WorldWideScience

Sample records for ada regulatory locus

  1. The genetic and regulatory architecture of ERBB3-type 1 diabetes susceptibility locus

    DEFF Research Database (Denmark)

    Kaur, Simranjeet; Mirza, Aashiq H.; Brorsson, Caroline Anna

    2016-01-01

    -producing INS-1E cells and the genetic and regulatory architecture of the ERBB3 locus to provide insights to how rs2292239 may confer disease susceptibility. rs2292239 strongly correlated with residual β-cell function and metabolic control in children with T1D. ERBB3 locus associated lncRNA (NONHSAG011351...

  2. Construction of an integrative regulatory element and variation map of the murine Tst locus.

    Science.gov (United States)

    Beltram, Jasmina; Morton, Nicholas M; Kunej, Tanja; Horvat, Simon

    2016-06-11

    Given the abundance of new genomic projects and gene annotations, researchers trying to pinpoint causal genetic variants are faced with a challenging task of how to efficiently integrate all current genomic information. The objective of the study was to develop an approach to integrate various genomic annotations for a recently positionally-cloned Tst gene (Thiosulfate Sulfur Transferase, synonym Rhodanese) responsible for the Fob3b2 QTL effect on leanness and improved metabolic parameters. The second aim was to identify and prioritize Tst genetic variants that may be causal for the phenotypic effects. A bioinformatics approach was developed to integrate existing knowledge of regulatory elements of the Tst gene. The entire Tst locus along with flanking segments was sequenced between our unique polygenic mouse Fat and Lean strains that were generated by divergent selection on adiposity for over 60 generations. The bioinformatics-generated regulatory element map of the Tst locus was then combined with genetic variants between the Fat and Lean mice and with comparative analyses of polymorphisms across 17 mouse strains in order to prioritise likely causal polymorphisms. Two candidate regulatory variants were identified, one overlapping an evolutionary constrained Tst intronic element and the other residing in the seed region of a predicted 3'UTR miRNA binding site. This study developed a map of regulatory elements for the Tst locus in mice and identified candidate genetic variants with increased causal likelihood. This map provides a basis for experimental validation and functional analyses of this novel candidate leanness and antidiabetic gene. Our methodological approach is of general utility for analyzing regulation of loci that have limited annotations and experimental evidence and for identifying candidate causal regulatory genetic variants in post-GWAS or post-QTL- cloning studies.

  3. The diabetes type 1 locus Idd6 modulates activity of CD4+CD25+ regulatory T-cells.

    Science.gov (United States)

    Rogner, Ute Christine; Lepault, Françoise; Gagnerault, Marie-Claude; Vallois, David; Morin, Joëlle; Avner, Philip; Boitard, Christian

    2006-01-01

    The genetic locus Idd6 confers susceptibility to the spontaneous development of type 1 diabetes in the NOD mouse. Our studies on disease resistance of the congenic mouse strain NOD.C3H 6.VIII showed that Idd6 influences T-cell activities in the peripheral immune system and suggest that a major mechanism by which the Idd6 locus modifies diabetes development is via modulation of regulatory T-cell activities. Our transfer experiments using total splenocytes and purified T-cells demonstrated that the locus specifically controls the efficiency of disease protection mediated by the regulatory CD4(+)CD25(+) T-cell subset. Our data also implicate the Idd6 locus in controlling the balance between infiltrating lymphocytes and antigen-presenting cells within the pancreatic islet.

  4. Genomic approaches uncover increasing complexities in the regulatory landscape at the human SCL (TAL1 locus.

    Directory of Open Access Journals (Sweden)

    Pawandeep Dhami

    2010-02-01

    Full Text Available The SCL (TAL1 transcription factor is a critical regulator of haematopoiesis and its expression is tightly controlled by multiple cis-acting regulatory elements. To elaborate further the DNA elements which control its regulation, we used genomic tiling microarrays covering 256 kb of the human SCL locus to perform a concerted analysis of chromatin structure and binding of regulatory proteins in human haematopoietic cell lines. This approach allowed us to characterise further or redefine known human SCL regulatory elements and led to the identification of six novel elements with putative regulatory function both up and downstream of the SCL gene. They bind a number of haematopoietic transcription factors (GATA1, E2A LMO2, SCL, LDB1, CTCF or components of the transcriptional machinery and are associated with relevant histone modifications, accessible chromatin and low nucleosomal density. Functional characterisation shows that these novel elements are able to enhance or repress SCL promoter activity, have endogenous promoter function or enhancer-blocking insulator function. Our analysis opens up several areas for further investigation and adds new layers of complexity to our understanding of the regulation of SCL expression.

  5. Epigenetic regulation of individual modules of the immunoglobulin heavy chain locus 3’ regulatory region (3’ RR

    Directory of Open Access Journals (Sweden)

    Barbara K Birshtein

    2014-04-01

    Full Text Available The Igh locus undergoes an amazing array of DNA rearrangements and modifications during B cell development. During early stages, the variable region gene is constructed from constituent variable (V, diversity (D and joining (J segments (VDJ joining. B cells that successfully express an antibody can be activated, leading to somatic hypermutation (SHM focused on the variable region, and class switch recombination (CSR, which substitutes downstream constant region genes for the originally used Cμ constant region gene. Many investigators, ourselves included, have sought to understand how these processes specifically target the Igh locus and avoid other loci and potential deleterious consequences of malignant transformation. Our laboratory has concentrated on a complex regulatory region (RR that is located downstream of Cα, the most 3’ of the Igh constant region genes. The ~40 kb 3’ RR, which is predicted to serve as a downstream major regulator of the Igh locus, contains two distinct segments: an ~28 kb region of four enhancers and an adjacent ~12 kb region containing multiple CTCF and Pax5 binding sites. Analysis of targeted mutations in mice by a number of investigators has concluded that the entire 3’ RR enhancer region is essential for SHM and CSR (but not for VDJ joining and for high levels of expression of multiple isotypes. The CTCF/Pax5 binding region is a candidate for influencing VDJ joining early in B cell development and serving as a potential insulator of the Igh locus. Components of the 3’ RR are subject to a variety of epigenetic changes during B cell development, i.e., DNAse I hypersensitivity, histone modifications and DNA methylation, in association with transcription factor binding. We propose that these changes provide a foundation by which regulatory elements in modules of the 3’ RR function by interacting with each other and with target sequences of the Igh locus.

  6. The tissue-specific extinguisher locus TSE1 encodes a regulatory subunit of cAMP-dependent protein kinase.

    Science.gov (United States)

    Boshart, M; Weih, F; Nichols, M; Schütz, G

    1991-09-06

    The tissue-specific extinguisher locus TSE1, a dominant negative regulator of transcription in somatic cell hybrids, acts via a cAMP response element (CRE) to repress activity of a hepatocyte-specific enhancer. Guided by the antagonism between TSE1 and cAMP-mediated signal transduction, we identified the regulatory subunit RI alpha of protein kinase A (PKA) as the product of the TSE1 locus. The evidence derives from concordant expression of RI alpha mRNA and TSE1 genetic activity, high resolution mapping of the RI alpha gene and TSE1 on human chromosome 17, and the ability of a transfected RI alpha cDNA to generate a phenocopy of TSE1-mediated extinction. The mechanism of TSE1/RI alpha-mediated extinction involves repression of basal PKA activity, reduced phosphorylation of CREB at Ser-133, and a corresponding reduction of in vivo protein binding at the target CRE.

  7. Regulatory cross-talk in the double par locus of plasmid pB171

    DEFF Research Database (Denmark)

    Ringgaard, Simon; Ebersbach, Gitte; Borch, Jonas

    2007-01-01

    The double par locus of Escherichia coli virulence factor pB171 consists of two adjacent and oppositely oriented par loci of different types, called par1 and par2. par1 encodes an actin ATPase (ParM), and par2 encodes an oscillating, MinD-like ATPase (ParA). The par loci share a central cis-actin...... well with the observed transcriptional regulation of the par operons in vivo and in vitro. Integration host factor (IHF) was identified as a novel factor involved in par2-mediated plasmid partitioning....

  8. Maternal Depression, Locus of Control, and Emotion Regulatory Strategy as Predictors of Preschoolers' Internalizing Problems

    Science.gov (United States)

    Coyne, Lisa W.; Thompson, Alysha D.

    2011-01-01

    Childhood internalizing problems may occur as early as preschool, tend to be stable over time, and undermine social and academic functioning. Parent emotion regulatory behaviors may contribute to child internalizing problems and may be especially important during the preschool years when parents model emotion coping and regulation for their…

  9. Use of an EZ-Tn5-based random mutagenesis system to identify a novel toxin regulatory locus in Clostridium perfringens strain 13.

    Directory of Open Access Journals (Sweden)

    Jorge E Vidal

    2009-07-01

    Full Text Available Although useful for probing bacterial pathogenesis and physiology, current random mutagenesis systems suffer limitations for studying the toxin-producing bacterium Clostridium perfringens.An EZ-Tn5-based random mutagenesis approach was developed for use in C. perfringens. This mutagenesis system identified a new regulatory locus controlling toxin production by strain 13, a C. perfringens type A strain. The novel locus, encoding proteins with homology to the AgrB and AgrD components of the Agr quorum sensing system of Staphylococcus aureus and two hypothetical proteins, was found to regulate early production of both alpha toxin and perfringolysin O (PFO by strain 13. PFO production by the strain 13 DeltaagrB mutant could be restored by genetic complementation or by physical complementation, i.e. by co-culture of the strain 13 DeltaagrB mutant with a pfoA mutant of either strain 13 or C. perfringens type C CN3685. A similar AgrB- and AgrD-encoding locus is identifiable in all sequenced C. perfringens strains, including type B, C, D, and E isolates, suggesting this regulatory locus contributes to toxin regulation by most C. perfringens strains. In strain 13, the agrB and agrD genes were found to be co-transcribed in an operon with two upstream genes encoding hypothetical proteins.The new Tn5-based random mutagenesis system developed in this study is more efficient and random than previously reported C. perfringens random mutagenesis approaches. It allowed identification of a novel C. perfringens toxin regulatory locus with homology to the Agr system of S. aureus and which functions as expected of an Agr-like quorum sensing system. Since previous studies have shown that alpha toxin and perfringolysin O are responsible for strain 13-induced clostridial myonecrosis in the mouse model, the new agr regulatory locus may have importance for strain 13 virulence.

  10. Regulatory cross-talk in the double par locus of plasmid pB171

    DEFF Research Database (Denmark)

    Ringgaard, Simon; Ebersbach, Gitte; Borch, Jonas

    2007-01-01

    The double par locus of Escherichia coli virulence factor pB171 consists of two adjacent and oppositely oriented par loci of different types, called par1 and par2. par1 encodes an actin ATPase (ParM), and par2 encodes an oscillating, MinD-like ATPase (ParA). The par loci share a central cis......-acting region of approximately 200 bp, called parC1, located between the two par loci. An additional cis-acting region, parC2, is located downstream of the parAB operon of par2. Here we show that ParR of par1 and ParB of par2 bind cooperatively to unrelated sets of direct repeats in parC1 to form the cognate...... partition and promoter repression complexes. Surprisingly, ParB repressed transcription of the noncognate par operon, indicating cross-talk and possibly epistasis between the two systems. The par promoters, P1 and P2, affected each other negatively. The DNA binding activities of ParR and ParB correlated...

  11. Evidence for regulatory diversity and auto-regulation at the TAC1 locus in sensory neurones

    Directory of Open Access Journals (Sweden)

    Ross Ruth

    2011-02-01

    Full Text Available Abstract The neuropeptide substance-P (SP is expressed from the TAC1 gene in sensory neurones where it acts as a key modulator of neurogenic inflammation. The promoter of TAC1 (TAC1prom plays a central role in the regulation of the TAC1 gene but requires the presence of a second regulatory element; ECR2, to support TAC1 expression in sensory neurones and to respond appropriately to signalling pathways such as MAPkinases and noxious induction by capsaicin. We examined whether the effect of capsaicin on ECR2-TAC1prom activity in larger diameter neurones was cell autonomous or non- cell autonomous. We demonstrate that TRPV1 is not expressed in all the same cells as SP following capsaicin induction suggesting the presence of a non-cell autonomous mechanism for TAC1 up-regulation following capsaicin induction. In addition, we demonstrate that induction of SP and ECR1-TAC1prom activity in these larger diameter neurones can be induced by potassium depolarisation suggesting that, in addition to capsaicin induction, transgene activity may be modulated by voltage gated calcium channels. Furthermore, we show that NK1 is expressed in all SP- expressing cells after capsaicin induction and that an agonist of NK1 can activate both SP and the transgene in larger diameter neurones. These observations suggest the presence of an autocrine loop that controls the expression of the TAC1 promoter in sensory neurones. In contrast, induction of the TAC1 promoter by LPS was not dependent on ECR2 and did not occur in large diameter neurones. These studies demonstrate the diversity of mechanisms modulating the activity of the TAC1 promoter and provide novel directions for the development of new anti-inflammatory therapies.

  12. Righting the ADA

    Science.gov (United States)

    National Council on Disability, 2004

    2004-01-01

    Many Americans with disabilities feel that a series of negative court decisions is reducing their status to that of "second-class citizens," a status that the Americans with Disabilities Act (ADA) was supposed to remedy forever. In this report, the National Council on Disability (NCD), which first proposed the enactment of an ADA and…

  13. Transition to Ada

    Science.gov (United States)

    1993-02-01

    from design to implementation through integration with Cadre’s Ada Source Builder (ASB) and Design Sensitive Editor ( DSE ). When used with the ASG...inserted into the generated code using the DSE , but only within the code frames. The DSE automatically detects Ada syntax errors, and may be configured...Contains summaries of current approaches to likely problems, indications of deficiencies in existing knowledge, and checklists of questions to ask when

  14. The Small Regulatory RNA Spot42 Inhibits Indole Biosynthesis to Negatively Regulate the Locus of Enterocyte Effacement of Enteropathogenic Escherichia coli

    Directory of Open Access Journals (Sweden)

    Shantanu Bhatt

    2017-12-01

    Full Text Available The locus of enterocyte effacement is necessary for enteropathogenic Escherichia coli (EPEC to form attaching and effacing (A/E lesions. A/E lesions are characterized by intimate bacterial adherence to intestinal cells and destruction of microvilli, which leads to diarrhea. Therefore, studies interrogating the regulation of the locus of enterocyte effacement (LEE are critical for understanding the molecular epidemiology of EPEC infections and developing interventional strategies. Hitherto, most studies have centered on protein-based regulators, whereas the role of small regulatory RNAs remains underappreciated. Previously, we identified the first sRNAs—MgrR, RyhB, and McaS—that regulate the LEE of EPEC. This study was undertaken to identify additional sRNAs that impact the LEE. Our results suggest that the catabolite-responsive sRNA, Spot42, indirectly controls the LEE by inhibiting synthesis of its inducer, indole. Spot42 base-pairs with the tnaCAB mRNA and presumably destabilizes the transcript, thereby preventing expression of the regulatory and structural proteins that are involved in the import and hydrolysis of tryptophan into indole. The absence of intracellular indole leads to reduced transcription of the LEE1-encoded master transcriptional activator Ler, thereby maintaining the LEE in its silenced state and delaying A/E lesion morphogenesis. Our results highlight the importance of riboregulators that synchronize metabolic and virulence pathways in bacterial infection.

  15. Software engineering capability for Ada (GRASP/Ada Tool)

    Science.gov (United States)

    Cross, James H., II

    1995-01-01

    The GRASP/Ada project (Graphical Representations of Algorithms, Structures, and Processes for Ada) has successfully created and prototyped a new algorithmic level graphical representation for Ada software, the Control Structure Diagram (CSD). The primary impetus for creation of the CSD was to improve the comprehension efficiency of Ada software and, as a result, improve reliability and reduce costs. The emphasis has been on the automatic generation of the CSD from Ada PDL or source code to support reverse engineering and maintenance. The CSD has the potential to replace traditional prettyprinted Ada Source code. A new Motif compliant graphical user interface has been developed for the GRASP/Ada prototype.

  16. Ada-Okungbowa, CI

    African Journals Online (AJOL)

    Ada-Okungbowa, CI. Vol 4, No 1-2 (1998) - Articles The market structure, conduct and performance for Yam in Ondo state, Nigeria Abstract PDF. ISSN: 1117-9996. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and ...

  17. Ada, Fwangyil Gloria

    African Journals Online (AJOL)

    Ada, Fwangyil Gloria. Vol 8, No 3 (2011) - Articles A Critical Survey of Selected Texts on the Growth of Feminism in Nigeria Abstract. ISSN: 1813-2227. AJOL African Journals Online. HOW TO USE AJOL... for Researchers · for Librarians · for Authors · FAQ's · More about AJOL · AJOL's Partners · Terms and Conditions of Use ...

  18. Rearrangements of 2.5 Kilobases of Noncoding DNA from the Drosophila even-skipped Locus Define Predictive Rules of Genomic cis-Regulatory Logic

    Science.gov (United States)

    Kim, Ah-Ram; Martinez, Carlos; Ionides, John; Ramos, Alexandre F.; Ludwig, Michael Z.; Ogawa, Nobuo; Sharp, David H.; Reinitz, John

    2013-01-01

    Rearrangements of about 2.5 kilobases of regulatory DNA located 5′ of the transcription start site of the Drosophila even-skipped locus generate large-scale changes in the expression of even-skipped stripes 2, 3, and 7. The most radical effects are generated by juxtaposing the minimal stripe enhancers MSE2 and MSE3 for stripes 2 and 3 with and without small “spacer” segments less than 360 bp in length. We placed these fusion constructs in a targeted transformation site and obtained quantitative expression data for these transformants together with their controlling transcription factors at cellular resolution. These data demonstrated that the rearrangements can alter expression levels in stripe 2 and the 2–3 interstripe by a factor of more than 10. We reasoned that this behavior would place tight constraints on possible rules of genomic cis-regulatory logic. To find these constraints, we confronted our new expression data together with previously obtained data on other constructs with a computational model. The model contained representations of thermodynamic protein–DNA interactions including steric interference and cooperative binding, short-range repression, direct repression, activation, and coactivation. The model was highly constrained by the training data, which it described within the limits of experimental error. The model, so constrained, was able to correctly predict expression patterns driven by enhancers for other Drosophila genes; even-skipped enhancers not included in the training set; stripe 2, 3, and 7 enhancers from various Drosophilid and Sepsid species; and long segments of even-skipped regulatory DNA that contain multiple enhancers. The model further demonstrated that elevated expression driven by a fusion of MSE2 and MSE3 was a consequence of the recruitment of a portion of MSE3 to become a functional component of MSE2, demonstrating that cis-regulatory “elements” are not elementary objects. PMID:23468638

  19. Ada Lovelace Poster

    OpenAIRE

    Charman-Anderson, Suw

    2016-01-01

    Who was Ada Lovelace? What were her greatest achievements? This ‘infoposter’ describes Lovelace’s achievements and describes why she’s thought of as the world’s first computer programmer.Available to buy from RedBubble as a poster, photographic print, art print, framed print, canvas print, metal print, greetings card, spiral bound notebook or hardback journal. 

  20. Differential contribution of cis-regulatory elements to higher order chromatin structure and expression of the CFTR locus

    OpenAIRE

    Yang, Rui; Kerschner, Jenny L.; Gosalia, Nehal; Neems, Daniel; Gorsic, Lidija K.; Safi, Alexias; Crawford, Gregory E.; Kosak, Steven T.; Leir, Shih-Hsing; Harris, Ann

    2015-01-01

    Higher order chromatin structure establishes domains that organize the genome and coordinate gene expression. However, the molecular mechanisms controlling transcription of individual loci within a topological domain (TAD) are not fully understood. The cystic fibrosis transmembrane conductance regulator (CFTR) gene provides a paradigm for investigating these mechanisms. CFTR occupies a TAD bordered by CTCF/cohesin binding sites within which are cell-type-selective cis-regulatory elements for ...

  1. Comparative analysis reveals regulatory motifs at the ainS/ainR pheromone-signaling locus of Vibrio fischeri.

    Science.gov (United States)

    Kimbrough, John H; Stabb, Eric V

    2017-09-15

    Vibrio fischeri uses the AinS/AinR pheromone-signaling system to control bioluminescence and other symbiotic colonization factors. The Ain system is thought to initiate cell-cell signaling at moderate cell densities and to prime the LuxI/LuxR signaling system. Here we compared and analyzed the ain locus from two V. fischeri strains and a Vibrio salmonicida strain to explore ain regulation. The ainS and ainR genes were predicted to constitute an operon, which we corroborated using RT-PCR. Comparisons between strains revealed a stark area of conservation across the ainS-ainR junction, including a large inverted repeat in ainR. We found that this inverted repeat in cis can affect accumulation of the AinS-generated pheromone N-octanoyl homoserine lactone, which may account for the previously unexplained low-signal phenotype of a ∆ainR mutant, although the mechanism behind this regulation remains elusive. We also extended the previous observation of a possible "lux box" LuxR binding site upstream of ainS by showing the conservation of this site as well as a second putative lux box. Using a plasmid-based reporter we found that LuxR can mediate repression of ainS, providing a negative feedback mechanism in the Ain/Lux signaling cascade. Our results provide new insights into the regulation, expression, and evolution of ainSR.

  2. The function of the conserved regulatory element within the second intron of the mammalian Csf1r locus.

    Science.gov (United States)

    Sauter, Kristin A; Bouhlel, M Amine; O'Neal, Julie; Sester, David P; Tagoh, Hiromi; Ingram, Richard M; Pridans, Clare; Bonifer, Constanze; Hume, David A

    2013-01-01

    The gene encoding the receptor for macrophage colony-stimulating factor (CSF-1R) is expressed exclusively in cells of the myeloid lineages as well as trophoblasts. A conserved element in the second intron, Fms-Intronic Regulatory Element (FIRE), is essential for macrophage-specific transcription of the gene. However, the molecular details of how FIRE activity is regulated and how it impacts the Csf1r promoter have not been characterised. Here we show that agents that down-modulate Csf1r mRNA transcription regulated promoter activity altered the occupancy of key FIRE cis-acting elements including RUNX1, AP1, and Sp1 binding sites. We demonstrate that FIRE acts as an anti-sense promoter in macrophages and reversal of FIRE orientation within its native context greatly reduced enhancer activity in macrophages. Mutation of transcription initiation sites within FIRE also reduced transcription. These results demonstrate that FIRE is an orientation-specific transcribed enhancer element.

  3. The function of the conserved regulatory element within the second intron of the mammalian Csf1r locus.

    Directory of Open Access Journals (Sweden)

    Kristin A Sauter

    Full Text Available The gene encoding the receptor for macrophage colony-stimulating factor (CSF-1R is expressed exclusively in cells of the myeloid lineages as well as trophoblasts. A conserved element in the second intron, Fms-Intronic Regulatory Element (FIRE, is essential for macrophage-specific transcription of the gene. However, the molecular details of how FIRE activity is regulated and how it impacts the Csf1r promoter have not been characterised. Here we show that agents that down-modulate Csf1r mRNA transcription regulated promoter activity altered the occupancy of key FIRE cis-acting elements including RUNX1, AP1, and Sp1 binding sites. We demonstrate that FIRE acts as an anti-sense promoter in macrophages and reversal of FIRE orientation within its native context greatly reduced enhancer activity in macrophages. Mutation of transcription initiation sites within FIRE also reduced transcription. These results demonstrate that FIRE is an orientation-specific transcribed enhancer element.

  4. Distributed and parallel Ada and the Ada 9X recommendations

    Science.gov (United States)

    Volz, Richard A.; Goldsack, Stephen J.; Theriault, R.; Waldrop, Raymond S.; Holzbacher-Valero, A. A.

    1992-01-01

    Recently, the DoD has sponsored work towards a new version of Ada, intended to support the construction of distributed systems. The revised version, often called Ada 9X, will become the new standard sometimes in the 1990s. It is intended that Ada 9X should provide language features giving limited support for distributed system construction. The requirements for such features are given. Many of the most advanced computer applications involve embedded systems that are comprised of parallel processors or networks of distributed computers. If Ada is to become the widely adopted language envisioned by many, it is essential that suitable compilers and tools be available to facilitate the creation of distributed and parallel Ada programs for these applications. The major languages issues impacting distributed and parallel programming are reviewed, and some principles upon which distributed/parallel language systems should be built are suggested. Based upon these, alternative language concepts for distributed/parallel programming are analyzed.

  5. Ada in the PAX Environment

    Science.gov (United States)

    1994-04-01

    individual styles and talents, it is argued. Furthermore, DOD believes that standardizat on will turn programming from an art into a discipline...called IntegrAda . The AETECH environment is probably r " most developer-friendly of all the Ada compilers for microcomputers. The AETECH compiler

  6. Ada Linear-Algebra Program

    Science.gov (United States)

    Klumpp, A. R.; Lawson, C. L.

    1988-01-01

    Routines provided for common scalar, vector, matrix, and quaternion operations. Computer program extends Ada programming language to include linear-algebra capabilities similar to HAS/S programming language. Designed for such avionics applications as software for Space Station.

  7. An Ada programming support environment

    Science.gov (United States)

    Tyrrill, AL; Chan, A. David

    1986-01-01

    The toolset of an Ada Programming Support Environment (APSE) being developed at North American Aircraft Operations (NAAO) of Rockwell International, is described. The APSE is resident on three different hosts and must support developments for the hosts and for embedded targets. Tools and developed software must be freely portable between the hosts. The toolset includes the usual editors, compilers, linkers, debuggers, configuration magnagers, and documentation tools. Generally, these are being supplied by the host computer vendors. Other tools, for example, pretty printer, cross referencer, compilation order tool, and management tools were obtained from public-domain sources, are implemented in Ada and are being ported to the hosts. Several tools being implemented in-house are of interest, these include an Ada Design Language processor based on compilable Ada. A Standalone Test Environment Generator facilitates test tool construction and partially automates unit level testing. A Code Auditor/Static Analyzer permits the Ada programs to be evaluated against measures of quality. An Ada Comment Box Generator partially automates generation of header comment boxes.

  8. Paranoia.Ada: Sample output reports

    Science.gov (United States)

    1986-01-01

    Paranoia.Ada is a program to diagnose floating point arithmetic in the context of the Ada programming language. The program evaluates the quality of a floating point arithmetic implementation with respect to the proposed IEEE Standards P754 and P854. Paranoia.Ada is derived from the original BASIC programming language version of Paranoia. The Paranoia.Ada replicates in Ada the test algorithms originally implemented in BASIC and adheres to the evaluation criteria established by W. M. Kahan. Paranoia.Ada incorporates a major structural redesign and employs applicable Ada architectural and stylistic features.

  9. ART-Ada design project, phase 2

    Science.gov (United States)

    Lee, S. Daniel; Allen, Bradley P.

    1990-01-01

    Interest in deploying expert systems in Ada has increased. An Ada based expert system tool is described called ART-Ada, which was built to support research into the language and methodological issues of expert systems in Ada. ART-Ada allows applications of an existing expert system tool called ART-IM (Automated Reasoning Tool for Information Management) to be deployed in various Ada environments. ART-IM, a C-based expert system tool, is used to generate Ada source code which is compiled and linked with an Ada based inference engine to produce an Ada executable image. ART-Ada is being used to implement several expert systems for NASA's Space Station Freedom Program and the U.S. Air Force.

  10. Ada (Trade Name) Bibliography. Volume 3.

    Science.gov (United States)

    1986-02-01

    STUDY WHITE , TIM, ADA-EUROPE 4646 -02 ADA-EUROPE GUIDELINES FOR ADA COMPILER SPECIFICATION AND SELECTION WHITEHILL , STEPHEN B., U. OF CALIFORNIA AT IRVINE...ADA FOR PROGRAMMERS OLSEN, ERIC W.; WHITEHILL , STEPHEN B. DOCUMENT NUMBER: 5404 TYPE: TEXT The Reference Manual for Ada Programming Language (LRM) is...Bibliography Volume 111 41 formatted reports provide critical unit information used by the National Command Authority and Joint Chiefs of Staff in assessing

  11. Ada (Trademark) Compiler Validation Summary Report.

    Science.gov (United States)

    1987-04-30

    identifies and rejects illegal language constructs. The testing also identifies behaviour that is implementation dependent but permitted by the Ada Standard... behaviour is allowed by the Ada Standard Testing of this compiler was conducted by NCC under the direction of the AVF according to policies and...subject compiler has no nonconformities to the Ada Standard other than those presented. Copies of this report are available to the public from: Ada

  12. Autoimmune dysregulation and purine metabolism in adenosine deaminase (ADA-deficiency

    Directory of Open Access Journals (Sweden)

    Aisha Vanessa Sauer

    2012-08-01

    Full Text Available Genetic defects in the adenosine deaminase (ADA gene are among the most common causes for severe combined immunodeficiency (SCID. ADA-SCID patients suffer from lymphopenia, severely impaired cellular and humoral immunity, failure to thrive and recurrent infections. Currently available therapeutic options for this otherwise fatal disorder include bone marrow transplantation (BMT, enzyme replacement therapy with bovine ADA (PEG-ADA or hematopoietic stem cell gene therapy (HSC-GT. Although varying degrees of immune reconstitution can be achieved by these treatments, breakdown of tolerance is a major concern in ADA-SCID. Immune dysregulation such as autoimmune hypothyroidism, diabetes mellitus, hemolytic anemia, and immune thrombocytopenia are frequently observed in milder forms of the disease. However, several reports document similar complications also in patients on long-term PEG-ADA and after BMT or GT treatment.A skewed repertoire and decreased immune functions have been implicated in autoimmunity observed in certain B-cell and/or T-cell immunodeficiencies, but it remains unclear to what extent specific mechanisms of tolerance are affected in ADA deficiency. Herein we provide an overview about ADA-SCID and the autoimmune manifestations reported in these patients before and after treatment. We also assess the value of the ADA-deficient mouse model as a useful tool to study both immune and metabolic disease mechanisms. With focus on regulatory T and B cells we discuss the lymphocyte subpopulations particularly prone to contribute to the loss of self-tolerance and onset of autoimmunity in ADA deficiency. Moreover we address which aspects of immune dysregulation are specifically related to alterations in purine metabolism caused by the lack of ADA and the subsequent accumulation of metabolites with immunomodulatory properties.

  13. The predicted protein product of a pathogenicity locus from Pseudomonas syringae pv. phaseolicola is homologous to a highly conserved domain of several procaryotic regulatory proteins.

    OpenAIRE

    Grimm, C.; Panopoulos, N J

    1989-01-01

    A ca. 20-kilobase (kb) region (hrp) that controls the interaction of Pseudomonas syringae pv. phaseolicola with its host (pathogenicity) and nonhost plants (hypersensitive reaction) was previously cloned and partially characterized. In this study we defined the limits and determined the nucleotide sequence of a hrp locus (hrpS), located near the right end of the hrp cluster. The largest open reading frame (ORF302) in hrpS has a coding capacity for a 302-amino-acid polypeptide. The predicted a...

  14. Ada Software Design Methods Formulation.

    Science.gov (United States)

    1982-10-01

    of the language, which are potentially unsafe and therefore within the domain of more skilled designers. 1094-2.1 3-24 CLL 0- IW &A. I -. CZ 0 u u 4... LANGAUGE FEATURES (see Table 3-2d) a PROGRAM UNITS PROGRAMMING CONSTRUCTS a STRONG TYPING (see Table 3-2e) @ EXCEPTIONS * MACHINE DEPENDENT FEATURES...MANAGEMENT TOOLS (see Table 3-3b) * DATABASE a PROTECTION PROGRAMMING LANGUAGES * ADDING APSE TOOLS (see Table 3-3c) ADA LANGAUGE FEATURES METHODOLOGIES

  15. A Comparison of Ada 83 and C++

    Science.gov (United States)

    1991-06-01

    developing large, complex, software systems with long lifetimes. Those interviewed for this study who are familiar with both Ada and C++ believe that Ada is...with those who are familiar with both languages, there was a clear preference for using Ada for large complex systems with long lifetimes. These...University, December 1990 Additions by Nelson H. Weiderman, June 1991. Chile Empresa Nacional de Aeronautica (ENAER), real-time avionics system, Data

  16. ART/Ada design project, phase 1

    Science.gov (United States)

    1989-01-01

    An Ada-Based Expert System Building Tool Design Research Project was conducted. The goal was to investigate various issues in the context of the design of an Ada-based expert system building tool. An attempt was made to achieve a comprehensive understanding of the potential for embedding expert systems in Ada systems for eventual application in future projects. The current status of the project is described by introducing an operational prototype, ART/Ada. How the project was conducted is explained. The performance of the prototype is analyzed and compared with other related works. Future research directions are suggested.

  17. Paranoia.Ada: A diagnostic program to evaluate Ada floating-point arithmetic

    Science.gov (United States)

    Hjermstad, Chris

    1986-01-01

    Many essential software functions in the mission critical computer resource application domain depend on floating point arithmetic. Numerically intensive functions associated with the Space Station project, such as emphemeris generation or the implementation of Kalman filters, are likely to employ the floating point facilities of Ada. Paranoia.Ada appears to be a valuabe program to insure that Ada environments and their underlying hardware exhibit the precision and correctness required to satisfy mission computational requirements. As a diagnostic tool, Paranoia.Ada reveals many essential characteristics of an Ada floating point implementation. Equipped with such knowledge, programmers need not tremble before the complex task of floating point computation.

  18. Hfq and three Hfq-dependent small regulatory RNAs-MgrR, RyhB and McaS-coregulate the locus of enterocyte effacement in enteropathogenic Escherichia coli.

    Science.gov (United States)

    Bhatt, Shantanu; Egan, Marisa; Ramirez, Jasmine; Xander, Christian; Jenkins, Valerie; Muche, Sarah; El-Fenej, Jihad; Palmer, Jamie; Mason, Elisabeth; Storm, Elizabeth; Buerkert, Thomas

    2017-02-01

    Enteropathogenic Escherichia coli (EPEC) is a significant cause of infantile diarrhea and death in developing countries. The pathogenicity island locus of enterocyte effacement (LEE) is essential for EPEC to cause diarrhea. Besides EPEC, the LEE is also present in other gastrointestinal pathogens, most notably enterohemorrhagic E. coli (EHEC). Whereas transcriptional control of the LEE has been meticulously examined, posttranscriptional regulation, including the role of Hfq-dependent small RNAs, remains undercharacterized. However, the past few years have witnessed a surge in the identification of riboregulators of the LEE in EHEC. Contrastingly, the posttranscriptional regulatory landscape of EPEC remains cryptic. Here we demonstrate that the RNA-chaperone Hfq represses the LEE of EPEC by targeting the 5' untranslated leader region of grlR in the grlRA mRNA. Three conserved small regulatory RNAs (sRNAs)-MgrR, RyhB and McaS-are involved in the Hfq-dependent regulation of grlRA MgrR and RyhB exert their effects by directly base-pairing to the 5' region of grlR Whereas MgrR selectively represses grlR but activates grlA, RyhB represses gene expression from the entire grlRA transcript. Meanwhile, McaS appears to target the grlRA mRNA indirectly. Thus, our results provide the first definitive evidence that implicates multiple sRNAs in regulating the LEE and the resulting virulence of EPEC. © FEMS 2016. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

  19. A distributed programming environment for Ada

    Science.gov (United States)

    Brennan, Peter; Mcdonnell, Tom; Mcfarland, Gregory; Timmins, Lawrence J.; Litke, John D.

    1986-01-01

    Despite considerable commercial exploitation of fault tolerance systems, significant and difficult research problems remain in such areas as fault detection and correction. A research project is described which constructs a distributed computing test bed for loosely coupled computers. The project is constructing a tool kit to support research into distributed control algorithms, including a distributed Ada compiler, distributed debugger, test harnesses, and environment monitors. The Ada compiler is being written in Ada and will implement distributed computing at the subsystem level. The design goal is to provide a variety of control mechanics for distributed programming while retaining total transparency at the code level.

  20. Development of an Ada programming support environment database SEAD (Software Engineering and Ada Database) administration manual

    Science.gov (United States)

    Liaw, Morris; Evesson, Donna

    1988-01-01

    Software Engineering and Ada Database (SEAD) was developed to provide an information resource to NASA and NASA contractors with respect to Ada-based resources and activities which are available or underway either in NASA or elsewhere in the worldwide Ada community. The sharing of such information will reduce duplication of effort while improving quality in the development of future software systems. SEAD data is organized into five major areas: information regarding education and training resources which are relevant to the life cycle of Ada-based software engineering projects such as those in the Space Station program; research publications relevant to NASA projects such as the Space Station Program and conferences relating to Ada technology; the latest progress reports on Ada projects completed or in progress both within NASA and throughout the free world; Ada compilers and other commercial products that support Ada software development; and reusable Ada components generated both within NASA and from elsewhere in the free world. This classified listing of reusable components shall include descriptions of tools, libraries, and other components of interest to NASA. Sources for the data include technical newletters and periodicals, conference proceedings, the Ada Information Clearinghouse, product vendors, and project sponsors and contractors.

  1. Software engineering and Ada in design

    Science.gov (United States)

    Oneill, Don

    1986-01-01

    Modern software engineering promises significant reductions in software costs and improvements in software quality. The Ada language is the focus for these software methodology and tool improvements. The IBM FSD approach, including the software engineering practices that guide the systematic design and development of software products and the management of the software process are examined. The revised Ada design language adaptation is revealed. This four level design methodology is detailed including the purpose of each level, the management strategy that integrates the software design activity with the program milestones, and the technical strategy that maps the Ada constructs to each level of design. A complete description of each design level is provided along with specific design language recording guidelines for each level. Finally, some testimony is offered on education, tools, architecture, and metrics resulting from project use of the four level Ada design language adaptation.

  2. ADA dental product evaluation: case history.

    Science.gov (United States)

    Barnett, M L

    1992-01-01

    The ADA Acceptance Programs entail a rigorous evaluation of products and offer clear benefits to manufacturers, dental professionals, and consumers alike. This paper outlines the implications of the ADA product-evaluation programs for each of these three constituencies and concludes that while there may be an occasional downside from the manufacturer's standpoint, their net effect is to provide assurances that products are safe, efficacious, and promoted properly.

  3. A role for the gene regulatory module microRNA172/TARGET OF EARLY ACTIVATION TAGGED 1/FLOWERING LOCUS T (miRNA172/TOE1/FT) in the feeding sites induced by Meloidogyne javanica in Arabidopsis thaliana.

    Science.gov (United States)

    Díaz-Manzano, Fernando E; Cabrera, Javier; Ripoll, Juan-José; Del Olmo, Iván; Andrés, Mari Fe; Silva, Ana Cláudia; Barcala, Marta; Sánchez, María; Ruíz-Ferrer, Virginia; de Almeida-Engler, Janice; Yanofsky, Martin F; Piñeiro, Manuel; Jarillo, Jose Antonio; Fenoll, Carmen; Escobar, Carolina

    2018-01-01

    Root knot nematodes (RKNs) penetrate into the root vascular cylinder, triggering morphogenetic changes to induce galls, de novo formed 'pseudo-organs' containing several giant cells (GCs). Distinctive gene repression events observed in early gall/GCs development are thought to be mediated by post-transcriptional silencing via microRNAs (miRNAs), a process that is far from being fully characterized. Arabidopsis thaliana backgrounds with altered activities based on target 35S::MIMICRY172 (MIM172), 35S::TARGET OF EARLY ACTIVATION TAGGED 1 (TOE1)-miR172-resistant (35S::TOE1R ) and mutant (flowering locus T-10 (ft-10)) lines were used for functional analysis of nematode infective and reproductive parameters. The GUS-reporter lines, MIR172A-E::GUS, treated with auxin (IAA) and an auxin-inhibitor (a-(phenyl ethyl-2-one)-indole-3-acetic acid (PEO-IAA)), together with the MIR172C AuxRE::GUS line with two mutated auxin responsive elements (AuxREs), were assayed for nematode-dependent gene expression. Arabidopsis thaliana backgrounds with altered expression of miRNA172, TOE1 or FT showed lower susceptibility to the RKNs and smaller galls and GCs. MIR172C-D::GUS showed restricted promoter activity in galls/GCs that was regulated by auxins through auxin-responsive factors. IAA induced their activity in galls while PEO-IAA treatment and mutations in AuxRe motifs abolished it. The results showed that the regulatory module miRNA172/TOE1/FT plays an important role in correct GCs and gall development, where miRNA172 is modulated by auxins. © 2017 The Authors. New Phytologist © 2017 New Phytologist Trust.

  4. Effect of ADA1 mother-fetus and wife-husband phenotypic differences on the ratio birth weight/placental weight in fertile women and on reproductive success in couples with RSA.

    Science.gov (United States)

    Gloria-Bottini, Fulvia; Nicotra, Maria; Amante, Ada; Ambrosi, Sara; Cozzoli, Eliana; Saccucci, Patrizia; Bottini, Egidio; Magrini, Andrea

    2012-01-01

    To study the effect Adenosine Deaminase locus 1 (ADA(1)) mother-fetus and wife-husband phenotypic differences on the ratio Birth Weight/Placental Weight (BW/PW) in fertile women and on reproductive success in couples with repeated spontaneous abortion (RSA). 209 couples with primary RSA and a consecutive series of 379 healthy puerperae with their newborn infants from the White Caucasian population of central Italy were studied. In primary RSA women reproductive success was indicated by the presence of at least one live-born infant within 5 years of follow up. Two way contingency tables were analyzed by chi-square. The proportion of primary RSA couples with at least a live-born infant shows the highest value in couples mother ADA(1)1/father carrier of ADA(1)*2 allele (55.2%) and the lowest value in reciprocal couples mother carrier of ADA(1)*2 allele /father ADA(1)1 (18.7%) (O.R. = 5.33; P = 0.023). The highest ratio BW/PW is observed in the class mother ADA(1)1/newborn carrier of ADA(1)*2 allele while the lowest ratio is observed in the reciprocal class mother carrier of ADA(1)*2 allele/ newborn ADA(1)1. Differences between mother and fetus in ADA(1) phenotype may influence the ratio BW/PW in healthy women and reproductive success in RSA women. Copyright © 2012 Wiley Periodicals, Inc.

  5. Ada 9X Project Revision Request Report. Supplement 1

    Science.gov (United States)

    1990-01-01

    Rendezvous. 16-56 Supplement I Ada 9X Revision Request 0332 UNSIGNED INTEGER DATE: April 4, 1989 NAME: Toomas Kaer (Endorsed by Ada-Europe Ada9X working...group) ADDRESS: Ericsson Radar Electronics AB S-431 84 Molndal Sweden TELEPHONE: +46 31-671543 +46 31-276043 (fax) E-mail: Kaer @MOERE3.ERICSSON.SE E...58 Supplement I Ada 9X Revision Request 0337 DYNAMIC PRIORITIES DATE: April 27, 1989 NAME: Toomas Kaer (Endorsed by Ada-Europe Ada9X working group

  6. KYTC sidewalk and curb ramp inventory for ADA compliance.

    Science.gov (United States)

    2017-09-01

    The Americans with Disabilities Act of 1990 (ADA) requires that all public and private organizations providing services to the public ensure their facilities and infrastructure comply with regulations set forth therein. The ADA requires that a transi...

  7. Electronic Commerce Removing Regulatory Impediments

    Science.gov (United States)

    1992-05-01

    AD-A252 691 ELECTRONIC COMMERCE Removing Regulatory Impediments ~DuiG A% ELECTE I JUL1 8 1992 0 C D Daniel J. Drake John A. Ciucci ... - ""N ST AT KE...Management Institute 6400 Goldsboro Road Bethesda, Maryland 20817-5886 92 LMI Executive Summary ELECTRONIC COMMERCE : REMOVING REGULATORY IMPEDIMENTS... Electronic Commerce techniques, such as electronic mail and electronic data interchange (EDI), enable Government agencies to conduct business without the

  8. Ada in Introductory Computer Science Courses

    Science.gov (United States)

    1993-01-01

    nd hi ha c AdaVmansg Meridian Software. Yes p~cIane.of -my Lft- mom"m eIAgura Kills CA soon Maclintos (unader MAC OS) buks* udPL o )- i anlyYes...Yes Cross-comipiler tnas people The but prugmiisan - i by Waltibmn. MA Va series gea ’at die -m at two pepl - 0A tý NPWI tI I A I OM11b SMis o NYU

  9. Ada (Trade Name) Bibliography. Volume 2.

    Science.gov (United States)

    1984-03-01

    MILITARY COMPUTERS IN TRANSITION: STAINDARDS AND STRATEGY BECKER, LOUISE GIOVANE CONCEPTS: THE JRNL OF DEF. SYST. ACQ. MANAGEMENT, VOL 5, ISSUE 4, PP...SPECIFICATION LANGUAGE S BECKER. LOUISE GIOVANE . CONGRESSIONAL RESEARCH SERVICE OF THE LIB OF CONGRESS 4252-2 MILITARY COMPUTERS IN TRANSITION...SOFTWARE ARCHITECTURE STUDY. PART I. FINAL REPORT BRAUN, CHRISTINE L., SOFTECH,INC. TOTTEN POND RDWALTHAMMA 02154 3249-1 ADA: PROGRAMMING IN THE 80’S

  10. The Katydid system for compiling KEE applications to Ada

    Science.gov (United States)

    Filman, Robert E.; Bock, Conrad; Feldman, Roy

    1990-01-01

    Components of a system known as Katydid are developed in an effort to compile knowledge-based systems developed in a multimechanism integrated environment (KEE) to Ada. The Katydid core is an Ada library supporting KEE object functionality, and the other elements include a rule compiler, a LISP-to-Ada translator, and a knowledge-base dumper. Katydid employs translation mechanisms that convert LISP knowledge structures and rules to Ada and utilizes basic prototypes of a run-time KEE object-structure library module for Ada. Preliminary results include the semiautomatic compilation of portions of a simple expert system to run in an Ada environment with the described algorithms. It is suggested that Ada can be employed for AI programming and implementation, and the Katydid system is being developed to include concurrency and synchronization mechanisms.

  11. Object-oriented programming with mixins in Ada

    Science.gov (United States)

    Seidewitz, ED

    1992-01-01

    Recently, I wrote a paper discussing the lack of 'true' object-oriented programming language features in Ada 83, why one might desire them in Ada, and how they might be added in Ada 9X. The approach I took in this paper was to build the new object-oriented features of Ada 9X as much as possible on the basic constructs and philosophy of Ada 83. The object-oriented features proposed for Ada 9X, while different in detail, are based on the same kind of approach. Further consideration of this approach led me on a long reflection on the nature of object-oriented programming and its application to Ada. The results of this reflection, presented in this paper, show how a fairly natural object-oriented style can indeed be developed even in Ada 83. The exercise of developing this style is useful for at least three reasons: (1) it provides a useful style for programming object-oriented applications in Ada 83 until new features become available with Ada 9X; (2) it demystifies many of the mechanisms that seem to be 'magic' in most object-oriented programming languages by making them explicit; and (3) it points out areas that are and are not in need of change in Ada 83 to make object-oriented programming more natural in Ada 9X. In the next four sections I will address in turn the issues of object-oriented classes, mixins, self-reference and supertyping. The presentation is through a sequence of examples. This results in some overlap with that paper, but all the examples in the present paper are written entirely in Ada 83. I will return to considerations for Ada 9X in the last section of the paper.

  12. QUEST/Ada: Query utility environment for software testing of Ada

    Science.gov (United States)

    Brown, David B.

    1989-01-01

    Results of research and development efforts are presented for Task 1, Phase 2 of a general project entitled, The Development of a Program Analysis Environment for Ada. A prototype of the QUEST/Ada system was developed to collect data to determine the effectiveness of the rule-based testing paradigm. The prototype consists of five parts: the test data generator, the parser/scanner, the test coverage analyzer, a symbolic evaluator, and a data management facility, known as the Librarian. These components are discussed at length. Also presented is an experimental design for the evaluations, an overview of the project, and a schedule for its completion.

  13. Procedures and tools for building large Ada systems

    Science.gov (United States)

    Hyde, Ben

    1986-01-01

    Some of the problems unique to building a very large Ada system are addressed. This is done through examples from experience. In the winter of 1985 and 1986, Intermetrics bootstrapped the Ada compiler, which was being built over the last few years. This system consists of about one million lines of full Ada. Over the last few years a number of procedures and tools were adopted for managing the life cycle of each of the many parts of an Ada system. Many of these procedures are well known to most system builders: release management, quality assurance testing; and source file revision control. Others are unique to working in an Ada language environment; i.e., recompilation management, Ada program library management, and managing multiple implementations. First a look is taken at how a large Ada system is broken down into pieces. The Ada definition leaves unspecified a number of issues that the system builder must address: versions, subsystems, multiple implementations, and synchronization of branched development paths. Having introduced how the Ada systems are decomposed, a look is taken, via a series of examples, at how the life cylces of those parts is managed. The procedures and tools used to manage the evolution of the system are examined. It is hoped that other Ada system builders can build upon the experience of the last few years.

  14. Locus control regions

    National Research Council Canada - National Science Library

    Li, Qiliang; Peterson, Kenneth R; Fang, Xiangdong; Stamatoyannopoulos, George

    2002-01-01

    Locus control regions (LCRs) are operationally defined by their ability to enhance the expression of linked genes to physiological levels in a tissue-specific and copy number-dependent manner at ectopic chromatin sites...

  15. Association of G22A and A4223C ADA1 gene polymorphisms and ADA activity with PCOS.

    Science.gov (United States)

    Salehabadi, Mahshid; Farimani, Marzieh; Tavilani, Heidar; Ghorbani, Marzieh; Poormonsefi, Faranak; Poorolajal, Jalal; Shafiei, Gholamreza; Ghasemkhani, Neda; Khodadadi, Iraj

    2016-06-01

    Adenosine deaminase-1 (ADA1) regulates the concentration of adenosine as the main modulator of oocyte maturation. There is compelling evidence for the association of ADA1 gene polymorphisms with many diseases but the importance of ADA1 polymorphisms in polycystic ovary syndrome (PCOS) has not been studied before. This study investigates serum total ADA activity (tADA), ADA1 and ADA2 isoenzyme activities, and genotype and allele frequencies of G22A and A4223C polymorphisms in healthy and PCOS women. In this case-control study 200 PCOS patients and 200 healthy women were enrolled. Genomic DNA was extracted from whole blood and the PCR-RFLP technique was used to determine the G22A and A4223C variants. The genotype frequencies were calculated and the association between polymorphic genotypes and enzyme activities were determined. tADA activity was significantly lower in the PCOS group compared with the control group (27.76±6.0 vs. 39.63±7.48, respectively). PCOS patients also showed reduced activity of ADA1 and ADA2. PCOS was not associated with G22A polymorphism whereas AA, AC, and CC genotypes of A4223C polymorphism were found distributed differently between the control and the PCOS women where the C allele showed a strong protective role for PCOS (odds ratio=1.876, p=0.033). The present study for the first time showed that lower ADA activity may be involved in pathogenesis of PCOS by maintaining a higher concentration of adenosine affecting follicular growth. As a novel finding, we also showed great differences in genotype distribution and allele frequencies of A4223C polymorphism between groups indicating a protective role for C allele against PCOS. AbbreviationsADA: adenosine deaminase PCOS: polycystic ovary syndrome PCR-RFLP: polymerase chain reaction-restriction fragment length polymorphism tADA: total adenosine deaminase.

  16. ART/Ada design project, phase 1: Project plan

    Science.gov (United States)

    Allen, Bradley P.

    1988-01-01

    The plan and schedule for Phase 1 of the Ada based ESBT Design Research Project is described. The main platform for the project is a DEC Ada compiler on VAX mini-computers and VAXstations running the Virtual Memory System (VMS) operating system. The Ada effort and lines of code are given in tabular form. A chart is given of the entire project life cycle.

  17. LOCUS OF CONTROL, MOTIVASI BERPRESTASI DAN SIFAT JIWA WIRAUSAHA PADA MAHASISWA ITS

    Directory of Open Access Journals (Sweden)

    Sri Mulyono

    2009-11-01

    Full Text Available Karya McClelland tentang motif berprestasi (N-Ach sebagai suatu sifat wirausaha pokok telah mendorong berbagai bidang penelitian kewirausahaan. Selain motivasi berprestasi, karakteristik psikologis lain dari wirausahawan adalah Internal Locus of Control.Locus of Control adalah ciri pribadi yang sifatnya “ tergantung pada kekuatan dari dalam diri, dan karenanya bersifat menentukan nasib diri sendiri, berkeinginan kuat untuk independen dan otonom “.Tujuan penelitian ini untuk menguji dua sifat tersebut yaitu dengan mencari hubungan antara motivasi berprestasi dengan Locus of Control sebagai jiwa wirausaha. Selain itu ingin diketahui bagaimana profil awal pribadi sifat jiwa wirausaha yang dimiliki oleh mahasiswa ITS. Hasil penelitian menunjukkan angka korelasi (r angka .3741 dan dinyatakan signifikan dalam taraf signifikansi .01.Dengan demikian hipotesis yang menyatakan ada hubungan yang positif antara Locus of Control dan Motivasi Berprestasi dari mahasiswa ITS adalah diterima. Sedangkan profil keberadaan sifat jiwa wirausaha pada mahasiswa ITS adalah tergolong masih rendah dan cukup yaitu 39,2% mempunyai sifat jiwa wirausaha yang rendah dan 57,2% mempunyai sifat kewirausahaan yang cukup saja, dan hanya ada 3,6% saja yang tergolong mempunyai sifat jiwa kewirausahaan yang tergolong tinggi dan belum ada yang tergolong mempunyai sifat kewirausahaan yang sangat tinggi.Dari penelitian ini dapat diambil kesimpulan bahwa memang ada hubungan antara Locus of Control dengan motivasi berprestasi pada mahasiswa ITS, dan sifat jiwa kewirausahaan mahasiswa ITS masih tergolong kurang dan hanya cukup saja, maka dalam rangka menumbuhkan mentalitas kewirausahaan untuk menciptakan kerja sendiri maka perlu diciptakan iklim yang lebih mendukung untuk tercapainya tujuan perkuliahan kewirausahaan di ITS.

  18. Service dogs, psychiatric hospitalization, and the ADA.

    Science.gov (United States)

    Muramatsu, Russ S; Thomas, Kelly Jones; Leong, Stephanie L; Ragukonis, Frank

    2015-01-01

    A service dog is defined as "any dog that is individually trained to do work or perform tasks for the benefit of an individual with a disability, including a physical, sensory, psychiatric, intellectual, or other mental disability." Some psychiatric patients may depend on a service dog for day-to-day functioning. The Americans with Disabilities Act (ADA) established certain rights and responsibilities for individuals with disabilities and health care providers. Psychiatric hospitalization of a patient with a service dog may pose a problem and involves balancing the requirement to provide safe and appropriate psychiatric care with the rights of individuals with disabilities. This Open Forum examines issues that arise in such circumstances, reviews the literature, and provides a foundation for the development of policies and procedures.

  19. A design for a reusable Ada library

    Science.gov (United States)

    Litke, John D.

    1986-01-01

    A goal of the Ada language standardization effort is to promote reuse of software, implying the existence of substantial software libraries and the storage/retrieval mechanisms to support them. A searching/cataloging mechanism is proposed that permits full or partial distribution of the database, adapts to a variety of searching mechanisms, permits a changine taxonomy with minimal disruption, and minimizes the requirement of specialized cataloger/indexer skills. The important observation is that key words serve not only as indexing mechanism, but also as an identification mechanism, especially via concatenation and as support for a searching mechanism. By deliberately separating these multiple uses, the modifiability and ease of growth that current libraries require, is achieved.

  20. Alcohol Locus of Control.

    Science.gov (United States)

    Johnson, Patrick B.; Reszka, Diane

    Research has shown that differences in perceived control can influence drinking behavior and alcoholic rehabilitation. This study examined the viability of an alcohol-specific locus of control scale. Undergraduate students (41 male and 40 female) completed a demographic questionnaire assessing age, sex, ethnicity, and drinking frequency; Rotter's…

  1. First International Conference on Ada (R) Programming Language Applications for the NASA Space Station, volume 1

    Science.gov (United States)

    Bown, Rodney L. (Editor)

    1986-01-01

    Topics discussed include: test and verification; environment issues; distributed Ada issues; life cycle issues; Ada in Europe; management/training issues; common Ada interface set; and run time issues.

  2. ART/Ada design project, phase 1. Task 1 report: Overall design

    Science.gov (United States)

    Allen, Bradley P.

    1988-01-01

    The design methodology for the ART/Ada project is introduced, and the selected design for ART/Ada is described in detail. The following topics are included: object-oriented design, reusable software, documentation techniques, impact of Ada, design approach, and differences between ART-IM 1.5 and ART/Ada 1.0 prototype. Also, Ada generator and ART/Ada runtime systems are discussed.

  3. Software Engineering Laboratory (SEL) Ada performance study report

    Science.gov (United States)

    Booth, Eric W.; Stark, Michael E.

    1991-01-01

    The goals of the Ada Performance Study are described. The methods used are explained. Guidelines for future Ada development efforts are given. The goals and scope of the study are detailed, and the background of Ada development in the Flight Dynamics Division (FDD) is presented. The organization and overall purpose of each test are discussed. The purpose, methods, and results of each test and analyses of these results are given. Guidelines for future development efforts based on the analysis of results from this study are provided. The approach used on the performance tests is discussed.

  4. QUEST/Ada (Query Utility Environment for Software Testing of Ada): The development of a prgram analysis environment for Ada, task 1, phase 2

    Science.gov (United States)

    Brown, David B.

