Organic petrology of the Aptian-age section in the downdip Mississippi Interior Salt Basin, Mississippi, USA: Observations and preliminary implications for thermal maturation history

Science.gov (United States)

Valentine, Brett J.; Hackley, Paul C.; Enomoto, Catherine B.; Bove, Alana M.; Dulong, Frank T.; Lohr, Celeste D.; Scott, Krystina R.

2014-01-01

This study identifies a thermal maturity anomaly within the downdip Mississippi Interior Salt Basin (MISB) of southern Mississippi, USA, through examination of bitumen reflectance data from Aptian-age strata (Sligo Formation, Pine Island Shale, James Limestone, and Rodessa Formation). U.S. Geological Survey (USGS) reconnaissance investigations conducted in 2011–2012 examined Aptian-age thermal maturity trends across the onshore northern Gulf of Mexico region and indicated that the section in the downdip MISB is approaching the wet gas/condensate window (Ro~1.2%). A focused study in 2012–2013 used 6 whole core, one sidewall core, and 49 high-graded cutting samples (depth range of 13,000–16,500 ft [3962.4–5029.2 m] below surface) collected from 15 downdip MISB wells for mineralogy, fluid inclusion, organic geochemistry, and organic petrographic analysis. Based on native solid bitumen reflectance (Ro generally > 0.8%; interpreted to be post-oil indigenous bitumens matured in situ), Ro values increase regionally across the MISB from the southeast to the northwest. Thermal maturity in the eastern half of the basin (Ro range 1.0 to 1.25%) appears to be related to present-day burial depth and shows a gradual increase with respect to depth. To the west, thermal maturity continues to increase even as the Aptian section shallows structurally on the Adams County High (Ro range 1.4 to > 1.8%). After evaluating the possible thermal agents responsible for increasing maturity at shallower depths (i.e., igneous activity, proximity to salt, variations in regional heat flux, and uplift), we tentatively propose that either greater paleoheat flow or deeper burial coupled with uplift in the western part of the MISB could be responsible for the thermal maturity anomaly. Further research and additional data are needed to determine the cause(s) of the thermal anomaly.

Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice

Directory of Open Access Journals (Sweden)

Postina Rolf

2009-02-01

Full Text Available Abstract Background In a transgenic mouse model of Alzheimer disease (AD, cleavage of the amyloid precursor protein (APP by the α-secretase ADAM10 prevented amyloid plaque formation, and alleviated cognitive deficits. Furthermore, ADAM10 overexpression increased the cortical synaptogenesis. These results suggest that upregulation of ADAM10 in the brain has beneficial effects on AD pathology. Results To assess the influence of ADAM10 on the gene expression profile in the brain, we performed a microarray analysis using RNA isolated from brains of five months old mice overexpressing either the α-secretase ADAM10, or a dominant-negative mutant (dn of this enzyme. As compared to non-transgenic wild-type mice, in ADAM10 transgenic mice 355 genes, and in dnADAM10 mice 143 genes were found to be differentially expressed. A higher number of genes was differentially regulated in double-transgenic mouse strains additionally expressing the human APP[V717I] mutant. Overexpression of proteolytically active ADAM10 affected several physiological pathways, such as cell communication, nervous system development, neuron projection as well as synaptic transmission. Although ADAM10 has been implicated in Notch and β-catenin signaling, no significant changes in the respective target genes were observed in adult ADAM10 transgenic mice. Real-time RT-PCR confirmed a downregulation of genes coding for the inflammation-associated proteins S100a8 and S100a9 induced by moderate ADAM10 overexpression. Overexpression of the dominant-negative form dnADAM10 led to a significant increase in the expression of the fatty acid-binding protein Fabp7, which also has been found in higher amounts in brains of Down syndrome patients. Conclusion In general, there was only a moderate alteration of gene expression in ADAM10 overexpressing mice. Genes coding for pro-inflammatory or pro-apoptotic proteins were not over-represented among differentially regulated genes. Even a decrease of

An Assessment of Mississippi's Nonindustrial Private Forest Landowners' Knowledge of Forest Best Management Practices

Science.gov (United States)

Andrew James Londo; John Benkert Auel

2004-01-01

This study examined the knowledge levels of Mississippi nonindustrial private forest (NIPF) landowners relative to best management practices (BMPs) for water quality. Data were collected through surveys of participants in BMP programs held in conjunction with County Forestry Association (CFA) meetings throughout Mississippi during 2001-02. Ten CFAs participated in this...

John Bertram Adams

International Nuclear Information System (INIS)

Stafford, G.H.

1986-01-01

This is the biography of a man obviously much liked and respected. It gives some personal details but is mainly concerned with his scientific work and achievements on major projects. Thus, some background information on those projects is also given as a context to the work of John Adams. The biography is written in sections; early years, the creation of CERN, Adams at CERN 1953-61, Adams and thermonuclear research 1958-69, (which includes his Directorship of the Culham Laboratory), Adams and the Ministry of Technology 1965-66, member for research of the UK Atomic Energy Authority 1966-69, Adams at CERN 1969-84 (as Director General of the SPS, as Executive Director-General of CERN 1979-81 and work at CERN up to 1984). (UK)

The Summer Food Service Program and the Ongoing Hunger Crisis in Mississippi.

Science.gov (United States)

Cobern, Jade A; Shell, Kathryn J; Henderson, Everett R; Beech, Bettina M; Batlivala, Sarosh P

2015-10-01

Food insecurity is simply defined as uncertain access to adequate food. Nearly 50 million Americans, 16 million of whom are children, are food insecure. Mississippi has 21% food insecure citizens, and has the most food insecure county in the nation. Our state's school system's National Breakfast and Lunch Programs help combat food insecurity, but a gap still exists. This gap widens during the summer. In this paper, we describe the Mississippi Summer Food Service Program. While the program has had success in our state, it still faces challenges. Organized action by physicians in Mississippi and the Mississippi State Medical Association could significantly increase participation in these programs that are vital to our state.

Initial estimates of hurricane Katrina impacts of Mississippi gulf coast forest resources

Science.gov (United States)

Patrick A. Glass; Sonja N. Oswalt

2007-01-01

Hurricane Katrina pummeled the Gulf Coast of Mississippi on August 29, 2005. The eye wall of the storm passed directly over Hancock and Pearl River Counties. Harrison, Jackson, Stone, and George Counties on the windward side of the hurricane's path sustained severe damage before the storm's strength dissipated as it moved farther inland (fig. 1).

Post-Closure Inspection and Monitoring Report for the Salmon, Mississippi, Site Calendar Year 2007

International Nuclear Information System (INIS)

2008-01-01

This report summarizes inspection and monitoring activities performed on and near the Salmon, Mississippi, Site in calendar year 2007. The Draft Long-Term Surveillance and Maintenance Plan for the Salmon Site, Lamar County, Mississippi (DOE 2007) specifies the submittal of an annual report of site activities and the results of sample analyses. This report is submitted to comply with that requirement. The Tatum Salt Dome was used by the U.S. Atomic Energy Commission (AEC) for underground nuclear testing during the cold war. The land surface above the salt dome, the Salmon Site, is located in Lamar County, Mississippi, approximately 12 miles west of Purvis (Figure 1). The U.S. Department of Energy (DOE), the successor to the AEC, is responsible for long-term surveillance and maintenance of the site. The DOE Office of Legacy Management (LM) was assigned this responsibility effective October 2006

County business patterns, 1997 : Mississippi

Science.gov (United States)

1999-09-01

County Business Patterns is an annual series that provides : subnational economic data by industry. The series is : useful for studying the economic activity of small areas; : analyzing economic changes over time; and as a benchmark : for statistical...

Urban and community forests of the South Central East region: Alabama, Kentucky, Mississippi, Tennessee

Science.gov (United States)

David J. Nowak; Eric J. Greenfield

2010-01-01

This report details how land cover and urbanization vary within the states of Alabama, Kentucky, Mississippi, and Tennessee by community (incorporated and census designated places), county subdivision, and county. Specifically this report provides critical urban and community forestry information for each state including human population characteristics and trends,...

Health assessment for Westinghouse Elevator, Cumberland Township, Adams County, Pennsylvania, Region 3. CERCLIS No. PAD043882281. Preliminary report

Energy Technology Data Exchange (ETDEWEB)

1989-01-19

The Westinghouse Elevator site in Adams County, Pennsylvania has been in operation since 1968 as an elevator component manufacturing facility. During the process of elevator cab production, parts were passed through a degreasing and paint phase. Sampling of nearby surface water in 1983 revealed contamination with organic solvents. The environmental contamination on-site consists of 1,1,1-trichloroethane and trichloroethylene in surface sludge, soil, surface water, sediment, and groundwater. In addition, 1,1-dichloroethane and 1,1-dichloroethylene were detected in soil. The environmental contamination off-site consists of 1,1,1-trichloroethane, 1,1-dichloroethylene, 1,1-dichloroethane, and trichloroethylene in residential water supply wells. Contaminated groundwater is of primary importance to the site. Private wells have been found to be contaminated and alternate water supplies have been provided. One public supply well has been decommissioned due to contamination. The site is considered to be of potential public health concern because of the risk to human health caused by the possibility of exposure to hazardous substances via contaminated groundwater, surface water, sediment, and possibly on-site soil.

Preferred SH3 domain partners of ADAM metalloproteases include shared and ADAM-specific SH3 interactions.

Directory of Open Access Journals (Sweden)

Iivari Kleino

Full Text Available A disintegrin and metalloproteinases (ADAMs constitute a protein family essential for extracellular signaling and regulation of cell adhesion. Catalytic activity of ADAMs and their predicted potential for Src-homology 3 (SH3 domain binding show a strong correlation. Here we present a comprehensive characterization of SH3 binding capacity and preferences of the catalytically active ADAMs 8, 9, 10, 12, 15, 17, and 19. Our results revealed several novel interactions, and also confirmed many previously reported ones. Many of the identified SH3 interaction partners were shared by several ADAMs, whereas some were ADAM-specific. Most of the ADAM-interacting SH3 proteins were adapter proteins or kinases, typically associated with sorting and endocytosis. Novel SH3 interactions revealed in this study include TOCA1 and CIP4 as preferred partners of ADAM8, and RIMBP1 as a partner of ADAM19. Our results suggest that common as well as distinct mechanisms are involved in regulation and execution of ADAM signaling, and provide a useful framework for addressing the pathways that connect ADAMs to normal and aberrant cell behavior.

The role of ADAMs in disease pathophysiology.

LENUS (Irish Health Repository)

Duffy, Michael J

2012-02-01

The ADAMs are a family of multidomain transmembrane and secreted proteins involved in both proteolysis and cell adhesion. Altered expression of specific ADAMs is implicated in the pathophysiology of several diseases including rheumatoid arthritis, Alzheimer\\'s disease, cardiac hypertrophy, asthma and cancer. Of these different diseases, it is in cancer where most research has been carried out. Multiple ADAMs, including ADAM-9, ADAM-10, ADAM-12, ADAM-15 and ADAM-17, have been shown to play a role in either cancer formation or progression. Consistent with these findings, increased expression of specific ADAMs in several cancer types was found to correlate with features of aggressive disease and poor prognosis. Currently, selective ADAM inhibitors against ADAM-10 and ADAM-17 are undergoing clinical trials for the treatment of cancer. Further work is required in order to establish a causative role for ADAMs in rheumatoid arthritis, Alzheimer\\'s disease, cardiac hypertrophy and asthma.

ADAMS - Introduction

International Nuclear Information System (INIS)

Song, Cheol Gi

2003-06-01

This book introduces ADAMS, which is composed of 20 modules ; stamping mechanism, ADAMS introduction, GUI overview failing stone project motion one DOF pendulum inclined plane lift mechanism I mechanism II mechanism III suspension subsystem suspension-steering system spring-damper I spring-damper II hatchback I hatchback II hatchback III cam-rocker-valve target practice recommended practice and switch mechanism workshop.

Safety evaluation report related to the operation of Grand Gulf Nuclear Station, Units 1 and 2. Dockets Nos. 50-416 and 50-417, Mississippi Power and Light Company; Middle South Energy, Inc., South Mississippi Electric Power Association

International Nuclear Information System (INIS)

1982-06-01

Supplement 2 to the Safety Evaluation Report for Mississippi Power and Light Company, et. al, joint application for licenses to operate the Grand Gulf Nuclear Station, Units 1 and 2, located on the east bank of the Mississippi River near Port Gibson, in Claiborne County, Mississippi, has been prepared by the Office of Nuclear Reactor Regulation of the US Nuclear Regulatory Commission. This supplement reports the status of certain items that had not been resolved at the time of publication of the Safety Evaluation Report

Using remotely sensed data and elementary analytical techniques in post-katrina mississippi to examine storm damage modeling

Science.gov (United States)

Curtis A. Collins; David L. Evans; Keith L. Belli; Patrick A. Glass

2010-01-01

Hurricane Katrina’s passage through south Mississippi on August 29, 2005, which damaged or destroyed thousands of hectares of forest land, was followed by massive salvage, cleanup, and assessment efforts. An initial assessment by the Mississippi Forestry Commission estimated that over $1 billion in raw wood material was downed by the storm, with county-level damage...

Ansel Adams: early works

Science.gov (United States)

Throckmorton, Jodi

2010-02-01

Ansel Adams (1902-1984), photographer, musician, naturalist, explorer, critic, and teacher, was a giant in the field of landscape photography. In his images of the unspoiled Western landscape, he strove to capture the sublime: the transcendentalist concept that nature can generate the experience of awe for the viewer. Many viewers are familiar with the heroic, high-contrast prints on high-gloss paper that Adams made to order beginning in the 1970s; much less well known are the intimate prints that the artist crafted earlier in his career. This exhibition focuses on these masterful small prints from the 1920s into the 1950s. During this time period, Adams's printing style changed dramatically. The painterly, soft-focus, warm-toned style of the Parmelian Prints of the High Sierras from the 1920s evolved into the sharp-focus style of the f/64 school of photography that Adams co-founded in the 1930s with Edward Weston and Imogen Cunningham. After World War II, Adams opted for a cooler, higher-contrast look for his prints. Throughout the various styles in which he chose to work, Adams explored the power of nature and succeeded in establishing landscape photography as a legitimate form of modern art.

Energy Density, Nutrient Adequacy, and Cost per Serving Can Provide Insight into Food Choices in the Lower Mississippi Delta

Science.gov (United States)

Connell, Carol L.; Zoellner, Jamie M.; Yadrick, M. Kathleen; Chekuri, Srinivasa C.; Crook, Lashaundrea B.; Bogle, Margaret L.

2012-01-01

Objective: To compare differences across food groups for food cost, energy, and nutrient profiles of 100 items from a cross-sectional survey of 225 stores in 18 counties across the Lower Mississippi Delta of Arkansas, Louisiana, and Mississippi. Methods: Energy, nutrient, and cost profiles for food items were calculated by using Naturally Nutrient…

Role of ADAMs in cancer formation and progression.

LENUS (Irish Health Repository)

Duffy, Michael J

2012-02-01

The ADAMs (a disintegrin and metalloproteinase) comprise a family of multidomain transmembrane and secreted proteins. One of their best-established roles is the release of biologically important ligands, such as tumor necrosis factor-alpha, epidermal growth factor, transforming growth factor-alpha, and amphiregulin. Because these ligands have been implicated in the formation and progression of tumors, it might be expected that the specific ADAMs involved in their release would also be involved in malignancy. Consistent with this hypothesis, emerging data from model systems suggest that ADAMs, such as ADAM-9, ADAM-12, ADAM-15, and ADAM-17, are causally involved in tumor formation\\/progression. In human cancer, specific ADAMs are up-regulated, with levels generally correlating with parameters of tumor progression and poor outcome. In preclinical models, selective ADAM inhibitors against ADAM-10 and ADAM-17 have been shown to synergize with existing therapies in decreasing tumor growth. The ADAMs are thus a new family of potential targets for the treatment of cancer, especially malignancies that are dependent on human epidermal growth factor receptor ligands or tumor necrosis factor-alpha.

ADAM 12 protease induces adipogenesis in transgenic mice

DEFF Research Database (Denmark)

Kawaguchi, Nobuko; Xu, Xiufeng; Tajima, Rie

2002-01-01

ADAM 12 (meltrin-alpha) is a member of the ADAM (a disintegrin and metalloprotease) family. ADAM 12 functions as an active metalloprotease, supports cell adhesion, and has been implicated in myoblast differentiation and fusion. Human ADAM 12 exists in two forms: the prototype membrane-anchored pr......ADAM 12 (meltrin-alpha) is a member of the ADAM (a disintegrin and metalloprotease) family. ADAM 12 functions as an active metalloprotease, supports cell adhesion, and has been implicated in myoblast differentiation and fusion. Human ADAM 12 exists in two forms: the prototype membrane......-anchored protein, ADAM 12-L, and a shorter secreted form, ADAM 12-S. Here we report the occurrence of adipocytes in the skeletal muscle of transgenic mice in which overexpression of either form is driven by the muscle creatine kinase promoter. Cells expressing a marker of early adipogenesis were apparent...

What's an Adam's Apple? (For Kids)

Science.gov (United States)

... for Educators Search English Español What's an Adam's Apple? KidsHealth / For Kids / What's an Adam's Apple? Print You're at the high school baseball ... the throat. This is what's called an Adam's apple. Everyone's larynx grows during puberty, but a girl's ...

Post-Closure Inspection, Sampling, and Maintenance Report for the Salmon, Mississippi, Site Calendar Year 2010

International Nuclear Information System (INIS)

2011-01-01

This report summarizes the annual inspection, sampling, measurement, and maintenance activities performed at the Salmon, Mississippi, Site in calendar year 2010. The draft Long-Term Surveillance and Maintenance Plan for the Salmon Site, Lamar County Mississippi (DOE 2007) specifies the submittal of an annual report of site activities with the results of sample analyses. The Salmon, MS, Site is a federally owned site located in Lamar County, MS, approximately 12 miles west of Purvis, MS, and about 21 miles southwest of Hattiesburg, MS (Figure 1). The U.S. Department of Energy (DOE), a successor agency to the U.S. Atomic Energy Commission (AEC), is responsible for the long-term surveillance and maintenance of the 1,470-acre site. DOE's Office of Legacy Management (LM) is the operating agent for the surface and subsurface real estate.

Internal architecture of the proximal femur--Adam's or Adams' arch? Historical mystery.

Science.gov (United States)

Bartonícek, J

2002-12-01

The designation 'Adam Bogen' describing the thick medial cortex of the femoral neck is an incorrect term. This arch was described by Robert Adams (1795-1871), an outstanding Irish anatomist and surgeon. He was famous mainly for his book on gout and the description of disorders of cardiac rhythm, the so-called Adams-Stokes syndrome. He published his original description in the today unfortunately almost forgotten Cyclopaedia of Anatomy and Physiology, Vol. II (London, Longman, 1836-1839). The main editor of this monumental six-volume work was the famous anatomist and surgeon R.B.Todd. This book represents a significant source of information on diseases and injuries of the great joints (shoulder, elbow, wrist, knee, ankle).

Effects of Career Education on 9th Graders in Rural Mississippi.

Science.gov (United States)

Sprabery, Carol A.; King, Jo Carol

This study evaluated a career education program for 141 ninth grade students at Kemper County High School in rural Mississippi in an effort to reduce the dropout rate and increase career awareness. A mental health counselor gave students monthly instruction on career issues necessary for vocational life after high school graduation. A local…

Addressing Breast Cancer Health Disparities in the Mississippi Delta Through an Innovative Partnership for Education, Detection, and Screening.

Science.gov (United States)

Mayfield-Johnson, Susan; Fastring, Danielle; Fortune, Melody; White-Johnson, Freddie

2016-06-01

Projects to reduce disparities in cancer treatment and research include collaborative partnerships and multiple strategies to promote community awareness, education, and engagement. This is especially needed in underserved areas such as the Mississippi Delta where more women are diagnosed at regional and distant stages of breast cancer. The purpose for this project was to increase the relatively low screening rate for African American women in the Mississippi Delta through a partnership between the Mississippi Network for Cancer Control and Prevention at The University of Southern Mississippi, The Fannie Lou Hamer Cancer Foundation and the Mississippi State Department of Health to decrease health disparities in breast cancer through increased awareness on self-early detection methods, leveraging resources to provide mammography screenings, and adequate follow-up with services and treatment for abnormal findings. Through this collaborative effort, over 500 women in three rural Mississippi Delta counties were identified, provided community education on early self-detection, and given appointments for mammography screenings within one fiscal year.

Statewide summary for Mississippi: Chapter H in Emergent wetlands status and trends in the northern Gulf of Mexico: 1950-2010

Science.gov (United States)

Handley, Larry; Spear, Kathryn A.; Leggett, Ali; Thatcher, Cindy A.

2012-01-01

The Mississippi coastline is 113 linear kilometers (70 miles) long and its estuaries cover approximately 594 km (369 mi; Figure 1) (Handley and others, 2007). It has a man-made sand beach 43.5 km (27 mi) long and 595.5 km (370 mi) of shoreline (Klein and others, b., 1998). The Mississippi Sound extends across the coastal waters of the State and encompasses 175,412 ha (433,443 acres). It is bordered by the Mississippi coast; Mobile Bay, Ala.; the Gulf Islands National Seashore barrier islands; and Lake Borgne, La. The watersheds and drainages feeding into Mississippi Sound, excluding tidal exchange from the Gulf of Mexico, include Lake Borgne, Pearl River, Jourdan River, Wolf River, Biloxi River, Tchoutacabouffa River, Pascagoula River, and Mobile Bay. The Pascagoula River is one of the last undammed rivers in the continental U.S. and the only undammed river flowing into the Gulf of Mexico. Freshwater inflow into Mississippi Sound, excluding that from Mobile Bay, averages 882.4 m3 per second (30,806 ft3 per second). The Mississippi coastal zone contains approximately one-third of the State’s 120 ecological communities (Klein and others, a., 1998). Regional land use includes silviculture, agriculture, and urban development, including several coastal casinos. Commercial shipping, shipbuilding, phosphate rock refinement, and electric power generation companies include some of the industrial complexes found along the Mississippi coast. The three counties found along the Mississippi coast, Hancock, Harrison, and Jackson Counties, had a total population of 370,702 as of 2010, constituting 12.5 percent of the State’s population (U.S. Census Bureau, 2010). These counties cover over 160.9 km (100 mi) of coastline and are one of the fastest growing regions in the state (Klein and others, b., 1998).The casino industry, military installations, trade, and manufacturing provide most jobs in coastal Mississippi. Two major deep-water ports exist in coastal Mississippi

Post-Closure Inspection, Sampling, and Maintenance Report for the Salmon, Mississippi, Site Calendar Year 2010

Energy Technology Data Exchange (ETDEWEB)

None

2011-03-01

This report summarizes the annual inspection, sampling, measurement, and maintenance activities performed at the Salmon, Mississippi, Site in calendar year 2010. The draft Long-Term Surveillance and Maintenance Plan for the Salmon Site, Lamar County Mississippi (DOE 2007) specifies the submittal of an annual report of site activities with the results of sample analyses. The Salmon, MS, Site is a federally owned site located in Lamar County, MS, approximately 12 miles west of Purvis, MS, and about 21 miles southwest of Hattiesburg, MS (Figure 1). The U.S. Department of Energy (DOE), a successor agency to the U.S. Atomic Energy Commission (AEC), is responsible for the long-term surveillance and maintenance of the 1,470-acre site. DOE's Office of Legacy Management (LM) is the operating agent for the surface and subsurface real estate.

The Hancock County Katrina Relief Initiative: Focusing Collaborative Leadership to Facilitate Recovery after a Natural Disaster

Science.gov (United States)

McNeese, Rose M.; Peters, Gary

2009-01-01

Eighteen months after Hurricane Katrina devastated the Mississippi coastal community of Hancock County on August 29, 2005, volunteers and organizations assisting with recovery in the area found chaos, confusion, and a desperate need for leadership. This qualitative study reflects the efforts of two University of Southern Mississippi professors as…

Preliminary data report of investigations conducted at the Salmon Site, Lamar County, Mississippi

International Nuclear Information System (INIS)

1994-04-01

The US Department of Energy (DOE) conducted ecological studies at the Salmon Site (SS), Lamar County, Mississippi, from the middle of June 1992 to the end of April 1993. The studies are part of the Remedial Investigation and Feasibility Study (RI/FS) being conducted by the DOE. The RI/FS is the methodology under the Comprehensive Environmental Response, Compensation, and Liability Act of 1980, as amended by the Superfund Amendments and Reauthorization Act of 1986 (CERCLA/SARA) for evaluating hazardous waste sites on the National Priorities List (NPL). The Salmon Site is not listed on the NPL but DOE has voluntarily elected to conduct the evaluation of the SS in accordance with CERCLA/SARA. As part of the remedial investigation, baseline human health and ecological risk assessments will be conducted. These baseline risk assessments will evaluate the potential impact on human health and the environment if remedial actions are not conducted, identify locations where additional information needs to be collected, help determine whether remedial actions are necessary, and provide justification for performing remedial actions. This report describes the sampling activities conducted between February and April 1993 to aid in evaluating the possible environmental impacts at the SS tailored to the specific circumstances and conditions found there. The initial investigations included identification of the flora and fauna in and around the SS, with particular emphasis on identifying sensitive environments, endangered species and their habitats, and those species consumed by humans or found in human food chains

Example evaluation of a permit application for a proposed hazardous-waste landfill in eastern Adams County, Colorado

Science.gov (United States)

Banta, E.R.

1986-01-01

A project was undertaken by the U.S. Geological Survey in cooperation with the U. S. Environmental Protection Agency to demonstrate methods by which RCRA (Resources Conservation and Recovery Act of 1976) Part B permit applications might be evaluated. The purpose of the project was to prepare a report that would supplement a series of case studies to be made available to permit writers in the U.S. Environmental Protection Agency. Four sites in the United States were chosen for their potential applicability to geologically similar sites. The Adams County, Colorado, site was chosen to be representative of sites in the Upper Cretaceous Pierre Shale. The intent of this report is to provide an example of how available earth-science information might be used in evaluating an application and not to evaluate the acceptability of the site. Because this study is an evaluation of a permit application, the data used are limited to the data supplied in the application and in published reports. Of the five criteria required by the U.S. Environmental Protection Agency to be addressed in the permit application considered in the case study, the application was evaluated to be inadequate in addressing three criteria: (1) Site characterization, (2) ability to monitor the location, and (3) flow paths and 100-foot time of travel. Details of the inadequacies and a description of the information needed to eliminate the inadequacies are included in the report. (USGS)

Lance-adams syndrome.

Science.gov (United States)

Shin, Jun-Hwa; Park, Jong Moon; Kim, A Ram; Shin, Hee Suk; Lee, Eun Shin; Oh, Min-Kyun; Yoon, Chul Ho

2012-08-01

It is not common for a patient who survives cardiac arrest to experience significant neurologic impairment such as acute and chronic post-hypoxic myoclonus, known as Lance-Adams syndrome. This syndrome is predominantly characterized by myoclonus that starts days to weeks after cardiopulmonary resuscitation in patients who regained consciousness. Although several cases of LAS were reported, the decisive treatment method has not been established. We report a 43 year old man with Lance-Adams syndrome who showed long-term improvement through treatment with anti-myoclonic agents and participation in a rehabilitation program.

Post-Closure Inspection, Sampling, and Maintenance Report for the Salmon, Mississippi, Site Calendar Year 2009

Energy Technology Data Exchange (ETDEWEB)

None

2010-10-01

This report summarizes the annual inspection, sampling, and maintenance activities performed on and near the Salmon, Mississippi, Site in calendar year 2009. The draft Long-Term Surveillance and Maintenance Plan for the Salmon Site, Lamar County, Mississippi (DOE 2007) specifies the submittal of an annual report of site activities and the results of sample analyses. This report complies with the annual report requirement. The Salmon, MS, Site is located in Lamar County, MS, approximately 12 miles west of Purvis, MS, and about 21 miles southwest of Hattiesburg, MS The site encompasses 1,470 acres and is not open to the general public. The U.S. Department of Energy (DOE), a successor agency to the U.S. Atomic Energy Commission (AEC), is responsible for the long-term surveillance and maintenance of the site. The DOE Office of Legacy Management (LM) was assigned responsibility for the site effective October 1, 2006

A new record of the Paleocene Carbon Isotope Maximum from the Mississippi Embayment

Science.gov (United States)

Platt, B. F.; Gerweck, E. D.

2017-12-01

The Paleocene-Eocene interval is well known as a time of climatic transitions, especially hyperthermals associated with disturbances in the carbon cycle that are used as proxies for impacts of projected anthropogenic global climate change. A recent roadcut in Benton County, Mississippi exposes a disconformity between the Paleocene Naheola Formation and the Eocene Meridian Sand. The disconformity is developed on a thick, kaolinitic paleosol, which we interpret as a mature Oxisol that supported tropical rainforest vegetation (as evidenced by associated well preserved leaf fossils). The nature of the paleosol at the disconformity led us to hypothesize that the strata might contain evidence of the Paleocene Eocene Thermal Maximum (PETM). We sampled two Mississippi Mineral Resources Institute (MMRI) cores from the equivalent stratigraphic interval from Benton and Tippah Counties, Mississippi, for bulk organic carbon stable isotopes at 25-cm intervals. Results showed no evidence of the negative excursion characteristic of the PETM. Instead, we found a gradual upsection enrichment that we interpret as the positive trend characteristic of the lower Paleocene Carbon Isotope Maximum (PCIM). This is reasonable based on published biostratigraphy and absolute ages from elsewhere in the Naheola Formation. Further analyses will be performed to determine whether the PCIM trend continues throughout the remainder of the core. The identification of the PCIM in Mississippi Embayment (ME) sediments is important because stable carbon isotope data may be useful for improving chronostratigraphy in the ME. Also, the PCIM is associated with a gradual warming trend as indicated by previously published stable oxygen isotopes from benthic foraminifera. Studying successive ME paleosols throughout the PCIM may yield information about the impacts of gradual atmospheric warming on soils and associated terrestrial systems.

Cultural Resources Intensive Survey and Testing of Mississippi River Levee Berms Crittenden and Desha Counties, Arkansas and Mississippi, Scott, Cape Girardeau and Pemiscot Counties, Missouri. Item R-846 Caruthersville, Pemiscot County, Missouri

Science.gov (United States)

1983-08-01

Houses of brick, stone and log were torn to pieces and those of frame tossed on their sides. Many citizens fled to the mountains . In 1812, the five...especially because of the many bands of guerrillas and Union troops who were ranging the countryside. No battles were fought in the projczt aLea ...to the economy of the state, were adamant about the need to build railroads. I 4-3 I Although one railroad, the St. Louis and Iron Mountain , ran from

John Adams and his times

International Nuclear Information System (INIS)

Amaldi, E.

1986-01-01

In this first John Adams' Memorial Lecture, an outline is given of his work, especially from the beginning of CERN in 1952 until his death in 1984. The historical survey covers John Adams' technical and managerial contributions to the development of CERN and its accelerators, as well as to fusion research in Britain and Europe. Exemplified by his role as member and president of the International Committee for Future Accelerators (ICFA), Adams' interest in international co-operation is also stressed. In the spirit of this great European, arguments are given for CERN to continue to be the first-rate high-energy physics laboratory which it has been in the past. (orig.)

Trees, Shrubs, and Woody Vines of the Bluff Experimental Forest, Warren County, Mississippi

Science.gov (United States)

Robert L. Johnson; Elbert L. Little

1967-01-01

Nearly 100 species of trees, shrubs, and woody vines grow naturally on the 450-acre Bluff Experimental Forest in west-central Mississippi. This publication lists the plants and provides information on silvical characteristics of the tree species.

ADAM9 Is a Novel Product of Polymorphonuclear Neutrophils

DEFF Research Database (Denmark)

Roychaudhuri, Robin; Hergrueter, Anja H; Polverino, Francesca

2014-01-01

A disintegrin and a metalloproteinase domain (ADAM) 9 is known to be expressed by monocytes and macrophages. In this study, we report that ADAM9 is also a product of human and murine polymorphonuclear neutrophils (PMNs). ADAM9 is not synthesized de novo by circulating PMNs. Rather, ADAM9 protein...

Activation of ADAM 12 protease by copper

DEFF Research Database (Denmark)

Loechel, F; Wewer, Ulla M.

2001-01-01

Conversion of latent proteases to the active form occurs by various mechanisms characteristic for different protease families. Here we report that the disintegrin metalloprotease ADAM 12-S is activated by Cu(II). Copper activation is distinct from the cysteine switch component of latency: elimina......Conversion of latent proteases to the active form occurs by various mechanisms characteristic for different protease families. Here we report that the disintegrin metalloprotease ADAM 12-S is activated by Cu(II). Copper activation is distinct from the cysteine switch component of latency......: elimination of the ADAM 12 cysteine switch by a point mutation in the propeptide had no effect on copper activation, whereas mutation of an unpaired cysteine residue in the catalytic domain resulted in a mutant form of ADAM 12-S that was insensitive to copper. This suggests a multi-step activation mechanism...... for ADAM 12 involving both furin cleavage and copper binding....

Adam Smith’s contribution to secularisation

Directory of Open Access Journals (Sweden)

Petrus Simons

2013-06-01

Full Text Available This article examined several crucial themes in Adam Smith’s philosophy with the purpose of highlighting and assessing his contribution to the secularisation of Western society. The article, written from the perspective of reformational philosophy, begins with a brief biography and sketch of Adam Smith’s influence on modern society, followed by a summary of Ponti Venter’s view on Smith. This sets the scene for a discussion of Adam Smith’s project, his method of tackling it, and his views on systems, philosophy of history and the concept of philosophy.

ADAM: Analyzer for Dialectal Arabic Morphology

Directory of Open Access Journals (Sweden)

Wael Salloum

2014-12-01

Full Text Available While Modern Standard Arabic (MSA has many resources, Arabic Dialects, the primarily spoken local varieties of Arabic, are quite impoverished in this regard. In this article, we present ADAM (Analyzer for Dialectal Arabic Morphology. ADAM is a poor man’s solution to quickly develop morphological analyzers for dialectal Arabic. ADAM has roughly half the out-of-vocabulary rate of a state-of-the-art MSA analyzer and is comparable in its recall performance to an Egyptian dialectal morphological analyzer that took years and expensive resources to build.

Connective tissue growth factor is a substrate of ADAM28

International Nuclear Information System (INIS)

Mochizuki, Satsuki; Tanaka, Rena; Shimoda, Masayuki; Onuma, Junko; Fujii, Yutaka; Jinno, Hiromitsu; Okada, Yasunori

2010-01-01

Research highlights: → The hyper-variable region in the cysteine-rich domain of ADAM28 binds to C-terminal domain of CTGF. → ADAM28 cleaves CTGF alone and CTGF in the CTGF/VEGF 165 complex. → CTGF digestion by ADAM28 releases biologically active VEGF 165 from the complex. → ADAM28, CTGF and VEGF 165 are commonly co-expressed by carcinoma cells in human breast carcinoma tissues. → These suggest that ADAM28 promotes VEGF 165 -induced angiogenesis in the breast carcinomas by selective CTGF digestion in the CTGF/VEGF 165 complex. -- Abstract: ADAM28, a member of the ADAM (a disintegrin and metalloproteinase) gene family, is over-expressed by carcinoma cells and the expression correlates with carcinoma cell proliferation and progression in human lung and breast carcinomas. However, information about substrates of ADAM28 is limited. We screened interacting molecules of ADAM28 in human lung cDNA library by yeast two-hybrid system and identified connective tissue growth factor (CTGF). Binding of CTGF to proADAM28 was demonstrated by yeast two-hybrid assay and protein binding assay. ADAM28 cleaved CTGF in dose- and time-dependent manners at the Ala 181 -Tyr 182 and Asp 191 -Pro 192 bonds in the hinge region of the molecule. ADAM28 selectively digested CTGF in the complex of CTGF and vascular endothelial growth factor 165 (VEGF 165 ), releasing biologically active VEGF 165 from the complex. RT-PCR and immunohistochemical analyses demonstrated that ADAM28, CTGF and VEGF are commonly co-expressed in the breast carcinoma tissues. These data provide the first evidence that CTGF is a novel substrate of ADAM28 and suggest that ADAM28 may promote VEGF 165 -induced angiogenesis in the breast carcinomas by the CTGF digestion in the CTGF/VEGF 165 complex.

ADAM-12 stability in first trimester maternal serum.

Science.gov (United States)

Cowans, N J; Stamatopoulou, A; Jaakohuhta, S; Spencer, K

2010-06-01

Maternal serum A Disintergrin And Metaloprotease-12 (ADAM-12) has been proposed as a marker for prenatal screening of chromosomal abnormalities, pre-eclampsia and other adverse pregnancy outcomes. In this study, we examine the stability of ADAM-12 with time and at different temperatures. Maternal serum and whole blood pools were stored at 30 degrees C, room temperature and refrigerator temperature or subjected to repeated freeze-thaw cycles. ADAM-12 was measured at set time points using an automated DELFIA research assay. Using a 10% change in concentration as a limit of stability, ADAM-12 is stable in serum for less than 15 h at 30 degrees C, less than 20 h at room temperature and for 51 h at refrigerator temperature. ADAM-12 levels are not altered following three - 20 degrees C to room temperature freeze-thaw cycles. The stability of ADAM-12 in whole blood appears similar to that in serum. The findings of this study suggest that ADAM-12 may be unstable under many routine laboratory conditions, and the marker's instability may also be partly responsible for the discrepancies in the literature.

Range extensions of three crayfishes (Faxonius yanahlindus, F. placidus, and F. erichsonianus) into Mississippi

Science.gov (United States)

Susan B. Adams; Robert L. Jones

2018-01-01

We report 3 new state crayfish records from the Tennessee River drainage in Tishomingo County, Mississippi: 1 is a re-identification of previously published material, and 2 are from unpublished collections. Faxonius yanahlindus (Spinywrist Crayfish), recently described from the middle Tennessee River drainage in northwest Alabama and southern...

ADAM (Affordable Desktop Application Manager): a Unix desktop application manager

International Nuclear Information System (INIS)

Liebana, M.; Marquina, M.; Ramos, R.

1996-01-01

ADAM stands for Affordable Desktop Application Manager. It is a GUI developed at CERN with the aim to ease access to applications. The motivation to develop ADAM came from the unavailability of environments like COSE/CDE and their heavy resource consumption. ADAM has proven to be user friendly: new users are able to customize it to their needs in few minutes. Groups of users may share through ADAM a common application environment. ADAM also integrates the Unix and the PC world. PC users can excess Unix applications in the same way as their usual Windows applications. This paper describes all the ADAM features, how they are used at CERN Public Services, and the future plans for ADAM. (author)

Ataxia and peripheral nerve hypomyelination in ADAM22-deficient mice

Directory of Open Access Journals (Sweden)

Ino Mitsuhiro

2005-05-01

Full Text Available Abstract Background ADAM22 is a member of the ADAM gene family, but the fact that it is expressed only in the nervous systems makes it unique. ADAM22's sequence similarity to other ADAMs suggests it to be an integrin binder and thus to have a role in cell-cell or cell-matrix interactions. To elucidate the physiological functions of ADAM22, we employed gene targeting to generate ADAM22 knockout mice. Results ADAM22-deficient mice were produced in a good accordance with the Mendelian ratio and appeared normal at birth. After one week, severe ataxia was observed, and all homozygotes died before weaning, probably due to convulsions. No major histological abnormalities were detected in the cerebral cortex or cerebellum of the homozygous mutants; however, marked hypomyelination of the peripheral nerves was observed. Conclusion The results of our study demonstrate that ADAM22 is closely involved in the correct functioning of the nervous system. Further analysis of ADAM22 will provide clues to understanding the mechanisms of human diseases such as epileptic seizures and peripheral neuropathy.

Baseline ecological risk assessment Salmon Site, Lamar County, Mississippi

International Nuclear Information System (INIS)

1995-04-01

The Salmon Site (SS), formerly the Tatum Dome Test Site, located in Mississippi was the site of two nuclear and two gas explosion tests conducted between 1964 and 1970. A consequence of these testing activities is that radionuclides were released into the salt dome, where they are presently contained. During reentry drilling and other site activities, incidental liquid and solid wastes that contained radioactivity were generated, resulting in some soil, ground water and equipment contamination. As part of the remedial investigation effort, a Baseline Ecological Risk Assessment was conducted at the SS. The purpose is to gauge ecological and other environmental impacts attributable to past activities at the former test facility. The results of this facility-specific baseline risk assessment are presented in this document

Baseline ecological risk assessment Salmon Site, Lamar County, Mississippi

Energy Technology Data Exchange (ETDEWEB)

NONE

1995-04-01

The Salmon Site (SS), formerly the Tatum Dome Test Site, located in Mississippi was the site of two nuclear and two gas explosion tests conducted between 1964 and 1970. A consequence of these testing activities is that radionuclides were released into the salt dome, where they are presently contained. During reentry drilling and other site activities, incidental liquid and solid wastes that contained radioactivity were generated, resulting in some soil, ground water and equipment contamination. As part of the remedial investigation effort, a Baseline Ecological Risk Assessment was conducted at the SS. The purpose is to gauge ecological and other environmental impacts attributable to past activities at the former test facility. The results of this facility-specific baseline risk assessment are presented in this document.

Cellular roles of ADAM12 in health and disease

DEFF Research Database (Denmark)

Kveiborg, Marie; Albrechtsen, Reidar; Couchman, John R

2008-01-01

and it is a potential biomarker for breast cancer. It is therefore important to understand ADAM12's functions. Many cellular roles for ADAM12 have been suggested. It is an active metalloprotease, and has been implicated in insulin-like growth factor (IGF) receptor signaling, through cleavage of IGF-binding proteins......, and in epidermal growth factor receptor (EGFR) pathways, via ectodomain shedding of membrane-tethered EGFR ligands. These proteolytic events may regulate diverse cellular responses, such as altered cell differentiation, proliferation, migration, and invasion. ADAM12 may also regulate cell-cell and cell...... to or from the cell interior. These ADAM12-mediated cellular effects appear to be critical events in both biological and pathological processes. This review presents current knowledge on ADAM12 functions gained from in vitro and in vivo observations, describes ADAM12's role in both normal physiology...

Reduction of the disintegrin and metalloprotease ADAM12 in preeclampsia

DEFF Research Database (Denmark)

Laigaard, Jennie; Sørensen, Tina; Placing, Sophie

2005-01-01

OBJECTIVES: The secreted form of ADAM12 is a metalloprotease that may be involved in placental and fetal growth. We examined whether the concentration of ADAM12 in first-trimester maternal serum could be used as a marker for preeclampsia. METHODS: We developed a semiautomated, time-resolved, immu......OBJECTIVES: The secreted form of ADAM12 is a metalloprotease that may be involved in placental and fetal growth. We examined whether the concentration of ADAM12 in first-trimester maternal serum could be used as a marker for preeclampsia. METHODS: We developed a semiautomated, time......-resolved, immunofluorometric assay for the quantification of ADAM12 in serum. The assay detected ADAM12 in a range of 78-1248 microg/L. Serum samples derived from women in the first trimester of a normal pregnancy (n = 324) and from women who later developed preeclampsia during pregnancy (n = 160) were obtained from the First...... Trimester Copenhagen Study. ADAM12 levels were assayed in these serum samples. Serum levels of ADAM12 were converted to multiples of the median (MoM) after log-linear regression of concentration versus gestational age. RESULTS: Serum ADAM12 levels in women who developed preeclampsia during pregnancy had...

ADAM15 expression is downregulated in melanoma metastasis compared to primary melanoma

International Nuclear Information System (INIS)

Ungerer, Christopher; Doberstein, Kai; Buerger, Claudia; Hardt, Katja; Boehncke, Wolf-Henning; Boehm, Beate; Pfeilschifter, Josef; Dummer, Reinhard; Mihic-Probst, Daniela; Gutwein, Paul

2010-01-01

Research highlights: → Strong ADAM15 expression is found in normal melanocytes. → ADAM15 expression is significantly downregulated in patients with melanoma metastasis. → TGF-β can downregulate ADAM15 expression in melanoma cells. → Overexpression of ADAM15 in melanoma cells inhibits migration, proliferation and invasion of melanoma cells. → Conclusion: ADAM15 represents an tumor suppressor protein in melanoma. -- Abstract: In a mouse melanoma metastasis model it has been recently shown that ADAM15 overexpression in melanoma cells significantly reduced the number of metastatic nodules on the lung. Unfortunately, the expression of ADAM15 in human melanoma tissue has not been determined so far. In our study, we characterized the expression of ADAM15 in tissue micro-arrays of patients with primary melanoma with melanoma metastasis. ADAM15 was expressed in melanocytes and endothelial cells of benign nevi and melanoma tissue. Importantly, ADAM15 was significantly downregulated in melanoma metastasis compared to primary melanoma. We further demonstrate that IFN-γ and TGF-β downregulate ADAM15 protein levels in melanoma cells. To investigate the role of ADAM15 in melanoma progression, we overexpressed ADAM15 in melanoma cells. Importantly, overexpression of ADAM15 in melanoma cells reduced the migration, invasion and the anchorage dependent and independent cell growth of melanoma cells. In summary, the downregulation of ADAM15 plays an important role in melanoma progression and ADAM15 act as a tumorsuppressor in melanoma.

ADAM15 expression is downregulated in melanoma metastasis compared to primary melanoma

Energy Technology Data Exchange (ETDEWEB)

Ungerer, Christopher; Doberstein, Kai [Pharmazentrum Frankfurt/ZAFES, University Hospital Goethe University Frankfurt, Frankfurt am Main (Germany); Buerger, Claudia; Hardt, Katja; Boehncke, Wolf-Henning [Department of Dermatology, Clinic of the Goethe-University, Theodor-Stern-Kai, Frankfurt (Germany); Boehm, Beate [Division of Rheumatology, Goethe University, Frankfurt am Main (Germany); Pfeilschifter, Josef [Pharmazentrum Frankfurt/ZAFES, University Hospital Goethe University Frankfurt, Frankfurt am Main (Germany); Dummer, Reinhard [Department of Pathology, Institute of Surgical Pathology, University Hospital, Zurich (Switzerland); Mihic-Probst, Daniela [Department of Dermatology, University Hospital Zurich (Switzerland); Gutwein, Paul, E-mail: p.gutwein@med.uni-frankfurt.de [Pharmazentrum Frankfurt/ZAFES, University Hospital Goethe University Frankfurt, Frankfurt am Main (Germany)

2010-10-22

Research highlights: {yields} Strong ADAM15 expression is found in normal melanocytes. {yields} ADAM15 expression is significantly downregulated in patients with melanoma metastasis. {yields} TGF-{beta} can downregulate ADAM15 expression in melanoma cells. {yields} Overexpression of ADAM15 in melanoma cells inhibits migration, proliferation and invasion of melanoma cells. {yields} Conclusion: ADAM15 represents an tumor suppressor protein in melanoma. -- Abstract: In a mouse melanoma metastasis model it has been recently shown that ADAM15 overexpression in melanoma cells significantly reduced the number of metastatic nodules on the lung. Unfortunately, the expression of ADAM15 in human melanoma tissue has not been determined so far. In our study, we characterized the expression of ADAM15 in tissue micro-arrays of patients with primary melanoma with melanoma metastasis. ADAM15 was expressed in melanocytes and endothelial cells of benign nevi and melanoma tissue. Importantly, ADAM15 was significantly downregulated in melanoma metastasis compared to primary melanoma. We further demonstrate that IFN-{gamma} and TGF-{beta} downregulate ADAM15 protein levels in melanoma cells. To investigate the role of ADAM15 in melanoma progression, we overexpressed ADAM15 in melanoma cells. Importantly, overexpression of ADAM15 in melanoma cells reduced the migration, invasion and the anchorage dependent and independent cell growth of melanoma cells. In summary, the downregulation of ADAM15 plays an important role in melanoma progression and ADAM15 act as a tumorsuppressor in melanoma.

Adam8 Limits the Development of Allergic Airway Inflammation in Mice

Science.gov (United States)

Knolle, Martin D.; Nakajima, Takahiro; Hergrueter, Anja; Gupta, Kushagra; Polverino, Francesca; Craig, Vanessa J.; Fyfe, Susanne E.; Zahid, Muhammad; Permaul, Perdita; Cernadas, Manuela; Montano, Gilbert; Tesfaigzi, Yohannes; Sholl, Lynette; Kobzik, Lester; Israel, Elliot; Owen, Caroline A.

2013-01-01

To determine whether a disintegrin and a metalloproteinase-8 (Adam8) regulates allergic airway inflammation (AAI) and airway hyper-responsiveness (AHR), we compared AAI and AHR in wild type (WT) versus Adam8−/− mice in different genetic backgrounds sensitized and challenged with ovalbumin (OVA) or house dust mite protein extract (HDM). OVA- and HDM-treated Adam8−/− mice had higher lung leukocyte counts, more airway mucus metaplasia, greater lung levels of some TH2 cytokines, and higher methacholine-induced increases in central airway resistance than allergen-treated WT mice. Studies of OVA-treated Adam8 bone marrow chimeric mice confirmed that leukocyte-derived Adam8 predominantly mediated Adam8’s anti-inflammatory activities in murine airways. Airway eosinophils and macrophages both expressed Adam8 in WT mice with AAI. Adam8 limited AAI and AHR in mice by reducing leukocyte survival because: 1) Adam8−/− mice with AAI had fewer apoptotic eosinophils and macrophages in their airways than WT mice with AAI; and 2) Adam8−/− macrophages and eosinophils had reduced rates of apoptosis compared with WT leukocytes when the intrinsic (but not the extrinsic) apoptosis pathway was triggered in the cells in vitro. ADAM8 was robustly expressed by airway granulocytes in lung sections from human asthma patients but, surprisingly, airway macrophages had less ADAM8 staining than airway eosinophils. Thus, ADAM8 has anti-inflammatory activities during AAI in mice by activating the intrinsic apoptosis pathway in myeloid leukocytes. Strategies that increase ADAM8 levels in myeloid leukocytes may have therapeutic efficacy in asthma. PMID:23670189

The ADAMs family of proteases: new biomarkers and therapeutic targets for cancer?

LENUS (Irish Health Repository)

Duffy, Michael J

2011-06-09

Abstract The ADAMs are transmembrane proteins implicated in proteolysis and cell adhesion. Forty gene members of the family have been identified, of which 21 are believed to be functional in humans. As proteases, their main substrates are the ectodomains of other transmembrane proteins. These substrates include precursor forms of growth factors, cytokines, growth factor receptors, cytokine receptors and several different types of adhesion molecules. Although altered expression of specific ADAMs has been implicated in different diseases, their best-documented role is in cancer formation and progression. ADAMs shown to play a role in cancer include ADAM9, ADAM10, ADAM12, ADAM15 and ADAM17. Two of the ADAMs, i.e., ADAM10 and 17 appear to promote cancer progression by releasing HER\\/EGFR ligands. The released ligands activate HER\\/EGFR signalling that culminates in increased cell proliferation, migration and survival. Consistent with a causative role in cancer, several ADAMs are emerging as potential cancer biomarkers for aiding cancer diagnosis and predicting patient outcome. Furthermore, a number of selective ADAM inhibitors, especially against ADAM10 and ADAM17, have been shown to have anti-cancer effects. At least one of these inhibitors is now undergoing clinical trials in patients with breast cancer.

The Metalloproteinase ADAM28 Promotes Metabolic Dysfunction in Mice

Directory of Open Access Journals (Sweden)

Lakshini Herat

2017-04-01

Full Text Available Obesity and diabetes are major causes of morbidity and mortality globally. The current study builds upon our previous association studies highlighting that A Disintegrin And Metalloproteinase 28 (ADAM28 appears to be implicated in the pathogenesis of obesity and type 2 diabetes in humans. Our novel study characterised the expression of ADAM28 in mice with the metabolic syndrome and used molecular inhibition approaches to investigate the functional role of ADAM28 in the pathogenesis of high fat diet-induced obesity. We identified that ADAM28 mRNA and protein expression was markedly increased in the livers of mice with the metabolic syndrome. In addition, noradrenaline, the major neurotransmitter of the sympathetic nervous system, results in elevated Adam28 mRNA expression in human monocytes. Downregulation of ADAM28 with siRNA technology resulted in a lack of weight gain, promotion of insulin sensitivity/glucose tolerance and decreased liver tumour necrosis factor-α (TNF-α levels in our diet-induced obesity mouse model as well as reduced blood urea nitrogen, alkaline phosphatase and aspartate aminotransferase. In addition, we show that ADAM28 knock-out mice also displayed reduced body weight, elevated high density lipoprotein cholesterol levels, and reductions in blood urea nitrogen, alkaline phosphatase, and aspartate aminotransferase. The results of this study provide important insights into the pathogenic role of the metalloproteinase ADAM28 in the metabolic syndrome and suggests that downregulation of ADAM28 may be a potential therapeutic strategy in the metabolic syndrome.

Human ADAM 12 (meltrin alpha) is an active metalloprotease

DEFF Research Database (Denmark)

Loechel, F; Gilpin, B J; Engvall, E

1998-01-01

The ADAMs (a disintegrin and metalloprotease) are a family of multidomain proteins with structural homology to snake venom metalloproteases. We recently described the cloning and sequencing of human ADAM 12 (meltrin alpha). In this report we provide evidence that the metalloprotease domain of ADAM...

ADAMS/WT advanced development - version 1.4 and beyond

Energy Technology Data Exchange (ETDEWEB)

Elliott, A.S.; Depauw, T.R. [Mechanical Dynamics, Inc., Mesa, AZ (United States)

1996-12-31

ADAMS/WT is an wind-turbine-specific shell for the general-purpose mechanical system simulation package ADAMS5. It was developed under the guidance of the National Renewable Energy Laboratory to give engineers and analysts in the wind turbine community access to the analytical power of ADAMS, without having to become expert in its particular technology. The 1.4 version of ADAMS/WT is the most recent upgrade to the package, incorporating the most up-to-date version of the AeroDyn aerodynamic forcing subroutines from the University of Utah. It is also the first version to be made available on the Windows/NT platform. In version 1.4, ADAMS/WT has been significantly improved throughout and runs much faster. Automatic generation of standardized output has been added. The documentation has been extensively augmented with more detailed descriptions, more figures and more examples. ADAMS/WT remains the most powerful analytical tool available for horizontal-axis wind turbine development. 10 figs.

Conservation and divergence of ADAM family proteins in the Xenopus genome

Directory of Open Access Journals (Sweden)

Shah Anoop

2010-07-01

Full Text Available Abstract Background Members of the disintegrin metalloproteinase (ADAM family play important roles in cellular and developmental processes through their functions as proteases and/or binding partners for other proteins. The amphibian Xenopus has long been used as a model for early vertebrate development, but genome-wide analyses for large gene families were not possible until the recent completion of the X. tropicalis genome sequence and the availability of large scale expression sequence tag (EST databases. In this study we carried out a systematic analysis of the X. tropicalis genome and uncovered several interesting features of ADAM genes in this species. Results Based on the X. tropicalis genome sequence and EST databases, we identified Xenopus orthologues of mammalian ADAMs and obtained full-length cDNA clones for these genes. The deduced protein sequences, synteny and exon-intron boundaries are conserved between most human and X. tropicalis orthologues. The alternative splicing patterns of certain Xenopus ADAM genes, such as adams 22 and 28, are similar to those of their mammalian orthologues. However, we were unable to identify an orthologue for ADAM7 or 8. The Xenopus orthologue of ADAM15, an active metalloproteinase in mammals, does not contain the conserved zinc-binding motif and is hence considered proteolytically inactive. We also found evidence for gain of ADAM genes in Xenopus as compared to other species. There is a homologue of ADAM10 in Xenopus that is missing in most mammals. Furthermore, a single scaffold of X. tropicalis genome contains four genes encoding ADAM28 homologues, suggesting genome duplication in this region. Conclusions Our genome-wide analysis of ADAM genes in X. tropicalis revealed both conservation and evolutionary divergence of these genes in this amphibian species. On the one hand, all ADAMs implicated in normal development and health in other species are conserved in X. tropicalis. On the other hand, some

Control of ADAM17 activity by regulation of its cellular localisation

Science.gov (United States)

Lorenzen, Inken; Lokau, Juliane; Korpys, Yvonne; Oldefest, Mirja; Flynn, Charlotte M.; Künzel, Ulrike; Garbers, Christoph; Freeman, Matthew; Grötzinger, Joachim; Düsterhöft, Stefan

2016-01-01

An important, irreversible step in many signalling pathways is the shedding of membrane-anchored proteins. A Disintegrin And Metalloproteinase (ADAM) 17 is one of the major sheddases involved in a variety of physiological and pathophysiological processes including regeneration, differentiation, and cancer progression. This central role in signalling implies that ADAM17 activity has to be tightly regulated, including at the level of localisation. Most mature ADAM17 is localised intracellularly, with only a small amount at the cell surface. We found that ADAM17 is constitutively internalised by clathrin-coated pits and that physiological stimulators such as GPCR ligands induce ADAM17-mediated shedding, but do not alter the cell-surface abundance of the protease. In contrast, the PKC-activating phorbol ester PMA, often used as a strong inducer of ADAM17, causes not only proteolysis by ADAM17 but also a rapid increase of the mature protease at the cell surface. This is followed by internalisation and subsequent degradation of the protease. Eventually, this leads to a substantial downregulation of mature ADAM17. Our results therefore imply that physiological activation of ADAM17 does not rely on its relocalisation, but that PMA-induced PKC activity drastically dysregulates the localisation of ADAM17. PMID:27731361

ADAM10 regulates Notch function in intestinal stem cells of mice.

Science.gov (United States)

Tsai, Yu-Hwai; VanDussen, Kelli L; Sawey, Eric T; Wade, Alex W; Kasper, Chelsea; Rakshit, Sabita; Bhatt, Riha G; Stoeck, Alex; Maillard, Ivan; Crawford, Howard C; Samuelson, Linda C; Dempsey, Peter J

2014-10-01

A disintegrin and metalloproteinase domain-containing protein 10 (ADAM10) is a cell surface sheddase that regulates physiologic processes, including Notch signaling. ADAM10 is expressed in all intestinal epithelial cell types, but the requirement for ADAM10 signaling in crypt homeostasis is not well defined. We analyzed intestinal tissues from mice with constitutive (Vil-Cre;Adam10(f/f) mice) and conditional (Vil-CreER;Adam10(f/f) and Leucine-rich repeat-containing GPCR5 [Lgr5]-CreER;Adam10(f/f) mice) deletion of ADAM10. We performed cell lineage-tracing experiments in mice that expressed a gain-of-function allele of Notch in the intestine (Rosa26(NICD)), or mice with intestine-specific disruption of Notch (Rosa26(DN-MAML)), to examine the effects of ADAM10 deletion on cell fate specification and intestinal stem cell maintenance. Loss of ADAM10 from developing and adult intestine caused lethality associated with altered intestinal morphology, reduced progenitor cell proliferation, and increased secretory cell differentiation. ADAM10 deletion led to the replacement of intestinal cell progenitors with 2 distinct, post-mitotic, secretory cell lineages: intermediate-like (Paneth/goblet) and enteroendocrine cells. Based on analysis of Rosa26(NICD) and Rosa26(DN-MAML) mice, we determined that ADAM10 controls these cell fate decisions by regulating Notch signaling. Cell lineage-tracing experiments showed that ADAM10 is required for survival of Lgr5(+) crypt-based columnar cells. Our findings indicate that Notch-activated stem cells have a competitive advantage for occupation of the stem cell niche. ADAM10 acts in a cell autonomous manner within the intestinal crypt compartment to regulate Notch signaling. This process is required for progenitor cell lineage specification and crypt-based columnar cell maintenance. Copyright © 2014 AGA Institute. Published by Elsevier Inc. All rights reserved.

