", "sleep problems", "limits", "looks") can be retained in the Turkish instrument. Analysis regarding convergent validity showed good correlations of the Turkish CU-Q2oL with the other instruments. In addition, it was found to discriminate well between patients with different levels of urticaria activity, and to be sensitive to change. In conclusion, the Turkish version of CU-Q2oL is a reliable, valid, and sensitive instrument, which will help to characterize better the clinical impact of chronic spontaneous urticaria and treatment outcomes in Turkish patients. Its identical scale structure to that of other CU-Q2oL instruments makes it ideal for cross-cultural comparisons and for its application in future national and multinational studies. PMID:21918791

  15. Long-term effects of early life microbiota disturbance on adaptive immunity in laying hens.

    Science.gov (United States)

    Simon, K; Verwoolde, M B; Zhang, J; Smidt, H; de Vries Reilingh, G; Kemp, B; Lammers, A

    2016-07-01

    Due to an interplay between intestinal microbiota and immune system, disruption of intestinal microbiota composition during immune development may have consequences for immune responses later in life. The present study investigated the effects of antibiotic treatment in the first weeks of life on the specific antibody response later in life in chickens. Layer chicks received an antibiotic cocktail consisting of vancomycin, neomycin, metronidazole, and amphotericin-B by oral gavage every 12 h, and ampicillin and colistin in drinking water for the first week of life. After the first week of life, chicks received ampicillin and colistin in drinking water for two more weeks. Control birds received no antibiotic cocktail and plain drinking water. Fecal microbiota composition was determined during antibiotic treatment (d 8 and 22), two weeks after cessation of antibiotic treatment (d 36), and at the end of the experimental period at d 175 using a 16S ribosomal RNA gene targeted microarray, the Chicken Intestinal Tract Chip (ChickChip). During antibiotic treatment fecal microbiota composition differed strongly between treatment groups. Fecal microbiota of antibiotic treated birds consisted mainly of Proteobacteria, and in particular E.coli, whereas fecal microbiota of control birds consisted mainly of Firmicutes, such as lactobacilli and clostridia. Two weeks after cessation of antibiotic treatment fecal microbiota composition of antibiotic treated birds had recovered and was similar to that of control birds. On d 105, 12 weeks after cessation of antibiotic treatment, chicks of both treatment groups received an intra-tracheal lipopolysaccharide (LPS)/human serum albumin (HuSA) challenge. Antibody titers against LPS and HuSA were measured 10 days after administration of the challenge. While T cell independent antibody titers (LPS) were not affected by antibiotic treatment, antibiotic treated birds showed lower T cell dependent antibody titers (HuSA) compared with control

  16. MRI-based treatment plan simulation and adaptation for ion radiotherapy using a classification-based approach

    International Nuclear Information System (INIS)

    In order to benefit from the highly conformal irradiation of tumors in ion radiotherapy, sophisticated treatment planning and simulation are required. The purpose of this study was to investigate the potential of MRI for ion radiotherapy treatment plan simulation and adaptation using a classification-based approach. Firstly, a voxelwise tissue classification was applied to derive pseudo CT numbers from MR images using up to 8 contrasts. Appropriate MR sequences and parameters were evaluated in cross-validation studies of three phantoms. Secondly, ion radiotherapy treatment plans were optimized using both MRI-based pseudo CT and reference CT and recalculated on reference CT. Finally, a target shift was simulated and a treatment plan adapted to the shift was optimized on a pseudo CT and compared to reference CT optimizations without plan adaptation. The derivation of pseudo CT values led to mean absolute errors in the range of 81 - 95 HU. Most significant deviations appeared at borders between air and different tissue classes and originated from partial volume effects. Simulations of ion radiotherapy treatment plans using pseudo CT for optimization revealed only small underdosages in distal regions of a target volume with deviations of the mean dose of PTV between 1.4 - 3.1% compared to reference CT optimizations. A plan adapted to the target volume shift and optimized on the pseudo CT exhibited a comparable target dose coverage as a non-adapted plan optimized on a reference CT. We were able to show that a MRI-based derivation of pseudo CT values using a purely statistical classification approach is feasible although no physical relationship exists. Large errors appeared at compact bone classes and came from an imperfect distinction of bones and other tissue types in MRI. In simulations of treatment plans, it was demonstrated that these deviations are comparable to uncertainties of a target volume shift of 2 mm in two directions indicating that especially

  17. Scanning electron microscopy of Antarctophthirus microchir (Phthiraptera: Anoplura: Echinophthiriidae): studying morphological adaptations to aquatic life.

    Science.gov (United States)

    Leonardi, María Soledad; Crespo, Enrique A; Raga, Juan Antonio; Fernández, Mercedes

    2012-09-01

    The members of the Family Echinophthiriidae (Phthiraptera: Anoplura) are unique among insects because they infest hosts with an amphibious lifestyle. During their evolution they developed morphological traits that are reflected in unique features. The SEM is a helpful tool to analyze them. Knowing in detail the external structure of these lice is the first step to understand the whole process that derived from the co-adaptation of lice and pinnipeds to the marine environment. For the first time, we studied the external structure of all stages of an echinophthiriid louse. The results are discussed in the light of their evolutionary, functional, and ecological implications. PMID:22503484

  18. Life in the Fast Lane: The Evolution of an Adaptive Vehicle Control System

    OpenAIRE

    Jochem, Todd; Pomerleau, Dean

    1996-01-01

    Giving robots the ability to operate in the real world has been, and continues to be, one of the most difficult tasks in AI research. Since 1987, researchers at Carnegie Mellon University have been investigating one such task. Their research has been focused on using adaptive, vision-based systems to increase the driving performance of the Navlab line of on-road mobile robots. This research has led to the development of a neural network system that can learn to drive on many road types simply...

  19. Importance of leadership in cardiac arrest situations: from simulation to real life and back.

    Science.gov (United States)

    Hunziker, Sabnina; Tschan, Franziska; Semmer, Norbert K; Marsch, Stephan

    2013-04-18

    The 2010 American Heart Association guidelines now recommend leadership training in Advanced Cardiac Life Support courses. In this review we provide a comprehensive summary of data derived from clinical studies that investigated the importance of leadership in cardiopulmonary resuscitation (CPR). Only a few, mostly observational, studies have been conducted under real-life conditions because of the high heterogeneity of the situations, difficulties in capturing the initial phase of CPR, and ethical issues. Well-controlled studies in the human simulator can fill existing gaps and provide important insights. High-fidelity video-assisted simulator studies from different research groups have shown that a prolonged process of teambuilding is associated with significant shortcomings in CPR, whereas effective leadership improves team performance. In addition, randomised controlled studies have provided evidence that medical students receiving leadership training subsequently showed improved CPR performance, which was sustained after a follow up of 4 months. In addition, leadership is influenced by gender and other factors such as emotional stress. Future studies are needed to investigate cultural differences and how findings from the simulator can be transferred to real-life situations.

  20. "Grandeur in this view of life": N-body simulation models of the Galactic habitable zone

    CERN Document Server

    Vukotić, B; Martinez-Aviles, G; Ćirković, M M; Micic, M; Schindler, S

    2016-01-01

    We present an isolated Milky Way-like simulation in GADGET2 N-body SPH code. The Galactic disk star formation rate (SFR) surface densities and stellar mass indicative of Solar neighbourhood are used as thresholds to model the distribution of stellar mass in life friendly environments. SFR and stellar component density are calculated averaging the GADGET2 particle properties on a 2D grid mapped on the Galactic plane. The peak values for possibly habitable stellar mass surface density move from $10$ to $15$ kpc cylindrical galactocentric distance in $10$ Gyr simulated time span. At $10$ Gyr the simulation results imply the following. Stellar particles which have spent almost all of their life time in habitable friendly conditions reside typically at $\\sim16$ kpc from Galactic centre and are $\\sim 3$ Gyr old. Stellar particles that have spent $\\ge 90 \\%$ of their $4-5$ Gyr long life time in habitable friendly conditions, are also predominantly found in the outskirts of the Galactic disk. Less then $1 \\%$ of thes...

  1. Translation, Adaptation and Initial Validation of Food Allergy Quality of Life Questionnaire: Child form in Greek.

    Science.gov (United States)

    Morou, Zoe; Lyrakos, Georgios N; Papadopoulos, Nikolaos G; Douladiris, Nikolaos; Tatsioni, Athina; Dimoliatis, Ioannis D K

    2016-06-23

    The aim of the study is to determine the reliability and validity of the Greek version of the Food Allergy Quality of life Questionnaire-Child Form (FAQLQ-CF). After linguistic validation, the Greek FAQLQ-CF, Food Allergy Independent Measure (FAIM) and Pediatric Quality of Life Inventory (PedsQL™) were used by a physician to interview children diagnosed with food allergy and aged 8-12 via telephone. Cronbach's alpha was used to evaluate reliability, and factor analysis to assess construct validity. The correlation between FAQLQ-CF and FAIM was moderate (rho=0.509, P minimal clinical importance difference = 0.5; PGreek FAQLQ-CF is a reliable, valid, discriminant tool for interviewing food allergic children aged 8-12, detecting those in need for immediate care.

  2. Adaptation and validation of stroke-aphasia quality of life (SAQOL-39) scale to Hindi

    OpenAIRE

    Ishita H Mitra; Gopee Krishnan

    2015-01-01

    Background: Stroke is a major detriment to the quality of life (QOL) in its victims. Several functional limitations following stroke contribute to the denigrated QOL in this population. Aphasia, a disturbance in the comprehension, processing, and/or expression of language, is a common consequence of stroke. Yet, in most Indian languages, including the national language (Hindi), there are no published tools to measure the QOL of persons with stroke-aphasia. Objective: The current study was car...

  3. An adaptive algorithm for the detection of microcalcifications in simulated low-dose mammography

    Energy Technology Data Exchange (ETDEWEB)

    Treiber, O [Institute of Biomathematics and Biometry, GSF - National Research Center for Environment and Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg (Germany); Wanninger, F [Institute of Radiation Protection, GSF - National Research Center for Environment and Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg (Germany); Fuehr, H [Institute of Biomathematics and Biometry, GSF - National Research Center for Environment and Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg (Germany); Panzer, W [Institute of Radiation Protection, GSF - National Research Center for Environment and Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg (Germany); Regulla, D [Institute of Radiation Protection, GSF - National Research Center for Environment and Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg (Germany); Winkler, G [Institute of Biomathematics and Biometry, GSF - National Research Center for Environment and Health, Ingolstaedter Landstrasse 1, 85764 Neuherberg (Germany)

    2003-02-21

    This paper uses the task of microcalcification detection as a benchmark problem to assess the potential for dose reduction in x-ray mammography. We present the results of a newly developed algorithm for detection of microcalcifications as a case study for a typical commercial film-screen system (Kodak Min-R 2000/2190). The first part of the paper deals with the simulation of dose reduction for film-screen mammography based on a physical model of the imaging process. Use of a more sensitive film-screen system is expected to result in additional smoothing of the image. We introduce two different models of that behaviour, called moderate and strong smoothing. We then present an adaptive, model-based microcalcification detection algorithm. Comparing detection results with ground-truth images obtained under the supervision of an expert radiologist allows us to establish the soundness of the detection algorithm. We measure the performance on the dose-reduced images in order to assess the loss of information due to dose reduction. It turns out that the smoothing behaviour has a strong influence on detection rates. For moderate smoothing, a dose reduction by 25% has no serious influence on the detection results, whereas a dose reduction by 50% already entails a marked deterioration of the performance. Strong smoothing generally leads to an unacceptable loss of image quality. The test results emphasize the impact of the more sensitive film-screen system and its characteristics on the problem of assessing the potential for dose reduction in film-screen mammography. The general approach presented in the paper can be adapted to fully digital mammography.

  4. Object oriented structures for adaptive multilevel methods for flow simulation; Objektorientierte Strukturen fuer adaptive Multilevelverfahren zur Stroemungssimulation

    Energy Technology Data Exchange (ETDEWEB)

    Mueller, A.

    2000-09-01

    The dissertation investigates object-oriented structures on whose basis adaptive multilevel methods can be implemented. First, concepts for grid management, building of numeric structures and for representation and solution of the resulting systems of equations are discussed. These abstract concepts are then concretized on the basis of two examples. The first example is a standard FE discretization of a two-dimensional linear elliptic second order boundary value problem. The grid is refined adaptively using an a-posteriory error assessment element. The linear equation systems are solved by a multilevel preconditioned CG method. The second example is the solution of the three-dimensional, stationary incompressible Eulerian equations in a rotary coordinate system. Discretization takes place with the aid of a finite element developed by Rannacher and Turek on the basis of hexalaterial grids. The equation systems are solved using a nonlinear multigrid system. Local refining and a multilevel solution have been prepared. Test calculations show that the theory is practically applicable, e.g. to flow through hydraulic turbine rotors. [German] Die Dissertation befasst sich mit objektorientierten Strukturen, auf deren Basis sich adaptive Multilevelverfahren implementieren lassen. Zunaechst werden Konzepte zur Gitterverwaltung, zum Aufbau numerischer Strukturen und zur Darstellung sowie Loesung der resultierenden Gleichungssysteme erlaeutert. Anschliessend werden diese abstrakten Konzepte anhand zweier Beispiele konkretisiert. Das erste Beispiel betrifft die Standard Finite Elemente Diskretisierung eines zweidimensionalen linearen elliptischen Randwertproblems 2. Ordnung. Die Netzverfeinerung geschieht adaptiv mit Hilfe eines a-posteriori Fehlerschaetzers. Zur Loesung der linearen Gleichungssysteme wird ein multilevel vorkonditioniertes CG-Verfahren verwendet. Als zweites Beispiel dient die Loesung der dreidimensionalen, stationaeren, inkompressiblen Euler Gleichungen im

  5. Systematic testing of flood adaptation options in urban areas through simulations

    Science.gov (United States)

    Löwe, Roland; Urich, Christian; Sto. Domingo, Nina; Mark, Ole; Deletic, Ana; Arnbjerg-Nielsen, Karsten

    2016-04-01

    While models can quantify flood risk in great detail, the results are subject to a number of deep uncertainties. Climate dependent drivers such as sea level and rainfall intensities, population growth and economic development all have a strong influence on future flood risk, but future developments can only be estimated coarsely. In such a situation, robust decision making frameworks call for the systematic evaluation of mitigation measures against ensembles of potential futures. We have coupled the urban development software DAnCE4Water and the 1D-2D hydraulic simulation package MIKE FLOOD to create a framework that allows for such systematic evaluations, considering mitigation measures under a variety of climate futures and urban development scenarios. A wide spectrum of mitigation measures can be considered in this setup, ranging from structural measures such as modifications of the sewer network over local retention of rainwater and the modification of surface flow paths to policy measures such as restrictions on urban development in flood prone areas or master plans that encourage compact development. The setup was tested in a 300 ha residential catchment in Melbourne, Australia. The results clearly demonstrate the importance of considering a range of potential futures in the planning process. For example, local rainwater retention measures strongly reduce flood risk a scenario with moderate increase of rain intensities and moderate urban growth, but their performance strongly varies, yielding very little improvement in situations with pronounced climate change. The systematic testing of adaptation measures further allows for the identification of so-called adaptation tipping points, i.e. levels for the drivers of flood risk where the desired level of flood risk is exceeded despite the implementation of (a combination of) mitigation measures. Assuming a range of development rates for the drivers of flood risk, such tipping points can be translated into

  6. Geophysical astrophysical spectral-element adaptive refinement (GASpAR): Object-oriented h-adaptive fluid dynamics simulation

    Science.gov (United States)

    Rosenberg, Duane; Fournier, Aimé; Fischer, Paul; Pouquet, Annick

    2006-06-01

    An object-oriented geophysical and astrophysical spectral-element adaptive refinement (GASpAR) code is introduced. Like most spectral-element codes, GASpAR combines finite-element efficiency with spectral-method accuracy. It is also designed to be flexible enough for a range of geophysics and astrophysics applications where turbulence or other complex multiscale problems arise. The formalism accommodates both conforming and non-conforming elements. Several aspects of this code derive from existing methods, but here are synthesized into a new formulation of dynamic adaptive refinement (DARe) of non-conforming h-type. As a demonstration of the code, several new 2D test cases are introduced that have time-dependent analytic solutions and exhibit localized flow features, including the 2D Burgers equation with straight, curved-radial and oblique-colliding fronts. These are proposed as standard test problems for comparable DARe codes. Quantitative errors are reported for 2D spatial and temporal convergence of DARe.

  7. ADAPTATION OF THE HP LIFE PROGRAM FOR PROMOTION OF THE ENTREPRENEURSHIP AMONG YOUNG PEOPLE

    Directory of Open Access Journals (Sweden)

    Ivan Mihajlović

    2012-11-01

    Full Text Available This text is dealing with attempt of Management department, of Technical faculty in Bor, todevelop and further sustain the „entrepreneurial spirit“among young people. The subject of the paperis the HP LIFE program, in which Technical faculty in Bor is the only partner institution from Serbia.Besides up-to-date IT equipment obtained by Hewlett Packard in previous phases of this project,during 2012 this project was financially sustained by the Serbian institution „Centre for promotionof science“. This support will increase the scope of project activities during this year, including newtarget groups.

  8. Life cycle assessment of stormwater management in the context of climate change adaptation

    DEFF Research Database (Denmark)

    Brudler, Sarah; Arnbjerg-Nielsen, Karsten; Hauschild, Michael Zwicky;

    2016-01-01

    of different elements interacting to achieve desired safety levels. Typically, an economic assessment is carried out in the planning phase, while environmental sustainability is given little or no attention. In this paper, life cycle assessment is used to quantify environmental impacts of climate change...... in both alternatives. The uncertainty analysis shows the advantages of conducting an environmental assessment in the early stages of the planning process, when the design can still be optimised, but it also highlights the importance of detailed and site-specific data....

  9. Collembolan Transcriptomes Highlight Molecular Evolution of Hexapods and Provide Clues on the Adaptation to Terrestrial Life.

    Directory of Open Access Journals (Sweden)

    A Faddeeva

    Full Text Available Collembola (springtails represent a soil-living lineage of hexapods in between insects and crustaceans. Consequently, their genomes may hold key information on the early processes leading to evolution of Hexapoda from a crustacean ancestor.We assembled and annotated transcriptomes of the Collembola Folsomia candida and Orchesella cincta, and performed comparative analysis with protein-coding gene sequences of three crustaceans and three insects to identify adaptive signatures associated with the evolution of hexapods within the pancrustacean clade.Assembly of the springtail transcriptomes resulted in 37,730 transcripts with predicted open reading frames for F. candida and 32,154 for O. cincta, of which 34.2% were functionally annotated for F. candida and 38.4% for O. cincta. Subsequently, we predicted orthologous clusters among eight species and applied the branch-site test to detect episodic positive selection in the Hexapoda and Collembola lineages. A subset of 250 genes showed significant positive selection along the Hexapoda branch and 57 in the Collembola lineage. Gene Ontology categories enriched in these genes include metabolism, stress response (i.e. DNA repair, immune response, ion transport, ATP metabolism, regulation and development-related processes (i.e. eye development, neurological development.We suggest that the identified gene families represent processes that have played a key role in the divergence of hexapods within the pancrustacean clade that eventually evolved into the most species-rich group of all animals, the hexapods. Furthermore, some adaptive signatures in collembolans may provide valuable clues to understand evolution of hexapods on land.

  10. A general hybrid radiation transport scheme for star formation simulations on an adaptive grid

    International Nuclear Information System (INIS)

    Radiation feedback plays a crucial role in the process of star formation. In order to simulate the thermodynamic evolution of disks, filaments, and the molecular gas surrounding clusters of young stars, we require an efficient and accurate method for solving the radiation transfer problem. We describe the implementation of a hybrid radiation transport scheme in the adaptive grid-based FLASH general magnetohydrodyanmics code. The hybrid scheme splits the radiative transport problem into a raytracing step and a diffusion step. The raytracer captures the first absorption event, as stars irradiate their environments, while the evolution of the diffuse component of the radiation field is handled by a flux-limited diffusion solver. We demonstrate the accuracy of our method through a variety of benchmark tests including the irradiation of a static disk, subcritical and supercritical radiative shocks, and thermal energy equilibration. We also demonstrate the capability of our method for casting shadows and calculating gas and dust temperatures in the presence of multiple stellar sources. Our method enables radiation-hydrodynamic studies of young stellar objects, protostellar disks, and clustered star formation in magnetized, filamentary environments.

  11. A general hybrid radiation transport scheme for star formation simulations on an adaptive grid

    Energy Technology Data Exchange (ETDEWEB)

    Klassen, Mikhail; Pudritz, Ralph E. [Department of Physics and Astronomy, McMaster University 1280 Main Street W, Hamilton, ON L8S 4M1 (Canada); Kuiper, Rolf [Max Planck Institute for Astronomy Königstuhl 17, D-69117 Heidelberg (Germany); Peters, Thomas [Institut für Computergestützte Wissenschaften, Universität Zürich Winterthurerstrasse 190, CH-8057 Zürich (Switzerland); Banerjee, Robi; Buntemeyer, Lars, E-mail: klassm@mcmaster.ca [Hamburger Sternwarte, Universität Hamburg Gojenbergsweg 112, D-21029 Hamburg (Germany)

    2014-12-10

    Radiation feedback plays a crucial role in the process of star formation. In order to simulate the thermodynamic evolution of disks, filaments, and the molecular gas surrounding clusters of young stars, we require an efficient and accurate method for solving the radiation transfer problem. We describe the implementation of a hybrid radiation transport scheme in the adaptive grid-based FLASH general magnetohydrodyanmics code. The hybrid scheme splits the radiative transport problem into a raytracing step and a diffusion step. The raytracer captures the first absorption event, as stars irradiate their environments, while the evolution of the diffuse component of the radiation field is handled by a flux-limited diffusion solver. We demonstrate the accuracy of our method through a variety of benchmark tests including the irradiation of a static disk, subcritical and supercritical radiative shocks, and thermal energy equilibration. We also demonstrate the capability of our method for casting shadows and calculating gas and dust temperatures in the presence of multiple stellar sources. Our method enables radiation-hydrodynamic studies of young stellar objects, protostellar disks, and clustered star formation in magnetized, filamentary environments.

  12. Adaptive space warping to enhance passive haptics in an arthroscopy surgical simulator.

    Science.gov (United States)

    Spillmann, Jonas; Tuchschmid, Stefan; Harders, Matthias

    2013-04-01

    Passive haptics, also known as tactile augmentation, denotes the use of a physical counterpart to a virtual environment to provide tactile feedback. Employing passive haptics can result in more realistic touch sensations than those from active force feedback, especially for rigid contacts. However, changes in the virtual environment would necessitate modifications of the physical counterparts. In recent work space warping has been proposed as one solution to overcome this limitation. In this technique virtual space is distorted such that a variety of virtual models can be mapped onto one single physical object. In this paper, we propose as an extension adaptive space warping; we show how this technique can be employed in a mixed-reality surgical training simulator in order to map different virtual patients onto one physical anatomical model. We developed methods to warp different organ geometries onto one physical mock-up, to handle different mechanical behaviors of the virtual patients, and to allow interactive modifications of the virtual structures, while the physical counterparts remain unchanged. Various practical examples underline the wide applicability of our approach. To the best of our knowledge this is the first practical usage of such a technique in the specific context of interactive medical training.

  13. Simulated human eye retina adaptive optics imaging system based on a liquid crystal on silicon device

    Institute of Scientific and Technical Information of China (English)

    Jiang Bao-Guang; Cao Zhao-Liang; Mu Quan-Quan; Hu Li-Fa; Li Chao; Xuan Li

    2008-01-01

    In order to obtain a clear image of the retina of model eye, an adaptive optics system used to correct the wave-front error is introduced in this paper. The spatial light modulator that we use here is a liquid crystal on a silicon device instead of a conversional deformable mirror. A paper with carbon granule is used to simulate the retina of human eye. The pupil size of the model eye is adjustable (3-7 mm). A Shack-Hartman wave-front sensor is used to detect the wave-front aberration. With this construction, a value of peak-to-valley is achieved to be 0.086 λ, where A is wavelength.The modulation transfer functions before and after corrections are compared. And the resolution of this system after correction (691p/m) is very close to the diffraction limit resolution. The carbon granule on the white paper which has a size of 4.7μm is seen clearly. The size of the retina cell is between 4 and 10 μm. So this system has an ability to image the human eye's retina.

  14. EMMA: an adaptive mesh refinement cosmological simulation code with radiative transfer

    Science.gov (United States)

    Aubert, Dominique; Deparis, Nicolas; Ocvirk, Pierre

    2015-11-01

    EMMA is a cosmological simulation code aimed at investigating the reionization epoch. It handles simultaneously collisionless and gas dynamics, as well as radiative transfer physics using a moment-based description with the M1 approximation. Field quantities are stored and computed on an adaptive three-dimensional mesh and the spatial resolution can be dynamically modified based on physically motivated criteria. Physical processes can be coupled at all spatial and temporal scales. We also introduce a new and optional approximation to handle radiation: the light is transported at the resolution of the non-refined grid and only once the dynamics has been fully updated, whereas thermo-chemical processes are still tracked on the refined elements. Such an approximation reduces the overheads induced by the treatment of radiation physics. A suite of standard tests are presented and passed by EMMA, providing a validation for its future use in studies of the reionization epoch. The code is parallel and is able to use graphics processing units (GPUs) to accelerate hydrodynamics and radiative transfer calculations. Depending on the optimizations and the compilers used to generate the CPU reference, global GPU acceleration factors between ×3.9 and ×16.9 can be obtained. Vectorization and transfer operations currently prevent better GPU performance and we expect that future optimizations and hardware evolution will lead to greater accelerations.

  15. A memory structure adapted simulated annealing algorithm for a green vehicle routing problem.

    Science.gov (United States)

    Küçükoğlu, İlker; Ene, Seval; Aksoy, Aslı; Öztürk, Nursel

    2015-03-01

    Currently, reduction of carbon dioxide (CO2) emissions and fuel consumption has become a critical environmental problem and has attracted the attention of both academia and the industrial sector. Government regulations and customer demands are making environmental responsibility an increasingly important factor in overall supply chain operations. Within these operations, transportation has the most hazardous effects on the environment, i.e., CO2 emissions, fuel consumption, noise and toxic effects on the ecosystem. This study aims to construct vehicle routes with time windows that minimize the total fuel consumption and CO2 emissions. The green vehicle routing problem with time windows (G-VRPTW) is formulated using a mixed integer linear programming model. A memory structure adapted simulated annealing (MSA-SA) meta-heuristic algorithm is constructed due to the high complexity of the proposed problem and long solution times for practical applications. The proposed models are integrated with a fuel consumption and CO2 emissions calculation algorithm that considers the vehicle technical specifications, vehicle load, and transportation distance in a green supply chain environment. The proposed models are validated using well-known instances with different numbers of customers. The computational results indicate that the MSA-SA heuristic is capable of obtaining good G-VRPTW solutions within a reasonable amount of time by providing reductions in fuel consumption and CO2 emissions. PMID:25056743

  16. A brief report on an action learning group exploration of how older people adapt to change in later life

    Directory of Open Access Journals (Sweden)

    Francis C. Biley

    2011-12-01

    Full Text Available In collaboration with Age Concern UK, older people were invited to participate in action learning groups to explore how they adapt to change. Themes for discussion were initially identified using a nominal focus method. Discussions identified actual and desired methods of coping with changes in later life. A series of weekly meetings with three cohorts of urban, rural and sheltered accommodation participants with an average age of 81 years revealed that they were concerned with having to cope with and adapt to a wide range of experiences. These included the loss of sharing and reduced sociability, reduced mobility, bereavement, physical changes, having to move house and/or location, having to retire, and having to deal with outside agencies. In order to cope with these experiences, participants engaged in a range of activities that centered on aspects of communication and social networking. Participants talked to each other socially and informally, exchanging information and advice. When able, they also participated in more structured but non-specific social events during which time they also had the opportunity to support each other. Participants suggested that there was a role for statutory and nonstatutory bodies and professions such as mental health and community adult nursing, occupational therapy and social work to provide more formal social networking and information exchange opportunities.

  17. Effect of adapted karate training on quality of life and body balance in 50-year-old men

    Directory of Open Access Journals (Sweden)

    Marie-Ludivine Chateau-Degat

    2010-08-01

    Full Text Available Marie-Ludivine Chateau-Degat1, Gérard Papouin2, Philippe Saint-Val3, Antonio Lopez21Axe sante des populations et environmentale, CHUQ, Laval University, Quebec, Canada; 2Service de Cardiologie, Centre Hospitalier Territorial du Taone, 3Fédération Tahitienne de Karaté, Papeete, French PolynesiaBackground: Aging is associated with a decrease in physical skills, sometimes accompanied by a change in quality of life (QOL. Long-term martial arts practice has been proposed as an avenue to counter these deleterious effects. The general purpose of this pilot study was to identify the effects of an adapted karate training program on QOL, depression, and motor skills in 50-year-old men.Methods and design: Fifteen 50-year-old men were enrolled in a one-year prospective experiment. Participants practiced adapted karate training for 90 minutes three times a week. Testing sessions, involving completion of the MOS 36-item Short Form Health Survey (SF36 and Beck Depression Inventory, as well as motor and effort evaluation, were done at baseline, and six and 12 months.Results: Compared with baseline, participants had better Beck Depression Inventory scores after one year of karate training (P < 0.01 and better perception of their physical health (P < 0.01, but not on the mental dimension (P < 0.49. They also improved their reaction time scores for the nondominant hand and sway parameters in the eyes-closed position (P < 0.01.Conclusion: Regular long-term karate practice had favorable effects on mood, perception of physical health confirmed by better postural control, and improved performance on objective physical testing. Adapted karate training would be an interesting option for maintaining physical activity in aging.Keywords: karate, balance, training, sport, aging

  18. Advancing adaptive optics technology: Laboratory turbulence simulation and optimization of laser guide stars

    Science.gov (United States)

    Rampy, Rachel A.