    1990-01-01

    The results of research and development efforts are described for Task one, Phase two of a general project entitled The Development of a Program Analysis Environment for Ada. The scope of this task includes the design and development of a prototype system for testing Ada software modules at the unit level. The system is called Query Utility Environment for Software Testing of Ada (QUEST/Ada). The prototype for condition coverage provides a platform that implements expert system interaction with program testing. The expert system can modify data in the instrument source code in order to achieve coverage goals. Given this initial prototype, it is possible to evaluate the rule base in order to develop improved rules for test case generation. The goals of Phase two are the following: (1) to continue to develop and improve the current user interface to support the other goals of this research effort (i.e., those related to improved testing efficiency and increased code reliable); (2) to develop and empirically evaluate a succession of alternative rule bases for the test case generator such that the expert system achieves coverage in a more efficient manner; and (3) to extend the concepts of the current test environment to address the issues of Ada concurrency.

  5. Latvian PR people are world class / Ada Parr

    Index Scriptorium Estoniae

    Parr, Ada

    2004-01-01

    Suhtekorraldusfirma Porter Novelli rahvusvahelise partnerluse juht suhtekorralduse osatähtsuse kasvust ettevõtete äritegevuses, suhtekorraldusturu olukorrast ja teenuste kvaliteedi tasemest Baltimaades. Vt. samas: Ada Parr recommends

  6. Adenosine-deaminase (ADA activity in Psoriasis (A Preliminary Study

    Directory of Open Access Journals (Sweden)

    S D Chaudhry

    1988-01-01

    Full Text Available Study of adenosine-deaminase activity ′in 23 patients hav-mg psoriasis compared with an equal number of healthy controls revealed significantly high ADA-activity in the psotiatic patients.

  7. A report on NASA software engineering and Ada training requirements

    Science.gov (United States)

    Legrand, Sue; Freedman, Glenn B.; Svabek, L.

    1987-01-01

    NASA's software engineering and Ada skill base are assessed and information that may result in new models for software engineering, Ada training plans, and curricula are provided. A quantitative assessment which reflects the requirements for software engineering and Ada training across NASA is provided. A recommended implementation plan including a suggested curriculum with associated duration per course and suggested means of delivery is also provided. The distinction between education and training is made. Although it was directed to focus on NASA's need for the latter, the key relationships to software engineering education are also identified. A rationale and strategy for implementing a life cycle education and training program are detailed in support of improved software engineering practices and the transition to Ada.

  8. The development of a program analysis environment for Ada

    Science.gov (United States)

    Brown, David B.; Carlisle, Homer W.; Chang, Kai-Hsiung; Cross, James H.; Deason, William H.; Haga, Kevin D.; Huggins, John R.; Keleher, William R. A.; Starke, Benjamin B.; Weyrich, Orville R.

    1989-01-01

    A unit level, Ada software module testing system, called Query Utility Environment for Software Testing of Ada (QUEST/Ada), is described. The project calls for the design and development of a prototype system. QUEST/Ada design began with a definition of the overall system structure and a description of component dependencies. The project team was divided into three groups to resolve the preliminary designs of the parser/scanner: the test data generator, and the test coverage analyzer. The Phase 1 report is a working document from which the system documentation will evolve. It provides history, a guide to report sections, a literature review, the definition of the system structure and high level interfaces, descriptions of the prototype scope, the three major components, and the plan for the remainder of the project. The appendices include specifications, statistics, two papers derived from the current research, a preliminary users' manual, and the proposal and work plan for Phase 2.

  9. Compiling knowledge-based systems specified in KEE to Ada

    Science.gov (United States)

    Filman, Robert E.; Feldman, Roy D.

    1991-01-01

    The first year of the PrKAda project is recounted. The primary goal was to develop a system for delivering Artificial Intelligence applications developed in the ProKappa system in a pure-Ada environment. The following areas are discussed: the ProKappa core and ProTalk programming language; the current status of the implementation; the limitations and restrictions of the current system; and the development of Ada-language message handlers in the ProKappa environment.

  10. Using Selected Features of Ada: A Collection of Papers.

    Science.gov (United States)

    1982-11-09

    Langauge Features by Dewayne Perry. .. .. .... ..... ... V Real Data Types in Ada by Brian Wichmann .. .. ... ..... ..... .. VI COPY FOREWORD This...proceed from first principles in this series. The present volume introduces the essential concepts of the application domain under consideration, and...application domain for which the Ada language was conceived, this class has been referred to as "embedded computer systems." Perhaps the primary

  11. An Independent Evaluation of the Declarative ADA Dialect

    Science.gov (United States)

    1994-01-01

    implementation. We believe it would have been better to have written the DAD language definition to say that a full implementation requires garbage...particular, both nested first class function definitions and exception handlers am translated into Ada code that does not compile correctly. In...pursue alternative approaches such as providing support for interlanguage calls between Ada and Smalltalk, ML or Miranda. The DAD software delivered by the

  12. Hydraulic Capacity of an ADA Compliant Street Drain Grate

    Energy Technology Data Exchange (ETDEWEB)

    Lottes, Steven A. [Argonne National Lab. (ANL), Argonne, IL (United States); Bojanowski, Cezary [Argonne National Lab. (ANL), Argonne, IL (United States)

    2015-09-01

    Resurfacing of urban roads with concurrent repairs and replacement of sections of curb and sidewalk may require pedestrian ramps that are compliant with the American Disabilities Act (ADA), and when street drains are in close proximity to the walkway, ADA compliant street grates may also be required. The Minnesota Department of Transportation ADA Operations Unit identified a foundry with an available grate that meets ADA requirements. Argonne National Laboratory’s Transportation Research and Analysis Computing Center used full scale three dimensional computational fluid dynamics to determine the performance of the ADA compliant grate and compared it to that of a standard vane grate. Analysis of a parametric set of cases was carried out, including variation in longitudinal, gutter, and cross street slopes and the water spread from the curb. The performance of the grates was characterized by the fraction of the total volume flow approaching the grate from the upstream that was captured by the grate and diverted into the catch basin. The fraction of the total flow entering over the grate from the side and the fraction of flow directly over a grate diverted into the catch basin were also quantities of interest that aid in understanding the differences in performance of the grates. The ADA compliant grate performance lagged that of the vane grate, increasingly so as upstream Reynolds number increased. The major factor leading to the performance difference between the two grates was the fraction of flow directly over the grates that is captured by the grates.

  13. Compiling knowledge-based systems from KEE to Ada

    Science.gov (United States)

    Filman, Robert E.; Bock, Conrad; Feldman, Roy

    1990-01-01

    The dominant technology for developing AI applications is to work in a multi-mechanism, integrated, knowledge-based system (KBS) development environment. Unfortunately, systems developed in such environments are inappropriate for delivering many applications - most importantly, they carry the baggage of the entire Lisp environment and are not written in conventional languages. One resolution of this problem would be to compile applications from complex environments to conventional languages. Here the first efforts to develop a system for compiling KBS developed in KEE to Ada (trademark). This system is called KATYDID, for KEE/Ada Translation Yields Development Into Delivery. KATYDID includes early prototypes of a run-time KEE core (object-structure) library module for Ada, and translation mechanisms for knowledge structures, rules, and Lisp code to Ada. Using these tools, part of a simple expert system was compiled (not quite automatically) to run in a purely Ada environment. This experience has given us various insights on Ada as an artificial intelligence programming language, potential solutions of some of the engineering difficulties encountered in early work, and inspiration on future system development.

  14. STUDY OF BCG SCAR AND SERUM ADA LEVELS IN INFANTS

    Directory of Open Access Journals (Sweden)

    Harishchandra Venkata Yanamandala

    2017-11-01

    Full Text Available BACKGROUND In developing countries, in both adults and children, tuberculosis is an important cause of morbidity and mortality. In 1993, it is declared as the first infectious disease by global health emergency.1 According to WHO report globally, there were an estimated 9.27 million ancient cases of TB in 2009. The cases reported were 8.3 million, the children covered an estimated percentage of 11 and it ranged from 3-25 percent.2 BCG vaccination was advocated for prevention of tuberculosis in children. The aim of the study is to estimate serum ADA levels in newborns before BCG vaccination, serum ADA levels in children with and without BCG scar, after receiving BCG vaccination, serum ADA levels in children without BCG vaccination and to find significance of serum ADA levels in BCG vaccinated children by comparing the above groups. MATERIALS AND METHODS This study was conducted at the Department of Paediatrics, Gitam Institute of Medical Sciences and Research Institute, October 2015 to September 2016. Babies who were in postnatal ward and infants of age of 12 weeks attending for BCG vaccination were included in the study. The total numbers of infants studied were 150. RESULTS In our study, out of 120 children included in the study before BCG vaccination comprising group-1, 61% were males and 39% were females. Out of 120 children received BCG vaccination, only 100 came for follow up comprising group-2, of which 67 (67% were males and 33 (33% were females. 15 children who did not receive BCG vaccination at 12 weeks of age were included in group 3 out of which 11 (73.33% were males and 4 (26.67% were females. Mean ADA levels at the age of 12 weeks in group-2 who were vaccinated at birth were 30.89 ± 5.27 U/L compared to mean ADA levels at the age of 12 weeks in group-3, which was 15.47 ± 1.85 U/L. This shows significant rise in mean ADA levels at 12 weeks of age in those who were vaccinated at birth comprising group-2 compared to their mean ADA

  15. ART/Ada design project, phase 1. Task 3 report: Test plan

    Science.gov (United States)

    Allen, Bradley P.

    1988-01-01

    The plan is described for the integrated testing and benchmark of Phase Ada based ESBT Design Research Project. The integration testing is divided into two phases: (1) the modules that do not rely on the Ada code generated by the Ada Generator are tested before the Ada Generator is implemented; and (2) all modules are integrated and tested with the Ada code generated by the Ada Generator. Its performance and size as well as its functionality is verified in this phase. The target platform is a DEC Ada compiler on VAX mini-computers and VAX stations running the VMS operating system.

  16. AdaNET phase 0 support for the AdaNET Dynamic Software Inventory (DSI) management system prototype. Catalog of available reusable software components

    Science.gov (United States)

    Hanley, Lionel

    1989-01-01

    The Ada Software Repository is a public-domain collection of Ada software and information. The Ada Software Repository is one of several repositories located on the SIMTEL20 Defense Data Network host computer at White Sands Missile Range, and available to any host computer on the network since 26 November 1984. This repository provides a free source for Ada programs and information. The Ada Software Repository is divided into several subdirectories. These directories are organized by topic, and their names and a brief overview of their topics are contained. The Ada Software Repository on SIMTEL20 serves two basic roles: to promote the exchange and use (reusability) of Ada programs and tools (including components) and to promote Ada education.

  17. ADA1 and NET1 Genes of Yeast Mediate Both Chromosome Maintenance and Mitochondrial $\\rho^{-}$ Mutagenesis

    CERN Document Server

    Koltovaya, N A; Tchekhouta, I A; Devin, A B

    2002-01-01

    An increase in the mitochondrial (mt) rho^- mutagenesis is a well-known respose of yeast cells to mutations in the numerous nuclear genes as well as to various kinds of stress. Notwithstanding the extensive studies during several decades the biological significance of this response is not yet fully understood. The genetic approach to solution of this subject includes the study of genes that are required for the high incidence of spontaneous rho^- mutants. Previously we found that mutations in certain nuclear genes including CDC28, the central cell-cycle regulation gene, may decrease the spontaneous rho^- mutability and simultaneously affect maintenance of the yeast chromosomes and plasmids. The present work provides data on identification of two more genes, resembling CDC28 in this respect. These genes NET1 and ADA1 mediate important regulatory protein-protein interactions in the yeast cell. The effects of net1 and ada1 mutations on the maintenance of yeast mt genome, chromosomes and plasmids as well as on ce...

  18. V Olimpíada Brasileira de Astronomia

    Science.gov (United States)

    Villas da Rocha, J. F.; Canalle, J. B. G.; Wuesnche, C. A.; de Medeiros, J. R., Silva, A. V. R.; Lavouras, D. F.; Dottori, H. A.; Maia, M. A. G.; Vieira Martins, R.; Poppe, P. C. R.

    2003-08-01

    Neste trabalho apresentamos os resultados da V Olimpíada Brasileira de Astronomia, a qual ocorreu em 11/05/2002 em todos os estabelecimentos de ensino fundamental ou médio previamente cadastrados. Participaram do evento 60.338 alunos distribuídos por 1469 escolas pertencentes a todos os Estados brasileiros. Uma equipe de 5 alunos foi escolhida para representar o Brasil na VII Olimpíada Internacional de Astronomia que ocorreu na Rússia em 2002 e dois de nossos alunos ganharam a medalha de bronze naquele evento.

  19. The Molecular Revolution in Cutaneous Biology: EDC and Locus Control.

    Science.gov (United States)

    Oh, Inez Y; de Guzman Strong, Cristina

    2017-05-01

    The epidermal differentiation complex (EDC) locus consists of a cluster of genes important for the terminal differentiation of the epidermis. While early studies identified the functional importance of individual EDC genes, the recognition of the EDC genes as a cluster with its shared biology, homology, and physical linkage was pivotal to later studies that investigated the transcriptional regulation of the locus. Evolutionary conservation of the EDC and the transcriptional activation during epidermal differentiation suggested a cis-regulatory mechanism via conserved noncoding elements or enhancers. This line of pursuit led to the identification of CNE 923, an epidermal-specific enhancer that was found to mediate chromatin remodeling of the EDC in an AP-1 dependent manner. These genomic studies, as well as the advent of high-throughput sequencing and genome engineering techniques, have paved the way for future investigation into enhancer-mediated regulatory networks in cutaneous biology. Copyright © 2016 The Authors. Published by Elsevier Inc. All rights reserved.

  20. Surfeit locus gene homologs are widely distributed in invertebrate genomes.

    OpenAIRE

    Armes, N.; Fried, M.

    1996-01-01

    The mouse Surfeit locus contains six sequence-unrelated genes (Surf-1 to -6) arranged in the tightest gene cluster so far described for mammals. The organization and juxtaposition of five of the Surfeit genes (Surf-1 to -5) are conserved between mammals and birds, and this may reflect a functional or regulatory requirement for the gene clustering. We have undertaken an evolutionary study to determine whether the Surfeit genes are conserved and clustered in invertebrate genomes. Drosophila mel...

  1. Transcriptional analysis of the Streptococcus pyogenes salivaricin locus.

    Science.gov (United States)

    Namprachan-Frantz, Phanramphoei; Rowe, Hannah M; Runft, Donna L; Neely, Melody N

    2014-02-01

    The sal lantibiotic locus plays an important role in the virulence of Streptococcus pyogenes. Our transcriptional analysis of the sal locus provides new information on the complex regulation of this operon. Transcription of the operon is regulated by a promoter upstream of the operon and by a second internal promoter upstream of the salKRZ genes. Here we identify the location of the internal promoter and provide information on how this promoter is autoregulated by proteins within the locus. We determined by primer extension that the salKR promoter is located within the salY gene and identified several regulatory regions important for expression. The higher activity of the promoter in a salKR deletion strain indicates a role in repression by the SalR response regulator. Further, this promoter had higher activity in a salA deletion strain, implicating corepression or a signaling role for the SalA peptide. Finally, we demonstrate that this promoter can be controlled by host factors. Analysis of transcriptional regulation of this locus provides a better understanding of the function of the sal locus in S. pyogenes pathogenesis.

  2. Regulatory agencies and regulatory risk

    OpenAIRE

    Knieps, Günter; Weiß, Hans-Jörg

    2008-01-01

    The aim of this paper is to show that regulatory risk is due to the discretionary behaviour of regulatory agencies, caused by a too extensive regulatory mandate provided by the legislator. The normative point of reference and a behavioural model of regulatory agencies based on the positive theory of regulation are presented. Regulatory risk with regard to the future behaviour of regulatory agencies is modelled as the consequence of the ex ante uncertainty about the relative influence of inter...

  3. Locus of control and competence.

    Science.gov (United States)

    Naditch, M P; DeMaio, T

    1975-12-01

    The relation of locus of control and competence in school achievement, social interactions, sports, and home related activities was examined. The sample consisted of 346 ninth-grade students, and competence was measured using self-report, antional battery test scores, grades, and sociometric ratings. Among males, locus of control was significantly related to competent performance only among those subjects who placed a high value on outcomes in each area. Among females, the pattern was exactly reversed. Locus of control and various forms of competence were related only in areas of low interest value. The implications of these findings were discussed.

  4. Adenosine Deaminase, (ADA) level in leprosy | Ogbu | International ...

    African Journals Online (AJOL)

    Background: Adenosine deaminase (ADA) is involved in and the catabolism of toxic de-oxynucleotides (5) and modulation of insulin action. Although its activities in leprosy have been measured, its characteristics have not been reported. Objective: To determine adenosine deaminase activities in leprosy and possible ...

  5. Molecular Characterization Of The Vernalization Locus VRN1 In Perennial Ryegrass

    DEFF Research Database (Denmark)

    Asp, Torben; Byrne, Stephen; Andersen, Jeppe R

    in perennial ryegrass (Lolium perenne). Two allelic BAC clones of the VRN1 locus from the two genotypes Veyo and Falster with contrasting vernalization requirements were identified, sequenced, and characterized. The region surrounding the VRN1 locus in perennial ryegrass showed micro...... vernalization requirement. Our findings suggest that the 8.6kb region in the first intron of the VRN1 gene is an important regulatory region for vernalization response in perennial ryegrass....

  6. 76 FR 38129 - Applications for New Awards; Americans With Disabilities Act (ADA) National Network Knowledge...

    Science.gov (United States)

    2011-06-29

    ... Applications for New Awards; Americans With Disabilities Act (ADA) National Network Knowledge Translation... Rehabilitation Research Projects (DRRP)--The ADA National Network Knowledge Translation Center Notice inviting..., demonstration, development, dissemination, utilization, and technical assistance. An applicant for assistance...

  7. Pobreza y Locus de Control

    Directory of Open Access Journals (Sweden)

    Joaquina Palomar Lever

    2004-01-01

    Full Text Available En este trabajo se busco conocer si existen diferencias en el locus de control según el nivel de pobreza en una población de 900 personas clasificadas en tres grupos: pobres extremos, pobres moderados y no pobres. Los sujetos estudiados compartieron la característica de ser personas económicamente independientes. Para este estudio se utilizaron como instrumentos de medición, un cuestionario sociodemográfico y una escala de locus de control. Los resultados muestran que los grupos de mayor ingreso familiar así como el grupo de no pobres y el de pobres moderados presentan en mayor medida un locus de control interno, mientras que el grupo de pobres extremos un mayor locus de control externo; por otro lado se observó que las personas de sexo masculino así como los de más edad (36 a 72 años presentan un locus de control más interno que aquellas personas de sexo femenino y de menor edad (19 a 35 años. Además, las personas con mayor nivel educativo (licenciatura y postgrado presentan una mayor tendencia hacia la internalidad en comparación con las personas de menor nivel educativo (sin escolaridad, primaria, secundaria y preparatoria. A su vez, se observó que la escolaridad de los padres influye en el locus de control. En términos generales, las variables que mejor predicen el locus de control fueron el ingreso familiar y la escolaridad de los sujetos

  8. Formal verification and testing: An integrated approach to validating Ada programs

    Science.gov (United States)

    Cohen, Norman H.

    1986-01-01

    An integrated set of tools called a validation environment is proposed to support the validation of Ada programs by a combination of methods. A Modular Ada Validation Environment (MAVEN) is described which proposes a context in which formal verification can fit into the industrial development of Ada software.

  9. Evolution of Ada technology in the flight dynamics area: Design phase analysis

    Science.gov (United States)

    Quimby, Kelvin L.; Esker, Linda

    1988-01-01

    The software engineering issues related to the use of the Ada programming language during the design phase of an Ada project are analyzed. Discussion shows how an evolving understanding of these issues is reflected in the design processes of three generations of Ada projects.

  10. Evolution of Ada technology in the flight dynamics area: Implementation/testing phase analysis

    Science.gov (United States)

    Quimby, Kelvin L.; Esker, Linda; Miller, John; Smith, Laurie; Stark, Mike; Mcgarry, Frank

    1989-01-01

    An analysis is presented of the software engineering issues related to the use of Ada for the implementation and system testing phases of four Ada projects developed in the flight dynamics area. These projects reflect an evolving understanding of more effective use of Ada features. In addition, the testing methodology used on these projects has changed substantially from that used on previous FORTRAN projects.

  11. Ada Compiler Validation Summary Report. Certificate Number. 88032211. 09047, Tartan Laboratories Incorporated Tartan Ada VMS/VMS, Version 2.OV, MicroVax II

    Science.gov (United States)

    1988-03-20

    subject compiler has no nonconformities to the Ada Standard other than those presented. Copies of this report are available to the public from: Ada...translators, and interpreters. Failed test An ACVC test for which the compiler generates a result that demonstrates nonconformity to the Ada Standard. Host The...inapplicable for the reasons indicated: E28002D and E28005D use pragmas LIST and PAGE which are ignored by this compiler. This behaviour was ruled

  12. Ada Compiler Validation Summary Report: Proprietary Software Systems, Inc., PSS Ada Compiler VAX/VMS, VAX/VMS 8350 (Host and Target) 89071011.10120

    Science.gov (United States)

    1989-07-10

    compiler has no nonconformities to the Ada Standard other than those presented. Copies of this report are available to the public from: Ada Information...result that demonstrates nonconformity to the Ada Standard. Host The computer on which the compiler resides. Inapplicable An ACVC test that uses features...units are in separate compilation files or not. A1408 and AI506 allow this behaviour . 1) Generic specifications and bodies can be compiled in separate

  13. Distributed Issues for Ada Real-Time Systems

    Science.gov (United States)

    1990-07-23

    distribution of a single Ada program over a network of three Intel 80386 processors connected by an Ethernet. The results of the benchmarks were...Operator Interface (peak data rate of 500Hz) - Using current technology: 32-bit Microprocessors ( 80386 -16MHz) I - Initially a separate program was designated...controlling) CPU and which arc the Slaves. The Master is distinguished from the Slaves in that it is responsible for the distributed system Configuration

  14. Overfitting Reduction of Text Classification Based on AdaBELM

    OpenAIRE

    Xiaoyue Feng; Yanchun Liang; Xiaohu Shi; Dong Xu; Xu Wang; Renchu Guan

    2017-01-01

    Overfitting is an important problem in machine learning. Several algorithms, such as the extreme learning machine (ELM), suffer from this issue when facing high-dimensional sparse data, e.g., in text classification. One common issue is that the extent of overfitting is not well quantified. In this paper, we propose a quantitative measure of overfitting referred to as the rate of overfitting (RO) and a novel model, named AdaBELM, to reduce the overfitting. With RO, the overfitting problem can ...

  15. Survey of Ada (Trademark)-Based PDLs (Program Design Language).

    Science.gov (United States)

    1985-01-01

    documentation consists of a single reference manual. In order to support the use of the PDL in a multi- lingual environment, the manual provides...Contact: Timothy Porter Tel: 619-293-7500 PDL Identification: Sanders Ada/PDL Organization: Sanders Associates, Inc. Federal Systems Group 95 Canal ...M. Blasewitz Tel: 609-541-7000 Organization: Sanders Associates, Inc. Federal Systems Group 95 Canal Street Nashua, NH 03061 PDL Identification

  16. AN ADA LINEAR ALGEBRA PACKAGE MODELED AFTER HAL/S

    Science.gov (United States)

    Klumpp, A. R.

    1994-01-01

    This package extends the Ada programming language to include linear algebra capabilities similar to those of the HAL/S programming language. The package is designed for avionics applications such as Space Station flight software. In addition to the HAL/S built-in functions, the package incorporates the quaternion functions used in the Shuttle and Galileo projects, and routines from LINPAK that solve systems of equations involving general square matrices. Language conventions in this package follow those of HAL/S to the maximum extent practical and minimize the effort required for writing new avionics software and translating existent software into Ada. Valid numeric types in this package include scalar, vector, matrix, and quaternion declarations. (Quaternions are fourcomponent vectors used in representing motion between two coordinate frames). Single precision and double precision floating point arithmetic is available in addition to the standard double precision integer manipulation. Infix operators are used instead of function calls to define dot products, cross products, quaternion products, and mixed scalar-vector, scalar-matrix, and vector-matrix products. The package contains two generic programs: one for floating point, and one for integer. The actual component type is passed as a formal parameter to the generic linear algebra package. The procedures for solving systems of linear equations defined by general matrices include GEFA, GECO, GESL, and GIDI. The HAL/S functions include ABVAL, UNIT, TRACE, DET, INVERSE, TRANSPOSE, GET, PUT, FETCH, PLACE, and IDENTITY. This package is written in Ada (Version 1.2) for batch execution and is machine independent. The linear algebra software depends on nothing outside the Ada language except for a call to a square root function for floating point scalars (such as SQRT in the DEC VAX MATHLIB library). This program was developed in 1989, and is a copyrighted work with all copyright vested in NASA.

  17. Olimpíadas e geopolítica

    Directory of Open Access Journals (Sweden)

    João Fábio Bertonha

    2008-09-01

    Full Text Available

    o artigo trata de competições esportivas,

    em especial as olimpíadas. Nelas, valorizam-se o

    nacionalismo e o poder dos países.

  18. ADA perceived disability claims: a decision-tree analysis.

    Science.gov (United States)

    Draper, William R; Hawley, Carolyn E; McMahon, Brian T; Reid, Christine A; Barbir, Lara A

    2014-06-01

    The purpose of this study is to examine the possible interactions of predictor variables pertaining to perceived disability claims contained in a large governmental database. Specifically, it is a retrospective analysis of US Equal Employment Opportunity Commission (EEOC) data for the entire population of workplace discrimination claims based on the "regarded as disabled" prong of the Americans with Disabilities Act (ADA) definition of disability. The study utilized records extracted from a "master database" of over two million charges of workplace discrimination in the Integrated Mission System of the EEOC. This database includes all ADA-related discrimination allegations filed from July 26, 1992 through December 31, 2008. Chi squared automatic interaction detection (CHAID) was employed to analyze interaction effects of relevant variables, such as issue (grievance) and industry type. The research question addressed by CHAID is: What combination of factors are associated with merit outcomes for people making ADA EEOC allegations who are "regarded as" having disabilities? The CHAID analysis shows how merit outcome is predicted by the interaction of relevant variables. Issue was found to be the most prominent variable in determining merit outcome, followed by industry type, but the picture is made more complex by qualifications regarding age and race data. Although discharge was the most frequent grievance among charging parties in the perceived disability group, its merit outcome was significantly less than that for the leading factor of hiring.

  19. Overfitting Reduction of Text Classification Based on AdaBELM

    Directory of Open Access Journals (Sweden)

    Xiaoyue Feng

    2017-07-01

    Full Text Available Overfitting is an important problem in machine learning. Several algorithms, such as the extreme learning machine (ELM, suffer from this issue when facing high-dimensional sparse data, e.g., in text classification. One common issue is that the extent of overfitting is not well quantified. In this paper, we propose a quantitative measure of overfitting referred to as the rate of overfitting (RO and a novel model, named AdaBELM, to reduce the overfitting. With RO, the overfitting problem can be quantitatively measured and identified. The newly proposed model can achieve high performance on multi-class text classification. To evaluate the generalizability of the new model, we designed experiments based on three datasets, i.e., the 20 Newsgroups, Reuters-21578, and BioMed corpora, which represent balanced, unbalanced, and real application data, respectively. Experiment results demonstrate that AdaBELM can reduce overfitting and outperform classical ELM, decision tree, random forests, and AdaBoost on all three text-classification datasets; for example, it can achieve 62.2% higher accuracy than ELM. Therefore, the proposed model has a good generalizability.

  20. Software tools to aid Pascal and Ada program design

    Energy Technology Data Exchange (ETDEWEB)

    Jankowitz, H.T.

    1987-01-01

    This thesis describes a software tool which analyses the style and structure of Pascal and Ada programs by ensuring that some minimum design requirements are fulfilled. The tool is used in much the same way as a compiler is used to teach students the syntax of a language, only in this case issues related to the design and structure of the program are of paramount importance. The tool operates by analyzing the design and structure of a syntactically correct program, automatically generating a report detailing changes that need to be made in order to ensure that the program is structurally sound. The author discusses how the model gradually evolved from a plagiarism detection system which extracted several measurable characteristics in a program to a model that analyzed the style of Pascal programs. In order to incorporate more-sophistical concepts like data abstraction, information hiding and data protection, this model was then extended to analyze the composition of Ada programs. The Ada model takes full advantage of facilities offered in the language and by using this tool the standard and quality of written programs is raised whilst the fundamental principles of program design are grasped through a process of self-tuition.

  1. Pobreza y Locus de Control

    OpenAIRE

    Joaquina Palomar Lever; Laura M. Valdés Trejo

    2004-01-01

    En este trabajo se busco conocer si existen diferencias en el locus de control según el nivel de pobreza en una población de 900 personas clasificadas en tres grupos: pobres extremos, pobres moderados y no pobres. Los sujetos estudiados compartieron la característica de ser personas económicamente independientes. Para este estudio se utilizaron como instrumentos de medición, un cuestionario sociodemográfico y una escala de locus de control. Los resultados muestran que los grupos d...

  2. Ada Compiler Validation Summary Report: Certificate Number: 920509S1. 11259 Alenia Aeritalia and Selenia S.p.A DACS VAX/VMS to 80x86 PM MARA Ada Cross Compiler, Version 4.6 Microvax 4000/200 => MARA

    Science.gov (United States)

    1992-01-01

    handling associated to any process which implements an ADA task. It is activated whenever there is an exception, whether it is Ada or is not Ada. codice ...INTERFACE exc. non ADA ------- v codice ADA exception ADA AH A AI .1 I sistema operativo exc. non ADA ------- - fig. 1- Function Exception Handling is

  3. A biotin-drug extraction and acid dissociation (BEAD) procedure to eliminate matrix and drug interference in a protein complex anti-drug antibody (ADA) isotype specific assay.

    Science.gov (United States)

    Niu, Hongmei; Klem, Thomas; Yang, Jinsong; Qiu, Yongchang; Pan, Luying

    2017-07-01

    Monitoring anti-drug antibody (ADA) responses in patients receiving protein therapeutics treatment is an important safety assessment for regulatory agencies, drug manufacturers, clinicians and patients. Recombinant human IGF-1/IGFBP-3 (rhIGF-1/rhIGFBP-3) is a 1:1 formulation of naturally occurring protein complex. The individual IGF-1 and IGFBP-3 proteins have multiple binding partners in serum matrix with high binding affinity to each other, which presents challenges in ADA assay development. We have developed a biotin-drug extraction with acid dissociation (BEAD) procedure followed by an electrochemiluminescence (ECL) direct assay to overcome matrix and drug interference. The method utilizes two step acid dissociation and excess biotin-drug to extract total ADA, which are further captured by soluble biotin-drug and detected in an ECL semi-homogeneous direct assay format. The pre-treatment method effectively eliminates interference by serum matrix and free drug, and enhances assay sensitivity. The assays passed acceptance criteria for all validation parameters, and have been used for clinical sample Ab testing. This method principle exemplifies a new approach for anti-isotype ADA assays, and could be an effective strategy for neutralizing antibody (NAb), pharmacokinetic (PK) and biomarker analysis in need of overcoming interference factors. Copyright © 2017 Elsevier B.V. All rights reserved.

  4. Locus of control in graduation students

    OpenAIRE

    Haider Zaidi, Imran; MS (Clinical Psychology) Scholar G.C University, Faisalabad, Pakistan; Mohsin, M. Naeem; Director Distance Learning Education G.C University, Faisalabad, Pakistan

    2013-01-01

    The current research focused on exploring the direction of Locus of control as well as gender difference on locus of control among graduation students in Pakistan. A 29 item Locus of Control questionnaire (Rotter, 1966) was used to measure locus of control. Sample of (N=200) individuals (n=100) men and (n=100) women selected from different academic institutes of Faisalabad division Punjab Pakistan. Independent sample t-test was used for statistical analysis. This study has consistent results ...

  5. A non-sense mutation in the putative anti-mutator gene ada/alkA of Mycobacterium tuberculosis and M. bovis isolates suggests convergent evolution

    Directory of Open Access Journals (Sweden)

    Gicquel Brigitte

    2007-05-01

    Full Text Available Abstract Background Previous studies have suggested that variations in DNA repair genes of W-Beijing strains may have led to transient mutator phenotypes which in turn may have contributed to host adaptation of this strain family. Single nucleotide polymorphism (SNP in the DNA repair gene mutT1 was identified in MDR-prone strains from the Central African Republic. A Mycobacteriumtuberculosis H37Rv mutant inactivated in two DNA repair genes, namely ada/alkA and ogt, was shown to display a hypermutator phenotype. We then looked for polymorphisms in these genes in Central African Republic strains (CAR. Results In this study, 55 MDR and 194 non-MDR strains were analyzed. Variations in DNA repair genes ada/alkA and ogt were identified. Among them, by comparison to M. tuberculosis published sequences, we found a non-sense variation in ada/alkA gene which was also observed in M. bovis AF2122 strain. SNPs that are present in the adjacent regions to the amber variation are different in M. bovis and in M. tuberculosis strain. Conclusion An Amber codon was found in the ada/alkA locus of clustered M. tuberculosis isolates and in M. bovis strain AF2122. This is likely due to convergent evolution because SNP differences between strains are incompatible with horizontal transfer of an entire gene. This suggests that such a variation may confer a selective advantage and be implicated in hypermutator phenotype expression, which in turn contributes to adaptation to environmental changes.

  6. Airborne pollen content of Kuşadası

    OpenAIRE

    TOSUNOĞLU, Aycan; YENİGÜN, Ayşe; BIÇAKÇI, Adem; ELİAÇIK, Kayı

    2013-01-01

    Atmospheric pollen grains of Kuşadası were captured using Durham samplers and investigated in 2005. The total number of pollen grains and the pollen grains/cm2 were calculated from slides that were changed weekly. During the study period a total of 12,980 pollen grains/cm2 belonging to 44 identified taxa and unidentified pollen grains were recorded at 2 stations. At the first station (S1), 7346 pollen grains were counted per cm2, while only 5634 pollen grains were counted at the second statio...

  7. Large distributed control system using ADA in fusion research

    Energy Technology Data Exchange (ETDEWEB)

    Woodruff, J. P., LLNL

    1998-04-21

    Construction of the National Ignition Facility laser at Lawrence Livermore National Laboratory features a large distributed control system constructed using object-oriented software engineering techniques. Control of 60,000 devices is effected using a network of some 500 computers that run software written in Ada and communicating through CORBA. The project has completed its final design review; implementation of the first of five planned increments will be delivered at the end of fiscal year 1998. Preliminary measures of the distributed controls performance confirm the design decisions reported in this paper, and the measurement and supporting simulation of full system performance continue.

  8. Beyond ADA Accessibility Requirements: Meeting Seniors' Needs for Toilet Transfers.

    Science.gov (United States)

    Lee, Su Jin; Sanford, Jon; Calkins, Margaret; Melgen, Sarah; Endicott, Sarah; Phillips, Anjanette

    2017-01-01

    To identify the optimal spatial and dimensional requirements of grab bars that support independent and assisted transfers by older adults and their care providers. Although research has demonstrated that toilet grab bars based on the Americans with Disabilities Act (ADA) Accessibility Standards do not meet the needs of older adults, the specific dimensional requirements for alternative configurations are unknown. A two-phased study with older adults and care providers in residential facilities was conducted to determine the optimal requirements for grab bars. Seniors and caregivers in skilled nursing facilities performed transfers using a mock-up toilet. In Phase 1, participants evaluated three grab bar configurations to identify optimal characteristics for safety, ease of use, comfort, and helpfulness. These characteristics were then validated for using ability-matched samples in Phase 2. The optimal configuration derived in Phase 1 included fold-down grab bars on both sides of the toilet (14" from centerline [CL] of toilet, 32" above the floor, and extended a minimum of 6" in front of the toilet) with one side open and a sidewall 24" from CL of toilet on the other. Phase 2 feedback was significantly positive for independent and one-person transfers and somewhat lower, albeit still positive, for two-person transfers. The study provides substantial evidence that bilateral grab bars are significantly more effective than those that comply with current ADA Accessibility Standards. Findings provide specific spatial and dimensional attributes for grab bar configurations that would be most effective in senior facilities.

  9. Efficient Ada multitasking on a RISC register window architecture

    Science.gov (United States)

    Kearns, J. P.; Quammen, D.

    1987-01-01

    This work addresses the problem of reducing context switch overhead on a processor which supports a large register file - a register file much like that which is part of the Berkeley RISC processors and several other emerging architectures (which are not necessarily reduced instruction set machines in the purest sense). Such a reduction in overhead is particularly desirable in a real-time embedded application, in which task-to-task context switch overhead may result in failure to meet crucial deadlines. A storage management technique by which a context switch may be implemented as cheaply as a procedure call is presented. The essence of this technique is the avoidance of the save/restore of registers on the context switch. This is achieved through analysis of the static source text of an Ada tasking program. Information gained during that analysis directs the optimized storage management strategy for that program at run time. A formal verification of the technique in terms of an operational control model and an evaluation of the technique's performance via simulations driven by synthetic Ada program traces are presented.

  10. A new method for solving overfitting problem of gentle AdaBoost

    Science.gov (United States)

    Wu, Shuqiong; Nagahashi, Hiroshi

    2014-01-01

    AdaBoost is a machine learning technique which integrates many weak classifiers into one strong classifier to enhance its classification performance. Gentle AdaBoost is a variant of AdaBoost which introduces Newton steps to the boosting process. It is proved that the overall performance considering both the training error and generalization error of Gentle AdaBoost is better than other AdaBoost variants on low-noise data. However, it suffers from overfitting problem when the training data include high noise. To solve this problem, we propose a new approach to limit the weight distortion according to a stretched distribution of the whole sample weights. Experimental results have shown that our algorithm obtains a better generalization error on both standard and noise-input datasets. Moreover, our method does not increase the calculation time compared with Gentle AdaBoost.

  11. How the FDA and the ADA affect development of prescription drugs for oral care.

    Science.gov (United States)

    Cooley, W E

    1992-01-01

    The patient-consumer, the health professional, and the producer are all essential in the world of prescription drugs for oral care. Also essential are the Food and Drug Administration (FDA) and the American Dental Association (ADA). The FDA is charged with reviewing new-drug applications in the United States and approving those drugs that are proved safe and effective. The FDA also controls prescription-drug advertising and promotion. The ADA applies professional standards in judging all submitted dental drugs. Those drugs accepted by ADA's Council on Dental Therapeutics may display the ADA seal in labeling and advertising. All advertising for accepted products must be cleared by the ADA. An example of a prescription drug approved by the FDA and accepted by the ADA is 0.12 percent chlorhexidine gluconate oral rinse (Peridex). This drug followed the FDA's investigational-drug (IND) regulations before final approval as a treatment for gingivitis.

  12. Speaking rate effects on locus equation slope

    Science.gov (United States)

    Berry, Jeff; Weismer, Gary

    2013-01-01

    A locus equation describes a 1st order regression fit to a scatter of vowel steady-state frequency values predicting vowel onset frequency values. Locus equation coefficients are often interpreted as indices of coarticulation. Speaking rate variations with a constant consonant–vowel form are thought to induce changes in the degree of coarticulation. In the current work, the hypothesis that locus slope is a transparent index of coarticulation is examined through the analysis of acoustic samples of large-scale, nearly continuous variations in speaking rate. Following the methodological conventions for locus equation derivation, data pooled across ten vowels yield locus equation slopes that are mostly consistent with the hypothesis that locus equations vary systematically with coarticulation. Comparable analyses between different four-vowel pools reveal variations in the locus slope range and changes in locus slope sensitivity to rate change. Analyses across rate but within vowels are substantially less consistent with the locus hypothesis. Taken together, these findings suggest that the practice of vowel pooling exerts a non-negligible influence on locus outcomes. Results are discussed within the context of articulatory accounts of locus equations and the effects of speaking rate change. PMID:24535890

  13. PENGARUH PENGALAMAN PRAKTIK KERJA INDUSTRI, MOTIVASI BERORGANISASI, DAN LOCUS OF CONTROL TERHADAP SOFT SKILLS SISWA SMK

    Directory of Open Access Journals (Sweden)

    Silfia Pendri Nuryanti

    2016-02-01

    Full Text Available Tujuan dari penelitian ini yaitu untuk mengetahui adakah pengaruh pengalaman praktik kerja industri, motivasi berorganisassi dan locus of control terhadap soft skills siswa kelas XI di SMK PGRI 01 Semarang secara siimultan maupun parsial. Populasi dalam penelitian ini adalah seluruh siswa kelas XI di SMK PGRI 01 Semarang yang berjumlah 125 siswa dan sampel dalam penelitian ini adalah seluruh populasi yang berjumlah 125 siswa. Teknik analisis data menggunakan analisis deskriptif persentase dan analisis regresi berganda. Hasil dari regresi ganda penelitian ini yaitu .. Ada pengaruh secara simultan sebesar 33,7%, sedangkan pengaruh secara parsial pengalaman praktik kerja industri sebesar 12,25%, motivasi berorganisasi sebesar 4,04% dan locus of control sebesar 4,7%. Kesimpulan penelitian ini yaitu ada pengaruh antara pengalaman praktik kerja industri, motivasi beroganisasi dan locus of control secara simultan maupun parsial. Saran dalam penelitian yaitu untuk siswa sebaiknya memanfaatkan kegiatan yang diberikan oleh sekolah dalam kegiatan praktik kerja industri dan ektrakurikuler dengan semaksimal mungkin dan kepada pihak sekolah untuk dapat pengembangan soft skills pada kegiatan ektrakurikuler diharapkan adanya reward atau penghargaan berupa tambahan mengenai penilaian yang diberikan kepada siswa sehingga siswa lebih termotivasi dalam kegiatan ektrakurikuler. This research has purpose to find out the presence of effects of industrial practice work, organizational motivation and locus of control toward the soft skills of grade XI students in SMK PGRI 01 Semarang simultaneously or partially.The population of the research is grade XI in SMK PGRI 01 Semarang and Sample in this research, which is the entire population 125 students. The data collected using questionnaire and documentations. The analyzing method used percentage descriptive analysis and double regression analysis.The result of double linier regression analysis in this research are

  14. A two-locus model of speciation.

    Science.gov (United States)

    Gregorius, H R

    1992-02-07

    Speciation is considered as the evolution of partial or complete cross-incompatibility between the carriers of genes (at a locus called "object locus") that distinguish the prospective species populations. The mating relations at the object locus are modified by the alleles at a second mating modifier locus. Based on a widely applicable concept of fitness and mating preference, it is shown that heterozygote disadvantage in fitness at the object locus is necessary for speciation, which corroborates Wallace's hypothesis. It is pointed out that the difference between sympatric and parapatric speciation essentially lies in the mechanisms stabilizing the polymorphism required at the object locus as a prerequisite for speciation. In the presence of recombination between the object and mating modifier locus speciation may be prevented by forces maintaining gametic phase imbalance between these loci such as can result from unidirectional gene flow between parapatric populations.

  15. ADA Implementation Issues as Discovered through a Literature Survey of Applications Outside the United States

    Science.gov (United States)

    1992-03-01

    Ada market, available at significant cost. (Focused Ada Research, 1991; Software Strategy & Tactics, 1991) They divide Ada usage into specific...from its aptitude for use with embedded systems to marketing strategy reasons. These 34 were discussed in Chapter II as language advantages. Although...Finnish bank being developed by Nokia • Oil drilling control system managed by Sedco- Forex * Vigile - an industrial installation supervisor project by

  16. TCP-ADaLR: TCP with adaptive delay and loss response for broadband GEO satellite networks

    OpenAIRE

    Omueti, Modupe Omogbohun

    2007-01-01

    Transmission Control Protocol (TCP) performance degrades in broadband geostationary satellite networks due to long propagation delays and high bit error rates. In this thesis, we propose TCP with algorithm modifications for adaptive delay and loss response (TCP-ADaLR) to improve TCP performance. TCP-ADaLR incorporates delayed acknowledgement mechanism recommended for Internet hosts. We evaluate and compare the performance of TCP-ADaLR, TCP SACK, and TCP NewReno, with and without delayed ackno...

  17. Ada Compiler Validation Summary Report: Proprietary Software Systems, Inc., PSS VAX.1750A Ada Compiler, VAX 8350 (Host) to MIL-STD-1750A/PSS AdaRAID (Target)

    Science.gov (United States)

    1989-12-18

    set forth in this report are accurate and complete, or that the subject compiler has no nonconformities to the Ada Standard other than those presented...translators, and interpreters. Failed test An ACVC test for which the compiler generates a result that demonstrates nonconformity to the Ada Standard. Host The...units are in separate compilation files or not. A1408 and A1506 allow this behaviour . 1) Generic specifications and bodies can be compiled in separate

  18. Do published ADA studies support the ADA-EASD position statement for the management of hyperglycaemia in type 2 diabetics?

    Science.gov (United States)

    Rimareix, Frédérique; Bauduceau, Bernard

    2013-07-01

    The American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) published a position statement in 2012 on the management of hyperglycaemia in patients with type 2 diabetes. The Société Francophone du Diabète (SFD) adopted it while awaiting future French recommendations. This new care approach individualises the therapeutic choices and objectives for each patient based on their characteristics, through emphasis on the need for mutual cooperation with the patient in decision-making. Glycaemic management should naturally be considered in the context of overall cardiovascular risk reduction, which should remain the primary objective of treatment. The cornerstone of this treatment is based on lifestyle modifications, with the addition of metformin monotherapy if the desired glycaemic control is not attained. There are multiple second- and third-line treatment possibilities, and insulin therapy is an option that can be considered early in the bitherapy stage. On the whole, large published studies at the ADA conference in Philadelphia in June 2012, which are the subject of this article, support this patient-centred position statement. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  19. ART/Ada design project, phase 1. Task 2 report: Detailed design

    Science.gov (United States)

    Allen, Bradley P.

    1988-01-01

    Various issues are studied in the context of the design of an Ada based expert system building tool. Using an existing successful design as a starting point, the impact is analyzed of the Ada language and Ada development methodologies on that design, the Ada system is redesigned, and its performance is analyzed using both complexity-theoretic and empirical techniques. The algorithms specified in the overall design are refined, resolving and documenting any open design issues, identifying each system module, documenting the internal architecture and control logic, and describing the primary data structures involved in the module.

  20. ADA3 regulates normal and tumor mammary epithelial cell proliferation through c-MYC.

    Science.gov (United States)

    Griffin, Nicolas I; Sharma, Gayatri; Zhao, Xiangshan; Mirza, Sameer; Srivastava, Shashank; Dave, Bhavana J; Aleskandarany, Mohammed; Rakha, Emad; Mohibi, Shakur; Band, Hamid; Band, Vimla

    2016-11-16

    We have established the critical role of ADA3 as a coactivator of estrogen receptor (ER), as well as its role in cell cycle progression. Furthermore, we showed that ADA3 is predominantly nuclear in mammary epithelium, and in ER+, but is cytoplasmic in ER- breast cancers, the latter correlating with poor survival. However, the role of nuclear ADA3 in human mammary epithelial cells (hMECs), and in ER+ breast cancer cells, as well as the importance of ADA3 expression in relation to patient prognosis and survival in ER+ breast cancer have remained uncharacterized. We overexpressed ADA3 in hMECs or in ER+ breast cancer cells and assessed the effect on cell proliferation. The expression of ADA3 was analyzed then correlated with the expression of various prognostic markers, as well as survival of breast cancer patients. Overexpression of ADA3 in ER- hMECs as well as in ER+ breast cancer cell lines enhanced cell proliferation. These cells showed increased cyclin B and c-MYC, decreased p27 and increased SKP2 levels. This was accompanied by increased mRNA levels of early response genes c-FOS, EGR1, and c-MYC. Analysis of breast cancer tissue specimens showed a significant correlation of ADA3 nuclear expression with c-MYC expression. Furthermore, nuclear ADA3 and c-MYC expression together showed significant correlation with tumor grade, mitosis, pleomorphism, NPI, ER/PR status, Ki67 and p27 expression. Importantly, within ER+ cases, expression of nuclear ADA3 and c-MYC also significantly correlated with Ki67 and p27 expression. Univariate Kaplan Meier analysis of four groups in the whole, as well as the ER+ patients showed that c-MYC and ADA3 combinatorial phenotypes showed significantly different breast cancer specific survival with c-MYC-high and ADA3-Low subgroup had the worst outcome. Using multivariate analyses within the whole cohort and the ER+ subgroups, the significant association of ADA3 and c-MYC expression with patients' outcome was independent of tumor grade

  1. DELTA: A Distal Enhancer Locating Tool Based on AdaBoost Algorithm and Shape Features of Chromatin Modifications.

    Directory of Open Access Journals (Sweden)

    Yiming Lu

    Full Text Available Accurate identification of DNA regulatory elements becomes an urgent need in the post-genomic era. Recent genome-wide chromatin states mapping efforts revealed that DNA elements are associated with characteristic chromatin modification signatures, based on which several approaches have been developed to predict transcriptional enhancers. However, their practical application is limited by incomplete extraction of chromatin features and model inconsistency for predicting enhancers across different cell types. To address these issues, we define a set of non-redundant shape features of histone modifications, which shows high consistency across cell types and can greatly reduce the dimensionality of feature vectors. Integrating shape features with a machine-learning algorithm AdaBoost, we developed an enhancer predicting method, DELTA (Distal Enhancer Locating Tool based on AdaBoost. We show that DELTA significantly outperforms current enhancer prediction methods in prediction accuracy on different datasets and can predict enhancers in one cell type using models trained in other cell types without loss of accuracy. Overall, our study presents a novel framework for accurately identifying enhancers from epigenetic data across multiple cell types.

  2. Genomic characterization of the Atlantic cod sex-locus.

    Science.gov (United States)

    Star, Bastiaan; Tørresen, Ole K; Nederbragt, Alexander J; Jakobsen, Kjetill S; Pampoulie, Christophe; Jentoft, Sissel

    2016-08-08

    A variety of sex determination mechanisms can be observed in evolutionary divergent teleosts. Sex determination is genetic in Atlantic cod (Gadus morhua), however the genomic location or size of its sex-locus is unknown. Here, we characterize the sex-locus of Atlantic cod using whole genome sequence (WGS) data of 227 wild-caught specimens. Analyzing more than 55 million polymorphic loci, we identify 166 loci that are associated with sex. These loci are located in six distinct regions on five different linkage groups (LG) in the genome. The largest of these regions, an approximately 55 Kb region on LG11, contains the majority of genotypes that segregate closely according to a XX-XY system. Genotypes in this region can be used genetically determine sex, whereas those in the other regions are inconsistently sex-linked. The identified region on LG11 and its surrounding genes have no clear sequence homology with genes or regulatory elements associated with sex-determination or differentiation in other species. The functionality of this sex-locus therefore remains unknown. The WGS strategy used here proved adequate for detecting the small regions associated with sex in this species. Our results highlight the evolutionary flexibility in genomic architecture underlying teleost sex-determination and allow practical applications to genetically sex Atlantic cod.

  3. Functional analysis of the TRIB1 associated locus linked to plasma triglycerides and coronary artery disease.

    Science.gov (United States)

    Douvris, Adrianna; Soubeyrand, Sébastien; Naing, Thet; Martinuk, Amy; Nikpay, Majid; Williams, Andrew; Buick, Julie; Yauk, Carole; McPherson, Ruth

    2014-06-03

    The TRIB1 locus has been linked to hepatic triglyceride metabolism in mice and to plasma triglycerides and coronary artery disease in humans. The lipid-associated single nucleotide polymorphisms (SNPs), identified by genome-wide association studies, are located ≈30 kb downstream from TRIB1, suggesting complex regulatory effects on genes or pathways relevant to hepatic triglyceride metabolism. The goal of this study was to investigate the functional relationship between common SNPs at the TRIB1 locus and plasma lipid traits. Characterization of the risk locus reveals that it encompasses a gene, TRIB1-associated locus (TRIBAL), composed of a well-conserved promoter region and an alternatively spliced transcript. Bioinformatic analysis and resequencing identified a single SNP, rs2001844, within the promoter region that associates with increased plasma triglycerides and reduced high-density lipoprotein cholesterol and coronary artery disease risk. Further, correction for triglycerides as a covariate indicated that the genome-wide association studies association is largely dependent on triglycerides. In addition, we show that rs2001844 is an expression trait locus (eQTL) for TRIB1 expression in blood and alters TRIBAL promoter activity in a reporter assay model. The TRIBAL transcript has features typical of long noncoding RNAs, including poor sequence conservation. Modulation of TRIBAL expression had limited impact on either TRIB1 or lipid regulatory genes mRNA levels in human hepatocyte models. In contrast, TRIB1 knockdown markedly increased TRIBAL expression in HepG2 cells and primary human hepatocytes. These studies demonstrate an interplay between a novel locus, TRIBAL, and TRIB1. TRIBAL is located in the genome-wide association studies identified risk locus, responds to altered expression of TRIB1, harbors a risk SNP that is an eQTL for TRIB1 expression, and associates with plasma triglyceride concentrations. © 2014 The Authors. Published on behalf of the

  4. Ada Compiler Validation Summary Report: Tartan Laboratories Incorporated, Tartan Ada ULTRIX. Version INT-3 VAX Station (Host & Target), 891207I1.10261

    Science.gov (United States)

    1989-12-07

    complete, or that the subject compiler has no nonconformities to the Ada Standard other than those presented. Copies of this report are available to...test for which the compiler generates a result that demonstrates nonconformity to the Ada Standard. Host The computer on which the compiler resides...A1408 and A1506 allow this behaviour . 1) Generic specifications and bodies can be compiled in separate compilations. (See tests CAl012A, CA2009C

  5. Ada Compiler Validation Summary Report. Certificate Number: 911003N1. 11222, International Computers Limited VME Ada Compiler VA3,00 ICL Series 39 Level 80

    Science.gov (United States)

    1991-01-01

    statements set forth in this report are accurate and complete, or that the subject implementation has no nonconformities to the Ada Standard other than those...Some of the class B tests contain legal Ada code which must not be flagged illegal by the compiler. This behaviour is also verified. Class L tests check...implementation’s behaviour should be graded as passed because the implementation passed the integer and fixed-point checks; the following REPORT.FAILED messages

  6. Characterization of a Multipeptide Lantibiotic Locus in Streptococcus pneumoniae

    Directory of Open Access Journals (Sweden)

    Natalie Maricic

    2016-01-01

    Full Text Available Bacterial communities are established through a combination of cooperative and antagonistic interactions between the inhabitants. Competitive interactions often involve the production of antimicrobial substances, including bacteriocins, which are small antimicrobial peptides that target other community members. Despite the nearly ubiquitous presence of bacteriocin-encoding loci, inhibitory activity has been attributed to only a small fraction of gene clusters. In this study, we characterized a novel locus (the pld locus in the pathogen Streptococcus pneumoniae that drives the production of a bacteriocin called pneumolancidin, which has broad antimicrobial activity. The locus encodes an unusual tandem array of four inhibitory peptides, three of which are absolutely required for antibacterial activity. The three peptide sequences are similar but appear to play distinct roles in regulation and inhibition. A modification enzyme typically found in loci encoding a class of highly modified bacteriocins called lantibiotics was required for inhibitory activity. The production of pneumolancidin is controlled by a two-component regulatory system that is activated by the accumulation of modified peptides. The locus is located on a mobile element that has been found in many pneumococcal lineages, although not all elements carry the pld genes. Intriguingly, a minimal region containing only the genes required for pneumolancidin immunity was found in several Streptococcus mitis strains. The pneumolancidin-producing strain can inhibit nearly all pneumococci tested to date and provided a competitive advantage in vivo. These peptides not only represent a unique strategy for bacterial competition but also are an important resource to guide the development of new antimicrobials.

  7. NRPA Law Review. Combat Karate Class Illustrates ADA "Direct Threat" Exception.

    Science.gov (United States)

    Kozlowski, James C.

    2000-01-01

    Describes the Americans with Disabilities Act (ADA), which prohibits discrimination against people with disabilities, highlighting a lawsuit involving a boy with AIDS who was barred from a traditional combat-oriented martial arts school. Courts ruled that his exclusion did not violate the ADA because he posed significant health and safety risks to…

  8. The G22A Polymorphism of the ADA Gene and Susceptibility to Autism Spectrum Disorders

    Science.gov (United States)

    Hettinger, Joe A.; Liu, Xudong; Holden, Jeanette Jeltje Anne

    2008-01-01

    Inborn errors of purine metabolism have been implicated as a cause for some cases of autism. This hypothesis is supported by the finding of decreased adenosine deaminase (ADA) activity in the sera of some children with autism and reports of an association of the A allele of the ADA G22A (Asp8Asn) polymorphism in individuals with autism of…

  9. Digital data sets that describe aquifer characteristics of the Vamoosa-Ada aquifer in east-central Oklahoma

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This data set consists of digitized water-level elevation contours for the Vamoosa-Ada aquifer in east-central Oklahoma. The Vamoosa-Ada aquifer is an important...

  10. Digital data sets that describe aquifer characteristics of the Vamoosa-Ada aquifer in east-central Oklahoma

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This data set consists of digitized polygons of constant hydraulic conductivity values for the Vamoosa-Ada aquifer in east-central Oklahoma. The Vamoosa-Ada aquifer...

  11. Digital data sets that describe aquifer characteristics of the Vamoosa-Ada aquifer in east-central Oklahoma

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This data set consists of digitized polygons of constant recharge values for the Vamoosa-Ada aquifer, in east-central Oklahoma. The Vamoosa-Ada aquifer is an...

  12. Digital data sets that describe aquifer characteristics of the Vamoosa-Ada aquifer in east-central Oklahoma

    Data.gov (United States)

    U.S. Geological Survey, Department of the Interior — This data set consists of digitized aquifer boundaries for the Vamoosa-Ada aquifer in east-central Oklahoma. The Vamoosa-Ada aquifer is an important source of water...