Molecular profiling of ADAM12 in human bladder cancer

DEFF Research Database (Denmark)

Albrechtsen, Reidar; Dyrskjøt, Lars; Rudkjaer, Lise

2006-01-01

PURPOSE: We have previously found ADAM12, a disintegrin and metalloprotease, to be an interesting biomarker for breast cancer. The purpose of this study was to determine the gene and protein expression profiles of ADAM12 in different grades and stages of bladder cancer. EXPERIMENTAL DESIGN: ADAM12...... gene expression was evaluated in tumors from 96 patients with bladder cancer using a customized Affymetrix GeneChip. Gene expression in bladder cancer was validated using reverse transcription-PCR, quantitative PCR, and in situ hybridization. Protein expression was evaluated by immunohistochemical...... staining on tissue arrays of bladder cancers. The presence and relative amount of ADAM12 in the urine of cancer patients were determined by Western blotting and densitometric measurements, respectively. RESULTS: ADAM12 mRNA expression was significantly up-regulated in bladder cancer, as determined...

Potentiometric Surface in the Sparta-Memphis Aquifer of the Mississippi Embayment, Spring 2007

Science.gov (United States)

Schrader, T.P.

2008-01-01

The most widely used aquifer for industry and public supply in the Mississippi embayment in Arkansas, Louisiana, Mississippi, and Tennessee is the Sparta-Memphis aquifer. Decades of pumping from the Sparta-Memphis aquifer have affected ground-water levels throughout the Mississippi embayment. Regional assessments of water-level data from the aquifer are important to document regional water-level conditions and to develop a broad view of the effects of ground-water development and management on the sustainability and availability of the region's water supply. This information is useful to identify areas of water-level declines, identify cumulative areal declines that may cross State boundaries, evaluate the effectiveness of ground-water management strategies practiced in different States, and identify areas with substantial data gaps that may preclude effective management of ground-water resources. A ground-water flow model of the northern Mississippi embayment is being developed by the Mississippi Embayment Regional Aquifer Study (MERAS) to aid in answering questions about ground-water availability and sustainability. The MERAS study area covers parts of eight states including Alabama, Arkansas, Illinois, Kentucky, Louisiana, Mississippi, Missouri, and Tennessee and covers approximately 70,000 square miles. The U.S. Geological Survey (USGS) and the Mississippi Department of Environmental Quality Office of Land and Water Resources measured water levels in wells completed in the Sparta-Memphis aquifer in the spring of 2007 to assist in the MERAS model calibration and to document regional water-level conditions. Measurements by the USGS and the Mississippi Department of Environmental Quality Office of Land and Water Resources were done in cooperation with the Arkansas Natural Resources Commission; the Arkansas Geological Survey; Memphis Light, Gas and Water; Shelby County, Tennessee; and the city of Germantown, Tennessee. In 2005, total water use from the Sparta

Investigating the Impact of the Cisco 21st Century Schools Initiative on Harrison County School District. Summative Report

Science.gov (United States)

Ba, Harouna; Meade, Terri; Pierson, Elizabeth; Ferguson, Camille; Roy, Amanda; Williams, Hakim

2009-01-01

There are 21 schools in the Harrison County School District (HCSD), located in southern Mississippi, in the Gulfport/Biloxi metropolitan area. Of those, only Harrison Central 9th Grade (HC9) and Harrison County High School (HCHS) participated in the Cisco 21S Initiative--therefore, this summary will focus on only administrators, teachers,…

The shedding activity of ADAM17 is sequestered in lipid rafts

International Nuclear Information System (INIS)

Tellier, Edwige; Canault, Matthias; Rebsomen, Laure; Bonardo, Bernadette; Juhan-Vague, Irene; Nalbone, Gilles; Peiretti, Franck

2006-01-01

The tumor necrosis factor-alpha (TNF) converting enzyme (ADAM17) is a metalloprotease-disintegrin responsible for the cleavage of several biologically active transmembrane proteins. However, the substrate specificity of ADAM17 and the regulation of its shedding activity are still poorly understood. Here, we report that during its transport through the Golgi apparatus, ADAM17 is included in cholesterol-rich membrane microdomains (lipid rafts) where its prodomain is cleaved by furin. Consequently, ADAM17 shedding activity is sequestered in lipid rafts, which is confirmed by the fact that metalloproteinase inhibition increases the proportion of ADAM17 substrates (TNF and its receptors TNFR1 and TNFR2) in lipid rafts. Membrane cholesterol depletion increases the ADAM17-dependent shedding of these substrates demonstrating the importance of lipid rafts in the control of this process. Furthermore, ADAM17 substrates are present in different proportions in lipid rafts, suggesting that the entry of each of these substrates in these particular membrane microdomains is specifically regulated. Our data support the idea that one of the mechanisms regulating ADAM17 substrate cleavage involves protein partitioning in lipid rafts

Socioeconomic data base report for Mississippi

International Nuclear Information System (INIS)

1984-12-01

This report is published as a product of the Civilian Radioactive Waste Management Program. The objective of this program is to develop terminal waste storage facilities in deep, stable geologic formations for high-level nuclear wastes. Domed salt formations within the Gulf Coast Salt Dome Basin are among areas under consideration for repository sites. Within this region, the Richton Dome and Cypress Creek Dome in southeastern Mississippi are being evaluated as potential repository sites. This document presents socioeconomic baseline data for an eight-county area (50-mile radius) surrounding the Richton and Cypress Creek Dome sites and most likely to be affected by repository development. Information presented provides part of the technical basis upon which socioeconomic impacts can be assessed and repository sites selected, evaluated, and licensed

Distribution of the long-horned beetle, Dectes texanus, in soybeans of Missouri, Western Tennessee, Mississippi, and Arkansas.

Science.gov (United States)

Tindall, Kelly V; Stewart, Scott; Musser, Fred; Lorenz, Gus; Bailey, Wayne; House, Jeff; Henry, Robert; Hastings, Don; Wallace, Milus; Fothergill, Kent

2010-01-01

The long-horned beetle, Dectes texanus LeConte (Coleoptera: Cerambycidae), is a stem-boring pest of soybeans, Glycine max (L.) Merrill (Fabales: Fabaceae). Soybean stems and stubble were collected from 131 counties in Arkansas, Mississippi, Missouri, and Tennessee and dissected to determine D. texanus infestation rates. All states sampled had D. texanus present in soybeans. Data from Tennessee and Arkansas showed sample infestations of D. texanus averaging nearly 40%. Samples from Missouri revealed higher infestation in the twelve southeastern counties compared to the rest of the state. Data from Mississippi suggested that D. texanus is not as problematic there as in Arkansas, Missouri, and Tennessee. Infestation rates from individual fields varied greatly (0-100%) within states. In Tennessee, second crop soybeans (i.e. soybeans planted following winter wheat) had lower infestations than full season soybeans. A map of pest distribution is presented that documents the extent of the problem, provides a baseline from which changes can be measured, contributes data for emergency registration of pesticides for specific geographic regions, and provides useful information for extension personnel, crop scouts, and growers.

HISTORIA ECONÓMICA: El padre de la economia: Adam Smith

OpenAIRE

Accensi Martínez, Maria Cinta

2016-01-01

Peer-reviewed Artículo que describe una pequeña bibliografía del padre de la economía Adam Smith Article que descriu una petita bibliografia sobre el pare de l'economia Adam Smith. This article include a brief bibliography about Adam Smith.

Roles of ADAM13-regulated Wnt activity in early Xenopus eye development

Science.gov (United States)

Wei, Shuo; Xu, Guofeng; Bridges, Lance C.; Williams, Phoebe; Nakayama, Takuya; Shah, Anoop; Grainger, Robert M.; White, Judith M.; DeSimone, Douglas W.

2012-01-01

Pericellular proteolysis by ADAM family metalloproteinases has been widely implicated in cell signaling and development. We recently found that Xenopus ADAM13, an ADAM metalloproteinase, is required for activation of canonical Wnt signaling during cranial neural crest (CNC) induction by regulating a novel crosstalk between Wnt and ephrin B (EfnB) signaling pathways (Wei et al., 2010b). In the present study we show that the metalloproteinase activity of ADAM13 also plays important roles in eye development in X. tropicalis. Knockdown of ADAM13 results in reduced expression of eye field markers pax6 and rx1, as well as that of the pan-neural marker sox2. Activation of canonical Wnt signaling or inhibition of forward EfnB signaling rescues the eye defects caused by loss of ADAM13, suggesting that ADAM13 functions through regulation of the EfnB-Wnt pathway interaction. Downstream of Wnt, the head inducer Cerberus was identified as an effector that mediates ADAM13 function in early eye field formation. Furthermore, ectopic expression of the Wnt target gene snail2 restores cerberus expression and rescues the eye defects caused by ADAM13 knockdown. Together these data suggest an important role of ADAM13-regulated Wnt activity in eye development in Xenopus. PMID:22227340

Water-quality assessment of part of the upper Mississippi River basin, Minnesota and Wisconsin - Ground-water quality in an urban part of the Twin Cities Metropolitan area, Minnesota, 1996

Science.gov (United States)

Andrews, W.J.; Fong, A.L.; Harrod, Leigh; Dittes, M.E.

1998-01-01

In the spring of 1996, the Upper Mississippi River Basin Study Unit of the National Water-Quality Assessment Program drilled 30 shallow monitoring wells in a study area characterized by urban residential and commercial land uses. The monitoring wells were installed in sandy river-terrace deposits adjacent to the Mississippi River in Anoka and Hennepin Counties, Minnesota, in areas where urban development primarily occurred during the past 30 years.

Selective Modulation of Integrin-mediated Cell Migration by Distinct ADAM Family MembersV⃞

Science.gov (United States)

Huang, Jing; Bridges, Lance C.; White, Judith M.

2005-01-01

A disintegrin and a metalloprotease (ADAM) family members have been implicated in many biological processes. Although it is recognized that recombinant ADAM disintegrin domains can interact with integrins, little is known about ADAM-integrin interactions in cellular context. Here, we tested whether ADAMs can selectively regulate integrin-mediated cell migration. ADAMs were expressed in Chinese hamster ovary cells that express defined integrins (α4β1, α5β1, or both), and cell migration on full-length fibronectin or on its α4β1 or α5β1 binding fragments was studied. We found that ADAMs inhibit integrin-mediated cell migration in patterns dictated by the integrin binding profiles of their isolated disintegrin domains. ADAM12 inhibited cell migration mediated by the α4β1 but not the α5β1 integrin. ADAM17 had the reciprocal effect; it inhibited α5β1- but not α4β1-mediated cell migration. ADAM19 and ADAM33 inhibited migration mediated by both α4β1 and α5β1 integrins. A point mutation in the ADAM12 disintegrin loop partially reduced the inhibitory effect of ADAM12 on cell migration on the α4β1 binding fragment of fibronectin, whereas mutations that block metalloprotease activity had no effect. Our results indicate that distinct ADAMs can modulate cell migration mediated by specific integrins in a pattern dictated, at least in part, by their disintegrin domains. PMID:16079176

ADAM28 localizes to HLA-G+ trophoblasts and promotes column cell outgrowth.

Science.gov (United States)

De Luca, L C; Le, H T; Mara, D L; Beristain, A G

2017-07-01

Trophoblast progenitor cell differentiation towards the extravillous trophoblast (EVT) lineage initiates within proximal regions of anchoring columns of first trimester placental villi. While molecular processes controlling the initial stages of progenitor cell differentiation along the EVT pathway have been described, much remains unknown about factors important in distal column cell differentiation into invasive EVTs. ADAMs are proteases that regulate growth factor signaling, cell-matrix adhesion, and matrix proteolysis, and thus impact many processes relevant in placentation. Global gene expression studies identified the ADAM subtype, ADAM28, to be highly expressed in EVT-like trophoblasts, suggesting that it may play a role in EVT function. This study aims to test the functional importance of ADAM28 in column cell outgrowth and maintenance. ADAM28 mRNA levels and protein localization were determined by qPCR and immunofluorescence microscopy analyses in purified placental villi cell populations and tissues. ADAM28 function in trophoblast column outgrowth was examined using ADAM28-targetting siRNAs in Matrigel-imbedded placental explant cultures. Within placental villi, ADAM28 mRNA levels were highest in HLA-G + column trophoblasts, and consistent with this, ADAM28 was preferentially localized to HLA-G + trophoblasts within distal anchoring columns and decidual tissue. siRNA-directed loss of ADAM28 impaired trophoblast column outgrowth and resulted in increased apoptosis in matrix-invading trophoblasts. Our findings suggest that ADAM28 promotes column outgrowth by providing survival cues within anchoring column cells. This study also provides insight into a possible role for ADAM28 in driving differentiation of column trophoblasts into invasive HLA-G + EVT subsets. Copyright © 2017 Elsevier Ltd. All rights reserved.

Perceptions versus Realities: Exploring Needs and Science Learning Outcomes In the Mississippi Delta

Science.gov (United States)

Fitts, Lacey S.

The Mississippi Delta (MS Delta) is a high-poverty region in northwestern Mississippi located between the Mississippi and Yazoo rivers. The Delta is home to sixteen rural counties with over seventy failing or underperforming schools. Many of these schools lack the resources necessary to ensure adequate opportunities for all students. Learning outcomes for the state are among the lowest in the nation, and scores in the rural Delta are far below the state average. Graduating seniors take the ACT college entrance exam, with about 10% of Mississippi seniors scoring as "college-ready" in science. The region has a critical shortage of science teachers, and many schools do not offer advanced science courses. This study assessed teachers' needs, identified key characteristics of the secondary science programs in which they teach, and sought to understand conditions affecting science learning outcomes. An inventory of science teachers' needs was administered to teachers in the region. The greatest needs were material resources, high quality training, and strategies for improving poor reading and problem-solving skills of students. Of the factors examined, the percentage of students receiving free lunch had the strongest correlation with science learning outcomes in the school, higher than access to resources, number of science courses offered, and level of self-reported teacher need. A three-tiered approach to improving science learning outcomes has been developed, emphasizing community relationships, targeted professional development, and relevant science curriculum.

ADAMS executive and operating system

Science.gov (United States)

Pittman, W. D.

1981-01-01

The ADAMS Executive and Operating System, a multitasking environment under which a variety of data reduction, display and utility programs are executed, a system which provides a high level of isolation between programs allowing them to be developed and modified independently, is described. The Airborne Data Analysis/Monitor System (ADAMS) was developed to provide a real time data monitoring and analysis capability onboard Boeing commercial airplanes during flight testing. It inputs sensor data from an airplane performance data by applying transforms to the collected sensor data, and presents this data to test personnel via various display media. Current utilization and future development are addressed.

Alpha-Secretase ADAM10 Regulation: Insights into Alzheimer’s Disease Treatment

Science.gov (United States)

Peron, Rafaela; Vatanabe, Izabela Pereira; Manzine, Patricia Regina; Camins, Antoni

2018-01-01

ADAM (a disintegrin and metalloproteinase) is a family of widely expressed, transmembrane and secreted proteins of approximately 750 amino acids in length with functions in cell adhesion and proteolytic processing of the ectodomains of diverse cell-surface receptors and signaling molecules. ADAM10 is the main α-secretase that cleaves APP (amyloid precursor protein) in the non-amyloidogenic pathway inhibiting the formation of β-amyloid peptide, whose accumulation and aggregation leads to neuronal degeneration in Alzheimer’s disease (AD). ADAM10 is a membrane-anchored metalloprotease that sheds, besides APP, the ectodomain of a large variety of cell-surface proteins including cytokines, adhesion molecules and notch. APP cleavage by ADAM10 results in the production of an APP-derived fragment, sAPPα, which is neuroprotective. As increased ADAM10 activity protects the brain from β-amyloid deposition in AD, this strategy has been proved to be effective in treating neurodegenerative diseases, including AD. Here, we describe the physiological mechanisms regulating ADAM10 expression at different levels, aiming to propose strategies for AD treatment. We report in this review on the physiological regulation of ADAM10 at the transcriptional level, by epigenetic factors, miRNAs and/or translational and post-translational levels. In addition, we describe the conditions that can change ADAM10 expression in vitro and in vivo, and discuss how this knowledge may help in AD treatment. Regulation of ADAM10 is achieved by multiple mechanisms that include transcriptional, translational and post-translational strategies, which we will summarize in this review. PMID:29382156

Catalytic properties of ADAM12 and its domain deletion mutants

DEFF Research Database (Denmark)

Jacobsen, Jonas; Visse, Robert; Sørensen, Hans Peter

2008-01-01

of pro, catalytic, disintegrin, cysteine-rich, and EGF domains. Here we present a novel activity of recombinant ADAM12-S and its domain deletion mutants on S-carboxymethylated transferrin (Cm-Tf). Cleavage of Cm-Tf occurred at multiple sites, and N-terminal sequencing showed that the enzyme exhibits...... restricted specificity but a consensus sequence could not be defined as its subsite requirements are promiscuous. Kinetic analysis revealed that the noncatalytic C-terminal domains are important regulators of Cm-Tf activity and that ADAM12-PC consisting of the pro domain and catalytic domain is the most...... active on this substrate. It was also observed that NaCl inhibits ADAM12. Among the tissue inhibitors of metalloproteinases (TIMP) examined, the N-terminal domain of TIMP-3 (N-TIMP-3) inhibits ADAM12-S and ADAM12-PC with low nanomolar Ki(app) values while TIMP-2 inhibits them with a slightly lower...

The roles of ADAM33, ADAM28, IL-13 and IL-4 in the development of lung injuries in children with lethal non-pandemic acute infectious pneumonia.

Science.gov (United States)

Baurakiades, Emanuele; Costa, Victor Horácio; Raboni, Sonia Mara; de Almeida, Vivian Rafaela Telli; Larsen, Kelly Susana Kunze; Kohler, Juliana Nemetz; Gozzo, Priscilla do Carmo; Klassen, Giseli; Manica, Graciele C M; de Noronha, Lucia

2014-12-01

ADAM28, ADAM33, IL-13, IL-4 and other cytokines (IL-6 and IL-10) seem to play important roles in the persistence and maintenance of acute inflammatory processes that ultimately lead to lung remodeling and pulmonary fibrosis, which may be responsible for the high morbidity and mortality rates associated with non-pandemic acute viral pneumonias in childhood. The aim of this study was to evaluate the roles of ADAM33, ADAM28, IL4, IL6, IL10 and IL13 in the development of inflammation and alveolar fibrosis due to lethal acute respiratory infections of the lower airway in a pediatric population, especially in those with viral etiology. For this study, 193 cases were selected, and samples from the cases were processed for viral antigen detection by immunohistochemistry and then separated into two groups: virus-positive (n=68) and virus-negative (n=125). Immunohistochemistry was performed to assess the presence of metalloproteinases (ADAM33 and ADAM28) and inflammatory cytokines (IL-4, IL-13, IL-6, IL-10) in the alveolar septa. The virus-positive group showed stronger immunolabeling for ADAM33, ADAM28, IL-4 and IL-13 (pplay important roles in pulmonary inflammatory reactions elicited against etiological viral agents. In addition, these mediators may affect the process of lung remodeling and the development of pulmonary fibrosis. Copyright © 2014 Elsevier B.V. All rights reserved.

Trafficking of human ADAM 12-L: retention in the trans-Golgi network

DEFF Research Database (Denmark)

Hougaard, S; Loechel, F; Xu, X

2000-01-01

We have investigated the trafficking of the membrane-anchored form of human ADAM 12 (ADAM 12-L) fused to a green fluorescence protein tag. Subcellular localization of the protein in transiently transfected cells was determined by fluorescence microscopy and trypsin sensitivity. Full-length ADAM 12...... the cytoplasmic and transmembrane domains, but not the Src homology 3 domain (SH3) binding sites. These results raise the possibility that a trafficking checkpoint in the trans-Golgi network is one of the cellular mechanisms for regulation of ADAM 12-L function, by allowing a rapid release of ADAM 12-L...

ADAM12 produced by tumor cells rather than stromal cells accelerates breast tumor progression

DEFF Research Database (Denmark)

Frohlich, Camilla; Nehammer, Camilla; Albrechtsen, Reidar

2011-01-01

that ADAM12 deficiency reduces breast tumor progression in the PyMT model. However, the catalytic activity of ADAM12 appears to be dispensable for its tumor-promoting effect. Interestingly, we demonstrate that ADAM12 endogenously expressed in tumor-associated stroma in the PyMT model does not influence......Expression of ADAM12 is low in most normal tissues, but is markedly increased in numerous human cancers, including breast carcinomas. We have previously shown that overexpression of ADAM12 accelerates tumor progression in a mouse model of breast cancer (PyMT). In the present study, we found...... hypothesized, however, that the tumor-associated stroma may stimulate ADAM12 expression in tumor cells, based on the fact that TGF-ß1 stimulates ADAM12 expression and is a well-known growth factor released from tumor-associated stroma. TGF-ß1 stimulation of ADAM12-negative Lewis lung tumor cells induced ADAM12...

Molecular profiling of ADAM12 in human bladder cancer

DEFF Research Database (Denmark)

Albrechtsen, Reidar; Dyrskjøt, Lars; Rudkjaer, Lise

2006-01-01

PURPOSE: We have previously found ADAM12, a disintegrin and metalloprotease, to be an interesting biomarker for breast cancer. The purpose of this study was to determine the gene and protein expression profiles of ADAM12 in different grades and stages of bladder cancer. EXPERIMENTAL DESIGN: ADAM12...... gene expression was evaluated in tumors from 96 patients with bladder cancer using a customized Affymetrix GeneChip. Gene expression in bladder cancer was validated using reverse transcription-PCR, quantitative PCR, and in situ hybridization. Protein expression was evaluated by immunohistochemical...

Operation of Grand Gulf Nuclear Station, Units 1 and 2, Dockets Nos. 50-416 and 50-417: Mississippi Power and Light Company, Middle South Energy, Inc., South Mississippi Electric Power Association. Final environmental statement

International Nuclear Information System (INIS)

1981-09-01

The information in this Final Environmental Statement is the second assessment of the environmental impacts associated with the construction and operation of the Grand Gulf Nuclear Station, Units 1 and 2, located on the Mississippi River in Claiborne County, Mississippi. The Draft Environmental Statement was issued in May 1981. The first assessment was the Final Environmental Statement related to construction, which was issued in August 1973 prior to issuance of the Grand Gulf Nuclear Station construction permits. In September 1981 Grand Gulf Unit 1 was 92% complete and Unit 2 was 22% complete. Fuel loading for Unit 1 is scheduled for December 1981. The present assessment is the result of the NRC staff review of the activities associated with the proposed operation of the Station, and includes the staff responses to comments on the Draft Environmental Statement

ADAM10 is essential for cranial neural crest-derived maxillofacial bone development

Energy Technology Data Exchange (ETDEWEB)

Tan, Yu, E-mail: tanyu2048@163.com; Fu, Runqing, E-mail: furunqing@sjtu.edu.cn; Liu, Jiaqiang, E-mail: liujqmj@163.com; Wu, Yong, E-mail: wyonger@gmail.com; Wang, Bo, E-mail: wb228@126.com; Jiang, Ning, E-mail: 179639060@qq.com; Nie, Ping, E-mail: nieping1011@sina.com; Cao, Haifeng, E-mail: 0412chf@163.com; Yang, Zhi, E-mail: wcums1981@163.com; Fang, Bing, E-mail: fangbing@sjtu.edu.cn

2016-07-08

Growth disorders of the craniofacial bones may lead to craniofacial deformities. The majority of maxillofacial bones are derived from cranial neural crest cells via intramembranous bone formation. Any interruption of the craniofacial skeleton development process might lead to craniofacial malformation. A disintegrin and metalloprotease (ADAM)10 plays an essential role in organ development and tissue integrity in different organs. However, little is known about its function in craniofacial bone formation. Therefore, we investigated the role of ADAM10 in the developing craniofacial skeleton, particularly during typical mandibular bone development. First, we showed that ADAM10 was expressed in a specific area of the craniofacial bone and that the expression pattern dynamically changed during normal mouse craniofacial development. Then, we crossed wnt1-cre transgenic mice with adam10-flox mice to generate ADAM10 conditional knockout mice. The stereomicroscopic, radiographic, and von Kossa staining results showed that conditional knockout of ADAM10 in cranial neural crest cells led to embryonic death, craniofacial dysmorphia and bone defects. Furthermore, we demonstrated that impaired mineralization could be triggered by decreased osteoblast differentiation, increased cell death. Overall, these findings show that ADAM10 plays an essential role in craniofacial bone development. -- Highlights: •We firstly reported that ADAM10 was essentially involved in maxillofacial bone development. •ADAM10 cKO mice present craniofacial dysmorphia and bone defects. •Impaired osteoblast differentiation,proliferation and apoptosis underlie the bone deformity.

ADAM10 is essential for cranial neural crest-derived maxillofacial bone development

International Nuclear Information System (INIS)

Tan, Yu; Fu, Runqing; Liu, Jiaqiang; Wu, Yong; Wang, Bo; Jiang, Ning; Nie, Ping; Cao, Haifeng; Yang, Zhi; Fang, Bing

2016-01-01

Growth disorders of the craniofacial bones may lead to craniofacial deformities. The majority of maxillofacial bones are derived from cranial neural crest cells via intramembranous bone formation. Any interruption of the craniofacial skeleton development process might lead to craniofacial malformation. A disintegrin and metalloprotease (ADAM)10 plays an essential role in organ development and tissue integrity in different organs. However, little is known about its function in craniofacial bone formation. Therefore, we investigated the role of ADAM10 in the developing craniofacial skeleton, particularly during typical mandibular bone development. First, we showed that ADAM10 was expressed in a specific area of the craniofacial bone and that the expression pattern dynamically changed during normal mouse craniofacial development. Then, we crossed wnt1-cre transgenic mice with adam10-flox mice to generate ADAM10 conditional knockout mice. The stereomicroscopic, radiographic, and von Kossa staining results showed that conditional knockout of ADAM10 in cranial neural crest cells led to embryonic death, craniofacial dysmorphia and bone defects. Furthermore, we demonstrated that impaired mineralization could be triggered by decreased osteoblast differentiation, increased cell death. Overall, these findings show that ADAM10 plays an essential role in craniofacial bone development. -- Highlights: •We firstly reported that ADAM10 was essentially involved in maxillofacial bone development. •ADAM10 cKO mice present craniofacial dysmorphia and bone defects. •Impaired osteoblast differentiation,proliferation and apoptosis underlie the bone deformity.

ADAM 12 cleaves extracellular matrix proteins and correlates with cancer status and stage

DEFF Research Database (Denmark)

Roy, Roopali; Wewer, Ulla M; Zurakowski, David

2004-01-01

-Sepharose affinity chromatography followed by protein identification by matrix-assisted laser desorption/ionization-time of flight mass spectrometry. Four peptides were identified that spanned the amino acid sequence of ADAM 12. Immunoblot analysis using ADAM 12-specific antibodies detected an approximately 68-k......Da band identified as the mature form of ADAM 12. To characterize catalytic properties of ADAM 12, full-length ADAM 12-S was expressed in COS-7 cells and purified. Substrate specificity studies demonstrated that ADAM 12-S degrades gelatin, type IV collagen, and fibronectin but not type I collagen...... or casein. Gelatinase activity of ADAM 12 was completely abrogated by zinc chelators 1,10-phenanthroline and EDTA and was partially inhibited by the hydroxamate inhibitor Marimastat. Endogenous matrix metalloprotease inhibitor TIMP-3 inhibited activity. To validate our initial identification of this enzyme...

The Joseph Barker, Jr. Home: A Comparative Architectural and Historical Study of a 19th Century Brick and Frame Dwelling in Washington County, Ohio,

Science.gov (United States)

1981-02-01

anti-slavery debates of 1836 (Williams 1881: 430) and was deeply involved in Washington County politics. At the arrival of John Quincy Adams during a...433) continued with Adams up the Ohio River as far as Pittsburgh. Barker was a frequent participant in political discussions at the store 29 of... Ansel Wood and ca. 1819 by Timothy Love. Patton (1936: 30), on the other hand, dated the construction to ca. 1832-1836 and stated that it was built

FlipADAM: a potential new SPECT imaging agent for the serotonin transporter

Energy Technology Data Exchange (ETDEWEB)

Wang, Julie L.; Deutsch, Eric C. [Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 (United States); Oya, Shunichi [Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 (United States); Kung, Hank F., E-mail: kunghf@gmail.co [Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 (United States); Department of Radiology, University of Pennsylvania School of Medicine, Philadelphia, PA 19104 (United States)

2010-07-15

Introduction: Single photon emission computed tomography (SPECT) imaging of the serotonin transporter (SERT) in the brain is a useful tool for examining normal physiological functions and disease states involving the serotonergic system. The goal of this study was to develop an improved SPECT radiotracer with faster kinetics than the current leading SPECT tracer, [{sup 123}I]ADAM, for selective SERT imaging. Methods: The in vitro binding affinities of (2-(2'-((dimethylamino)methyl)-4'-iodophenylthio)benzenamine) (FlipADAM) (1c), were determined using Hampshire pig kidney cells stably overexpressing the serotonin, norepinephrine (NET) or dopamine transporter (DAT). Localization of [{sup 125}I]FlipADAM (1c) was evaluated through biodistribution and autoradiography in male Sprague Dawley rats, and the specificity of binding was assessed by injecting selective SERT or NET inhibitors prior to [{sup 125}I]FlipADAM (1c). Results: FlipADAM (1c) displayed a high binding affinity for SERT (K{sub i}=1.0 nM) and good selectivity over NET and DAT binding (43-fold and 257-fold, respectively). [{sup 125}I]FlipADAM (1c) successfully penetrated the blood brain barrier, as evidenced by the brain uptake at 2 min (1.75% dose/g). [{sup 125}I]FlipADAM(1c) also had a good target to non-target (hypothalamus/cerebellum) ratio of 3.35 at 60 min post-injection. In autoradiography studies, [{sup 125}I]FlipADAM (1c) showed selective localization in SERT-rich brain regions such as the thalamic nuclei, amygdala, dorsal raphe nuclei and other areas. Conclusion: [{sup 125}I]FlipADAM (1c) exhibited faster clearance from the brain and time to binding equilibrium when compared to [{sup 125}I]2-(2'-((dimethylamino)methyl)-phenylthio)-5-iodophenylamine [{sup 125}I]ADAM (1b) and a higher target to non-target ratio when compared to [{sup 125}I]5-iodo-2-(2'-((dimethylamino)methyl)-phenylthio)benzyl alcohol [{sup 125}I]IDAM (1a). Therefore, [{sup 123}I]FlipADAM (1c) may be an improved

Roles of ADAM13-regulated Wnt activity in early Xenopus eye development

OpenAIRE

Wei, Shuo; Xu, Guofeng; Bridges, Lance C.; Williams, Phoebe; Nakayama, Takuya; Shah, Anoop; Grainger, Robert M.; White, Judith M.; DeSimone, Douglas W.

2011-01-01

Pericellular proteolysis by ADAM family metalloproteinases has been widely implicated in cell signaling and development. We recently found that Xenopus ADAM13, an ADAM metalloproteinase, is required for activation of canonical Wnt signaling during cranial neural crest (CNC) induction by regulating a novel crosstalk between Wnt and ephrin B (EfnB) signaling pathways (Wei et al., 2010b). In the present study we show that the metalloproteinase activity of ADAM13 also plays important roles in eye...

Lance-Adams Syndrome in the Pretargeted Temperature Management Era.

Science.gov (United States)

Freund, Brin; Sutter, Raoul; Kaplan, Peter W

2017-03-01

Acute posthypoxic myoclonus portends a poor prognosis. Another form of posthypoxic myoclonus, Lance-Adams syndrome, is associated with a better outcome. Differentiating these two entities is important in prognostication and guiding further medical intervention. This can be difficult in the acute setting after hypoxic brain injury but the use of neurophysiologic studies may be helpful. In this article, we present a case of a patient who presented after pulseless electrical activity arrest, underwent targeted temperature management and subsequently developed Lance-Adams syndrome. The neurologic and electroencephalographic findings in Lance-Adams syndrome are discussed with an updated review.

A brief critique of the Adam-Gibbs entropy model

DEFF Research Database (Denmark)

Dyre, J. C.; Hecksher, Tina; Niss, Kristine

2009-01-01

This paper critically discusses the entropy model proposed by Adam and Gibbs in 1965 for the dramatic temperature dependence of glass-forming liquids' average relaxation time, which is one of the most influential models during the last four decades. We discuss the Adam-Gibbs model's theoretical...

Harald Velner - insener üle poole sajandi / Harald-Adam Velner

Index Scriptorium Estoniae

Velner, Harald-Adam, 1923-2012

2008-01-01

Harald-Adam Velner on Eesti Inseneride Liidu esimene taasiseseisvumisjärgne president. Lisaks Liis Seili lühiartikkel Harald-Adam Velneri isast August Velnerist: Teedeinsenerist isa juhtis inseneride ühendust enne sõda

ADAM12-S stimulates bone growth in transgenic mice by modulating chondrocyte proliferation and maturation

DEFF Research Database (Denmark)

Kveiborg, Marie; Albrechtsen, Reidar; Rudkjaer, Lise

2006-01-01

ADAM12-S transgenic mice exhibit a pronounced increase in the length of bones, such as femur, tibia, and vertebrae. The effect of ADAM12-S on longitudinal bone growth involves the modulation of chondrocyte proliferation and maturation, likely through proteolytic activities and altered cell......: Transgenic mice expressing the secreted form of human ADAM12, ADAM12-S, or a truncated metalloprotease-deficient form of ADAM12-S in the circulation were used to study the effects of ADAM12 on the skeleton. In addition, murine chondrocyte cultures were used to study the effect of ADAM12-S on cell...... studies showed that ADAM12-S inhibits chondrocyte adhesion to fibronectin and collagen type II. CONCLUSIONS: ADAM12-S stimulates bone growth in mice by modulating chondrocyte proliferation and maturation through mechanisms probably involving both metalloprotease and adhesion activities....

Taking Charge: Walter Sydney Adams and the Mount Wilson Observatory

Science.gov (United States)

Brashear, R.

2004-12-01

The growing preeminence of American observational astronomy in the first half of the 20th century is a well-known story and much credit is given to George Ellery Hale and his skill as an observatory-building entrepreneur. But a key figure who has yet to be discussed in great detail is Walter Sydney Adams (1876-1956), Hale's Assistant Director at Mount Wilson Observatory. Due to Hale's illnesses, Adams was Acting Director for much of Hale's tenure, and he became the second Director of Mount Wilson from 1923 to 1946. Behind his New England reserve Adams was instrumental in the growth of Mount Wilson and thus American astronomy in general. Adams was hand-picked by Hale to take charge of stellar spectroscopy work at Yerkes and Mount Wilson and the younger astronomer showed tremendous loyalty to Hale and Hale's vision throughout his career. As Adams assumed the leadership role at Mount Wilson he concentrated on making the observatory a place where researchers worked with great freedom but maintain a high level of cooperation. This paper will concentrate on Adams's early years and look at his growing relationship with Hale and how he came to be the central figure in the early history of Mount Wilson as both a solar and stellar observatory. His education, his years at Dartmouth and Yerkes (including his unfortunate encounter with epsilon Leonis), and his formative years on Mount Wilson are all important in learning how he shaped the direction of Mount Wilson and the development of American astronomy in the first half of the 20th century. This latter history cannot be complete until we bring Adams into better focus.

ADAM-17 regulates endothelial cell morphology, proliferation, and in vitro angiogenesis

International Nuclear Information System (INIS)

Goeoz, Pal; Goeoz, Monika; Baldys, Aleksander; Hoffman, Stanley

2009-01-01

Modulation of angiogenesis is a promising approach for treating a wide variety of human diseases including ischemic heart disease and cancer. In this study, we show that ADAM-17 is an important regulator of several key steps during angiogenesis. Knocking down ADAM-17 expression using lentivirus-delivered siRNA in HUVECs inhibited cell proliferation and the ability of cells to form close contact in two-dimensional cultures. Similarly, ADAM-17 depletion inhibited the ability of HUVECs to form capillary-like networks on top of three-dimensional Matrigel as well as in co-culture with fibroblasts within a three-dimensional scaffold. In mechanistic studies, both baseline and VEGF-induced MMP-2 activation and Matrigel invasion were inhibited by ADAM-17 depletion. Based on our findings we propose that ADAM-17 is part of a novel pro-angiogenic pathway leading to MMP-2 activation and vessel formation.

John Adams's Montesquieuean Moment: Enlightened Historicism in the Discourses on Davila.

Science.gov (United States)

Green, Jonathan

2016-01-01

At the outset of the French Revolution John Adams penned a series of Discourses of Davila, philosophical ruminations on the sixteenth-century French Wars of Religion. Recent historians have read these Discourses in terms of Adams's Machiavellianism-his conviction that men's passions lead to violence, if unrestrained. But this reading overlooks the extent to which Adams intended his Discourses as a particular investigation into the French nation's character, and into whether the revolutionaries could lay claim to a native, French tradition of mixed constitutional government. Situating the Discourses vis-à-vis Adams's contemporaneous reading of Montesquieu, this article argues for an underappreciated historicist dimension to his thought.

Adam Smith, Market and Social Change

DEFF Research Database (Denmark)

Bouchet, Dominique

2017-01-01

Adam Smith (1723-1790) provided us with a remarkable synthesis of the economic and political ideas of his time and developed a conceptual system to analyse social interactions that mattered for the wealth of nations. He proposed a radically different roadmap for the future development of the soci......Adam Smith (1723-1790) provided us with a remarkable synthesis of the economic and political ideas of his time and developed a conceptual system to analyse social interactions that mattered for the wealth of nations. He proposed a radically different roadmap for the future development...... of the society he lived in. The fact that his original analyses were rooted in a given historical context and were founded on a well thought-through conceptual system should not be ignored. The galvanising effect of the dribs and drabs of Adam Smith ideas that have been bandied about are a long way from...... the powerful insights imbued in the original ideas. Putting those back into context, looking into how Smith proceeded then, trying to update his observations, might help us to be more attentive to the market changes and social challenges of our times....

Transgenic overexpression of ADAM12 suppresses muscle regeneration and aggravates dystrophy in aged mdx mice

DEFF Research Database (Denmark)

Jørgensen, Louise Helskov; Jensen, Charlotte Harken; Wewer, Ulla M

2007-01-01

mice (ADAM12(+)) after a knife cut lesion and observed that the regeneration process was significantly impaired. ADAM12 seemed to inhibit the satellite cell response and delay myoblast differentiation. These results discourage long-term therapeutic use of ADAM12. They also point to impaired...... effect of ADAM12 was suggested to be mediated via a membrane-stabilizing up-regulation of utrophin, alpha7B integrin, and dystroglycans. Ectopic ADAM12 expression in normal mouse skeletal muscle also improved regeneration after freeze injury, presumably by the same mechanism. Hence, it was suggested...... overexpressing ADAM12 (ADAM12(+)/mdx mice), even though their utrophin levels were mildly elevated compared with age-matched controls. Thus, membrane stabilization was not sufficient to provide protection during prolonged disease. Consequently, we reinvestigated skeletal muscle regeneration in ADAM12 transgenic...

STUDI KOMPARATIF KONSEP KETUHANAN ISLAM DAN AGAMA ADAM PADA KOMUNITAS SAMIN

Directory of Open Access Journals (Sweden)

Mohammad Rosyid

2012-12-01

Full Text Available Abstract: One of the problems that disturb the harmony between religious communities is a lack of understanding of the majority (mainstream religion about the local religion, and vice versa. This article aims to develop such inter-religious understanding by comparing between Islam and the religion of Adam, a local religion of Samin community. The comparative study was made within the scope of the concept of God in both religions. This study found that the understanding between Islam the religion of Adam about the concept of God is essential in common. God called Allah (in Islam and Yai (in the religion of Adam are equally perceived as condescendent, an only single power, and the Almighty. Both communities also share Adam as the first man in the world. So, it is not proportional if the public ridicule Samin community with atheist stigma.Abstrak: Salah satu problem yang mengganggu keharmonisan antar komunitas beragama adalah kurangnya pemahaman pemeluk agama mayoritas (mainstream di suatu negara tentang agama lokal, dan demikian pula sebaliknya. Artikel ini bertujuan untuk membangun kesalingpahaman antar pemeluk agama itu dengan melakukan kaji banding antara agama Islam dengan agama Adam, sebuah agama lokal komunitas Samin. Kaji banding itu dilakukan dalam lingkup konsep ketuhanan dalam dua agama itu. Kajian ini menemukan bahwa pemahaman antara Islam dengan agama Adam tentang konsep Tuhan memiliki kesamaan secara esensial. Tuhan yang disebut dengan Allah (dalam Islam dan Yai (dalam agama Adam sama-sama dipersepsikan sebagai tempat berlindung, kekuatan tunggal, dan Zat Yang Maha segala-galanya. Kedua komunitas juga sama dalam memandang Adam sebagai manusia yang pertama di dunia. Dengan adanya pemahaman itu maka tidak proporsional lagi jika publik mengolok-olok komunitas Samin dengan stigma ateis.

ADAM10 missense mutations potentiate β-amyloid accumulation by impairing prodomain chaperone function.

Science.gov (United States)

Suh, Jaehong; Choi, Se Hoon; Romano, Donna M; Gannon, Moira A; Lesinski, Andrea N; Kim, Doo Yeon; Tanzi, Rudolph E

2013-10-16

The generation of Aβ, the main component of senile plaques in Alzheimer's disease (AD), is precluded by α-secretase cleavage within the Aβ domain of the amyloid precursor protein (APP). We identified two rare mutations (Q170H and R181G) in the prodomain of the metalloprotease, ADAM10, that cosegregate with late-onset AD (LOAD). Here, we addressed the pathogenicity of these mutations in transgenic mice expressing human ADAM10 in brain. In Tg2576 AD mice, both mutations attenuated α-secretase activity of ADAM10 and shifted APP processing toward β-secretase-mediated cleavage, while enhancing Aβ plaque load and reactive gliosis. We also demonstrated ADAM10 expression potentiates adult hippocampal neurogenesis, which is reduced by the LOAD mutations. Mechanistically, both LOAD mutations impaired the molecular chaperone activity of ADAM10 prodomain. Collectively, these findings suggest that diminished α-secretase activity, owing to LOAD ADAM10 prodomain mutations, leads to AD-related pathology, strongly supporting ADAM10 as a promising therapeutic target for this devastating disease. Copyright © 2013 Elsevier Inc. All rights reserved.

Adam Smith and the Invisible Hand: From Metaphor to Myth

OpenAIRE

Gavin Kennedy

2009-01-01

Adam Smith and the ‘invisible hand’ are nearly synonymous in modern economic thinking. Adam Smith is strongly associated with the invisible hand, understood as a general rule that people in realising their self-interests unintentionally benefit the public good. The attribution to Smith is challengeable. Adam Smith’s use of the metaphor was much more modest; it was re-invented in the 1930s and 1940s onwards to bolster mathematical treatments of capitalism (Samuelson, Friedman) and to sup...

Nuclear trafficking of the HIV-1 pre-integration complex depends on the ADAM10 intracellular domain

International Nuclear Information System (INIS)

Endsley, Mark A.; Somasunderam, Anoma D.; Li, Guangyu; Oezguen, Numan; Thiviyanathan, Varatharasa; Murray, James L.; Rubin, Donald H.; Hodge, Thomas W.

2014-01-01

Previously, we showed that ADAM10 is necessary for HIV-1 replication in primary human macrophages and immortalized cell lines. Silencing ADAM10 expression interrupted the HIV-1 life cycle prior to nuclear translocation of viral cDNA. Furthermore, our data indicated that HIV-1 replication depends on the expression of ADAM15 and γ-secretase, which proteolytically processes ADAM10. Silencing ADAM15 or γ-secretase expression inhibits HIV-1 replication between reverse transcription and nuclear entry. Here, we show that ADAM10 expression also supports replication in CD4 + T lymphocytes. The intracellular domain (ICD) of ADAM10 associates with the HIV-1 pre-integration complex (PIC) in the cytoplasm and immunoprecipitates and co-localizes with HIV-1 integrase, a key component of PIC. Taken together, our data support a model whereby ADAM15/γ-secretase processing of ADAM10 releases the ICD, which then incorporates into HIV-1 PIC to facilitate nuclear trafficking. Thus, these studies suggest ADAM10 as a novel therapeutic target for inhibiting HIV-1 prior to nuclear entry. - Highlights: • Nuclear trafficking of the HIV-1 pre-integration complex depends on ADAM10. • ADAM10 associates with HIV-1 integrase in the pre-integration complex. • HIV-1 replication depends on the expression of ADAM15 and γ-secretase. • Silencing ADAM15 or γ-secretase expression inhibits nuclear import of viral cDNA. • ADAM10 is important for HIV-1 replication in human macrophages and CD4 + T lymphocytes

Nuclear trafficking of the HIV-1 pre-integration complex depends on the ADAM10 intracellular domain

Energy Technology Data Exchange (ETDEWEB)

Endsley, Mark A., E-mail: maendsle@utmb.edu [Department Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 (United States); Somasunderam, Anoma D., E-mail: asomasun@utmb.edu [Department Internal Medicine, Division of Infectious Diseases, University of Texas Medical Branch, 301 University Blvd, Galveston, TX 77555 (United States); Li, Guangyu, E-mail: LIG001@mail.etsu.edu [Department of Internal Medicine, Quillen College of Medicine, East Tennessee State University, Johnson City, TN 37614 (United States); Oezguen, Numan, E-mail: numan.oezguen@bcm.edu [Department of Pathology and Immunology, Microbiome Center, Texas Children' s Hospital, Houston, TX 77030 (United States); Thiviyanathan, Varatharasa, E-mail: Varatharasa.Thiviyanathan@uth.tmc.edu [Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030 (United States); Murray, James L., E-mail: jmurray100@yahoo.com [GeneTAG Technology, Inc., 3155 Northwoods Place, Norcross, GA 30071 (United States); Rubin, Donald H., E-mail: don.h.rubin@vanderbilt.edu [Research Medicine, VA Tennessee Valley Healthcare System, 1310 24th Ave. South, Nashville, TN 37212 (United States); Departments of Medicine, Pathology, Microbiology and Immunology, Vanderbilt University School of Medicine, 1161 21st Ave South, Nashville, TN 37232 (United States); Hodge, Thomas W., E-mail: twhodge3@gmail.com [Pre-clinical and Antiviral Research, Tamir Biotechnology, Inc., 12625 High Bluff Dr., Suite 113, San Diego, CA 92130 (United States); and others

2014-04-15

Previously, we showed that ADAM10 is necessary for HIV-1 replication in primary human macrophages and immortalized cell lines. Silencing ADAM10 expression interrupted the HIV-1 life cycle prior to nuclear translocation of viral cDNA. Furthermore, our data indicated that HIV-1 replication depends on the expression of ADAM15 and γ-secretase, which proteolytically processes ADAM10. Silencing ADAM15 or γ-secretase expression inhibits HIV-1 replication between reverse transcription and nuclear entry. Here, we show that ADAM10 expression also supports replication in CD4{sup +} T lymphocytes. The intracellular domain (ICD) of ADAM10 associates with the HIV-1 pre-integration complex (PIC) in the cytoplasm and immunoprecipitates and co-localizes with HIV-1 integrase, a key component of PIC. Taken together, our data support a model whereby ADAM15/γ-secretase processing of ADAM10 releases the ICD, which then incorporates into HIV-1 PIC to facilitate nuclear trafficking. Thus, these studies suggest ADAM10 as a novel therapeutic target for inhibiting HIV-1 prior to nuclear entry. - Highlights: • Nuclear trafficking of the HIV-1 pre-integration complex depends on ADAM10. • ADAM10 associates with HIV-1 integrase in the pre-integration complex. • HIV-1 replication depends on the expression of ADAM15 and γ-secretase. • Silencing ADAM15 or γ-secretase expression inhibits nuclear import of viral cDNA. • ADAM10 is important for HIV-1 replication in human macrophages and CD4{sup +} T lymphocytes.

Erbb2 up-regulation of ADAM12 expression accelerates skin cancer progression.

Science.gov (United States)

Rao, Velidi H; Vogel, Kristen; Yanagida, Jodi K; Marwaha, Nitin; Kandel, Amrit; Trempus, Carol; Repertinger, Susan K; Hansen, Laura A

2015-10-01

Solar ultraviolet (UV) radiation can cause severe damage to the skin and is the primary cause of most skin cancer. UV radiation causes DNA damage leading to mutations and also activates the Erbb2/HER2 receptor through indirect mechanisms involving reactive oxygen species. We hypothesized that Erbb2 activation accelerates the malignant progression of UV-induced skin cancer. Following the induction of benign squamous papillomas by UV exposure of v-ras(Ha) transgenic Tg.AC mice, mice were treated topically with the Erbb2 inhibitor AG825 and tumor progression monitored. AG825 treatment reduced tumor volume, increased tumor regression, and delayed the development of malignant squamous cell carcinoma (SCC). Progression to malignancy was associated with increased Erbb2 and ADAM12 (A Disintegin And Metalloproteinase 12) transcripts and protein, while inhibition of Erbb2 blocked the increase in ADAM12 message upon malignant progression. Similarly, human SCC and SCC cell lines had increased ADAM12 protein and transcripts when compared to normal controls. To determine whether Erbb2 up-regulation of ADAM12 contributed to malignant progression of skin cancer, Erbb2 expression was modulated in cultured SCC cells using forced over-expression or siRNA targeting, demonstrating up-regulation of ADAM12 by Erbb2. Furthermore, ADAM12 transfection or siRNA targeting revealed that ADAM12 increased both the migration and invasion of cutaneous SCC cells. Collectively, these results suggest Erbb2 up-regulation of ADAM12 as a novel mechanism contributing to the malignant progression of UV-induced skin cancer. Inhibition of Erbb2/HER2 reduced tumor burden, increased tumor regression, and delayed the progression of benign skin tumors to malignant SCC in UV-exposed mice. Inhibition of Erbb2 suppressed the increase in metalloproteinase ADAM12 expression in skin tumors, which in turn increased migration and tumor cell invasiveness. © 2014 Wiley Periodicals, Inc.

Cell-surface metalloprotease ADAM12 is internalized by a clathrin- and Grb2-dependent mechanism

DEFF Research Database (Denmark)

Hansen, Dorte Stautz; Leyme, Anthony; Grandal, Michael Vibo

2012-01-01

ADAM12 (A Disintegrin And Metalloprotease 12), a member of the ADAMs family of transmembrane proteins, is involved in ectodomain shedding, cell-adhesion and signaling, with important implications in cancer. Therefore, mechanisms that regulate the levels and activity of ADAM12 at the cell-surface ......ADAM12 (A Disintegrin And Metalloprotease 12), a member of the ADAMs family of transmembrane proteins, is involved in ectodomain shedding, cell-adhesion and signaling, with important implications in cancer. Therefore, mechanisms that regulate the levels and activity of ADAM12 at the cell...

Bordism, stable homotopy and adams spectral sequences

CERN Document Server

Kochman, Stanley O

1996-01-01

This book is a compilation of lecture notes that were prepared for the graduate course "Adams Spectral Sequences and Stable Homotopy Theory" given at The Fields Institute during the fall of 1995. The aim of this volume is to prepare students with a knowledge of elementary algebraic topology to study recent developments in stable homotopy theory, such as the nilpotence and periodicity theorems. Suitable as a text for an intermediate course in algebraic topology, this book provides a direct exposition of the basic concepts of bordism, characteristic classes, Adams spectral sequences, Brown-Peter

The ADaptation and Anticipation Model (ADAM) of sensorimotor synchronization

Science.gov (United States)

van der Steen, M. C. (Marieke); Keller, Peter E.

2013-01-01

A constantly changing environment requires precise yet flexible timing of movements. Sensorimotor synchronization (SMS)—the temporal coordination of an action with events in a predictable external rhythm—is a fundamental human skill that contributes to optimal sensory-motor control in daily life. A large body of research related to SMS has focused on adaptive error correction mechanisms that support the synchronization of periodic movements (e.g., finger taps) with events in regular pacing sequences. The results of recent studies additionally highlight the importance of anticipatory mechanisms that support temporal prediction in the context of SMS with sequences that contain tempo changes. To investigate the role of adaptation and anticipatory mechanisms in SMS we introduce ADAM: an ADaptation and Anticipation Model. ADAM combines reactive error correction processes (adaptation) with predictive temporal extrapolation processes (anticipation) inspired by the computational neuroscience concept of internal models. The combination of simulations and experimental manipulations based on ADAM creates a novel and promising approach for exploring adaptation and anticipation in SMS. The current paper describes the conceptual basis and architecture of ADAM. PMID:23772211

Economic impacts of geothermal development in Skamania County, Washington

International Nuclear Information System (INIS)

Lesser, J.A.

1992-07-01

This report estimates the local economic impacts that could be anticipated from the development of a 100 megawatt (MW) geothermal power plant in eastern Skamania County, Washington, near Mt. Adams, as shown in Figure 1. The study was commissioned by the Bonneville Power Administration to quantify such impacts as part of regional confirmation work recommended by the Northwest Power Planning Council. Skamania County was chosen due to both identified geothermal resources and developer interest. The analysis will focus on two phases: a plant construction phase, including well field development, generating plant construction, and transmission line construction; and an operations phase. Economic impacts will occur to the extent that construction and operations affect the local economy. These impacts will depend on the existing structure of the Skamania County economy and estimates of revenues that may accrue to the county as a result of plant construction, operation, and maintenance. Specific impacts may include additional direct employment at the plant, secondary impacts from wage payments being used to purchase locally produced goods and services, and impacts due to expenditures of royalty and tax payments received by the county. The basis for the analysis of economic impacts in this study is the US Forest Service IMPLAN input-output modeling system

Adams Predictor-Corrector Systems for Solving Fuzzy Differential Equations

Directory of Open Access Journals (Sweden)

Dequan Shang

2013-01-01

Full Text Available A predictor-corrector algorithm and an improved predictor-corrector (IPC algorithm based on Adams method are proposed to solve first-order differential equations with fuzzy initial condition. These algorithms are generated by updating the Adams predictor-corrector method and their convergence is also analyzed. Finally, the proposed methods are illustrated by solving an example.

ADAM10 mediates trastuzumab resistance and is correlated with survival in HER2 positive breast cancer

Science.gov (United States)

Feldinger, Katharina; Generali, Daniele; Kramer-Marek, Gabriela; Gijsen, Merel; Ng, Tzi Bun; Wong, Jack Ho; Strina, Carla; Cappelletti, Mariarosa; Andreis, Daniele; Li, Ji-Liang; Bridges, Esther; Turley, Helen; Leek, Russell; Roxanis, Ioannis; Capala, Jacek; Murphy, Gillian; Harris, Adrian L.; Kong, Anthony

2014-01-01

Trastuzumab prolongs survival in HER2 positive breast cancer patients. However, resistance remains a challenge. We have previously shown that ADAM17 plays a key role in maintaining HER2 phosphorylation during trastuzumab treatment. Beside ADAM17, ADAM10 is the other well characterized ADAM protease responsible for HER ligand shedding. Therefore, we studied the role of ADAM10 in relation to trastuzumab treatment and resistance in HER2 positive breast cancer. ADAM10 expression was assessed in HER2 positive breast cancer cell lines and xenograft mice treated with trastuzumab. Trastuzumab treatment increased ADAM10 levels in HER2 positive breast cancer cells (p≤0.001 in BT474; p≤0.01 in SKBR3) and in vivo (p≤0.0001) compared to control, correlating with a decrease in PKB phosphorylation. ADAM10 inhibition or knockdown enhanced trastuzumab response in naïve and trastuzumab resistant breast cancer cells. Trastuzumab monotherapy upregulated ADAM10 (p≤0.05); and higher pre-treatment ADAM10 levels correlated with decreased clinical response (p≤0.05) at day 21 in HER2 positive breast cancer patients undergoing a trastuzumab treatment window study. Higher ADAM10 levels correlated with poorer relapse-free survival (p≤0.01) in a cohort of HER2 positive breast cancer patients. Our studies implicate a role of ADAM10 in acquired resistance to trastuzumab and establish ADAM10 as a therapeutic target and a potential biomarker for HER2 positive breast cancer patients. PMID:24952873

Structural Basis for Regulated Proteolysis by the α-Secretase ADAM10.

Science.gov (United States)

Seegar, Tom C M; Killingsworth, Lauren B; Saha, Nayanendu; Meyer, Peter A; Patra, Dhabaleswar; Zimmerman, Brandon; Janes, Peter W; Rubinstein, Eric; Nikolov, Dimitar B; Skiniotis, Georgios; Kruse, Andrew C; Blacklow, Stephen C

2017-12-14

Cleavage of membrane-anchored proteins by ADAM (a disintegrin and metalloproteinase) endopeptidases plays a key role in a wide variety of biological signal transduction and protein turnover processes. Among ADAM family members, ADAM10 stands out as particularly important because it is both responsible for regulated proteolysis of Notch receptors and catalyzes the non-amyloidogenic α-secretase cleavage of the Alzheimer's precursor protein (APP). We present here the X-ray crystal structure of the ADAM10 ectodomain, which, together with biochemical and cellular studies, reveals how access to the enzyme active site is regulated. The enzyme adopts an unanticipated architecture in which the C-terminal cysteine-rich domain partially occludes the enzyme active site, preventing unfettered substrate access. Binding of a modulatory antibody to the cysteine-rich domain liberates the catalytic domain from autoinhibition, enhancing enzymatic activity toward a peptide substrate. Together, these studies reveal a mechanism for regulation of ADAM activity and offer a roadmap for its modulation. Copyright © 2017 Elsevier Inc. All rights reserved.

Research on Goods and the Ship Interaction Based on ADAMS

Directory of Open Access Journals (Sweden)

Song Fangzhen

2017-01-01

Full Text Available The equivalent method of the relative movement goods on board is discussed in details. This method is to establish dynamic model based on moving trajectory of gravity-center for goods and to take rigid body geometric model with the trajectory as constraints in ADAMS. The difference of simulation methods for the different goods in carrier rolling is compared. The interact of relative moving objects with bulk carrier is discussed by using the ADAMS model. It is verified that the ballast water can maintain the ship’s stability by means of the ADAMS model.

Synthesis and immunostimulating properties of novel adamant-1-yl tripeptides.

Science.gov (United States)

Ribić, Rosana; Habjanec, Lidija; Vranešić, Branka; Frkanec, Ruža; Tomić, Srđanka

2012-04-01

The aim of this work was to prepare L- and D-(adamant-1-yl)-Gly-L-Ala-D-isoGln peptides in order to study their adjuvant (immunostimulating) activities. Adjuvant activity of adamant-1-yl tripeptides was tested in the mouse model using ovalbumin as an antigen and in comparison to the peptidoglycan monomer (PGM; β-D-GlcNAc-(1→4)-D-MurNAc-L-Ala-D-isoGln-mesoDAP(εNH(2) )-D-Ala-D-Ala) and structurally related adamant-2-yl tripeptides. Copyright © 2012 Verlag Helvetica Chimica Acta AG, Zürich.

Thioredoxin-1 Negatively Modulates ADAM17 Activity Through Direct Binding and Indirect Reductive Activity.