    Since Galileo's first telescope some 400 years ago, astronomers have been building ever-larger instruments. Yet only within the last two decades has it become possible to realize the potential angular resolutions of large ground-based telescopes, by using adaptive optics (AO) technology to counter the blurring effects of Earth's atmosphere. And only within the past decade have the development of laser guide stars (LGS) extended AO capabilities to observe science targets nearly anywhere in the sky. Improving turbulence simulation strategies and LGS are the two main topics of my research. In the first part of this thesis, I report on the development of a technique for manufacturing phase plates for simulating atmospheric turbulence in the laboratory. The process involves strategic application of clear acrylic paint onto a transparent substrate. Results of interferometric characterization of the plates are described and compared to Kolmogorov statistics. The range of r0 (Fried's parameter) achieved thus far is 0.2--1.2 mm at 650 nm measurement wavelength, with a Kolmogorov power law. These plates proved valuable at the Laboratory for Adaptive Optics at University of California, Santa Cruz, where they have been used in the Multi-Conjugate Adaptive Optics testbed, during integration and testing of the Gemini Planet Imager, and as part of the calibration system of the on-sky AO testbed named ViLLaGEs (Visible Light Laser Guidestar Experiments). I present a comparison of measurements taken by ViLLaGEs of the power spectrum of a plate and the real sky turbulence. The plate is demonstrated to follow Kolmogorov theory well, while the sky power spectrum does so in a third of the data. This method of fabricating phase plates has been established as an effective and low-cost means of creating simulated turbulence. Due to the demand for such devices, they are now being distributed to other members of the AO community. The second topic of this thesis pertains to understanding and

  19. Family Wide Molecular Adaptations to Underground Life in African Mole-Rats Revealed by Phylogenomic Analysis.

    Science.gov (United States)

    Davies, Kalina T J; Bennett, Nigel C; Tsagkogeorga, Georgia; Rossiter, Stephen J; Faulkes, Christopher G

    2015-12-01

    During their evolutionary radiation, mammals have colonized diverse habitats. Arguably the subterranean niche is the most inhospitable of these, characterized by reduced oxygen, elevated carbon dioxide, absence of light, scarcity of food, and a substrate that is energetically costly to burrow through. Of all lineages to have transitioned to a subterranean niche, African mole-rats are one of the most successful. Much of their ecological success can be attributed to a diet of plant storage organs, which has allowed them to colonize climatically varied habitats across sub-Saharan Africa, and has probably contributed to the evolution of their diverse social systems. Yet despite their many remarkable phenotypic specializations, little is known about molecular adaptations underlying these traits. To address this, we sequenced the transcriptomes of seven mole-rat taxa, including three solitary species, and combined new sequences with existing genomic data sets. Alignments of more than 13,000 protein-coding genes encompassed, for the first time, all six genera and the full spectrum of ecological and social variation in the clade. We detected positive selection within the mole-rat clade and along ancestral branches in approximately 700 genes including loci associated with tumorigenesis, aging, morphological development, and sociality. By combining these results with gene ontology annotation and protein-protein networks, we identified several clusters of functionally related genes. This family wide analysis of molecular evolution in mole-rats has identified a suite of positively selected genes, deepening our understanding of the extreme phenotypic traits exhibited by this group.

  20. Life at the border: Adaptation of proteins to anisotropic membrane environment

    Science.gov (United States)

    Pogozheva, Irina D; Mosberg, Henry I; Lomize, Andrei L

    2014-01-01

    This review discusses main features of transmembrane (TM) proteins which distinguish them from water-soluble proteins and allow their adaptation to the anisotropic membrane environment. We overview the structural limitations on membrane protein architecture, spatial arrangement of proteins in membranes and their intrinsic hydrophobic thickness, co-translational and post-translational folding and insertion into lipid bilayers, topogenesis, high propensity to form oligomers, and large-scale conformational transitions during membrane insertion and transport function. Special attention is paid to the polarity of TM protein surfaces described by profiles of dipolarity/polarizability and hydrogen-bonding capacity parameters that match polarity of the lipid environment. Analysis of distributions of Trp resides on surfaces of TM proteins from different biological membranes indicates that interfacial membrane regions with preferential accumulation of Trp indole rings correspond to the outer part of the lipid acyl chain region—between double bonds and carbonyl groups of lipids. These “midpolar” regions are not always symmetric in proteins from natural membranes. We also examined the hydrophobic effect that drives insertion of proteins into lipid bilayer and different free energy contributions to TM protein stability, including attractive van der Waals forces and hydrogen bonds, side-chain conformational entropy, the hydrophobic mismatch, membrane deformations, and specific protein–lipid binding. PMID:24947665

  1. The Application of Virtual Simulations using Second Life in a Foreign Language Classroom

    Directory of Open Access Journals (Sweden)

    Tecnam Yoon

    2014-02-01

    Full Text Available The purpose of this paper is to investigate the effects of virtual simulation-based language learning in a foreign language class in Korea. Total 35 1st-year university students in Korea participated in this research to figure out the effect of simulations. A virtual English learning community, ‘Cypris Chat’ in Second Life was selected as a learning tool. For the data collection, a survey questionnaire was distributed and analysed quantitatively. The result shows that the majority of the students had a positive attitude toward using a virtual simulation in English learning and had better understanding in learning English by experiencing an authentic practice. The first section of this paper provides a general overview of simulations in educational settings through an insightful literature review of the current research in the area. The review includes a comprehensive outlook on simulations, an example of successful classroom integration and some of the considerations researchers have found for their implementation. The latter section addresses the research method, results and conclusions.

  2. The performance of field scientists undertaking observations of early life fossils while in simulated space suit

    Science.gov (United States)

    Willson, D.; Rask, J. C.; George, S. C.; de Leon, P.; Bonaccorsi, R.; Blank, J.; Slocombe, J.; Silburn, K.; Steele, H.; Gargarno, M.; McKay, C. P.

    2014-01-01

    We conducted simulated Apollo Extravehicular Activity's (EVA) at the 3.45 Ga Australian 'Pilbara Dawn of life' (Western Australia) trail with field and non-field scientists using the University of North Dakota's NDX-1 pressurizable space suit to overview the effectiveness of scientist astronauts employing their field observation skills while looking for stromatolite fossil evidence. Off-world scientist astronauts will be faced with space suit limitations in vision, human sense perception, mobility, dexterity, the space suit fit, time limitations, and the psychological fear of death from accidents, causing physical fatigue reducing field science performance. Finding evidence of visible biosignatures for past life such as stromatolite fossils, on Mars, is a very significant discovery. Our preliminary overview trials showed that when in simulated EVAs, 25% stromatolite fossil evidence is missed with more incorrect identifications compared to ground truth surveys but providing quality characterization descriptions becomes less affected by simulated EVA limitations as the science importance of the features increases. Field scientists focused more on capturing high value characterization detail from the rock features whereas non-field scientists focused more on finding many features. We identified technologies and training to improve off-world field science performance. The data collected is also useful for NASA's "EVA performance and crew health" research program requirements but further work will be required to confirm the conclusions.

  3. Improving advanced cardiovascular life support skills in medical students: simulation-based education approach

    Directory of Open Access Journals (Sweden)

    Hamidreza Reihani

    2015-01-01

    Full Text Available Objective: In this trial, we intend to assess the effect of simulation-based education approach on advanced cardiovascular life support skills among medical students. Methods: Through convenient sampling method, 40 interns of Mashhad University of Medical Sciences in their emergency medicine rotation (from September to December 2012 participated in this study. Advanced Cardiovascular Life Support (ACLS workshops with pretest and post-test exams were performed. Workshops and checklists for pretest and post-test exams were designed according to the latest American Heart Association (AHA guidelines. Results: The total score of the students increased significantly after workshops (24.6 out of 100 to 78.6 out of 100. This demonstrates 53.9% improvement in the skills after the simulation-based education (P< 0.001. Also the mean score of each station had a significant improvement (P< 0.001. Conclusion: Pretests showed that interns had poor performance in practical clinical matters while their scientific knowledge, such as ECG interpretation was acceptable. The overall results of the study highlights that Simulation based-education approach is highly effective in Improving ACLS skills among medical students.

  4. The canonical equation of adaptive dynamics for life histories: from fitness-returns to selection gradients and Pontryagin's maximum principle.

    Science.gov (United States)

    Metz, Johan A Jacob; Staňková, Kateřina; Johansson, Jacob

    2016-03-01

    This paper should be read as addendum to Dieckmann et al. (J Theor Biol 241:370-389, 2006) and Parvinen et al. (J Math Biol 67: 509-533, 2013). Our goal is, using little more than high-school calculus, to (1) exhibit the form of the canonical equation of adaptive dynamics for classical life history problems, where the examples in Dieckmann et al. (J Theor Biol 241:370-389, 2006) and Parvinen et al. (J Math Biol 67: 509-533, 2013) are chosen such that they avoid a number of the problems that one gets in this most relevant of applications, (2) derive the fitness gradient occurring in the CE from simple fitness return arguments, (3) show explicitly that setting said fitness gradient equal to zero results in the classical marginal value principle from evolutionary ecology, (4) show that the latter in turn is equivalent to Pontryagin's maximum principle, a well known equivalence that however in the literature is given either ex cathedra or is proven with more advanced tools, (5) connect the classical optimisation arguments of life history theory a little better to real biology (Mendelian populations with separate sexes subject to an environmental feedback loop), (6) make a minor improvement to the form of the CE for the examples in Dieckmann et al. and Parvinen et al.

  5. Assessing the performance of life-cycle portfolio allocation strategies for retirement saving: a simulation study.

    Science.gov (United States)

    Bridges, Benjamin; Gesumaria, Robert; Leonesio, Michael V

    2010-01-01

    This article examines the performance of four life-cycle portfolio allocation strategies through stochastic simulation based on observed U.S. asset returns during 1926-2008. Annual worker contributions to retirement savings accounts are based on the actual lifetime earnings histories maintained by the Social Security Administration for 12,871 workers born during 1915-1942. Each strategy's performance is evaluated primarily on the basis of the distributions of internal rates of return on investments calculated at the time of retirement. Comparisons are made with the performance of four other investment strategies that vary in terms of their exposure to stock and bond market risk. Life-cycle plans with larger portfolio weights assigned to equities have higher average returns, but those gains come at the cost of increased risk of infrequent bad outcomes.

  6. Comparison of Fatigue Life Estimation Using Equivalent Linearization and Time Domain Simulation Methods

    Science.gov (United States)

    Mei, Chuh; Dhainaut, Jean-Michel

    2000-01-01

    The Monte Carlo simulation method in conjunction with the finite element large deflection modal formulation are used to estimate fatigue life of aircraft panels subjected to stationary Gaussian band-limited white-noise excitations. Ten loading cases varying from 106 dB to 160 dB OASPL with bandwidth 1024 Hz are considered. For each load case, response statistics are obtained from an ensemble of 10 response time histories. The finite element nonlinear modal procedure yields time histories, probability density functions (PDF), power spectral densities and higher statistical moments of the maximum deflection and stress/strain. The method of moments of PSD with Dirlik's approach is employed to estimate the panel fatigue life.

  7. Design and Simulation of a Smart Home managed by an Intelligent Self-Adaptive System

    Directory of Open Access Journals (Sweden)

    Basman M. Hasan Alhafidh

    2016-08-01

    Full Text Available Home automation and control systems as basic elements of smart cities have played a key role in the development of our homes environments. They have a wide range of applications in many fields at home such as security and monitoring, healthcare, energy, and entertainment applications. The improvement of humans’ living standards make people keep trying to delegate many of their needs to a home automation system. Such a system has been built with capabilities of predicting what the user intends to do in smart home environment. However, there are many issues that need more investigation and solutions, such as: 1 many researches adopt a specific application without integrating different varieties of applications in one environment, 2 there is no study tries to show the real effect or even evaluates the implementation of predicted actions that have been established via homes intelligent gateway, 3 there is an interoperability issue due to using different kinds of home applications that have different protocols for message context. In this proposal, we will describe a new approach of an intelligent self-adaptive system that can precisely monitor a stakeholder behaviors and analyze his/her actions trying to anticipate a stakeholder behavior in the future. In addition, we will evaluate the real effect of a predicted actions after implementing them by an intelligent gateway in a simulated home environment. The principle behind a prediction process is presented by analyzing a sequence of user’s interaction events with heterogeneous, and distributed nodes in the environment using an intelligent gateway. Predicting next stakeholder action can be process using certain analytical algorithms. The main novelties in the proposed approach are threefold: I Developing a learning technique which is embedded in an intelligent gateway to build a model of users’ behavior and interactions to balance the needs of multiple users within a smart home environment. II

  8. Sensitivity and adaptability of methanogens to perchlorates: Implications for life on Mars

    Science.gov (United States)

    Kral, Timothy A.; Goodhart, Timothy H.; Harpool, Joshua D.; Hearnsberger, Christopher E.; McCracken, Graham L.; McSpadden, Stanley W.

    2016-01-01

    % indicating some success in adapting cells to concentrations higher than 1%. The results reported here indicate that the presence of perchlorate on Mars does not rule out the possible existence of methanogens.

  9. SOCIAL ADAPTABILITY OF YOUNG PEOPLE WITH MENTAL DISABILITIES FOR INDEPENDENT LIFE IN SOCIETY: ESSENCE, SPECIFICITY, LEVELS OF EXISTENCE, CRITERIA AND INDICATORS FOR THEIR EVALUATION

    Directory of Open Access Journals (Sweden)

    Veronika Grebennikova

    2015-01-01

    Full Text Available This article was prepared within the framework of the state assignment of the Ministry of education and science of the Russian Federation No. 3307 In the article the authors explain the nature and content of social adaptability of graduates psycho-neurological boarding schools (young people with disabilities from 24 to 27 years old with mild mental retardation to independent life in society; note that this adaptability is characterized by the level of proficiency of graduate boarding norms of social behavior, professional orientation and socio-moral experience of self in different situations. Reveal the content of main components (motivational, cognitive, activity that determine the social adaptability of the graduate psycho-neurological boarding school; lead characteristics of the levels of formation of social adaptability of graduates of psycho-neurological boarding schools for independent living (minimal-basic level; socially stable level; social perspective level. Also, the authors consider the principles of implementation of socio-pedagogical support of adaptation of graduates of the boarding school to independent life in society (in particular, the principle of the humanistic nature of the relationship specialists of psycho-neurological boarding schools with young people with disabilities; the principle of individual approach; the principle of variability and complexity of forms, methods, means of support; the principle of the priority of the interests of professional and personal development of a young disabled person in the implementation of socio-pedagogical support of its adaptation to independent life in society, etc..

  10. Cross-cultural adaptation and initial validation of the Stroke-Specific Quality of Life Scale into the Yoruba language.

    Science.gov (United States)

    Akinpelu, Aderonke O; Odetunde, Marufat O; Odole, Adesola C

    2012-12-01

    Stroke-Specific Quality of Life 2.0 (SS-QoL 2.0) scale is used widely and has been cross-culturally adapted to many languages. This study aimed at the cross-cultural adaptation of SS-QoL 2.0 to Yoruba, the indigenous language of south-western Nigeria, and to carry out an initial investigation on its validity. English SS-QoL 2.0 was first adapted to Yoruba language by including Yoruba culture-specific examples in items SC4, UE2 and UE6. The adapted English version (AEV) was independently translated into Yoruba by two language experts who later agreed on a consensus translation, which was then back translated, subjected to an expert committee review and pretested; a cognitive debriefing interview was also carried out to generate the Yoruba translated version (YTV). Thirty-five stroke survivors completed the AEV and Yoruba version (YV) in English and Yoruba. The order of administration was randomized. Data were analysed using Spearman's rank order correlation and Wilcoxon's signed-rank test at a P value less than 0.05. The mean age of the participants (23 men, 12 women) was 58.5±11.3 years. The domain scores of the participants on AEV and YV did not differ significantly, except in the work/productivity domain. In both versions, the mean domain score of the participants was the highest in the language domain [22.6±3.8 (AEV) and 22.7±3.4 (YV)] and the lowest in the work domain [9.0±3.7 (AEV) and 8.0±3.3 (YTV)]. Domain scores on both versions correlated significantly (P<0.05). Participants' ratings of their current state and prestroke state correlated significantly (P<0.01) in all the general areas, except energy and mood. The YTV of SS-QoL 2.0 fulfilled the initial criteria for validity.

  11. Adaptive coupling between damage mechanics and peridynamics: a route for objective simulation of material degradation up to complete failure

    KAUST Repository

    Han, Fei

    2016-05-17

    The objective (mesh-independent) simulation of evolving discontinuities, such as cracks, remains a challenge. Current techniques are highly complex or involve intractable computational costs, making simulations up to complete failure difficult. We propose a framework as a new route toward solving this problem that adaptively couples local-continuum damage mechanics with peridynamics to objectively simulate all the steps that lead to material failure: damage nucleation, crack formation and propagation. Local-continuum damage mechanics successfully describes the degradation related to dispersed microdefects before the formation of a macrocrack. However, when damage localizes, it suffers spurious mesh dependency, making the simulation of macrocracks challenging. On the other hand, the peridynamic theory is promising for the simulation of fractures, as it naturally allows discontinuities in the displacement field. Here, we present a hybrid local-continuum damage/peridynamic model. Local-continuum damage mechanics is used to describe “volume” damage before localization. Once localization is detected at a point, the remaining part of the energy is dissipated through an adaptive peridynamic model capable of the transition to a “surface” degradation, typically a crack. We believe that this framework, which actually mimics the real physical process of crack formation, is the first bridge between continuum damage theories and peridynamics. Two-dimensional numerical examples are used to illustrate that an objective simulation of material failure can be achieved by this method.

  12. Adaptive coupling between damage mechanics and peridynamics: A route for objective simulation of material degradation up to complete failure

    Science.gov (United States)

    Han, Fei; Lubineau, Gilles; Azdoud, Yan

    2016-09-01

    The objective (mesh-independent) simulation of evolving discontinuities, such as cracks, remains a challenge. Current techniques are highly complex or involve intractable computational costs, making simulations up to complete failure difficult. We propose a framework as a new route toward solving this problem that adaptively couples local-continuum damage mechanics with peridynamics to objectively simulate all the steps that lead to material failure: damage nucleation, crack formation and propagation. Local-continuum damage mechanics successfully describes the degradation related to dispersed microdefects before the formation of a macrocrack. However, when damage localizes, it suffers spurious mesh dependency, making the simulation of macrocracks challenging. On the other hand, the peridynamic theory is promising for the simulation of fractures, as it naturally allows discontinuities in the displacement field. Here, we present a hybrid local-continuum damage/peridynamic model. Local-continuum damage mechanics is used to describe "volume" damage before localization. Once localization is detected at a point, the remaining part of the energy is dissipated through an adaptive peridynamic model capable of the transition to a "surface" degradation, typically a crack. We believe that this framework, which actually mimics the real physical process of crack formation, is the first bridge between continuum damage theories and peridynamics. Two-dimensional numerical examples are used to illustrate that an objective simulation of material failure can be achieved by this method.

  13. Simulation to track 3D location in GSM through NS2 and real life

    CERN Document Server

    Gupta, Anand; Bosco, MS Don; Shashidhar, Vinay; 10.5121/jgraphhoc.2010.2103

    2010-01-01

    In recent times the cost of mobile communication has dropped significantly leading to a dramatic increase in mobile phone usage. The widespread usage has led mobiles to emerge as a strong alternative for other applications one of which is tracking. This has enabled law-enforcing agencies to detect overspeeding vehicles and organizations to keep track its employees. The 3 major ways of tracking being employed presently are (a) via GPS [1] (b) signal attenuation property of a packet [3] and (c) using GSM Network [2]. The initial cost of GPS is very high resulting in low usage whereas (b) needs a very high precision measuring device. The paper presents a GSM-based tracking technique which eliminates the above mentioned overheads, implements it in NS2 and shows the limitations of the real life simulation. An accuracy of 97% was achieved during NS2 simulation which is comparable to the above mentioned alternate methods of tracking.

  14. Simulation to track 3D location in GSM through NS2 and real life

    Directory of Open Access Journals (Sweden)

    Anand Gupta

    2010-03-01

    Full Text Available In recent times the cost of mobile communication has dropped significantly leading to a dramaticincrease in mobile phone usage. The widespread usage has led mobiles to emerge as a strong alternativefor other applications one of which is tracking. This has enabled law-enforcing agencies to detect overspeedingvehicles and organizations to keep track its employees. The 3 major ways of tracking beingemployed presently are (a via GPS [1] (b signal attenuation property of a packet [3] and (c using GSMNetwork [2]. The initial cost of GPS is very high resulting in low usage whereas (b needs a very highprecision measuring device. The paper presents a GSM-based tracking technique which eliminates theabove mentioned overheads, implements it in NS2 and shows the limitations of the real life simulation. Anaccuracy of 97% was achieved during NS2 simulation which is comparable to the above mentionedalternate methods of tracking.

  15. Biogenic hydrogen peroxide as a possible adaptation of life on Mars: the search for biosignatures

    Science.gov (United States)

    Houtkooper, J. M.; Schulze-Makuch, D.

    2007-08-01

    The hypothesis that putative Martian organisms incorporate H2O2 into their intracellular liquids (Houtkooper and Schulze-Makuch, 2007) has significant implications, as it explains the Viking observations quite well; it provides a functional adaptation to Martian environmental conditions; and, it is feasible as an adaptation based on the biochemistry of terrestrial organisms. It would explain many of the puzzling Viking observations such as (1) the lack of organics detected by GC-MS, (2) the lack of detected oxidant(s) to support a chemical explanation, (3) evolution of O2 upon wetting (GEx experiment), (4) limited organic synthesis reactions (PR experiment), and (5) the gas release observations made (LR experiment). An intracellular liquid containing a high concentration of H2O2 has advantages such as providing a low freezing point, a source of oxygen, and hygroscopicity, allowing an organism to obtain water vapor from the Martian atmosphere or from the adsorbed layers of water molecules on mineral grains. Perhaps surprisingly, H2O2 is used by many terrestrial organisms for diverse purposes, e.g., metabolism (Acetobacter peroxidans), as defense mechanism (Bombardier beetle), and also to mediate diverse physiological responses such as cell proliferation, differentiation, and migration. The detection of H2O2-containing organisms may well suffer from the same problems as the Viking experiments: Because of the excess oxidative contents, as derived from the GEx experiment, the organisms may decompose completely into H2O, CO2, O2 and N2. This can happen when exposed to an excess of water vapor (through hyperhydration), too high a temperature or a combination of both. Therefore, the addition of too much water vapor may be fatal. Moreover, employing pyrolysis in order to detect organic molecules may result in the organisms autooxidizing completely. Although the instrument suite aboard the Phoenix Lander offers some interesting possibilities (Schulze-Makuch and Houtkooper

  16. Adaptive Mesh Refinement Cosmological Simulations of Cosmic Rays in Galaxy Clusters

    Science.gov (United States)

    Skillman, Samuel William

    2013-12-01

    Galaxy clusters are unique astrophysical laboratories that contain many thermal and non-thermal phenomena. In particular, they are hosts to cosmic shocks, which propagate through the intracluster medium as a by-product of structure formation. It is believed that at these shock fronts, magnetic field inhomogeneities in a compressing flow may lead to the acceleration of cosmic ray electrons and ions. These relativistic particles decay and radiate through a variety of mechanisms, and have observational signatures in radio, hard X-ray, and Gamma-ray wavelengths. We begin this dissertation by developing a method to find shocks in cosmological adaptive mesh refinement simulations of structure formation. After describing the evolution of shock properties through cosmic time, we make estimates for the amount of kinetic energy processed and the total number of cosmic ray protons that could be accelerated at these shocks. We then use this method of shock finding and a model for the acceleration of and radio synchrotron emission from cosmic ray electrons to estimate the radio emission properties in large scale structures. By examining the time-evolution of the radio emission with respect to the X-ray emission during a galaxy cluster merger, we find that the relative timing of the enhancements in each are important consequences of the shock dynamics. By calculating the radio emission expected from a given mass galaxy cluster, we make estimates for future large-area radio surveys. Next, we use a state-of-the-art magnetohydrodynamic simulation to follow the electron acceleration in a massive merging galaxy cluster. We use the magnetic field information to calculate not only the total radio emission, but also create radio polarization maps that are compared to recent observations. We find that we can naturally reproduce Mpc-scale radio emission that resemble many of the known double radio relic systems. Finally, motivated by our previous studies, we develop and introduce a

  17. Adaptive local refinement and multi-level methods for simulating multiphasic flows

    International Nuclear Information System (INIS)

    This thesis describes some numerical and mathematical aspects of incompressible multiphase flows simulations with a diffuse interface Cahn-Hilliard / Navier-Stokes model (interfaces have a small but a positive thickness). The space discretization is performed thanks to a Galerkin formulation and the finite elements method. The presence of different scales in the system (interfaces have a very small thickness compared to the characteristic lengths of the domain) suggests the use of a local adaptive refinement method. The algorithm that is introduced allows to implicitly handle the non-conformities of the generated meshes to produce conformal finite elements approximation spaces. It consists in refining basis functions instead of cells. The refinement of a basis function is made possible by the conceptual existence of a nested sequence of uniformly refined grids from which 'parent-child' relationships are deduced, linking the basis functions of two consecutive refinement levels. Moreover, it is shown how this method can be exploited to build multigrid pre-conditioners. From a composite finite elements approximation space, it is indeed possible to rebuild, by 'coarsening', a sequence of auxiliary nested spaces which allows to enter in the abstract multigrid framework. Concerning the time discretization, it begins with the study of the Cahn-Hilliard system. A semi-implicit scheme is proposed to remedy to convergence failures of the Newton method used to solve this (non linear) system. It guarantees the decrease of the discrete free energy ensuring the stability of the scheme. The existence and convergence of discrete solutions towards the weak solution of the system are shown. The study continues with providing an unconditionally stable time discretization of the complete Cahn-Hilliard / Navier-Stokes model. An important point is that this discretization does not strongly couple the Cahn-Hilliard and Navier-Stokes systems allowing to independently solve the two systems

  18. The impact of a simulated intervention on attitudes of undergraduate nursing and medical students towards end of life care provision

    OpenAIRE

    Lewis, Claire; Reid, Joanne; McLernon, Zara; Ingham, Rory; Traynor, Mary

    2016-01-01

    Background: The concerns of undergraduate nursing and medical students’ regarding end of life care are well documented. Many report feelings of emotional distress, anxiety and a lack of preparation to provide care to patients at end of life and their families. Evidence suggests that increased exposure to patients who are dying and their families can improve attitudes toward end of life care. In the absence of such clinical exposure, simulation provides experiential learning with outcomes comp...

  19. Effect of Advanced Trauma Life Support program on medical interns' performance in simulated trauma patient management

    Directory of Open Access Journals (Sweden)

    Ahmadi Koorosh

    2013-06-01

    Full Text Available 【Abstract】Objective: Since appropriate and time-table methods in trauma care have an important impact on patients’ outcome, we evaluated the effect of Advanced Trauma Life Support (ATLS program on medical interns' performance in simulated trauma patient management. Methods: A descriptive and analytical study before and after the training was conducted on 24 randomly se-lected undergraduate medical interns from Imam Reza Hos-pital in Mashhad, Iran. On the first day, we assessed in-terns' clinical knowledge and their practical skill performance in confronting simulated trauma patients. After 2 days of ATLS training, we performed the same study and evaluated their score again on the fourth day. The two findings, pre-and post- ATLS periods, were compared through SPSS ver-sion 15.0 software. P values less than 0.05 were considered statistically significant. Results: Our findings showed that interns’ ability in all the three tasks improved after the training course. On the fourth day after training, there was a statistically significant increase in interns' clinical knowledge of ATLS procedures, the sequence of procedures and skill performance in trauma situations (P<0.001, P=0.016 and P=0.01 respectively. Conclusion: ATLS course has an important role in increasing clinical knowledge and practical skill performance of trauma care in medical interns. Key words: Advanced Trauma Life Support Care; Knowledge; Inservice training; Wounds and injuries

  20. From Classical to Quantum and Back: A Hamiltonian Scheme for Adaptive Multiresolution Classical/Path-Integral Simulations.

    Science.gov (United States)

    Kreis, Karsten; Tuckerman, Mark E; Donadio, Davide; Kremer, Kurt; Potestio, Raffaello

    2016-07-12

    Quantum delocalization of atomic nuclei affects the physical properties of many hydrogen-rich liquids and biological systems even at room temperature. In computer simulations, quantum nuclei can be modeled via the path-integral formulation of quantum statistical mechanics, which implies a substantial increase in computational overhead. By restricting the quantum description to a small spatial region, this cost can be significantly reduced. Herein, we derive a bottom-up, rigorous, Hamiltonian-based scheme that allows molecules to change from quantum to classical and vice versa on the fly as they diffuse through the system, both reducing overhead and making quantum grand-canonical simulations possible. The method is validated via simulations of low-temperature parahydrogen. Our adaptive resolution approach paves the way to efficient quantum simulations of biomolecules, membranes, and interfaces. PMID:27214610

  1. Proactive monitoring and adaptive management of social carrying capacity in Arches National Park: an application of computer simulation modeling.