  13. Locus of Control and Religious Orientation.

    Science.gov (United States)

    Talbott, Anne Marie; Heritage, Jeannette

    Rotter's Internal-External Locus of Control Scale has been the focus of much research since its introduction in 1966. To further that research, the relationships among locus of control, level of religious belief, attitudes toward women, attitudes toward feminism, attitudes toward homosexuality, gender, and traditional versus nontraditional…

  14. Disability identity development model: Voices from the ADA-generation.

    Science.gov (United States)

    Forber-Pratt, Anjali J; Zape, Marianne P

    2017-04-01

    For persons with disabilities, 2015 was a historic year, marking the 25th anniversary of the Americans with Disability Act (ADA) and the 40th anniversary of the passing of the Individuals with Disabilities Education Act (IDEA). It is important to consider the effects of this fundamental shift towards equal opportunity and participation on persons with disabilities' identity development. In practice, however, there are few empirical studies that have looked at this phenomenon and even fewer models of disability identity development. We conducted a qualitative study to explore the disability identity development of college students with disabilities. At two research sites, we conducted individual interviews and observations with 17 college students with varying disabilities, and used in vivo and structural coding analysis to identify and develop themes. The results of this study led to establishing a model of psychosocial identity development for individuals with disabilities. The model highlights four developmental statuses: acceptance, relationship, adoption and engagement. Sharing voices from the participants themselves, we also provide commentary on the possible impacts of this work for healthcare professionals and areas for future research. Our findings suggest that this model of psychosocial disability identity development can help to provide an understanding of the psychological processes that individuals with disabilities go through. The model also has application as a framework for healthcare professionals and psychologists who are working with individuals with disabilities. Copyright © 2016 Elsevier Inc. All rights reserved.

  15. AdaBoost-based algorithm for network intrusion detection.

    Science.gov (United States)

    Hu, Weiming; Hu, Wei; Maybank, Steve

    2008-04-01

    Network intrusion detection aims at distinguishing the attacks on the Internet from normal use of the Internet. It is an indispensable part of the information security system. Due to the variety of network behaviors and the rapid development of attack fashions, it is necessary to develop fast machine-learning-based intrusion detection algorithms with high detection rates and low false-alarm rates. In this correspondence, we propose an intrusion detection algorithm based on the AdaBoost algorithm. In the algorithm, decision stumps are used as weak classifiers. The decision rules are provided for both categorical and continuous features. By combining the weak classifiers for continuous features and the weak classifiers for categorical features into a strong classifier, the relations between these two different types of features are handled naturally, without any forced conversions between continuous and categorical features. Adaptable initial weights and a simple strategy for avoiding overfitting are adopted to improve the performance of the algorithm. Experimental results show that our algorithm has low computational complexity and error rates, as compared with algorithms of higher computational complexity, as tested on the benchmark sample data.

  16. Ada (Trade Name) Compiler Validation Summary Report: Alsys Inc., AlsyCOMP 003, V3.1, HP Vectra.

    Science.gov (United States)

    1988-06-04

    constructs. The testing also identifies behaviour that is’ implementation dependent but permitted by the Ada Standard. Six classes of tests are used...poy.ted language constru’th ’~’,ired h 1-he Ada S*aindard. T: deteivmine that the implltinentati(,n-dependent behaviour is -i ’wed b, the Ada Standard...which the compiler generates a result that demonstrates nonconformity to the Ada Standard. 1-3 INTRODUCTION Host The computer on which the compiler

  17. Ada (Trade Name) Compiler Validation Summary Report: Alsys Inc., AlsyCOMP 003, V3.1, Intel 301

    Science.gov (United States)

    1988-06-04

    constructs. The testing also identifies behaviour that is implementation dependent but permitted by the Ada Standard. Six classes o, tests are used. These...1an’juage ’onsLructs required by the Ada Standard. To determine that the implementation-dependent behaviour is allowed by the Ada Standard , of this...demonstrates nonconformity to the Ada Standard. 1-3 1 INTRODUCTION Host The computer on which the compiler resides. Inapplicable A test that uses

  18. Regulatory Anatomy

    DEFF Research Database (Denmark)

    Hoeyer, Klaus

    2015-01-01

    This article proposes the term “safety logics” to understand attempts within the European Union (EU) to harmonize member state legislation to ensure a safe and stable supply of human biological material for transplants and transfusions. With safety logics, I refer to assemblages of discourses, le...... they arise. In short, I expose the regulatory anatomy of the policy landscape....

  19. The Semantics of Ada Access Types (Pointers) in the State Delta Verification System (SVDS).

    Science.gov (United States)

    1992-09-30

    AEROSPACE REPORT NO. ATR-92(2778)-5 The Semantics of Ada Access Types (Pointers) in the State Delta Verification System (SVDS) 30 September 1992 LgC...Engineering and Technology Group ". h: is. t ", -.- s -p I SOOPUBLIC RELEASE IS AUTHORIZED 19941214 006 Aerospace Report No. ATR-92(2778)-5 THE SEMANTICS OF ADA...NATIONAL SECURITY AGENCY Ft. George G. Meade, MD 20755-6000 PUBLIC RELEASE IS AUTHORIZED Report No. ATR-92(2778)-5 THE SEMANTICS OF ADA ACCESS TYPES

  20. CITY GROUND DESIGN AND THE IMAGE OF THE CITY: THE PORTUGUESE CALÇADA

    Directory of Open Access Journals (Sweden)

    Antoni Remesar

    2014-10-01

    The pavement-form - including the "calçada-form"-is at the root of some of the flagship operations creating the image of the city (Havana, 1928; Alicante, 1957; the Ramblas in Barcelona, 1969; reform of the Avenida Atlantica in Rio by Burle Marx, 1970. However, these same operations show that the "form-calçada" does not meet many of the requirements of economy, security or universal accessibility required by the contemporary city. In the paper was to analyze the causes and reasons that hover over the announced death of calçada á Portugueza.

  1. EL LOCUS DE DISTRIBUCION COMO COROLARIO DEL LOCUS DE CONTROL

    Directory of Open Access Journals (Sweden)

    Luisa Mayoral

    2009-01-01

    Full Text Available Este es un artículo científico acerca del Locus de Distribución, surgido de un estudio realizado con una población de docentes y alumnos universitarios. Respecto de los primeros, se ha indagado acerca de las atribuciones que se realizaban en torno a las recompensas y sanciones, que ellos distribuían a sus alumnos. Respecto de los segundos, se ha buscado determinar la valoración que estos realizaban de sus profesores, en términos de aquellas atribuciones. Para ello, se utilizaron dos paradigmas clásicamente empleados para verificar la existencia de una norma: el paradigma de la autopresentación (docentes, y el paradigma de los juicios (alumnos. La cuestión planteada fue determinar si en el caso de los comportamientos distributivos de refuerzos, las causas se atribuían a variables externas -en particular a los receptores de esos refuerzos- y si esas formas de atribución eran conocidas y valoradas o no, por los alumnos. De los resultados, surgió la confirmación de nuestra hipótesis de explicaciones externas en materia de comportamientos distributivos de sanciones en el ámbito de la docencia y la valoración positiva de estas atribuciones por los alumnos.

  2. Epigenetic features that regulate IgH locus recombination and expression.

    Science.gov (United States)

    Subrahmanyam, Ramesh; Sen, Ranjan

    2012-01-01

    Precisely regulated rearrangements that yield imprecise recombination junctions are hallmarks of antigen receptor gene assembly. At the immunoglobulin heavy chain (IgH) gene locus this is initiated by rearrangement of a D (H) gene segment to a J (H) gene segment to generate DJ(H) junctions, followed by rearrangement of a V (H) gene segment to the DJ(H) junction to generate fully recombined VDJ alleles. In this review we discuss the regulatory features of each step of IgH gene assembly and the role of epigenetic mechanisms in achieving regulatory precision.

  3. Translocations affecting human immunoglobulin heavy chain locus

    Directory of Open Access Journals (Sweden)

    Sklyar I. V.

    2014-03-01

    Full Text Available Translocations involving human immunoglobulin heavy chain (IGH locus are implicated in different leukaemias and lymphomas, including multiple myeloma, mantle cell lymphoma, Burkitt’s lymphoma and diffuse large B cell lymphoma. We have analysed published data and identified eleven breakpoint cluster regions (bcr related to these cancers within the IgH locus. These ~1 kbp bcrs are specific for one or several types of blood cancer. Our findings could help devise PCR-based assays to detect cancer-related translocations, to identify the mechanisms of translocations and to help in the research of potential translocation partners of the immunoglobulin locus at different stages of B-cell differentiation.

  4. Fusion of optimized indicators from Advanced Driver Assistance Systems (ADAS) for driver drowsiness detection

    National Research Council Canada - National Science Library

    Daza, Iván García; Bergasa, Luis Miguel; Bronte, Sebastián; Yebes, Jose Javier; Almazán, Javier; Arroyo, Roberto

    2014-01-01

    This paper presents a non-intrusive approach for monitoring driver drowsiness using the fusion of several optimized indicators based on driver physical and driving performance measures, obtained from ADAS...

  5. Fine-Tuning ADAS Algorithm Parameters for Optimizing Traffic Safety and Mobility in Connected Vehicle Environment

    Science.gov (United States)

    With the development of the Connected Vehicle technology that facilitates wirelessly communication among vehicles and road-side infrastructure, the Advanced Driver Assistance Systems (ADAS) can be adopted as an effective tool for accelerating traffic safety and mobility optimizat...

  6. A study of the portability of an Ada system in the software engineering laboratory (SEL)

    Science.gov (United States)

    Jun, Linda O.; Valett, Susan Ray

    1990-01-01

    A particular porting effort is discussed, and various statistics on analyzing the portability of Ada and the total staff months (overall and by phase) required to accomplish the rehost, are given. This effort is compared to past experiments on the rehosting of FORTRAN systems. The discussion includes an analysis of the types of errors encountered during the rehosting, the changes required to rehost the system, experiences with the Alsys IBM Ada compiler, the impediments encountered, and the lessons learned during this study.

  7. Vector-matrix-quaternion, array and arithmetic packages: All HAL/S functions implemented in Ada

    Science.gov (United States)

    Klumpp, Allan R.; Kwong, David D.

    1986-01-01

    The HAL/S avionics programmers have enjoyed a variety of tools built into a language tailored to their special requirements. Ada is designed for a broader group of applications. Rather than providing built-in tools, Ada provides the elements with which users can build their own. Standard avionic packages remain to be developed. These must enable programmers to code in Ada as they have coded in HAL/S. The packages under development at JPL will provide all of the vector-matrix, array, and arithmetic functions described in the HAL/S manuals. In addition, the linear algebra package will provide all of the quaternion functions used in Shuttle steering and Galileo attitude control. Furthermore, using Ada's extensibility, many quaternion functions are being implemented as infix operations; equivalent capabilities were never implemented in HAL/S because doing so would entail modifying the compiler and expanding the language. With these packages, many HAL/S expressions will compile and execute in Ada, unchanged. Others can be converted simply by replacing the implicit HAL/S multiply operator with the Ada *. Errors will be trapped and identified. Input/output will be convenient and readable.

  8. Locus of control and decision to abort.

    Science.gov (United States)

    Dixon, P N; Strano, D A; Willingham, W

    1984-04-01

    The relationship of locus of control to deciding on an abortion was investigated by administering Rotter's Locus of Control Scale to 118 women immediately prior to abortion and 2 weeks and 3 months following abortion. Subjects' scores were compared across the 3 time periods, and the abortion group's pretest scores were compared with those of a nonpregnant control, group. As hypothesized, the aborting group scored significantly more internal than the general population but no differences in locus of control were found across the 3 time period. The length of delay in deciding to abort an unwanted pregnancy following confirmation was also assessed. Women seeking 1st trimester abortions were divided into internal and external groups on the Rotter Scale and the lengths of delay were compared. The hypothesis that external scores would delay the decision longer than internal ones was confirmed. The results confirm characteristics of the locus of control construct and add information about personality characteristics of women undergoing abortion.

  9. A Revised Measure of Locus of Control

    Science.gov (United States)

    Clifford, Margaret M.

    1976-01-01

    A revised measure of locus of control for children and a summary of its descriptive statistics is presented. The nature of the instrument is discussed in light of Weiner's two-dimensional attribution table. (Author/MS)

  10. Maintaining (Locus of) Control? Assessing the Impact of Locus of Control on Education Decisions and Wages

    OpenAIRE

    Piatek, Rémi; Pinger, Pia

    2010-01-01

    This paper demonstrates that locus of control, i.e. whether individuals believe that reinforcement in life comes from their own actions instead of being determined by luck or destiny, is an important predictor of the decision to obtain higher education. Furthermore, the authors find that premarket locus of control, defined as locus of control measured at the time of schooling - before the individual enters the labor market - does not significantly affect later wages after controlling for educ...

  11. Culture, gender and locus of control

    DEFF Research Database (Denmark)

    Ottsen, Christina Lundsgaard; Johannessen, Kim Berg; Berntsen, Dorthe

    The current study is a cross-cultural comparison between the Middle East and Scandinavia. Two societies that offer a unique opportunity to examine gender differences in personal goals and how goals are affected by locus of control.......The current study is a cross-cultural comparison between the Middle East and Scandinavia. Two societies that offer a unique opportunity to examine gender differences in personal goals and how goals are affected by locus of control....

  12. Effect of locus of control on disordered eating in athletes: the mediational role of self-regulation of eating attitudes.

    Science.gov (United States)

    Scoffier, S; Paquet, Y; d'Arripe-Longueville, F

    2010-08-01

    This study examined the influence of locus of control on disordered eating as mediated by the self-regulation of eating attitudes. The assessment instruments were adapted for athletes as the entire sample of 179 volunteer University students (M(age)=21.12; SD=2.87) were all regularly involved in competition. The results showed that (a) an internal locus of control had a positive influence on the self-regulation of eating attitudes in social interaction contexts; (b) self-regulatory eating attitudes had a negative influence on disordered eating in contexts of negative affect, social interaction, and lack of anticipation of consequences on performance; and (c) an internal locus of control had an influence on disordered eating through the mediation of self-regulatory eating attitudes in social interaction contexts, and an external locus of control attributed to the coach and sports friends had an influence on disordered eating through the mediation of self-regulatory eating attitudes in contexts of negative affect, social interaction and lack of anticipation of consequences on performance. This study, combined with an earlier study from Scoffier, Maïano, and d'Arripe-Longueville (2009) on the antecedents of athletes' eating disorders, suggests the powerful impact of the social environment on the development of disordered eating in athletes. 2010 Elsevier Ltd. All rights reserved.

  13. Carrier frequency of a nonsense mutation in the adenosine deaminase (ADA) gene implies a high incidence of ADA-deficient severe combined immunodeficiency (SCID) in Somalia and a single, common haplotype indicates common ancestry

    DEFF Research Database (Denmark)

    Sanchez Sanchez, Juan Jose; Monaghan, Gemma; Børsting, Claus

    2007-01-01

    Inherited adenosine deaminase (ADA) deficiency is a rare metabolic disorder that causes immunodeficiency, varying from severe combined immunodeficiency (SCID) in the majority of cases to a less severe form in a small minority of patients. Five patients of Somali origin from four unrelated families......, with severe ADA-SCID, were registered in the Greater London area. Patients and their parents were investigated for the nonsense mutation Q3X (ADA c7C>T), two missense mutations K80R (ADA c239A>G) and R142Q (ADA c425G>A), and a TAAA repeat located at the 3' end of an Alu element (AluVpA) positioned 1.1 kb...... the frequency may be significantly higher. ADA-SCID may be a frequent immunodeficiency disorder in Somalia, but will be underdiagnosed due to the prevailing socioeconomic and nutritional deprivation....

  14. Regulatory Physiology

    Science.gov (United States)

    Lane, Helen W.; Whitson, Peggy A.; Putcha, Lakshmi; Baker, Ellen; Smith, Scott M.; Stewart, Karen; Gretebeck, Randall; Nimmagudda, R. R.; Schoeller, Dale A.; Davis-Street, Janis

    1999-01-01

    As noted elsewhere in this report, a central goal of the Extended Duration Orbiter Medical Project (EDOMP) was to ensure that cardiovascular and muscle function were adequate to perform an emergency egress after 16 days of spaceflight. The goals of the Regulatory Physiology component of the EDOMP were to identify and subsequently ameliorate those biochemical and nutritional factors that deplete physiological reserves or increase risk for disease, and to facilitate the development of effective muscle, exercise, and cardiovascular countermeasures. The component investigations designed to meet these goals focused on biochemical and physiological aspects of nutrition and metabolism, the risk of renal (kidney) stone formation, gastrointestinal function, and sleep in space. Investigations involved both ground-based protocols to validate proposed methods and flight studies to test those methods. Two hardware tests were also completed.

  15. Regulatory Benchmarking

    DEFF Research Database (Denmark)

    Agrell, Per J.; Bogetoft, Peter

    2017-01-01

    Benchmarking methods, and in particular Data Envelopment Analysis (DEA), have become well-established and informative tools for economic regulation. DEA is now routinely used by European regulators to set reasonable revenue caps for energy transmission and distribution system operators. The appli......Benchmarking methods, and in particular Data Envelopment Analysis (DEA), have become well-established and informative tools for economic regulation. DEA is now routinely used by European regulators to set reasonable revenue caps for energy transmission and distribution system operators....... The application of bench-marking in regulation, however, requires specific steps in terms of data validation, model specification and outlier detection that are not systematically documented in open publications, leading to discussions about regulatory stability and economic feasibility of these techniques...

  16. Regulatory Benchmarking

    DEFF Research Database (Denmark)

    Agrell, Per J.; Bogetoft, Peter

    2017-01-01

    Benchmarking methods, and in particular Data Envelopment Analysis (DEA), have become well-established and informative tools for economic regulation. DEA is now routinely used by European regulators to set reasonable revenue caps for energy transmission and distribution system operators. The appli......Benchmarking methods, and in particular Data Envelopment Analysis (DEA), have become well-established and informative tools for economic regulation. DEA is now routinely used by European regulators to set reasonable revenue caps for energy transmission and distribution system operators....... The application of benchmarking in regulation, however, requires specific steps in terms of data validation, model specification and outlier detection that are not systematically documented in open publications, leading to discussions about regulatory stability and economic feasibility of these techniques...

  17. Major histocompatibility complex class II DOA sequences from three Antarctic seal species verify stabilizing selection on the DO locus.

    Science.gov (United States)

    Decker, D J; Stewart, B S; Lehman, N

    2002-12-01

    To provide additional support for the sequence conservation and hence the regulatory role of the MHC class II DOA locus, we obtained the nucleotide sequences of exon 2 and exon 3, along with the intervening intron, of the Ross seal, and sequences from the exon 2 region from the Weddell and leopard seals. These are the first reports of the sequences of this locus from a carnivore species. The results demonstrate strong conservation among mammals for the exon sequence and produce a gene genealogy that is consistent in topology with a species tree.

  18. Targeted transposition at the vestigial locus of Drosophila melanogaster.

    Science.gov (United States)

    Heslip, T R; Hodgetts, R B

    1994-12-01

    Targeted transposition is the replacement of one P element with another. We are exploiting this unique property of P elements to study the complex regulatory domain of the Dopa decarboxylase (Ddc) gene in Drosophila melanogaster. P element constructs targeted to the same site in the genome will be subjected to the same position effect. This allows the subtle effects typical of most mutations in the Ddc regulatory region to be measured in the absence of the variable influences of position effects which are associated with the current method of germline transformation. We have investigated some of the parameters affecting targeted transposition of a Ddc transposon, P[Ddc], into a P element allele at the vestigial locus. These events were detected by an increased mutant vg phenotype. The location of the donor transposon in cis or in trans to the target had little effect on the frequency of targeting. Likewise, the mobility of different donor elements, as measured by their rate of transposition to a different chromosome, varied nearly 20-fold, while the rate of targeted transposition was very similar between them. All targeted alleles were precise replacements of the target P element by P[Ddc], but in several cases the donor was inserted in the opposite orientation. The targeted alleles could be described as the result of a replicative, conversion-like event.

  19. The inclusion of ADA-SCID in expanded newborn screening by tandem mass spectrometry.

    Science.gov (United States)

    la Marca, Giancarlo; Giocaliere, Elisa; Malvagia, Sabrina; Funghini, Silvia; Ombrone, Daniela; Della Bona, Maria Luisa; Canessa, Clementina; Lippi, Francesca; Romano, Francesca; Guerrini, Renzo; Resti, Massimo; Azzari, Chiara

    2014-01-01

    Severe combined immunodeficiency due to adenosine-deaminase defect (ADA-SCID) is usually deadly in childhood because of severe recurrent infections. When clinical diagnosis is done, permanent damages due to infections or metabolite accumulation are often present. Gene therapy, bone marrow transplantation or enzyme replacement therapy may be effective if started early. The aim of this study was to set-up a robust method suitable for screening with a minimized preparation process and with inexpensive running costs, for diagnosing ADA-SCID by tandem mass spectrometry. ADA-SCID satisfies all the criteria for inclusion in a newborn screening program. We describe a protocol revised to incorporate adenosine and 2-deoxyadenosine testing into an expanded newborn screening program. We assessed the effectiveness of this approach testing dried blood spots from 4 genetically confirmed early-onset and 5 delayed-onset ADA-SCID patients. Reference values were established on 50,000 healthy newborns (deoxyadenosine <0.09μmol/L, adenosine <1.61μmol/L). We also developed a second tier test to distinguish true positives from false positives and improve the positive predictive value of an initial abnormal result. In the first 18 months, the pilot project has identified a newborn with a genetically confirmed defect in adenosine deaminase (ADA) gene. The results show that the method having great simplicity, low cost and low process preparations can be fully applicable to a mass screening program. Copyright © 2013 Elsevier B.V. All rights reserved.

  20. The murine Th2 locus undergoes epigenetic modification in the thymus during fetal and postnatal ontogeny.

    Directory of Open Access Journals (Sweden)

    Momoko Yoshimoto

    Full Text Available Epigenetic modifications play a central role in the differentiation and function of immune cells in adult animals. Developmentally regulated epigenetic patterns also appear to contribute to the ontogeny of the immune system. We show here that the epigenetic profile of the T-helper (Th 2 locus undergoes changes in T lineage cells beginning in mid-gestation and extending throughout the first week of life. In particular, regulatory regions of the Th2 locus are largely methylated at CpG residues among fetal liver common lymphoid progenitor cells. The locus subsequently becomes highly hypomethylated among the downstream progeny of these cells within the fetal thymus. This hypomethylated state is preserved until birth when the locus becomes rapidly re-methylated, achieving adult-like status by 3-6 days post birth. Notably, the capacity for rapid, high level Th2 cytokine production is lost in parallel with this re-methylation. In vitro organ culture and in vivo transplantation experiments indicate that signals from the adult environment are required to achieve the postnatal methylated state. Together, these findings indicate that the Th2 bias of neonates may be conferred, in part, by an epigenetic profile inherited from fetal life. However, the fetal program is rapidly terminated post birth by the development of signals leading to the acquisition of adult-like epigenetic patterns.

  1. Pegademase bovine (PEG-ADA for the treatment of infants and children with severe combined immunodeficiency (SCID

    Directory of Open Access Journals (Sweden)

    Claire Booth

    2009-06-01

    Full Text Available Claire Booth1,2, H Bobby Gaspar1,21Centre for Immunodeficiency, Molecular Immunology Unit, UCL Institute of Child Health, London, UK; 2Dept of Clinical Immunology, Great Ormond Street Hospital NHS Trust, London, UKAbstract: Adenosine deaminase deficiency (ADA is a rare, inherited disorder of purine metabolism characterized by immunodeficiency, failure to thrive and metabolic abnormalities. A lack of the enzyme ADA allows accumulation of toxic metabolites causing defects of both cell mediated and humoral immunity leading to ADA severe combined immune deficiency (SCID, a condition that can be fatal in early infancy if left untreated. Hematopoietic stem cell transplant is curative but is dependent on a good donor match. Other therapeutic options include enzyme replacement therapy (ERT with pegademase bovine (PEG-ADA and more recently gene therapy. PEG-ADA has been used in over 150 patients worldwide and has allowed stabilization of patients awaiting more definitive treatment with hematopoietic stem cell transplant. It affords both metabolic detoxification and protective immune function with patients remaining clinically well, but immune reconstitution is often suboptimal and may not be long lived. We discuss the pharmacokinetics, immune reconstitution, effects on systemic disease and side effects of treatment with PEG-ADA. We also review the long-term outcome of patients receiving ERT and discuss the role of PEG-ADA in the management of infants and children with ADA-SCID, alongside other therapeutic options.Keywords: adenosine deaminase deficiency, PEG-ADA, enzyme replacement therapy, severe combined immune deficiency (SCID

  2. Ada (Tradename) Compiler Validation Summary Report. Tolerant Systems Tolerant Ada Development System (TX (Trademark)/VADS (Tradename), Part Number S-240, Version 1.0. Tolerant Eternity (Trademark).

    Science.gov (United States)

    1986-05-11

    behavior that is implementation dependent but permitted by ANSI/HIL-STD-1815A. Six classes of tests are used. These tests are designed to perform checks at...be reset. I llegal file names can exist. ACVC VTetion 17 was taken on-site via magnetic Vape tofan Jose, CA. ., All tests, except the withdrawn tests...identify any unsupported language constructs required by the Ada Standard " To determine that the implementation-dependent behavior is allowed by the

  3. Kartenorientierte Isolierung des Rar1 Locus

    OpenAIRE

    Lahaye, Thomas

    1999-01-01

    The Mla12 allele of the barley-Mla locus confers resistance to powdery mildew isolates expressing the matching avirulence gene avrMla12. The Rar1 (Required for Mla12-specified resistance) locus has been found to be part of the Mla12-governed signal transduction pathway. Previous analysis has demonstrated that rar1-mutant alleles abolish not only Mla12 but also other R gene specificities. To elucidate the molecular mechanisms of R-gene mediated plant defence Rar1 was isolated by map-based clon...

  4. Locus of control in relation to flow

    Directory of Open Access Journals (Sweden)

    Celeste M Taylor

    2006-03-01

    Full Text Available The principal objective of the study was to examine the relationship between locus of control and optimal experience (flow in carrying out work and/or study activities. Two questionnaires measuring the aforementioned constructs were administered to a group of first and second-year Human Resource Management students (n=168 between the ages of 16 and 30. The results suggest that more frequent experience of flow is positively correlated with Autonomy and Internal Locus of Control. Limitations, lines of future research, implications and further contributions are discussed.

  5. Locus of control in children of divorce.

    Science.gov (United States)

    Kalter, N; Alpern, D; Spence, R; Plunkett, J W

    1984-08-01

    Scores on the Nowicki-Strickland Locus of Control Scale for Children (N-SLOCSC) were compared for third and fifth grade boys and girls from intact versus maritally disrupted family backgrounds. Significant main effects for each independent variable revealed that fifth graders more than third, boys more than girls, and the marital disruption more than the intact group, exhibited higher internality in their locus of control scores. These findings strongly suggest that experiencing a parental divorce in childhood has a significant influence on generalized perceptions of personal control and effectance, perceptions which may ultimately mediate both short- and long-term outcomes in children's post-divorce adjustment.

  6. The Spectrum Sensing Algorithm Based AdaBoost in Cognitive Radio

    Science.gov (United States)

    Tian, Deyong; Wang, Xin

    To solve the low detection rate of the primary user in the cognitive radio environment, we propose a spectrum sensing method based on AdaBoost in the case of low SNR. In this paper, a set of received signal spectrum features are first calculated and extracted the discriminant feature vector as training samples and testing samples for classification. Finally, we utilize the trained AdaBoost to detect the primary user. Test result shows that the proposed algorithm is not affected by uncertainty factors of noise and has high performance to classification detection compared with ANN, SVM and maximum-minimum eigenvalue (MME).

  7. Phylogenetic Analysis of the SNORD116 Locus

    Directory of Open Access Journals (Sweden)

    Matthew A. Kocher

    2017-11-01

    Full Text Available The SNORD116 small nucleolar RNA locus (SNORD116@ is contained within the long noncoding RNA host gene SNHG14 on human chromosome 15q11-q13. The SNORD116 locus is a cluster of 28 or more small nucleolar (sno RNAs; C/D box (SNORDs. Individual RNAs within the cluster are tandem, highly similar sequences, referred to as SNORD116-1, SNORD116-2, etc., with the entire set referred to as SNORD116@. There are also related SNORD116 loci on other chromosomes, and these additional loci are conserved among primates. Inherited chromosomal 15q11-q13 deletions, encompassing the SNORD116@ locus, are causative for the paternally-inherited/maternally-imprinted genetic condition, Prader–Willi syndrome (PWS. Using in silico tools, along with molecular-based and sequenced-based confirmation, phylogenetic analysis of the SNORD116@ locus was performed. The consensus sequence for the SNORD116@ snoRNAs from various species was determined both for all the SNORD116 snoRNAs, as well as those grouped using sequence and location according to a human grouping convention. The implications of these findings are put in perspective for studying SNORD116 in patients with inherited Prader–Willi syndrome, as well as model organisms.

  8. Aspirations, Attributions, and Locus of Control.

    Science.gov (United States)

    Samuel, William; McNall, Sidne J.

    Self-evaluation is thought to play a major role in personality and motivation. Preliminary experience with success or failure, levels of aspiration, attributions for performance, and locus of control may all be interrelated factors in human motivation. After receiving success, failure, or no feedback on a concept formation task, subjects (N=90)…

  9. Locus of Equity and Brand Extension

    NARCIS (Netherlands)

    S.M.J. van Osselaer (Stijn); J.W. Alba (Joseph)

    2003-01-01

    textabstractPrevailing wisdom assumes that brand equity increases when a brand touts its desirable attributes. We report conditions under which the use of attribute information to promote a product can shift the locus of equity from brand to attribute, thereby reducing the attractiveness of

  10. Lessons learned: Managing the development of a corporate Ada training project

    Science.gov (United States)

    Blackmon, Linda F.

    1986-01-01

    The management lessons learned during the implementation of a corporate mandate to develop and deliver an effective Ada training program to all divisions are discussed. The management process involved in obtaining cooperation from all levels in the development of a corporate-wide project is described. The problem areas are identified along with some possible solutions.

  11. Anemia nos pacientes com insuficiência cardíaca avançada

    Directory of Open Access Journals (Sweden)

    Juliano Cardoso

    2010-10-01

    Full Text Available FUNDAMENTO: Anemia está associada à pior evolução nos pacientes com insuficiência cardíaca (IC. Entretanto, há poucos estudos sobre a anemia nos pacientes com IC avançada. OBJETIVO: Avaliar as características da anemia na IC em fase avançada. MÉTODOS: Foram incluídos 99 pacientes hospitalizados para compensação de IC (CF IV/NYHA, com idade > 18 anos e FEVE 12 g/dl. A anemia foi marcador independente de mau prognóstico na análise multivariada (mortalidade 47% vs 24,6%, p = 0,016, risco relativo 2,54. CONCLUSÃO: Anemia acomete, aproximadamente, 1/3 dos pacientes com IC avançada, e a deficiência de ferro é uma importante etiologia. Pacientes anêmicos são mais idosos e apresentaram função renal mais deteriorada. A melhora da congestão não foi suficiente para melhorar a anemia na maioria dos casos. Nos pacientes com IC avançada, a anemia é marcador independente de mau prognóstico.

  12. Revising the ADAS-cog for a more accurate assessment of cognitive impairment

    NARCIS (Netherlands)

    Wouters, Hans; van Gool, Willem A; Schmand, Ben; Lindeboom, Robert

    2008-01-01

    BACKGROUND: To examine whether it is appropriate to sum the cognitive part of the Alzheimer Disease Assessment Scale (ADAS-cog) items to assess cognitive impairment. This assumes items to have (1) equal measurement precision and (2) hierarchically ordered categories. METHODS: Rasch analysis on the

  13. Revising the ADAS-cog for a more accurate assessment of cognitive impairment

    NARCIS (Netherlands)

    Wouters, H.; van Gool, W.A.; Schmand, B.; Lindeboom, R.

    2008-01-01

    Background: To examine whether it is appropriate to sum the cognitive part of the Alzheimer Disease Assessment Scale (ADAS-cog) items to assess cognitive impairment. This assumes items to have (1) equal measurement precision and (2) hierarchically ordered categories. Methods: Rasch analysis on the

  14. Towards a new form of African novel:Ada Ugah's Theory of the novel ...

    African Journals Online (AJOL)

    This paper analyses the balladic novel as initiated by Ada Ugah and highlights its advantages over the traditional novelistic format greatly influenced by the European romance tradition. Texts that provide material for the analysis include Ugah's first two trail-blazers: Ballads of the unknown soldier (a novel in ballads) and ...

  15. Automatic Player Detection and Recognition in Images Using AdaBoost

    NARCIS (Netherlands)

    Mahmood, Zahid; Ali, Tauseef; Khattak, Shadid

    2012-01-01

    In this work we developed an augmented reality sports broadcasting application for enhanced end-user experience. The proposed system consists of three major steps. In the first step each player is detected using AdaBoost Algorithm. In second step, same algorithm is used to detect face in each player

  16. 75 FR 43747 - Americans With Disabilities Act (ADA) Accessibility Guidelines for Transportation Vehicles

    Science.gov (United States)

    2010-07-26

    ... Transportation Barriers Compliance Board 36 CFR Parts 1192 Americans With Disabilities Act (ADA) Accessibility... Act requires barriers in existing transportation vehicles used by public accommodations for transporting individuals and by private entities to provide specified public transportation to be removed where...

  17. 75 FR 18781 - Americans With Disabilities Act (ADA) Accessibility Guidelines for Buildings and Facilities...

    Science.gov (United States)

    2010-04-13

    ... and Transportation Barriers Compliance Board (Access Board) will hold a public hearing on its refresh... TRANSPORTATION BARRIERS COMPLIANCE BOARD 36 CFR Parts 1191, 1193, and 1194 RIN 3014-AA37 Americans With Disabilities Act (ADA) Accessibility Guidelines for Buildings and Facilities; Telecommunications Act...

  18. Getting ADAS on the Road : Actors' Interactions in Advanced Driver Assistance Systems Deployment

    NARCIS (Netherlands)

    Walta, L.

    2011-01-01

    Currently, many car drivers spend many hours in congested traffic. If their cars would have been equipped with an electronic system that automatically follows the car in front of them, congestion might have been prevented. Such a system is an example of Advanced Driver Assistance Systems (ADAS).

  19. Association between the Igk and Igh loci mediated by the 3’ Igk enhancer induces decontraction of the Igh locus in pre-B cells

    Science.gov (United States)

    Hewitt, Susannah L; Farmer, Deborah; Marszalek, Katarzyna; Cadera, Emily; Liang, Hong-Erh; Xu, Yang; Schlissel, Mark S; Skok, Jane A

    2008-01-01

    V(D)J recombination at Igh and Igk loci takes place sequentially during successive stages in B cell development. Using 3-dimensional DNA fluorescence in situ hybridization (FISH), we identified a lineage- and stage-specific interchromosomal association between these two loci which marks the transition between Igh and Igk recombination. Co-localization occured between pericentromerically located alleles in pre-B cells, and was mediated by the 3’ Igk enhancer. Deletion of this regulatory element prevented association of the Igh and Igk loci, inhibited pericentromeric recruitment and locus decontraction of an Igh allele, and resulted in increased distal VH gene rearrangement. Our data indicate a role for the Igk locus and its 3’ enhancer in directing the Igh locus to a repressive nuclear subcompartment, and in rendering the Igh locus unable to contract. PMID:18297074

  20. Association between the Igk and Igh immunoglobulin loci mediated by the 3' Igk enhancer induces 'decontraction' of the Igh locus in pre-B cells.

    Science.gov (United States)

    Hewitt, Susannah L; Farmer, Deborah; Marszalek, Katarzyna; Cadera, Emily; Liang, Hong-Erh; Xu, Yang; Schlissel, Mark S; Skok, Jane A

    2008-04-01

    Variable-(diversity)-joining (V(D)J) recombination at loci encoding the immunoglobulin heavy chain (Igh) and immunoglobulin light chain (Igk) takes place sequentially during successive stages in B cell development. Using three-dimensional DNA fluorescence in situ hybridization, here we identify a lineage-specific and stage-specific interchromosomal association between these two loci that marks the transition between Igh and Igk recombination. Colocalization occurred between pericentromerically located alleles in pre-B cells and was mediated by the 3' Igk enhancer. Deletion of this regulatory element prevented association of the Igh and Igk loci, inhibited pericentromeric recruitment and locus 'decontraction' of an Igh allele, and resulted in greater distal rearrangement of the gene encoding the variable heavy-chain region. Our data indicate involvement of the Igk locus and its 3' enhancer in directing the Igh locus to a repressive nuclear subcompartment and inducing the Igh locus to decontract.

  1. Alterations in the brain adenosine metabolism cause behavioral and neurological impairment in ADA-deficient mice and patients

    Science.gov (United States)

    Sauer, Aisha V.; Hernandez, Raisa Jofra; Fumagalli, Francesca; Bianchi, Veronica; Poliani, Pietro L.; Dallatomasina, Chiara; Riboni, Elisa; Politi, Letterio S.; Tabucchi, Antonella; Carlucci, Filippo; Casiraghi, Miriam; Carriglio, Nicola; Cominelli, Manuela; Forcellini, Carlo Alberto; Barzaghi, Federica; Ferrua, Francesca; Minicucci, Fabio; Medaglini, Stefania; Leocani, Letizia; la Marca, Giancarlo; Notarangelo, Lucia D.; Azzari, Chiara; Comi, Giancarlo; Baldoli, Cristina; Canale, Sabrina; Sessa, Maria; D’Adamo, Patrizia; Aiuti, Alessandro

    2017-01-01

    Adenosine Deaminase (ADA) deficiency is an autosomal recessive variant of severe combined immunodeficiency (SCID) caused by systemic accumulation of ADA substrates. Neurological and behavioral abnormalities observed in ADA-SCID patients surviving after stem cell transplantation or gene therapy represent an unresolved enigma in the field. We found significant neurological and cognitive alterations in untreated ADA-SCID patients as well as in two groups of patients after short- and long-term enzyme replacement therapy with PEG-ADA. These included motor dysfunction, EEG alterations, sensorineural hypoacusia, white matter and ventricular alterations in MRI as well as a low mental development index or IQ. Ada-deficient mice were significantly less active and showed anxiety-like behavior. Molecular and metabolic analyses showed that this phenotype coincides with metabolic alterations and aberrant adenosine receptor signaling. PEG-ADA treatment corrected metabolic adenosine-based alterations, but not cellular and signaling defects, indicating an intrinsic nature of the neurological and behavioral phenotype in ADA deficiency. PMID:28074903

  2. The Impact of Locus of Control on Language Achievement

    Science.gov (United States)

    Nodoushan, Mohammad Ali Salmani

    2012-01-01

    This study hypothesized that students' loci of control affected their language achievement. 198 (N = 198) EFL students took the Rotter's (1966) locus of control test and were classified as locus-internal (ni = 78), and locus-external (ne = 120). They then took their ordinary courses and at the end of the semester, they were given their exams.…

  3. Study on the Method of Face Detection Based on Chaos Genetic Algorithm Optimization AdaBoost Algorithm

    Directory of Open Access Journals (Sweden)

    Chai Yu

    2017-01-01

    Full Text Available Aiming at the problems that the traditional AdaBoost algorithm has complex feature computation, long training time and low detection rate, a method of face detection based on chaos genetic algorithm optimization adaBoost algorithm was proposed. Firstly, this algorithm uses the image color segmentation for coarse screening on the face image, in order to determine the human skin area. Secondly, the adaptive median filtering is applied to denoise the face image to improve the quality of the face image. Finally, the chaotic genetic algorithm is used to optimize the AdaBoost algorithm to achieve higher detection rate and detection speed. Compared with the traditional AdaBoost algorithm, the experimental results showed that the face detection method based on chaos genetic algorithm optimization AdaBoost algorithm proposed in this paper has a significant improvement in detection rate and detection speed.

  4. Polycomb mediated epigenetic silencing and replication timing at the INK4a/ARF locus during senescence.

    Directory of Open Access Journals (Sweden)

    Hanane Agherbi

    Full Text Available BACKGROUND: The INK4/ARF locus encodes three tumor suppressor genes (p15(Ink4b, Arf and p16(Ink4a and is frequently inactivated in a large number of human cancers. Mechanisms regulating INK4/ARF expression are not fully characterized. PRINCIPAL FINDINGS: Here we show that in young proliferating embryonic fibroblasts (MEFs the Polycomb Repressive Complex 2 (PRC2 member EZH2 together with PRC1 members BMI1 and M33 are strongly expressed and localized at the INK4/ARF regulatory domain (RD identified as a DNA replication origin. When cells enter senescence the binding to RD of both PRC1 and PRC2 complexes is lost leading to a decreased level of histone H3K27 trimethylation (H3K27me3. This loss is accompanied with an increased expression of the histone demethylase Jmjd3 and with the recruitment of the MLL1 protein, and correlates with the expression of the Ink4a/Arf genes. Moreover, we show that the Polycomb protein BMI1 interacts with CDC6, an essential regulator of DNA replication in eukaryotic cells. Finally, we demonstrate that Polycomb proteins and associated epigenetic marks are crucial for the control of the replication timing of the INK4a/ARF locus during senescence. CONCLUSIONS: We identified the replication licencing factor CDC6 as a new partner of the Polycomb group member BMI1. Our results suggest that in young cells Polycomb proteins are recruited to the INK4/ARF locus through CDC6 and the resulting silent locus is replicated during late S-phase. Upon senescence, Jmjd3 is overexpressed and the MLL1 protein is recruited to the locus provoking the dissociation of Polycomb from the INK4/ARF locus, its transcriptional activation and its replication during early S-phase. Together, these results provide a unified model that integrates replication, transcription and epigenetics at the INK4/ARF locus.

  5. Participatory workplace wellness programs: reward, penalty, and regulatory conflict.

    Science.gov (United States)

    Pomeranz, Jennifer L

    2015-06-01

    POLICY POINTS: Workplace wellness programs that provide incentives for completing a health risk assessment are a form of participatory programs. There are legal and ethical concerns when employers assess penalties for not completing a health risk assessment, raising questions about the voluntariness of such a program. The Departments of Treasury, Labor, and Health and Human Services' 2013 regulations for participatory programs and employers' current practices conflict with the Equal Employment Opportunity Commission's prevailing interpretation of the Americans with Disabilities Act of 1990. In keeping with the Patient Protection and Affordable Care Act, Congress revised the law related to workplace wellness programs. In June 2013, the Departments of Treasury, Labor, and Health and Human Services passed the final regulations, updating their 2006 regulatory framework. Participatory programs that reward the completion of a health risk assessment are now the most common type of wellness program in the United States. However, legal and ethical concerns emerge when employers utilize incentives that raise questions about the voluntariness of such programs. At issue is that under the Americans with Disabilities Act (ADA) of 1990, employers cannot require health-related inquiries and exams. To analyze the current interpretation of the ADA, I conducted research on both LexisNexis and federal agency websites. The resulting article evaluates the differences in the language of Congress's enabling legislation and the federal departments' regulations and how they may conflict with the ADA. It also reviews the federal government's authority to address both the legal conflict and ethical concerns related to nonvoluntary participatory programs. Employers' practices and the federal departments' regulations conflict with the current interpretation of the ADA by permitting employers to penalize employees who do not complete a health risk assessment. The departments' regulations may be

  6. Ada Compiler Validation Summary Report. Certificate Number: 891126I1. 10217, TeleSoft TeleGen2 Ada Development System for Hewlett-Packard 9000/370. Completion of On-Site Testing: 26 November 1989

    Science.gov (United States)

    1989-11-26

    ond dentf) by block number) TeleSoft, TeleGen2 Ada Development System, Version 1.4, Ottobrunn West Germany, Hewlett - Parkard 9000/370 under HP/UX 6.5...Report:TeleSoft, 26 Nov. 1989 to 26 Nov. 1990 TeleGen2 Ada Development Systems for Hewlett -Packard 9000’ 7 PLRFORMING’DRG. REPORT NUMBER /370 (Host...TeleSoft TeleGen2 Ada Develonpt- System for Hewlett -Packard 90no/70 Completion of On-Site Testing: 26 November 1989 Prepared y: ZABG nbH, A-bt. SZT

  7. Induced and natural variation of promoter length modulates the photoperiodic response of FLOWERING LOCUS T.

    Science.gov (United States)

    Liu, Liangyu; Adrian, Jessika; Pankin, Artem; Hu, Jinyong; Dong, Xue; von Korff, Maria; Turck, Franziska

    2014-08-04

    FLOWERING LOCUS T (FT) regulates the floral transition in many plant species by integrating environmental seasonal signals and internal cues. Here we show that two interdependent regulatory regions are necessary and sufficient to convey photoperiod responsiveness to FT. While a minimal distance between the regulatory regions is required to fully suppress FT expression under short days, increased distance reduces promoter response to long days. Natural variation at FT creating promoter length differences is widespread, correlates with longitudinal and latitudinal clines and affects a promoter region physically interacting with both photoperiod control regions. Three major FT promoter variants correlate with differences in FT allele usage in F1 hybrids. We propose that FT variation in cis could be adaptive by conferring differences in FT transcriptional control ultimately translating to increased fitness.

  8. The handedness-associated PCSK6 locus spans an intronic promoter regulating novel transcripts.

    Science.gov (United States)

    Shore, Robert; Covill, Laura; Pettigrew, Kerry A; Brandler, William M; Diaz, Rebeca; Xu, Yiwang; Tello, Javier A; Talcott, Joel B; Newbury, Dianne F; Stein, John; Monaco, Anthony P; Paracchini, Silvia

    2016-05-01

    We recently reported the association of the PCSK6 gene with handedness through a quantitative genome-wide association study (GWAS; P left-right body axis determination. Therefore, the GWAS data suggest that the biology underlying the patterning of structural asymmetries may also contribute to behavioural laterality, e.g. handedness. The association is further supported by an independent study reporting a variable number tandem repeat (VNTR) within the same PCSK6 locus to be associated with degree of handedness in a general population cohort. Here, we have conducted a functional analysis of the PCSK6 locus combining further genetic analysis, in silico predictions and molecular assays. We have shown that the previous GWAS signal was not tagging a VNTR effect, suggesting that the two markers have independent effects. We demonstrated experimentally that one of the top GWAS-associated markers, rs11855145, directly alters the binding site for a nuclear factor. Furthermore, we have shown that the predicted regulatory region adjacent to rs11855415 acts as a bidirectional promoter controlling the expression of novel RNA transcripts. These include both an antisense long non-coding RNA (lncRNA) and a short PCSK6 isoform predicted to be coding. This is the first molecular characterization of a handedness-associated locus that supports the role of common variants in non-coding sequences in influencing complex phenotypes through gene expression regulation. © The Author 2016. Published by Oxford University Press.

  9. Locus-Specific DNA Methylation Reprogramming During Early Porcine Embryogenesis1

    Science.gov (United States)

    Zhao, Ming-Tao; Rivera, Rocio M.; Prather, Randall S.

    2013-01-01

    ABSTRACT During early mammalian embryogenesis, there is a wave of DNA demethylation postfertilization and de novo methylation around implantation. The paternal genome undergoes active DNA demethylation, whereas the maternal genome is passively demethylated after fertilization in most mammals except for sheep and rabbits. However, the emerging genome-wide DNA methylation landscape has revealed a regulatory and locus-specific DNA methylation reprogramming pattern in mammalian preimplantation embryos. Here we optimized a bisulfite sequencing protocol to draw base-resolution DNA methylation profiles of several selected genes in gametes, early embryos, and somatic tissue. We observed locus-specific DNA methylation reprogramming in early porcine embryos. First, some pluripotency genes (POU5F1 and NANOG) followed a typical wave of DNA demethylation and remethylation, whereas CpG-rich regions of SOX2 and CDX2 loci were hypomethylated throughout development. Second, a differentially methylated region of an imprint control region in the IGF2/H19 locus exhibited differential DNA methylation which was maintained in porcine early embryos. Third, a centromeric repeat element retained a moderate DNA methylation level in gametes, early embryos, and somatic tissue. The diverse DNA methylation reprogramming during early embryogenesis is thought to be possibly associated with the multiple functions of DNA methylation in transcriptional regulation, genome stability and genomic imprinting. The latest technology such as oxidative bisulfite sequencing to identify 5-hydroxymethylcytosine will further clarify the DNA methylation reprogramming during porcine embryonic development. PMID:23303676

  10. Requirement for enhancer specificity in immunoglobulin heavy chain locus regulation1

    Science.gov (United States)

    Kuzin, Igor I.; Bagaeva, Ludmila; Young, Faith M.; Bottaro, Andrea

    2008-01-01

    The intronic Eμ enhancer has been implicated in immunoglobulin heavy chain (IgH) locus transcription, VDJ recombination, class switch recombination (CSR)2 and somatic hypermutation (SHM). How Eμ controls these diverse mechanisms is still largely unclear, but transcriptional enhancer activity is thought to play a central role. Here we compare the phenotype of mice lacking the Eμ element (ΔEμ) with that of mice in which Eμ was replaced with the ubiquitous SV40 transcriptional enhancer (SV40eR mutation), and show that SV40e cannot functionally complement Eμ loss in pro-B cells. Surprisingly, in fact, the SV40eR mutation yields a more profound defect than ΔEμ, with an almost complete block in μ0 germline transcription in pro-B cells. This active transcriptional suppression caused by enhancer replacement appears to be specific to the early stages of B cell development, as mature SV40eR B cells express μ0 transcripts at higher levels than ΔEμ mice, and undergo complete DNA demethylation at the IgH locus. These results indicate an unexpectedly stringent, developmentally-restricted requirement for enhancer specificity in regulating IgH function during the early phases of B cell differentiation, consistent with the view that coordination of multiple independent regulatory mechanisms and elements is essential for locus activation and VDJ recombination. PMID:18490744

  11. Rapid license plate detection using Modest AdaBoost and template matching

    Science.gov (United States)

    Sam, Kam Tong; Tian, Xiao Lin

    2010-02-01

    License plate detection and recognition are vital yet challenging tasks for law enforcement agencies. This paper presents a license plate detection prototype system for a Macao law enforcement department using Modest Adaboost combined with template matching technique. Firstly, a machine learning algorithm, based on Modest AdaBoost which mostly aims for better generalization capability and resistance to overfitting, was applied to find out candidate license plates over the input images. In the second stage, template matching technique was employed to verify the license plate appearances in order to reduce false positives. This paper shows that the AdaBoost algorithm, which was originally used for face detection, has successfully been applied to solve the problems of license plate detection. Experimental results demonstrate high accuracy and efficiency of the proposed method.

  12. Real-time multi-camera video acquisition and processing platform for ADAS

    Science.gov (United States)

    Saponara, Sergio

    2016-04-01

    The paper presents the design of a real-time and low-cost embedded system for image acquisition and processing in Advanced Driver Assisted Systems (ADAS). The system adopts a multi-camera architecture to provide a panoramic view of the objects surrounding the vehicle. Fish-eye lenses are used to achieve a large Field of View (FOV). Since they introduce radial distortion of the images projected on the sensors, a real-time algorithm for their correction is also implemented in a pre-processor. An FPGA-based hardware implementation, re-using IP macrocells for several ADAS algorithms, allows for real-time processing of input streams from VGA automotive CMOS cameras.

  13. Languages for artificial intelligence: Implementing a scheduler in LISP and in Ada

    Science.gov (United States)

    Hays, Dan

    1988-01-01

    A prototype scheduler for space experiments originally programmed in a dialect of LISP using some of the more traditional techniques of that language, was recast using an object-oriented LISP, Common LISP with Flavors on the Symbolics. This object-structured version was in turn partially implemented in Ada. The Flavors version showed a decided improvement in both speed of execution and readability of code. The recasting into Ada involved various practical problems of implementation as well as certain challenges of reconceptualization in going from one language to the other. Advantages were realized, however, in greater clarity of the code, especially where more standard flow of control was used. This exercise raised issues about the influence of programming language on the design of flexible and sensitive programs such as schedule planners, and called attention to the importance of factors external to the languages themselves such as system embeddedness, hardware context, and programmer practice.

  14. Digital data sets that describe aquifer characteristics of the Vamoosa-Ada aquifer in east-central Oklahoma

    Science.gov (United States)

    Abbott, Marvin M.; Runkle, D.L.; Rea, Alan

    1997-01-01

    Nonproprietary format files This diskette contains digitized aquifer boundaries and maps of hydraulic conductivity, recharge, and ground-water level elevation contours for the Vamoosa-Ada aquifer in east-central Oklahoma. The Vamoosa-Ada aquifer is an important source of water that underlies about 2,320-square miles of parts of Osage, Pawnee, Payne, Creek, Lincoln, Okfuskee, and Seminole Counties. Approximately 75 percent of the water withdrawn from the Vamoosa-Ada aquifer is for municipal use. Rural domestic use and water for stock animals account for most of the remaining water withdrawn. The Vamoosa-Ada aquifer is defined in a ground-water report as consisting principally of the rocks of the Late Pennsylvanian-age Vamoosa Formation and overlying Ada Group. The Vamoosa-Ada aquifer consists of a complex sequence of fine- to very fine-grained sandstone, siltstone, shale, and conglomerate interbedded with very thin limestones. The water-yielding capabilities of the aquifer are generally controlled by lateral and vertical distribution of the sandstone beds and their physical characteristics. The Vamoosa-Ada aquifer is unconfined where it outcrops in about an 1,700-square-mile area. Most of the lines in the aquifer boundary, hydraulic conductivity, and recharge data sets were extracted from published digital surficial geology data sets based on a scale of 1:250,000, and represent geologic contacts. Some of lines in the data sets were interpolated in areas where the Vamoosa-Ada aquifer is overlain by alluvial and terrace deposits near streams and rivers. These data sets include only the outcrop area of the Vamoosa-Ada aquifer and where the aquifer is overlain by alluvial and terrace deposits. The hydraulic conductivity value and recharge rate are from a ground-water report about the Vamoosa-Ada aquifer. The water-level elevation contours were digitized from a mylar map, at a scale of 1:250,000, used to publish a plate in a ground-water report about the Vamoosa-Ada

  15. Homozygosity for a novel adenosine deaminase (ADA) nonsense mutation (Q3>X) in a child with severe combined immunodeficiency (SCID)

    Energy Technology Data Exchange (ETDEWEB)

    Santisteban, I.; Arrendondo-Vega, F.X.; Kelly, S. [Duke Univ. Medical Center, Durham, NC (United States)]|[Hospital for Sick Children, Ontario (Canada)] [and others

    1994-09-01

    A Somali girl was diagnosed with ADA-deficient SCID at 7 mo; she responded well to PEG-ADA replacement and is now 3.3 yr old. ADA mRNA was undetectable (Northern) in her cultured T cells, but was present in T cells of her parents and two sibs. All PCR-amplified exon 1 genomic clones from the patient had a C>T transition at bp 7 relative to the start of translation, replacing Gln at codon 3 (AGA) with a termination codon (TGA, Q3>X). Patient cDNA (prepared by RT-PCR with a 5{prime} primer that covered codons 1-7) had a previously described polymorphism, K80>R, but was otherwise normal, indicating that no other coding mutations were present. A predicted new genomic BfaI restriction site was used to establish her homozygosity for Q3>X and to analyze genotypes of family members. We also analyzed the segregation of a variable Alu polyA-associated TAAA repeat (AluVpA) situated 5{prime} of the ADA gene. Three different AluVpA alleles were found, one of which was only present in the father and was not associated with his Q3>X allele. Because the father`s RBCs had only {approximately}15% of normal ADA activity, we analyzed his ADA cDNA. We found a G>A transition at bp 425 that substitutes Gln for Arg142, a solvent-accessible residue, and eliminates a BsmAI site in exon 5. ADA activity of the R142>Q in vitro translation product was 20-25% of wild type ADA translation product, suggesting that R142>Q is a new {open_quote}partial{close_quote} ADA deficiency mutation. As expected, Q3>X mRNA did not yield a detectable in vitro translation product. We conclude that the patient`s father is a compound heterozygote carrying the ADA Q3>X/R142>Q genotype. {open_quote}Partial{close_quote} ADA deficiency unassociated with immunodeficiency is relatively common in individuals of African descent. The present findings and previous observations suggest that {open_quote}partial{close_quote} ADA deficiency may have had an evolutionary advantage.

  16. Atrial natriuretic peptide in the locus coeruleus and its possible role in the regulation of arterial blood pressure, fluid and electrolyte homeostasis

    Energy Technology Data Exchange (ETDEWEB)

    Geiger, H.; Sterzel, R.B. (Univ. of Erlangen-Nuernberg (West Germany)); Bahner, U.; Heidland, A. (Univ. of Wuerzburg (West Germany)); Palkovits, M. (Semmelweis Univ., Budapest (Hungary))

    1991-01-01

    Atrial natriuretic factor (ANP) is present in neuronal cells of the locus coeruleus and its vicinity in the pontine tegmentum and moderate amount of ANP is detectable in this area by radioimmunoassay. The ANP is known as a neuropeptide which may influence the body salt and water homeostasis and blood pressure by targeting both central and peripheral regulatory mechanisms. Whether this pontine ANP cell group is involved in any of these regulatory mechanisms, the effect of various types of hypertension and experimental alterations in the salt and water balance on ANP levels was measured by radioimmunoassay in the locus coeruleus of rats. Adrenalectomy, as well as aldosterone and dexamethasone treatments failed to alter ANP levels in the locus coeruleus. Reduced ANP levels were measured in spontaneously hypertensive rats, and in diabetes insipidus rats with vasopressin replacement. In contrast to these situations, elevated ANP levels were found in rats with DOCA-salt or 1-Kidney-1-clip hypertension. These data suggest a link between ANP levels in the locus coeruleus and fluid volume homeostasis. Whether this link is causal and connected with the major activity of locus coeruleus neurons needs further information.