Science.gov (United States)

Granato, Daniela C; E Costa, Rute A P; Kawahara, Rebeca; Yokoo, Sami; Aragão, Annelize Z; Domingues, Romênia R; Pauletti, Bianca A; Honorato, Rodrigo V; Fattori, Juliana; Figueira, Ana Carolina M; Oliveira, Paulo S L; Consonni, Silvio R; Fernandes, Denise; Laurindo, Francisco; Hansen, Hinrich P; Paes Leme, Adriana F

2018-02-27

A disintegrin and metalloprotease 17 (ADAM17) modulates signaling events by releasing surface protein ectodomains such as TNFa and the EGFR-ligands. We have previously characterized cytoplasmic thioredoxin-1 (Trx-1) as a partner of ADAM17 cytoplasmic domain. Still, the mechanism of ADAM17 regulation by Trx-1 is unknown, and it has become of paramount importance to assess the degree of influence that Trx-1 has on metalloproteinase ADAM17. Combining discovery and targeted proteomic approaches, we uncovered that Trx-1 negatively regulates ADAM17 by direct and indirect effect. We performed cell-based assays with synthetic peptides and site-directed mutagenesis, and we demonstrated that the interaction interface of Trx-1 and ADAM17 is important for the negative regulation of ADAM17 activity. However, both Trx-1 K72A and catalytic site mutant Trx-1 C32/35S rescued ADAM17 activity, although the interaction with Trx-1 C32/35S was unaffected, suggesting an indirect effect of Trx-1. We confirmed that the Trx-1 C32/35S mutant showed diminished reductive capacity, explaining this indirect effect on increasing ADAM17 activity through oxidant levels. Interestingly, Trx-1 K72A mutant showed similar oxidant levels to Trx-1 C32/35S , even though its catalytic site was preserved. We further demonstrated that the general reactive oxygen species inhibitor, Nacetylcysteine (NAC), maintained the regulation of ADAM17 dependent of Trx-1 reductase activity levels; whereas the electron transport chain modulator, rotenone, abolished Trx-1 effect on ADAM17 activity. We show for the first time that the mechanism of ADAM17 regulation, Trx-1 dependent, can be by direct interaction and indirect effect, bringing new insights into the cross-talk between isomerases and mammalian metalloproteinases. This unexpected Trx-1 K72A behavior was due to more dimer formation and, consequently, the reduction of its Trx-1 reductase activity, evaluated through dimer verification, by gel filtration and mass

ADAM12: a novel first-trimester maternal serum marker for Down syndrome

DEFF Research Database (Denmark)

Laigaard, Jennie; Sørensen, Tina; Fröhlich, Camilla

2003-01-01

levels decrease markedly during pregnancy. ADAM12 (A disintegrin and metalloprotease) is an IGFBP-3 and IGFBP-5 protease and is present in human pregnancy serum. The goal of this study was to determine whether ADAM12 concentration in maternal serum is a useful indicator of foetal health. METHODS: We......OBJECTIVES: The concentration of bioavailable insulin-like growth factor (IGF) I and II is important to foetal growth. It is regulated by insulin-like growth factor binding proteins (IGFBP) 1 through 6. Proteolytic cleavage of IGFBP-3 takes place in human pregnancy serum; accordingly, IGFBP-3 serum...... developed an enzyme-linked immunosorbent assay (ELISA) for the quantification of ADAM12 in serum. The assay range was 42 to 667 micro g/L. Recombinant ADAM12 was used as the standard for calibration. RESULTS: We found that ADAM12 was highly stable in serum. Serum concentration increased from 180 micro g...

Expression, purification and insights into structure and folding of the ADAM22 pro domain

DEFF Research Database (Denmark)

Sørensen, Hans Peter; Jacobsen, Jonas; Nielbo, Steen

2008-01-01

. To understand the functions of human ADAM pro domains and to determine three-dimensional structures, we have screened promising targets for expression and purification properties when using Escherichia coli as the host. The pro domain of ADAM22 (ADAM22-P) expressed in E. coli was folded, as determined by CD...... and NMR spectroscopy. An ADAM22-P fragment encoding residues 26-199 could be expressed in high amounts, remained soluble above 1 mM, and was suitable for structural studies by NMR spectroscopy. CD spectroscopy and predictions suggest that the secondary structure in ADAM22-P consists of beta...

The Failed Educations of John Stuart Mill and Henry Adams.

Science.gov (United States)

Crossley, Robert

1979-01-01

Analyzes and contrasts Mill's "Autobiography" and Adams'"The Education of Henry Adams" in order to present two approaches to the nature of education and of failure. Maintains that their perspectives may serve as catalysts and cautions for contemporary theories of education and its utility and relevance. (CAM)

Adam Michnik: kriisis Euroopat ohustab rahvuslik egoism / Adam Michnik ; interv. Külli-Riin Tigasson

Index Scriptorium Estoniae

Michnik, Adam, 1946-

2009-01-01

Poola suurima kvaliteetlehe Gazeta Wyborczka petoimetaja Adam Michnik vastab küsimustele, mis puudutavad 2008. aastal alanud majanduskriisi, protektsionismi ja egoismi levikut, Ida-Euroopas levinud poliitilise ja majandusliku mudeli ümber hindamist, ladinaameerikalikku putinismi ja antikommunistlikku autoritaarsust ning trükiajakirjanduse tulevikku internetiajastul. Vt. samas: Elulugu

EMMPRIN and ADAM12 in prostate cancer: preliminary results of a prospective study.

Science.gov (United States)

Bilgin Doğru, Elif; Dizdar, Yavuz; Akşit, Ece; Ural, Feyyaz; Şanlı, Öner; Yasasever, Vildan

2014-11-01

Extracellular metalloproteinase inducer (EMMPRIN) and a disintegrin and metalloproteinase (ADAM12) play a major role in cancer invasion and metastasis owing to the fact that they are directly related to the cell microenvironment and extracellular matrix (ECM) degradation. The aim of this study was to search for an answer to the question "whether the determination of EMMPRIN and ADAM12 values especially in urine may be helpful for the early diagnosis of prostate cancer without employing invasive methods" and also to check whether they may be useful for the determination of the patients with high metastasis risk. Peripheral blood and urine from 66 prostate cancer patients (40 local, 20 locally advanced, 6 metastatic) and 14 healthy controls were evaluated by enzyme-linked immunosorbent assay (ELISA) method. Serum EMMPRIN and ADAM12 values of the patients were seen to be statistically higher than the serum EMMPRIN and ADAM12 values of the healthy controls (p=0.01 and p=0.001, respectively). The urine ADAM12 levels were significantly higher in patients (p=0.013). No significant relationships were found between urine EMMPRIN values of the patients and the healthy controls (p>0.05). Positive correlation between urine EMMPRIN-urine ADAM12 tests was found in total patients group (r=0.683, p=0.001). Our preliminary results revealed that serum EMMPRIN and ADAM12 values and urine ADAM12 values may be useful markers in prostate cancer therapy. Due to the high correlation between these two tests, we are of the opinion that the use of urine ADAM12 in clinic may be sufficient and favorable together with prostate-specific antigen (PSA) for treatment.

ADAM 12-S cleaves IGFBP-3 and IGFBP-5 and is inhibited by TIMP-3

DEFF Research Database (Denmark)

Loechel, F; Fox, J W; Murphy, G

2000-01-01

that it cleaves insulin-like growth factor binding protein-3 (IGFBP-3). This result supports a role for ADAM 12-S in the degradation of IGFBP-3 in the blood of pregnant women. Furthermore, we tested for proteolysis of other members of the IGF binding protein family and found that ADAM 12-S cleaves IGFBP-5......ADAMs are a family of multidomain proteins having proteolytic and cell adhesion activities. We have previously shown that ADAM 12-S, the secreted soluble form of human ADAM 12, is a catalytically active protease. We now describe the purification of full-length recombinant ADAM 12-S and demonstrate...

Hierarchy of ADAM12 binding to integrins in tumor cells

DEFF Research Database (Denmark)

Thodeti, Charles Kumar; Fröhlich, Camilla; Nielsen, Christian Kamp

2005-01-01

ADAMs (a disintegrin and metalloprotease) comprise a family of cell surface proteins with protease and cell-binding activities. Using different forms and fragments of ADAM12 as substrates in cell adhesion and spreading assays, we demonstrated that alpha9beta1 integrin is the main receptor for ADA...

ADAM12 and alpha9beta1 integrin are instrumental in human myogenic cell differentiation

DEFF Research Database (Denmark)

Lafuste, Peggy; Sonnet, Corinne; Chazaud, Bénédicte

2005-01-01

of alpha9 parallels that of ADAM12 and culminates at time of fusion. alpha9 and ADAM12 coimmunoprecipitate and participate to mpc adhesion. Inhibition of ADAM12/alpha9beta1 integrin interplay, by either ADAM12 antisense oligonucleotides or blocking antibody to alpha9beta1, inhibited overall mpc fusion...

Another Distortion of Adam Smith: The Case of the "Invisible Hand"

OpenAIRE

Michael Meeropol

2004-01-01

This paper addresses a major omission in the way textbook writers and journalists utilize Adam Smith’s concept of the “invisible hand” to make Adam Smith an intellectual precursor of modern neo-liberal economic policy. Specifically, the paper addresses the use of the concept of the “invisible hand” by Adam Smith to address two major issues in the debate over neo-liberal policy: the international flow of capital and its role in the location of investment projects and the inequality in the dist...

ADAM disintegrin-like domain recognition by the lymphocyte integrins α4β1 and α4β7

Science.gov (United States)

Bridges, Lance C.; Sheppard, Dean; Bowditch, Ron D.

2004-01-01

The ADAM (a disintegrin and metalloprotease) family of proteins possess both proteolytic and adhesive domains. We have established previously that the disintegrin domain of ADAM28, an ADAM expressed by human lymphocytes, is recognized by the integrin α4β1. The present study characterizes the integrin binding properties of the disintegrin-like domains of human ADAM7, ADAM28 and ADAM33 with the integrins α4β1, α4β7 and α9β1. Cell-adhesion assays demonstrated that, similar to ADAM28, the ADAM7 disintegrin domain supported α4β1-dependent Jurkat cell adhesion, whereas the ADAM33 disintegrin domain did not. The lymphocyte integrin α4β7 was also found to recognize both disintegrin domains of ADAM7 and ADAM28, but not of ADAM33. This is the first demonstration that mammalian disintegrins are capable of interacting with α4β7. All three disintegrin domains supported α9β1-dependent cell adhesion. Recognition by both α4β1 and α4β7 of ADAM7 and ADAM28 was activation-dependent, requiring either the presence of Mn2+ or an activating monoclonal antibody for cell attachment. Charge-to-alanine mutagenesis experiments revealed that the same residues within an individual ADAM disintegrin domain function in recognizing multiple integrins. However, the residues within a specific region of each ADAM disintegrin-like domain required for integrin binding were distinct. These results establish that ADAM7 and ADAM28 are recognized by the leucocyte integrins α4β1, α4β7 and α9β1. ADAM33 exclusively supported only α9β1-dependent adhesion. PMID:15504110

The Mississippi CCS Project

Energy Technology Data Exchange (ETDEWEB)

Doug Cathro

2010-09-30

The Mississippi CCS Project is a proposed large-scale industrial carbon capture and sequestration (CCS) project which would have demonstrated advanced technologies to capture and sequester carbon dioxide (CO{sub 2}) emissions from industrial sources into underground formations. Specifically, the Mississippi CCS Project was to accelerate commercialization of large-scale CO{sub 2} storage from industrial sources by leveraging synergy between a proposed petcoke to Substitute Natural Gas (SNG) plant that is selected for a Federal Loan Guarantee and would be the largest integrated anthropogenic CO{sub 2} capture, transport, and monitored sequestration program in the U.S. Gulf Coast Region. The Mississippi CCS Project was to promote the expansion of enhanced oil recovery (EOR) in the Mississippi, Alabama and Louisiana region which would supply greater energy security through increased domestic energy production. The capture, compression, pipeline, injection, and monitoring infrastructure would have continued to sequester CO{sub 2} for many years after the completion of the term of the DOE agreement. The objectives of this project were expected to be fulfilled through two distinct phases. The overall objective of Phase 1 was to develop a fully definitive project basis for a competitive Renewal Application process to proceed into Phase 2 - Design, Construction and Operations. Phase 1 included the studies that establish the engineering design basis for the capture, compression and transportation of CO{sub 2} from the MG SNG Project, and the criteria and specifications for a monitoring, verification and accounting (MVA) plan at the Soso oil field in Mississippi. The overall objective of Phase 2, was to execute design, construction and operations of three capital projects: the CO{sub 2} capture and compression equipment, the Mississippi CO{sub 2} Pipeline to Denbury's Free State Pipeline, and an MVA system at the Soso oil field.

ADAM disintegrin-like domain recognition by the lymphocyte integrins α4β1 and α4β7

OpenAIRE

Bridges, Lance C.; Sheppard, Dean; Bowditch, Ron D.

2005-01-01

The ADAM (a disintegrin and metalloprotease) family of proteins possess both proteolytic and adhesive domains. We have established previously that the disintegrin domain of ADAM28, an ADAM expressed by human lymphocytes, is recognized by the integrin α4β1. The present study characterizes the integrin binding properties of the disintegrin-like domains of human ADAM7, ADAM28 and ADAM33 with the integrins α4β1, α4β7 and α9β1. Cell-adhesion assays demonstrated that, similar to ADAM28, the ADAM7 d...

TGFβ induces proHB-EGF shedding and EGFR transactivation through ADAM activation in gastric cancer cells

International Nuclear Information System (INIS)

Ebi, Masahide; Kataoka, Hiromi; Shimura, Takaya; Kubota, Eiji; Hirata, Yoshikazu; Mizushima, Takashi; Mizoshita, Tsutomu; Tanaka, Mamoru; Mabuchi, Motoshi; Tsukamoto, Hironobu; Tanida, Satoshi; Kamiya, Takeshi; Higashiyama, Shigeki; Joh, Takashi

2010-01-01

Research highlights: → TGFβ induces EGFR transactivation through proHB-EGF shedding by activated ADAM members in gastric cancer cells. → TGFβ induces nuclear translocation of HB-EGF-CTF cleaved by ADAM members. → TGFβ enhances cell growth by EGFR transactivation and HB-EGF-CTF nuclear translocation and ADAM inhibitors block these effects. → Silencing of ADAM17 also blocks EGFR transactivation, HB-EGF-CTF nuclear translocation and cancer cell growth by TGFβ. → ADAM17 may play a crucial role in this TGFβ-HB-EGF signal transduction. -- Abstract: Background and aims: Transforming growth factor-beta (TGFβ) is known to potently inhibit cell growth. Loss of responsiveness to TGFβ inhibition on cell growth is a hallmark of many types of cancer, yet its mechanism is not fully understood. Membrane-anchored heparin-binding EGF-like growth factor (proHB-EGF) ectodomain is cleaved by a disintegrin and metalloproteinase (ADAM) members and is implicated in epidermal growth factor receptor (EGFR) transactivation. Recently, nuclear translocation of the C-terminal fragment (CTF) of pro-HB-EGF was found to induce cell growth. We investigated the association between TGFβ and HB-EGF signal transduction via ADAM activation. Materials and methods: The CCK-8 assay in two gastric cancer cell lines was used to determine the effect for cell growth by TGFβ. The effect of two ADAM inhibitors was also evaluated. Induction of EGFR phosphorylation by TGFβ was analyzed and the effect of the ADAM inhibitors was also examined. Nuclear translocation of HB-EGF-CTF by shedding through ADAM activated by TGFβ was also analyzed. EGFR transactivation, HB-EGF-CTF nuclear translocation, and cell growth were examined under the condition of ADAM17 knockdown. Result: TGFβ-induced EGFR phosphorylation of which ADAM inhibitors were able to inhibit. TGFβ induced shedding of proHB-EGF allowing HB-EGF-CTF to translocate to the nucleus. ADAM inhibitors blocked this nuclear translocation. TGF�

Microautoradiography of [123I]ADAM in mice treated with fluoxetine and serotonin reuptake inhibitors

International Nuclear Information System (INIS)

Ye, X.-X.; Chen, J.-C.; Liu, R.-S.; Wey, S.-P.; Lee, J.-S.; Chen, C.-C.; Fu, Y.-K.; Ting, Gann; Hwang, J.-J.

2004-01-01

A radiopharmaceutical, 123 I-labeled 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine ([ 123 I]ADAM), has been developed recently for evaluation of how serotonin transporters (SERT) function in the brain. However, the detailed biodistribution and specific binding in certain brain areas are not well investigated. In this study, both phosphor plate imaging and microautoradiography were applied to explore the binding characteristics of [ 123 I]ADAM in SERT neurons. The effect of two psychotropics and one narcotic on the binding of [ 123 I]ADAM to SERT was also studied. Fluoxetine and desipramine, both are psychotropics and specific SERT ligands and decreased the affinity of [ 123 I]ADAM, while p-chloroamphetamine (PCA), a narcotic, destroyed most of serotonergic neurons, as well as reducing the concentration of serotonin and the number of SERT in the brain as shown by the biodistribution of [ 123 I]ADAM. Significant and selective accumulation of [ 123 I]ADAM in the areas from midbrain to brain stem in normal mice with maximum target-to-background ratio was found at 90 minutes postinjection. A rapid clearance of [ 131 I]ADAM at 120 minutes postinjection was found in the CA1, CA3 and ThN brain areas. In addition, the inhibition effect on binding ability of [ 123 I]ADAM to SERT by the psychotropics and the narcotic was found to have the order of: PCA > fluoxetine > desipramine

[Effects of ADAM28 on biological functions of human dental pulp stem cells].

Science.gov (United States)

Zhao, Zheng; Liu, Hong-chen; E, Ling-ling; Wang, Yi; Wang, Dong-sheng

2010-06-01

To investigate the effects of a disintegrin and metalloproteinase 28 (ADAM28) on proliferation, differentiation and apoptosis of human dental pulp stem cells (HDPSCs) and the possible mechanism. Firstly, HDPSCs were isolated and cultured in vitro and identified. ADAM28 eukaryotic expression plasmid was constructed via gene rebuilt technique and transfected into HDPSCs. Then MTT chromatometry, enzyme dynamics and flow cytometry (FCM) techniques were performed to detect the effects of ADAM28 on biological characteristics of HDPSCs. Immunocytochemical and image analysis techniques were used to determine the influence of ADAM28 on HDPSCs expressing dentin sialophosphoprotein (DSPP), bone sialoprotein (BSP) and osteopontin (OPN). Statistical significance was assessed by the Student-Newman-Keuls (SNK) test with SPSS 13.0 software package. ADAM28 eukaryotic plasmid was constructed and transfected into HDPSCs for 48 hours successfully. In ADAM28 eukaryotic plasmid group, proliferation activity and index of HDPSCs were lower than those of pcDNA3.1(+) group and untransfected group significantly.Alkaline phosphatase (ALP) secretion level and percentage of apoptotic cells went up remarkly. Significant difference was detected between eukaryotic plasmid group and other groups (P<0.05). The expression level of DSPP in HDPSCs elevated significantly (P<0.05). ADAM28 could inhibit HDPSCs proliferation, promote ALP secretion activity and DSPP expression in HDPSCs and induce HDPSCs apoptosis significantly.

ADAM33 gene silencing by promoter hypermethylation as a molecular marker in breast invasive lobular carcinoma

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de Souza Emanuel M

2009-03-01

Full Text Available Abstract Background ADAM33 protein is a member of the family of transmembrane glycoproteins composed of multidomains. ADAM family members have different activities, such as proteolysis and adhesion, making them good candidates to mediate the extracellular matrix remodelling and changes in cellular adhesion that characterise certain pathologies and cancer development. It was reported that one family member, ADAM23, is down-regulated by promoter hypermethylation. This seems to correlate with tumour progression and metastasis in breast cancer. In this study, we explored the involvement of ADAM33, another ADAM family member, in breast cancer. Methods First, we analysed ADAM33 expression in breast tumour cell lines by RT-PCR and western blotting. We also used 5-aza-2'-deoxycytidine (5azadCR treatment and DNA bisulphite sequencing to study the promoter methylation of ADAM33 in breast tumour cell lines. We evaluated ADAM33 methylation in primary tumour samples by methylation specific PCR (MSP. Finally, ADAM33 promoter hypermethylation was correlated with clinicopathological data using the chi-square test and Fisher's exact test. Results The expression analysis of ADAM33 in breast tumour cell lines by RT-PCR revealed gene silencing in 65% of tumour cell lines. The corresponding lack of ADAM33 protein was confirmed by western blotting. We also used 5-aza-2'-deoxycytidine (5-aza-dCR demethylation and bisulphite sequencing methodologies to confirm that gene silencing is due to ADAM33 promoter hypermethylation. Using MSP, we detected ADAM33 promoter hypermethylation in 40% of primary breast tumour samples. The correlation between methylation pattern and patient's clinicopathological data was not significantly associated with histological grade; tumour stage (TNM; tumour size; ER, PR or ERBB2 status; lymph node status; metastasis or recurrence. Methylation frequency in invasive lobular carcinoma (ILC was 76.2% compared with 25.5% in invasive ductal carcinoma

ADAM33 gene silencing by promoter hypermethylation as a molecular marker in breast invasive lobular carcinoma

International Nuclear Information System (INIS)

Seniski, Gerusa G; Zanata, Silvio M; Costa, Fabrício F; Klassen, Giseli; Camargo, Anamaria A; Ierardi, Daniela F; Ramos, Edneia AS; Grochoski, Mariana; Ribeiro, Enilze SF; Cavalli, Iglenir J; Pedrosa, Fabio O; Souza, Emanuel M de

2009-01-01

ADAM33 protein is a member of the family of transmembrane glycoproteins composed of multidomains. ADAM family members have different activities, such as proteolysis and adhesion, making them good candidates to mediate the extracellular matrix remodelling and changes in cellular adhesion that characterise certain pathologies and cancer development. It was reported that one family member, ADAM23, is down-regulated by promoter hypermethylation. This seems to correlate with tumour progression and metastasis in breast cancer. In this study, we explored the involvement of ADAM33, another ADAM family member, in breast cancer. First, we analysed ADAM33 expression in breast tumour cell lines by RT-PCR and western blotting. We also used 5-aza-2'-deoxycytidine (5azadCR) treatment and DNA bisulphite sequencing to study the promoter methylation of ADAM33 in breast tumour cell lines. We evaluated ADAM33 methylation in primary tumour samples by methylation specific PCR (MSP). Finally, ADAM33 promoter hypermethylation was correlated with clinicopathological data using the chi-square test and Fisher's exact test. The expression analysis of ADAM33 in breast tumour cell lines by RT-PCR revealed gene silencing in 65% of tumour cell lines. The corresponding lack of ADAM33 protein was confirmed by western blotting. We also used 5-aza-2'-deoxycytidine (5-aza-dCR) demethylation and bisulphite sequencing methodologies to confirm that gene silencing is due to ADAM33 promoter hypermethylation. Using MSP, we detected ADAM33 promoter hypermethylation in 40% of primary breast tumour samples. The correlation between methylation pattern and patient's clinicopathological data was not significantly associated with histological grade; tumour stage (TNM); tumour size; ER, PR or ERBB2 status; lymph node status; metastasis or recurrence. Methylation frequency in invasive lobular carcinoma (ILC) was 76.2% compared with 25.5% in invasive ductal carcinoma (IDC), and this difference was

Dissecting the role of ADAM10 as a mediator of Staphylococcus aureus α-toxin action.

Science.gov (United States)

von Hoven, Gisela; Rivas, Amable J; Neukirch, Claudia; Klein, Stefan; Hamm, Christian; Qin, Qianqian; Meyenburg, Martina; Füser, Sabine; Saftig, Paul; Hellmann, Nadja; Postina, Rolf; Husmann, Matthias

2016-07-01

Staphylococcus aureus is a leading cause of bacterial infections in humans, including life-threatening diseases such as pneumonia and sepsis. Its small membrane-pore-forming α-toxin is considered an important virulence factor. By destroying cell-cell contacts through cleavage of cadherins, the metalloproteinase ADAM10 (a disintegrin and metalloproteinase 10) critically contributes to α-toxin-dependent pathology of experimental S. aureus infections in mice. Moreover, ADAM10 was proposed to be a receptor for α-toxin. However, it is unclear whether the catalytic activity or specific domains of ADAM10 are involved in mediating binding and/or subsequent cytotoxicity of α-toxin. Also, it is not known how α-toxin triggers ADAM10's enzymatic activity, and whether ADAM10 is invariably required for all α-toxin action on cells. In the present study, we show that efficient cleavage of the ADAM10 substrate epithelial cadherin (E-cadherin) requires supra-cytotoxic concentrations of α-toxin, leading to significant increases in intracellular [Ca(2+)]; the fall in cellular ATP levels, typically following membrane perforation, became observable at far lower concentrations. Surprisingly, ADAM10 was dispensable for α-toxin-dependent xenophagic targeting of S. aureus, whereas a role for α-toxin attack on the plasma membrane was confirmed. The catalytic site of ADAM10, furin cleavage site, cysteine switch and intracellular domain of ADAM10 were not required for α-toxin binding and subsequent cytotoxicity. In contrast, an essential role for the disintegrin domain and the prodomain emerged. Thus, co-expression of the prodomain with prodomain-deficient ADAM10 reconstituted binding of α-toxin and susceptibility of ADAM10-deficient cells. The results of the present study may help to inform structural analyses of α-toxin-ADAM10 interactions and to design novel strategies to counteract S. aureus α-toxin action. © 2016 The Author(s). published by Portland Press Limited on behalf

ADAM12 in human liver cancers: TGF-beta-regulated expression in stellate cells is associated with matrix remodeling

DEFF Research Database (Denmark)

Le Pabic, Hélène; Bonnier, Dominique; Wewer, Ulla M

2003-01-01

"A disintegrin and metalloproteinases" (ADAMs) form a family of cell-surface glycoproteins with potential protease and cell-adhesion activities. We have investigated ADAM expression in human liver cancers and their regulation by several cytokines involved in liver injury. Using degenerative RT...... carcinomas (up to 3- and 6-fold, respectively) and liver metastases from colonic carcinomas (up to 40- and 60-fold, respectively). The up-regulation of both ADAM9 and ADAM12 was correlated with an increase in matrix metalloproteinase 2 expression and activity. In conclusion, in liver cancers ADAM9 and ADAM12......-PCR, cDNA encoding sequences for ADAM9 and ADAM12 were identified in human activated hepatic stellate cells (HSCs). Northern blot analyses showed that HSCs, but not hepatocytes, expressed transcripts for ADAM9 messenger RNA (mRNA) and both the long and short forms of ADAM12. This expression...

From Adam Swift to Adam Smith: How the "Invisible Hand" Overcomes Middle Class Hypocrisy

Science.gov (United States)

Tooley, James

2007-01-01

This paper challenges Richard Pring's suggestion that parents using private education may be undermining the desire for social justice and equality, using recent arguments of Adam Swift as a springboard. Swift's position on the banning of private schools, which uses a Rawlsian "veil of ignorance" argument, is explored, and it is suggested that, if…

ADAM 12 as a second-trimester maternal serum marker in screening for Down syndrome

DEFF Research Database (Denmark)

Christiansen, Michael; Spencer, Kevin; Laigaard, Jennie

2007-01-01

ADAM 12 is a placenta-derived glycoprotein that is involved in growth and differentiation. The maternal serum concentration of ADAM 12 is a potential first-trimester maternal serum marker of Down syndrome (DS). Here we examine the potential of ADAM 12 as a second-trimester maternal serum marker...

In silico investigation of ADAM12 effect on TGF-β receptors trafficking

Directory of Open Access Journals (Sweden)

LeMeur Nolwenn

2009-09-01

Full Text Available Abstract Background The transforming growth factor beta is known to have pleiotropic effects, including differentiation, proliferation and apoptosis. However the underlying mechanisms remain poorly understood. The regulation and effect of TGF-β signaling is complex and highly depends on specific protein context. In liver, we have recently showed that the disintegrin and metalloproteinase ADAM12 interacts with TGF-β receptors and modulates their trafficking among membranes, a crucial point in TGF-β signaling and development of fibrosis. The present study aims to better understand how ADAM12 impacts on TGF-β receptors trafficking and TGF-β signaling. Findings We extracted qualitative biological observations from experimental data and defined a family of models producing a behavior compatible with the presence of ADAM12. We computationally explored the properties of this family of models which allowed us to make novel predictions. We predict that ADAM12 increases TGF-β receptors internalization rate between the cell surface and the endosomal membrane. It also appears that ADAM12 modifies TGF-β signaling shape favoring a permanent response by removing the transient component observed under physiological conditions. Conclusion In this work, confronting differential models with qualitative biological observations, we obtained predictions giving new insights into the role of ADAM12 in TGF-β signaling and hepatic fibrosis process.

ADAM and ADAMTS Family Proteins and Snake Venom Metalloproteinases: A Structural Overview

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Soichi Takeda

2016-05-01

Full Text Available A disintegrin and metalloproteinase (ADAM family proteins constitute a major class of membrane-anchored multidomain proteinases that are responsible for the shedding of cell-surface protein ectodomains, including the latent forms of growth factors, cytokines, receptors and other molecules. Snake venom metalloproteinases (SVMPs are major components in most viper venoms. SVMPs are primarily responsible for hemorrhagic activity and may also interfere with the hemostatic system in envenomed animals. SVMPs are phylogenetically most closely related to ADAMs and, together with ADAMs and related ADAM with thrombospondin motifs (ADAMTS family proteinases, constitute adamalysins/reprolysins or the M12B clan (MEROPS database of metalloproteinases. Although the catalytic domain structure is topologically similar to that of other metalloproteinases such as matrix metalloproteinases, the M12B proteinases have a modular structure with multiple non-catalytic ancillary domains that are not found in other proteinases. Notably, crystallographic studies revealed that, in addition to the conserved metalloproteinase domain, M12B members share a hallmark cysteine-rich domain designated as the “ADAM_CR” domain. Despite their name, ADAMTSs lack disintegrin-like structures and instead comprise two ADAM_CR domains. This review highlights the current state of our knowledge on the three-dimensional structures of M12B proteinases, focusing on their unique domains that may collaboratively participate in directing these proteinases to specific substrates.

The Role of Landscape in the Distribution of Deer-Vehicle Collisions in South Mississippi

Energy Technology Data Exchange (ETDEWEB)

McKee, Jacob J [ORNL; Cochran, David [University of Southern Mississippi, The

2012-01-01

Deer-vehicle collisions (DVCs) have a negative impact on the economy, traffic safety, and the general well-being of otherwise healthy deer. To mitigate DVCs, it is imperative to gain a better understanding of factors that play a role in their spatial distribution. Much of the existing research on DVCs in the United States has been inconclusive, pointing to a variety of causal factors that seem more specific to study site and region than indicative of broad patterns. Little DVC research has been conducted in the southern United States, making the region particularly important with regard to this issue. In this study, we evaluate landscape factors that contributed to the distribution of 347 DVCs that occurred in Forrest and Lamar Counties of south Mississippi, from 2006 to 2009. Using nearest-neighbor and discriminant analysis, we demonstrate that DVCs in south Mississippi are not random spatial phenomena. We also develop a classification model that identified seven landscape metrics, explained 100% of the variance, and could distinguish DVCs from control sites with an accuracy of 81.3 percent.

The Disintegrin and Metalloprotease ADAM12 Is Associated with TGF-β-Induced Epithelial to Mesenchymal Transition.

Directory of Open Access Journals (Sweden)

Michaël Ruff

Full Text Available The increased expression of the Disintegrin and Metalloprotease ADAM12 has been associated with human cancers, however its role remain unclear. We have previously reported that ADAM12 expression is induced by the transforming growth factor, TGF-β and promotes TGF-β-dependent signaling through interaction with the type II receptor of TGF-β. Here we explore the implication of ADAM12 in TGF-β-mediated epithelial to mesenchymal transition (EMT, a key process in cancer progression. We show that ADAM12 expression is correlated with EMT markers in human breast cancer cell lines and biopsies. Using a non-malignant breast epithelial cell line (MCF10A, we demonstrate that TGF-β-induced EMT increases expression of the membrane-anchored ADAM12L long form. Importantly, ADAM12L overexpression in MCF10A is sufficient to induce loss of cell-cell contact, reorganization of actin cytoskeleton, up-regulation of EMT markers and chemoresistance. These effects are independent of the proteolytic activity but require the cytoplasmic tail and are specific of ADAM12L since overexpression of ADAM12S failed to induce similar changes. We further demonstrate that ADAM12L-dependent EMT is associated with increased phosphorylation of Smad3, Akt and ERK proteins. Conversely, inhibition of TGF-β receptors or ERK activities reverses ADAM12L-induced mesenchymal phenotype. Together our data demonstrate that ADAM12L is associated with EMT and contributes to TGF-β-dependent EMT by favoring both Smad-dependent and Smad-independent pathways.

The sorting protein PACS-2 promotes ErbB signalling by regulating recycling of the metalloproteinase ADAM17

DEFF Research Database (Denmark)

Dombernowsky, Sarah Louise; Samsøe-Petersen, Jacob; Petersen, Camilla Hansson

2015-01-01

The metalloproteinase ADAM17 activates ErbB signalling by releasing ligands from the cell surface, a key step underlying epithelial development, growth and tumour progression. However, mechanisms acutely controlling ADAM17 cell-surface availability to modulate the extent of ErbB ligand release....... PACS-2 co-localizes with ADAM17 on early endosomes and PACS-2 knockdown decreases the recycling and stability of internalized ADAM17. Hence, PACS-2 sustains ADAM17 cell-surface activity by diverting ADAM17 away from degradative pathways. Interestingly, Pacs2-deficient mice display significantly reduced...

MicroRNA-147b regulates vascular endothelial barrier function by targeting ADAM15 expression.

Directory of Open Access Journals (Sweden)

Victor Chatterjee

Full Text Available A disintegrin and metalloproteinase15 (ADAM15 has been shown to be upregulated and mediate endothelial hyperpermeability during inflammation and sepsis. This molecule contains multiple functional domains with the ability to modulate diverse cellular processes including cell adhesion, extracellular matrix degradation, and ectodomain shedding of transmembrane proteins. These characteristics make ADAM15 an attractive therapeutic target in various diseases. The lack of pharmacological inhibitors specific to ADAM15 prompted our efforts to identify biological or molecular tools to alter its expression for further studying its function and therapeutic implications. The goal of this study was to determine if ADAM15-targeting microRNAs altered ADAM15-induced endothelial barrier dysfunction during septic challenge by bacterial lipopolysaccharide (LPS. An in silico analysis followed by luciferase reporter assay in human vascular endothelial cells identified miR-147b with the ability to target the 3' UTR of ADAM15. Transfection with a miR-147b mimic led to decreased total, as well as cell surface expression of ADAM15 in endothelial cells, while miR-147b antagomir produced an opposite effect. Functionally, LPS-induced endothelial barrier dysfunction, evidenced by a reduction in transendothelial electric resistance and increase in albumin flux across endothelial monolayers, was attenuated in cells treated with miR-147b mimics. In contrast, miR-147b antagomir exerted a permeability-increasing effect in vascular endothelial cells similar to that caused by LPS. Taken together, these data suggest the potential role of miR147b in regulating endothelial barrier function by targeting ADAM15 expression.

Recombinant disintegrin domain of ADAM15 inhibits the proliferation and migration of Bel-7402 cells

International Nuclear Information System (INIS)

Hou, Y.; Chu, M.; Du, F.F.; Lei, J.Y.; Chen, Y.; Zhu, R.Y.; Gong, X.H.; Ma, X.; Jin, J.

2013-01-01

Highlights: •rhddADAM15 inhibited the proliferation and migration of Bel-7402 cells. •rhddADAM15 inhibited growth and metastasis of Bel-7402 cells in zebrafish xenograft. •rhddADAM15 induced apoptosis in Bel-7402 cells and somatic cells of zebrafish. •Cell-cycle in Bel-7402 cells showed a partial G 2 /S arrest. •Activity of caspases 8, 9 and 3 was increased in rhddADAM15-treated Bel-7402 cells. -- Abstract: ADAM15 (A Disintegrin And Metalloproteinase 15), a transmembrane protein containing seven domains, interacts with some integrins via its disintegrin domain and overexpresses in many solid tumors. In this study, the effect of the recombinant human disintegrin domain (rhddADAM15) on the proliferation and migration of Bel-7402 cells was evaluated in vitro and in vivo in zebrafish xenografts. rhddADAM15 (4 μM) severely inhibited the proliferation and migration of Bel-7402 cells, inducing a partial G 2 /S arrest and morphological nucleus changes of apoptosis. Moreover, the activity of caspases 8, 9 and 3 in Bel-7402 cells was increased. In addition, the zebrafish was used as a model for apoptosis-induction and tumor-xenograft. rhddADAM15 (1 pM) inhibited the growth and metastasis of Bel-7402 cell xenografts in zebrafish and a lower concentration (0.1 pM) induced severe apoptosis in the somatic cells of zebrafish. In conclusion, our data identified rhddADAM15 as a potent inhibitor of tumor growth and metastasis, making it a promising tool for use in anticancer treatment

Recombinant disintegrin domain of ADAM15 inhibits the proliferation and migration of Bel-7402 cells

Energy Technology Data Exchange (ETDEWEB)

Hou, Y. [Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Pharmaceutical Sciences, Jiangnan University, 1800 Lihu Rd., Wuxi, Jiangsu 214122 (China); Chu, M. [Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Medicine, Jiangnan University, 1800 Lihu Rd., Wuxi, Jiangsu 214122 (China); Du, F.F.; Lei, J.Y.; Chen, Y.; Zhu, R.Y.; Gong, X.H.; Ma, X. [Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Pharmaceutical Sciences, Jiangnan University, 1800 Lihu Rd., Wuxi, Jiangsu 214122 (China); Jin, J., E-mail: jinjian31@126.com [Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Pharmaceutical Sciences, Jiangnan University, 1800 Lihu Rd., Wuxi, Jiangsu 214122 (China)

2013-06-14

Highlights: •rhddADAM15 inhibited the proliferation and migration of Bel-7402 cells. •rhddADAM15 inhibited growth and metastasis of Bel-7402 cells in zebrafish xenograft. •rhddADAM15 induced apoptosis in Bel-7402 cells and somatic cells of zebrafish. •Cell-cycle in Bel-7402 cells showed a partial G{sub 2}/S arrest. •Activity of caspases 8, 9 and 3 was increased in rhddADAM15-treated Bel-7402 cells. -- Abstract: ADAM15 (A Disintegrin And Metalloproteinase 15), a transmembrane protein containing seven domains, interacts with some integrins via its disintegrin domain and overexpresses in many solid tumors. In this study, the effect of the recombinant human disintegrin domain (rhddADAM15) on the proliferation and migration of Bel-7402 cells was evaluated in vitro and in vivo in zebrafish xenografts. rhddADAM15 (4 μM) severely inhibited the proliferation and migration of Bel-7402 cells, inducing a partial G{sub 2}/S arrest and morphological nucleus changes of apoptosis. Moreover, the activity of caspases 8, 9 and 3 in Bel-7402 cells was increased. In addition, the zebrafish was used as a model for apoptosis-induction and tumor-xenograft. rhddADAM15 (1 pM) inhibited the growth and metastasis of Bel-7402 cell xenografts in zebrafish and a lower concentration (0.1 pM) induced severe apoptosis in the somatic cells of zebrafish. In conclusion, our data identified rhddADAM15 as a potent inhibitor of tumor growth and metastasis, making it a promising tool for use in anticancer treatment.

Overexpression of soluble ADAM33 promotes a hypercontractile phenotype of the airway smooth muscle cell in rat

Energy Technology Data Exchange (ETDEWEB)

Duan, Yiyuan; Long, Jiaoyue; Chen, Jun; Jiang, Xuemei; Zhu, Jian; Jin, Yang; Lin, Feng; Zhong, Jun; Xu, Rong [Key Laboratory of Biorheological Science and Technology, Ministry of Education, and Bioengineering College, Chongqing University, Shapingba, Chongqing 400030 (China); Mao, Lizheng [Jiangsu Asialand Biomed-Technology Co. Ltd., Changzhou, Jiangsu 213164 (China); Deng, Linhong, E-mail: dlh@cczu.edu.cn [Key Laboratory of Biorheological Science and Technology, Ministry of Education, and Bioengineering College, Chongqing University, Shapingba, Chongqing 400030 (China); Changzhou Key Laboratory of Respiratory Medical Engineering, Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou, Jiangsu 213164 (China)

2016-11-15

A disintegrin and metalloproteinase 33 (ADAM33) has been identified as a susceptibility gene for asthma, but details of the causality are not fully understood. We hypothesize that soluble ADAM33 (sADAM33) overexpression can alter the mechanical behaviors of airway smooth muscle cells (ASMCs) via regulation of the cell's contractile phenotype, and thus contributes to airway hyperresponsiveness (AHR) in asthma. To test this hypothesis, we either overexpressed or knocked down the sADAM33 in rat ASMCs by transfecting the cells with sADAM33 coding sequence or a small interfering RNA (siRNA) that specifically targets the ADAM33 disintegrin domain, and subsequently assessed the cells for stiffness, contractility and traction force, together with the expression level of contractile and proliferative phenotype markers. We also investigated whether these changes were dependent on Rho/ROCK pathway by culturing the ASMCs either in the absence or presence of ROCK inhibitor (H1152). The results showed that the ASMCs with sADAM33 overexpression were stiffer and more contractile, generated greater traction force, exhibited increased expression levels of contractile phenotype markers and markedly enhanced Rho activation. Furthermore these changes were largely attenuated when the cells were cultured in the presence of H-1152. However, the knock-down of ADAM33 seemed insufficient to influence majority of the mechanical behaviors of the ASMCs. Taken together, we demonstrated that sADAM33 overexpression altered the mechanical behaviors of ASMCs in vitro, which was most likely by promoting a hypercontractile phenotype transition of ASMCs through Rho/ROCK pathway. This revelation may establish the previously missing link between ADAM33 expression and AHR, and also provide useful insight for targeting sADAM33 in asthma prevention and therapy. - Highlights: • sADAM33 overexpression enhances the stiffness, traction force and contractility of ASMCs. • sADAM33 overexpression promotes

Overexpression of soluble ADAM33 promotes a hypercontractile phenotype of the airway smooth muscle cell in rat

International Nuclear Information System (INIS)

Duan, Yiyuan; Long, Jiaoyue; Chen, Jun; Jiang, Xuemei; Zhu, Jian; Jin, Yang; Lin, Feng; Zhong, Jun; Xu, Rong; Mao, Lizheng; Deng, Linhong

2016-01-01

A disintegrin and metalloproteinase 33 (ADAM33) has been identified as a susceptibility gene for asthma, but details of the causality are not fully understood. We hypothesize that soluble ADAM33 (sADAM33) overexpression can alter the mechanical behaviors of airway smooth muscle cells (ASMCs) via regulation of the cell's contractile phenotype, and thus contributes to airway hyperresponsiveness (AHR) in asthma. To test this hypothesis, we either overexpressed or knocked down the sADAM33 in rat ASMCs by transfecting the cells with sADAM33 coding sequence or a small interfering RNA (siRNA) that specifically targets the ADAM33 disintegrin domain, and subsequently assessed the cells for stiffness, contractility and traction force, together with the expression level of contractile and proliferative phenotype markers. We also investigated whether these changes were dependent on Rho/ROCK pathway by culturing the ASMCs either in the absence or presence of ROCK inhibitor (H1152). The results showed that the ASMCs with sADAM33 overexpression were stiffer and more contractile, generated greater traction force, exhibited increased expression levels of contractile phenotype markers and markedly enhanced Rho activation. Furthermore these changes were largely attenuated when the cells were cultured in the presence of H-1152. However, the knock-down of ADAM33 seemed insufficient to influence majority of the mechanical behaviors of the ASMCs. Taken together, we demonstrated that sADAM33 overexpression altered the mechanical behaviors of ASMCs in vitro, which was most likely by promoting a hypercontractile phenotype transition of ASMCs through Rho/ROCK pathway. This revelation may establish the previously missing link between ADAM33 expression and AHR, and also provide useful insight for targeting sADAM33 in asthma prevention and therapy. - Highlights: • sADAM33 overexpression enhances the stiffness, traction force and contractility of ASMCs. • sADAM33 overexpression promotes a

Cut loose and run: The complex role of ADAM proteases during neural crest cell development.

Science.gov (United States)

Alfandari, Dominique; Taneyhill, Lisa A

2018-02-24

ADAM metalloproteases have been shown to play critical roles during development. In this review, we will describe functional evidence that implicates ADAM proteins during the genesis, migration and differentiation of neural crest cells. We will restrict our analysis to the transmembrane ADAMs as other reviews have addressed the role of extracellular metalloproteases (Christian et al. [2013] Critical Reviews in Biochemistry and Molecular Biology 48:544-560). This review will describe advances that have been obtained mainly through the use of two vertebrate model systems, the frog, and avian embryos. The role of the principal substrates of ADAMs, the cadherins, has been extensively described in other reviews, most recently in (Cousin [1997] Mechanisms of Development 148:79-88; Taneyhill and Schiffmacher [2017] Genesis, 55). The function of ADAMs in the migration of other cell types, including the immune system, wound healing and cancer has been described previously in (Dreymueller et al. [2017] Mediators of Inflammation 2017: 9621724). Our goal is to illustrate both the importance of ADAMs in controlling neural crest behavior and how neural crest cells have helped us understand the molecular interactions, substrates, and functions of ADAM proteins in vivo. © 2018 Wiley Periodicals, Inc.

A Four-Step Block Hybrid Adams-Moulton Methods For The Solution ...

African Journals Online (AJOL)

This paper examines application of the Adam-Moulton's Method and proposes a modified self-starting continuous formula Called hybrid Adams-Moulton methods for the case k=4. It allows evaluation at both grid and off grid points to obtain the discrete schemes used in the block methods. The order, error constant and ...

TGF{beta} induces proHB-EGF shedding and EGFR transactivation through ADAM activation in gastric cancer cells

Energy Technology Data Exchange (ETDEWEB)

Ebi, Masahide [Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya (Japan); Kataoka, Hiromi, E-mail: hkataoka@med.nagoya-cu.ac.jp [Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya (Japan); Shimura, Takaya; Kubota, Eiji; Hirata, Yoshikazu; Mizushima, Takashi; Mizoshita, Tsutomu; Tanaka, Mamoru; Mabuchi, Motoshi; Tsukamoto, Hironobu; Tanida, Satoshi; Kamiya, Takeshi [Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya (Japan); Higashiyama, Shigeki [Department of Biochemistry and Molecular Genetics, Ehime University Graduate School of Medicine, Ehime (Japan); Joh, Takashi [Department of Gastroenterology and Metabolism, Nagoya City University Graduate School of Medical Sciences, Nagoya (Japan)

2010-11-19

Research highlights: {yields} TGF{beta} induces EGFR transactivation through proHB-EGF shedding by activated ADAM members in gastric cancer cells. {yields} TGF{beta} induces nuclear translocation of HB-EGF-CTF cleaved by ADAM members. {yields} TGF{beta} enhances cell growth by EGFR transactivation and HB-EGF-CTF nuclear translocation and ADAM inhibitors block these effects. {yields} Silencing of ADAM17 also blocks EGFR transactivation, HB-EGF-CTF nuclear translocation and cancer cell growth by TGF{beta}. {yields} ADAM17 may play a crucial role in this TGF{beta}-HB-EGF signal transduction. -- Abstract: Background and aims: Transforming growth factor-beta (TGF{beta}) is known to potently inhibit cell growth. Loss of responsiveness to TGF{beta} inhibition on cell growth is a hallmark of many types of cancer, yet its mechanism is not fully understood. Membrane-anchored heparin-binding EGF-like growth factor (proHB-EGF) ectodomain is cleaved by a disintegrin and metalloproteinase (ADAM) members and is implicated in epidermal growth factor receptor (EGFR) transactivation. Recently, nuclear translocation of the C-terminal fragment (CTF) of pro-HB-EGF was found to induce cell growth. We investigated the association between TGF{beta} and HB-EGF signal transduction via ADAM activation. Materials and methods: The CCK-8 assay in two gastric cancer cell lines was used to determine the effect for cell growth by TGF{beta}. The effect of two ADAM inhibitors was also evaluated. Induction of EGFR phosphorylation by TGF{beta} was analyzed and the effect of the ADAM inhibitors was also examined. Nuclear translocation of HB-EGF-CTF by shedding through ADAM activated by TGF{beta} was also analyzed. EGFR transactivation, HB-EGF-CTF nuclear translocation, and cell growth were examined under the condition of ADAM17 knockdown. Result: TGF{beta}-induced EGFR phosphorylation of which ADAM inhibitors were able to inhibit. TGF{beta} induced shedding of proHB-EGF allowing HB-EGF-CTF to

Investigating the Impact of the Cisco 21st Century Schools Initiative on Forrest County School District. Summative Report

Science.gov (United States)

Ba, Harouna; Meade, Terri; Pierson, Elizabeth; Ferguson, Camille; Roy, Amanda; Williams, Hakim

2009-01-01

Located in southern Mississippi, the Forrest County School District (FCSD) consists of six schools: three K-6 elementary schools, two K-8 elementary-middle schools, and one high school (grades 9-12), all of which have been involved in the Cisco Initiative since its inception. The district employed 16 administrators, 7 technology staff members, and…

Cosmosiin Increases ADAM10 Expression via Mechanisms Involving 5’UTR and PI3K Signaling

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Zhuo Min

2018-06-01

Full Text Available The α-secretase “a disintegrin and metalloproteinase domain-containing protein” (ADAM10 is involved in the processing of amyloid precursor protein (APP. Upregulation of ADAM10 precludes the generation of neurotoxic β-amyloid protein (Aβ and represents a plausible therapeutic strategy for Alzheimer’s disease (AD. In this study, we explored compounds that can potentially promote the expression of ADAM10. Therefore, we performed high-throughput small-molecule screening in SH-SY5Y (human neuroblastoma cells that stably express a luciferase reporter gene driven by the ADAM10 promoter, including a portion of its 5’-untranslated region (5’UTR. This has led to the discovery of cosmosiin (apigenin 7-O-β-glucoside. Here, we report that in human cell lines (SH-SY5Y and HEK293, cosmosiin proportionally increased the levels of the immature and mature forms of the ADAM10 protein without altering its mRNA level. This effect was attenuated by translation inhibitors or by deleting the 5’UTR of ADAM10, suggesting that a translational mechanism was responsible for the increased levels of ADAM10. Luciferase deletion assays revealed that the first 144 nucleotides of the 5’UTR were necessary for mediating the cosmosiin-induced enhancement of ADAM10 expression in SH-SY5Y cells. Cosmosiin failed to increase the levels of the ADAM10 protein in murine cells, which lack native expression of the ADAM10 transcript containing the identified 5’UTR element. The potential signaling pathway may involve phosphatidylinositide 3-kinase (PI3K because pharmacological inhibition of PI3K attenuated the effect of cosmosiin on the expression of the ADAM10 protein. Finally, cosmosiin attenuated Aβ generation because the levels of Aβ40/42 in HEK-APP cells were significantly reduced after cosmosiin treatment. Collectively, we found that the first 144 nucleotides of the ADAM10 5’UTR, and PI3K signaling, are involved in cosmosiin-induced enhancement of the expression

AgraPure Mississippi Biomass Project

Energy Technology Data Exchange (ETDEWEB)

Blackwell,D.A; Broadhead, L.W.; Harrell, W.J.

2006-03-31

The AgraPure Mississippi Biomass project was a congressionally directed project, initiated to study the utilization of Mississippi agricultural byproducts and waste products in the production of bio-energy and to determine the feasibility of commercialization of these agricultural byproducts and waste products as feedstocks in the production of energy. The final products from this project were two business plans; one for a Thermal plant, and one for a Biodiesel/Ethanol plant. Agricultural waste fired steam and electrical generating plants and biodiesel plants were deemed the best prospects for developing commercially viable industries. Additionally, oil extraction methods were studied, both traditional and two novel techniques, and incorporated into the development plans. Mississippi produced crop and animal waste biomasses were analyzed for use as raw materials for both industries. The relevant factors, availability, costs, transportation, storage, location, and energetic value criteria were considered. Since feedstock accounts for more than 70 percent of the total cost of producing biodiesel, any local advantages are considered extremely important in developing this particular industry. The same factors must be evaluated in assessing the prospects of commercial operation of a steam and electrical generation plant. Additionally, the access to the markets for electricity is more limited, regulated and tightly controlled than the liquid fuel markets. Domestically produced biofuels, both biodiesel and ethanol, are gaining more attention and popularity with the consuming public as prices rise and supplies of foreign crude become less secure. Biodiesel requires no major modifications to existing diesel engines or supply chain and offers significant environmental benefits. Currently the biodiesel industry requires Federal and State incentives to allow the industry to develop and become self-sustaining. Mississippi has available the necessary feedstocks and is

Microautoradiography of [{sup 123}I]ADAM in mice treated with fluoxetine and serotonin reuptake inhibitors

Energy Technology Data Exchange (ETDEWEB)

Ye, X.-X.; Chen, J.-C.; Liu, R.-S.; Wey, S.-P.; Lee, J.-S.; Chen, C.-C.; Fu, Y.-K.; Ting, Gann; Hwang, J.-J. E-mail: jjhwang@ym.edu.tw

2004-07-01

A radiopharmaceutical, {sup 123}I-labeled 2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine ([{sup 123}I]ADAM), has been developed recently for evaluation of how serotonin transporters (SERT) function in the brain. However, the detailed biodistribution and specific binding in certain brain areas are not well investigated. In this study, both phosphor plate imaging and microautoradiography were applied to explore the binding characteristics of [{sup 123}I]ADAM in SERT neurons. The effect of two psychotropics and one narcotic on the binding of [{sup 123}I]ADAM to SERT was also studied. Fluoxetine and desipramine, both are psychotropics and specific SERT ligands and decreased the affinity of [{sup 123}I]ADAM, while p-chloroamphetamine (PCA), a narcotic, destroyed most of serotonergic neurons, as well as reducing the concentration of serotonin and the number of SERT in the brain as shown by the biodistribution of [{sup 123}I]ADAM. Significant and selective accumulation of [{sup 123}I]ADAM in the areas from midbrain to brain stem in normal mice with maximum target-to-background ratio was found at 90 minutes postinjection. A rapid clearance of [{sup 131}I]ADAM at 120 minutes postinjection was found in the CA1, CA3 and ThN brain areas. In addition, the inhibition effect on binding ability of [{sup 123}I]ADAM to SERT by the psychotropics and the narcotic was found to have the order of: PCA > fluoxetine > desipramine.

ADAM17 is associated with EMMPRIN and predicts poor prognosis in patients with uterine cervical carcinoma.

Science.gov (United States)

Xu, Qin; Ying, Mingang; Chen, Guilin; Lin, Ang; Xie, Yunqing; Ohara, Noriyuki; Zhou, Dongmei

2014-08-01

Metalloproteinase activities of a disintegrin and metalloproteinase 17 (ADAM17), amphiregulin (AREG), extracellular matrix metalloproteinase inducer (EMMPRIN), and matrix metalloproteinases (MMPs) are involved in tumor biology. In patients with uterine cervical carcinoma, the expression and prognostic significance of ADAM17 remain to be fully elucidated. The expression of ADAM17, AREG, EMMPRIN, phospho-epidermal growth factor receptor (p-EGFR), phospho-extracellular signal-regulated kinase (p-ERK), MMP-2, and MMP-9 was assessed by immunohistochemistry and/or Western blotting from cervical carcinoma cell lines, SiHa and HeLa cells, and cervical carcinoma tissues. AREG activity was measured by ELISA assay. The correlation of ADAM17, AREG, EMMPRIN, and MMP-9 expression with patients' survival rates was assessed by Kaplan-Meier and Cox regression analyses. RNA interference (RNAi) experiment was performed using small interfering mRNA to ADAM17 and EMMPRIN. ADAM17, EMMPRIN, and MMP-9 protein content was overexpressed in cervical carcinoma tissues compared with normal cervical tissues (P EMMPRIN, and MMP-9 was significantly associated with stages, lymph node metastasis, differentiation, and parametrium invasion (P EMMPRIN, and MMP-9 was significantly correlated with short progression-free survival and overall survival (P EMMPRIN, p-EGFR, p-ERK, MMP-2, and MMP-9 proteins in SiHa and HeLa cells. ELISA assay revealed that AREG activity was stimulated by ADAM17 and was reversed by ADAM17 RNAi in SiHa and HeLa cells. Our data suggest that the increased expression of ADAM17 in cervical cancer is significantly associated with aggressive progression and poor prognosis. ADAM17 may be a molecular marker for predicting the progression and prognosis in cervical cancer.

Eclipsing Aestheticism: Western Landscape Photography After Ansel Adams

OpenAIRE

Dennis, Kelly

2015-01-01

Bien que l’héritage photographique d’Ansel Adams (1902-84) reste incontestable dans la culture de masse, dans les musées et parmi les collectionneurs, la nature de cet héritage fait débat parmi les artistes contemporains, les chercheurs et les théoriciens de la photographie. Pour certains, à la fin du 20ème siècle, les paysages typiques de Adams représentant l’Ouest américain au milieu du siècle désignaient une connivence secrète avec l’expansion américaine vers l’ouest durant la guerre froid...

The Mississippi Years (1969-1974)

Science.gov (United States)

Agras, W. Stewart

2012-01-01

The 4 years that Michel Hersen spent at the University of Mississippi Medical Center (1970-1974) are described in this article from the viewpoint of his place in the history of the development of behavior analysis and therapy. The Department of Psychiatry at the University of Mississippi Medical Center became a leader in enhancing the role of…

Targeting ADAM12 in human disease: head, body or tail?

DEFF Research Database (Denmark)

Jacobsen, J; Wewer, U M

2009-01-01

) and insulin-like growth factor receptor signaling. The body of the protein (consisting of the disintegrin, cysteine-rich, and EGF-like domains) is involved in contacts with the extracellular matrix and other cells through interactions with integrins and syndecans. Finally, the tail of the protein (consisting......ADAM12/meltrin alpha is a type I transmembrane multidomain protein involved in tumor progression and other severe diseases, including osteoarthritis, and as such could be considered as a potential drug target. In addition to protease activity, ADAM12 possesses cell binding and cell signaling...... properties. This functional trinity is reflected in the structure of ADAM12, which can be divided into head, body, and tail. The head of the protein (consisting of the pro and catalytic domains) mediates processing of growth factors and cytokines and has been implicated in epidermal growth factor (EGF...

Dietary acculturation of Hispanic immigrants in Mississippi Aculturación alimentaria de inmigrantes hispanos en Mississippi

Directory of Open Access Journals (Sweden)

Virginia B. Gray

2005-10-01

Full Text Available OBJECTIVE: Assisting Hispanic immigrants in making culturally acceptable food choices may affect their health for generations. As a relatively new enclave of Hispanics, Scott County, Mississippi, was chosen to study dietary acculturation and health concerns of immigrants. MATERIAL AND METHODS: The research method consisted of interviews with community representatives (N=11, a focus group (N=6, and interviews with Hispanic immigrants (N=18. RESULTS: Community representatives mentioned availability influenced immigrants' food choices and suggested promoting cultural awareness and offering nutrition classes on local ingredients. Food cost, health concepts, food selection, and eating habits of children were salient themes from the focus group and interviews with Hispanics. Hispanic participants mentioned long work hours affect food selection and that US produce lacks freshness and flavor. CONCLUSIONS: Results indicate that an intervention must be formulated that preserves healthful dietary practices and minimizes the negative health aspects of acculturation to the "American diet."OBJETIVO: Ayudar a inmigrantes hispanos en la elección de una dieta culturalmente aceptable puede incidir sobre su salud por generaciones. Para estudiar la relación entre aculturación alimentaria y salud en los inmigrantes, se escogió Scott County, Mississippi, un enclave relativamente nuevo de inmigrantes hispanos en Estados Unidos de América (EUA. MATERIAL Y MÉTODOS: El método de investigación consistió en entrevistas con representantes de la comunidad (N=11, un grupo focal (N=6 e inmigrantes hispanos (N=18. RESULTADOS: Representantes de la comunidad mencionaron que lo que influye en la elección de sus alimentos es la disponibilidad de éstos; asimismo sugirieron la organización de actividades para conocer diferentes culturas, al igual que clases de nutrición para aprender cómo utilizar ingredientes locales. Cinco fueron los temas más relevantes que se

Selective inhibition of ADAM12 catalytic activity through engineering of tissue inhibitor of metalloproteinase 2 (TIMP-2)

DEFF Research Database (Denmark)

Kveiborg, Marie; Jacobsen, Jonas; Lee, Meng-Huee

2010-01-01

activity may be of great value therapeutically and as an investigative tool to elucidate its mechanisms of action. We have previously reported the inhibitory profile of TIMPs (tissue inhibitor of metalloproteinases) against ADAM12, demonstrating in addition to TIMP-3, a unique ADAM-inhibitory activity...... activity of TIMPs against the transmembrane ADAM12-L (full-length ADAM12), verifying the distinctive inhibitory abilities of N-TIMP-2 and engineered N-TIMP-2 mutants in a cellular environment. Taken together, our findings support the idea that a distinctive ADAM12 inhibitor with future therapeutic...