    Science.gov (United States)

    Lawson, Steven R; Manning, Robert E; Valliere, William A; Wang, Benjamin

    2003-07-01

    Public visits to parks and protected areas continue to increase and may threaten the integrity of natural and cultural resources and the quality of the visitor experience. Scientists and managers have adopted the concept of carrying capacity to address the impacts of visitor use. In the context of outdoor recreation, the social component of carrying capacity refers to the level of visitor use that can be accommodated in parks and protected areas without diminishing the quality of the visitor experience to an unacceptable degree. This study expands and illustrates the use of computer simulation modeling as a tool for proactive monitoring and adaptive management of social carrying capacity at Arches National Park. A travel simulation model of daily visitor use throughout the Park's road and trail network and at selected attraction sites was developed, and simulations were conducted to estimate a daily social carrying capacity for Delicate Arch, an attraction site in Arches National Park, and for the Park as a whole. Further, a series of simulations were conducted to estimate the effect of a mandatory shuttle bus system on daily social carrying capacity of Delicate Arch to illustrate how computer simulation modeling can be used as a tool to facilitate adaptive management of social carrying capacity.

  2. Single Wake Meandering, Advection and Expansion - An analysis using an adapted Pulsed Lidar and CFD LES-ACL simulations

    DEFF Research Database (Denmark)

    Machefaux, Ewan; Larsen, Gunner Chr.; Troldborg, Niels;

    2013-01-01

    In this paper, single wake characteristics have been studied both experimentally and numerically. Firstly, the wake is studied experimentally using full-scale measurements from an adapted focused pulsed lidar system, which potentially gives more insight into the wake dynamics as compared to class...... using the EllipSys3D flow solver using Large Eddy Simulation (LES) and Actuator Line Technique (ACL) to model the rotor. Discrepancies due to the uncertainties on the wake advection velocity are observed and discussed....

  3. Single Wake Meandering, Advection and Expansion - An analysis using an adapted Pulsed Lidar and CFD LES-ACL simulations

    DEFF Research Database (Denmark)

    In this paper, single wake characteristics have been studied both experimentally and numerically. Firstly, the wake is studied experimentally using full-scale measurements from an adapted focused pulsed lidar system, which potentially gives more insight into the wake dynamics as compared to class...... using the EllipSys3D flow solver using Large Eddy Simulation (LES) and Actuator Line Technique (ACL) to model the rotor. Discrepancies due to the uncertainties on the wake advection velocity are observed and discussed....

  4. Career Adapt-Abilities Scale--Italian Form: Psychometric Properties and Relationships to Breadth of Interests, Quality of Life, and Perceived Barriers

    Science.gov (United States)

    Soresi, Salvatore; Nota, Laura; Ferrari, Lea

    2012-01-01

    The Career Adapt-Abilities Scale (CAAS)-Italian Form consists of four 6-item scales, which measure concern, control, curiosity, and confidence as psychosocial resources for managing occupational transitions, developmental tasks, and work traumas. The 24-item CAAS-Italian Form is identical to the International Form 2.0. The factor structure was…

  5. The Life History of Flabellula baltica Smirnov (Gymnamoebae, Rhizopoda): Adaptations to a Spatially and Temporally Heterogeneous Environment

    DEFF Research Database (Denmark)

    Fenchel, Tom

    2010-01-01

    The polymorphic life history of the marine naked amoeba Flabellula baltica was studied. It can be interpreted in terms of adaptations to an environment that is patchy in time and space and it represents trade-off between longevity during starvation and the ability to initiate multiplication soon...

  6. [Complex estimation of the state of health, quality of life, level of psychological adaptation and rates of senescence of war veterans, suffering from arterial hypertension].

    Science.gov (United States)

    Zakharova, N O; Iakovlev, O G; Treneva, E V

    2014-01-01

    The article presents some aspects of the health status of the veterans of the Samara region. Intercommunication is marked between the level of social adaptation, quality of life and rate aging combatants. The study shows the effect of chronic posttraumatic stress disorder on the occurrence of psychosomatic pathology and development of senescence combat veterans suffering from arterial hypertension. PMID:25051769

  7. Validity and reliability of the Dutch adaptation of the Psoriatic Arthritis Quality of Life (PsAQoL Questionnaire.

    Directory of Open Access Journals (Sweden)

    Freke Wink

    Full Text Available OBJECTIVE: The Psoriatic Arthritis Quality of Life (PsAQoL questionnaire is a disease- specific instrument developed to measure quality of life (QoL in patients with psoriatic arthritis (PsA. The aim of this study was to translate the measure into Dutch and to determine its psychometric properties. METHOD: Translation of the original English PsAQoL into Dutch was performed by bilingual and lay panel. Ten field-test interviews with PsA patients were performed to assess face and content validity. In total, 211 PsA patients were included in a test-retest postal survey to investigate the reliability and construct validity of the Dutch adaptation of the PsAQoL. The PsAQoL, Health Assessment Questionnaire (HAQ and Skindex-17 were administered on two different occasions approximately two weeks apart. RESULTS: The Dutch version of the PsAQoL was found to be relevant, understandable and easy to complete in only a few minutes. It correlated as expected with the HAQ (Spearman's ρ = 0.72 and the 2 subscales of the Skindex-17 (ρ = 0.40 for the psychosocial and ρ = 0.46 for the symptom scale. Furthermore, the measure had good internal consistency (Cronbach's α = 0.92 and test-retest reliability (ρ = 0.89. The PsAQoL was able to define groups of patients based on self-reported general health status, self-reported severity of PsA and flare of arthritis. Duration of PsA did not influence PsAQoL scores. CONCLUSIONS: The Dutch version of the PsAQoL is a valid and reliable questionnaire suitable for use in clinical or research settings to asses PsA-specific QoL.

  8. A novel medical image data-based multi-physics simulation platform for computational life sciences.

    Science.gov (United States)

    Neufeld, Esra; Szczerba, Dominik; Chavannes, Nicolas; Kuster, Niels

    2013-04-01

    Simulating and modelling complex biological systems in computational life sciences requires specialized software tools that can perform medical image data-based modelling, jointly visualize the data and computational results, and handle large, complex, realistic and often noisy anatomical models. The required novel solvers must provide the power to model the physics, biology and physiology of living tissue within the full complexity of the human anatomy (e.g. neuronal activity, perfusion and ultrasound propagation). A multi-physics simulation platform satisfying these requirements has been developed for applications including device development and optimization, safety assessment, basic research, and treatment planning. This simulation platform consists of detailed, parametrized anatomical models, a segmentation and meshing tool, a wide range of solvers and optimizers, a framework for the rapid development of specialized and parallelized finite element method solvers, a visualization toolkit-based visualization engine, a Python scripting interface for customized applications, a coupling framework, and more. Core components are cross-platform compatible and use open formats. Several examples of applications are presented: hyperthermia cancer treatment planning, tumour growth modelling, evaluating the magneto-haemodynamic effect as a biomarker and physics-based morphing of anatomical models. PMID:24427518

  9. `Grandeur in this view of life': N-body simulation models of the Galactic habitable zone

    Science.gov (United States)

    Vukotić, B.; Steinhauser, D.; Martinez-Aviles, G.; Ćirković, M. M.; Micic, M.; Schindler, S.

    2016-07-01

    We present an isolated Milky-Way-like simulation in the GADGET2 N-body smoothed particle hydrodynamics (SPH) code. The Galactic disc star formation rate (SFR) surface densities and a stellar mass indicative of the Solar neighbourhood are used as thresholds to model the distribution of stellar mass in life-friendly environments. SFR and stellar component density are calculated by averaging the GADGET2 particle properties on a 2D grid mapped on the Galactic plane. The peak values for possibly habitable stellar mass surface density move from 10 to 15 kpc cylindrical galactocentric distance in a 10-Gyr simulated time span. At 10 Gyr, the simulation results imply the following. Stellar particles that have spent almost all of their lifetime in habitable-friendly conditions typically reside at ˜16 kpc from the Galactic Centre and are ˜3 Gyr old. Stellar particles that have spent ≥90 per cent of their 4-5 Gyr long lifetime in habitable-friendly conditions are also predominantly found in the outskirts of the Galactic disc. Fewer than 1 per cent of these particles can be found at a typical Solar system galactocentric distance of 8-10 kpc. Our results imply that the evolution of an isolated spiral galaxy is likely to result in galactic civilizations emerging at the outskirts of the galactic disc around stellar hosts younger than the Sun.

  10. Adaptive Mesh Refinement and High Order Geometrical Moment Method for the Simulation of Polydisperse Evaporating Sprays

    Directory of Open Access Journals (Sweden)

    Essadki Mohamed

    2016-09-01

    Full Text Available Predictive simulation of liquid fuel injection in automotive engines has become a major challenge for science and applications. The key issue in order to properly predict various combustion regimes and pollutant formation is to accurately describe the interaction between the carrier gaseous phase and the polydisperse evaporating spray produced through atomization. For this purpose, we rely on the EMSM (Eulerian Multi-Size Moment Eulerian polydisperse model. It is based on a high order moment method in size, with a maximization of entropy technique in order to provide a smooth reconstruction of the distribution, derived from a Williams-Boltzmann mesoscopic model under the monokinetic assumption [O. Emre (2014 PhD Thesis, École Centrale Paris; O. Emre, R.O. Fox, M. Massot, S. Chaisemartin, S. Jay, F. Laurent (2014 Flow, Turbulence and Combustion 93, 689-722; O. Emre, D. Kah, S. Jay, Q.-H. Tran, A. Velghe, S. de Chaisemartin, F. Laurent, M. Massot (2015 Atomization Sprays 25, 189-254; D. Kah, F. Laurent, M. Massot, S. Jay (2012 J. Comput. Phys. 231, 394-422; D. Kah, O. Emre, Q.-H. Tran, S. de Chaisemartin, S. Jay, F. Laurent, M. Massot (2015 Int. J. Multiphase Flows 71, 38-65; A. Vié, F. Laurent, M. Massot (2013 J. Comp. Phys. 237, 277-310]. The present contribution relies on a major extension of this model [M. Essadki, S. de Chaisemartin, F. Laurent, A. Larat, M. Massot (2016 Submitted to SIAM J. Appl. Math.], with the aim of building a unified approach and coupling with a separated phases model describing the dynamics and atomization of the interface near the injector. The novelty is to be found in terms of modeling, numerical schemes and implementation. A new high order moment approach is introduced using fractional moments in surface, which can be related to geometrical quantities of the gas-liquid interface. We also provide a novel algorithm for an accurate resolution of the evaporation. Adaptive mesh refinement properly scaling on massively

  11. Itch Severity and Quality of Life in Patients with Pruritus: Preliminary Validity of a Danish Adaptation of the Itch Severity Scale

    DEFF Research Database (Denmark)

    Zachariae, Robert; Lei, Ulrikke; Hædersdal, Merete;

    2012-01-01

    The aim of this study was to examine the validity of a Danish adaptation of the Itch Severity Scale (ISS) by exploring the associations between pruritus severity, psychological symptoms, and quality of life in a consecutively recruited sample of 20 patients with atopic dermatitis, 20 with psorias...... severity, sleep quality, depressive symptoms, anxiety, non-specific somatic symptoms, and pruritus-related quality of life impairment. Patients with urticaria reported significantly (p¿......The aim of this study was to examine the validity of a Danish adaptation of the Itch Severity Scale (ISS) by exploring the associations between pruritus severity, psychological symptoms, and quality of life in a consecutively recruited sample of 20 patients with atopic dermatitis, 20 with psoriasis...

  12. Brazilian cross-cultural translation and adaptation of the "Questionnaire of Life Quality Specific for Myasthenia Gravis - 15 items"

    Directory of Open Access Journals (Sweden)

    Aline Mansueto Mourao

    2013-12-01

    Full Text Available Objective To translate and to perform the cross-cultural adaptation of the “Questionnaire of Life Quality Specific for Myasthenia Gravis - 15 items” (MG-QOL15. Method The original English version of the questionnaire was translated into Portuguese. This version was revised and translated back into English. Later, both English versions were compared and the divergences were corrected in the Portuguese text. At a second stage, ten patients with MG followed at the Neuromuscular Diseases Clinic from the University Hospital, Universidade Federal de Minas Gerais answered the questionnaire. The authors analyzed the difficulties and misunderstandings in the application of the questionnaire. Results The questions 8, 13 and 15 were considered difficult to understand and were modified in the final Portuguese version. Most patients (70% had a total score above 25, and the statements 3, 8 and 9 showed the highest scores. Conclusion The Brazilian version of the questionnaire MG-QOL15 seems to be a promising tool for the assessment of Brazilian patients with MG.

  13. An adaptive multi-spline refinement algorithm in simulation based sailboat trajectory optimization using onboard multi-core computer systems

    Directory of Open Access Journals (Sweden)

    Dębski Roman

    2016-06-01

    Full Text Available A new dynamic programming based parallel algorithm adapted to on-board heterogeneous computers for simulation based trajectory optimization is studied in the context of “high-performance sailing”. The algorithm uses a new discrete space of continuously differentiable functions called the multi-splines as its search space representation. A basic version of the algorithm is presented in detail (pseudo-code, time and space complexity, search space auto-adaptation properties. Possible extensions of the basic algorithm are also described. The presented experimental results show that contemporary heterogeneous on-board computers can be effectively used for solving simulation based trajectory optimization problems. These computers can be considered micro high performance computing (HPC platforms-they offer high performance while remaining energy and cost efficient. The simulation based approach can potentially give highly accurate results since the mathematical model that the simulator is built upon may be as complex as required. The approach described is applicable to many trajectory optimization problems due to its black-box represented performance measure and use of OpenCL.

  14. A self-organizing Lagrangian particle method for adaptive-resolution advection-diffusion simulations

    Science.gov (United States)

    Reboux, Sylvain; Schrader, Birte; Sbalzarini, Ivo F.

    2012-05-01

    We present a novel adaptive-resolution particle method for continuous parabolic problems. In this method, particles self-organize in order to adapt to local resolution requirements. This is achieved by pseudo forces that are designed so as to guarantee that the solution is always well sampled and that no holes or clusters develop in the particle distribution. The particle sizes are locally adapted to the length scale of the solution. Differential operators are consistently evaluated on the evolving set of irregularly distributed particles of varying sizes using discretization-corrected operators. The method does not rely on any global transforms or mapping functions. After presenting the method and its error analysis, we demonstrate its capabilities and limitations on a set of two- and three-dimensional benchmark problems. These include advection-diffusion, the Burgers equation, the Buckley-Leverett five-spot problem, and curvature-driven level-set surface refinement.

  15. Particle Swarm Social Adaptive Model for Multi-Agent Based Insurgency Warfare Simulation

    Energy Technology Data Exchange (ETDEWEB)

    Cui, Xiaohui [ORNL; Potok, Thomas E [ORNL

    2009-12-01

    To better understand insurgent activities and asymmetric warfare, a social adaptive model for modeling multiple insurgent groups attacking multiple military and civilian targets is proposed and investigated. This report presents a pilot study using the particle swarm modeling, a widely used non-linear optimal tool to model the emergence of insurgency campaign. The objective of this research is to apply the particle swarm metaphor as a model of insurgent social adaptation for the dynamically changing environment and to provide insight and understanding of insurgency warfare. Our results show that unified leadership, strategic planning, and effective communication between insurgent groups are not the necessary requirements for insurgents to efficiently attain their objective.

  16. Effect of Advanced Trauma Life Support program on medical interns' performance in simulated trauma patient management

    Institute of Scientific and Technical Information of China (English)

    Koorosh Ahmadi; Mohammad Sedaghat; Mahdi Safdarian; Amir Masoud Hashemian; Zahra Nezamdoust; Mohammad Vaseie; Vafa Rahimi-Movaghar

    2013-01-01

    Since appropriate and timetable methods in trauma care have an important impact on patients' outcome,we evaluated the effect of Advanced Trauma Life Support (ATLS) program on medical interns'performance in simulated trauma patient management.Methods:A descriptive and analytical study before and after the training was conducted on 24 randomly selected undergraduate medical interns from Imam Reza Hospital in Mashhad,Iran.On the first day,we assessed interns' clinical knowledge and their practical skill performance in confronting simulated trauma patients.After 2 days of ATLS training,we performed the same study and evaluated their score again on the fourth day.The two findings,preand post-ATLS periods,were compared through SPSS version 15.0 software.P values less than 0.05 were considered statistically significant.Results:Our findings showed that interns' ability in all the three tasks improved after the training course.On the fourth day after training,there was a statistically significant increase in interns' clinical knowledge of ATLS procedures,the sequence of procedures and skill performance in trauma situations (P<0.001,P=0.016 and P=0.01 respectively).Conclusion:ATLS course has an important role in increasing clinical knowledge and practical skill performance of trauma care in medical interns.

  17. Productive confusions: learning from simulations of pandemic virus outbreaks in Second Life

    Science.gov (United States)

    Cárdenas, Micha; Greci, Laura S.; Hurst, Samantha; Garman, Karen; Hoffman, Helene; Huang, Ricky; Gates, Michael; Kho, Kristen; Mehrmand, Elle; Porteous, Todd; Calvitti, Alan; Higginbotham, Erin; Agha, Zia

    2011-03-01

    Users of immersive virtual reality environments have reported a wide variety of side and after effects including the confusion of characteristics of the real and virtual worlds. Perhaps this side effect of confusing the virtual and real can be turned around to explore the possibilities for immersion with minimal technological support in virtual world group training simulations. This paper will describe observations from my time working as an artist/researcher with the UCSD School of Medicine (SoM) and Veterans Administration San Diego Healthcare System (VASDHS) to develop trainings for nurses, doctors and Hospital Incident Command staff that simulate pandemic virus outbreaks. By examining moments of slippage between realities, both into and out of the virtual environment, moments of the confusion of boundaries between real and virtual, we can better understand methods for creating immersion. I will use the mixing of realities as a transversal line of inquiry, borrowing from virtual reality studies, game studies, and anthropological studies to better understand the mechanisms of immersion in virtual worlds. Focusing on drills conducted in Second Life, I will examine moments of training to learn the software interface, moments within the drill and interviews after the drill.

  18. A Hardware-Accelerated Fast Adaptive Vortex-Based Flow Simulation Software Project

    Data.gov (United States)

    National Aeronautics and Space Administration — Applied Scientific Research has recently developed a Lagrangian vortex-boundary element method for the grid-free simulation of unsteady incompressible...

  19. Evaluating adaptation options for urban flooding based on new high-end emission scenario regional climate model simulations

    DEFF Research Database (Denmark)

    Arnbjerg-Nielsen, Karsten; Leonardsen, L.; Madsen, Henrik

    2015-01-01

    Climate change adaptation studies on urban flooding are often based on a model chain approach from climate forcing scenarios to analysis of adaptation measures. Previous analyses of climate change impacts in Copenhagen, Denmark, were supplemented by 2 high-end scenario simulations. These include...... not seem to change substantially compared to currently applied projections. The flood risk (in terms of expected annual damage, EAD) from sea surge is likely to increase by more than 2 orders of magnitude in 2100 compared to the present cost. The risk from pluvial flooding in 2000 is likely to increase...... to pluvial flooding that makes the urban areas more robust and reduces the risk of flooding under the current climate to a very low level. The reduction in flood risk for the A1B scenario is substantial (corresponding to 0.2-0.3 times the current EAD in 2100), and even in the high-end scenarios, the risk...

  20. Numerical simulation of 3D flow past a real-life marine hydrokinetic turbine

    Science.gov (United States)

    Kang, Seokkoo; Borazjani, Iman; Colby, Jonathan A.; Sotiropoulos, Fotis

    2012-04-01

    We simulate three-dimensional, turbulent flow past an axial-flow marine hydrokinetic (MHK) turbine mounted on the bed of a rectangular open channel by adapting a computational framework developed for carrying out high-resolution large-eddy simulation (LES) in arbitrarily complex domains involving moving or stationary boundaries. The complex turbine geometry, including the rotor and all stationary components, is handled by employing the curvilinear immersed boundary (CURVIB) method [1,2]. Velocity boundary conditions near all solid surfaces are reconstructed using a wall model based on solving the simplified boundary layer equations [2]. To demonstrate the capabilities of the model we apply it to simulate the flow past a Gen4 axial flow MHK turbine developed by Verdant Power for the Roosevelt Island Tidal Energy (RITE) project in the East River in New York City, USA. We carry out systematic grid refinement studies, using grids with up to 185 million nodes, for only the turbine rotor placed in an infinite free stream to show that the computed torque converges to a grid insensitive value, which is in good agreement with field measurements. We also carry out LES for the complete turbine configuration, including the pylon, nacelle and rotor, mounted on the bed of a straight rectangular open channel. The computed results illustrate the complexity of the flow and show that the power output of the complete turbine is primarily dependent on the rotor geometry and tip speed ratio, and is not affected by the stationary components of the turbine and the presence of the channel bed. The complete turbine simulation also reveals that the downstream wake of the turbine consists of three main regions: (1) the outer layer with the spiral blade tip vortices rotating in the same direction as the blades; (2) the counter-rotating inner layer surrounded by the spiral tip vortices; and (3) the core layer co-rotating with respect to the tip vortices. This study is the first to report the

  1. A new look at ichthyosaur long bone microanatomy and histology: implications for their adaptation to an aquatic life.

    Directory of Open Access Journals (Sweden)

    Alexandra Houssaye

    Full Text Available BACKGROUND: Ichthyosaurs are Mesozoic reptiles considered as active swimmers highly adapted to a fully open-marine life. They display a wide range of morphologies illustrating diverse ecological grades. Data concerning their bone microanatomical and histological features are rather limited and suggest that ichthyosaurs display a spongious, "osteoporotic-like" bone inner structure, like extant cetaceans. However, some taxa exhibit peculiar features, suggesting that the analysis of the microanatomical and histological characteristics of various ichthyosaur long bones should match the anatomical diversity and provide information about their diverse locomotor abilities and physiology. METHODOLOGY/PRINCIPAL FINDINGS: The material analyzed for this study essentially consists of mid-diaphyseal transverse sections from stylopod bones of various ichthyosaurs and of a few microtomographic (both conventional and synchrotron data. The present contribution discusses the histological and microanatomical variation observed within ichthyosaurs and the peculiarities of some taxa (Mixosaurus, Pessopteryx. Four microanatomical types are described. If Mixosaurus sections differ from those of the other taxa analyzed, the other microanatomical types, characterized by the relative proportion of compact and loose spongiosa of periosteal and endochondral origin respectively, seem to rather especially illustrate variation along the diaphysis in taxa with similar microanatomical features. Our analysis also reveals that primary bone in all the ichthyosaur taxa sampled (to the possible exception of Mixosaurus is spongy in origin, that cyclical growth is a common pattern among ichthyosaurs, and confirms the previous assumptions of high growth rates in ichthyosaurs. CONCLUSIONS/SIGNIFICANCE: The occurrence of two types of remodelling patterns along the diaphysis, characterized by bone mass decrease and increase respectively is described for the first time. It raises questions

  2. Adaptive learning in agents behaviour: A framework for electricity markets simulation

    DEFF Research Database (Denmark)

    Pinto, Tiago; Vale, Zita; Sousa, Tiago M.;

    2014-01-01

    decision support to MASCEM's negotiating agents so that they can properly achieve their goals. ALBidS uses artificial intelligence methodologies and data analysis algorithms to provide effective adaptive learning capabilities to such negotiating entities. The main contribution is provided by a methodology...... of the efficiency/effectiveness balance of the system, and a mechanism for competitor players' profiles definition....

  3. A quadtree adaptive method for simulating fluid flows with moving interfaces

    International Nuclear Information System (INIS)

    In this paper, a computational method for solving fluid flow problems with moving interfaces is presented. Herein, adaptive quadtree grids are used coupled with the CICSAM [O. Ubbink, Numerical prediction of two fluid systems with sharp interfaces, PhD Thesis, Imperial College of Science, Technology and Medicine, London, 1997] free surface capturing volume of fluid (VoF) method and PLIC reconstruction to interpolate the volume fraction field during refinement and derefinement processes. The combination of high resolution adaptive hierarchical remeshing and CICSAM interface advection is shown to overcome the problems of interface smearing and high CPU intensivity inherent in most VoF schemes. The result is a combination of free surface tracking and free surface capturing in that the interface is effectively tracked by the adapting refinements in the quadtree grid. In this way, a sharp interface is achieved and the advantages of both free surface tracking and capturing are combined. The new method is applied to interface advection examples in translating, rotating and shearing flow fields, and the benefits of using adapting quadtree grids demonstrated

  4. SIMCA T 1.0: A SAS Computer Program for Simulating Computer Adaptive Testing

    Science.gov (United States)

    Raiche, Gilles; Blais, Jean-Guy

    2006-01-01

    Monte Carlo methodologies are frequently applied to study the sampling distribution of the estimated proficiency level in adaptive testing. These methods eliminate real situational constraints. However, these Monte Carlo methodologies are not currently supported by the available software programs, and when these programs are available, their…

  5. Modeling and Simulation of An Adaptive Neuro-Fuzzy Inference System (ANFIS) for Mobile Learning

    Science.gov (United States)

    Al-Hmouz, A.; Shen, Jun; Al-Hmouz, R.; Yan, Jun

    2012-01-01

    With recent advances in mobile learning (m-learning), it is becoming possible for learning activities to occur everywhere. The learner model presented in our earlier work was partitioned into smaller elements in the form of learner profiles, which collectively represent the entire learning process. This paper presents an Adaptive Neuro-Fuzzy…

  6. Development and Simulation Testing of a Computerized Adaptive Version of the Philadelphia Naming Test

    Science.gov (United States)

    Hula, William D.; Kellough, Stacey; Fergadiotis, Gerasimos

    2015-01-01

    Purpose: The purpose of this study was to develop a computerized adaptive test (CAT) version of the Philadelphia Naming Test (PNT; Roach, Schwartz, Martin, Grewal, & Brecher, 1996), to reduce test length while maximizing measurement precision. This article is a direct extension of a companion article (Fergadiotis, Kellough, & Hula, 2015),…

  7. An Evolving Simulation/Gaming Process to Facilitate Adaptive Watershed Management in Northern Mountainous Thailand

    Science.gov (United States)

    Barnaud, Cecile; Promburom, Tanya; Trebuil, Guy; Bousquet, Francois

    2007-01-01

    The decentralization of natural resource management provides an opportunity for communities to increase their participation in related decision making. Research should propose adapted methodologies enabling the numerous stakeholders of these complex socioecological settings to define their problems and identify agreed-on solutions. This article…

  8. Adaptive Mixture of Student-t distributions as a Flexible Candidate Distribution for Efficient Simulation

    NARCIS (Netherlands)

    D. David (David); L.F. Hoogerheide (Lennart); H.K. van Dijk (Herman)

    2008-01-01

    textabstractThis paper presents the R package AdMit which provides functions to approximate and sample from a certain target distribution given only a kernel of the target density function. The core algorithm consists in the function AdMit which fits an adaptive mixture of Student-t distributions to

  9. Adapting SimpleTreat for simulating behaviour of chemical substances during industrial sewage treatment

    NARCIS (Netherlands)

    Struijs, J.; van de Meent, D.; Schowanek, D.; Buchholz, H.; Patoux, R.; Wolf, T.; Austin, T.; Tolls, J.; van Leeuwen, K.; Galay-Burgos, M.

    2016-01-01

    The multimedia model SimpleTreat, evaluates the distribution and elimination of chemicals by municipal sewage treatment plants (STP). It is applied in the framework of REACH (Registration, Evaluation, Authorization and Restriction of Chemicals). This article describes an adaptation of this model for

  10. High-Fidelity Space-Time Adaptive Multiphysics Simulations in Nuclear Engineering

    Energy Technology Data Exchange (ETDEWEB)

    Solin, Pavel [Univ. of Reno, NV (United States); Ragusa, Jean [Texas A & M Univ., College Station, TX (United States)

    2014-03-09

    We delivered a series of fundamentally new computational technologies that have the potential to significantly advance the state-of-the-art of computer simulations of transient multiphysics nuclear reactor processes. These methods were implemented in the form of a C++ library, and applied to a number of multiphysics coupled problems relevant to nuclear reactor simulations.

  11. Simulated annealing method for electronic circuits design: adaptation and comparison with other optimization methods; La methode du recuit simule pour la conception des circuits electroniques: adaptation et comparaison avec d`autres methodes d`optimisation

    Energy Technology Data Exchange (ETDEWEB)

    Berthiau, G.

    1995-10-01

    The circuit design problem consists in determining acceptable parameter values (resistors, capacitors, transistors geometries ...) which allow the circuit to meet various user given operational criteria (DC consumption, AC bandwidth, transient times ...). This task is equivalent to a multidimensional and/or multi objective optimization problem: n-variables functions have to be minimized in an hyper-rectangular domain ; equality constraints can be eventually specified. A similar problem consists in fitting component models. In this way, the optimization variables are the model parameters and one aims at minimizing a cost function built on the error between the model response and the data measured on the component. The chosen optimization method for this kind of problem is the simulated annealing method. This method, provided by the combinatorial optimization domain, has been adapted and compared with other global optimization methods for the continuous variables problems. An efficient strategy of variables discretization and a set of complementary stopping criteria have been proposed. The different parameters of the method have been adjusted with analytical functions of which minima are known, classically used in the literature. Our simulated annealing algorithm has been coupled with an open electrical simulator SPICE-PAC of which the modular structure allows the chaining of simulations required by the circuit optimization process. We proposed, for high-dimensional problems, a partitioning technique which ensures proportionality between CPU-time and variables number. To compare our method with others, we have adapted three other methods coming from combinatorial optimization domain - the threshold method, a genetic algorithm and the Tabu search method - The tests have been performed on the same set of test functions and the results allow a first comparison between these methods applied to continuous optimization variables. (Abstract Truncated)

  12. Neural adaptation and perceptual learning using a portable real-time cochlear implant simulator in natural environments.