  17. SimWorx: An ADA Distributed Simulation Application Framework Supporting HLA and DIS

    Science.gov (United States)

    1996-12-01

    slightly different flavor from the analysis examples typically provided by methodologists (e.g., ATM machines, hydroponics experiment stations, robot...creativity free reign, yet kept me on track lest I strayed. He was a great mentor and made the positive difference in my AFIT academic experience . I...Distributed Interactive Simulation (DIS) standards. The goal was to create an Ada-based system for experimentation in distributed simulation. A subsidiary

  18. VIII Olimpíada Brasileira de Astronomia e Astronáutica

    Science.gov (United States)

    Garcia Canalle, João Batista; Villas da Rocha, Jaime Fernando; Wuensche de Souza, Carlos Alexandre; Pereira Ortiz, Roberto; Aguilera, Nuricel Villalonga; Padilha, Maria De Fátima Catta Preta; Pessoa Filho, José Bezerra; Soares Rodrigues, Ivette Maria

    2007-07-01

    Neste trabalho apresentamos as motivações pelas quais organizamos, em conjunto, pela primeira vez, a Olimpíada Brasileira de Astronomia incluindo a Astronáutica, em colaboração com a Agência Espacial Brasileira. Esta ampliação contribuiu para atrair ainda mais alunos, professores, escolas e patrocinadores para participarem desta Olimpíada. Em 2005 participaram da VIII Olimpíada Brasileira de Astronomia e Astronáutica (VIII OBA) 187.726 alunos distribuídos por 3.229 escolas, pertencentes a todos os estados brasileiros, incluindo o Distrito Federal. O crescimento em número de alunos participantes foi 52,4% maior do que em 2004. Em abril de 2005 organizamos, em Itapecerica da Serra, SP, um curso para os 50 alunos previamente selecionados e participantes da VII OBA e ao final selecionamos, dentre eles, uma equipe de 5 alunos, os quais representaram o Brasil na X Olimpíada Internacional de Astronomia, na China, em outubro de 2005. Ganhamos, pela primeira vez, uma medalha de ouro naquele evento. Em Agosto de 2005, organizamos a VIII Escola de Agosto para 50 alunos e respectivos professores, em Águas de Lindóia, SP, juntamente com a XXXI reunião anual da Sociedade Astronômica Brasileira (SAB). Em novembro de 2005 realizamos a I Jornada Espacial, em São José dos Campos, com 22 alunos e 22 professores selecionados dentre os participantes que melhores resultados obtiveram nas questões de Astronáutica da VIII OBA. Neste trabalho detalhamos os resultados da VIII OBA bem como as ações subseqüentes.

  19. Execução forçada das obrigações

    Directory of Open Access Journals (Sweden)

    João Máximo Rodrigues Neto

    2017-05-01

    Full Text Available O presente trabalho tem como escopo o estudo da execução forçada das obrigações e a evolução da tutela executiva ao longo dos anos, bem como aborda alguns pontos relacionados à teoria do inadimplemento. Tudo isso em uma ótica de prestígio da efetividade da prestação jurisdicional.

  20. Comparison of the diabetes guidelines from the ADA/EASD and the AACE/ACE.

    Science.gov (United States)

    Cornell, Susan

    To compare recent diabetes guideline updates from the American Diabetes Association-European Association for the Study of Diabetes (ADA/EASD) and the American Association of Clinical Endocrinologists-American College of Endocrinology (AACE/ACE). The ADA/EASD guideline continues to advocate a stepwise approach to glycemic control that initiates with metformin and intensifies treatment incrementally to dual and triple therapy at 3-month intervals until the patient is at their individualized goal. The AACE/ACE guideline provides a broader choice of first-line medications, with a suggested hierarchy of use, and it encourages initial dual and triple therapy if the glycated hemoglobin (A1C) level is high enough at diagnosis (7.5%-9.0% and >9.0%, respectively). Target A1C levels are higher in the ADA/EASD guideline (≤7.0%) compared with the AACE/ACE guideline (≤6.5%), although both statements indicate that targets should be adjusted to specific clinical scenarios based on safety. Both guidelines now include the new sodium-glucose cotransporter-2 inhibitors among their choices of acceptable glucose-lowering medications and endorse the overall cardiovascular and pancreatic safety of incretin therapies, and the safety of pioglitazone vis-a-vis bladder cancer. In practice, the ADA/EASD guidelines tend to be more user-friendly for general practitioners because of the simple stepwise intensification regimen, whereas the AACE/ACE guidelines are more commonly followed by specialists (endocrinologists) because of the more aggressive A1C targets. Copyright © 2017 American Pharmacists Association®. Published by Elsevier Inc. All rights reserved.

  1. An Assessment of Ada’s Suitability in General Purpose Programming Applications.

    Science.gov (United States)

    1985-09-01

    the solution is implemented at a lower level. 5. Information Hiding. To make inaccesible certain implementation details that should not affect other...NAATIONAL BUREAU OF STANDARDS - 96 3-A * - -- . . . . II AN ASSESSMENT OF ADA’S SUITABILITY IN GENERAL PURPOSE PROGRAMMING APPLICATIONS THES I S Larry D...accurate, and no sensitive items, detrimental ideas, or deleterious information are contained therein. Furthermore, the views expressed in the document are

  2. Ada (R) assessment: An important issue within European Columbus Support Technology Programme

    Science.gov (United States)

    Vielcanet, P.

    1986-01-01

    Software will be more important and more critical for Columbus than for any ESA previous project. As a simple comparison, overall software size has been in the range of 100 K source statements for EXOSAT, 500 K for Spacelab, and will probably reach several million lines of code for Columbus (all element together). Based on past experience, the total development cost of software can account for about 10 pct to 15 pct of the total space project development cost. The Ada technology may support the strong software engineering principles needed for Columbus, provided that technology is sufficiently mature and industry plans are meeting the Columbus project schedule. Over the past 3 years, Informatique Internationale has conducted a coherent program based on Ada technology assessment studies and experiments, for ESA and CNES. This specific research and development program benefits from 15 years experience in the field of space software development and is supported by the overall software engineering expertise of the company. The assessment and experiments of Ada software engineering by Informatique Internationale are detailed.

  3. Hiring discrimination against people with disabilities under the ADA: characteristics of charging parties.

    Science.gov (United States)

    McMahon, Brian T; Roessler, Richard; Rumrill, Philip D; Hurley, Jessica E; West, Steven L; Chan, Fong; Carlson, Linnea

    2008-06-01

    This article describes findings from a causal comparative study of the characteristics of Charging Parties who filed allegations of Hiring discrimination with the U.S. Equal Employment Opportunity Commission (EEOC) under Title I of the Americans with Disabilities Act (ADA) between 1992 and 2005. Charging Party Characteristics derived from 19,527 closed Hiring allegations are compared and contrasted to 259,680 closed allegations aggregated from six other prevalent forms of discrimination including Discharge and Constructive Discharge, Reasonable Accommodation, Disability Harassment and Intimidation, and Terms and Conditions of Employment. Tests of Proportion distributed as chi-square are used to form comparisons along a variety of factors including age, gender, impairment, and ethnicity. Most allegations of ADA job discrimination fall into the realm of job retention and career advancement as opposed to job acquisition. Hiring allegations, however, tend to be filed by Charging Parties who are disproportionately male, younger or older applicants, white, and coping with physical or sensory disabilities. Prevailing theories about stigma suggest that negative attitudes are more prevalent toward persons with behavioral disabilities. However, this study provides clear evidence that one behavioral manifestation of negative attitudes, Hiring discrimination, is more often directed at persons with physical or sensory impairments. More outreach regarding ADA rights appears indicated for individuals who share the aforementioned characteristics.

  4. The implementation and use of ADA on distributed systems with high reliability requirements

    Science.gov (United States)

    Knight, J. C.

    1985-01-01

    The use and implementation of Ada in distributed environments in which reliability is the primary concern is investigated. Emphasis is placed on the possibility that a distributed system may be programmed entirely in Ada so that the individual tasks of the system are unconcerned with which processors they are executing on, and that failures may occur in the software or underlying hardware. A new linguistic construct, the colloquy, is introduced which solves the problems identified in an earlier proposal, the conversation. It was shown that the colloquy is at least as powerful as recovery blocks, but it is also as powerful as all the other language facilities proposed for other situations requiring backward error recovery: recovery blocks, deadlines, generalized exception handlers, traditional conversations, s-conversations, and exchanges. The major features that distinguish the colloquy are described. Sample programs that were written, but not executed, using the colloquy show that extensive backward error recovery can be included in these programs simply and elegantly. These ideas are being implemented in an experimental Ada test bed.

  5. Using Ada to implement the operations management system in a community of experts

    Science.gov (United States)

    Frank, M. S.

    1986-01-01

    An architecture is described for the Space Station Operations Management System (OMS), consisting of a distributed expert system framework implemented in Ada. The motivation for such a scheme is based on the desire to integrate the very diverse elements of the OMS while taking maximum advantage of knowledge based systems technology. Part of the foundation of an Ada based distributed expert system was accomplished in the form of a proof of concept prototype for the KNOMES project (Knowledge-based Maintenance Expert System). This prototype successfully used concurrently active experts to accomplish monitoring and diagnosis for the Remote Manipulator System. The basic concept of this software architecture is named ACTORS for Ada Cognitive Task ORganization Scheme. It is when one considers the overall problem of integrating all of the OMS elements into a cooperative system that the AI solution stands out. By utilizing a distributed knowledge based system as the framework for OMS, it is possible to integrate those components which need to share information in an intelligent manner.

  6. 3 CFR - Regulatory Review

    Science.gov (United States)

    2010-01-01

    ... 3 The President 1 2010-01-01 2010-01-01 false Regulatory Review Presidential Documents Other Presidential Documents Memorandum of January 30, 2009 Regulatory Review Memorandum for the Heads of Executive Departments and Agencies For well over two decades, the Office of Information and Regulatory Affairs (OIRA) at...

  7. Ada Compiler Validation Summary Report: Certificate Number 890621I1. 10150 Intel Corporation/TARTAN Laboratories VMS Ada960MC Compiler R1.0 VAXstation 3200 to Intel 80060MC

    Science.gov (United States)

    1989-06-21

    set forth in this report are accurate and complete, or that the subject compiler has no nonconformities to the Ada Standard other than those presented...translators, and interpreters. Failed test An ACVC test for which the compiler generates a result that demonstrates nonconformity to the Ada Standard. Host...compilation files or not. A1408 and A1506 allow this behaviour . 1) Generic specifications and bodies can be compiled in separate compilations. (See tests

  8. Ada Compiler Validation Summary Report: DDC International A/S, DDC-I Ada Compiler System, Version 4.1.1, DEC VAX-11 Model 8530 (Host and Target)

    Science.gov (United States)

    1987-12-16

    are accurate and complete, or that the subject compiler has no nonconformities 0 to the Ada Standard other than those presented. Copies of this report...result that I demonstrates nonconformity to the Ada Standard. host The computer on which the compiler resides. - Inapplicable An ACVC test that uses...fields. It opens for modifications of the behaviour re- quired by the Arm, such as being able to open a file for appending data to it. Furthermore, a

  9. Automated Detection of Driver Fatigue Based on AdaBoost Classifier with EEG Signals

    Directory of Open Access Journals (Sweden)

    Jianfeng Hu

    2017-08-01

    Full Text Available Purpose: Driving fatigue has become one of the important causes of road accidents, there are many researches to analyze driver fatigue. EEG is becoming increasingly useful in the measuring fatigue state. Manual interpretation of EEG signals is impossible, so an effective method for automatic detection of EEG signals is crucial needed.Method: In order to evaluate the complex, unstable, and non-linear characteristics of EEG signals, four feature sets were computed from EEG signals, in which fuzzy entropy (FE, sample entropy (SE, approximate Entropy (AE, spectral entropy (PE, and combined entropies (FE + SE + AE + PE were included. All these feature sets were used as the input vectors of AdaBoost classifier, a boosting method which is fast and highly accurate. To assess our method, several experiments including parameter setting and classifier comparison were conducted on 28 subjects. For comparison, Decision Trees (DT, Support Vector Machine (SVM and Naive Bayes (NB classifiers are used.Results: The proposed method (combination of FE and AdaBoost yields superior performance than other schemes. Using FE feature extractor, AdaBoost achieves improved area (AUC under the receiver operating curve of 0.994, error rate (ERR of 0.024, Precision of 0.969, Recall of 0.984, F1 score of 0.976, and Matthews correlation coefficient (MCC of 0.952, compared to SVM (ERR at 0.035, Precision of 0.957, Recall of 0.974, F1 score of 0.966, and MCC of 0.930 with AUC of 0.990, DT (ERR at 0.142, Precision of 0.857, Recall of 0.859, F1 score of 0.966, and MCC of 0.716 with AUC of 0.916 and NB (ERR at 0.405, Precision of 0.646, Recall of 0.434, F1 score of 0.519, and MCC of 0.203 with AUC of 0.606. It shows that the FE feature set and combined feature set outperform other feature sets. AdaBoost seems to have better robustness against changes of ratio of test samples for all samples and number of subjects, which might therefore aid in the real-time detection of driver

  10. Locus of control and online learning

    Directory of Open Access Journals (Sweden)

    Suretha Esterhuysen

    2004-10-01

    Full Text Available The integration of online learning in university courses is considered to be both inevitable and necessary. Thus there is an increasing need to raise awareness among educators and course designers about the critical issues impacting on online learning. The aim of this study, therefore, was to assess the differences between two groups of first-year Business Sciences learners (online and conventional learners in terms of biographic and demographic characteristics and locus of control. The study population consisted of 586 first-year learners of whom 185 completed the Locus of Control Inventory (LCI. The results show that the two groups of learners do not differ statistically significantly from each other with respect to locus of control. The findings and their implications are also discussed. Opsomming Die integrasie van aanlyn-leer in universiteitskursusse word beskou as sowel onafwendbaar as noodsaaklik. Daar is dus ’n toenemende behoefte om bewustheid onder opvoedkundiges en kursusontwerpers te kweek oor die kritiese aspekte wat ’n impak op aanlyn-leer het (Morgan, 1996. Daarom was die doel van hierdie ondersoek om die verskille tussen twee groepe eerstejaarleerders in Bestuurs- en Ekonomiese Wetenskap (aanlyn en konvensionele leerders te bepaal ten opsigte van biografiese en demografiese eienskappe en lokus van beheer. Die populasie het bestaan uit 586 eerstejaarleerders waarvan 185 die Lokus van Beheer Vraelys voltooi het. Die resultate toon dat die twee groepe leerders nie statisties beduidend van mekaar verskil het met betrekking tot lokus van beheer nie. Die bevindinge en implikasies word ook bespreek.

  11. EsrE-A yigP Locus-Encoded Transcript-Is a 3′ UTR sRNA Involved in the Respiratory Chain of E. coli

    Directory of Open Access Journals (Sweden)

    Hui Xia

    2017-08-01

    Full Text Available The yigP locus is widely conserved among γ-proteobacteria. Mutation of the yigP locus impacts aerobic growth of Gram-negative bacteria. However, the underlying mechanism of how the yigP locus influences aerobic growth remains largely unknown. Here, we demonstrated that the yigP locus in Escherichia coli encodes two transcripts; the mRNA of ubiquinone biosynthesis protein, UbiJ, and the 3′ untranslated region small regulatory RNA (sRNA, EsrE. EsrE is an independent transcript that is transcribed using an internal promoter of the yigP locus. Surprisingly, we found that both the EsrE sRNA and UbiJ protein were required for Q8 biosynthesis, and were sufficient to rescue the growth defect ascribed to deletion of the yigP locus. Moreover, our data showed that EsrE targeted multiple mRNAs involved in several cellular processes including murein biosynthesis and the tricarboxylic acid cycle. Among these targets, sdhD mRNA that encodes one subunit of succinate dehydrogenase (SDH, was significantly activated. Our findings provided an insight into the important function of EsrE in bacterial adaptation to various environments, as well as coordinating different aspects of bacterial physiology.

  12. Cut Locus Construction using Deformable Simplicial Complexes

    DEFF Research Database (Denmark)

    Misztal, Marek Krzysztof; Bærentzen, Jakob Andreas; Anton, François

    2011-01-01

    In this paper we present a method for appproximating cut loci for a given point p on Riemannian 2D manifolds, closely related to the notion of Voronoi diagrams. Our method finds the cut locus by advecting a front of points equally distant from p along the geodesics originating at p and finding th...... the domain to have disk topology. We test our method for tori of revolution and compare our results to the benchmark ones from [2]. The method, however, is generic and can be easily adapted to construct cut loci for other manifolds of genera other than 1....

  13. An empirical assessment of the construct "work locus of control"

    Directory of Open Access Journals (Sweden)

    Allan Maram

    1998-06-01

    Full Text Available This study is concerned with the domain specificity of the locus of control construct within the workplace. The research investigated whether Specter's (1988 work locus of control scale, a work centred conceptualisation of Rotter's (1966 locus of control measure/ demonstrated evidence of criterion - related validity. This was done by assessing its relationship to leader-member exchange and organisational commitment. The results indicated that work locus of control correlated with both leader-member exchange and organisational commitment and that leadermember exchange acted as a mediator of the relationship between work locus of control and organisational commitment. This is consistent with results from a similar study undertaken by Kinicki & Vecchio (1994 who employed Rotter's (1966 general locus of control measure. The current research demonstrated stronger relationship than Kinicki & Vecchio's (1994 study, which suggests that Specter's (1988 domain specific scale may predict work behaviour more precisely than Rotter's (1966 more general measure.

  14. Locus of boundary crisis: expect infinitely many gaps.

    Science.gov (United States)

    Osinga, Hinke M

    2006-09-01

    Boundary crisis is a mechanism for destroying a chaotic attractor when one parameter is varied. In a two-parameter setting the locus of the boundary crisis is associated with curves of homoclinic or heteroclinic bifurcations of periodic saddle points. It is known that this locus has nondifferentiable points. We show here that the locus of boundary crisis is far more complicated than previously reported. It actually contains infinitely many gaps, corresponding to regions (of positive measure) where attractors exist.

  15. Implementación de un framework de componente en el lenguaje de programación Ada

    OpenAIRE

    Hernández Villalón, Francisco José

    2013-01-01

    El objetivo principal de este proyecto es la traducción de FrameworkAda 2005 y mantener la compatibilidad entre las dos implementaciones de Framework que se realizaron anteriormente C++ y Java. Cabe destacar que la implementación en Java es el Framework de partida de donde derivan estas dos últimas C++ y Ada 2005. Escuela Técnica Superior de Ingeniería Industrial Universidad Politécnica de Cartagena

  16. Annual ASEET (Ada Software Engineering Education and Training) Symposium (SLIDES) Held in Dallas, TX. on 9-11 June 1987.

    Science.gov (United States)

    1987-06-11

    University of New Orleans (UNO) started implementing the programming language Ada as the departamental language. This paper is a personal report of this 3...year effort. 0 .?.’. ? Structure of lecture. University Setting. 0 Departamental Setting Curriculum overview. Ada as a Primary Programming Language...third course no more than a 25% . attrition rate when Pascal was the departamental programming language. Many students drop the class due to the fact

  17. Impact of locus of control on health message effectiveness.

    Science.gov (United States)

    Kong, Ying; Shen, Fuyuan

    2011-10-01

    This article examined how individuals' locus of control might moderate the effect of health message frames. An experiment was conducted whereby participants read either individual- or social-responsibility message frames after their locus of control was primed. Results indicated that messages presented in individual-responsibility frames were more persuasive when people were primed with internal locus of control, whereas social-responsibility framed appeals were more persuasive when people were primed with external locus of control. These results were found for individuals in both high and low cognitive load conditions. Theoretical and practical implications of the findings are discussed.

  18. Biochemical detection of E-ADA on Neospora caninum tachyzoites and the effects of a specific enzymatic inhibitor

    Directory of Open Access Journals (Sweden)

    Alexandre A. Tonin

    2015-01-01

    Full Text Available Objective. This study aimed to investigate the presence and activity of the ecto adenosine deaminase (E-ADA enzyme in tachyzoites of Neospora caninum (Nc-1 strain, as well as to assess the activity of a well-known E-ADA inhibitor, the deoxycoformycin. Materials and methods. The parasites were grown in cell culture, being subsequently separated in a pellet of tachyzoites, on which the E-ADA activity was tested using the concentrations 0 (control, 0.2, 0.4 and 0.8 mg mL-1. Results. The E-ADA showed high activity, progressively increasing its activity according to the enhancement of the protein concentration. The test was carried out with different concentrations of deoxycoformycin, showing that it was able to inhibit the E-ADA present on the free form of the parasite. Conclusions. Based on these results we conclude that the E-ADA is present on tachyzoites of N. caninum, and deoxycoformycin is able to inhibit this enzyme. In this sense, knowing the negative impact of N. caninum on reproductive issue in cattle (mainly abortion, might it is an alternative in order to deal with this parasitic infection.

  19. Beyond the locus of spectrally pure colors

    Science.gov (United States)

    Fairchild, Mark D.

    2008-01-01

    The spectrum locus of a CIE chromaticity diagram defines the boundary within which all physically realizable color stimuli must fall. While that is a physical and mathematical reality that cannot be violated, it is possible to create colors that appear as if they were produced by physically impossible stimuli. This can be accomplished through careful control of the viewing conditions and states of adaptation. This paper highlights the importance of considering color appearance issues in the design of displays and specification of color gamuts and illustrates how the perceived color gamut can be manipulated significantly through the relationship between white-point and primary luminance levels without changing the chromaticity gamut of a display system. Using a color appearance model, such as CIECAM02, display color gamuts can be specified in perceptual terms such as lightness, chroma, brightness, and colorfulness rather than in strictly physical terms of the stimuli that create these perceptions. Examination of these perceptual gamuts, and their relationships to the viewing conditions, allows demonstration of the possibility of producing display gamuts that appear to reach beyond the locus of pure spectral colors when compared with typical display setups.

  20. Evolution of the mating type locus: insights gained from the dimorphic primary fungal pathogens Histoplasma capsulatum, Coccidioides immitis, and Coccidioides posadasii.

    Science.gov (United States)

    Fraser, James A; Stajich, Jason E; Tarcha, Eric J; Cole, Garry T; Inglis, Diane O; Sil, Anita; Heitman, Joseph

    2007-04-01

    Sexual reproduction of fungi is governed by the mating type (MAT) locus, a specialized region of the genome encoding key transcriptional regulators that direct regulatory networks to specify cell identity and fate. Knowledge of MAT locus structure and evolution has been considerably advanced in recent years as a result of genomic analyses that enable the definition of MAT locus sequences in many species as well as provide an understanding of the evolutionary plasticity of this unique region of the genome. Here, we extend this analysis to define the mating type locus of three dimorphic primary human fungal pathogens, Histoplasma capsulatum, Coccidioides immitis, and Coccidioides posadasii, using genomic analysis, direct sequencing, and bioinformatics. These studies provide evidence that all three species possess heterothallic bipolar mating type systems, with isolates encoding either a high-mobility-group (HMG) domain or an alpha-box transcriptional regulator. These genes are intact in all loci examined and have not been subject to loss or decay, providing evidence that the loss of fertility upon passage in H. capsulatum is not attributable to mutations at the MAT locus. These findings also suggest that an extant sexual cycle remains to be defined in both Coccidioides species, in accord with population genetic evidence. Based on these MAT sequences, a facile PCR test was developed that allows the mating type to be rapidly ascertained. Finally, these studies highlight the evolutionary forces shaping the MAT locus, revealing examples in which flanking genes have been inverted or subsumed and incorporated into an expanding MAT locus, allowing us to propose an expanded model for the evolution of the MAT locus in the phylum Ascomycota.

  1. Evolution of the Mating Type Locus: Insights Gained from the Dimorphic Primary Fungal Pathogens Histoplasma capsulatum, Coccidioides immitis, and Coccidioides posadasii▿ †

    Science.gov (United States)

    Fraser, James A.; Stajich, Jason E.; Tarcha, Eric J.; Cole, Garry T.; Inglis, Diane O.; Sil, Anita; Heitman, Joseph

    2007-01-01

    Sexual reproduction of fungi is governed by the mating type (MAT) locus, a specialized region of the genome encoding key transcriptional regulators that direct regulatory networks to specify cell identity and fate. Knowledge of MAT locus structure and evolution has been considerably advanced in recent years as a result of genomic analyses that enable the definition of MAT locus sequences in many species as well as provide an understanding of the evolutionary plasticity of this unique region of the genome. Here, we extend this analysis to define the mating type locus of three dimorphic primary human fungal pathogens, Histoplasma capsulatum, Coccidioides immitis, and Coccidioides posadasii, using genomic analysis, direct sequencing, and bioinformatics. These studies provide evidence that all three species possess heterothallic bipolar mating type systems, with isolates encoding either a high-mobility-group (HMG) domain or an α-box transcriptional regulator. These genes are intact in all loci examined and have not been subject to loss or decay, providing evidence that the loss of fertility upon passage in H. capsulatum is not attributable to mutations at the MAT locus. These findings also suggest that an extant sexual cycle remains to be defined in both Coccidioides species, in accord with population genetic evidence. Based on these MAT sequences, a facile PCR test was developed that allows the mating type to be rapidly ascertained. Finally, these studies highlight the evolutionary forces shaping the MAT locus, revealing examples in which flanking genes have been inverted or subsumed and incorporated into an expanding MAT locus, allowing us to propose an expanded model for the evolution of the MAT locus in the phylum Ascomycota. PMID:17337636

  2. Cohesin is required for higher-order chromatin conformation at the imprinted IGF2-H19 locus.

    Directory of Open Access Journals (Sweden)

    Raffaella Nativio

    2009-11-01

    Full Text Available Cohesin is a chromatin-associated protein complex that mediates sister chromatid cohesion by connecting replicated DNA molecules. Cohesin also has important roles in gene regulation, but the mechanistic basis of this function is poorly understood. In mammalian genomes, cohesin co-localizes with CCCTC binding factor (CTCF, a zinc finger protein implicated in multiple gene regulatory events. At the imprinted IGF2-H19 locus, CTCF plays an important role in organizing allele-specific higher-order chromatin conformation and functions as an enhancer blocking transcriptional insulator. Here we have used chromosome conformation capture (3C assays and RNAi-mediated depletion of cohesin to address whether cohesin affects higher order chromatin conformation at the IGF2-H19 locus in human cells. Our data show that cohesin has a critical role in maintaining CTCF-mediated chromatin conformation at the locus and that disruption of this conformation coincides with changes in IGF2 expression. We show that the cohesin-dependent, higher-order chromatin conformation of the locus exists in both G1 and G2 phases of the cell cycle and is therefore independent of cohesin's function in sister chromatid cohesion. We propose that cohesin can mediate interactions between DNA molecules in cis to insulate genes through the formation of chromatin loops, analogous to the cohesin mediated interaction with sister chromatids in trans to establish cohesion.

  3. Data set for comparison of cellular dynamics between human AAVS1 locus-modified and wild-type cells

    Directory of Open Access Journals (Sweden)

    Takeomi Mizutani

    2016-03-01

    Full Text Available This data article describes cellular dynamics, such as migration speed and mobility of the cytoskeletal protein, of wild-type human fibroblast cells and cells with a modified adeno-associated virus integration site 1 (AAVS1 locus on human chromosome 19. Insertion of exogenous gene into the AAVS1 locus has been conducted in recent biological researches. Previously, our data showed that the AAVS1-modification changes cellular contractile force (Mizutani et al., 2015 [1]. To assess if this AAVS1-modification affects cell migration, we compared cellular migration speed and turnover of cytoskeletal protein in human fibroblasts and fibroblasts with a green fluorescent protein gene knocked-in at the AAVS1 locus in this data article. Cell nuclei were stained and changes in their position attributable to cell migration were analyzed. Fluorescence recovery was observed after photobleaching for the fluorescent protein-tagged myosin regulatory light chain. Data here are related to the research article “Transgene Integration into the Human AAVS1 Locus Enhances Myosin II-Dependent Contractile Force by Reducing Expression of Myosin Binding Subunit 85” [1].

  4. Molecular characterization of the singed wings locus of Drosophila melanogaster

    Directory of Open Access Journals (Sweden)

    Boykova Tatiana

    2004-06-01

    Full Text Available Abstract Background Hormones frequently guide animal development via the induction of cascades of gene activities, whose products further amplify an initial hormonal stimulus. In Drosophila the transformation of the larva into the pupa and the subsequent metamorphosis to the adult stage is triggered by changes in the titer of the steroid hormone 20-hydroxyecdysone. singed wings (swi is the only gene known in Drosophila melanogaster for which mutations specifically interrupt the transmission of the regulatory signal from early to late ecdysone inducible genes. Results We have characterized singed wings locus, showing it to correspond to EG:171E4.2 (CG3095. swi encodes a predicted 68.5-kDa protein that contains N-terminal histidine-rich and threonine-rich domains, a cysteine-rich C-terminal region and two leucine-rich repeats. The SWI protein has a close homolog in D. melanogaster, defining a new family of SWI-like proteins, and is conserved in D. pseudoobscura. A lethal mutation, swit476, shows a severe disruption of the ecdysone pathway and is a C>Y substitution in one of the two conserved CysXCys motifs that are common to SWI and the Drosophila Toll-4 protein. Conclusions It is not entirely clear from the present molecular analysis how the SWI protein may function in the ecdysone induced cascade. Currently all predictions agree in that SWI is very unlikely to be a nuclear protein. Thus it probably exercises its control of "late" ecdysone genes indirectly. Apparently the genetic regulation of ecdysone signaling is much more complex then was previously anticipated.

  5. Locus-specific ribosomal RNA gene silencing in nucleolar dominance.

    Directory of Open Access Journals (Sweden)

    Michelle S Lewis

    2007-08-01

    Full Text Available The silencing of one parental set of rRNA genes in a genetic hybrid is an epigenetic phenomenon known as nucleolar dominance. We showed previously that silencing is restricted to the nucleolus organizer regions (NORs, the loci where rRNA genes are tandemly arrayed, and does not spread to or from neighboring protein-coding genes. One hypothesis is that nucleolar dominance is the net result of hundreds of silencing events acting one rRNA gene at a time. A prediction of this hypothesis is that rRNA gene silencing should occur independent of chromosomal location. An alternative hypothesis is that the regulatory unit in nucleolar dominance is the NOR, rather than each individual rRNA gene, in which case NOR localization may be essential for rRNA gene silencing. To test these alternative hypotheses, we examined the fates of rRNA transgenes integrated at ectopic locations. The transgenes were accurately transcribed in all independent transgenic Arabidopsis thaliana lines tested, indicating that NOR localization is not required for rRNA gene expression. Upon crossing the transgenic A. thaliana lines as ovule parents with A. lyrata to form F1 hybrids, a new system for the study of nucleolar dominance, the endogenous rRNA genes located within the A. thaliana NORs are silenced. However, rRNA transgenes escaped silencing in multiple independent hybrids. Collectively, our data suggest that rRNA gene activation can occur in a gene-autonomous fashion, independent of chromosomal location, whereas rRNA gene silencing in nucleolar dominance is locus-dependent.

  6. Libertad soñada y libertad concreta en la época ilustrada

    OpenAIRE

    Bello Reguera, Eduardo

    1994-01-01

    ¿Ha inventado la libertad el siglo XVIII? El análisis, que podría hacerse desde la triple experiencia de la libertad artística, "libertina" y política, se limita aquí al examen de esta última tanto desde la perspectiva de la Revolución Gloriosa teorizada por Locke en Two Essays of Government, como desde la experiencia de la Revolución Francesa, anticipada teóricamente en Du contrat social, así como desde la perspectiva de la "meta soñada" prevista por Kant. Is freedom an XVIIIth Century in...

  7. WIS (WWMCCS (World Wide Military Command and Control System) Information System) Ada (Trade Name) Translator Testing.

    Science.gov (United States)

    1987-04-01

    aSOs psasen nus Af ais usuiaiiad a n M " hplaad"oda mew busiuft" udsppou aiuI~c le mM~ aulai paau " Iaa -ab adps lolov aool ofIUusru VIand pod asbdIs...Syntax Tree (AAST). 2 * b. FORTRAN Tree Transformer - transforms the FORTRAN AAST into Descriptive Intermediate Attributed Notation for Ada (DIANA). o...COBOL Source Analyzer - analyzes WWMCCS ADP COBOL source and creates an AAST. * d. COBOL Tree Transformer - transforms the COBOL AAST into DIANA. e

  8. KAPSE (Kernel ADA Programming Support Environment) Interface Team Public Report. Volume 5.

    Science.gov (United States)

    1985-08-01

    vague in certain areas and totally lacking in others. F.)r examr.le, aCAIE that is "upwards compatible" would be great but do we know enough now io...lattend. Herm reviewed the previously voted issues and discussed the benefits of a "CAISd S "UNIX" implementation which could be accomplished in various...the benefit gained was judged not to warrant the cost. The suggestion ws made that proeses might need an analogy to - the terminate alternative for Ada

  9. Ship detection in optical remote sensing image based on visual saliency and AdaBoost classifier

    Science.gov (United States)

    Wang, Hui-li; Zhu, Ming; Lin, Chun-bo; Chen, Dian-bing

    2017-03-01

    In this paper, firstly, target candidate regions are extracted by combining maximum symmetric surround saliency detection algorithm with a cellular automata dynamic evolution model. Secondly, an eigenvector independent of the ship target size is constructed by combining the shape feature with ship histogram of oriented gradient (S-HOG) feature, and the target can be recognized by AdaBoost classifier. As demonstrated in our experiments, the proposed method with the detection accuracy of over 96% outperforms the state-of-the-art method.

  10. Achieving high recognition reliability using decision trees and AdaBoost

    Science.gov (United States)

    Xiang, Jianying; Tu, Xiao; Lu, Yue; Wang, Patrick S. P.

    2008-01-01

    Recognition rate is traditionally used as the main criterion for evaluating the performance of a recognition system. High recognition reliability with low misclassification rate is also a must for many applications. To handle the variability of the writing style of different individuals, this paper employs decision trees and WRB AdaBoost to design a classifier with high recognition reliability for recognizing Bangla handwritten numerals. Experiments on the numeral images obtained from real Bangladesh envelopes show that the proposed recognition method is capable of achieving high recognition reliability with acceptable recognition rate.

  11. An Ada Linear-Algebra Software Package Modeled After HAL/S

    Science.gov (United States)

    Klumpp, Allan R.; Lawson, Charles L.

    1990-01-01

    New avionics software written more easily. Software package extends Ada programming language to include linear-algebra capabilities similar to those of HAL/S programming language. Designed for such avionics applications as Space Station flight software. In addition to built-in functions of HAL/S, package incorporates quaternion functions used in Space Shuttle and Galileo projects and routines from LINPAK solving systems of equations involving general square matrices. Contains two generic programs: one for floating-point computations and one for integer computations. Written on IBM/AT personal computer running under PC DOS, v.3.1.

  12. A Study of the Feasibility of Duplicating JAMPS Applications Software in the Ada Programming Language.

    Science.gov (United States)

    1984-04-01

    the Sieve of 33 Eratosthenes 4 Sizing Analysis for Existing Software Written in "C" 44 5 Sizing Data with Adjustments 45 6 Conversion from "C" to Ada...benchmark program based on the Sieve of EratoSthenes [7 ]. This program finds all of the prime numbers between 3 and 16381. The benchmark test results shown in...appears to be quite reasonable for the JAMPS application. 32 - Table 3 Benchmark Test Results Using the Sieve of Eratosthenes [7 ] Execution Operating Time

  13. Resultados del tratamiento a pacientes con tríada terrible del codo

    OpenAIRE

    Héctor Gabriel Díaz Carrillo; William Álvarez Consuegra; Michel Quevedo Pérez

    2015-01-01

    La luxación del codo, asociada a la fractura del proceso coronoideo y a la fractura de la cabeza radial, es denominada “tríada terrible del codo”, debido a la complejidad al abordar el tratamiento correcto y lo desalentador de los resultados que se obtienen con el mismo. Se realizó un estudio prospectivo, donde se recogen los resultados postoperatorios, obtenidos en cuatro pacientes con inestabilidad traumática aguda del codo, tratados entre enero de 2012 y mayo de 2013, que acudieron inicial...

  14. Development of Ada language control software for the NASA power management and distribution test bed

    Science.gov (United States)

    Wright, Ted; Mackin, Michael; Gantose, Dave

    1989-01-01

    The Ada language software developed to control the NASA Lewis Research Center's Power Management and Distribution testbed is described. The testbed is a reduced-scale prototype of the electric power system to be used on space station Freedom. It is designed to develop and test hardware and software for a 20-kHz power distribution system. The distributed, multiprocessor, testbed control system has an easy-to-use operator interface with an understandable English-text format. A simple interface for algorithm writers that uses the same commands as the operator interface is provided, encouraging interactive exploration of the system.

  15. Americans With Disabilities Act (ADA) Accessibility Guidelines for Transportation Vehicles. Final rule.

    Science.gov (United States)

    2016-12-14

    The Architectural and Transportation Barriers Compliance Board (Access Board or Board) is issuing a final rule that revises its existing accessibility guidelines for non-rail vehicles--namely, buses, over-the-road buses, and vans--acquired or remanufactured by entities covered by the Americans with Disabilities Act. The revised guidelines ensure that such vehicles are readily accessible to, and usable by, individuals with disabilities. The U.S. Department of Transportation (DOT) is required to revise its accessibility standards for transportation vehicles acquired or remanufactured by entities covered by the Americans with Disabilities Act (ADA) to be consistent with the final rule.

  16. Continued Development of the JOVIAL(J73) to Ada Translator system.

    Science.gov (United States)

    1981-12-01

    bottom-up table driven LR (1) parser and builds a parse tree. The J73 parse tree is then transformed into an equivalent Ada parse tree. Finally a pretty...accomplished using a table driven bottom-up LR (1) parser . A parser is some mechanism capable of determining if a construct (string) belongs to a particular...grammar (language). Parsers are usually contained in two broad classes: top-down and bottom-up (Ref 5:46-47). The " LR " means Left-to-right, Right

  17. Argamassa Reforçada com Armadura Difusa de Aço

    Directory of Open Access Journals (Sweden)

    José Eduardo Fairbanks Nascimbeni

    1990-12-01

    Full Text Available Apresenta métodos de ensaio, resultados e conclusões de experimentos controlados em corpos de prova e peças de argamassa reforçada com fibras de aço, como armadura difusa, São abordadas considerações teóricas sobre as condições gerais de ruptura e sobre as interferências fibra/matriz. Concluiu-se haver viabilidade técnica no uso do compósito, quanto à resistência à flexão

  18. Regulatory Information By Sector

    Science.gov (United States)

    Find environmental regulatory, compliance, & enforcement information for various business, industry and government sectors, listed by NAICS code. Sectors include agriculture, automotive, petroleum manufacturing, oil & gas extraction & other manufacturing

  19. Locus - ASTRA | LSDB Archive [Life Science Database Archive metadata

    Lifescience Database Archive (English)

    Full Text Available switchLanguage; BLAST Search Image Search Home About Archive Update History Data ...URL: ftp://ftp.biosciencedbc.jp/archive/astra/LATEST/astra_locus.zip File size: 887 KB Simple search URL htt...icing type (ex. cassette) About This Database Database Description Download License Update History of This Database Site Policy | Contact Us Locus - ASTRA | LSDB Archive ...

  20. Locus of Control and Its Affect on Achievement.

    Science.gov (United States)

    Tomlinson, Louise M.

    Locus of control is considered a primary factor in the difference between students' high and low achievement. This phenomenon is defined as a polar construct which refers to the degree to which individuals view their successes and failures as either contingent upon their own behaviors (internal locus of control) or independent of them (external…

  1. Metacognition: As a Predictor of One's Academic Locus of Control

    Science.gov (United States)

    Arslan, Serhat; Akin, Ahmet

    2014-01-01

    The purpose of this study is to examine the effect of metacognition on one's academic locus of control. The study's sample group consists of 451 university students enrolled in various programs at Sakarya University, Turkey. In this study, the Metacognitive Awareness Inventory and the Academic Locus of Control Scale were used. The correlations and…

  2. Changing Locus of Control: Steelworkers Adjusting to Forced Unemployment

    Science.gov (United States)

    Legerski, Elizabeth Miklya; Cornwall, Marie; O'Neil, Brock

    2006-01-01

    Using an abbreviated version of Levenson's (1981) locus of control scale, we examine change over time in the locus of control of displaced steelworkers. The first data collection occurred approximately six months after plant shutdown, the second occurred a year later. Utilizing a multidimensional measurement model, we test the major assumption…

  3. Locus of control and investment in risky assets

    NARCIS (Netherlands)

    Salamanca, N.; de Grip, A.; Fouarge, D.; Montizaan, R.M.

    2013-01-01

    Using representative household panel data, we show that the investment behavior of households is related to the economic locus of control of household heads. A household's internal locus of control in economic issues is positively related to its decision to hold risky assets as well as its share of

  4. Pharmacists as Entrepreneurs or Employees: The Role of Locus of ...

    African Journals Online (AJOL)

    Purpose: To investigate whether locus of control distinguished between pharmacists who chose to become entrepreneurs and those who took up employee roles in pharmaceutical establishments. Methods: The enlarged version of Rotter's I-E scale designed to measure an individual's locus of control was used to survey a ...

  5. A new strategy for estimating two-locus recombination fractions ...

    Indian Academy of Sciences (India)

    Linkage analysis is now being widely used to map markers on each chromosome in the human genome, to map genetic diseases, and to identify genetic forms of common diseases. Two-locus linkage analysis and multi-locus analysis have been investigated comprehensively, and many computer programs have been ...

  6. Nucleotide variation at the methionine synthase locus in an ...

    African Journals Online (AJOL)

    Nucleotide variation at the methionine synthase (MetE) locus within and among populations of an endangered forest tree Fokienia hodginsii in Vietnam was investigated in the present study. A total of 12 populations were sampled across Vietnam. The length of the sequenced locus varied from 1567 to 1559 bp. A total of 42 ...

  7. Health Beliefs and Locus of Control as Predictors of Cancer ...

    African Journals Online (AJOL)

    OR= 0.35, p < 0.05), internal locus of control (OR = 1.43, p < 0.05) and health risks behaviour (OR= 0.42, p < 0.05) all significantly predicted cervical cancer screening behaviour of women. Keywords: Health beliefs, Health locus of control, cancer ...

  8. Pharmacists as Entrepreneurs or Employees: The Role of Locus of ...

    African Journals Online (AJOL)

    Patrick Erah

    Methods: The enlarged version of Rotter's I-E scale designed to measure an individual's locus of ..... Research Instrument: The instrument used to .... qualified pharmacists who chose to become entrepreneurs and those who chose employee status in organisations. Those who showed more locus of control internality are ...

  9. Is this Red Spot the Blue Spot (locus ceruleum)?

    Energy Technology Data Exchange (ETDEWEB)

    Choe, Won Sick; Lee, Yu Kyung; Lee, Min Kyung; Hwang, Kyung Hoon [Gachon University Gil Hospital, Incheon (Korea, Republic of)

    2010-06-15

    The authors report brain images of 18F-FDG-PET in a case of schizophrenia. The images showed strikingly increased bilateral uptake in the locus ceruleum. The locus ceruleum is called the blue spot and known to be a center of the norepinephrinergic system.

  10. The Role of Locus of Control in Leader Influence Behavior.

    Science.gov (United States)

    Johnson, Avis L.; And Others

    1984-01-01

    Investigated whether leader's (N=89) locus of control moderated the relationship between perceived leader influence behaviors and certain subordinate (N=245) outcome variables. The results showed that locus of control did significantly moderate the effect of supervisor influence on productivity and subordinate satisfaction with supervision. (JAC)

  11. The relationship between internal and external locus of control of ...

    African Journals Online (AJOL)

    The method of this study was descriptive and correlational type. The statistic population in this study included parents of children, male and ... Research samples were assessed by using questionnaires Rutter locus of control and aggression. The results of the analysis showed that there is relationship between internal locus ...

  12. Personality and Locus of Control among School Children

    Science.gov (United States)

    Pandya, Archana A.; Jogsan, Yogesh A.

    2013-01-01

    The main purpose of this investigation is to find out the sex differences in personality traits and locus of control among school children. A total 60 children (30 boys and 30 girls) were taken as a sample. The research tool for personality, children personality questionnaire was used, which was made by Cattell and Porter. Locus of control was…

  13. Turkish population data on the short tandem repeat locus TPOX

    DEFF Research Database (Denmark)

    Vural, B; Poda, M; Atlioglu, E

    1998-01-01

    Allele and genotype frequencies were determined for the STR (short tandem repeat) locus TPOX in a random Turkish population sample of 200 individuals.......Allele and genotype frequencies were determined for the STR (short tandem repeat) locus TPOX in a random Turkish population sample of 200 individuals....

  14. Escala de Locus de controle ELCO/TELEBRÁS Scale of Locus of control - ELCO

    Directory of Open Access Journals (Sweden)

    Luiz Pasquali

    1998-01-01

    Full Text Available Com base na teoria de Rotter e Escala de Levenson foi elaborada uma escala de Locus de Controle Organizacional (ELCO, composta por 28 itens. A escala foi validada com uma amostra de 350 empregados do Sistema Telebrás. Verificou-se a presença dos 2 fatores previstos na teoria, a saber: internalidade e externalidade, aparecendo a escala de externalidade, com 18 itens, bem estruturada (alfa = 0.81 e a de internalidade, com 10 itens, deixando a desejar no que se refere à consistência interna (alfa = 0.66. Com os dados desta pesquisa foi feita também análise do Locus de Controle desses mesmos empregados. A constatação mais saliente foi a de que o nível de internalidade caiu com o aumento do nível escolar e o aumento da experiência profissional desses mesmos empregados. Estes resultados surpreendentes foram interpretados em termos da situação típica da empresa, que está passando por um período de transição, a saber: a passagem da condição de empresa estatal para empresa privada, o que seria motivo da perda de confiança dos empregados na própria competência, particularmente por parte daqueles com maior competência intelectual e maior experiência profissional. Fez-se igualmente reparos na qualidade psicométrica da escala e da própria teoria do Locus de controle, no sentido de que esta precisa ser melhor axiomatizada para possibilitar a elaboração de escalas mais precisas para a medida dos construtos que propõe.A scale with 28 items, the Organizational Locus of Control (ELCO, was built based on Rotter’s theory and Levenson’s scale. ELCO was validated on a sample of 350 employees of Telebrás, a governmental firm in Brazil. As foreseen from the theory, a principal-axis factoring showed the presence of the expected two factors, namely internal and external locus of control. The external locus of control factor, composed of 18 items, showed good internal consistency (alpha =.81 whereas the internal factor, with 10 items

  15. Locus of Control Orientation: Parents, Peers, and Place.

    Science.gov (United States)

    Ahlin, Eileen M; Lobo Antunes, Maria João

    2015-09-01

    An internal locus of control contributes to positive youth outcomes such as a general well-being and academic success, while also serving as a protective factor against exposure to community violence and reducing negative behaviors like violence. Despite these benefits, very little is known about antecedents of an internal locus of control orientation. Without an understanding of what factors contribute to the development of an internal locus of control, it is not clear how to best encourage its formation. This study uses data from the Project on Human Development in Chicago Neighborhoods to examine whether various mesosystem variables (family management strategies, peer interactions, neighborhood context, and individual-level characteristics) are associated with an internal locus of control orientation among 1,076 youth ages 9-19 living in 78 Chicago neighborhoods. Study participants were Hispanic (46 %), African American (34 %), and White (15 %), and 50 % were female. The findings suggest that, while most levels of the mesosystem influence locus of control orientation, family management strategies are more prominent determinants of an internal locus of control than peers, neighborhood context, or individual characteristics. Parental supervision over the time a youth spends at home and family socioeconomic status are consistent predictors of an internal locus of control, while harsh discipline is associated with an external locus of control. The discussion examines the import of various parenting techniques in shaping an internal locus of control and considers future avenues for research to further unpack how antecedents of locus of control can vary across youth.

  16. The subsurface geology along the route of the new bridge at Ada Ciganlija Island (Belgrade, Serbia

    Directory of Open Access Journals (Sweden)

    Knežević Slobodan

    2012-01-01

    Full Text Available The largest single-pylon, cable-stayed bridge in the world was opened in Belgrade on January 1, 2012 and it passes over the tip of the Ada Ciganlija Island. Its monumentality, architectural design and construction innovations became a new symbol of Belgrade. Core samples from the boreholes drilled for the construction of the bridge revealed a relatively complex subsurface geological structure. An Upper Cretaceous-Paleogene flysch formation and Middle Miocene Sarmatian sediments were found near the surface on the right bank of the Sava River. However, at the tip of Ada Ciganlija, the Upper Cretaceous-Palaeogene flysch strata were found below several different Miocene and Quaternary units. In the deepest borehole DB-6, the flysch deposits were found at a depth of 80 meters. On the left bank of the Sava River in New Belgrade, only Upper Miocene Pannonian marls and Pleistocene and Holocene alluvial deposits were drilled. Based on a comparative analysis of the borehole sections and structural characteristics of the rocks, it could be concluded that the Pre-Quaternary units cascade subsided along sub-parallel faults towards N-NW. [Projekat Ministarstva nauke Republike Srbije, br. 176015

  17. Subjetividades ameaçadas: mudança de nome de testemunhas protegidas

    Directory of Open Access Journals (Sweden)

    Cássia Maria Rosato

    2013-06-01

    Full Text Available Esse trabalho apresenta um estudo exploratório dos casos de mudança de identidade realizados no Brasil, no âmbito do Programa de Proteção a Vítimas e Testemunhas Ameaçadas, através da Lei Federal 9.807/99. Para tanto, parte dos conceitos de identidade e subjetividade como elementos-chave para identificar e compreender os impactos objetivos e subjetivos dessa medida de proteção. Como não existem estudos brasileiros empíricos sobre mudança de identidade, foram trazidas experiências de programas de proteção de outros países para compará-las à realidade brasileira. Para produzir esses dados foi feita a aplicação de questionários semiestruturados junto a profissionais ligados ao Programa. O objetivo dessa investigação buscou conhecer melhor a mudança de identidade como uma medida de proteção ainda pouco utilizada e consequentemente contribuir para o aperfeiçoamento da política brasileira. Por fim, reconhece-se a importância da Psicologia nos processos de mudança de nome de pessoas ameaçadas.

  18. Computer-aided detection of polyps in CT colonography by means of AdaBoost

    Science.gov (United States)

    Xu, Jian-Wu; Suzuki, Kenji

    2012-03-01

    Computer-aided detection (CADe) has been investigated for assisting radiologists in detecting polyps in CT colonography (CTC). One of the major challenges in current CADe of polyps in CTC is to improve the specificity without sacrificing the sensitivity. We have developed several CADe schemes based on a massive-training framework with different nonlinear regression models such as neural network regression, support vector regression, and Gaussian process regression. Individual CADe schemes based on different nonlinear regression models, however, achieved comparable results. In this paper, we propose to use the AdaBoost algorithm to combine different regression models in CADe schemes for improving the specificity without sacrificing the sensitivity. To test the performance of the proposed approach, we compared it with individual regression models in the distinction between polyps and various types of false positives (FPs). Our CTC database consisted of 246 CTC datasets obtained from 123 patients in the supine and prone positions. The testing set contained 93 patients including 19 polyps in seven patients and 86 negative patients with 474 FPs produced by an original CADe scheme. The AdaBoost algorithm combining multiple massive-training regression models achieved a performance that was higher than each individual regression model, yielding a 94.7% (18/19) bypolyp sensitivity at an FP rate of 2.0 (188/93) per patient in a leave-one-lesion-out cross validation test.

  19. Integrating automated structured analysis and design with Ada programming support environments

    Science.gov (United States)

    Hecht, Alan; Simmons, Andy

    1986-01-01

    Ada Programming Support Environments (APSE) include many powerful tools that address the implementation of Ada code. These tools do not address the entire software development process. Structured analysis is a methodology that addresses the creation of complete and accurate system specifications. Structured design takes a specification and derives a plan to decompose the system subcomponents, and provides heuristics to optimize the software design to minimize errors and maintenance. It can also produce the creation of useable modules. Studies have shown that most software errors result from poor system specifications, and that these errors also become more expensive to fix as the development process continues. Structured analysis and design help to uncover error in the early stages of development. The APSE tools help to insure that the code produced is correct, and aid in finding obscure coding errors. However, they do not have the capability to detect errors in specifications or to detect poor designs. An automated system for structured analysis and design TEAMWORK, which can be integrated with an APSE to support software systems development from specification through implementation is described. These tools completement each other to help developers improve quality and productivity, as well as to reduce development and maintenance costs. Complete system documentation and reusable code also resultss from the use of these tools. Integrating an APSE with automated tools for structured analysis and design provide capabilities and advantages beyond those realized with any of these systems used by themselves.

  20. Faktor-Faktor Dalam Desain Penunjang Buku Autobiografi I Made Ada

    Directory of Open Access Journals (Sweden)

    Asthararianty .

    2009-01-01

    Full Text Available A sculptor named I Made Ada that comes from Pakuduwi village, Tegallalang, Gianyar, Bali and his work of garuda statues have been recognized worlwide. His works are spread all over the world. It causes fear that history will be repeated again. That is a claim from our neighboring country about our origins’ culture. The journey of I Made Ada the sculptor is worth to be documented as an autobiography that contains and tells every authentic data in detail and also so that Indonesian people may know about I Made Ada’s existence. The method used to collect all the needed data are observation, interview, and documentation. The making of an autobiography can create an understanding that this is one of Indonesian richness cultures that need to be kept and preserved. Furthermore, this book is presented as an authentic proof that can facilitate in managing patents and legality rights processes on intellectual properties. This autobiography book is designed by combining modern with traditional impressions and supported by photography, information resources, and other attractive interests.

  1. Beyond the Law: A Review of Knowledge, Attitudes and Perceptions in ADA Employment Research

    Directory of Open Access Journals (Sweden)

    Robert Gould

    2015-09-01

    Full Text Available The Americans with Disabilities Act (ADA, 1990 is the cornerstone of civil rights policy for people with disabilities. Although enforced through the justice system, the legacy of the ADA transcends well beyond its legal ramifications. The policy’s framework and the rhetoric of Disability Rights suggest both an embrace of the spirit and the letter of the law, or promulgating both legislative and cultural change to ensure that the rights of people with disabilities are met.  In attempting to understand how and if such change has happened, researchers have gathered extensive evidence since 1990.  Much of this research evidence, however, remains fragmented, under-utilized, and at times inconclusive.  This article presents the results of a rapid evidence review of a sample of such research that is crucial to understand the ADA’s progress.  The study examines evidence about the ADA’s influence on knowledge, attitudes and perceptions about employment of people with disabilities. The research illustrates the importance of moving beyond the law to incorporate changes in knowledge about the law, perceptions of employability, and workplace culture.

  2. Mason Tenders agrees to pay $1 million to end ADA litigation.

    Science.gov (United States)

    1995-12-29

    The [name removed] District Council Welfare Fund has agreed to pay $1 million to construction workers who have been denied medical coverage for AIDS-related care. The decision establishes self-insured health care benefits programs as covered entities under the Americans with Disabilities Act (ADA). The settlement ends a three-year battle which began in 1992 between [name removed] and fourteen HIV-positive construction workers who were refused medical coverage. The first suit was filed by [name removed]., a construction worker who lost coverage for his HIV-related care in July 1991. At that time, the union fund decided to exclude care for HIV on the grounds that it was too expensive. The Equal Employment Opportunity Commission (EEOC) filed an ADA lawsuit that challenged disability-based distinctions in health insurance. The U.S. Attorney's Office filed a complaint against the union under the Racketeer Influenced and Corrupt Organizations (RICO) statute to end organized crime associated with the union. In late 1994, the government announced a consent decree, settling its racketeering suit against the union. Under the terms of the settlement, [name removed] was awarded $16,000 in damages. In the EEOC case, damages for plan members ranged as high as $50,000.

  3. OFICINA DE ORIGAMI: ATIVIDADE DESENVOLVIDA NO ENSINO FUNDAMENTAL A PARTIR DO TEMA OLIMPÍADAS

    Directory of Open Access Journals (Sweden)

    Joyce dos Santos Vieira

    2017-05-01

    Full Text Available Utilizar diferentes metodologias e ferramentas em sala de aula exige do professor conhecimento e interesse por propiciarem um estímulo no processo de ensino-aprendizagem dos alunos. Neste trabalho foi desenvolvida uma oficina de origami para uma turma do 6º Ano do Ensino Fundamental da E.E.E.F.M. ”Professor Pedro Simão” no município de Alegre-ES. O objetivo da mesma foi confeccionar/representar alguns animais e plantas da fauna e flora brasileira para compor uma maquete para o projeto da escola com o tema das olimpíadas. A oficina foi realizada em três aulas com a confecção dos modelos de uma borboleta, um macaco e da flor vinca Catharanthus roseus, abordando a sustentabilidade e a preservação ambiental, ambos os temas relacionados às olimpíadas. A participação e o empenho dos alunos foram surpreendentes, evidenciando que atividades diferenciadas podem aproximar o aluno de qualquer tema que o professor queira abordar, quando trabalhado de forma contextualizada, propiciando uma interação entre alunos e professores.