Investigating the Impact of the Cisco 21st Century Schools Initiative on Forrest County Agricultural High School. Summative Report

Science.gov (United States)

Ba, Harouna; Meade, Terri; Pierson, Elizabeth; Ferguson, Camille; Roy, Amanda; Williams, Hakim

2009-01-01

Forrest County Agricultural High School (FCAHS) is located in Brooklyn, a small rural town in southern Mississippi and part of the Hattiesburg Metropolitan Statistical Area. Unlike the other schools that participated in the Cisco 21S initiative, FCAHS is not part of a larger school district. Therefore, the unit of analysis throughout this summary…

Adam Smith's bougeois virtues in competition

NARCIS (Netherlands)

Wells, T.; Graafland, J.J.

2012-01-01

Whether or not capitalism is compatible with ethics is a long standing dispute. We take up an approach to virtue ethics inspired by Adam Smith and consider how market competition influences the virtues most associated with modern commercial society. Up to a point, competition nurtures and supports

Assessing Hurricane Katrina Damage to the Mississippi Gulf Coast Using IKONOS Imagery

Science.gov (United States)

Spruce, Joseph; McKellip, Rodney

2006-01-01

Hurricane Katrina hit southeastern Louisiana and the Mississippi Gulf Coast as a Category 3 hurricane with storm surges as high as 9 m. Katrina devastated several coastal towns by destroying or severely damaging hundreds of homes. Several Federal agencies are assessing storm impacts and assisting recovery using high-spatial-resolution remotely sensed data from satellite and airborne platforms. High-quality IKONOS satellite imagery was collected on September 2, 2005, over southwestern Mississippi. Pan-sharpened IKONOS multispectral data and ERDAS IMAGINE software were used to classify post-storm land cover for coastal Hancock and Harrison Counties. This classification included a storm debris category of interest to FEMA for disaster mitigation. The classification resulted from combining traditional unsupervised and supervised classification techniques. Higher spatial resolution aerial and handheld photography were used as reference data. Results suggest that traditional classification techniques and IKONOS data can map wood-dominated storm debris in open areas if relevant training areas are used to develop the unsupervised classification signatures. IKONOS data also enabled other hurricane damage assessment, such as flood-deposited mud on lawns and vegetation foliage loss from the storm. IKONOS data has also aided regional Katrina vegetation damage surveys from multidate Land Remote Sensing Satellite and Moderate Resolution Imaging Spectroradiometer data.

MBS Analysis Of Kinetic Structures Using ADAMS

DEFF Research Database (Denmark)

Kirkegaard, Poul Henning; Nielsen, Søren R.K.

2009-01-01

The present paper considers multibody system (MBS) analysis of kinetic structures using the software package ADAMS. Deployable, foldable, expandable and reconfigurable kinetic structures can provide a change in the geometric morphology of the envelope by contributing to making it adaptable to e.......g. changing external climate factors, in order to improve the indoor climate performance of the building. The derivation of equations of motion for such spatial mechanical systems is a challenging issue in scientific community. However, with new symbolic tools one can automatically derive equations in so......-called multibody system (MBS) formalism. The present paper considers MBS modeling of kinetic architectural structures using the software packages ADAMS. As a result, it is found that symbolic MBS simulation tools facilitate a useful evaluation environment for MBS users during a design phase of responsive kinetic...

The role of metalloproteinase ADAM17 in regulating ICOS ligand-mediated humoral immune responses

DEFF Research Database (Denmark)

Marczynska, Joanna; Ozga, Aleksandra; Wlodarczyk, Agnieszka

2014-01-01

results in spleen and lymph node enlargement, as well as increased levels of Ag-specific class-switched Ig production following immunization with OVA together with anti-CD40 mAbs and polyinosinic-polycytidylic acid. Moreover, we demonstrate that the costimulatory ligand ICOS ligand (ICOSL) is selectively...... downregulated on the surface of B cells in an ADAM17-specific manner, although it is not proteolitically processed by recombinant ADAM17 in vitro. Finally, we show that higher cell surface levels of ICOSL in ADAM17(ex/ex) mice may contribute to the development of excessive Ab responses. Therefore, our data...... suggest a functional link between ADAM17 and ICOSL in controlling adaptive immune responses....

ADAM-17 is a poor prognostic indicator for patients with hilar cholangiocarcinoma and is regulated by FoxM1.

Science.gov (United States)

Jiao, Xiaodong; Yu, Wenlong; Qian, Jianxin; Chen, Ying; Wei, Peilian; Fang, Wenzheng; Yu, Guanzhen

2018-05-18

A-disintegrin and metalloproteinases (ADAMs) are members of a family of multidomain transmembrane and secreted proteins. Specific ADAMs are upregulated in human cancers and correlated with tumor progression and poor outcome, but rarely studied in human hilar cholangiocarcinoma (HC). This study aimed to explore the expression profiles of ADAMs and their potential underlying mechanisms promoting cancer progression. mRNA expression of ADAM-9, - 10, - 11, - 12, - 15, - 17, - 28, and - 33 was analyzed in human hilar cholangiocarcinoma (HC) samples. Immunohistochemical (IHC) analysis was used to detect the expression of ADAM-10, - 17, - 28, and FoxM1 in HC. The regulation of ADAM-17 by FoxM1 and their functional study was investigated in vivo and in vitro. ADAM-10, - 17, and - 28 were upregulated in tumors compared with matched non-cancerous tissues. IHC analysis revealed increased expression of ADAM-10, - 17, and - 28 in HC cells, and ADAM17 seems to be an independent prognostic factor. ADAM-17 is regulated by FoxM1. A decrease in the expression of ADAM-17 by silencing FoxM1 led to an inhibition of cell proliferation, tumor growth, and the production of tumor necrosis factor α. IHC analysis showed co-expression of FoxM1 and ADAM-17 in HC specimens. The findings of the present study show an important role of the cross-talk among FoxM1, ADAM-17, and TNFa in HC development and progression.

An Adamic incarnational Christological framework as a theological approach for African contextual ministry

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Magezi, Vhumani

2016-12-01

Full Text Available Many African Christian thinkers and writers are responding to the foreignness of Christ in African Christianity by treating Christ under the traditional African ancestral category. However, it is our contention that the designation of the ancestral category to Christ has a tendency of diminishing the actuality of Christ as God incarnate and encouraging syncretism in African Christianity. Given this, this paper proposes and formulates an Adamic incarnational Christological model as an alternative response to the foreignness of Christ in African Christianity. In employing the anhypostastic and enhypostastic principles, we demonstrate that Jesus Christ is not a foreigner to African Christians, since the human nature he assumed in the incarnation is a general human nature which embraces all humankind. In establishing the Adam-Christ relationship in Romans 5:12-21 and 1 Corinthians 15:21-22, we advance Adam as a biblical-theological category in enhancing the relevance of Christ to Africans. It is from this perspective that our Adamic incarnational Christological model proposes that in the incarnation, God in Christ fully identified with all mankind as the New Adam, acting from the ontological depth of his divine-human existence to save African Christians from sin and all its consequences, including death and opposing spiritual forces. Thus, our own model underscores the relevance of Christ to African Christians by emphasizing Christs complete solidarity with all humanity as the New Adam.

Surface expression and limited proteolysis of ADAM10 are increased by a dominant negative inhibitor of dynamin

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Slack Barbara E

2011-05-01

Full Text Available Abstract Background The amyloid precursor protein (APP is cleaved by β- and γ-secretases to generate toxic amyloid β (Aβ peptides. Alternatively, α-secretases cleave APP within the Aβ domain, precluding Aβ formation and releasing the soluble ectodomain, sAPPα. We previously showed that inhibition of the GTPase dynamin reduced APP internalization and increased release of sAPPα, apparently by prolonging the interaction between APP and α-secretases at the plasma membrane. This was accompanied by a reduction in Aβ generation. In the present study, we investigated whether surface expression of the α-secretase ADAM (a disintegrin and metalloprotease10 is also regulated by dynamin-dependent endocytosis. Results Transfection of human embryonic kidney (HEK cells stably expressing M3 muscarinic receptors with a dominant negative dynamin I mutant (dyn I K44A, increased surface expression of both immature, and mature, catalytically active forms of co-expressed ADAM10. Surface levels of ADAM10 were unaffected by activation of protein kinase C (PKC or M3 receptors, indicating that receptor-coupled shedding of the ADAM substrate APP is unlikely to be mediated by inhibition of ADAM10 endocytosis in this cell line. Dyn I K44A strongly increased the formation of a C-terminal fragment of ADAM10, consistent with earlier reports that the ADAM10 ectodomain is itself a target for sheddases. The abundance of this fragment was increased in the presence of a γ-secretase inhibitor, but was not affected by M3 receptor activation. The dynamin mutant did not affect the distribution of ADAM10 and its C-terminal fragment between raft and non-raft membrane compartments. Conclusions Surface expression and limited proteolysis of ADAM10 are regulated by dynamin-dependent endocytosis, but are unaffected by activation of signaling pathways that upregulate shedding of ADAM substrates such as APP. Modulation of ADAM10 internalization could affect cellular behavior in two

Adam Podin ja pan-evangeelne vaimulaad / Toivo Pilli

Index Scriptorium Estoniae

Pilli, Toivo, 1962-

2013-01-01

Adam Podini elust ja tööst: Keila baptistikoguduse vaimulikuna, vanglamisjonäri ja pidalitõbiste abistajana, baptistide teoloogilise seminari direktorina, Evangeelse Alliansi kontaktisikuna Eestis

Association between ADAM metallopeptidase domain 33 gene polymorphism and risk of childhood asthma: a meta-analysis.

Science.gov (United States)

Sun, F J; Zou, L Y; Tong, D M; Lu, X Y; Li, J; Deng, C B

2017-08-31

This study aimed to investigate the association between ADAM metallopeptidase domain 33 (ADAM33) gene polymorphisms and the risk of childhood asthma. The relevant studies about the relationship between ADAM33 gene polymorphisms and childhood asthma were searched from electronic databases and the deadline of retrieval was May 2016. The single nucleotide polymorphisms (SNPs) of ADAM33 (rs511898, rs2280092, rs3918396, rs528557, rs2853209, rs44707, rs2280091 and rs2280089) were analyzed based on several models including the allele, codominant, recessive and dominant models. The results showed that the ADAM33 rs2280091 polymorphism in all four genetic models was associated with an increased risk of childhood asthma. Positive associations were also found between the polymorphisms rs2280090, rs2787094, rs44707 and rs528557 and childhood asthma in some genetic models. This meta-analysis suggested that ADAM33 polymorphisms rs2280091, rs2280090, rs2787094, rs44707 and rs528557 were significantly associated with a high risk of childhood asthma.

77 FR 58056 - Mississippi Regulatory Program

Science.gov (United States)

2012-09-19

... its program to be no less effective than the Federal regulations and to improve operational efficiency. This document gives the times and locations of the Mississippi program and this proposed amendment to... hours at the following location: Mississippi Office of Geology, Department of Environmental Quality, 700...

78 FR 64397 - Mississippi Regulatory Program

Science.gov (United States)

2013-10-29

...'' and ``Violation''; and revised the definitions for ``Applicant Violator System or AVS''; ``Knowing or... applicant's information into the Applicant Violator System (AVS). We find that Mississippi's new language is... AVS. We find that these revisions allow Mississippi to fully meet the Federal requirements of 30 CFR...

ADAM: A computer program to simulate selective-breeding schemes for animals

DEFF Research Database (Denmark)

Pedersen, L D; Sørensen, A C; Henryon, M

2009-01-01

ADAM is a computer program that models selective breeding schemes for animals using stochastic simulation. The program simulates a population of animals and traces the genetic changes in the population under different selective breeding scenarios. It caters to different population structures......, genetic models, selection strategies, and mating designs. ADAM can be used to evaluate breeding schemes and generate genetic data to test statistical tools...

A substrate-optimized electrophoretic mobility shift assay for ADAM12

DEFF Research Database (Denmark)

Kotzsch, Alexander; Skovgaard, Tine; Buus, Uwe

2014-01-01

long been investigated as pharmaceutical drug targets; however, due to lack of potency and in vivo side effects, none of the small-molecule inhibitors discovered so far has made it beyond clinical testing. Ongoing research on novel selective inhibitors of ADAMs requires reliable biochemical assays...... to validate molecular probes from large-scale screening efforts. Here we describe an electrophoretic mobility shift assay for ADAM12 based on the identification of an optimized peptide substrate that is characterized by excellent performance and reproducibility....

IL-1beta signals through the EGF receptor and activates Egr-1 through MMP-ADAM.

Directory of Open Access Journals (Sweden)

Estella Sanchez-Guerrero

Full Text Available The immediate-early gene Egr-1 controls the inducible expression of many genes implicated in the pathogenesis of a range of vascular disorders, yet our understanding of the mechanisms controlling the rapid expression of this prototypic zinc finger transcription factor is poor. Here we show that Egr-1 expression induced by IL-1beta is dependent on metalloproteinases (MMP and a disintegrin and a metalloproteinase (ADAM. Pharmacologic MMP/ADAM inhibitors and siRNA knockdown prevent IL-1beta induction of Egr-1. Further, IL-1beta activates Egr-1 via the epidermal growth factor receptor (EGFR. This is blocked by EGFR tyrosine kinase inhibition and EGFR knockdown. IL-1beta induction of Egr-1 expression is reduced in murine embryonic fibroblasts (mEFs deficient in ADAM17 despite unbiased expression of EGFR and IL-1RI in ADAM17-deficient and wild-type mEFs. Finally, we show that IL-1beta-inducible wound repair after mechanical injury requires both EGFR and MMP/ADAM. This study reports for the first time that Egr-1 induction by IL-1beta involves EGFR and MMP/ADAM-dependent EGFR phosphorylation.

ADAM12 overexpression does not improve outcome in mice with laminin alpha2-deficient muscular dystrophy

DEFF Research Database (Denmark)

Guo, Ling T; Shelton, G Diane; Wewer, Ulla M

2005-01-01

We have recently shown that overexpression of ADAM12 results in increased muscle regeneration and significantly reduced pathology in mdx, dystrophin deficient mice. In the present study, we tested the effect of overexpressing ADAM12 in dy(W) laminin-deficient mice. dy mice have a very severe...... clinical phenotype and would be expected to benefit greatly from enhanced regeneration. We found that dy(W) mice overexpressing ADAM12 indeed have increased muscle regeneration, as evidenced by increased numbers of muscle fibers expressing fetal myosin. However, overexpression of ADAM12 had no significant...

Kemper County IGCC (tm) Project Preliminary Public Design Report

Energy Technology Data Exchange (ETDEWEB)

Nelson, Matt; Rush, Randall; Madden, Diane; Pinkston, Tim; Lunsford, Landon

2012-07-01

The Kemper County IGCC Project is an advanced coal technology project that is being developed by Mississippi Power Company (MPC). The project is a lignite-fueled 2-on-1 Integrated Gasification Combined-Cycle (IGCC) facility incorporating the air-blown Transport Integrated Gasification (TRIG™) technology jointly developed by Southern Company; Kellogg, Brown, and Root (KBR); and the United States Department of Energy (DOE) at the Power Systems Development Facility (PSDF) in Wilsonville, Alabama. The estimated nameplate capacity of the plant will be 830 MW with a peak net output capability of 582 MW. As a result of advanced emissions control equipment, the facility will produce marketable byproducts of ammonia, sulfuric acid, and carbon dioxide. 65 percent of the carbon dioxide (CO{sub 2}) will be captured and used for enhanced oil recovery (EOR), making the Kemper County facility’s carbon emissions comparable to those of a natural-gas-fired combined cycle power plant. The commercial operation date (COD) of the Kemper County IGCC plant will be May 2014. This report describes the basic design and function of the plant as determined at the end of the Front End Engineering Design (FEED) phase of the project.

78 FR 10187 - Changes in Flood Hazard Determinations

Science.gov (United States)

2013-02-13

....com/ County (12-08- Fischer, 4430 South Adams index.php/colorado/ 0595P). Chairman, Adams County... Public Works http:// March 15, 2013 370498 Cornelius (12- Jeff Tarte, Department, 21445 www.bakeraecom...

2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM): an improved serotonin transporter ligand

International Nuclear Information System (INIS)

Oya, Shunichi; Choi, S.-R.; Hou, Catherine; Mu Mu; Kung, M.-P.; Acton, Paul D.; Siciliano, Michael; Kung, Hank F.

2000-01-01

Serotonin transporters (SERT) are target-sites for commonly used antidepressants, such as fluoxetine, paroxetine, sertraline, and so on. Imaging of these sites in the living human brain may provide an important tool to evaluate the mechanisms of action as well as to monitor the treatment of depressed patients. Synthesis and characterization of an improved SERT imaging agent, ADAM (2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine)(7) was achieved. The new compound, ADAM(7), displayed an extremely potent binding affinity toward SERT (K i =0.013 nM, in membrane preparations of LLC-PK 1 -cloned cell lines expressing the specific monoamine transporter). ADAM(7) also showed more than 1,000-fold selectivity for SERT over norepinephrine transporter (NET) and dopamine transporter (DAT) (K i =699 and 840 nM, for NET and DAT, respectively). The radiolabeled compound [ 125 I]ADAM(7) showed an excellent brain uptake in rats (1.41% dose at 2 min post intravenous [IV] injection), and consistently displayed the highest uptake (between 60-240 min post IV injection) in hypothalamus, a region with the highest density of SERT. The specific uptake of [ 125 I]ADAM(7) in the hypothalamus exhibited the highest target-to-nontarget ratio ([hypothalamus - cerebellum]/cerebellum was 3.97 at 120 min post IV injection). The preliminary imaging study of [ 123 I]ADAM in the brain of a baboon by single photon emission computed tomography (SPECT) at 180-240 min post IV injection indicated a specific uptake in midbrain region rich in SERT. These data suggest that the new ligand [ 123 I]ADAM(7) may be useful for SPECT imaging of SERT binding sites in the human brain

At læse Adam Smith er både befriende og irriterende

DEFF Research Database (Denmark)

Larsen, Steen Nepper

2014-01-01

Anmeldelse af Adam Smith: "Teorien om de moralske følelser", oversat af Claus Bratt Østergaard, udg. på Informations Forlag......Anmeldelse af Adam Smith: "Teorien om de moralske følelser", oversat af Claus Bratt Østergaard, udg. på Informations Forlag...

ADAM12 redistributes and activates MMP-14, resulting in gelatin degradation, reduced apoptosis and increased tumor growth

DEFF Research Database (Denmark)

Albrechtsen, Reidar; Kveiborg, Marie; Hansen, Dorte Stautz

2013-01-01

that there is a positive correlation between MMP-14 and ADAM12 expression in human breast cancer. We demonstrated that in 293-VnR and human breast cancer cells expressing ADAM12 at the cell surface, endogenous MMP-14 was recruited to the cell surface, resulting in its activation. Subsequent to this activation, gelatin......Matrix metalloproteinases (MMPs), in particular MMP-2, MMP-9 and MMP-14, play a key role in various aspects of cancer pathology. Likewise, ADAMs (a disintegrin and metalloproteinases), including ADAM12, are upregulated in malignant tumors and contribute to the pathology of cancers. Here, we show....... Furthermore, orthotopic implantation of ADAM12-expressing MCF7 cells in nude mice produced tumors with increased levels of activated MMP-14 and confirmed that ADAM12 protects tumor cells against apoptosis, leading to increased tumor progression. In conclusion, our data suggest that a ternary protein complex...

Dysregulation of the ADAM17/Notch signalling pathways in endometriosis: from oxidative stress to fibrosis.

Science.gov (United States)

González-Foruria, Iñaki; Santulli, Pietro; Chouzenoux, Sandrine; Carmona, Francisco; Chapron, Charles; Batteux, Frédéric

2017-07-01

Is oxidative stress associated with the A disintegrin and metalloproteases (ADAM) metallopeptidase domain 17 (ADAM17)/Notch signalling pathway and fibrosis in the development of endometriosis? Oxidative stress is correlated with hyperactivation of the ADAM17/Notch signalling pathway and a consequent increase in fibrosis in patients with endometriosis. It is nowadays accepted that oxidative stress plays an important role in the onset and progression of endometriosis. Oxidative stress is able to induce the synthesis of some members of the 'ADAM' family, such as ADAM17. ADAM17/Notch signalling is dysregulated in other profibrotic and inflammatory diseases. This was a prospective laboratory study conducted in a tertiary-care university hospital between January 2011 and April 2013. We investigated non-pregnant, younger than 42-year-old patients (n = 202) during surgery for a benign gynaecological condition. After complete surgical exploration of the abdominopelvic cavity, 121 women with histologically proven endometriosis and 81 endometriosis-free control women were enrolled. Peritoneal fluid (PF) samples were obtained from all the study participants during surgery in order to detect advanced oxidation protein products (AOPPs) and metalloproteinase activity of ADAM17. Stromal cells from endometrial specimens (n = 8) were obtained from endometrium of control patients (Cs), and from eutopic (Es) and ectopic (Ps) endometrium of patients with deep infiltrating endometriosis (DIE) (n = 8). ADAM17, Notch and the fibrosis markers α-smooth muscle actin (α-SMA) and type-I collagen were assessed using immunoblotting in all the endometrial samples obtained. Additionally, fibrosis was assessed after using Notch cleavage inhibitors (DAPT and FLI-06). Notch and fibrosis were also evaluated after stimulation of stromal endometrial cells with ADAM17 purified protein, increasing concentrations of H2O2 and primary cell culture supernatants. Patients with DIE presented higher PF AOPP

2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine (ADAM): an improved serotonin transporter ligand

Energy Technology Data Exchange (ETDEWEB)

Oya, Shunichi; Choi, S.-R.; Hou, Catherine; Mu Mu; Kung, M.-P.; Acton, Paul D.; Siciliano, Michael; Kung, Hank F. E-mail: kunghf@sunmac.spect.upenn.edu

2000-04-01

Serotonin transporters (SERT) are target-sites for commonly used antidepressants, such as fluoxetine, paroxetine, sertraline, and so on. Imaging of these sites in the living human brain may provide an important tool to evaluate the mechanisms of action as well as to monitor the treatment of depressed patients. Synthesis and characterization of an improved SERT imaging agent, ADAM (2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine)(7) was achieved. The new compound, ADAM(7), displayed an extremely potent binding affinity toward SERT (K{sub i}=0.013 nM, in membrane preparations of LLC-PK{sub 1}-cloned cell lines expressing the specific monoamine transporter). ADAM(7) also showed more than 1,000-fold selectivity for SERT over norepinephrine transporter (NET) and dopamine transporter (DAT) (K{sub i}=699 and 840 nM, for NET and DAT, respectively). The radiolabeled compound [{sup 125}I]ADAM(7) showed an excellent brain uptake in rats (1.41% dose at 2 min post intravenous [IV] injection), and consistently displayed the highest uptake (between 60-240 min post IV injection) in hypothalamus, a region with the highest density of SERT. The specific uptake of [{sup 125}I]ADAM(7) in the hypothalamus exhibited the highest target-to-nontarget ratio ([hypothalamus - cerebellum]/cerebellum was 3.97 at 120 min post IV injection). The preliminary imaging study of [{sup 123}I]ADAM in the brain of a baboon by single photon emission computed tomography (SPECT) at 180-240 min post IV injection indicated a specific uptake in midbrain region rich in SERT. These data suggest that the new ligand [{sup 123}I]ADAM(7) may be useful for SPECT imaging of SERT binding sites in the human brain.

Dr Adam Zamenhof (1888-1940) and his insight into ophthalmology.

Science.gov (United States)

Wincewicz, Andrzej; Sulkowska, Mariola; Lieberman, E James; Bakunowicz-Lazarczyk, Alina; Sulkowski, Stanislaw

2009-02-01

Adam Zamenhof was greatly influenced by his father, Ludwik Zamenhof, who designed the international language Esperanto. Like his father, he became an ophthalmologist and joined the Esperanto movement. He published in the field of ophthalmology and was soon chosen as head of an ophthalmology department. He subsequently became Chief of the Orthodox Jewish Hospital at Czystem in Warsaw. He was active in the leadership of the Bialystok-Warsaw Chamber of Medical Doctors. He perished in the Nazi Holocaust (Shoah) but all Zamenhof's ideals that Adam served as a doctor and social activist remain still alive.

J. B. Adams Acting Director-General

CERN Multimedia

1960-01-01

After the tragic death of Prof. C. J. Bakker, the Council of CERN held an emergency meeting on May 3, 1960. Following this session, Mr. F. de Rose, President of the Council of the European Organization for Nuclear Research, announced the appointment of Mr. J. B. Adams, Director of the PS division to the post of acting Director-General.

The Impact of Colorectal Cancer (CRC) in Mississippi, and the need for Mississippi to Eliminate its CRC Burden.

Science.gov (United States)

Duhé, Roy J

2016-03-01

Colorectal cancer (CRC), while highly preventable and highly treatable, is a major public health problem in Mississippi. This article reviews solutions to this problem, beginning with the relationship between modifiable behavioral risk factors and CRC incidence. It then describes the impact of CRC screening on national downward trends in CRC incidence and mortality and summarizes recent data on the burden of CRC in Mississippi. While other states have created Comprehensive Colorectal Cancer Control Programs in an organized effort to manage this public health problem, Mississippi has not. Responding to Mississippi's situation, the 70x2020 Colorectal Cancer Screening Initiative arose as an unconventional approach to increase CRC screening rates throughout the state. This article concludes by considering the current limits of CRC treatment success and proposes that improved clinical outcomes should result from research to translate recently-identified colorectal cancer subtype information into novel clinical paradigms for the treatment of early-stage colorectal cancer.

An activated form of ADAM10 is tumor selective and regulates cancer stem-like cells and tumor growth

Science.gov (United States)

Saha, Nayanendu; Eissman, Moritz F.; Xu, Kai; Llerena, Carmen; Kusebauch, Ulrike; Ding, Bi-Sen; Cao, Zhongwei; Rafii, Shahin; Ernst, Matthias; Scott, Andrew M.; Nikolov, Dimitar B.; Lackmann, Martin

2016-01-01

The transmembrane metalloprotease ADAM10 sheds a range of cell surface proteins, including ligands and receptors of the Notch, Eph, and erbB families, thereby activating signaling pathways critical for tumor initiation and maintenance. ADAM10 is thus a promising therapeutic target. Although widely expressed, its activity is normally tightly regulated. We now report prevalence of an active form of ADAM10 in tumors compared with normal tissues, in mouse models and humans, identified by our conformation-specific antibody mAb 8C7. Structure/function experiments indicate mAb 8C7 binds an active conformation dependent on disulfide isomerization and oxidative conditions, common in tumors. Moreover, this active ADAM10 form marks cancer stem-like cells with active Notch signaling, known to mediate chemoresistance. Importantly, specific targeting of active ADAM10 with 8C7 inhibits Notch activity and tumor growth in mouse models, particularly regrowth after chemotherapy. Our results indicate targeted inhibition of active ADAM10 as a potential therapy for ADAM10-dependent tumor development and drug resistance. PMID:27503072

Glyphosate-Resistant Goosegrass from Mississippi

Directory of Open Access Journals (Sweden)

Vijay K. Nandula

2013-05-01

Full Text Available A suspected glyphosate-resistant goosegrass [Eleusine indica (L. Gaertn.] population, found in Washington County, Mississippi, was studied to determine the level of resistance and whether the resistance was due to a point mutation, as was previously identified in a Malaysian population. Whole plant dose response assays indicated a two- to four-fold increase in resistance to glyphosate. Leaf disc bioassays based on a glyphosate-dependent increase in shikimate levels indicated a five- to eight-fold increase in resistance. Sequence comparisons of messenger RNA for epsps, the gene encoding the enzyme 5-enolpyruvylshikimate-3-phosphate synthase, from resistant and sensitive goosegrass, revealed a cytosine to thymine nucleotide change at position 319 in the resistant accessions. This single nucleotide polymorphism causes a proline to serine amino acid substitution at position 106 in 5-enolpyruvylshikimate-3-phosphate synthase. A real-time polymerase chain reaction assay using DNA probes specific for the nucleotide change at position 319 was developed to detect this polymorphism. Goosegrass from 42 locations were screened, and the results indicated that glyphosate-resistant goosegrass remained localized to where it was discovered. Pendimethalin, s-metolachlor, clethodim, paraquat and fluazifop controlled resistant goosegrass 93% to 100%, indicating that several control options for glyphosate-resistant goosegrass are available.

PENETAPAN ‘ADAM WALI NIKAH OLEH PEJABAT KUA DI KOTA SEMARANG

Directory of Open Access Journals (Sweden)

Rokhmadi

2016-10-01

Full Text Available This article is result of the study that describes the determination concept of adam wali nikah by officials of the Religious Affairs Office (KUA in Semarang, on marriage guardian of an ineligible woman, that because of the bride’s birth is less than six months from her parents’ marriage. Having determined adam marriage guardians’ status, then KUA establishes that the marriage guardian is delegated to KUA officials in each region of Semarang. As for the basis used by those who determine the delegation for the reason of deficient condition of marriage guardians for a female to the KUA is the use of the legal basis contained in adam marriage guardians’ determination in the letter of Director General Guidance and Pilgrimage Affairs Number: D/ED/PW.01/03/1992, in which its position is under the Marriage Legislation No. 1 of 1974 and the Islamic Law Compilation (KHI.

Preclinical pharmacological study on I-ADAM as a serotonin transporter ligand

International Nuclear Information System (INIS)

Wu Chunying; Lu Chunxiong; Jiang Quanfu; Zou Meifen; Chen Zhengping; Wang Songpei; Li Xiaomin; Zhang Tongxing; Zhu Junqing; Lin Xiangtong

2004-01-01

Objective: To evaluate the new ligand: I-2-( (22( (dimethylamino) methyl) phenyl) thio)-5- iodophenylamine (ADAM) as a serotonin imaging agent. Methods: Biological evaluations were performed in rats and mice. Results: Biodistribution studies in rats showed that the initial uptake of 131 I-ADAM in the brain was high (1.087%ID/organ at 2 min postinjection), and consistently displayed the highest binding (between 60-240 min postinjection) in hypothalamus, a region with the highest density of serotonin transporter (SERT). The specific binding [(TPCB)-1] of 131 I-ADAM in hypothalamus was 2.94, 3.03 and 3.09 at 60, 120 and 240 min postinjection, respectively. The (TPCB)-1 was significantly blocked by pretreatment with Paroxetine, which is known as a serotonin site reuptake inhibitor, while another nonselective competing drug, Ketanserin, showed no blocking effect. The rat brain autoradiography and analysis showed that there was high 131 I-ADAM uptake in hypothalamus, the ratio of hypothalamus/cerebellum was significantly reduced from 7.94 ± 0.39 to 1.30 ± 0.56 by pretreatment with Paroxetine at 60 min postinjection. Blood clearance kinetics was studied in rats, and the initial half-life of 13.79 min and late half-life of 357.14 min were obtained. The kinetic equation was: C=3.6147·e -0.0725t + 1.0413 e -0.0028t . The thyroid uptake was 0.009 and 1.421% ID/organ at 2 min and 120 min postinjection, respectively, suggesting that in vivo deiodination maybe the major route of metabolism. Toxicity trial showed that the dose per kilogram administered to mice was 1000 times greater than that to human beings, assuming a body-weight of 50 kg. Conclusion: These data suggest that 131 I-ADAM may be useful for SPECT imaging of SERT binding sits in the brain. (authors)

Modeled inundation limits of potential lahars from Mount Adams in the White Salmon River Valley, Washington

Science.gov (United States)

Griswold, Julia P.; Pierson, Thomas C.; Bard, Joseph A.

2018-05-09

Lahars large enough to reach populated areas are a hazard at Mount Adams, a massive volcano in the southern Cascade Range of Washington State (fig. 1). It is considered to be still active and has the potential to erupt again. By definition, lahars are gravity-driven flows of water-saturated mixtures of mud and rock (plus or minus ice, wood, and other debris), which originate from volcanoes and have a variety of potential triggering mechanisms (Vallance, 2000; Vallance and Iverson, 2015). Flowing mixtures can range in fluid consistency from something like a milkshake to something more like wet concrete, and they behave like flash floods, in that they can appear suddenly in river channels with little warning and commonly have boulder- or log-choked flow fronts. Lahars are hazardous because they can flow rapidly in confined valleys (commonly 20–35 miles per hour [mph] or 9–16 meters per second [m/s]), can travel more than 100 miles (mi) (161 kilometers [km]) from a source volcano, and can move with incredible destructive force, carrying multi-ton boulders and logs that can act as battering rams (Pierson, 1998). The biggest threats from lahars to downstream communities are present during eruptive activity, and impacts to communities can be dire. For example, a very large eruption-triggered lahar in Colombia in 1985 surprised and killed more than 20,000 people in a large town located about 45 mi (72 km) downstream and out of sight of the volcano that produced it (Pierson and others, 1990).Mount Adams, one of the largest volcanoes in the Cascade Range, is a composite stratocone composed primarily of andesite lava flows. It has been the most continuously active volcano within the 480-mi2 Mount Adams volcanic field—a region covering parts of Klickitat, Skamania, Yakima, andLewis Counties and part of the Yakama Nation Reservation in Washington State (Hildreth and Fierstein,1995, 1997). About 500,000 years in age, Mount Adams reached its present size by about 15

Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate {alpha}-secretase activity.

Science.gov (United States)

Kim, Minji; Suh, Jaehong; Romano, Donna; Truong, Mimy H; Mullin, Kristina; Hooli, Basavaraj; Norton, David; Tesco, Giuseppina; Elliott, Kathy; Wagner, Steven L; Moir, Robert D; Becker, K David; Tanzi, Rudolph E

2009-10-15

ADAM10, a member of a disintegrin and metalloprotease family, is an alpha-secretase capable of anti-amyloidogenic proteolysis of the amyloid precursor protein. Here, we present evidence for genetic association of ADAM10 with Alzheimer's disease (AD) as well as two rare potentially disease-associated non-synonymous mutations, Q170H and R181G, in the ADAM10 prodomain. These mutations were found in 11 of 16 affected individuals (average onset age 69.5 years) from seven late-onset AD families. Each mutation was also found in one unaffected subject implying incomplete penetrance. Functionally, both mutations significantly attenuated alpha-secretase activity of ADAM10 (>70% decrease), and elevated Abeta levels (1.5-3.5-fold) in cell-based studies. In summary, we provide the first evidence of ADAM10 as a candidate AD susceptibility gene, and report two potentially pathogenic mutations with incomplete penetrance for late-onset familial AD.

Loss of ADAM9 expression impairs β1 integrin endocytosis, focal adhesion formation and cancer cell migration

DEFF Research Database (Denmark)

Mygind, Kasper J; Schwarz, Jeanette; Sahgal, Pranshu

2018-01-01

knockdown increases β1 integrin levels through mechanisms that are independent of its protease activity. In ADAM9-silenced cells, adhesion to collagen and fibronectin is reduced, suggesting an altered function of the accumulated integrins. Mechanistically, ADAM9 co-immunoprecipitates with β1 integrin......, and both internalization and subsequent degradation of β1 integrin are significantly decreased in ADAM9-silenced cells, with no effect on β1 integrin recycling. Accordingly, the formation of focal adhesions and actin stress fibres in ADAM9-silenced cells is altered, possibly explaining the reduction...

Gender Ideology in The Diary Of Adam And Eve by Mark Twain

Directory of Open Access Journals (Sweden)

Paramita Ayuningtyas

2011-04-01

Full Text Available This article aims to show that behind the new version of Genesis by Mark Twain in his novel The Diary of Adam and Eve, there are some patriarchal principles that appear in it. It can be seen from the characterizations of Adam and Eve. By using some concepts from feminism and also focusing on the context of the novel, the analysis shows that patriarchal stereotypes about gender are applied in constructing the characters of Adam and Eve. Not only the content, but the form of the diary is also analyzed with the same method, and the same result is found. Therefore, it can be concluded that in spite of his progressiveness, Mark Twain still held patriarchal values in re-interpreting the tale of human creation.   

Analysis of membrane proteome and secretome in cells over-expressing ADAM17 using quantitative proteomics

International Nuclear Information System (INIS)

Kawahara, R.; Simabuco, F.M.; Yokoo, S.; Paes Leme, A.F.; Sherman, N.

2012-01-01

Full text: A disintegrin and metalloproteinase (ADAM) protease is involved in proteolytic ectodomain shedding of several membrane-associated proteins and modulation of key cell signaling pathways in the tumor microenvironment. In this study, we examined the effect of over-expressing the full length human ADAM17 in membrane and secreted proteins. To this end, we constructed a stable Flp-In T-RExHEK293 cells expressing ADAM17 by tetracycline induction. These cells were grown in Dulbeccos modified Eagles medium containing light lysine, arginine or heavy, L-Arg-13C615N4 and L-Lys -13C615N2 (SILAC: stable isotope labeling with amino acid in cell culture) media and they were treated with an ADAM17 activator, phorbolester (PMA). Controls such as Flp-In T-RExHEK293 cell without PMA treatment and without ADAM17 cloned were cultivated in light medium. The ADAM17 overexpression was induced with tetracycline 500 ng/ml for 24 hours. Cells in a heavy condition were treated with PMA 50 ng/ml for 1 hour and vehicle DMSO was used as control in a light cell condition. The extracellular media were collected, concentrated and used to evaluate the secretome and a cell surface biotinylation-based approach was used to capture cell surface-associated proteins. The biotinylated proteins were eluted with dithiothreitol, alkylated with iodoacetamide and then digested with trypsin. The resulting peptides were subjected to LC-MS/MS analysis on an ETD enabled Orbitrap Velos instrument. The results showed different proteins up or down regulated in membrane and secretome analysis which might represent potential molecules involved in signaling or ADAM17 regulation events. (author)

Retorika in Adam Small se "Kanna hy kô hystoe" | van Zyl | Tydskrif ...

African Journals Online (AJOL)

Adam Small, Kanna and 'that moral moment' This essay revisits Adam Small's best known play Kanna hy kô hystoe (“Kanna he comes home”, 1965) in order to evaluate its relevance for contemporary readers and audiences. The text, considered one of the classics of Afrikaans literature, is analysed from a rhetorical point of ...

33 CFR 223.1 - Mississippi River Water Control Management Board.

Science.gov (United States)

2010-07-01

..., responsibilities and authority of the Mississippi River Water Control Management Board. (b) Applicability. This... control management within the Mississippi River Basin. (c) Objectives. The objectives of the Board are: (1...) Composition. The Mississippi River Water Control Management Board is a continuing board consisting of the...

A Conversation with Adam Heller

OpenAIRE

Heller, A; Cairns, EJ

2015-01-01

© 2015 by Annual Reviews. All rights reserved. Adam Heller, Ernest Cockrell Sr. Chair in Engineering Emeritus of the John J. McKetta Department of Chemical Engineering at The University of Texas at Austin, recalls his childhood in the Holocaust and his contributions to science and technology that earned him the US National Medal of Technology and Innovation in a conversation with Elton J. Cairns, Professor of Chemical and Biomolecular Engineering at the University of California, Berkeley. Dr....

XOPÓS = Chorós : the dance of Adam

DEFF Research Database (Denmark)

Isar, Nicoletta

is contained in the very title of the book: “the Dance of Adam.” This dance alone gives ontological meaning to the Byzantine subject, to the whole Byzantine ¿¿¿¿¿¿¿a. In this choral equation, Adam stands for the humanity all-embracing. The book reads ¿¿¿¿¿ from an interdisciplinary perspective, incorporating....... The originality of Isar’s Chorography stands in unveiling and enforcing an important paradigm (¿¿¿¿¿) in the Byzantine studies, which has deep roots in ancient practices. However, the Byzantine ¿¿¿¿¿ reflects a unique ontology, a new vision of the mode of being, creation and imagination in Byzantium. Its ontology...

Woody biomass availability for bioethanol conversion in Mississippi

International Nuclear Information System (INIS)

Perez-Verdin, Gustavo; Grebner, Donald L.; Sun, Changyou; Munn, Ian A.; Schultz, Emily B.; Matney, Thomas G.

2009-01-01

This study evaluated woody biomass from logging residues, small-diameter trees, mill residues, and urban waste as a feedstock for cellulosic ethanol conversion in Mississippi. The focus on Mississippi was to assess in-state regional variations and provide specific information of biomass estimates for those facilities interested in locating in Mississippi. Supply and cost of four woody biomass sources were derived from Forest Inventory Analysis (FIA) information, a recent forest inventory conducted by the Mississippi Institute for Forest Inventory, and primary production costs. According to our analysis, about 4.0 million dry tons of woody biomass are available for production of up to 1.2 billion liters of ethanol each year in Mississippi. The feedstock consists of 69% logging residues, 21% small-diameter trees, 7% urban waste, and 3% mill residues. Of the total, 3.1 million dry tons (930 million liters of ethanol) can be produced for $34 dry ton -1 or less. Woody biomass from small-diameter trees is more expensive than other sources of biomass. Transportation costs accounted for the majority of total production costs. A sensitivity analysis indicates that the largest impacts in production costs of ethanol come from stumpage price of woody biomass and technological efficiency. These results provide a valuable decision support tool for resource managers and industries in identifying parameters that affect resource magnitude, type, and location of woody biomass feedstocks in Mississippi. (author)

Potential late-onset Alzheimer's disease-associated mutations in the ADAM10 gene attenuate α-secretase activity

Science.gov (United States)

Kim, Minji; Suh, Jaehong; Romano, Donna; Truong, Mimy H.; Mullin, Kristina; Hooli, Basavaraj; Norton, David; Tesco, Giuseppina; Elliott, Kathy; Wagner, Steven L.; Moir, Robert D.; Becker, K. David; Tanzi, Rudolph E.

2009-01-01

ADAM10, a member of a disintegrin and metalloprotease family, is an α-secretase capable of anti-amyloidogenic proteolysis of the amyloid precursor protein. Here, we present evidence for genetic association of ADAM10 with Alzheimer's disease (AD) as well as two rare potentially disease-associated non-synonymous mutations, Q170H and R181G, in the ADAM10 prodomain. These mutations were found in 11 of 16 affected individuals (average onset age 69.5 years) from seven late-onset AD families. Each mutation was also found in one unaffected subject implying incomplete penetrance. Functionally, both mutations significantly attenuated α-secretase activity of ADAM10 (>70% decrease), and elevated Aβ levels (1.5–3.5-fold) in cell-based studies. In summary, we provide the first evidence of ADAM10 as a candidate AD susceptibility gene, and report two potentially pathogenic mutations with incomplete penetrance for late-onset familial AD. PMID:19608551

ADAM13 Induces Cranial Neural Crest by Cleaving Class B Ephrins and Regulating Wnt Signaling

Science.gov (United States)

Wei, Shuo; Xu, Guofeng; Bridges, Lance C.; Williams, Phoebe; White, Judith M.; DeSimone, Douglas W.

2010-01-01

SUMMARY The cranial neural crest (CNC) are multipotent embryonic cells that contribute to craniofacial structures and other cells and tissues of the vertebrate head. During embryogenesis, CNC is induced at the neural plate boundary through the interplay of several major signaling pathways. Here we report that the metalloproteinase activity of ADAM13 is required for early induction of CNC in Xenopus. In both cultured cells and X. tropicalis embryos, membrane-bound Ephrins (Efns) B1 and B2 were identified as substrates for ADAM13. ADAM13 upregulates canonical Wnt signaling and early expression of the transcription factor snail2, whereas EfnB1 inhibits the canonical Wnt pathway and snail2 expression. We propose that by cleaving class B Efns, ADAM13 promotes canonical Wnt signaling and early CNC induction. PMID:20708595

Effects of [123I]ADAM, a serotonin transporter radiopharmaceutical, on pregnant Sprague–Dawley rats

International Nuclear Information System (INIS)

Chang, K.W.; Lin, M.C.; Lee, S.Y.; Chen, H.Y.; Chen, C.C.; Fu, Y.K.

2012-01-01

Serotonin transport abnormalities are implicated in neuropsychiatric disorders. [ 123 I]ADAM ([ 123 I]-2-([2-({dimethylamino}methyl)phenyl]thio)-5-iodophenylamine) is a novel radiotracer that targets serotonin transporters. We assessed the toxicity of [ 123 I]ADAM (18.5 MBq) administered in early- and late-phases (8 and 14 day postfertilization, respectively) of pregnancy. The mortality, clinical status, and gross necropsy were measured in pregnant rats, and the fertility index was measured in rat offspring (weight, clinical observations). We found no dosing-related clinical signs. In conclusion, [ 123 I]ADAM was not toxic in an animal pregnancy model.

Smith, Adam (1723-90)

DEFF Research Database (Denmark)

Bouchet, Dominique

2015-01-01

Adam Smith is often said to have been the founder of the science of economics and the father of liberalism in the sphere of economics. In fact he was neither. He lived at a turning point in western economic and political history, one that was littered with disruptive developments. He came up...... with a masterful synthesis of the economic knowledge of his period and emphasized both the relative autonomy of these phenomena and their importance in terms of generating wealth from, and in the interests of, everyone. Nevertheless, Smith never denied the moral foundation of economic behavior....

Reconnaissance level study Mississippi storm surge barrier

NARCIS (Netherlands)

Van Ledden, M.; Lansen, A.J.; De Ridder, H.A.J.; Edge, B.

2012-01-01

This paper reports a reconnaissance level study of a storm surge barrier in the Mississippi River. Historical hurricanes have shown storm surge of several meters along the Mississippi River levees up to and upstream of New Orleans. Future changes due to sea level rise and subsidence will further

Adam Smith, Religion, and Tuition Tax Credits.

Science.gov (United States)

Alexander, Kern

1983-01-01

Examines tuition tax credit programs in framework of Adam Smith's ideas on the economic impact of established churches. Finds that tuition tax credits would amount to state expenditures to relieve the financial burden of parochial school parents and would allow churches to invest commercially to maintain their charitable functions. (JW)

Adam Smith : Systematic Philosopher and Public Thinker

NARCIS (Netherlands)

Schliesser, E.

2017-01-01

This book treats Adam Smith as a systematic philosopher. Smith was a giant of the Scottish Enlightenment with polymath interests. The book explores Smith’s economics and ethics in light of his other commitments on the nature of knowledge, the theory of emotions, the theory of mind, his account of

Overexpression of the A Disintegrin and Metalloproteinase ADAM15 is linked to a Small but Highly Aggressive Subset of Prostate Cancers

Directory of Open Access Journals (Sweden)

Christoph Burdelski

2017-04-01

Full Text Available The A Disintegrin and Metalloproteinase (ADAM family of endopeptidases plays a role in many solid cancers and includes promising targets for anticancer therapies. Deregulation of ADAM15 has been linked to tumor aggressiveness and cell line studies suggest that ADAM15 overexpression may also be implicated in prostate cancer. To evaluate the impact of ADAM15 expression and its relationship with key genomic alterations, a tissue microarray containing 12,427 prostate cancers was analyzed by immunohistochemistry. ADAM15 expression was compared to phenotype, prognosis and molecular features including TMPRSS2:ERG fusion and frequent deletions involving PTEN, 3p, 5q and 6q. Normal prostate epithelium did not show ADAM15 staining. In prostate cancers, negative, weak, moderate, and strong ADAM15 staining was found in 87.7%, 3.7%, 5.6%, and 3.0% of 9826 interpretable tumors. Strong ADAM15 staining was linked to high Gleason grade, advanced pathological tumor stage, positive nodal stage and resection margin. ADAM15 overexpression was also associated with TMPRSS2:ERG fusions and PTEN deletions (P < .0001 but unrelated to deletions of 3p, 5q and 6q. In univariate analysis, high ADAM15 expression was strongly linked to PSA recurrence (P < .0001. However, in multivariate analyses this association was only maintained if the analysis was limited to preoperatively available parameters in ERG-negative cancers. The results of our study demonstrate that ADAM15 is strongly up regulated in a small but highly aggressive fraction of prostate cancers. In these tumors, ADAM15 may represent a suitable drug target. In a preoperative scenario, ADAM15 expression measurement may assist prognosis assessment, either alone or in combination with other markers.

Over-expression of two different forms of the alpha-secretase ADAM10 affects learning and memory in mice.

Science.gov (United States)

Schmitt, Ulrich; Hiemke, Christoph; Fahrenholz, Falk; Schroeder, Anja

2006-12-15

Members of the ADAM family (adisintegrin and metalloprotease) are the main candidates for physiologically relevant alpha-secretases. The alpha-secretase cleaves in the non-amyloidogenic pathway the amyloid precursor protein within the region of the Abeta peptides preventing their aggregation in the brain. The increase of alpha-secretase activity in the brain provides a plausible strategy to prevent Abeta formation. Concerning this possibility two transgenic mouse lines (FVB/N) have been created: mice over-expressing the bovine form of the alpha-secretase (ADAM10) and mice over-expressing an inactive form of the alpha-secretase (ADAM10-E348A-HA; ADAM10-dn). For behavioral examination a F1 generation of transgenic mice (C57Bl/6 x FVB/N (tg)) was generated and compared to wild type F1 generation (C57Bl/6 x FVB/N). Behavior was characterized in the following tasks: standard open field, enriched open field, elevated plus-maze, and the Morris water maze hidden platform task. Concerning basal activity, exploration, and anxiety, transgenic mice behaved similar to controls. With respect to learning and memory both transgenic lines showed a significant deficit compared to controls. ADAM10 mice however, showed thigmotaxis with passive floating behavior in the Morris water maze indicating differences in motivation, whereas, ADAM10-dn mice displayed an inconspicuous but limited goal-directed search pattern. Thus variation of the enzymatic activity of alpha-secretase ADAM10 alters learning and memory differentially. Nevertheless, it could be concluded that both, ADAM10 and ADAM10-dn mice are suitable control mice for the assessment of alpha-secretase-related effects in animal models of Alzheimer's disease.

76 FR 41555 - Tupelo, Mississippi Railroad Relocation Project

Science.gov (United States)

2011-07-14

... Relocation Project AGENCY: Federal Railroad Administration (FRA), U.S. Department of Transportation (DOT... Tupelo, Mississippi Railroad Relocation Project (Project). SUMMARY: The Federal Railroad Administration announces the availability of the Tupelo, Mississippi Railroad Relocation Project Draft Environmental Impact...

Paradise Lost: Difference between Adam and Eve’s Lament on Leaving Paradise - A Contrastive Analysis

Directory of Open Access Journals (Sweden)

Sara Torres Servín

2013-01-01

Full Text Available The difference between Adam and Eve’s lament on leaving Paradise in Milton’s Paradise Lost is striking in its contrastive content and depth. This paper analyzes the difference that exists between the feelings and spiritual attitudes that Adam and Eve express on the occasion when they are informed by the angel Michael that they have to abandon the Garden of Eden. It is a comparison of their lament in order to understand the contrast of the two attitudes that Milton wove in the tapestry that Paradise Lost is. The paper also explores male and female roles in Paradise Lost and concludes that Adam and Eve are equal yet different, that difference being the cause of their contrastive ways of expressing their sorrow. Adam and Eve manifest two contrastive worldviews in opposition, one spiritual (heavenly, and the other material (earthly.

Adam Smith and the Rhetoric of Style.

Science.gov (United States)

Moran, Michael G.

Historians of rhetoric have generally accepted the view that Adam Smith rejected the principles of classical rhetoric. However, while there can be no doubt that Smith greatly truncated the five classical arts of rhetoric (invention, arrangement, style, memory, and delivery) by reducing his concerns largely to style and arrangement, he did not…

Choctaws and Missionaries in Mississippi, 1818-1918.

Science.gov (United States)

Kidwell, Clara Sue

This book relates the history of the Choctaw Nation before and after the Indian Removal Act of 1830, which forced some Mississippi Choctaw to flee to Oklahoma. Some Choctaws nonetheless chose to remain in Mississippi, and today the tribe occupies eight reservation communities scattered throughout that state. The book constitutes a case study of…

Mississippi Department of Transportation research peer exchange : 2015.

Science.gov (United States)

2015-11-19

From October 20th to 22nd, 2015, the Mississippi Department of Transportation, with the assistance of The University of Southern Mississippi, hosted a peer exchange focusing on best practices. The goal of the peer exchange was to develop actionable r...

Association of ADAM33 gene polymorphisms with adult-onset ...

Indian Academy of Sciences (India)

2011-08-19

nucleotide ... Introduction. Asthma is a complex disease thought to arise from inter- ... The ADAM33 protein har- .... morphisms in patients and healthy controls are provided in ..... Nonetheless, meta-analyses encompassing data from.

ADAM12/syndecan-4 signaling promotes beta 1 integrin-dependent cell spreading through protein kinase Calpha and RhoA

DEFF Research Database (Denmark)

Thodeti, Charles Kumar; Albrechtsen, Reidar; Grauslund, Morten

2002-01-01

The ADAMs (a disintegrin and metalloprotease) comprise a large family of multidomain proteins with cell-binding and metalloprotease activities. The ADAM12 cysteine-rich domain (rADAM12-cys) supports cell attachment using syndecan-4 as a primary cell surface receptor that subsequently triggers beta...

Identification and Function of a Novel Candidate Gene for Asthma:ADAM 33

Directory of Open Access Journals (Sweden)

John W. Holloway

2005-01-01

Full Text Available Asthma is a complex disorder of inflammation and remodelling largely restricted to the conducting airways. It is a disorder where there are major genetics and environmental factors that interact together to initiate and propagate the disease into a chronic relapsing disorder. Until recently the genetic factors involved in disease pathogenesis have been restricted to variants in known molecules involved in the inflammatory or remodelling pathways. In this review evidence is presented for a new susceptibility gene for asthma, ADAM 33, that was identified by positional cloning. It is suggested that ADAM 33 plays a key role in predisposing to reduced lung function and bronchial hyperresponsiveness characteristic of asthma. Through an understanding of the disease-related SNPs(in ADAM 33it may be possible, not only to identify a gene based diagnostic test, but also to focus attention on developing a new treatment that reverses remodelling changes.

50 Years of synchrotrons Adams' Memorial lecture

CERN Document Server

Lawson, J D; CERN. Geneva

1996-01-01

Fifty years ago Frank Goward of the Atomic Energy Research Establishment Group at Malvern converted a small American betatron to make the worldÕs first synchrotron. At the same time Marcus Oliphant was planning to build at Birmingham a large proton machine with a ring magnet and variable magnetic field. Ideas for this had come to him during night-shifts tending the electromagnetic separators at Oak Ridge during the war. Some seven years later, in 1953, a group gathered together in Geneva to build the PS. A major contributor to the design work which had made this possible was John Adams. An account of some of the achievements in these eventful years will be presented. CERN has built nine synchrotrons/colliders and two temporary test rings. Eight machines are still running. The review will start with the PS, the first proton synchrotron based on the alternating gradient principle invented in 1952 at BNL. The design work of the PS team, under the enlightened leadership of J.B. Adams, and the construction of the...

Bottomland oak afforestation in the lower Mississippi

Science.gov (United States)

Emile S. Gardiner; Brian Roy Lockhard

2007-01-01

The 11 million hectare Lower Mississippi Alluvial Valley (LMAV), which is the geologic floodplain of the lower Mississippi River, is a prominent physiographic region in the southern United States. Seven states (Arkansas, Louisiana, Missis- 1 sippi, Missouri, Kentucky, Illinois, and Tennessee) border the lower stretch of the II River, and have a portion of their land...

EVA 1 - ADAM 1

International Nuclear Information System (INIS)

Decken, C.B. von der; Fedders, H.; Hoehlein, B.

1980-01-01

The supplying of industry and households with heat is a central problem in our economy. The crisis background of oil supply renders a long-term secured heat supply with nuclear power plants a discussible alternative. The district heating in the form of hot water, which is heated in power plants and supplied to the consumer via district heating pipeline networks, however, is limited due to the unavoidable heat losses. To bridge long distances between the heat source and consumer and to maintain the heat at a high temperature level, there are distinct advantages in using the EVA-ADAM principle of long-distance energy transport. (orig.) [de

Professor Adam Stalony-Dobrzański - the Master and the Teacher of Jerzy Nowosielski

Directory of Open Access Journals (Sweden)

Jarosław Szmajda

2014-11-01

Full Text Available When analyzing the history of Polish religious art of the XX century, we can affirm that the entire creative work of Adam Stalony-Dobrzański, professor at Kraków Academy of Fine Arts, remains in the shadow of the artistic output of Prof. Jerzy Nowosielski, his student and follower. Jerzy Nowosielski had a noticeable impact on the interest in the problems of the sacred in modern painting. The follower of Prof. Adam Stalony-Dobrzański was inspired by the art and the spirituality of Eastern Christianity. Prof. Jerzy Nowosielski filled some kind of a void in Polish religious art in the period of its evident crisis. Prof. Jerzy Nowosielski together with Prof. Adam Stalony-Dobrzański created polychrome frescoes of numerous religious buildings. The styling and the artistic accomplishments of Prof. Adam Stalony-Dobrzański are unknown for the wide audience which makes an evident gap in the history of Polish art. Polychrome frescoes and stainedglass windows can be seen in interiors of Catholic, Orthodox, and Protestant temples. The creative work of the Kraków artist is an example of the great and highly authentic vision of the sacred, which was stronger than communist censorship. The concept of Adam Stalony-Dobrzański’s art is not based on his theoretical conclusions but only on the analysis of correspondence of the artist with the then Metropolitan Archbishop of Kraków Karol Wojtyła - now St. Pope JohnPaul II. The topic of their letters was the issues of modern art and religious art, in particular the attempt to define a way in which art should be developed to meet the current needs of the Church. In contrast to the master, Prof. Adam Stalony-Dobrzański, his follower Prof. Jerzy Nowosielski has left ample commentary on his artwork. Prof. Adam Stalony-Dobrzański was rather a practitioner than a theoretician. Thus the fact of how great an impact he had on the character and the artwork of Jerzy Nowosielski is puzzling. In the first half of the

Landscape correlates along mourning dove call-count routes in Mississippi

Science.gov (United States)

Elmore, R.D.; Vilella, F.J.; Gerard, P.D.

2007-01-01

Mourning dove (Zenaida macroura) call-count surveys in Mississippi, USA, suggest declining populations. We used available mourning dove call-count data to evaluate long-term mourning dove habitat relationships. Dove routes were located in the Mississippi Alluvial Valley, Deep Loess Province, Mid Coastal Plain, and Hilly Coastal Plain physiographic provinces of Mississippi. We also included routes in the Blackbelt Prairie region of Mississippi and Alabama, USA. We characterized landscape structure and composition within 1.64-km buffers around 10 selected mourning dove call-count routes during 3 time periods. Habitat classes included agriculture, forest, urban, regeneration stands, wetland, and woodlot. We used Akaike's Information Criterion to select the best candidate model. We selected a model containing percent agriculture and edge density that contained approximately 40% of the total variability in the data set. Percent agriculture was positively correlated with relative dove abundance. Interestingly, we found a negative relationship between edge density and dove abundance. Researchers should conduct future research on dove nesting patterns in Mississippi and threshold levels of edge necessary to maximize dove density. During the last 20 years, Mississippi lost more than 800,000 ha of cropland while forest cover represented largely by pine (Pinus taeda) plantations increased by more than 364,000 ha. Our results suggest observed localized declines in mourning dove abundance in Mississippi may be related to the documented conversion of agricultural lands to pine plantations.