    Science.gov (United States)

    Smalt, Christopher J; Talavage, Thomas M; Pisoni, David B; Svirsky, Mario A

    2011-01-01

    A portable real-time speech processor that implements an acoustic simulation model of a cochlear implant (CI) has been developed on the Apple iPhone / iPod Touch to permit testing and experimentation under extended exposure in real-world environments. This simulator allows for both a variable number of noise band channels and electrode insertion depth. Utilizing this portable CI simulator, we tested perceptual learning in normal hearing listeners by measuring word and sentence comprehension behaviorally before and after 2 weeks of exposure. To evaluate changes in neural activation related to adaptation to transformed speech, fMRI was also conducted. Differences in brain activation after training occurred in the inferior frontal gyrus and areas related to language processing. A 15-20% improvement in word and sentence comprehension of cochlear implant simulated speech was also observed. These results demonstrate the effectiveness of a portable CI simulator as a research tool and provide new information about the physiological changes that accompany perceptual learning of degraded auditory input. PMID:22254517

  13. Glucose homeostasis and metabolic adaptation in the pregnant and lactating sheep are affected by the level of nutrition previously provided during her late fetal life

    DEFF Research Database (Denmark)

    Husted, Sanne Munch; Nielsen, Mette Benedicte Olaf; Blache, D.;

    2008-01-01

    This study investigated whether undernutrition (UN) during late fetal life can programme the subsequent adult life adaptation of glucose homeostasis and metabolism during pregnancy and lactation. Twenty-four primiparous experimental ewes were used. Twelve had been exposed to a prenatal NORM level...... of nutrition (maternal diet approximately 15 MJME/d) and 12 to a LOW level of nutrition (maternal diet approximately 7 MJME/d) during the last 6 weeks pre-partum. The experimental ewes were subjected to two intravenous glucose tolerance tests (IGTT) in late gestation (one prior to (G-IGTT) and one by the end...

  14. A low numerical dissipation patch-based adaptive mesh refinement method for large-eddy simulation of compressible flows

    Science.gov (United States)

    Pantano, C.; Deiterding, R.; Hill, D. J.; Pullin, D. I.

    2007-01-01

    We present a methodology for the large-eddy simulation of compressible flows with a low-numerical dissipation scheme and structured adaptive mesh refinement (SAMR). A description of a conservative, flux-based hybrid numerical method that uses both centered finite-difference and a weighted essentially non-oscillatory (WENO) scheme is given, encompassing the cases of scheme alternation and internal mesh interfaces resulting from SAMR. In this method, the centered scheme is used in turbulent flow regions while WENO is employed to capture shocks. One-, two- and three-dimensional numerical experiments and example simulations are presented including homogeneous shock-free turbulence, a turbulent jet and the strongly shock-driven mixing of a Richtmyer-Meshkov instability.

  15. Path Integral Molecular Dynamics within the Grand Canonical-like Adaptive Resolution Technique: Quantum-Classical Simulation of Liquid Water

    CERN Document Server

    Agarwal, Animesh

    2015-01-01

    Quantum effects due to the spatial delocalization of light atoms are treated in molecular simulation via the path integral technique. Among several methods, Path Integral (PI) Molecular Dynamics (MD) is nowadays a powerful tool to investigate properties induced by spatial delocalization of atoms; however computationally this technique is very demanding. The abovementioned limitation implies the restriction of PIMD applications to relatively small systems and short time scales. One possible solution to overcome size and time limitation is to introduce PIMD algorithms into the Adaptive Resolution Simulation Scheme (AdResS). AdResS requires a relatively small region treated at path integral level and embeds it into a large molecular reservoir consisting of generic spherical coarse grained molecules. It was previously shown that the realization of the idea above, at a simple level, produced reasonable results for toy systems or simple/test systems like liquid parahydrogen. Encouraged by previous results, in this ...

  16. Applying computer adaptive testing to optimize online assessment of suicidal behavior: a simulation study.

    OpenAIRE

    Beurs, D.P. de; Vries, A.L.M. de; Groot, M.H. de; Keijser, J. de; Kerkhof, A.J.F.M.

    2014-01-01

    Background The Internet is used increasingly for both suicide research and prevention. To optimize online assessment of suicidal patients, there is a need for short, good-quality tools to assess elevated risk of future suicidal behavior. Computer adaptive testing (CAT) can be used to reduce response burden and improve accuracy, and make the available pencil-and-paper tools more appropriate for online administration. Objective The aim was to test whether an item response–based computer adaptiv...

  17. Adaptive smart simulator for characterization and MPPT construction of PV array

    Science.gov (United States)

    Ouada, Mehdi; Meridjet, Mohamed Salah; Dib, Djalel

    2016-07-01

    Partial shading conditions are among the most important problems in large photovoltaic array. Many works of literature are interested in modeling, control and optimization of photovoltaic conversion of solar energy under partial shading conditions, The aim of this study is to build a software simulator similar to hard simulator and to produce a shading pattern of the proposed photovoltaic array in order to use the delivered information to obtain an optimal configuration of the PV array and construct MPPT algorithm. Graphical user interfaces (Matlab GUI) are built using a developed script, this tool is easy to use, simple, and has a rapid of responsiveness, the simulator supports large array simulations that can be interfaced with MPPT and power electronic converters.

  18. iTETRIS: Adaptation of ITS Technologies for Large Scale Integrated Simulation

    OpenAIRE

    Vineet, Kumar; LAN, LIN; Daniel, Krajzewicz; Fatma, Hrizi; Oscar, Martinez; Javier, Gozalvez; Ramon, Bauza

    2010-01-01

    The European Union (EU) Framework Program 7 (FP7) funded project, iTETRIS [1] (An Integrated Wireless and Traffic Platform for Real-Time Road Traffic Management Solutions) targets to extend state of art in simulation of wireless vehicular cooperative systems for evaluation of road traffic management services and applications. In particular, iTETRIS addresses four important and distinct challenges: (a) road traffic and wireless integrated open-source simulation platform, (b) large scale trials...

  19. Report on three Genomes to Life Workshops: Data Infrastructure, Modeling and Simulation, and Protein Structure Prediction

    Energy Technology Data Exchange (ETDEWEB)

    Geist, GA

    2003-09-16

    On July 22, 23, 24, 2003, three one day workshops were held in Gaithersburg, Maryland. Each was attended by about 30 computational biologists, mathematicians, and computer scientists who were experts in the respective workshop areas The first workshop discussed the data infrastructure needs for the Genomes to Life (GTL) program with the objective to identify gaps in the present GTL data infrastructure and define the GTL data infrastructure required for the success of the proposed GTL facilities. The second workshop discussed the modeling and simulation needs for the next phase of the GTL program and defined how these relate to the experimental data generated by genomics, proteomics, and metabolomics. The third workshop identified emerging technical challenges in computational protein structure prediction for DOE missions and outlining specific goals for the next phase of GTL. The workshops were attended by representatives from both OBER and OASCR. The invited experts at each of the workshops made short presentations on what they perceived as the key needs in the GTL data infrastructure, modeling and simulation, and structure prediction respectively. Each presentation was followed by a lively discussion by all the workshop attendees. The following findings and recommendations were derived from the three workshops. A seamless integration of GTL data spanning the entire range of genomics, proteomics, and metabolomics will be extremely challenging but it has to be treated as the first-class component of the GTL program to assure GTL's chances for success. High-throughput GTL facilities and ultrascale computing will make it possible to address the ultimate goal of modern biology: to achieve a fundamental, comprehensive, and systematic understanding of life. But first the GTL community needs to address the problem of the massive quantities and increased complexity of biological data produced by experiments and computations. Genome-scale collection, analysis

  20. High Resolution Downscaling For Mesoamerica And The Caribbean Of CMIP5 Global Model Simulations: Identifying Vulnerability And Adaptation Needs

    Science.gov (United States)

    Oglesby, R. J.; Rowe, C. M.; Hays, C.

    2012-12-01

    High-resolution (4-12 km) dynamical downscaling simulations of future climate change between now and 2060 have been made for Mesoamerica and the Caribbean. We use the Weather Research and Forecasting (WRF) regional climate model to downscale results from the NCAR CCSM4 CMIP5 RCP8.5 global simulation. The entire region is covered at 12 km horizontal spatial resolution, with as much as possible (especially in mountainous regions) at 4 km. We compare a control period (2006-2010) with 50 years into the future (2056-2060). The motivation for making these computationally-demanding model simulations is to better define local and regional climate change effects so as to better identify and quantify impacts and associated vulnerabilities. This is an essential precursor to developing robust adaptation strategies. These simulations have been made in conjunction with our partners from the countries involved. As expected, all areas warm, with the warming in general largest in inland regions, and less towards coastal regions. Higher elevation regions also tend to warm somewhat more than lower elevation regions, a result that could not be reliably obtained, in detail, from coarse-scale global models. The precipitation signal is much more mixed, and demonstrates more clearly the need for high resolution. The effects of changes in the large-scale trade wind regime tend to be restricted to the immediate Atlantic coast, while the interior is less-well posed, with some indication of a northward shift in precipitation regime, due to changes both in the large-scale ITCZ, and the regional scale Caribbean and Gulf of Mexico low-level jets. Topographic resolution continues to play a key role. The new results are currently being used by both climate scientists and policy makers to evaluate vulnerabilities, and hence develop adaptation strategies for the affected countries.

  1. Valuation of Life in Old and Very Old Age: The Role of Sociodemographic, Social, and Health Resources for Positive Adaptation

    Science.gov (United States)

    Jopp, Daniela; Rott, Christoph; Oswald, Frank

    2008-01-01

    Purpose: Valuation of life (VOL) represents a construct capturing active attachment to life put forward by M. P. Lawton (e.g., 1999). As old and very old individuals may differ in terms of endorsement and with respect to what makes a life worth living, the present study investigated whether mean levels and the explanatory value of…

  2. Life-history trait plasticity and its relationships with plant adaptation and insect fitness: a case study on the aphid Sitobion avenae.

    Science.gov (United States)

    Dai, Peng; Shi, Xiaoqin; Liu, Deguang; Ge, Zhaohong; Wang, Da; Dai, Xinjia; Yi, Zhihao; Meng, Xiuxiang

    2016-01-01

    Phenotypic plasticity has recently been considered a powerful means of adaptation, but its relationships with corresponding life-history characters and plant specialization levels of insects have been controversial. To address the issues, Sitobion avenae clones from three plants in two areas were compared. Varying amounts of life-history trait plasticity were found among S. avenae clones on barley, oat and wheat. In most cases, developmental durations and their corresponding plasticities were found to be independent, and fecundities and their plasticities were correlated characters instead. The developmental time of first instar nymphs for oat and wheat clones, but not for barley clones, was found to be independent from its plasticity, showing environment-specific effects. All correlations between environments were found to be positive, which could contribute to low plasticity in S. avenae. Negative correlations between trait plasticities and fitness of test clones suggest that lower plasticity could have higher adaptive value. Correlations between plasticity and specialization indices were identified for all clones, suggesting that plasticity might evolve as a by-product of adaptation to certain environments. The divergence patterns of life-history plasticities in S. avenae, as well as the relationships among plasticity, specialization and fitness, could have significant implications for evolutionary ecology of this aphid. PMID:27426961

  3. Life-history trait plasticity and its relationships with plant adaptation and insect fitness: a case study on the aphid Sitobion avenae

    Science.gov (United States)

    Dai, Peng; Shi, Xiaoqin; Liu, Deguang; Ge, Zhaohong; Wang, Da; Dai, Xinjia; Yi, Zhihao; Meng, Xiuxiang

    2016-01-01

    Phenotypic plasticity has recently been considered a powerful means of adaptation, but its relationships with corresponding life-history characters and plant specialization levels of insects have been controversial. To address the issues, Sitobion avenae clones from three plants in two areas were compared. Varying amounts of life-history trait plasticity were found among S. avenae clones on barley, oat and wheat. In most cases, developmental durations and their corresponding plasticities were found to be independent, and fecundities and their plasticities were correlated characters instead. The developmental time of first instar nymphs for oat and wheat clones, but not for barley clones, was found to be independent from its plasticity, showing environment-specific effects. All correlations between environments were found to be positive, which could contribute to low plasticity in S. avenae. Negative correlations between trait plasticities and fitness of test clones suggest that lower plasticity could have higher adaptive value. Correlations between plasticity and specialization indices were identified for all clones, suggesting that plasticity might evolve as a by-product of adaptation to certain environments. The divergence patterns of life-history plasticities in S. avenae, as well as the relationships among plasticity, specialization and fitness, could have significant implications for evolutionary ecology of this aphid. PMID:27426961

  4. Simulation of Adaptive OFDM and its improved algorithm%自适应OFDM及其改进算法

    Institute of Scientific and Technical Information of China (English)

    郝丽娜; 宋金玲

    2011-01-01

    OFDM 技术是第四代移动通信的核心技术之一,是一种高效的数据传输方式,是一种特殊的多载波传输方案。本文介绍的改进后的自适应调制技术,自适应地根据星座图集所限定的比特数目来进行变步长调整,这样大大减少了计算量。并通过使用Matlab仿真出的结果与Campello算法仿真的结果进行比较,说明改进后的变步长的自适应OFDM算法的优越性。%OFDM technology is one of the core technologies of the fourth generation mobile communication, which is an efficient data transmission and is a special multi-carrier transmission scheme. The improved adaptive modulation technology adjusts the step of computing according to limited bits of constellation atlas, which reduce the computation greatly. Compared the result of the improved adaptive modulation technology with the result of Compello algorithm simulation, we find that the improved adaptive modulation OFDM technology has great advantages.

  5. Integrated Laboratory Demonstrations of Multi-Object Adaptive Optics on a Simulated 10-Meter Telescope at Visible Wavelengths

    CERN Document Server

    Ammons, S Mark; Laag, Edward A; Kupke, Renate; Gavel, Donald T; Bauman, Brian J; Max, Claire E

    2009-01-01

    One important frontier for astronomical adaptive optics (AO) involves methods such as Multi-Object AO and Multi-Conjugate AO that have the potential to give a significantly larger field of view than conventional AO techniques. A second key emphasis over the next decade will be to push astronomical AO to visible wavelengths. We have conducted the first laboratory simulations of wide-field, laser guide star adaptive optics at visible wavelengths on a 10-meter-class telescope. These experiments, utilizing the UCO/Lick Observatory's Multi-Object / Laser Tomography Adaptive Optics (MOAO/LTAO) testbed, demonstrate new techniques in wavefront sensing and control that are crucial to future on-sky MOAO systems. We (1) test and confirm the feasibility of highly accurate atmospheric tomography with laser guide stars, (2) demonstrate key innovations allowing open-loop operation of Shack-Hartmann wavefront sensors (with errors of ~30 nm) as will be needed for MOAO, and (3) build a complete error budget model describing sy...

  6. Hybrid Wind Speed Prediction Based on a Self-Adaptive ARIMAX Model with an Exogenous WRF Simulation

    Directory of Open Access Journals (Sweden)

    Erdong Zhao

    2015-12-01

    Full Text Available Wind speed forecasting is difficult not only because of the influence of atmospheric dynamics but also for the impossibility of providing an accurate prediction with traditional statistical forecasting models that work by discovering an inner relationship within historical records. This paper develops a self-adaptive (SA auto-regressive integrated moving average with exogenous variables (ARIMAX model that is optimized very-short-term by the chaotic particle swarm optimization (CPSO algorithm, known as the SA-ARIMA-CPSO approach, for wind speed prediction. The ARIMAX model chooses the wind speed result from the Weather Research and Forecasting (WRF simulation as an exogenous input variable. Further, an SA strategy is applied to the ARIMAX process. When new information is available, the model process can be updated adaptively with parameters optimized by the CPSO algorithm. The proposed SA-ARIMA-CPSO approach enables the forecasting process to update training information and model parameters intelligently and adaptively. As tested using the 15-min wind speed data collected from a wind farm in Northern China, the improved method has the best performance compared with several other models.

  7. Large eddy simulation of a high speed train geometry under cross-wind with an adaptive lattice Boltzmann method

    Science.gov (United States)

    Deiterding, Ralf; Fragner, Moritz M.

    2015-11-01

    Numerical investigations in order to determine the forces induced by side wind onto a train geometry are generally not sufficiently accurate to be used as a predictive tool for regulatory safety assessment. Especially for larger yaw angles, the turbulent cross-wind flow is characterized by highly instationary behavior, driven primarily by vortex shedding on the roof and underside geometric details, i.e., the bogie and wheel systems. While industry-typical Reynolds-averaged turbulence models are not well suited for this scenario, better results are obtained when large eddy simulation (LES) techniques are applied. Here, we employ a recently self-developed weakly compressible lattice Boltzmann method (LBM) with Smagorinsky LES model on hierarchically adaptive block-structured Cartesian meshes. Using a train front-car of 1:25 scale at yaw angle 30° and Re = 250 , 000 as main test case, we compare the LBM results with incompressible large eddy and detached eddy simulations on unstructured boundary-layer type meshes using the OpenFOAM package. It is found that time averaged force and moment predictions from our LBM code compare better to available wind tunnel data, while mesh adaptation and explicit nature of the LBM approach reduce the computational costs considerably.

  8. Parallel adaptive mesh refinement method based on WENO finite difference scheme for the simulation of multi-dimensional detonation

    Science.gov (United States)

    Wang, Cheng; Dong, XinZhuang; Shu, Chi-Wang

    2015-10-01

    For numerical simulation of detonation, computational cost using uniform meshes is large due to the vast separation in both time and space scales. Adaptive mesh refinement (AMR) is advantageous for problems with vastly different scales. This paper aims to propose an AMR method with high order accuracy for numerical investigation of multi-dimensional detonation. A well-designed AMR method based on finite difference weighted essentially non-oscillatory (WENO) scheme, named as AMR&WENO is proposed. A new cell-based data structure is used to organize the adaptive meshes. The new data structure makes it possible for cells to communicate with each other quickly and easily. In order to develop an AMR method with high order accuracy, high order prolongations in both space and time are utilized in the data prolongation procedure. Based on the message passing interface (MPI) platform, we have developed a workload balancing parallel AMR&WENO code using the Hilbert space-filling curve algorithm. Our numerical experiments with detonation simulations indicate that the AMR&WENO is accurate and has a high resolution. Moreover, we evaluate and compare the performance of the uniform mesh WENO scheme and the parallel AMR&WENO method. The comparison results provide us further insight into the high performance of the parallel AMR&WENO method.

  9. Path integral molecular dynamics within the grand canonical-like adaptive resolution technique: Simulation of liquid water

    Energy Technology Data Exchange (ETDEWEB)

    Agarwal, Animesh, E-mail: animesh@zedat.fu-berlin.de; Delle Site, Luigi, E-mail: dellesite@fu-berlin.de [Institute for Mathematics, Freie Universität Berlin, Berlin (Germany)

    2015-09-07

    Quantum effects due to the spatial delocalization of light atoms are treated in molecular simulation via the path integral technique. Among several methods, Path Integral (PI) Molecular Dynamics (MD) is nowadays a powerful tool to investigate properties induced by spatial delocalization of atoms; however, computationally this technique is very demanding. The above mentioned limitation implies the restriction of PIMD applications to relatively small systems and short time scales. One of the possible solutions to overcome size and time limitation is to introduce PIMD algorithms into the Adaptive Resolution Simulation Scheme (AdResS). AdResS requires a relatively small region treated at path integral level and embeds it into a large molecular reservoir consisting of generic spherical coarse grained molecules. It was previously shown that the realization of the idea above, at a simple level, produced reasonable results for toy systems or simple/test systems like liquid parahydrogen. Encouraged by previous results, in this paper, we show the simulation of liquid water at room conditions where AdResS, in its latest and more accurate Grand-Canonical-like version (GC-AdResS), is merged with two of the most relevant PIMD techniques available in the literature. The comparison of our results with those reported in the literature and/or with those obtained from full PIMD simulations shows a highly satisfactory agreement.

  10. Path integral molecular dynamics within the grand canonical-like adaptive resolution technique: Simulation of liquid water

    International Nuclear Information System (INIS)

    Quantum effects due to the spatial delocalization of light atoms are treated in molecular simulation via the path integral technique. Among several methods, Path Integral (PI) Molecular Dynamics (MD) is nowadays a powerful tool to investigate properties induced by spatial delocalization of atoms; however, computationally this technique is very demanding. The above mentioned limitation implies the restriction of PIMD applications to relatively small systems and short time scales. One of the possible solutions to overcome size and time limitation is to introduce PIMD algorithms into the Adaptive Resolution Simulation Scheme (AdResS). AdResS requires a relatively small region treated at path integral level and embeds it into a large molecular reservoir consisting of generic spherical coarse grained molecules. It was previously shown that the realization of the idea above, at a simple level, produced reasonable results for toy systems or simple/test systems like liquid parahydrogen. Encouraged by previous results, in this paper, we show the simulation of liquid water at room conditions where AdResS, in its latest and more accurate Grand-Canonical-like version (GC-AdResS), is merged with two of the most relevant PIMD techniques available in the literature. The comparison of our results with those reported in the literature and/or with those obtained from full PIMD simulations shows a highly satisfactory agreement

  11. An adaptive simulation model for analysis of nuclear material shipping operations

    International Nuclear Information System (INIS)

    Los Alamos has developed an advanced simulation environment designed specifically for nuclear materials operations. This process-level simulation package, the Process Modeling System (ProMoS), is based on high-fidelity material balance criteria and contains intrinsic mechanisms for waste and recycle flows, contaminant estimation and tracking, and material-constrained operations. Recent development efforts have focused on coupling complex personnel interactions, personnel exposure calculations, and stochastic process-personnel performance criteria to the material-balance simulation. This combination of capabilities allows for more realistic simulation of nuclear material handling operations where complex personnel interactions are required. They have used ProMoS to assess fissile material shipping performance characteristics at the Los Alamos National Laboratory plutonium facility (TA-55). Nuclear material shipping operations are ubiquitous in the DOE complex and require the largest suite of varied personnel interacting in a well-timed manner to accomplish the task. They have developed a baseline simulation of the present operations and have estimated the operational impacts and requirement of the pit production mission at TA-55 as a result of the SSM-PEIS. Potential bottlenecks have been explored and mechanisms for increasing operational efficiency are identified

  12. An adaptive simulation model for analysis of nuclear material shipping operations

    Energy Technology Data Exchange (ETDEWEB)

    Boerigter, S.T.; Sena, D.J.; Fasel, J.H.

    1998-12-31

    Los Alamos has developed an advanced simulation environment designed specifically for nuclear materials operations. This process-level simulation package, the Process Modeling System (ProMoS), is based on high-fidelity material balance criteria and contains intrinsic mechanisms for waste and recycle flows, contaminant estimation and tracking, and material-constrained operations. Recent development efforts have focused on coupling complex personnel interactions, personnel exposure calculations, and stochastic process-personnel performance criteria to the material-balance simulation. This combination of capabilities allows for more realistic simulation of nuclear material handling operations where complex personnel interactions are required. They have used ProMoS to assess fissile material shipping performance characteristics at the Los Alamos National Laboratory plutonium facility (TA-55). Nuclear material shipping operations are ubiquitous in the DOE complex and require the largest suite of varied personnel interacting in a well-timed manner to accomplish the task. They have developed a baseline simulation of the present operations and have estimated the operational impacts and requirement of the pit production mission at TA-55 as a result of the SSM-PEIS. Potential bottlenecks have been explored and mechanisms for increasing operational efficiency are identified.

  13. Walking in simulated Martian gravity: influence of the portable life support system's design on dynamic stability.

    Science.gov (United States)

    Scott-Pandorf, Melissa M; O'Connor, Daniel P; Layne, Charles S; Josić, Kresimir; Kurz, Max J

    2009-09-01

    With human exploration of the moon and Mars on the horizon, research considerations for space suit redesign have surfaced. The portable life support system (PLSS) used in conjunction with the space suit during the Apollo missions may have influenced the dynamic balance of the gait pattern. This investigation explored potential issues with the PLSS design that may arise during the Mars exploration. A better understanding of how the location of the PLSS load influences the dynamic stability of the gait pattern may provide insight, such that space missions may have more productive missions with a smaller risk of injury and damaging equipment while falling. We explored the influence the PLSS load position had on the dynamic stability of the walking pattern. While walking, participants wore a device built to simulate possible PLSS load configurations. Floquet and Lyapunov analysis techniques were used to quantify the dynamic stability of the gait pattern. The dynamic stability of the gait pattern was influenced by the position of load. PLSS loads that are placed high and forward on the torso resulted in less dynamically stable walking patterns than loads placed evenly and low on the torso. Furthermore, the kinematic results demonstrated that all joints of the lower extremity may be important for adjusting to different load placements and maintaining dynamic stability. Space scientists and engineers may want to consider PLSS designs that distribute loads evenly and low, and space suit designs that will not limit the sagittal plane range of motion at the lower extremity joints.

  14. Explicit Singly Diagonally Implicit Runge-Kutta Methods and Adaptive Stepsize Control for Reservoir Simulation

    DEFF Research Database (Denmark)

    Völcker, Carsten; Jørgensen, John Bagterp; Thomsen, Per Grove;

    2010-01-01

    The implicit Euler method, normally refered to as the fully implicit (FIM) method, and the implicit pressure explicit saturation (IMPES) method are the traditional choices for temporal discretization in reservoir simulation. The FIM method offers unconditionally stability in the sense of discrete....... Current reservoir simulators apply timestepping algorithms that are based on safeguarded heuristics, and can neither guarantee convergence in the underlying equation solver, nor provide estimates of the relations between convergence, integration error and stepsizes. We establish predictive stepsize...... control applied to high order methods for temporal discretization in reservoir simulation. The family of Runge-Kutta methods is presented and in particular the explicit singly diagonally implicit Runge-Kutta (ESDIRK) method with an embedded error estimate is described. A predictive stepsize adjustment...

  15. An adaptive finite element method for simulating surface tension with the gradient theory of fluid interfaces

    KAUST Repository

    Kou, Jisheng

    2014-01-01

    The gradient theory for the surface tension of simple fluids and mixtures is rigorously analyzed based on mathematical theory. The finite element approximation of surface tension is developed and analyzed, and moreover, an adaptive finite element method based on a physical-based estimator is proposed and it can be coupled efficiently with Newton\\'s method as well. The numerical tests are carried out both to verify the proposed theory and to demonstrate the efficiency of the proposed method. © 2013 Elsevier B.V. All rights reserved.

  16. Solution adaptive triangular meshes with application to the simulation of plasma equilibrium

    International Nuclear Information System (INIS)

    A new discrete Laplace operator is constructed on a local mesh molecule, second order accurate on symmetric cell regions, based on local Taylor series expansions. This discrete Laplacian is then compared to the one commonly used in the literature. A truncation error analysis of gradient and Laplace operators calculated at triangle centroids reveals that the maximum bounds of their truncation errors are minimized on equilateral triangles, for a fixed triangle perimeter. A new adaptive strategy on arbitrary triangular grids is developed in which a uniform grid is defined with respect to the solution surface, as opposed to the x,y plane. Departures from mesh uniformity arises from a spacially dependent mean-curvature of the solution surface. The power of this new adaptive technique is applied to the problem of finding free-boundary plasma equilibria within the context of MHD. The geometry is toroidal, and axisymmetry in the toroidal direction is assumed. We are led to conclude that the grid should move, not towards regions of high curvature of magnetic flux, but rather towards regions of greater toroidal current density. This has a direct bearing on the accuracy with which the Grad-Shafranov equation is being approximated

  17. Improved Simulation of Electrodiffusion in the Node of Ranvier by Mesh Adaptation.

    Science.gov (United States)

    Dione, Ibrahima; Deteix, Jean; Briffard, Thomas; Chamberland, Eric; Doyon, Nicolas

    2016-01-01

    In neural structures with complex geometries, numerical resolution of the Poisson-Nernst-Planck (PNP) equations is necessary to accurately model electrodiffusion. This formalism allows one to describe ionic concentrations and the electric field (even away from the membrane) with arbitrary spatial and temporal resolution which is impossible to achieve with models relying on cable theory. However, solving the PNP equations on complex geometries involves handling intricate numerical difficulties related either to the spatial discretization, temporal discretization or the resolution of the linearized systems, often requiring large computational resources which have limited the use of this approach. In the present paper, we investigate the best ways to use the finite elements method (FEM) to solve the PNP equations on domains with discontinuous properties (such as occur at the membrane-cytoplasm interface). 1) Using a simple 2D geometry to allow comparison with analytical solution, we show that mesh adaptation is a very (if not the most) efficient way to obtain accurate solutions while limiting the computational efforts, 2) We use mesh adaptation in a 3D model of a node of Ranvier to reveal details of the solution which are nearly impossible to resolve with other modelling techniques. For instance, we exhibit a non linear distribution of the electric potential within the membrane due to the non uniform width of the myelin and investigate its impact on the spatial profile of the electric field in the Debye layer. PMID:27548674

  18. Adapting SimpleTreat for simulating behaviour of chemical substances during industrial sewage treatment.

    Science.gov (United States)

    Struijs, J; van de Meent, D; Schowanek, D; Buchholz, H; Patoux, R; Wolf, T; Austin, T; Tolls, J; van Leeuwen, K; Galay-Burgos, M

    2016-09-01

    The multimedia model SimpleTreat, evaluates the distribution and elimination of chemicals by municipal sewage treatment plants (STP). It is applied in the framework of REACH (Registration, Evaluation, Authorization and Restriction of Chemicals). This article describes an adaptation of this model for application to industrial sewage treatment plants (I-STP). The intended use of this re-parametrized model is focused on risk assessment during manufacture and subsequent uses of chemicals, also in the framework of REACH. The results of an inquiry on the operational characteristics of industrial sewage treatment installations were used to re-parameterize the model. It appeared that one property of industrial sewage, i.e. Biological Oxygen Demand (BOD) in combination with one parameter of the activated sludge process, the hydraulic retention time (HRT) is satisfactory to define treatment of industrial wastewater by means of the activated sludge process. The adapted model was compared to the original municipal version, SimpleTreat 4.0, by means of a sensitivity analysis. The consistency of the model output was assessed by computing the emission to water from an I-STP of a set of fictitious chemicals. This set of chemicals exhibit a range of physico-chemical and biodegradability properties occurring in industrial wastewater. Predicted removal rates of a chemical from raw sewage are higher in industrial than in municipal STPs. The latter have typically shorter hydraulic retention times with diminished opportunity for elimination of the chemical due to volatilization and biodegradation. PMID:27344605

  19. Spectrally resolved bioluminescence tomography with adaptive finite element analysis: methodology and simulation

    International Nuclear Information System (INIS)

    As a molecular imaging technique, bioluminescence tomography (BLT) with its highly sensitive detection and facile operation can significantly reveal molecular and cellular information in vivo at the whole-body small animal level. However, because of complex photon transportation in biological tissue and boundary detection data with high noise, bioluminescent sources in deeper positions generally cannot be localized. In our previous work, we used achromatic or monochromatic measurements and an a priori permissible source region strategy to develop a multilevel adaptive finite-element algorithm. In this paper, we propose a spectrally solved tomographic algorithm with a posteriori permissible source region selection. Multispectral measurements, and anatomical and optical information first deal with the nonuniqueness of BLT and constrain the possible solution of source reconstruction. The use of adaptive mesh refinement and permissible source region based on a posteriori measures not only avoids the dimension disaster arising from the multispectral measured data but also reduces the ill-posedness of BLT and therefore improves the reconstruction quality. Reconsideration of the optimization method and related modifications further enhance reconstruction robustness and efficiency. We also incorporate into the method some improvements for reducing computational burdens. Finally, using a whole-body virtual mouse phantom, we demonstrate the capability of the proposed BLT algorithm to reconstruct accurately bioluminescent sources in deeper positions. In terms of optical property errors and two sources of discernment in deeper positions, this BLT algorithm represents the unique predominance for BLT reconstruction

  20. Evolution in Lego. A physical simulation of adaptation by natural selection

    DEFF Research Database (Denmark)

    Christensen-Dalsgaard, Jakob; Kanneworff, Morten

    2009-01-01

    En simulering af mekanismen bag naturlig udvælgelse ved at bruge legorger, organismer bygget af 6 legoklodser, og med en genetisk kode, der bestemmer hvordan klodserne er placeret og dermed formen på dyret. Legorgerne tildeles fitness efter, hvor langt de kan bevæge sig. Efter fem generationers s...