  4. Plantio direto de alface americana sobre plantas de cobertura dessecadas ou roçadas

    Directory of Open Access Journals (Sweden)

    Andréia Cristina Silva Hirata

    2014-06-01

    Full Text Available O objetivo deste trabalho foi avaliar o plantio direto de alface americana no verão sobre plantas de cobertura dessecadas ou roçadas em cultivos sucessivos. O trabalho foi desenvolvido no município de Álvares Machado, São Paulo, Brasil. O delineamento experimental foi em blocos ao acaso, dispostos em parcelas subdivididas, com quatro repetições. O fator da parcela principal foram dois manejos das plantas de cobertura (dessecadas com herbicida ou roçadas e as subparcelas, seis espécies de plantas de cobertura (Cajanus cajan cv. IAPAR 43, Crotalaria spectabilis, Crotalaria juncea, Mucuna pruriens, Pennisetum glaucum e vegetação natural, além da testemunha sem plantas de cobertura. O manejo roçado apresentou desempenho inferior no primeiro cultivo da alface, todavia não diferiu do manejo químico no segundo cultivo. A cobertura do solo com mucuna apresentou maior produtividade da alface no primeiro cultivo devido ao excesso de palha das demais coberturas, o qual prejudicou o estabelecimento da alface. No segundo cultivo não houve diferenças entre as coberturas. A roçagem de plantas de cobertura é uma opção viável para plantio direto de alface sem herbicidas.

  5. Health Locus of Control尺度開発の歴史(社会科学編)

    OpenAIRE

    吉田, 由美; Yumi, Yoshida; 千葉県立衛生短期大学(歯科保存学); Chiba College of Health Science

    1994-01-01

    This article describes the origins history of Health Locus of Control scales. First, Rotter's social learing theory, which is the theoretical background of the Health Locus of Control construct, is outlined. The scale and research trends of Locus of Control concept, and those of Health Locus of Control concept which are based on Locus of Control, are then reviewed. Finally, Health Locus of Control is discussed with regard to the implications for health education.

  6. Longer-term effects of ADAS use on speed and headway control in drivers diagnosed with Parkinson's disease.

    Science.gov (United States)

    Dotzauer, Mandy; Caljouw, Simone R; De Waard, Dick; Brouwer, Wiebo H

    2015-01-01

    An advanced driver assistance system (ADAS) provided information about speed limits, speed, speeding, and following distance. Information was presented to the participants by means of a head-up display. Effects of the information on speed and headway control were studied in a longer-term driving simulator study including 12 repeated measures spread out over 4 weeks. Nine healthy older drivers between the ages of 65 and 82 years and 9 drivers between the ages of 68 and 82 years diagnosed with Parkinson's disease (PD) participated in the study. Within the 4 weeks, groups completed 12 consecutive sessions (10 with ADAS and 2 without ADAS) in a driving simulator. Results indicate an effect of ADAS use on performance. Removing ADAS after short-term exposure led to deterioration of performance in all speed measures in the group of drivers diagnosed with PD. These results suggest that provision of traffic information was utilized by drivers diagnosed with PD in order to control their speed.

  7. Ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) and adenosine deaminase (ADA) activities in prostate cancer patients: influence of Gleason score, treatment and bone metastasis.

    Science.gov (United States)

    Battisti, Vanessa; Maders, Liési D K; Bagatini, Margarete D; Battisti, Iara E; Bellé, Luziane P; Santos, Karen F; Maldonado, Paula A; Thomé, Gustavo R; Schetinger, Maria R C; Morsch, Vera M

    2013-04-01

    The relation between adenine nucleotides and cancer has already been described in literature. Considering that the enzymes ectonucleotide pyrophosphatase/phosphodiesterase (E-NPP) and adenosine deaminase (ADA) act together to control nucleotide levels, we aimed to investigate the role of these enzymes in prostate cancer (PCa). E-NPP and ADA activities were determined in serum and platelets of PCa patients and controls. We also verified the influence of the Gleason score, bone metastasis and treatment in the enzyme activities. Platelets and serum E-NPP activity increased, whereas ADA activity in serum decreased in PCa patients. In addition, Gleason score, metastasis and treatment influenced E-NPP and ADA activities. We may propose that E-NPP and ADA are involved in the development of PCa. Moreover, E-NPP and ADA activities are modified in PCa patients with distinct Gleason score, with bone metastasis, as well as in patients under treatment. Copyright © 2013 Elsevier Masson SAS. All rights reserved.

  8. Ada (Tradename) Compiler Validation Summary Report. CAP Industry Ltd. CAPTACS-E286, V1.0. Host: DEC VAX 8800. Target: INTEL 80286.

    Science.gov (United States)

    1986-12-11

    34 To determine that the iplementation-dependent behaviour is allowed by the Ada Standard Testing of this compiler was conducted by NOC under the...this report are accurate and complete, or that the subject compiler has no nonconformities to the Ada Standard other than those presented. Copies of...cross-ocipilers, translators, and interpreters. Failed test A test for which the ompiler generates a result that demonstrates nonconformity to the Ada

  9. ADA (Trade Name) Software Engineering Education and Training Symposium (2nd) Held in Dallas, Texas on 9-11 June 1987.

    Science.gov (United States)

    1987-06-11

    started implementing the programming language Ada as the departamental language. After almost 3 years into the project, we feel we have succeeded. The...of the following topics University Setting. Departamental Setting Curriculum overview. Ada as a Primary Programming Language. Ada curriculum... departamental language I proceed to state our common teaching philosophy and goals. at least with respect to the programming courses. In our teaching

  10. Detecting purely epistatic multi-locus interactions by an omnibus permutation test on ensembles of two-locus analyses

    Directory of Open Access Journals (Sweden)

    Limwongse Chanin

    2009-09-01

    Full Text Available Abstract Background Purely epistatic multi-locus interactions cannot generally be detected via single-locus analysis in case-control studies of complex diseases. Recently, many two-locus and multi-locus analysis techniques have been shown to be promising for the epistasis detection. However, exhaustive multi-locus analysis requires prohibitively large computational efforts when problems involve large-scale or genome-wide data. Furthermore, there is no explicit proof that a combination of multiple two-locus analyses can lead to the correct identification of multi-locus interactions. Results The proposed 2LOmb algorithm performs an omnibus permutation test on ensembles of two-locus analyses. The algorithm consists of four main steps: two-locus analysis, a permutation test, global p-value determination and a progressive search for the best ensemble. 2LOmb is benchmarked against an exhaustive two-locus analysis technique, a set association approach, a correlation-based feature selection (CFS technique and a tuned ReliefF (TuRF technique. The simulation results indicate that 2LOmb produces a low false-positive error. Moreover, 2LOmb has the best performance in terms of an ability to identify all causative single nucleotide polymorphisms (SNPs and a low number of output SNPs in purely epistatic two-, three- and four-locus interaction problems. The interaction models constructed from the 2LOmb outputs via a multifactor dimensionality reduction (MDR method are also included for the confirmation of epistasis detection. 2LOmb is subsequently applied to a type 2 diabetes mellitus (T2D data set, which is obtained as a part of the UK genome-wide genetic epidemiology study by the Wellcome Trust Case Control Consortium (WTCCC. After primarily screening for SNPs that locate within or near 372 candidate genes and exhibit no marginal single-locus effects, the T2D data set is reduced to 7,065 SNPs from 370 genes. The 2LOmb search in the reduced T2D data reveals

  11. Using Penelope to assess the correctness of NASA Ada software: A demonstration of formal methods as a counterpart to testing

    Science.gov (United States)

    Eichenlaub, Carl T.; Harper, C. Douglas; Hird, Geoffrey

    1993-01-01

    Life-critical applications warrant a higher level of software reliability than has yet been achieved. Since it is not certain that traditional methods alone can provide the required ultra reliability, new methods should be examined as supplements or replacements. This paper describes a mathematical counterpart to the traditional process of empirical testing. ORA's Penelope verification system is demonstrated as a tool for evaluating the correctness of Ada software. Grady Booch's Ada calendar utility package, obtained through NASA, was specified in the Larch/Ada language. Formal verification in the Penelope environment established that many of the package's subprograms met their specifications. In other subprograms, failed attempts at verification revealed several errors that had escaped detection by testing.

  12. Reinforcement of genetic coherence in a two-locus model.

    Science.gov (United States)

    Gregorius, H R; Steiner, W

    2001-01-01

    In order to maintain populations as units of reproduction and thus enable anagenetic evolution, genetic factors must exist which prevent continuing reproductive separation or enhance reproductive contact. This evolutionary principle is called genetic coherence and it marks the often ignored counterpart of cladistic evolution. Possibilities of the evolution of genetic coherence are studied with the help of a two-locus model with two alleles at each locus. The locus at which viability selection takes place is also the one that controls the fusion of gametes. The second locus acts on the first by modifying the control of the fusion probabilities. It thus acts as a mating modifier whereas the first locus plays the role of the object of selection and mating. Genetic coherence is enhanced by modifications which confer higher probabilities of fusion to heterotypic gametic combinations (resulting in heterozygous zygotes) at the object locus. It is shown that mutants at the mating modifier locus, which increase heterotypic fusions but do not lower the homotpyic fusions relative to the resident allele at the object locus, generally replace the resident allele. Since heterozygote advantage at the object locus is a necessary condition for this result to hold true, reinforcement of genetic coherence can be claimed for this case. If the homotypic fusions are lowered, complex situations may arise which may favor or disfavor the mutant depending on initial frequencies and recombination rates. To allow for a generalized analysis including alternative models of genetic coherence as well as the estimation of its degrees in real populations, an operational concept for the measurement of this degree is developed. The resulting index is applied to the interpretation of data from crossing experiments in Alnus species designed to detect incompatibility relations.

  13. Reinforcement of genetic coherence in a two-locus model

    Directory of Open Access Journals (Sweden)

    Steiner Wilfried

    2001-08-01

    Full Text Available Abstract Background In order to maintain populations as units of reproduction and thus enable anagenetic evolution, genetic factors must exist which prevent continuing reproductive separation or enhance reproductive contact. This evolutionary principle is called genetic coherence and it marks the often ignored counterpart of cladistic evolution. Possibilities of the evolution of genetic coherence are studied with the help of a two-locus model with two alleles at each locus. The locus at which viability selection takes place is also the one that controls the fusion of gametes. The second locus acts on the first by modifying the control of the fusion probabilities. It thus acts as a mating modifier whereas the first locus plays the role of the object of selection and mating. Genetic coherence is enhanced by modifications which confer higher probabilities of fusion to heterotypic gametic combinations (resulting in heterozygous zygotes at the object locus. Results It is shown that mutants at the mating modifier locus, which increase heterotypic fusions but do not lower the homotpyic fusions relative to the resident allele at the object locus, generally replace the resident allele. Since heterozygote advantage at the object locus is a necessary condition for this result to hold true, reinforcement of genetic coherence can be claimed for this case. If the homotypic fusions are lowered, complex situations may arise which may favor or disfavor the mutant depending on initial frequencies and recombination rates. To allow for a generalized analysis including alternative models of genetic coherence as well as the estimation of its degrees in real populations, an operational concept for the measurement of this degree is developed. The resulting index is applied to the interpretation of data from crossing experiments in Alnus species designed to detect incompatibility relations.

  14. EL LOCUS DE DISTRIBUCION COMO COROLARIO DEL LOCUS DE CONTROL (THE LOCUS OF DISTRIBUTION AS A COROLLARY TO THE LOCUS OF CONTROL

    Directory of Open Access Journals (Sweden)

    Mayoral Luisa

    2009-08-01

    Full Text Available Resumen: Este es un artículo científico acerca del Locus de Distribución, surgido de un estudio realizado con una población de docentes y alumnos universitarios. Respecto de los primeros, se ha indagado acerca de las atribuciones que se realizaban en torno a las recompensas y sanciones, que ellos distribuían a sus alumnos.Respecto de los segundos, se ha buscado determinar la valoración que estos realizaban de sus profesores, en términos de aquellas atribuciones. Para ello, se utilizaron dos paradigmas clásicamente empleados para verificar la existencia de una norma: el paradigma de la autopresentación (docentes, y el paradigma de los j uicios (alumnos. La cuestión planteada fue determinar si en el caso de los comportamientos distributivos de refuerzos, las causas se atribuían a variables externas -en particular a los receptores de esos refuerzos- y si esas formas de atribución eran conocidas y valoradas o no, por los alumnos. De los resultados, surgió la confirmación de nuestra hipótesis de explicaciones externas en materia de comportamientos distributivos de sanciones en el ámbito de la docencia y la valoración positiva de estas atribuciones por los alumnos.Abstract:This one is a scientific article brings over of the Locus of Distribution, arisen from a study realized with a population of teachers and university pupils. Respect of the first ones, it has been investigated brings over of the attributions that were concerning around the reinforcements which they were distributing to pupils. Respect of the second ones, one has sought to determine the valuation that these realized of the teachers, in terms of those attributions. For it, two paradigms were in use classic used to check the existence of a norm: the paradigm of the auto-presentation (teachers, and the paradigm of the judgments (pupils The raised question was to determine if in case of the distributive behaviours of reinforcements, the reasons were assuming to external

  15. Evolutionary process of a tetranucleotide microsatellite locus in ...

    Indian Academy of Sciences (India)

    ... France; Institut des Sciences de l'Evolution (UMR UM2-CNRS 5554) University Montpellier II, cc 065. Place E. Bataillon 34095 Montpellier Cedex 5, France; Methods and Algorithms for Bioinformatics, L.I.R.M.M., UMR 5506 CNRS - Université de Montpellier II, CC 477, 161 rue Ada, F-34095 Montpellier Cedex 5, France ...

  16. Generators of synchronous activity of the locus coeruleus during development.

    Science.gov (United States)

    Christie, M J

    1997-02-01

    The locus coeruleus is thought to play an important role in the development of the central nervous system through a coordinated release of noradrenaline. The influence of the locus coeruleus on its diverse targets is strongly synchronized by the existence of electrical and chemical coupling between neurones, afferent supply of the nucleus from restricted sources and diffuse innervation of target areas. Extensive coupling between neonatal locus coeruleus neurones produces rhythmic synchronized electrical activity and distributes afferent synaptic activity throughout the entire nucleus. The strength of electrical coupling declines with age but appears to persist to a limited extent in the adult.

  17. Relation of organizational citizenship behavior and locus of control.

    Science.gov (United States)

    Turnipseed, David L; Bacon, Calvin M

    2009-12-01

    The relation of organizational citizenship behavior and locus of control was assessed in a sample of 286 college students (52% men; M age = 24 yr.) who worked an average of 26 hr. per week. Measures were Spector's Work Locus of Control Scale and Podsakoff, et al.'s Organization Citizenship Behavior scale. Hierarchical multiple regressions indicated positive association of scores on work locus of control with scores on each of the four tested dimensions of organizational citizenship, as well as total organizational citizenship behavior.

  18. SMARTPHONE-BASED APPROACH TO ADVANCED DRIVER ASSISTANCE SYSTEM (ADAS RESEARCH AND DEVELOPMENT

    Directory of Open Access Journals (Sweden)

    I. B. Lashkov

    2015-11-01

    Full Text Available Subject of Research.The paper deals with findings and presents asmartphone-based approach to advanced driver assistance system (ADAS research and development.The approach is based on the data of smartphone cameras and sensors. The line of researchis associated with the developmentof mobile advanced driver assistance system (ADAS. Method.The proposedapproach isbased on the use of driver'sand vehicle behavior ontologies. Current ADAS systems can be divided into two main categories according to the method of implementation: mobile applications, manually installed by the driver from the application stores, and safetyhardware and softwaresystems,integrated into vehicles by manufacturesor in the automotive service centers.Mobile application installed on the smartphone uses the built-in rear and front-facing cameras and sensors to monitor both the road and vehicles ahead, and at the same time the driver in order to prevent traffic collisions. The service consists of components for objects recognition in the images obtained with cameras, and components for traffic situation analysis. Main Results. The driver safety mobile application has been developedfor the use on mobile phones.The mobile phone is mounted on the windshield of a car.In case of dangerous event occurrence, the application engine will make an audible or vibration signal to inform the driver to be concentratedand more vigilant. For example, road obstacles, rear-end and stationary vehicle accidents are the most common accident types.The mobile application detects whether a crash is imminent by computing the ‘Time To Contact’ (TTC taking into account host vehicle speed, relative speed and relative acceleration.If the driver doesn’t maintain safe minimum distance with the car immediately ahead, the mobile application will alert the driver by displaying an attention icon with an audible alert. The dual-camera sensing application is designed to help the drivers increase the trip safety

  19. A Distal Locus Element Mediates IFN-γ Priming of Lipopolysaccharide-Stimulated TNF Gene Expression

    Directory of Open Access Journals (Sweden)

    Nancy A. Chow

    2014-12-01

    Full Text Available Interferon γ (IFN-γ priming sensitizes monocytes and macrophages to lipopolysaccharide (LPS stimulation, resulting in augmented expression of a set of genes including TNF. Here, we demonstrate that IFN-γ priming of LPS-stimulated TNF transcription requires a distal TNF/LT locus element 8 kb upstream of the TNF transcription start site (hHS-8. IFN-γ stimulation leads to increased DNase I accessibility of hHS-8 and its recruitment of interferon regulatory factor 1 (IRF1, and subsequent LPS stimulation enhances H3K27 acetylation and induces enhancer RNA synthesis at hHS-8. Ablation of IRF1 or targeting the hHS-8 IRF1 binding site in vivo with Cas9 linked to the KRAB repressive domain abolishes IFN-γ priming, but does not affect LPS induction of the gene. Thus, IFN-γ poises a distal enhancer in the TNF/LT locus by chromatin remodeling and IRF1 recruitment, which then drives enhanced TNF gene expression in response to a secondary toll-like receptor (TLR stimulus.

  20. An autoregulatory pathway establishes the definitive chromatin conformation at the pit-1 locus.

    Science.gov (United States)

    Ho, Yugong; Cooke, Nancy E; Liebhaber, Stephen A

    2015-05-01

    The transcription factor Pit-1 (POU1-F1) plays a dominant role in cell lineage expansion and differentiation in the anterior pituitary. Prior studies of the mouse Pit-1 (mPit-1) gene revealed that this master regulatory locus is activated at embryonic day 13.5 (E13.5) by an early enhancer (EE), whereas its subsequent expression throughout adult life is maintained by a more distal definitive enhancer (DE). Here, we demonstrate that the sequential actions of these two enhancers are linked to corresponding shifts in their proximities to the Pit-1 promoter. We further demonstrate that the looping of the definitive enhancer to the mPit-1 promoter is critically dependent on a self-sustaining autoregulatory mechanism mediated by the Pit-1 protein. These Pit-1-dependent actions are accompanied by localized recruitment of CBP and enrichment for H3K27 acetylation within the Pit-1 locus. These data support a model in which the sequential actions of two developmentally activated enhancers are linked to a corresponding shift in higher-order chromatin structures. This shift establishes an autoregulatory circuit that maintains durable expression of Pit-1 throughout adult life. Copyright © 2015, American Society for Microbiology. All Rights Reserved.

  1. Multiclass AdaBoost ELM and Its Application in LBP Based Face Recognition

    Directory of Open Access Journals (Sweden)

    Yunliang Jiang

    2015-01-01

    Full Text Available Extreme learning machine (ELM is a competitive machine learning technique, which is simple in theory and fast in implementation; it can identify faults quickly and precisely as compared with traditional identification techniques such as support vector machines (SVM. As verified by the simulation results, ELM tends to have better scalability and can achieve much better generalization performance and much faster learning speed compared with traditional SVM. In this paper, we introduce a multiclass AdaBoost based ELM ensemble method. In our approach, the ELM algorithm is selected as the basic ensemble predictor due to its rapid speed and good performance. Compared with the existing boosting ELM algorithm, our algorithm can be directly used in multiclass classification problem. We also carried out comparable experiments with face recognition datasets. The experimental results show that the proposed algorithm can not only make the predicting result more stable, but also achieve better generalization performance.

  2. Discordant Haplotype Sequencing Identifies Functional Variants at the 2q33 Breast Cancer Risk Locus.

    Science.gov (United States)

    Camp, Nicola J; Lin, Wei-Yu; Bigelow, Alex; Burghel, George J; Mosbruger, Timothy L; Parry, Marina A; Waller, Rosalie G; Rigas, Sushilaben H; Tai, Pei-Yi; Berrett, Kristofer; Rajamanickam, Venkatesh; Cosby, Rachel; Brock, Ian W; Jones, Brandt; Connley, Dan; Sargent, Robert; Wang, Guoying; Factor, Rachel E; Bernard, Philip S; Cannon-Albright, Lisa; Knight, Stacey; Abo, Ryan; Werner, Theresa L; Reed, Malcolm W R; Gertz, Jason; Cox, Angela

    2016-04-01

    The findings from genome-wide association studies hold enormous potential for novel insight into disease mechanisms. A major challenge in the field is to map these low-risk association signals to their underlying functional sequence variants (FSV). Simple sequence study designs are insufficient, as the vast numbers of statistically comparable variants and a limited knowledge of noncoding regulatory elements complicate prioritization. Furthermore, large sample sizes are typically required for adequate power to identify the initial association signals. One important question is whether similar sample sizes need to be sequenced to identify the FSVs. Here, we present a proof-of-principle example of an extreme discordant design to map FSVs within the 2q33 low-risk breast cancer locus. Our approach employed DNA sequencing of a small number of discordant haplotypes to efficiently identify candidate FSVs. Our results were consistent with those from a 2,000-fold larger, traditional imputation-based fine-mapping study. To prioritize further, we used expression-quantitative trait locus analysis of RNA sequencing from breast tissues, gene regulation annotations from the ENCODE consortium, and functional assays for differential enhancer activities. Notably, we implicate three regulatory variants at 2q33 that target CASP8 (rs3769823, rs3769821 in CASP8, and rs10197246 in ALS2CR12) as functionally relevant. We conclude that nested discordant haplotype sequencing is a promising approach to aid mapping of low-risk association loci. The ability to include more efficient sequencing designs into mapping efforts presents an opportunity for the field to capitalize on the potential of association loci and accelerate translation of association signals to their underlying FSVs. Cancer Res; 76(7); 1916-25. ©2016 AACR. ©2016 American Association for Cancer Research.

  3. Soil microorganisms numbers in the tailing deposition ModADA areas of Freeport Indonesia, Timika, Papua

    Directory of Open Access Journals (Sweden)

    IRNANDA AIKO FIFI DJUUNA

    2011-10-01

    Full Text Available Djuuna IAF, Masora M, Puradyatmika P (2011 Soil microorganisms numbers in the tailing deposition ModADA areas of Freeport Indonesia, Timika, Papua. Biodiversitas 12: 198-203. The objective of this study was to examine the number and distribution of bacteria, fungi and actinomycetes in the inactive tailing deposition areas of Freeport Indonesia Mining and Gold Company, Timika. One hundred ninety eight composite samples (0-20 cm were taken from four location of inactive tailing ModADA (Modification Aijkwa Deposition Areas namely double levee-bottom (fine texture; double levee-middle (medium texture; double levee-top (coarse texture; Mile 21 and transmigration areas of I to V. The conventional method of dilution and Plate Count Agar were used to examine the population of soil bacteria, fungi and actinomycetes. pH and moisture content were also analyzed. The numbers of bacteria in the tailing deposition areas are in the range from 3.48x105 CFU/g soil to 102.83x105 CFU/g soil, soil fungi from 1.51x105 CFU/g soil to 106.61x105 CFU/g soil and actinomycetes range from 0.32x104 CFU/g soil to 113.74x104 CFU/g soil. While in some transmigration areas, the number of soil bacteria, fungi and actinomycetes were lower than in the tailing areas. The number of soil bacteria and fungi were higher than actinomycetes. However, the coefficient of variation of actinomycetes (107% was higher than soil fungi (89% and bacteria (68%. Tailing deposition areas are considered as a good habitat for soil microorganisms. Overall, the number of soil organism in the tailings areas are considered medium to high, however to understand their functioning in each location under different land use system, more research are needed to evaluate their roles especially in the decomposition of soil organic matter.

  4. Distribution of Isotopic and Environmental Tracers in Groundwater, Northern Ada County, Southwestern Idaho

    Science.gov (United States)

    Adkins, Candice B.; Bartolino, James R.

    2010-01-01

    Residents of northern Ada County, Idaho, depend on groundwater for domestic and agricultural uses. The population of this area is growing rapidly and groundwater resources must be understood for future water-resource management. The U.S. Geological Survey, in cooperation with the Idaho Department of Water Resources, used a suite of isotopic and environmental tracers to gain a better understanding of groundwater ages, recharge sources, and flowpaths in northern Ada County. Thirteen wells were sampled between September and October 2009 for field parameters, major anions and cations, nutrients, oxygen and hydrogen isotopes, tritium, radiocarbon, chlorofluorocarbons, and dissolved gasses. Well depths ranged from 30 to 580 feet below land surface. Wells were grouped together based on their depth and geographic location into the following four categories: shallow aquifer, intermediate/deep aquifer, Willow Creek aquifer, and Dry Creek aquifer. Major cations and anions indicated calcium-bicarbonate and sodium-bicarbonate water types in the study area. Oxygen and hydrogen isotopes carried an oxygen-18 excess signature, possibly indicating recharge from evaporated sources or water-rock interactions in the subsurface. Chlorofluorocarbons detected modern (post-1940s) recharge in every well sampled; tritium data indicated modern water (post-1951) in seven, predominantly shallow wells. Nutrient concentrations tended to be greater in wells signaling recent recharge based on groundwater age dating, thus confirming the presence of recent recharge in these wells. Corrected radiocarbon results generated estimated residence times from modern to 5,100 years before present. Residence time tended to increase with depth, as confirmed by all three age-tracers. The disagreement among residence times indicates that samples were well-mixed and that the sampled aquifers contain a mixture of young and old recharge. Due to a lack of data, no conclusions about sources of recharge could be drawn

  5. The Comparison Flow of Four Impression Compounds (Green Stick with ADA Standard

    Directory of Open Access Journals (Sweden)

    S. Mir Mohammad Rezaei

    2004-09-01

    Full Text Available Statement of Problem: Low- fusing compound (type 1 is used for border molding and impressions. Flow and reproducibility of surface detail are two important characteristics of these materials. There are no valid data available comparing domestic and imported brands.Purpose: The Purpose of this study was to evaluate these two properties of four different products including Kerr (Kerr Manufacture MI 98174-2600, Harvard (Hoffman Harvard Dental GMb H Germany; Kymia (Kymia dental company 713 Iran; and Pishro (Pishro72534 Iran.Materials and Methods: All procedures were followed according to ADA and BSStandard.Total number of 48 samples were divided into 8 groups (6 in each group.Twenty disks were fabricated for impression tests. The specimen dimensions were 40 mm (diameter and 6mm (thickness. Standard test blocks were used to test the specimens.Results: The Willcoxon test showed significant difference in flow rate between materials tested with the best result for Kerr (P<0.05. Kerr flow was 85% and under 5% at 45°C and 37°C, respectively. There were great deviations from standards value at 45°C. For the rest of the samples at 37°C; except Kymia the flow rate for 3 materials (Kerr; Harvard Pishrowere almost acceptable. The impression test results revealed that only Kerr was able torecord the details at 45°C.Conclusion: Kerr flow is exactly what ADA standards specify. But the flow rate for three materials exhibit a great distance from these standards. In impression test only Kerr was able to record the details

  6. Relationship among Dimensions of Family Communication Patterns and Locus of

    Directory of Open Access Journals (Sweden)

    Mohammad Hassan Anvari

    2014-05-01

    Full Text Available Background: This study was done to examine the relationship of self-efficacy with dimensions of family communication patterns and locus of control. Materials and Methods: The population of this study was all Isfahan University students in the 2010-2011 academic years. Two hundred seventy nine students from various faculties of the university selected by cluster sampling method. In this descriptive study were used from the revised scale of dimensions of family communication patterns, locus of control questionnaire and general self-efficacy scale. Results: Results showed that the dialogue orientation, locus of control and conformity orientation have a significant correlation with self-efficacy (p<0.01. In addition dialogue orientation, locus of control and conformity orientation predicted 13%, 7%, 2% of selfefficacy, respectively. Conclusion: Dialogue orientation in family is the most important predictor of students' self-efficacy.

  7. Multidimensional profiles of health locus of control in Hispanic Americans.

    Science.gov (United States)

    Champagne, Brian R; Fox, Rina S; Mills, Sarah D; Sadler, Georgia Robins; Malcarne, Vanessa L

    2016-10-01

    Latent profile analysis identified health locus of control profiles among 436 Hispanic Americans who completed the Multidimensional Health Locus of Control scales. Results revealed four profiles: Internally Oriented-Weak, -Moderate, -Strong, and Externally Oriented. The profile groups were compared on sociocultural and demographic characteristics, health beliefs and behaviors, and physical and mental health outcomes. The Internally Oriented-Strong group had less cancer fatalism, religiosity, and equity health attributions, and more alcohol consumption than the other three groups; the Externally Oriented group had stronger equity health attributions and less alcohol consumption. Deriving multidimensional health locus of control profiles through latent profile analysis allows examination of the relationships of health locus of control subtypes to health variables. © The Author(s) 2015.

  8. A new strategy for estimating two-locus recombination fractions ...

    Indian Academy of Sciences (India)

    2011-08-19

    locus recombination fractions under some natural inequality restrictions. J. Genet. 90, 275–282]. Introduction. Linkage analysis is used in both human and other biologi- cal studies. Lathrop et al. (1984) discussed the strategies ...

  9. Locus of Control and Technology Adoption in Developing Country Agriculture

    DEFF Research Database (Denmark)

    Abay, Kibrom Araya; Blalock, Garrick; Berhane, Guush

    2017-01-01

    adoption decisions, including use of chemical fertilizers, improved seeds, and irrigation. We show that individuals with an internal locus of control have higher propensity of adopting agricultural technologies. We observe these empirical regularities in both datasets, and for both revealed measures......We investigate the implication of farmers’ locus of control on their technology adoption decisions. Our empirical analysis is based on two longitudinal surveys and hypothetical choice exercises conducted on Ethiopian farmers. We find that locus of control significantly predicts farmers’ technology...... of farmers’ technology adoption decisions as well as farmers’ hypothetical demand for agricultural technology. The results hold even in a more conservative fixed effects estimation approach, assuming locus of control as time-variant and dynamic behavioral trait. These findings provide behavioral...

  10. A canine chromosome 7 locus confers compulsive disorder susceptibility

    National Research Council Canada - National Science Library

    Dodman, N H; Karlsson, E K; Moon-Fanelli, A; Galdzicka, M; Perloski, M; Shuster, L; Lindblad-Toh, K; Ginns, E I

    2010-01-01

    ... pincher CCD with a chromosome 7 locus containing , an attractive candidate.Genome-wide association analyses were performed using DNA from 92 rigorously phenotyped Doberman pinscher FS BS cases and 6...

  11. NRC regulatory initiatives

    Energy Technology Data Exchange (ETDEWEB)

    Johnson, T.C. [Nuclear Regulatory Commission (United States)

    1989-11-01

    The US Nuclear Regulatory Commission (NRC) is addressing several low-level waste disposal issues that will be important to waste generators and to States and Compacts developing new disposal capacity. These issues include Greater-Than-Class C (GTCC) waste, mixed waste, below regulatory concern (BRC) waste, and the low-level waste data base. This paper discusses these issues and their current status.

  12. Regulatory unbundling in telecommunications

    OpenAIRE

    Knieps, Günter

    2011-01-01

    Due to its dynamic nature, and the increasing importance of competitive sub-parts, the telecommunications sector provides particularly interesting insights for studying regulatory unbundling. Based on the theory of monopolistic bottle-necks the fallacies of overregulation by undue unbundling obligations are indicated. Neither the promotion of infrastructure competition by mandatory un-bundling of competitive subparts of telecommunications infrastructure, nor regulatory induced network fragmen...

  13. Ada Compiler Validation Summary Report: Certificate Number 901214N1. 11080 SD-Scicon UK Limited XD Ada MIL-STD-1750A Version 1.2 Local Area VAX cluster Host and MIL-STD-1750A Target

    Science.gov (United States)

    1990-08-15

    of making the modifications described in the preceding paragraph, removing withdrawn tests ( sec scrion 2.1) and, possibly some inapplicable tests (see...no annotation. SYMBOLIC:NORMAL Provides machine code in the listing file; where poble , instructions are annotated with simple Ada names

  14. Canadian drug regulatory framework.

    Science.gov (United States)

    Kelly, L; Lazzaro, M; Petersen, C

    2007-03-01

    The role of regulatory drug submission evaluators in Canada is to critically assess both the data submitted and the sponsor's interpretation of the data in order to reach an evidence-, and context-based recommendation as to the potential benefits and potential harms (i.e., risks) associated with taking the drug under the proposed conditions of use. The purpose of this document is to outline the regulatory framework in which this assessment occurs, including: defining what "authorization to market a drug in Canada" means, in terms of the role of the sponsor, the responsibility of Health Canada in applying the Food and Drugs Act prior to and after marketing authorization, and the distinction between regulatory authorization versus physician authorization; highlighting organizational, process and legal factors within Health Canada related to authorization of clinical trials and authorization to market a drug; considerations during the review process, such as regulatory and scientific issues related to the drug, patient populations and trial designs; application of international guidelines, and decisions from other jurisdictions; regulatory realities regarding drug authorization, including the requirement for wording in the Product Monograph to accurately reflect the information currently available on the safe and effective use of a drug, and that hypothesis-confirming studies are essential to regulatory endorsement; current issues related to the review of therapies for dementia, such as assessing preventative treatments, and therapies that have symptomatic versus disease-modifying effects, statistical issues regarding missing data, and trial design issues.

  15. Neurolinguistic programming training, trait anxiety, and locus of control.

    Science.gov (United States)

    Konefal, J; Duncan, R C; Reese, M A

    1992-06-01

    Training in the neurolinguistic programming techniques of shifting perceptual position, visual-kinesthetic dissociation, timelines, and change-history, all based on experiential cognitive processing of remembered events, leads to an increased awareness of behavioral contingencies and a more sensitive recognition of environmental cues which could serve to lower trait anxiety and increase the sense of internal control. This study reports on within-person and between-group changes in trait anxiety and locus of control as measured on the Spielberger State-Trait Anxiety Inventory and Wallston, Wallston, and DeVallis' Multiple Health Locus of Control immediately following a 21-day residential training in neurolinguistic programming. Significant with-in-person decreases in trait-anxiety scores and increases in internal locus of control scores were observed as predicted. Chance and powerful other locus of control scores were unchanged. Significant differences were noted on trait anxiety and locus of control scores between European and U.S. participants, although change scores were similar for the two groups. These findings are consistent with the hypothesis that this training may lower trait-anxiety scores and increase internal locus of control scores. A matched control group was not available, and follow-up was unfortunately not possible.

  16. [Health locus of control of patients in disease management programmes].

    Science.gov (United States)

    Schnee, M; Grikscheit, F

    2013-06-01

    Health locus of control beliefs plays a major role in improving self-management skills of the chronically ill - a main goal in disease management programmes (DMP). This study aims at characterising participants in disease management regarding their health locus of control. Data are based on 4 cross-sectional postal surveys between spring and autumn of 2006 and 2007 within the Health Care Monitor of the Bertelsmann Foundation. Among the 6 285 respondents, 1 266 are chronically ill and not enrolled in a DMP and 327 are participating in a DMP. A high internal locus of control (HLC) occurs significantly less often in DMP patients than in normal chronically ill patients (and healthy people) controlling for age, gender and social class. With increasing age, a high internal locus of control is also significantly less likely. When comparing healthy people, the chronically ill and the DMP participants a social gradient of a high internal locus of control belief can be observed. The weaker internal and higher doctor-related external locus of control of DMP participants should be carefully observed by the physician when trying to strengthen the patients' self-management skills. Evaluators of DMP should take into account the different baselines of DMP patients and relevant control groups and incorporate these differences into the evaluation. © Georg Thieme Verlag KG Stuttgart · New York.

  17. Copy number variation and transposable elements feature in recent, ongoing adaptation at the Cyp6g1 locus.

    Science.gov (United States)

    Schmidt, Joshua M; Good, Robert T; Appleton, Belinda; Sherrard, Jayne; Raymant, Greta C; Bogwitz, Michael R; Martin, Jon; Daborn, Phillip J; Goddard, Mike E; Batterham, Philip; Robin, Charles

    2010-06-24

    The increased transcription of the Cyp6g1 gene of Drosophila melanogaster, and consequent resistance to insecticides such as DDT, is a widely cited example of adaptation mediated by cis-regulatory change. A fragment of an Accord transposable element inserted upstream of the Cyp6g1 gene is causally associated with resistance and has spread to high frequencies in populations around the world since the 1940s. Here we report the existence of a natural allelic series at this locus of D. melanogaster, involving copy number variation of Cyp6g1, and two additional transposable element insertions (a P and an HMS-Beagle). We provide evidence that this genetic variation underpins phenotypic variation, as the more derived the allele, the greater the level of DDT resistance. Tracking the spatial and temporal patterns of allele frequency changes indicates that the multiple steps of the allelic series are adaptive. Further, a DDT association study shows that the most resistant allele, Cyp6g1-[BP], is greatly enriched in the top 5% of the phenotypic distribution and accounts for approximately 16% of the underlying phenotypic variation in resistance to DDT. In contrast, copy number variation for another candidate resistance gene, Cyp12d1, is not associated with resistance. Thus the Cyp6g1 locus is a major contributor to DDT resistance in field populations, and evolution at this locus features multiple adaptive steps occurring in rapid succession.

  18. Copy number variation and transposable elements feature in recent, ongoing adaptation at the Cyp6g1 locus.

    Directory of Open Access Journals (Sweden)

    Joshua M Schmidt

    2010-06-01

    Full Text Available The increased transcription of the Cyp6g1 gene of Drosophila melanogaster, and consequent resistance to insecticides such as DDT, is a widely cited example of adaptation mediated by cis-regulatory change. A fragment of an Accord transposable element inserted upstream of the Cyp6g1 gene is causally associated with resistance and has spread to high frequencies in populations around the world since the 1940s. Here we report the existence of a natural allelic series at this locus of D. melanogaster, involving copy number variation of Cyp6g1, and two additional transposable element insertions (a P and an HMS-Beagle. We provide evidence that this genetic variation underpins phenotypic variation, as the more derived the allele, the greater the level of DDT resistance. Tracking the spatial and temporal patterns of allele frequency changes indicates that the multiple steps of the allelic series are adaptive. Further, a DDT association study shows that the most resistant allele, Cyp6g1-[BP], is greatly enriched in the top 5% of the phenotypic distribution and accounts for approximately 16% of the underlying phenotypic variation in resistance to DDT. In contrast, copy number variation for another candidate resistance gene, Cyp12d1, is not associated with resistance. Thus the Cyp6g1 locus is a major contributor to DDT resistance in field populations, and evolution at this locus features multiple adaptive steps occurring in rapid succession.

  19. Transcription is required to establish maternal imprinting at the Prader-Willi syndrome and Angelman syndrome locus.

    Directory of Open Access Journals (Sweden)

    Emily Y Smith

    2011-12-01

    Full Text Available The Prader-Willi syndrome (PWS [MIM 17620] and Angelman syndrome (AS [MIM 105830] locus is controlled by a bipartite imprinting center (IC consisting of the PWS-IC and the AS-IC. The most widely accepted model of IC function proposes that the PWS-IC activates gene expression from the paternal allele, while the AS-IC acts to epigenetically inactivate the PWS-IC on the maternal allele, thus silencing the paternally expressed genes. Gene order and imprinting patterns at the PWS/AS locus are well conserved from human to mouse; however, a murine AS-IC has yet to be identified. We investigated a potential regulatory role for transcription from the Snrpn alternative upstream exons in silencing the maternal allele using a murine transgene containing Snrpn and three upstream exons. This transgene displayed appropriate imprinted expression and epigenetic marks, demonstrating the presence of a functional AS-IC. Transcription of the upstream exons from the endogenous locus correlates with imprint establishment in oocytes, and this upstream exon expression pattern was conserved on the transgene. A transgene bearing targeted deletions of each of the three upstream exons exhibited loss of imprinting upon maternal transmission. These results support a model in which transcription from the Snrpn upstream exons directs the maternal imprint at the PWS-IC.

  20. DNA methylation-independent removable insulator controls chromatin remodeling at the HOXA locus via retinoic acid signaling.

    Science.gov (United States)

    Ishihara, Ko; Nakamoto, Masafumi; Nakao, Mitsuyoshi

    2016-12-15

    Chromatin insulators partition the genome into functional units to control gene expression, particularly in complex chromosomal regions. The CCCTC-binding factor (CTCF) is an insulator-binding protein that functions in transcriptional regulation and higher-order chromatin formation. Variable CTCF-binding sites have been identified to be cell type-specific partly due to differential DNA methylation. Here, we show that DNA methylation-independent removable CTCF insulator is responsible for retinoic acid (RA)-mediated higher-order chromatin remodeling in the human HOXA gene locus. Detailed chromatin analysis characterized multiple CTCF-enriched sites and RA-responsive enhancers at this locus. These regulatory elements and transcriptionally silent HOXA genes are closely positioned under basal conditions. Notably, upon RA signaling, the RAR/RXR transcription factor induced loss of adjacent CTCF binding and changed the higher-order chromatin conformation of the overall locus. Targeted disruption of a CTCF site by genome editing with zinc finger nucleases and CRISPR/Cas9 system showed that the site is required for chromatin conformations that maintain the initial associations among insulators, enhancers and promoters. The results indicate that the initial chromatin conformation affects subsequent RA-induced HOXA gene activation. Our study uncovers that a removable insulator spatiotemporally switches higher-order chromatin and multiple gene activities via cooperation of CTCF and key transcription factors. © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  1. La tríada oscura de la personalidad: maquiavelismo, narcisismo y psicopatía. Una mirada evolutiva

    Directory of Open Access Journals (Sweden)

    Fernando Renee González Moraga

    2015-08-01

    Full Text Available Se aborda la denominada Tríada Oscura de la Personalidad -Tríada- (maquiavelismo, narcisismo subclínico y psicopatía subclínica desde una mirada evolutiva. El objetivo de esta investigación es revisar la evidencia que han presentado los teóricos evolucionistas sobre la Tríada, desde un acercamiento a la mirada evolutiva. Para esto, se indaga en las principales características de cada uno de estos rasgos, los instrumentos que se han utilizado para evaluarlos y las principales áreas en donde se han estudiado. La mirada evolutiva plantea que los rasgos de la Tríada son dimensionales y varían de acuerdo con las diversas estrategias que utilizan los sujetos para adaptarse a las características socioambientales en las que se desarrollan. Estos rasgos se caracterizan por presentar violencia psicológica, inhibición moral, manipulación, baja amabilidad, insensibilidad, egoísmo y dificultad para mentalizar en contextos de interacción interpersonal y social.

  2. Proceedings of the Annual Conference on Ada (Trademark) Technology (2nd) Held at Hampton, Virginia on March 27, 28, 1984.

    Science.gov (United States)

    1984-03-01

    irnportant arena to help insure the elt Mato success of Ada. Biographical Sketch Mr. Dennis J. Turner holds BSEE and MSEE degrees from j Monmouth College...to develop homework assignments. 3.4 Search for Related Courses 3.5 Do Not Forget the Prerequisites A language course without parallel courses in

  3. Software Technology for Adaptable, Reliable Systems (STARS). Repository Integration AdaKNET Software User’s Manual

    Science.gov (United States)

    1990-10-03

    knowledge bases via amalgama - tion of small, special-ptupose knowledge bases. For example, a fragment of the Gadfly knowledge base describing Ada...amalgamations must have as their root concept a generic con- cept which exists in the current network specification. The interpretation of amalgama - tons is

  4. Ada Compiler Validation Summary Report. TeleGen2, Version 3.7. MicroVAX II Model 630-QY and VAX-11/780.

    Science.gov (United States)

    1986-04-10

    Ant 1966 at Teleoft, .an Dilo CA, mdw the auspioes of the Ada Validation Faoility (AVF) at qrigt t-atterxc W A r e Smog ASO/SOL, acoording to Ada...Version 3.7 was submitted to the AVW-VPAF$ by the applicant for pro-validation review. Analysis of these results demonstrated that the oempler

  5. 78 FR 44279 - Regulatory Agenda

    Science.gov (United States)

    2013-07-23

    ... July 23, 2013 Part XI Department of Justice Semiannual Regulatory Agenda #0;#0;Federal Register / Vol... CFR Ch. I 27 CFR Ch. II 28 CFR Ch. I, V Regulatory Agenda AGENCY: Department of Justice. ACTION: Semiannual regulatory agenda. SUMMARY: The Department of Justice is publishing its spring 2013 regulatory...

  6. 77 FR 8018 - Regulatory Agenda

    Science.gov (United States)

    2012-02-13

    ... February 13, 2012 Part XVIII National Aeronautics and Space Administration Semiannual Regulatory Agenda #0... AERONAUTICS AND SPACE ADMINISTRATION 14 CFR Ch. V Regulatory Agenda AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Semiannual regulatory agenda. SUMMARY: NASA's regulatory agenda describes those...

  7. 75 FR 79759 - Regulatory Agenda

    Science.gov (United States)

    2010-12-20

    ... Energy ###Semiannual Regulatory Agenda### ] DEPARTMENT OF ENERGY (DOE) DEPARTMENT OF ENERGY Semiannual Regulatory Agenda 10 CFR Chs. II, III, and X 48 CFR Ch. 9 Regulatory Agenda AGENCY: Department of Energy. ACTION: Notice of semiannual regulatory agenda. SUMMARY: The Department of Energy (DOE) has prepared and...

  8. 78 FR 1634 - Regulatory Agenda

    Science.gov (United States)

    2013-01-08

    ... January 8, 2013 Part XVII National Aeronautics and Space Administration Semiannual Regulatory Agenda #0;#0... AERONAUTICS AND SPACE ADMINISTRATION 14 CFR Ch. V Regulatory Agenda AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Semiannual regulatory agenda. SUMMARY: NASA's regulatory agenda describes those...

  9. 75 FR 79799 - Regulatory Agenda

    Science.gov (United States)

    2010-12-20

    ... Justice ###Semiannual Regulatory Agenda### ] DEPARTMENT OF JUSTICE (DOJ) DEPARTMENT OF JUSTICE 8 CFR Ch. V 21 CFR Ch. I 27 CFR Ch. II 28 CFR Ch. I, V Regulatory Agenda AGENCY: Department of Justice. ACTION: Semiannual regulatory agenda. SUMMARY: The Department of Justice is publishing its fall 2010 regulatory...

  10. 77 FR 7972 - Regulatory Agenda

    Science.gov (United States)

    2012-02-13

    ... February 13, 2012 Part XI Department of Justice Semiannual Regulatory Agenda #0;#0;Federal Register / Vol... CFR Ch. I 27 CFR Ch. II 28 CFR Ch. I, V Regulatory Agenda AGENCY: Department of Justice. ACTION: Semiannual regulatory agenda. SUMMARY: The Department of Justice is publishing its fall 2011 regulatory...

  11. 78 FR 44329 - Regulatory Agenda

    Science.gov (United States)

    2013-07-23

    ... July 23, 2013 Part XVIII National Aeronautics and Space Administration Semiannual Regulatory Agenda #0... AERONAUTICS AND SPACE ADMINISTRATION 14 CFR Ch. V Regulatory Agenda AGENCY: National Aeronautics and Space Administration (NASA). ACTION: Semiannual regulatory agenda. SUMMARY: NASA's regulatory agenda describes those...

  12. Fast automatic 3D liver segmentation based on a three-level AdaBoost-guided active shape model

    Energy Technology Data Exchange (ETDEWEB)

    He, Baochun; Huang, Cheng; Zhou, Shoujun; Hu, Qingmao; Jia, Fucang, E-mail: fc.jia@siat.ac.cn [Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055 (China); Sharp, Gregory [Department of Radiation Oncology, Massachusetts General Hospital, Boston, Massachusetts 02114 (United States); Fang, Chihua; Fan, Yingfang [Department of Hepatology (I), Zhujiang Hospital, Southern Medical University, Guangzhou 510280 (China)

    2016-05-15

    Purpose: A robust, automatic, and rapid method for liver delineation is urgently needed for the diagnosis and treatment of liver disorders. Until now, the high variability in liver shape, local image artifacts, and the presence of tumors have complicated the development of automatic 3D liver segmentation. In this study, an automatic three-level AdaBoost-guided active shape model (ASM) is proposed for the segmentation of the liver based on enhanced computed tomography images in a robust and fast manner, with an emphasis on the detection of tumors. Methods: The AdaBoost voxel classifier and AdaBoost profile classifier were used to automatically guide three-level active shape modeling. In the first level of model initialization, fast automatic liver segmentation by an AdaBoost voxel classifier method is proposed. A shape model is then initialized by registration with the resulting rough segmentation. In the second level of active shape model fitting, a prior model based on the two-class AdaBoost profile classifier is proposed to identify the optimal surface. In the third level, a deformable simplex mesh with profile probability and curvature constraint as the external force is used to refine the shape fitting result. In total, three registration methods—3D similarity registration, probability atlas B-spline, and their proposed deformable closest point registration—are used to establish shape correspondence. Results: The proposed method was evaluated using three public challenge datasets: 3Dircadb1, SLIVER07, and Visceral Anatomy3. The results showed that our approach performs with promising efficiency, with an average of 35 s, and accuracy, with an average Dice similarity coefficient (DSC) of 0.94 ± 0.02, 0.96 ± 0.01, and 0.94 ± 0.02 for the 3Dircadb1, SLIVER07, and Anatomy3 training datasets, respectively. The DSC of the SLIVER07 testing and Anatomy3 unseen testing datasets were 0.964 and 0.933, respectively. Conclusions: The proposed automatic approach

  13. PENGARUH LOCUS OF CONTROL INTERNAL, LOCUS OF CONTROL EKSTERNAL, MANAJEMEN WAKTU, DAN KREATIVITAS MENGAJAR TERHADAP MOTIVASI BERPRESTASI

    Directory of Open Access Journals (Sweden)

    Dita Alfitami

    2017-10-01

    Full Text Available The aims of this research were to know the influence of the internal locus of control, external locus of control, time management, and teaching creativity to achievement motivation (case study in introduction to Office Administration subject in class XI AP SMK N 1 Kendal lesson school year 2016/2017.The population in this study were all the tenth graders of the Office Administration study program at SMK Negeri 1 Kendal with the total number of 71 students. While the sample taken used was saturated samples because the population were less than 100 respondents. Data collection method used in this research, which use questionnaire. The data analysis using multiple linear regression analysis method, classic assumption test analysis, percentage descriptive analysis, and hypothesis test analysis with the help of SPSS 21 programs. The finding shows the results of multiple linear regression analysis obtained equation Y = -20,466 + 0,431 X1 + 0,301 X2 + 0,357 X3 + 0,364 X4+ e. Test of significance of regression equation with F test, obtained count = 43,846 with significance0.000 and less than 0,05. The amount of influence simultaneously or together from locus of control, external locus of control, time management, and teaching creativity to achievement motivation was71%. While influence in partial or individually for internal locus of control was 23,52%, external locus of control 12,67%, time management 22,84%, and teaching creativity 22,46%.

  14. Volcanic geomorphosites and geotourism in Las Cañadas del Teide National Park, Tenerife, Canary Islands, Spain

    Science.gov (United States)

    Dóniz-Paéz, Javier; Becerra-Ramírez, Rafael; González-Cárdenas, Elena; Rodriguez, Fátima

    2017-04-01

    Geomorphosites and geoturism studies are increasing for the high scientific, societal, cultural, and aesthetic values of the relief. Volcanic areas are exciting targets for such studies for their geodiversity. The aim of these study is an inventory of volcanic geomorphosites and its relationship to geotourism. Las Cañadas del Teide National Park (LCTNP) is a volcanic complex area located in the central part of Tenerife island (Canary Islands, Spain). This area is a volcanic paradise rich in spectacular landforms: stratovolcanoes, calderas, cinder cones, craters, pahoehoe, aa, block and balls lavas, gullies, etc. The national park is registered in the world heritage list (UNESCO) in 2007 as a natural site. The LCTNP receives more than 2,5 million tourists per year and it has 21 main pahts and 14 secondary ones. For the selection of the geomophosites the LCTNP was divided into four geomorphological units (Teide-Pico Viejo stratovolcanoes, Las Cañadas Caldera wall, the bottom of Las Cañadas and the basaltic volcanic field) and each one of them is selected the most representative geomorphosites by its geodiversity, because of its geomorphological heritage, its landscapes and its tourist potential with the paths. All selected geomorphosites are within areas where public use is allowed in the park. The inventory classifies the 23 geomorphosites in two main categories: (a) direct volcanic with 17 geomorphosites (stratovolcanoes, domes, cinder cones, pahoehoe, aa and bloc lava flows, etc.) and (b) eroded volcanic landforms with 6 (wall of Las Cañadas caldera, talusees, foodplains, etc.). The Teide-Pico Viejo unit is which has more geomorphosites with 8 and the Las Cañadas wall unit possessing less with 5. The assessment evaluates the scientific, cultural/historical, and use values and helps to define priorities in site management. These geomorphosites demonstrate the volcanic history and processes of the LCTNP.

  15. Balancing Selection on a Regulatory Region Exhibiting Ancient Variation That Predates Human–Neandertal Divergence

    Science.gov (United States)

    Iskow, Rebecca C.; Austermann, Christian; Scharer, Christopher D.; Raj, Towfique; Boss, Jeremy M.; Sunyaev, Shamil; Price, Alkes; Stranger, Barbara; Simon, Viviana; Lee, Charles

    2013-01-01

    Ancient population structure shaping contemporary genetic variation has been recently appreciated and has important implications regarding our understanding of the structure of modern human genomes. We identified a ∼36-kb DNA segment in the human genome that displays an ancient substructure. The variation at this locus exists primarily as two highly divergent haplogroups. One of these haplogroups (the NE1 haplogroup) aligns with the Neandertal haplotype and contains a 4.6-kb deletion polymorphism in perfect linkage disequilibrium with 12 single nucleotide polymorphisms (SNPs) across diverse populations. The other haplogroup, which does not contain the 4.6-kb deletion, aligns with the chimpanzee haplotype and is likely ancestral. Africans have higher overall pairwise differences with the Neandertal haplotype than Eurasians do for this NE1 locus (p<10−15). Moreover, the nucleotide diversity at this locus is higher in Eurasians than in Africans. These results mimic signatures of recent Neandertal admixture contributing to this locus. However, an in-depth assessment of the variation in this region across multiple populations reveals that African NE1 haplotypes, albeit rare, harbor more sequence variation than NE1 haplotypes found in Europeans, indicating an ancient African origin of this haplogroup and refuting recent Neandertal admixture. Population genetic analyses of the SNPs within each of these haplogroups, along with genome-wide comparisons revealed significant FST (p = 0.00003) and positive Tajima's D (p = 0.00285) statistics, pointing to non-neutral evolution of this locus. The NE1 locus harbors no protein-coding genes, but contains transcribed sequences as well as sequences with putative regulatory function based on bioinformatic predictions and in vitro experiments. We postulate that the variation observed at this locus predates Human–Neandertal divergence and is evolving under balancing selection, especially among European populations. PMID

  16. Balancing selection on a regulatory region exhibiting ancient variation that predates human-neandertal divergence.

    Directory of Open Access Journals (Sweden)

    Omer Gokcumen

    2013-04-01

    Full Text Available Ancient population structure shaping contemporary genetic variation has been recently appreciated and has important implications regarding our understanding of the structure of modern human genomes. We identified a ∼36-kb DNA segment in the human genome that displays an ancient substructure. The variation at this locus exists primarily as two highly divergent haplogroups. One of these haplogroups (the NE1 haplogroup aligns with the Neandertal haplotype and contains a 4.6-kb deletion polymorphism in perfect linkage disequilibrium with 12 single nucleotide polymorphisms (SNPs across diverse populations. The other haplogroup, which does not contain the 4.6-kb deletion, aligns with the chimpanzee haplotype and is likely ancestral. Africans have higher overall pairwise differences with the Neandertal haplotype than Eurasians do for this NE1 locus (p<10⁻¹⁵. Moreover, the nucleotide diversity at this locus is higher in Eurasians than in Africans. These results mimic signatures of recent Neandertal admixture contributing to this locus. However, an in-depth assessment of the variation in this region across multiple populations reveals that African NE1 haplotypes, albeit rare, harbor more sequence variation than NE1 haplotypes found in Europeans, indicating an ancient African origin of this haplogroup and refuting recent Neandertal admixture. Population genetic analyses of the SNPs within each of these haplogroups, along with genome-wide comparisons revealed significant FST (p = 0.00003 and positive Tajima's D (p = 0.00285 statistics, pointing to non-neutral evolution of this locus. The NE1 locus harbors no protein-coding genes, but contains transcribed sequences as well as sequences with putative regulatory function based on bioinformatic predictions and in vitro experiments. We postulate that the variation observed at this locus predates Human-Neandertal divergence and is evolving under balancing selection, especially among European

  17. Rationales for regulatory activity

    Energy Technology Data Exchange (ETDEWEB)

    Perhac, R.M. [Univ. of Tennessee, Knoxville, TN (United States)

    1997-02-01

    The author provides an outline which touches on the types of concerns about risk evaluation which are addressed in the process of establishing regulatory guides. Broadly he says regulatory activity serves three broad constituents: (1) Paternalism (private risk); (2) Promotion of social welfare (public risks); (3) Protection of individual rights (public risks). He then discusses some of the major issues encountered in reaching a decision on what is an acceptable level of risk within each of these areas, and how one establishes such a level.