Sir John Adams - His Legacy to the World of Particle Accelerators

CERN Multimedia

CERN. Geneva

2009-01-01

John Adams acquired an unrivalled reputation for his leading part in designing and constructing the PS in CERN’s early days. In 1968, and after several years heading a fusion laboratory in the UK, he came back to Geneva to pilot the SPS project to approval and then to direct its construction. At the time of his untimely death in 1984 he had built Europe’s two largest proton accelerators at CERN. He went on, during the second of his terms as DG, to lay the groundwork for the proton-antiproton collider which led to the discovery of the intermediate vector boson. How did someone without any formal academic qualification achieve this? What was the magic behind his leadership? How did he achieve political success with the Member States of CERN in turning the almost hopeless quest for approval of the SPS to CERN’s advantage? How did he view his US counterpart, R. R. Wilson? The speaker, who worked many years alongside Adams, will discuss these questions and speculate on how Sir John Adams might have viewed t...

40 CFR 81.62 - Northeast Mississippi Intrastate Air Quality Control Region.

Science.gov (United States)

2010-07-01

... 40 Protection of Environment 17 2010-07-01 2010-07-01 false Northeast Mississippi Intrastate Air... Air Quality Control Regions § 81.62 Northeast Mississippi Intrastate Air Quality Control Region. The Alabama-Mississippi-Tennessee Interstate Air Quality Control Region has been renamed the Northeast...

Tuning a Le Mans Car Suspension in ADAMS

CSIR Research Space (South Africa)

Berman, R

2012-09-01

Full Text Available An ADAMS model of South Africa’s first ever Le Mans car was developed and used to tune the suspension parameters. Validation of the model is to be done by comparing simulation results to those obtained in track testing. The suspension parameters...

Comparison Virtual Landing Gear Drop Test for Commuter Aircraft Utilize MSC ADAMS And Solidworks Motion Analysis

Science.gov (United States)

Hidayat, Dony; Istiyanto, Jos; Agus Sumarsono, Danardono

2018-04-01

Loads at main landing gear while touchdown impact is function of aircraft weight and ground reaction load factor. In regulation states ground reaction load factor at Vsink = 3.05 m/s is below 3. Contact/impact force from simulation using MSC ADAMS is 94680 N, while using Solidworks Motion Analysis is 97691 N. The difference between MSC ADAMS and Solidworks Motion Analysis is 3.08%. The ground reaction load factor in MSC ADAMS is 2.78 while in Solidworks Motion Analysis is 2.87.

Program for the evaluation of TL-brick dating: 'ADAM-1-EVA'

International Nuclear Information System (INIS)

Novotna, V.; Kubelik, M.; Musilek, L.

2000-01-01

Although the evaluation of the TL-mean date has presented very little diversity since first published, the error evaluation has prompted a lot of discussion. Particularly the physical, chemical, statistical and mathematical differences as reflected in the specifics of the evaluation of the individual random and systematic errors in ceramic and brick dating are undervalued in literature. The construction of an automated TL-Reader (ADAM-1) at the Czech Technical University in Prague was taken as an opportunity to create a whole new software package for the evaluation ('EVA') of TL-dates. ADAM-1 is designed primarily for brick dating, using the fine-grain technique. The philosophy of data processing is similar to that applied by the Berlin group in their research of Venetian Villas. The program was developed using Delphi, as it is user-friendlier than pure Pascal, offers a strong graphic platform and allows flexibility in data management. This was important, as the program was conceived to either interact directly with ADAM-1, or to be operated independently for data evaluation and management. The software package consists of two discrete yet combinable components: one for the calculation of the TL mean date, using all raw data obtained from ADAM-1 and peripheral measurements; the other for the evaluation of systematic, random and context errors of individual samples and sample groups. All steps in the calculations are also graphically available, e.g. glow curves, plateau test, TL vs. dose dependence and charts summarising the results of all calculations for an individual sample and a given context. (author)

Siim Nestor soovitab : Ugly Duckling. Adam F / Siim Nestor

Index Scriptorium Estoniae

Nestor, Siim, 1974-

2006-01-01

Ameerika hip-hop-ansambli Ugly Duckling'i heliplaadi "Bang for the Buck"esitluskontserdist 9. nov. Tallinna klubis Hollywood. Inglise diskor Adam F drum'n'bass-üritusel "Sin City" 10. nov. Tartu linna klubis Tallinn

Mississippi CaP HBCU Undergraduate Research Training Program

Science.gov (United States)

2015-09-01

risk for African-Americans, obesity and medical distrust contribute to high rates of PCa in Mississippi. The scarcity of minority physicians and...Blue Fighting Prostate Cancer in the Mississippi Delta”. Anait S. Levenson, M.D., Ph.D., UMMC-CI, “Novel epigenetic mechanisms of dietary stilbenes

Concentrations and transport of suspended sediment, nutrients, and pesticides in the lower Mississippi-Atchafalaya River subbasin during the 2011 Mississippi River flood, April through July

Science.gov (United States)

Welch, Heather L.; Coupe, Richard H.; Aulenbach, Brent T.

2014-01-01

High streamflow associated with the April–July 2011 Mississippi River flood forced the simultaneous opening of the three major flood-control structures in the lower Mississippi-Atchafalaya River subbasin for the first time in history in order to manage the amount of water moving through the system. The U.S. Geological Survey (USGS) collected samples for analysis of field properties, suspended-sediment concentration, particle-size, total nitrogen, nitrate plus nitrite, total phosphorus, orthophosphate, and up to 136 pesticides at 11 water-quality stations and 2 flood-control structures in the lower Mississippi-Atchafalaya River subbasin from just above the confluence of the upper Mississippi and Ohio Rivers downstream from April through July 2011. Monthly fluxes of suspended sediment, suspended sand, total nitrogen, nitrate plus nitrite, total phosphorus, orthophosphate, atrazine, simazine, metolachlor, and acetochlor were estimated at 9 stations and 2 flood-control structures during the flood period. Although concentrations during the 2011 flood were within the range of what has been observed historically, concentrations decreased during peak streamflow on the lower Mississippi River. Prior to the 2011 flood, high concentrations of suspended sediment and nitrate were observed in March 2011 at stations downstream of the confluence of the upper Mississippi and Ohio Rivers, which probably resulted in a loss of available material for movement during the flood. In addition, the major contributor of streamflow to the lower Mississippi-Atchafalaya River subbasin during April and May was the Ohio River, whose water contained lower concentrations of suspended sediment, pesticides, and nutrients than water from the upper Mississippi River. Estimated fluxes for the 4-month flood period were still quite high and contributed approximately 50 percent of the estimated annual suspended sediment, nitrate, and total phosphorus fluxes in 2011; the largest fluxes were estimated at

ADAM13 function is required in the 3 dimensional context of the embryo during cranial neural crest cell migration in Xenopus laevis

Science.gov (United States)

Cousin, Hélène; Abbruzzese, Genevieve; McCusker, Catherine; Alfandari, Dominique

2012-01-01

The cranial neural crest (CNC) is a population of cells that arises from the lateral part of the developing brain, migrates ventrally and coordinates the entire craniofacial development of vertebrates. Many molecules are involved in CNC migration including the transmembrane metalloproteases ADAM13 and 19. We have previously shown that these ADAMs cleave a number of extracellular proteins and modify the transcription of a number of genes, and that both of these activities are important for cell migration. Here we show that the knock down of ADAM13 inhibits CNC migration in vivo but not in vitro, indicating that ADAM13 function is required in the 3-dimentional context of the embryo. We further show that the migration of CNC that do not express ADAM13 and ADAM19 can be rescued in vivo by co-grafting wild type CNC. Furthermore, the migration of CNC lacking ADAM13 can be rescued by mechanically separating the CNC from the surrounding ectoderm and mesoderm. Finally, we show that ADAM13 function is autonomous to CNC tissue, as the migration of morphant CNC can only be rescued by ADAM13 expression in the CNC and not the surrounding tissues. Together our results suggest that ADAM13 changes CNC interaction with the extracellular environment and that this change is necessary for their migration in vivo. PMID:22683825

IL-13-induced proliferation of airway epithelial cells: mediation by intracellular growth factor mobilization and ADAM17

Directory of Open Access Journals (Sweden)

Sandifer Tracy

2007-07-01

Full Text Available Abstract Background The pleiotrophic cytokine interleukin (IL-13 features prominently in allergic and inflammatory diseases. In allergic asthma, IL-13 is well established as an inducer of airway inflammation and tissue remodeling. We demonstrated previously that IL-13 induces release of transforming growth factor-α (TGFα from human bronchial epithelial cells, with proliferation of these cells mediated by the autocrine/paracrine action of this growth factor. TGFα exists as an integral membrane protein and requires proteolytic processing to its mature form, with a disintegrin and metalloproteinase (ADAM17 responsible for this processing in a variety of tissues. Methods In this study, normal human bronchial epithelial (NHBE cells grown in air/liquid interface (ALI culture were used to examine the mechanisms whereby IL-13 induces release of TGFα and cellular proliferation. Inhibitors and antisense RNA were used to examine the role of ADAM17 in these processes, while IL-13-induced changes in the intracellular expression of TGFα and ADAM17 were visualized by confocal microscopy. Results IL-13 was found to induce proliferation of NHBE cells, and release of TGFα, in an ADAM17-dependent manner; however, this IL-13-induced proliferation did not appear to result solely from ADAM17 activation. Rather, IL-13 induced a change in the location of TGFα expression from intracellular to apical regions of the NHBE cells. The apical region was also found to be a site of significant ADAM17 expression, even prior to IL-13 stimulation. Conclusion Results from this study indicate that ADAM17 mediates IL-13-induced proliferation and TGFα shedding in NHBE cells. Furthermore, they provide the first example wherein a cytokine (IL-13 induces a change in the intracellular expression pattern of a growth factor, apparently inducing redistribution of intracellular stores of TGFα to the apical region of NHBE cells where expression of ADAM17 is prominent. Thus, IL-13

ADAM28 is expressed by epithelial cells in human normal tissues and protects from C1q-induced cell death.

Science.gov (United States)

Miyamae, Yuka; Mochizuki, Satsuki; Shimoda, Masayuki; Ohara, Kentaro; Abe, Hitoshi; Yamashita, Shuji; Kazuno, Saiko; Ohtsuka, Takashi; Ochiai, Hiroki; Kitagawa, Yuko; Okada, Yasunori

2016-05-01

ADAM28 (disintegrin and metalloproteinase 28), which was originally reported to be lymphocyte-specific, is over-expressed by carcinoma cells and plays a key role in cell proliferation and progression in human lung and breast carcinomas. We studied ADAM28 expression in human normal tissues and examined its biological function. By using antibodies specific to ADAM28, ADAM28 was immunolocalized mainly to epithelial cells in several tissues, including epididymis, bronchus and stomach, whereas lymphocytes in lymph nodes and spleen were negligibly immunostained. RT-PCR, immunoblotting and ELISA analyses confirmed the expression in these tissues, and low or negligible expression by lymphocytes was found in the lymph node and spleen. C1q was identified as a candidate ADAM28-binding protein from a human lung cDNA library by yeast two-hybrid system, and specific binding was demonstrated by binding assays, immunoprecipitation and surface plasmon resonance. C1q treatment of normal bronchial epithelial BEAS-2B and NHBE cells, both of which showed low-level expression of ADAM28, caused apoptosis through activation of p38 and caspase-3, and cell death with autophagy through accumulation of LC3-II and autophagosomes, respectively. C1q-induced cell death was attenuated by treatment of the cells with antibodies against the C1q receptor gC1qR/p33 or cC1qR/calreticulin. Treatment of C1q with recombinant ADAM28 prior to addition to culture media reduced C1q-induced cell death, and knockdown of ADAM28 using siRNAs increased cell death. These data demonstrate that ADAM28 is expressed by epithelial cells of several normal organs, and suggest that ADAM28 plays a role in cell survival by suppression of C1q-induced cytotoxicity in bronchial epithelial cells. © 2016 Federation of European Biochemical Societies.

Ansel Adams's Eucalyptus Tree, Fort Ross: Nature, Photography, and the Search for California

OpenAIRE

Adam Arenson

2005-01-01

This article considers the image of California evoked in the unusual Ansel Adams photograph Eucalyptus Tree, Fort Ross, California (1969), a Polaroid Land image of the garrison fence and an aged eucalyptus tree. Considering the participation of Russian occupation, Australian cross-pollination, Carleton Watkins's early photographs of redwoods, automotive and tourist images in the creation of this distinctive California place, the article argues that to understand Ansel Adams's work, we must no...

The importance of ADAM family proteins in malignant tumors

Directory of Open Access Journals (Sweden)

Katarzyna Walkiewicz

2016-02-01

Full Text Available Increasing numbers of reports about the role of adamalysins (ADAM in malignant tumors are being published. To date, more than 30 representatives of this group, out of which about 20 occur in humans, have been described. The ADAM family is a homogeneous group of proteins which regulate, from the stage of embryogenesis, a series of processes such as cell migration, adhesion, and cell fusion. Half of them have proteolytic activity and are involved in the degradation of the extracellular matrix and the disintegration of certain protein complexes, thereby regulating the bioavailability of various growth factors. Many of these functions have a direct role in the processes of carcinogenesis and promoting the growth of tumor, which affect some signaling pathways, including those related to insulin-like growth factors (IGF1, IGF2, vascular growth factor (VEGF, tumor necrosis factor α (TNFα and the EGFR/HER pathway. Another branch of studies is the evaluation of the possibility of using members of ADAM family proteins in the diagnosis, especially in breast, colon and non- small cell lung cancer. The detection of concentrations of adamalysin in serum, urine and pleural aspirates might contribute to the development of methods of early diagnosis of cancer and monitoring the therapy. However, both the role of adamalysins in the development and progression of tumors and their importance as a diagnostic and predictive further research still need to be checked on large groups of patients.

[The importance of ADAM family proteins in malignant tumors].

Science.gov (United States)

Walkiewicz, Katarzyna; Gętek, Monika; Muc-Wierzgoń, Małgorzata; Kokot, Teresa; Nowakowska-Zajdel, Ewa

2016-02-11

Increasing numbers of reports about the role of adamalysins (ADAM) in malignant tumors are being published. To date, more than 30 representatives of this group, out of which about 20 occur in humans, have been described. The ADAM family is a homogeneous group of proteins which regulate, from the stage of embryogenesis, a series of processes such as cell migration, adhesion, and cell fusion. Half of them have proteolytic activity and are involved in the degradation of the extracellular matrix and the disintegration of certain protein complexes, thereby regulating the bioavailability of various growth factors. Many of these functions have a direct role in the processes of carcinogenesis and promoting the growth of tumor, which affect some signaling pathways, including those related to insulin-like growth factors (IGF1, IGF2), vascular growth factor (VEGF), tumor necrosis factor α (TNFα) and the EGFR/HER pathway. Another branch of studies is the evaluation of the possibility of using members of ADAM family proteins in the diagnosis, especially in breast, colon and non- small cell lung cancer. The detection of concentrations of adamalysin in serum, urine and pleural aspirates might contribute to the development of methods of early diagnosis of cancer and monitoring the therapy. However, both the role of adamalysins in the development and progression of tumors and their importance as a diagnostic and predictive further research still need to be checked on large groups of patients.

Mass spectrometry reveals thioredoxin-1 as a new partner of ADAM17 that can modulate its sheddase activity

International Nuclear Information System (INIS)

Aragao, A.Z.B.; Simabuco, F.M.; Smetana, J.H.C.; Yokoo, S.; Paes Leme, A.F.; Rodrigues, E.; Mercadante, A.Z.

2012-01-01

Full text: ADAMs are a family of membrane-associated metalloproteinases with a complex multi-domain structure: a metalloproteinase domain, a disintegrin domain, a cysteine-rich region, an epidermal growth factor-like repeat, a transmembrane domain and a cytoplasmic tail. These proteases are responsible for shedding the ectodomains of cell surface proteins, modulating regulatory mechanisms. Many ADAMs are highly associated with tumorigenesis and tumor progression. The aim of this study is identify novel binding partners that can modulate ADAM17 activation via cytoplasmatic domain. We performed the cloning and overexpression of the ADAM17 cytoplasmic tail in HEK-293 cell line and the ligands were determined by LC-MS/MS after proteins immunoprecipitation (IP) with anti-FLAG M2 Affinity Gel (Sigma). Thioredoxin-1 (Trx-1) and others ligands were identified at least in two independent experiments, and this binding is independent of phosphorylation. The IP of Trx-1 was confirmed by Western blot, furthermore Trx-1 immunolocalized with full length ADAM17-HA and cytoplasmic tail-FLAG recombinant proteins in HEK293 and HeLa cells. Trx-1 is part of the system peroxiredoxin/thioredoxin/thioredoxin reductase, one of the mechanisms by which cells maintain the reduced cellular environment, inactivating the reactive oxygen species (ROS). We investigate whether ADAM17 activity is modulate by Trx-1 on AP reporter assay that was performed using HEK293 and SCC-9 cells transfected stably with HB-EGF-AP in co-transfection with transient recombinant Trx-1-HA. The results indicate that Trx-1 can modulate negatively the activity or maturation of ADAM17 in presence of PMA, which is known to increase ROS. In summary, this study identifies Trx-1 and suggest that this protein can modulate ADAM17 activity in normal and tumorigenic cells lines. (author)

Mass spectrometry reveals thioredoxin-1 as a new partner of ADAM17 that can modulate its sheddase activity

Energy Technology Data Exchange (ETDEWEB)

Aragao, A.Z.B.; Simabuco, F.M.; Smetana, J.H.C. [Laboratorio Nacional de Biociencias - LNBIO, Campinas, SP (Brazil); Yokoo, S.; Paes Leme, A.F. [Laboratorio Nacional de Luz Sincrotron (LNLS), Campinas, SP (Brazil); Rodrigues, E.; Mercadante, A.Z. [Universidade Estadual de Campinas (UNICAMP), SP (Brazil)

2012-07-01

Full text: ADAMs are a family of membrane-associated metalloproteinases with a complex multi-domain structure: a metalloproteinase domain, a disintegrin domain, a cysteine-rich region, an epidermal growth factor-like repeat, a transmembrane domain and a cytoplasmic tail. These proteases are responsible for shedding the ectodomains of cell surface proteins, modulating regulatory mechanisms. Many ADAMs are highly associated with tumorigenesis and tumor progression. The aim of this study is identify novel binding partners that can modulate ADAM17 activation via cytoplasmatic domain. We performed the cloning and overexpression of the ADAM17 cytoplasmic tail in HEK-293 cell line and the ligands were determined by LC-MS/MS after proteins immunoprecipitation (IP) with anti-FLAG M2 Affinity Gel (Sigma). Thioredoxin-1 (Trx-1) and others ligands were identified at least in two independent experiments, and this binding is independent of phosphorylation. The IP of Trx-1 was confirmed by Western blot, furthermore Trx-1 immunolocalized with full length ADAM17-HA and cytoplasmic tail-FLAG recombinant proteins in HEK293 and HeLa cells. Trx-1 is part of the system peroxiredoxin/thioredoxin/thioredoxin reductase, one of the mechanisms by which cells maintain the reduced cellular environment, inactivating the reactive oxygen species (ROS). We investigate whether ADAM17 activity is modulate by Trx-1 on AP reporter assay that was performed using HEK293 and SCC-9 cells transfected stably with HB-EGF-AP in co-transfection with transient recombinant Trx-1-HA. The results indicate that Trx-1 can modulate negatively the activity or maturation of ADAM17 in presence of PMA, which is known to increase ROS. In summary, this study identifies Trx-1 and suggest that this protein can modulate ADAM17 activity in normal and tumorigenic cells lines. (author)

78 FR 20937 - Changes in Flood Hazard Determinations

Science.gov (United States)

2013-04-08

...-04-6774P). Kenneth E. Engineering www.bakeraecom.com/ Gulley, Mayor, Department, 1800 index.php..., index.php/colorado/ City, 7887 East Commerce City, CO adams/. 60th Avenue, 80022. Commerce City, CO.... Henry, Chair, Public Works www.bakeraecom.com/ County (13-08- Adams County Department, 4430 index.php...

Comparison of manual and automated quantification methods of 123I-ADAM

International Nuclear Information System (INIS)

Kauppinen, T.; Keski-Rahkonen, A.; Sihvola, E.; Helsinki Univ. Central Hospital

2005-01-01

123 I-ADAM is a novel radioligand for imaging of the brain serotonin transporters (SERTs). Traditionally, the analysis of brain receptor studies has been based on observer-dependent manual region of interest definitions and visual interpretation. Our aim was to create a template for automated image registrations and volume of interest (VOI) quantification and to show that an automated quantification method of 123 I-ADAM is more repeatable than the manual method. Patients, methods: A template and a predefined VOI map was created from 123 I-ADAM scans done for healthy volunteers (n=15). Scans of another group of healthy persons (HS, n=12) and patients with bulimia nervosa (BN, n=10) were automatically fitted to the template and specific binding ratios (SBRs) were calculated by using the VOI map. Manual VOI definitions were done for the HS and BN groups by both one and two observers. The repeatability of the automated method was evaluated by using the BN group. Results: For the manual method, the interobserver coefficient of repeatability was 0.61 for the HS group and 1.00 for the BN group. The intra-observer coefficient of repeatability for the BN group was 0.70. For the automated method, the coefficient of repeatability was 0.13 for SBRs in midbrain. Conclusion: An automated quantification gives valuable information in addition to visual interpretation decreasing also the total image handling time and giving clear advantages for research work. An automated method for analysing 123 I-ADAM binding to the brain SERT gives repeatable results for fitting the studies to the template and for calculating SBRs, and could therefore replace manual methods. (orig.)

Adam Smith and the Teaching of English Literature.

Science.gov (United States)

Court, Franklin E.

1985-01-01

Adam Smith used selections from English literature in his classroom during the eighteenth century because he believed that vernacular literature could provide a ready context for the teaching of ideological, social, and moral lessons. He believed that higher education should prepare students for the real business of the real world. (RM)

Mississippi National River and Recreation Area Water Trail Plan.

Science.gov (United States)

2017-05-05

The Water Trail Plan describes the current conditions of and future plans for the Mississippi National River and Recreation Area (NRRA), a 72-mile stretch of the Mississippi River running through the Twin Cities region of Minnesota. In 2012, the NRRA...

A new species of Casmaria H. Adams & A. Adams, 1853 (Gastropoda, Cassidae from the Philippines identified by molecular data

Directory of Open Access Journals (Sweden)

Alexander Fedosov

2014-03-01

Full Text Available The genus Casmaria H. Adams & A. Adams, 1853 (family Cassidae is widespread in the tropical Indo-Pacific and has been documented from some Atlantic localities as well. Two Casmaria species, C. erinaceus (Linnaeus, 1758 and C. ponderosa (Gmelin, 1791, are common in Indo-Pacific shallow-water sandy bottom communities and are characterized by high morphological variability; both species encompass multiple, often sympatric forms of uncertain status. In the present study we carry out a phylogenetic analysis of some Philippine Casmaria morphs and demonstrate that one of the distinctive morphs earlier assigned to Casmaria ponderosa is in fact a different species, which we describe as Casmaria boblehmani sp. nov. The smooth form of Casmaria ponderosa, C. ponderosa ponderosa, and the solid nodulose form, widely called “form nodulosa” despite being strikingly different in shell morphology, are shown to be conspecific. Studied specimens of these two morphs even from different localities share the same haplotype of the CO1 gene. In light of these new data on the morphological variability of Casmaria species, we discuss criteria of species delimitation in the genus Casmaria and possible affinities of Casmaria boblehmani sp. nov. within the genus.

HIV Clustering in Mississippi: Spatial Epidemiological Study to Inform Implementation Science in the Deep South.

Science.gov (United States)

Stopka, Thomas J; Brinkley-Rubinstein, Lauren; Johnson, Kendra; Chan, Philip A; Hutcheson, Marga; Crosby, Richard; Burke, Deirdre; Mena, Leandro; Nunn, Amy

2018-04-03

In recent years, more than half of new HIV infections in the United States occur among African Americans in the Southeastern United States. Spatial epidemiological analyses can inform public health responses in the Deep South by identifying HIV hotspots and community-level factors associated with clustering. The goal of this study was to identify and characterize HIV clusters in Mississippi through analysis of state-level HIV surveillance data. We used a combination of spatial epidemiology and statistical modeling to identify and characterize HIV hotspots in Mississippi census tracts (n=658) from 2008 to 2014. We conducted spatial analyses of all HIV infections, infections among men who have sex with men (MSM), and infections among African Americans. Multivariable logistic regression analyses identified community-level sociodemographic factors associated with HIV hotspots considering all cases. There were HIV hotspots for the entire population, MSM, and African American MSM identified in the Mississippi Delta region, Southern Mississippi, and in greater Jackson, including surrounding rural counties (PHIV cases, HIV hotspots were significantly more likely to include urban census tracts (adjusted odds ratio [AOR] 2.01, 95% CI 1.20-3.37) and census tracts that had a higher proportion of African Americans (AOR 3.85, 95% CI 2.23-6.65). The HIV hotspots were less likely to include census tracts with residents who had less than a high school education (AOR 0.95, 95% CI 0.92-0.98), census tracts with residents belonging to two or more racial/ethnic groups (AOR 0.46, 95% CI 0.30-0.70), and census tracts that had a higher percentage of the population living below the poverty level (AOR 0.51, 95% CI 0.28-0.92). We used spatial epidemiology and statistical modeling to identify and characterize HIV hotspots for the general population, MSM, and African Americans. HIV clusters concentrated in Jackson and the Mississippi Delta. African American race and urban location were

Adams National Historic Park Trolley Vehicle Replacement Selection Analysis

Science.gov (United States)

2017-12-01

Adams NHP owns three trolley vehicles that were purchased in the early 2000s and, while their accrued mileage remains low, they have reached the end of their useful lives due in large part to vehicle parts becoming unavailable. Both the original trol...

IL-5-stimulated eosinophils adherent to periostin undergo stereotypic morphological changes and ADAM8-dependent migration.

Science.gov (United States)

Johansson, M W; Khanna, M; Bortnov, V; Annis, D S; Nguyen, C L; Mosher, D F

2017-10-01

IL-5 causes suspended eosinophils to polarize with filamentous (F)-actin and granules at one pole and the nucleus in a specialized uropod, the "nucleopod," which is capped with P-selectin glycoprotein ligand-1 (PSGL-1). IL-5 enhances eosinophil adhesion and migration on periostin, an extracellular matrix protein upregulated in asthma by type 2 immunity mediators. Determine how the polarized morphology evolves to foster migration of IL-5-stimulated eosinophils on a surface coated with periostin. Blood eosinophils adhering to adsorbed periostin were imaged at different time points by fluorescent microscopy, and migration of eosinophils on periostin was assayed. After 10 minutes in the presence of IL-5, adherent eosinophils were polarized with PSGL-1 at the nucleopod tip and F-actin distributed diffusely at the opposite end. After 30-60 minutes, the nucleopod had dissipated such that PSGL-1 was localized in a crescent or ring away from the cell periphery, and F-actin was found in podosome-like structures. The periostin layer, detected with monoclonal antibody Stiny-1, shown here to recognize the FAS1 4 module, was cleared in wide areas around adherent eosinophils. Clearance was attenuated by metalloproteinase inhibitors or antibodies to disintegrin metalloproteinase 8 (ADAM8), a major eosinophil metalloproteinase previously implicated in asthma pathogenesis. ADAM8 was not found in podosome-like structures, which are associated with proteolytic activity in other cell types. Instead, immunoblotting demonstrated proteoforms of ADAM8 that lack the cytoplasmic tail in the supernatant. Anti-ADAM8 inhibited migration of IL-5-stimulated eosinophils on periostin. Migrating IL-5-activated eosinophils on periostin exhibit loss of nucleopodal features and appearance of prominent podosomes along with clearance of the Stiny-1 periostin epitope. Migration and epitope clearance are both attenuated by inhibitors of ADAM8. We propose, therefore, that eosinophils remodel and migrate

Electronic Cigarette Use among Mississippi Adults, 2015

OpenAIRE

Mendy, Vincent L.; Vargas, Rodolfo; Cannon-Smith, Gerri; Payton, Marinelle; Byambaa, Enkhmaa; Zhang, Lei

2017-01-01

Electronic cigarettes (e-cigarettes) are battery-powered devices that deliver nicotine in the form of aerosol. We identify differences and associations in e-cigarette use by sociodemographic characteristics and describe the reported reasons for initiating use among Mississippi adults. We used the 2015 Mississippi Behavioral Risk Factor Surveillance System, which collected information on e-cigarette use from 6,035 respondents. The prevalence of current e-cigarette use and having ever tried an ...

Historical Geography of the Upper Tombigbee Valley.

Science.gov (United States)

1982-05-01

Green . Routledge and Kegan Paul, London. Evans, W.A. 1939 Gaines Trace in Monroe County, Mississippi. Journal of Mis- sissippi History 1:100-109. 1940...Tombigbee Sand is a narrow belt extending from northwestern Tishomingo County into Pickens and Greene counties in Alabama (Carr, 1954). Except in...prominent in Greene County, Alabama, and can be traced northwestward into Mississippi (Parsons, 1950;Johnson, 1976). The Demopolis Chalk overlies the

Ectodomain Shedding by ADAM17: Its Role in Neutrophil Recruitment and the Impairment of This Process during Sepsis.

Science.gov (United States)

Mishra, Hemant K; Ma, Jing; Walcheck, Bruce

2017-01-01

Neutrophils are specialized at killing bacteria and are recruited from the blood in a rapid and robust manner during infection. A cascade of adhesion events direct their attachment to the vascular endothelium and migration into the underlying tissue. A disintegrin and metalloproteinase 17 (ADAM17) functions in the cell membrane of neutrophils and endothelial cells by cleaving its substrates, typically in a cis manner, at an extracellular site proximal to the cell membrane. This process is referred to as ectodomain shedding and it results in the downregulation of various adhesion molecules and receptors, and the release of immune regulating factors. ADAM17 sheddase activity is induced upon cell activation and rapidly modulates intravascular adhesion events in response to diverse environmental stimuli. During sepsis, an excessive systemic inflammatory response against infection, neutrophil migration becomes severely impaired. This involves ADAM17 as indicated by increased levels of its cleaved substrates in the blood of septic patients, and that ADAM17 inactivation improves neutrophil recruitment and bacterial clearance in animal models of sepsis. Excessive ADAM17 sheddase activity during sepsis thus appears to undermine in a direct and indirect manner the necessary balance between intravascular adhesion and de-adhesion events that regulate neutrophil migration into sites of infection. This review provides an overview of ADAM17 function and regulation and its potential contribution to neutrophil dysfunction during sepsis.

Compensation for dystrophin-deficiency: ADAM12 overexpression in skeletal muscle results in increased alpha 7 integrin, utrophin and associated glycoproteins

DEFF Research Database (Denmark)

Moghadaszadeh, Behzad; Albrechtsen, Reidar; Guo, Ling T

2003-01-01

Mouse models for genetic diseases are among the most powerful tools available for developing and testing new treatment strategies. ADAM12 is a disintegrin and metalloprotease, previously demonstrated to significantly alleviate the pathology of mdx mice, a model for Duchenne muscular dystrophy...... in humans. More specifically ADAM12 appeared to prevent muscle cell necrosis in the mdx mice as evidenced by morphological analysis and by the reduced levels of serum creatine kinase. In the present study we demonstrated that ADAM12 may compensate for the dystrophin deficiency in mdx mice by increasing...... the expression and redistribution of several components of the muscle cell-adhesion complexes. First, we analyzed transgenic mice that overexpress ADAM12 and found mild myopathic changes and accelerated regeneration following acute injury. We then analyzed changes in gene-expression profiles in mdx/ADAM12...

A comprehensive sediment budget for the Mississippi Barrier Islands

NARCIS (Netherlands)

Walstra, D.J.R.; De Vroeg, J.H.; Van Thiel de Vries, J.S.M.; Swinkels, C.; Luijendijk, A.P.; De Boer, W.P.; Hoekstra, R.; Hoonhout, B.; Henrotte, J.; Smolders, T.; Dekker, F.; Godsey, E.

2012-01-01

In order to conceive any realistic plan for post-Katrina island restoration, it is necessary to understand the physical processes that move sand along the littoral drift zone off the coast of Mississippi. This littoral zone influences the character of the Mississippi barrier islands as they exist in

John Adams Lecture

CERN Multimedia

PH Department

2010-01-01

13 December 2010 14:30 - Council Chamber, Bldg.503-1-001 Accelerator Breakthroughs, Achievements and Lessons from the Tevatron Collider V. Shiltsev / Fermilab’s Accelerator Physics Centre This year we celebrate the 25th anniversary of the first proton-antiproton collisions in the Tevatron. For two and a half decades the Tevatron at Fermilab (Batavia, IL, USA) was a centerpiece of the US and world’s High Energy Physics as the world’s highest energy particle collider at 1.8 TeV center of mass energy. While funding agencies are deciding on a 3-year extension of the Collider Run II operation through 2014, we – in this 2010 John Adams Lecture - will take a look in exciting story of the Tevatron: the story of long preparations, great expectations, numerous difficulties, years of “blood and sweat”, continuous upgrades, exceeding original goals (by a factor of 400) and high emotions. An accelerator scientist prospective will be given on a wide spectrum o...

Binding of ADAM12, a marker of skeletal muscle regeneration, to the muscle-specific actin-binding protein, alpha -actinin-2, is required for myoblast fusion

DEFF Research Database (Denmark)

Galliano, M F; Huet, C; Frygelius, J

2000-01-01

ADAM12 belongs to the transmembrane metalloprotease ADAM ("a disintegrin and metalloprotease") family. ADAM12 has been implicated in muscle cell differentiation and fusion, but its precise function remains unknown. Here, we show that ADAM12 is dramatically up-regulated in regenerated, newly formed...... of differentiation. Using the yeast two-hybrid screen, we found that the muscle-specific alpha-actinin-2 strongly binds to the cytoplasmic tail of ADAM12. In vitro binding assays with GST fusion proteins confirmed the specific interaction. The major binding site for alpha-actinin-2 was mapped to a short sequence...... in a dominant negative fashion by inhibiting fusion of C2C12 cells, whereas expression of a cytosolic ADAM12 lacking the major alpha-actinin-2 binding site had no effect on cell fusion. Our results suggest that interaction of ADAM12 with alpha-actinin-2 is important for ADAM12 function....

Lightweight robotic mobility: template-based modeling for dynamics and controls using ADAMS/car and MATLAB

Science.gov (United States)

Adamczyk, Peter G.; Gorsich, David J.; Hudas, Greg R.; Overholt, James

2003-09-01

The U.S. Army is seeking to develop autonomous off-road mobile robots to perform tasks in the field such as supply delivery and reconnaissance in dangerous territory. A key problem to be solved with these robots is off-road mobility, to ensure that the robots can accomplish their tasks without loss or damage. We have developed a computer model of one such concept robot, the small-scale "T-1" omnidirectional vehicle (ODV), to study the effects of different control strategies on the robot's mobility in off-road settings. We built the dynamic model in ADAMS/Car and the control system in Matlab/Simulink. This paper presents the template-based method used to construct the ADAMS model of the T-1 ODV. It discusses the strengths and weaknesses of ADAMS/Car software in such an application, and describes the benefits and challenges of the approach as a whole. The paper also addresses effective linking of ADAMS/Car and Matlab for complete control system development. Finally, this paper includes a section describing the extension of the T-1 templates to other similar ODV concepts for rapid development.

Linking the historic 2011 Mississippi River flood to coastal wetland sedimentation

Science.gov (United States)

Falcini, Federico; Khan, Nicole S.; Macelloni, Leonardo; Horton, Benjamin P.; Lutken, Carol B.; McKee, Karen L.; Santoleri, Rosalia; Colella, Simone; Li, Chunyan; Volpe, Gianluca; D’Emidio, Marco; Salusti, Alessandro; Jerolmack, Douglas J.

2012-01-01

Wetlands in the Mississippi River deltaic plain are deteriorating in part because levees and control structures starve them of sediment. In Spring of 2011 a record-breaking flood brought discharge on the lower Mississippi River to dangerous levels, forcing managers to divert up to 3500 m3/s-1 of water to the Atchafalaya River Basin. Here we quantify differences between the Mississippi and Atchafalaya River inundation and sediment-plume patterns using field-calibrated satellite data, and assess the impact these outflows had on wetland sedimentation. We characterize hydrodynamics and suspended sediment patterns of the Mississippi River plume using in-situ data collected during the historic flood. We show that the focused, high-momentum jet from the leveed Mississippi delivered sediment far offshore. In contrast, the plume from the Atchafalaya was more diffuse; diverted water inundated a large area; and sediment was trapped within the coastal current. Maximum sedimentation (up to several centimetres) occurred in the Atchafalaya Basin despite the larger sediment load carried by the Mississippi. Minimum accumulation occurred along the shoreline between these river sources. Our findings provide a mechanistic link between river-mouth dynamics and wetland sedimentation patterns that is relevant for plans to restore deltaic wetlands using artificial diversions.

ADAM15 is involved in MICB shedding and mediates the effects of gemcitabine on MICB shedding in PANC-1 pancreatic cancer cells.

Science.gov (United States)

Duan, Xiaohui; Mao, Xianhai; Sun, Weijia

2013-03-01

The aim of this study was to investigate the role of ADAM15 in MHC class I polypeptide-related sequence B (MICB) protein ectodomain shedding and observe whether or not gemcitabine affects MICB shedding from PANC-1 cells. In this study, immunohistochemistry of MICB and ADAM15 were performed on tumor samples obtained from 93 patients with pancreatic ductal adenocarcinoma (PDAC). The expression of MICB and ADAM15 in the PDAC tissues was significantly higher compared with that in the normal tissues of the pancreas. Statistical analysis showed a significant correlation between the expression of MICB and certain classic clinicopathological characteristics (i.e., histological grade and TNM stage). ADAM15 expression was found to correlate with lymph node metastasis and TNM stage. The Spearman's rank test suggested that the expression of MICB was inversely correlated with that of ADAM15 in PDAC tissues. Knockdown of ADAM15 in PANC-1 cells clearly upregulated MICB expression on the cellular surface and downregulated soluble MICB (sMICB) levels in the culture supernatants. A non-toxic dose of 0.5 µmol/l gemcitabine suppresses ADAM15 expression leading, at the same time, to an increase in MICB expression and a decrease in sMICB production in PANC-1 cells. The mRNA levels of MICB did not change following PANC-1 exposure to gemcitabine. Further study suggests that the suppressive effect of gemcitabine on MICB shedding in PANC-1 cells is mediated by ADAM15 downregulation. In conclusion, the results of the present study support the hypothesis that ADAM15 is involved in MICB shedding of PANC-1 cells and that gemcitabine inhibits MICB ectodomain shedding through the suppression of ADAM15.

The proposed Diagnostic Instrumentation and Analysis Laboratory, Mississippi State University

Energy Technology Data Exchange (ETDEWEB)

NONE

1994-11-01

The Department of Energy (DOE) proposes to authorize Mississippi State University (MSU) to proceed with the detailed design, construction and equipping of the proposed Diagnostic Instrumentation and Analysis Laboratory (DIAL). DOE grant funds are available to the University for the limited purpose of performing preliminary studies, including analysis necessary to conduct this environmental assessment. The proposed facility would be located in the Mississippi Research and Technology Park, adjacent to the Mississippi Agriculture and Forestry Experiment Station campus in Starkville, Mississippi. Total project cost is estimated at $7,953,600. This proposed laboratory would be designed to conduct research into combustion devices related to waste management and environmental restoration that is of importance to industry and government. The proposed facility`s role would be to develop diagnostic instrumentation capabilities in the area of combustion and related processes.

Adams-Oliver syndrome associated with cutis marmorata telangiectatica congenita and congenital cataract: a case report.

Science.gov (United States)

Fayol, Laurence; Garcia, Patricia; Denis, Danièle; Philip, Nicole; Simeoni, Umberto

2006-04-01

A female infant presented with Adams-Oliver syndrome (AOS), intrauterine growth retardation, severe cutis marmorata telangiectatica congenita, bilateral congenital cataract, and periventricular lesions. The here-reported association of bilateral congenital cataract with AOS is original. Adams-Oliver syndrome is a genetic defect that causes a vasculopathy and leads to a variety of phenotypes. This observation further supports the current understanding of the physiopathology of AOS.

Nonnative Fishes in the Upper Mississippi River System

Science.gov (United States)

Irons, Kevin S.; DeLain, Steven A.; Gittinger, Eric; Ickes, Brian S.; Kolar, Cindy S.; Ostendort, David; Ratcliff, Eric N.; Benson, Amy J.; Irons, Kevin S.

2009-01-01

The introduction, spread, and establishment of nonnative species is widely regarded as a leading threat to aquatic biodiversity and consequently is ranked among the most serious environmental problems facing the United States today. This report presents information on nonnative fish species observed by the Long Term Resource Monitoring Program on the Upper Mississippi River System a nexus of North American freshwater fish diversity for the Nation. The Long Term Resource Monitoring Program, as part of the U.S. Army Corps of Engineers' Environmental Management Plan, is the Nation's largest river monitoring program and stands as the primary source of standardized ecological information on the Upper Mississippi River System. The Long Term Resource Monitoring Program has been monitoring fish communities in six study areas on the Upper Mississippi River System since 1989. During this period, more than 3.5 million individual fish, consisting of 139 species, have been collected. Although fish monitoring activities of the Long Term Resource Monitoring Program focus principally on entire fish communities, data collected by the Program are useful for detecting and monitoring the establishment and spread of nonnative fish species within the Upper Mississippi River System Basin. Sixteen taxa of nonnative fishes, or hybrids thereof, have been observed by the Long Term Resource Monitoring Program since 1989, and several species are presently expanding their distribution and increasing in abundance. For example, in one of the six study areas monitored by the Long Term Resource Monitoring Program, the number of established nonnative species has increased from two to eight species in less than 10 years. Furthermore, contributions of those eight species can account for up to 60 percent of the total annual catch and greater than 80 percent of the observed biomass. These observations are critical because the Upper Mississippi River System stands as a nationally significant pathway for

An archaeology of Adam Smith's epistemic context

OpenAIRE

Vigo de Lima, I.; Guizzo, D.

2015-01-01

Adam Smith played a key role in Foucault's archaeology of political economy. This archaeology, which Foucault accomplished in The Order of Things, is the focus of this article. Foucault may have disagreed with the writings of the classical political economists but he widens our perspective through new possibilities of understanding. It is very illuminating to understand Smith's thinking as following a discursive practice that economic thought shared with the knowledge of living beings (natura...

Geologic mapping of near-surface sediments in the northern Mississippi Embayment, McCracken County, KY

Energy Technology Data Exchange (ETDEWEB)

Sexton, Joshua L [JL Sexton and Son; Fryar, Alan E [Dept of Earth and Geoligical Sciences, Univ of KY,; Greb, s F [Univ of KY, KY Geological Survey

2006-04-01

POSTER: The Jackson Purchase region of western Kentucky consists of Coastal Plain sediments near the northern margin of the Mississippi Embayment. Within this region is the Paducah Gaseous Diffusion Plant (PGDP), a uranium enrichment facility operated by the US Department of Energy. At PGDP, a Superfund site, soil and groundwater studies have provided subsurface lithologic data from hundreds of monitoring wells and borings. Despite preliminary efforts by various contractors, these data have not been utilized to develop detailed stratigraphic correlations of sedimentary units across the study area. In addition, sedimentary exposures along streams in the vicinityof PGDP have not been systematically described beyond the relatively simple geologic quadrangle maps published by the US Geological Survey in 1966-67. This study integrates lithologic logs, other previous site investigation data, and outcrop mapping to provide a compilation of near-surface lithologic and stratigraphic data for the PGDP area. A database of borehole data compiled during this study has been provided to PGDP for future research and archival.

Comparison of manual and automated quantification methods of {sup 123}I-ADAM

Energy Technology Data Exchange (ETDEWEB)

Kauppinen, T. [Helsinki Univ. Central Hospital (Finland). HUS Helsinki Medical Imaging Center; Helsinki Univ. Central Hospital (Finland). Division of Nuclear Medicine; Koskela, A.; Ahonen, A. [Helsinki Univ. Central Hospital (Finland). Division of Nuclear Medicine; Diemling, M. [Hermes Medical Solutions, Stockholm (Sweden); Keski-Rahkonen, A.; Sihvola, E. [Helsinki Univ. (Finland). Dept. of Public Health; Helsinki Univ. Central Hospital (Finland). Dept. of Psychiatry

2005-07-01

{sup 123}I-ADAM is a novel radioligand for imaging of the brain serotonin transporters (SERTs). Traditionally, the analysis of brain receptor studies has been based on observer-dependent manual region of interest definitions and visual interpretation. Our aim was to create a template for automated image registrations and volume of interest (VOI) quantification and to show that an automated quantification method of {sup 123}I-ADAM is more repeatable than the manual method. Patients, methods: A template and a predefined VOI map was created from {sup 123}I-ADAM scans done for healthy volunteers (n=15). Scans of another group of healthy persons (HS, n=12) and patients with bulimia nervosa (BN, n=10) were automatically fitted to the template and specific binding ratios (SBRs) were calculated by using the VOI map. Manual VOI definitions were done for the HS and BN groups by both one and two observers. The repeatability of the automated method was evaluated by using the BN group. Results: For the manual method, the interobserver coefficient of repeatability was 0.61 for the HS group and 1.00 for the BN group. The intra-observer coefficient of repeatability for the BN group was 0.70. For the automated method, the coefficient of repeatability was 0.13 for SBRs in midbrain. Conclusion: An automated quantification gives valuable information in addition to visual interpretation decreasing also the total image handling time and giving clear advantages for research work. An automated method for analysing {sup 123}I-ADAM binding to the brain SERT gives repeatable results for fitting the studies to the template and for calculating SBRs, and could therefore replace manual methods. (orig.)

ADAM10 mediates the house dust mite-induced release of chemokine ligand CCL20 by airway epithelium

NARCIS (Netherlands)

Post, S.; Rozeveld, D.; Jonker, M. R.; Bischoff, R.; van Oosterhout, A. J.; Heijink, I. H.

2015-01-01

Background: House dust mite (HDM) acts on the airway epithelium to induce airway inflammation in asthma. We previously showed that the ability of HDM to induce allergic sensitization in mice is related to airway epithelial CCL20 secretion. Objective: As a disintegrin and metalloprotease (ADAM)s have

Cardboard Boxes and Invisible Fences: Homelessness and Public Space in City of Victoria v. Adams

Directory of Open Access Journals (Sweden)

Sarah Buhler

2009-02-01

Full Text Available This paper analyzes the recent decision of the British Columbia Supreme Court in City of Victoria v. Adams. Specifically, the paper considers three interlocking themes that emerge from the decision: (1 the nature of “public space” in the context of homelessness; (2 the autonomy of homeless individuals; and (3 the meaning and value of the “homeless body.” With reference to each theme, the paper explores how the judgment in Adams grapples with the purportedly normative “Law and Economics”- type arguments put forth by the City of Victoria. By drawing on insights from Critical Legal Studies theory and feminist jurisprudence, the paper shows that Adams subverts and destabilizes certain “normative” perspectives about public space and homelessness. However, the paper goes on to argue that in its conflation of “cardboard box” shelters with the “invisible fences” envisioned by Justice Wilson in Morgentaler, Adams presents an ambiguous victory for anti-poverty advocates. The paper argues that the decision may serve to increase barriers for a broader and more progressive understanding of section 7 in the future. Dans cet article, on analyse le jugement récent de la Cour Suprême de la Colombie Britannique dans City of Victoria v. Adams. Plus précisément, on considère trois thèmes qui ressortent du jugement et qui s’entrecroisent : (1 la nature d’«espace public» dans le contexte de l’itinérance; (2 l’autonomie des sans-abri; et (3 la signification et la valeur du «corps sans abri». En rapport avec chaque thème, on explore comment l’arrêt Adams compose avec les arguments supposément normatifs du genre «La Loi et l’Économie» avancés par la ville de Victoria. En s’inspirant de perceptions tirées de la théorie des Critical Legal Studies et de la jurisprudence féministe, l’auteure démontre que l’arrêt Adams subvertit et déséquilibre certaines perspectives «normatives» au sujet de l�

Ectodomain shedding of Limbic System-Associated Membrane Protein (LSAMP) by ADAM Metallopeptidases promotes neurite outgrowth in DRG neurons.

Science.gov (United States)

Sanz, Ricardo L; Ferraro, Gino B; Girouard, Marie-Pier; Fournier, Alyson E

2017-08-11

IgLONs are members of the immunoglobulin superfamily of cell adhesion proteins implicated in the process of neuronal outgrowth, cell adhesion and subdomain target recognition. IgLONs form homophilic and heterophilic complexes on the cell surface that repress or promote growth depending on the neuronal population, the developmental stage and surface repertoire of IgLON family members. In the present study, we identified a metalloproteinase-dependent mechanism necessary to promote growth in embryonic dorsal root ganglion cells (DRGs). Treatment of embryonic DRG neurons with pan-metalloproteinase inhibitors, tissue inhibitor of metalloproteinase-3, or an inhibitor of ADAM Metallopeptidase Domain 10 (ADAM10) reduces outgrowth from DRG neurons indicating that metalloproteinase activity is important for outgrowth. The IgLON family members Neurotrimin (NTM) and Limbic System-Associated Membrane Protein (LSAMP) were identified as ADAM10 substrates that are shed from the cell surface of DRG neurons. Overexpression of LSAMP and NTM suppresses outgrowth from DRG neurons. Furthermore, LSAMP loss of function decreases the outgrowth sensitivity to an ADAM10 inhibitor. Together our findings support a role for ADAM-dependent shedding of cell surface LSAMP in promoting outgrowth from DRG neurons.

EFFICIENT MARKETING OF BLUEBERRIES IN MISSISSIPPI AND LOUISIANA

OpenAIRE

Muhammad, Safdar; Allen, Albert J.

2000-01-01

Fresh blueberries are sold through a marketing cooperative of the blueberry industry in Mississippi and Louisiana. Blueberry producers have numerous alternatives in assembling blueberries, and the cooperative needs to know the costs of different systems for assembling berries in order to provide better services to its members. The main objective of this study was to determine an efficient system for handling blueberries in Mississippi and Louisiana. Sixteen models with different combinations ...

Mississippi State Briefing Book for low-level radioactive waste management

Energy Technology Data Exchange (ETDEWEB)

None

1981-08-01

The Mississippi State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state an federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Mississippi. The profile is the result of a survey of NRC licensees in Mississippi. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Mississippi.

Mississippi State Briefing Book for low-level radioactive waste management

International Nuclear Information System (INIS)

1981-08-01

The Mississippi State Briefing Book is one of a series of state briefing books on low-level radioactive waste management practices. It has been prepared to assist state an federal agency officials in planning for safe low-level radioactive waste disposal. The report contains a profile of low-level radioactive waste generators in Mississippi. The profile is the result of a survey of NRC licensees in Mississippi. The briefing book also contains a comprehensive assessment of low-level radioactive waste management issues and concerns as defined by all major interested parties including industry, government, the media, and interest groups. The assessment was developed through personal communications with representatives of interested parties, and through a review of media sources. Lastly, the briefing book provides demographic and socioeconomic data and a discussion of relevant government agencies and activities, all of which may impact waste management practices in Mississippi

Levatiracetam for the management of Lance-Adams syndrome.

Science.gov (United States)

Ilik, Faik; Kemal Ilik, Mustafa; Cöven, Ilker

2014-01-01

Chronic post-hypoxic myoclonus, also known as Lance-Adams syndrome (LAS) is a neurological complication characterized by uncontrolled myoclonic jerks following cardiac arrest. In this article, clinical manifestation and symptomatic treatment options are discussed especially concerning the rationale of use of levatiracetam in patients with Lance-Adams syndrome. Clinical presentation is action myoclonus associated with cerebellar ataxia, postural imbalance, and very mild intellectual deficit. An 18-year-old female patient was admitted to our intensive care unit in a coma. She had a cardiorespiratory arrest after a splenectomy in a local hospital. Then, myoclonic movements were continuously observed over the entire body, including the face. On day 14 of hospitalization, we started levatiracetam 1000 mg daily. The frequency of convulsion movements was reduced. The patient level of consciousness was 15 on the Glasgow coma scale (GCS) on the Mini-Mental State Examination (MMSE) score was 23 out of 30. She was later transferred to the rehabilitation department. Vigilance is required to ensure early diagnosis and timely intervention for the myoclonic jerks. We would like to emphasize that LAS should be considered in patients with the myoclonic jerks following cardiac arrest and that levatiracetam therapy may be useful as treatment.

O mercado como ordem social em Adam Smith, Walras e Hayek The market as a social order in Adam Smith , Walras and Hayek

Directory of Open Access Journals (Sweden)

Angela Ganem

2012-04-01

Full Text Available O objetivo do artigo é apresentar criticamente as teorias do mercado de Adam Smith, Leon Walras e F. A. Hayek, sublinhando o que se considera terem em comum, ou seja, a ideia de mercado como expressão da ordem social capitalista. Entende-se que esta concepção do mercado como ordem social aparece originariamente na história do pensamento econômico e na história das ideias através da solução de Adam Smith frente aos filósofos do contrato e avança, analiticamente, um século após, na tentativa de demonstração lógico-matemática da Teoria do Equilíbrio Geral em Walras para adquirir a souplesse teórica necessária a sua sobrevivência, no século XX, na teoria de Hayek, em que a história realizaria o autodesenvolvimento da ordem do mercado. O texto percorre as filiações filosóficas e as implicações metodológicas das teorias do mercado desses grandes autores, mostrando as formas diferenciadas que elas assumem: ordem natural para Smith, ordem racional para Walras e ordem espontânea para Hayek.The objective of the article is to critically present the liberal theories of Adam Smith, Leon Walras and F. A. Hayek, underlining what they have in common, that is, the idea of market as a general theory of society and the construction of scientific attributes that make possible the understanding of the supremacy of market order against other forms of social organization. It is assumed that this conception of market as social order appears originally in the history of economical thought and in the history of ideas through Adam Smith's solution against contract philosophers and that it advances analytically, a century later, in the attempt of logic-mathematic demonstration in Walras, to acquire the necessary theoretical souplesse for its survival, in the XX century, in the Darwinian adventures of the Austrian school libertarians, specially Hayek, for whom history would realize the self-development of the market. The text will traverse the

Evaluating the ecological association of casino industry economic development on community health status: a natural experiment in the Mississippi delta region.

Science.gov (United States)

Honoré, Peggy A; Simoes, Eduardo J; Moonesinghe, Ramal; Wang, Xueyuan; Brown, Lovetta

2007-01-01

Objectives of this study were to examine for associations of casino industry economic development on improving community health status and funding for public health services in two counties in the Mississippi Delta Region of the United States. An ecological approach was used to evaluate whether two counties with casino gaming had improved health status and public health funding in comparison with two noncasino counties in the same region with similar social, racial, and ethic backgrounds. Variables readily available from state health department records were used to develop a logic model for guiding analytical work. A linear regression model was built using a stepwise approach and hierarchical regression principles with many dependent variables and a set of fixed and nonfixed independent variables. County-level data for 23 variables over an 11-year period were used. Overall, this study found a lack of association between the presence of a casino and desirable health outcomes or funding for public health services. Changes in the environment were made to promote health by utilizing gaming revenues to build state-of-the-art community health and wellness centers and sports facilities. However, significant increases in funding for local public health services were not found in either of the counties with casinos. These findings are relevant for policy makers when debating economic development strategies. Analysis similar to this should be combined with other routine public health assessments after implementation of development strategies to increase knowledge of health outcome trends and shifts in socioeconomic position that may be expected to accrue from economic development projects.

In vivo quantification by SPECT of [123I] ADAM bound to serotonin transporters in the brains of rabbits

International Nuclear Information System (INIS)

Ye, X.-X.; Hwang, J.-J.; Hsieh, J.-F.; Chen, J.-C.; Chou, Y.-T.; Tu, K.-Y.; Wey, S.-P.; Ting Gann

2004-01-01

Background: A novel radioiodine ligand [ 123 I] ADAM (2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine) has been suggested as a promising serotonin transporter (SERT) imaging agent for the central nervous system. In this study, the biodistribution of SERTs in the rabbit brain was investigated using [ 123 I] ADAM and mapping images of the same animal produced by both single-photon emission computed tomography (SPECT) and microautoradiography. A semiquantification method was adopted to deduce the optimum time for SPECT imaging, whereas the input for a simple fully quantitative tracer kinetic model was provided from arterial blood sampling data. Methods: SPECT imaging was performed on female rabbits postinjection of 185 MBq [ 123 I] ADAM. The time-activity curve obtained from the SPECT images was used to quantify the SERTs, for which the binding potential was calculated from the kinetic modeling of [ 123 I] ADAM. The kinetic data were analyzed by the nonlinear least squares method. The effects of the selective serotonin reuptake inhibitors fluoxetine and p-chloroamphetamine (PCA) on rabbits were also evaluated. After scanning, the same animal was sacrificed and the brain was removed for microautoradiography. Regions-of-interest were analyzed using both SPECT and microautoradiography images. The SPECT images were coregistered manually with the corresponding microautoradiography images for comparative study. Results: During the time interval 90-100 min postinjection, the peak specific binding levels in different brain regions were compared and the brain stem was shown to have the highest activity. The target-to-background ratio was 1.89±0.02. Similar studies with fluoxetine and PCA showed a background level for SERT occupation. Microautoradiography demonstrated a higher level of anatomical details of the [ 123 I] ADAM distribution than that obtained by SPECT imaging of the rabbit brain. Conclusion: SPECT imaging of the rabbit brain with [ 123 I] ADAM showed

Adam Olearius ja kultuuriline Teine teekonnal Oktsidendist Orienti / Aigi Heero, Maris Saagpakk

Index Scriptorium Estoniae

Heero, Aigi, 1971-

2013-01-01

Erinevate rahvaste kujutamisest 1656. aastal ilmunud Adam Oleariuse tuntud varauusaegses reisikirjas "Vermehrte Newe Beschreibung Der Muscowitischen vnd Persischen Reyse". Eestlaste kujutamisest võrdluses teiste rahvastega

Toward Understanding Trust: A Response to Adams and Miskell

Science.gov (United States)

Romero, Lisa S.; Mitchell, Douglas E.

2018-01-01

Purpose: Trust is a key component of successful schools. Although scholars widely agree that trust is multifaceted, there is less agreement about the number and nature of these factors. In the October 2016 issue of "Educational Administration Quarterly," C. M. Adams and Miskell (see EJ1112413) argued that their Teacher Trust of District…

Commentary to Adam Oliver's 'Incentivising improvements in health care delivery'

DEFF Research Database (Denmark)

Vrangbaek, Karsten

2015-01-01

The commentary discusses key issues for assessment of performance management within health care. It supports the ambition to develop more realistic understandings of performance management based on insights from behavioral economics as suggested by Adam Oliver. However, it also points to several ...

Fenotipo grave en dos medio hermanas con síndrome de Adams Oliver

OpenAIRE

Sevilla-Montoya, Rosalba; Ríos-Flores, Braulio; Moreno-Verduzco, Elsa; Domínguez-Castro, Mauricio; Rivera-Pedroza, Carlos I; Aguinaga-Ríos, Dra. Mónica

2014-01-01

El síndrome de Adams Oliver (AOS) es una entidad heterogénea con defecto transverso terminal de extremidades (TTLD) y aplasia cutis congénita (ACC) con un amplio espectro fenotípico. Se han descrito diferentes modos de herencia en esta enfermedad; los defectos más graves se han asociado a un patrón autosómico recesivo (AR). Objetivo. presentar a una familia con dos medio hermanas con un fenotipo grave de Adams Oliver, con una madre sana. Reporte del caso: una mujer de 27 años de edad fue refe...

Adam M. Reid: APA/APAGS Award for Distinguished Graduate Student in Professional Psychology.