  1. Simulating the impact of climate change on rice production in Asia and evaluating options for adaptation.

    NARCIS (Netherlands)

    Matthews, R.B.; Kropff, M.J.; Horie, T.; Bachelet, D.

    1997-01-01

    The likely effects of climate change caused by increasing atmospheric carbon dioxide levels on rice production in Asia were evaluated using two rice crop simulation models, ORYZA1 and SIMRIW, running under fixed-change' climate scenarios and scenarios predicted for a doubled-CO2 (2xCO2) atmosphere b

  2. Adaptive multi-rate interface: development and experimental verification for real-time hybrid simulation

    DEFF Research Database (Denmark)

    Maghareh, Amin; Waldbjørn, Jacob Paamand; Dyke, Shirley J.;

    2016-01-01

    Real-time hybrid simulation (RTHS) is a powerful cyber-physical technique that is a relatively cost-effective method to perform global/local system evaluation of structural systems. A major factor that determines the ability of an RTHS to represent true system-level behavior is the fidelity...

  3. High performance pseudo-analytical simulation of multi-object adaptive optics over multi-GPU systems

    KAUST Repository

    Abdelfattah, Ahmad M.

    2014-01-01

    Multi-object adaptive optics (MOAO) is a novel adaptive optics (AO) technique dedicated to the special case of wide-field multi-object spectrographs (MOS). It applies dedicated wavefront corrections to numerous independent tiny patches spread over a large field of view (FOV). The control of each deformable mirror (DM) is done individually using a tomographic reconstruction of the phase based on measurements from a number of wavefront sensors (WFS) pointing at natural and artificial guide stars in the field. The output of this study helps the design of a new instrument called MOSAIC, a multi-object spectrograph proposed for the European Extremely Large Telescope (E-ELT). We have developed a novel hybrid pseudo-analytical simulation scheme that allows us to accurately simulate in detail the tomographic problem. The main challenge resides in the computation of the tomographic reconstructor, which involves pseudo-inversion of a large dense symmetric matrix. The pseudo-inverse is computed using an eigenvalue decomposition, based on the divide and conquer algorithm, on multicore systems with multi-GPUs. Thanks to a new symmetric matrix-vector product (SYMV) multi-GPU kernel, our overall implementation scores significant speedups over standard numerical libraries on multicore, like Intel MKL, and up to 60% speedups over the standard MAGMA implementation on 8 Kepler K20c GPUs. At 40,000 unknowns, this appears to be the largest-scale tomographic AO matrix solver submitted to computation, to date, to our knowledge and opens new research directions for extreme scale AO simulations. © 2014 Springer International Publishing Switzerland.

  4. Virtual World Learning Spaces: Developing a Second Life Operating Room Simulation

    Science.gov (United States)

    Gerald, Stephanie; Antonacci, David M.

    2009-01-01

    User-created virtual worlds, such as Second Life, are a hot topic in higher education. Thousands of educators are currently exploring and using Second Life, and hundreds of colleges and universities have purchased and developed their own private islands in Second Life, including the University of Kansas Medical Center (KUMC). Because it is so easy…

  5. Nuclear power plant status diagnostics using simulated condensation: An auto-adaptive computer learning technique

    International Nuclear Information System (INIS)

    The application of artificial neural network concepts to engineering analysis involves training networks, and therefore computers, to perform pattern classification or function mapping tasks. This training process requires the near optimization of network inter-neural connections. A new method for the stochastic optimization of these interconnections is presented in this dissertation. The new approach, called simulated condensation, is applied to networks of generalized, fully interconnected, continuous preceptrons. Simulated condensation optimizes the nodal bias, gain, and output activation constants as well as the usual interconnection weights. In this work, the simulated condensation network paradigm is applied to nuclear power plant operating status recognition. A set of standard problems such as the exclusive-or problem and others are also analyzed as benchmarks for the new methodology. The objective of the nuclear power plant accidient condition diagnosis effort is to train a network to identify both safe and potentially unsafe power plant conditions based on real time plant data. The data is obtained from computer generated accident scenarios. A simulated condensation network is trained to recognize seven nuclear power plant accident conditions as well as the normal full power operating condition. These accidents include, hot and cold leg loss of coolant, control rod ejection and steam generator tube leak accidents. Twenty-seven plant process variables are used as input to the neural network. Results show the feasibility of using simulated condensation as a method for diagnosing nuclear power plant conditions. The method is general and can easily be applied to other types of plants and plant processes

  6. Adaptation of Gabor filters for simulation of human preattentive mechanism for a mobile robot

    Science.gov (United States)

    Kulkarni, Naren; Naghdy, Golshah A.

    1993-08-01

    Vision guided mobile robot navigation is complex and requires analysis of tremendous amounts of information in real time. In order to simplify the task and reduce the amount of information, human preattentive mechanism can be adapted [Nag90]. During the preattentive search the scene is analyzed rapidly but in sufficient detail for the attention to be focused on the `area of interest.' The `area of interest' can further be scrutinized in more detail for recognition purposes. This `area of interest' can be a text message to facilitate navigation. Gabor filters and an automated turning mechanism are used to isolate the `area of interest.' These regions are subsequently processed with optimal spatial resolution for perception tasks. This method has clear advantages over the global operators in that, after an initial search, it scans each region of interest with optimum resolution. This reduces the volume of information for recognition stages and ensures that no region is over or under estimated.

  7. The Ten Commandments for Translating Simulation Results into Real-Life Performance

    Science.gov (United States)

    Wenzler, Ivo

    2009-01-01

    Simulation designers are continuously facing the challenge of determining how much of the expected value the simulation has delivered to the client. Addressing this challenge is not easy, and it requires simulation designers to stretch their comfort zones. This article presents a ten-step approach for meeting simulation objectives and translating…

  8. Assessment of the Impacts of ACLS on the ISS Life Support System using Dynamic Simulations in V-HAB

    Science.gov (United States)

    Puetz, Daniel; Olthoff, Claas; Ewert, Michael K.; Anderson, Molly S.

    2016-01-01

    The Advanced Closed Loop System (ACLS) is currently under development by Airbus Defense and Space and is slated for launch to the International Space Station (ISS) in 2017. The addition of new hardware into an already complex system such as the ISS life support system (LSS) always poses operational risks. It is therefore important to understand the impacts ACLS will have on the existing systems to ensure smooth operations for the ISS. This analysis can be done by using dynamic computer simulations and one possible tool for such a simulation is Virtual Habitat (V-HAB). Based on Matlab (Registered Trademark) V-HAB has been under development at the Institute of Astronautics of the Technical University Munich (TUM) since 2006 and in the past has been successfully used to simulate the ISS life support systems. The existing V-HAB ISS simulation model treated the interior volume of the space station as one large ideally-stirred container. This model was improved to allow the calculation of the atmospheric composition inside the individual modules of the ISS by splitting it into ten distinct volumes. The virtual volumes are connected by a simulation of the inter-module ventilation flows. This allows for a combined simulation of the LSS hardware and the atmospheric composition aboard the ISS. A dynamic model of ACLS is added to the ISS simulation and different operating modes for both ACLS and the existing ISS life support systems are studied to determine the impacts of ACLS on the rest of the system. The results suggest that the US, Russian and ACLS CO2 systems can operate at the same time without impeding each other. Furthermore, based on the results of this analysis, the US and ACLS Sabatier systems can be operated in parallel as well to achieve the highest possible CO2 recycling together with a low CO2 concentration.

  9. Six thinking hats for electricity markets simulation: adapting meeting tools to agent decision

    OpenAIRE

    Barreto, João Costa Borges

    2012-01-01

    In almost all industrialized countries, the energy sector has suffered a severe restructuring that originated a greater complexity in market players’ interactions. The complexity that these changes brought made way for the creation of decision support tools that facilitate the study and understanding of these markets. MASCEM – “Multiagent Simulator for Competitive Electricity Markets” arose in this context providing a framework for evaluating new rules, new behaviour, and new participants ...

  10. MOSAIIC : City-Level Agent-Based Traffic Simulation Adapted to Emergency Situations

    OpenAIRE

    Czura, Guillaume; Taillandier, Patrick; Tranouez, Pierrick; Daudé, Éric

    2015-01-01

    International audience In this paper, we present MOSAIIC, an agent-based model to simulate the road traffic of a city in the context of a catastrophic event. Whether natural (cyclone, earthquake, flood) or human (industrial accident) in origin, catastrophic situations modify both infrastructures (buildings, road networks) and human behaviors, which can have a huge impact on human safety. Because the heterogeneities of human behaviors, of land- uses and of network topology have a great impa...

  11. Adaptive mesh refinement and automatic remeshing in crystal plasticity finite element simulations

    International Nuclear Information System (INIS)

    In finite element simulations dedicated to the modelling of microstructure evolution, the mesh has to be fine enough to: (i) accurately describe the geometry of the constituents; (ii) capture local strain gradients stemming from the heterogeneity in material properties. In this paper, 3D polycrystalline aggregates are discretized into unstructured meshes and a level set framework is used to represent the grain boundaries. The crystal plasticity finite element method is used to simulate the plastic deformation of these aggregates. A mesh sensitivity analysis based on the deformation energy distribution shows that the predictions are, on average, more sensitive near grain boundaries. An anisotropic mesh refinement strategy based on the level set description is introduced and it is shown that it offers a good compromise between accuracy requirements on the one hand and computation time on the other hand. As the aggregates deform, mesh distortion inevitably occurs and ultimately causes the breakdown of the simulations. An automatic remeshing tool is used to periodically reconstruct the mesh and appropriate transfer of state variables is performed. It is shown that the diffusion related to data transfer is not significant. Finally, remeshing is performed repeatedly in a highly resolved 500 grains polycrystal subjected to about 90% thickness reduction in rolling. The predicted texture is compared with the experimental data and with the predictions of a standard Taylor model

  12. A simulation tool for integrating climate change and Canadian surface transport : towards assessing impacts and adaptations

    International Nuclear Information System (INIS)

    Extreme weather events resulting from climate change will have a significant impact of the performance of the Canadian transportation system. This presentation described a simulation tool designed to investigate the potential ramifications of future climate change on transportation and the economy. The CLIMATE-C tool was designed to simulate future weather scenarios for the years 2020 and 2050 using weather parameters obtained from a global general circulation model. The model accounted for linkages between weather, transportation, and economic systems. A random utility-based multi-regional input-output model was used to predict inter-regional trade flows by truck and rail in Canada. Simulated weather scenarios were used to describe predicted changes in demographic, social, economic, technological and environmental developments to 2100. Various changes in population and economic growth were considered. Six additional scenarios were formulated to consider moderate and high rainfall events, moderate, high and extreme snowfall, and cold temperatures. Results of the preliminary analysis indicated that the model is sensitive to changes in weather events. Future research is needed to evaluate future weather scenarios and analyze weather-transport data in order to quantify travel speed reduction parameters. tabs., figs.

  13. Numerical simulation of the slip power recovery system using functional adapted blocks

    Energy Technology Data Exchange (ETDEWEB)

    Marques, G.D. [Technical University of Lisbon, Instituto Superior Tecnico, Seccao de Maquinas Electricas e de Electronica de Potencia, Lisboa (Portugal)

    2000-08-01

    This paper presents a numerical simulation method for the Slip Power Recovery System. The dq induction machine model using stator flux linkages as state variables is used. This leads to a simple and efficient computer program. The diode bridge rectifier is modeled using three switching functions that are determined by the sign of the corresponding AC currents. The model obtained is very simple and accurately represents the three-phase diode bridge rectifier including the current commutation process. When a DC current circuit is used in the intermediate circuit, a model of the whole 'Induction machine and diode bridge rectifier' should be used in other simulation methods. In this paper a different approach is presented. The operations performed to model the system are equivalent to assume that the induction machine has two state variables, i.e, the stator flux linkages. From the rotor point of view, the induction machine is equivalent to a three-phase RLE circuit. MATLAB/Simulink is used to integrate the equations. Experimental and simulated results are presented and compared showing good accuracy. (orig.)

  14. Adapting a commercial power system simulator for smart grid based system study and vulnerability assessment

    Science.gov (United States)

    Navaratne, Uditha Sudheera

    The smart grid is the future of the power grid. Smart meters and the associated network play a major role in the distributed system of the smart grid. Advance Metering Infrastructure (AMI) can enhance the reliability of the grid, generate efficient energy management opportunities and many innovations around the future smart grid. These innovations involve intense research not only on the AMI network itself but as also on the influence an AMI network can have upon the rest of the power grid. This research describes a smart meter testbed with hardware in loop that can facilitate future research in an AMI network. The smart meters in the testbed were developed such that their functionality can be customized to simulate any given scenario such as integrating new hardware components into a smart meter or developing new encryption algorithms in firmware. These smart meters were integrated into the power system simulator to simulate the power flow variation in the power grid on different AMI activities. Each smart meter in the network also provides a communication interface to the home area network. This research delivers a testbed for emulating the AMI activities and monitoring their effect on the smart grid.

  15. Changes in life satisfaction in persons with spinal cord injury during and after inpatient rehabilitation : adaptation or measurement bias?

    NARCIS (Netherlands)

    van Leeuwen, Christel M. C.; Post, Marcel W. M.; van der Woude, Lucas H. V.; de Groot, Sonja; Smit, Christof; van Kuppevelt, Dirk; Lindeman, Eline

    2012-01-01

    Purpose To analyze changes in life satisfaction (LS) scores over time in persons with spinal cord injury (SCI) and to interpret what these changes mean. Methods Multicenter, prospective cohort study of persons with SCI (n = 96) classified into 3 life satisfaction trajectories identified earlier. Ass

  16. Mexican Americans in Higher Education: Cultural Adaptation and Marginalization as Predictors of College Persistence Intentions and Life Satisfaction

    Science.gov (United States)

    Ojeda, Lizette; Castillo, Linda G.; Rosales Meza, Rocío; Piña-Watson, Brandy

    2014-01-01

    This study examined how college persistence intentions and life satisfaction influenced by acculturation, enculturation, White marginalization, and Mexican American marginalization among 515 Mexican American college students. The utility of a path analysis model was supported. Enculturation positively predicted persistence and life satisfaction.…

  17. Distributed cerebellar plasticity implements adaptable gain control in a manipulation task: a closed-loop robotic simulation

    Directory of Open Access Journals (Sweden)

    Jesus A Garrido Alcazar

    2013-10-01

    Full Text Available Adaptable gain regulation is at the core of the forward controller operation performed by the cerebro-cerebellar loops and it allows the intensity of motor acts to be finely tuned in a predictive manner. In order to learn and store information about body-object dynamics and to generate an internal model of movement, the cerebellum is thought to employ long-term synaptic plasticity. LTD at the PF-PC synapse has classically been assumed to subserve this function (Marr, 1969. However, this plasticity alone cannot account for the broad dynamic ranges and time scales of cerebellar adaptation. We therefore tested the role of plasticity distributed over multiple synaptic sites (Gao et al., 2012; Hansel et al., 2001 by generating an analog cerebellar model embedded into a control loop connected to a robotic simulator. The robot used a three-joint arm and performed repetitive fast manipulations with different masses along an 8-shape trajectory. In accordance with biological evidence, the cerebellum model was endowed with both LTD and LTP at the PF-PC, MF-DCN and PC-DCN synapses. This resulted in a network scheme whose effectiveness was extended considerably compared to one including just PF-PC synaptic plasticity. Indeed, the system including distributed plasticity reliably self-adapted to manipulate different masses and to learn the arm-object dynamics over a time course that included fast learning and consolidation, along the lines of what has been observed in behavioral tests. In particular, PF-PC plasticity operated as a time correlator between the actual input state and the system error, while MF-DCN and PC-DCN plasticity played a key role in generating the gain controller. This model suggests that distributed synaptic plasticity allows generation of the complex learning properties of the cerebellum. The incorporation of further plasticity mechanisms and of spiking signal processing will allow this concept to be extended in a more realistic

  18. Large Eddy simulation of compressible flows with a low-numerical dissipation patch-based adaptive mesh refinement method

    Science.gov (United States)

    Pantano, Carlos

    2005-11-01

    We describe a hybrid finite difference method for large-eddy simulation (LES) of compressible flows with a low-numerical dissipation scheme and structured adaptive mesh refinement (SAMR). Numerical experiments and validation calculations are presented including a turbulent jet and the strongly shock-driven mixing of a Richtmyer-Meshkov instability. The approach is a conservative flux-based SAMR formulation and as such, it utilizes refinement to computational advantage. The numerical method for the resolved scale terms encompasses the cases of scheme alternation and internal mesh interfaces resulting from SAMR. An explicit centered scheme that is consistent with a skew-symmetric finite difference formulation is used in turbulent flow regions while a weighted essentially non-oscillatory (WENO) scheme is employed to capture shocks. The subgrid stresses and transports are calculated by means of the streched-vortex model, Misra & Pullin (1997)

  19. Fluid flow and heat transfer investigation of pebble bed reactors using mesh adaptive large-eddy simulation

    International Nuclear Information System (INIS)

    A computational fluid dynamics model with anisotropic mesh adaptivity is used to investigate coolant flow and heat transfer in pebble bed reactors. A novel method for implicitly incorporating solid boundaries based on multi-fluid flow modelling is adopted. The resulting model is able to resolve and simulate flow and heat transfer in randomly packed beds, regardless of the actual geometry, starting off with arbitrarily coarse meshes. The model is initially evaluated using an orderly stacked square channel of channel-height-to-particle diameter ratio of unity for a range of Reynolds numbers. The model is then applied to the face-centred cubical geometry. Coolant flow and heat transfer patterns are investigated. (author)

  20. Simulation of underresolved turbulent flows by adaptive filtering using the high order discontinuous Galerkin spectral element method

    Science.gov (United States)

    Flad, David; Beck, Andrea; Munz, Claus-Dieter

    2016-05-01

    Scale-resolving simulations of turbulent flows in complex domains demand accurate and efficient numerical schemes, as well as geometrical flexibility. For underresolved situations, the avoidance of aliasing errors is a strong demand for stability. For continuous and discontinuous Galerkin schemes, an effective way to prevent aliasing errors is to increase the quadrature precision of the projection operator to account for the non-linearity of the operands (polynomial dealiasing, overintegration). But this increases the computational costs extensively. In this work, we present a novel spatially and temporally adaptive dealiasing strategy by projection filtering. We show this to be more efficient for underresolved turbulence than the classical overintegration strategy. For this novel approach, we discuss the implementation strategy and the indicator details, show its accuracy and efficiency for a decaying homogeneous isotropic turbulence and the transitional Taylor-Green vortex and compare it to the original overintegration approach and a state of the art variational multi-scale eddy viscosity formulation.

  1. Reduction in patient burdens with graphical computerized adaptive testing on the ADL scale: tool development and simulation

    Directory of Open Access Journals (Sweden)

    Wang Weng-Chung

    2009-05-01

    Full Text Available Abstract Background The aim of this study was to verify the effectiveness and efficacy of saving time and reducing burden for patients, nurses, and even occupational therapists through computer adaptive testing (CAT. Methods Based on an item bank of the Barthel Index (BI and the Frenchay Activities Index (FAI for assessing comprehensive activities of daily living (ADL function in stroke patients, we developed a visual basic application (VBA-Excel CAT module, and (1 investigated whether the averaged test length via CAT is shorter than that of the traditional all-item-answered non-adaptive testing (NAT approach through simulation, (2 illustrated the CAT multimedia on a tablet PC showing data collection and response errors of ADL clinical functional measures in stroke patients, and (3 demonstrated the quality control of endorsing scale with fit statistics to detect responding errors, which will be further immediately reconfirmed by technicians once patient ends the CAT assessment. Results The results show that endorsed items could be shorter on CAT (M = 13.42 than on NAT (M = 23 at 41.64% efficiency in test length. However, averaged ability estimations reveal insignificant differences between CAT and NAT. Conclusion This study found that mobile nursing services, placed at the bedsides of patients could, through the programmed VBA-Excel CAT module, reduce the burden to patients and save time, more so than the traditional NAT paper-and-pencil testing appraisals.

  2. Gamma-Ray Burst Dynamics and Afterglow Radiation from Adaptive Mesh Refinement, Special Relativistic Hydrodynamic Simulations

    CERN Document Server

    De Colle, Fabio; Lopez-Camara, Diego; Ramirez-Ruiz, Enrico

    2011-01-01

    We report on the development of Mezcal-SRHD, a new adaptive mesh refinement, special relativistic hydrodynamics (SRHD) code, developed with the aim of studying the highly relativistic flows in Gamma-Ray Burst sources. The SRHD equations are solved using finite volume conservative solvers. The correct implementation of the algorithms is verified by one-dimensional (1D) shock tube and multidimensional tests. The code is then applied to study the propagation of 1D spherical impulsive blast waves expanding in a stratified medium with $\\rho \\propto r^{-k}$, bridging between the relativistic and Newtonian phases, as well as to a two-dimensional (2D) cylindrically symmetric impulsive jet propagating in a constant density medium. It is shown that the deceleration to non-relativistic speeds in one-dimension occurs on scales significantly larger than the Sedov length. This transition is further delayed with respect to the Sedov length as the degree of stratification of the ambient medium is increased. This result, toge...

  3. Study of the psychological adaptation of the crew during a 135 days space simulation

    Science.gov (United States)

    Elisabeth, Rosnet; Geneviève, Cazes; Alla, Venokhodova

    The purpose of this study is to examine human Actaptation of a three members' crew during a 135 days MIR flight simulation and to compare and validate psychological methods for monitoring and support in flight. The main findings showed that isolation was not a key factor for the subjects who were more concerned by recreational activities, family, and work. The individual reactions to stress of the crew members were to project their problems on the others. These reactions had some consequences upon the group: Although the three subjects developed a weak tendency to ≪ group think ≫, one of the crew members was considered as less integrated to the group by me other two subjects, who, however, acted to protect (successfully) the general cohesion and mood of the crew. From a methodological point of view, baseline data predicted the difficulties that occurred for one of the crew member. Bom quantitative and qualitative tools were adequate, although qualitative tests gave a closer approach to the actual situation that developed during the simulation.

  4. Finite domain simulations with adaptive boundaries: Accurate potentials and nonequilibrium movesets

    Science.gov (United States)

    Wagoner, Jason A.; Pande, Vijay S.

    2013-12-01

    We extend the theory of hybrid explicit/implicit solvent models to include an explicit domain that grows and shrinks in response to a solute's evolving configuration. The goal of this model is to provide an appropriate but not excessive amount of solvent detail, and the inclusion of an adjustable boundary provides a significant computational advantage for solutes that explore a range of configurations. In addition to the theoretical development, a successful implementation of this method requires (1) an efficient moveset that propagates the boundary as a new coordinate of the system, and (2) an accurate continuum solvent model with parameters that are transferable to an explicit domain of any size. We address these challenges and develop boundary updates using Monte Carlo moves biased by nonequilibrium paths. We obtain the desired level of accuracy using a "decoupling interface" that we have previously shown to remove boundary artifacts common to hybrid solvent models. Using an uncharged, coarse-grained solvent model, we then study the efficiency of nonequilibrium paths that a simulation takes by quantifying the dissipation. In the spirit of optimization, we study this quantity over a range of simulation parameters.

  5. The value of the qualitative method for adaptation of a disease-specific quality of life assessment instrument: the case of the Rheumatoid Arthritis Quality of Life Scale (RAQoL in Estonia

    Directory of Open Access Journals (Sweden)

    Maimets Kadri

    2004-12-01

    Full Text Available Abstract Background Due to differences in current socio-economical situation and historically shaped values, different societies have their own concepts of high-quality life. This diversity of concepts interferes with quality of life (Qol research in health sciences. Before deciding to apply a Qol assessment tool designed in and for another society, a researcher should answer the question: how will this instrument work under the specific circumstances of my research. Our study represents an example of the utilization of qualitative research methods to investigate the appropriateness of the Rheumatoid Arthritis Quality of Life Scale (RAQol for the assessment of Qol in Estonian patients. Methods Semi-structured interviews were conducted with the rheumatoid arthritis (RA patients of Tartu University Hospital and these were analyzed using the principles of the grounded theory. Results We described the significance of the questionnaire's items for our patients and also identified topics that were important for the Qol of Estonian RA patients, but that were not assessed by the RAQol. We concluded that the RAQol can be successfully adapted for Estonia; the aspects of Qol not captured by the questionnaire but revealed during our study should be taken into account in future research. Conclusions Our results show that qualitative research can successfully be used for pre-adaptation assessment of a Qol instrument's appropriateness.

  6. The Role of Identity Integration in Hedonic Adaptation to a Beneficial Life Change: The Example of "Coming Out" for Lesbians and Gay Men.

    Science.gov (United States)

    Coulombe, Simon; de la Sablonnière, Roxane

    2015-01-01

    After apparently beneficial life changes, people are expected to experience elevated well-being. However, research suggests that some individuals adapt quickly to change, so their well-being increases little in the long-term. We propose this phenomenon is explained by the integration of the changes into identity, in interaction with perceived valence of the changes. We hypothesized that higher integration would be associated with smaller increases in well-being for changes perceived as positive. For changes perceived as negative, higher integration would be associated with larger increases in well-being. Lesbians and gay men (N = 80) completed a questionnaire on well-being, perceived valence of coming out and its integration into identity. Moderated regressions supported the hypotheses, revealing the importance of considering identity integration and perceived valence in research on adaptation to changes. The results question the merits of interventions promoting identity integration.

  7. The Role of Identity Integration in Hedonic Adaptation to a Beneficial Life Change: The Example of "Coming Out" for Lesbians and Gay Men.

    Science.gov (United States)

    Coulombe, Simon; de la Sablonnière, Roxane

    2015-01-01

    After apparently beneficial life changes, people are expected to experience elevated well-being. However, research suggests that some individuals adapt quickly to change, so their well-being increases little in the long-term. We propose this phenomenon is explained by the integration of the changes into identity, in interaction with perceived valence of the changes. We hypothesized that higher integration would be associated with smaller increases in well-being for changes perceived as positive. For changes perceived as negative, higher integration would be associated with larger increases in well-being. Lesbians and gay men (N = 80) completed a questionnaire on well-being, perceived valence of coming out and its integration into identity. Moderated regressions supported the hypotheses, revealing the importance of considering identity integration and perceived valence in research on adaptation to changes. The results question the merits of interventions promoting identity integration. PMID:25607247

  8. Effectiveness of a poverty simulation in Second Life®: changing nursing student attitudes toward poor people.

    Science.gov (United States)

    Menzel, Nancy; Willson, Laura Helen; Doolen, Jessica

    2014-01-01

    Social justice is a fundamental value of the nursing profession, challenging educators to instill this professional value when caring for the poor. This randomized controlled trial examined whether an interactive virtual poverty simulation created in Second Life® would improve nursing students' empathy with and attributions for people living in poverty, compared to a self-study module. We created a multi-user virtual environment populated with families and individual avatars that represented the demographics contributing to poverty and vulnerability. Participants (N = 51 baccalaureate nursing students) were randomly assigned to either Intervention or Control groups and completed the modified Attitudes toward Poverty Scale pre- and post-intervention. The 2.5-hour simulation was delivered three times over a 1-year period to students in successive community health nursing classes. The investigators conducted post-simulation debriefings following a script. While participants in the virtual poverty simulation developed significantly more favorable attitudes on five questions than the Control group, the total scores did not differ significantly. Whereas students readily learned how to navigate inside Second Life®, faculty facilitators required periodic coaching and guidance to be competent. While poverty simulations, whether virtual or face-to-face, have some ability to transform nursing student attitudes, faculty must incorporate social justice concepts throughout the curriculum to produce lasting change.

  9. Survival and Germinability of Bacillus subtilis Spores Exposed to Simulated Mars Solar Radiation: Implications for Life Detection and Planetary Protection

    Science.gov (United States)

    Tauscher, Courtney; Schuerger, Andrew C.; Nicholson, Wayne L.