  18. Prediction of regulatory elements

    DEFF Research Database (Denmark)

    Sandelin, Albin

    2008-01-01

    Finding the regulatory mechanisms responsible for gene expression remains one of the most important challenges for biomedical research. A major focus in cellular biology is to find functional transcription factor binding sites (TFBS) responsible for the regulation of a downstream gene. As wet......-lab methods are time consuming and expensive, it is not realistic to identify TFBS for all uncharacterized genes in the genome by purely experimental means. Computational methods aimed at predicting potential regulatory regions can increase the efficiency of wet-lab experiments significantly. Here, methods...

  19. Inferring Demographic History Using Two-Locus Statistics.

    Science.gov (United States)

    Ragsdale, Aaron P; Gutenkunst, Ryan N

    2017-06-01

    Population demographic history may be learned from contemporary genetic variation data. Methods based on aggregating the statistics of many single loci into an allele frequency spectrum (AFS) have proven powerful, but such methods ignore potentially informative patterns of linkage disequilibrium (LD) between neighboring loci. To leverage such patterns, we developed a composite-likelihood framework for inferring demographic history from aggregated statistics of pairs of loci. Using this framework, we show that two-locus statistics are more sensitive to demographic history than single-locus statistics such as the AFS. In particular, two-locus statistics escape the notorious confounding of depth and duration of a bottleneck, and they provide a means to estimate effective population size based on the recombination rather than mutation rate. We applied our approach to a Zambian population of Drosophila melanogaster Notably, using both single- and two-locus statistics, we inferred a substantially lower ancestral effective population size than previous works and did not infer a bottleneck history. Together, our results demonstrate the broad potential for two-locus statistics to enable powerful population genetic inference. Copyright © 2017 by the Genetics Society of America.

  20. Impulsiveness, locus of control, motivation and problem gambling.

    Science.gov (United States)

    Clarke, Dave

    2004-01-01

    A questionnaire consisting of demographic items, questions about gambling behavior, the South Oaks Gambling Screen (SOGS), a depression inventory, the Eysenck Impulsiveness Questionnaire, Levenson's Internality, Powerful Others and Chance Scales of locus of control and the Gambling Motivation Scale, was completed by a non-random sample of 147 New Zealand university students who gambled for money, median age 24 years. Approximately 17 of the sample was classified as problem gamblers, the rest as non-problem gamblers. Multivariate analysis of variance showed that there were significant differences between problem and non-problem gamblers on gambling frequency, number of activities, parents' gambling, depression, impulsiveness and motivation, but not on locus of control. Amotivation (apathy) and motivation towards stimulation correlated with powerful others and chance locus of control, and motivation to impress others with powerful others locus of control. Hierarchical regression analysis showed that: (1) beyond gambling frequency, number of activities and parents' gambling, motivation explained a substantial proportion of variance in SOGS scores, with impulsiveness accounting for a lesser amount, and (2) predictors of problem gambling included impulsiveness, amotivation and the motivations for accomplishment and tension release. It was concluded that gambling motivation is a more useful construct than locus of control in explaining problem gambling. Suggestions were made for future research, and aspects of gambling motivation were discussed in terms of a treatment program with groups of problem gamblers.

  1. Mutation at the Human D1S80 Minisatellite Locus

    Directory of Open Access Journals (Sweden)

    Kuppareddi Balamurugan

    2012-01-01

    Full Text Available Little is known about the general biology of minisatellites. The purpose of this study is to examine repeat mutations from the D1S80 minisatellite locus by sequence analysis to elucidate the mutational process at this locus. This is a highly polymorphic minisatellite locus, located in the subtelomeric region of chromosome 1. We have analyzed 90,000 human germline transmission events and found seven (7 mutations at this locus. The D1S80 alleles of the parentage trio, the child, mother, and the alleged father were sequenced and the origin of the mutation was determined. Using American Association of Blood Banks (AABB guidelines, we found a male mutation rate of 1.04×10-4 and a female mutation rate of 5.18×10-5 with an overall mutation rate of approximately 7.77×10-5. Also, in this study, we found that the identified mutations are in close proximity to the center of the repeat array rather than at the ends of the repeat array. Several studies have examined the mutational mechanisms of the minisatellites according to infinite allele model (IAM and the one-step stepwise mutation model (SMM. In this study, we found that this locus fits into the one-step mutation model (SMM mechanism in six out of seven instances similar to STR loci.

  2. A two-locus forensic match probability for subdivided populations.

    Science.gov (United States)

    Ayres, K L

    2000-01-01

    A two-locus match probability is presented that incorporates the effects of within-subpopulation inbreeding (consanguinity) in addition to population subdivision. The usual practice of calculating multi-locus match probabilities as the product of single-locus probabilities assumes independence between loci. There are a number of population genetics phenomena that can violate this assumption: in addition to consanguinity, which increases homozygosity at all loci simultaneously, gametic disequilibrium will introduce dependence into DNA profiles. However, in forensics the latter problem is usually addressed in part by the careful choice of unlinked loci. Hence, as is conventional, we assume gametic equilibrium here, and focus instead on between-locus dependence due to consanguinity. The resulting match probability formulae are an extension of existing methods in the literature, and are shown to be more conservative than these methods in the case of double homozygote matches. For two-locus profiles involving one or more heterozygous genotypes, results are similar to, or smaller than, the existing approaches.

  3. The ADA*2 Allele of the Adenosine Deaminase Gene and Recurrent Spontaneous Abortions in Northwest of Iran

    Directory of Open Access Journals (Sweden)

    M Bonyadi

    2015-06-01

    Full Text Available Background & objectives: Recurrent spontaneous abortion (RSA is defined by two or more consecutive miscarriages before 20 weeks of gestation. Adenosine deaminase (ADA is an enzyme of purine salvage pathway and has two important isoenzymes ADA1 and ADA2. The adenosine deaminase G22A polymorphism (ADA*2 increases the level of adenosine. Adenosine may play a protective role against recurrent spontaneous abortions, since it regulates blood flow into the uterus and placenta. In consideration of the effect of decreased enzymatic activity of adenosine deaminase G22A polymorphism on adenosine levels we evaluated the protective effect of ADA*2 allele against recurrent spontaneous abortions in north-west of Iran.  Methods: A total of 100 women were recruited to form two groups. First one, with a history of recurrent spontaneous abortions (N=50, and the second one, without a history of abortions (N=50. Genomic DNA was extracted from peripheral blood with a commercial kit and PCR-RFLP analysis was used to identify the G22A genetic polymorphism. Fisher's exact test and odds ratio values were used to compare the proportions of adenosine deaminase genotypes and alleles between women with and without a history of recurrent spontaneous abortion (p<0.05.  Results: The frequency of homozygotes (AA was 2% in control group, whereas no homozygote (AA was found in the case group. The frequency of heterozygotes (AG was 20% in control group and 8% in the case group (p<0.05. The frequency of homozygotes (GG was 78% in control group and 92% in the case group (p<0. 05. A significant increase in the frequency of AG genotype in controls (p=0.014, OR=0.348 relative to women with the history of RSA demonstrates the protective effect of AG genotype in controls. Conclusion: The data suggest that women carrying the G22A polymorphism (ADA*2 allele and AG genotype which is associated with the lower enzymatic activity are better protected against recurrent spontaneous abortions.

  4. ADA Title I allegations and the Mining, Quarrying, and Oil/Gas Extraction industry.

    Science.gov (United States)

    Van Wieren, Todd A; Rhoades, Laura; McMahon, Brian T

    2017-01-01

    The majority of research about employment discrimination in the U.S. Mining, Quarrying, and Oil/Gas (MQOGE) industries has concentrated on gender and race, while little attention has focused on disability. To explore allegations of Americans with Disabilities Act (ADA) Title I discrimination made to the Equal Employment Opportunity Commission (EEOC) by individuals with disabilities against MQOGE employers. Key data available to this study included demographic characteristics of charging parties, size of employers, types of allegations, and case outcomes. Using descriptive analysis, allegation profiles were developed for MQOGE's three main sectors (i.e., Oil/Gas Extraction, Mining except Oil/Gas, and Support Activities). These three profiles where then comparatively analyzed. Lastly, regression analysis explored whether some of the available data could partially predict MQOGE case outcomes. The predominant characteristics of MQOGE allegations were found to be quite similar to the allegation profile of U.S. private-sector industry as a whole, and fairly representative of MQOGE's workforce demographics. Significant differences between MQOGE's three main sector profiles were noted on some important characteristics. Lastly, it was found that MQOGE case outcomes could be partially predicted via some of the available variables. The study's limitations were presented and recommendations were offered for further research.

  5. Fusion of Optimized Indicators from Advanced Driver Assistance Systems (ADAS) for Driver Drowsiness Detection

    Science.gov (United States)

    Daza, Iván G.; Bergasa, Luis M.; Bronte, Sebastián; Yebes, J. Javier; Almazán, Javier; Arroyo, Roberto

    2014-01-01

    This paper presents a non-intrusive approach for monitoring driver drowsiness using the fusion of several optimized indicators based on driver physical and driving performance measures, obtained from ADAS (Advanced Driver Assistant Systems) in simulated conditions. The paper is focused on real-time drowsiness detection technology rather than on long-term sleep/awake regulation prediction technology. We have developed our own vision system in order to obtain robust and optimized driver indicators able to be used in simulators and future real environments. These indicators are principally based on driver physical and driving performance skills. The fusion of several indicators, proposed in the literature, is evaluated using a neural network and a stochastic optimization method to obtain the best combination. We propose a new method for ground-truth generation based on a supervised Karolinska Sleepiness Scale (KSS). An extensive evaluation of indicators, derived from trials over a third generation simulator with several test subjects during different driving sessions, was performed. The main conclusions about the performance of single indicators and the best combinations of them are included, as well as the future works derived from this study. PMID:24412904

  6. Lagu ABC (Ada Banyak Cara Karya Trio Bimbo Dalam Analisis Wacana Michel Foucault

    Directory of Open Access Journals (Sweden)

    Ubaidillah Ubaidillah

    2016-08-01

    Full Text Available This paper examines a song criticizing the phenomenon that occurs in the body of the government of Indonesia nowadays. Lyric of a song ABC (Ada Banyak Cara by Trio Bimbo that becomes the focus of study in this paper is interesting to be studied, considering the Trio Bimbo is famous musicians who focused on religious themes, voicing out his heart in criticizing the government.The discourse theory of Michel Foucault,in which his discourse of language is closely related to who is in power in the region, is used to analyze this song.The result founds that the discourse of language in the ABC song is representation the mercy of the people, in this case represented by Trio Bimbo sound, such as naikkan gaji sendiri, duduk sidang terus mimpi, jaksa hakim wiraswasta, and other discordant expressions that criticize the government. Trio Bimbo does not hesitate to cast his criticism of the government by voicing the discourse of language which is considered as a direct criticism, without the subtle innuendo. If this happens in the Orde Baru era, the discourse of language must be prohibited by the government, because they were in power at that time. However, after the fall of Orde Baru, resime people have the power to create their own linguistic discourse.

  7. Radon and helium in soil gases at Cañadas caldera, Tenerife, Canary Islands, Spain

    Science.gov (United States)

    Hernández, Pedro; Pérez, Nemesio; Salazar, José; Reimer, Mike; Notsu, Kenji; Wakita, Hiroshi

    2004-03-01

    The spatial distribution of soil radon was investigated at Cañadas caldera, Tenerife, in two surveys carried out in the summers of 1992 and 1995 by using α-particle-sensitive cellulose nitrate films (Track-Etch) and emanometry, respectively. Soil helium was studied at several transects crossing different structural features of the area. Radon concentration measured by Track-Etch ranged from 1.0 to 1990 pCi/l while that measured by emanometry ranged from 0.1 to 618 pCi/l. Soil helium concentration varied from 5250 to 15 560 ppb with an average value of 6197 ppb. The spatial distribution of soil radon correlates quite closely with structural features (fractures, emission centers, etc.), where the main geothermal manifestations (fumaroles, steam ground and high subsurface temperature and gas contents) also occur. Areas showing high soil Rn concentrations occur at the summit of Teide, Roques de Garcı´a, caldera rim and south and east off side of the caldera. High soil helium anomalies correlate well spatially with those of radon, especially at the summit of Teide where relatively high 3He/ 4He isotopic ratios occur, suggesting a deep contribution for these emanations. Data indicate that radon and helium are supplied mostly from a deep source, with a minor contribution from U- and Th-rich shallow rocks and soils.

  8. Conformational Flexibility and Subunit Arrangement of the Modular Yeast Spt-Ada-Gcn5 Acetyltransferase Complex*

    Science.gov (United States)

    Setiaputra, Dheva; Ross, James D.; Lu, Shan; Cheng, Derrick T.; Dong, Meng-Qiu; Yip, Calvin K.

    2015-01-01

    The Spt-Ada-Gcn5 acetyltransferase (SAGA) complex is a highly conserved, 19-subunit histone acetyltransferase complex that activates transcription through acetylation and deubiquitination of nucleosomal histones in Saccharomyces cerevisiae. Because SAGA has been shown to display conformational variability, we applied gradient fixation to stabilize purified SAGA and systematically analyzed this flexibility using single-particle EM. Our two- and three-dimensional studies show that SAGA adopts three major conformations, and mutations of specific subunits affect the distribution among these. We also located the four functional modules of SAGA using electron microscopy-based labeling and transcriptional activator binding analyses and show that the acetyltransferase module is localized in the most mobile region of the complex. We further comprehensively mapped the subunit interconnectivity of SAGA using cross-linking mass spectrometry, revealing that the Spt and Taf subunits form the structural core of the complex. These results provide the necessary restraints for us to generate a model of the spatial arrangement of all SAGA subunits. According to this model, the chromatin-binding domains of SAGA are all clustered in one face of the complex that is highly flexible. Our results relate information of overall SAGA structure with detailed subunit level interactions, improving our understanding of its architecture and flexibility. PMID:25713136

  9. Conformational flexibility and subunit arrangement of the modular yeast Spt-Ada-Gcn5 acetyltransferase complex.

    Science.gov (United States)

    Setiaputra, Dheva; Ross, James D; Lu, Shan; Cheng, Derrick T; Dong, Meng-Qiu; Yip, Calvin K

    2015-04-17

    The Spt-Ada-Gcn5 acetyltransferase (SAGA) complex is a highly conserved, 19-subunit histone acetyltransferase complex that activates transcription through acetylation and deubiquitination of nucleosomal histones in Saccharomyces cerevisiae. Because SAGA has been shown to display conformational variability, we applied gradient fixation to stabilize purified SAGA and systematically analyzed this flexibility using single-particle EM. Our two- and three-dimensional studies show that SAGA adopts three major conformations, and mutations of specific subunits affect the distribution among these. We also located the four functional modules of SAGA using electron microscopy-based labeling and transcriptional activator binding analyses and show that the acetyltransferase module is localized in the most mobile region of the complex. We further comprehensively mapped the subunit interconnectivity of SAGA using cross-linking mass spectrometry, revealing that the Spt and Taf subunits form the structural core of the complex. These results provide the necessary restraints for us to generate a model of the spatial arrangement of all SAGA subunits. According to this model, the chromatin-binding domains of SAGA are all clustered in one face of the complex that is highly flexible. Our results relate information of overall SAGA structure with detailed subunit level interactions, improving our understanding of its architecture and flexibility. © 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

  10. Classification of patterns for diffuse lung diseases in thoracic CT images by AdaBoost algorithm

    Science.gov (United States)

    Kuwahara, Masayuki; Kido, Shoji; Shouno, Hayaru

    2009-02-01

    CT images are considered as effective for differential diagnosis of diffuse lung diseases. However, the diagnosis of diffuse lung diseases is a difficult problem for the radiologists, because they show a variety of patterns on CT images. So, our purpose is to construct a computer-aided diagnosis (CAD) system for classification of patterns for diffuse lung diseases in thoracic CT images, which gives both quantitative and objective information as a second opinion, to decrease the burdens of radiologists. In this article, we propose a CAD system based on the conventional pattern recognition framework, which consists of two sub-systems; one is feature extraction part and the other is classification part. In the feature extraction part, we adopted a Gabor filter, which can extract patterns such like local edges and segments from input textures, as a feature extraction of CT images. In the recognition part, we used a boosting method. Boosting is a kind of voting method by several classifiers to improve decision precision. We applied AdaBoost algorithm for boosting method. At first, we evaluated each boosting component classifier, and we confirmed they had not enough performances in classification of patterns for diffuse lung diseases. Next, we evaluated the performance of boosting method. As a result, by use of our system, we could improve the classification rate of patterns for diffuse lung diseases.

  11. Ada Compiler Validation Summary Report: Certificate Number: 881216N1. 10013, Alsys Limited, AlsyCOMP 013, Version 4.1, IBM PC/AT/IBM 9370 Model 90

    Science.gov (United States)

    1988-12-16

    identifies behaviour that is implementation-dependent but permitted by the Ada Standard. Six classes of tests are uggd-- These tests are designed to...determine that the implementation-dependent behaviour is allowed by the Ada Standard Testing of this compiler was conducted by The National Computing... nonconformities to the Ada Standard other than those presented. Copies of this report are available to the public from: Ada Information Clearinghouse

  12. AKT as Locus of Hydrogen Bond Network in Cancer.

    Science.gov (United States)

    Radisavljevic, Ziv

    2018-01-01

    Generation and maintenance of a cancer complexity and robustness are impossible without hydrogen element. It is essential element for the cancer signaling through the AKT locus. Hyperactivated AKT locus by a positive feedback loops from the cancer hypoxic microenvironment generates a hydrogen bond network. Such network initiates protein-protein interaction at the AKT active site and at the same time stabilizes signal propagation. A hydrogen bond network conforms an entropy/enthalpy energetic process used for the interconversion of the AKT protein in metastasis formation and maintenance. Targeting the AKT locus by the redox balance change or hydrogen balance change or proton beam radiation disrupts a hydrogen bond network leading to the disappearance of a cancer complexity and robustness causing failure of the complex energy system in solid cancers and hematological malignancy. J. Cell. Biochem. 119: 130-133, 2018. © 2017 Wiley Periodicals, Inc. © 2017 Wiley Periodicals, Inc.

  13. Lupus vulgaris occurring in a locus minoris resistentiae.

    Science.gov (United States)

    Long, Richard; Beatch, Anita; Lee, Mao-Cheng; Cheung-Lee, Melody; Wasel, Norman

    2009-01-01

    The pathogenesis of lupus vulgaris, a form of cutaneous tuberculosis, is not always clear, especially in patients who do not have coexistent extracutaneous tuberculosis and in patients with single lesions. To report a case of lupus vulgaris in a locus minoris resistentiae (a site of reduced resistance) and to use a unique set of clinical circumstances and laboratory tests to reconstruct the pathogenesis of the lesion and the response to treatment. Lupus vulgaris can occur in a locus minoris resistentiae; local trauma and possibly other factors, such as increased temperature, topical corticosteroids, and the virulence of the infecting strain, may facilitate the growth of Mycobacterium tuberculosis present at a locus minoris resistentiae as a result of a silent bacillemia.

  14. Parenting style, locus of control, and oral hygiene in adolescents.

    Science.gov (United States)

    Aleksejūnienė, Jolanta; Brukienė, Vilma

    2012-01-01

    The aim of the study was to test if variations in oral hygiene levels in adolescents were associated with locus of control and parenting styles after controlling for demographic factors. The study sample comprised 237 adolescents aged 12-13 years. The structured questionnaire included demographic characteristics and items about parenting style and locus of control. The Individual Quantitative Plaque % Index (IQPI) and toothbrushing frequency were used as clinical outcome measures. In the bivariate analyses, socioeconomic status (P=0.012), number of children in the family (P=0.003), and frequency of toothbrushing (P=0.001) were related to dental plaque levels. Gender (Pparenting styles, locus of control, and oral hygiene levels was not confirmed.

  15. ADa Compiler Validation Summary Report: Certificate Number 911107W1. 11227 Hewlett-Packard HP 9000 Series 700/800 Ada Compiler, Version 5.35 HP 9000 Series 700 Model 720 = HP 9000 Series 700 Model 720

    Science.gov (United States)

    1991-12-09

    Facility ASLi /SCEL Wright-Patterson AFB OH 45433-6503 92-04471 9 2 2 20 022 Certificate Information The following Ada implementation was tested and...following example illustrates the use of an enumeration representation clause. 4-2 F 4. Type Representation Example type COLOR is (RED, ORANGE , YELLOW...GREEN, AQUA, BLUE, VIOLET); for COLOR use (RED => 10, ORANGE => 20, YELLOW => 40, GREEN => 80, AQUA => 160, 4 BLUE => 320, VIOLET => 640); In the

  16. Locus-specific view of flax domestication history

    Science.gov (United States)

    Fu, Yong-Bi; Diederichsen, Axel; Allaby, Robin G

    2012-01-01

    Crop domestication has been inferred genetically from neutral markers and increasingly from specific domestication-associated loci. However, some crops are utilized for multiple purposes that may or may not be reflected in a single domestication-associated locus. One such example is cultivated flax (Linum usitatissimum L.), the earliest oil and fiber crop, for which domestication history remains poorly understood. Oil composition of cultivated flax and pale flax (L. bienne Mill.) indicates that the sad2 locus is a candidate domestication locus associated with increased unsaturated fatty acid production in cultivated flax. A phylogenetic analysis of the sad2 locus in 43 pale and 70 cultivated flax accessions established a complex domestication history for flax that has not been observed previously. The analysis supports an early, independent domestication of a primitive flax lineage, in which the loss of seed dispersal through capsular indehiscence was not established, but increased oil content was likely occurred. A subsequent flax domestication process occurred that probably involved multiple domestications and includes lineages that contain oil, fiber, and winter varieties. In agreement with previous studies, oil rather than fiber varieties occupy basal phylogenetic positions. The data support multiple paths of flax domestication for oil-associated traits before selection of the other domestication-associated traits of seed dispersal loss and fiber production. The sad2 locus is less revealing about the origin of winter tolerance. In this case, a single domestication-associated locus is informative about the history of domesticated forms with the associated trait while partially informative on forms less associated with the trait. PMID:22408732

  17. Changes in Adenosine Deaminase Activity in Patients with Type 2 Diabetes Mellitus and Effect of DPP-4 Inhibitor Treatment on ADA Activity

    Directory of Open Access Journals (Sweden)

    Jae-Geun Lee

    2011-04-01

    Full Text Available BackgroundDipeptidyl peptidase 4 (DPP-4, also known as CD26 binds with adenosine deaminase (ADA to activate T lymphocytes. Here, we investigated whether ADA activity is specifically affected by treatment with DPP-4 inhibitor (DPP4I compared with other anti-diabetic agents.MethodsFasting ADA activity, in addition to various metabolic and biochemical parameters, were measured in 262 type 2 diabetes mellitus (T2DM patients taking various anti-diabetic agents and in 46 non-diabetic control subjects.ResultsADA activity was increased in T2DM patients compared with that in non-diabetic control subjects (mean±standard error, 23.1±0.6 U/L vs. 18.6±0.8 U/L; P9% showed significantly increased ADA activity (21.1±0.8 U/L vs. 25.4±1.6 U/L; P<0.05. The effect of DPP4I on ADA activity in T2DM patients did not differ from those of other oral anti-diabetic agents or insulin. T2DM patients on metformin monotherapy showed a lower ADA activity (20.9±1.0 U/L vs. 28.1±2.8 U/L; P<0.05 compared with that of those on sulfonylurea monotherapy.ConclusionOur results show that ADA activity is increased in T2DM patients compared to that in non-diabetic patients, is positively correlated with blood glucose level, and that DPP4I has no additional specific effect on ADA activity, except for a glycemic control- or HbA1c-dependent effect.

  18. Microevolution of the chromosomal region of acute disease antigen A (adaA in the query (Q fever agent Coxiella burnetii.

    Directory of Open Access Journals (Sweden)

    Dimitrios Frangoulidis

    Full Text Available The acute disease antigen A (adaA gene is believed to be associated with Coxiella burnetii strains causing acute Q fever. The detailed analysis of the adaA genomic region of 23 human- and 86 animal-derived C. burnetii isolates presented in this study reveals a much more polymorphic appearance and distribution of the adaA gene, resulting in a classification of C. burnetii strains of better differentiation than previously anticipated. Three different genomic variants of the adaA gene were identified which could be detected in isolates from acute and chronic patients, rendering the association of adaA positive strains with acute Q fever disease disputable. In addition, all adaA positive strains in humans and animals showed the occurrence of the QpH1 plasmid. All adaA positive isolates of acute human patients except one showed a distinct SNP variation at position 431, also predominant in sheep strains, which correlates well with the observation that sheep are a major source of human infection. Furthermore, the phylogenetic analysis of the adaA gene revealed three deletion events and supported the hypothesis that strain Dugway 5J108-111 might be the ancestor of all known C. burnetii strains. Based on our findings, we could confirm the QpDV group and we were able to define a new genotypic cluster. The adaA gene polymorphisms shown here improve molecular typing of Q fever, and give new insights into microevolutionary adaption processes in C. burnetii.

  19. Analysis of the ABCA4 genomic locus in Stargardt disease

    DEFF Research Database (Denmark)

    Zernant, Jana; Xie, Yajing Angela; Ayuso, Carmen

    2014-01-01

    was designed to find the missing disease-causing ABCA4 variation by a combination of next-generation sequencing (NGS), array-Comparative Genome Hybridization (aCGH) screening, familial segregation and in silico analyses. The entire 140 kb ABCA4 genomic locus was sequenced in 114 STGD patients with one known...... excluded since they were not conserved in non-human primates, were frequent in African populations and, therefore, represented ancestral, and not disease-associated, variants. The sequence variability in the ABCA4 locus is extensive and the non-coding sequences do not harbor frequent mutations in STGD...

  20. Correlacional study among locus of control and human values

    OpenAIRE

    Saulo Santos Menezes Almeida

    2008-01-01

    O presente estudo teve como objetivo central analisar as relações entre locus de controle e valores. Participaram 355 universitários de Sergipe, a maioria do sexo feminino (62,8%) e solteiros (80%), com média de idade de 25,68 anos (amplitude de 17 a 56 anos). Os estudantes responderam à escala de locus de controle de Reyes e a escala de valores de Schwartz. Os resultados indicaram ser os instrumentos aptos a mensurar o proposto pelo objetivo, apresentando índices psicométricos satisfatórios....

  1. Hispanics' locus of control, acculturation, and wellness attitudes.

    Science.gov (United States)

    Valentine, Sean R; Godkin, Jennie; Doughty, Graeme P

    2008-01-01

    There is reason to believe that various cultural attitudes and beliefs influence certain health behaviors, and additional research should identify the causes of such behaviors. This study explored the relationships among cultural identity, acculturation, locus of control, and health beliefs using a sample of 110 Hispanic individuals taking college classes in the southern or southwestern United States. Path analysis indicated that an external locus of control was positively related to health barrier perceptions and that acculturation was negatively related to health barrier perceptions. The findings suggest that Hispanics' perceived control over health outcomes and positive health beliefs could be enhanced with culturally perceptive counseling.

  2. Relationship between preference for red and locus of control.

    Science.gov (United States)

    Singg, S; Whiddon, T L

    2000-08-01

    The validity of the assumptions about the color red in the Lüscher color theory were examined by correlating preference for red to locus of control and sex. Undergraduates (100 men and 100 women) who scored or = 16 on the Rotter Internal-External Locus of Control Scale were administered the short form of the Lüscher Color Test. Consistent with the assumptions by Lüscher about the color red, the analysis of variance showed that Internal scorers preferred red significantly more than External scorers, but no sex difference was found.

  3. Ada (Trade Name) Compiler Validation Summary Report: Alsys Inc., AlsyCOMP 003, V3.1, Wang PC 280.

    Science.gov (United States)

    1988-06-04

    constructs and that i.t identifies and rejects illegal language constructs. The testing also identifies behaviour that is implementation dependent but...test for which the compiler generates a result that demonstrates nonconformity to the Ada Standard. 1-3 % INTRODUCTION Host The computer on which the...INFORMATION 2.2 IMPLEMENTATION CHARACTERISTICS One of the purposes of validating compilers is to determine the behaviour of a compiler in those areas of the

  4. Functional footprinting of regulatory DNA.

    Science.gov (United States)

    Vierstra, Jeff; Reik, Andreas; Chang, Kai-Hsin; Stehling-Sun, Sandra; Zhou, Yuanyue; Hinkley, Sarah J; Paschon, David E; Zhang, Lei; Psatha, Nikoletta; Bendana, Yuri R; O'Neil, Colleen M; Song, Alexander H; Mich, Andrea K; Liu, Pei-Qi; Lee, Gary; Bauer, Daniel E; Holmes, Michael C; Orkin, Stuart H; Papayannopoulou, Thalia; Stamatoyannopoulos, George; Rebar, Edward J; Gregory, Philip D; Urnov, Fyodor D; Stamatoyannopoulos, John A

    2015-10-01

    Regulatory regions harbor multiple transcription factor (TF) recognition sites; however, the contribution of individual sites to regulatory function remains challenging to define. We describe an approach that exploits the error-prone nature of genome editing-induced double-strand break repair to map functional elements within regulatory DNA at nucleotide resolution. We demonstrate the approach on a human erythroid enhancer, revealing single TF recognition sites that gate the majority of downstream regulatory function.

  5. Heterotic trait locus (HTL mapping identifies intra-locus interactions that underlie reproductive hybrid vigor in Sorghum bicolor.

    Directory of Open Access Journals (Sweden)

    Imri Ben-Israel

    Full Text Available Identifying intra-locus interactions underlying heterotic variation among whole-genome hybrids is a key to understanding mechanisms of heterosis and exploiting it for crop and livestock improvement. In this study, we present the development and first use of the heterotic trait locus (HTL mapping approach to associate specific intra-locus interactions with an overdominant heterotic mode of inheritance in a diallel population using Sorghum bicolor as the model. This method combines the advantages of ample genetic diversity and the possibility of studying non-additive inheritance. Furthermore, this design enables dissecting the latter to identify specific intra-locus interactions. We identified three HTLs (3.5% of loci tested with synergistic intra-locus effects on overdominant grain yield heterosis in 2 years of field trials. These loci account for 19.0% of the heterotic variation, including a significant interaction found between two of them. Moreover, analysis of one of these loci (hDPW4.1 in a consecutive F2 population confirmed a significant 21% increase in grain yield of heterozygous vs. homozygous plants in this locus. Notably, two of the three HTLs for grain yield are in synteny with previously reported overdominant quantitative trait loci for grain yield in maize. A mechanism for the reproductive heterosis found in this study is suggested, in which grain yield increase is achieved by releasing the compensatory tradeoffs between biomass and reproductive output, and between seed number and weight. These results highlight the power of analyzing a diverse set of inbreds and their hybrids for unraveling hitherto unknown allelic interactions mediating heterosis.

  6. Heterotic trait locus (HTL) mapping identifies intra-locus interactions that underlie reproductive hybrid vigor in Sorghum bicolor.

    Science.gov (United States)

    Ben-Israel, Imri; Kilian, Benjamin; Nida, Habte; Fridman, Eyal

    2012-01-01

    Identifying intra-locus interactions underlying heterotic variation among whole-genome hybrids is a key to understanding mechanisms of heterosis and exploiting it for crop and livestock improvement. In this study, we present the development and first use of the heterotic trait locus (HTL) mapping approach to associate specific intra-locus interactions with an overdominant heterotic mode of inheritance in a diallel population using Sorghum bicolor as the model. This method combines the advantages of ample genetic diversity and the possibility of studying non-additive inheritance. Furthermore, this design enables dissecting the latter to identify specific intra-locus interactions. We identified three HTLs (3.5% of loci tested) with synergistic intra-locus effects on overdominant grain yield heterosis in 2 years of field trials. These loci account for 19.0% of the heterotic variation, including a significant interaction found between two of them. Moreover, analysis of one of these loci (hDPW4.1) in a consecutive F2 population confirmed a significant 21% increase in grain yield of heterozygous vs. homozygous plants in this locus. Notably, two of the three HTLs for grain yield are in synteny with previously reported overdominant quantitative trait loci for grain yield in maize. A mechanism for the reproductive heterosis found in this study is suggested, in which grain yield increase is achieved by releasing the compensatory tradeoffs between biomass and reproductive output, and between seed number and weight. These results highlight the power of analyzing a diverse set of inbreds and their hybrids for unraveling hitherto unknown allelic interactions mediating heterosis.

  7. Study of the Alsys implementation of the Catalogue of Interface Features and Options for the Ada language for 80386 Unix

    Science.gov (United States)

    Gibson, James S.; Barnes, Michael J.; Ostermiller, Daniel L.

    1993-01-01

    A set of programs was written to test the functionality and performance of the Alsys Ada implementation of the Catalogue of Interface Features and Options (CIFO), a set of optional Ada packages for real-time applications. No problems were found with the task id, preemption control, or shared-data packages. Minor problems were found with the dispatching control, dynamic priority, events, non-waiting entry call, semaphore, and scheduling packages. The Alsys implementation is derived mostly from Release 2 of the CIFO standard, but includes some of the features of Release 3 and some modifications unique to Alsys. Performance measurements show that the semaphore and shared-data features are an order-of-magnitude faster than the same mechanisms using an Ada rendezvous. The non-waiting entry call is slightly faster than a standard rendezvous. The existence of errors in the implementation, the incompleteness of the documentation from the published standard impair the usefulness of this implementation. Despite those short-comings, the Alsys CIFO implementation might be of value in the development of real-time applications.

  8. Seven novel mutations at the 5,10-methylenetetrahydrofolate reductase locus

    Energy Technology Data Exchange (ETDEWEB)

    Goyette, P.; Frosst, P.; Rosenblatt, D.S.; Rozen, R. [McGill Univ., Montreal (Canada)

    1994-09-01

    5,10-methylenetetrahydrofolate reductase (MTHFR), a flavoprotein, catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a cofactor for methionine synthase in the methylation of homocysteine to methionine. Severe MTHFR deficiency, which causes homocysteinemia, is an autosomal recessive disorder with variable clinical features; developmental delay, perinatal death, mental retardation and asymptomatic individuals have been observed. A milder deficiency has been reported in patients with cardiovascular disease. We have recently described the isolation of a cDNA for MTHFR and the identification of 2 mutations in patients with severe MTHFR deficiency. We report here the characterization of 7 additional mutations at this locus: 5 missense mutations and 2 splicing mutations. Mutation analysis was performed by SSCP on PCR products generated either from reverse transcription-PCR of patients` total fibroblast RNA or from PCR of patients` genomic DNA. The 5 missense mutations are as follows: 1 Arg to Cys substitution in a hydrophilic segment proposed to be the hinge region that connects the catalytic and regulatory domains, 2 different Arg to Cys substitutions in 2 patients whose enzymatic thermolability is responsive to FAD, 1 Thr to Met substitution affecting an evolutionarily-conserved residue and a Pro to Leu substitution. The 2 splicing mutations affect the 5{prime} splice site and the 3{prime} splice site of 2 introns, respectively. The 5{prime} splice site mutation generates a 57 bp in-frame deletion of the RNA through the utilization of a cryptic 5{prime} splice site within the coding sequence. The identification of 9 mutations at this locus has allowed us to make preliminary correlations between genotype and phenotype and to contribute to a structure:function analysis of the enzyme.

  9. Identification of a shared genetic susceptibility locus for coronary heart disease and periodontitis.

    Directory of Open Access Journals (Sweden)

    Arne S Schaefer

    2009-02-01

    Full Text Available Recent studies indicate a mutual epidemiological relationship between coronary heart disease (CHD and periodontitis. Both diseases are associated with similar risk factors and are characterized by a chronic inflammatory process. In a candidate-gene association study, we identify an association of a genetic susceptibility locus shared by both diseases. We confirm the known association of two neighboring linkage disequilibrium regions on human chromosome 9p21.3 with CHD and show the additional strong association of these loci with the risk of aggressive periodontitis. For the lead SNP of the main associated linkage disequilibrium region, rs1333048, the odds ratio of the autosomal-recessive mode of inheritance is 1.99 (95% confidence interval 1.33-2.94; P = 6.9 x 10(-4 for generalized aggressive periodontitis, and 1.72 (1.06-2.76; P = 2.6 x 10(-2 for localized aggressive periodontitis. The two associated linkage disequilibrium regions map to the sequence of the large antisense noncoding RNA ANRIL, which partly overlaps regulatory and coding sequences of CDKN2A/CDKN2B. A closely located diabetes-associated variant was independent of the CHD and periodontitis risk haplotypes. Our study demonstrates that CHD and periodontitis are genetically related by at least one susceptibility locus, which is possibly involved in ANRIL activity and independent of diabetes associated risk variants within this region. Elucidation of the interplay of ANRIL transcript variants and their involvement in increased susceptibility to the interactive diseases CHD and periodontitis promises new insight into the underlying shared pathogenic mechanisms of these complex common diseases.

  10. 76 FR 3825 - Regulatory Compliance

    Science.gov (United States)

    2011-01-21

    ... Documents#0;#0; ] Memorandum of January 18, 2011 Regulatory Compliance Memorandum for the Heads of Executive... accessible to the public, information concerning their regulatory compliance and enforcement activities, such... enforcement actions). Greater disclosure of regulatory compliance information fosters fair and consistent...

  11. Functional conservation between rodents and chicken of regulatory sequences driving skeletal muscle gene expression in transgenic chickens

    Directory of Open Access Journals (Sweden)

    Taylor Lorna

    2010-02-01

    Full Text Available Abstract Background Regulatory elements that control expression of specific genes during development have been shown in many cases to contain functionally-conserved modules that can be transferred between species and direct gene expression in a comparable developmental pattern. An example of such a module has been identified at the rat myosin light chain (MLC 1/3 locus, which has been well characterised in transgenic mouse studies. This locus contains two promoters encoding two alternatively spliced isoforms of alkali myosin light chain. These promoters are differentially regulated during development through the activity of two enhancer elements. The MLC3 promoter alone has been shown to confer expression of a reporter gene in skeletal and cardiac muscle in transgenic mice and the addition of the downstream MLC enhancer increased expression levels in skeletal muscle. We asked whether this regulatory module, sufficient for striated muscle gene expression in the mouse, would drive expression in similar domains in the chicken. Results We have observed that a conserved downstream MLC enhancer is present in the chicken MLC locus. We found that the rat MLC1/3 regulatory elements were transcriptionally active in chick skeletal muscle primary cultures. We observed that a single copy lentiviral insert containing this regulatory cassette was able to drive expression of a lacZ reporter gene in the fast-fibres of skeletal muscle in chicken in three independent transgenic chicken lines in a pattern similar to the endogenous MLC locus. Reporter gene expression in cardiac muscle tissues was not observed for any of these lines. Conclusions From these results we conclude that skeletal expression from this regulatory module is conserved in a genomic context between rodents and chickens. This transgenic module will be useful in future investigations of muscle development in avian species.

  12. Resultados del tratamiento a pacientes con tríada terrible del codo

    Directory of Open Access Journals (Sweden)

    Héctor Gabriel Díaz Carrillo

    2015-04-01

    Full Text Available La luxación del codo, asociada a la fractura del proceso coronoideo y a la fractura de la cabeza radial, es denominada “tríada terrible del codo”, debido a la complejidad al abordar el tratamiento correcto y lo desalentador de los resultados que se obtienen con el mismo. Se realizó un estudio prospectivo, donde se recogen los resultados postoperatorios, obtenidos en cuatro pacientes con inestabilidad traumática aguda del codo, tratados entre enero de 2012 y mayo de 2013, que acudieron inicialmente al cuerpo de guardia del Hospital General Docente “Dr. Ernesto Guevara de La Serna” y tuvieron un seguimiento medio de ocho meses. El proceder consistió en reparación de la coronoides, del ligamento lateral externo, reparación de la cúpula radial, cupulectomía y colocación de pin endomedular; la técnica operatoria a emplear se definió por los estudios radiográficos realizados y los hallazgos en el transcurso del proceder. Los pacientes, tres hombres y una mujer, tuvieron cinco codos lesionados y un promedio de edad de 34 años. Como resultado del tratamiento la flexión fue normal entre 130-135° en 4 codos y limitada en uno a 110°, la extensión se encontró limitada de 8 a 21° en todos los pacientes, la pronosupinación se mantuvo limitada en todos los casos entre 5 y 22°. La intervención quirúrgica mediante fijación y reparación de los estabilizadores del codo proporcionó a corto plazo una funcionabilidad del codo cercana a la normalidad, los pacientes evolucionaron positivamente. Las complicaciones fueron: reluxación, infección local y aflojamiento de la osteosíntesis

  13. The Spt-Ada-Gcn5 Acetyltransferase (SAGA complex in Aspergillus nidulans.

    Directory of Open Access Journals (Sweden)

    Paraskevi Georgakopoulos

    Full Text Available A mutation screen in Aspergillus nidulans uncovered mutations in the acdX gene that led to altered repression by acetate, but not by glucose. AcdX of A. nidulans is highly conserved with Spt8p of Saccharomyces cerevisiae, and since Spt8p is a component of the Spt-Ada-Gcn5 Acetyltransferase (SAGA complex, the SAGA complex may have a role in acetate repression in A. nidulans. We used a bioinformatic approach to identify genes encoding most members of the SAGA complex in A. nidulans, and a proteomic analysis to confirm that most protein components identified indeed exist as a complex in A. nidulans. No apparent compositional differences were detected in mycelia cultured in acetate compared to glucose medium. The methods used revealed apparent differences between Yeast and A. nidulans in the deubiquitination (DUB module of the complex, which in S. cerevisiae consists of Sgf11p, Sus1p, and Ubp8p. Although a convincing homologue of S. cerevisiae Ubp8p was identified in the A. nidulans genome, there were no apparent homologues for Sus1p and Sgf11p. In addition, when the SAGA complex was purified from A. nidulans, members of the DUB module were not co-purified with the complex, indicating that functional homologues of Sus1p and Sgf11p were not part of the complex. Thus, deubiquitination of H2B-Ub in stress conditions is likely to be regulated differently in A. nidulans compared to S. cerevisiae.

  14. Characteristics of regulatory regimes

    Directory of Open Access Journals (Sweden)

    Noralv Veggeland

    2013-03-01

    Full Text Available The overarching theme of this paper is institutional analysis of basic characteristics of regulatory regimes. The concepts of path dependence and administrative traditions are used throughout. Self-reinforcing or positive feedback processes in political systems represent a basic framework. The empirical point of departure is the EU public procurement directive linked to OECD data concerning use of outsourcing among member states. The question is asked: What has caused the Nordic countries, traditionally not belonging to the Anglo-Saxon market-centred administrative tradition, to be placed so high on the ranking as users of the Market-Type Mechanism (MTM of outsourcing in the public sector vs. in-house provision of services? A thesis is that the reason may be complex, but might be found in an innovative Scandinavian regulatory approach rooted in the Nordic model.

  15. Regulatory functions of microtubules.

    Science.gov (United States)

    Vasiliev, J M; Samoylov, V I

    2013-01-01

    This mini-review summarizes literature and original data about the role of microtubules in interphase animal cells. Recent data have shown that functioning of microtubules is essential for such diverse phenomena as directional cell movements, distribution of organelles in the cytoplasm, and neuronal memory in the central nervous system. It is suggested that microtubules can act as an important regulatory system in eukaryotic cells. Possible mechanisms of these functions are discussed.

  16. Regulatory aspects on nanomedicines.

    Science.gov (United States)

    Sainz, Vanessa; Conniot, João; Matos, Ana I; Peres, Carina; Zupancic, Eva; Moura, Liane; Silva, Liana C; Florindo, Helena F; Gaspar, Rogério S

    2015-12-18

    Nanomedicines have been in the forefront of pharmaceutical research in the last decades, creating new challenges for research community, industry, and regulators. There is a strong demand for the fast development of scientific and technological tools to address unmet medical needs, thus improving human health care and life quality. Tremendous advances in the biomaterials and nanotechnology fields have prompted their use as promising tools to overcome important drawbacks, mostly associated to the non-specific effects of conventional therapeutic approaches. However, the wide range of application of nanomedicines demands a profound knowledge and characterization of these complex products. Their properties need to be extensively understood to avoid unpredicted effects on patients, such as potential immune reactivity. Research policy and alliances have been bringing together scientists, regulators, industry, and, more frequently in recent years, patient representatives and patient advocacy institutions. In order to successfully enhance the development of new technologies, improved strategies for research-based corporate organizations, more integrated research tools dealing with appropriate translational requirements aiming at clinical development, and proactive regulatory policies are essential in the near future. This review focuses on the most important aspects currently recognized as key factors for the regulation of nanomedicines, discussing the efforts under development by industry and regulatory agencies to promote their translation into the market. Regulatory Science aspects driving a faster and safer development of nanomedicines will be a central issue for the next years. Copyright © 2015 Elsevier Inc. All rights reserved.

  17. Quantitative trait locus (QTL) mapping for 100-kernel weight of ...

    African Journals Online (AJOL)

    hope&shola

    2010-12-06

    Dec 6, 2010 ... Abbreviations: KW, 100-kernel weight; CIM, composite interval mapping; CV, coefficient of variation; HNR, high nitrogen regime; LNR, low nitrogen regime; LOD, log10 of odds ratio;. MAS, marker-assisted selection; QTL, quantitative trait locus;. R2, percentage of phenotypic variance explained by QTL; RIL,.

  18. New distal marker closely linked to the fragile X locus

    NARCIS (Netherlands)

    Hulsebos, T. J.; Oostra, B. A.; Broersen, S.; Smits, A.; van Oost, B. A.; Westerveld, A.

    1991-01-01

    We have isolated II-10, a new X-chromosomal probe that identifies a highly informative two-allele TaqI restriction fragment length polymorphism at locus DXS466. Using somatic cell hybrids containing distinct portions of the long arm of the X chromosome, we could localize DXS466 between DXS296 and

  19. New distal marker closely linked to the fragile X locus

    NARCIS (Netherlands)

    T. Hulsebos (Theo); B.A. Oostra (Ben); A. Broersen (Alexander); A. Smits; B.A. van Oost (B.); A. Westerveld (Andries)

    1991-01-01

    textabstractWe have isolated II-10, a new X-chromosomal probe that identifies a highly informative two-allele TaqI restriction fragment length polymorphism at locus DXS466. Using somatic cell hybrids containing distinct portions of the long arm of the X chromosome, we could localize DXS466 between

  20. Male-pattern baldness susceptibility locus at 20p11.

    NARCIS (Netherlands)

    Richards, J.B.; Yuan, X.; Geller, F.; Waterworth, D.; Bataille, V.; Glass, D.; Song, K.; Waeber, G.; Vollenweider, P.; Aben, K.K.H.; Kiemeney, L.A.L.M.; Walters, B.; Soranzo, N.; Thorsteinsdottir, U.; Kong, A.; Rafnar, T.; Deloukas, P.; Sulem, P.; Stefansson, H.; Stefansson, K.; Spector, T.D.; Mooser, V.

    2008-01-01

    We conducted a genome-wide association study for androgenic alopecia in 1,125 men and identified a newly associated locus at chromosome 20p11.22, confirmed in three independent cohorts (n = 1,650; OR = 1.60, P = 1.1 x 10(-14) for rs1160312). The one man in seven who harbors risk alleles at both

  1. Emotional Intelligence, Locus of Control and Conflict Handling Skills ...

    African Journals Online (AJOL)

    This study examined Emotional Intelligence, Locus of control and Conflict Handling Skills as Predictors of non-violent behaviours among University Students in South-Western Nigeria. The population was all the Nigerian University Students in the South-Western Nigerian out of which a sample of 1,000 participants were ...

  2. AUTOMATIC GENERATION OF ROOT LOCUS PLOTS FOR LINEAR ...

    African Journals Online (AJOL)

    Design and analysis of control systems often become difficult due to the complexity of the system model and the design techniques involved. This paper presents the development of a Tools Box in Microsoft Excel for control engineer that uses root locus as a time domain technique for system design and analysis. The Tool ...

  3. Exploring Learner Autonomy: Language Learning Locus of Control in Multilinguals

    Science.gov (United States)

    Peek, Ron

    2016-01-01

    By using data from an online language learning beliefs survey (n?=?841), defining language learning experience in terms of participants' multilingualism, and using a domain-specific language learning locus of control (LLLOC) instrument, this article examines whether more experienced language learners can also be seen as more autonomous language…

  4. Relationships among Impulsiveness, Locus of Control, Sex, and Music Practice

    Science.gov (United States)

    Miksza, Peter

    2006-01-01

    This study is an investigation of relationships among impulsiveness, locus of control, sex, observed practice behaviors, practice effectiveness, and self-reported practice habits in a sample of 40 college brass players. Practice effectiveness was defined by the amount of change in pretest and posttest performance achievement scores over one…

  5. Comparison of Locus of Control with Levels of Creativity.

    Science.gov (United States)

    Kneipp, Karen B.; Gadzella, Bernadette M.

    This study was undertaken to determine whether external locus of control orientation was significantly negatively correlated with levels of creativity. Subjects were 13 male and 13 female undergraduate students enrolled in psychology classes at a southwestern university. Mean age of the subjects was 28.6. Instruments used were Levenson's (1972) I…

  6. Dealing with Malfunction: Locus of Control in Web-Conferencing

    Science.gov (United States)

    Klebl, Michael

    2014-01-01

    This paper considers how students deal with malfunctions that occur during the use of web conferencing systems in learning arrangements. In a survey among participants in online courses that make use of a web-conferencing system (N = 129), the relationship between a preference for internal or external locus of control and the perception of…

  7. Demographic Determinants of Locus of Control among Medical ...

    African Journals Online (AJOL)

    The Levenson Multidimensional Locus of Control Inventory and a Socio - demographic data collection sheet were used to collect data from 262 (183 males and 79 females) students selected through convenience sampling. Data were th analyzed using the 16th version of the SPPS. Percentages, means, t-test and ANOVA ...

  8. Social support, locus of control, and psychological well-being

    NARCIS (Netherlands)

    van der Zee, KI; Buunk, BP; Sanderman, R

    1997-01-01

    Social support seems to be positively related to psychological well-being. Studies have shown that individual differences exist in the ability to mobilize and use sources of support. The current study focused on locus of control as a personality factor that might be related to this ability, In 2

  9. Locus of control and investment in risky assets

    NARCIS (Netherlands)

    Salamanca Acosta, Nicolas; de Grip, A.; Fouarge, Didier; Montizaan, Raymond

    2016-01-01

    We show that household heads with a strong internal economic locus of control are more likely to hold equity and hold a larger share of equity in their investment portfolio. This relation holds when we control for economic preferences and possible confounders such as financial literacy,

  10. Refinement of the locus for non-syndromic sensorineural deafness ...

    Indian Academy of Sciences (India)

    Unknown

    2004-04-05

    Bergstrom et al. 1971). Several X-linked forms of isolated bilateral hearing impairment have been reported and their classification is based on the mode of onset and audiogram data (Gorlin 1995). Genetically, the locus DFN1 had been ...

  11. Response to selection in finite locus models with nonadditive effects

    NARCIS (Netherlands)

    Esfandyari, Hadi; Henryon, Mark; Berg, Peer; Thomasen, Jørn Rind; Bijma, Piter; Sørensen, Anders Christian

    2017-01-01

    Under the finite-locus model in the absence of mutation, the additive genetic variation is expected to decrease when directional selection is acting on a population, according to quantitative-genetic theory. However, some theoretical studies of selection suggest that the level of additive

  12. A multi-locus phylogenetic evaluation of Diaporthe (Phomopsis)

    NARCIS (Netherlands)

    Udayanga, D.; Liu, X.; Crous, P.W.; McKenzie, E.H.C.; Chukeatirote, E.; Hyde, K.D.

    2012-01-01

    The genus Diaporthe (Phomopsis) includes important plant pathogenic fungi with wide host ranges and geographic distributions. In the present study, phylogenetic species recognition in Diaporthe is re-evaluated using a multi-locus phylogeny based on a combined data matrix of rDNA ITS, and partial

  13. Concept -Mapping, Students' Locus of Control and Gender as ...

    African Journals Online (AJOL)

    This study investigated the relative effectiveness of concept mapping and lecture methods on the academic achievement of Nigerian High School Studies in biology using gender and locus of control as intervening variables. This study made use of a 2 x 2 x 2 non-randomised control group, pretest - posttest ...

  14. Locus of control and learning strategies as predictors of academic ...

    African Journals Online (AJOL)

    The aim of the research was to determine the relationships which exist between academic success, learning strategies and locus of control. In order to achieve this aim a small-scale quantitative study, utilising two inventories, was done. The first measuring instrument is the Learning and Study Strategies Inventory, which is ...

  15. automatic generation of root locus plots for linear time invariant

    African Journals Online (AJOL)

    user

    other software package and the ease of using it on the readily available Microsoft Excel environment. Keywords: Asymptotes, Poles, Root Locus, Singularity Point, Zeros. 1. INTRODUCTION. The evolution of Control Engineering practice has propelled the performance of any design system to a reasonable satisfaction which ...

  16. Screening for genomic rearrangements at BRCA1 locus in Iranian ...

    Indian Academy of Sciences (India)

    Home; Journals; Journal of Genetics; Volume 92; Issue 1. Screening for genomic rearrangements at BRCA1 locus in Iranian women with breast cancer using multiplex ligation-dependent probe amplification. Vahid R. Yassaee Babak Emamalizadeh Mir Davood Omrani. Research Note Volume 92 Issue 1 April 2013 pp 131- ...

  17. Inferring relationships between pairs of individuals from locus heterozygosities

    Directory of Open Access Journals (Sweden)

    Spinetti Isabella

    2002-11-01

    Full Text Available Abstract Background The traditional exact method for inferring relationships between individuals from genetic data is not easily applicable in all situations that may be encountered in several fields of applied genetics. This study describes an approach that gives affordable results and is easily applicable; it is based on the probabilities that two individuals share 0, 1 or both alleles at a locus identical by state. Results We show that these probabilities (zi depend on locus heterozygosity (H, and are scarcely affected by variation of the distribution of allele frequencies. This allows us to obtain empirical curves relating zi's to H for a series of common relationships, so that the likelihood ratio of a pair of relationships between any two individuals, given their genotypes at a locus, is a function of a single parameter, H. Application to large samples of mother-child and full-sib pairs shows that the statistical power of this method to infer the correct relationship is not much lower than the exact method. Analysis of a large database of STR data proves that locus heterozygosity does not vary significantly among Caucasian populations, apart from special cases, so that the likelihood ratio of the more common relationships between pairs of individuals may be obtained by looking at tabulated zi values. Conclusions A simple method is provided, which may be used by any scientist with the help of a calculator or a spreadsheet to compute the likelihood ratios of common alternative relationships between pairs of individuals.

  18. Relationship Among Achievement Motivation, Self-Esteem, Locus of ...

    African Journals Online (AJOL)

    The thrust of the study was to examine the relationship among achievement motivation, self-esteem, locus of control and academic performance of university students in a Nigerian University. The purpose was to determine the extent university student\\'s academic performance was influenced by these criterion variables.

  19. Influence of Locus Control on Real and Perceived Relationships ...

    African Journals Online (AJOL)

    They included the Nowicki-Strickland Internal – External Locus of Control Scale for children by Nowicki and Strickland (1973) and Emotional – Social Loneliness Inventory by Vincenzi and Grabosky, (1987). A cross sectional survey design was used while regression analysis and multivariate statistics were used in data ...

  20. Relationship between internet addiction and academic locus of ...

    African Journals Online (AJOL)

    The study identified the various internet activities engaged in by students in a Nigerian University and examined the relationship between internet addiction and their academic locus of control. The sample was made of 250 students selected from a University in Nigeria. An instrument tagged “Questionnaire on Students' ...

  1. Comparison of multi-locus enzyme and protein gel electrophoresis ...

    African Journals Online (AJOL)

    Comparison of multi-locus enzyme and protein gel electrophoresis in the discrimination of five Fusarium species isolated from Egyptian cottons. ... resolution in organizing all isolates in their respective species-specific clusters. A low correlations was detected between geographical origin of isolates and genetic diversity.

  2. Sam Karlin and multi-locus population genetics.

    Science.gov (United States)

    Feldman, Marcus W

    2009-06-01

    Between 1967 and 1982, Sam Karlin made fundamental contributions to many areas of deterministic population genetic theory. This remembrance focuses on his work in multi-locus population genetics, primarily on the interaction between genotypic selection and the rate of recombination.

  3. The Influence of Locus of Control on Student Financial Behavior

    Science.gov (United States)

    Britt, Sonya; Cumbie, Julie A.; Bell, Mary M.

    2013-01-01

    Data on psychological influences of financial behaviors has not been well addressed in student populations, which is concerning given the high levels of general and financial stress experienced by college students. The findings of this study indicate that college students with an external locus of control exhibit the worst financial behaviors.…

  4. 40 CFR 798.5195 - Mouse biochemical specific locus test.

    Science.gov (United States)

    2010-07-01

    ... pattern. Presumed mutants are bred to confirm the genetic nature of the change. (3) Animal selection—(i... SUBSTANCES CONTROL ACT (CONTINUED) HEALTH EFFECTS TESTING GUIDELINES Genetic Toxicity § 798.5195 Mouse...) A biochemical specific locus mutation is a genetic change resulting from a DNA lesion causing...

  5. Gender, Age and Locus of Control as Correlates of Remedial ...

    African Journals Online (AJOL)

    The study sought to explain remedial learners' attitude towards English language using three variables: gender, age and locus of control. Three properly validated instruments were used to collect data on the relevant variables from 385 remedial English learners randomly selected from 5 remedial education centers in ...