Science.gov (United States)

2015-11-01

The APA/APAGS Award for Distinguished Graduate Student in Professional Psychology is awarded on an annual basis by the APA Board of Professional Affairs (BPA) and the American Psychological Association of Graduate Students (APAGS) to a graduate student who has demonstrated outstanding practice and application of psychology. One of the 2015 award winners is Adam M. Reid, who received this award "for his community service, in which he has integrated the highest standards of professional psychological clinical practice and science." Adam's award citation, biography, and a selected bibliography are presented here. (c) 2015 APA, all rights reserved).

Empathy's purity, sympathy's complexities; De Waal, Darwin and Adam Smith.

Science.gov (United States)

van der Weele, Cor

2011-07-01

Frans de Waal's view that empathy is at the basis of morality directly seems to build on Darwin, who considered sympathy as the crucial instinct. Yet when we look closer, their understanding of the central social instinct differs considerably. De Waal sees our deeply ingrained tendency to sympathize (or rather: empathize) with others as the good side of our morally dualistic nature. For Darwin, sympathizing was not the whole story of the "workings of sympathy"; the (selfish) need to receive sympathy played just as central a role in the complex roads from sympathy to morality. Darwin's understanding of sympathy stems from Adam Smith, who argued that the presence of morally impure motives should not be a reason for cynicism about morality. I suggest that De Waal's approach could benefit from a more thorough alignment with the analysis of the workings of sympathy in the work of Darwin and Adam Smith.

ADAM: analysis of discrete models of biological systems using computer algebra.

Science.gov (United States)

Hinkelmann, Franziska; Brandon, Madison; Guang, Bonny; McNeill, Rustin; Blekherman, Grigoriy; Veliz-Cuba, Alan; Laubenbacher, Reinhard

2011-07-20

Many biological systems are modeled qualitatively with discrete models, such as probabilistic Boolean networks, logical models, Petri nets, and agent-based models, to gain a better understanding of them. The computational complexity to analyze the complete dynamics of these models grows exponentially in the number of variables, which impedes working with complex models. There exist software tools to analyze discrete models, but they either lack the algorithmic functionality to analyze complex models deterministically or they are inaccessible to many users as they require understanding the underlying algorithm and implementation, do not have a graphical user interface, or are hard to install. Efficient analysis methods that are accessible to modelers and easy to use are needed. We propose a method for efficiently identifying attractors and introduce the web-based tool Analysis of Dynamic Algebraic Models (ADAM), which provides this and other analysis methods for discrete models. ADAM converts several discrete model types automatically into polynomial dynamical systems and analyzes their dynamics using tools from computer algebra. Specifically, we propose a method to identify attractors of a discrete model that is equivalent to solving a system of polynomial equations, a long-studied problem in computer algebra. Based on extensive experimentation with both discrete models arising in systems biology and randomly generated networks, we found that the algebraic algorithms presented in this manuscript are fast for systems with the structure maintained by most biological systems, namely sparseness and robustness. For a large set of published complex discrete models, ADAM identified the attractors in less than one second. Discrete modeling techniques are a useful tool for analyzing complex biological systems and there is a need in the biological community for accessible efficient analysis tools. ADAM provides analysis methods based on mathematical algorithms as a web

Paradise Lost: Difference Between Adam and Eve's Lament on Leaving Paradise - a Contrastive Analysis

OpenAIRE

Servín, Sara Torres

2013-01-01

The difference between Adam and Eve’s lament on leaving Paradise in Milton’s Paradise Lost is striking in its contrastive content and depth. This paper analyzes the difference that exists between the feelings and spiritual attitudes that Adam and Eve express on the occasion when they are informed by the angel Michael that they have to abandon the Garden of Eden. It is a comparison of their lament in order to understand the contrast of the two attitudes that Milton wove in the tapestry that Pa...

Pastoral care and healing in Africa: Towards an Adamic Christological practical theology imagination for pastoral healing

Directory of Open Access Journals (Sweden)

Vhumani Magezi

2016-11-01

Full Text Available This article argues that the challenge and need for relevant ministry models is critical for effective Christian ministry and pastoral ministry as practical life ministry. It establishes an Adamic Christological model as a paradigm that provides a practical effective ministerial approach in Africa, particularly within the context of pastoral care and healing. This framework reveals Christ’s complete identification with African Christians in their contextual sufferings as the New Adam without compromising authentic gospel reality. In employing the Adamic Christological framework as the anchor for African pastoral and healing ministry, a model for African Christians’ daily response to their various contextual sufferings is constructed. This responsive model bridges the gap between the ascension of Christ and the interim period of Christianity by instituting God’s ongoing personal presence in believers’ suffering through the Holy Spirit (pneumatology as an encouraging and comforting reality that should enable Christians to cope in their suffering. It is argued that this Adamic Christological framework provides a practical theological model that contributes to healing and hope in pastoral care through practical knowing that impacts and imparts meaning in life.

Poor interoperability of the Adams-Harbertson method for analysis of anthocyanins: comparison with AOAC pH differential method.

Science.gov (United States)

Brooks, Larry M; Kuhlman, Benjamin J; McKesson, Doug W; McCloskey, Leo

2013-01-01

The poor interoperability of anthocyanin glycosides measurements by two pH differential methods is documented. Adams-Harbertson, which was proposed for commercial winemaking, was compared to AOAC Official Method 2005.02 for wine. California bottled wines (Pinot Noir, Merlot, and Cabernet Sauvignon) were assayed in a collaborative study (n=105), which found mean precision of Adams-Harbertson winery versus reference measurements to be 77 +/- 20%. Maximum error is expected to be 48% for Pinot Noir, 42% for Merlot, and 34% for Cabernet Sauvignon from reproducibility RSD. Range of measurements was actually 30 to 91% for Pinot Noir. An interoperability study (n=30) found Adams-Harbertson produces measurements that are nominally 150% of the AOAC pH differential method. Large analytical chemistry differences are: AOAC method uses Beer-Lambert equation and measures absorbance at pH 1.0 and 4.5, proposed a priori by Flueki and Francis; whereas Adams-Harbertson uses "universal" standard curve and measures absorbance ad hoc at pH 1.8 and 4.9 to reduce the effects of so-called co-pigmentation. Errors relative to AOAC are produced by Adams-Harbertson standard curve over Beer-Lambert and pH 1.8 over pH 1.0. The study recommends using AOAC Official Method 2005.02 for analysis of wine anthocyanin glycosides.

The SPECT tracer [123I]ADAM binds selectively to serotonin transporters: a double-blind, placebo-controlled study in healthy young men

International Nuclear Information System (INIS)

Giessen, Elsmarieke van de; Booij, Jan

2010-01-01

The tracer 123 I-2-([2-({dimethylamino}methyl)phenyl]thio)-5-iodophenylamine ([ 123 I]ADAM) has been developed to image serotonin transporters (SERTs) with SPECT. Preclinical studies have shown that [ 123 I]ADAM binds selectively to SERTs. Moreover, initial human studies have shown that [ 123 I]ADAM binding could be blocked by selective serotonin reuptake inhibitors (SSRIs). However, in humans it has not been proven that [ 123 I]ADAM binds selectively to SERTs. We examined the in vivo availability of SERTs in 12 healthy young volunteers 5 h after bolus injection of [ 123 I]ADAM. To evaluate the selectivity of binding, four participants were pretreated (double-blinded design) with placebo, four with paroxetine (20 mg) and four with the dopamine/norepinephrine blocker methylphenidate (20 mg). SPECT studies were performed on a brain-dedicated system (Neurofocus), and the SPECT images were coregistered with individual MR scans of the brain. ADAM binding in SERT-rich brain areas and cerebellar cortex (representing non-specific binding) was assessed by drawing regions of interest (ROIs) on the individual MR images. Specific to non-specific ratios were used as the outcome measure. We found that specific to non-specific ratios were statistically significantly lower in paroxetine-pretreated participants than in placebo- or methylphenidate-pretreated participants. No such difference was found between groups pretreated with placebo or methylphenidate. Our preliminary findings suggest that [ 123 I]ADAM binds selectively to SERTs in human brain. (orig.)

Mississippi graduate DOE EPSCor trainee project. First annual summary report

Energy Technology Data Exchange (ETDEWEB)

Wertz, D.L.

1992-08-01

The promotion of an aggressive energy research initiative was identified as a goal of the Mississippi Research Consortium (MRC) from its inception in 1986. The Department of Energy EPSCOR Program has provided opportunities to address the needs and enhance the interactive programs of energy-related research in the State of Mississippi. The Mississippi DOE EPSCOR Graduate Traineeships Project is a program of education and research which will (1) increase the number of trained professionals in the energy sciences and technology, particularly those from groups traditionally under-represented in the field, and (2) interface with existing networks of universities, industry, federal, and state institutions involved in energy-related activities.

Mississippi graduate DOE EPSCor trainee project. [First Annual Summary Report

Energy Technology Data Exchange (ETDEWEB)

Wertz, D.L.

1992-08-01

The promotion of an aggressive energy research initiative was identified as a goal of the Mississippi Research Consortium (MRC) from its inception in 1986. The Department of Energy EPSCOR Program has provided opportunities to address the needs and enhance the interactive programs of energy-related research in the State of Mississippi. The Mississippi DOE EPSCOR Graduate Traineeships Project is a program of education and research which will (1) increase the number of trained professionals in the energy sciences and technology, particularly those from groups traditionally under-represented in the field, and (2) interface with existing networks of universities, industry, federal, and state institutions involved in energy-related activities.

Neuron-Derived ADAM10 Production Stimulates Peripheral Nerve Injury-Induced Neuropathic Pain by Cleavage of E-Cadherin in Satellite Glial Cells.

Science.gov (United States)

Li, Jian; Ouyang, Qing; Chen, Cheng-Wen; Chen, Qian-Bo; Li, Xiang-Nan; Xiang, Zheng-Hua; Yuan, Hong-Bin

2017-09-01

Increasing evidence suggests the potential involvement of metalloproteinase family proteins in the pathogenesis of neuropathic pain, although the underlying mechanisms remain elusive. Using the spinal nerve ligation model, we investigated whether ADAM10 proteins participate in pain regulation. By implementing invitro methods, we produced a purified culture of satellite glial cells to study the underlying mechanisms of ADAM10 in regulating neuropathic pain. Results showed that the ADAM10 protein was expressed in calcitonin gene-related peptide (CGRP)-containing neurons of the dorsal root ganglia, and expression was upregulated following spinal nerve ligation surgery invivo. Intrathecal administration of GI254023X, an ADAM10 selective inhibitor, to the rats one to three days after spinal nerve ligation surgery attenuated the spinal nerve ligation-induced mechanical allodynia and thermal hyperalgesia. Intrathecal injection of ADAM10 recombinant protein simulated pain behavior in normal rats to a similar extent as those treated by spinal nerve ligation surgery. These results raised a question about the relative contribution of ADAM10 in pain regulation. Further results showed that ADAM10 might act by cleaving E-cadherin, which is mainly expressed in satellite glial cells. GI254023X reversed spinal nerve ligation-induced downregulation of E-cadherin and activation of cyclooxygenase 2 after spinal nerve ligation. β-catenin, which creates a complex with E-cadherin in the membranes of satellite glial cells, was also downregulated by spinal nerve ligation surgery in satellite glial cells. Finally, knockdown expression of β-catenin by lentiviral infection in purified satellite glial cells increased expression of inducible nitric oxide synthase and cyclooxygenase 2. Our findings indicate that neuron-derived ADAM10 production stimulates peripheral nerve injury-induced neuropathic pain by cleaving E-cadherin in satellite glial cells. © 2017 American Academy of Pain Medicine

Residential Energy Efficiency Potential: Mississippi

Energy Technology Data Exchange (ETDEWEB)

Wilson, Eric J [National Renewable Energy Laboratory (NREL), Golden, CO (United States)

2017-11-22

Energy used by Mississippi single-family homes that can be saved through cost-effective improvements. Prepared by Eric Wilson and Noel Merket, NREL, and Erin Boyd, U.S. Department of Energy Office of Energy Policy and Systems Analysis.

Aquifer depletion in the Lower Mississippi River Basin: challenges and solutions

Science.gov (United States)

The Lower Mississippi River Basin (LMRB) is a nationally- and internationally-important region of intensive agricultural production that relies heavily on the underlying Mississippi River Valley Alluvial Aquifer (MRVAA) for row crop irrigation. Extensive irrigation coupled with the region’s geology ...

DYNAMIC ANALYSIS OF A CRIMPING DEVICE WITH MULTIPLE CAMS USING MSC ADAMS II

Directory of Open Access Journals (Sweden)

Gheorghe Popescu

2012-05-01

Full Text Available Through the present paper, the author presents the results of the dynamic analysis with MSC ADAMS of the mechanism with a crimping device with 12 tightening cams, designed and used in the technological process of assembly of the indigenous electrical detonators. In this sense, the mechanism with multiple cams is considered a mechanical system and is treated as an assembly of rigid bodies connected by mechanical connections and elastic elements. For shaping and simulation of the mechanism with multiple cams using ADAMS program, the author got through the following stages: construction of the pattern, its testing and simulation, validation, finishing, parametrization, optimization of the pattern.

Adam Smith y Sistemas Dinámicos

Directory of Open Access Journals (Sweden)

Osvaldo Acuña

2008-01-01

Full Text Available Presentamos un sistema dinámico sencillo con dos ecuaciones diferenciales, una representa la trayectoria del precio y la otra la de la cantidad de un bien en una economía. Nuestro modelo se basa sobre todo en la teoría clásica de precios expuesta por Adam Smith en La Riqueza de las Naciones. Al final del trabajo, se presenta, a modo de ejemplo, un estudio para el caso del ganado vacuno en la economía mundial.

Trends and Patterns of Differences in Chronic Respiratory Disease Mortality Among US Counties, 1980-2014.

Science.gov (United States)

Dwyer-Lindgren, Laura; Bertozzi-Villa, Amelia; Stubbs, Rebecca W; Morozoff, Chloe; Shirude, Shreya; Naghavi, Mohsen; Mokdad, Ali H; Murray, Christopher J L

2017-09-26

for chronic obstructive pulmonary disease and pneumoconiosis; widely dispersed throughout the Southwest, northern Great Plains, New England, and South Atlantic for interstitial lung disease; along the southern half of the Mississippi River and in Georgia and South Carolina for asthma; and in southern states from Mississippi to South Carolina for other chronic respiratory diseases. Despite recent declines in mortality from chronic respiratory diseases, mortality rates in 2014 remained significantly higher than in 1980. Between 1980 and 2014, there were important differences in mortality rates and changes in mortality by county, sex, and particular chronic respiratory disease type. These estimates may be helpful for informing efforts to improve prevention, diagnosis, and treatment.

Adam Smith e Francis Ysidro Edgeworth: uma crítica do utilitarismo

Directory of Open Access Journals (Sweden)

Solange Regina Marin

2012-01-01

Full Text Available Sugerimos, nesse trabalho, a investigação das concepções de Adam Smith e a de Francis Ysidro Edgeworth do utilitarismo. Ambas as concepções foram utilizadas para desenvolver a Ciência Econômica. Porém, também apresentaram as limitações da teoria econômica, cujas fronteiras vislumbradas pelos autores remetem para a necessidade de avaliar as ações e condutas humanas com teoria moral diferente do utilitarismo. Entendemos que a teoria moral de Adam Smith, esquecida pela história do pensamento econômico, se apresenta como alternativa e, em decorrência, uma ideia promissora para aperfeiçoar o estudo das ações e condutas ditas econômicas.

Co-simulation of Six DOF Wire Driven Parallel Mechanism Based on ADAMS and Matlab

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Tang Aofei

2015-01-01

Full Text Available The dynamic model of the 6 DOF Wire Driven Parallel Mechanism (WDPM system is introduced. Based on MATLAB system, the simulation of the inverse dynamic model is achieved. According to the simulation result, the mechanical model for the WDPM system is reasonable. Using ADAMS system, the dynamic model of the virtual prototype is verified by the simulation analysis. The combined control model based on ADAMS/Simulink is derived. The WDPM control system is designed with MATLAB/Simulink. The torque control method is selected for the outer ring and the PD control method for the inner ring. Combined with the ADAMS control model and control law design, the interactive simulation analysis of the WDPM system is completed. According to the simulation results of the spatial circle tracking and line tracking at the end of the moving platform, the tracking error can be reduced by the designed control algorithm. The minimum tracking error is 0.2 mm to 0.3 mm. Therefore, the theoretical foundation for designing hardware systems of the WDPM control system is established.

Aberrant Transforming Growth Factor β1 Signaling and SMAD4 Nuclear Translocation Confer Epigenetic Repression of ADAM19 in Ovarian Cancer

Directory of Open Access Journals (Sweden)

Michael W.Y. Chan

2008-09-01

Full Text Available Transforming growth factor-beta (TGF-β/SMAD signaling is a key growth regulatory pathway often dysregulated in ovarian cancer and other malignancies. Although loss of TGF-β–mediated growth inhibition has been shown to contribute to aberrant cell behavior, the epigenetic consequence(s of impaired TGF-β/SMAD signaling on target genes is not well established. In this study, we show that TGF-β1 causes growth inhibition of normal ovarian surface epithelial cells, induction of nuclear translocation SMAD4, and up-regulation of ADAM19 (a disintegrin and metalloprotease domain 19, a newly identified TGF-β1 target gene. Conversely, induction and nuclear translocation of SMAD4 were negligible in ovarian cancer cells refractory to TGF-β1 stimulation, and ADAM19 expression was greatly reduced. Furthermore, in the TGF-β1 refractory cells, an inactive chromatin environment, marked by repressive histone modifications (trimethyl-H3K27 and dimethyl-H3K9 and histone deacetylase, was associated with the ADAM19 promoter region. However, the CpG island found within the promoter and first exon of ADAM19 remained generally unmethylated. Although disrupted growth factor signaling has been linked to epigenetic gene silencing in cancer, this is the first evidence demonstrating that impaired TGF-β1 signaling can result in the formation of a repressive chromatin state and epigenetic suppression of ADAM19. Given the emerging role of ADAMs family proteins in growth factor regulation in normal cells, we suggest that epigenetic dysregulation of ADAM19 may contribute to the neoplastic process in ovarian cancer.

Water quality monitoring and data collection in the Mississippi sound

Science.gov (United States)

Runner, Michael S.; Creswell, R.

2002-01-01

The United States Geological Survey and the Mississippi Department of Marine Resources are collecting data on the quality of the water in the Mississippi Sound of the Gulf of Mexico, and streamflow data for its tributaries. The U.S. Geological Survey is collecting continuous water-level data, continuous and discrete water-temperature data, continuous and discrete specific-conductance data, as well as chloride and salinity samples at two locations in the Mississippi Sound and three Corps of Engineers tidal gages. Continuous-discharge data are also being collected at two additional stations on tributaries. The Mississippi Department of Marine Resources collects water samples at 169 locations in the Gulf of Mexico. Between 1800 and 2000 samples are collected annually which are analyzed for turbidity and fecal coliform bacteria. The continuous data are made available real-time through the internet and are being used in conjunction with streamflow data, weather data, and sampling data for the monitoring and management of the oyster reefs, the shrimp fishery and other marine species and their habitats.

Increased abundance of ADAM9 transcripts in the blood is associated with tissue damage [version 2; referees: 2 approved, 1 approved with reservations

Directory of Open Access Journals (Sweden)

Darawan Rinchai

2016-10-01

Full Text Available Background: Members of the ADAM (a disintegrin and metalloprotease domain family have emerged as critical regulators of cell-cell signaling during development and homeostasis. ADAM9 is consistently overexpressed in various human cancers, and has been shown to play an important role in tumorigenesis. However, little is known about the involvement of ADAM9 during immune-mediated processes. Results: Mining of an extensive compendium of transcriptomic datasets identified important gaps in knowledge regarding the possible role of ADAM9 in immunological homeostasis and inflammation: 1 The abundance of ADAM9 transcripts in the blood was increased in patients with acute infection but, 2 changed very little after in vitro exposure to a wide range of pathogen-associated molecular patterns (PAMPs. 3 Furthermore it was found to increase significantly in subjects as a result of tissue injury or tissue remodeling, in absence of infectious processes. Conclusions: Our findings indicate that ADAM9 may constitute a valuable biomarker for the assessment of tissue damage, especially in clinical situations where other inflammatory markers are confounded by infectious processes.

ADAM12 induces actin cytoskeleton and extracellular matrix reorganization during early adipocyte differentiation by regulating beta1 integrin function

DEFF Research Database (Denmark)

Kawaguchi, Nobuko; Sundberg, Christina; Kveiborg, Marie

2003-01-01

-100 from cells overexpressing ADAM12 than from control cells. Collectively, these results show that surface expression of ADAM12 impairs the function of beta1 integrins and, consequently, alters the organization of the actin cytoskeleton and extracellular matrix. These events may be necessary...

40 CFR 81.122 - Mississippi Delta Intrastate Air Quality Control Region.

Science.gov (United States)

2010-07-01

... Quality Control Region. 81.122 Section 81.122 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY... Air Quality Control Regions § 81.122 Mississippi Delta Intrastate Air Quality Control Region. The Mississippi Delta Intrastate Air Quality Control Region consists of the territorial area encompassed by the...

75 FR 76632 - Drawbridge Operation Regulation; Upper Mississippi River, Hannibal, MO

Science.gov (United States)

2010-12-09

... Operation Regulation; Upper Mississippi River, Hannibal, MO AGENCY: Coast Guard, DHS. ACTION: Notice of... temporary deviation from the regulation governing the operation of the Hannibal Railroad Drawbridge across the Upper Mississippi River, mile 309.9, at Hannibal, Missouri. The deviation is necessary to allow...

77 FR 28488 - Drawbridge Operation Regulation; Upper Mississippi River, Hannibal, MO

Science.gov (United States)

2012-05-15

... Operation Regulation; Upper Mississippi River, Hannibal, MO AGENCY: Coast Guard, DHS. ACTION: Notice of... operating schedule that governs the Hannibal Railroad Drawbridge across the Upper Mississippi River, mile 309.9, at Hannibal, Missouri. The deviation is necessary to allow the replacement of eight wire rope...

78 FR 64887 - Drawbridge Operation Regulation; Upper Mississippi River, Hannibal, MO

Science.gov (United States)

2013-10-30

... Operation Regulation; Upper Mississippi River, Hannibal, MO AGENCY: Coast Guard, DHS. ACTION: Notice of... operating schedule that governs the Hannibal Railroad Drawbridge across the Upper Mississippi River, mile 309.9, at Hannibal, Missouri. The deviation is necessary to allow the bridge owner time to replace...

Glyphosate-resistant goosegrass from Mississippi

Science.gov (United States)

A glyphosate resistant population of goosegrass (Eleusine indica (L.) Gaertn.) was documented near Stoneville, Mississippi, USA, in an area which had received multiple applications of glyphosate each year for the previous eleven years. Resistance ratios based on dose response growth reduction assays...

77 FR 38191 - Approval and Promulgation of Implementation Plans; State of Mississippi; Regional Haze State...

Science.gov (United States)

2012-06-27

... SIP submittal followed the VISTAS modeling protocol and considered the contribution of total PM 10 and... revisions to the Mississippi State Implementation Plan (SIP) submitted by the State of Mississippi through.... Mississippi's SIP revisions address regional haze for the first implementation period. Specifically, these SIP...

Characterization of 4-[18F]-ADAM as an imaging agent for SERT in non-human primate brain using PET: a dynamic study

International Nuclear Information System (INIS)

Chen, Yu-An; Huang, Wen-Sheng; Lin, Yaoh-Shiang; Cheng, Cheng-Yi; Liu, Ren-Shyan; Wang, Shyh-Jen; Li, I-Hsun; Huang, San-Yuan; Shiue, Chyng-Yann; Chen, Cheng-Yu; Ma, Kuo-Hsing

2012-01-01

Introduction: Serotonin transporter (SERT) has been associated with many psychiatric diseases. This study investigated the biodistribution of a serotonin transporter imaging agent, N,N-dimethyl-2-(2-amino-4- 18 F-fluorophenylthio)benzylamine (4-[ 18 F]-ADAM), in nonhuman primate brain using positron emission tomography (PET). Methods: Six and four Macaca cyclopis monkeys were used to determine the transit time (i.e., time necessary to reach biodistribution equilibrium) and the reproducibility of 4-[ 18 F]-ADAM biodistribution in the brain, respectively. The sensitivity and specificity of 4-[ 18 F]-ADAM binding to SERT were evaluated in one monkey challenged with different doses of fluoxetine and one monkey treated with 3,4-methylendioxymethamphetamine (MDMA). Dynamic PET imaging was performed for 3 h after 4-[ 18 F]-ADAM intravenous bolus injection. The specific uptake ratios (SURs) in the midbrain (MB), thalamus (TH), striatum (ST) and frontal cortex (FC) were calculated. Results: The distribution of 4-[ 18 F]-ADAM reached equilibrium 120–150 min after injection. The mean SURs were 2.49±0.13 in MB, 1.59±0.17 in TH, 1.35±0.06 in ST and 0.34±0.03 in FC, and the minimum variability was shown 120–150 min after 4-[ 18 F]-ADAM injection. Using SURs and intraclass coefficient of correlation, the test/retest variability was under 8% and above 0.8, respectively, in SERT-rich areas. Challenge with fluoxetin (0.75–2 mg) dose-dependently inhibited the SURs in various brain regions. 4-[ 18 F]-ADAM binding was markedly reduced in the brain of an MDMA-treated monkey compared to that in brains of normal controls. Conclusion: 4-[ 18 F]-ADAM appears to be a highly selective radioligand for imaging SERT in monkey brain.

Biodistribution study of [I-123] ADAM in mice brain using quantitative autoradiography

International Nuclear Information System (INIS)

Lin, K.J.; Yen, T.C.; Tzen, K.Y.; Ye, X.X.; Hwang, J.J.; Wey, S.P.; Ting, G.

2002-01-01

Aim: Autoradiography with radioluminography is a delicate method to characterize newly developed radiotracers and to apply them to pharmacological studies. Herein, we reported a biodistribution result of [I-123] ADAM (2-((2-((dimethylamino)methyl)phenyl)thio)-5- iodophenylamine) in mice brain quantitatively using imaging plates. Materials and Methods: 1mCi [I-123] ADAM was injected into male ICR mice through tail veins. Brains were removed at sequential time points ranging from 0.5hr to 4hr after injection. The whole brain was cut into 14mm thick coronal sections using a cyrotome. The sections were thaw-mounted on glass plate and apposed placed on an imaging plate with filter paper standards for 24 hours. Imaging reading was done by a Fuji FLA5000 device. Regions of interest were placed on the globus pallidus, hypothalamus, substantia nigra, raphe nuclei and cerebellum corresponding to the sterotaxic atlas, and the PSL/mm 2 values were measured. The specific binding was expressed as the ratios of (targets - cerebellum) to cerebellum. Results: Autoradiography study of brain showed that the [I-123] ADAM was accumulated at serotonin transporter rich sites, including the olfactory tubercle, globus pallidus, thalamus nuclei, hypothalamus, substantia nigra, interpeduncular nucleus, amygdala and raphe nuclei. Biodistribution of [I-123] ADAM in mice brain using quantitative autoradiography method showed a high specific binding in the substantia nigra and hypothalamus and the time-activity curve peaked at 120 min post-injection. Compatible specific binding result was achieved in the region of hypothalamus as compared with previous study by other group using conventional tissue micro-dissection method (Synapse 38:403-412, 2000). However, higher specific binding was observed in certain small brain regions including substantia nigra, raphe nuclei due to improved spatial resolution of the quantitative autoradiography technique. Conclusion: Our result showed that the

76 FR 53436 - Free Flow Power Corporation; Northland Power Mississippi River LLC; Notice of Competing...

Science.gov (United States)

2011-08-26

... Mississippi River, near the town of Luling, in St. Charles Parish, Louisiana. The sole purpose of a.... 14091-000] Free Flow Power Corporation; Northland Power Mississippi River LLC; Notice of Competing... Mississippi River LLC (Northland) filed preliminary permit applications, pursuant to section 4(f) of the...

76 FR 53427 - Free Flow Power Corporation; Northland Power Mississippi River LLC; Notice of Competing...

Science.gov (United States)

2011-08-26

... Mississippi River, near the town of Killona, in St. Charles Parish, Louisiana. The sole purpose of a.... 14092-000] Free Flow Power Corporation; Northland Power Mississippi River LLC; Notice of Competing... Mississippi River LLC (Northland) filed preliminary permit applications, pursuant to section 4(f) of the...

ADAM 12 may be used to reduce the false positive rate of first trimester combined screening for Down syndrome

DEFF Research Database (Denmark)

Christiansen, Michael; Pihl, Kasper; Hedley, Paula L.

2010-01-01

BACKGROUND: ADAM12 has been shown to be an efficient maternal serum marker for Down syndrome (DS) in the first trimester; but recent studies, using a second generation assay, have not confirmed these findings. We examined the efficiency of a second generation assay for ADAM12. MATERIALS AND METHODS...

Sir John Adams: his legacy to the world of particle accelerators

CERN Document Server

Wilson, E J N

2011-01-01

John Adams acquired an unrivalled reputation for his leading part in designing and constructing the Proton Synchrotron (PS) in CERN’s early days. In 1968, and after several years heading a fusion laboratory in the UK, he came back to Geneva to pilot the Super Proton Synchrotron (SPS) project to approval and then to direct its construction. By the time of his early death in 1984 he had built the two flagship proton accelerators at CERN and, during the second of his terms as Director-General, he laid the groundwork for the proton–antiproton collider which led to the discovery of the intermediate vector boson. How did someone without any formal academic qualification achieve this? What was the magic behind his leadership? The speaker, who worked many years alongside him, will discuss these questions and speculate on how Sir John Adams might have viewed today’s CERN.

Identification of binding peptides of the ADAM15 disintegrin domain ...

Indian Academy of Sciences (India)

Madhsudhan

ADAM15 disintegrin domain (RADD) that could inhibit melanoma cell adhesion by using Escherichia coli. Second, four specific binding peptides (peptides A, B, C, and D) were selected using a phage display 12-mer peptide library. The screening protocol involved 4 rounds of positive panning on RADD and 2 rounds of ...

75 FR 28612 - Environmental Impact Statements; Notice of Availability

Science.gov (United States)

2010-05-21

... Counties, OR and Adams and Nez Perce Counties, ID, Wait Period Ends: 06/21/2010, Contact: Robert W. Rock.... EIS No. 20100181, Final EIS, DOE, MS, Kemper County Integrated Gasification Combined-Cycle (IGCC...

Adam M. Grant: Award for Distinguished Scientific Early Career Contributions to Psychology.

Science.gov (United States)

2011-11-01

Presents Adam M. Grant, the 2011 winner of the American Psychological Association Award for Distinguished Scientific Early Career Contributions to Psychology. "For extensive, elegant, and programmatic research on the power of relational job design in enhancing employee motivation, productivity, and satisfaction; for creative and rigorous studies documenting the profound and surprising effects of connecting employees to their impact on others; for highlighting prosocial motivation, not only extrinsic and intrinsic motivations, as a key force behind employee behavior; and for demonstrating by example the feasibility and benefits of conducting field experiments, yielding studies rich in internal validity, external validity, and practical impact. In addition to his accomplishments, Adam M. Grant is known for his generosity as a scholar, teacher, and colleague." (PsycINFO Database Record (c) 2011 APA, all rights reserved). 2011 APA, all rights reserved

The Invisible Hand of God in Adam Smith

OpenAIRE

Denis, A.

2005-01-01

Adam Smith is revered as the father of modern economics. Analysis of his writings, however, reveals a profoundly medieval outlook. Smith is preoccupied with the need to preserve order in society. His scientific methodology emphasises reconciliation with the world we live in rather than investigation of it. He invokes a version of natural law in which the universe is a harmonious machine administered by a providential deity. Nobody is uncared for and, in real happiness, we are all substantiall...

Aerial gamma ray and magnetic survey: Mississippi and Florida airborne survey, Jackson quadrangle of Mississippi and Louisiana. Final report

International Nuclear Information System (INIS)

1980-07-01

The Jackson quadrangle covers a region largely within the Mississippi River flood plain. In the extreme northern Gulf Coastal Physiographic Province. Underlying Mesozoic and Cenozoic sediments of the Mississippi Embayment are relatively thick. Exposed sediments are largely Quaternary in age, though older Cenozoic material of both marine and nonmarine origin are exposed in areas adjacent to the flood plain in the east. A search of the available literature revealed no known uranium deposits. Seventy-three uranium anomalies were detected and are discussed briefly. None were considered significant, and most appeared to be of cultural origin. Magnetic data appears to be in agreement with existing structural interpretations of the region

In vivo quantification by SPECT of [{sup 123}I] ADAM bound to serotonin transporters in the brains of rabbits

Energy Technology Data Exchange (ETDEWEB)

Ye, X.-X. [Institute of Radiological Sciences, National Yang-Ming University, Taipei 112, Taiwan (China); Hwang, J.-J. [Institute of Radiological Sciences, National Yang-Ming University, Taipei 112, Taiwan (China); Hsieh, J.-F. [Department of Nuclear Medicine, Chi-Mei Foundation Medical Center, Yungkang City 710, Taiwan (China); Chen, J.-C. [Institute of Radiological Sciences, National Yang-Ming University, Taipei 112, Taiwan (China)]. E-mail: jcchen@ym.edu.tw; Chou, Y.-T. [Institute of Physiology, National Yang-Ming University, Taipei 112, Taiwan (China); Tu, K.-Y. [Department of Nuclear Medicine, Mackey Memorial Hospital, Taipei, Taiwan 104 (China); Wey, S.-P. [Department of Medical Imaging and Radiological Sciences, Chang-Gung University, Taoyuan, Taiwan 333 (China); Ting Gann [Institute of Nuclear Energy Research, Tao- Yuan 335, Taiwan (China)

2004-11-01

Background: A novel radioiodine ligand [{sup 123}I] ADAM (2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine) has been suggested as a promising serotonin transporter (SERT) imaging agent for the central nervous system. In this study, the biodistribution of SERTs in the rabbit brain was investigated using [{sup 123}I] ADAM and mapping images of the same animal produced by both single-photon emission computed tomography (SPECT) and microautoradiography. A semiquantification method was adopted to deduce the optimum time for SPECT imaging, whereas the input for a simple fully quantitative tracer kinetic model was provided from arterial blood sampling data. Methods: SPECT imaging was performed on female rabbits postinjection of 185 MBq [{sup 123}I] ADAM. The time-activity curve obtained from the SPECT images was used to quantify the SERTs, for which the binding potential was calculated from the kinetic modeling of [{sup 123}I] ADAM. The kinetic data were analyzed by the nonlinear least squares method. The effects of the selective serotonin reuptake inhibitors fluoxetine and p-chloroamphetamine (PCA) on rabbits were also evaluated. After scanning, the same animal was sacrificed and the brain was removed for microautoradiography. Regions-of-interest were analyzed using both SPECT and microautoradiography images. The SPECT images were coregistered manually with the corresponding microautoradiography images for comparative study. Results: During the time interval 90-100 min postinjection, the peak specific binding levels in different brain regions were compared and the brain stem was shown to have the highest activity. The target-to-background ratio was 1.89{+-}0.02. Similar studies with fluoxetine and PCA showed a background level for SERT occupation. Microautoradiography demonstrated a higher level of anatomical details of the [{sup 123}I] ADAM distribution than that obtained by SPECT imaging of the rabbit brain. Conclusion: SPECT imaging of the rabbit brain with

The role of polymorphisms in ADAM33, a disintegrin and metalloprotease 33, in childhood asthma and lung function in two German populations

Directory of Open Access Journals (Sweden)

Klopp Norman

2006-06-01

Full Text Available Abstract Background ADAM33, the first asthma candidate gene identified by positional cloning, may be associated with childhood asthma, lung function decline and bronchial hyperresponsiveness. However, replication results have been inconclusive in smaller previous study populations probably due to inconsistencies in asthma phenotypes or yet unknown environmental influences. Thus, we tried to further elucidate the role of ADAM33 polymorphisms (SNPs in a genetic analysis of German case control and longitudinal populations. Methods Using MALDI-TOF, ten ADAM33 SNPs were genotyped in 1,872 children from the International Study of Asthma and Allergy in Childhood (ISAAC II in a case control setting and further 824 children from the longitudinal cohort Multicentre Study of Allergy (MAS. In both populations the effects of single SNPs and haplotypes were studied and a gene environment analysis with passive smoke exposure was performed using SAS/Genetics. Results No single SNP showed a significant association with doctor's diagnosis of asthma. A trend for somewhat more profound effects of ADAM33 SNPs was observed in individuals with asthma and BHR. Haplotype analyses suggested a minor effect of the ADAM33 haplotype H4 on asthma (p = 0.033 but not on BHR. Associations with non atopic asthma and baseline lung function were identified but no interaction with passive smoke exposure could be detected. Conclusion The originally reported association between ADAM33 polymorphisms and asthma and BHR could not be confirmed. However, our data may suggest a complex role of ADAM33 polymorphisms in asthma ethiology, especially in non atopic asthma.

The SPECT tracer [{sup 123}I]ADAM binds selectively to serotonin transporters: a double-blind, placebo-controlled study in healthy young men

Energy Technology Data Exchange (ETDEWEB)

Giessen, Elsmarieke van de [University of Amsterdam, Academic Medical Center, Graduate School Neurosciences Amsterdam, Department of Nuclear Medicine, Amsterdam (Netherlands); Booij, Jan [University of Amsterdam, Academic Medical Center, Graduate School Neurosciences Amsterdam, Department of Nuclear Medicine, Amsterdam (Netherlands); University of Amsterdam, Academic Medical Center, Department of Nuclear Medicine, F2-236, Amsterdam (Netherlands)

2010-08-15

The tracer {sup 123}I-2-([2-({l_brace}dimethylamino{r_brace}methyl)phenyl]thio)-5-iodophenylamine ([{sup 123}I]ADAM) has been developed to image serotonin transporters (SERTs) with SPECT. Preclinical studies have shown that [{sup 123}I]ADAM binds selectively to SERTs. Moreover, initial human studies have shown that [{sup 123}I]ADAM binding could be blocked by selective serotonin reuptake inhibitors (SSRIs). However, in humans it has not been proven that [{sup 123}I]ADAM binds selectively to SERTs. We examined the in vivo availability of SERTs in 12 healthy young volunteers 5 h after bolus injection of [{sup 123}I]ADAM. To evaluate the selectivity of binding, four participants were pretreated (double-blinded design) with placebo, four with paroxetine (20 mg) and four with the dopamine/norepinephrine blocker methylphenidate (20 mg). SPECT studies were performed on a brain-dedicated system (Neurofocus), and the SPECT images were coregistered with individual MR scans of the brain. ADAM binding in SERT-rich brain areas and cerebellar cortex (representing non-specific binding) was assessed by drawing regions of interest (ROIs) on the individual MR images. Specific to non-specific ratios were used as the outcome measure. We found that specific to non-specific ratios were statistically significantly lower in paroxetine-pretreated participants than in placebo- or methylphenidate-pretreated participants. No such difference was found between groups pretreated with placebo or methylphenidate. Our preliminary findings suggest that [{sup 123}I]ADAM binds selectively to SERTs in human brain. (orig.)

Employment Discrimination Based on Sexual Orientation and Gender Identity in Mississippi

OpenAIRE

Mallory, Christy; Sears, Brad

2015-01-01

Approximately 34,800 LGBT workers in Mississippi are not explicitly protected from discrimination under state or local laws. Discrimination against LGBT employees has been documented in surveys, media reports, and court cases. Many corporate employers and public opinion in Mississippi support protections for LGBT people in the workplace. 

Two Rival Conceptions of Vocational Education: Adam Smith and Friedrich List.

Science.gov (United States)

Winch, Christopher

1998-01-01

Examines and discusses two views of political economy: (1) the classical model of Adam Smith; and (2) the social capitalist model associated with Friedrich List. Explores two varieties of vocational education and training that emerge from a comparison of Smith's and List's ideas. (CMK)

Hazardous materials in aquatic environments of the Mississippi River Basin

International Nuclear Information System (INIS)

1993-01-01

Tulane and Xavier Universities have singled out the environment as a major strategic focus for research and training for now and by the year 2000. In December, 1992, the Tulane/Xavier CBR was awarded a five year grant to study pollution in the Mississippi River system. The ''Hazardous Materials in Aquatic Environments of the Mississippi River Basin'' project is a broad research and education program aimed at elucidating the nature and magnitude of toxic materials that contaminate aquatic environments of the Mississippi River Basin. Studies include defining the complex interactions that occur during the transport of contaminants, the actual and potential impact on ecological systems and health, and the mechanisms through which these impacts might be remediated. The Mississippi River Basin represents a model system for analyzing and solving contamination problems that are found in aquatic systems world-wide. These research and education projects are particularly relevant to the US Department of Energy's programs aimed at addressing aquatic pollution problems associated with DOE National Laboratories. First year funding supported seven collaborative cluster projects and twelve initiation projects. This report summarizes research results for period December 1992--December 1993

Adam Smith and the Moral Economy of the Classroom System.

Science.gov (United States)

Hamilton, D.

1980-01-01

Traces the development of mass schooling to its origins in 19th-century Glasgow. Its importance as an intellectual and economic center enabled Glasgow to invent a solution to the problem of urban schooling, while the association of scholars like Adam Smith with Glasgow University made Scottish educational theories acceptable around the world. (DB)

Development of A Mississippi River Alluvial Aquifer Groundwater Model

Science.gov (United States)

Karakullukcu, R. E.; Tsai, F. T. C.; Bhatta, D.; Paudel, K.; Kao, S. C.

2017-12-01

The Mississippi River Alluvial Aquifer (MRAA) underlies the Mississippi River Valley of the northeastern Louisiana, extending from the north border of Louisiana and Arkansas to south central of Louisiana. The MRAA has direct contact with the Mississippi River. However, the interaction between the Mississippi River and the alluvial aquifer is largely unknown. The MRAA is the second most used groundwater source in Louisiana's aquifers with about 390 million gallons per day, which is about 25% of all groundwater withdrawals in Louisiana. MRAA is the major water source to agriculture in the northeastern Louisiana. The groundwater withdrawals from the MRAA increases annually for irrigation. High groundwater pumping has caused significant groundwater level decline and elevated salinity in the aquifer. Therefore, dealing with agricultural irrigation is the primary purpose for managing the MRAA. The main objective of this study is to develop a groundwater model as a tool for the MRAA groundwater management. To do so, a hydrostratigraphy model of the MRAA was constructed by using nearly 8,000 drillers' logs and electric logs collected from Louisiana Department of Natural Resources. The hydrostratigraphy model clearly shows that the Mississippi River cuts into the alluvial aquifer. A grid generation technique was developed to convert the hydrostratigraphy model into a MODFLOW model with 12 layers. A GIS-based method was used to estimate groundwater withdrawals for irrigation wells based on the crop location and acreage from the USDACropScape - Cropland Data Layer. Results from the Variable Infiltration Capacity (VIC) model were used to determine potential recharge. NHDPlusV2 data was used to determine water level for major streams for the MODFLOW River Package. The groundwater model was calibrated using groundwater data between 2004 and 2015 to estimate aquifer hydraulic conductivity, specific yield, specific storage, river conductance, and surficial recharge.

Remote Sensing of Suspended Sediment Dynamics in the Mississippi Sound

Science.gov (United States)

Merritt, D. N.; Skarke, A. D.; Silwal, S.; Dash, P.

2016-02-01

The Mississippi Sound is a semi-enclosed estuary between the coast of Mississippi and a chain of offshore barrier islands with relatively shallow water depths and high marine biodiversity that is wildly utilized for commercial fishing and public recreation. The discharge of sediment-laden rivers into the Mississippi Sound and the adjacent Northern Gulf of Mexico creates turbid plumes that can extend hundreds of square kilometers along the coast and persist for multiple days. The concentration of suspended sediment in these coastal waters is an important parameter in the calculation of regional sediment budgets as well as analysis of water-quality factors such as primary productivity, nutrient dynamics, and the transport of pollutants as well as pathogens. The spectral resolution, sampling frequency, and regional scale spatial domain associated with satellite based sensors makes remote sensing an ideal tool to monitor suspended sediment dynamics in the Northern Gulf of Mexico. Accordingly, the presented research evaluates the validity of published models that relate remote sensing reflectance with suspended sediment concentrations (SSC), for similar environmental settings, with 51 in situ observations of SSC from the Mississippi Sound. Additionally, regression analysis is used to correlate additional in situ observations of SSC in Mississippi Sound with coincident observations of visible and near-infrared band reflectance collected by the Moderate Resolution Imaging Spectroradiometer (MODIS) sensor aboard the Aqua satellite, in order to develop a site-specific empirical predictive model for SSC. Finally, specific parameters of the sampled suspended sediment such as grain size and mineralogy are analyzed in order to quantify their respective contributions to total remotely sensed reflectance.

An Analysis of Corporal Punishment Practices in the State of Mississippi

Science.gov (United States)

Williams-Damond, Twyla A.

2014-01-01

The focus of this research mainly centers on a quantitative descriptive overview of corporal punishment practices in the state of Mississippi, but this study also includes a legal document analysis component. This study forms the Mississippi portion of a comprehensive analysis of the demographics of corporal punishment in the public schools of the…

Susceptibility of ground water to surface and shallow sources of contamination in Mississippi

Science.gov (United States)

O'Hara, Charles G.

1996-01-01

Ground water, because of its extensive use in agriculture, industry, and public-water supply, is one of Mississippi's most important natural resources.  Ground water is the source for about 80 percent of the total freshwater used by the State's population (Solley and others, 1993).  About 2,600 Mgal/d of freshwater is withdrawn from aquifers in Mississippi (D.E. Burt, Jr., U.S. Geological Survey, oral commun., 1995).  Wells capable of yielding 200 gal/min of water with quality suitable for most uses can be developed nearly anywhere in the State (Bednar, 1988).  The U.S. Geological Survey (USGS), in cooperation with the Mississippi Department of Environmental Quality, Office of Pollution Control, and the Mississippi Department of Agriculture and Commerce, Bureau of Plant Industry, conducted an investigation to evaluate the susceptibility of ground water to contamination from surgace and shallow sources in Mississippi.  A geographic information system (GIS) was used to develop and analyze statewide spatial data layers that contain geologic, hydrologic, physiographic, and cultural information.

Ecosystem effects in the Lower Mississippi River Basin: Chapter L in 2011 Floods of the Central United States

Science.gov (United States)

Turnipseed, D. Phil; Allen, Yvonne C.; Couvillion, Brady R.; McKee, Karen L.; Vervaeke, William C.

2014-01-01

The 2011 Mississippi River flood in the Lower Mississippi River Basin was one of the largest flood events in recorded history, producing the largest or next to largest peak streamflow for the period of record at a number of streamgages on the lower Mississippi River. Ecosystem effects include changes to wetlands, nutrient transport, and land accretion and sediment deposition changes. Direct effects to the wetland ecosystems in the Lower Mississippi River Basin were minimized because of the expansive levee system built to pass floodwaters. Nutrients carried by the Mississippi River affect water quality in the Lower Mississippi River Basin. During 2011, nutrient fluxes in the lower Mississippi River were about average. Generally, nutrient delivery of the Mississippi and Atchafalaya Rivers contributes to the size of the hypoxic zone in the Gulf of Mexico. Based on available limited post-flood satellite imagery, some land expansion in both the Wax Lake and Atchafalaya River Deltas was observed. A wetland sediment survey completed in June 2011 indicated that recent sediment deposits were relatively thicker in the Atchafalaya and Mississippi River (Birdsfoot) Delta marshes compared to marshes farther from these rivers.

Wetland Management Reduces Sediment and Nutrient Loading to the Upper Mississippi River

Science.gov (United States)

Restored riparian wetlands in the Upper Mississippi River basin have the potential to remove sediment and nutrients from tributaries before they flow into the Mississippi River. For 3 yr we calculated retention efficiencies of a marsh complex, which consisted of a restored marsh...

78 FR 28002 - In the Matter of South Mississippi Electric Power Association, System Energy Resources, Inc...

Science.gov (United States)

2013-05-13

... of South Mississippi Electric Power Association, System Energy Resources, Inc., Grand Gulf Nuclear... Amendment I South Mississippi Electric Power Association, System Energy Resources, Inc. (SERI), Entergy... Operating License No. NPF-29. South Mississippi Electric Power Association and SERI are the owners and EOI...

Adam Smith’s irony and the Invisible Hand

OpenAIRE

Cremaschi, Sergio

2017-01-01

I reconstruct Adam Smith’s theory of irony and its application. I illustrate how he defines it as a combination of something “grand” with something “mean” and how this is consistent with his anti-Cartesian and post-sceptic epistemology. I suggest that, for Smith, “systems” of any kind, from Cartesian physics to philosophical monotheism, Stoic ethics, and the “mercantile system” draw their apparent plausibility from some disease of human imagination. I argue that in every field, including poli...

Father Knows Best: Using Adam Smith to Teach Transactions Costs

Science.gov (United States)

Dupont, Brandon

2014-01-01

Adam Smith's moral philosophy can be used to introduce economics students to the important idea of transactions costs. The author provides a brief background in this article to Smith's moral philosophy and connects it to the costs of transacting in a way that fits easily into the standard principles of microeconomics classroom. By doing…

Influence of mannosylation on immunostimulating activity of adamant-1-yl tripeptide.

Science.gov (United States)

Ribić, Rosana; Habjanec, Lidija; Frkanec, Ruža; Vranešić, Branka; Tomić, Srđanka

2012-07-01

The mannosylated derivative of adamant-1-yl tripeptide (D-(Ad-1-yl)Gly-L-Ala-D-isoGln) was prepared to study the effects of mannosylation on adjuvant (immunostimulating) activity. Mannosylated adamant-1-yl tripeptide (Man-OCH(2) CH(Me)CO-D-(Ad-1-yl)Gly-L-Ala-D-isoGln) is a non-pyrogenic, H(2) O-soluble, and non-toxic compound. Adjuvant activity of mannosylated adamantyl tripeptide was tested in the mouse model with ovalbumin as an antigen and in comparison to the parent tripeptide and peptidoglycan monomer (PGM, β-D-GlcNAc-(1→4)-D-MurNAc-L-Ala-D-isoGln-mesoDAP(εNH(2) )-D-Ala-D-Ala), a well-known effective adjuvant. The mannosylation of adamantyl tripeptide caused the amplification of its immunostimulating activity in such a way that it was comparable to that of PGM. Copyright © 2012 Verlag Helvetica Chimica Acta AG, Zürich.

SuperADAM: upgraded polarized neutron reflectometer at the Institut Laue-Langevin.

Science.gov (United States)

Devishvili, A; Zhernenkov, K; Dennison, A J C; Toperverg, B P; Wolff, M; Hjörvarsson, B; Zabel, H

2013-02-01

A new neutron reflectometer SuperADAM has recently been built and commissioned at the Institut Laue-Langevin, Grenoble, France. It replaces the previous neutron reflectometer ADAM. The new instrument uses a solid state polarizer/wavelength filter providing a highly polarized (up to 98.6%) monochromatic neutron flux of 8 × 10(4) n cm(-2) s(-1) with monochromatization Δλ∕λ = 0.7% and angular divergence Δα = 0.2 mrad. The instrument includes both single and position sensitive detectors. The position sensitive detector allows simultaneous measurement of specular reflection and off-specular scattering. Polarization analysis for both specular reflection and off-specular scattering is achieved using either mirror analyzers or a (3)He spin filter cell. High efficiency detectors, low background, and high flux provides a dynamic range of up to seven decades in reflectivity. Detailed specifications and the instrument capabilities are illustrated with examples of recently collected data in the fields of thin film magnetism and thin polymer films.

Cost-Effectiveness Analysis of the Residential Provisions of the 2015 IECC for Mississippi

Energy Technology Data Exchange (ETDEWEB)

Mendon, Vrushali V. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Zhao, Mingjie [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Taylor, Zachary T. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States); Poehlman, Eric A. [Pacific Northwest National Lab. (PNNL), Richland, WA (United States)

2016-02-15

The 2015 IECC provides cost-effective savings for residential buildings in Mississippi. Moving to the 2015 IECC from the 2009 IECC base code is cost-effective for residential buildings in all climate zones in Mississippi.

U. Mississippi program ups physics interests

CERN Multimedia

Carrington, E

2002-01-01

The University of Mississippi is one of the 44 national sites taking part in QuarkNet, a national program that provides high school teachers with the opportunity to work with university researchers on physics research (1/2 page).

Comparing Adam Smith's Wealth of Nations to James Madison's Federalist #10.

Science.gov (United States)

Mundell, Jean

1987-01-01

Presents a lesson which calls upon students to compare Adam Smith's WEALTH OF NATIONS to James Madison's FEDERALIST #10 to see how the ancient concept of individual rights and liberties was used to describe both economic and governmental systems. Presents questions to provide the basis for comparison. (GEA)

Trends in suspended-sediment loads and concentrations in the Mississippi River Basin, 1950–2009

Science.gov (United States)

Heimann, David C.; Sprague, Lori A.; Blevins, Dale W.

2011-01-01

Trends in loads and concentrations of suspended sediment and suspended sand generally were downward for stations within the Mississippi River Basin during the 60-, 34-, and 12-year periods analyzed. Sediment transport in the lower Mississippi River has historically been, and continues to be, most closely correlative to sediment contributions from the Missouri River, which generally carried the largest annual suspended-sediment load of the major Mississippi River subbasins. The closure of Fort Randall Dam in the upper Missouri River in 1952 was the single largest event in the recorded historical decline of suspended-sediment loads in the Mississippi River Basin. Impoundments on tributaries and sediment reductions as a result of implementation of agricultural conservation practices throughout the basin likely account for much of the remaining Mississippi River sediment transport decline. Scour of the main-stem channel downstream from the upper Missouri River impoundments is likely the largest source of suspended sand in the lower Missouri River. The Ohio River was second to the Missouri River in terms of sediment contributions, followed by the upper Mississippi and Arkansas Rivers. Declines in sediment loads and concentrations continued through the most recent analysis period (1998–2009) at available Mississippi River Basin stations. Analyses of flow-adjusted concentrations of suspended sediment indicate the recent downward temporal changes generally can be explained by corresponding decreases in streamflows.

Mississippi burnout part II: satisfaction, autonomy and work/family balance.

Science.gov (United States)

Cossman, Jeralynn S; Street, Debra

2009-10-01

Documented Mississippi physician shortages' make evidence about factors shaping physicians' career choices especially important if Mississippi policymakers are to devise workable strategies to maximize the physician workforce. Work-life interactions influence physicians' choices about how they manage their careers and professional burnout is one documented cause of physicians' decisions to change work hours or to choose early retirement. We find that women and mid-career physicians are more likely than men or later career physicians to experience stress and burnout. Additionally, physicians who experience burnout are less likely to report being satisfied with nearly every aspect of their professional life and work-life balance indicating that burnout permeates several dimensions of physicians' lives. The associations in our findings are suggestive; however, to minimize deleterious effects of burnout on the Mississippi physician workforce, future research should examine the causal factors underlying stress and burnout.

Midcycle evaluation of Mississippi timber resources

Science.gov (United States)

Dwane D. Van Hooser

1973-01-01

Between 1967 and 1972 forest acreage in Mississippi decreased by 1 percent, but softwood volume increased by 10 percent and hardwood by 6 percent. More than 0.5 billion cubic feet of roundwood were harvested from the State's forests in 1972.

77 FR 61592 - Arkansas Electric Cooperative Corporation; Mississippi Delta Energy Agency; Clarksdale Public...

Science.gov (United States)

2012-10-10

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. EL12-110-000] Arkansas Electric Cooperative Corporation; Mississippi Delta Energy Agency; Clarksdale Public Utilities Commission.... 825(h), Arkansas Electric Cooperative Corporation, Mississippi Delta Energy Agency, and its two...

Back to Beginnings: Credentialism, Productivity, and Adam Smith's Division of Labour.

Science.gov (United States)

Davis, Denis J.

1981-01-01

The foundation of factional pressures for upgrading educational credentials in the labor market is examined through a review of human capital and screening theories. The writings of Adam Smith are referenced to show that the claims of the beneficial effects of educational upgrading have been questioned for 200 years. (Author/MLW)

78 FR 69995 - Drawbridge Operation Regulation; Upper Mississippi River, Rock Island, IL

Science.gov (United States)

2013-11-22

... Operation Regulation; Upper Mississippi River, Rock Island, IL AGENCY: Coast Guard, DHS. ACTION: Notice of... operating schedule that governs the Rock Island Railroad and Highway Drawbridge across the Upper Mississippi River, mile 482.9, at Rock Island, Illinois. The deviation is necessary to allow the bridge owner time...

Helicopter magnetic and electromagnetic surveys at Mounts Adams, Baker and Rainier, Washington: implications for debris flow hazards and volcano hydrology

Science.gov (United States)

Finn, Carol A.; Deszcz-Pan, Maria

2011-01-01

High‐resolution helicopter magnetic and electromagnetic (HEM) data flown over the rugged, ice‐covered Mt. Adams, Mt. Baker and Mt. Rainier volcanoes (Washington), reveal the distribution of alteration, water and ice thickness essential to evaluating volcanic landslide hazards. These data, combined with geological mapping and rock property measurements, indicate the presence of appreciable thicknesses (>500 m) of water‐saturated hydrothermally altered rock west of the modern summit of Mount Rainier in the Sunset Amphitheater region and in the central core of Mount Adams north of the summit. Alteration at Mount Baker is restricted to thinner (<300 m) zones beneath Sherman Crater and the Dorr Fumarole Fields. The EM data identified water‐saturated rocks from the surface to the detection limit (100–200 m) in discreet zones at Mt. Rainier and Mt Adams and over the entire summit region at Mt. Baker. The best estimates for ice thickness are obtained over relatively low resistivity (<800 ohm‐m) ground for the main ice cap on Mt. Adams and over most of the summit of Mt. Baker. The modeled distribution of alteration, pore fluids and partial ice volumes on the volcanoes helps identify likely sources for future alteration‐related debris flows, including the Sunset Amphitheater region at Mt. Rainier, steep cliffs at the western edge of the central altered zone at Mount Adams and eastern flanks of Mt. Baker.

50 CFR 32.43 - Mississippi.

Science.gov (United States)

2010-10-01

... Hunter Education Safety Course card or certificate. You may obtain permits at North Mississippi Refuges.... Youth hunters age 15 and under must possess and carry a hunter safety course card or certificate. Each... roads designated as vehicle access roads on the refuge map (see § 27.31 of this chapter). We prohibit...

Mississippi Ethanol Gasification Project, Final Scientific / Technical Report

Energy Technology Data Exchange (ETDEWEB)

Pearson, Larry, E.