    2006-08-01

    Bacterial spores have been considered as microbial life that could survive interplanetary transport by natural impact processes or human spaceflight activity. Deposition of terrestrial microbes or their biosignature molecules onto the surface of Mars could negatively impact life detection experiments and planetary protection measures. Simulated Mars solar radiation, particularly the ultraviolet component, has been shown to reduce spore viability, but its effect on spore germination and resulting production of biosignature molecules has not been explored. We examined the survival and germinability of Bacillus subtilis spores exposed to simulated martian conditions that include solar radiation. Spores of B. subtilis that contain luciferase resulting from expression of an sspB-luxAB gene fusion were deposited on aluminum coupons to simulate deposition on spacecraft surfaces and exposed to simulated Mars atmosphere and solar radiation. The equivalent of 42 min of simulated Mars solar radiation exposure reduced spore viability by nearly 3 logs, while germination-induced bioluminescence, a measure of germination metabolism, was reduced by less than 1 log. The data indicate that spores can retain the potential to initiate germination-associated metabolic processes and produce biological signature molecules after being rendered nonviable by exposure to Mars solar radiation.

  10. Tree-Particle-Mesh an adaptive, efficient, and parallel code for collisionless cosmological simulation

    CERN Document Server

    Bode, P; Bode, Paul; Ostriker, Jeremiah P.

    2003-01-01

    An improved implementation of an N-body code for simulating collisionless cosmological dynamics is presented. TPM (Tree-Particle-Mesh) combines the PM method on large scales with a tree code to handle particle-particle interactions at small separations. After the global PM forces are calculated, spatially distinct regions above a given density contrast are located; the tree code calculates the gravitational interactions inside these denser objects at higher spatial and temporal resolution. The new implementation includes individual particle time steps within trees, an improved treatment of tidal forces on trees, new criteria for higher force resolution and choice of time step, and parallel treatment of large trees. TPM is compared to P^3M and a tree code (GADGET) and is found to give equivalent results in significantly less time. The implementation is highly portable (requiring a Fortran compiler and MPI) and efficient on parallel machines. The source code can be found at http://astro.princeton.edu/~bode/TPM/

  11. Adaptation and Performance of the Cartesian Coordinates Fast Multipole Method for Nanomagnetic Simulations

    CERN Document Server

    Zhang, Wen

    2008-01-01

    An implementation of the fast multiple method (FMM) is performed for magnetic systems with long-ranged dipolar interactions. Expansion in spherical harmonics of the original FMM is replaced by expansion of polynomials in cartesian coordinates, which is considerably simpler. Under open boundary conditions, an expression for multipole moments of point dipoles in a cell is derived. These make the program appropriate for nanomagnetic simulations, including magnetic nanoparticles and ferrofluids. The performance is optimized in terms of cell size and parameter set (expansion order and opening angle) and trade off between computing time and accuracy is quantitatively studied. A rule of thumb is proposed to decide the average number of dipoles in the smallest cells, and an optimal choice of parameter set is suggested.

  12. The Influence of Motivation and Adaptation on Students' Subjective Well-Being, Meaning in Life and Academic Performance

    Science.gov (United States)

    Bailey, Thomas Hamilton; Phillips, Lisa J.

    2016-01-01

    High rates of mental illness among students and discontinuation with university studies are regularly reported. The current study sought to explore relationships between motivation, university adaptation and indicators of mental health and well-being and academic performance of 184 first-year university students (73% female, mean age?=?19.3…

  13. Economic, energy and environmental evaluations of biomass-based fuel ethanol projects based on life cycle assessment and simulation

    International Nuclear Information System (INIS)

    This paper summarizes the research of Monte Carlo simulation-based Economic, Energy and Environmental (3E) Life Cycle Assessment (LCA) of the three Biomass-based Fuel Ethanol (BFE) projects in China. Our research includes both theoretical study and case study. In the theoretical study part, 3E LCA models are structured, 3E Index Functions are defined and the Monte Carlo simulation is introduced to address uncertainties in BFE life cycle analysis. In the case study part, projects of Wheat-based Fuel Ethanol (WFE) in Central China, Corn-based Fuel Ethanol (CFE) in Northeast China, and Cassava-based Fuel Ethanol (CFE) in Southwest China are evaluated from the aspects of economic viability and investment risks, energy efficiency and airborne emissions. The life cycle economy assessment shows that KFE project in Guangxi is viable, while CFE and WFE projects are not without government's subsidies. Energy efficiency assessment results show that WFE, CFE and KFE projects all have positive Net Energy Values. Emissions results show that the corn-based E10 (a blend of 10% gasoline and 90% ethanol by volume), wheat-based E10 and cassava-base E10 have less CO2 and VOC life cycle emissions than conventional gasoline, but wheat-based E10 and cassava-based E10 can generate more emissions of CO, CH4, N2O, NOx, SO2, PM10 and corn-based E10 can has more emissions of CH4, N2O, NOx, SO, PM10.

  14. An Immersed Boundary - Adaptive Mesh Refinement solver (IB-AMR) for high fidelity fully resolved wind turbine simulations

    Science.gov (United States)

    Angelidis, Dionysios; Sotiropoulos, Fotis

    2015-11-01

    The geometrical details of wind turbines determine the structure of the turbulence in the near and far wake and should be taken in account when performing high fidelity calculations. Multi-resolution simulations coupled with an immersed boundary method constitutes a powerful framework for high-fidelity calculations past wind farms located over complex terrains. We develop a 3D Immersed-Boundary Adaptive Mesh Refinement flow solver (IB-AMR) which enables turbine-resolving LES of wind turbines. The idea of using a hybrid staggered/non-staggered grid layout adopted in the Curvilinear Immersed Boundary Method (CURVIB) has been successfully incorporated on unstructured meshes and the fractional step method has been employed. The overall performance and robustness of the second order accurate, parallel, unstructured solver is evaluated by comparing the numerical simulations against conforming grid calculations and experimental measurements of laminar and turbulent flows over complex geometries. We also present turbine-resolving multi-scale LES considering all the details affecting the induced flow field; including the geometry of the tower, the nacelle and especially the rotor blades of a wind tunnel scale turbine. This material is based upon work supported by the Department of Energy under Award Number DE-EE0005482 and the Sandia National Laboratories.

  15. Numerical simulation of four-field extended magnetohydrodynamics in dynamically adaptive curvilinear coordinates via Newton-Krylov-Schwarz

    KAUST Repository

    Yuan, Xuefei

    2012-07-01

    Numerical simulations of the four-field extended magnetohydrodynamics (MHD) equations with hyper-resistivity terms present a difficult challenge because of demanding spatial resolution requirements. A time-dependent sequence of . r-refinement adaptive grids obtained from solving a single Monge-Ampère (MA) equation addresses the high-resolution requirements near the . x-point for numerical simulation of the magnetic reconnection problem. The MHD equations are transformed from Cartesian coordinates to solution-defined curvilinear coordinates. After the application of an implicit scheme to the time-dependent problem, the parallel Newton-Krylov-Schwarz (NKS) algorithm is used to solve the system at each time step. Convergence and accuracy studies show that the curvilinear solution requires less computational effort than a pure Cartesian treatment. This is due both to the more optimal placement of the grid points and to the improved convergence of the implicit solver, nonlinearly and linearly. The latter effect, which is significant (more than an order of magnitude in number of inner linear iterations for equivalent accuracy), does not yet seem to be widely appreciated. © 2012 Elsevier Inc.

  16. Simulating anchovy's full life cycle in the northern Aegean Sea (eastern Mediterranean): A coupled hydro-biogeochemical-IBM model

    Science.gov (United States)

    Politikos, D.; Somarakis, S.; Tsiaras, K. P.; Giannoulaki, M.; Petihakis, G.; Machias, A.; Triantafyllou, G.

    2015-11-01

    A 3-D full life cycle population model for the North Aegean Sea (NAS) anchovy stock is presented. The model is two-way coupled with a hydrodynamic-biogeochemical model (POM-ERSEM). The anchovy life span is divided into seven life stages/age classes. Embryos and early larvae are passive particles, but subsequent stages exhibit active horizontal movements based on specific rules. A bioenergetics model simulates the growth in both the larval and juvenile/adult stages, while the microzooplankton and mesozooplankton fields of the biogeochemical model provide the food for fish consumption. The super-individual approach is adopted for the representation of the anchovy population. A dynamic egg production module, with an energy allocation algorithm, is embedded in the bioenergetics equation and produces eggs based on a new conceptual model for anchovy vitellogenesis. A model simulation for the period 2003-2006 with realistic initial conditions reproduced well the magnitude of population biomass and daily egg production estimated from acoustic and daily egg production method (DEPM) surveys, carried out in the NAS during June 2003-2006. Model simulated adult and egg habitats were also in good agreement with observed spatial distributions of acoustic biomass and egg abundance in June. Sensitivity simulations were performed to investigate the effect of different formulations adopted for key processes, such as reproduction and movement. The effect of the anchovy population on plankton dynamics was also investigated, by comparing simulations adopting a two-way or a one-way coupling of the fish with the biogeochemical model.

  17. WASCAL - West African Science Service Center on Climate Change and Adapted Land Use Regional Climate Simulations and Land-Atmosphere Simulations for West Africa at DKRZ and elsewhere

    Science.gov (United States)

    Hamann, Ilse; Arnault, Joel; Bliefernicht, Jan; Klein, Cornelia; Heinzeller, Dominikus; Kunstmann, Harald

    2014-05-01

    Changing climate and hydro-meteorological boundary conditions are among the most severe challenges to Africa in the 21st century. In particular West Africa faces an urgent need to develop effective adaptation and mitigation strategies to cope with negative impacts on humans and environment due to climate change, increased hydro-meteorological variability and land use changes. To help meet these challenges, the German Federal Ministry of Education and Research (BMBF) started an initiative with institutions in Germany and West African countries to establish together a West African Science Service Center on Climate Change and Adapted Land Use (WASCAL). This activity is accompanied by an establishment of trans-boundary observation networks, an interdisciplinary core research program and graduate research programs on climate change and related issues for strengthening the analytical capabilities of the Science Service Center. A key research activity of the WASCAL Competence Center is the provision of regional climate simulations in a fine spatio-temporal resolution for the core research sites of WASCAL for the present and the near future. The climate information is needed for subsequent local climate impact studies in agriculture, water resources and further socio-economic sectors. The simulation experiments are performed using regional climate models such as COSMO-CLM, RegCM and WRF and statistical techniques for a further refinement of the projections. The core research sites of WASCAL are located in the Sudanian Savannah belt in Northern Ghana, Southern Burkina Faso and Northern Benin. The climate in this region is semi-arid with six rainy months. Due to the strong population growth in West Africa, many areas of the Sudanian Savannah have been already converted to farmland since the majority of the people are living directly or indirectly from the income produced in agriculture. The simulation experiments of the Competence Center and the Core Research Program are

  18. Summary of Research Adaptions of Visceral and Cerebral Resistance Arteries to Simulated Microgravity

    Science.gov (United States)

    Delp, Michael

    2003-01-01

    The proposed studies were designed address the effects of simulated microgravity on vascular smooth muscle and endothelial cell function in resistance arteries isolated from visceral tissues (spleen, mesentery and kidneys) and cerebrum. Alterations in vascular function induced by microgravity are particularly relevant to the problems of orthostatic intolerance and reduced exercise capacity experienced by astronauts upon re-entry into the earth's gravitational field. Decrements in contractile function or enhanced vasodilatory responsiveness of peripheral resistance arteries could lead to decreased peripheral resistance and orthostatic hypotension. Alternatively, augmentation of contractile function in cerebral resistance arteries could lead to increased cerebral vascular resistance and diminished perfusion of the brain. The Specific Aims and hypotheses were proposed in this grant. Following each of the Specific Aims, progress toward addressing that specific aim is presented. With the exception of Specific Aim VI (see aim for details), all aims have been experimentally addressed as proposed. The final six months of the granting period will be used for manuscript preparation; manuscripts in preparation will contain results from Specific Aims I-IV. Results from Specific Aims V and VI have been published.

  19. Asperger syndrome and "non-verbal learning problems" in a longitudinal perspective: neuropsychological and social adaptive outcome in early adult life.

    Science.gov (United States)

    Hagberg, Bibbi S; Nydén, Agneta; Cederlund, Mats; Gillberg, Christopher

    2013-12-15

    Co-existence of Asperger syndrome (AS) and non-verbal learning disability (NLD) has been proposed based on the observation that people with AS tend to have significantly higher verbal than performance IQ (VIQ > PIQ by ≥ 15 points), one of the core features of NLD. In the present study we examined neuropsychological and social adaptive profiles with "non-verbal learning problems" associated with NLD in a group of individuals with AS followed from childhood into early adult life. The group was divided into three subgroups: (i) persistent NLD (P-NLD), i.e. NLD (VIQ > PIQ) both in childhood and early adulthood occasions, (ii) childhood NLD (CO-NLD), i.e. NLD (VIQ > PIQ) only at original diagnosis, or (iii) No NLD (VIQ > PIQ) ever (NO-NLD). All three subgroups were followed prospectively from childhood into adolescence and young adult life. One in four to one in five of the whole group of males with AS had P-NLD. The P-NLD subgroup had poorer neuropsychological outcome in early adult life than did those with CO-NLD and those with NO-NLD. There were no unequivocal markers in early childhood that predicted subgroup status in early adult life, but early motor delay and a history of early speech-language problems tended to be associated with P-NLD.

  20. Realities of weather extremes on daily life in urban India - How quantified impacts infer sensible adaptation options

    Science.gov (United States)

    Reckien, D.

    2012-12-01

    Emerging and developing economies are currently undergoing one of the profoundest socio-spatial transitions in their history, with strong urbanization and weather extremes bringing about changes in the economy, forms of living and living conditions, but also increasing risks and altered social divides. The impacts of heat waves and strong rain events are therefore differently perceived among urban residents. Addressing the social differences of climate change impacts1 and expanding targeted adaptation options have emerged as urgent policy priorities, particularly for developing and emerging economies2. This paper discusses the perceived impacts of weather-related extreme events on different social groups in New Delhi and Hyderabad, India. Using network statistics and scenario analysis on Fuzzy Cognitive Maps (FCMs) as part of a vulnerability analysis, the investigation provides quantitative and qualitative measures to compare impacts and adaptation strategies for different social groups. Impacts of rain events are stronger than those of heat in both cities and affect the lower income classes particularly. Interestingly, the scenario analysis (comparing altered networks in which the alteration represents a possible adaptation measure) shows that investments in the water infrastructure would be most meaningful and more effective than investments in, e.g., the traffic infrastructure, despite the stronger burden from traffic disruptions and the resulting concentration of planning and policy on traffic ease and investments. The method of Fuzzy Cognitive Mapping offers a link between perception and modeling, and the possibility to aggregate and analyze the views of a large number of stakeholders. Our research has shown that planners and politicians often know about many of the problems, but are often overwhelmed by the problems in their respective cities and look for a prioritization of adaptation options. FCM provides this need and identifies priority adaptation options

  1. A cellular automaton model adapted to sandboxes to simulate the transport of solutes

    Science.gov (United States)

    Lora, Boris; Donado, Leonardo; Castro, Eduardo; Bayuelo, Alfredo

    2016-04-01

    The increasingly use of groundwater sources for human consumption and the growth of the levels of these hydric sources contamination make imperative to reach a deeper understanding how the contaminants are transported by the water, in particular through a heterogeneous porous medium. Accordingly, the present research aims to design a model, which simulates the transport of solutes through a heterogeneous porous medium, using cellular automata. Cellular automata (CA) are a class of spatially (pixels) and temporally discrete mathematical systems characterized by local interaction (neighborhoods). The pixel size and the CA neighborhood were determined in order to reproduce accurately the solute behavior (Ilachinski, 2001). For the design and corresponding validation of the CA model were developed different conservative tracer tests using a sandbox packed heterogeneously with a coarse sand (size # 20 grain diameter 0,85 to 0,6 mm) and clay. We use Uranine and a saline solution with NaCl as a tracer which were measured taking snapshots each 20 seconds. A calibration curve (pixel intensity Vs Concentration) was used to obtain concentration maps. The sandbox was constructed of acrylic (caliber 0,8 cms) with 70 x 45 x 4 cms of dimensions. The "sandbox" had a grid of 35 transversal holes with a diameter of 4 mm each and an uniform separation from one to another of 10 cms. To validate the CA-model it was used a metric consisting in rating the number of correctly predicted pixels over the total per image throughout the entire test run. The CA-model shows that calibrations of pixels and neighborhoods allow reaching results over the 60 % of correctly predictions usually. This makes possible to think that the application of the CA- model could be useful in further researches regarding the transport of contaminants in hydrogeology.

  2. Validity and Reliability of the Dutch Adaptation of the Psoriatic Arthritis Quality of Life (PsAQoL) Questionnaire

    OpenAIRE

    Wink, Freke; Arends, Suzanne; McKenna, Stephen P; Houtman, Pieternella M.; Brouwer, Elisabeth; Spoorenberg, Anneke

    2013-01-01

    Objective The Psoriatic Arthritis Quality of Life (PsAQoL) questionnaire is a disease- specific instrument developed to measure quality of life (QoL) in patients with psoriatic arthritis (PsA). The aim of this study was to translate the measure into Dutch and to determine its psychometric properties. Method Translation of the original English PsAQoL into Dutch was performed by bilingual and lay panel. Ten field-test interviews with PsA patients were performed to assess face and content validi...

  3. Effect of simulation on knowledge of advanced cardiac life support, knowledge retention, and confidence of nursing students in Jordan.

    Science.gov (United States)

    Tawalbeh, Loai I; Tubaishat, Ahmad

    2014-01-01

    This study examined the effect of simulation on nursing students' knowledge of advanced cardiac life support (ACLS), knowledge retention, and confidence in applying ACLS skills. An experimental, randomized controlled (pretest-posttest) design was used. The experimental group (n = 40) attended an ACLS simulation scenario, a 4-hour PowerPoint presentation, and demonstration on a static manikin, whereas the control group (n = 42) attended the PowerPoint presentation and a demonstration only. A paired t test indicated that posttest mean knowledge of ACLS and confidence was higher in both groups. The experimental group showed higher knowledge of ACLS and higher confidence in applying ACLS, compared with the control group. Traditional training involving PowerPoint presentation and demonstration on a static manikin is an effective teaching strategy; however, simulation is significantly more effective than traditional training in helping to improve nursing students' knowledge acquisition, knowledge retention, and confidence about ACLS.

  4. A low-numerical dissipation, patch-based adaptive-mesh-refinement method for large-eddy simulation of compressible flows

    Science.gov (United States)

    Pantano, C.; Deiterding, R.; Hill, D. J.; Pullin, D. I.

    2006-09-01

    This paper describes a hybrid finite-difference method for the large-eddy simulation of compressible flows with low-numerical dissipation and structured adaptive mesh refinement (SAMR). A conservative flux-based approach is described with an explicit centered scheme used in turbulent flow regions while a weighted essentially non-oscillatory (WENO) scheme is employed to capture shocks. Three-dimensional numerical simulations of a Richtmyer-Meshkov instability are presented.

  5. Adaptation and validation of the Osteoarthritis Knee and Hip Quality of Life (OAKHQOL) questionnaire for use in patients with osteoarthritis in Spain.

    Science.gov (United States)

    Gonzalez Sáenz de Tejada, Marta; Escobar, Antonio; Herdman, Michael; Herrera, Carmen; García, Lidia; Sarasqueta, Cristina

    2011-12-01

    This study aims to adapt and validate the Spanish version of the Osteoarthritis Knee and Hip Quality of Life (OAKHQOL) questionnaire. The OAKHQOL was adapted into Spanish using a forward-backward translation methodology. The Spanish version was then validated in a prospective, mixed-design study of 759 patients with hip or knee osteoarthritis (OA). Patients completed the OAKHQOL, Short Form 36 (SF-36), Western Ontario and McMaster Universities Osteoarthritis Index, and the EQ-5D. The internal consistency was evaluated using Cronbach's alpha. Convergent validity was assessed by examining correlations between the OAKHQOL and other patient-reported instruments; known groups' validity was assessed by determining the capacity of the OAKHQOL to discriminate between patients with different levels of disease severity measured using the Lequesne Index. Test-retest reliability was evaluated by calculating the intraclass correlation coefficient (ICC) for all OAKHQOL domains in 409 stable patients with OA. Responsiveness was evaluated by calculating effect sizes among 129 patients undergoing hip or knee replacement. Cronbach's alpha for the five domains of the OAKHQOL ranged from 0.60 to 0.93 while ICCs ranged from 0.75 to 0.81 for all domains except the two social domains. Statistically significant differences (p social support". The instrument showed convergent validity among hypothesized domains (p Spanish version OAKHQOL questionnaire was a valid instrument to measure health-related quality of life in patients with OA of the lower limb. PMID:21947701

  6. Dynamic self-adaptive ANP algorithm and its application to electric field simulation of aluminum reduction cell

    Institute of Scientific and Technical Information of China (English)

    王雅琳; 陈冬冬; 陈晓方; 蔡国民; 阳春华

    2015-01-01

    Region partition (RP) is the key technique to the finite element parallel computing (FEPC), and its performance has a decisive influence on the entire process of analysis and computation. The performance evaluation index of RP method for the three-dimensional finite element model (FEM) has been given. By taking the electric field of aluminum reduction cell (ARC) as the research object, the performance of two classical RP methods, which are Al-NASRA and NGUYEN partition (ANP) algorithm and the multi-level partition (MLP) method, has been analyzed and compared. The comparison results indicate a sound performance of ANP algorithm, but to large-scale models, the computing time of ANP algorithm increases notably. This is because the ANP algorithm determines only one node based on the minimum weight and just adds the elements connected to the node into the sub-region during each iteration. To obtain the satisfied speed and the precision, an improved dynamic self-adaptive ANP (DSA-ANP) algorithm has been proposed. With consideration of model scale, complexity and sub-RP stage, the improved algorithm adaptively determines the number of nodes and selects those nodes with small enough weight, and then dynamically adds these connected elements. The proposed algorithm has been applied to the finite element analysis (FEA) of the electric field simulation of ARC. Compared with the traditional ANP algorithm, the computational efficiency of the proposed algorithm has been shortened approximately from 260 s to 13 s. This proves the superiority of the improved algorithm on computing time performance.

  7. Working as simulated patient has effects on real patient life – Preliminary insights from a qualitative study

    Directory of Open Access Journals (Sweden)

    Simmenroth-Nayda, Anne

    2016-05-01

    Full Text Available Background: Persons who simulate patients during medical education understand the routines and the underlying script of medical consultations better. We aimed to explore how simulated patients (SPs integrated this new understanding into their daily life, how this work affected their private life as patients, and what we can learn from these changes for concepts of empowerment.Design, setting, and participants: A qualitative interview study. All SPs of Göttingen medical school who had been working longer than three semesters (n=14 were invited and agreed to take part in an open interview about their daily experience with real doctors. Documentary method was used to identify the main issues. Several cases were chosen according to maximum contrast and analysed by in-depth analysis to provide vivid examples of how simulations may affect the real life of the SPs as patients.Results: Our analysis revealed three main changes in the behaviour of SPs as real patients. They were more attentive, had a better understanding of the circumstances under which doctors work, and acted more self-confidently. From the selected cases it became apparent that working as a SP may lead to a constant and significant decrease of fear of hospitals and medical procedures or, in other cases, may enable the SPs to develop new abilities for giving feedback, questioning procedures, and explanations for real doctors.Conclusion: working as a simulated patient seems to be well-suited to understand own progression of diseases, to increase self-responsibility and to a confident attitude as patient.

  8. A high-order adaptive Cartesian cut-cell method for simulation of compressible viscous flow over immersed bodies

    Science.gov (United States)

    Muralidharan, Balaji; Menon, Suresh

    2016-09-01

    A new adaptive finite volume conservative cut-cell method that is third-order accurate for simulation of compressible viscous flows is presented. A high-order reconstruction approach using cell centered piecewise polynomial approximation of flow quantities, developed in the past for body-fitted grids, is now extended to the Cartesian based cut-cell method. It is shown that the presence of cut-cells of very low volume results in numerical oscillations in the flow solution near the embedded boundaries when standard small cell treatment techniques are employed. A novel cell clustering approach for polynomial reconstruction in the vicinity of the small cells is proposed and is shown to achieve smooth representation of flow field quantities and their derivatives on immersed interfaces. It is further shown through numerical examples that the proposed clustering method achieves the design order of accuracy and is fairly insensitive to the cluster size. Results are presented for canonical flow past a single cylinder and a sphere at different flow Reynolds numbers to verify the accuracy of the scheme. Investigations are then performed for flow over two staggered cylinders and the results are compared with prior data for the same configuration. All the simulations are carried out with both quadratic and cubic reconstruction, and the results indicate a clear improvement with the cubic reconstruction. The new cut-cell approach with cell clustering is able to predict accurate results even at relatively low resolutions. The ability of the high-order cut-cell method in handling sharp geometrical corners and narrow gaps is also demonstrated using various examples. Finally, three-dimensional flow interactions between a pair of spheres in cross flow is investigated using the proposed cut-cell scheme. The results are shown to be in excellent agreement with past studies, which employed body-fitted grids for studying this complex case.

  9. A New Predictive Model Based on the ABC Optimized Multivariate Adaptive Regression Splines Approach for Predicting the Remaining Useful Life in Aircraft Engines

    Directory of Open Access Journals (Sweden)

    Paulino José García Nieto

    2016-05-01

    Full Text Available Remaining useful life (RUL estimation is considered as one of the most central points in the prognostics and health management (PHM. The present paper describes a nonlinear hybrid ABC–MARS-based model for the prediction of the remaining useful life of aircraft engines. Indeed, it is well-known that an accurate RUL estimation allows failure prevention in a more controllable way so that the effective maintenance can be carried out in appropriate time to correct impending faults. The proposed hybrid model combines multivariate adaptive regression splines (MARS, which have been successfully adopted for regression problems, with the artificial bee colony (ABC technique. This optimization technique involves parameter setting in the MARS training procedure, which significantly influences the regression accuracy. However, its use in reliability applications has not yet been widely explored. Bearing this in mind, remaining useful life values have been predicted here by using the hybrid ABC–MARS-based model from the remaining measured parameters (input variables for aircraft engines with success. A correlation coefficient equal to 0.92 was obtained when this hybrid ABC–MARS-based model was applied to experimental data. The agreement of this model with experimental data confirmed its good performance. The main advantage of this predictive model is that it does not require information about the previous operation states of the aircraft engine.

  10. Adaptable Web Modules to Stimulate Active Learning in Engineering Hydrology using Data and Model Simulations of Three Regional Hydrologic Systems

    Science.gov (United States)

    Habib, E. H.; Tarboton, D. G.; Lall, U.; Bodin, M.; Rahill-Marier, B.; Chimmula, S.; Meselhe, E. A.; Ali, A.; Williams, D.; Ma, Y.

    2013-12-01

    The hydrologic community has long recognized the need for broad reform in hydrologic education. A paradigm shift is critically sought in undergraduate hydrology and water resource education by adopting context-rich, student-centered, and active learning strategies. Hydrologists currently deal with intricate issues rooted in complex natural ecosystems containing a multitude of interconnected processes. Advances in the multi-disciplinary field include observational settings such as Critical Zone and Water, Sustainability and Climate Observatories, Hydrologic Information Systems, instrumentation and modeling methods. These research advances theory and practices call for similar efforts and improvements in hydrologic education. The typical, text-book based approach in hydrologic education has focused on specific applications and/or unit processes associated with the hydrologic cycle with idealizations, rather than the contextual relations in the physical processes and the spatial and temporal dynamics connecting climate and ecosystems. An appreciation of the natural variability of these processes will lead to graduates with the ability to develop independent learning skills and understanding. This appreciation cannot be gained in curricula where field components such as observational and experimental data are deficient. These types of data are also critical when using simulation models to create environments that support this type of learning. Additional sources of observations in conjunction with models and field data are key to students understanding of the challenges associated with using models to represent such complex systems. Recent advances in scientific visualization and web-based technologies provide new opportunities for the development of active learning techniques utilizing ongoing research. The overall goal of the current study is to develop visual, case-based, data and simulation driven learning experiences to instructors and students through a web

  11. Non-iterative adaptive time-stepping scheme with temporal truncation error control for simulating variable-density flow

    Science.gov (United States)

    Hirthe, Eugenia M.; Graf, Thomas

    2012-12-01

    The automatic non-iterative second-order time-stepping scheme based on the temporal truncation error proposed by Kavetski et al. [Kavetski D, Binning P, Sloan SW. Non-iterative time-stepping schemes with adaptive truncation error control for the solution of Richards equation. Water Resour Res 2002;38(10):1211, http://dx.doi.org/10.1029/2001WR000720.] is implemented into the code of the HydroGeoSphere model. This time-stepping scheme is applied for the first time to the low-Rayleigh-number thermal Elder problem of free convection in porous media [van Reeuwijk M, Mathias SA, Simmons CT, Ward JD. Insights from a pseudospectral approach to the Elder problem. Water Resour Res 2009;45:W04416, http://dx.doi.org/10.1029/2008WR007421.], and to the solutal [Shikaze SG, Sudicky EA, Schwartz FW. Density-dependent solute transport in discretely-fractured geological media: is prediction possible? J Contam Hydrol 1998;34:273-91] problem of free convection in fractured-porous media. Numerical simulations demonstrate that the proposed scheme efficiently limits the temporal truncation error to a user-defined tolerance by controlling the time-step size. The non-iterative second-order time-stepping scheme can be applied to (i) thermal and solutal variable-density flow problems, (ii) linear and non-linear density functions, and (iii) problems including porous and fractured-porous media.