  6. Locus of Control and Smokeless Tobacco Use Among Adolescents.

    Science.gov (United States)

    Dignan, Mark; And Others

    1986-01-01

    Surveyed seventh-grade students from two school districts in rural North Carolina to determine the prevalence and correlates of smokeless tobacco use. Of those reporting use of smokeless tobacco, virtually all were male. Locus of control of "occasional" users was significantly more internal than those reporting "regular" use.…

  7. Exploring the relationship between work locus of control and job ...

    African Journals Online (AJOL)

    Therefore, to improve the performance of commercial banks in Nigeria, employer of labour should resharpen recruitment tools in a way that can identify candidates with internal work locus of control for appointment. Management of Commercial Banks in Nigeria should equally organise training programs that can boost ...

  8. Locus of the intensity effect in simple reaction time tasks

    NARCIS (Netherlands)

    Jaśkowski, Piotr; Kurczewska, Marta; Nowik, Agnieszka; van der Lubbe, Robert Henricus Johannes; Verleger, Rolf

    2007-01-01

    Evidence is still inconclusive regarding the locus of the stimulus intensity effect on information processing in reaction tasks. Miller, Ulrich, and Rinkenauer (1999) addressed this question by assessing the intensity effect on stimulus- and response-locked lateralized readiness potentials (LRPs) as

  9. Determination of the yield locus by means of temperature measurement

    NARCIS (Netherlands)

    Banabic, D.; Huetink, Han

    2006-01-01

    The paper presents a theoretical background of the thermo-graphical method of determining the yield locus. The analytical expression of the temperature variation of the specimen deformed in the elastic state is determined starting from the first law of thermodynamics. The experimental method for

  10. (PLWHA): influence of social support, self-esteem, health locus

    African Journals Online (AJOL)

    Coping among people living with HIV/AIDS (PLWHA): influence of social support, self-esteem, health locus of control and gender. ... 73) = 5.59, p.05). It is then concluded that management of HIV/AIDS should ...

  11. Y-Chromosome short tandem repeat, typing technology, locus ...

    African Journals Online (AJOL)

    Y-Chromosome short tandem repeat, typing technology, locus information and allele frequency in different population: A review. ... This review will highlight the importance of the Y- Chromosome as a tool for tracing human evolution and describes some details of Y-chromosomal short tandem repeat (STR) analysis. Among ...

  12. Influence of organisational climate and locus of control on job ...

    African Journals Online (AJOL)

    This study examined the influence of perceived organisational climate and locus of control on job satisfaction and turnover intentions of commercial bank workers in Benin, Edo State, Nigeria. To determine this, a 2X2 ANOVA was used to analyse the data. Results from a field study of 200 employees of 25 commercial banks ...

  13. Influences of peer relations and locus of control on students ...

    African Journals Online (AJOL)

    Effort to checkmate extravagance and maximize gain is the focus of all organizations more in this period of global financial crisis. There is need therefore to checkmate unnecessary financial spending. This study examines the influence of the variables, peer relations and locus of control, on such spending among University ...

  14. 240 INFLUENCES OF PEER RELATIONS AND LOCUS OF ...

    African Journals Online (AJOL)

    therefore to checkmate unnecessary financial spending. This study examines the influence of the variables, peer relations and locus of control, on such spending among University students. Three hundred (144 males and 156 females) participants were used for the study. Their ages ranged between 20-30 years with mean ...

  15. Emotional intelligence and locus of control of adult patients with ...

    African Journals Online (AJOL)

    Background: This article investigates emotional intelligence and locus of control in an adult breast cancer population receiving treatment. Gaining insight into these constructs will contribute to improving breast cancer patients' psychological well-being and to reducing physical vulnerability to disease before and during ...

  16. Health locus of control and internal resilience factors among ...

    African Journals Online (AJOL)

    ... the Multidimensional Health Locus of Control Scale (MHLC) (Wallston et al., 1978:165) and a modified version of the Resilience Scale (Wagnild & Young, 1993:160). Analysis of variance of the loci of control and resilience scores were conducted. Although 78% of the resilience scores were well within the moderate range, ...

  17. Locus of Control and Learning Disabilities: A Review and Discussion.

    Science.gov (United States)

    Dudley-Marling, Curtis C.; And Others

    1982-01-01

    A literature review reveals that learning disabled children are more likely than normal achievers to attribute successes, but not failures, to external factors. The implications of locus of control for the field of learning disabilities are discussed in terms of its relation to academic achievement, learned helplessness, and remediation programs.…

  18. Communication Anxiety, Self-Image, and Locus of Control.

    Science.gov (United States)

    McGary, Lois J.; Parks, Arlie Muller

    A study was conducted (1) to determine the effectiveness of a specially designed one-semester basic speech course on the self-image of college students experiencing extreme communication anxiety, and (2) to discover whether a difference existed between the self-image of students who had an external locus of control and those with an internal locus…

  19. DNA marker mining of ILSTS035 microsatellite locus on ...

    Indian Academy of Sciences (India)

    We describe tests for detecting and locating quantitative trait loci (QTL) for traits in Hanwoo cattle. From results of a permutation test to detect QTL for marbling, we selected the microsatellite locus ILSTS035 on chromosome 6 for further analysis. -means clustering analysis applied to five traits and nine DNA markers in ...

  20. Balancing selection on a regulatory region exhibiting ancient variation that predates human-neandertal divergence.

    Science.gov (United States)

    Gokcumen, Omer; Zhu, Qihui; Mulder, Lubbertus C F; Iskow, Rebecca C; Austermann, Christian; Scharer, Christopher D; Raj, Towfique; Boss, Jeremy M; Sunyaev, Shamil; Price, Alkes; Stranger, Barbara; Simon, Viviana; Lee, Charles

    2013-04-01

    Ancient population structure shaping contemporary genetic variation has been recently appreciated and has important implications regarding our understanding of the structure of modern human genomes. We identified a ∼36-kb DNA segment in the human genome that displays an ancient substructure. The variation at this locus exists primarily as two highly divergent haplogroups. One of these haplogroups (the NE1 haplogroup) aligns with the Neandertal haplotype and contains a 4.6-kb deletion polymorphism in perfect linkage disequilibrium with 12 single nucleotide polymorphisms (SNPs) across diverse populations. The other haplogroup, which does not contain the 4.6-kb deletion, aligns with the chimpanzee haplotype and is likely ancestral. Africans have higher overall pairwise differences with the Neandertal haplotype than Eurasians do for this NE1 locus (pNeandertal admixture contributing to this locus. However, an in-depth assessment of the variation in this region across multiple populations reveals that African NE1 haplotypes, albeit rare, harbor more sequence variation than NE1 haplotypes found in Europeans, indicating an ancient African origin of this haplogroup and refuting recent Neandertal admixture. Population genetic analyses of the SNPs within each of these haplogroups, along with genome-wide comparisons revealed significant FST (p = 0.00003) and positive Tajima's D (p = 0.00285) statistics, pointing to non-neutral evolution of this locus. The NE1 locus harbors no protein-coding genes, but contains transcribed sequences as well as sequences with putative regulatory function based on bioinformatic predictions and in vitro experiments. We postulate that the variation observed at this locus predates Human-Neandertal divergence and is evolving under balancing selection, especially among European populations.

  1. Evolutionary process of a tetranucleotide microsatellite locus in Acipenseriformes.

    Science.gov (United States)

    Shao, Zhao Jun; Rivals, Eric; Zhao, Na; Lek, Sovan; Chang, Jianbo; Berrebi, Patrick

    2011-08-01

    The evolutionary dynamics of the tetra-nucleotide microsatellite locus Spl-106 were investigated at the repeat and flanking sequences in 137 individuals of 15 Acipenseriform species, giving 93 homologous sequences, which were detected in 11 out of 15 species. Twenty-three haplotypes of flanking sequences and three distinct types of repeats, type I, type II and type III, were found within these 93 sequences. The MS-Align hylogenetic method, newly applied to microsatellite sequences, permitted us to understand the repeat and flanking sequence evolution of Spl-106 locus. The flanking region of locus Spl-106 was highly conserved among the species of genera Acipenser, Huso and Scaphirhynchus, which diverged about 150 million years ago (Mya). The rate of flanking sequence divergence at the microsatellite locus Spl-106 in sturgeons is between 0.011% and 0.079% with an average at 0.028% per million years. Sequence alignment and phylogenetic trees produced by MS-Align showed that both the flanking and repeat regions can cluster the alleles of different species into Pacific and Atlantic lineages. Our results show a synchronous evolutionary pattern between the flanking and repeat regions. Moreover, the coexistence of different repeat types in the same species, even in the same individual, is probably due to two duplication events encompassing the locus Spl-106 that occurred during the divergence of Pacific lineage. The first occured before the diversification of Pacific species (121-96 Mya) and led to repeat types I and II. The second occurred more recently, just before the speciation of A. sinensis and A. dabryanus (69-10 Mya), and led to repeat type III. Sequences in the same species with different repeat types probably corresponds to paralogous loci. This study sheds a new light on the evolutionary mechanisms that shape the complex microsatellite loci involving different repeat types.

  2. Achievement motivation and locus of control of black university students

    Directory of Open Access Journals (Sweden)

    Ronel Erwee

    1986-04-01

    Full Text Available The objective of the study was to research the dimensionality of achievement motivation and locus of control in black university students. The Achievement Motivation Questionnaire (Pottas, Erwee, Boshoff & Lessing, 1980 and the Internal-External Locus of Control Scale (Rotter, 1966 were completed by 251 students. Three locus of control factors were extracted by means of principal factor analysis with varimax rotation, viz. Personal control, Political control, and Control over social relationships. The hypothesis that locus of control is a multi-dimensional construct was accepted. No significant sex differences occurred in the total scores obtained on the questionnaire. However, analyses of the subscales indicated that females seem to be more action-orientated, but believe that they can exert less control over political and world events than males. The hypothesis that locus of control and achievement motivation are two separate but interrelated constructs was supported. OpsommingDie doelwit van die studie was om die dimensionaliteit van swart studente se prestasiemotivering en lokus-van-kontrole na te vors. Die Prestasie-motiveringsvraelys (Pottas, Erwee, Boshoff en Lessing, 1980 en die Interne- Eksterne Lokus van Kontroleskaal (Rotter, 1966 is deur 251 studente voltooi. Drie lokus-van-kontrolefaktore, naamlik Persoonlike kontrole, Politieke kontrole en Kontrole oor interpersoonlike verhoudings, is deur middel van 'n hooffaktorontleding (met varimax-rotasie onttrek. Die hipotese dat lokus-van- kontrole 'n multidimensionele konstruk is, is aanvaar. Geen beduidende geslagsverskille in die totaaltellings op die meetinstrumente het voorgekom nie. Analises van die subskale het egter aangetoon dat die vroue hulself as meer aksie-georienteerd beskou het, maar oortuig was dat hulle nie veel beheer oor politieke en wereldgebeure het nie. Die hipotese dat prestasiemotivering en lokus-van-kontrole twee afsonderlike maar verwante konstrukte is, is aanvaar.

  3. Proceedings of the Annual National Conference on Ada (Trade Name) Technology (4th) Held in Atlanta, Georgia on 19-20 March 1986.

    Science.gov (United States)

    1986-01-01

    ever after. of Ada language. Nevertheless, the description of concepts in an Ada-like This fairy tale is fanciful perhaps, fashion still clarifies the...Introduction mathematical problem in a high-order lan- guage. This is a dilemma that has been An Educational Fairy Tale growing for the last 20 years. In...can be examined using the inte-rupt handlers were added, monitor on the tracker. For the execution progress variables use values such as hexa- decimal

  4. Ada (Trade Name) Compiler Validation Summary Report: ALSYS Ltd AlsyCOMP - 007, V1.0 Host: HP 1000 A900 Target: Same as Host.

    Science.gov (United States)

    1987-06-18

    implements legal language constructs and that it identifies and rejects illegal language constructs. The testing also identifies behaviour that is...that the implementation-dependent behaviour is allowed by the Ada Standard Testing of this compiler was conducted by NCC under the direction of the...accurate and complete, or that the subject compiler has no nonconformities to the Ada Standard other than those presented. Copies of this report are

  5. Novel Crohn disease locus identified by genome-wide association maps to a gene desert on 5p13.1 and modulates expression of PTGER4.

    Directory of Open Access Journals (Sweden)

    Cécile Libioulle

    2007-04-01

    Full Text Available To identify novel susceptibility loci for Crohn disease (CD, we undertook a genome-wide association study with more than 300,000 SNPs characterized in 547 patients and 928 controls. We found three chromosome regions that provided evidence of disease association with p-values between 10(-6 and 10(-9. Two of these (IL23R on Chromosome 1 and CARD15 on Chromosome 16 correspond to genes previously reported to be associated with CD. In addition, a 250-kb region of Chromosome 5p13.1 was found to contain multiple markers with strongly suggestive evidence of disease association (including four markers with p < 10(-7. We replicated the results for 5p13.1 by studying 1,266 additional CD patients, 559 additional controls, and 428 trios. Significant evidence of association (p < 4 x 10(-4 was found in case/control comparisons with the replication data, while associated alleles were over-transmitted to affected offspring (p < 0.05, thus confirming that the 5p13.1 locus contributes to CD susceptibility. The CD-associated 250-kb region was saturated with 111 SNP markers. Haplotype analysis supports a complex locus architecture with multiple variants contributing to disease susceptibility. The novel 5p13.1 CD locus is contained within a 1.25-Mb gene desert. We present evidence that disease-associated alleles correlate with quantitative expression levels of the prostaglandin receptor EP4, PTGER4, the gene that resides closest to the associated region. Our results identify a major new susceptibility locus for CD, and suggest that genetic variants associated with disease risk at this locus could modulate cis-acting regulatory elements of PTGER4.

  6. Reframing Student Affairs Leadership: An Analysis of Organizational Frames of Reference and Locus of Control

    Science.gov (United States)

    Tull, Ashley; Freeman, Jerrid P.

    2011-01-01

    Examined in this study were the identified frames of reference and locus of control used by 478 student affairs administrators. Administrator responses were examined to identify frames of reference most commonly used and their preference order. Locus of control most commonly used and the relationship between frames of reference and locus of…

  7. Locus of Control in Offenders and Alleged Offenders with Learning Disabilities

    Science.gov (United States)

    Goodman, Wendy; Leggett, Janice; Garrett, Tanya

    2007-01-01

    Locus of control can be a useful measure of treatment outcome in offenders from the general population. However, there is little information regarding locus of control and offenders with learning disabilities. Existing measures of locus of control use complex language and abstract ideas that may not be accessible to individuals in this group. A…

  8. On the Relation of Locus of Control and L2 Reading and Writing Achievement

    Science.gov (United States)

    Ghonsooly, Behzad; Shirvan, Majid Elahi

    2011-01-01

    Locus of control, a psychological construct, has been the focus of attention in recent decades. Psychologists have discussed the effect of locus of control on achieving life goals in social/psychological interactions. While learning a foreign language involves both social interactions and psychological processes, the role and relation of locus of…

  9. On the Locus Formed by the Maximum Heights of Projectile Motion with Air Resistance

    Science.gov (United States)

    Hernandez-Saldana, H.

    2010-01-01

    We present an analysis on the locus formed by the set of maxima of the trajectories of a projectile launched in a medium with linear drag. Such a place, the locus of apexes, is written in terms of the Lambert "W" function in polar coordinates, confirming the special role played by this function in the problem. To characterize the locus, a study of…

  10. Research Paper Predicting HIV risk using a locus of control-based ...

    African Journals Online (AJOL)

    The study performed correlational and linear regression analyses using statistical software SAS to establish the relationship between locus of control-based factors and HIV risk. Results: The results showed significant correlations between locus of control-based variables and HIV risk. The locus of control-based model ...

  11. DMPD: The Lps locus: genetic regulation of host responses to bacteriallipopolysaccharide. [Dynamic Macrophage Pathway CSML Database

    Lifescience Database Archive (English)

    Full Text Available 10669111 The Lps locus: genetic regulation of host responses to bacteriallipopolysa...ccharide. Qureshi ST, Gros P, Malo D. Inflamm Res. 1999 Dec;48(12):613-20. (.png) (.svg) (.html) (.csml) Show The Lps locus: genetic... regulation of host responses to bacteriallipopolysaccharide. PubmedID 10669111 Title The Lps locus: genetic

  12. Selective constraints in experimentally defined primate regulatory regions.

    Directory of Open Access Journals (Sweden)

    Daniel J Gaffney

    2008-08-01

    Full Text Available Changes in gene regulation may be important in evolution. However, the evolutionary properties of regulatory mutations are currently poorly understood. This is partly the result of an incomplete annotation of functional regulatory DNA in many species. For example, transcription factor binding sites (TFBSs, a major component of eukaryotic regulatory architecture, are typically short, degenerate, and therefore difficult to differentiate from randomly occurring, nonfunctional sequences. Furthermore, although sites such as TFBSs can be computationally predicted using evolutionary conservation as a criterion, estimates of the true level of selective constraint (defined as the fraction of strongly deleterious mutations occurring at a locus in regulatory regions will, by definition, be upwardly biased in datasets that are a priori evolutionarily conserved. Here we investigate the fitness effects of regulatory mutations using two complementary datasets of human TFBSs that are likely to be relatively free of ascertainment bias with respect to evolutionary conservation but, importantly, are supported by experimental data. The first is a collection of almost >2,100 human TFBSs drawn from the literature in the TRANSFAC database, and the second is derived from several recent high-throughput chromatin immunoprecipitation coupled with genomic microarray (ChIP-chip analyses. We also define a set of putative cis-regulatory modules (pCRMs by spatially clustering multiple TFBSs that regulate the same gene. We find that a relatively high proportion ( approximately 37% of mutations at TFBSs are strongly deleterious, similar to that at a 2-fold degenerate protein-coding site. However, constraint is significantly reduced in human and chimpanzee pCRMS and ChIP-chip sequences, relative to macaques. We estimate that the fraction of regulatory mutations that have been driven to fixation by positive selection in humans is not significantly different from zero. We also find

  13. Ada Compiler Validation Summary Report. Certificate Number: 891019W1. 10178, Hewlett Packard Company HP 9000 Series 800 Ada Compiler, Version 4.35 HP 9000 Series 800 Model 850. Completion of On-Site Testing: 19 October 1989

    Science.gov (United States)

    1989-10-19

    34 HPC * HP Pascal " HP FORTRAN 77 for HP 9000 Series 800 computers Compiler products from vendors other than Hewlett-Packard may not conform to the...maximum number of elements needed U-SIZE: constant := U size; -- Subsitute U’SIZE here -- The constant U SIZE should also be: -- 1. a multiple of two... product does not support the association of an HP-UX signal such as SIGINT with an Ada procedure or a task entry. The signal must be handled inside an

  14. Meeting Regulatory Needs.

    Science.gov (United States)

    Weber, Michael Fred

    2017-02-01

    The world is experiencing change at an unprecedented pace, as reflected in social, cultural, economic, political, and technological advances around the globe. Regulatory agencies, like the U.S. Nuclear Regulatory Commission (NRC), must also transform in response to and in preparation for these changes. In 2014, the NRC staff commenced Project Aim 2020 to transform the agency by enhancing efficiency, agility, and responsiveness, while accomplishing NRC's safety and security mission. Following Commission review and approval in 2015, the NRC began implementing the approved strategies, including strategic workforce planning to provide confidence that NRC will have employees with the right skills and talents at the right time to accomplish the agency's mission. Based on the work conducted so far, ensuring an adequate pipeline of radiation protection professionals is a significant need that NRC shares with states and other government agencies, private industry, academia, as well as international counterparts. NRC is working to ensure that sufficient radiation protection professionals will be available to fulfill its safety and security mission and leverage the work of the National Council on Radiation Protection and Measurements, the Conference of Radiation Control Program Directors, the Health Physics Society, the Organization of Agreement States, the International Atomic Energy Agency, the Nuclear Energy Agency, and others.

  15. An investigation on the mediating role of coping strategies on locus of control-- wellbeing relationship.

    Science.gov (United States)

    Thiruchelvi, Arunachalam; Supriya, Mangatvadakkeveetil V

    2012-03-01

    The relationship among coping strategies, locus of control, and workplace wellbeing is examined. The model hypothesizes that coping strategies mediate the relationship between locus of control and work place well being. To test the model, data was collected from 154 software professionals using separate tools to assess coping strategies, locus of control and work place wellbeing. Model fit for the collected data was examined using structural equation modeling technique with the help of AMOS. Results support the view that coping strategies mediate the relationship between locus of control and work place wellbeing. While the path between locus of control and wellbeing is significant, the path between coping distraction and wellbeing is not significant.

  16. Regulatory elements in molecular networks.

    Science.gov (United States)

    Doane, Ashley S; Elemento, Olivier

    2017-05-01

    Regulatory elements determine the connectivity of molecular networks and mediate a variety of regulatory processes ranging from DNA looping to transcriptional, posttranscriptional, and posttranslational regulation. This review highlights our current understanding of the different types of regulatory elements found in molecular networks with a focus on DNA regulatory elements. We highlight technical advances and current challenges for the mapping of regulatory elements at the genome-wide scale, and describe new computational methods to uncover these elements via reconstructing regulatory networks from large genomic datasets. WIREs Syst Biol Med 2017, 9:e1374. doi: 10.1002/wsbm.1374 For further resources related to this article, please visit the WIREs website. © 2017 Wiley Periodicals, Inc.

  17. Identification of a functional NF-kappa B binding site in the murine T cell receptor beta 2 locus.

    Science.gov (United States)

    Jamieson, C; Mauxion, F; Sen, R

    1989-11-01

    We have identified a sequence in the TCR beta 2 locus that is homologous to the kappa B site in the Ig kappa light chain enhancer. This element, TCR beta-B, is located in the vicinity of previously identified T cell-specific DNase1 hypersensitive sites. Transfection analysis shows that a 60-bp fragment encompassing this site is preferentially active in T cells stimulated with phorbol esters or the HTLV-1 tax gene product compared with a B cell line that constitutively expresses NF-kappa B. Our results provide the first evidence for transcriptional regulatory sequences residing within the J beta 2-C beta 2 intron and suggest the possible involvement of these sequences in modulation of TCR beta gene expression upon cellular activation.

  18. Academic anxiety, locus of control, and achievement in medical school.

    Science.gov (United States)

    Grover, P L; Smith, D U

    1981-09-01

    Programs designed to assist medical students in academic difficulty typically fail to consider the importance of such factors as academic anxiety and the individual's mechanisms for coping with stress. The authors have addressed this issue by examining relationships among prior achievement, academic anxiety, locus of control, and performance in the first year of medical school. Academic anxiety not only was found to be significantly related to first year performance, but also, when combined with a measure of prior achievement, resulted in a significant increase in prediction. Additional evidence is presented which suggests that the relationship between academic anxiety and achievement may be curvilinear. Locus of control was found to correlate significantly with academic anxiety and tended to shift in a direction of greater externality during the first year of medical school. Findings are discussed within the framework of existing psychological research, and implications are presented for medical admissions, curricula, and counseling.

  19. The validity of locus of control dimensions for Chicano populations.

    Science.gov (United States)

    Garza, R T; Widlak, F W

    1977-12-01

    The multidimensional locus of control literature supported the tenability of five factorial dimensions: a) luck/fate, b) leadership/success, c) academics, d) politics, and e) respect. Contending that the contradictory locus of control findings involving Chicano populations may be due to methodological inadequacies, the purpose of the present study was to empirically determine the appropriateness of the five categories for comparing Chicano and Anglo populations. This was done by factor analyzing the responses of 203 Anglo and 244 Chicano undergraduates to Rotter's (1966) 1-E scale separately, and then comparing the corresponding factor pairs by using Cliff's (1966) congruence procedure. The luck/fate and leadership/success factors show substantial invariance across the two samples, whereas the cultural equivalence of the remaining three factors is somewhat questionable. The findings are discussed in relation to current knowledge of cross-cultural differences between Anglo and Chicano populations.

  20. Locus Solus: The New York School Poets’ Missing Manifesto

    Directory of Open Access Journals (Sweden)

    Evelyn Austin

    2014-07-01

    Full Text Available Although the New York School of poetry is at its core a literary coterie, critics have been hesitant to consider the New York School an organized group. An exploration of Locus Solus, a literary journal edited by John Ashbery, Kenneth Koch, Frank O’Hara, Harry Mathews, and James Schuyler, however, reveals that the poets were most definitely concerned with presenting themselves as a joint force in American poetry. Through close reading and archival research, I untangle the poets’ instrumentalization of Locus Solus as an elaborate manifesto, exposing how the first three volumes were used to present the New York School poets and poetics, trace a poetic lineage, and put forward a succeeding generation.

  1. Formulação de um indicador de acessibilidade das calçadas e travessias

    Directory of Open Access Journals (Sweden)

    Celso Luiz Guimarães Keppe Junior

    2008-12-01

    Full Text Available O presente trabalho visa definir uma forma fácil e prática de avaliar-se o nível de serviço dos espaços públicos destinados às pessoas com deficiência física (calçadas e travessias de ruas pela determinação de um índice que considere os parâmetros de maior importância sob o ponto de vista dos usuários de cadeira de rodas. O índice é definido com a identificação e a ordenação de variáveis de caracterização física e ambiental das calçadas relacionadas aos aspectos de qualidade de conforto, segurança e condições do ambiente. A ponderação das variáveis de caracterização física e ambiental das calçadas (grau de importância é realizada por análise da percepção dos usuários de cadeira de rodas, definindo-se, dessa forma, o Índice de Acessibilidade das Calçadas e Travessias - IACT, e verificando sua funcionalidade por auditoria realizada com auxílio, também, de usuários de cadeira de rodas selecionados para realizar testes em dois locais da cidade de São Carlos. Munidos dessa ferramenta de avaliação, os órgãos de gestão viária podem avaliar a qualidade dos espaços públicos em uma rota total ou em trechos específicos dos deslocamentos imprescindíveis para a real participação da pessoa com dificuldade de locomoção na sociedade.

  2. Subjetividad imaginada : Subjetividad y otredad en el personaje de Ada en Hasta siempre, mujercitas de Marcela Serrano

    OpenAIRE

    Lorentzson, Kim

    2016-01-01

    Abstracto: Mediante la teoría feminista El Segundo Sexo (1949), de la escritora y filósofa francesa Simone de Beauvoir, se analiza la novela Hasta Siempre, Mujercitas (2004) de la escritora chilena Marcela Serrano. El análisis se enfoca en la otredad y la subjetividad en el personaje de Ada, para investigar si es un personaje que actúa como un sujeto libre e independiente o si cae víctima bajo las normas e ideales patriarcales. Palabras claves: Marcela Serrano, Simone de Beauvoir, otredad, tr...

  3. Analysis of the ABCA4 genomic locus in Stargardt disease.

    Science.gov (United States)

    Zernant, Jana; Xie, Yajing Angela; Ayuso, Carmen; Riveiro-Alvarez, Rosa; Lopez-Martinez, Miguel-Angel; Simonelli, Francesca; Testa, Francesco; Gorin, Michael B; Strom, Samuel P; Bertelsen, Mette; Rosenberg, Thomas; Boone, Philip M; Yuan, Bo; Ayyagari, Radha; Nagy, Peter L; Tsang, Stephen H; Gouras, Peter; Collison, Frederick T; Lupski, James R; Fishman, Gerald A; Allikmets, Rando

    2014-12-20

    Autosomal recessive Stargardt disease (STGD1, MIM 248200) is caused by mutations in the ABCA4 gene. Complete sequencing of ABCA4 in STGD patients identifies compound heterozygous or homozygous disease-associated alleles in 65-70% of patients and only one mutation in 15-20% of patients. This study was designed to find the missing disease-causing ABCA4 variation by a combination of next-generation sequencing (NGS), array-Comparative Genome Hybridization (aCGH) screening, familial segregation and in silico analyses. The entire 140 kb ABCA4 genomic locus was sequenced in 114 STGD patients with one known ABCA4 exonic mutation revealing, on average, 200 intronic variants per sample. Filtering of these data resulted in 141 candidates for new mutations. Two variants were detected in four samples, two in three samples, and 20 variants in two samples, the remaining 117 new variants were detected only once. Multimodal analysis suggested 12 new likely pathogenic intronic ABCA4 variants, some of which were specific to (isolated) ethnic groups. No copy number variation (large deletions and insertions) was detected in any patient suggesting that it is a very rare event in the ABCA4 locus. Many variants were excluded since they were not conserved in non-human primates, were frequent in African populations and, therefore, represented ancestral, and not disease-associated, variants. The sequence variability in the ABCA4 locus is extensive and the non-coding sequences do not harbor frequent mutations in STGD patients of European-American descent. Defining disease-associated alleles in the ABCA4 locus requires exceptionally well characterized large cohorts and extensive analyses by a combination of various approaches. © The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.

  4. An Analysis of Leader Locus of Control and Influence Behaviors.

    Science.gov (United States)

    1983-05-01

    Social desirability response .j• bias: Three alternative models . Academy of Management Journal, 1983, 26. Graen, C., & Schiemann, W. Leader -member...among managers . Organizational Behavior and Human Performance, 1973, 1 184-200. Durand, D.E., & Nord, W.R. Perceived leader behavior as a function of...AD-A129 100 A N A NALYSIS OF LEAQER LOCUS OF CONTROL AND INFLUENCE BEHAVIORS U) NEBRASKA UNIV LINCOLN DEPT OF MANAGEMENT UNLSIID A L JOHNSON ET AL

  5. Locus-specific view of flax domestication history

    OpenAIRE

    Fu, Yong-Bi; Diederichsen, Axel; Allaby, Robin G.

    2012-01-01

    Crop domestication has been inferred genetically from neutral markers and increasingly from specific domestication-associated loci. However, some crops are utilized for multiple purposes that may or may not be reflected in a single domestication-associated locus. One such example is cultivated flax (Linum usitatissimum L.), the earliest oil and fiber crop, for which domestication history remains poorly understood. Oil composition of cultivated flax and pale flax (L. bienne Mill.) indicates th...

  6. The Effects of Locus of Control and Task Difficulty on Procrastination.

    Science.gov (United States)

    Janssen, Tracy; Carton, John S

    1999-12-01

    The authors investigated the effects of locus of control expectancies and task difficulty on procrastination. Forty-two college students were administered an academic locus of control scale and a task that was similar to a typical college homework assignment. The students were randomly assigned to 1 of 2 task difficulty levels. Although none of the results involving task difficulty was significant, several results involving locus of control were significant. Specifically, analyses revealed that students with internal locus of control expectancies tended to begin working on the assignment sooner than students with external locus of control expectancies. In addition, students with internal locus of control completed and returned the assignment sooner than students with external locus of control. The results are discussed within the context of J. B. Rotter's (1966, 1975, 1982) social learning theory.

  7. The locus standi of private applicants before the Court of Justice of the European Union after Lisbon treaty

    Directory of Open Access Journals (Sweden)

    Ćirković Gordana

    2011-01-01

    Full Text Available The action for annulment is effective remedy for private applicants in protection of their rights. Treaty of the European Community in Article 230 (4 imposed limits on the standing of individuals as it required the applicant to be directly and individually concerned by the contested measure. This requirement, especially in case of individual concern, was very difficult to meet. The Court of Justice had developed over time very restrictive interpretation of the rules for standing of individuals. There were a lot of attempts to change the Court's interpretation of the locus standi of non-privileged applicants, like the ones in cases UPA and Jégo-Quéré, but with no success. It has also been discussed why the Court does not want to change its interpretation. Among many arguments one is especially often invoked and serves to justify Court's unwillingness to relax the conditions for standing. This is the reluctance to add to the Court's already heavy workload. Finally, the reform has come. The Lisbon Treaty makes some modifications under Article 263 (4 TFEU. Private parties are allowed to contest a regulatory act which is of direct concern to them and does not entail implementing measures. It is clear that the new locus standi relies heavily on the distinction between legislative and regulatory acts. Private applicants have been expecting more from the Lisbon Treaty. They still hope that the Court of Justice of the European Union is going to make new changes in the future. After all, the European judges are those who are familiar with law and with the needs of the legal system. Therefore, they are competent to seek the ways which comply with the requirements for an efficient and fair system of judicial protection.

  8. Population genetics of the HRAS1 minisatellite locus

    Energy Technology Data Exchange (ETDEWEB)

    Devlin, B.; Risch, N. (Yale Univ., New Haven, CT (United States)); Krontiris, T. (Tufts Univ., Boston, MA (United States) New England Medical Center Hospital, Boston, MA (United States))

    1993-12-01

    Several years ago it was reported that rare HRAS1 VNTR alleles occurred more frequently in US Caucasian cancer patients than in unaffected controls. Such an association, in theory, could be caused by undetected population heterogeneity. Also, in a study clearly relevant to this issue, it was recently reported that significant deviations from Hardy-Weinberg equilibrium exist at this locus in a sample of US Caucasians. These considerations motivate population genetic analysis of the HRAS1 locus. From published studies of the HRAS1 VNTR locus, which classified alleles into types, the authors found only small differences in the allele frequency distributions of samples from various European nations, although there were larger differences among ethnic groups (African American, Caucasian, and Oriental). In an analysis of variation of rare-allele frequencies among samples from four European nations, most of the variance was attributable to molecular methodology, and very little of the variance was accounted for by nationality. In addition, the authors showed that mixture of European subpopulations should result in only minor deviations from expected genotype proportions in a Caucasian database and demonstrated that there was no significant deviation from Hardy-Weinberg equilibrium in the HRAS1 data. 35 refs., 4 tabs.

  9. Transvection at the vestigial locus of Drosophila melanogaster.

    Science.gov (United States)

    Coulthard, Alistair B; Nolan, Nadia; Bell, John B; Hilliker, Arthur J

    2005-08-01

    Transvection is a phenomenon wherein gene expression is effected by the interaction of alleles in trans and often results in partial complementation between mutant alleles. Transvection is dependent upon somatic pairing between homologous chromosome regions and is a form of interallelic complementation that does not occur at the polypeptide level. In this study we demonstrated that transvection could occur at the vestigial (vg) locus by revealing that partial complementation between two vg mutant alleles could be disrupted by changing the genomic location of the alleles through chromosome rearrangement. If chromosome rearrangements affect transvection by disrupting somatic pairing, then combining chromosome rearrangements that restore somatic pairing should restore transvection. We were able to restore partial complementation in numerous rearrangement trans-heterozygotes, thus providing substantial evidence that the observed complementation at vg results from a transvection effect. Cytological analyses revealed this transvection effect to have a large proximal critical region, a feature common to other transvection effects. In the Drosophila interphase nucleus, paired chromosome arms are separated into distinct, nonoverlapping domains. We propose that if the relative position of each arm in the nucleus is determined by the centromere as a relic of chromosome positions after the last mitotic division, then a locus will be displaced to a different territory of the interphase nucleus relative to its nonrearranged homolog by any rearrangement that links that locus to a different centromere. This physical displacement in the nucleus hinders transvection by disrupting the somatic pairing of homologous chromosomes and gives rise to proximal critical regions.

  10. Relationship between nursing students' epistemological beliefs and locus of control.

    Science.gov (United States)

    Yilmaz, Aylin; Kaya, Hülya

    2010-10-01

    The aim of this study was to determine the relationship between nursing students' epistemologic beliefs and locus of control, and the research was conducted at Istanbul University Florence Nightingale School of Nursing with 350 nursing students. Data were collected using the Turkish version of the Epistemological beliefs questionnaire and Rotter's Internal-External Locus of Control Scale. In the data analysis number, percentage, mean, correlation analysis, one-way analysis of variance and Tukey HSD test were used. The findings as whole indicated that nursing students' epistemological beliefs that "The Belief of Learning Depends on Effort (Effort)" showed a greater degree of development than their beliefs about the two other dimensions as named "The Belief of Learning Depends on Ability (Ability)" and "The Belief That There is Only One Unchanging Truth (Unchanging Truth)" in this study, while their belief that there is Unchanging Truth was not developed when compared to the other two. There was a positive correlation between nursing students locus of control and Effort and Ability dimensions, but a significant correlation was not found with Unchanging Truth dimension. This researcher suggests that research should be carried out to determine nursing students' epistemological beliefs and the factors influencing them in an environment to promote the development of these beliefs, and thus the research can be used to learn about the development of the epistemological beliefs. Copyright © 2010 Elsevier Ltd. All rights reserved.

  11. 78 FR 62417 - Regulatory Capital Rules: Regulatory Capital, Implementation of Basel III, Capital Adequacy...

    Science.gov (United States)

    2013-10-22

    ... Part 324 RIN 3064-AD95 Regulatory Capital Rules: Regulatory Capital, Implementation of Basel III... Capital Rules: Regulatory Capital, Implementation of Basel III, Capital Adequacy, Transition Provisions...

  12. Regulatory mark; Marco regulatorio

    Energy Technology Data Exchange (ETDEWEB)

    NONE

    2009-10-15

    This chapter is based on a work performed in distinct phases. The first phase consisted in of the analysis regulatory legislation existent in Brazil for the sugar-alcohol sector since the beginning of the X X century. This analysis allowed the identification of non existent points and legal devices related to the studied aspects, and that were considered as problematic for the sector expansion. In the second phase, related treaties and international agreements was studied and possible obstacles for the brazilian bio ethanol exportation for the international market. Initiatives were examined at European Union, United States of America, Caribbean and countries of the sub-Saharan Africa. In this phase, policies were identified related to the incentives and adoption of use of bio fuels added to the gasoline in countries or group of countries considered as key for the consolidation of bio ethanol as a world commodity.

  13. Evidence for genetic heterogeneity in tuberous sclerosis: One locus on chromosome 9 and at least one locus elsewhere

    Energy Technology Data Exchange (ETDEWEB)

    Northrup, H.; Rodriguez, E. Jr. (Univ. of Texas Medical School, Houston, TX (United States)); Herman, G.E.; Lewis, R.A. (Baylor College of Medicine, Houston, TX (United States)); Kwiatkowski, D.J. (Brigham and Womens' s Hospital, Boston, MA (United States)); Roach, E.S. (Univ. of Texas Southerwestern Medical School, Dallas, TX (United States)); Dobyns, W.B. (Riley Hospital, Indianapolis, IN (United States)); Daiger, S.P.; Blanton, S.H. (Univ. of Texas Health Science Center, Houston, TX (United States))

    1992-10-01

    Linkage of tuberous sclerosis complex (TSC), an autosomal dominant disorder, to markers on chromosome 9 was reported first in 1987. This assignment was confirmed by an international collaborative study that suggested more than one locus may be responsible for the phenotype. The authors studied 14 multigenerational TSC families (13 previously unreported) with markers for nine loci in the linked region of chromosome 9q32-q34. Results confirm the previous reports that the genetic locus in one-third to one-half of families maps to chromosome 9. Comparison of clinical findings in the chromosome 9-linked families with those in the chromosome 9-unlinked families reveals only a higher incidence of ungual fibromata in the chromosome 9-linked families. 38 refs., 6 figs., 4 tabs.

  14. Regulatory considerations for biosimilars

    Directory of Open Access Journals (Sweden)

    Ranjani Nellore

    2010-01-01

    Full Text Available Currently there is considerable interest in the legislative debate around generic biological drugs or "biosimilars" in the EU and US due to the large, lucrative market that it offers to the industry. While some countries have issued a few regulatory guidelines as well as product specific requirements, there is no general consensus as to a single, simple mechanism similar to the bioequivalence determination that leads to approval of generic small molecules all over the world. The inherent complex nature of the molecules, along with complicated manufacturing and analytical techniques to characterize them make it difficult to rely on a single human pharmacokinetic study for assurance of safety and efficacy. In general, the concept of comparability has been used for evaluation of the currently approved "similar" biological where a step by step assessment on the quality, preclinical and clinical aspects is made. In India, the focus is primarily on the availability and affordability of life-saving drugs. In this context every product needs to be evaluated on its own merit irrespective of the innovator brand. The formation of the National Biotechnology Regulatory Authority may provide a step in the right direction for regulation of these complex molecules. However, in order to have an efficient machinery for initial approval and ongoing oversight with a country-specific focus, cooperation with international authorities for granting approvals and continuous risk-benefit review is essential. Several steps are still needed for India to be perceived as a country that leads the world in providing quality biological products.

  15. Locus de Controle e escolha do método anticoncepcional Locus de Control y método anticonceptivo elegido Locus of Control and choice of contraceptive method

    Directory of Open Access Journals (Sweden)

    Aline Salheb Alves

    2007-06-01

    Full Text Available Objetivou-se avaliar a relação entre o Locus de Controle e o tipo de método contraceptivo escolhido. Foi utilizada a Escala Multidimensional de Locus de Controle de Levenson e entrevistadas 191 mulheres. As usuárias de preservativo masculino apresentaram maior Internalidade do que as usuárias de injetável mensal. Quanto ao locus Externalidade Outros Poderosos, as usuárias de implante apresentavam menor externalidade do que as usuárias de preservativo masculino, laqueadura, injetável trimestral e DIU. Considerando-se o locus Externalidade Acaso, as usuárias de implante apresentaram menores escores do que as mulheres que optaram pela laqueadura, injetável trimestral e DIU. Observou-se ainda, menor Externalidade Acaso entre as usuárias de injetável mensal em relação às mulheres que fizeram opção pelo injetável trimestral.El objetivo es validar la relación entre el Locus de Control y el tipo de método anticonceptivo elegido. Fue usada la Escala Multidimensional de Locus de Control de Levenson. Fueron entrevistadas 191 mujeres. Las usuarias de condón masculino presentaron Internalidad más grande que las usuarias de inyectable mensual. Considerado el Locus Externalidad - Otro poderoso, las usuarias de implante presentaron menor externalidad de que las usuarias de condón masculino, laqueadura, inyectable trimestral y DIU. Considerado el Locus Externalidad - Quizá, las usuarias del implante presentaron menores resultados que las mujeres que eligieron por la laqueadura, inyectable trimestral y DIU. Se observo que las mujeres usuarias de inyectable mensual presentaron menor Externalidad - Quizá que las mujeres usuarias de inyectable trimestral.The purpose was to assess the relationship between locus of control and the contraceptive method chosen. It was used the Levenson's Multidimensional Locus of Control Scale and 191 women was interviewed. Users of male condoms presented greater Internality than the monthly contraceptive

  16. DOMINAÇÃO E REPRESSÃO DA SOCIEDADE INDUSTRIAL AVANÇADA EM HOMEM UNIDIMENSIONAL DE HERBERT MARCUSE

    Directory of Open Access Journals (Sweden)

    Ramom Gomes da Silva

    2017-08-01

    Full Text Available Este trabalho apresenta uma reflexão acerca dos instrumentos de dominação e repressão da sociedade industrial avançada. A partir da leitura da primeira parte do livro Ideologia da sociedade industrial: O homem unidimensional, Herbert Marcuse analisa a sociedade industrial avançada e as tendências do capitalismo tardio expondo as novas formas de controle e dominação dos indivíduos na contemporaneidade. Os meios de dominação do capitalismo avançado têm-se mostrado mais eficientes e eficazes do que antigos regimes baseados na violência explícita, isto é, sem uso de um terror aberto, tem o domínio das esferas da existência humana, sejam elas públicas ou privadas. Esses mecanismos de controles proporcionaram a integração entre o pensamento e o comportamento dos indivíduos, de tal modo que o sujeito sente-se livre em situação de não liberdade, situação em que  necessidades impostas são aceitas e ainda repassadas às gerações seguintes sem o menor questionamento.

  17. Modeling and Implementing Two-Stage AdaBoost for Real-Time Vehicle License Plate Detection

    Directory of Open Access Journals (Sweden)

    Moon Kyou Song

    2014-01-01

    Full Text Available License plate (LP detection is the most imperative part of the automatic LP recognition system. In previous years, different methods, techniques, and algorithms have been developed for LP detection (LPD systems. This paper proposes to automatical detection of car LPs via image processing techniques based on classifier or machine learning algorithms. In this paper, we propose a real-time and robust method for LPD systems using the two-stage adaptive boosting (AdaBoost algorithm combined with different image preprocessing techniques. Haar-like features are used to compute and select features from LP images. The AdaBoost algorithm is used to classify parts of an image within a search window by a trained strong classifier as either LP or non-LP. Adaptive thresholding is used for the image preprocessing method applied to those images that are of insufficient quality for LPD. This method is of a faster speed and higher accuracy than most of the existing methods used in LPD. Experimental results demonstrate that the average LPD rate is 98.38% and the computational time is approximately 49 ms.

  18. Reconsidering Styles of Regulatory Enforcement

    DEFF Research Database (Denmark)

    May, Peter J.; Winter, Søren

    2000-01-01

    This study addresses enforcement styles of regulatory inspectors, based on an examination of the municipal enforcement of agro-environmental policies in Denmark. Our findings make three contributions to the regulatory literature. One contribution is to add empirical support for theorizing about...

  19. Disclosure as a regulatory tool

    DEFF Research Database (Denmark)

    Sørensen, Karsten Engsig

    2006-01-01

    The chapter analyses how disclure can be used as a regulatory tool and analyses how it has been applied so far in the area of financial market law and consumer law.......The chapter analyses how disclure can be used as a regulatory tool and analyses how it has been applied so far in the area of financial market law and consumer law....

  20. Regulatory focus in groupt contexts

    NARCIS (Netherlands)

    Faddegon, Krispijn Johannes

    2009-01-01

    The thesis examines the influence of group processes on the regulatory focus of individual group members. It is demonstrated that the group situation can affect group members' regulatory focus both in a top-down fashion (via the identitiy of the group) and in a bottom-up fashion (emerging from the

  1. Reconsidering Styles of Regulatory Enforcement

    DEFF Research Database (Denmark)

    J. May, Peter; Winter, Søren

    2007-01-01

    This study addresses enforcement styles of regulatory inspectors based on an examination of the municipal enforcement of agro-environmental policies in Denmark. Our findings make three contributions to the regulatory literature. One contribution is to add empirical support for theorizing about...

  2. Examining the relationship between health locus of control and God Locus of Health Control: Is God an internal or external source?

    Science.gov (United States)

    Boyd, Joni M; Wilcox, Sara

    2017-11-01

    For many people, the influence of believing in a higher power can elicit powerful effects. This study examined the relationship between God control, health locus of control, and frequency of religious attendance within 838 college students through online surveys. Regression analysis showed that chance and external locus of control and frequency of religious attendance were significant and positive predictors of God Locus of Health Control. The association of powerful others external locus of control and God Locus of Health Control differed by race (stronger in non-Whites than Whites) and somewhat by gender (stronger in women than men). For some people, the role of a supreme being, or God, should be considered when designing programs for improving health behaviors.

  3. Regulatory Streamlining and Improvement

    Energy Technology Data Exchange (ETDEWEB)

    Mark A. Carl

    2006-07-11

    The Interstate Oil and Gas Compact Commission (IOGCC) engaged in numerous projects outlined under the scope of work discussed in the United States Department of Energy (DOE) grant number DE-FC26-04NT15456 awarded to the IOGCC. Numerous projects were completed that were extremely valuable to state oil and gas agencies as a result of work performed utilizing resources provided by the grant. There are numerous areas in which state agencies still need assistance. This additional assistance will need to be addressed under future scopes of work submitted annually to DOE's Project Officer for this grant. This report discusses the progress of the projects outlined under the grant scope of work for the 2005-2006 areas of interest, which are as follows: Area of Interest No. 1--Regulatory Streamlining and Improvement: This area of interest continues to support IOGCC's regulatory streamlining efforts that include the identification and elimination of unnecessary duplications of efforts between and among state and federal programs dealing with exploration and production on public lands. Area of Interest No. 2--Technology: This area of interest seeks to improve efficiency in states through the identification of technologies that can reduce costs. Area of Interest No. 3--Training and Education: This area of interest is vital to upgrading the skills of regulators and industry alike. Within the National Energy Policy, there are many appropriate training and education opportunities. Education was strongly endorsed by the President's National Energy Policy Development group. Acting through the governors offices, states are very effective conduits for the dissemination of energy education information. While the IOGCC favors the development of a comprehensive, long-term energy education plan, states are also supportive of immediate action on important concerns, such as energy prices, availability and conservation. Area of Interest No. 4--Resource Assessment and

  4. Internationalization of regulatory requirements.

    Science.gov (United States)

    Juillet, Y

    2003-02-01

    The aim of harmonisation of medicines regulatory requirements is to allow the patient quicker access to new drugs and to avoid animal and human duplications. Harmonisation in the European Union (EU) is now completed, and has led to the submission of one dossier in one language study leading to European marketing authorizations, thanks in particular to efficacy guidelines published at the European level. With the benefit of the European experience since 1989, more than 40 guidelines have been harmonised amongst the EU, Japan and the USA through the International Conference on Harmonisation (ICH). ICH is a unique process gathering regulators and industry experts from the three regions. Its activity is built on expertise and trust. The Common Technical Document (CTD), an agreed common format for application in the three regions, is a logical follow-up to the ICH first phase harmonising the content of the dossier. The CTD final implementation in July 2003 will have considerable influence on the review process and on the exchange of information in the three regions.

  5. Asymmetrical distribution of non-conserved regulatory sequences at PHOX2B is reflected at the ENCODE loci and illuminates a possible genome-wide trend

    Directory of Open Access Journals (Sweden)

    McCallion Andrew S

    2009-01-01

    Full Text Available Abstract Background Transcriptional regulatory elements are central to development and interspecific phenotypic variation. Current regulatory element prediction tools rely heavily upon conservation for prediction of putative elements. Recent in vitro observations from the ENCODE project combined with in vivo analyses at the zebrafish phox2b locus suggests that a significant fraction of regulatory elements may fall below commonly applied metrics of conservation. We propose to explore these observations in vivo at the human PHOX2B locus, and also evaluate the potential evidence for genome-wide applicability of these observations through a novel analysis of extant data. Results Transposon-based transgenic analysis utilizing a tiling path proximal to human PHOX2B in zebrafish recapitulates the observations at the zebrafish phox2b locus of both conserved and non-conserved regulatory elements. Analysis of human sequences conserved with previously identified zebrafish phox2b regulatory elements demonstrates that the orthologous sequences exhibit overlapping regulatory control. Additionally, analysis of non-conserved sequences scattered over 135 kb 5' to PHOX2B, provides evidence of non-conserved regulatory elements positively biased with close proximity to the gene. Furthermore, we provide a novel analysis of data from the ENCODE project, finding a non-uniform distribution of regulatory elements consistent with our in vivo observations at PHOX2B. These observations remain largely unchanged when one accounts for the sequence repeat content of the assayed intervals, when the intervals are sub-classified by biological role (developmental versus non-developmental, or by gene density (gene desert versus non-gene desert. Conclusion While regulatory elements frequently display evidence of evolutionary conservation, a fraction appears to be undetected by current metrics of conservation. In vivo observations at the PHOX2B locus, supported by our analyses of in

  6. Fine mapping a self-fertility locus in perennial ryegrass.

    Science.gov (United States)

    Do Canto, Javier; Studer, Bruno; Frei, Ursula; Lübberstedt, Thomas

    2017-12-15

    A self-fertility locus was fine mapped to a 1.6 cM region on linkage group 5 in a perennial ryegrass population. This locus was the main determinant of pollen self-compatibility. In grasses, self-incompatibility (SI) is characterized by a two-loci gametophytic (S and Z) mechanism acting together in the recognition and inhibition of self-pollen. Mutations affecting the expression of SI have been reported in a few grass species. In perennial ryegrass (Lolium perenne L.), a mutation independent from S and Z, and mapping on linkage group 5 (LG 5), was previously reported to produce self-fertile plants. Here, we describe fine mapping of the self-fertility (SF) gene in a perennial ryegrass population and determine whether there is any effect of other genomic regions on the pollen compatibility. The phenotypic segregation of SF showed a bimodal distribution with one mean at 49% pollen compatibility and the other at 91%. Marker-trait association analysis showed that only markers on LG 5 were significantly associated with the trait. A single gene model explained 82% of the observed variability and no effects of the other regions were detected. Using segregation and linkage analysis, the SF locus was located to a 1.6 cM region on LG 5. The flanking marker sequences were aligned to rice and Brachypodium distachyon reference genomes to estimate the physical distance. We provide markers tightly linked to SF that can be used for introgression of this trait into advanced breeding germplasm. Moreover, our results represent a further step towards the identification of the SF gene in LG 5.

  7. The construction of a normative scale of locus of control

    Directory of Open Access Journals (Sweden)

    Johann M. Schepers

    2005-10-01

    Full Text Available The primary objective of the study was to construct a normative scale of locus of control for use with students and adults. A corollary of the study was to establish the personality, interest and cognitive correlates of locus of control. Conceptually the instrument is based on attribution theory and on social learning theory. The first edition of the Locus of Control Inventory (LCI was applied to 356 first-year university students during 1994. A factor analysis of the 65 items of the inventory yielded three factors. The factors were interpreted as Autonomy, Internal Control and External Control. Three scales, corresponding to the three factors, were constructed, and yielded reliability coefficients of 0,80; 0,77 and 0,81 respectively. Following this the cognitive, interest and personality correlates of the LCI were determined. The implications of the findings are discussed. Opsomming Die hoofdoel van die studie was die konstruksie van ’n normatiewe skaal van lokus van beheer vir gebruik met studente en volwassenes. ’n Newe-doelwit van die studie was om die persoonlikheids-, belangstellings- en kognitiewe korrelate van lokus van beheer te bepaal. Konseptueel is die instrument op attribusieteorie en sosiale-leerteorie gebaseer. Die eerste-uitgawe van die Lokus van Beheervraelys (LvB is op 356 eerstejaaruniversiteitstudente toegepas gedurende 1994. ’n Faktorontleding van die 65 items van die vraelys is gedoen en het drie faktore opgelewer. Die faktore is as Outonomie, Interne Beheer en Eksterne Beheer geïnterpreteer. Voorts is drie skale wat ooreenstem met die drie faktore, gekonstrueer en het betroubaarhede van 0,80; 0,77 en 0,81, onderskeidelik, opgelewer. Vervolgens is die kognitiewe, belangstellings- en persoonlikheidskorrelate van die LvB bepaal. Die implikasies van die bevindinge word bespreek.

  8. Diverse Cis-Regulatory Mechanisms Contribute to Expression Evolution of Tandem Gene Duplicates.

    Science.gov (United States)

    Baudouin-Gonzalez, Luís; Santos, Marília A; Tempesta, Camille; Sucena, Élio; Roch, Fernando; Tanaka, Kohtaro

    2017-12-01

    Pairs of duplicated genes generally display a combination of conserved expression patterns inherited from their unduplicated ancestor and newly acquired domains. However, how the cis-regulatory architecture of duplicated loci evolves to produce these expression patterns is poorly understood. We have directly examined the gene-regulatory evolution of two tandem duplicates, the Drosophila Ly6 genes CG9336 and CG9338, which arose at the base of the drosophilids between 40 and 60 Ma. Comparing the expression patterns of the two paralogs in four Drosophila species with that of the unduplicated ortholog in the tephritid Ceratitis capitata, we show that they diverged from each other as well as from the unduplicated ortholog. Moreover, the expression divergence appears to have occurred close to the duplication event and also more recently in a lineage-specific manner. The comparison of the tissue-specific cis-regulatory modules (CRMs) controlling the paralog expression in the four Drosophila species indicates that diverse cis-regulatory mechanisms, including the novel tissue-specific enhancers, differential inactivation, and enhancer sharing, contributed to the expression evolution. Our analysis also reveals a surprisingly variable cis-regulatory architecture, in which the CRMs driving conserved expression domains change in number, location, and specificity. Altogether, this study provides a detailed historical account that uncovers a highly dynamic picture of how the paralog expression patterns and their underlying cis-regulatory landscape evolve. We argue that our findings will encourage studying cis-regulatory evolution at the whole-locus level to understand how interactions between enhancers and other regulatory levels shape the evolution of gene expression. © The Author 2017. Published by Oxford University Press on behalf of the Society for Molecular Biology and Evolution.

  9. Locus of the apices of projectile trajectories under constant drag

    Science.gov (United States)

    Hernández-Saldaña, H.

    2017-11-01

    Using the hodograph method, we present an analytical solution for projectile coplanar motion under constant drag, parametrised by the velocity angle. We find the locus formed by the apices of the projectile trajectories, and discuss its implementation for the motion of a particle on an inclined plane in presence of Coulomb friction. The range and time of flight are obtained numerically, and we find that the optimal launching angle is smaller than in the drag-free case. This is a good example of a problem with constant dissipation of energy that includes curvature; it is appropriate for intermediate courses of mechanics.

  10. [Polymorphism of the DXS1062 locus in a Polish population].

    Science.gov (United States)

    Cybulska, Lidia; Szczerkowska, Zofia

    2004-01-01

    This paper presents the results of a population study of a dinucleotide STR marker DXS1062. Blood samples were obtained from unrelated adult individuals (males and females) living in the northern part of Poland. In the analyzed population, 21 different phenotypes and 9 alleles of the DXS1062 locus were found. The alleles were sequenced and used for the construction of an allelic ladder. The nomenclature in accordance with ISFG guidelines was proposed. The most frequent alleles were 20 and 21. Statistical parameters (PR, PM, PD, PIC) showed that the examined system is useful in forensic medicine.

  11. Rapid Multi-Locus Sequence Typing Using Microfluidic Biochips

    Science.gov (United States)

    2010-05-12

    Chlamydia (manuscript in preparation) and performed pilot studies on Staphylococcus aureus and Streptoccus pneumoniae (Data S4 and Text S2). Another potential...Found at: doi:10.1371/journal.pone.0010595.s009 (0.00 MB TXT) Text S2 mMLST sequencing of S. aureus and S. pneumoniae . Found at: doi:10.1371...provided S. aureus and S. pneumoniae strains. This publication made use of the Bacillus cereus Multi Locus Sequence Typing website (http://pubmlst.org

  12. Measurement of supernatural belief: sex differences and locus of control.

    Science.gov (United States)

    Randall, T M; Desrosiers, M

    1980-10-01

    Although we live in an age dominated by science and technology, there exists an increasingly popular anti-science sentiment. This study describes the development of a scale to assess the degree of personal acceptance of supernatural causality versus acceptance of scientific explanation. In addition to the psychometric data concerning validity and reliability of the scale, data are presented which showed the personality factor of supernaturalism to be independent of orthodox religious attitudes. Results indicated a significantly greater supernatural acceptance for women, and a positive relation of supernaturalism with external locus of control.