2007-04-30

The Mississippi Ethanol (ME) Project is a comprehensive effort to develop the conversion of biomass to ethanol utilizing a proprietary gasification reactor technology developed by Mississippi Ethanol, LLC. Tasks were split between operation of a 1/10 scale unit at the Diagnostic Instrumentation and Analysis Laboratory (DIAL) of Mississippi State University (MSU) and the construction, development, and operation of a full scale pilot unit located at the ME facility in Winona, Mississippi. In addition to characterization of the ME reactor gasification system, other areas considered critical to the operational and economic viability of the overall ME concept were evaluated. These areas include syngas cleanup, biological conversion of syngas to alcohol, and effects of gasification scale factors. Characterization of run data from the Pre-Pilot and Pilot Units has allowed development of the factors necessary for scale-up from the small unit to the larger unit. This scale range is approximately a factor of 10. Particulate and tar sampling gave order of magnitude values for preliminary design calculations. In addition, sampling values collected downstream of the ash removal system show significant reductions in observed loadings. These loading values indicate that acceptable particulate and tar loading rates could be attained with standard equipment additions to the existing configurations. Overall operation both the Pre-Pilot and Pilot Units proceeded very well. The Pilot Unit was operated as a system, from wood receiving to gas flaring, several times and these runs were used to address possible production-scale concerns. Among these, a pressure feed system was developed to allow feed of material against gasifier system pressure with little or no purge requirements. Similarly, a water wash system, with continuous ash collection, was developed, installed, and tested. Development of a biological system for alcohol production was conducted at Mississippi State University with

[11C]SMe-ADAM, an imaging agent for the brain serotonin transporter: synthesis, pharmacological characterization and microPET studies in rats

International Nuclear Information System (INIS)

Zessin, Joerg; Deuther-Conrad, Winnie; Kretzschmar, Marion; Wuest, Frank; Pawelke, Beate; Brust, Peter; Steinbach, Joerg; Bergmann, Ralf

2006-01-01

N,N-Dimethyl-2-(2-amino-4-methylthiophenylthio)benzylamine (S Me-Adam, 1) is a highly potent and selective inhibitor of the serotonin transporter (SPERT). This compound was labeled with carbon-11 by methylation of the S-desmethyl precursor 10 with [ 11 C]methyl iodide to obtain the potential positron emission tomography (PET) radioligand [ 11 C]S Me-Adam. The radiochemical yield was 27±5%, and the specific radioactivity was 26-40 GBq/μmol at the end of synthesis. Ex vivo and in vivo biodistribution experiments in rats demonstrated a rapid accumulation of the radiotracer in brain regions known to be rich in SPERT, such as the thalamus/hypothalamus region (3.59±0.41%ID/g at 5 min after injection). The specific uptake reached a thalamus to cerebellum ratio of 6.74±0.95 at 60 min postinjection. The [ 11 C]SMe-ADAM uptake in the thalamus was significantly decreased by pretreatment with fluoxetine to 38±11% of the control value. Furthermore, no metabolites of [ 11 C]SMe-ADAM could be detected in the SERT-rich regions of the rat brain. It is concluded that [ 11 C]SMe-ADAM may be a suitable PET ligand for SERT imaging in the living brain

[11C]SMe-ADAM, an imaging agent for the brain serotonin transporter: synthesis, pharmacological characterization and microPET studies in rats.

Science.gov (United States)

Zessin, Jörg; Deuther-Conrad, Winnie; Kretzschmar, Marion; Wüst, Frank; Pawelke, Beate; Brust, Peter; Steinbach, Jörg; Bergmann, Ralf

2006-01-01

N,N-Dimethyl-2-(2-amino-4-methylthiophenylthio)benzylamine (SMe-ADAM, 1) is a highly potent and selective inhibitor of the serotonin transporter (SERT). This compound was labeled with carbon-11 by methylation of the S-desmethyl precursor 10 with [(11)C]methyl iodide to obtain the potential positron emission tomography (PET) radioligand [(11)C]SMe-ADAM. The radiochemical yield was 27 +/- 5%, and the specific radioactivity was 26-40 GBq/micromol at the end of synthesis. Ex vivo and in vivo biodistribution experiments in rats demonstrated a rapid accumulation of the radiotracer in brain regions known to be rich in SERT, such as the thalamus/hypothalamus region (3.59 +/- 0.41%ID/g at 5 min after injection). The specific uptake reached a thalamus to cerebellum ratio of 6.74 +/- 0.95 at 60 min postinjection. The [(11)C]SMe-ADAM uptake in the thalamus was significantly decreased by pretreatment with fluoxetine to 38 +/- 11% of the control value. Furthermore, no metabolites of [(11)C]SMe-ADAM could be detected in the SERT-rich regions of the rat brain. It is concluded that [(11)C]SMe-ADAM may be a suitable PET ligand for SERT imaging in the living brain.

New records and range extensions of several species of native bees (Hymenoptera: Apoidea) from Mississippi

Science.gov (United States)

Griswold, Terry; Ikerd, Harold W; Orr, Michael Christopher

2018-01-01

Abstract Background The native bee fauna of Mississippi, USA has been historically poorly sampled, but is of particular relevance to determine range limits for species that occur in the southern United States. Currently published literature includes 184 species of bees that occur within the state of Mississippi. Additions to the list of native bees known for Mississippi are reported with notes on range, ecology and resources for identification. New information The geographic ranges of seven additional species are extended into the state of Mississippi: Andrena (Melandrena) obscuripennis Smith, 1853, Anthemurgus passiflorae Robertson, 1902, Dieunomia bolliana (Cockerell 1910), Diadasia (Diadasia) enavata (Cresson 1872), Peponapis crassidentata (Cockerell 1949), Triepeolus subnitens Cockerell and Timberlake, 1929 and Brachynomada nimia (Snelling and Rozen 1987). These records raise the total number of published species known from the state to 191. Anthemurgus and Brachynomada are also genera new to Mississippi. PMID:29853776

John Adams and CERN: Personal Recollections

CERN Document Server

Brianti, Giorgio

2013-01-01

By any standards, John Adams had a most remarkable career. He was involved in three important, emerging technologies, radar, particle accelerators and controlled fusion, and had an outstanding impact on the last two. Without a university education, he attained hierarchical positions of the highest level in prestigious national and international organizations. This article covers the CERN part of his career, by offering some personal insights into the different facets of his contributions to major accelerator projects, from the first strong-focusing synchrotron, the PS, to the SPS and its conversion to a proton–antiproton collider. In particular, it outlines his abilities as a leader of an international collaboration, which has served as an example for international initiatives in other disciplines.

First-trimester ADAM12 and PAPP-A as markers for intrauterine fetal growth restriction through their roles in the insulin-like growth factor system.

Science.gov (United States)

Cowans, Nicholas J; Spencer, Kevin

2007-03-01

PAPP-A is a marker used as part of the most effective method of screening for chromosomal anomalies in the first trimester. ADAM12 is a recently discovered pregnancy associated member of the ADAM (a multidomain glycoprotein metalloprotease) family. Recently, ADAM12 has been shown as a potential marker for early screening for chromosomal anomalies. Both PAPP-A and ADAM12 have been identified as proteases to insulin-like growth factor binding proteins. In this role, they may have a regulatory function in controlling the amount of free bioactive insulin-like growth factor (IGF). We therefore wish to examine if the levels of either of these proteases are related to various growth related adverse pregnancy outcomes. PAPP-A and ADAM12 were measured in a subset of samples collected at 11 to 14 weeks as part of an OSCAR clinic screening for chromosomal anomalies. Follow-up of pregnancies screened between September 1999 and August 2003 identified 1705 pregnancies with an outcome of intrauterine fetal demise on or after 24 weeks, preterm delivery at 24-34 weeks or 35-36 weeks, very low birthweight (4.5 kg), and birth weight below the 3rd or 5th or 10th centile for gestation. A series of 414 normal outcome pregnancies constituted the control group. Marker levels were adjusted for gestation and maternal weight and the log MoM of the markers were compared using t-test of unequal variance between the control group and the various adverse outcome groups. ADAM12 and PAPP-A concentrations were reduced in low for gestational age birth weights and in all births with weights below 2.5 kg. There was a linear relationship between the severity of the IUGR and the decrease in PAPP-A and ADAM12. In the larger babies, only ADAM12 was found to be significantly increased in babies above the 90th centile of weight for gestation. The results of our study are compatible with the proposed role of ADAM12 and PAPP-A in promoting growth and development by breaking down IGF binding proteins and

Customer Satisfaction Perceptions of Dislocated Workers Served by WIN Job Centers in the Mississippi Corridor Consortium

Science.gov (United States)

Washburn, Dava Michelle

2009-01-01

The purpose of this study was to determine the perceptions of satisfaction of dislocated workers served by WIN Job Centers in the Mississippi Corridor Consortium. Four WIN Job Centers participated in this study: Northeast Mississippi Community College WIN Job Center in Corinth, Northwest Mississippi Community College WIN Job Center in Oxford,…

US County-Level Trends in Mortality Rates for Major Causes of Death, 1980-2014.

Science.gov (United States)

Dwyer-Lindgren, Laura; Bertozzi-Villa, Amelia; Stubbs, Rebecca W; Morozoff, Chloe; Kutz, Michael J; Huynh, Chantal; Barber, Ryan M; Shackelford, Katya A; Mackenbach, Johan P; van Lenthe, Frank J; Flaxman, Abraham D; Naghavi, Mohsen; Mokdad, Ali H; Murray, Christopher J L

2016-12-13

County-level patterns in mortality rates by cause have not been systematically described but are potentially useful for public health officials, clinicians, and researchers seeking to improve health and reduce geographic disparities. To demonstrate the use of a novel method for county-level estimation and to estimate annual mortality rates by US county for 21 mutually exclusive causes of death from 1980 through 2014. Redistribution methods for garbage codes (implausible or insufficiently specific cause of death codes) and small area estimation methods (statistical methods for estimating rates in small subpopulations) were applied to death registration data from the National Vital Statistics System to estimate annual county-level mortality rates for 21 causes of death. These estimates were raked (scaled along multiple dimensions) to ensure consistency between causes and with existing national-level estimates. Geographic patterns in the age-standardized mortality rates in 2014 and in the change in the age-standardized mortality rates between 1980 and 2014 for the 10 highest-burden causes were determined. County of residence. Cause-specific age-standardized mortality rates. A total of 80 412 524 deaths were recorded from January 1, 1980, through December 31, 2014, in the United States. Of these, 19.4 million deaths were assigned garbage codes. Mortality rates were analyzed for 3110 counties or groups of counties. Large between-county disparities were evident for every cause, with the gap in age-standardized mortality rates between counties in the 90th and 10th percentiles varying from 14.0 deaths per 100 000 population (cirrhosis and chronic liver diseases) to 147.0 deaths per 100 000 population (cardiovascular diseases). Geographic regions with elevated mortality rates differed among causes: for example, cardiovascular disease mortality tended to be highest along the southern half of the Mississippi River, while mortality rates from self-harm and

78 FR 21537 - Drawbridge Operation Regulations; Upper Mississippi River, Rock Island, IL

Science.gov (United States)

2013-04-11

... Operation Regulations; Upper Mississippi River, Rock Island, IL AGENCY: Coast Guard, DHS. ACTION: Notice of... operating schedule that governs the Rock Island Railroad and Highway Drawbridge across the Upper Mississippi River, mile 482.9, at Rock Island, Illinois. The deviation is necessary to allow the Front Street 5K Run...

Reliability evaluation of I-123 ADAM SPECT imaging using SPM software and AAL ROI methods

Energy Technology Data Exchange (ETDEWEB)

Yang, Bang-Hung [Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan (China); Department of Nuclear Medicine, Taipei Veterans General Hospital, Taiwan (China); Tsai, Sung-Yi [Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan (China); Department of Imaging Medical, St.Martin De Porres Hospital, Chia-Yi, Taiwan (China); Wang, Shyh-Jen [Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan (China); Department of Nuclear Medicine, Taipei Veterans General Hospital, Taiwan (China); Su, Tung-Ping; Chou, Yuan-Hwa [Department of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan (China); Chen, Chia-Chieh [Institute of Nuclear Energy Research, Longtan, Taiwan (China); Chen, Jyh-Cheng, E-mail: jcchen@ym.edu.tw [Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei, Taiwan (China)

2011-08-21

The level of serotonin was regulated by serotonin transporter (SERT), which is a decisive protein in regulation of serotonin neurotransmission system. Many psychiatric disorders and therapies were also related to concentration of cerebral serotonin. I-123 ADAM was the novel radiopharmaceutical to image SERT in brain. The aim of this study was to measure reliability of SERT densities of healthy volunteers by automated anatomical labeling (AAL) method. Furthermore, we also used statistic parametric mapping (SPM) on a voxel by voxel analysis to find difference of cortex between test and retest of I-123 ADAM single photon emission computed tomography (SPECT) images. Twenty-one healthy volunteers were scanned twice with SPECT at 4 h after intravenous administration of 185 MBq of {sup 123}I-ADAM. The image matrix size was 128x128 and pixel size was 3.9 mm. All images were obtained through filtered back-projection (FBP) reconstruction algorithm. Region of interest (ROI) definition was performed based on the AAL brain template in PMOD version 2.95 software package. ROI demarcations were placed on midbrain, pons, striatum, and cerebellum. All images were spatially normalized to the SPECT MNI (Montreal Neurological Institute) templates supplied with SPM2. And each image was transformed into standard stereotactic space, which was matched to the Talairach and Tournoux atlas. Then differences across scans were statistically estimated on a voxel by voxel analysis using paired t-test (population main effect: 2 cond's, 1 scan/cond.), which was applied to compare concentration of SERT between the test and retest cerebral scans. The average of specific uptake ratio (SUR: target/cerebellum-1) of {sup 123}I-ADAM binding to SERT in midbrain was 1.78{+-}0.27, pons was 1.21{+-}0.53, and striatum was 0.79{+-}0.13. The cronbach's {alpha} of intra-class correlation coefficient (ICC) was 0.92. Besides, there was also no significant statistical finding in cerebral area using SPM2

Mehrkörpersimulation eines ebenen Koppelgetriebes mittels Matlab / ADAMS -Co-Simulation

OpenAIRE

Gollee, Christian; Troll, Clemens

2017-01-01

Mit Hilfe der Matlab/ADAMS-Co-Simulation wird ein ebenes Koppelgetriebe (5- Gelenk) untersucht und anschließend die Wirkpaarung mit einem Stückgut betrachtet. Dabei werden verschiedene Modellierungsstufen angewendet und die Simulationsergebnisse Messergebnissen vom Versuchsstand gegenübergestellt. Daneben wird die grundlegende Herangehensweise beim Einsatz dieser Simulationswerkzeuge erläutert.

ADAM: An Accident Diagnostic,Analysis and Management System - Applications to Severe Accident Simulation and Management

International Nuclear Information System (INIS)

Zavisca, M.J.; Khatib-Rahbar, M.; Esmaili, H.; Schulz, R.

2002-01-01

The Accident Diagnostic, Analysis and Management (ADAM) computer code has been developed as a tool for on-line applications to accident diagnostics, simulation, management and training. ADAM's severe accident simulation capabilities incorporate a balance of mechanistic, phenomenologically based models with simple parametric approaches for elements including (but not limited to) thermal hydraulics; heat transfer; fuel heatup, meltdown, and relocation; fission product release and transport; combustible gas generation and combustion; and core-concrete interaction. The overall model is defined by a relatively coarse spatial nodalization of the reactor coolant and containment systems and is advanced explicitly in time. The result is to enable much faster than real time (i.e., 100 to 1000 times faster than real time on a personal computer) applications to on-line investigations and/or accident management training. Other features of the simulation module include provision for activation of water injection, including the Engineered Safety Features, as well as other mechanisms for the assessment of accident management and recovery strategies and the evaluation of PSA success criteria. The accident diagnostics module of ADAM uses on-line access to selected plant parameters (as measured by plant sensors) to compute the thermodynamic state of the plant, and to predict various margins to safety (e.g., times to pressure vessel saturation and steam generator dryout). Rule-based logic is employed to classify the measured data as belonging to one of a number of likely scenarios based on symptoms, and a number of 'alarms' are generated to signal the state of the reactor and containment. This paper will address the features and limitations of ADAM with particular focus on accident simulation and management. (authors)

ADAMS-MATLAB Co-Simulation of A Serial Manipulator

Directory of Open Access Journals (Sweden)

Parthasarathy Tejaswin

2017-01-01

Full Text Available This paper presents the dynamic modelling and simulation of a now redundant robot, Mitsubishi RM-501, and proposes a general algorithm for experimental simulation in kinematics, dynamics and control analysis to any such robot. Through reverse engineering, a model as accurate as the real robot was developed in SolidWorks.The simulations of the same were performed in ADAMS (dynamicmodeling software offered by MSC Software Corpalong with MATLAB for motion studies and control dynamics. Finally, with a user-input path the accuracy and precision of the simulator was verified.

75 FR 81125 - Drawbridge Operation Regulation; Upper Mississippi River, Rock Island, IL

Science.gov (United States)

2010-12-27

... Operation Regulation; Upper Mississippi River, Rock Island, IL AGENCY: Coast Guard, DHS. ACTION: Notice of... the Upper Mississippi River, mile 481.4, at Rock Island, Illinois. The deviation is necessary to allow... Rock Island, Illinois to open on signal if at least 24 hours advance notice is given for 44 days from...

Adam Smith on public expenditure and taxation

Directory of Open Access Journals (Sweden)

Maurício C. Coutinho

2001-01-01

Full Text Available This paper presents Adam Smith’s view on taxation and public expenditure, by means of an almost literal reading of the Wealth of Nations famous passages on the "duties of the sovereign" and on the "maxims of taxation". Contrarily to the commonest usage of these passages, we will show that their core is the preoccupation with the public expenditure soaring and the defence of decentralisation. Furthermore and also contrarily to the existing interpretations we defend the non-existence of any contradiction between Smith’s income and price theory (and the incidence hypothesis, provided due attention is paid to the guiding role of the "maxims".

Add-on perampanel in Lance-Adams syndrome.

Science.gov (United States)

Steinhoff, Bernhard J; Bacher, Matthias; Kurth, Christoph; Staack, Anke M; Kornmeier, Reinhold

2016-01-01

Perampanel (PER) is the first-in-class selective, noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor antagonist that has been licensed and marketed as antiepileptic drug (AED) indicated for patients with partial-onset and primary generalized tonic-clonic seizures. A positive effect was reported in some patients with epileptic myoclonic jerks in idiopathic generalized epilepsy and in progressive myoclonic epilepsy. We treated a male patient with posthypoxic nonepileptic myoclonus (Lance-Adams syndrome) with add-on PER and achieved an almost complete cessation of jerks. This effect was reproducible and, therefore, we suggest that it might be worth trying PER in comparable cases.

Association of ADAM33 gene S1 and S2 transmembrane domain ...

African Journals Online (AJOL)

Background: Chronic obstructive pulmonary disease (COPD) is defined as a disease characterised by partially reversible and progressive airflow limitation associated with an abnormal inflammatory response of the lung with systemic manifestation. COPD is influenced by both environmental and genetic factors. ADAM33 (a ...

Deletion of admB gene encoding a fungal ADAM affects cell wall construction in Aspergillus oryzae.

Science.gov (United States)

Kobayashi, Takuji; Maeda, Hiroshi; Takeuchi, Michio; Yamagata, Youhei

2017-05-01

Mammals possess a unique signaling system based on the proteolytic mechanism of a disintegrin and metalloproteinases (ADAMs) on the cell surface. We found two genes encoding ADAMs in Aspergillus oryzae and named them admA and admB. We produced admA and admB deletion strains to elucidate their biological function and clarify whether fungal ADAMs play a similar role as in mammals. The ∆admA∆admB and ∆admB strains were sensitive to cell wall-perturbing agents, congo red, and calcofluor white. Moreover, the two strains showed significantly increased weights of total alkali-soluble fractions from the mycelial cell wall compared to the control strain. Furthermore, ∆admB showed MpkA phosphorylation at lower concentration of congo red stimulation than the control strain. However, the MpkA phosphorylation level was not different between ∆admB and the control strain without the stimulation. The results indicated that A. oryzae AdmB involved in the cell wall integrity without going through the MpkA pathway.

Electronic Cigarette Use among Mississippi Adults, 2015.

Science.gov (United States)

Mendy, Vincent L; Vargas, Rodolfo; Cannon-Smith, Gerri; Payton, Marinelle; Byambaa, Enkhmaa; Zhang, Lei

2017-01-01

Electronic cigarettes (e-cigarettes) are battery-powered devices that deliver nicotine in the form of aerosol. We identify differences and associations in e-cigarette use by sociodemographic characteristics and describe the reported reasons for initiating use among Mississippi adults. We used the 2015 Mississippi Behavioral Risk Factor Surveillance System, which collected information on e-cigarette use from 6,035 respondents. The prevalence of current e-cigarette use and having ever tried an e-cigarette was determined overall and by sociodemographic characteristics. Weighted prevalences and 95% confidence intervals were calculated, and prevalences for subgroups were compared using the X 2 tests and associations were assessed using logistic regression. In 2015, 4.7% of Mississippi adults currently used e-cigarettes, while 20.5% had ever tried an e-cigarette. The prevalence of current e-cigarette use was significantly higher for young adults, whites, men, individuals unable to work, those with income $35,000-$49,999, and current smokers compared to their counterparts. Similar results were observed for having ever tried an e-cigarette. E-cigarette use was associated with age, race, income, and smoking status. Most (71.2%) of current e-cigarette users and over half (52.1%) of those who have ever tried e-cigarettes reported that a main reason for trying or using e-cigarettes was "to cut down or quit smoking."

Electronic Cigarette Use among Mississippi Adults, 2015

Directory of Open Access Journals (Sweden)

Vincent L. Mendy

2017-01-01

Full Text Available Electronic cigarettes (e-cigarettes are battery-powered devices that deliver nicotine in the form of aerosol. We identify differences and associations in e-cigarette use by sociodemographic characteristics and describe the reported reasons for initiating use among Mississippi adults. We used the 2015 Mississippi Behavioral Risk Factor Surveillance System, which collected information on e-cigarette use from 6,035 respondents. The prevalence of current e-cigarette use and having ever tried an e-cigarette was determined overall and by sociodemographic characteristics. Weighted prevalences and 95% confidence intervals were calculated, and prevalences for subgroups were compared using the X2 tests and associations were assessed using logistic regression. In 2015, 4.7% of Mississippi adults currently used e-cigarettes, while 20.5% had ever tried an e-cigarette. The prevalence of current e-cigarette use was significantly higher for young adults, whites, men, individuals unable to work, those with income $35,000–$49,999, and current smokers compared to their counterparts. Similar results were observed for having ever tried an e-cigarette. E-cigarette use was associated with age, race, income, and smoking status. Most (71.2% of current e-cigarette users and over half (52.1% of those who have ever tried e-cigarettes reported that a main reason for trying or using e-cigarettes was “to cut down or quit smoking.”

ANALYSIS WITH MSC ADAMS OF A 5-FINGER AND 3-PHALANX /FINGER UNDER-ACTUATEDMECHANICAL HAND

Directory of Open Access Journals (Sweden)

Gheorghe POPESCU

2013-05-01

Full Text Available This paper studies the analysis with MSC ADAMS of a 5-fingered and 3-phalanx/finger underactuatedmechanical hand, designed by the author to work on industrial robots. Moreover, in order to increasegrasping safety in the automated handling process, the author has fitted each finger with a locking sequence inthe final phase of grasping. Thus, the mechanism of mechanical hand is considered to be a mechanical systemand is treated like a set of rigid bodies connected by mechanical linkages and elastic elements. To model andsimulate this mechanism with MSC ADAMS programme, the author covered the following stages: constructionof the model, testing-simulation, validation, finishing, parameterization, and optimization

Fishes in paleochannels of the Lower Mississippi River alluvial valley: A national treasure

Science.gov (United States)

Miranda, Leandro E.

2016-01-01

Fluvial geomorphology of the alluvial valley of the Lower Mississippi River reveals a fascinating history. A prominent occupant of the valley was the Ohio River, estimated to have flowed 25,000 years ago over western Tennessee and Mississippi to join the Mississippi River north of Baton Rouge, Louisiana, 750–800 km south of the present confluence. Over time, shifts in the Mississippi and Ohio rivers toward their contemporary positions have left a legacy of abandoned paleochannels supportive of unique fish assemblages. Relative to channels abandoned in the last 500 years, paleochannels exhibit harsher environmental conditions characteristic of hypereutrophic lakes and support tolerant fish assemblages. Considering their ecological, geological, and historical importance, coupled with their primordial scenery, the hundreds of paleochannels in the valley represent a national treasure. Altogether, these waterscapes are endangered by human activities and would benefit from the conservation attention afforded to our national parks and wildlife refuges.

75 FR 63086 - Great Mississippi Balloon Race and Fireworks Safety Zone; Lower Mississippi River, Mile Marker...

Science.gov (United States)

2010-10-14

... flying hot air balloons transiting across the Lower Mississippi River. Entry into this zone is prohibited... mariners from the safety hazards associated with a fireworks display and low flying hot air balloons... mariners from the safety hazards associated with a fireworks display and low flying hot air balloons...

ADAM-17: a novel therapeutic target for triple negative breast cancer.

LENUS (Irish Health Repository)

McGowan, P M

2013-02-01

Validated targeted therapy is currently unavailable for patients with invasive breast cancer negative for oestrogen receptors, progesterone receptors and HER2 [i.e., those with triple-negative (TN) disease]. ADAM-17 is a protease involved in the activations of several ligands that bind to and promotes intracellular signalling from the EGFR\\/HER family of receptors.

77 FR 26959 - Final Flood Elevation Determinations

Science.gov (United States)

2012-05-08

... River At the Mississippi County +335 Unincorporated Areas of boundary. Scott County. At the Alexander... 75110. Preston County, West Virginia, and Incorporated Areas Docket No.: FEMA-B-1166 Back Run At the...

The cysteine-rich domain of human ADAM 12 supports cell adhesion through syndecans and triggers signaling events that lead to beta1 integrin-dependent cell spreading

DEFF Research Database (Denmark)

Iba, K; Albrechtsen, R; Gilpin, B

2000-01-01

The ADAMs (a disintegrin and metalloprotease) family of proteins is involved in a variety of cellular interactions, including cell adhesion and ecto- domain shedding. Here we show that ADAM 12 binds to cell surface syndecans. Three forms of recombinant ADAM 12 were used in these experiments......-dependent manner attach to ADAM 12 via members of the syndecan family. After binding to syndecans, mesenchymal cells spread and form focal adhesions and actin stress fibers. Integrin beta1 was responsible for cell spreading because function-blocking monoclonal antibodies completely inhibited cell spreading......, and chondroblasts lacking beta1 integrin attached but did not spread. These data suggest that mesenchymal cells use syndecans as the initial receptor for the ADAM 12 cysteine-rich domain-mediated cell adhesion, and then the beta1 integrin to induce cell spreading. Interestingly, carcinoma cells attached but did...

Mississippi and Louisiana Estuarine Areas. Freshwater Diversion to Lake Pontchartrain Basin and Mississippi Sound. Feasibility Study. Volume 2. Technical Appendixes, A, B, C, D.

Science.gov (United States)

1984-04-01

Resource Inventory, March 1979. k/Over half of the reef is within Mobile Bay with an additional 870 acres occuring within Mississippi Sound. 2 / Deegan ...13.7 to 16.2 feet per year resulting In land loss rates of 1,670 to 2,093 acres per year prior to 1960 ( Craig et al., 1978). In Mississippi, land loss...contrlhuted to the increased width of canals. The annual increase in canal width has been estimated at 2 to 5 percent per year ( Craig et al., 197A). A

Drowning of the Mississippi Delta due to insufficient sediment supply and global sea-level rise

Science.gov (United States)

Blum, Michael D.; Roberts, Harry H.

2009-07-01

Over the past few centuries, 25% of the deltaic wetlands associated with the Mississippi Delta have been lost to the ocean. Plans to protect and restore the coast call for diversions of the Mississippi River, and its associated sediment, to sustain and build new land. However, the sediment load of the Mississippi River has been reduced by 50% through dam construction in the Mississippi Basin, which could affect the effectiveness of diversion plans. Here we calculate the amount of sediment stored on the delta plain for the past 12,000 years, and find that mean storage rates necessary to construct the flood plain and delta over this period exceed modern Mississippi River sediment loads. We estimate that, in the absence of sediment input, an additional 10,000-13,500km2 will be submerged by the year 2100 owing to subsidence and sea-level rise. Sustaining existing delta surface area would require 18-24billiontons of sediment, which is significantly more than can be drawn from the Mississippi River in its current state. We conclude that significant drowning is inevitable, even if sediment loads are restored, because sea level is now rising at least three times faster than during delta-plain construction.

Review of The use of bodies by Giorgio Agamben, translated by Adam Kotsko

OpenAIRE

Taylor, Rachael

2017-01-01

This article reviews Giorgio Agamben's ninth installment in his Homo Sacer series, The Use of Bodies by Giorgio Agamben, translated by Adam Kotsko. The review considers Agamben's political philosophy framing of the body with reference to existentialist philosophy.

The first reported ceratopsid dinosaur from eastern North America (Owl Creek Formation, Upper Cretaceous, Mississippi, USA).

Science.gov (United States)

Farke, Andrew A; Phillips, George E

2017-01-01

Ceratopsids ("horned dinosaurs") are known from western North America and Asia, a distribution reflecting an inferred subaerial link between the two landmasses during the Late Cretaceous. However, this clade was previously unknown from eastern North America, presumably due to limited outcrop of the appropriate age and depositional environment as well as the separation of eastern and western North America by the Western Interior Seaway during much of the Late Cretaceous. A dentary tooth from the Owl Creek Formation (late Maastrichtian) of Union County, Mississippi, represents the first reported occurrence of Ceratopsidae from eastern North America. This tooth shows a combination of features typical of Ceratopsidae, including a double root and a prominent, blade-like carina. Based on the age of the fossil, we hypothesize that it is consistent with a dispersal of ceratopsids into eastern North America during the very latest Cretaceous, presumably after the two halves of North America were reunited following the retreat of the Western Interior Seaway.

The first reported ceratopsid dinosaur from eastern North America (Owl Creek Formation, Upper Cretaceous, Mississippi, USA

Directory of Open Access Journals (Sweden)

Andrew A. Farke

2017-05-01

Full Text Available Ceratopsids (“horned dinosaurs” are known from western North America and Asia, a distribution reflecting an inferred subaerial link between the two landmasses during the Late Cretaceous. However, this clade was previously unknown from eastern North America, presumably due to limited outcrop of the appropriate age and depositional environment as well as the separation of eastern and western North America by the Western Interior Seaway during much of the Late Cretaceous. A dentary tooth from the Owl Creek Formation (late Maastrichtian of Union County, Mississippi, represents the first reported occurrence of Ceratopsidae from eastern North America. This tooth shows a combination of features typical of Ceratopsidae, including a double root and a prominent, blade-like carina. Based on the age of the fossil, we hypothesize that it is consistent with a dispersal of ceratopsids into eastern North America during the very latest Cretaceous, presumably after the two halves of North America were reunited following the retreat of the Western Interior Seaway.

Economic feasibility of producing sweet sorghum as an ethanol feedstock in the southeastern United States

International Nuclear Information System (INIS)

Linton, Joseph A.; Miller, J. Corey; Little, Randall D.; Petrolia, Daniel R.; Coble, Keith H.

2011-01-01

This study examines the feasibility of producing sweet sorghum (Sorghum bicolor (L.) Moench) as an ethanol feedstock in the southeastern United States through representative counties in Mississippi. We construct enterprise budgets along with estimates of transportation costs to estimate sweet sorghum producers' breakeven costs for producing and delivering sweet sorghum biomass. This breakeven cost for the sweet sorghum producer is used to estimate breakeven costs for the ethanol producer based on wholesale ethanol price, production costs, and transportation and marketing costs. Stochastic models are developed to estimate profits for sweet sorghum and competing crops in two representative counties in Mississippi, with sweet sorghum consistently yielding losses in both counties. -- Highlights: → We examine the economic feasibility of sweet sorghum as an ethanol feedstock. → We construct enterprise budgets along with estimates of transportation costs. → We estimate breakeven costs for producing and delivering sweet sorghum biomass. → Stochastic models determine profits for sweet sorghum in two Mississippi counties.

Adam Smith and the Educative Critique: A Response to My Commentators

Science.gov (United States)

Weinstein, Jack Russell

2015-01-01

This paper is both a response to the four reviewers in a special symposium on my book Adam Smith's Pluralism and a substantive discussion of philosophy of education. In it, I introduce what I call "the educative critique," a mode of analysis similar to Marxist, feminist, or postcolonial critiques, but focusing on the educative role of a…

Lack of ADAM2, CALR3 and SAGE1 Cancer/Testis Antigen Expression in Lung and Breast Cancer

DEFF Research Database (Denmark)

Maheswaran, Emeaga; Pedersen, Christina B; Ditzel, Henrik J

2015-01-01

and antigenic properties, but the expression patterns of most of the more than 200 identified cancer/testis antigens in various cancers remain largely uncharacterized. In this study, we investigated the expression of the cancer/testis antigens ADAM2, CALR3 and SAGE1 in lung and breast cancer, the two most...... frequent human cancers, with the purpose of providing novel therapeutic targets for these diseases. We used a set of previously uncharacterized antibodies against the cancer/testis antigens ADAM2, CALR3 and SAGE1 to investigate their expression in a large panel of normal tissues as well as breast and lung...... cancers. Staining for the well-characterized MAGE-A proteins was included for comparison. Immunohistochemical staining confirmed previous mRNA analysis demonstrating that ADAM2, CALR3 and SAGE1 proteins are confined to testis in normal individuals. Negative tissues included plancenta, which express many...

Unintended costs and consequences of school closures implemented in preparation for Hurricane Isaac in Harrison County School District, Mississippi, August-September 2012.

Directory of Open Access Journals (Sweden)

Yenlik Zheteyeva

Full Text Available School closures, while an effective measure against the spread of disease during a pandemic, may carry unintended social and economic consequences for students and families. We evaluated these costs and consequences following a 4-day school closure in Mississippi's Harrison County School District (HCSD.In a survey of all households with students enrolled in HCSD, we collected information on difficulties related to the school closure, including interruption of employment and pay, loss of access to subsidized school meals, and arrangement of alternative childcare. We analyzed this information in the context of certain demographic characteristics of the survey respondents and households, such as race, level of education, and income. We also estimated the average number of lost work days and documented the childcare alternatives chosen by households affected by the school closure.We received 2,229 (28.4% completed surveys from an estimated 7,851 households eligible to participate. About half (1,082 [48.5%] of the households experienced at least some difficulty during the closure, primarily in three areas: uncertainty about duration of the closure, lost income, and the effort of arranging alternate childcare. Adults working outside the home, particularly the major wage earner in the household, were more likely to suffer lost income while schools were closed, an effect mitigated by paid leave benefits. Difficulty arranging childcare was reported most frequently by respondents with lower levels of education and households with younger children. Beyond the top three concerns expressed by households in HCSD, the survey also shed light on the issue of food insecurity when subsidized school meals are not available. Reported by 17.9% of households participating in the subsidized school lunch program, difficulty providing meals during the closure was associated with higher numbers of dependent children, selection of "other" as the race of the household

Mississippi Business and Technology Framework, 2004

Science.gov (United States)

Mississippi Department of Education, 2004

2004-01-01

The primary purpose of the 2004 Mississippi Business and Technology Framework is to promote business and economic literacy, both successful domestic and international functioning, diverse practice of interpersonal, teamwork, and leadership skills, technology as a tool for managing information, and lifelong learning skills that foster flexible…

[{sup 11}C]SMe-ADAM, an imaging agent for the brain serotonin transporter: synthesis, pharmacological characterization and microPET studies in rats

Energy Technology Data Exchange (ETDEWEB)

Zessin, Joerg [Institut fuer Bioanorganische und Radiopharmazeutische Chemie, Forschungszentrum Rossendorf, 01314 Dresden (Germany)]. E-mail: j.zessin@fz-rossendorf.de; Deuther-Conrad, Winnie [Institut fuer Interdisziplinaere Isotopenforschung, 04318 Leipzig (Germany); Kretzschmar, Marion [Institut fuer Bioanorganische und Radiopharmazeutische Chemie, Forschungszentrum Rossendorf, 01314 Dresden (Germany); Wuest, Frank [Institut fuer Bioanorganische und Radiopharmazeutische Chemie, Forschungszentrum Rossendorf, 01314 Dresden (Germany); Pawelke, Beate [Institut fuer Bioanorganische und Radiopharmazeutische Chemie, Forschungszentrum Rossendorf, 01314 Dresden (Germany); Brust, Peter [Institut fuer Interdisziplinaere Isotopenforschung, 04318 Leipzig (Germany); Steinbach, Joerg [Institut fuer Interdisziplinaere Isotopenforschung, 04318 Leipzig (Germany); Bergmann, Ralf [Institut fuer Bioanorganische und Radiopharmazeutische Chemie, Forschungszentrum Rossendorf, 01314 Dresden (Germany)

2006-01-15

N,N-Dimethyl-2-(2-amino-4-methylthiophenylthio)benzylamine (S Me-Adam, 1) is a highly potent and selective inhibitor of the serotonin transporter (SPERT). This compound was labeled with carbon-11 by methylation of the S-desmethyl precursor 10 with [{sup 11}C]methyl iodide to obtain the potential positron emission tomography (PET) radioligand [{sup 11}C]S Me-Adam. The radiochemical yield was 27{+-}5%, and the specific radioactivity was 26-40 GBq/{mu}mol at the end of synthesis. Ex vivo and in vivo biodistribution experiments in rats demonstrated a rapid accumulation of the radiotracer in brain regions known to be rich in SPERT, such as the thalamus/hypothalamus region (3.59{+-}0.41%ID/g at 5 min after injection). The specific uptake reached a thalamus to cerebellum ratio of 6.74{+-}0.95 at 60 min postinjection. The [{sup 11}C]SMe-ADAM uptake in the thalamus was significantly decreased by pretreatment with fluoxetine to 38{+-}11% of the control value. Furthermore, no metabolites of [{sup 11}C]SMe-ADAM could be detected in the SERT-rich regions of the rat brain. It is concluded that [{sup 11}C]SMe-ADAM may be a suitable PET ligand for SERT imaging in the living brain.

Fractionation of rare earth elements in the Mississippi River estuary and river sediments

Science.gov (United States)

Adebayo, S. B.; Johannesson, K. H.

2017-12-01

This study presents the first set of data on the fractionation of rare earth elements (REE) in the mixing zone between the Mississippi River and the Gulf of Mexico, as well as the fractionation of REE in the operationally defined fractions of Mississippi River sediments. This subject is particularly important because the Mississippi river is one of the world's major rivers, and contributes a substantial amount of water and sediment to the ocean. Hence, it is a major source of trace elements to the oceans. The geochemistry of the REE in natural systems is principally important because of their unique chemical properties, which prompt their application as tracers of mass transportation in modern and paleo-ocean environments. Another important consideration is the growth in the demand and utilization of REE in the green energy and technology industries, which has the potential to bring about a change in the background levels of these trace elements in the environment. The results of this study show a heavy REE enrichment of both the Mississippi River water and the more saline waters of the mixing zone. Our data demonstrate that coagulation and removal of REE in the low salinity region of the estuary is more pronounced among the Light REE ( 35% for Nd) compared to the Heavy REE. Remarkably, our data also indicate that REE removal in the Mississippi River estuary is significantly less than that observed in other estuaries, including the Amazon River system. We propose that the high pH/alkalinity of the Mississippi River is responsible for the greater stability of REE in the Mississippi River estuary. The results of sequential extraction of river sediments reveal different Sm/Nd ratios for the various fractions, which we submit implies different 143Nd/144Nd ratios of the labile fractions of the sediments. The possible impact of such hypothesized different Nd isotope signatures of labile fractions of the river sediments on Gulf of Mexico seawater is under investigation.

Future reservoir management under climate change for the Mississippi River

International Nuclear Information System (INIS)

Asnaashari, Ahmad; Gharabaghi, Bahram; McBean, Edward A.; Kunjikutty, Sobhalatha; Lehman, Paul; Wade, Winston

2010-01-01

This paper is part of an ongoing research project designed to evaluate the effect of climate change on reservoir operation policies in the Mississippi Valley Conservation Authority. The study used the results from a first paper, including projected daily temperature and precipitation, for future streamflow calculation. This paper presented the development, calibration and validation of a rainfall-runoff NAM model for the Mississippi River watershed. The calibrated Mike11/NAM model was fed with predicted climatic data to generate long term future streamflow in the basin. Forecast flows were run in a Mike 11/HD model to estimate the corresponding lake levels. The storages and flows at Shabomeka Lake, Mazinaw Lake and Marble Lake were simulated. The results showed that climate change is likely to have implications for reservoir operations in the Mississippi River watershed, which will include changed water level regimes due to modifications in the projected future streamflow hydrograph to meet desired lake levels.

Adam Smith ja tema "nähtamatu käsi" / Arno Köörna

Index Scriptorium Estoniae

Köörna, Arno, 1926-2017

2004-01-01

Majandusliku ja sotsiaalse efektiivsuse optimaalsest vahekorrast. Inglise majandusteoreetiku, liberaalse turumajandusteooria klassikalise esindaja Adam Smithi (1723-1790) põhiteosest "Uurimus rahvaste rikkuse olemusest ja põhjustest". "Inimnäolise" kapitalismi võimalikkusest Eestis

Adam Smith y el derecho

Directory of Open Access Journals (Sweden)

Federico Escobar Córdoba

2004-12-01

Full Text Available Este artículo destaca el análisis jurídico en la obra de Adam Smith y su enriquecedor método de estudiar el derecho, particularmente en sus Lecciones de jurisprudencia. Esboza el contexto jurídico de las Lecciones e informa sobre su público original. Luego, describe la presencia del derecho romano en esa obra, deteniéndose en dos aspectos que los editores de la Edición Glasgow señalaron como errores o imprecisiones. El artículo analiza estos aspectos, ofrece posibles explicaciones alternativas que, a la vez, resaltan la complejidad del pensamiento jurídico de Smith. Finalmente, identifica tres niveles de análisis, empleados por Smith en las Lecciones, cuya interacción sería una contribución importante a la dogmática jurídica contemporánea.

Aerial gamma ray and magnetic survey: Mississippi and Florida airborne survey, Natchez quadrangle of, of Mississippi and Louisiana. Final report

International Nuclear Information System (INIS)

1980-07-01

The Natchez quadrangle covers a region within and adjacent to the Mississippi River flood plain in the northern Gulf Coastal Physiographic Province. The underlying Mesozoic and Cenozoic sediments of the Mississippi Embayment are extremely thick and contain many piercement structures. Exposed sediments consist largely of recent alluvium in the flood plain area, and Cenozoic sediments of marine and nonmarine origin in adjacent areas. A search of available literature revealed no known uranium deposits in the area. Eighty-three uranium anomalies were found, using the selection criteria set forth in Appendix A, and are discussed briefly. None were considered significant, and most appeared to be of cultural origin. Magnetic data suggests extremely deep sources, and some possible structural complexity in the source area

Thermodynamical analysis of an ADAM/EVA-process for electricity generation

International Nuclear Information System (INIS)

Knoche, K.F.; Tsatsaronis, G.; Loehrer, F.

1982-01-01

In this article, the so-called ADAM/EVA-process for long-range heat transport is presented as an alternative method of electricity generation, as being interesting from the purely thermodynamic point of view. For various variants of this process, extensive mass and energy balances are calculated. With the help of exact energy balances, the irreversibilities of the individual parts of the plant are determined and evaluated by comparison. (orig.) [de

Timing of Mississippi Valley-type mineralization: Relation to Appalachian orogenic events

Energy Technology Data Exchange (ETDEWEB)

Kesler, S.E.; van der Pluijm, B.A. (Univ. of Michigan, Ann Arbor (USA))

1990-11-01

Although Mississippi Valley-type deposits in Lower Ordovician carbonate rocks of the Appalachian orogen are commonly interpreted to have been precipitated by basinal brines, the timing of brine migration remains poorly known. Late Paleozoic K-Ar isotopic ages on authigenic K-feldspar, which is widespread in Appalachian carbonate rocks, as well as evidence of paleomagnetic overprints of similar age, have focused attention on the possibility that these Mississippi Valley-type deposits formed as a result of late Paleozoic deformation. Geologic and geochemical similarities among most of these deposits, from Georgia to Newfoundland, including unusually high sphalerite/galena ratios, isotopically heavy sulfur, and relatively nonradiogenic lead, suggest that they are coeval. Sphalerite sand that parallels host-rock layering in many of the deposits indicates that mineralization occurred before regional deformation. Although the late Paleozoic age of deformation in the southern Appalachians provides little constraint on the age of Mississippi Valley-type mineralization, deformation of these deposits in the Newfoundland Appalachians is early to middle Paleozoic in age. Thus, if Ordovician-hosted, Appalachian Mississippi Valley-type deposits are coeval, they must have formed by middle Paleozoic time and cannot be the product of a late Paleozoic fluid-expulsion event. This hypothesis has important implications for basin evolution, fluid events, and remagnetization in the Appalachians.

Economics of the coal industry east of the Mississippi, 1973-1982

Science.gov (United States)

Bhagwat, S.B.

1987-01-01

Government regulations on health, safety and environment have been poppular blamed for the declining productivity in U.S. coal mines since 1970. The stagnation in the coal industry east of the Mississippi is alleged to have been caused by this declining productivity and by the growth of cheaper and cleaner coal production west of the Mississippi. Economic evidence suggests, however, that productivity declines were more due to a relative lowering of labor costs in comparison with coal prices and due to work stoppages. The development of western coals fields was spurred by growth in local demand and had only a relatively small impact on coal production east of the Mississippi. Problems of the eastern coal industry are rooted mainly in slow economic growth in eastern U.S. which must be addressed in the long-term interests of the eastern coal industry. ?? 1987.

ADAM2 interactions with mouse eggs and cell lines expressing α4/α9 (ITGA4/ITGA9 integrins: implications for integrin-based adhesion and fertilization.

Directory of Open Access Journals (Sweden)

Ulyana V Desiderio

2010-10-01

Full Text Available Integrins are heterodimeric cell adhesion molecules, with 18 α (ITGA and eight β (ITGB subunits forming 24 heterodimers classified into five families. Certain integrins, especially the α(4/α(9 (ITGA4/ITGA9 family, interact with members of the ADAM (a disintegrin and metalloprotease family. ADAM2 is among the better characterized and also of interest because of its role in sperm function. Having shown that ITGA9 on mouse eggs participates in mouse sperm-egg interactions, we sought to characterize ITGA4/ITGA9-ADAM2 interactions.An anti-β(1/ITGB1 function-blocking antibody that reduces sperm-egg binding significantly inhibited ADAM2 binding to mouse eggs. Analysis of integrin subunit expression indicates that mouse eggs could express at least ten different integrins, five in the RGD-binding family, two in the laminin-binding family, two in the collagen-binding family, and ITGA9-ITGB1. Adhesion assays to characterize ADAM2 interactions with ITGA4/ITGA9 family members produced the surprising result that RPMI 8866 cell adhesion to ADAM2 was inhibited by an anti-ITGA9 antibody, noteworthy because ITGA9 has only been reported to dimerize with ITGB1, and RPMI 8866 cells lack detectable ITGB1. Antibody and siRNA studies demonstrate that ITGB7 is the β subunit contributing to RPMI 8866 adhesion to ADAM2.These data indicate that a novel integrin α-β combination, ITGA9-ITGB7 (α(9β(7, in RPMI 8866 cells functions as a binding partner for ADAM2. ITGA9 had previously only been reported to dimerize with ITGB1. Although ITGA9-ITGB7 is unlikely to be a widely expressed integrin and appears to be the result of "compensatory dimerization" occurring in the context of little/no ITGB1 expression, the data indicate that ITGA9-ITGB7 functions as an ADAM binding partner in certain cellular contexts, with implications for mammalian fertilization and integrin function.

A Summary of Fish Data in Six Reaches of The Upper Mississippi River System

National Research Council Canada - National Science Library

Gutreuter, Steve

1997-01-01

.... The six LTRMP study reaches are Pools 4 (excluding Lake Pepin), 8, 13, and 26 of the Upper Mississippi River, an unimpounded reach of the Mississippi River near Cape Girardeau, Missouri, and the La Grange Pool of the Illinois River...

33 CFR 110.194a - Mobile Bay, Ala., and Mississippi Sound, Miss.

Science.gov (United States)

2010-07-01

... Sound, Miss. 110.194a Section 110.194a Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF... Mississippi Sound, Miss. (a) The anchorage grounds. (1) The waters of lower Mobile Bay, near Cedar Point... south by latitude 30°20′00″, and on the west by longitude 88°06′00″. (2) The waters of Mississippi Sound...

Adam Smith on public expenditure and taxation

Directory of Open Access Journals (Sweden)

Maurício C. Coutinho

2009-05-01

Full Text Available This paper presents Adam Smith’s view on taxation and public expenditure, by means of an almost literal reading of the Wealth of Nations famous passages on the “duties of the sovereign” and on the “maxims of taxation”. Contrarily to the commonest usage of these passages, we will show that their core is the preoccupation with the public expenditure soaring and the defence of decentralisation. Furthermore – and also contrarily to the existing interpretations – we defend the non-existence of any contradiction between Smith’s income and price theory (and the incidence hypothesis, provided due attention is paid to the guiding role of the “maxims”.

Adam Smith and dependency.

Science.gov (United States)

Ozler, Sule

2012-06-01

The focus of this paper is the works and life of Adam Smith, who is widely recognized as the father and founder of contemporary economics. Latent content analysis is applied to his seminal text in economics, An Inquiry into the Nature and Causes of the Wealth of Nations (1776). The results reveal that Smith considers dependence on others a problem and sees the solution to this problem in impersonalized interdependence. In addition, his views on social dependency and personal dependency, reflected in his Lectures on Jurisprudence (1963) and The Theory of Moral Sentiments (1759), are analyzed. This analysis suggests a central tension between dependence and independence in Smith's writings. The personal dependency patterns he exhibited in his life, which also suggest a tension between dependence and independence, are identified through a reading of his biographies. Based on insights from psychoanalytic literature, this paper proposes that developing the ideas in the Wealth of Nations was part of Smith's creative solution to this tension. In particular, his solution to one individual's dependence on another was through a system of impersonalized interdependence. In other words, Smith defended against his personal dependence through his economic theorizing.

Adam Smith on population.

Science.gov (United States)

Spengler, J J

1970-11-01

Abstract Adam Smith dealt with questions of population mainly in his Wealth of Nations. His discussion falls roughly under five heads and reflects in considerable measure his image of the English economy. (1) A country's population capacity, given the average level of consumption, was conditioned by the stock of land, the skill with which it was cultivated, and the degree to which division of labour could be increased and thereby augment output for domestic use and sale in external markets. (2) Growth of population was essentially in response to growth of the demand for labour and served to increase division of labour. (3) The social mechanisms underlying elevation of the scale of living are touched upon, and in an optimistic spirit. (4) The distribution of a country's population responded to its progress in opulence, with the rate of this progress conditioned by the degree to which inappropriate (e.g. mercantilist) policies were avoided. (5) Smith dealt briefly with such matters as colonies, education, size of economy, environmental influences, and public policy, all of which he recognized as significant for the quantity and quality of a country's numbers.

78 FR 78717 - Reservoirs at Headwaters of the Mississippi River; Use and Administration

Science.gov (United States)

2013-12-27

... Headwaters of the Mississippi River; Use and Administration AGENCY: U.S. Army Corps of Engineers, DoD. ACTION... administration of the reservoirs at the headwaters of the Mississippi River by deleting from the Code of Federal... values that differ from those currently codified in the Code of Federal Regulations. Deleting all...

An Investigation of the Perception of Professional Development among Mississippi's Secondary Welding Teachers

Science.gov (United States)

Ferguson, Douglas Forrest

2012-01-01

This research study originated as a result of a paucity of information available regarding how secondary welding teachers in Mississippi perceive the value of professional development they have received within the previous two years. The purpose of this study was to examine the perceptions of Mississippi's secondary welding teachers regarding how…

Geospatial relationships of tree species damage caused by Hurricane Katrina in south Mississippi

Science.gov (United States)

Mark W. Garrigues; Zhaofei Fan; David L. Evans; Scott D. Roberts; William H. Cooke III

2012-01-01

Hurricane Katrina generated substantial impacts on the forests and biological resources of the affected area in Mississippi. This study seeks to use classification tree analysis (CTA) to determine which variables are significant in predicting hurricane damage (shear or windthrow) in the Southeast Mississippi Institute for Forest Inventory District. Logistic regressions...

An Assessment of Campus Police Departments across Mississippi's Public Community and Junior Colleges

Science.gov (United States)

Boggs, Brad D.

2012-01-01

The purpose of the study was to provide an assessment of campus police departments throughout the 15 public community and junior colleges in Mississippi. This research could provide Mississippi community and junior college administrators the opportunity to observe and appraise the overall safety of their respective campuses in comparison to safety…

Adam Smith et le “républicanisme”

Directory of Open Access Journals (Sweden)

Alexandra HYARD

2003-10-01

Full Text Available Je remercie Pierre Lurbe et Ann Thomson pour leurs remarques. Je tiens également à remercier Thierry Demals pour son aide précieuse. Néanmoins, je reste seule responsable des éventuelles erreurs contenues dans ce travail.Introduction Smith semble avoir toujours été en théorie un républicain, et il a sûrement eu le vrai esprit d’un républicain dans son amour de toute liberté rationnelle. (Rae 124 Par cette phrase, Rae nous livre son opinion sur une des questions relatives à Adam Smith (1723-1...

Community Resilience, Psychological Resilience, and Depressive Symptoms: An Examination of the Mississippi Gulf Coast 10 Years After Hurricane Katrina and 5 Years After the Deepwater Horizon Oil Spill.

Science.gov (United States)

Lee, Joohee; Blackmon, Bret J; Cochran, David M; Kar, Bandana; Rehner, Timothy A; Gunnell, Mauri Stubbs

2018-04-01

This study examined the role of community resilience and psychological resilience on depressive symptoms in areas on the Mississippi Gulf Coast that have experienced multiple disasters. Survey administration took place in the spring of 2015 to a spatially stratified, random sample of households. This analysis included a total of 294 subjects who lived in 1 of the 3 counties of the Mississippi Gulf Coast at the time of both Hurricane Katrina in 2005 and the Deepwater Horizon oil spill in 2010. The survey included the Communities Advancing Resilience Toolkit (CART) scale, the Connor-Davidson Resilience Scale (CD-RISC 10), and the Center for Epidemiologic Studies Depression Scale (CES-D). There was a significant inverse relationship between psychological resilience and depressive symptoms and a significant positive relationship between community resilience and psychological resilience. The results also revealed that community resilience was indirectly related to depressive symptoms through the mediating variable of psychological resilience. These findings highlight the importance of psychological resilience in long-term disaster recovery and imply that long-term recovery efforts should address factors associated with both psychological and community resilience to improve mental health outcomes. (Disaster Med Public Health Preparedness. 2018;12:241-248).

Level III Ecoregions of the Mississippi Alluvial Plain

Data.gov (United States)

U.S. Environmental Protection Agency — Ecoregions for the Mississippi Alluvial Plain were extracted from the seamless national shapefile. Ecoregions denote areas of general similarity in ecosystems and in...

Level IV Ecoregions of the Mississippi Alluvial Plain

Data.gov (United States)

U.S. Environmental Protection Agency — Ecoregions for the Mississippi Alluvial Plain were extracted from the seamless national shapefile. Ecoregions denote areas of general similarity in ecosystems and in...

An Austrian (mis)reads Adam Smith: a critique of Rothbard as intellectual historian

Czech Academy of Sciences Publication Activity Database

Matthews, P. H.; Ortmann, Andreas

2002-01-01

Roč. 14, č. 3 (2002), s. 379-392 ISSN 0953-8259 Institutional research plan: CEZ:AV0Z7085904 Keywords : Adam Smith * Rothbard Subject RIV: AH - Economics http://search.ebscohost.com/login.aspx?direct=true&db=bth&AN=6998203&site=ehost-live

Changing Course: navigating the future of the Lower Mississippi River

Science.gov (United States)

Cochran, S.

2016-02-01

Changing Course is a design competition to reimagine a more sustainable Lower Mississippi River Delta, bringing teams together from around the world to create innovative visions for one of America's greatest natural resources. Building off of Louisiana's Coastal Master Plan, and answering a key question from that plan, three winning teams (Baird & Associates, Moffatt & Nichol and Studio Misi-Ziibi) have generated designs for how the Mississippi River's water and sediment can be used to maximize rebuilding of delta wetlands while also continuing to meet the needs of navigation, flood protection, and coastal industries and communities. While each of the winning teams offered a different vision, all three identified the same key requirements as critical to sustaining the Mississippi River Delta today and into the future: Reconnecting the Mississippi River to its wetlands to help restore southeast Louisiana's first line of defense against powerful storms and rising sea levels. Planning for a more sustainable delta, including a gradual shift in population to create more protected and resilient communities. Protecting and maximizing the region's port and maritime activities, including a deeper more sustainable navigation channel upriver from Southwest Pass. Increasing economic opportunities in a future smaller delta through expanding shipping capacity, coastal restoration infrastructure, outdoor recreation and tourism and commercial fishing. This session will give a high level overview of the design competition process, results and common themes, similarities and differences in their designs, and how the ideas generated will inform coastal stakeholders and official government processes.

[Improvement and the mechanism of cardiac function by knockdown of ADAM10 in adriamycin-induced cardiomyopathy rats].

Science.gov (United States)

Li, Xiaoou; Xie, Lili; He, Bing; Huang, Wei

2018-01-01

Objective To study the role of a disintegrin and metalloproteinase10 (ADAM10) in shedding neural cadherin (N-cadherin) and develop an approach to interfere the process of ventricular remodeling in adriamycin-induced cardiomyopathy (ACM) rats. Methods In a rat model of ACM, the effects of intraperitoneal injection of the lentiviral RNAi vector of ADAM10 on the morphology of cardiomyocytes and contractile function were observed by HE staining and color Doppler echocardiography. The expressions of N-cadherin and C-terminal fragment 1 (CTF1) were detected by Western blotting and immunohistochemistry. Results In the in vivo experiment, a large amount of fluorescence was seen in the isolated primary cardiomyocytes, which indicated that the transfection in the rat model was successful. In the treatment group, the morphology of cardiomyocytes and function of the heart were evidently improved, N-cadherin protein expression was remarkably up-regulated and CTF1 protein was obviously down-regulated compared with the model group. Conclusion Knock-down of ADAM10 increases N-cadherin expression and decreases CTF1 expression, thus improves cardiac function in the rat model of ACM.

The Adam and Eve Robot Scientists for the Automated Discovery of Scientific Knowledge

Science.gov (United States)

King, Ross

A Robot Scientist is a physically implemented robotic system that applies techniques from artificial intelligence to execute cycles of automated scientific experimentation. A Robot Scientist can automatically execute cycles of hypothesis formation, selection of efficient experiments to discriminate between hypotheses, execution of experiments using laboratory automation equipment, and analysis of results. The motivation for developing Robot Scientists is to better understand science, and to make scientific research more efficient. The Robot Scientist `Adam' was the first machine to autonomously discover scientific knowledge: both form and experimentally confirm novel hypotheses. Adam worked in the domain of yeast functional genomics. The Robot Scientist `Eve' was originally developed to automate early-stage drug development, with specific application to neglected tropical disease such as malaria, African sleeping sickness, etc. We are now adapting Eve to work with on cancer. We are also teaching Eve to autonomously extract information from the scientific literature.

Low finding costs calculated in Mississippi's Tuscaloosa, Frio

International Nuclear Information System (INIS)

Dowty, S.G.; Moody, J.S.

1992-01-01

This paper reports on a recent study conducted by the Mississippi Office of Geology which examined oil and gas finding costs in southwestern Mississippi for the period from 1986 through 1990. The formations of interest were the Upper Cretaceous Lower Tuscaloosa formation and the Oligocene Frio formation. The model incorporated the following financial considerations for exploratory activity: seismic data acquisition, geologic expenses, leasing and legal fees, and drilling costs. Average drilling and completion costs were also assigned to the development wells. The finding cost formula divided the total exploration and development costs by the recoverable reserves. Reserves were multiplied by a 75% net revenue for the Tuscaloosa and 80% for the Frio leases to account for royalty interests and severance taxes. No field operating expenses were included

76 FR 48853 - FFP Project 70, LLC; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

Science.gov (United States)

2011-08-09

... (Corps) Mississippi Lock and Dam 19 on the Mississippi River, near Keokuk, Lee County, Iowa and Hancock... foundation against scour and undermining; (7) a 60-foot-wide, 75-foot- long new substation containing a step...

Predictability of surface currents and fronts off the Mississippi Delta

International Nuclear Information System (INIS)

Walker, N.D.; Rouse, L.J.; Wiseman, W.J.