  12. Simulated Real-Life Experiences Using Classified Ads in the Classroom.

    Science.gov (United States)

    Hechler, Ellen

    This guide contains activities to help teachers give middle school students experience in practical life skills. Techniques include role playing and using classified advertisements from newspapers. The five lessons include teacher tips on conducting the activities. Lessons contain objectives, materials needed, discussion, and suggested dialogue.…

  13. Lifestyles, spatial configurations and quality of life in daily travel: an explorative simulation study

    NARCIS (Netherlands)

    J. Ritsema van Eck; G. Burghouwt; M. Dijst

    2005-01-01

    The aim of this study is to compare a number of local spatial configurations of land use and transport facilities in a Dutch new town to address the question what impact these configurations have on the quality of life of different population categories. The results suggest that concentrating servic

  14. Experiencing the Product Life Cycle Management Highs and Lows through Dramatic Simulation

    Science.gov (United States)

    Pearce, Glenn; Jackson, John

    2009-01-01

    Product life cycle (PLC) stages and diagrams are briefly and dispassionately covered in the standard marketing textbook format with little attention to the social-psychological experiences of those actually participating. This qualitative study used process drama as a teaching tool and a research instrument to probe the PLC phenomenon in a…

  15. Simulation and Assessment of Whole Life-Cycle Carbon Emission Flows from Different Residential Structures

    Directory of Open Access Journals (Sweden)

    Rikun Wen

    2016-08-01

    Full Text Available To explore the differences in carbon emissions over the whole life-cycle of different building structures, the published calculated carbon emissions from residential buildings in China and abroad were normalized. Embodied carbon emission flows, operations stage carbon emission flows, demolition and reclamation stage carbon emission flows and total life-cycle carbon emission flows from concrete, steel, and wood structures were obtained. This study is based on the theory of the social cost of carbon, with an adequately demonstrated social cost of carbon and social discount rate. Taking into consideration both static and dynamic situations and using a social discount rate of 3.5%, the total life-cycle carbon emission flows, absolute carbon emission and building carbon costs were calculated and assessed. The results indicated that concrete structures had the highest embodied carbon emission flows and negative carbon emission flows in the waste and reclamation stage. Wood structures that started the life-cycle with stored carbon had the lowest carbon emission flows in the operations stage and relatively high negative carbon emission flows in the reclamation stage. Wood structures present the smallest carbon footprints for residential buildings.

  16. 大学生适应性与生活满意度的关系:生命意义的中介作用%On Relationship Between Adaptation and Life Satisfaction of College Students:Meaning in Life as a Mediator

    Institute of Scientific and Technical Information of China (English)

    胡天强; 龚玲; 张茂杨; 王鑫强

    2014-01-01

    为探讨大学生适应性、生命意义和生活满意度三者之间的关系,采用问卷法对268名大学生进行调查研究。结果发现:①适应性、生命意义和生活满意度三者之间呈显著正相关;②适应性除直接影响生活满意度外,还通过生命意义间接影响生活满意度,生命意义在适应性与生活满意度之间起部分中介作用。%To explore the relationship between adaptation and life satisfaction,and also the mediating effects of meaning in life,268 college students have been selected to fill in questionnaires.The results indi-cate that ① there are significantly positive relations among adaptation,meaning in life and life satisfaction;② besides directly influencing life satisfaction,adaptation also contributed to life satisfaction through meaning in life.These findings suggest that meaning in life is a mediator between adaptation and life satis-faction.

  17. Local adaptation at the transcriptome level in brown trout: Evidence from early life history temperature genomic reaction norms

    DEFF Research Database (Denmark)

    Meier, Kristian; Hansen, Michael Møller; Normandeau, Eric;

    2014-01-01

    . These included genes involved in immune- and stress response. We observed less plasticity in the resident as compared to the anadromous populations, possibly reflecting that the degree of environmental heterogeneity encountered by individuals throughout their life cycle will select for variable level...... C) representing conditions encountered in the local environments. Global gene expression for fry at the stage of first feeding was analysed using a 32k cDNA microarray. The results revealed differences in gene expression between populations and temperatures and population × temperature interactions...

  18. Field Simulation of a Drilling Mission to Mars to Search for Subsurface Life

    Science.gov (United States)

    Stoker, C. R.; Lemke, L. G.; Cannon, H.; Glass, B.; Dunagan, S.; Zavaleta, J.; Miller, D.; Gomez-Elvira, J.

    2005-01-01

    The discovery of near surface ground ice by the Mars Odyssey mission and the abundant evidence for recent Gulley features observed by the Mars Global Surveyor mission support longstanding theoretical arguments for subsurface liquid water on Mars. Thus, implementing the Mars program goal to search for life points to drilling on Mars to reach liquid water, collecting samples and analyzing them with instrumentation to detect in situ organisms and biomarker compounds. Searching for life in the subsurface of Mars will require drilling, sample extraction and handling, and new technologies to find and identify biomarker compounds and search for living organisms. In spite of its obvious advantages, robotic drilling for Mars exploration is in its technological infancy and has yet to be demonstrated in even a terrestrial field environment.

  19. An Electric taxi fleet charging system using second life electric car batteries simulation and economical approach

    OpenAIRE

    Canals Casals, Lluc; Amante García, Beatriz

    2013-01-01

    The industrial car manufacturers see in the high battery price an im-portant obstacle for an electric vehicle mass selling, thus mass production. There-fore, in order to find some cost relieves and better selling opportunities, they look and push forward to find profitable second battery uses. This study presents a sim-ulation and an economical approach for an electric taxi fleet charging system, us-ing these “old” electric car batteries, implemented in the city of Barcelona. The simulation w...

  20. Adaptation of the MacNew quality of life questionnaire after myocardial infarction in an Iranian population

    Directory of Open Access Journals (Sweden)

    Oldridge Neil B

    2003-07-01

    Full Text Available Abstract Background Health-related quality of life (HRQL assessment is an important measure of the impact of a wide range of disease process on an individual. To date, no HRQL tool has been evaluated in an Iranian population with cardiovascular disorders, specifically myocardial infarction, a major cause of mortality and morbidity. The MacNew Heart Disease Health-related Quality of Life instrument is a disease-specific HRQL questionnaire with satisfactory validity and reliability when applied cross-culturally. Method A Persian version of MacNew was prepared by both forward and backward translation by bilinguals after which a feasibility test was performed. Consecutive patients (n = 51 admitted to a coronary care unit with acute myocardial infarction were recruited for measurement of their HRQL with retest one month after discharge in the follow-up clinic. Principal components analysis, intra-class correlation reliability, internal consistency, and test-retest reliability were assessed. Results Trivial rates of missing data confirmed the acceptability of the tool. Principal component analysis revealed that the three domains, emotional, social and physical, performed as well as in the original studies. Internal consistency was high and comparable to other studies, ranging from 0.92 for the emotional and physical domains, to 0.94 for the social domain, and to 0.95 for the Global score. Domain means of 5, 5.3 and 4.9 for emotional, physical and social respectively indicate that our Iranian population has similar emotional and physical but worse social HRQL scores. Test-retest analysis showed significant correlation in emotional and physical domains (P Conclusion The Persian version of the MacNew questionnaire is comparable to the English version. It has high internal consistency and reasonable reproducibility, making it an appropriate specific quality of life tool for population-based studies and clinical practice in Iran in patients who have

  1. Explaining bathymetric diversity patterns in marine benthic invertebrates and demersal fishes: physiological contributions to adaptation of life at depth.

    Science.gov (United States)

    Brown, Alastair; Thatje, Sven

    2014-05-01

    Bathymetric biodiversity patterns of marine benthic invertebrates and demersal fishes have been identified in the extant fauna of the deep continental margins. Depth zonation is widespread and evident through a transition between shelf and slope fauna from the shelf break to 1000 m, and a transition between slope and abyssal fauna from 2000 to 3000 m; these transitions are characterised by high species turnover. A unimodal pattern of diversity with depth peaks between 1000 and 3000 m, despite the relatively low area represented by these depths. Zonation is thought to result from the colonisation of the deep sea by shallow-water organisms following multiple mass extinction events throughout the Phanerozoic. The effects of low temperature and high pressure act across hierarchical levels of biological organisation and appear sufficient to limit the distributions of such shallow-water species. Hydrostatic pressures of bathyal depths have consistently been identified experimentally as the maximum tolerated by shallow-water and upper bathyal benthic invertebrates at in situ temperatures, and adaptation appears required for passage to deeper water in both benthic invertebrates and demersal fishes. Together, this suggests that a hyperbaric and thermal physiological bottleneck at bathyal depths contributes to bathymetric zonation. The peak of the unimodal diversity-depth pattern typically occurs at these depths even though the area represented by these depths is relatively low. Although it is recognised that, over long evolutionary time scales, shallow-water diversity patterns are driven by speciation, little consideration has been given to the potential implications for species distribution patterns with depth. Molecular and morphological evidence indicates that cool bathyal waters are the primary site of adaptive radiation in the deep sea, and we hypothesise that bathymetric variation in speciation rates could drive the unimodal diversity-depth pattern over time. Thermal

  2. Life history responses to irradiance at the early seedling stage of Picea omorika (Pančić) Purkyňe: adaptiveness and evolutionary limits

    Science.gov (United States)

    Tucić, Branka; Pemac, Danijela; Dučić, Jelena

    2005-05-01

    A multivariate selection analysis has been implemented for testing the adaptiveness of life history plasticity to irradiance during the seedling establishment in Picea omorika plants raised in a growth-room. Siblings of a synthetic population comprising 21 families from six natural populations were exposed to contrasting light levels to explore variation in phenotypic expression of three seedling traits: days from germination to cotyledon opening (DGTOC), days from cotyledon opening to epicotyl appearance (DCTOE), and epicotyl length at 6 weeks (EPL6). Ambient light conditions significantly affected DCTOE and EPL6, but not DGTOC. Phenotypic selection analysis revealed that DGTOC was under negative directional selection in both radiation environments, suggesting that canalization of DGTOC was promoted across different light conditions, as well as that the observed pattern of canalization might be regarded as adaptive. DCTOE was also found to be under negative directional selection in both light treatments, but the plastic responses of this trait were opposite to the values favoured by selection within environments. Since there was evidence for selection against plasticity in DCTOE, the pattern of plastic responses in DCTOE to variation in light conditions could be diagnosed as maladaptive. Multiple regression analysis revealed a cost of canalization in DGTOC regardless of light environment, as well as a cost of plasticity in DCTOE under high light intensity. All genetic correlations across light environments were significantly different from unity, indicating the existence of heritable variation for plasticity in these traits. However, since DGTOC and DCTOE were involved in a genetic trade-off with respect to both trait mean and plasticity, these early life histories would never reach their optimal values across radiation environments.

  3. A locally p-adaptive approach for Large Eddy Simulation of compressible flows in a DG framework

    CERN Document Server

    Tugnoli, Matteo; Bonaventura, Luca; Restelli, Marco

    2016-01-01

    We investigate the possibility of reducing the computational burden of LES models by employing local polynomial degree adaptivity in the framework of a high order DG method. A novel degree adaptation technique especially featured to be effective for LES applications is proposed and its effectiveness is compared to that of other criteria already employed in the literature. The resulting locally adaptive approach allows to achieve significant reductions in computational cost of representative LES computations.

  4. Impact of Chisan (ADAPT-232) on the quality-of-life and its efficacy as an adjuvant in the treatment of acute non-specific pneumonia.

    Science.gov (United States)

    Narimanian, M; Badalyan, M; Panosyan, V; Gabrielyan, E; Panossian, A; Wikman, G; Wagner, H

    2005-11-01

    A double-blind, placebo-controlled, randomized (simple randomisation), pilot (phase III) study of Chisan, (ADAPT-232; a standardised fixed combination of extracts of Rhodiola rosea L., Schisandra chinensis Turcz. Baill., and Eleutherococcus senticosus Maxim) was carried out on two parallel groups of patients suffering from acute nonspecific pneumonia. Sixty patients (males and females; 18-65 years old) received a standard treatment with cephazoline, bromhexine, and theophylline: in addition, one group of 30 patients was given Chisan mixture, whilst the second group of 30 patients received a placebo, each medication being taken twice daily from the beginning of the study for 10-15 days. The primary outcome measurements were the duration of antibiotic therapy associated with the clinical manifestations of the acute phase of the disease, together with an evaluation of mental performance in a psychometric test and the self-evaluation of quality-of-life (QOL) (WHOQOL-Bref questionnaires) before treatment and on the first and fifth days after clinical convalescence. The mean duration of treatment with antibiotics required to bring about recovery from the acute phase of the disease was 2 days shorter in patients treated with Chisan compared with those in the placebo group. With respect to all QOL domains (physical, psychological, social and ecological), patients in the Chisan group scored higher at the beginning of the rehabilitation period, and significantly higher on the fifth day after clinical convalescence, than patients in the control group. Clearly, adjuvant therapy with ADAPT-232 has a positive effect on the recovery of patients by decreasing the duration of the acute phase of the illness, by increasing mental performance of patients in the rehabilitation period, and by improving their QOL. Both the clinical and laboratory results of the present study suggest that Chisan (ADAPT-232) can be recommended in the standard treatment of patients with acute non

  5. Adaptive planning strategy for high dose rate prostate brachytherapy—a simulation study on needle positioning errors.

    Science.gov (United States)

    Borot de Battisti, M; Denis de Senneville, B; Maenhout, M; Hautvast, G; Binnekamp, D; Lagendijk, J J W; van Vulpen, M; Moerland, M A

    2016-03-01

    The development of magnetic resonance (MR) guided high dose rate (HDR) brachytherapy for prostate cancer has gained increasing interest for delivering a high tumor dose safely in a single fraction. To support needle placement in the limited workspace inside the closed-bore MRI, a single-needle MR-compatible robot is currently under development at the University Medical Center Utrecht (UMCU). This robotic device taps the needle in a divergent way from a single rotation point into the prostate. With this setup, it is warranted to deliver the irradiation dose by successive insertions of the needle. Although robot-assisted needle placement is expected to be more accurate than manual template-guided insertion, needle positioning errors may occur and are likely to modify the pre-planned dose distribution.In this paper, we propose a dose plan adaptation strategy for HDR prostate brachytherapy with feedback on the needle position: a dose plan is made at the beginning of the interventional procedure and updated after each needle insertion in order to compensate for possible needle positioning errors. The introduced procedure can be used with the single needle MR-compatible robot developed at the UMCU. The proposed feedback strategy was tested by simulating complete HDR procedures with and without feedback on eight patients with different numbers of needle insertions (varying from 4 to 12). In of the cases tested, the number of clinically acceptable plans obtained at the end of the procedure was larger with feedback compared to the situation without feedback. Furthermore, the computation time of the feedback between each insertion was below 100 s which makes it eligible for intra-operative use.

  6. Simulation of an Economic Policy on Second Life Using a Conjunctural Analysis Approach

    Directory of Open Access Journals (Sweden)

    Yrina JANVIER

    2007-01-01

    Full Text Available This paper intends to define an economic policy that does notcompromise the coordination between the 4 main sectors of an economy: the real sector, the public sector, the exterior sector and the monetary sector. The subject is Second Life (SL a totally virtual world that is starting to occupy a great economicplace especially with e-commerce. For doing so, some data are arbitrarily chosen as done and projections are made from them. Data are expressed in billion of Linden dollars.

  7. Skeletal muscle cells possess a 'memory' of acute early life TNF-α exposure: role of epigenetic adaptation.

    Science.gov (United States)

    Sharples, Adam P; Polydorou, Ioanna; Hughes, David C; Owens, Daniel J; Hughes, Thomas M; Stewart, Claire E

    2016-06-01

    Sufficient quantity and quality of skeletal muscle is required to maintain lifespan and healthspan into older age. The concept of skeletal muscle programming/memory has been suggested to contribute to accelerated muscle decline in the elderly in association with early life stress such as fetal malnutrition. Further, muscle cells in vitro appear to remember the in vivo environments from which they are derived (e.g. cancer, obesity, type II diabetes, physical inactivity and nutrient restriction). Tumour-necrosis factor alpha (TNF-α) is a pleiotropic cytokine that is chronically elevated in sarcopenia and cancer cachexia. Higher TNF-α levels are strongly correlated with muscle loss, reduced strength and therefore morbidity and earlier mortality. We have extensively shown that TNF-α impairs regenerative capacity in mouse and human muscle derived stem cells [Meadows et al. (J Cell Physiol 183(3):330-337, 2000); Foulstone et al. (J Cell Physiol 189(2):207-215, 2001); Foulstone et al. (Exp Cell Res 294(1):223-235, 2004); Stewart et al. (J Cell Physiol 198(2):237-247, 2004); Al-Shanti et al. (Growth factors (Chur, Switzerland) 26(2):61-73, 2008); Saini et al. (Growth factors (Chur, Switzerland) 26(5):239-253, 2008); Sharples et al. (J Cell Physiol 225(1):240-250, 2010)]. We have also recently established an epigenetically mediated mechanism (SIRT1-histone deacetylase) regulating survival of myoblasts in the presence of TNF-α [Saini et al. (Exp Physiol 97(3):400-418, 2012)]. We therefore wished to extend this work in relation to muscle memory of catabolic stimuli and the potential underlying epigenetic modulation of muscle loss. To enable this aim; C2C12 myoblasts were cultured in the absence or presence of early TNF-α (early proliferative lifespan) followed by 30 population doublings in the absence of TNF-α, prior to the induction of differentiation in low serum media (LSM) in the absence or presence of late TNF-α (late proliferative lifespan). The cells that

  8. Skeletal muscle cells possess a 'memory' of acute early life TNF-α exposure: role of epigenetic adaptation.

    Science.gov (United States)

    Sharples, Adam P; Polydorou, Ioanna; Hughes, David C; Owens, Daniel J; Hughes, Thomas M; Stewart, Claire E

    2016-06-01

    Sufficient quantity and quality of skeletal muscle is required to maintain lifespan and healthspan into older age. The concept of skeletal muscle programming/memory has been suggested to contribute to accelerated muscle decline in the elderly in association with early life stress such as fetal malnutrition. Further, muscle cells in vitro appear to remember the in vivo environments from which they are derived (e.g. cancer, obesity, type II diabetes, physical inactivity and nutrient restriction). Tumour-necrosis factor alpha (TNF-α) is a pleiotropic cytokine that is chronically elevated in sarcopenia and cancer cachexia. Higher TNF-α levels are strongly correlated with muscle loss, reduced strength and therefore morbidity and earlier mortality. We have extensively shown that TNF-α impairs regenerative capacity in mouse and human muscle derived stem cells [Meadows et al. (J Cell Physiol 183(3):330-337, 2000); Foulstone et al. (J Cell Physiol 189(2):207-215, 2001); Foulstone et al. (Exp Cell Res 294(1):223-235, 2004); Stewart et al. (J Cell Physiol 198(2):237-247, 2004); Al-Shanti et al. (Growth factors (Chur, Switzerland) 26(2):61-73, 2008); Saini et al. (Growth factors (Chur, Switzerland) 26(5):239-253, 2008); Sharples et al. (J Cell Physiol 225(1):240-250, 2010)]. We have also recently established an epigenetically mediated mechanism (SIRT1-histone deacetylase) regulating survival of myoblasts in the presence of TNF-α [Saini et al. (Exp Physiol 97(3):400-418, 2012)]. We therefore wished to extend this work in relation to muscle memory of catabolic stimuli and the potential underlying epigenetic modulation of muscle loss. To enable this aim; C2C12 myoblasts were cultured in the absence or presence of early TNF-α (early proliferative lifespan) followed by 30 population doublings in the absence of TNF-α, prior to the induction of differentiation in low serum media (LSM) in the absence or presence of late TNF-α (late proliferative lifespan). The cells that

  9. Cross-cultural adaptation of the German version of the Quality of Life in Alzheimer's Disease scale - Nursing Home version (QoL-AD NH).

    Science.gov (United States)

    Dichter, Martin Nikolaus; Wolschon, Eva-Maria; Meyer, Gabriele; Köpke, Sascha

    2016-08-01

    Dementia is a chronic and currently incurable syndrome. Therefore, quality of life (QoL) is a major goal when caring for people with dementia (Gibson et al., 2010) and a major outcome in dementia research (Moniz-Cook et al., 2008). The measurement of QoL, especially proxy-rating, is challenging because of the proxy-perspective (Pickard and Knight, 2005), reliability (Dichter et al., 2016), validity (O'Rourke et al., 2015), and responsiveness (Perales et al., 2013). Probably due to these challenges, it has not been possible to show positive effects for QoL in almost all non-pharmacological interventions for people with dementia (Cooper et al., 2012). One recommended (Moniz-Cook et al., 2008) and frequently used instrument is the Quality of Life in Alzheimer's Disease scale (QoL-AD), which was originally developed in the US for community-dwelling people with dementia. The QoL-AD consists of 13 items based on a 4-point Likert scale ranging from "1"=poor to "4"=excellent (Logsdon et al., 1999). The original instrument has been adapted for people living in nursing homes (NH) by Edelmann et al. (2005). PMID:26863077

  10. Artificial Life:Visual Model with Simulation of a Plant Pet

    Institute of Scientific and Technical Information of China (English)

    JI Chen; QI Shen

    2004-01-01

    This paper introduces an L-system model, which simulates a plant pet. The plant, named Wilson, is able to respond to the change of its virtual environment and to user's behaviors. However it does not speak or move. What users can see are only the changes of its appearance. The connection between the plant's appearance and external inputs is implemented with some parameters embedded in the L-system.

  11. Is diet flexibility an adaptive life trait for relictual and peri-urban populations of the endangered primate Macaca sylvanus?

    Science.gov (United States)

    Maibeche, Yasmina; Moali, Aissa; Yahi, Nassima; Menard, Nelly

    2015-01-01

    Habitat loss, fragmentation and urban expansion may drive some species to marginal habitats while others succeed in exploiting urban areas. Species that show dietary flexibility are more able to take advantage of human activities to supplement their diet with anthropogenically abundant and accessible resources. The Barbary macaque (Macaca sylvanus) is an endangered species due to the loss of its habitat, and human pressure. The population of Gouraya National Park (Algeria) lives in a relictual habitat that constitutes about 0.6% of the species range. In addition, this population is a unique case where urban expansion favours contact zones between Barbary macaque habitats and a big city (Bejaia). We quantified the dietary composition of Gouraya macaques over an annual cycle with the objective to understand how diet flexibility of this species may help it adapt to a relictual habitat or cope with urban expansion. We recorded the phenology of plant species every month. This study shows that Gouraya macaques, compared to those living in other forest types of the distribution area, are under lower seasonal constraints. They consume a greater amount of fruit and seeds that are available throughout much of the year, and a lesser amount of costly to find and extract subterranean foods. Therefore the Gouraya relictual habitat appears as a favourable environment compared to other major habitats of that species. This study also shows that colonizing peri-urban zones increases the availability and species richness of diet resources for Barbary macaques as they consume more human foods and exotic plants than in farther sites. Adult males eat more human foods than adult females and immatures do. The exploitation of high-energy anthropogenic food could favour macaque population growth and expansion towards the city center associated with human/macaque conflicts. We recommend applying management actions to restore macaques back to their natural habitat. PMID:25714476

  12. Is diet flexibility an adaptive life trait for relictual and peri-urban populations of the endangered primate Macaca sylvanus?

    Directory of Open Access Journals (Sweden)

    Yasmina Maibeche

    Full Text Available Habitat loss, fragmentation and urban expansion may drive some species to marginal habitats while others succeed in exploiting urban areas. Species that show dietary flexibility are more able to take advantage of human activities to supplement their diet with anthropogenically abundant and accessible resources. The Barbary macaque (Macaca sylvanus is an endangered species due to the loss of its habitat, and human pressure. The population of Gouraya National Park (Algeria lives in a relictual habitat that constitutes about 0.6% of the species range. In addition, this population is a unique case where urban expansion favours contact zones between Barbary macaque habitats and a big city (Bejaia. We quantified the dietary composition of Gouraya macaques over an annual cycle with the objective to understand how diet flexibility of this species may help it adapt to a relictual habitat or cope with urban expansion. We recorded the phenology of plant species every month. This study shows that Gouraya macaques, compared to those living in other forest types of the distribution area, are under lower seasonal constraints. They consume a greater amount of fruit and seeds that are available throughout much of the year, and a lesser amount of costly to find and extract subterranean foods. Therefore the Gouraya relictual habitat appears as a favourable environment compared to other major habitats of that species. This study also shows that colonizing peri-urban zones increases the availability and species richness of diet resources for Barbary macaques as they consume more human foods and exotic plants than in farther sites. Adult males eat more human foods than adult females and immatures do. The exploitation of high-energy anthropogenic food could favour macaque population growth and expansion towards the city center associated with human/macaque conflicts. We recommend applying management actions to restore macaques back to their natural habitat.

  13. Adaptation of the Asthma Quality of Life Questionnaire to a second language preserves its critical properties: the Spanish version.

    Science.gov (United States)

    Sanjuás, C; Alonso, J; Ferrer, M; Curull, V; Broquetas, J M; Antó, J M

    2001-02-01

    To test the metric proprieties of the Spanish version of the Juniper Asthma Quality of Life Questionnaire (AQLQ), we studied 116 adult asthmatic patients with a wide range of disease severity (53 patients were recruited from the respiratory outpatient department, 38 from a primary health care centre and 25 were patients admitted into hospital due to acute asthma). The patients were assessed twice, at recruitment and after 2 months. The AQLQ showed a high internal consistency (Cronbach's alpha = 0.78 to 0.96) and a high 2-week reproducibility (ICC = 0.82 to 0.92). Expected significant differences in AQLQ scores were observed according to disease severity as measured by symptoms, medication, use of services and recruitment setting. The cross-sectional and longitudinal correlations between AQLQ and the overall St. George's Respiratory Questionnaire were strong, moderate to strong between AQLQ and dyspnea and weak to moderate between AQLQ and FEV(1). The changes in AQLQ scores were significantly different in patients who either improved or deteriorated from those patients who remained stable (P <.0001 and P <.01, respectively, for the overall AQLQ). We conclude that the Spanish version of the AQLQ is reliable, valid and sensitive to changes. PMID:11166534

  14. Evaluating climate change adaptation options for urban flooding in Copenhagen based on new high‐end emission scenario simulations

    DEFF Research Database (Denmark)

    Arnbjerg-Nielsen, Karsten; Leonhardsen, Lykke; Madsen, Henrik

    2014-01-01

    Climate change adaptation studies on urban flooding are often based on a model chain approach from climate forcing scenarios to analysis of adaptation measures. Previous analyses of impacts in Denmark using ensemble projections of the A1B scenario are supplemented by two high‐end scenario simulat...

  15. Simulation of goat and sheep grazing dynamics and climate change adaptation strategies in West Inner Monglia, China

    NARCIS (Netherlands)

    Dai, X.; Xiong, Z.; Kramer, K.; Jia, G.; Zhao, D.

    2012-01-01

    This paper focus on climate change adaptation, land use management and grazing strategies in Alxa League, Inner Mongolia, China by use of social survey, statistical analysis and numerical modeling. Results suggest that the climate change adaptation must keep a balance between sustainable development

  16. A novel adaptive time stepping variant of the Boris-Buneman integrator for the simulation of particle accelerators with space charge

    CERN Document Server

    Toggweiler, Matthias; Arbenz, Peter; Yang, Jianjun J

    2012-01-01

    We show that adaptive time stepping in particle accelerator simulation is an enhancement for certain problems. The new algorithm has been implemented in the OPAL (Object Oriented Parallel Accelerator Library) framework, and is compared to the existing code. The idea is to adjust the frequency of costly self field calculations, which are needed to model Coulomb interaction (space charge) effects. In analogy to a Kepler orbit simulation that requires a higher time step resolution at the close encounter, we propose to choose the time step based on the magnitude of the space charge forces. Inspired by geometric integration techniques, our algorithm chooses the time step proportional to a function of the current phase space state instead of calculating a local error estimate like a conventional adaptive procedure. In this paper we build up on first observations made in recent work. A more profound argument is given on how exactly the time step should be chosen. An intermediate algorithm, initially built to allow a...

  17. Simulation of wireline sonic logging measurements acquired with Borehole-Eccentered tools using a high-order adaptive finite-element method

    KAUST Repository

    Pardo, David

    2011-07-01

    The paper introduces a high-order, adaptive finite-element method for simulation of sonic measurements acquired with borehole-eccentered logging instruments. The resulting frequency-domain based algorithm combines a Fourier series expansion in one spatial dimension with a two-dimensional high-order adaptive finite-element method (FEM), and incorporates a perfectly matched layer (PML) for truncation of the computational domain. The simulation method was verified for various model problems, including a comparison to a semi-analytical solution developed specifically for this purpose. Numerical results indicate that for a wireline sonic tool operating in a fast formation, the main propagation modes are insensitive to the distance from the center of the tool to the center of the borehole (eccentricity distance). However, new flexural modes arise with an increase in eccentricity distance. In soft formations, we identify a new dipole tool mode which arises as a result of tool eccentricity. © 2011 Elsevier Inc.

  18. The SILCC (SImulating the LifeCycle of molecular Clouds) project: I. Chemical evolution of the supernova-driven ISM

    CERN Document Server

    Walch, S K; Naab, T; Gatto, A; Glover, S C O; Wünsch, R; Klessen, R S; Clark, P C; Peters, T; Baczynski, C

    2014-01-01

    The SILCC project (SImulating the Life-Cycle of molecular Clouds) aims at a more self-consistent understanding of the interstellar medium (ISM) on small scales and its link to galaxy evolution. We simulate the evolution of the multi-phase ISM in a 500 pc x 500 pc x 10 kpc region of a galactic disc, with a gas surface density of $\\Sigma_{_{\\rm GAS}} = 10 \\;{\\rm M}_\\odot/{\\rm pc}^2$. The Flash 4.1 simulations include an external potential, self-gravity, magnetic fields, heating and radiative cooling, time-dependent chemistry of H$_2$ and CO considering (self-) shielding, and supernova (SN) feedback. We explore SN explosions at different (fixed) rates in high-density regions (peak), in random locations (random), in a combination of both (mixed), or clustered in space and time (clustered). Only random or clustered models with self-gravity (which evolve similarly) are in agreement with observations. Molecular hydrogen forms in dense filaments and clumps and contributes 20% - 40% to the total mass, whereas most of ...