  13. Locus of control and its relationship with mental health and adjustment among adolescent females

    Directory of Open Access Journals (Sweden)

    Madhu Jain

    2015-01-01

    Full Text Available Objective: There exists a plethora of researches which have identified the role of Locus of Control in maintaining sound mental health and adjustment. The present study examined the relationship of Locus of Control with Mental Health & overall Adjustment among adolescent females. Method: The participants consisted of 50 adolescent females. Mental Health Battery designed by Singh, Gupta (2000, Rotter′s Locus of Control Scale (1966 & Adjustment Inventory for College Students by Sinha & Singh (1995 were administered. Findings: The findings of the study revealed that adolescent females who possess internal locus of control showed better mental health & overall adjustment pattern which includes home, social, emotional, educational domains and health adjustment domain than those who possess external locus of control. Conclusion: The study highlights the pervasive influence of internal & external locus of control on mental health & adjustment among adolescent females.

  14. Perbedaan Daya Hambat Bakteri dari Propolis Cair yang Ada di Pasaran Terhadap Escherichia Coli dan Staphylococcus Aureus Secara In Vitro

    Directory of Open Access Journals (Sweden)

    Bangun Azhari Yusuf

    2015-09-01

    Full Text Available Abstrak Propolis adalah zat yang digunakan lebah melindungi sarangnya dari berbagai ancaman. Komponen utama propolis adalah resin yang dikumpulkan lebah dan dicampur dengan air liurnya. Manusia juga menggunakan propolis sebagai obat berbagai penyakit, seperti infeksi bakteri. Propolis memiliki kemampuan antibakteri terhadap Escherichiacoli dan Staphylococcus aureus. Kualitas dan jenis propolis sesuai dengan komposisi kimia, iklim dan tempat berkembang biak. Tujuan penelitian ini adalah melihat perbedaan daya hambat bakteri Propolis cair 1 dan Propolis cair 2 yang ada di pasaran terhadap Escherichia coli dan Staphylococcus aureus secara in vitro. Propolis yang akan diuji adalah propolis cair yang ada di pasaran dipilih dua secara acak. Penelitian dilaksanakan pada bulan Januari 2013 di laboratorium Mikrobiologi Fakultas Kedokteran Universitas Andalas. Jenis penelitian eksperimentalmenggunakan metode difusi (metode cakram dan analitik dengan menghubungkan perbedaan kedua propolis sebagai antibakteri. Hasil penelitian ini menunjukkan propolis cair 1 dan propolis cair 2 yang ada di pasaran tidak memiliki efek antibakteri terhadap Escherichia coli dan terdapat perbedaan daya hambat bakteri dari kedua propolisterhadap Staphylococcus aureus. Propolis cair 2 (diklaim berasal dari Selandia baru memiliki daya hambat bakteri yang lebih baik daripada propolis cair 1 (diklaim berasal dari Malaysia.Kata kunci: propolis cair, perbedaan daya hambat bakteri, Escherichia coli, Staphylococcus aureusAbstract Propolis is substance which use to protect bee hive from various threat. The main component of propolis is resin which is collected and mixed with saliva. The human also use propolis as a treatment against various illness such as bacterial infection. Propolis has an antibacterial effect to Escherichia coli and Stahpylococcus aureus. The quality and type of propolis is also in accordance with chemical composition, climate and their breeding location. The

  15. Healthcare regulatory concepts in Brazil.

    Science.gov (United States)

    Oliveira, Robson Rocha de; Elias, Paulo Eduardo Mangeon

    2012-06-01

    The healthcare regulatory concepts used in Brazilian scientific publications on healthcare management were reviewed. A typo-logical classification for regulatory concepts was developed from the most current ideas in five disciplines: life sciences, law, economics, sociology and political science. Four ideas stood out: control, balance, adaptation and direction, with greatest emphasis on the technical nature of regulation. The political nature of regulation was secondary. It was considered that dis-cussion of healthcare regulatory concepts was connected with comprehension of the role that the state plays in this sector. De-finition of the forms of state intervention is the key convergence point between the different ways of conceptualizing healthcare regulation.

  16. The relationship between the perception of own locus of control and aggression of adolescent boys

    OpenAIRE

    Lettie Breet; Chris Myburgh; Marie Poggenpoel

    2010-01-01

    Aggression is increasingly seen in most parts of South African society. Aggressive behaviour of boys in secondary school often results from frustrations caused by perceived high expectations of others regarding the role, locus of control, and personality of boys. Locus of control plays an important role in a person's perception concerning a situation and possible reactions to what is happening, or should be happening. A 56-item questionnaire, based on Rotter's "Locus of control" questionnaire...

  17. The Contribution of Locus of Control to Academic Procrastination in Islamic Education Management Students in Indonesia

    OpenAIRE

    Juliana Batubara

    2017-01-01

    This study aimed to describe the locus of control and academic procrastination, and investigate whether there is significance contributions of locus of control on student academic procrastination. This research was conducted by the Ex post-facto method was used in this study, where the data taken from two set of questionnaires. Proportional Stratified Random Sampling was used. There were 107 students involved this study. The results showed that the locus of control is in average level, meanwh...

  18. Prevalence of Porphyromonas gingivalis Four rag Locus Genotypes in Patients of Orthodontic Gingivitis and Periodontitis

    OpenAIRE

    Liu, Yi; Zhang, Yujie; Wang, Lili; Guo, Yang; Xiao, Shuiqing

    2013-01-01

    Porphyromonas gingivalis is considered as a major etiological agent in periodontal diseases and implied to result in gingival inflammation under orthodontic appliance. rag locus is a pathogenicity island found in Porphyromonas gingivalis. Four rag locus variants are different in pathogenicity of Porphyromonas gingivalis. Moreover, there are different racial and geographic differences in distribution of rag locus genotypes. In this study, we assessed the prevalence of Porphyromonas gingivalis ...

  19. The Danish Regulatory Reform of Telecommunications

    DEFF Research Database (Denmark)

    Skouby, Knud Erik

    1998-01-01

    An overview of the liberalisation process and regulatory reform of telecommunications in Denmark......An overview of the liberalisation process and regulatory reform of telecommunications in Denmark...

  20. Regulatory lymphocytes in thyroid orbitopathy and autoimmune thyroid diseases.

    Science.gov (United States)

    Siomkajło, Marta; Dybko, Jarosław; Daroszewski, Jacek

    2016-12-31

    Thyroid orbitopathy (OT), as an organ‑specific autoimmune disease, is a result of immune dysregulation leading to loss of control over inflammation directed against self‑antigens. The source of the autoreactive lymphocytes is the impairment of central tolerance as well as their induction on the periphery by modified or sequestered by that time antigens. Active suppression by the various subpopulations of regulatory lymphocytes (Lreg) acts as a counterbalance to the proinflammatory factors and is aimed at dampening pathological reaction. Thereby, qualitative or quantitative shortfalls of Lreg play a critical role in the development of autoimmune diseases. Giving direction to Lreg‑based therapy and restoring the dynamic balance seem to be of crucial importance, especially in diseases such as OT, where the causative self‑antigen is not yet unequivocally elucidated. Technical difficulties with isolation and assessment of Lreg function in vitro as well as lack of unification of research protocols make the findings non‑comparable, inconclusive and sometimes even conflicting. Lack of a Tregs' (regulatory T cells) specific set of surface markers makes the demethylation status analysis of TSDR (Treg specific demethylated region) FOXP3 (forkhead box P3) locus the most reliable method of their quantification. Despite numerous discrepancies between research findings, most of them point to Lreg's pivotal role in immune disturbances, which form the basis of OT and autoimmune thyroid diseases (AITD).

  1. Regulatory lymphocytes in thyroid orbitopathy and autoimmune thyroid diseases

    Directory of Open Access Journals (Sweden)

    Marta Siomkajło

    2016-12-01

    Full Text Available Thyroid orbitopathy (OT, as an organ‑specific autoimmune disease, is a result of immune dysregulation leading to loss of control over inflammation directed against self‑antigens. The source of the autoreactive lymphocytes is the impairment of central tolerance as well as their induction on the periphery by modified or sequestered by that time antigens. Active suppression by the various subpopulations of regulatory lymphocytes (Lreg acts as a counterbalance to the proinflammatory factors and is aimed at dampening pathological reaction. Thereby, qualitative or quantitative shortfalls of Lreg play a critical role in the development of autoimmune diseases. Giving direction to Lreg‑based therapy and restoring the dynamic balance seem to be of crucial importance, especially in diseases such as OT, where the causative self‑antigen is not yet unequivocally elucidated.Technical difficulties with isolation and assessment of Lreg function in vitro as well as lack of unification of research protocols make the findings non‑comparable, inconclusive and sometimes even conflicting. Lack of a Tregs’ (regulatory T cells specific set of surface markers makes the demethylation status analysis of TSDR (Treg specific demethylated region FOXP3 (forkhead box P3 locus the most reliable method of their quantification. Despite numerous discrepancies between research findings, most of them point to Lreg’s pivotal role in immune disturbances, which form the basis of OT and autoimmune thyroid diseases (AITD.

  2. POEM: Identifying Joint Additive Effects on Regulatory Circuits.

    Science.gov (United States)

    Botzman, Maya; Nachshon, Aharon; Brodt, Avital; Gat-Viks, Irit

    2016-01-01

    Expression Quantitative Trait Locus (eQTL) mapping tackles the problem of identifying variation in DNA sequence that have an effect on the transcriptional regulatory network. Major computational efforts are aimed at characterizing the joint effects of several eQTLs acting in concert to govern the expression of the same genes. Yet, progress toward a comprehensive prediction of such joint effects is limited. For example, existing eQTL methods commonly discover interacting loci affecting the expression levels of a module of co-regulated genes. Such "modularization" approaches, however, are focused on epistatic relations and thus have limited utility for the case of additive (non-epistatic) effects. Here we present POEM (Pairwise effect On Expression Modules), a methodology for identifying pairwise eQTL effects on gene modules. POEM is specifically designed to achieve high performance in the case of additive joint effects. We applied POEM to transcription profiles measured in bone marrow-derived dendritic cells across a population of genotyped mice. Our study reveals widespread additive, trans-acting pairwise effects on gene modules, characterizes their organizational principles, and highlights high-order interconnections between modules within the immune signaling network. These analyses elucidate the central role of additive pairwise effect in regulatory circuits, and provide computational tools for future investigations into the interplay between eQTLs. The software described in this article is available at csgi.tau.ac.il/POEM/.

  3. Thorough investigation of a canine autoinflammatory disease (AID confirms one main risk locus and suggests a modifier locus for amyloidosis.

    Directory of Open Access Journals (Sweden)

    Mia Olsson

    Full Text Available Autoinflammatory disease (AID manifests from the dysregulation of the innate immune system and is characterised by systemic and persistent inflammation. Clinical heterogeneity leads to patients presenting with one or a spectrum of phenotypic signs, leading to difficult diagnoses in the absence of a clear genetic cause. We used separate genome-wide SNP analyses to investigate five signs of AID (recurrent fever, arthritis, breed specific secondary dermatitis, otitis and systemic reactive amyloidosis in a canine comparative model, the pure bred Chinese Shar-Pei. Analysis of 255 DNA samples revealed a shared locus on chromosome 13 spanning two peaks of association. A three-marker haplotype based on the most significant SNP (p<2.6×10(-8 from each analysis showed that one haplotypic pair (H13-11 was present in the majority of AID individuals, implicating this as a shared risk factor for all phenotypes. We also noted that a genetic signature (F ST distinguishing the phenotypic extremes of the breed specific Chinese Shar-Pei thick and wrinkled skin, flanked the chromosome 13 AID locus; suggesting that breed development and differentiation has played a parallel role in the genetics of breed fitness. Intriguingly, a potential modifier locus for amyloidosis was revealed on chromosome 14, and an investigation of candidate genes from both this and the chromosome 13 regions revealed significant (p<0.05 renal differential expression in four genes previously implicated in kidney or immune health (AOAH, ELMO1, HAS2 and IL6. These results illustrate that phenotypic heterogeneity need not be a reflection of genetic heterogeneity, and that genetic modifiers of disease could be masked if syndromes were not first considered as individual clinical signs and then as a sum of their component parts.

  4. External locus of control contributes to racial disparities in memory and reasoning training gains in ACTIVE.

    Science.gov (United States)

    Zahodne, Laura B; Meyer, Oanh L; Choi, Eunhee; Thomas, Michael L; Willis, Sherry L; Marsiske, Michael; Gross, Alden L; Rebok, George W; Parisi, Jeanine M

    2015-09-01

    Racial disparities in cognitive outcomes may be partly explained by differences in locus of control. African Americans report more external locus of control than non-Hispanic Whites, and external locus of control is associated with poorer health and cognition. The aims of this study were to compare cognitive training gains between African American and non-Hispanic White participants in the Advanced Cognitive Training for Independent and Vital Elderly (ACTIVE) study and determine whether racial differences in training gains are mediated by locus of control. The sample comprised 2,062 (26% African American) adults aged 65 and older who participated in memory, reasoning, or speed training. Latent growth curve models evaluated predictors of 10-year cognitive trajectories separately by training group. Multiple group modeling examined associations between training gains and locus of control across racial groups. Compared to non-Hispanic Whites, African Americans evidenced less improvement in memory and reasoning performance after training. These effects were partially mediated by locus of control, controlling for age, sex, education, health, depression, testing site, and initial cognitive ability. African Americans reported more external locus of control, which was associated with smaller training gains. External locus of control also had a stronger negative association with reasoning training gain for African Americans than for Whites. No racial difference in training gain was identified for speed training. Future intervention research with African Americans should test whether explicitly targeting external locus of control leads to greater cognitive improvement following cognitive training. (c) 2015 APA, all rights reserved).

  5. Shiftwork Locus of Control, Situational and Behavioural Effects on Sleepiness and Fatigue in Shiftworkers

    National Research Council Canada - National Science Library

    SMITH, Lawrence; TANIGAWA, Takeshi; TAKAHASHI, Masaya; MUTOU, Keiko; TACHIBANA, Naoko; KAGE, Yoshiko; ISO, Hiroyasu

    2005-01-01

    .... Power company shiftworkers completed a questionnaire that measured age/experience, number of dependents, shiftwork locus of control, morningness-eveningness, workload and sleep/health-related behaviours...

  6. Investigation of the 5q33.3 longevity locus and age-related phenotypes

    OpenAIRE

    Nygaard, Marianne; Thinggaard, Mikael; Christensen, Kaare; Christiansen, Lene

    2017-01-01

    A large meta-analysis recently found the 5q33.3 locus to be associated with survival to ≥ 90 years and lower all-cause mortality, thus suggesting it as a third human longevity locus alongside APOE and FOXO3A. The 5q33.3 locus has previously been associated with blood pressure regulation and cardiovascular diseases in middle-aged individuals. However, part of the influence on mortality appears to be independent of cardiovascular phenotypes, and the role of the 5q33.3 locus in longevity and sur...

  7. Structural zinc(II thiolate complexes relevant to the modeling of Ada repair protein: Application toward alkylation reactions

    Directory of Open Access Journals (Sweden)

    Mohamed M. Ibrahim

    2014-11-01

    Full Text Available The TtZn(II-bound perchlorate complex [TtZn–OClO3] 1 (Ttxyly = hydrotris[N-xylyl-thioimidazolyl]borate was used for the synthesis of zinc(II-bound ethanthiothiol complex [TtZn–SCH2CH3] 2 and its hydrogen-bond containing analog Tt–ZnSCH2CH2–NH(COOC(CH33 3. These thiolate complexes were examined as structural models for the active sites of Ada repair protein toward methylation reactions. The Zn[S3O] coordination sphere in complex 1 includes three thione donors from the ligand Ttixyl and one oxygen donor from the perchlorate coligand in ideally tetrahedral arrangement around the zinc center. The average Zn(1–S(thione bond length is 2.344 Å, and the Zn(1–O(1 bond length is 1.917 Å.

  8. MONEDAS ESPECIALMENTE ACUÑADAS PARA LOS LAZARETOS Comisión Permanente de Museo de Historia de la Medicina

    Directory of Open Access Journals (Sweden)

    Academia Nacional de Medicina

    2011-04-01

    Full Text Available

    Como una medida de higiene, pensando que la lepra podría contagiarse de persona a persona, por contacto directo, la Dirección Nacional de Higiene  solicitó al Gobierno, la fabricación de unas monedas  para que circularan únicamente en los leprocomios,  y que fueron acuñadas con una aleación de Níquel 25% y Cobre 75%. 

    Para que se fabricaran dichas monedas, el Gobierno expidió los decretos 1452, 1562 y 2209 del año 1901. Estas monedas popularmente se conocían con el nombre de –Coscojas– que significaba poca cosa y se produjeron durante los años 1901, 1907, 1921 y 1928.

  9. Regulatory Snapshots: integrative mining of regulatory modules from expression time series and regulatory networks.

    Directory of Open Access Journals (Sweden)

    Joana P Gonçalves

    Full Text Available Explaining regulatory mechanisms is crucial to understand complex cellular responses leading to system perturbations. Some strategies reverse engineer regulatory interactions from experimental data, while others identify functional regulatory units (modules under the assumption that biological systems yield a modular organization. Most modular studies focus on network structure and static properties, ignoring that gene regulation is largely driven by stimulus-response behavior. Expression time series are key to gain insight into dynamics, but have been insufficiently explored by current methods, which often (1 apply generic algorithms unsuited for expression analysis over time, due to inability to maintain the chronology of events or incorporate time dependency; (2 ignore local patterns, abundant in most interesting cases of transcriptional activity; (3 neglect physical binding or lack automatic association of regulators, focusing mainly on expression patterns; or (4 limit the discovery to a predefined number of modules. We propose Regulatory Snapshots, an integrative mining approach to identify regulatory modules over time by combining transcriptional control with response, while overcoming the above challenges. Temporal biclustering is first used to reveal transcriptional modules composed of genes showing coherent expression profiles over time. Personalized ranking is then applied to prioritize prominent regulators targeting the modules at each time point using a network of documented regulatory associations and the expression data. Custom graphics are finally depicted to expose the regulatory activity in a module at consecutive time points (snapshots. Regulatory Snapshots successfully unraveled modules underlying yeast response to heat shock and human epithelial-to-mesenchymal transition, based on regulations documented in the YEASTRACT and JASPAR databases, respectively, and available expression data. Regulatory players involved in

  10. Anti-regulatory T cells

    DEFF Research Database (Denmark)

    Andersen, Mads Hald

    2017-01-01

    Our initial understanding of immune-regulatory cells was based on the discovery of suppressor cells that assure peripheral T-cell tolerance and promote immune homeostasis. Research has particularly focused on the importance of regulatory T cells (Tregs) for immune modulation, e.g. directing host...... responses to tumours or inhibiting autoimmunity development. However, recent studies report the discovery of self-reactive pro-inflammatory T cells—termed anti-regulatory T cells (anti-Tregs)—that target immune-suppressive cells. Thus, regulatory cells can now be defined as both cells that suppress immune......-reactive T cells that recognize such targets may be activated due to the strong activation signal given by their cognate targets. The current review describes the existing knowledge regarding these self-reactive anti-Tregs, providing examples of antigen-specific anti-Tregs and discussing their possible roles...

  11. Robust Grape Cluster Detection in a Vineyard by Combining the AdaBoost Framework and Multiple Color Components.

    Science.gov (United States)

    Luo, Lufeng; Tang, Yunchao; Zou, Xiangjun; Wang, Chenglin; Zhang, Po; Feng, Wenxian

    2016-12-10

    The automatic fruit detection and precision picking in unstructured environments was always a difficult and frontline problem in the harvesting robots field. To realize the accurate identification of grape clusters in a vineyard, an approach for the automatic detection of ripe grape by combining the AdaBoost framework and multiple color components was developed by using a simple vision sensor. This approach mainly included three steps: (1) the dataset of classifier training samples was obtained by capturing the images from grape planting scenes using a color digital camera, extracting the effective color components for grape clusters, and then constructing the corresponding linear classification models using the threshold method; (2) based on these linear models and the dataset, a strong classifier was constructed by using the AdaBoost framework; and (3) all the pixels of the captured images were classified by the strong classifier, the noise was eliminated by the region threshold method and morphological filtering, and the grape clusters were finally marked using the enclosing rectangle method. Nine hundred testing samples were used to verify the constructed strong classifier, and the classification accuracy reached up to 96.56%, higher than other linear classification models. Moreover, 200 images captured under three different illuminations in the vineyard were selected as the testing images on which the proposed approach was applied, and the average detection rate was as high as 93.74%. The experimental results show that the approach can partly restrain the influence of the complex background such as the weather condition, leaves and changing illumination.

  12. Robust Grape Cluster Detection in a Vineyard by Combining the AdaBoost Framework and Multiple Color Components

    Directory of Open Access Journals (Sweden)

    Lufeng Luo

    2016-12-01

    Full Text Available The automatic fruit detection and precision picking in unstructured environments was always a difficult and frontline problem in the harvesting robots field. To realize the accurate identification of grape clusters in a vineyard, an approach for the automatic detection of ripe grape by combining the AdaBoost framework and multiple color components was developed by using a simple vision sensor. This approach mainly included three steps: (1 the dataset of classifier training samples was obtained by capturing the images from grape planting scenes using a color digital camera, extracting the effective color components for grape clusters, and then constructing the corresponding linear classification models using the threshold method; (2 based on these linear models and the dataset, a strong classifier was constructed by using the AdaBoost framework; and (3 all the pixels of the captured images were classified by the strong classifier, the noise was eliminated by the region threshold method and morphological filtering, and the grape clusters were finally marked using the enclosing rectangle method. Nine hundred testing samples were used to verify the constructed strong classifier, and the classification accuracy reached up to 96.56%, higher than other linear classification models. Moreover, 200 images captured under three different illuminations in the vineyard were selected as the testing images on which the proposed approach was applied, and the average detection rate was as high as 93.74%. The experimental results show that the approach can partly restrain the influence of the complex background such as the weather condition, leaves and changing illumination.

  13. EFEITOS DA ORIENTAÇÃO DA ATIVIDADE FÍSICA EM PACIENTES COM OSTEOARTRITE AVANÇADA DO JOELHO

    Directory of Open Access Journals (Sweden)

    Ricardo de Souza Campos Fernandes

    Full Text Available RESUMO Introdução: A osteoartrite (OA do joelho atinge 20% da população mundial e 70% a 80% dos indivíduos com mais de 65 anos. Caracteriza-se por dor e incapacidade funcional determinada pela degeneração da cartilagem articular e do osso subcondral. Seu tratamento conservador inclui a prática de exercícios físicos. Objetivo : Determinar os efeitos da prescrição e orientação da atividade física em pacientes com OA avançada do joelho. Métodos: Foram incluídos 23 pacientes submetidos a atividade física com orientação e avaliados no momento inicial, aos três e aos seis meses, pelo sistema de pontuação EVA e WOMAC (3 domínios. Foi utilizado o modelo linear generalizado e nas situações com diferença significante entre os tempos de avaliação, foram feitas comparações múltiplas com o teste de Bonferroni, com nível de significância de cinco por cento. Resultados : Houve diferença estatisticamente significante entre as pontuações EVA e WOMAC no início do estudo e aos três e seis meses. Esses resultados foram independentes do grau de OA e de doença uni ou bilateral. Conclusão : A orientação da atividade física no tratamento de pacientes com OA avançada de joelho, melhora a função articular e deve ser considerada inclusive nos casos com indicação de artroplastia.

  14. [Locus of control in girls with anorexia readiness syndrome].

    Science.gov (United States)

    Jaros, Katarzyna; Oszwa, Urszula

    2014-01-01

    The aim of the research was to indicate whether there are differences between locus of control (LOC) in girls with anorexia readiness syndrome (ARS) and without this syndrome. There was also a question about the relationship between LOC and the tendency to respond in incorrect attitudes towards food, eating and their bodies under stress. The sample consisted of girls aged 13-18 years randomly selected from five public Polish middle and high schools. Tools: 1) Eating Attitudes Questionnaire (EAQ) by B. Ziółkowska; 2) Locus of Control Questionnaire (LOCQ) by G. Krasowicz, A. Kurzyp-Wojnarska, to assess LOC of the subjects. The criterion group (N=23) was formed by girls who received high score in EAQ (signs of ARS) in the first stage of research (N=189). The control group (N = 23) were girls who received a low score in EAQ (no signs of ARS). Subjects with ARS were characterized by more external LOC than girls without any signs of this syndrome (t = -2.898; p < 0.01). The results did not confirm the hypothesis about the relationship between LOC and the tendency to respond by abnormal attitude to eating and own body in difficult situations in both groups. In pathogenesis of ARS where anorexic behaviors can become a way to a regain lost control, LOC may play a role as a mediating variable rather than a direct determinant of this syndrome.

  15. Genetic polymorphism at the CLOCK gene locus and major depression.

    Science.gov (United States)

    Desan, P H; Oren, D A; Malison, R; Price, L H; Rosenbaum, J; Smoller, J; Charney, D S; Gelernter, J

    2000-06-12

    Genetic analysis in both mouse and Drosophila has indicated that the product of the CLOCK gene is an essential component of a circadian rhythm timing system. A single nucleotide polymorphism (SNP), T3111C, in the 3' flanking region of the human CLOCK gene has been identified. Homozygotes or heterozygotes for the 3111C allele have been reported to have higher mean scores on a measure of evening preference for activity (vs. morning preference) than subjects homozygous for the 3111T allele. Since major depression is hypothesized to be closely linked to circadian rhythms, we explored whether this polymorphism might be related to susceptibility to major depression. We also ascertained allele frequency in an African-American control population, to begin to evaluate population variation at this locus. CLOCK T3111C allele frequencies were determined in 280 European American (EA) subjects, 143 with a history of major depression and 137 screened controls, and in 58 African American (AA) screened control subjects, using a polymerase chain reaction (PCR) - restriction fragment length polymorphism (RFLP) method. There was no significant difference between EA depressed and control subjects in allele frequency. There was a significant difference in allele frequency between EA and AA subjects, demonstrating a potential for population stratification. In none of these groups were significant deviations from Hardy-Weinberg equilibrium found. The present data do not support an association between CLOCK gene alleles at the T3111C locus and major depression.

  16. The Locus analytical framework for indoor localization and tracking applications

    Science.gov (United States)

    Segou, Olga E.; Thomopoulos, Stelios C. A.

    2015-05-01

    Obtaining location information can be of paramount importance in the context of pervasive and context-aware computing applications. Many systems have been proposed to date, e.g. GPS that has been proven to offer satisfying results in outdoor areas. The increased effect of large and small scale fading in indoor environments, however, makes localization a challenge. This is particularly reflected in the multitude of different systems that have been proposed in the context of indoor localization (e.g. RADAR, Cricket etc). The performance of such systems is often validated on vastly different test beds and conditions, making performance comparisons difficult and often irrelevant. The Locus analytical framework incorporates algorithms from multiple disciplines such as channel modeling, non-uniform random number generation, computational geometry, localization, tracking and probabilistic modeling etc. in order to provide: (a) fast and accurate signal propagation simulation, (b) fast experimentation with localization and tracking algorithms and (c) an in-depth analysis methodology for estimating the performance limits of any Received Signal Strength localization system. Simulation results for the well-known Fingerprinting and Trilateration algorithms are herein presented and validated with experimental data collected in real conditions using IEEE 802.15.4 ZigBee modules. The analysis shows that the Locus framework accurately predicts the underlying distribution of the localization error and produces further estimates of the system's performance limitations (in a best-case/worst-case scenario basis).

  17. Self-regulated alternative splicing at the AHNAK locus.

    Science.gov (United States)

    de Morrée, Antoine; Droog, Marjolein; Grand Moursel, Laure; Bisschop, Ilona J M; Impagliazzo, Antonietta; Frants, Rune R; Klooster, Rinse; van der Maarel, Silvère M

    2012-01-01

    AHNAK is a 700-kDa protein involved in cytoarchitecture and calcium signaling. It is secondarily reduced in muscle of dysferlinopathy patients and accumulates in muscle of calpainopathy patients, both affected by a muscular dystrophy. AHNAK directly interacts with dysferlin. This interaction is lost on cleavage of AHNAK by the protease calpain 3, explaining the molecular observations in patients. Currently, little is known of AHNAK regulation. We describe the self-regulation of multiple mRNA transcripts emanating from the AHNAK locus in muscle cells. We show that the AHNAK gene consists of a 17-kb exon flanked by multiple small exons. This genetic structure is shared by AHNAK2 and Periaxin, which share a common ancestor. Two major AHNAK transcripts are differentially expressed during muscle differentiation that encode for a small (17-kDa) and a large (700-kDa) protein isoform. These proteins interact in the cytoplasm, but the small AHNAK is also present in the nucleus. During muscle differentiation the small AHNAK is strongly increased, thereby establishing a positive feedback loop to regulate mRNA splicing of its own locus. A small 17-kDa isoform of Periaxin similarly traffics between the cytoplasm and the nucleus to regulate mRNA splicing. Thus, AHNAK constitutes a novel mechanism in post-transcriptional control of gene expression.

  18. Allelism of Genes in the Ml-a locus

    DEFF Research Database (Denmark)

    Giese, Nanna Henriette; Jensen, Hans Peter; Jørgensen, Jørgen Helms

    1980-01-01

    Seven barley lines or varieties, each with a different gene at the Ml-a locus for resistance to Erysiphe graminis were intercrossed. Progeny testing of the F2s using two different fungal isolates per cross provided evidence that there are two or more loci in the Ml-a region. Apparent recombinants...... were also screened for recombination between the Hor1 and Hor2 loci which are situated either side of the Ml-a locus. The cross between Ricardo and Iso42R (Rupee) yielded one possible recombinant, with Ml-a3 and Ml-a(Rul) in the coupling phase; other recombinants had wild-type genes in the coupling...... phase. Iso20R, derived from Hordeum spontaneum 'H204', carrying Ml-a6, had an additional gene, in close coupling with Ml-a6, tentatively named Ml-aSp2 or Reglv, causing an intermediate infection type with isolate EmA30. It is suggested that Ml-a(Ar) in Emir and Ml-a(Rul), shown to differ from other Ml-a...

  19. Variation in retinal degeneration phenotype inherited at the prcd locus.

    Science.gov (United States)

    Aguirre, G D; Acland, G M

    1988-05-01

    Progressive rod-cone degeneration (prcd) is a recessively inherited visual cell disease. Neither the genetic abnormality nor the corresponding biochemical defect have yet been identified. Unique abnormalities of visual cell structure, function and renewal, however, characterize the disease phenotype and act as a marker for the prcd gene. The disease was first described in miniature poodle dogs (MP) but broadly similar retinal degenerations have been recognized, clinically, in other breeds. Crossbreeding experiments with prcd-affected MP and retinal degenerate English (ECS) and American (ACS) cocker spaniels now demonstrate that all the progeny are affected with a retinal degeneration indistinguishable from prcd in the MP. This indicates that the gene mutation in each breed is at the same (prcd) locus. In purebred prcd-affected ECS (prcd-ECS), however, the disease phenotype consistently differs from that in prcd-MP in its rate of progression and in the topographical distribution of disease within the retina. Ultrastructural variation in disease expression are also recognizable between the two phenotypes. These differences in disease phenotype may be ascribable to different genetic backgrounds in the two breeds, reflecting the effect of modifying genes, or may indicate separate, allelic, mutations at the same locus.

  20. LOCUS: immunizing medical students against the loss of professional values.

    Science.gov (United States)

    Carufel-Wert, Donald A; Younkin, Sharon; Foertsch, Julie; Eisenberg, Todd; Haq, Cynthia L; Crouse, Byron J; Frey Iii, John J

    2007-05-01

    The Leadership Opportunities with Communities, the Underserved, and Special populations (LOCUS) program at the University of Wisconsin School of Medicine and Public Health is a longitudinal, extracurricular experience for medical students who wish to develop leadership skills and expand their involvement in community health activities during medical school. The program consists of a core curriculum delivered through retreats, workshops, and seminars; a mentor relationship with a physician who is engaged in community health services; and a community service project. On-line surveys and interviews with current and past participants as well as direct observations were used to evaluate the effects of the program on participants. Participants indicated that the program was worthwhile, relevant, and effective in building a community of like-minded peers and physician role models. Participants also reported that the program sustained their interest in and commitment to community service and allowed them to cultivate new skills during medical school. The curriculum and structure of the LOCUS program offers a successful method for helping medical students learn important leadership skills and maintain an altruistic commitment to service.

  1. Regulatory facility guide for Ohio

    Energy Technology Data Exchange (ETDEWEB)

    Anderson, S.S.; Bock, R.E.; Francis, M.W.; Gove, R.M.; Johnson, P.E.; Kovac, F.M.; Mynatt, J.O. [Oak Ridge National Lab., TN (United States); Rymer, A.C. [Transportation Consulting Services, Knoxville, TN (United States)

    1994-02-28

    The Regulatory Facility Guide (RFG) has been developed for the DOE and contractor facilities located in the state of Ohio. It provides detailed compilations of international, federal, and state transportation-related regulations applicable to shipments originating at destined to Ohio facilities. This RFG was developed as an additional resource tool for use both by traffic managers who must ensure that transportation operations are in full compliance with all applicable regulatory requirements and by oversight personnel who must verify compliance activities.

  2. Rhadinoviral interferon regulatory factor homologues.

    Science.gov (United States)

    Koch, Sandra; Schulz, Thomas F

    2017-07-26

    Kaposi's sarcoma-associated herpesvirus (KSHV), or human herpesvirus 8 (HHV8) is a gammaherpesvirus and the etiological agent of Kaposi's sarcoma, primary effusion lymphoma and multicentric Castleman disease. The KSHV genome contains genes for a unique group of proteins with homology to cellular interferon regulatory factors, termed viral interferon regulatory factors (vIRFs). This review will give an overview over the oncogenic, antiapoptotic and immunomodulatory characteristics of KSHV and related vIRFs.

  3. Are there gender differences in locus of control specific to alcohol dependence?

    Science.gov (United States)

    McPherson, Andrew; Martin, Colin R

    2017-01-01

    To investigate gender differences in locus of control in an alcohol-dependent population. Locus of control helps to explain behaviour in terms of internal (the individual is responsible) or external (outside forces, such as significant other people or chance, are responsible) elements. Past research on gender differences in locus of control in relation to alcohol dependence has shown mixed results. There is a need then to examine gender and locus of control in relation to alcohol dependence to ascertain the veracity of any locus of control differences as a function of gender. The Multidimensional Health Locus of Control form-C was administered to clients from alcohol dependence treatment centres in the West of Scotland. Independent t-tests were carried out to assess gender differences in alcohol dependence severity and internal/external aspects of locus of control. One hundred and eighty-eight (53% females) participants were recruited from a variety of alcohol dependence treatment centres. The majority of participants (72%) came from Alcoholics Anonymous groups. Women revealed a greater internal locus of control compared with men. Women also had a greater 'significant others' locus of control score than men. Men were more reliant on 'chance' and 'doctors' than women. All these trends were not, however, statistically significant. Gender differences in relation to locus of control and alcohol dependence from past studies are ambiguous. This study also found no clear statistically significant differences in locus of control orientation as a function of gender. This article helps nurses to contextualise health behaviours as a result of internal or external forces. It also helps nursing staff to better understand alcohol dependence treatment in relation to self-efficacy and control. Moreover, it highlights an important concept in health education theory. © 2016 John Wiley & Sons Ltd.

  4. Secondary evolution of a self-incompatibility locus in the Brassicaceae genus Leavenworthia.

    Directory of Open Access Journals (Sweden)

    Sier-Ching Chantha

    Full Text Available Self-incompatibility (SI is the flowering plant reproductive system in which self pollen tube growth is inhibited, thereby preventing self-fertilization. SI has evolved independently in several different flowering plant lineages. In all Brassicaceae species in which the molecular basis of SI has been investigated in detail, the product of the S-locus receptor kinase (SRK gene functions as receptor in the initial step of the self pollen-rejection pathway, while that of the S-locus cysteine-rich (SCR gene functions as ligand. Here we examine the hypothesis that the S locus in the Brassicaceae genus Leavenworthia is paralogous with the S locus previously characterized in other members of the family. We also test the hypothesis that self-compatibility in this group is based on disruption of the pollen ligand-producing gene. Sequence analysis of the S-locus genes in Leavenworthia, phylogeny of S alleles, gene expression patterns, and comparative genomics analyses provide support for both hypotheses. Of special interest are two genes located in a non-S locus genomic region of Arabidopsis lyrata that exhibit domain structures, sequences, and phylogenetic histories similar to those of the S-locus genes in Leavenworthia, and that also share synteny with these genes. These A. lyrata genes resemble those comprising the A. lyrata S locus, but they do not function in self-recognition. Moreover, they appear to belong to a lineage that diverged from the ancestral Brassicaceae S-locus genes before allelic diversification at the S locus. We hypothesize that there has been neo-functionalization of these S-locus-like genes in the Leavenworthia lineage, resulting in evolution of a separate ligand-receptor system of SI. Our results also provide support for theoretical models that predict that the least constrained pathway to the evolution of self-compatibility is one involving loss of pollen gene function.

  5. Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited

    DEFF Research Database (Denmark)

    Deelen, Joris; Beekman, Marian; Uh, Hae-Won

    2011-01-01

    (LLS) and 1670 younger population controls. The strongest candidate SNPs from this GWAS have been analyzed in a meta-analysis of nonagenarian cases from the Rotterdam Study, Leiden 85-plus study and Danish 1905 cohort. Only one of the 62 prioritized SNPs from the GWAS analysis (P ... genome-wide significance with survival into old age in the meta-analysis of 4149 nonagenarian cases and 7582 younger controls (OR = 0.71 (95% CI 0.65-0.77), P = 3.39 x 10(-17) ). This SNP, rs2075650, is located in TOMM40 at chromosome 19q13.32 close to the apolipoprotein E (APOE) gene. Although...... of the nonagenarian cases from the LLS and their partners. In addition, we observed a novel association between this locus and serum levels of IGF-1 in females (P = 0.005). In conclusion, the major locus determining familial longevity up to high age as detected by GWAS was marked by rs2075650, which tags...

  6. Targeted resequencing and analysis of the Diamond-Blackfan anemia disease locus RPS19.

    Directory of Open Access Journals (Sweden)

    Alvaro Martinez Barrio

    2009-07-01

    Full Text Available The Ribosomal protein S19 gene locus (RPS19 has been linked to two kinds of red cell aplasia, Diamond-Blackfan Anemia (DBA and Transient Erythroblastopenia in Childhood (TEC. Mutations in RPS19 coding sequences have been found in 25% of DBA patients, but not in TEC patients. It has been suggested that non-coding RPS19 sequence variants contribute to the considerable clinical variability in red cell aplasia. We therefore aimed at identifying non-coding variations associated with DBA or TEC phenotypes.We targeted a region of 19'980 bp encompassing the RPS19 gene in a cohort of 89 DBA and TEC patients for resequencing. We provide here a catalog of the considerable, previously unrecognized degree of variation in this region. We identified 73 variations (65 SNPs, 8 indels that all are located outside of the RPS19 open reading frame, and of which 67.1% are classified as novel. We hypothesize that specific alleles in non-coding regions of RPS19 could alter the binding of regulatory proteins or transcription factors. Therefore, we carried out an extensive analysis to identify transcription factor binding sites (TFBS. A series of putative interaction sites coincide with detected variants. Sixteen of the corresponding transcription factors are of particular interest, as they are housekeeping genes or show a direct link to hematopoiesis, tumorigenesis or leukemia (e.g. GATA-1/2, PU.1, MZF-1.Specific alleles at predicted TFBSs may alter the expression of RPS19, modify an important interaction between transcription factors with overlapping TFBS or remove an important stimulus for hematopoiesis. We suggest that the detected interactions are of importance for hematopoiesis and could provide new insights into individual response to treatment.

  7. Assessment of ADHD Documentation from Candidates Requesting Americans with Disabilities Act (ADA) Accommodations for the National Board of Osteopathic Medical Examiners COMLEX Exam

    Science.gov (United States)

    Joy, Javed A.; Julius, Rose J.; Akter, Rashida; Baron, David A.

    2010-01-01

    Purpose: Every year increasing numbers of candidates request special accommodations for high-stakes medical licensing examinations, due to ADHD, on the basis of the Americans with Disabilities Act (ADA). This poses significant challenges for both the applicant and the medical boards and has significant financial, legal, and ethical implications.…

  8. Atividades avançadas de vida diária e incidência de declínio cognitivo em idosos: Estudo SABE

    National Research Council Canada - National Science Library

    Eliane Golfieri Dias; Fabíola Bof de Andrade; Yeda Aparecida de Oliveira Duarte; Jair Lício Ferreira Santos; Maria Lúcia Lebrão

    2015-01-01

    O objetivo deste trabalho foi avaliar o impacto das atividades avançadas de vida diária (AAVD) na incidência de declínio cognitivo. A amostra foi composta por idosos participantes do estudo longitudinal...

  9. A Comparison of Diabetes Management in a Federal Prison with the National Standards of Care Published by the ADA in 1998

    Science.gov (United States)

    2000-05-01

    ADA standards. From the 14,539 diabetics identified within their organization 353 charts were randomly selected for review. Glycated hemoglobin (GHb...exam, HDL and LDL cholesterol measurement. 15. SUBJECT TERMS 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT SAR 18. NUMBER OF PAGES 58...6 Limitations

  10. Sickle cell anemia induces changes in peripheral lymphocytes E-NTPDase/E-ADA activities and cytokines secretion in patients under treatment.

    Science.gov (United States)

    Castilhos, Lívia G; Doleski, Pedro H; Bertoldo, Tatiana M D; Passos, Daniela F; Bertoncheli, Claudia de M; Rezer, João F P; Schlemmer, Josiane B; Leal, Daniela B R

    2015-07-01

    Sickle cell anemia (SCA) is characterized by hemoglobin polymerization that results in sickle-shaped red blood cells. The vascular obstruction by sickle erythrocytes is often inflammatory, and purinergic system ecto-enzymes play an important role in modulating the inflammatory and immune response. This study aimed to evaluate the E-NTPDase and E-ADA activities in lymphocytes of SCA treated patients, as well as verify the cytokine profile in this population. Fifteen SCA treated patients and 30 health subjects (control group) were selected. The peripheral lymphocytes were isolated and E-NTPDase and E-ADA activities were determined. Serum was separated from clot formation for the cytokines quantification. E-NTPDase (ATP and ADP as substrate) and E-ADA (adenosine as substrate) activities were increased in lymphocytes from SCA patients (P<0.001). The TNF-α and IL-6 serum cytokines showed decreased on SCA patients comparing to control (P<0.001). The regulation of extracellular nucleotides released in response to hypoxia and inflammation through E-NTPDase and E-ADA enzymes represent an important control of purine-mediated in the SCA disease, avoiding elevated adenosine levels in the extracellular medium and consequent organ injuries in these patients. The pro-inflammatory cytokines decreased levels by use of hydroxyurea occur in attempt to reduce the pro-inflammatory response and prevent vaso-oclusive crisis. Copyright © 2015 Elsevier Masson SAS. All rights reserved.

  11. 76 FR 40200 - Semiannual Regulatory Flexibility Agenda

    Science.gov (United States)

    2011-07-07

    ... Semiannual Regulatory Flexibility Agenda AGENCY: Board of Governors of the Federal Reserve System. ACTION: Semiannual regulatory agenda. SUMMARY: The Board is issuing this agenda under the Regulatory Flexibility Act... rules the Board has selected for review under section 610(c) of the Regulatory Flexibility Act, and...

  12. The fester locus in Botryllus schlosseri experiences selection

    Directory of Open Access Journals (Sweden)

    Nydam Marie L

    2012-12-01

    Full Text Available Abstract Background Allorecognition, the ability of an organism to distinguish self from non-self, occurs throughout the entire tree of life. Despite the prevalence and importance of allorecognition systems, the genetic basis of allorecognition has rarely been characterized outside the well-known MHC (Major Histocompatibility Complex in vertebrates and SI (Self-Incompatibility in plants. Where loci have been identified, their evolutionary history is an open question. We have previously identified the genes involved in self/non-self recognition in the colonial ascidian Botryllus schlosseri, and we can now begin to investigate their evolution. In B. schlosseri, colonies sharing 1 or more alleles of a gene called FuHC (Fusion Histocompatibility will fuse. Protein products of a locus called fester, located ~300 kb from FuHC, have been shown to play multiple roles in the histocompatibility reaction, as activating and/or inhibitory receptors. We test whether the proteins encoded by this locus are evolving neutrally or are experiencing balancing, directional, or purifying selection. Results Nearly all of the variation in the fester locus resides within populations. The 13 housekeeping genes (12 nuclear genes and mitochondrial cytochrome oxidase I have substantially more structure among populations within groups and among groups than fester. All polymorphism statistics (Tajima's D, Fu and Li's D* and F* are significantly negative for the East Coast A-type alleles, and Fu and Li's F* statistic is significantly negative for the West Coast A-type alleles. These results are likely due to selection rather than demography, given that 10 of the housekeeping loci have no populations with significant values for any of the polymorphism statistics. The majority of codons in the fester proteins have ω values 95% posterior probability of ω values > 1. Conclusion Fester proteins are evolving non-neutrally. The polymorphism statistics are consistent with either

  13. Interferon regulatory factor-1 polymorphisms are associated with the control of Plasmodium falciparum infection

    Science.gov (United States)

    Mangano, Valentina D; Luoni, Gaia; Rockett, Kirk A; Sirima, Bienvenu S; Konaté, Amadou; Forton, Julian; Clark, Taane; Bancone, Germana; Akha, Elham Sadighi; Kwiatkowski, Dominic P; Modiano, David

    2010-01-01

    We describe the haplotypic structure of the Interferon Regulatory Factor-1 (IRF-1) locus in two West African ethnic groups, Fulani and Mossi, that differ in their susceptibility and immune response to Plasmodium falciparum malaria. Both populations showed significant associations between IRF-1 polymorphisms and carriage of P. falciparum infection, with different patterns of association that may reflect their different haplotypic architecture. Genetic variation at this locus does not therefore account for the Fulani-specific resistance to malaria while it could contribute to parasite clearance's ability in populations living in endemic areas. We then conducted a case-control study of three haplotype-tagging Single Nucleotide Polymorphisms (htSNPs) in 370 hospitalized malaria patients (160 severe and 210 uncomplicated) and 410 healthy population controls, all from the Mossi ethnic group. All 3 htSNPs showed correlation with blood infection levels in malaria patients, and the rs10065633 polymorphism was associated with severe disease (p=0.02). These findings provide the first evidence of the involvement in malaria susceptibility of a specific locus within the 5q31 region, previously shown to be linked with P. falciparum infection levels. PMID:18200030

  14. Flowering Locus C (FLC) Is a Potential Major Regulator of Glucosinolate Content across Developmental Stages of Aethionema arabicum (Brassicaceae).

    Science.gov (United States)

    Mohammadin, Setareh; Nguyen, Thu-Phuong; van Weij, Marco S; Reichelt, Michael; Schranz, Michael E

    2017-01-01

    The biochemical defense of plants can change during their life-cycle and impact herbivore feeding and plant fitness. The annual species Aethionema arabicum is part of the sister clade to all other Brassicaceae. Hence, it holds a phylogenetically important position for studying crucifer trait evolution. Glucosinolates (GS) are essentially Brassicales-specific metabolites involved in plant defense. Using two Ae. arabicum accessions (TUR and CYP) we identify substantial differences in glucosinolate profiles and quantities between lines, tissues and developmental stages. We find tissue specific side-chain modifications in aliphatic GS: methylthioalkyl in leaves, methylsulfinylalkyl in fruits, and methylsulfonylalkyl in seeds. We also find large differences in absolute glucosinolate content between the two accessions (up to 10-fold in fruits) that suggest a regulatory factor is involved that is not part of the quintessential glucosinolate biosynthetic pathway. Consistent with this hypothesis, we identified a single major multi-trait quantitative trait locus controlling total GS concentration across tissues in a recombinant inbred line population derived from TUR and CYP. With fine-mapping, we narrowed the interval to a 58 kb region containing 15 genes, but lacking any known GS biosynthetic genes. The interval contains homologs of both the sulfate transporter SULTR2;1 and FLOWERING LOCUS C. Both loci have diverse functions controlling plant physiological and developmental processes and thus are potential candidates regulating glucosinolate variation across the life-cycle of Aethionema. Future work will investigate changes in gene expression of the candidates genes, the effects of GS variation on insect herbivores and the trade-offs between defense and reproduction.

  15. The DYX2 locus and neurochemical signaling genes contribute to speech sound disorder and related neurocognitive domains.

    Science.gov (United States)

    Eicher, J D; Stein, C M; Deng, F; Ciesla, A A; Powers, N R; Boada, R; Smith, S D; Pennington, B F; Iyengar, S K; Lewis, B A; Gruen, J R

    2015-04-01

    A major milestone of child development is the acquisition and use of speech and language. Communication disorders, including speech sound disorder (SSD), can impair a child's academic, social and behavioral development. Speech sound disorder is a complex, polygenic trait with a substantial genetic component. However, specific genes that contribute to SSD remain largely unknown. To identify associated genes, we assessed the association of the DYX2 dyslexia risk locus and markers in neurochemical signaling genes (e.g., nicotinic and dopaminergic) with SSD and related endophenotypes. We first performed separate primary associations in two independent samples - Cleveland SSD (210 affected and 257 unaffected individuals in 127 families) and Denver SSD (113 affected individuals and 106 unaffected individuals in 85 families) - and then combined results by meta-analysis. DYX2 markers, specifically those in the 3' untranslated region of DCDC2 (P = 1.43 × 10(-4) ), showed the strongest associations with phonological awareness. We also observed suggestive associations of dopaminergic-related genes ANKK1 (P = 1.02 × 10(-2) ) and DRD2 (P = 9.22 × 10(-3) ) and nicotinic-related genes CHRNA3 (P = 2.51 × 10(-3) ) and BDNF (P = 8.14 × 10(-3) ) with case-control status and articulation. Our results further implicate variation in putative regulatory regions in the DYX2 locus, particularly in DCDC2, influencing language and cognitive traits. The results also support previous studies implicating variation in dopaminergic and nicotinic neural signaling influencing human communication and cognitive development. Our findings expand the literature showing genetic factors (e.g., DYX2) contributing to multiple related, yet distinct neurocognitive domains (e.g., dyslexia, language impairment, and SSD). How these factors interactively yield different neurocognitive and language-related outcomes remains to be elucidated. © 2015 The Authors. Genes, Brain and Behavior published by

  16. Identification of regulatory modules in genome scale transcription regulatory networks.

    Science.gov (United States)

    Song, Qi; Grene, Ruth; Heath, Lenwood S; Li, Song

    2017-12-15

    In gene regulatory networks, transcription factors often function as co-regulators to synergistically induce or inhibit expression of their target genes. However, most existing module-finding algorithms can only identify densely connected genes but not co-regulators in regulatory networks. We have developed a new computational method, CoReg, to identify transcription co-regulators in large-scale regulatory networks. CoReg calculates gene similarities based on number of common neighbors of any two genes. Using simulated and real networks, we compared the performance of different similarity indices and existing module-finding algorithms and we found CoReg outperforms other published methods in identifying co-regulatory genes. We applied CoReg to a large-scale network of Arabidopsis with more than 2.8 million edges and we analyzed more than 2,300 published gene expression profiles to charaterize co-expression patterns of gene moduled identified by CoReg. We identified three types of modules in the Arabidopsis network: regulator modules, target modules and intermediate modules. Regulator modules include genes with more than 90% edges as out-going edges; Target modules include genes with more than 90% edges as incoming edges. Other modules are classified as intermediate modules. We found that genes in target modules tend to be highly co-expressed under abiotic stress conditions, suggesting this network struture is robust against perturbation. Our analysis shows that the CoReg is an accurate method in identifying co-regulatory genes in large-scale networks. We provide CoReg as an R package, which can be applied in finding co-regulators in any organisms with genome-scale regulatory network data.

  17. Functional Analysis of the Coronary Heart Disease Risk Locus on Chromosome 21q22

    DEFF Research Database (Denmark)

    Beaney, Katherine E.; Smith, Andrew J. P.; Folkersen, Lasse Westergaard

    2017-01-01

    Background. The coronary heart disease (CHD) risk locus on 21q22 (lead SNP rs9982601) lies within a "gene desert." The aim of this study was to assess if this locus is associated with CHD risk factors and to identify the functional variant(s) and gene(s) involved. Methods. A phenome scan...

  18. PHIP - a novel candidate breast cancer susceptibility locus on 6q14.1

    NARCIS (Netherlands)

    Jiao, X. (Xiang); Aravidis, C. (Christos); Marikkannu, R. (Rajeshwari); Rantala, J. (Johanna); Picelli, S. (Simone); Adamovic, T. (Tatjana); Liu, T. (Tao); Maguire, P. (Paula); B. Kremeyer (Barbara); Luo, L. (Liping); von Holst, S. (Susanna); Kontham, V. (Vinaykumar); Thutkawkorapin, J. (Jessada); Margolin, S. (Sara); Du, Q. (Quan); Lundin, J. (Johanna); Michailidou, K. (Kyriaki); Bolla, M.K. (Manjeet K.); Wang, Q. (Qin); Dennis, J. (Joe); Lush, M. (Michael); C.B. Ambrosone (Christine); I.L. Andrulis (Irene); H. Anton-Culver (Hoda); Antonenkova, N.N. (Natalia N.); Arndt, V. (Volker); M.W. Beckmann (Matthias); C. Blomqvist (Carl); W.J. Blot (William); Boeckx, B. (Bram); S.E. Bojesen (Stig); B. Bonnani (Bernardo); J.S. Brand (Judith S.); H. Brauch (Hiltrud); H. Brenner (Hermann); A. Broeks (Annegien); T. Brüning (Thomas); B. Burwinkel (Barbara); Cai, Q. (Qiuyin); J. Chang-Claude (Jenny); NBCS Collaborators, (); Couch, F.J. (Fergus J.); A. Cox (Angela); S.S. Cross (Simon); S.L. Deming-Halverson (Sandra); P. Devilee (Peter); I. dos Santos Silva (Isabel); Dörk, T. (Thilo); M. Eriksson (Mats); P.A. Fasching (Peter); J.D. Figueroa (Jonine); D. Flesch-Janys (Dieter); H. Flyger (Henrik); M. Gabrielson (Marike); M. García-Closas (Montserrat); Giles, G.G. (Graham G.); A. González-Neira (Anna); P. Guénel (Pascal); Q. Guo (Qi); Gündert, M. (Melanie); C.A. Haiman (Christopher); Hallberg, E. (Emily); U. Hamann (Ute); P. harrington (Patricia); M.J. Hooning (Maartje); J.L. Hopper (John); Huang, G. (Guanmengqian); A. Jakubowska (Anna); M. Jones (Michael); M. Kerin (Michael); V-M. Kosma (Veli-Matti); Kristensen, V.N. (Vessela N.); Lambrechts, D. (Diether); L. Le Marchand (Loic); J. Lubinski (Jan); A. Mannermaa (Arto); J.W.M. Martens (John); A. Meindl (Alfons); R.L. Milne (Roger); A.-M. Mulligan (Anna-Marie); S.L. Neuhausen (Susan); H. Nevanlinna (Heli); J. Peto (Julian); K. Pykäs (Katri); P. Radice (Paolo); V. Rhenius (Valerie); E.J. Sawyer (Elinor); M.K. Schmidt (Marjanka); R.K. Schmutzler (Rita); C.M. Seynaeve (Caroline); Shah, M. (Mitul); J. Simard (Jacques); Southey, M.C. (Melissa C.); A.J. Swerdlow (Anthony ); T. Truong (Thérèse); Wendt, C. (Camilla); R. Winqvist (Robert); W. Zheng (Wei); kConFab/AOCS Investigators, (); J. Benítez (Javier); A.M. Dunning (Alison); P.D.P. Pharoah (Paul); D.F. Easton (Douglas); K. Czene (Kamila); P. Hall (Per); A. Lindblom (Annika)

    2017-01-01

    textabstractMost non-BRCA1/2 breast cancer families have no identified genetic cause. We used linkage and haplotype analyses in familial and sporadic breast cancer cases to identify a susceptibility locus on chromosome 6q. Two independent genome-wide linkage analysis studies suggested a 3 Mb locus

  19. PHIP - a novel candidate breast cancer susceptibility locus on 6q14.1

    DEFF Research Database (Denmark)

    Jiao, Xiang; Aravidis, Christos; Marikkannu, Rajeshwari

    2017-01-01

    Most non-BRCA1/2 breast cancer families have no identified genetic cause. We used linkage and haplotype analyses in familial and sporadic breast cancer cases to identify a susceptibility locus on chromosome 6q. Two independent genome-wide linkage analysis studies suggested a 3 Mb locus on chromos...

  20. Relationship Between Coping Strategies and Locus of Control With the Anxiety of Death in Old People

    Directory of Open Access Journals (Sweden)

    Hadi Hashemi Razini

    2017-09-01

    Conclusion Death anxiety is one of the key factors in the mental health of older adults. With regards to our findings, coping strategies and locus of control have an important role in death anxiety in older adults. Therefore, by designing psychological interventions based on coping strategies and changing locus of control from external to internal, death anxiety among the older adults can be improved.