2001-01-01

The dynamic coastal region of the lower Mississippi River was examined under varying conditions of wind, river discharge and circulation patterns of the Gulf of Mexico. Nearly 7,000 deep-sea merchant vessels enter the port complex each year and the area boasts the highest concentration of offshore drilling rigs, rendering the Mississippi delta and adjacent coastal areas vulnerable to risk from oil spills. Satellite imagery has been useful in tracking movements of the Mississippi river plume as recognizable turbidity and temperature fronts are formed where river waters encounter ambient shelf waters. Oil spill modelers often base their predictions of oil movement on the surface wind field and surface currents, but past studies have indicated that this can be overly simplistic in regions affected by river flow because river fronts have significant control over the movement of oil in opposition to prevailing winds. Frontal zones, such as those found where river waters meet oceanic waters, are characterized by strong convergence of surface flow. These frontal zones can provide large and efficient traps or natural booms for spilled oil. In an effort to facilitate cleanup operations, this study made use of the National Ocean and Atmospheric Administration (NOAA) AVHRR satellite imagery of temperature and reflectance to study front locations and their variability in space and time. The main objectives were to quantify surface temperature structure and locations of fronts throughout the year using satellite image data, to map the structure of the Mississippi sediment plume and to assess the forcing factors responsible for its variability over space and time. The final objective was to use in-situ measurements of surface currents together with satellite image data to better understand surface flow in this region of strong and variable currents. It was concluded that the main factors controlling circulation in the Mississippi River outflow region are river discharge and

75 FR 53193 - Safety Zone; Mississippi River, Mile 427.3 to 427.5

Science.gov (United States)

2010-08-31

... Zone; Mississippi River, Mile 427.3 to 427.5 AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone for all waters of the Upper Mississippi River, Mile 427.3 to 427.5, extending the entire width of the river. This safety zone is needed to...

75 FR 55272 - Safety Zone; Mississippi River, Mile 212.0 to 214.5

Science.gov (United States)

2010-09-10

...-AA00 Safety Zone; Mississippi River, Mile 212.0 to 214.5 AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone for waters of the Upper Mississippi River, Mile 212.0 to 214.5, extending West of Portage Island to the right descending bank of the...

77 FR 43354 - National Register of Historic Places; Notification of Pending Nominations and Related Actions

Science.gov (United States)

2012-07-24

...., Joplin, 12000473 St. Louis County North Taylor Avenue Historic District, (Kirkwood MPS) Roughly bounded by Manchester Rd., E. Adams, & N. Taylor Aves., Kirkwood, 12000474 NEW YORK Erie County American..., 12000482 OREGON Coos County Marshfield I.O.O.F. Cemetery, 750 Ingersoll Rd., Coos Bay, 12000483 Morrow...

Timber and forest birds

Science.gov (United States)

Brian Roy Lockhart

2009-01-01

Many years ago, I had an epiphany that I would like to share. Several students and I were installing research plots in the forests on Pittman Island, Issaquena County, Mississippi, an island adjacent to the Mississippi River, near the borders of Arkansas, Mississippi, and Louisiana. While eating lunch, we watched a bird, more specifically a prothonotary warbler (

Assessing Microplastic Loads in the Mississippi River and Its Major Tributaries

Science.gov (United States)

Hasenmueller, E. A.; Martin, K. M.; Conkle, J. L.; White, J. R.

2017-12-01

Plastic debris is ubiquitous in marine environments and can cause significant harm to aquatic life when organisms become entangled in the plastic or mistake it for food. Macroplastic debris (plastic >5 mm in diameter) has received significant attention from the public, government agencies, and the scientific community. However, the majority of plastics in aquatic environments are microplastics (plastic Administration (NOAA) Marine Debris Program, has quantified and characterized microplastics (i.e., size, shape, and resin type) at the surface and at depth along the mainstem of the Mississippi River, including near major cities such as St. Louis and New Orleans, as well as in some of the Mississippi River's major tributaries (i.e., the Missouri River, Ohio River, and Illinois River). Sampling is ongoing, but our datasets will allow us to characterize: 1) total microplastic concentrations and loads, 2) spatial and temporal trends in microplastic abundances, and 3) land-use effects on microplastic levels across the Mississippi River watershed. Our data will also provide estimates of the total discharge of microplastics from the Mississippi River to the Gulf of Mexico. These efforts will provide a baseline for future research relating to the fate and effects of microplastics in aquatic environments and can guide federal and local policy makers in creating and assessing mitigation strategies to improve water quality.

75 FR 41764 - Safety Zone; Mississippi River, Mile 840.0 to 839.8

Science.gov (United States)

2010-07-19

...-AA00 Safety Zone; Mississippi River, Mile 840.0 to 839.8 AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coat Guard is establishing a temporary safety zone for all waters of the Upper Mississippi River, Mile 840.0 to 839.8, extending the entire width of the river. This safety zone is needed to...

The status of safety in the public high school chemistry laboratories in Mississippi

Science.gov (United States)

Lacy, Sarah Louise Trotman

Since laboratory-based science courses have become an essential element of any science curriculum and are required by the Mississippi Department of Education for graduation, the chemistry laboratories in the public high schools in Mississippi must be safe. The purpose of this study was to determine: the safety characteristics of a high school chemistry laboratory; the perceived safety characteristics of the chemistry laboratories in public high schools in Mississippi; the basic safety knowledge of chemistry teachers in public high schools in Mississippi, where chemistry teachers in Mississippi gain knowledge about laboratory safety and instruction; if public high school chemistry laboratories in Mississippi adhere to recommended class size, laboratory floor space per student, safety education, safety equipment, and chemical storage; and the relationship between teacher knowledge of chemistry laboratory safety and the safety status of the laboratory in which they teach. The survey instrument was composed of three parts. Part I Teacher Knowledge consisted of 23 questions concerning high school chemistry laboratory safety. Part II Chemistry Laboratory Safety Information consisted of 40 items divided into four areas of interest concerning safety in high school chemistry laboratories. Part III Demographics consisted of 11 questions relating to teacher certification, experience, education, and safety training. The survey was mailed to a designated chemistry teacher in every public high school in Mississippi. The responses to Part I of the survey indicated that the majority of the teachers have a good understanding of knowledge about chemistry laboratory safety but need more instruction on the requirements for a safe high school chemistry laboratory. Less than 50% of the responding teachers thought they had received adequate preparation from their college classes to conduct a safe chemistry laboratory. According to the responses of the teachers, most of their high school

Rhetorical Studies: A Reassessment of Adam Smith's Lectures on Rhetoric and Belles Lettres.

Science.gov (United States)

Purcell, William M.

1986-01-01

Offers a dissenting interpretation of Adam Smith's Lectures on Rhetoric and Belles Lettres and a more conservative perspective on Smith's significance to the history of rhetorical theory. Views the lectures as an historical commentary on literature and rhetoric from the perspective of an eighteenth-century lecturer. (JD)

Biodistribution, toxicity and radiation dosimetry studies of the serotonin transporter radioligand 4-[{sup 18}F]-ADAM in rats and monkeys

Energy Technology Data Exchange (ETDEWEB)

Huang, Ya-Yao [Tri-Service General Hospital, PET Center, Department of Nuclear Medicine, Taipei (China); National Tsing Hua University, Department of Biomedical Engineering and Environmental Sciences, Hsinchu (China); Ma, Kuo-Hsing [National Defense Medical Center, Department of Biology and Anatomy, Taipei (China); Tseng, Ta-Wei; Chou, Ta-Kai; Huang, Wen-Sheng [Tri-Service General Hospital, PET Center, Department of Nuclear Medicine, Taipei (China); Ng, Hanna; Mirsalis, Jon C. [SRI International, Menlo Park, CA (United States); Fu, Ying-Kai [Institute of Nuclear Energy Research, Taoyuan (China); Chung Yuan Christian University, Department of Chemistry, Chung-Li (China); Chu, Tieh-Chi [National Tsing Hua University, Department of Biomedical Engineering and Environmental Sciences, Hsinchu (China); Yuanpei University, Department of Radiological Technology, Hsinchu (China); Shiue, Chyng-Yann [Tri-Service General Hospital, PET Center, Department of Nuclear Medicine, Taipei (China); University of Pennsylvania, Department of Radiology, Philadelphia, PA (United States)

2010-03-15

4-[{sup 18}F]-ADAM is a potent serotonin transport imaging agent. We studied its toxicity in rats and radiation dosimetry in monkeys before human studies are undertaken. Single and multiple-dosage toxicity studies were conducted in Sprague-Dawley rats. Male and female rats were injected intravenously with 4-F-ADAM as a single dose of 1,023.7 {mu}g/kg (1,000 times the human dose) or as five consecutive daily doses of 102.37 {mu}g/kg (100 times the human dose). PET/CT scans were performed in seven Formosa Rock monkeys (four males and three females) using a Siemens Biograph scanner. After injection of 4-[{sup 18}F]-ADAM (182{+-}8 MBq), a low dose CT scan and a series of eight whole-body PET scans were performed. Whole-body images were acquired in 3-D mode. Time-activity data of source organs were used to calculate the residence times and estimate the absorbed radiation dose using OLINDA/EXM software. In the rats neither the single dose nor the five daily doses of 4-F-ADAM produced overt adverse effects clinically. In the monkeys the radiation doses received by most organs ranged between 7.1 and 35.7 {mu}Gy/MBq, and the urinary bladder was considered to be the critical organ. The effective doses extrapolated to male and female adult humans were 17.4 and 21.8 {mu}Sv/MBq, respectively. Toxicity studies in Sprague-Dawley rats and radiation dosimetry studies in Formosa Rock monkeys suggested that 4-[{sup 18}F]-ADAM is safe for use in human PET imaging studies. (orig.)

Genetic variants of ADAM33 are associated with asthma susceptibility in the Punjabi population of Pakistan.

Science.gov (United States)

Sabar, Muhammad Farooq; Ghani, Muhammad Usman; Shahid, Mariam; Sumrin, Aleena; Ali, Amjad; Akram, Muhammad; Tariq, Muhammad Akram; Bano, Iqbal

2016-01-01

A disintegrin and metalloproteinase 33 (ADAM33) gene has been considered as an asthma susceptibility gene due to its possible role in airway remodeling, abnormal cell proliferation, and differentiation. Association of this gene with asthma has been reported in several genetic studies on various populations. The current study aims to evaluate the association of ADAM33 gene polymorphisms with the risk of asthma in the Punjabi population of Pakistan. A total of 101 asthma patients and 102 age-matched healthy controls from Lahore, a city in Punjab, were recruited. ADAM33 single nucleotide polymorphisms (SNPs) T + 1[rs2280089], T2[rs2280090], T1[rs2280091], ST + 5[rs597980], ST + 4[rs44707], S2[rs528557], Q - 1[rs612709], and F + 1[rs511898] were genotyped in both patients and controls using single base extension and capillary electrophoresis-based genetic analyzer. The basic allelic and genotypic model was analyzed for association of the SNPs with asthma using SHEsis software. Haploview software was used to calculate pairwise linkage disequilibrium (LD) among six of the genotyped SNPs. Of the 8 SNPs genotyped, only S2[rs528557] showed significant association with asthma (Allele p = 0.0189, Genotype p = 0.021). SNPs T + 1[rs2280089], T2[rs2280090], T1[rs2280091], ST + 4[rs44707], S2[rs528557], and Q - 1[rs612709] were found to be in moderate to strong LD. The significantly higher frequency of haplotype "AAGTCG" in healthy controls suggests a protective effect against asthma risk in the studied population (p = 0.0059). These findings suggest that genetic variants of ADAM33 gene may play important roles in asthma susceptibility in the Punjabi population of Pakistan.

Behavior of 226Ra in the Mississippi River mixing zone

Science.gov (United States)

Moore, Daniel G.; Scott, Martha R.

1986-12-01

The behavior of 226Ra in the Mississippi River mixing zone is strongly nonconservative and includes desorption similar to that reported for the Hudson, Pee Dee, and Amazon rivers. However, dissolved and desorbed 226Ra concentrations in the Mississippi are 2 to 5 times greater than in the other rivers at the same salinity. Radium concentrations vary inversely with the water discharge rate. The 226Ra desorption maximum occurs at a salinity of 5.0, much lower than the 18 to 28 salinity values for the maxima of the other three rivers. High concentrations of dissolved 226Ra (up to 82 dpm per 100 L) and the low salinity values for the desorption maximum in the Mississippi River result from three major factors. Suspended sediments include a large fraction of montmorillonite, which gives the sediment a high cation exchange capacity, 0.54 meq/g. The average suspended sediment load is large, about 510 mg/L, and contains 1.9 dpm/g desorbable 226Ra. The dissolved 226Ra river water end-member (9.6 dpm per 100 L) is higher than in surface seawater. The annual contribution of 226Ra to the ocean from the Mississippi River is 3.7 × 1014 dpm/yr, based on data from three cruises. Evidence of flux of 226Ra from estuarine and shelf sediments is common in vertical profile sampling of the deltaic waters but is not reflected in calculations made with an "apparent" river water Ra value extrapolated to zero salinity.

Hydraulic Geometry Analysis of the Lower Mississippi River

National Research Council Canada - National Science Library

Soar, Philip J; Thorne, Colin R; Harmar, Oliver P

2005-01-01

The hydraulic geometry of the Lower Mississippi River is primarily the product of the action of natural flows acting on the floodplain materials over centuries and millennia to form an alluvial forming a channel...

New records and range extensions of several species of native bees (Hymenoptera: Apoidea) from Mississippi

Science.gov (United States)

Currently published literature includes 184 species of bees that occur within the state of Mississippi. The geographic ranges of seven additional species are extended into the state of Mississippi: Andrena (Melandrena) obscuripennis Smith, 1853, Anthemurgus passiflorae Robertson, 1902, Dieunomia bol...

Water Resources Research Institute | Mississippi State University

Science.gov (United States)

Welcome The Mississippi Water Resources Research Institute provides a statewide center of expertise in water and associated land-use and serves as a repository of knowledge for use in education private interests in the conservation, development, and use of water resources; to provide training

Sequence-specific interaction between the disintegrin domain of mouse ADAM 3 and murine eggs: role of beta1 integrin-associated proteins CD9, CD81, and CD98.

Science.gov (United States)

Takahashi, Y; Bigler, D; Ito, Y; White, J M

2001-04-01

ADAM 3 is a sperm surface glycoprotein that has been implicated in sperm-egg adhesion. Because little is known about the adhesive activity of ADAMs, we investigated the interaction of ADAM 3 disintegrin domains, made in bacteria and in insect cells, with murine eggs. Both recombinant proteins inhibited sperm-egg binding and fusion with potencies similar to that which we recently reported for the ADAM 2 disintegrin domain. Alanine scanning mutagenesis revealed a critical importance for the glutamine at position 7 of the disintegrin loop. Fluorescent beads coated with the ADAM 3 disintegrin domain bound to the egg surface. Bead binding was inhibited by an authentic, but not by a scrambled, peptide analog of the disintegrin loop. Bead binding was also inhibited by the function-blocking anti-alpha6 monoclonal antibody (mAb) GoH3, but not by a nonfunction blocking anti-alpha6 mAb, or by mAbs against either the alphav or beta3 integrin subunits. We also present evidence that in addition to the tetraspanin CD9, two other beta1-integrin-associated proteins, the tetraspanin CD81 as well as the single pass transmembrane protein CD98 are expressed on murine eggs. Antibodies to CD9 and CD98 inhibited in vitro fertilization and binding of the ADAM 3 disintegrin domain. Our findings are discussed in terms of the involvement of multiple sperm ADAMs and multiple egg beta1 integrin-associated proteins in sperm-egg binding and fusion. We propose that an egg surface "tetraspan web" facilitates fertilization and that it may do so by fostering ADAM-integrin interactions.

Hurricane Katrina impacts on Mississippi forests

Science.gov (United States)

Sonja N. Oswalt; Christopher Oswalt; Jeffery Turner

2008-01-01

Hurricane Katrina triggered public interest and concern for forests in Mississippi that required rapid responses from the scientific community. A uniform systematic sample of 3,590 ground plots were established and measured in 687 days immediately after the impact of Hurricane Katrina on the Gulf Coast. The hurricane damaged an estimated 521 million trees with more...

ADAM10 and γ-secretase regulate sensory regeneration in the avian vestibular organs.

Science.gov (United States)

Warchol, Mark E; Stone, Jennifer; Barton, Matthew; Ku, Jeffrey; Veile, Rose; Daudet, Nicolas; Lovett, Michael

2017-08-01

The loss of sensory hair cells from the inner ear is a leading cause of hearing and balance disorders. The mammalian ear has a very limited ability to replace lost hair cells, but the inner ears of non-mammalian vertebrates can spontaneously regenerate hair cells after injury. Prior studies have shown that replacement hair cells are derived from epithelial supporting cells and that the differentiation of new hair cells is regulated by the Notch signaling pathway. The present study examined molecular influences on regeneration in the avian utricle, which has a particularly robust regenerative ability. Chicken utricles were placed in organotypic culture and hair cells were lesioned by application of the ototoxic antibiotic streptomycin. Cultures were then allowed to regenerate in vitro for seven days. Some specimens were treated with small molecule inhibitors of γ-secretase or ADAM10, proteases which are essential for transmission of Notch signaling. As expected, treatment with both inhibitors led to increased numbers of replacement hair cells. However, we also found that inhibition of both proteases resulted in increased regenerative proliferation. Subsequent experiments showed that inhibition of γ-secretase or ADAM10 could also trigger proliferation in undamaged utricles. To better understand these phenomena, we used RNA-Seq profiling to characterize changes in gene expression following γ-secretase inhibition. We observed expression patterns that were consistent with Notch pathway inhibition, but we also found that the utricular sensory epithelium contains numerous γ-secretase substrates that might regulate cell cycle entry and possibly supporting cell-to-hair cell conversion. Together, our data suggest multiple roles for γ-secretase and ADAM10 in vestibular hair cell regeneration. Copyright © 2017. Published by Elsevier Inc.

HYDROLOGY, CALHOUN COUNTY, MISSISSIPPI

Data.gov (United States)

Federal Emergency Management Agency, Department of Homeland Security — Hydrology data include spatial datasets and data tables necessary for documenting the hydrologic procedures for estimating flood discharges for a flood insurance...

HYDROLOGY, MONTGOMERY COUNTY, MISSISSIPPI

Data.gov (United States)

Federal Emergency Management Agency, Department of Homeland Security — Hydrology data include spatial datasets and data tables necessary for documenting the hydrologic procedures for estimating flood discharges for a flood insurance...

HYDROLOGY, NESHOBA COUNTY, MISSISSIPPI

Data.gov (United States)

Federal Emergency Management Agency, Department of Homeland Security — Hydrology data include spatial datasets and data tables necessary for documenting the hydrologic procedures for estimating flood discharges for a flood insurance...

HYDROLOGY, LEFLORE COUNTY, MISSISSIPPI

Data.gov (United States)

Federal Emergency Management Agency, Department of Homeland Security — Hydrology data include spatial datasets and data tables necessary for documenting the hydrologic procedures for estimating flood discharges for a flood insurance...

HYDROLOGY, NEWTON COUNTY, MISSISSIPPI

Data.gov (United States)

Federal Emergency Management Agency, Department of Homeland Security — Hydrology data include spatial datasets and data tables necessary for documenting the hydrologic procedures for estimating flood discharges for a flood insurance...

HYDROLOGY, LEAKE COUNTY, MISSISSIPPI

Data.gov (United States)

Federal Emergency Management Agency, Department of Homeland Security — Hydrology data include spatial datasets and data tables necessary for documenting the hydrologic procedures for estimating flood discharges for a flood insurance...

HYDROLOGY, WAYNE COUNTY, MISSISSIPPI

Data.gov (United States)

Federal Emergency Management Agency, Department of Homeland Security — Hydrology data include spatial datasets and data tables necessary for documenting the hydrologic procedures for estimating flood discharges for a flood insurance...

HYDROLOGY, SUNFLOWER COUNTY, MISSISSIPPI

Data.gov (United States)

Federal Emergency Management Agency, Department of Homeland Security — Hydrology data include spatial datasets and data tables necessary for documenting the hydrologic procedures for estimating flood discharges for a flood insurance...

HYDROLOGY, TIPPAH COUNTY, MISSISSIPPI

Data.gov (United States)

Federal Emergency Management Agency, Department of Homeland Security — Hydrology data include spatial datasets and data tables necessary for documenting the hydrologic procedures for estimating flood discharges for a flood insurance...

Childhood nutrition in the Mississippi Delta: challenges and opportunities.

Science.gov (United States)

Gray, Virginia B; Byrd, Sylvia H; Fountain, Brent J; Rader, Nicole E; Frugé, Andrew D

2016-12-01

Childhood obesity in the USA has more than tripled in the last three decades, and the prevalence is higher in the Mississippi Delta. Insight into the social, cultural and environmental factors that influence inequity can inform efforts to mediate health disparities. Focus groups (n = 12) among parents/guardians of elementary school children (n = 44) and teachers (n = 59) in the Mississippi Delta were used to investigate barriers and facilitators of healthy eating. Transcriptions were analyzed for themes. A strong preference for junk food among children and the pervasiveness of junk foods in schools and communities were cited as barriers to healthy eating. Potential facilitators of healthy eating included desire to avoid chronic disease, effort to limit junk food consumption and school support. Despite support for efforts to improve nutrition in the Delta, participants voiced a sense of inevitability related to children's consumption of unhealthy foods. This study suggests that parents and teachers express concern related to eating habits of children, yet they experience barriers to healthy eating which contribute to a sense of disempowerment. Improving health in the Mississippi Delta requires comprehensive strategies that offer its citizens a sense of agency. © The Author 2015. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

Salmonella rarely detected in Mississippi coastal waters and sediment.

Science.gov (United States)

Carr, M R; Wang, S Y; McLean, T I; Flood, C J; Ellender, R D

2010-12-01

Standards for the rapid detection of individual pathogens from environmental samples have not been developed, but in their absence, the use of molecular-based detection methods coupled with traditional microbiology techniques allows for rapid and accurate pathogen detection from environmental waters and sediment. The aim of this research was to combine the use of enrichment with PCR for detection of Salmonella in Mississippi coastal waters and sediment and observe if that presence correlated with levels of enterococci and climatological variables. Salmonella were primarily found in samples that underwent nutrient enrichment and were present more frequently in freshwater than marine waters. Salmonella were detected infrequently in marine and freshwater sediments. There was a significant positive correlation between the presence of detectable Salmonella and the average enterococcal count. An inverse relationship, however, was observed between the frequency of detection and the levels of salinity, turbidity and sunlight exposure. Results from this study indicated the presence of Salmonella in Mississippi coastal waters, and sediments are very low with significant differences between freshwater and marine environments. Using pathogenic and novel nonpathogenic molecular markers, Salmonella do not appear to be a significant pathogenic genus along the Mississippi Coast. © 2010 The Authors. Journal of Applied Microbiology © 2010 The Society for Applied Microbiology.

2015 NRCS-MDEQ Lidar: Southeast Mississippi QL2

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — This report contains a comprehensive outline of the Mississippi QL2 and Tupelo QL3 Lidar Processing task order for the United States Geological Survey (USGS). This...

Choctaws and Missionaries in Mississippi before 1830.

Science.gov (United States)

Kidwell, Clara Sue

1987-01-01

Examines history of Christian missionaries among the Choctaws in Mississippi area during 18th and 19th centuries. Describes agreements and conflicts between Indians, missionaries and federal government, especially regarding Indian education. Relationships apparently based on missionaries' desire to convert Indians and Choctaws' desire to learn…

77 FR 28255 - Safety Zone; Upper Mississippi River, Mile 183.0 to 183.5

Science.gov (United States)

2012-05-14

... on the Upper Mississippi River. Discussion of Rule The Coast Guard is establishing a temporary safety...-AA00 Safety Zone; Upper Mississippi River, Mile 183.0 to 183.5 AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone for all waters of the...

76 FR 30749 - Pennsylvania Disaster #PA-00038

Science.gov (United States)

2011-05-26

... SMALL BUSINESS ADMINISTRATION [Disaster Declaration 12594 and 12595] Pennsylvania Disaster PA... Administrative declaration of a disaster for the Commonwealth of Pennsylvania dated 05/18/2011. Incident... disaster: Primary Counties: Cumberland. Contiguous Counties: Pennsylvania: Adams, Dauphin, Franklin, Perry...

[Professor Adam Nowosławski (1925-2012)--founder of the Polish School of Immunopathology].

Science.gov (United States)

Madaliński, Kazimierz

2012-01-01

Professor dr med. Adam Nowosławski, has died at age of 87, on February 3, 2012, the founder of the Polish school of immunopathology, member of Polish Academy of Sciences and of Polish Academy of Art and Sciences. Professor was born on April 30, 1925 in Rzeszów (SE Poland). During the Second World War he took part in the anti-nazi resistance movement; he was the soldier of the 'Baszta' regiment of the Home Army. Subsequently, he was imprisoned in the Pawiak and concentration camps: Majdanek and Buchenwald. The medical studies he has completed at Warsaw Medical Academy between 1946-1951. The degree of doctor of medicine Prof. Adam Nowosławski has obtained in 1963, habilitation degree in the field of immunopathology--in 1966; the title of Professor he has obtained in 1980. His scientific achievements consist of 170 publications, including 101 original papers. His publications were quoted in several American books for students and physicians. Topics of his early papers concerned the immunopatogenesis ofPneumocystis carinii--induced pneumonia in premature babies, immunopatogenesis of rheumatoid arthritis, and the origin of rheumatoid factor. The enormous role in the field of hepatology played research on the virus of hepatitis B. These studies dealt with the discovery of HB core antigen which had the cellular localization different from HB surface antigen and with the parameters of the immune response to infection. Papers published on this topic were the mostly quoted in the literature and earned him national awards. The activity of Prof. Adam Nowosławski in the field of HIV/AIDS prevention was honored by the special prize of the Minister of Health. Professor was the honorary member of the two Societies: Polish Society of Pathologists and Polish Society of Hepatology. He was also the member of International Association for the Study of the Liver and International Academy of Pathology. Prof. Adam Nowosławski received the national medals: Polonia Restituta Crosses

78 FR 12365 - Tennessee Valley Authority; Notice of Receipt and Availability of Application for Renewal of...

Science.gov (United States)

2013-02-22

... 20852, or through the internet from the NRC's Agencywide Documents Access and Management System (ADAMS... Room is accessible from the NRC Web site at http://www.nrc.gov/reading-rm/adams.html . In addition, the... also be available to local residents near the site at the Chattanooga-Hamilton County Library...

78 FR 46258 - Safety Zone; Upper Mississippi River, Mile 662.8 to 663.9

Science.gov (United States)

2013-07-31

...-AA00 Safety Zone; Upper Mississippi River, Mile 662.8 to 663.9 AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary safety zone for all waters of the Upper Mississippi River, from mile 662.8 to 663.9, extending the entire width of the river. This safety...

Adam Smith and the objective use of economy as a way to obtain the fundamental right to liberty

Directory of Open Access Journals (Sweden)

Luiz Edmundo Celso Borba

2017-06-01

Full Text Available The contribution of Adam Smith for liberalism was great, but it is not limited to bringing an insane and unreasonable quest for freedom, as if all the costs were possible for such purpose. Adam Smith brings the birthplace of fundamental rights, to call for the need for recognition of individual liberties, although predicting problems for the exercise of such powers without limits. The idea of the text is to bring the initial outlook for the construction of fundamental rights in an individual prism and after its weighting in a mass spectrum as well as the subsequent discussion which should prevail.

The prevalence and correlates of the positive Androgen Deficiency in the Aging Male (ADAM questionnaire among psychiatric outpatients: a cross-sectional survey of 176 men in a general hospital in Taiwan

Directory of Open Access Journals (Sweden)

Lee CP

2015-01-01

Full Text Available Chin-Pang Lee,1,2 Yu Chen,2–4 Kun-Hao Jiang,2,4,5 Chun-Lin Chu,1,2,4 Shih-Chieh Hsu,1,2,4 Jiun-Liang Chen,2,4,5 Ching-Yen Chen1,2,41Department of Psychiatry, Chang Gung Memorial Hospital, Linkou, Taiwan; 2Men’s Health Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan; 3Department of Urology, Chang Gung Memorial Hospital, Linkou, Taiwan; 4School of Medicine, Chang Gung University, Taoyuan; 5Department of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Linkou, TaiwanIntroduction: The Androgen Deficiency in the Aging Male (ADAM questionnaire is widely used to screen for late-onset hypogonadism. The positive response to the ADAM questionnaire (positive ADAM has been associated with depression and poorer quality of life in a number of studies. It is unclear whether there is any value of the ADAM questionnaire in psychiatric populations. In this study, we aimed to determine the utility of the ADAM questionnaire in a convenient sample of male psychiatric outpatients.Methods: One hundred and seventy-six men (mean age: 54.3 years; standard deviation: 10.7 years; range: 40–80 years completed the ADAM questionnaire, the Hospital Anxiety and Depression Scale (HADS, and the Aging Males’ Symptoms (AMS scale. Anxiety was defined as a HADS anxiety subscore ≥8; depression as a HADS depression subscore ≥8; and moderate/severe impairment of health-related quality of life (HQoL as AMS ≥37. ADAM, anxiety, and depression was used to model the moderate/severe impairment of HQoL.Results: One hundred and sixty-four (93% men had positive ADAM. Positive ADAM was associated with a lower body mass index (P<0.05 and moderate/severe impairment of HQoL (P<0.001, but was not associated with anxiety or depression (P>0.05. Positive ADAM was associated with five symptoms of the AMS scale: “decline of one’s feeling of general well-being”, “depressive mood”, and three sexual symptoms. In regression analysis, positive ADAM was associated with

River Activism, “Levees-Only” and the Great Mississippi Flood of 1927

Directory of Open Access Journals (Sweden)

Ned Randolph

2018-02-01

Full Text Available This article investigates media coverage of 19th and early 20th century river activism and its effect on federal policy to control the Mississippi River. The U.S. Army Corps of Engineers’ “levees-only” policy—which joined disparate navigation and flood control interests—is largely blamed for the Great Flood of 1927, called the largest peacetime disaster in American history. River activists organized annual conventions, and later, professional lobbies organized media campaigns up and down the Mississippi River to sway public opinion and pressure Congress to fund flood control and river navigation projects. Annual river conventions drew thousands of delegates such as plantation owners, shippers, bankers, chambers of commerce, governors, congressmen, mayors and cabinet members with interests on the Mississippi River. Public pressure on Congress successfully captured millions of federal dollars to protect property, drain swamps for development, subsidize local levee districts and influence river policy.

77 FR 2254 - Endangered and Threatened Wildlife and Plants; Designation of Critical Habitat for Mississippi...

Science.gov (United States)

2012-01-17

... contact Stephen Ricks, Mississippi Ecological Services Field Office, at (601) 321-1122, as soon as...: Stephen Ricks, Field Supervisor, U.S. Fish and Wildlife Service, Mississippi Ecological Services Field... revised proposed rule as described below. Changes From the Revised Proposed Rule As the starting point for...

Deep-sea coral record of human impact on watershed quality in the Mississippi River Basin

NARCIS (Netherlands)

Prouty, N.G.; Roark, E.B.; Koenig, A.E.; Demopoulos, A.W.J.; Batista, F.C.; Kocar, B.D.; Selby, D.; McCarthy, M.D.; Mienis, F.

2014-01-01

One of the greatest drivers of historical nutrient and sediment transport into the Gulf of Mexico is the unprecedented scale and intensity of land use change in the Mississippi River Basin. These landscape changes are linked to enhanced fluxes of carbon and nitrogen pollution from the Mississippi

A Hydrograph-Based Sediment Availability Assessment: Implications for Mississippi River Sediment Diversion

Directory of Open Access Journals (Sweden)

Timothy Rosen

2014-03-01

Full Text Available The Mississippi River Delta Plain has undergone substantial land loss caused by subsidence, relative sea-level rise, and loss of connectivity to the Mississippi River. Many restoration projects rely on diversions from the Mississippi River, but uncertainty exists about the timing and the amount of actually available sediment. This study examined long-term (1980–2010 suspended sediment yield as affected by different hydrologic regimes to determine actual suspended sediment availability and how this may affect diversion management. A stage hydrograph-based approach was employed to quantify total suspended sediment load (SSL of the lower Mississippi River at Tarbert Landing during three river flow conditions: Peak Flow Stage (stage = 16.8 m, discharge >32,000 m3 s−1, High Flow Stage (stage = 14.6 m, discharge = 25,000–32,000 m3 s−1, and Intermediate Flow Stage (Stage = 12.1 m, discharge = 18,000–25,000 m3 s−1. Suspended sediment concentration (SSC and SSL were maximized during High Flow and Intermediate Flow Stages, accounting for approximately 50% of the total annual sediment yield, even though duration of the stages accounted for only one-third of a year. Peak Flow Stage had the highest discharge, but significantly lower SSC (p < 0.05, indicating that diversion of the river at this stage would be less effective for sediment capture. The lower Mississippi River showed significantly higher SSC (p < 0.0001 and SSL (p < 0.0001 during the rising than the receding limb. When the flood pulse was rising, Intermediate Flow and High Flow Stages showed greater SSC and SSL than Peak Flow Stage. Together, Intermediate Flow and High Flow Stages on the rising limb annually discharged 28 megatonnes over approximately 42 days, identifying this to be the best period for sediment capture and diversion.

An expanded model: flood-inundation maps for the Leaf River at Hattiesburg, Mississippi, 2013

Science.gov (United States)

Storm, John B.

2014-01-01

Digital flood-inundation maps for a 6.8-mile reach of the Leaf River at Hattiesburg, Mississippi (Miss.), were created by the U.S. Geological Survey (USGS) in cooperation with the City of Hattiesburg, City of Petal, Forrest County, Mississippi Emergency Management Agency, Mississippi Department of Homeland Security, and the Emergency Management District. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/, depict estimates of the areal extent and depth of flooding corresponding to selected water levels (stages) at the USGS streamgage at Leaf River at Hattiesburg, Miss. (station no. 02473000). Current conditions for estimating near-real-time areas of inundation by use of USGS streamgage information may be obtained on the Internet at http://waterdata.usgs.gov/. In addition, the information has been provided to the National Weather Service (NWS) for incorporation into their Advanced Hydrologic Prediction Service (AHPS) flood warning system (http://water.weather.gov/ahps/). The NWS forecasts flood hydrographs at many places that are often colocated with USGS streamgages. NWS-forecasted peak-stage information may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. In this study, flood profiles were computed for the stream reach by means of a one-dimensional step-backwater model. The model was calibrated by using the most current stage-discharge relations at the Leaf River at Hattiesburg, Miss. streamgage (02473000) and documented high-water marks from recent and historical floods. The hydraulic model was then used to determine 13 water-surface profiles for flood stages at 1.0-foot intervals referenced to the streamgage datum and ranging from bankfull to approximately the highest recorded water level at the streamgage. The simulated water-surface profiles were then combined with a geographic information system (GIS

Tracing historical trends of Hg in the Mississippi River using Hg concentrations and Hg isotopic compositions in a lake sediment core, Lake Whittington, Mississippi, USA

Science.gov (United States)

Gray, John E.; Van Metre, Peter C.; Pribil, Michael J.; Horowitz, Arthur J.

2015-01-01

Concentrations and isotopic compositions of mercury (Hg) in a sediment core collected from Lake Whittington, an oxbow lake on the Lower Mississippi River, were used to evaluate historical sources of Hg in the Mississippi River basin. Sediment Hg concentrations in the Lake Whittington core have a large 10-15 y peak centered on the 1960s, with a maximum enrichment factor relative to Hg in the core of 4.8 in 1966. The Hg concentration profile indicates a different Hg source history than seen in most historical reconstructions of Hg loading. The timing of the peak is consistent with large releases of Hg from Oak Ridge National Laboratory (ORNL), primarily in the late 1950s and 1960s. Mercury was used in a lithiumisotope separation process by ORNL and an estimated 128Mg (megagrams) of Hgwas discharged to a local stream that flows into the Tennessee River and, eventually, the Mississippi River. Mass balance analyses of Hg concentrations and isotopic compositions in the Lake Whittington core fit a binary mixing model with a Hg-rich upstream source contributing about 70% of the Hg to Lake Whittington at the height of the Hg peak in 1966. This upstream Hg source is isotopically similar to Hg isotope compositions of stream sediment collected downstream near ORNL. It is estimated that about one-half of the Hg released from the ORNL potentially reached the LowerMississippi River basin in the 1960s, suggesting considerable downstream transport of Hg. It is also possible that upstream urban and industrial sources contributed some proportion of Hg to Lake Whittington in the 1960s and 1970s.

Rival ecologies of global commerce: Adam Smith and the natural historians.

Science.gov (United States)

Jonsson, Fredrik Albritton

2010-01-01

This essay explores how the defense of global commerce pioneered in the Enlightenment was tied to the improvement of the natural order. Two rival ecologies, one made by natural historians and the other developed by Adam Smith and his liberal successors, vied for intellectual precedence as well as for practical application in the metropole and the colonies. Together they constitute the beginnings of an ongoing quarrel over the environmental foundation of capitalism.

77 FR 39393 - Special Local Regulation; Upper Mississippi River, Mile 842.0 to 840.0

Science.gov (United States)

2012-07-03

... is establishing a temporary special local regulation for all waters of the Upper Mississippi River... 1625-AA00 Special Local Regulation; Upper Mississippi River, Mile 842.0 to 840.0 AGENCY: Coast Guard, DHS. ACTION: Temporary final rule. SUMMARY: The Coast Guard is establishing a temporary special local...

A Review of Cash Management Policies, Procedures and Practices of Mississippi's Institutions of Higher Learning.

Science.gov (United States)

Mississippi State Legislature, Jackson. Performance Evaluation and Expenditure Review Committee.

This report to the Mississippi Legislature presents the findings of a review of the cash management policies, procedures, and practices of the State Board of Trustees of Institutions of Higher Learning (IHL). The methodology involved review of: applicable Mississippi statutes; standards promulgated by the National Association of College and…

The many ways of feeding ADAM

International Nuclear Information System (INIS)

Ambrosch-Draxl, C.

2008-01-01

Full text: The research group is dedicated to computational materials science, mostly applying and developing methods based on density functional theory (DFT). Methodological developments concern excited state properties but also the improvement of ground state calculations, both through the implementation of new functionals and the combination of DFT with manybody perturbation theory. Such a procedure may be driven by materials under investigation, which range from conventional inorganic semiconductors via organic semiconductors to complex nanostructures, and from simple metals via metal alloys to superconductors. Some of the most recent research projects are embedded into research networks, such as the NFN interface controlled and functionalized organic films, or the ERA Nanoscience Project NaPhoD - Nano-Hybrids for photonic devices. Another line of research is dedicated to metal alloys and complex interfaces, carried out within the framework of the COMET program recently established in Leoben. All this work requires high-performance computing power, which was realized in the computer cluster ADAM installed at the Montanuniversitaet. (author)

Case study: adams mine landfill proposal

International Nuclear Information System (INIS)

Oates, L.

2003-01-01

I have been asked to comment on 'how to address social concerns' in my capacity as the project manager for the City of Toronto's Toronto Integrated Solid Waste Resource Management (TIRM) Process, which was initiated in 1997 and concluded in the Fall of 2000. Inherent in this request is the goal of learning from a non-nuclear procurement process in order to offer insights for those working in the field on the short- and long-term management of nuclear waste. In particular, I have been asked to comment on the learning experience from the proposed engagement of the Adams Mine Landfill that became the focus of an intense four-day debate before Toronto's City Council and was propelled into international news linked to Toronto's Olympic bid. I would like to extend my thanks to Natural Resources Canada for their support of my participation in the NEA Conference. The opinions in this paper are those of the author and not those of the City of Toronto. (author)

Repeatability indices for the Adams D-15 test for colour-normal and colour-defective adults.

Science.gov (United States)

Hovis, Jeffery K; Ramaswamy, Shankaran; Anderson, Matthew

2004-07-01

The Adams desaturated D-15 test was administered to individuals with normal colour vision or with congenital red-green colour vision defects to establish the repeatability of the test. One hundred subjects with normal colour vision and 64 subjects with defective colour vision participated in the study. Results were analysed from two different sessions to determine the repeatability of the test for different pass/fail criteria. The test was scored using both visual inspection of the score sheet and the modified Colour Difference Vector analysis (CDV) program. For both subject groups, the repeatability was lowest when a perfect arrangement was required for a pass and improved as more errors were allowed. The improvement in repeatability was greatest as the failure criterion changed from 'any mistake' to 'more than two crossings'. The kappa coefficient for the reliability of the defect classification was 0.38 for visual inspection and 0.59 for the CDV analysis. All the protans who failed the test at both sessions were classified correctly. Approximately 98 per cent of the colour-normals and 82 per cent of the colour-defectives would have the same pass/fail outcome on the Adams D-15 test conducted several days apart when the failure criterion was either one or more or two or more crossings. Individuals who make less than four crossings on the Adams D-15 should repeat the test to ensure confidence in the pass/fail result.

Groundwater availability of the Mississippi embayment

Science.gov (United States)

Clark, Brian R.; Hart, Rheannon M.; Gurdak, Jason J.

2011-01-01

Groundwater is an important resource for agricultural and municipal uses in the Mississippi embayment. Arkansas ranks first in the Nation for rice and third for cotton production, with both crops dependent on groundwater as a major source of irrigation requirements. Multiple municipalities rely on the groundwater resources to provide water for industrial and public use, which includes the city of Memphis, Tennessee. The demand for the groundwater resource has resulted in groundwater availability issues in the Mississippi embayment including: (1) declining groundwater levels of 50 feet or more in the Mississippi River Valley alluvial aquifer in parts of eastern Arkansas from agricultural pumping, (2) declining groundwater levels of over 360 feet over the last 90 years in the confined middle Claiborne aquifer in southern Arkansas and northern Louisiana from municipal pumping, and (3) litigation between the State of Mississippi and a Memphis water utility over water rights in the middle Claiborne aquifer. To provide information to stakeholders addressing the groundwater-availability issues, the U.S. Geological Survey Groundwater Resources Program supported a detailed assessment of groundwater availability through the Mississippi Embayment Regional Aquifer Study (MERAS). This assessment included (1) an evaluation of how these resources have changed over time through the use of groundwater budgets, (2) development of a numerical modeling tool to assess system responses to stresses from future human uses and climate trends, and (3) application of statistical tools to evaluate the importance of individual observations within a groundwater-monitoring network. An estimated 12 million acre-feet per year (11 billion gallons per day) of groundwater was pumped in 2005 from aquifers in the Mississippi embayment. Irrigation constitutes the largest groundwater use, accounting for approximately 10 million acre-feet per year (9 billion gallons per day) in 2000 from the Mississippi

Source, habitat and nutrient enrichment effects on decomposition of detritus in Lower Mississippi River Basin bayous

Science.gov (United States)

Potential differences in storage and processing of detritus in agricultural landscapes may alter freshwater ecosystem function. We compared decomposition rates of maize (Zea mays) and willow oak (Quercus phellos) from three bayous located within the Lower Mississippi River Basin of NW Mississippi, ...

The futility of utility: how market dynamics marginalize Adam Smith

Science.gov (United States)

McCauley, Joseph L.

2000-10-01

Economic theorizing is based on the postulated, nonempiric notion of utility. Economists assume that prices, dynamics, and market equilibria are supposed to be derived from utility. The results are supposed to represent mathematically the stabilizing action of Adam Smith's invisible hand. In deterministic excess demand dynamics I show the following. A utility function generally does not exist mathematically due to nonintegrable dynamics when production/investment are accounted for, resolving Mirowski's thesis. Price as a function of demand does not exist mathematically either. All equilibria are unstable. I then explain how deterministic chaos can be distinguished from random noise at short times. In the generalization to liquid markets and finance theory described by stochastic excess demand dynamics, I also show the following. Market price distributions cannot be rescaled to describe price movements as ‘equilibrium’ fluctuations about a systematic drift in price. Utility maximization does not describe equilibrium. Maximization of the Gibbs entropy of the observed price distribution of an asset would describe equilibrium, if equilibrium could be achieved, but equilibrium does not describe real, liquid markets (stocks, bonds, foreign exchange). There are three inconsistent definitions of equilibrium used in economics and finance, only one of which is correct. Prices in unregulated free markets are unstable against both noise and rising or falling expectations: Adam Smith's stabilizing invisible hand does not exist, either in mathematical models of liquid market data, or in real market data.

ADAM10/17-Dependent Release of Soluble c-Met Correlates with Hepatocellular Damage

Czech Academy of Sciences Publication Activity Database

Chalupský, Karel; Kanchev, Ivan; Žbodáková, Olga; Buryová, Halka; Jiroušková, Markéta; Kořínek, Vladimír; Gregor, Martin; Sedláček, Radislav

2013-01-01

Roč. 59, č. 2 (2013), s. 76-78 ISSN 0015-5500 R&D Projects: GA ČR GAP305/10/2143; GA ČR GAP303/10/2044; GA AV ČR IAA500520812 Institutional support: RVO:68378050 Keywords : c-Met * HGF * shedding * ADAM metalloproteinase * liver Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 0.778, year: 2013

Overweight, Obesity, and Extreme Obesity Among Mississippi Adults, 2001?2010 and 2011?2015

OpenAIRE

Mendy, Vincent L.; Vargas, Rodolfo; Cannon-Smith, Gerri; Payton, Marinelle

2017-01-01

Introduction In 2015, about 1.5 million adults in Mississippi were overweight or obese. Obesity is associated with increased risk for diabetes and cardiovascular problems. We examined trends in the prevalence of overweight, obesity, and extreme obesity from 2001 through 2010 and 2011 through 2015. Methods We used data from the Mississippi Behavioral Risk Factor Surveillance System to analyze trends in the prevalence of overweight, obesity, and extreme obesity among adults from 2001 through 20...

78 FR 7427 - Council of the City of New Orleans; Mississippi Public Service Commission; Arkansas Public...

Science.gov (United States)

2013-02-01

... DEPARTMENT OF ENERGY Federal Energy Regulatory Commission [Docket No. EL13-43-000] Council of the City of New Orleans; Mississippi Public Service Commission; Arkansas Public Service Commission; Notice..., the Council of the City of New Orleans, the Mississippi Public Service Commission and the Arkansas...

The ADAM and EVE project: Heat transfer at ambient temperature

International Nuclear Information System (INIS)

Boltendahl, U.; Harth, R.

1980-01-01

In the nuclear research plant at Juelich a new heating system is at present being developed as part of the Nuclear Long-distance Heating Project. Helium is heated up in a high-temperature reactor. The heat chemically converts a gas mixture in a reformer plant (EVE). The gases 'charged' with energy can be transported through tubes over any distance required at ambient temperatures. In a methanisation plant (ADAM) the gases react with one another, releasing the energy in the form of heat which can be used for heating air or water. (orig.) [de

Sequence-Specific Interaction between the Disintegrin Domain of Mouse ADAM 3 and Murine Eggs: Role of β1 Integrin-associated Proteins CD9, CD81, and CD98

Science.gov (United States)

Takahashi, Yuji; Bigler, Dora; Ito, Yasuhiko; White, Judith M.

2001-01-01

ADAM 3 is a sperm surface glycoprotein that has been implicated in sperm-egg adhesion. Because little is known about the adhesive activity of ADAMs, we investigated the interaction of ADAM 3 disintegrin domains, made in bacteria and in insect cells, with murine eggs. Both recombinant proteins inhibited sperm-egg binding and fusion with potencies similar to that which we recently reported for the ADAM 2 disintegrin domain. Alanine scanning mutagenesis revealed a critical importance for the glutamine at position 7 of the disintegrin loop. Fluorescent beads coated with the ADAM 3 disintegrin domain bound to the egg surface. Bead binding was inhibited by an authentic, but not by a scrambled, peptide analog of the disintegrin loop. Bead binding was also inhibited by the function-blocking anti-α6 monoclonal antibody (mAb) GoH3, but not by a nonfunction blocking anti-α6 mAb, or by mAbs against either the αv or β3 integrin subunits. We also present evidence that in addition to the tetraspanin CD9, two other β1-integrin-associated proteins, the tetraspanin CD81 as well as the single pass transmembrane protein CD98 are expressed on murine eggs. Antibodies to CD9 and CD98 inhibited in vitro fertilization and binding of the ADAM 3 disintegrin domain. Our findings are discussed in terms of the involvement of multiple sperm ADAMs and multiple egg β1 integrin-associated proteins in sperm-egg binding and fusion. We propose that an egg surface “tetraspan web” facilitates fertilization and that it may do so by fostering ADAM–integrin interactions. PMID:11294888

Two Single-Nucleotide Polymorphisms in ADAM12 Gene Are Associated with Early and Late Radiographic Knee Osteoarthritis in Estonian Population

Directory of Open Access Journals (Sweden)

Irina Kerna

2013-01-01

Full Text Available Objectives. To investigate associations of selected single-nucleotide polymorphisms (SNPs in ADAM12 gene with radiographic knee osteoarthritis (rKOA in Estonian population. Methods. The rs3740199, rs1871054, rs1278279, and rs1044122 SNPs in ADAM12 gene were genotyped in 438 subjects (303 women from population-based cohort, aged 32 to 57 (mean 45.4. The rKOA features were evaluated in the tibiofemoral joint (TFJ and patellofemoral joint. Results. The early rKOA was found in 51.4% of investigated subjects (72% women and 12.3% of participants (63% women had advanced stage of diseases. The A allele of synonymous SNP rs1044122 was associated with early rKOA in TFJ, predominantly with the presence of osteophytes in females (OR 1.57; 95% CI 1.08–2.29, . The C allele of intron polymorphism rs1871054 carried risk for advanced rKOA, mostly to osteophyte formation in TFJ in males (OR 3.03; 95% CI 1.11–7.53, . Also the CCAA haplotype of ADAM12 was associated with osteophytosis, again mostly in TFJ in males (. For rs3740199 and rs1278279, no statistically significant associations were observed. Conclusion.  ADAM12 gene variants are related to rKOA risk during the early and late stages of diseases. The genetic risk seems to be predominantly associated with the appearance of osteophytes—a marker of bone remodelling and neochondrogenesis.

Outlook for Mississippi Alluvial Valley forests: a subregional report from the Southern Forest Futures Project

Science.gov (United States)

Emile S. Gardiner

2015-01-01

The Mississippi Alluvial Valley, which can be broadly subdivided into the Holocene Deposits section and the Deltaic Plain section, is a 24.9-million-acre area generally approximating the alluvial floodplain and delta of the lower Mississippi River. Its robust agricultural economy is maintained by a largely rural population, and recreational resources draw high...

Mississippi and Louisiana Estuarine Areas. Freshwater Diversion to Lake Pontchartrain Basin and Mississippi Sound. Feasibility Study. Volume 1. Main Report.

Science.gov (United States)

1984-04-01

states that the 27edernl Covernment will not iarticipatc in the development of zec ~eation >:-.cilities unless they are on 1:-nda that would be acquired by...President, Biloxi, MS Mr. Peter C. Everett, Mississippi ’Research and Development Center, Jackson, MS Mr. David Etzold, Hniversity of Southern

In vivo targeting of ADAM9 gene expression using lentivirus-delivered shRNA suppresses prostate cancer growth by regulating REG4 dependent cell cycle progression.

Directory of Open Access Journals (Sweden)

Che-Ming Liu

Full Text Available Cancer cells respond to stress by activating a variety of survival signaling pathways. A disintegrin and metalloproteinase (ADAM 9 is upregulated during cancer progression and hormone therapy, functioning in part through an increase in reactive oxygen species. Here, we present in vitro and in vivo evidence that therapeutic targeting of ADAM9 gene expression by lentivirus-delivered small hairpin RNA (shRNA significantly inhibited proliferation of human prostate cancer cell lines and blocked tumor growth in a murine model of prostate cancer bone metastasis. Cell cycle studies confirmed an increase in the G1-phase and decrease in the S-phase population of cancer cells under starvation stress conditions, which correlated with elevated intracellular superoxide levels. Microarray data showed significantly decreased levels of regenerating islet-derived family member 4 (REG4 expression in prostate cancer cells with knockdown of ADAM9 gene expression. This REG4 downregulation also resulted in induction of expression of p21(Cip1/WAF1, which negatively regulates cyclin D1 and blocks the G1/S transition. Our data reveal a novel molecular mechanism of ADAM9 in the regulation of prostate cancer cell proliferation, and suggests a combined modality of ADAM9 shRNA gene therapy and cytotoxic agents for hormone refractory and bone metastatic prostate cancer.

Near-surface stratigraphy and morphology, Mississippi Inner Shelf, northern Gulf of Mexico

Science.gov (United States)

Flocks, James G.; Kindinger, Jack; Kelso, Kyle W.; Bernier, Julie C.; DeWitt, Nancy T.; FitzHarris, Michael

2015-01-01

Over the past decade, the Mississippi Barrier Islands have been the focus of a comprehensive geologic investigation by the U.S. Geological Survey (USGS), in collaboration with the U.S. Army Corps of Engineers (USACE) and the National Park Service (NPS). The islands (Dauphin, Petite Bois, Horn, East Ship, West Ship, and Cat) are part of the Gulf Islands National Seashore (GUIS), and provide a diverse ecological habitat, protect the mainland from storm waves, and help maintain estuarine conditions within Mississippi Sound. Over the past century, the islands have been in a state of decline with respect to elevation and land-area loss. In 2005, the islands were severely impacted by Hurricane Katrina, which inundated them with a storm surge of 8 meters, causing severe shoreface erosion and widening breaches in Dauphin, West Ship, and Cat Islands. To evaluate the impact and fate of the islands, understanding their evolution and resiliency became a priority for the USGS under the Northern Gulf of Mexico Ecosystem Change and Hazard Susceptibility Project. The project formed the basis for collaboration with the USACE Mississippi Coastal Improvement Project, which is intended to restore portions of coastal Mississippi and GUIS affected by storm impact. Since then, many studies have contributed to our understanding of the islands’ morphology and nearshore stratigraphy. This report expands upon the nearshore component to provide a stratigraphic and morphologic assessment offshore of Petit Bois Island.

How To Survive in Postindustrial Environments: Adam Smith's Advice for Today's Colleges and Universities.

Science.gov (United States)

Ortmann, Andreas

1997-01-01

Adam Smith's discussion of the payment modes of teachers and resulting consequences for the quality of teaching and process of curricular innovation are reviewed through the conceptual lens of modern agency theory. Smith's analysis of higher education in his day (eighteenth century) sheds light on faculty incentive and assessment problems that…

Lance-Adams syndrome: A special case of a mother.

Science.gov (United States)

Nigam, Gaurav Bhaskar; Babu, Sachin Suresh; Peter, C Sudhir; Peter, C Shobhna

2016-09-01

Predicting the neurological outcome in survivors of cardiorespiratory arrest is difficult. A distinction has been made between acute and chronic posthypoxic myoclonus, called myoclonic status epilepticus and Lance-Adams syndrome (LAS), respectively, with the acute condition carrying a bad prognosis. Here, we report a case of a 37-year-old female who developed seizures after a successful cardiopulmonary resuscitation. The available literature on such cases is very rare and has generally mentioned a poor outcome. However, our patient was successfully managed and showed clinical features of LAS. Thus, making an early diagnosis and proper management of hypoxic brain insults is positively related to improving the patient's functional outcome.

Liver protective effect of ursodeoxycholic acid includes regulation of ADAM17 activity

Czech Academy of Sciences Publication Activity Database

Buryová, Halka; Chalupský, Karel; Žbodáková, Olga; Kanchev, Ivan; Jiroušková, Markéta; Gregor, Martin; Sedláček, Radislav

2013-01-01

Roč. 13, 30.10.2013 (2013), s. 155-155 ISSN 1471-230X R&D Projects: GA ČR GAP305/10/2143; GA ČR GAP303/10/2044; GA AV ČR IAA500520812; GA MŠk ED1.1.00/02.0109 Institutional support: RVO:68378050 Keywords : ursodeoxycholic acid * ADAM17 * shedding * cholestasis * liver Subject RIV: EB - Genetics ; Molecular Biology Impact factor: 2.113, year: 2013

Breastfeeding Practices and Barriers to Implementing the Ten Steps to Successful Breastfeeding in Mississippi Hospitals.

Science.gov (United States)

Alakaam, Amir; Lemacks, Jennifer; Yadrick, Kathleen; Connell, Carol; Choi, Hwanseok Winston; Newman, Ray G

2018-05-01

Mississippi has the lowest rates of breastfeeding in the United States at 6 and 12 months. There is growing evidence that the rates and duration of infant breastfeeding improve after hospitals implement the Ten Steps to Successful Breastfeeding; moreover, the Ten Steps approach is considered the standard model for evaluation of breastfeeding practices in birthplaces. Research aim: This study aimed to examine the implementation level of the Ten Steps and identify barriers to implementing the Ten Steps in Mississippi hospitals. A cross-sectional self-report survey was used to answer the research aim. Nurse managers of the birthing and maternity units of all 43 Mississippi hospitals that provided birthing and maternity care were recruited. A response rate of 72% ( N = 31) was obtained. Implementation of the Ten Steps in these hospitals was categorized as low, partial, moderate, or high. The researcher classified implementation in 29% of hospitals as moderate and in 71% as partial. The hospital level of implementation was significantly positively associated with the hospital delivery rate along with the hospital cesarean section rate per year. The main barriers for the implementation process of the Ten Steps reported were resistance to new policies, limited financial and human resources, and lack of support from national and state governments. Breastfeeding practices in Mississippi hospitals need to be improved. New policies need to be established in Mississippi to encourage hospitals to adopt the Ten Steps policies and practice in the maternity and birthing units.

The MAFLA (Mississippi, Alabama, Florida) Study, Grain Size Analyses

Data.gov (United States)

National Oceanic and Atmospheric Administration, Department of Commerce — The MAFLA (Mississippi, Alabama, Florida) Study was funded by NOAA as part of the Outer Continental Shelf Program. Dr. L.J. Doyle produced grain size analyses in the...

Inland Waters - Mississippi River Centerline - Headwaters to Gulf Coast

Data.gov (United States)

Army Corps of Engineers, Department of the Army, Department of Defense — Mississippi River centerline data derived from USACE navigation sailing line (recommended track) data and on-screen digitized in areas of no data. Data set extends...

Occurrence of phosphorus in groundwater and surface water of northwestern Mississippi

Science.gov (United States)

Welch, Heather L.; Kingsbury, James A.; Coupe, Richard H.

2010-01-01

Previous localized studies of groundwater samples from the Mississippi River Valley alluvial (MRVA) aquifer have demonstrated that dissolved phosphorus concentrations in the aquifer are much higher than the national background concentration of 0.03 milligram per liter (mg/L) found in 400 shallow wells across the country. Forty-six wells screened in the MRVA aquifer in northwestern Mississippi were sampled from June to October 2010 to characterize the occurrence of phosphorus in the aquifer, as well as the factors that might contribute to high dissolved phosphorus concentrations in groundwater. Dissolved phosphorus concentrations ranged from 0.12 to 1.2 mg/L with a median concentration of 0.62 mg/L. The predominant subunit of the MRVA aquifer in northwestern Mississippi is the Holocene alluvium in which median dissolved phosphorus concentrations were higher than the Pleistocene valley trains deposits subunit. Highest phosphorus concentrations occurred in water from wells located along the Mississippi River. A general association between elevated phosphorus concentrations and dissolved iron concentrations suggests that reducing conditions that mobilize iron in the MRVA aquifer also might facilitate transport of phosphorus. Using baseflow separation to estimate the contribution of baseflow to total streamflow, the estimated contribution to the total phosphorus load associated with baseflow at the Tensas River at Tendal, LA, and at the Bogue Phalia near Leland, MS, was 23 percent and 8 percent, respectively. This analysis indicates that elevated concentrations of dissolved phosphorus in the MRVA aquifer could be a possible source of phosphorus to streams during baseflow conditions. However, the fate of phosphorus in groundwater discharge and irrigation return flow to streams is not well understood.