  19. Antibacterial immune competence of honey bees (Apis mellifera is adapted to different life stages and environmental risks.

    Directory of Open Access Journals (Sweden)

    Heike Gätschenberger

    Full Text Available The development of all honey bee castes proceeds through three different life stages all of which encounter microbial infections to a various extent. We have examined the immune strength of honey bees across all developmental stages with emphasis on the temporal expression of cellular and humoral immune responses upon artificial challenge with viable Escherichia coli bacteria. We employed a broad array of methods to investigate defence strategies of infected individuals: (a fate of bacteria in the haemocoel; (b nodule formation and (c induction of antimicrobial peptides (AMPs. Newly emerged adult worker bees and drones were able to activate efficiently all examined immune reactions. The number of viable bacteria circulating in the haemocoel of infected bees declined rapidly by more than two orders of magnitude within the first 4-6 h post-injection (p.i., coinciding with the occurrence of melanised nodules. Antimicrobial activity, on the other hand, became detectable only after the initial bacterial clearance. These two temporal patterns of defence reactions very likely represent the constitutive cellular and the induced humoral immune response. A unique feature of honey bees is that a fraction of worker bees survives the winter season in a cluster mostly engaged in thermoregulation. We show here that the overall immune strength of winter bees matches that of young summer bees although nodulation reactions are not initiated at all. As expected, high doses of injected viable E.coli bacteria caused no mortality in larvae or adults of each age. However, drone and worker pupae succumbed to challenge with E.coli even at low doses, accompanied by a premature darkening of the pupal body. In contrast to larvae and adults, we observed no fast clearance of viable bacteria and no induction of AMPs but a rapid proliferation of E.coli bacteria in the haemocoel of bee pupae ultimately leading to their death.

  20. A Simulation Study Comparing Incineration and Composting in a Mars-Based Advanced Life Support System

    Science.gov (United States)

    Hogan, John; Kang, Sukwon; Cavazzoni, Jim; Levri, Julie; Finn, Cory; Luna, Bernadette (Technical Monitor)

    2000-01-01

    The objective of this study is to compare incineration and composting in a Mars-based advanced life support (ALS) system. The variables explored include waste pre-processing requirements, reactor sizing and buffer capacities. The study incorporates detailed mathematical models of biomass production and waste processing into an existing dynamic ALS system model. The ALS system and incineration models (written in MATLAB/SIMULINK(c)) were developed at the NASA Ames Research Center. The composting process is modeled using first order kinetics, with different degradation rates for individual waste components (carbohydrates, proteins, fats, cellulose and lignin). The biomass waste streams are generated using modified "Eneray Cascade" crop models, which use light- and dark-cycle temperatures, irradiance, photoperiod, [CO2], planting density, and relative humidity as model inputs. The study also includes an evaluation of equivalent system mass (ESM).

  1. Modeling and simulation in the systems engineering life cycle core concepts and accompanying lectures

    CERN Document Server

    Loper, Margaret L

    2015-01-01

    This easy to read text/reference provides a broad introduction to the fundamental concepts of modeling and simulation (M&S) and systems engineering, highlighting how M&S is used across the entire systems engineering lifecycle. Each chapter corresponds to a short lecture covering a core topic in M&S or systems engineering.  Topics and features: reviews the full breadth of technologies, methodologies and uses of M&S, rather than just focusing on a specific aspect of the field; presents contributions from renowned specialists in each topic covered; introduces the foundational elements and proce

  2. Accelerated multiscale space-time finite element simulation and application to high cycle fatigue life prediction

    Science.gov (United States)

    Zhang, Rui; Wen, Lihua; Naboulsi, Sam; Eason, Thomas; Vasudevan, Vijay K.; Qian, Dong

    2016-08-01

    A multiscale space-time finite element method based on time-discontinuous Galerkin and enrichment approach is presented in this work with a focus on improving the computational efficiencies for high cycle fatigue simulations. While the robustness of the TDG-based space-time method has been extensively demonstrated, a critical barrier for the extensive application is the large computational cost due to the additional temporal dimension and enrichment that are introduced. The present implementation focuses on two aspects: firstly, a preconditioned iterative solver is developed along with techniques for optimizing the matrix storage and operations. Secondly, parallel algorithms based on multi-core graphics processing unit are established to accelerate the progressive damage model implementation. It is shown that the computing time and memory from the accelerated space-time implementation scale with the number of degree of freedom N through ˜ O(N^{1.6}) and ˜ O(N), respectively. Finally, we demonstrate the accelerated space-time FEM simulation through benchmark problems.

  3. Toward Online Adaptive Hyperthermia Treatment Planning: Correlation Between Measured and Simulated Specific Absorption Rate Changes Caused by Phase Steering in Patients

    Energy Technology Data Exchange (ETDEWEB)

    Kok, H. Petra, E-mail: H.P.Kok@amc.uva.nl [Department of Radiation Oncology, Academic Medical Center, University of Amsterdam, Amsterdam (Netherlands); Ciampa, Silvia [Department of Radiation Oncology, Academic Medical Center, University of Amsterdam, Amsterdam (Netherlands); Department of Civil Engineering and Computer Science, University of Rome Tor Vergata, Rome (Italy); Kroon-Oldenhof, Rianne de; Steggerda-Carvalho, Eva J.; Stam, Gerard van; Zum Vörde Sive Vörding, Paul J.; Stalpers, Lukas J.A.; Geijsen, Elisabeth D. [Department of Radiation Oncology, Academic Medical Center, University of Amsterdam, Amsterdam (Netherlands); Bardati, Fernando [Department of Civil Engineering and Computer Science, University of Rome Tor Vergata, Rome (Italy); Bel, Arjan; Crezee, Johannes [Department of Radiation Oncology, Academic Medical Center, University of Amsterdam, Amsterdam (Netherlands)

    2014-10-01

    Purpose: Hyperthermia is the clinical application of heat, in which tumor temperatures are raised to 40°C to 45°C. This proven radiation and chemosensitizer significantly improves clinical outcome for several tumor sites. Earlier studies of the use of pre-treatment planning for hyperthermia showed good qualitative but disappointing quantitative reliability. The purpose of this study was to investigate whether hyperthermia treatment planning (HTP) can be used more reliably for online adaptive treatment planning during locoregional hyperthermia treatments. Methods and Materials: This study included 78 treatment sessions for 15 patients with non-muscle-invasive bladder cancer. At the start of treatments, temperature rise measurements were performed with 3 different antenna settings optimized for each patient, from which the absorbed power (specific absorption rate [SAR]) was derived. HTP was performed based on a computed tomography (CT) scan in treatment position with the bladder catheter in situ. The SAR along the thermocouple tracks was extracted from the simulated SAR distributions. Correlations between measured and simulated (average) SAR values were determined. To evaluate phase steering, correlations between the changes in simulated and measured SAR values averaged over the thermocouple probe were determined for all 3 combinations of antenna settings. Results: For 42% of the individual treatment sessions, the correlation coefficient between measured and simulated SAR profiles was higher than 0.5, whereas 58% showed a weak correlation (R of <0.5). The overall correlation coefficient between measured and simulated average SAR was weak (R=0.31; P<.001). The measured and simulated changes in average SAR after adapting antenna settings correlated much better (R=0.70; P<.001). The ratio between the measured and simulated quotients of maximum and average SARs was 1.03 ± 0.26 (mean ± SD), indicating that HTP can also correctly predict the relative amplitude of

  4. An origin-of-life reactor to simulate alkaline hydrothermal vents.

    Science.gov (United States)

    Herschy, Barry; Whicher, Alexandra; Camprubi, Eloi; Watson, Cameron; Dartnell, Lewis; Ward, John; Evans, Julian R G; Lane, Nick

    2014-12-01

    Chemiosmotic coupling is universal: practically all cells harness electrochemical proton gradients across membranes to drive ATP synthesis, powering biochemistry. Autotrophic cells, including phototrophs and chemolithotrophs, also use proton gradients to power carbon fixation directly. The universality of chemiosmotic coupling suggests that it arose very early in evolution, but its origins are obscure. Alkaline hydrothermal systems sustain natural proton gradients across the thin inorganic barriers of interconnected micropores within deep-sea vents. In Hadean oceans, these inorganic barriers should have contained catalytic Fe(Ni)S minerals similar in structure to cofactors in modern metabolic enzymes, suggesting a possible abiotic origin of chemiosmotic coupling. The continuous supply of H2 and CO2 from vent fluids and early oceans, respectively, offers further parallels with the biochemistry of ancient autotrophic cells, notably the acetyl CoA pathway in archaea and bacteria. However, the precise mechanisms by which natural proton gradients, H2, CO2 and metal sulphides could have driven organic synthesis are uncertain, and theoretical ideas lack empirical support. We have built a simple electrochemical reactor to simulate conditions in alkaline hydrothermal vents, allowing investigation of the possibility that abiotic vent chemistry could prefigure the origins of biochemistry. We discuss the construction and testing of the reactor, describing the precipitation of thin-walled, inorganic structures containing nickel-doped mackinawite, a catalytic Fe(Ni)S mineral, under prebiotic ocean conditions. These simulated vent structures appear to generate low yields of simple organics. Synthetic microporous matrices can concentrate organics by thermophoresis over several orders of magnitude under continuous open-flow vent conditions.

  5. Simulations

    CERN Document Server

    Ngada, N M

    2015-01-01

    The complexity and cost of building and running high-power electrical systems make the use of simulations unavoidable. The simulations available today provide great understanding about how systems really operate. This paper helps the reader to gain an insight into simulation in the field of power converters for particle accelerators. Starting with the definition and basic principles of simulation, two simulation types, as well as their leading tools, are presented: analog and numerical simulations. Some practical applications of each simulation type are also considered. The final conclusion then summarizes the main important items to keep in mind before opting for a simulation tool or before performing a simulation.

  6. Low Earth orbit journey and ground simulations studies point out metabolic changes in the ESA life support organism Rhodospirillum rubrum

    Science.gov (United States)

    Mastroleo, Felice; Leys, Natalie; Benotmane, Rafi; Vanhavere, Filip; Janssen, Ann; Hendrickx, Larissa; Wattiez, Ruddy; Mergeay, Max

    MELiSSA (Micro-Ecological Life Support System Alternative) is a project of closed regenerative life support system for future space flights developed by the European Space Agency. It consists of interconnected processes (i.e. bioreactors, higher plant compartments, filtration units,..) targeting the total recycling of organic waste into oxygen, water and food. Within the MELiSSA loop, the purple non-sulfur alpha-proteobacterium R. rubrum ATCC25903 is used to convert fatty acids released from the upstream raw waste digesting reactor to CO2 and biomass, and to complete the mineralization of aminoacids into NH4+ that will be forwarded to the nitrifying compartment. Among the numerous challenges of the project, the functional stability of the bioreactors in long term and under space flight conditions is of paramount importance for the efficiency of the life support system and consequently the crew safety. Therefore, the physiological and metabolic changes induced by space flight were investigated for R. rubrum. The bacterium grown on solid medium during 2 different 10-day space flights to the ISS (MES- SAGE2, BASE-A experiments) were compared to cells grown on Earth 1 g gravity or modeled microgravity and normal Earth radiation or simulated space flight radiation conditions in order to relate each single stress to its respective cellular response. For simulating the radiation environment, pure gamma and neutron sources were combined, while simulation of changes in gravity where performed using the Random Positioning Machine technology. Transcriptome analysis using R. rubrum total genome DNA-chip showed up-regulation of genes involved in oxidative stress response after a 10-day mission inside the ISS, without loss of viability. As an example, alkyl hydroperoxide reductase, thioredoxin reductase and bacterioferritin genes are least 2 fold induced although the radiation dose experienced by the bacterium (4 mSv) is very low compared to its radiotolerance (D10 = 100 Sv

  7. Simulation of Prebiotic Processing by Comet and Meteoroid Impact: Implications for Life on Early Earth and Other Planets

    Science.gov (United States)

    Dateo, Christopher E.

    2003-01-01

    We develop a reacting flow model to simulate the shock induced chemistry of comets and meteoroids entering planetary atmospheres. Various atmospheric compositions comprising of simpler molecules (i.e., CH4, CO2, H2O, etc.) are investigated to determine the production efficiency of more complex prebiotic molecules as a function of composition, pressure, and entry velocity. The possible role of comets and meteoroids in creating the inventory of prebiotic material necessary for life on Early Earth is considered. Comets and meteoroids can also introduce new materials from the Interstellar Medium (ISM) to planetary atmospheres. The ablation of water from comets, introducing the element oxygen into Titan's atmosphere will also be considered and its implications for the formation of organic and prebiotic material.

  8. Carbide evolution and service life of simulated post weld heat treated 2.25Cr–1Mo steel

    International Nuclear Information System (INIS)

    To estimate the service life of the reactor internals made of 2.25Cr–1Mo steel in the high temperature gas-cooled reactor pebble-bed module demonstration plant, creep rupture test was performed on the simulated post weld heat treated steel at 773 K over a range of stress levels 300–200 MPa. It has been shown that the rupture time is 126–5532 h, correspondingly. Then, the service life under stress of 161.2 MPa at 648 K was calculated to be so long as 210,374,853 h (≈24,015 years). Four types of carbides M3C, M2C, M7C3 and M23C6 existed in both the steel plate and the post-rupture specimens. As the rupture time increases, the weight percentages of M23C6 and M2C that are stable in thermodynamics in the post-rupture specimens increase while those of metastable M3C and M7C3 decrease on the whole. During the long term creep exposure, the deformation promotes the precipitation of M3C, M2C and M23C6, according to the experimental results with the deformed and undeformed parts of the post-rupture specimens, but its influence on the weight percentage of M7C3 seems rather complicated

  9. The Relationship of Life Planning and Social Adaptive Behavior of College Students%大学生人生规划与社会适应行为的关系

    Institute of Scientific and Technical Information of China (English)

    王雄伟

    2012-01-01

    1920 students were investigated about their social adaptive behavior and life planning. Results Life planning and social adaptive behavior of college students were at the upper-middle level in general, and there was a significant difference in gender. College students' life planning was positive correlated with the social adaptive behaviors (r = 0. 404). Conclusions College students' life planning was a predictor of social adaptive behavior.%目的 探索大学生一般人生规划与社会适应行为之间的关系.方法 对兰州市1 920名大学生进行问卷调查研究.结果 大学生社会适应行为与人生规划总体较好,平均分(社会适应行为19.02;人生规划9.81)在中等水平以上,人生规划性别主效应显著;大学生人生规划与社会适应行为存在显著正相关(r=0.404);人生规划可以解释社会适应行为各维度5.9%~21.3%的变异.结论 大学生人生规划对社会适应行为有一定预测效果.

  10. FY14 Milestone: Simulated Impacts of Life-Like Fast Charging on BEV Batteries (Management Publication)

    Energy Technology Data Exchange (ETDEWEB)

    Neubauer, J.; Wood, E.; Burton, E.; Smith, K.; Pesaran, A.

    2014-09-01

    Fast charging is attractive to battery electric vehicle (BEV) drivers for its ability to enable long-distance travel and quickly recharge depleted batteries on short notice. However, such aggressive charging and the sustained vehicle operation that results could lead to excessive battery temperatures and degradation. Properly assessing the consequences of fast charging requires accounting for disparate cycling, heating, and aging of individual cells in large BEV packs when subjected to realistic travel patterns, usage of fast chargers, and climates over long durations (i.e., years). The U.S. Department of Energy's Vehicle Technologies Office has supported NREL's development of BLAST-V 'the Battery Lifetime Analysis and Simulation Tool for Vehicles' to create a tool capable of accounting for all of these factors. The authors present on the findings of applying this tool to realistic fast charge scenarios. The effects of different travel patterns, climates, battery sizes, battery thermal management systems, and other factors on battery performance and degradation are presented. The primary challenge for BEV batteries operated in the presence of fast charging is controlling maximum battery temperature, which can be achieved with active battery cooling systems.

  11. Effects of Physical Exercises on Adolescents' Psychological Adaptation and Life Satisfaction%体育锻炼对青少年心理适应性和生活满意感的影响

    Institute of Scientific and Technical Information of China (English)

    王次农; 邱达明

    2012-01-01

    心理适应和一般生活满意感都是心理健康的重要指标。以青少年心理适应和一般生活满意感2个量表为研究工具,对403名南昌市普通中学的高中生和普通大学生进行测试,通过相关分析、多元方差以及回归分析方法进行分析,结果显示:⑴心理适应的各个维度以及总分与生活满意感均有可靠相关(P〈0.01);在心理适应的指标中,人际适应和生活适应对生活满意感具有可靠的预测作用。⑵相对与中、大运动量来说,小运动量对于心理适应的效益最小。⑶运动量对心理适应与生活满意感的关系具有调节作用(ΔR2=0.01,P〈0.01)。%Psychological adaptation and life satisfaction are important indexes of mental health.The study investigates 403 middle school students and college students in Nanchang with two scales on adolescents' psychological adaptation and life satisfaction.The results show:(1)there are reliable correlations among all dimensions of psychological adaptation,total score and life satisfaction(P0.01).Interpersonal adaptation and life adaptation could effectively predict the life satisfaction in the index of psychological adaptation.(2)the benefit of low intensity is minimum for psychological adaptation compared with the benefit of the medium and high intensity.(3)exercise intensity could adjust the relations between psychological adaptation and life satisfaction(ΔR2=0.01,P0.01).

  12. Adaptation of birds to life in high mountains in Eurasia%鸟类对欧亚地区高山生活的适应

    Institute of Scientific and Technical Information of China (English)

    Roald L.POTAPOV

    2004-01-01

    欧亚地区高地鸟类区系的贫乏性(仅有75种繁殖于林线之上)受严酷的自然条件和食物资源短缺所决定.适合这些条件的主要适应是飞行模式,包括与之有关的形态特征,繁殖时间的选择,最优化利用微生境和伪装的巢址选择,窝卵数的限制,对雏鸟的食物转运模式,防护强紫外线辐射和大气干燥.大多数欧亚高地鸟类的生活史特征有待于进一步研究[动物学报 50(6):970-977,2004].%The paucity of the avifauna of the Eurasian highlands (only 75 species breed regularly above the timber line) is determined by severe natural conditions and scarcity of food sources. Principal adaptations to meet these conditions are in modes of flight, including morphological peculiarities connected with them, choice of time of breeding and nesting places which optimize use of microclimate and camouflage, limitation of clutch size, mode of transportation of food to nestlings, and protection from strong ultraviolet radiation and atmospheric desiccation. Most life history characteristics of Eurasian highland bird life need further research[Acta Zoologica Sinica 50(6):970-977,2004].

  13. Production dynamics and life cycle of dominant chironomids (Diptera, Chironomidae) in a subtropical stream in China: adaptation to variable flow conditions in summer and autumn

    Institute of Scientific and Technical Information of China (English)

    2007-01-01

    The production dynamics and trophic basis of 7 dominant species of chironomids were investigated in the area of a second-order river of the Hanjiang River basin, in central China from June 2003 to June 2004. The results showed that Tvetenia discoloripes was by far the most abundant chironomid, dominating the overall standing stock of the taxa. In terms of life cycle, Chaetocladius sp.,Eukiefferiella potthasti and T. discoloripes developed 1 generation a year, whereas Microtendipes sp. and Pagastia sp. developed two, while Pentaneura sp. and Polypedilum sp. developed three. T. discoloripes was the most productive chironomid with 120.305 8 g/m2.a, Pentaneura sp.and E. potthasti had relatively high production values of >17 g/m2.a, and the rest were <10 g/m2.a. All the production temporal variation tended to follow biomass patterns. T. discoloripes, Chaetocladius sp. and Pagastia sp. concentrated most of their production in winter, whereas E. potthasti, Pentaneura sp. and Polypedilum sp. had relatively higher production throughout the year. Only Microtendipes sp. had a production that peaked in summer.The overlap in temporal distribution of production among the chironomid species was generally high (>0.5), especially for filter-collectors Microtendipes sp., Chaetocladius sp., Chaetocladius sp., T.discoloripes and Pagastia sp. All species except Pentaneura sp. consumed a large portion of amorphous detritus, constituting more than 90% of their diets, and contributing nearly 90% to their secondary production. All the 7 chironomids represent obvious adaptation to local highly variable climate in summer and autumn in life cycle pattern, production dynamics, and food type.

  14. The unique adaptation of the life cycle of the coelomic gregarine Diplauxis hatti to its host Perinereis cultrifera (Annelida, Polychaeta): an experimental and ultrastructural study.

    Science.gov (United States)

    Prensier, Gerard; Dubremetz, Jean-Francois; Schrevel, Joseph

    2008-01-01

    The coelomic gregarine Diplauxis hatti exhibits a unique adaptation of its life cycle to its polychaete host Perinereis cultrifera. Experimental and ultrastructural observations on natural populations from the English Channel showed that release of parasite spores is concomitant with the polychaete spawning. As the development of P. cultrifera is direct, the notochete larva ingest parts of the jelly coat covered with numerous sporocysts of D. hatti during hatching. Transepithelial migration of the sporozoites takes place in the gut of three- or four-segment notochete larvae and syzygies of about 20 microm are observed in the coelom. Growth of these young syzygies is slow: after 18-24 mo they reach only 60-70 microm. They exhibit active pendular movements. In the English Channel, female and male gametogenesis of P. cultrifera begins at 19 mo and 2 yr, respectively; the somatic transformations (epitoky) in the last 4 mo of their 3-year life. During epitoky, the syzygies undergo an impressive growth and reach 700-800 microm within a few weeks. A shift from pendular to active peristaltic motility is observed when the syzygies reach 200-250 microm. When gamogony occurs, syncytial nuclear divisions are initiated and cellularization produces hundred to thousands of male and female gametes of similar size. The male gametes exhibit a flagellum with 3+0 axoneme. The mixing of the gametes ("danse des gametes") and fertilization are observed during 4-5 h. Zygotes differentiate sporoblasts with eight sporozoites. The sporozoites exhibit the canonical structure of Apicomplexa, a polarized cell with micronemes and rhoptries. PMID:19120801

  15. Cultural adaptation and validation of the “Kidney Disease and Quality of Life - Short Form (KDQOL-SF™ version 1.3” questionnaire in Egypt

    Directory of Open Access Journals (Sweden)

    Abd ElHafeez Samar

    2012-12-01

    Full Text Available Abstract Background Health Related Quality of Life (HRQOL instruments need disease and country specific validation. In Arab countries, there is no specific validated questionnaire for assessment of HRQOL in chronic kidney disease (CKD patients. The aim of this study was to present an Arabic translation, adaptation, and the subsequent validation of the kidney disease quality of life-short form (KDQOL-SFTM version 1.3 questionnaire in a representative series of Egyptian CKD patients. Methods KDQOL-SFTM version 1.3 was translated into Arabic by two independent translators, and then subsequently translated back into English. After translation disparities were reconciled, the final Arabic questionnaire was tested by interviewing 100 pre-dialysis CKD (stage 1-4 patients randomly selected from outpatients attending the Nephrology clinic at the Main Alexandria University Hospital. Test re-test reliability was performed, with a subsample of 50 consecutive CKD patients, by two interviews 7 days apart and internal consistency estimated by Cronbach’s α. Discriminant, concept, and construct validity were assessed. Results All items of SF-36 met the criterion for internal consistency and were reproducible. Of the 10 kidney disease targeted scales, only three had Cronbach’s α TM 1.3 were significantly inter-correlated. Finally, principal component analysis of the kidney disease targeted scale indicated that this part of the questionnaire could be summarized into 10 factors that together explained 70.9% of the variance. Conclusion The results suggest that this Arabic version of the KDQOL-SFTM 1.3 questionnaire is a valid and reliable tool for use in Egyptian patients with CKD.

  16. The semi-implicit, adaptive Multi-Level Multi-Domain method for Particle In Cell plasma simulations

    Science.gov (United States)

    Innocenti, Maria Elena; Markidis, Stefano; Lapenta, Giovanni

    2015-11-01

    The Multi Level Multi Domain (MLMD) method (Innocenti (2013), Beck (2014)) is a fully kinetic, semi-implicit PIC method which simulates a domain as a collection of sub-domains where increasingly higher resolution is used. The aim is to reduce the computational costs of PIC simulations: simulations which are computationally challenging even with a traditional semi-implicit PIC code, e.g., realistic mass ratio simulations, become feasible with moderate computational resources. We present two sets of realistic mass ratio simulations: magnetic reconnection and Lower Hybrid Drift Instability (LHDI). MLMD reconnection simulations are discussed in Innocenti (2015). In the MLMD LHDI simulations, we show how the MLMD method cheaply extends the range of simulatedwavenumbers with respect to traditional simulations. We simulate the three LHDI stages (fast and slow LHDI branch, kink instability), which are well separated in wavenumber at realistic mass ratio. The coupling observed by Norgren (2012) between the magnetic field and perpendicular electric field LHDI oscillations in the magnetotail is investigated in these different stages. NERSC, Contract N. DE-AC02-05CH11231, PRACE SuperMUC, contract N. 2013091928, FWO, grant N. 12O5215N.

  17. FATIGUE LIFE PREDICTION OF CRANKSHAFT MADE OF MATERIAL 48MnV BASED ON FATIGUE TESTS,DYNAMIC SIMULATION AND FEA

    Institute of Scientific and Technical Information of China (English)

    ZHANG Guoqing; PU Gengqiang; WANG Chengtao

    2006-01-01

    S-N curve and fatigue parameters of 48MnV are obtained using small sample tests and staircase or up and down method, which paves the way for predicting fatigue life of crankshaft made of 48MnV. The fatigue life of the crankshaft of a six-cylinder engine is calculated using different damage models such as S-N method, normal strain approach, Smoth-Watson-Topper (SWT)-Bannantine approach, shear strain approach, and Fatemi-Socie method based on dynamic simulation and finite element analysis (FEA) of crankshaft. The results indicate that the traditional calculation is conservative and the residual fatigue life of crankshaft is sufficient to maintain next life cycle if the crankshaft is remanufactured after its end of life.

  18. Simulation of tumor induced angiogenesis using an analytical adaptive modeling including dynamic sprouting and blood flow modeling.

    Science.gov (United States)

    Naghavi, Nadia; Hosseini, Farideh S; Sardarabadi, Mohammad; Kalani, Hadi

    2016-09-01

    In this paper, an adaptive model for tumor induced angiogenesis is developed that integrates generation and diffusion of a growth factor originated from hypoxic cells, adaptive sprouting from a parent vessel, blood flow and structural adaptation. The proposed adaptive sprout spacing model (ASS) determines position, time and number of sprouts which are activated from a parent vessel and also the developed vascular network is modified by a novel sprout branching prediction algorithm. This algorithm couples local vascular endothelial growth factor (VEGF) concentrations, stresses due to the blood flow and stochastic branching to the structural reactions of each vessel segment in response to mechanical and biochemical stimuli. The results provide predictions for the time-dependent development of the network structure, including the position and diameters of each segment and the resulting distributions of blood flow and VEGF. Considering time delays between sprout progressions and number of sprouts activated at different time durations provides information about micro-vessel density in the network. Resulting insights could be useful for motivating experimental investigations of vascular pattern in tumor induced angiogenesis and development of therapies targeting angiogenesis. PMID:27179697

  19. [Realization of an adaptive method of simulating the process of temperature change of a cadaver on a microcomputer].

    Science.gov (United States)

    Shved, E F; Novikov, P I; Vlasov, A Iu

    1989-01-01

    Programme based on mathematical model of the process of dead body temperature changing was developed for estimation of postmortem interval. Automatic retrieval of problem solution was performed on programmable microcalculators of "Electronica MK-61" type using adaptive approach. Diagnostical accuracy in case of dead body being preserved in permanent cooling conditions is +/- 3%.

  20. Investigation of Bio-Regenerative Life Support and Trash-to-Gas Experiment on a 4-Month Mars Simulation Mission

    Science.gov (United States)

    Caraccio, Anne; Poulet, Lucie; Hintze, Paul E.; Miles, John D.

    2014-01-01

    Future crewed missions to other planets or deep space locations will require regenerative Life Support Systems (LSS) as well as recycling processes for mission waste. Constant resupply of many commodity materials will not be a sustainable option for deep space missions, nor will stowing trash on board a vehicle or at a lunar or Martian outpost. The habitable volume will decline as the volume of waste increases. A complete regenerative environmentally controlled life support system (ECLSS) on an extra-terrestrial outpost will likely include physico-chemical and biological technologies, such as bioreactors and greenhouse modules. Physico-chemical LSS do not enable food production and bio-regenerative LSS are not stable enough to be used alone in space. Mission waste that cannot be recycled into the bio-regenerative ECLSS can include excess food, food packaging, clothing, tape, urine and fecal waste. This waste will be sent to a system for converting the trash into high value products. Two crew members on a 120 day Mars analog simulation, in collaboration with Kennedy Space Centers (KSC) Trash to Gas (TtG) project investigated a semi-closed loop system that treated non-edible biomass and other logistical waste for volume reduction and conversion into useful commodities. The purpose of this study is to show how plant growth affects the amount of resources required by the habitat and how spent plant material can be recycled. Real-time data was sent to the reactor at KSC in Florida for replicating the analog mission waste for laboratory operation. This paper discusses the 120 day mission plant growth activity, logistical and plant waste management, power and water consumption effects of the plant and logistical waste, and potential energy conversion techniques using KSCs TtG technology.